TY - JOUR T1 - Children Are Likely to Suffer Most from Our Fossil Fuel Addiction AN - 743115062; 201004-31-0307852 (CE); 12110184 (EN) AB - BACKGROUND: The periods of fetal and child development arguably represent the stages of greatest vulnerability to the dual impacts of fossil fuel combustion: the multiple toxic effects of emitted pollutants (polycyclic aromatic hydrocarbons, particles, sulfur oxides, nitrogen oxides, metals) and the broad health impacts of global climate change attributable in large part to carbon dioxide released by fossil fuel burning. OBJECTIVES: In this commentary I highlight current scientific evidence indicating that the fetus and young child are at heightened risk of developmental impairment, asthma, and cancer from fossil fuel pollutants and from the predicted effects of climate disruption such as heat waves, flooding, infectious disease, malnutrition, and trauma. Increased risk during early development derives from the inherently greater biologic vulnerability of the developing fetus and child and from their long future lifetime, during which early insults can potentially manifest as adult as well as childhood disease. I cite recent reports concluding that reducing dependence on fossil fuel and promoting clean and sustainable energy is economically feasible. DISCUSSION: Although much has been written separately about the toxicity of fossil fuel burning emissions and the effects of climate change on health, these two faces of the problem have not been viewed together with a focus on the developing fetus and child. Adolescence and old age are also periods of vulnerability, but the potential for both immediate and long-term adverse effects is greatest when exposure occurs prenatally or in the early years. CONCLUSIONS: Consideration of the full spectrum of health risks to children from fossil fuel combustion underscores the urgent need for environmental and energy policies to reduce fossil fuel dependence and maximize the health benefits to this susceptible population. We do not have to leave our children a double legacy of ill health and ecologic disaster. JF - Environmental Health Perspectives AU - Perera, Frederica P PY - 2008 SP - 987 EP - 990 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Fossil fuels KW - Health KW - Combustion KW - Risk KW - Children KW - Climate change KW - Pollutants KW - Economics KW - Disasters KW - Toxicity KW - Asthma KW - Ecology KW - Leaves KW - Energy policy KW - Adults KW - Impairment KW - Infectious diseases KW - Nitrogen oxides KW - Toxic KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Children+Are+Likely+to+Suffer+Most+from+Our+Fossil+Fuel+Addiction&rft.au=Perera%2C+Frederica+P&rft.aulast=Perera&rft.aufirst=Frederica&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. AN - 71641929; 18522492 AB - Hemoglobin (Hb) released into the circulation during hemolysis and chemically modified Hb proposed for use as oxygen therapeutics exert toxic effects that are partially attributable to heme's oxidant activity. Native extracellular Hb is scavenged by haptoglobin (Hp) after alphabeta-subunit dimerization. In the absence of Hp, monocyte/macrophage cell-surface CD163 binds and clears Hb. We evaluated several chemically modified Hbs to establish the role of chemical cross-linking patterns and molecular sizes on binding and clearance by each pathway. We found that Hbs possessing beta-globin cross-linking, irrespective of polymerization, demonstrate increased Hp affinity compared with alpha-globin-stabilized Hbs. These data suggest that Hb alpha-subunit accessibility is critical for Hp binding in the absence of dimerization. beta-Globin chain cross-linked tetramers/polymers displayed strong polyvalent Hp binding with increased viscosity and formation of visible gel matrices. Modified Hb interaction with CD163 and cellular uptake demonstrated an inverse relation with molecular size, irrespective of alpha and beta cross-linking. These findings were confirmed by HO-1 induction and intracellular ferritin accumulation in CD163-expressing HEK293 cells. Based on these results, a rational and systematic approach to HBOC design may be used to optimize interaction with endogenous Hb clearance and detoxification pathways. JF - Antioxidants & redox signaling AU - Buehler, Paul W AU - Vallelian, Florence AU - Mikolajczyk, Malgorzata G AU - Schoedon, Gabriele AU - Schweizer, Thomas AU - Alayash, Abdu I AU - Schaer, Dominik J AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Rockville, Maryland, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1449 EP - 1462 VL - 10 IS - 8 KW - Antigens, CD KW - 0 KW - Antigens, Differentiation, Myelomonocytic KW - Antioxidants KW - CD163 antigen KW - Haptoglobins KW - Hemoglobins KW - Receptors, Cell Surface KW - Receptors, Scavenger KW - Globins KW - 9004-22-2 KW - Ferritins KW - 9007-73-2 KW - Index Medicus KW - Dimerization KW - Humans KW - Surface Plasmon Resonance KW - Receptors, Scavenger -- metabolism KW - Antigens, CD -- genetics KW - Antigens, Differentiation, Myelomonocytic -- genetics KW - Haptoglobins -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Models, Biological KW - Receptors, Cell Surface -- metabolism KW - Chromatography, Gel KW - Ferritins -- metabolism KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Antigens, CD -- metabolism KW - Antigens, Differentiation, Myelomonocytic -- metabolism KW - Receptors, Cell Surface -- genetics KW - Globins -- metabolism KW - Cell Line KW - Signal Transduction -- physiology KW - Antioxidants -- metabolism KW - Hemoglobins -- metabolism KW - Hemoglobins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71641929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Structural+stabilization+in+tetrameric+or+polymeric+hemoglobin+determines+its+interaction+with+endogenous+antioxidant+scavenger+pathways.&rft.au=Buehler%2C+Paul+W%3BVallelian%2C+Florence%3BMikolajczyk%2C+Malgorzata+G%3BSchoedon%2C+Gabriele%3BSchweizer%2C+Thomas%3BAlayash%2C+Abdu+I%3BSchaer%2C+Dominik+J&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/10.1089%2Fars.2008.2028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/ars.2008.2028 ER - TY - JOUR T1 - Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms. AN - 69491439; 18759874 AB - Zinc diethyldithiocarbamate (ZDEC) and its disulfide, tetraethylthiuram disulfide (TETD), are rubber accelerators and contact allergens that cross-react in some individuals. This study explored potential protein haptenation mechanisms of ZDEC and its oxidation products. ZDEC oxidation/reduction products and sites of protein binding were assessed using high-performance liquid chromatography and mass spectrometry. The murine local lymph node assay (LLNA) was employed to probe haptenation mechanisms of ZDEC by examining its allergenicity along with its oxidation products and through elimination of oxidation and chelation mechanisms by substituting cobalt for zinc [cobalt (II) dithiocarbamate, CoDEC]. Oxidation of ZDEC by hypochlorous acid (bleach, HOCl), iodine, or hydrogen peroxide resulted in production of TETD, tetraethylthiocarbamoyl disulfide, and tetraethyldicarbamoyl disulfide (TEDCD). Albumin thiols reduced TETD with subsequent mixed disulfide formation/haptenation. ZDEC directly chelated the copper ion on the active site of the superoxide dismutase, whereas CoDEC did not bind to Cu proteins or form mixed disulfides with free thiols. ZDEC, sodium diethyldithiocarbamate, TEDCD, and TETD were all positive in the LLNA except CoDEC, which was non-allergenic. The thiol is the critical functional group in ZDEC's allergenicity, and haptenation is predominantly through chelation of metalloproteins and formation of mixed disulfides. JF - Contact dermatitis AU - Chipinda, Itai AU - Hettick, Justin M AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. ichipinda@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 79 EP - 89 VL - 59 IS - 2 KW - Allergens KW - 0 KW - Haptens KW - Ditiocarb KW - 99Z2744345 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Oxidation-Reduction KW - Cross-Sectional Studies KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Chromatography, High Pressure Liquid KW - Ditiocarb -- chemistry KW - Disulfiram -- chemistry KW - Allergens -- chemistry KW - Haptens -- chemistry KW - Dermatitis, Allergic Contact -- etiology KW - Dermatitis, Allergic Contact -- pathology KW - Ditiocarb -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69491439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Zinc+diethyldithiocarbamate+allergenicity%3A+potential+haptenation+mechanisms.&rft.au=Chipinda%2C+Itai%3BHettick%2C+Justin+M%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2008-08-01&rft.volume=59&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=1600-0536&rft_id=info:doi/10.1111%2Fj.1600-0536.2008.01399.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-10 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0536.2008.01399.x ER - TY - JOUR T1 - Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. AN - 69433269; 18708391 AB - Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Bhatti, Parveen AU - Doody, Michele M AU - Alexander, Bruce H AU - Yuenger, Jeff AU - Simon, Steven L AU - Weinstock, Robert M AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Abend, Michael AU - Preston, Dale L AU - Pharoah, Paul AU - Struewing, Jeffery P AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2007 EP - 2011 VL - 17 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - United States KW - Genotype KW - Humans KW - Chi-Square Distribution KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Likelihood Functions KW - Male KW - Female KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- etiology KW - Occupational Exposure -- adverse effects KW - Neoplasms, Radiation-Induced -- mortality KW - Neoplasms, Radiation-Induced -- genetics KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69433269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Breast+cancer+risk+polymorphisms+and+interaction+with+ionizing+radiation+among+U.S.+radiologic+technologists.&rft.au=Bhatti%2C+Parveen%3BDoody%2C+Michele+M%3BAlexander%2C+Bruce+H%3BYuenger%2C+Jeff%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAbend%2C+Michael%3BPreston%2C+Dale+L%3BPharoah%2C+Paul%3BStruewing%2C+Jeffery+P%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-16 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Cytogenet Genome Res. 2006;113(1-4):188-93 [16575179] Radiat Res. 2007 Jun;167(6):727-34 [17523852] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):954-6 [17618282] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7 [17932347] Int J Cancer. 2008 Jan 1;122(1):177-82 [17764108] Endocr Relat Cancer. 2001 Sep;8(3):197-209 [11566611] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Oncogene. 2003 Sep 1;22(37):5848-54 [12947391] Mol Carcinog. 2004 Sep;41(1):1-16 [15352122] J Chronic Dis. 1987;40 Suppl 2:45S-57S [3312274] JAMA. 1991 Mar 13;265(10):1290-4 [2053936] Breast Cancer Res. 2005;7(1):21-32 [15642178] Biochem Biophys Res Commun. 2006 Feb 3;340(1):83-9 [16359639] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0300 ER - TY - JOUR T1 - Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. AN - 69431595; 18566013 AB - This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1 inactive alleles compared with unexposed subjects with two inactive alleles (P-interaction: 0.04). Risk was highest among exposed subjects with both GSTM1 and GSTT1 active genotypes (OR: 6.47; 95% CI: 1.82-23.00; P-interaction: 0.02) compared with unexposed subjects with at least one GSTM1 or T1 inactive genotype. In the largest RCC case-control study with genotype information conducted to date, we observed that risk associated with pesticide exposure was exclusive to individuals with active GSTM1/T1 genotypes. These findings further support the hypothesis that glutathione S-transferase polymorphisms can modify RCC risk associated with occupational pesticide exposure. JF - Carcinogenesis AU - Karami, S AU - Boffetta, P AU - Rothman, N AU - Hung, R J AU - Stewart, T AU - Zaridze, D AU - Navritalova, M AU - Mates, D AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Szeszenia-Dabrowska, N AU - Holcatova, I AU - Mukeria, A AU - Gromiec, J AU - Chanock, S J AU - Brennan, P AU - Chow, W-H AU - Moore, L E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. karamis@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1567 EP - 1571 VL - 29 IS - 8 KW - Pesticides KW - 0 KW - GSTT2 protein, human KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Aged KW - Europe -- epidemiology KW - Risk Assessment KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- enzymology KW - Carcinoma, Renal Cell -- classification KW - Polymorphism, Genetic KW - Kidney Neoplasms -- enzymology KW - Kidney Neoplasms -- chemically induced KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics KW - Carcinoma, Renal Cell -- genetics KW - Pesticides -- toxicity KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69431595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+cell+carcinoma%2C+occupational+pesticide+exposure+and+modification+by+glutathione+S-transferase+polymorphisms.&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BRothman%2C+N%3BHung%2C+R+J%3BStewart%2C+T%3BZaridze%2C+D%3BNavritalova%2C+M%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N%3BHolcatova%2C+I%3BMukeria%2C+A%3BGromiec%2C+J%3BChanock%2C+S+J%3BBrennan%2C+P%3BChow%2C+W-H%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):449-54 [10794492] Am J Epidemiol. 2008 Apr 1;167(7):759-74 [18270371] Pharmacogenetics. 2001 Aug;11(6):521-35 [11505222] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Occup Med (Lond). 2002 May;52(3):157-64 [12063361] Med Lav. 2002 Jul-Aug;93(4):303-9 [12212398] Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):885-9 [12223433] Epidemiology. 2003 Sep;14(5):585-92 [14501274] Occup Environ Med. 2003 Oct;60(10):789-93 [14504370] Chem Biol Interact. 1986 Oct 15;60(1):31-45 [3536138] Toxicol Appl Pharmacol. 1991 Jan;107(1):54-62 [1987660] Scand J Work Environ Health. 1994 Jun;20(3):160-5 [7973487] Int J Cancer. 1995 May 29;61(5):601-5 [7768630] Int J Epidemiol. 1995 Feb;24(1):51-7 [7797356] Arch Toxicol. 1997;71(9):596-9 [9285043] Am J Epidemiol. 1998 Sep 1;148(5):424-30 [9737554] Cancer Res. 1999 Jun 15;59(12):2903-8 [10383153] Int J Cancer. 2005 Mar 10;114(1):101-8 [15523697] Rev Environ Health. 2005 Apr-Jun;20(2):103-18 [16121833] Int J Cancer. 2006 May 15;118(10):2543-7 [16353144] Am J Epidemiol. 2006 Dec 1;164(11):1027-42 [17000715] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Chem Biol Interact. 2000 Dec 1;129(1-2):61-76 [11154735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn153 ER - TY - JOUR T1 - Silicosis mortality among young adults in the United States, 1968-2004. AN - 69316008; 18521821 AB - To describe silicosis deaths in young (aged 15-44) adults in the U.S. during 1968-2004. We analyzed the National Center for Health Statistics multiple cause-of-death records. Compared with silicosis decedents aged >or=45 years (n = 15,643), young decedents (n = 237) were more likely to have silicosis listed as the underlying cause of death (74.3% vs. 48.2%, P < 0.001), to be female (9.3% vs. 2.2%, P < 0.001) and black (37.1% vs. 11.7%, P < 0.001). Twenty-nine young silicosis decedents had industry and occupation information available. Occupations in construction and manufacturing industries were associated with significantly elevated proportionate mortality ratios for young silicosis deaths. Silicosis deaths occur among young adults. Because these deaths are likely to reflect more intense and recent exposures, the follow-back investigations into the work sites where these individuals were exposed to silica should be conducted. JF - American journal of industrial medicine AU - Mazurek, Jacek M AU - Attfield, Michael D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia WV26 505, USA. acq8@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 568 EP - 578 VL - 51 IS - 8 KW - Index Medicus KW - Humans KW - Death Certificates KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Male KW - Female KW - Age Distribution KW - Silicosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69316008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=A+Mechanism+for+the+Inhibition+of+Neural+Progenitor+Cell+Proliferation+by+Cocaine&rft.au=Lee%2C+Chun-Ting%3BChen%2C+Jia%3BHayashi%2C+Teruo%3BTsai%2C+Shang-Yi%3BSanchez%2C+Joseph+F%3BErrico%2C+Stacie+L%3BAmable%2C+Rose%3BSu%2C+Tsung-Ping%3BLowe%2C+Ross+H%3BHuestis%2C+Marilyn+A%3BShen%2C+James%3BBecker%2C+Kevin+G%3BGeller%2C+Herbert+M%3BFreed%2C+William+J%3BGraeber%2C+Manuel&rft.aulast=Lee&rft.aufirst=Chun-Ting&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=e117&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.0050117 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-20 N1 - Date created - 2008-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20597 ER - TY - JOUR T1 - A meta-analysis of studies investigating the effects of lead exposure on nerve conduction AN - 21336129; 11722340 AB - Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log sub(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0kg/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver. JF - Archives of Toxicology AU - Krieg, Edward F AU - Chrislip, David W AU - Brightwell, WStephen AD - Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH, 45226, USA, erk3@cdc.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 531 EP - 542 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 82 IS - 8 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Sensory neurons KW - Muscles KW - Arm KW - Lead KW - Blood levels KW - Models KW - Leg KW - Blood KW - Action potential KW - peroneal nerve KW - Reviews KW - Liver KW - Kidney KW - Nerve conduction KW - Peripheral nerves KW - N3 11028:Neuropharmacology & toxicology KW - H 14000:Toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21336129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=A+meta-analysis+of+studies+investigating+the+effects+of+lead+exposure+on+nerve+conduction&rft.au=Krieg%2C+Edward+F%3BChrislip%2C+David+W%3BBrightwell%2C+WStephen&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2008-08-01&rft.volume=82&rft.issue=8&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-008-0292-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sensory neurons; Muscles; Arm; Lead; Models; Leg; Blood; Action potential; peroneal nerve; Reviews; Kidney; Liver; Nerve conduction; Peripheral nerves; Blood levels DO - http://dx.doi.org/10.1007/s00204-008-0292-z ER - TY - JOUR T1 - Rapid detection of ricin in cosmetics and elimination of artifacts associated with wheat lectin AN - 20063429; 8418576 AB - Ricin can be detected in cosmetics at 0.005 ?g/mL in the analytical sample using lateral flow devices (LFDs). Wheat germ, an ingredient used in skin care products is also a potential source of wheat lectin. False positives were observed when wheat lectin was added to LFDs from two manufacturers, irrespective of whether the LFD was specific for ricin, Staphylococcus enterotoxin B (SEB), or botulinum toxin. In contrast, pea and peanut lectins did not cause false positives. Substitution of the buffer supplied with the LFDs with a buffer containing 2.5% non-fat milk powder eliminated the occurrence of false positives. This substitution increased the LOD to 0.01 ?g/mL ricin, which is an acceptable level for screening cosmetics for contamination by ricin. JF - Journal of Immunological Methods AU - Dayan-Kenigsberg, J AU - Bertocchi, A AU - Garber, EAE AD - Center for Food Safety and Applied Nutrition, HFS-716, 5100 Paint Branch Pkwy., College Park, MD, 20740, USA, Eric.Garber@fda.hhs.gov Y1 - 2008/07/31/ PY - 2008 DA - 2008 Jul 31 SP - 251 EP - 254 PB - Elsevier Science, P.O. Box 211 Langford Lane Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 336 IS - 2 SN - 0022-1759, 0022-1759 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Arachis hypogaea KW - Powder KW - Skin KW - Milk KW - Wheat germ KW - Staphylococcus KW - Ricin KW - Nuts KW - Lectins KW - Cosmetics KW - Food contamination KW - Triticum aestivum KW - Botulinum toxin KW - enterotoxin B KW - F 06900:Methods KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20063429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Rapid+detection+of+ricin+in+cosmetics+and+elimination+of+artifacts+associated+with+wheat+lectin&rft.au=Dayan-Kenigsberg%2C+J%3BBertocchi%2C+A%3BGarber%2C+EAE&rft.aulast=Dayan-Kenigsberg&rft.aufirst=J&rft.date=2008-07-31&rft.volume=336&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2008.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Powder; Milk; Skin; Wheat germ; Ricin; Nuts; Cosmetics; Lectins; Botulinum toxin; Food contamination; enterotoxin B; Triticum aestivum; Arachis hypogaea; Staphylococcus DO - http://dx.doi.org/10.1016/j.jim.2008.05.007 ER - TY - JOUR T1 - Mapping prefrontal circuits in vivo with manganese-enhanced magnetic resonance imaging in monkeys. AN - 69347078; 18650340 AB - Manganese-enhanced magnetic resonance imaging (MEMRI) provides a powerful tool to study multisynaptic circuits in vivo and thereby to link information about neural structure and function within individual subjects. Making the best use of MEMRI in monkeys requires minimizing manganese-associated neurotoxicity, maintaining sensitivity to manganese-dependent signal changes and mapping transport throughout the brain without a priori anatomical hypotheses. Here, we performed intracortical injections of isotonic MnCl(2), comparisons of preinjection and postinjection scans, and voxelwise statistical mapping. Isotonic MnCl(2) did not cause cell death at the injection site, damage to downstream targets of manganese transport, behavioral deficits, or changes in neuronal responsiveness. We detected and mapped manganese transport throughout cortical-subcortical circuits by using voxelwise statistical comparisons of at least 10 preinjection and two postinjection scans. We were able to differentiate between focal and diffuse projection fields and to distinguish between the topography of striatal projections from orbitofrontal and anterior cingulate cortex in a single animal. This MEMRI approach provides a basis for combining circuit-based anatomical analyses with simultaneous single-unit recordings and/or functional magnetic resonance imaging in individual monkeys. Such studies will enhance our interpretations of functional data and our understanding of how neuronal activity is transformed as it propagates through a circuit. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Simmons, Janine M AU - Saad, Ziad S AU - Lizak, Martin J AU - Ortiz, Michael AU - Koretsky, Alan P AU - Richmond, Barry J AD - Department of Health and Human Services, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA. Y1 - 2008/07/23/ PY - 2008 DA - 2008 Jul 23 SP - 7637 EP - 7647 VL - 28 IS - 30 KW - Manganese KW - 42Z2K6ZL8P KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Action Potentials -- physiology KW - Animals KW - Conditioning, Classical -- physiology KW - Neural Pathways -- physiology KW - Action Potentials -- drug effects KW - Haplorhini KW - Photic Stimulation -- methods KW - Neural Pathways -- blood supply KW - Oxygen -- blood KW - Neural Pathways -- anatomy & histology KW - Time Factors KW - Image Processing, Computer-Assisted KW - Female KW - Male KW - Magnetic Resonance Imaging KW - Manganese -- pharmacology KW - Brain Mapping KW - Prefrontal Cortex -- anatomy & histology KW - Prefrontal Cortex -- physiology KW - Prefrontal Cortex -- blood supply KW - Image Enhancement -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69347078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Practice-specific+risk+perceptions+and+self-reported+food+safety+practices&rft.au=Levy%2C+Alan+S%3BChoini%C3%A8re%2C+Conrad+J%3BFein%2C+Sara+B&rft.aulast=Levy&rft.aufirst=Alan&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01051.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-07-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurophysiol. 2000 Apr;83(4):1864-76 [10758098] J Cereb Blood Flow Metab. 2008 Apr;28(4):832-40 [17987047] J Neurosci Methods. 2000 Nov 15;103(1):63-71 [11074096] Magn Reson Med. 2001 Sep;46(3):424-9 [11550231] Neuroscience. 2002;112(2):467-74 [12044464] Neuron. 2002 May 30;34(5):685-700 [12062017] Magn Reson Med. 2003 Jul;50(1):33-9 [12815676] Neuroimage. 2003 Nov;20(3):1591-600 [14642470] Magn Reson Med. 2004 Jan;51(1):22-6 [14705041] Neuroimage. 2004 Mar;21(3):914-23 [15006658] Exp Brain Res. 1983;49(1):93-115 [6861938] J Neurosci. 1985 Mar;5(3):776-94 [2983048] Arch Toxicol. 1987;61(1):46-52 [3439874] Arch Toxicol. 1992;66(5):359-64 [1319135] Science. 1993 Feb 5;259(5096):819-21 [7679223] Exp Neurol. 1993 Mar;120(1):89-94 [8477830] J Neurochem. 1994 Jan;62(1):205-16 [7505311] Brain Res. 1994 Sep 19;657(1-2):124-32 [7820609] J Comp Neurol. 1994 Dec 15;350(3):337-56 [7533796] Magn Reson Med. 1995 May;33(5):636-47 [7596267] J Neurosci. 1995 Jul;15(7 Pt 1):4851-67 [7623116] J Neurosci. 1995 Sep;15(9):5999-6013 [7666184] Neurology. 1996 Feb;46(2):492-8 [8614520] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] NMR Biomed. 1997 Jun-Aug;10(4-5):171-8 [9430344] Magn Reson Med. 1998 Nov;40(5):740-8 [9797158] Neurotoxicology. 1999 Apr-Jun;20(2-3):227-38 [10385886] NMR Biomed. 2004 Dec;17(8):532-43 [15617052] NMR Biomed. 2004 Dec;17(8):554-68 [15617054] NMR Biomed. 2004 Dec;17(8):595-601 [15761948] Magn Reson Med. 2006 Mar;55(3):604-11 [16470592] Magn Reson Imaging. 2006 May;24(4):349-58 [16677940] J Neurosci. 2006 Aug 9;26(32):8368-76 [16899732] Cereb Cortex. 2008 Jan;18(1):93-103 [17434918] Neuroimage. 2008 Apr 1;40(2):458-72 [18222710] J Comp Neurol. 2000 Sep 25;425(3):447-70 [10972944] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.1488-08.2008 ER - TY - JOUR T1 - Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies. AN - 69315004; 18628451 AB - To describe the considerations leading to marketing approval of ixabepilone in combination with capecitabine and as monotherapy for the treatment of advanced breast cancer that is refractory to other chemotherapies. Data from one randomized multicenter trial comparing combination therapy with ixabepilone and capecitabine to capecitabine alone were analyzed for support of the combination therapy indication. For monotherapy, a single-arm trial of ixabepilone was analyzed. Supporting data came from an additional single-arm combination therapy study and two single-arm monotherapy studies. In patients with metastatic or locally advanced breast cancer who had disease progression on or following an anthracycline and a taxane, ixabepilone plus capecitabine showed an improvement in progression-free survival compared with capecitabine alone {median progression-free survival, 5.7 [95% confidence interval (95% CI), 4.8-6.7] versus 4.1 (95% CI, 3.1-4.3) months, stratified log-rank P < 0.0001; hazard ratio, 0.69 (95% CI, 0.58-0.83)}. As monotherapy for patients who had disease progression on or following an anthracycline, a taxane, and capecitabine, ixabepilone as monotherapy showed a 12% objective response rate by independent blinded review and 18% by investigator assessment. The major toxicities from ixabepilone therapy were peripheral neuropathy and myelosuppression, particularly neutropenia. On October 16, 2007, the Food and Drug Administration approved ixabepilone for injection in combination with capecitabine or as monotherapy for the treatment of patients with advanced breast cancer who have experienced disease progression on previous chemotherapies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Lechleider, Robert J AU - Kaminskas, Edvardas AU - Jiang, Xiaoping AU - Aziz, Robeena AU - Bullock, Julie AU - Kasliwal, Ravindra AU - Harapanhalli, Ravi AU - Pope, Sarah AU - Sridhara, Rajeshwari AU - Leighton, John AU - Booth, Brian AU - Dagher, Ramzi AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20903, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 4378 EP - 4384 VL - 14 IS - 14 SN - 1078-0432, 1078-0432 KW - Epothilones KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - ixabepilone KW - K27005NP0A KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Epothilones -- adverse effects KW - Aged KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Neoplasm Recurrence, Local -- drug therapy KW - Deoxycytidine -- adverse effects KW - Neoplasm Metastasis -- drug therapy KW - Fluorouracil -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Female KW - Epothilones -- administration & dosage KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Drug Resistance, Neoplasm KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69315004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Ixabepilone+in+combination+with+capecitabine+and+as+monotherapy+for+treatment+of+advanced+breast+cancer+refractory+to+previous+chemotherapies.&rft.au=Lechleider%2C+Robert+J%3BKaminskas%2C+Edvardas%3BJiang%2C+Xiaoping%3BAziz%2C+Robeena%3BBullock%2C+Julie%3BKasliwal%2C+Ravindra%3BHarapanhalli%2C+Ravi%3BPope%2C+Sarah%3BSridhara%2C+Rajeshwari%3BLeighton%2C+John%3BBooth%2C+Brian%3BDagher%2C+Ramzi%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Lechleider&rft.aufirst=Robert&rft.date=2008-07-15&rft.volume=14&rft.issue=14&rft.spage=4378&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-0015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-0015 ER - TY - JOUR T1 - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. AN - 69281505; 18505381 AB - Injection drug users (IDUs) who successfully clear hepatitis C virus (HCV) have a reduced risk of developing chronic reinfection, despite their continuing exposure to the virus. To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years). HCV-specific T cell responses were assessed in proliferation, enzyme-linked immunospot (ELISPOT), interferon (IFN)-gamma secretion, and cytotoxicity assays, whereas HCV-specific antibodies were assessed in enzyme immunoassays (EIAs), chemiluminescent assays, and in vitro neutralization assays. HCV-specific T cell proliferation and IFN-gamma production were more common in nonviremic EIA-positive IDUs (16 [94%] of 17 IDUs) than in viremic EIA-positive IDUs (9 [45%] of 20 IDUs) (P= .003). They were also noted in 16 (62%) of 26 nonviremic EIA-negative IDUs. In contrast, 19 (90%) of 21 viremic IDUs displayed neutralizing antibodies (nAbs), compared with 9 (56%) of 16 nonviremic EIA-positive IDUs (P= .04) and 0 of 24 nonviremic EIA-negative IDUs. Nonviremic IDUs with nAbs were older (P= .0115) than those without nAbs, but these groups did not differ in terms of either injection drug use duration or HCV-specific T cell responses. The reduced risk of HCV persistence in IDUs previously recovered from HCV infection correlated with T cell responses, and prolonged antigenic stimulation appears to be required to maintain humoral responses. JF - The Journal of infectious diseases AU - Mizukoshi, Eishiro AU - Eisenbach, Christoph AU - Edlin, Brian R AU - Newton, Kimberly P AU - Raghuraman, Sukanya AU - Weiler-Normann, Christina AU - Tobler, Leslie H AU - Busch, Michael P AU - Carrington, Mary AU - McKeating, Jane A AU - O'Brien, Thomas R AU - Rehermann, Barbara AD - Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 203 EP - 212 VL - 198 IS - 2 SN - 0022-1899, 0022-1899 KW - Cytokines KW - 0 KW - Viral Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Proteins -- genetics KW - Humans KW - Cytokines -- secretion KW - Leukocytes, Mononuclear -- immunology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Risk Assessment KW - Genotype KW - Lymphocyte Activation KW - Cross-Sectional Studies KW - Leukocytes, Mononuclear -- virology KW - Viremia -- epidemiology KW - Incidence KW - Interferon-gamma -- blood KW - United States -- epidemiology KW - T-Lymphocytes -- immunology KW - Hepacivirus -- pathogenicity KW - Hepatitis C -- transmission KW - Hepacivirus -- genetics KW - Substance Abuse, Intravenous -- immunology KW - Hepatitis C -- epidemiology KW - Hepatitis C -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69281505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Service+Review&rft.atitle=Funneling+Child+Welfare+Consumers+into+and+through+the+Mental+Health+System%3A+Assessment%2C+Referral%2C+and+Quality+Issues&rft.au=Fedoravicius%2C+Nicole%3BMcMillen%2C+J+Curtis%3BRowe%2C+Jill+E%3BKagotho%2C+Njeri%3BWare%2C+Norma+C&rft.aulast=Fedoravicius&rft.aufirst=Nicole&rft.date=2008-06-01&rft.volume=82&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Social+Service+Review&rft.issn=00377961&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Liver Dis. 2005 Feb;25(1):7-17 [15731994] J Clin Invest. 1998 Nov 1;102(9):1758-65 [9802890] J Clin Microbiol. 2005 May;43(5):2477-80 [15872288] Am J Trop Med Hyg. 2005 Jul;73(1):44-9 [16014830] Hepatology. 2006 Nov;44(5):1139-45 [17058216] Gastroenterology. 2007 Feb;132(2):667-78 [17258731] Gastroenterology. 2007 Feb;132(2):654-66 [17258733] Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6025-30 [17392433] Hepatology. 2007 Sep;46(3):666-71 [17657818] J Exp Med. 2000 May 1;191(9):1499-512 [10790425] Nat Med. 2000 May;6(5):578-82 [10802716] J Virol. 2001 Feb;75(3):1229-35 [11152496] Am J Public Health. 2001 Jan;91(1):46-7 [11189823] J Clin Invest. 2001 Feb;107(3):341-9 [11160158] Lancet. 2001 May 5;357(9266):1397-401 [11356437] Am J Public Health. 2002 Mar;92(3):385-7 [11867316] Lancet. 2002 Apr 27;359(9316):1478-83 [11988247] J Virol. 2002 Jun;76(12):6104-13 [12021343] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] J Infect Dis. 2003 Mar 15;187(6):974-81 [12660944] J Virol. 2003 Apr;77(8):4781-93 [12663785] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7271-6 [12761383] J Exp Med. 2003 Jun 16;197(12):1645-55 [12810686] Trends Immunol. 2003 Aug;24(8):456-64 [12909460] Science. 2003 Oct 24;302(5645):659-62 [14576438] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204 [14617769] J Immunol. 2004 Jan 1;172(1):483-92 [14688358] J Virol. 2004 Feb;78(3):1575-81 [14722311] J Clin Microbiol. 2004 Feb;42(2):610-7 [14766824] Hepatology. 2004 Jul;40(1):87-97 [15239090] Hepatology. 2004 Jul;40(1):98-107 [15239091] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10149-54 [15220475] Gastroenterology. 2004 Sep;127(3):924-36 [15362047] AIDS. 1988 Feb;2(1):55-60 [3128998] West J Med. 1992 Jan;156(1):30-5 [1310362] N Engl J Med. 1992 Dec 31;327(27):1899-905 [1280771] JAMA. 1994 Jan 12;271(2):115-20 [8264065] Medicine (Baltimore). 1995 Jul;74(4):212-20 [7623656] Lancet. 1995 Oct 14;346(8981):1006-7 [7475549] Am J Public Health. 1995 Nov;85(11):1531-7 [7485666] Am J Public Health. 1996 May;86(5):642-54 [8629714] NIDA Res Monogr. 1995;157:212-30 [8684438] J Infect Dis. 1997 Aug;176(2):518-22 [9237722] J Infect Dis. 1997 Oct;176(4):859-66 [9333142] Nature. 1998 Mar 5;392(6671):86-9 [9510252] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/589510 ER - TY - JOUR T1 - The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. AN - 69243708; 18430446 AB - Acrylamide (AA) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. The observation of cancer in endocrine-responsive tissues in Fischer 344 rats has prompted hypotheses of hormonal dysregulation, as opposed to DNA damage, as the mechanism for tumor induction by AA. The current investigation examines possible evidence for disruption of the hypothalamic-pituitary-thyroid axis from 14 days of repeated exposure of male Fischer 344 rats to doses of AA that range from one that is carcinogenic after lifetime exposure (2.5 mg/kg/d), an intermediate dose (10 mg/kg/d), and a high dose (50 mg/kg/d) that is neurotoxic for this exposure time. The endpoints selected include: serum levels of thyroid and pituitary hormones; target tissue expression of genes involved in hormone synthesis, release, and receptors; neurotransmitters in the CNS that affect hormone homeostasis; and histopathological evaluation of target tissues. These studies showed virtually no evidence for systematic alteration of the hypothalamic-pituitary-thyroid axis and do not support hormone dysregulation as a plausible mechanism for AA-induced thyroid cancer in the Fischer 344 rat. Specifically, there were no significant changes in: 1) mRNA levels in hypothalamus or pituitary for TRH, TSH, thyroid hormone receptor alpha and beta, as well 10 other hormones or releasing factors; 2) mRNA levels in thyroid for thyroglobulin, thyroid peroxidase, sodium iodide symporter, or type I deiodinases; 3) serum TSH or T3 levels (T4 was decreased at high dose only); 4) dopaminergic tone in the hypothalamus and pituitary or importantly 5) increased cell proliferation (Mki67 mRNA and Ki-67 protein levels were not increased) in thyroid or pituitary. These negative findings are consistent with a genotoxic mechanism of AA carcinogenicity based on metabolism to glycidamide and DNA adduct formation. Clarification of this mechanistic dichotomy may be useful in human cancer risk assessments for AA. JF - Toxicology and applied pharmacology AU - Bowyer, J F AU - Latendresse, J R AU - Delongchamp, R R AU - Muskhelishvili, L AU - Warbritton, A R AU - Thomas, M AU - Tareke, E AU - McDaniel, L P AU - Doerge, D R AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 208 EP - 215 VL - 230 IS - 2 SN - 0041-008X, 0041-008X KW - Acrylamides KW - 0 KW - Biogenic Monoamines KW - DNA, Complementary KW - Hormones KW - Receptors, Neurotransmitter KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - DNA, Complementary -- genetics KW - Cell Count KW - Receptors, Neurotransmitter -- metabolism KW - Liver -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Biogenic Monoamines -- metabolism KW - RNA -- biosynthesis KW - Rats KW - Rats, Inbred F344 KW - Liver -- drug effects KW - RNA -- isolation & purification KW - Image Processing, Computer-Assisted KW - Immunohistochemistry KW - Cell Cycle -- drug effects KW - DNA, Complementary -- biosynthesis KW - Male KW - Hypothalamo-Hypophyseal System -- drug effects KW - Thyroid Gland -- drug effects KW - Thyroid Gland -- pathology KW - Brain Chemistry -- drug effects KW - Acrylamides -- toxicity KW - Hormones -- blood KW - Hypothalamo-Hypophyseal System -- metabolism KW - Hypothalamo-Hypophyseal System -- pathology KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69243708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=The+effects+of+subchronic+acrylamide+exposure+on+gene+expression%2C+neurochemistry%2C+hormones%2C+and+histopathology+in+the+hypothalamus-pituitary-thyroid+axis+of+male+Fischer+344+rats.&rft.au=Bowyer%2C+J+F%3BLatendresse%2C+J+R%3BDelongchamp%2C+R+R%3BMuskhelishvili%2C+L%3BWarbritton%2C+A+R%3BThomas%2C+M%3BTareke%2C+E%3BMcDaniel%2C+L+P%3BDoerge%2C+D+R&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2008-07-15&rft.volume=230&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2008.02.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-22 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Appl Pharmacol. 2008 Nov 1;232(3):498 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.02.028 ER - TY - JOUR T1 - The Membrane Form of Tumor Necrosis Factor Is Sufficient to Mediate Partial Innate Immunity to Francisella tularensis Live Vaccine Strain AN - 19810174; 8640992 AB - Here we characterize Francisella tularensis live vaccine strain (LVS) infection in total tumor necrosis factor (TNF) knockout (KO) mice and in transgenic mice expressing only the membrane form of TNF (memTNF). MemTNF mice, but not TNF KO mice, survived low-dose, sublethal LVS infections. Splenic nitric oxide production was impaired in infected memTNF mice and was absent in infected TNF KO mice. Spleen cell production of interferon- gamma , RANTES, and monocyte chemotactic protein-1 was elevated in TNF KO mice, compared with that in WT mice, by days 4-5 after infection, along with transiently increased numbers of CCR2 super(+) cells, whereas memTNF mice had an intermediate phenotype. By day 6 after infection, TNF KO mice, but not memTNF mice, exhibited massive apoptosis in spleens and livers, which shortly preceded their death. Thus, memTNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice. JF - Journal of Infectious Diseases AU - Cowley, S C AU - Goldberg, M F AU - Ho, JA AU - Elkins, K L AD - CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, siobhan.cowley@fda.hhs.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 284 EP - 292 VL - 198 IS - 2 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Apoptosis KW - Tumor necrosis factor KW - RANTES KW - Spleen KW - Francisella tularensis KW - Immunity KW - Transgenic mice KW - Infection KW - Liver KW - Nitric oxide KW - Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19810174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+Membrane+Form+of+Tumor+Necrosis+Factor+Is+Sufficient+to+Mediate+Partial+Innate+Immunity+to+Francisella+tularensis+Live+Vaccine+Strain&rft.au=Cowley%2C+S+C%3BGoldberg%2C+M+F%3BHo%2C+JA%3BElkins%2C+K+L&rft.aulast=Cowley&rft.aufirst=S&rft.date=2008-07-15&rft.volume=198&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F589620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Chemokines; Apoptosis; Monocyte chemoattractant protein 1; Tumor necrosis factor; Spleen; RANTES; Immunity; Infection; Transgenic mice; Liver; Nitric oxide; Vaccines; Francisella tularensis DO - http://dx.doi.org/10.1086/589620 ER - TY - CPAPER T1 - In Vivo Evidence that the Neurovirulence of Mumps Virus Clinical Isolate 88-1961 is a Multigenic Trait T2 - 27th Annual Meeting of the American Society for Virology AN - 41065640; 4913416 JF - 27th Annual Meeting of the American Society for Virology AU - Sauder, Christian AU - Zhang, Cheryl AU - Malik, Tahir AU - Duprex, Paul AU - Carbone, Kathryn AU - Rubin, Steven Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mumps KW - Clinical isolates KW - Neurovirulence KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=In+Vivo+Evidence+that+the+Neurovirulence+of+Mumps+Virus+Clinical+Isolate+88-1961+is+a+Multigenic+Trait&rft.au=Sauder%2C+Christian%3BZhang%2C+Cheryl%3BMalik%2C+Tahir%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improvement of Growth Characteristics of Influenza B Viruses by Specific Amino Acid Substitutions in Hemagglutinin T2 - 27th Annual Meeting of the American Society for Virology AN - 41065180; 4913746 JF - 27th Annual Meeting of the American Society for Virology AU - Lugovtsev, Vladimir Y AU - Vodeiko, Galina M AU - Levandowski, Roland A AU - Weir, Jerry P Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Amino acids KW - Influenza KW - Viruses KW - Influenza B KW - Hemagglutinins KW - Amino acid substitution KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Heme-oxygenase+1+Gene+Expression+is+a+Marker+for+Hexavalent+Chromium-Induced+Stress+and+Toxicity+in+Human+Dermal+Fibroblasts&rft.au=Joseph%2C+Pius%3BHe%2C+Quanren%3BUmbright%2C+Christina&rft.aulast=Joseph&rft.aufirst=Pius&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigation of the Contribution of the Surface and Matrix Proteins of Mumps Virus Strain Urabe AM9 to Neurovirulence T2 - 27th Annual Meeting of the American Society for Virology AN - 41061682; 4913587 JF - 27th Annual Meeting of the American Society for Virology AU - Link, Malen A AU - Sauder, Christian AU - Zhang, Cheryl AU - Duprex, Paul AU - Carbone, Kathryn M AU - Rubin, Steven Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mumps KW - Matrix protein KW - Neurovirulence KW - Strains KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41061682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Investigation+of+the+Contribution+of+the+Surface+and+Matrix+Proteins+of+Mumps+Virus+Strain+Urabe+AM9+to+Neurovirulence&rft.au=Link%2C+Malen+A%3BSauder%2C+Christian%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn+M%3BRubin%2C+Steven&rft.aulast=Link&rft.aufirst=Malen&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Protection Induced by a Live Attenuated Matrix Gene (M1) Mutant Virus Against Homologous and Heterologous Influenza Challenges in Mice T2 - 27th Annual Meeting of the American Society for Virology AN - 41060220; 4913596 JF - 27th Annual Meeting of the American Society for Virology AU - Xie, Hang AU - Wu, Zhengqi AU - Liu, Teresa AU - Ye, Zhiping Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mice KW - Mutants KW - Influenza UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41060220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Mechanism+of+Protection+Induced+by+a+Live+Attenuated+Matrix+Gene+%28M1%29+Mutant+Virus+Against+Homologous+and+Heterologous+Influenza+Challenges+in+Mice&rft.au=Xie%2C+Hang%3BWu%2C+Zhengqi%3BLiu%2C+Teresa%3BYe%2C+Zhiping&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of H5N1 Influenza Neuraminidase Stalk Chimeras on Virus Growth T2 - 27th Annual Meeting of the American Society for Virology AN - 41055542; 4913728 JF - 27th Annual Meeting of the American Society for Virology AU - Adamo, Joan E AU - Liu, Teresa AU - Schmeisser, Falko M AU - Ye, Zhiping Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Influenza KW - Chimeras KW - Exo-a-sialidase KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41055542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Analysis+of+H5N1+Influenza+Neuraminidase+Stalk+Chimeras+on+Virus+Growth&rft.au=Adamo%2C+Joan+E%3BLiu%2C+Teresa%3BSchmeisser%2C+Falko+M%3BYe%2C+Zhiping&rft.aulast=Adamo&rft.aufirst=Joan&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Melamine Contaminated Animal Feed Recalls T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41067328; 4917589 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Alewynse, M G Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Animal feeds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41067328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Melamine+Contaminated+Animal+Feed+Recalls&rft.au=Alewynse%2C+M+G&rft.aulast=Alewynse&rft.aufirst=M&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Clostridium botulinum Type A Neurotoxin in Milk by High Pressure Processing T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41066208; 4917328 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Schlesser, J E AU - Gerdes, R AU - Skinner, G E AU - Reddy, N R AU - Parisi, B Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Neurotoxins KW - Inactivation KW - Milk KW - Pressure KW - Clostridium botulinum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41066208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Inactivation+of+Clostridium+botulinum+Type+A+Neurotoxin+in+Milk+by+High+Pressure+Processing&rft.au=Schlesser%2C+J+E%3BGerdes%2C+R%3BSkinner%2C+G+E%3BReddy%2C+N+R%3BParisi%2C+B&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDAs Food Protection Plan and Import Safety Plan T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41063163; 4917590 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Benz, S A Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Imports KW - FDA KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=FDAs+Food+Protection+Plan+and+Import+Safety+Plan&rft.au=Benz%2C+S+A&rft.aulast=Benz&rft.aufirst=S&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. AN - 69227057; 17956852 AB - Chronic beryllium disease (CBD) is a granulomatous lung disease that occurs primarily in workers who are exposed to beryllium dust or fumes. Although exposure to beryllium is a necessary factor in the pathobiology of CBD, alleles that code for a glutamic acid residue at the 69th position of the HLA-DPbeta1 gene have previously been found to be associated with CBD. To date, 43 HLA-DPbeta1 alleles that code for glutamic acid 69 (E69) have been described. Whether all of these E69 coding alleles convey equal risk of CBD is unknown. The present study demonstrates that, on the one hand, E69 alleloforms of major histocompatibility complex class II antigen-presenting proteins with the greatest negative surface charge convey the highest risk of CBD, and on the other hand, irrespective of allele, they convey equal risk of beryllium sensitization (BeS). In addition, the data suggest that the same alleles that cause the greatest risk of CBD are also important for the progression from BeS to CBD. Alleles convey the highest risk code for E26 in a constant region and for E69, aspartic acid 55 (D55), E56, D84 and E85 in hypervariable regions of the HLA-DPbeta1 chain. Together with the calculated high binding affinities for beryllium, these results suggest that an adverse immune response, leading to CBD, is triggered by chemically specific metal-protein interactions. JF - Journal of the Royal Society, Interface AU - Snyder, James A AU - Demchuk, Eugene AU - McCanlies, Erin C AU - Schuler, Christine R AU - Kreiss, Kathleen AU - Andrew, Michael E AU - Frye, Bonnie L AU - Ensey, James S AU - Stanton, Marcia L AU - Weston, Ainsley AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2008/07/06/ PY - 2008 DA - 2008 Jul 06 SP - 749 EP - 758 VL - 5 IS - 24 SN - 1742-5689, 1742-5689 KW - HLA-DR Antigens KW - 0 KW - HLA-DRB1 Chains KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Alleles KW - Risk Factors KW - Humans KW - Occupational Exposure -- adverse effects KW - Protein Binding -- genetics KW - Chronic Disease KW - Protein Binding -- immunology KW - Male KW - Female KW - Surface Properties KW - Berylliosis -- immunology KW - Berylliosis -- metabolism KW - HLA-DR Antigens -- immunology KW - Beryllium -- metabolism KW - HLA-DR Antigens -- genetics KW - HLA-DR Antigens -- metabolism KW - Models, Biological KW - Berylliosis -- genetics KW - Amino Acid Substitution KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69227057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Society%2C+Interface&rft.atitle=Impact+of+negatively+charged+patches+on+the+surface+of+MHC+class+II+antigen-presenting+proteins+on+risk+of+chronic+beryllium+disease.&rft.au=Snyder%2C+James+A%3BDemchuk%2C+Eugene%3BMcCanlies%2C+Erin+C%3BSchuler%2C+Christine+R%3BKreiss%2C+Kathleen%3BAndrew%2C+Michael+E%3BFrye%2C+Bonnie+L%3BEnsey%2C+James+S%3BStanton%2C+Marcia+L%3BWeston%2C+Ainsley&rft.aulast=Snyder&rft.aufirst=James&rft.date=2008-07-06&rft.volume=5&rft.issue=24&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Society%2C+Interface&rft.issn=17425689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-22 N1 - Date created - 2008-06-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Allergy Asthma Immunol. 2003 May;90(5 Suppl 2):24-7 [12772947] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 Feb;38(2):439-69 [12638707] Environ Health Perspect. 2003 Nov;111(15):1827-34 [14630515] Risk Anal. 2003 Dec;23(6):1211-20 [14641896] J Immunol. 2003 Dec 15;171(12):6910-8 [14662898] Lancet. 2004 Feb 7;363(9407):415-6 [14962519] Nat Genet. 2004 Jul;36(7):664 [15226743] Am J Ind Med. 2004 Aug;46(2):95-103 [15273960] Am J Ind Med. 2004 Nov;46(5):453-62 [15490468] J Occup Med. 1991 Jan;33(1):23-8 [1995798] Science. 1993 Oct 8;262(5131):242-4 [8105536] Int Immunol. 1995 Oct;7(10):1585-91 [8562503] Am J Ind Med. 1997 Oct;32(4):337-40 [9258386] J Immunol. 1999 Aug 1;163(3):1647-53 [10415070] Tissue Antigens. 2004 Dec;64(6):631-49 [15546336] Am J Respir Crit Care Med. 2005 Jan 1;171(1):54-60 [15374840] J Occup Environ Hyg. 2004 Oct;1(10):648-59 [15631056] J Occup Environ Hyg. 2005 Jun;2(6):D48-50 [16020086] DNA Seq. 2005 Jun;16(3):235-6 [16147881] Mutat Res. 2005 Dec 30;592(1-2):68-78 [16054169] Proteomics. 2006 Mar;6(5):1663-75 [16447159] Annu Rev Public Health. 2007;28:259-77 [17094767] Angew Chem Int Ed Engl. 2007;46(15):2669-71 [17348063] J Phys Chem B. 2007 Mar 22;111(11):2873-85 [17388420] Tissue Antigens. 2007 Mar;69(3):290-2 [17493161] J Phys Chem B. 2007 Jun 14;111(23):6425-36 [17508737] Risk Anal. 2000 Feb;20(1):87-99 [10795342] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22 [11050177] Appl Occup Environ Hyg. 2001 May;16(5):559-67 [11370935] Toxicology. 2001 Aug 13;165(1):27-38 [11551429] Eur Respir J. 2001 Oct;18(4):677-84 [11716174] Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 [11897645] Nucleic Acids Res. 2003 Jan 1;31(1):311-4 [12520010] Am J Epidemiol. 2003 Mar 1;157(5):388-98 [12615603] Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun;20(2):144-8 [12870725] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides AN - 19891878; 8339968 AB - We recently described a novel antimicrobial peptide, RTA3, derived from the commensal organism Streptococcus mitis, with strong anti-Gram-negative activity, low salt sensitivity, and minimal mammalian cell toxicity in vitro and in vivo. This peptide conforms to the positively charged, amphipathic helical peptide motif, but has a positively charged amino acid (Arg-5) on the nonpolar face of the helical structure that is induced upon membrane binding. We surmised that disruption of the hydrophobic face with a positively charged residue plays a role in minimizing eukaryotic cell toxicity, and we tested this using a mutant with an R5L substitution. The greatly enhanced toxicity in the mutant peptide correlated with its ability to bind and adopt helical conformations upon interacting with neutral membranes; the wild type peptide RTA3 did not bind to neutral membranes (binding constant reduced by at least 1000-fold). Spectroscopic analysis indicates that disruption of the hydrophobic face of the parent peptide is accommodated in negatively charged membranes without partial peptide unfolding. These observations apply generally to amphipathic helical peptides of this class as we obtained similar results with a peptide and mutant pair (Chen, Y., Mant, C. T., Farmer, S. W., Hancock, R. E., Vasil, M. L., and Hodges, R. S. (2005) J. Biol. Chem. 280, 12316-12329) having similar structural properties. In contrast to previous interpretations, we demonstrate that these peptides simply do not bind well to membranes (like those of eukaryotes) with exclusively neutral lipids in their external bilayer leaflet. We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides. JF - Journal of Biological Chemistry AU - Hawrani, Ayman AU - Howe, Robin A AU - Walsh, Timothy R AU - Dempsey, Christopher E AD - Biochemistry Department and Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD, National Public Health Service Cardiff, University Hospital of Wales, Cardiff CF14 4XW, and the Department of Medical Microbiology, Cardiff University, Cardiff CF14 4XN, United Kingdom Y1 - 2008/07/04/ PY - 2008 DA - 2008 Jul 04 SP - 18636 EP - 18645 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 27 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts KW - Tryptophan KW - Amino acids KW - Lipids KW - Commensals KW - Hydrophobicity KW - Toxicity KW - Antimicrobial agents KW - Salts KW - Mammalian cells KW - Streptococcus mitis KW - Antimicrobial peptides KW - Conformation KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - X 24310:Pharmaceuticals KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Origin+of+Low+Mammalian+Cell+Toxicity+in+a+Class+of+Highly+Active+Antimicrobial+Amphipathic+Helical+Peptides&rft.au=Hawrani%2C+Ayman%3BHowe%2C+Robin+A%3BWalsh%2C+Timothy+R%3BDempsey%2C+Christopher+E&rft.aulast=Hawrani&rft.aufirst=Ayman&rft.date=2008-07-04&rft.volume=283&rft.issue=27&rft.spage=18636&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tryptophan; Salts; Amino acids; Mammalian cells; Lipids; Commensals; Hydrophobicity; Toxicity; Antimicrobial peptides; Antimicrobial agents; Conformation; Streptococcus mitis ER - TY - CPAPER T1 - Accuracy of Impression Techniques for an Implant-Supported Prosthesis T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40980966; 4877943 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Del'acqua, M A AU - Chavez, A M AU - Mollo-Junior, F.D.A. AU - Compagnoni, M A AU - Nogueira, S S AU - Arioli-Filho, J N Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Face KW - Maxilla UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40980966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Accuracy+of+Impression+Techniques+for+an+Implant-Supported+Prosthesis&rft.au=Del%27acqua%2C+M+A%3BChavez%2C+A+M%3BMollo-Junior%2C+F.D.A.%3BCompagnoni%2C+M+A%3BNogueira%2C+S+S%3BArioli-Filho%2C+J+N&rft.aulast=Del%27acqua&rft.aufirst=M&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of the Index and Three Techniques for Abutment Impressions T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40974047; 4877944 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Chavez, A M AU - Mollo, F.D.A. AU - Nogueira, S S AU - Filho, J.N. Arioli AU - Del'acqua, M A Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Face KW - Maxilla UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40974047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Accuracy+of+the+Index+and+Three+Techniques+for+Abutment+Impressions&rft.au=Chavez%2C+A+M%3BMollo%2C+F.D.A.%3BNogueira%2C+S+S%3BFilho%2C+J.N.+Arioli%3BDel%27acqua%2C+M+A&rft.aulast=Chavez&rft.aufirst=A&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Human Salivary Gland Stem/Progenitor Cells (SGSC) T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40973057; 4878062 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Yoshizawa, S AU - Mineshiba, J AU - Weigert, R AU - Aye, M P AU - Robey, P G Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Salivary gland KW - Stem cells KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40973057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Characterization+of+Human+Salivary+Gland+Stem%2FProgenitor+Cells+%28SGSC%29&rft.au=Yoshizawa%2C+S%3BMineshiba%2C+J%3BWeigert%2C+R%3BAye%2C+M+P%3BRobey%2C+P+G&rft.aulast=Yoshizawa&rft.aufirst=S&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - What do we know about hearing protector comfort? AN - 85407365; pmid-19052440 AB - The purpose of the present article is to review comfort studies on hearing protector devices. Comfort is probably the most important dimension for long-term worker acceptance and effective wear of hearing protectors in noise. A short digression has been made to introduce comfort work from the textile and clothing industries where models of comfort have been attempted and comfort research is much more sophisticated. Finally, presented are some recent efforts by NIOSH to examine issues of hearing protector comfort in greater detail. These efforts include a field study of a semi-custom earplug hearing protector. JF - Noise & health AU - Davis, Rickie R AD - Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. rrd1@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 83 EP - 89 VL - 10 IS - 40 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Consumer Satisfaction KW - *Ear Protective Devices: standards KW - Equipment Design KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Health KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85407365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=What+do+we+know+about+hearing+protector+comfort%3F&rft.au=Davis%2C+Rickie+R&rft.aulast=Davis&rft.aufirst=Rickie&rft.date=2008-07-01&rft.volume=10&rft.issue=40&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The National Institute for Occupational Safety and Health Radiation Dose Reconstruction Program: commentary and conclusions. AN - 71661765; 18545038 JF - Health physics AU - Neton, James W AU - Elliott, Larry J AD - National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA. jneton@cdc.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 160 EP - 163 VL - 95 IS - 1 KW - Radioactive Pollutants KW - 0 KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Risk Factors KW - Humans KW - Workers' Compensation KW - Data Collection KW - Quality Control KW - Radiation Injuries KW - Occupational Health -- legislation & jurisprudence KW - Radiation Dosage KW - Occupational Exposure -- prevention & control KW - Radiation Monitoring -- methods KW - Occupational Exposure -- standards KW - Occupational Exposure -- adverse effects KW - Radioactive Pollutants -- toxicity KW - Risk Assessment -- methods KW - National Institute for Occupational Safety and Health (U.S.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71661765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=The+National+Institute+for+Occupational+Safety+and+Health+Radiation+Dose+Reconstruction+Program%3A+commentary+and+conclusions.&rft.au=Neton%2C+James+W%3BElliott%2C+Larry+J&rft.aulast=Neton&rft.aufirst=James&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2F01.HP.0000311550.43768.48 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-16 N1 - Date created - 2008-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.HP.0000311550.43768.48 ER - TY - JOUR T1 - Alcohol use, injuries, and prenatal visits during three successive pregnancies among American Indian women on the Northern Plains who have children with fetal alcohol syndrome or incomplete fetal alcohol syndrome. AN - 69605547; 18498046 AB - The purpose of the study was to compare three sequential pregnancies of American Indian women who have children with FAS or children with incomplete FAS with women who did not have children with FAS. Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome (FAS) (Study 1) or incomplete FAS (Study 2) in 1981-1993. Three successive pregnancies ending in live births of 43 case mothers who had children with FAS, and 35 case mothers who had children with incomplete FAS were compared to the pregnancies of 86 and 70 control mothers who did not have children with FAS, respectively, in the two studies. Prenatal records were abstracted for the index child (child with FAS or incomplete FAS) and siblings born just before and just after the index child, and comparable prenatal records for the controls. Compared to the controls, significantly more case mothers used alcohol before and after all three pregnancies and during pregnancy with the before sibling and the index child. Mothers who had children with FAS reduced their alcohol use during the pregnancy following the birth of the index child. All Study 1 case mothers (100%) and 60% of Study 2 case mothers used alcohol during the pregnancy with the index child compared to 20 and 9% of respective control mothers. More study 1 case mothers experienced unintentional injuries (OR 9.50) and intentional injuries during the index pregnancy (OR 9.33) than the control mothers. Most case mothers began prenatal care in the second trimester. Alcohol use was documented before, during and after each of the three pregnancies. Women of child-bearing age should be screened for alcohol use whenever they present for medical services. Mothers who had a child with FAS decreased their alcohol consumption with the next pregnancy, a finding that supports the importance of prenatal screening throughout pregnancy. Women who receive medical care for injuries should be screened for alcohol use and referred for appropriate treatment. Protective custody, case management and treatment services need to be readily available for women who use alcohol. JF - Maternal and child health journal AU - Kvigne, Valborg L AU - Leonardson, Gary R AU - Borzelleca, Joseph AU - Brock, Ellen AU - Neff-Smith, Martha AU - Welty, Thomas K AD - Aberdeen Area Indian Health Service, 2013 W 15th St #1, Sioux Falls, SD 57104, USA. kvig6@aol.com Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 37 EP - 45 VL - 12 Suppl 1 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Montana -- epidemiology KW - Adult KW - Retrospective Studies KW - Case-Control Studies KW - South Dakota -- epidemiology KW - Confidence Intervals KW - Middle Aged KW - Female KW - Pregnancy KW - Prenatal Care -- statistics & numerical data KW - Indians, North American -- statistics & numerical data KW - Alcohol Drinking -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69605547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+child+health+journal&rft.atitle=Alcohol+use%2C+injuries%2C+and+prenatal+visits+during+three+successive+pregnancies+among+American+Indian+women+on+the+Northern+Plains+who+have+children+with+fetal+alcohol+syndrome+or+incomplete+fetal+alcohol+syndrome.&rft.au=Kvigne%2C+Valborg+L%3BLeonardson%2C+Gary+R%3BBorzelleca%2C+Joseph%3BBrock%2C+Ellen%3BNeff-Smith%2C+Martha%3BWelty%2C+Thomas+K&rft.aulast=Kvigne&rft.aufirst=Valborg&rft.date=2008-07-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Maternal+and+child+health+journal&rft.issn=1573-6628&rft_id=info:doi/10.1007%2Fs10995-008-0367-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-05 N1 - Date created - 2008-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10995-008-0367-8 ER - TY - JOUR T1 - Early communication about an ongoing safety review Botox and Botox Cosmetic (botulinum toxin type A) and Myobloc (botulinum toxin type B). AN - 69554305; 18794742 JF - Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses AU - U.S. Food and Drug Administration AD - U.S. Food and Drug Administration PY - 2008 SP - 150 EP - 151 VL - 28 IS - 3 SN - 0741-5206, 0741-5206 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Metalloendopeptidases KW - EC 3.4.24.- KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Product Surveillance, Postmarketing KW - Drug Labeling KW - Botulinum Toxins, Type A -- adverse effects KW - Botulinum Toxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69554305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+surgical+nursing+%3A+official+journal+of+the+American+Society+of+Plastic+and+Reconstructive+Surgical+Nurses&rft.atitle=Early+communication+about+an+ongoing+safety+review+Botox+and+Botox+Cosmetic+%28botulinum+toxin+type+A%29+and+Myobloc+%28botulinum+toxin+type+B%29.&rft.au=U.S.+Food+and+Drug+Administration&rft.aulast=U.S.+Food+and+Drug+Administration&rft.aufirst=&rft.date=2008-07-01&rft.volume=28&rft.issue=3&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Plastic+surgical+nursing+%3A+official+journal+of+the+American+Society+of+Plastic+and+Reconstructive+Surgical+Nurses&rft.issn=07415206&rft_id=info:doi/10.1097%2F01.PSN.0000335818.00036.c5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2008-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.PSN.0000335818.00036.c5 ER - TY - JOUR T1 - Asbestosis mortality surveillance in the United States, 1970-2004. AN - 69404549; 18686715 AB - To describe the demographic, geographic, and occupational distribution of asbestosis mortality in the United States during 1970-2004, we identified a total of 25,413 asbestosis deaths. We calculated national, state, and county death rates, age-adjusted to the 2000 U.S. standard population. We also calculated industry- and occupation-specific proportionate mortality ratios (PMRs), adjusted for age, sex, and race, and corresponding confidence intervals (CIs) using available data. The overall U.S. age-adjusted asbestosis death rate was 4.1 per million population per year; the rate for males (10.4) was nearly 35-fold higher than that for females (0.3). It increased significantly from 0.6 to 6.9 per million population from 1970 to 2000 (p<0.001), and then declined to 6.3 in 2004 (p=0.014). High asbestosis death rates occurred predominantly, though not exclusively, in coastal areas. Industries with highest PMRs included ship and boat building and repairing (18.5; 95% CI 16.3-20.9) and miscellaneous nonmetallic mineral and stone products (15.9; 95% CI 13.0-19.5). Occupations with highest PMRs included insulation workers (109.2; 95% CI 93.8-127.2) and boilermakers (21.3; 95% CI 17.0-26.6). JF - International journal of occupational and environmental health AU - Bang, Ki Moon AU - Mazurek, Jacek M AU - Syamlal, Girija AU - Wood, John M AD - Division of Respiratory Disease Studies, RM H-G900.2, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. kmb2@cdc.gov PY - 2008 SP - 161 EP - 169 VL - 14 IS - 3 SN - 1077-3525, 1077-3525 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Occupations KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Population Surveillance KW - Asbestosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69404549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Asbestosis+mortality+surveillance+in+the+United+States%2C+1970-2004.&rft.au=Bang%2C+Ki+Moon%3BMazurek%2C+Jacek+M%3BSyamlal%2C+Girija%3BWood%2C+John+M&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2008-07-01&rft.volume=14&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Feasibility of detection and quantification of gas-phase carbonyls in indoor environments using PFBHA derivatization and solid-phase microextraction (SPME). AN - 69402163; 18688453 AB - Solid-phase microextraction (SPME) was evaluated for the detection and quantification of the gas-phase carbonyls: citronellal, glyoxal, methylglyoxal, and beta-ionone. Prepared air samples containing the carbonyl compounds were collected at a flow rate of 2.8 L min(-1) in an impinger containing a 25% reagent water/75% methanol collection liquid. The aqueous samples were then derivatized with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA), extracted with a PDMS/DVB coated SPME fiber, and analyzed by GC-MS. Detection limits with a sample air volume of 76 L were calculated to be 0.03 ppbv, 0.34 ppbv, 0.12 ppbv, and 0.28 ppbv for citronellal, glyoxal, methylglyoxal, and beta-ionone, respectively. JF - Journal of environmental monitoring : JEM AU - Pacolay, Bruce D AU - Ham, Jason E AU - Slaven, James E AU - Wells, J R AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505, USA. Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 853 EP - 860 VL - 10 IS - 7 KW - Air Pollutants KW - 0 KW - Gases KW - Hydrocarbons KW - Hydroxylamines KW - Florox Reagent KW - 57981-02-9 KW - Index Medicus KW - Hydrocarbons -- chemistry KW - Air Pollution, Indoor -- analysis KW - Gases -- analysis KW - Hydroxylamines -- chemistry KW - Air Pollutants -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69402163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Feasibility+of+detection+and+quantification+of+gas-phase+carbonyls+in+indoor+environments+using+PFBHA+derivatization+and+solid-phase+microextraction+%28SPME%29.&rft.au=Pacolay%2C+Bruce+D%3BHam%2C+Jason+E%3BSlaven%2C+James+E%3BWells%2C+J+R&rft.aulast=Pacolay&rft.aufirst=Bruce&rft.date=2008-07-01&rft.volume=10&rft.issue=7&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb801926f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-03 N1 - Date created - 2008-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b801926f ER - TY - JOUR T1 - Mold(2), molecular descriptors from 2D structures for chemoinformatics and toxicoinformatics. AN - 69362851; 18564836 AB - Research applications in chemoinformatics and toxicoinformatics increasingly use representations of molecules in the form of numerical descriptors that capture the structural characteristics and properties of molecules. These representations are useful for ADME/toxicity prediction, diversity analysis, library design, QSAR/QSPR, virtual screening, and other purposes. Molecular descriptors have ranged from relatively simple forms calculated from simple two-dimensional (2D) chemical structures to more complex forms representing three-dimensional (3D) chemical structures or complex molecular fingerprints consisting of numerous bit positions to represent specific chemical information. The Mold (2) software was developed to enable the rapid calculation of a large and diverse set of descriptors encoding two-dimensional chemical structure information. Comparative analysis of Mold (2) descriptors with those calculated by Cerius (2), Dragon, and Molconn-Z on several data sets using Shannon entropy analysis demonstrated that Mold (2) descriptors convey a similar amount of information. In addition, using the same classification method, slightly better models were generated using Mold (2) descriptors compared to those generated using descriptors from the compared commercial software packages. The low computing cost for Mold (2) makes it suitable not only for small data sets, such as in QSAR, but also for large databases in virtual screening. High reproducibility and reliability are expected because Mold (2) does not require 3D structures. Mold (2) is freely available to the public ( http://www.fda.gov/nctr/science/centers/toxicoinformatics/index.htm). JF - Journal of chemical information and modeling AU - Hong, Huixiao AU - Xie, Qian AU - Ge, Weigong AU - Qian, Feng AU - Fang, Hong AU - Shi, Leming AU - Su, Zhenqiang AU - Perkins, Roger AU - Tong, Weida AD - Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. huixiao.hong@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 1337 EP - 1344 VL - 48 IS - 7 SN - 1549-9596, 1549-9596 KW - Index Medicus KW - Molecular Structure KW - Quantitative Structure-Activity Relationship KW - Information Systems KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69362851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Mold%282%29%2C+molecular+descriptors+from+2D+structures+for+chemoinformatics+and+toxicoinformatics.&rft.au=Hong%2C+Huixiao%3BXie%2C+Qian%3BGe%2C+Weigong%3BQian%2C+Feng%3BFang%2C+Hong%3BShi%2C+Leming%3BSu%2C+Zhenqiang%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2008-07-01&rft.volume=48&rft.issue=7&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=15499596&rft_id=info:doi/10.1021%2Fci800038f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ci800038f ER - TY - JOUR T1 - An innovative approach to determine fetal risk: the FDA Office of Women's Health pregnancy exposure registry web listing. AN - 69280625; 18468921 JF - Women's health issues : official publication of the Jacobs Institute of Women's Health AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Uhl, Kathleen AD - Food and Drug Administration, Office of Women's Health, Rockville, Maryland, USA. pellavi.sharma@fda.hhs.gov PY - 2008 SP - 226 EP - 228 VL - 18 IS - 4 SN - 1049-3867, 1049-3867 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Maternal Exposure -- prevention & control KW - Prenatal Care -- legislation & jurisprudence KW - Humans KW - Adult KW - Health Policy KW - Female KW - Pregnancy KW - Registries KW - Internet -- legislation & jurisprudence KW - Prenatal Exposure Delayed Effects -- prevention & control KW - Prenatal Diagnosis -- methods KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69280625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.atitle=An+innovative+approach+to+determine+fetal+risk%3A+the+FDA+Office+of+Women%27s+Health+pregnancy+exposure+registry+web+listing.&rft.au=Sharma%2C+Pellavi%3BParekh%2C+Ameeta%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2008-07-01&rft.volume=18&rft.issue=4&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2008.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-17 N1 - Date created - 2008-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.whi.2008.02.006 ER - TY - JOUR T1 - Cocaine-like neurochemical effects of antihistaminic medications. AN - 69278954; 18363822 AB - The pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H(1) histamine antagonists which have behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-chlorpheniramine were compared with triprolidine, a potent and selective H(1) antagonist and (-)-chlorpheniramine which is less active than its enantiomer at H(1) receptors. Affinities of the drugs to DA, serotonin, and norepinephrine transporters at H(1) receptors and potencies for DA uptake inhibition in striatal synaptosomes were determined to assess mechanisms by which the compounds increased DA levels. Intravenous diphenhydramine (1.0-3.0 mg/kg) (+)- and (-)-chlorpheniramine (1.0-5.6 mg/kg) but not triprolidine (1.0-3.0 mg/kg) elicited a cocaine-like pattern of stimulation of DA transmission with larger effects in the NAc shell than core. The absence of stereospecific effects with chlorpheniramine enantiomers along with the lack of an effect with triprolidine suggest that the effects on DA transmission were not related to H(1) receptor antagonism. Although in vivo potencies were not directly related to DA transporter affinities, it is hypothesized that actions at that site modulated by other actions, possibly those at the serotonin transporter, are primarily responsible for the neurochemical actions of the drugs on DA neurotransmission and might underlie the occasional misuse of these medications. JF - Journal of neurochemistry AU - Tanda, Gianluigi AU - Kopajtic, Theresa A AU - Katz, Jonathan L AD - Psychobiology Section, Medications Discovery Research Branch, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. gtanda@intra.nida.nih.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 147 EP - 157 VL - 106 IS - 1 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Agonists KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Histamine H1 Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Triprolidine KW - 2L8T9S52QM KW - Chlorpheniramine KW - 3U6IO1965U KW - Diphenhydramine KW - 8GTS82S83M KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Stereoisomerism KW - Synaptosomes -- drug effects KW - Serotonin Plasma Membrane Transport Proteins -- drug effects KW - Triprolidine -- pharmacology KW - Presynaptic Terminals -- metabolism KW - Rats KW - Presynaptic Terminals -- drug effects KW - Reward KW - Substance-Related Disorders -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- drug effects KW - Male KW - Dopamine Uptake Inhibitors -- agonists KW - Substance-Related Disorders -- physiopathology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Synaptic Transmission -- drug effects KW - Chlorpheniramine -- pharmacology KW - Triprolidine -- adverse effects KW - Synaptic Transmission -- physiology KW - Rats, Sprague-Dawley KW - Chlorpheniramine -- adverse effects KW - Diphenhydramine -- pharmacology KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Diphenhydramine -- adverse effects KW - Synaptosomes -- metabolism KW - Central Nervous System Stimulants -- pharmacology KW - Nucleus Accumbens -- drug effects KW - Dopamine Agonists -- pharmacology KW - Histamine H1 Antagonists -- pharmacology KW - Cocaine -- agonists KW - Nucleus Accumbens -- metabolism KW - Histamine H1 Antagonists -- adverse effects KW - Dopamine Agonists -- adverse effects KW - Dopamine -- metabolism KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69278954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Trans+Fat+Labeling+and+Regulations&rft.au=Moss%2C+J&rft.aulast=Moss&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2008.05361.x ER - TY - JOUR T1 - Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. AN - 69277301; 18373618 AB - Localized tumor necrosis factor-alpha (TNFalpha) elevation has diverse effects in brain injury often attributed to signaling via TNFp55 or TNFp75 receptors. Both dentate granule cells and CA pyramidal cells express TNF receptors (TNFR) at low levels in a punctate pattern. Using a model to induce selective death of dentate granule cells (trimethyltin; 2 mg/kg, i.p.), neuronal apoptosis [terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ end labeling, active caspase 3 (AC3)] was accompanied by amoeboid microglia and elevated TNFalpha mRNA levels. TNFp55R (55 kDa type-1 TNFR) and TNFp75R (75 kDa type-2 TNFR) immunoreactivity in AC3(+) neurons displayed a pattern suggestive of receptor internalization and a temporal sequence of expression of TNFp55R followed by TNFp75R associated with the progression of apoptosis. A distinct ramified microglia response occurred around CA1 neurons and healthy dentate neurons that displayed an increase in the normal punctate pattern of TNFRs. Neuronal damage was decreased with i.c.v. injection of TNFalpha antibody and in TNFp55R-/-p75R-/- mice that showed higher constitutive mRNA levels for interleukin (IL-1alpha), macrophage inflammatory protein 1-alpha (MIP-1alpha), TNFalpha, transforming growth factor beta1, Fas, and TNFRSF6-assoicated via death domain (FADD). TNFp75R-/- mice showed exacerbated injury and elevated mRNA levels for IL-1alpha, MIP-1alpha, and TNFalpha. In TNFp55R-/- mice, constitutive mRNA levels for TNFalpha, IL-6, caspase 8, FADD, and Fas-associated phosphatase were higher; IL-1alpha, MIP-1alpha, and transforming growth factor beta1 lower. The mice displayed exacerbated neuronal death, delayed microglia response, increased FADD and TNFp75R mRNA levels, and co-expression of TNFp75R in AC3(+) neurons. The data demonstrate TNFR-mediated apoptotic death of dentate granule neurons utilizing both TNFRs and suggest a TNFp75R-mediated apoptosis in the absence of normal TNFp55R activity. JF - Journal of neurochemistry AU - Harry, G Jean AU - Lefebvre d'Hellencourt, Christian AU - McPherson, Christopher A AU - Funk, Jason A AU - Aoyama, Mineyoshi AU - Wine, Robert N AD - Department of Health and Human Services, Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. harry@niehs.nih.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 281 EP - 298 VL - 106 IS - 1 KW - Apoptosis Regulatory Proteins KW - 0 KW - Cytokines KW - Fadd protein, mouse KW - Fas-Associated Death Domain Protein KW - Neurotoxins KW - Receptors, Nerve Growth Factor KW - Receptors, Tumor Necrosis Factor KW - Receptors, Tumor Necrosis Factor, Type I KW - TNFRSF16 protein, mouse KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Index Medicus KW - Animals KW - Fas-Associated Death Domain Protein -- genetics KW - Cytokines -- drug effects KW - Cytokines -- genetics KW - Apoptosis Regulatory Proteins -- genetics KW - Apoptosis Regulatory Proteins -- drug effects KW - Mice KW - Cytokines -- metabolism KW - Trimethyltin Compounds -- toxicity KW - Neurotoxins -- toxicity KW - Mice, Knockout KW - Microglia -- immunology KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Endocytosis -- drug effects KW - Fas-Associated Death Domain Protein -- drug effects KW - Fas-Associated Death Domain Protein -- metabolism KW - Microglia -- drug effects KW - Endocytosis -- physiology KW - Male KW - Receptors, Nerve Growth Factor -- genetics KW - Dentate Gyrus -- immunology KW - Neurons -- metabolism KW - Nerve Degeneration -- immunology KW - Neurons -- drug effects KW - Dentate Gyrus -- metabolism KW - Apoptosis -- immunology KW - Nerve Degeneration -- chemically induced KW - Receptors, Tumor Necrosis Factor, Type I -- drug effects KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Receptors, Tumor Necrosis Factor, Type I -- genetics KW - Receptors, Nerve Growth Factor -- metabolism KW - Receptors, Tumor Necrosis Factor, Type I -- metabolism KW - Receptors, Nerve Growth Factor -- drug effects KW - Dentate Gyrus -- pathology KW - Nerve Degeneration -- metabolism KW - Apoptosis -- drug effects KW - Receptors, Tumor Necrosis Factor -- metabolism KW - Neurons -- immunology KW - Receptors, Tumor Necrosis Factor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69277301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Tumor+necrosis+factor+p55+and+p75+receptors+are+involved+in+chemical-induced+apoptosis+of+dentate+granule+neurons.&rft.au=Harry%2C+G+Jean%3BLefebvre+d%27Hellencourt%2C+Christian%3BMcPherson%2C+Christopher+A%3BFunk%2C+Jason+A%3BAoyama%2C+Mineyoshi%3BWine%2C+Robert+N&rft.aulast=Harry&rft.aufirst=G&rft.date=2008-07-01&rft.volume=106&rft.issue=1&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2008.05382.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2008.05382.x ER - TY - JOUR T1 - Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9. AN - 69270142; 18059068 AB - Androstenedione, a naturally occurring steroid hormone, has been used to enhance athletic performance. Little is known, however, about its hepatotoxicity. Clone-9 cells, a non-transformed epithelial cell line that was originally isolated from normal liver of a 4-week old Sprague-Dawley rat, were used as an in vitro model to assess the hepatotoxic potential of androstenedione. The cultures were treated with androstenedione for 24 h at 37 degrees C in 5% CO(2) at concentrations of 0-100 microg ml(-1). After the treatment period, the cells and the culture supernatants were assayed for markers of cytotoxicity which included: release of liver enzymes, cell viability, cellular double-stranded DNA content, oxidative stress, steatosis, cellular ATP content, caspase-3 activity, the mitochondrial permeability transition and induction of cytochrome P450 activity. Significant concentration-dependent differences from control were observed in some endpoints at medium concentrations of 10 microg ml(-1) and above. These in vitro findings were compared with comparable endpoints obtained from an in vivo study of androstenedione toxicity in female Sprague-Dawley rats. Of the eight endpoints that could be compared between the two studies, only three (lipid accumulation, ATP depletion and P450 activity) appeared to be concordant. This suggests that, under the experimental conditions used, the clone-9 cells were not a good model for androstenedione hepatotoxicity. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Wiesenfeld, Paddy L AU - Kim, Chung S AU - Ross, Ivan A AU - Sapienza, Philip P AU - Newell, Richard AU - O'Donnell, Michael W AU - Flynn, Thomas J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, U. S. Food and Drug Administration, Laurel, MD 20708, USA. saura.sahu@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 703 EP - 709 VL - 28 IS - 5 SN - 0260-437X, 0260-437X KW - Biomarkers KW - 0 KW - Enzymes KW - Androstenedione KW - 409J2J96VR KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - DNA KW - 9007-49-2 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Clone Cells KW - Animals KW - Liver -- pathology KW - Liver -- cytology KW - Hepatocytes -- drug effects KW - Reproducibility of Results KW - Enzymes -- metabolism KW - Hepatocytes -- enzymology KW - Models, Biological KW - DNA -- biosynthesis KW - Rats KW - Rats, Sprague-Dawley KW - Enzymes -- blood KW - Liver -- drug effects KW - Adenosine Triphosphate -- metabolism KW - DNA -- genetics KW - Oxidative Stress -- drug effects KW - Cell Line KW - Female KW - Caspase 3 -- metabolism KW - Chemical and Drug Induced Liver Injury -- pathology KW - Androstenedione -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69270142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Validation+of+an+in+vitro+model+for+assessment+of+androstenedione+hepatotoxicity+using+the+rat+liver+cell+line+clone-9.&rft.au=Sahu%2C+Saura+C%3BWiesenfeld%2C+Paddy+L%3BKim%2C+Chung+S%3BRoss%2C+Ivan+A%3BSapienza%2C+Philip+P%3BNewell%2C+Richard%3BO%27Donnell%2C+Michael+W%3BFlynn%2C+Thomas+J&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2008-07-01&rft.volume=28&rft.issue=5&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age-related differences in susceptibility to toxic effects of valproic acid in rats. AN - 69266982; 17994530 AB - A multi-age rat model was evaluated as a means to identify a potential age-related difference in liver injury following exposure to valproic acid (VPA), a known pediatric hepatotoxic agent. Different age groups of Sprague-Dawley (SD) rats (10-, 25-, 40-, 80-day-old) were administered VPA at doses of 160, 320, 500 or 650 mg kg(-1) (i.p.) for 4 days. Animals from all age groups developed toxicity after treatment with VPA; however, the patterns of toxicity were dissimilar within each age group. The high dose of VPA caused significant lethality in 10- and 25-day-old rats. All doses of VPA caused decrease in the platelet counts (10-, 25-day-old rats) and the rate of growth (40-day-old rats) and increases in the urine creatine concentration (high dose, 80-day-old rats). VPA induced hepatic and splenic alterations in all age groups. The most severe lesions were found mostly in 10- and 80-day-old rats. Significant changes in blood urea nitrogen, alanine aminotransferase and alkaline phosphatase were observed in 10-day-old pups after treatment with low doses of VPA. The highest VPA dose caused significant decreases in the levels of serum total protein (40- and 80-day-old rats). Principal component analysis of spectra derived from terminal urine samples of all age groups showed that each age group clusters separately. In conclusion, this study showed that the vulnerability profile of each age group was different indicating that a multi-age pediatric animal model is appropriate to assess more completely age-dependent changes in drug toxicity. JF - Journal of applied toxicology : JAT AU - Espandiari, Parvaneh AU - Zhang, Jun AU - Schnackenberg, Laura K AU - Miller, Terry J AU - Knapton, Alan AU - Herman, Eugene H AU - Beger, Richard D AU - Hanig, Joseph P AD - FDA, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA. parvaneh.espandiari@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 628 EP - 637 VL - 28 IS - 5 SN - 0260-437X, 0260-437X KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Blood Chemical Analysis KW - Liver -- pathology KW - Spleen -- pathology KW - Blood Cell Count KW - Magnetic Resonance Spectroscopy KW - Rats KW - Rats, Sprague-Dawley KW - Alanine Transaminase -- blood KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Spleen -- drug effects KW - Female KW - Male KW - Metabolism KW - Organ Size -- drug effects KW - Aging -- physiology KW - Valproic Acid -- toxicity KW - Anticonvulsants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69266982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Age-related+differences+in+susceptibility+to+toxic+effects+of+valproic+acid+in+rats.&rft.au=Espandiari%2C+Parvaneh%3BZhang%2C+Jun%3BSchnackenberg%2C+Laura+K%3BMiller%2C+Terry+J%3BKnapton%2C+Alan%3BHerman%2C+Eugene+H%3BBeger%2C+Richard+D%3BHanig%2C+Joseph+P&rft.aulast=Espandiari&rft.aufirst=Parvaneh&rft.date=2008-07-01&rft.volume=28&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Presence of airborne fibers in tungsten refining and manufacturing processes: preliminary characterization. AN - 69244967; 18569509 AB - In tungsten refining and manufacturing processes, a series of tungsten oxides (WO(X)) are typically formed as intermediates in the production of tungsten powder. Studies in the Swedish tungsten refining and manufacturing industry have shown that intermediate tungsten refining processes can create WO(X) fibers. The purpose of the present study was to identify and provide a preliminary characterization of airborne tungsten-containing fiber dimensions, elemental composition, and concentrations in the U.S. tungsten refining and manufacturing industry. To provide the preliminary characterization, 10 static air samples were collected during the course of normal employee work activities and analyzed using standard fiber sampling and counting methods. Results from transmission electron microscopy analyses conducted indicate that airborne fibers with length > 0.5 microm, diameter > 0.01 microm, and aspect ratio > or = 3:1, with a geometric mean (GM) length of approximately 2.0 microm and GM diameter of approximately 0.25 microm, were present on 9 of the 10 air samples collected. Energy dispersive X-ray spectrometry results indicate that airborne fibers prior to the carburization process consisted primarily of tungsten and oxygen, with other elements being detected in trace quantities. Results from an air sample collected at the carburization process indicated the presence of fibers composed primarily of tungsten with oxygen and carbon, and traces of other elements. Based on National Institute for Occupational Safety and Health standard fiber counting rules, airborne fiber concentrations ranged from below the limit of detection to 0.14 f/cm(3). The calcining process was associated with the highest airborne fiber concentrations. More than 99% (574/578) of the airborne fibers identified had an aerodynamic diameter 0.2 mg/sample) were found on the hands of 61% and 0% of these two groups, respectively, with the highest measured quantity equal to 1.06 mg. Samples from the upper surfaces of automobile motors were generally low to nondetectable (<0.027 mg/sample), while the median value of 0.047 mg/50 cm2(CV = 160%) and up to 0.640 mg were found on the drip pans. JF - Journal of Occupational and Environmental Hygiene AU - Boeniger, Mark AU - Neumeister, Charles AU - Booth-Jones, Angela AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 417 EP - 425 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 7 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - High-performance liquid chromatography KW - polyesters KW - Gasoline KW - Motor vehicles KW - Pyrene KW - corn KW - Oil KW - Workers KW - pyrene KW - Sampling KW - Occupational exposure KW - Environmental hygiene KW - Polycyclic aromatic hydrocarbons KW - Skin KW - Oils KW - Hand KW - Filters KW - Fabrics KW - Liquid chromatography KW - Filter paper KW - Dimethyl sulfoxide KW - polycyclic aromatic hydrocarbons KW - technicians KW - Sampling methods KW - Pans KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Sampling+and+Analytical+Method+Development+and+Hand+Wipe+Measurements+of+Dermal+Exposures+to+Polycyclic+Aromatic+Hydrocarbons&rft.au=Boeniger%2C+Mark%3BNeumeister%2C+Charles%3BBooth-Jones%2C+Angela&rft.aulast=Boeniger&rft.aufirst=Mark&rft.date=2008-07-01&rft.volume=5&rft.issue=7&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802111319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Polycyclic aromatic hydrocarbons; polyesters; Skin; Gasoline; Motor vehicles; Oils; Hand; Pyrene; Fabrics; Workers; Dimethyl sulfoxide; Filter paper; Sampling; Pans; Environmental hygiene; Filters; Oil; pyrene; Liquid chromatography; polycyclic aromatic hydrocarbons; technicians; corn; Sampling methods; Occupational exposure DO - http://dx.doi.org/10.1080/15459620802111319 ER - TY - JOUR T1 - Bam32: a novel mediator of Erk activation in T cells AN - 194972669; 18448454 AB - Bam32 (B lymphocyte adapter molecule of 32 kDa) is an adapter protein expressed in some hematopoietic cells including B and T lymphocytes. It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including B cell receptor (BCR)-induced Erk activation, BCR-induced proliferation and T-independent antibody responses. In this study, we have examined the role of Bam32 in T cell activation using Bam32-deficient mice. By comparing CD4[sup]+ T cells from lymph nodes of wild-type and Bam32-deficient mice, we found that Bam32 was required for optimal TCR-induced Erk activation, cytokine production, proliferation and actin-mediated spreading of CD4[sup]+ T cells. These results indicate a novel pathway to Erk activation in T cells involving the adapter protein Bam32. JF - International Immunology AU - Sommers, Connie L AU - Gurson, Jordan M AU - Surana, Rishi AU - Barda-saad, Mira AU - Lee, Jan AU - Kishor, Aparna AU - Li, Wenmei AU - Gasser, Adam J AU - Barr, Valarie A AU - Miyaji, Michihiko AU - Love, Paul E AU - Samelson, Lawrence E Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 811 EP - 8 CY - Oxford PB - Oxford Publishing Limited(England) VL - 20 IS - 7 SN - 09538178 KW - Medical Sciences--Allergology And Immunology KW - Actins KW - Adaptor Proteins, Signal Transducing KW - Cytokines KW - Dapp1 protein, mouse KW - Lipoproteins KW - Receptors, Antigen, T-Cell KW - Extracellular Signal-Regulated MAP Kinases KW - Animals KW - Adaptor Proteins, Signal Transducing -- immunology KW - Lipoproteins -- immunology KW - Humans KW - Receptors, Antigen, T-Cell -- metabolism KW - Cytokines -- secretion KW - Jurkat Cells KW - Actins -- immunology KW - Mice KW - Cell Proliferation KW - Mice, Knockout KW - Enzyme Activation -- genetics KW - Lymphocyte Activation -- genetics KW - Lipoproteins -- genetics KW - Actins -- genetics KW - Extracellular Signal-Regulated MAP Kinases -- immunology KW - Mice, Inbred C57BL KW - Adaptor Proteins, Signal Transducing -- genetics KW - Cell Adhesion -- immunology KW - Receptors, Antigen, T-Cell -- genetics KW - Signal Transduction KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Lipoproteins -- metabolism KW - CD4-Positive T-Lymphocytes -- metabolism KW - Extracellular Signal-Regulated MAP Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/194972669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Immunology&rft.atitle=Bam32%3A+a+novel+mediator+of+Erk+activation+in+T+cells&rft.au=Sommers%2C+Connie+L%3BGurson%2C+Jordan+M%3BSurana%2C+Rishi%3BBarda-saad%2C+Mira%3BLee%2C+Jan%3BKishor%2C+Aparna%3BLi%2C+Wenmei%3BGasser%2C+Adam+J%3BBarr%2C+Valarie+A%3BMiyaji%2C+Michihiko%3BLove%2C+Paul+E%3BSamelson%2C+Lawrence+E&rft.aulast=Sommers&rft.aufirst=Connie&rft.date=2008-07-01&rft.volume=20&rft.issue=7&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=International+Immunology&rft.issn=09538178&rft_id=info:doi/10.1093%2Fintimm%2Fdxn039 LA - English DB - ProQuest Central N1 - Copyright - Published by Oxford University Press 2008. N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1093/intimm/dxn039 ER - TY - JOUR T1 - Monitoring of brevetoxins in the Karenia brevis bloom-exposed Eastern oyster (Crassostrea virginica) AN - 19480443; 8400236 AB - Brevetoxin uptake and elimination were examined in Eastern oyster (Crassostrea virginica) exposed to recurring blooms of the marine alga Karenia brevis in Sarasota Bay, FL, over a three-year period. Brevetoxins were monitored by in vitro assays (ELISA, cytotoxicity assay, and receptor binding assay) and LC-MS, with in vivo toxicity of shellfish extracts assessed by the traditional mouse bioassay. Measurements by all methods reflected well the progression and magnitude of the blooms. Highest levels recorded by mouse bioassay at bloom peak were 157MU/100g. Oysters were toxic by mouse bioassay at levels >=20MU/100g for up to two weeks after bloom dissipation, whereas brevetoxins were measurable by in vitro assays and LC-MS for several months afterwards. For the structure-based methods, summed values for the principal brevetoxin metabolites of PbTx-2 (cysteine and cysteine sulfoxide conjugates), as determined by LC-MS, were highly correlated (r super(2)=0.90) with composite toxin measurements by ELISA. ELISA and LC-MS values also correlated well (r super(2)=0.74 and 0.73, respectively) with those of mouse bioassay. Pharmacology-based cytotoxicity and receptor binding assays did not correlate as well (r super(2)=0.65), and were weakly correlated with mouse bioassay (r super(2)=0.48 and 0.50, respectively). ELISA and LC-MS methods offer rapid screening and confirmation, respectively, of brevetoxin contamination in the oyster, and are excellent alternatives to mouse bioassay for assessing oyster toxicity following K. brevis blooms. JF - Toxicon AU - Plakas, S M AU - Jester, ELE AU - El Said, KR AU - Granade, H R AU - Abraham, A AU - Dickey, R W AU - Scott, P S AU - Flewelling, L J AU - Henry, M AU - Blum, P AU - Pierce, R AD - U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA, steven.plakas@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 32 EP - 38 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 52 IS - 1 SN - 0041-0101, 0041-0101 KW - Eastern oyster KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Marine KW - Algal blooms KW - ASW, USA, Florida, Sarasota Bay KW - Enzyme-linked immunosorbent assay KW - Contamination KW - Biological poisons KW - Phytoplankton KW - Animal physiology KW - Metabolites KW - Toxicity KW - Toxins KW - Cytotoxicity KW - Bioassays KW - Interspecific relationships KW - Brevetoxins KW - Cysteine KW - Marine molluscs KW - Crassostrea virginica KW - Karenia brevis KW - Q1 08483:Species interactions: general KW - K 03410:Animal Diseases KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24370:Natural Toxins KW - Q5 08504:Effects on organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19480443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Monitoring+of+brevetoxins+in+the+Karenia+brevis+bloom-exposed+Eastern+oyster+%28Crassostrea+virginica%29&rft.au=Plakas%2C+S+M%3BJester%2C+ELE%3BEl+Said%2C+KR%3BGranade%2C+H+R%3BAbraham%2C+A%3BDickey%2C+R+W%3BScott%2C+P+S%3BFlewelling%2C+L+J%3BHenry%2C+M%3BBlum%2C+P%3BPierce%2C+R&rft.aulast=Plakas&rft.aufirst=S&rft.date=2008-07-01&rft.volume=52&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.04.174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Algal blooms; Bioassays; Interspecific relationships; Biological poisons; Phytoplankton; Marine molluscs; Metabolites; Animal physiology; Cytotoxicity; Enzyme-linked immunosorbent assay; Contamination; Cysteine; Brevetoxins; Toxicity; Toxins; Karenia brevis; Crassostrea virginica; ASW, USA, Florida, Sarasota Bay; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2008.04.174 ER - TY - JOUR T1 - Advancing Personalized Health Care through Health Information Technology: An Update from the American Health Information Community's Personalized Health Care Workgroup AN - 19477058; 8339765 AB - The Personalized Health Care Workgroup of the American Health Information Community was formed to determine what is needed to promote standard reporting and incorporation of medical genetic/genomic tests and family health history data in electronic health records. The Workgroup has examined and clarified a range of issues related to this information, including interoperability standards and requirements for confidentiality, privacy, and security, in the course of developing recommendations to facilitate its capture, storage, transmission, and use in clinical decision support. The Workgroup is one of several appointed by the American Health Information Community to study high-priority issues related to the implementation of interoperable electronic health records in the United States. It is also a component of the U.S. Department of Health and Human Services' Personalized Health Care Initiative, which is designed to create a foundation upon which information technology that supports personalized, predictive, and pre-emptive health care can be built. JF - Journal of the American Medical Informatics Association AU - Glaser, John AU - Henley, Douglas E AU - Downing, Gregory AU - Brinner, Kristin M AD - Partners HealthCare, Boston, MA. American Academy of Family Physicians, Leawood, KS. Personalized Health Care Initiative, United States Department of Health and Human Services, Washington, DC. Personalized Health Care Workgroup, American Health Information Community, United States Department of Health and Human Services, Washington, DC Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 391 EP - 396 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 4 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Advancing+Personalized+Health+Care+through+Health+Information+Technology%3A+An+Update+from+the+American+Health+Information+Community%27s+Personalized+Health+Care+Workgroup&rft.au=Glaser%2C+John%3BHenley%2C+Douglas+E%3BDowning%2C+Gregory%3BBrinner%2C+Kristin+M&rft.aulast=Glaser&rft.aufirst=John&rft.date=2008-07-01&rft.volume=15&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - genomics ER - TY - JOUR T1 - Radiation dose reconstruction program of the National Institute for Occupational Safety and Health: Overview AN - 19381807; 8552906 AB - Over the past 65 years, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy or its predecessor agencies. To date, almost 27,000 such employees (or their survivors) have filed claims under Part B of the Energy Employees Occupational Illness Compensation Program Act of 2000, which provides monetary compensation and medical benefits to energy employees who have developed certain types of cancer that have been determined, under the guidelines of the program, to have resulted from occupational radiation exposure covered under the Act. Although it is difficult to predict the number of cancer claims that will be evaluated under this program, the number could double or triple. In each case, the processing of a claim requires that the National Institute for Occupational Safety and Health reconstruct the radiation dose received by the employee followed by a determination by the U.S. Department of Labor as to whether the employee was "at least as likely as not" to have sustained the cancer as a result of his or her occupational exposure to ionizing radiation. Although some of the dose assessments are straightforward, many are extremely complex due to (1) missing, non-interpretable, or undocumented records; (2) a wide variety of external and internal exposure conditions; and/or (3) highly variable work assignments and work loads. The program objectives are to process claims in an effective, efficient, and timely manner. One of the initial challenges was to develop the necessary infrastructure to meet these objectives. Subsequent challenges included documenting that assessments are fair and scientifically consistent. Ensuring that each claimant receives the "benefit of the doubt" in any cases where the required background information and data are ambiguous or not available is also an important objective. Fortunately, there are some aspects of the processing requirements that have tended to reduce the complexity, two examples being that compensation is based on exposures that occurred during covered employment after a cancer has developed and that the required dose estimates are for individual body organs, not effective doses. Throughout the process, every effort has been made to ensure that the dose assessments have the support of the best available science. JF - Health Physics AU - Neton, J W AU - Howard, J AU - Elliott, L J AD - CDC/NIOSH/OD, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA, jfn2@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 6 EP - 13 VL - 95 IS - 1 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - employment KW - Data processing KW - Occupational safety KW - Organs KW - Cancer KW - USA KW - guidelines KW - Energy KW - Reviews KW - Ionizing radiation KW - Economics KW - infrastructure KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19381807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Radiation+dose+reconstruction+program+of+the+National+Institute+for+Occupational+Safety+and+Health%3A+Overview&rft.au=Neton%2C+J+W%3BHoward%2C+J%3BElliott%2C+L+J&rft.aulast=Neton&rft.aufirst=J&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Ionizing radiation; Reviews; Energy; Occupational exposure; Cancer; employment; guidelines; Economics; Occupational safety; infrastructure; Organs; USA ER - TY - JOUR T1 - Establishing bounding internal dose estimates for thorium activities at Rocky Flats AN - 19380561; 8552913 AB - As part of an evaluation of a Special Exposure Cohort petition filed on behalf of workers at the Rocky Flats Plant, the National Institute for Occupational Safety and Health (NIOSH) was required to demonstrate that bounding values could be established for radiation doses due to the potential intake of all radionuclides present at the facility. The main radioactive elements of interest at Rocky Flats were plutonium and uranium, but much smaller quantities of several other elements, including thorium, were occasionally handled at the site. Bounding potential doses from thorium has proven challenging at other sites due to the early historical difficulty in detecting this element through urinalysis methods and the relatively high internal dose delivered per unit intake. This paper reports the results of NIOSH's investigation of the uses of thorium at Rocky Flats and provides bounding dose reconstructions for these operations. During this investigation, NIOSH reviewed unclassified reports, unclassified extracts of classified materials, material balance and inventory ledgers, monthly progress reports from various groups, and health physics field logbooks, and conducted interviews with former Rocky Flats workers. Thorium operations included: (1) an experimental metal forming project with 240 kg of thorium in 1960; (2) the use of pre-formed parts in weapons mockups; (3) the removal of super(228)Th from super(233)U; (4) numerous analytical procedures involving trace quantities of thorium; and (5) the possible experimental use of thorium as a mold coating compound. The thorium handling operations at Rocky Flats were limited in scope, well-monitored and documented, and potential doses can be bounded. JF - Health Physics AU - Ulsh, BA AU - Rich, B L AU - Chew, M H AU - Morris, R L AU - Sharfi, M AU - Rolfes, M R AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop C-46, Cincinnati, OH 45226, USA, bau6@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 81 EP - 88 VL - 95 IS - 1 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Historical account KW - Metals KW - Plutonium KW - Radioisotopes KW - Occupational safety KW - Uranium KW - Occupational exposure KW - Thorium KW - material balance KW - Weapons KW - Reviews KW - Coatings UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19380561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Establishing+bounding+internal+dose+estimates+for+thorium+activities+at+Rocky+Flats&rft.au=Ulsh%2C+BA%3BRich%2C+B+L%3BChew%2C+M+H%3BMorris%2C+R+L%3BSharfi%2C+M%3BRolfes%2C+M+R&rft.aulast=Ulsh&rft.aufirst=BA&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Thorium; Occupational exposure; Weapons; material balance; Metals; Uranium; Plutonium; Reviews; Coatings; Occupational safety; Historical account; Radioisotopes ER - TY - CPAPER T1 - Determination of Total Trans Fatty Acids by GC and IR for Regulatory Compliance T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41043959; 4894966 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Mossoba, M Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Compliance KW - Fatty acids KW - Guanylate cyclase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Determination+of+Total+Trans+Fatty+Acids+by+GC+and+IR+for+Regulatory+Compliance&rft.au=Mossoba%2C+M&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trans Fat Labeling and Regulations T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41041303; 4894967 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Moss, J Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Food KW - Fats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41041303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Trans+Fat+Labeling+and+Regulations&rft.au=Moss%2C+J&rft.aulast=Moss&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What is Natural from an FDA Perspective? T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41040745; 4894701 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Nalubola, R Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41040745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=What+is+Natural+from+an+FDA+Perspective%3F&rft.au=Nalubola%2C+R&rft.aulast=Nalubola&rft.aufirst=R&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using a Rapid Multiplex Real-Time PCR Assay for Simultaneous Detection of Salmonella, Shigella and Escherichia coli o157:h7 in potato salad T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41037512; 4894575 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Lin, W AU - Cheng, C AU - Van, K Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Solanum tuberosum KW - Escherichia coli KW - Salmonella KW - Shigella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41037512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Using+a+Rapid+Multiplex+Real-Time+PCR+Assay+for+Simultaneous+Detection+of+Salmonella%2C+Shigella+and+Escherichia+coli+o157%3Ah7+in+potato+salad&rft.au=Lin%2C+W%3BCheng%2C+C%3BVan%2C+K&rft.aulast=Lin&rft.aufirst=W&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thermal Stability of Ricin in Orange Juice T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41016129; 4894286 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Jackson, L AU - Tolleson, W H Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Ricin KW - Thermal stability KW - Fruit juices KW - Citrus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41016129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Thermal+Stability+of+Ricin+in+Orange+Juice&rft.au=Jackson%2C+L%3BTolleson%2C+W+H&rft.aulast=Jackson&rft.aufirst=L&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Perspective and Guidelines or Regulations for Minimally Processed Foods T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41015960; 4894934 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Skinner, J AU - Larkin, G Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Guidelines KW - FDA KW - Food processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41015960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=FDA+Perspective+and+Guidelines+or+Regulations+for+Minimally+Processed+Foods&rft.au=Skinner%2C+J%3BLarkin%2C+G&rft.aulast=Skinner&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current FDA Retail Food Safety Activities and Future Trends T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41015309; 4894843 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Bohm, S Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Food contamination KW - FDA KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41015309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Current+FDA+Retail+Food+Safety+Activities+and+Future+Trends&rft.au=Bohm%2C+S&rft.aulast=Bohm&rft.aufirst=S&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Method for Determination of Epichlorohydrin (ECH) in Food Contact Materials by Oxolane Derivatization and Gas Chromatography-Mass Spectrometry (GC-MS) T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41014952; 4894004 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Sung, J AU - Yoon, H AU - Lee, Y Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Spectrometry KW - Epichlorohydrin KW - Mass spectroscopy KW - Gas chromatography KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41014952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=New+Method+for+Determination+of+Epichlorohydrin+%28ECH%29+in+Food+Contact+Materials+by+Oxolane+Derivatization+and+Gas+Chromatography-Mass+Spectrometry+%28GC-MS%29&rft.au=Sung%2C+J%3BYoon%2C+H%3BLee%2C+Y&rft.aulast=Sung&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Produce Safety: What We Know, What We Need to Know and How to Get there T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41011948; 4894762 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Smith, M A Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41011948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Produce+Safety%3A+What+We+Know%2C+What+We+Need+to+Know+and+How+to+Get+there&rft.au=Smith%2C+M+A&rft.aulast=Smith&rft.aufirst=M&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry. AN - 69225540; 18494486 AB - Pet and food animal (hogs, chicken, and fish) feeds were recently found to be contaminated with melamine (MEL). A quantitative and confirmatory method is presented to determine MEL residues in edible tissues from fish fed this contaminant. Edible tissues were extracted with acidic acetonitrile, defatted with dichloromethane, and cleaned up using mixed-mode cation exchange solid-phase extraction cartridges. Extracts were analyzed by liquid chromatography with tandem mass spectrometry with hydrophilic interaction chromatography and electrospray ionization in positive ion mode. Fish and shrimp tissues were fortified with 10-500 microg/kg (ppb) of MEL with an average recovery of 63.8% (21.5% relative standard deviation, n = 121). Incurred fish tissues were generated by feeding fish up to 400 mg/kg of MEL or a combination of MEL and the related triazine cyanuric acid (CYA). MEL and CYA are known to form an insoluble complex in the kidneys, which may lead to renal failure. Fifty-five treated catfish, trout, tilapia, and salmon were analyzed after withdrawal times of 1-14 days. MEL residues were found in edible tissues from all of the fish with concentrations ranging from 0.011 to 210 mg/kg (ppm). Incurred shrimp and a survey of market seafood products were also analyzed as part of this study. JF - Journal of agricultural and food chemistry AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Karbiwnyk, Christine M AU - Clark, Susan B AU - Madson, Mark R AU - Gieseker, Charles M AU - Miller, Ron A AU - Rummel, Nathan G AU - Reimschuessel, Renate AD - Animal Drugs Research Center and Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087, USA. Y1 - 2008/06/25/ PY - 2008 DA - 2008 Jun 25 SP - 4340 EP - 4347 VL - 56 IS - 12 KW - Triazines KW - 0 KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Salmon KW - Shellfish -- analysis KW - Animals KW - Ictaluridae KW - Trout KW - Fishes KW - Animal Feed -- analysis KW - Tilapia KW - Triazines -- analysis KW - Food Contamination -- analysis KW - Chromatography, Liquid KW - Seafood -- analysis KW - Tandem Mass Spectrometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69225540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+and+confirmation+of+melamine+residues+in+catfish%2C+trout%2C+tilapia%2C+salmon%2C+and+shrimp+by+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Andersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BKarbiwnyk%2C+Christine+M%3BClark%2C+Susan+B%3BMadson%2C+Mark+R%3BGieseker%2C+Charles+M%3BMiller%2C+Ron+A%3BRummel%2C+Nathan+G%3BReimschuessel%2C+Renate&rft.aulast=Andersen&rft.aufirst=Wendy&rft.date=2008-06-25&rft.volume=56&rft.issue=12&rft.spage=4340&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf800295z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf800295z ER - TY - CPAPER T1 - Gas-Phase Chemistry of Fragrance Compounds T2 - 101st Annual Conference and Exhibition of the Air and Waste Management Association AN - 41043251; 4907804 JF - 101st Annual Conference and Exhibition of the Air and Waste Management Association AU - Forester, C AU - Ham, J AU - Wells, J Y1 - 2008/06/24/ PY - 2008 DA - 2008 Jun 24 KW - Fragrance compounds KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Conference+and+Exhibition+of+the+Air+and+Waste+Management+Association&rft.atitle=Gas-Phase+Chemistry+of+Fragrance+Compounds&rft.au=Forester%2C+C%3BHam%2C+J%3BWells%2C+J&rft.aulast=Forester&rft.aufirst=C&rft.date=2008-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Conference+and+Exhibition+of+the+Air+and+Waste+Management+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={EDF17668- D85D-4ADF-BB4B-795DC0621B8B}&AKey={B2B3355E-B6DC-4154-ABE7-63E874668 9A8} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - BOOK T1 - Child Welfare Policy Manual AN - 61947547; ED501832 AB - This document conveys mandatory policies that have their basis in Federal Law and/or program regulations. It also provides interpretations of Federal Statutes and program regulations initiated by inquiries from State Child Welfare agencies or Administration for Children and Families (ACF) Regional Offices. The manual replaces the Children's Bureau's former policy issuance system, updating and reformatting all of the existing relevant policy issuance's (Policy Announcements and Policy Interpretation Questions) into question and answer format. This manual is broken down into nine main policy areas (with detailed subsections): (1) AFCARS [Adoption and Foster Care Analysis and Reporting System]; (2) CAPTA [Child Abuse Prevention and Treatment Act]; (3) Independent Living; (4) MEPA [Multiethnic Placement Act]/IEAP [Interethnic Adoption Provisions (Small Business Job Protection Act)]; (5) Monitoring; (6) SACWIS [Statewide Automated Child Welfare Information System]; (7) Title IV-B; (8) Title IV-E; and (9) Tribes/Indian Tribal Organizations. Y1 - 2008/06/19/ PY - 2008 DA - 2008 Jun 19 SP - 442 PB - Administration for Children & Families. U.S. Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Information Systems KW - Guidelines KW - Independent Living KW - Program Costs KW - Welfare Services KW - Adoption KW - Public Policy KW - Racial Differences KW - Foster Care KW - Child Welfare KW - Eligibility KW - Tribes KW - Prevention KW - Federal Legislation KW - Federal Regulation KW - Data Collection KW - Compliance (Legal) KW - Guides KW - Policy Analysis KW - Child Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947547?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. AN - 69307632; 18549499 AB - The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals within the control arm of toxicogenomics studies could yield useful information on baseline fluctuations in gene expression, although control animal data has not been available on a scale and in a form best served for data-mining. A dataset of control animal microarray expression data was assembled by a working group of the Health and Environmental Sciences Institute's Technical Committee on the Application of Genomics in Mechanism Based Risk Assessment in order to provide a public resource for assessments of variability in baseline gene expression. Data from over 500 Affymetrix microarrays from control rat liver and kidney were collected from 16 different institutions. Thirty-five biological and technical factors were obtained for each animal, describing a wide range of study characteristics, and a subset were evaluated in detail for their contribution to total variability using multivariate statistical and graphical techniques. The study factors that emerged as key sources of variability included gender, organ section, strain, and fasting state. These and other study factors were identified as key descriptors that should be included in the minimal information about a toxicogenomics study needed for interpretation of results by an independent source. Genes that are the most and least variable, gender-selective, or altered by fasting were also identified and functionally categorized. Better characterization of gene expression variability in control animals will aid in the design of toxicogenomics studies and in the interpretation of their results. JF - BMC genomics AU - Boedigheimer, Michael J AU - Wolfinger, Russell D AU - Bass, Michael B AU - Bushel, Pierre R AU - Chou, Jeff W AU - Cooper, Matthew AU - Corton, J Christopher AU - Fostel, Jennifer AU - Hester, Susan AU - Lee, Janice S AU - Liu, Fenglong AU - Liu, Jie AU - Qian, Hui-Rong AU - Quackenbush, John AU - Pettit, Syril AU - Thompson, Karol L AD - CDER, US FDA, Silver Spring, MD 20993, USA . mboedigh@amgen.com Y1 - 2008/06/12/ PY - 2008 DA - 2008 Jun 12 SP - 285 VL - 9 KW - Index Medicus KW - Animals KW - Reference Values KW - Discriminant Analysis KW - Kidney -- metabolism KW - Sex Characteristics KW - Principal Component Analysis KW - Liver -- metabolism KW - Computational Biology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Fasting -- metabolism KW - Multivariate Analysis KW - Rats KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Databases, Nucleic Acid KW - Rats, Wistar KW - Female KW - Male KW - Genetic Variation KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis -- statistics & numerical data KW - Toxicogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69307632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Sources+of+variation+in+baseline+gene+expression+levels+from+toxicogenomics+study+control+animals+across+multiple+laboratories.&rft.au=Boedigheimer%2C+Michael+J%3BWolfinger%2C+Russell+D%3BBass%2C+Michael+B%3BBushel%2C+Pierre+R%3BChou%2C+Jeff+W%3BCooper%2C+Matthew%3BCorton%2C+J+Christopher%3BFostel%2C+Jennifer%3BHester%2C+Susan%3BLee%2C+Janice+S%3BLiu%2C+Fenglong%3BLiu%2C+Jie%3BQian%2C+Hui-Rong%3BQuackenbush%2C+John%3BPettit%2C+Syril%3BThompson%2C+Karol+L&rft.aulast=Boedigheimer&rft.aufirst=Michael&rft.date=2008-06-12&rft.volume=9&rft.issue=&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2F1471-2164-9-285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6 [11134512] BMC Bioinformatics. 2007;8:427 [17980031] Pharmacogenetics. 2002 Jan;12(1):55-65 [11773865] Genome Res. 2002 Feb;12(2):292-7 [11827948] Toxicol Pathol. 2002 Jan-Feb;30(1):80-7 [11890480] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1896-901 [12578971] Genome Biol. 2003;4(5):P3 [12734009] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Mol Endocrinol. 2004 Mar;18(3):747-60 [14684848] Endocrinology. 2004 Apr;145(4):1972-9 [14684613] Environ Health Perspect. 2004 Mar;112(4):417-9 [15033589] Environ Health Perspect. 2004 Mar;112(4):428-38 [15033592] Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599] Physiol Genomics. 2004 Apr 13;17(2):230-44 [14762175] Genomics. 2004 Jun;83(6):980-8 [15177552] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D553-5 [15608260] Toxicol Pathol. 2005;33(1):102-10 [15805061] Toxicol Pathol. 2005;33(1):136-45 [15805065] BMC Physiol. 2005;5(1):8 [15953391] Gene. 2005 Aug 15;356:39-48 [15967596] Life Sci. 2006 May 8;78(24):2787-96 [16360708] Toxicol Sci. 2006 Nov;94(1):226-33 [16917072] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Xenobiotica. 2006 Oct-Nov;36(10-11):938-62 [17118915] J Toxicol Sci. 2006 Dec;31(5):449-69 [17202760] Toxicology. 2001 Mar 7;160(1-3):87-96 [11246128] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2164-9-285 ER - TY - JOUR T1 - Effects of Sampling Artifacts on Occupational Samples of Diesel Particulate Matter AN - 754540829; 13265919 AB - Total carbon (TC) is sometimes used to measure or characterize diesel particulate matter (DPM) in occupational settings such as underground mines. DPM samples are collected on quartz fiber filters. When using quartz fiber filters, adsorption of gas phase organic carbon (OC) has been reported, causing a positive bias in the particulate TC results (adsorption artifact). Most of the data on the sampling artifacts and corrections apply to environmental air sampling, where samples are collected at a much higher filter face velocity and the OC concentrations are generally much lower relative to occupational sampling. In this study, we investigated the effects of adsorption artifact on samples from occupational settings. Samples were collected with and without denuders to determine the amount of gas phase OC collected and the accuracy of certain corrections. In underground stone mines, the adsorption artifact was found to positively bias the particulate TC by greater than 20% for filter loadings below 25 kg/cm2 TC (8-h time weighted average = 262 kg/m3). The tandem filter correction reduced the effect of the artifact, as high as 60% of the TC value, to less than 11% for laboratory data. It also significantly reduced the effect of the artifact obtained for field samples. JF - Environmental Science & Technology AU - Noll, James AU - Birch, M Eileen AD - Pittsburgh Research Laboratory, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236, and Division of Applied Research and Technology, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226 Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 SP - 5223 EP - 5228 PB - American Chemical Society, 1155 16th St., NW Washington DC 20036 USA VL - 42 IS - 14 SN - 0013-936X, 0013-936X KW - Pollution Abstracts; Environment Abstracts KW - Filters KW - Carbon KW - Organic carbon KW - Adsorption KW - Air sampling KW - Velocity KW - Particulates KW - Mines KW - artifacts KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754540829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Effects+of+Sampling+Artifacts+on+Occupational+Samples+of+Diesel+Particulate+Matter&rft.au=Noll%2C+James%3BBirch%2C+M+Eileen&rft.aulast=Noll&rft.aufirst=James&rft.date=2008-06-10&rft.volume=42&rft.issue=14&rft.spage=5223&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes702883k L2 - http://pubs.acs.org/doi/abs/10.1021/es702883k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Filters; Carbon; Organic carbon; Air sampling; Adsorption; Velocity; Particulates; Mines; artifacts DO - http://dx.doi.org/10.1021/es702883k ER - TY - CPAPER T1 - Occupational Monitoring of Carbonaceous Nanomaterials T2 - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AN - 41073750; 4916438 JF - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AU - Ruda- Eberenz, Toni AU - Birch, M Eileen AU - Evans, Douglas E AU - Ku, Bon-Ki Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41073750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.atitle=Occupational+Monitoring+of+Carbonaceous+Nanomaterials&rft.au=Ruda-+Eberenz%2C+Toni%3BBirch%2C+M+Eileen%3BEvans%2C+Douglas+E%3BKu%2C+Bon-Ki&rft.aulast=Ruda-+Eberenz&rft.aufirst=Toni&rft.date=2008-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2008.org/site/ProgramBook-Final3.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Considerations for Whole Parasite Based Malaria Vaccines T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40964257; 4871273 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Kumar, Sanjai Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Parasites KW - Vaccines KW - Malaria KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=Considerations+for+Whole+Parasite+Based+Malaria+Vaccines&rft.au=Kumar%2C+Sanjai&rft.aulast=Kumar&rft.aufirst=Sanjai&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Continuing reassessment of the risks of erythropoiesis-stimulating agents in patients with cancer. AN - 71629380; 18519748 AB - Erythropoiesis-stimulating agents (ESA) are approved for the treatment of anemia in patients with nonmyeloid malignancies whose anemia is due to the effect of concomitantly administered chemotherapy. Since the 1993 approval of epoetin alfa in patients with cancer, the risk of thrombovascular events, decreased survival, and poorer tumor control have been increasingly recognized. The risks of ESAs in patients with cancer and the design of trials to assess these risks have been the topic of discussion at two Oncologic Drugs Advisory Committees in 2004 and 2007. Evaluation of randomized clinical trials comparing use of ESAs to transfusion support alone in patients with active cancer. Six studies (Breast Cancer Erythropoeitin Survival Trial, Evaluation of NeoRecormon on outcome in Head And Neck Cancer in Europe, Danish Head and Neck Cancer, Lymphoid Malignancy, CAN-20, and Anemia of Cancer) investigating ESAs in oncology patients showed decreased survival, decreased duration of locoregional tumor control, and/or increased risk of thrombovascular events. In these six studies, ESA dosing was targeted to achieve and maintain hemoglobin values in excess of current recommendations, and in three of the six studies, ESAs were administered to patients not receiving chemotherapy. ESAs increase the risk of thrombovascular events and result in decreased survival and poorer tumor control when administered to achieve hemoglobin levels of > or =12 g/dL in patients with nonmyeloid malignancies. No completed or ongoing randomized, controlled trial has addressed safety issues of ESAs in patients with chemotherapy-associated anemia using currently approved dosing regimens in an epidermal tumor type. Additional studies are needed to better characterize these risks. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Juneja, Vinni AU - Keegan, Patricia AU - Gootenberg, Joseph E AU - Rothmann, Mark D AU - Shen, Yuan Li AU - Lee, Kyung Y AU - Weiss, Karen D AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, MD 20993, USA. vinni.juneja@fda.hhs.gov Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 3242 EP - 3247 VL - 14 IS - 11 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Hematinics KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Risk Factors KW - Humans KW - Blood Transfusion KW - Antineoplastic Agents -- adverse effects KW - Neoplasms -- drug therapy KW - Neoplasms -- complications KW - Anemia -- chemically induced KW - Anemia -- drug therapy KW - Hematinics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71629380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Continuing+reassessment+of+the+risks+of+erythropoiesis-stimulating+agents+in+patients+with+cancer.&rft.au=Juneja%2C+Vinni%3BKeegan%2C+Patricia%3BGootenberg%2C+Joseph+E%3BRothmann%2C+Mark+D%3BShen%2C+Yuan+Li%3BLee%2C+Kyung+Y%3BWeiss%2C+Karen+D%3BPazdur%2C+Richard&rft.aulast=Juneja&rft.aufirst=Vinni&rft.date=2008-06-01&rft.volume=14&rft.issue=11&rft.spage=3242&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1872 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-28 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1872 ER - TY - JOUR T1 - New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process. AN - 70785500; 18378963 AB - Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the publication of the US Food and Drug Administration's (FDA's) first in vitro and in vivo drug interaction guidance documents in 1997 and 1999, researchers and clinicians have gained a better understanding of drug interactions. This knowledge has enabled the FDA and the industry to progress and begin to overcome these challenges. The FDA has continued its efforts to evaluate methodologies to study drug interactions and communicate recommendations regarding the conduct of drug interaction studies, particularly for CYP-based and transporter-based drug interactions, to the pharmaceutical industry. A drug interaction Web site was established to document the FDA's current understanding of drug interactions (http://www.fda.gov/cder/drug/drugInteractions/default.htm). This report provides an overview of the evolution of the drug interaction guidances, includes a synopsis of the steps taken by the FDA to revise the original drug interaction guidance documents, and summarizes and highlights updated sections in the current guidance document, Drug Interaction Studies-Study Design, Data Analysis, and Implications for Dosing and Labeling. JF - Journal of clinical pharmacology AU - Huang, Shiew-Mei AU - Strong, John M AU - Zhang, Lei AU - Reynolds, Kellie S AU - Nallani, Srikanth AU - Temple, Robert AU - Abraham, Sophia AU - Habet, Sayed Al AU - Baweja, Raman K AU - Burckart, Gilbert J AU - Chung, Sang AU - Colangelo, Philip AU - Frucht, David AU - Green, Martin D AU - Hepp, Paul AU - Karnaukhova, Elena AU - Ko, Hon-Sum AU - Lee, Jang-Ik AU - Marroum, Patrick J AU - Norden, Janet M AU - Qiu, Wei AU - Rahman, Atiqur AU - Sobel, Solomon AU - Stifano, Toni AU - Thummel, Kenneth AU - Wei, Xiao-Xiong AU - Yasuda, Sally AU - Zheng, Jenny H AU - Zhao, Hong AU - Lesko, Lawrence J AD - Office of Clinical Pharmacology, CDER, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 662 EP - 670 VL - 48 IS - 6 SN - 0091-2700, 0091-2700 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- drug effects KW - Biological Transport -- drug effects KW - Drug Interactions KW - Guidelines as Topic KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=New+era+in+drug+interaction+evaluation%3A+US+Food+and+Drug+Administration+update+on+CYP+enzymes%2C+transporters%2C+and+the+guidance+process.&rft.au=Huang%2C+Shiew-Mei%3BStrong%2C+John+M%3BZhang%2C+Lei%3BReynolds%2C+Kellie+S%3BNallani%2C+Srikanth%3BTemple%2C+Robert%3BAbraham%2C+Sophia%3BHabet%2C+Sayed+Al%3BBaweja%2C+Raman+K%3BBurckart%2C+Gilbert+J%3BChung%2C+Sang%3BColangelo%2C+Philip%3BFrucht%2C+David%3BGreen%2C+Martin+D%3BHepp%2C+Paul%3BKarnaukhova%2C+Elena%3BKo%2C+Hon-Sum%3BLee%2C+Jang-Ik%3BMarroum%2C+Patrick+J%3BNorden%2C+Janet+M%3BQiu%2C+Wei%3BRahman%2C+Atiqur%3BSobel%2C+Solomon%3BStifano%2C+Toni%3BThummel%2C+Kenneth%3BWei%2C+Xiao-Xiong%3BYasuda%2C+Sally%3BZheng%2C+Jenny+H%3BZhao%2C+Hong%3BLesko%2C+Lawrence+J&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2008-06-01&rft.volume=48&rft.issue=6&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270007312153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Pharmacol. 2009 Mar;49(3):368-9; author reply 370 [19246734] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270007312153 ER - TY - JOUR T1 - Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system. AN - 70760594; 18499593 AB - Advances in pediatric and obstetric surgery have resulted in an increase in the duration and complexity of procedures requiring anesthesia. It has been reported that anesthetic drugs cause widespread and dose-dependent apoptosis in the developing rat brain. The similarity of the physiology, pharmacology, metabolism, and reproductive systems of the nonhuman primate to that of the human, especially during pregnancy, make the monkey an exceptionally good animal model for assessing potential neurotoxic effects of anesthetics. The window of vulnerability to these neuronal effects of pediatric anesthetics is restricted to the period of rapid synaptogenesis, also known as the brain growth spurt period. To minimize the risks to children resulting from the use of anesthesia, the following questions should be addressed: 1. What is the relationship between exposure and brain cell loss for drugs commonly used in the practice of pediatric anesthesia (inhaled anesthetics, midazolam, ketamine, and nitrous oxide)? 2. Are there "class effects," or does each drug need to be considered independently? 3. Are there important interactions among the drugs used as anesthetics contributing to the risk of brain cell death? 4. What is the likely period of human vulnerability? Pharmacogenomic/system biology approaches have great potential for helping to advance the understanding of brain-related biological processes, including neuronal plasticity and neurotoxicity. Because of the complexity and temporal features of how developmental neurotoxicity is manifested, pharmacogenomic/systems biology approaches may prove to be useful tools for enhancing our understanding of the biological processes induced by anesthetics. Therefore, the main purpose of this review is to describe the application of these approaches and models, as well as protection strategies, especially as regards the issue of anesthetic-induced neuronal cell death during development. Much of the discussion that follows is based on experiments conducted with ketamine. This is due in part to the use of ketamine in the early studies and the volume of preclinical experimental work performed with this drug, as well as its use in anesthetic studies in developing rodents and nonhuman primates. Although ketamine use in pediatric anesthesia is relatively limited, the findings of the studies are sufficiently strong to merit concern about the N-methyl-d-aspartate antagonist drugs as a class. Our focus on ketamine should not be construed as implying that the risk of neurodegeneration with ketamine is greater, or less, than with other anesthetics. We are simply describing the effects where we have the most preclinical data. JF - Anesthesia and analgesia AU - Wang, Cheng AU - Slikker, William AD - Division of Neurotoxicology, National Center for Toxicological Research/F3900 NCTR Road, Jefferson, AR 72079-9502, USA. cheng.wang@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1643 EP - 1658 VL - 106 IS - 6 KW - Anesthetics KW - 0 KW - Neuroprotective Agents KW - Ketamine KW - 690G0D6V8H KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Ketamine -- toxicity KW - Synapses -- drug effects KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Death -- drug effects KW - Pharmacogenetics KW - Risk Assessment KW - Neuroprotective Agents -- pharmacology KW - Rats KW - Animals, Newborn KW - Behavior, Animal -- drug effects KW - Systems Biology KW - Macaca mulatta KW - Synapses -- metabolism KW - Species Specificity KW - Drug Evaluation, Preclinical KW - Anesthetics -- toxicity KW - Nervous System -- drug effects KW - Neurotoxicity Syndromes -- etiology KW - Nerve Degeneration -- chemically induced KW - Nerve Degeneration -- prevention & control KW - Nervous System -- pathology KW - Biomedical Research KW - Nerve Degeneration -- metabolism KW - Neurotoxicity Syndromes -- prevention & control KW - Nerve Degeneration -- pathology KW - Nervous System -- metabolism KW - Nervous System -- growth & development KW - Neurotoxicity Syndromes -- metabolism KW - Neurotoxicity Syndromes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70760594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Strategies+and+experimental+models+for+evaluating+anesthetics%3A+effects+on+the+developing+nervous+system.&rft.au=Wang%2C+Cheng%3BSlikker%2C+William&rft.aulast=Wang&rft.aufirst=Cheng&rft.date=2008-06-01&rft.volume=106&rft.issue=6&rft.spage=1643&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/10.1213%2Fane.ob013e3181732c01 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1213/ane.ob013e3181732c01 ER - TY - JOUR T1 - Adjustment for temporal confounders in a reanalysis of a case-control study of beryllium and lung cancer. AN - 70748376; 17890301 AB - To evaluate potential confounding of the association between beryllium and lung cancer in a reanalysis of data from a published case-control study of workers at a beryllium processing facility. The association of cumulative and average beryllium exposure with lung cancer among 142 cases and five age-match controls per case was reanalysed using conditional logistic regression. Adjustment was made independently for potential confounders of hire age and birth year. Alternative adjustments to avoid taking the logarithm of zero were explored. Adjustment for either birth cohort or hire age (two highly correlated factors) attenuated lung cancer risk associated with cumulative exposure; however, lung cancer risk was significantly associated with average exposure using a 10-year lag following adjustment. Stratification of analyses by birth cohort found greater lung cancer risk from cumulative and average exposure for workers born before 1900 than for workers born later. The magnitude of the association between lung cancer and average exposure was not reduced by modifying the method used to take the log of exposure. In this reanalysis, average, but not cumulative, beryllium exposure was related to lung cancer risk after adjustment for birth cohort. Confounding by birth cohort is likely related to differences in smoking patterns for workers born before 1900 and the tendency for workers hired during the World War II era to have been older at hire. JF - Occupational and environmental medicine AU - Schubauer-Berigan, M K AU - Deddens, J A AU - Steenland, K AU - Sanderson, W T AU - Petersen, M R AD - NIOSH, DSHEFS, MS-R15, 4676 Columbia Pkwy, Cincinnati, Ohio 45226, USA. zcg3@cdc.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 379 EP - 383 VL - 65 IS - 6 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Age Factors KW - Aged, 80 and over KW - Humans KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Occupational Exposure -- adverse effects KW - Data Interpretation, Statistical KW - Aged KW - Middle Aged KW - Occupational Exposure -- analysis KW - Male KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70748376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Adjustment+for+temporal+confounders+in+a+reanalysis+of+a+case-control+study+of+beryllium+and+lung+cancer.&rft.au=Schubauer-Berigan%2C+M+K%3BDeddens%2C+J+A%3BSteenland%2C+K%3BSanderson%2C+W+T%3BPetersen%2C+M+R&rft.aulast=Schubauer-Berigan&rft.aufirst=M&rft.date=2008-06-01&rft.volume=65&rft.issue=6&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Occup Environ Med. 2008 Jun;65(6):368-70 [18487425] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Animal studies in the development of medical countermeasures. AN - 70745171; 18323860 AB - The mission of the US Food and Drug Administration (FDA) is to protect public health by ensuring the safety, efficacy, and quality of drugs. In drug development, animal studies play a key role in assessing the safety (toxicology), pharmacokinetics (PK), and proof-of-concept efficacy of a new product. When clinical studies are neither ethical nor feasible to conduct, the Animal Rule (67 FR 37988, 2002) introduces the potential for drug (e.g., countermeasure) approval based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. The Center for Drug Evaluation and Research is responsible for the review of drug and therapeutic biologic applications. The use of the word "drugs" in this paper will henceforth refer to both drugs and therapeutic biologics (e.g., monoclonal antibodies and small protein molecules). Information about vaccines and other biologics, such as antisera and blood products, should be obtained from the Center for Biologic Evaluation and Research. JF - Clinical pharmacology and therapeutics AU - Roberts, R AU - McCune, S K AD - US Food and Drug Administration, Silver Spring, Maryland, USA. rosemary.roberts@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 918 EP - 920 VL - 83 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration -- trends KW - Animals KW - Humans KW - United States Food and Drug Administration -- standards KW - Biomedical Research -- standards KW - Biomedical Research -- trends KW - Biomedical Research -- methods KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70745171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Animal+studies+in+the+development+of+medical+countermeasures.&rft.au=Roberts%2C+R%3BMcCune%2C+S+K&rft.aulast=Roberts&rft.aufirst=R&rft.date=2008-06-01&rft.volume=83&rft.issue=6&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.23 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.23 ER - TY - JOUR T1 - ATSDR evaluation of potential for human exposure to benzene. AN - 69821088; 19022881 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for benzene. The primary purpose of this article is to provide interested individuals with environmental information on benzene that includes production data, environmental fate, potential for human exposure, analytical methods, and a listing of regulations and advisories. JF - Toxicology and industrial health AU - Wilbur, S AU - Wohlers, D AU - Paikoff, S AU - Keith, L S AU - Faroon, O AD - Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA. sdw9@cdc.gov PY - 2008 SP - 399 EP - 442 VL - 24 IS - 5-6 SN - 0748-2337, 0748-2337 KW - Carcinogens, Environmental KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - United States KW - Registries KW - Humans KW - United States Dept. of Health and Human Services KW - Male KW - Female KW - Chemical Industry KW - Risk Assessment KW - Environmental Monitoring KW - Public Health KW - Benzene -- analysis KW - Environmental Exposure -- legislation & jurisprudence KW - Benzene -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Carcinogens, Environmental -- analysis KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69821088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+potential+for+human+exposure+to+benzene.&rft.au=Wilbur%2C+S%3BWohlers%2C+D%3BPaikoff%2C+S%3BKeith%2C+L+S%3BFaroon%2C+O&rft.aulast=Wilbur&rft.aufirst=S&rft.date=2008-06-01&rft.volume=24&rft.issue=5-6&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708095772 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233708095772 ER - TY - JOUR T1 - ATSDR evaluation of health effects of benzene and relevance to public health. AN - 69818234; 19022880 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Benzene. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of benzene. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. JF - Toxicology and industrial health AU - Wilbur, S AU - Wohlers, D AU - Paikoff, S AU - Keith, L S AU - Faroon, O AD - Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA. sdw9@cdc.gov PY - 2008 SP - 263 EP - 398 VL - 24 IS - 5-6 SN - 0748-2337, 0748-2337 KW - Carcinogens, Environmental KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - United States KW - Registries KW - Environmental Monitoring KW - Animals KW - Humans KW - United States Dept. of Health and Human Services KW - Animals, Laboratory KW - Male KW - Female KW - Public Health KW - Benzene -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69818234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+health+effects+of+benzene+and+relevance+to+public+health.&rft.au=Wilbur%2C+S%3BWohlers%2C+D%3BPaikoff%2C+S%3BKeith%2C+L+S%3BFaroon%2C+O&rft.aulast=Wilbur&rft.aufirst=S&rft.date=2008-06-01&rft.volume=24&rft.issue=5-6&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090910 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233708090910 ER - TY - JOUR T1 - Reducing risk on machinery: a field evaluation pilot study of risk assessment. AN - 69338724; 18643827 AB - A pilot evaluation of the ANSI B11-TR3 Machinery Risk Assessment/Risk Reduction (RA/RR) Guideline was conducted. The TR3 guideline was introduced into five companies on one machinery system in each company with a second machine system serving as a control. A pre-post investigation was performed with safety conditions measured pre and post in both treatment and control and with risk reduction score measured only in the treatment machine system. NIOSH provided a commercially available risk assessment software to facilitate the process. Evaluation measures included avoided injuries, reduced exposure to machinery hazards, pretest and posttest knowledge demonstration, assessment of group processes following training, correct implementation of the guidelines, and degree to which risk reduction recommendations were implemented. The qualitative results of this pilot effort appear to be the best indicators for the way ahead in industrial machine risk assessment. All companies indicated that they derived value in participating in this study and in conducting risk assessments. Quantitative study results suggest that: (1) as measured by the knowledge of the participants before and after the TR3 training, the guidelines can be effective at enhancing employee knowledge of safe machine operations and (2) although the injury reduction trends appear successful, the small sample size in the study size should be considered in interpreting these early results. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Etherton, John AU - Main, Bruce AU - Cloutier, Dennis AU - Christensen, Wayne AD - NIOSH, Center for Safer Solutions, Morgantown, WV, USA. jre@saferjobs.com Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 711 EP - 721 VL - 28 IS - 3 KW - Index Medicus KW - United States KW - Software KW - Occupational Health KW - Humans KW - Equipment Safety KW - United States Occupational Safety and Health Administration KW - Pilot Projects KW - Guidelines as Topic KW - Workplace KW - Time Factors KW - Safety Management KW - National Institute for Occupational Safety and Health (U.S.) KW - Risk Assessment KW - Accidents, Occupational -- prevention & control KW - Risk Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69338724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Reducing+risk+on+machinery%3A+a+field+evaluation+pilot+study+of+risk+assessment.&rft.au=Etherton%2C+John%3BMain%2C+Bruce%3BCloutier%2C+Dennis%3BChristensen%2C+Wayne&rft.aulast=Etherton&rft.aufirst=John&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01045.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01045.x ER - TY - JOUR T1 - Role of the U.S. Food and Drug Administration in the regulatory management of human listeriosis in the United States. AN - 69281939; 18592761 AB - From 1986 to 2006, the incidence of listeriosis in the United States dropped from approximately seven to three cases per million population, a reduction that most likely reflects the joint efforts of industry, government, consumers, and academia. Herein, we describe the U.S. Food and Drug Administration (FDA) strategy over the past three decades to combat listeriosis. Specifically, we discuss early actions taken to address outbreaks during the 1980s, policy decisions regarding the presence of Listeria monocytogenes in FDA-regulated foods, FDA compliance programs with L. monocytogenes components, enforcement actions to remove L. monocytogenes-contaminated products from the market (i.e., recalls) or to prevent entry of such products into the market (i.e., import detentions and refusals), research milestones, outreach and education efforts, and selected special projects. Evolving demographic trends in the United States may pose a challenge to further reduction of the incidence of listeriosis. JF - Journal of food protection AU - Klontz, Karl C AU - McCarthy, Patrick V AU - Datta, Atin R AU - Lee, Judy O AU - Acheson, David W K AU - Brackett, Robert E AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA. karl.klontz@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1277 EP - 1286 VL - 71 IS - 6 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Public Health KW - Food Microbiology KW - Consumer Product Safety KW - Disease Outbreaks -- prevention & control KW - Humans KW - United States -- epidemiology KW - Risk Assessment KW - Prevalence KW - Listeriosis -- epidemiology KW - Food Contamination -- prevention & control KW - United States Food and Drug Administration KW - Listeria monocytogenes -- growth & development KW - Listeriosis -- prevention & control KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69281939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Role+of+the+U.S.+Food+and+Drug+Administration+in+the+regulatory+management+of+human+listeriosis+in+the+United+States.&rft.au=Klontz%2C+Karl+C%3BMcCarthy%2C+Patrick+V%3BDatta%2C+Atin+R%3BLee%2C+Judy+O%3BAcheson%2C+David+W+K%3BBrackett%2C+Robert+E&rft.aulast=Klontz&rft.aufirst=Karl&rft.date=2008-06-01&rft.volume=71&rft.issue=6&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-11 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma. AN - 69270580; 18586926 AB - To describe the clinical trials leading to U.S. Food and Drug Administration (FDA) approval of nelarabine (Arranon), a new purine analogue, for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. Two phase II trials, one conducted in pediatric patients and the other in adult patients, were reviewed. Patients were in their first or subsequent relapse and/or were refractory to first-line therapy. The dose and schedule of i.v. nelarabine in the pediatric and adult studies were 650 mg/m2 per day daily for 5 days and 1,500 mg/m2 i.v. on days 1, 3, and 5, respectively. Treatments were repeated every 21 days. Study endpoints were the rates of complete response (CR) and CR with incomplete hematologic or bone marrow recovery (CR*). The pediatric efficacy population consisted of 39 patients who had relapsed after, or had been refractory to, two or more induction regimens. CR to nelarabine treatment was observed in five patients (13%) and CR+CR* was observed in nine patients (23%). The adult efficacy population consisted of 28 patients. CR to nelarabine treatment was observed in five patients (18%) and CR+CR* was observed in six patients (21%). Neurologic toxicity was dose limiting for both pediatric and adult patients. Other severe toxicities included hematologic, hepatic, and metabolic laboratory abnormalities in pediatric patients and gastrointestinal and pulmonary toxicities in adults. On October 28, 2005, the FDA granted accelerated approval for nelarabine for treatment of patients with relapsed or refractory T-ALL/T-LBL after at least two prior regimens. This use is based on the induction of CR. The applicant will conduct postmarketing clinical trials to demonstrate clinical benefit, for example, survival prolongation. JF - The oncologist AU - Cohen, Martin H AU - Johnson, John R AU - Justice, Robert AU - Pazdur, Richard AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA. martin.cohen@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 709 EP - 714 VL - 13 IS - 6 SN - 1083-7159, 1083-7159 KW - Arabinonucleosides KW - 0 KW - nelarabine KW - 60158CV180 KW - Index Medicus KW - United States KW - Infant KW - United States Food and Drug Administration KW - Clinical Trials, Phase II as Topic KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Child, Preschool KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Drug Approval -- legislation & jurisprudence KW - Leukemia-Lymphoma, Adult T-Cell -- drug therapy KW - Arabinonucleosides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69270580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+nelarabine+%28Arranon%29+for+the+treatment+of+T-cell+lymphoblastic+leukemia%2Flymphoma.&rft.au=Cohen%2C+Martin+H%3BJohnson%2C+John+R%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2008-06-01&rft.volume=13&rft.issue=6&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2006-0017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-29 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2006-0017 ER - TY - JOUR T1 - Low-fidelity DNA synthesis by human DNA polymerase theta. AN - 69243707; 18503084 AB - Human DNA polymerase theta (pol or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol may synthesize DNA with low fidelity. Here, we show that when copying undamaged DNA, pol generates single base errors at rates 10- to more than 100-fold higher than for other family A members. Pol adds single nucleotides to homopolymeric runs at particularly high rates, exceeding 1% in certain sequence contexts, and generates single base substitutions at an average rate of 2.4 x 10(-3), comparable to inaccurate family Y human pol kappa (5.8 x 10(-3)) also implicated in TLS. Like pol kappa, pol is processive, implying that it may be tightly regulated to avoid deleterious mutagenesis. Pol also generates certain base substitutions at high rates within sequence contexts similar to those inferred to be copied by pol during SHM of immunoglobulin genes in mice. Thus, pol is an exception among family A polymerases, and its low fidelity is consistent with its proposed roles in TLS and SHM. JF - Nucleic acids research AU - Arana, Mercedes E AU - Seki, Mineaki AU - Wood, Richard D AU - Rogozin, Igor B AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 3847 EP - 3856 VL - 36 IS - 11 KW - Nucleotides KW - 0 KW - DNA KW - 9007-49-2 KW - DNA polymerase theta KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Nucleotides -- metabolism KW - Somatic Hypermutation, Immunoglobulin KW - Humans KW - Mutation KW - Nucleotides -- analysis KW - DNA -- chemistry KW - DNA -- biosynthesis KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69243707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Low-fidelity+DNA+synthesis+by+human+DNA+polymerase+theta.&rft.au=Arana%2C+Mercedes+E%3BSeki%2C+Mineaki%3BWood%2C+Richard+D%3BRogozin%2C+Igor+B%3BKunkel%2C+Thomas+A&rft.aulast=Arana&rft.aufirst=Mercedes&rft.date=2008-06-01&rft.volume=36&rft.issue=11&rft.spage=3847&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2006;34(17):4731-42 [16971464] Biochim Biophys Acta. 1992 Nov 15;1171(1):11-8 [1420357] DNA Repair (Amst). 2007 Feb 4;6(2):213-23 [17118716] J Biol Chem. 2007 Jun 15;282(24):17387-94 [17449470] J Biol Chem. 1997 Jan 24;272(4):2559-69 [8999973] J Biol Chem. 1997 Aug 8;272(32):20205-12 [9242698] J Mol Biol. 1999 Jun 18;289(4):835-50 [10369765] Genomics. 1999 Jul 1;59(1):90-6 [10395804] EMBO J. 2004 Nov 10;23(22):4484-94 [15496986] Mol Cell Biol. 2004 Dec;24(23):10381-9 [15542845] Adv Protein Chem. 2004;69:137-65 [15588842] J Exp Med. 2005 Apr 18;201(8):1191-6 [15824086] J Immunol. 2005 Jun 15;174(12):7781-6 [15944281] Annu Rev Biochem. 2005;74:317-53 [15952890] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] J Biol Chem. 2005 Jun 24;280(25):23446-50 [15879599] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91 [16172387] J Biol Chem. 1993 May 15;268(14):10312-23 [7683674] J Biol Chem. 1993 May 15;268(14):10324-34 [7683675] J Biol Chem. 1993 Jun 25;268(18):13462-71 [8390464] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6830-4 [8041704] Methods Enzymol. 1995;262:217-32 [8594349] EMBO J. 2005 Nov 2;24(21):3757-69 [16222339] Cell. 2006 Jan 27;124(2):331-42 [16439207] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] J Biol Chem. 2006 May 19;281(20):13869-72 [16571727] Front Biosci. 2006;11:2496-517 [16720328] Nat Cell Biol. 2006 Jun;8(6):640-2 [16738703] Cell Cycle. 2006 May;5(10):1044-7 [16687932] J Biol Chem. 2006 Aug 18;281(33):23445-55 [16787914] Mol Cell. 2006 Oct 6;24(1):115-25 [17018297] Plant Mol Biol. 2007 Jul;64(5):601-11 [17522954] DNA Repair (Amst). 2008 Jan 1;7(1):119-27 [17920341] Mol Cell. 2007 Dec 14;28(5):702-7 [18082594] Eur J Immunol. 2008 Jan;38(1):227-39 [18081040] Mol Cell. 2007 Dec 28;28(6):1058-70 [18158902] Cell Res. 2008 Jan;18(1):148-61 [18166979] J Biol Chem. 1996 Oct 4;271(40):24954-61 [8798775] J Biol Chem. 1999 Nov 19;274(47):33313-9 [10559208] J Biol Chem. 2000 Dec 15;275(50):39678-84 [11006276] Nat Immunol. 2001 Jun;2(6):530-6 [11376340] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Cell. 2001 Oct 5;107(1):91-102 [11595188] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] J Mol Biol. 2002 May 31;319(2):359-69 [12051913] Genetics. 2003 Mar;163(3):1031-40 [12663541] J Biol Chem. 2003 Aug 22;278(34):32014-9 [12794064] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] Nucleic Acids Res. 2003 Nov 1;31(21):6117-26 [14576298] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Int J Cancer. 2004 Mar10;109(1):9-16 [14735462] J Exp Med. 2004 Jan 19;199(2):265-70 [14734526] J Exp Med. 2004 Apr 5;199(7):917-24 [15051760] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] Biochim Biophys Acta. 1988 Nov 10;951(1):1-15 [2847793] Nucleic Acids Res. 1990 Jul 11;18(13):3739-44 [2374708] J Biol Chem. 1990 Aug 15;265(23):13878-87 [2199444] DNA Repair (Amst). 2006 Nov 8;5(11):1384-91 [16890500] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn310 ER - TY - JOUR T1 - Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin. AN - 69231212; 18566228 AB - We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ralpha2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts, and other cells, and a chimeric fusion protein composed of human IL-13 and mutated Pseudomonas exotoxin (IL-13-PE38) is highly and specifically cytotoxic to these cells in vitro and in vivo. To improve the specificity for the target, we isolated specific antibodies against IL-13Ralpha2 from human single-chain Fv (scFv) antibody phage library and developed immunotoxin by selecting two high-affinity clones of scFv and fused to PE. The fusion chimeric gene was expressed in Escherichia coli, and highly purified IL-13R-specific immunotoxin, termed anti-IL-13Ralpha2(scFv)-PE38, was tested for its cytotoxicity. This molecule was highly cytotoxic to U251 glioma and PM-RCC renal cell carcinoma cell lines in vitro. The cytotoxic activity was neutralized by purified extracellular domain of IL-13Ralpha2 but not by IL-13, indicating that cytotoxic activity is specific. Anti-IL-13Ralpha2(scFv)-PE38 showed significant antitumor activity in immunodeficient mice with s.c. glioma tumors. Both i.p. and i.t. routes of administration showed antitumor activity in a dose-dependent manner. The maximum tolerated dose of anti-IL-13Ralpha2(scFv)-PE38 was 200 microg/kg i.p. twice daily for 5 days. These results indicate that anti-IL-13Ralpha2(scFv)-PE38 is a highly selective therapeutic agent for cancer therapy and should be further tested in animal models of human cancer. JF - Molecular cancer therapeutics AU - Kioi, Mitomu AU - Seetharam, Saraswathy AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, Room 2NN20, 29 Lincoln Drive, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1579 EP - 1587 VL - 7 IS - 6 SN - 1535-7163, 1535-7163 KW - Antibodies KW - 0 KW - Antineoplastic Agents KW - Exotoxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Recombinant Fusion Proteins KW - Index Medicus KW - Clone Cells KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - Recombinant Fusion Proteins -- isolation & purification KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Cell Death -- drug effects KW - Recombinant Fusion Proteins -- metabolism KW - Glioblastoma -- metabolism KW - Xenograft Model Antitumor Assays KW - Protein Structure, Tertiary KW - Antineoplastic Agents -- pharmacology KW - Interleukin-13 Receptor alpha2 Subunit -- metabolism KW - Exotoxins -- pharmacology KW - Antibodies -- pharmacology KW - Mutation -- genetics KW - Immunotoxins -- isolation & purification KW - Interleukin-13 Receptor alpha2 Subunit -- chemistry KW - Immunotoxins -- pharmacology KW - Pseudomonas -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69231212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Targeting+IL-13Ralpha2-positive+cancer+with+a+novel+recombinant+immunotoxin+composed+of+a+single-chain+antibody+and+mutated+Pseudomonas+exotoxin.&rft.au=Kioi%2C+Mitomu%3BSeetharam%2C+Saraswathy%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2008-06-01&rft.volume=7&rft.issue=6&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-07-2131 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-22 N1 - Date created - 2008-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-07-2131 ER - TY - JOUR T1 - Engineering case reports. Effectiveness of local exhaust ventilation (LEV) in controlling engineered nanomaterial emissions during reactor cleanout operations. AN - 69129486; 18432476 JF - Journal of occupational and environmental hygiene AU - Methner, Mark M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - D63 EP - D69 VL - 5 IS - 6 KW - Air Pollutants, Occupational KW - 0 KW - Manganese Compounds KW - Oxides KW - Silver Compounds KW - Cobalt KW - 3G0H8C9362 KW - manganese oxide KW - 64J2OA7MH3 KW - disilver oxide KW - 897WUN6G6T KW - cobalt oxide KW - USK772NS56 KW - Index Medicus KW - Environmental Monitoring KW - Occupational Health KW - Microscopy, Electron, Transmission KW - Occupational Exposure -- prevention & control KW - Engineering KW - Humans KW - Occupational Exposure -- analysis KW - Nanostructures -- ultrastructure KW - Ventilation -- methods KW - Oxides -- analysis KW - Air Pollutants, Occupational -- analysis KW - Silver Compounds -- analysis KW - Cobalt -- analysis KW - Nanostructures -- analysis KW - Manganese Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69129486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Engineering+case+reports.+Effectiveness+of+local+exhaust+ventilation+%28LEV%29+in+controlling+engineered+nanomaterial+emissions+during+reactor+cleanout+operations.&rft.au=Methner%2C+Mark+M&rft.aulast=Methner&rft.aufirst=Mark&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=D63&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620802059393 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802059393 ER - TY - JOUR T1 - Assessment of ecological regression in the study of colon, breast, ovary, non-Hodgkin's lymphoma, or prostate cancer and residential UV. AN - 69102272; 18414201 AB - Recent ecological studies have suggested a possible association between exposure to ultraviolet-B (UVB) radiation and reduction in the risk of various cancers; however, ecological studies are known to be subject to bias. The objective of this study was to demonstrate difficulties with the ecological approach. We conducted a multicountry ecological study using cancer incidence rates, residential UV levels, dietary intake, and different sociodemographic variables for 38 locations spanning 33 countries worldwide. The effect of residential UV exposure on cancer incidence was assessed using multiple linear regression models. The results of our multivariate analyses show no indication of an inverse association between residential UV levels and the risk of colon, non-Hodgkin's lymphoma (NHL), ovarian, prostate, or breast cancer in women. For colon cancer and NHL, a significant positive association was calculated. The rates of melanoma, which were used to examine the methods of this study, showed a strong and significant (P<0.01) association with solar radiation. Our results provide no evidence to support previous ecological results that UV exposure may reduce the risk of NHL, colon, breast, ovary, or prostate cancer. The study demonstrates the high sensitivity of ecological studies to adjustments for various confounders, and casts doubts on results of ecological analyses in this field. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Waltz, Paul AU - Chodick, Gabriel AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 279 EP - 286 VL - 17 IS - 3 KW - Index Medicus KW - Ecosystem KW - Regression Analysis KW - Humans KW - Cohort Studies KW - Residence Characteristics KW - Geography KW - Male KW - Female KW - Multivariate Analysis KW - Prostatic Neoplasms -- etiology KW - Ovarian Neoplasms -- etiology KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Colonic Neoplasms -- epidemiology KW - Prostatic Neoplasms -- epidemiology KW - Colonic Neoplasms -- etiology KW - Ultraviolet Rays -- adverse effects KW - Lymphoma, Non-Hodgkin -- etiology KW - Environmental Exposure KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Ovarian Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Assessment+of+ecological+regression+in+the+study+of+colon%2C+breast%2C+ovary%2C+non-Hodgkin%27s+lymphoma%2C+or+prostate+cancer+and+residential+UV.&rft.au=Waltz%2C+Paul%3BChodick%2C+Gabriel&rft.aulast=Waltz&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=17&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e3282b6fd0f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-30 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Eur J Cancer Prev. 2008 Aug;17(4):384 [18562966] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fd0f ER - TY - JOUR T1 - Funneling Child Welfare Consumers into and through the Mental Health System: Assessment, Referral, and Quality Issues AN - 61426655; 200806249 AB - This qualitative study explores how consumers of child welfare services reach nonpsychiatric mental health providers and the perceived quality of these services. It relies on iterative interviews with individuals and groups, as well as on court observations from one metropolitan area. Results suggest that, consistent with theories of street-level bureaucracy, efficiency issues drive mental health service use, as clients are routinely subjected to psychological evaluations and funneled into mental health services as a matter of course. Referral practices are shaped by child welfare professionals' routines, discretion, and desire to meet such system objectives as providing short turnaround times for reports. The results suggest that, despite stakeholders' best intentions, maltreated children are not benefiting from thoughtful processes geared to screen for, assess, and provide targeted treatment for unmet mental health needs. Adapted from the source document. JF - Social Service Review AU - Fedoravicius, Nicole AU - McMillen, J Curtis AU - Rowe, Jill E AU - Kagotho, Njeri AU - Ware, Norma C AD - Center for Mental Health Services Research, Washington University, St. Louis Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 273 EP - 290 PB - University of Chicago Press, IL VL - 82 IS - 2 SN - 0037-7961, 0037-7961 KW - Bureaucracy KW - Efficiency KW - Motivation KW - Mental Health Services KW - Psychological Theories KW - Metropolitan Areas KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61426655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Service+Review&rft.atitle=Funneling+Child+Welfare+Consumers+into+and+through+the+Mental+Health+System%3A+Assessment%2C+Referral%2C+and+Quality+Issues&rft.au=Fedoravicius%2C+Nicole%3BMcMillen%2C+J+Curtis%3BRowe%2C+Jill+E%3BKagotho%2C+Njeri%3BWare%2C+Norma+C&rft.aulast=Fedoravicius&rft.aufirst=Nicole&rft.date=2008-06-01&rft.volume=82&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Social+Service+Review&rft.issn=00377961&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2008-11-06 N1 - Number of references - 23 N1 - Last updated - 2016-09-28 N1 - CODEN - SSRVAW N1 - SubjectsTermNotLitGenreText - Mental Health Services; Psychological Theories; Metropolitan Areas; Efficiency; Bureaucracy; Motivation ER - TY - BOOK T1 - Estimating the Permeation Resistance of Nonporous Barrier Polymers to Sulfur Mustard (HD) and Sarin (GB) Chemical Warfare Agents Using Liquid Simulants AN - 58792288; 2008-218166 AB - The purpose of this document is to report the results of the NIOSH Chemical Warfare Agent (CWA) Simulant Project that had the following goals: 1.) Identify chemicals (simulants) that simulate the permeation of Sarin (GB) and sulfur mustard (HD) through elastomeric barrier materials that are commonly used in respirators. 2.) Develop a convenient and reliable laboratory procedure (test method) that can be used by Personal Protective Equipment (PPE) manufacturers for estimating GB and HD permeation rates through barrier materials using the simulants. PPE manufacturers can use this method to screen and deselect candidate barrier materials during product development testing. Advancements in this research can benefit the first responder community by providing PPE manufacturers with information and testing techniques that will reduce the time and resources needed to engineer products that weigh less, have better permeation resistance, are less cumbersome, and could potentially be less expensive. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2008, 97 pp. AU - Bartram, Philip W AU - Lindsay, Robert S AU - Palya, Frank Jr AU - Rivin, Donald AU - Rodriguez, Axel AU - Shuely, Wendel J Y1 - 2008/06// PY - 2008 DA - June 2008 EP - 97p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Social conditions and policy - Public safety and security KW - International relations - War KW - Military and defense policy - Military planning, strategy, and operations KW - Science and technology policy - Science and science policy and research KW - Laboratories KW - Chemical warfare KW - Safety measures KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58792288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bartram%2C+Philip+W%3BLindsay%2C+Robert+S%3BPalya%2C+Frank+Jr%3BRivin%2C+Donald%3BRodriguez%2C+Axel%3BShuely%2C+Wendel+J&rft.aulast=Bartram&rft.aufirst=Philip&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=97p&rft.isbn=&rft.btitle=Estimating+the+Permeation+Resistance+of+Nonporous+Barrier+Polymers+to+Sulfur+Mustard+%28HD%29+and+Sarin+%28GB%29+Chemical+Warfare+Agents+Using+Liquid+Simulants&rft.title=Estimating+the+Permeation+Resistance+of+Nonporous+Barrier+Polymers+to+Sulfur+Mustard+%28HD%29+and+Sarin+%28GB%29+Chemical+Warfare+Agents+Using+Liquid+Simulants&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-141/pdfs/2008-141.pdf LA - English DB - PAIS Index N1 - Date revised - 2009-01-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-141 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Three-dimensional time-lapse velocity tomography of an underground longwall panel AN - 50649235; 2008-103492 AB - Three-dimensional velocity tomograms were generated to image the stress redistribution around an underground coal longwall panel to produce a better understanding of the mechanisms that lead to ground failure, especially rockbursts. Mining-induced microseismic events provided passive sources for the three-dimensional velocity tomography. Surface-mounted geophones monitored microseismic activity for 18 days. Eighteen tomograms were generated and high-velocity regions correlated with high abutment stresses predicted by numerical modeling. Additionally, the high-velocity regions were observed to redistribute as the longwall face retreated, indicating that velocity tomography may be an appropriate technology for monitoring stress redistribution in underground mines. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Luxbacher, Kray AU - Westman, Erik AU - Swanson, Peter AU - Karfakis, Mario Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 478 EP - 485 PB - Elsevier, Oxford-New York VL - 45 IS - 4 SN - 1365-1609, 1365-1609 KW - tomography KW - mining KW - failures KW - geologic hazards KW - underground mining KW - three-dimensional models KW - site exploration KW - roof control KW - stress KW - mathematical models KW - rock mechanics KW - sedimentary rocks KW - longwall mining KW - rock bursts KW - coal KW - tunnels KW - time-lapse methods KW - velocity KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50649235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Three-dimensional+time-lapse+velocity+tomography+of+an+underground+longwall+panel&rft.au=Luxbacher%2C+Kray%3BWestman%2C+Erik%3BSwanson%2C+Peter%3BKarfakis%2C+Mario&rft.aulast=Luxbacher&rft.aufirst=Kray&rft.date=2008-06-01&rft.volume=45&rft.issue=4&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2007.07.015 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 45 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - coal; failures; geologic hazards; longwall mining; mathematical models; mining; rock bursts; rock mechanics; roof control; sedimentary rocks; site exploration; stress; three-dimensional models; time-lapse methods; tomography; tunnels; underground mining; velocity DO - http://dx.doi.org/10.1016/j.ijrmms.2007.07.015 ER - TY - CPAPER T1 - Heterogeneity of Tn1546 among VanA-type VRE Isolates of Enterococcus faecium T2 - 108th General Meeting of the American Society for Microbiology AN - 41008685; 4883740 JF - 108th General Meeting of the American Society for Microbiology AU - Sung, K AU - Khan, S A AU - Nawaz, M S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Enterococcus faecium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41008685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Heterogeneity+of+Tn1546+among+VanA-type+VRE+Isolates+of+Enterococcus+faecium&rft.au=Sung%2C+K%3BKhan%2C+S+A%3BNawaz%2C+M+S&rft.aulast=Sung&rft.aufirst=K&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Evaluation of CPC+, a New Medium for Isolation and Enumeration of Vibrio vulnificus from U.S. Market Oysters T2 - 108th General Meeting of the American Society for Microbiology AN - 41008136; 4885028 JF - 108th General Meeting of the American Society for Microbiology AU - Krantz, J A AU - Nordstrom, J L AU - Bowers, J C AU - DePaola, A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Oysters KW - Pathogenic bacteria KW - Vibrio vulnificus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41008136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=An+Evaluation+of+CPC%2B%2C+a+New+Medium+for+Isolation+and+Enumeration+of+Vibrio+vulnificus+from+U.S.+Market+Oysters&rft.au=Krantz%2C+J+A%3BNordstrom%2C+J+L%3BBowers%2C+J+C%3BDePaola%2C+A&rft.aulast=Krantz&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biotransformation of Fluoroquinolones by an Escherichia coli Strain Isolated from a Municipal Wastewater Treatment Plant T2 - 108th General Meeting of the American Society for Microbiology AN - 41006295; 4883551 JF - 108th General Meeting of the American Society for Microbiology AU - Jung, C M AU - Heinze, T M AU - Strakosha, R AU - Elkins, C A AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Municipal wastes KW - Wastewater treatment KW - Biotransformation KW - Fluoroquinolones KW - Strains KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41006295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Biotransformation+of+Fluoroquinolones+by+an+Escherichia+coli+Strain+Isolated+from+a+Municipal+Wastewater+Treatment+Plant&rft.au=Jung%2C+C+M%3BHeinze%2C+T+M%3BStrakosha%2C+R%3BElkins%2C+C+A%3BSutherland%2C+J+B&rft.aulast=Jung&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mouse Model to Study the Efficacy of Potential Vaccines Against ETEC Using a Bioluminescent Reporter Strain T2 - 108th General Meeting of the American Society for Microbiology AN - 41005978; 4885422 JF - 108th General Meeting of the American Society for Microbiology AU - Singh, S AU - Stibitz, S AU - Walker, R AU - Kopecko, D J AU - Osorio, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Vaccines KW - Animal models KW - Bioluminescence KW - Disease control KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Mouse+Model+to+Study+the+Efficacy+of+Potential+Vaccines+Against+ETEC+Using+a+Bioluminescent+Reporter+Strain&rft.au=Singh%2C+S%3BStibitz%2C+S%3BWalker%2C+R%3BKopecko%2C+D+J%3BOsorio%2C+M&rft.aulast=Singh&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution and Evolution of the Palatinose (pal) Operon among Strains of Enterobacter sakazakii T2 - 108th General Meeting of the American Society for Microbiology AN - 41005722; 4885716 JF - 108th General Meeting of the American Society for Microbiology AU - Lamm, K A AU - Rameseshan, A AU - Meng, J AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Operons KW - Evolution KW - Strains KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Distribution+and+Evolution+of+the+Palatinose+%28pal%29+Operon+among+Strains+of+Enterobacter+sakazakii&rft.au=Lamm%2C+K+A%3BRameseshan%2C+A%3BMeng%2C+J%3BBrown%2C+E+W&rft.aulast=Lamm&rft.aufirst=K&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improvements to I-SceI-Mediated Allelic Exchange in Bacillus anthracis T2 - 108th General Meeting of the American Society for Microbiology AN - 41005679; 4885316 JF - 108th General Meeting of the American Society for Microbiology AU - Plaut, R D AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Virulence KW - Pathogenic bacteria KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Improvements+to+I-SceI-Mediated+Allelic+Exchange+in+Bacillus+anthracis&rft.au=Plaut%2C+R+D%3BStibitz%2C+S&rft.aulast=Plaut&rft.aufirst=R&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishment and Validation of a Highly Accurate Method for Assessing Gene Content in E. coli Utilizing Microarray Data without the Need for Comparison to a Reference Strain T2 - 108th General Meeting of the American Society for Microbiology AN - 41005601; 4885696 JF - 108th General Meeting of the American Society for Microbiology AU - Jackson, S A AU - Patel, I R AU - Mammel, M K AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Data processing KW - Strains KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Establishment+and+Validation+of+a+Highly+Accurate+Method+for+Assessing+Gene+Content+in+E.+coli+Utilizing+Microarray+Data+without+the+Need+for+Comparison+to+a+Reference+Strain&rft.au=Jackson%2C+S+A%3BPatel%2C+I+R%3BMammel%2C+M+K%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of Sudan Azo Dyes by Lactobacillus acidophilus and Lactobacillus fermentum T2 - 108th General Meeting of the American Society for Microbiology AN - 41004634; 4883559 JF - 108th General Meeting of the American Society for Microbiology AU - Xu, H. AU - Heinze, T M AU - Cerniglia, C E AU - Chen, H Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Sudan KW - Azo dyes KW - Metabolism KW - Lactobacillus acidophilus KW - Lactobacillus fermentum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Metabolism+of+Sudan+Azo+Dyes+by+Lactobacillus+acidophilus+and+Lactobacillus+fermentum&rft.au=Xu%2C+H.%3BHeinze%2C+T+M%3BCerniglia%2C+C+E%3BChen%2C+H&rft.aulast=Xu&rft.aufirst=H.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of Resveratrol with Animal-Associated Bacteria T2 - 108th General Meeting of the American Society for Microbiology AN - 41004599; 4883553 JF - 108th General Meeting of the American Society for Microbiology AU - Jung, C M AU - Heinze, T M AU - Mullis, L B AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Resveratrol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Interaction+of+Resveratrol+with+Animal-Associated+Bacteria&rft.au=Jung%2C+C+M%3BHeinze%2C+T+M%3BMullis%2C+L+B%3BSutherland%2C+J+B&rft.aulast=Jung&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differentiation of the Salmonella Typhimurium Strain Complex Using Six Enzyme Pulsed-Field Gel Electrophoresis and Comparison with Sequence-Based Typing Methods T2 - 108th General Meeting of the American Society for Microbiology AN - 41004383; 4885338 JF - 108th General Meeting of the American Society for Microbiology AU - Keys, C E AU - Trujillo, S AU - Bell, R L AU - Musser, S M AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Electrophoresis KW - Enzymes KW - Typing KW - Differentiation KW - Pulsed-field gel electrophoresis KW - Anadromous species KW - Strains KW - Salmonella typhimurium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Differentiation+of+the+Salmonella+Typhimurium+Strain+Complex+Using+Six+Enzyme+Pulsed-Field+Gel+Electrophoresis+and+Comparison+with+Sequence-Based+Typing+Methods&rft.au=Keys%2C+C+E%3BTrujillo%2C+S%3BBell%2C+R+L%3BMusser%2C+S+M%3BBrown%2C+E+W&rft.aulast=Keys&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Nucleotide Polymorphisms in the Major Multidrug Efflux Pump, AcrB, of Escherichia coli Isolated from Disparate Animal Reservoirs T2 - 108th General Meeting of the American Society for Microbiology AN - 41004216; 4883735 JF - 108th General Meeting of the American Society for Microbiology AU - Mullis, L B AU - Elkins, C A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Reservoirs KW - Pumps KW - Single-nucleotide polymorphism KW - Nucleotides KW - Biopolymorphism KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Single+Nucleotide+Polymorphisms+in+the+Major+Multidrug+Efflux+Pump%2C+AcrB%2C+of+Escherichia+coli+Isolated+from+Disparate+Animal+Reservoirs&rft.au=Mullis%2C+L+B%3BElkins%2C+C+A&rft.aulast=Mullis&rft.aufirst=L&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Multiplex Real-Time PCR Assay for Rapid and Simultaneous Detection of Salmonella, Shigella, and E. coli O157:H7 T2 - 108th General Meeting of the American Society for Microbiology AN - 41003763; 4885013 JF - 108th General Meeting of the American Society for Microbiology AU - Cheng, C-M AU - Lin, W AU - Van, K Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Escherichia coli KW - Salmonella KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41003763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Multiplex+Real-Time+PCR+Assay+for+Rapid+and+Simultaneous+Detection+of+Salmonella%2C+Shigella%2C+and+E.+coli+O157%3AH7&rft.au=Cheng%2C+C-M%3BLin%2C+W%3BVan%2C+K&rft.aulast=Cheng&rft.aufirst=C-M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNP Profiling of E. coli O157:H7 Strains from Recent Foodborne Outbreaks T2 - 108th General Meeting of the American Society for Microbiology AN - 41003518; 4885706 JF - 108th General Meeting of the American Society for Microbiology AU - Mammel, M K AU - Hayford, A E AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Food-borne diseases KW - Single-nucleotide polymorphism KW - Food KW - Profiling KW - Strains KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41003518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=SNP+Profiling+of+E.+coli+O157%3AH7+Strains+from+Recent+Foodborne+Outbreaks&rft.au=Mammel%2C+M+K%3BHayford%2C+A+E%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Mammel&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Methods for Bacterial Gene Identification and Characterization in Microarray Data Analysis T2 - 108th General Meeting of the American Society for Microbiology AN - 41003455; 4885701 JF - 108th General Meeting of the American Society for Microbiology AU - Zou, W AU - Chang, C-W AU - Nayak, R AU - Chen, J J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41003455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=New+Methods+for+Bacterial+Gene+Identification+and+Characterization+in+Microarray+Data+Analysis&rft.au=Zou%2C+W%3BChang%2C+C-W%3BNayak%2C+R%3BChen%2C+J+J&rft.aulast=Zou&rft.aufirst=W&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Investigation of a Seven Gene Multi-Locus Sequence Typing Scheme to Discriminate a Closely Related Collection of Salmonella T2 - 108th General Meeting of the American Society for Microbiology AN - 41001270; 4883630 JF - 108th General Meeting of the American Society for Microbiology AU - Bell, R L AU - Andrzejewski, D AU - Callahan, J H AU - Musser, S M AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Typing KW - Anadromous species KW - Phylogeny KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=An+Investigation+of+a+Seven+Gene+Multi-Locus+Sequence+Typing+Scheme+to+Discriminate+a+Closely+Related+Collection+of+Salmonella&rft.au=Bell%2C+R+L%3BAndrzejewski%2C+D%3BCallahan%2C+J+H%3BMusser%2C+S+M%3BBrown%2C+E+W&rft.aulast=Bell&rft.aufirst=R&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Matrix Type, Enrichment Medium, and Genomic DNA Extraction Method on Real-Time PCR Inhibition and Detection of Yersinia enterocolitica from Environmental Swabs T2 - 108th General Meeting of the American Society for Microbiology AN - 41001222; 4885024 JF - 108th General Meeting of the American Society for Microbiology AU - Stewart, D AU - Laird, D AU - Reineke, K AU - Tortorello, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Genomics KW - Nucleotide sequence KW - Yersinia enterocolitica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Inactivation+of+Clostridium+botulinum+Type+A+Neurotoxin+in+Milk+by+High+Pressure+Processing&rft.au=Schlesser%2C+J+E%3BGerdes%2C+R%3BSkinner%2C+G+E%3BReddy%2C+N+R%3BParisi%2C+B&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization by Optical Mapping of Three Archetypal Chromosomes of Escherichia coli O157:H7 Involved in Three 2006 Outbreaks Associated with Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 41000659; 4885446 JF - 108th General Meeting of the American Society for Microbiology AU - Kotewicz, M L AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gene mapping KW - Outbreaks KW - Chromosomes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Characterization+by+Optical+Mapping+of+Three+Archetypal+Chromosomes+of+Escherichia+coli+O157%3AH7+Involved+in+Three+2006+Outbreaks+Associated+with+Fresh+Produce&rft.au=Kotewicz%2C+M+L%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Kotewicz&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a Genotyping DNA Microarray Representing Diverse Pathotypes of E.coli and Shigella sp for Strain Identification and Discrimination between and Within Closely Related Species T2 - 108th General Meeting of the American Society for Microbiology AN - 41000565; 4884704 JF - 108th General Meeting of the American Society for Microbiology AU - Jackson, S A AU - Patel, I AU - Mammel, M K AU - Mays, T AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Discrimination KW - DNA microarrays KW - Genotyping KW - Population genetics KW - Strains KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Use+of+a+Genotyping+DNA+Microarray+Representing+Diverse+Pathotypes+of+E.coli+and+Shigella+sp+for+Strain+Identification+and+Discrimination+between+and+Within+Closely+Related+Species&rft.au=Jackson%2C+S+A%3BPatel%2C+I%3BMammel%2C+M+K%3BMays%2C+T%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transposon Mutagenesis Shows that Genes Other than those Associated with csgBA(C) and bcsABZC Operons can Affect the Expression of Extracellular Cellulose and Curli in Cronobacter sp. (formerly Enterobacter sakazakii) T2 - 108th General Meeting of the American Society for Microbiology AN - 41000307; 4884985 JF - 108th General Meeting of the American Society for Microbiology AU - Datta, A R AU - Tall, B D AU - Kothary, M H AU - Sathyamoorthy, V AU - Everton, K S AU - Lee, C J AU - Carter, L AU - McCardell, B A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cellulose KW - Transposon mutagenesis KW - Operons KW - Mutagenesis KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Mechanism+of+Protection+Induced+by+a+Live+Attenuated+Matrix+Gene+%28M1%29+Mutant+Virus+Against+Homologous+and+Heterologous+Influenza+Challenges+in+Mice&rft.au=Xie%2C+Hang%3BWu%2C+Zhengqi%3BLiu%2C+Teresa%3BYe%2C+Zhiping&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Antimicrobial Resistance Monitoring System (NARMS) T2 - 108th General Meeting of the American Society for Microbiology AN - 40999466; 4886299 JF - 108th General Meeting of the American Society for Microbiology AU - White, D G Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Monitoring systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=National+Antimicrobial+Resistance+Monitoring+System+%28NARMS%29&rft.au=White%2C+D+G&rft.aulast=White&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of Ceftiofur by Bovine Fecal Bacteria T2 - 108th General Meeting of the American Society for Microbiology AN - 40999276; 4885136 JF - 108th General Meeting of the American Society for Microbiology AU - Williams, A J AU - Rafii, F AU - Park, M AU - Sims, L M AU - Jung, C M AU - Johnson, S J AU - Erickson, B D AU - Cerniglia, C E AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Fecal coliforms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Degradation+of+Ceftiofur+by+Bovine+Fecal+Bacteria&rft.au=Sauder%2C+Christian%3BZhang%2C+Cheryl%3BMalik%2C+Tahir%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Campylobacter jejuni 81-176 Induces Specific Phosphorylation/Dephosphorylation of Host Proteins during Invasion of Human Epithelial Cells T2 - 108th General Meeting of the American Society for Microbiology AN - 40999192; 4882754 JF - 108th General Meeting of the American Society for Microbiology AU - Hu, L. AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Dephosphorylation KW - Epithelial cells KW - Phosphorylation KW - Introduced species KW - Campylobacter jejuni KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Campylobacter+jejuni+81-176+Induces+Specific+Phosphorylation%2FDephosphorylation+of+Host+Proteins+during+Invasion+of+Human+Epithelial+Cells&rft.au=Hu%2C+L.%3BKopecko%2C+D+J&rft.aulast=Hu&rft.aufirst=L.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phylogenetic Diversity of Enterobacter sakazakii as Revealed by a Five-Gene Multilocus Sequence Analysis T2 - 108th General Meeting of the American Society for Microbiology AN - 40999067; 4883635 JF - 108th General Meeting of the American Society for Microbiology AU - Ramaseshan, A S AU - Keys, C E AU - Trujillo, S AU - Lampel, K A AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Phylogenetics KW - Species diversity KW - Nucleotide sequence KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phylogenetic+Diversity+of+Enterobacter+sakazakii+as+Revealed+by+a+Five-Gene+Multilocus+Sequence+Analysis&rft.au=Ramaseshan%2C+A+S%3BKeys%2C+C+E%3BTrujillo%2C+S%3BLampel%2C+K+A%3BBrown%2C+E+W&rft.aulast=Ramaseshan&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is 16S rDNA a Reliable Phylogenetic Marker to Characterize Taxonomic Relationships of Erwinia, Brenneria, and Pectobacterium? T2 - 108th General Meeting of the American Society for Microbiology AN - 40998987; 4883625 JF - 108th General Meeting of the American Society for Microbiology AU - Naum, M AU - Brown, E W AU - Mason-Gamer, R J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - RRNA 16S KW - Phylogenetics KW - Erwinia KW - Brenneria KW - Pectobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Is+16S+rDNA+a+Reliable+Phylogenetic+Marker+to+Characterize+Taxonomic+Relationships+of+Erwinia%2C+Brenneria%2C+and+Pectobacterium%3F&rft.au=Naum%2C+M%3BBrown%2C+E+W%3BMason-Gamer%2C+R+J&rft.aulast=Naum&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Survivability of Bacillus anthracis (Stern strain) in Processed Liquid Eggs T2 - 108th General Meeting of the American Society for Microbiology AN - 40998921; 4885032 JF - 108th General Meeting of the American Society for Microbiology AU - Khan, S A AU - Sung, K AU - Nawaz, M S AU - Cerniglia, C E AU - Kelly, L S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Eggs KW - Strains KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Investigation+of+the+Contribution+of+the+Surface+and+Matrix+Proteins+of+Mumps+Virus+Strain+Urabe+AM9+to+Neurovirulence&rft.au=Link%2C+Malen+A%3BSauder%2C+Christian%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn+M%3BRubin%2C+Steven&rft.aulast=Link&rft.aufirst=Malen&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Method to Isolate and Enrich for Francisella tularensis, Salmonella enteritidis and Listeria monocytogenes from Foods to Facilitate Subsequent Detection by Real-Time PCR T2 - 108th General Meeting of the American Society for Microbiology AN - 40998794; 4885005 JF - 108th General Meeting of the American Society for Microbiology AU - Day, J AU - Hao, D Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Food KW - Anadromous species KW - Nucleotide sequence KW - Salmonella enteritidis KW - Francisella tularensis KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+a+Method+to+Isolate+and+Enrich+for+Francisella+tularensis%2C+Salmonella+enteritidis+and+Listeria+monocytogenes+from+Foods+to+Facilitate+Subsequent+Detection+by+Real-Time+PCR&rft.au=Day%2C+J%3BHao%2C+D&rft.aulast=Day&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Transcriptomic Analysis of AcrA Function: The Membrane Fusion Protein of the Major Tripartite Multidrug Efflux Pump of Escherichia coli T2 - 108th General Meeting of the American Society for Microbiology AN - 40998568; 4882975 JF - 108th General Meeting of the American Society for Microbiology AU - Elkins, C A AU - Han, T AU - Mullis, L B AU - Fuscoe, J C Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Membrane proteins KW - Membrane fusion KW - Pumps KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Transcriptomic+Analysis+of+AcrA+Function%3A+The+Membrane+Fusion+Protein+of+the+Major+Tripartite+Multidrug+Efflux+Pump+of+Escherichia+coli&rft.au=Elkins%2C+C+A%3BHan%2C+T%3BMullis%2C+L+B%3BFuscoe%2C+J+C&rft.aulast=Elkins&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Development of a Validated DNA Microarray for Characterization of Salmonella enterica and Campylobacter from Retail Meats T2 - 108th General Meeting of the American Society for Microbiology AN - 40997775; 4885016 JF - 108th General Meeting of the American Society for Microbiology AU - Harbottle, H AU - Thakur, S AU - Vaughn, B AU - Kroft, B AU - Gebreyes, W AU - White, D G AU - McDermott, P F AU - Zhao, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - DNA microarrays KW - Meat KW - Anadromous species KW - Campylobacter KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40997775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Development+of+a+Validated+DNA+Microarray+for+Characterization+of+Salmonella+enterica+and+Campylobacter+from+Retail+Meats&rft.au=Harbottle%2C+H%3BThakur%2C+S%3BVaughn%2C+B%3BKroft%2C+B%3BGebreyes%2C+W%3BWhite%2C+D+G%3BMcDermott%2C+P+F%3BZhao%2C+S&rft.aulast=Harbottle&rft.aufirst=H&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-Time Multiplex PCR Assay for the Detection of Shigella in Foods T2 - 108th General Meeting of the American Society for Microbiology AN - 40997106; 4885019 JF - 108th General Meeting of the American Society for Microbiology AU - Deer, D M AU - Lampel, K A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Food KW - Nucleotide sequence KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40997106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Real-Time+Multiplex+PCR+Assay+for+the+Detection+of+Shigella+in+Foods&rft.au=Deer%2C+D+M%3BLampel%2C+K+A&rft.aulast=Deer&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Studies on the Fimbrial Subunit Promoters of Bordetella pertussis T2 - 108th General Meeting of the American Society for Microbiology AN - 40995864; 4884413 JF - 108th General Meeting of the American Society for Microbiology AU - Chen, Q AU - Boucher, P AU - Baxter, K AU - Hinton, D AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Promoters KW - Pertussis KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Studies+on+the+Fimbrial+Subunit+Promoters+of+Bordetella+pertussis&rft.au=Chen%2C+Q%3BBoucher%2C+P%3BBaxter%2C+K%3BHinton%2C+D%3BStibitz%2C+S&rft.aulast=Chen&rft.aufirst=Q&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Cellulose and Curli Multicellular Behavior Morphotypes among Cronobacter sp. (formerly Enterobacter sakazakii) T2 - 108th General Meeting of the American Society for Microbiology AN - 40995493; 4884984 JF - 108th General Meeting of the American Society for Microbiology AU - Tall, B D AU - Kothary, M H AU - Everton, K S AU - McCardell, B A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cellulose KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Expression+of+Cellulose+and+Curli+Multicellular+Behavior+Morphotypes+among+Cronobacter+sp.+%28formerly+Enterobacter+sakazakii%29&rft.au=Tall%2C+B+D%3BKothary%2C+M+H%3BEverton%2C+K+S%3BMcCardell%2C+B+A&rft.aulast=Tall&rft.aufirst=B&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Method to Isolate and Detect Shigella species from Produce Commodities T2 - 108th General Meeting of the American Society for Microbiology AN - 40995238; 4885020 JF - 108th General Meeting of the American Society for Microbiology AU - Hawkins, E AU - Tipton, A AU - Enurah, A AU - Lampel, K Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Method+to+Isolate+and+Detect+Shigella+species+from+Produce+Commodities&rft.au=Hawkins%2C+E%3BTipton%2C+A%3BEnurah%2C+A%3BLampel%2C+K&rft.aulast=Hawkins&rft.aufirst=E&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Taxonomic Utility of Six-Enzyme Pulsed-Field Gel Electrophoresis in Reconstructing Salmonella Phylogeny T2 - 108th General Meeting of the American Society for Microbiology AN - 40994238; 4883628 JF - 108th General Meeting of the American Society for Microbiology AU - Trujillo, S AU - Keys, C E AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Phylogeny KW - Electrophoresis KW - Pulsed-field gel electrophoresis KW - Anadromous species KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evaluation+of+the+Taxonomic+Utility+of+Six-Enzyme+Pulsed-Field+Gel+Electrophoresis+in+Reconstructing+Salmonella+Phylogeny&rft.au=Trujillo%2C+S%3BKeys%2C+C+E%3BBrown%2C+E+W&rft.aulast=Trujillo&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Real Time PCR Method for the Detection of Yersinia enterocolitica in Green Leafy Vegetables T2 - 108th General Meeting of the American Society for Microbiology AN - 40994067; 4884595 JF - 108th General Meeting of the American Society for Microbiology AU - Rodriguez, A A AU - Regan, P M AU - Margolin, A B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Vegetables KW - Polymerase chain reaction KW - Nucleotide sequence KW - Yersinia enterocolitica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+a+Real+Time+PCR+Method+for+the+Detection+of+Yersinia+enterocolitica+in+Green+Leafy+Vegetables&rft.au=Rodriguez%2C+A+A%3BRegan%2C+P+M%3BMargolin%2C+A+B&rft.aulast=Rodriguez&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Evaluation of Hepatitis A Virus Recoveries from Green Onions and Spinach Using Fluorogenic RT-PCR T2 - 108th General Meeting of the American Society for Microbiology AN - 40994066; 4885023 JF - 108th General Meeting of the American Society for Microbiology AU - Shieh, Y C AU - Laird, D T AU - Stewart, D S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Hepatitis A KW - Polymerase chain reaction KW - Hepatitis A virus KW - Spinacia oleracea KW - Allium cepa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Rapid+Evaluation+of+Hepatitis+A+Virus+Recoveries+from+Green+Onions+and+Spinach+Using+Fluorogenic+RT-PCR&rft.au=Shieh%2C+Y+C%3BLaird%2C+D+T%3BStewart%2C+D+S&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Multiple Strains of Norovirus in Oysters Implicated in an Outbreak of Acute Gastroenteritis T2 - 108th General Meeting of the American Society for Microbiology AN - 40992843; 4883161 JF - 108th General Meeting of the American Society for Microbiology AU - Woods, J W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gastroenteritis KW - Oysters KW - Outbreaks KW - Strains KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40992843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+of+Multiple+Strains+of+Norovirus+in+Oysters+Implicated+in+an+Outbreak+of+Acute+Gastroenteritis&rft.au=Woods%2C+J+W&rft.aulast=Woods&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Studies of Secreted Proteases of Bacillus anthracis T2 - 108th General Meeting of the American Society for Microbiology AN - 40991834; 4885832 JF - 108th General Meeting of the American Society for Microbiology AU - McNichol, B A AU - Grippe, V K AU - Lee, G M AU - Merkel, T J AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Proteinase KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40991834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Studies+of+Secreted+Proteases+of+Bacillus+anthracis&rft.au=McNichol%2C+B+A%3BGrippe%2C+V+K%3BLee%2C+G+M%3BMerkel%2C+T+J%3BStibitz%2C+S&rft.aulast=McNichol&rft.aufirst=B&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Biological Enrichment in Mammalian Cell Culture to Increase the Sensitivity of Mycoplasma Detection by Molecular Methods T2 - 108th General Meeting of the American Society for Microbiology AN - 40991536; 4884835 JF - 108th General Meeting of the American Society for Microbiology AU - Kong, H AU - Volokhov, D V AU - George, J AU - Anderson, C AU - Chizhikov, V E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cell culture KW - Mammalian cells KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40991536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Use+of+Biological+Enrichment+in+Mammalian+Cell+Culture+to+Increase+the+Sensitivity+of+Mycoplasma+Detection+by+Molecular+Methods&rft.au=Kong%2C+H%3BVolokhov%2C+D+V%3BGeorge%2C+J%3BAnderson%2C+C%3BChizhikov%2C+V+E&rft.aulast=Kong&rft.aufirst=H&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antimicrobial Resistant E. coli from Retail Chicken Breast and Slaughter Rinsates: NARMS 2002-2005 T2 - 108th General Meeting of the American Society for Microbiology AN - 40990436; 4884613 JF - 108th General Meeting of the American Society for Microbiology AU - McDermott, P AU - Anandaraman, N AU - Haro, J AU - Ball, T AU - Hall-Robinson, E AU - Blickenstaff, K AU - Carter, P AU - Fedorka-Cray, P Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Antimicrobial agents KW - Slaughter KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Antimicrobial+Resistant+E.+coli+from+Retail+Chicken+Breast+and+Slaughter+Rinsates%3A+NARMS+2002-2005&rft.au=McDermott%2C+P%3BAnandaraman%2C+N%3BHaro%2C+J%3BBall%2C+T%3BHall-Robinson%2C+E%3BBlickenstaff%2C+K%3BCarter%2C+P%3BFedorka-Cray%2C+P&rft.aulast=McDermott&rft.aufirst=P&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic Microarray of Escherichia coli O157:H7 Isolates from the 2006 Outbreaks Linked to Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 40990380; 4884607 JF - 108th General Meeting of the American Society for Microbiology AU - Mukherjee, A AU - Mammel, M K AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Outbreaks KW - Phenotypes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phenotypic+Microarray+of+Escherichia+coli+O157%3AH7+Isolates+from+the+2006+Outbreaks+Linked+to+Fresh+Produce&rft.au=Mukherjee%2C+A%3BMammel%2C+M+K%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Mukherjee&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic and Genotypic Characterization of Escherichia coli O157:H7 Isolates from 2006 Outbreaks Linked to Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 40990333; 4884605 JF - 108th General Meeting of the American Society for Microbiology AU - Li, B. AU - Gebru, S AU - George, G L AU - Roberson, D AU - Lacher, D W AU - Kotewicz, M L AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Outbreaks KW - Phenotypes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phenotypic+and+Genotypic+Characterization+of+Escherichia+coli+O157%3AH7+Isolates+from+2006+Outbreaks+Linked+to+Fresh+Produce&rft.au=Li%2C+B.%3BGebru%2C+S%3BGeorge%2C+G+L%3BRoberson%2C+D%3BLacher%2C+D+W%3BKotewicz%2C+M+L%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Li&rft.aufirst=B.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Campylobacter jejuni 81-176 Requires Lipid Rafts and Glycosylphosphatidylinositol (GPI)-Anchored Proteins for Human Epithelial Cell Adherence and Invasion T2 - 108th General Meeting of the American Society for Microbiology AN - 40989408; 4883254 JF - 108th General Meeting of the American Society for Microbiology AU - Shima, K AU - Giri, C P AU - Guerry, P AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Lipid rafts KW - Glycosylphosphatidylinositol KW - Epithelial cells KW - Campylobacter jejuni KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40989408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Campylobacter+jejuni+81-176+Requires+Lipid+Rafts+and+Glycosylphosphatidylinositol+%28GPI%29-Anchored+Proteins+for+Human+Epithelial+Cell+Adherence+and+Invasion&rft.au=Shima%2C+K%3BGiri%2C+C+P%3BGuerry%2C+P%3BKopecko%2C+D+J&rft.aulast=Shima&rft.aufirst=K&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of LC-MS Technology and Other Novel Subtyping Strategies to Detect Clusters of Foodborne Pathogenic Strains T2 - 108th General Meeting of the American Society for Microbiology AN - 40988773; 4886443 JF - 108th General Meeting of the American Society for Microbiology AU - Brown, E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Technology KW - Food KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Use+of+LC-MS+Technology+and+Other+Novel+Subtyping+Strategies+to+Detect+Clusters+of+Foodborne+Pathogenic+Strains&rft.au=Brown%2C+E&rft.aulast=Brown&rft.aufirst=E&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis of Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1 T2 - 108th General Meeting of the American Society for Microbiology AN - 40988426; 4884135 JF - 108th General Meeting of the American Society for Microbiology AU - Kim, S-J AU - Kweon, O-G AU - Jones, R C AU - Edmondson, R D AU - Cerniglia, C E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polycyclic aromatic hydrocarbons KW - Genomic analysis KW - Aromatic hydrocarbons KW - Mycobacterium vanbaalenii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genomic+Analysis+of+Polycyclic+Aromatic+Hydrocarbon+Degradation+in+Mycobacterium+vanbaalenii+PYR-1&rft.au=Kim%2C+S-J%3BKweon%2C+O-G%3BJones%2C+R+C%3BEdmondson%2C+R+D%3BCerniglia%2C+C+E&rft.aulast=Kim&rft.aufirst=S-J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vibrio cholerae O139 O-Antigen Gene Locus Requires Adjacent Group 4 Capsule Secretion Genes for Biosynthesis of Capsule, but Not LPS T2 - 108th General Meeting of the American Society for Microbiology AN - 40988088; 4883403 JF - 108th General Meeting of the American Society for Microbiology AU - Xu, D-Q AU - Johnson, J A AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Biosynthesis KW - Secretion KW - Lipopolysaccharides KW - Vibrio cholerae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vibrio+cholerae+O139+O-Antigen+Gene+Locus+Requires+Adjacent+Group+4+Capsule+Secretion+Genes+for+Biosynthesis+of+Capsule%2C+but+Not+LPS&rft.au=Xu%2C+D-Q%3BJohnson%2C+J+A%3BKopecko%2C+D+J&rft.aulast=Xu&rft.aufirst=D-Q&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and Molecular Characterization of Tetracycline-Resistant Escherichia coli Isolated from Catfish T2 - 108th General Meeting of the American Society for Microbiology AN - 40987419; 4884584 JF - 108th General Meeting of the American Society for Microbiology AU - Nawaz, M S AU - Khan, A A AU - Khan, S A AU - Sung, K AU - Steele, R S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Pathogens KW - Food KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40987419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Isolation+and+Molecular+Characterization+of+Tetracycline-Resistant+Escherichia+coli+Isolated+from+Catfish&rft.au=Nawaz%2C+M+S%3BKhan%2C+A+A%3BKhan%2C+S+A%3BSung%2C+K%3BSteele%2C+R+S&rft.aulast=Nawaz&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Class 1 Integron Resistance Genes Cassettes among Salmonella Strains from Imported Seafood T2 - 108th General Meeting of the American Society for Microbiology AN - 40986681; 4884567 JF - 108th General Meeting of the American Society for Microbiology AU - Khan, A A AU - Ponce, E AU - Cheng, C-M AU - Nawaz, M AU - Summage-West, C Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Seafood KW - Anadromous species KW - Strains KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language+Learning+and+Development&rft.atitle=Is+Infants%27+Learning+of+Sound+Patterns+Constrained+by+Phonological+Features%3F&rft.au=Cristi%C3%A1%2C+Alejandrina%3BSeidl%2C+Amanda&rft.aulast=Cristi%C3%A1&rft.aufirst=Alejandrina&rft.date=2008-07-01&rft.volume=4&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Language+Learning+and+Development&rft.issn=15475441&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Genomic Evaluation of Listeria monocytogenes Strains Involved in Invasive and Gastroenteritis Listeriosis Outbreaks T2 - 108th General Meeting of the American Society for Microbiology AN - 40986259; 4884114 JF - 108th General Meeting of the American Society for Microbiology AU - Burall, L S AU - Datta, A R Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gastroenteritis KW - Outbreaks KW - Listeriosis KW - Genomics KW - Strains KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Genomic+Evaluation+of+Listeria+monocytogenes+Strains+Involved+in+Invasive+and+Gastroenteritis+Listeriosis+Outbreaks&rft.au=Burall%2C+L+S%3BDatta%2C+A+R&rft.aulast=Burall&rft.aufirst=L&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevelance and Distribution of Noro- and Hepatitis A Viruses (HAV) in U.S. Market Shellfish T2 - 108th General Meeting of the American Society for Microbiology AN - 40986256; 4883160 JF - 108th General Meeting of the American Society for Microbiology AU - Burkhardt III, W AU - Calci, K AU - Williams-Hill, D AU - Tran, N AU - Thammasouk, K AU - Wetherington, J AU - Kasturi, K AU - Herbst, T AU - Lara, A AU - Williams, J AU - Kaewussdangkul, P AU - Romero, H AU - Jacobs, E AU - Patton, L AU - Swinford, A G AU - Woods, J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Hepatitis A KW - Shellfish KW - Viruses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Prevelance+and+Distribution+of+Noro-+and+Hepatitis+A+Viruses+%28HAV%29+in+U.S.+Market+Shellfish&rft.au=Simmons%2C+Janine+M%3BSaad%2C+Ziad+S%3BLizak%2C+Martin+J%3BOrtiz%2C+Michael%3BKoretsky%2C+Alan+P%3BRichmond%2C+Barry+J&rft.aulast=Simmons&rft.aufirst=Janine&rft.date=2008-07-23&rft.volume=28&rft.issue=30&rft.spage=7637&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1488-08.2008 L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design and Development of a Novel High Density Microarray Representative of Over 75 Complete Genome Sequences of Salmonella and Escherichia coli: Identifying Genes and SNPs T2 - 108th General Meeting of the American Society for Microbiology AN - 40985711; 4884701 JF - 108th General Meeting of the American Society for Microbiology AU - Jackson, S A AU - Mammel, M AU - Patel, I AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Genomes KW - Single-nucleotide polymorphism KW - Anadromous species KW - Escherichia coli KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Design+and+Development+of+a+Novel+High+Density+Microarray+Representative+of+Over+75+Complete+Genome+Sequences+of+Salmonella+and+Escherichia+coli%3A+Identifying+Genes+and+SNPs&rft.au=Jackson%2C+S+A%3BMammel%2C+M%3BPatel%2C+I%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recommendations for a Revised System of Nomenclature for Allelic Variants of Intimin (eae) T2 - 108th General Meeting of the American Society for Microbiology AN - 40985630; 4884688 JF - 108th General Meeting of the American Society for Microbiology AU - Lacher, D AU - Steinsland, H AU - Whittam, T Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Experimental allergic encephalomyelitis KW - Nomenclature KW - Intimin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Recommendations+for+a+Revised+System+of+Nomenclature+for+Allelic+Variants+of+Intimin+%28eae%29&rft.au=Lacher%2C+D%3BSteinsland%2C+H%3BWhittam%2C+T&rft.aulast=Lacher&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and Partial Characterization of a Novel Vibrio tubiashii Hemolysin Gene and the Development of a PCR Based Detection for V. tubiashii T2 - 108th General Meeting of the American Society for Microbiology AN - 40985497; 4884602 JF - 108th General Meeting of the American Society for Microbiology AU - Sathyamoorthy, V AU - Datta, A R AU - Lee, C J AU - Tall, B D AU - McCardell, B A AU - Kothary, M H Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Hemolysin KW - Disease detection KW - Nucleotide sequence KW - Vibrio tubiashii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Cloning+and+Partial+Characterization+of+a+Novel+Vibrio+tubiashii+Hemolysin+Gene+and+the+Development+of+a+PCR+Based+Detection+for+V.+tubiashii&rft.au=Sathyamoorthy%2C+V%3BDatta%2C+A+R%3BLee%2C+C+J%3BTall%2C+B+D%3BMcCardell%2C+B+A%3BKothary%2C+M+H&rft.aulast=Sathyamoorthy&rft.aufirst=V&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function and Expression of the hmu Heme Transport System in Corynebacterium Species T2 - 108th General Meeting of the American Society for Microbiology AN - 40984829; 4884294 JF - 108th General Meeting of the American Society for Microbiology AU - Schmitt, M P AU - Allen, C E AU - Kunkle, C A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Heme KW - Corynebacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Function+and+Expression+of+the+hmu+Heme+Transport+System+in+Corynebacterium+Species&rft.au=Schmitt%2C+M+P%3BAllen%2C+C+E%3BKunkle%2C+C+A&rft.aulast=Schmitt&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of Vibrio parahaemolyticus and V. vulnificus Levels in U.S. Market Oysters T2 - 108th General Meeting of the American Society for Microbiology AN - 40984657; 4884591 JF - 108th General Meeting of the American Society for Microbiology AU - Nordstrom, J L AU - Bowers, J C AU - Krantz, J A AU - Calci, K R AU - Byars, R AU - Johnson, J AU - Kasturi, K AU - Kawalek, M AU - Gonzalez, E AU - Obando, J AU - Versace, J AU - Phan, L AU - Thammasouk, K AU - Eliasberg, S AU - Chatman, L AU - Welch, J AU - DePaola, A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Oysters KW - Pathogenic bacteria KW - Vibrio parahaemolyticus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Distribution+of+Vibrio+parahaemolyticus+and+V.+vulnificus+Levels+in+U.S.+Market+Oysters&rft.au=Nordstrom%2C+J+L%3BBowers%2C+J+C%3BKrantz%2C+J+A%3BCalci%2C+K+R%3BByars%2C+R%3BJohnson%2C+J%3BKasturi%2C+K%3BKawalek%2C+M%3BGonzalez%2C+E%3BObando%2C+J%3BVersace%2C+J%3BPhan%2C+L%3BThammasouk%2C+K%3BEliasberg%2C+S%3BChatman%2C+L%3BWelch%2C+J%3BDePaola%2C+A&rft.aulast=Nordstrom&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation in the Effect of Exposure to Gatifloxacin on the Metabolic Activities of different Strains of Clostridium perfringens T2 - 108th General Meeting of the American Society for Microbiology AN - 40984056; 4884250 JF - 108th General Meeting of the American Society for Microbiology AU - Rafii, F AU - Park, M AU - Costa, G. Gamboa da Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gatifloxacin KW - Strains KW - Clostridium perfringens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Variation+in+the+Effect+of+Exposure+to+Gatifloxacin+on+the+Metabolic+Activities+of+different+Strains+of+Clostridium+perfringens&rft.au=Rafii%2C+F%3BPark%2C+M%3BCosta%2C+G.+Gamboa+da&rft.aulast=Rafii&rft.aufirst=F&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Practice-specific risk perceptions and self-reported food safety practices AN - 37079717; 3834855 AB - The relationship between risk perception and risk avoidance is typically analyzed using self-reported measures. However, in domains such as driving or food handling, the validity of responses about usual behavior is threatened because people think about the situations in which they are self-aware, such as when they encounter a hazard. Indeed, researchers have often noted a divergence between what people say about their behavior and how they actually behave. Thus, in order to draw conclusions about risk perceptions and risk avoidance from survey data, it is important to identify particular cognitive elements, such as those measured by questions about risk and safety knowledge, risk perceptions, or information search behavior, which may be effective antecedents of self-reported safety behavior. It is also important to identify and correct for potential sources of bias that may exist in the data. The authors analyze the Food and Drug Administration's 1998 Food Safety Survey to determine whether there are consistent cognitive antecedents for three types of safe food practices: preparation, eating, and cooling of foods. An assessment of measurement biases shows that endogeneity of food choices affects reports of food preparation. In addition, response bias affects reports of cooling practices as evidenced by its relation to knowledge and information search, a pattern of cognitive effects unique to cooling practices. After correcting for these biases, results show that practice-specific risk perceptions are the primary cognitive antecedents of safe food behavior, which has implications for the design of effective education messages about food safety. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Levy, Alan S AU - Choinière, Conrad J AU - Fein, Sara B AD - U.S. Food and Drug Administration Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 749 EP - 762 VL - 28 IS - 3 SN - 0272-4332, 0272-4332 KW - Sociology KW - Risk management KW - Measurement KW - Medical sociology KW - Food KW - Health education KW - Social perception KW - Surveys KW - Food safety KW - Human behaviour KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37079717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Practice-specific+risk+perceptions+and+self-reported+food+safety+practices&rft.au=Levy%2C+Alan+S%3BChoini%C3%A8re%2C+Conrad+J%3BFein%2C+Sara+B&rft.aulast=Levy&rft.aufirst=Alan&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01051.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5142 10449 5772; 7854; 6071 1542 11325; 7887 12008; 11883 9382; 12429; 10449 5772; 5779 4049; 5114; 11038 7625 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01051.x ER - TY - JOUR T1 - Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers AN - 21204288; 11178399 AB - Abstract not available. JF - AAPS Journal AU - Volpe, Donna A AU - Asafu-Adjaye, Ebenezer B AU - Ellison, Christopher D AU - Doddapaneni, Suresh AU - Uppoor, Ramana S AU - Khan, Mansoor A AD - Division of Product Quality Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993-0002, USA, donna.volpe@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 360 EP - 362 PB - American Association of Pharmaceutical Scientists VL - 10 IS - 2 SN - 1550-7416, 1550-7416 KW - Toxicology Abstracts KW - Permeability KW - Opioids KW - Drug abuse KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21204288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Effect+of+Ethanol+on+Opioid+Drug+Permeability+Through+Caco-2+Cell+Monolayers&rft.au=Volpe%2C+Donna+A%3BAsafu-Adjaye%2C+Ebenezer+B%3BEllison%2C+Christopher+D%3BDoddapaneni%2C+Suresh%3BUppoor%2C+Ramana+S%3BKhan%2C+Mansoor+A&rft.aulast=Volpe&rft.aufirst=Donna&rft.date=2008-06-01&rft.volume=10&rft.issue=2&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9046-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Permeability; Opioids; Drug abuse; Ethanol DO - http://dx.doi.org/10.1208/s12248-008-9046-3 ER - TY - JOUR T1 - Executive and Attention Functioning Among Children in the PANDAS Subgroup AN - 21124016; 11153714 AB - Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5-16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis. JF - Neuropsychology, Development, and Cognition. Section C: Child Neuropsychology AU - Hirschtritt, Matthew AU - Hammond, Christopher AU - Luckenbaugh, David AU - Buhle, Jason AU - Thurm, Audrey AU - Casey, B J AU - Swedo, Susan AD - Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA,Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 179 EP - 194 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 15 IS - 2 SN - 0929-7049, 0929-7049 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Streptococcus KW - Age KW - Pediatrics KW - Adolescence KW - Infection KW - Children KW - Cognition KW - Executive function KW - Intelligence KW - Mental disorders KW - Regression analysis KW - Obsessive compulsive disorder KW - Gilles de la Tourette syndrome KW - Sex KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Structural+stabilization+in+tetrameric+or+polymeric+hemoglobin+determines+its+interaction+with+endogenous+antioxidant+scavenger+pathways.&rft.au=Buehler%2C+Paul+W%3BVallelian%2C+Florence%3BMikolajczyk%2C+Malgorzata+G%3BSchoedon%2C+Gabriele%3BSchweizer%2C+Thomas%3BAlayash%2C+Abdu+I%3BSchaer%2C+Dominik+J&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/10.1089%2Fars.2008.2028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Adolescence; Children; Infection; Cognition; Executive function; Intelligence; Mental disorders; Regression analysis; Obsessive compulsive disorder; Gilles de la Tourette syndrome; Sex; Streptococcus DO - http://dx.doi.org/10.1080/09297040802186899 ER - TY - JOUR T1 - Detection and Quantification of Group C Rotaviruses in Communal Sewage AN - 20953094; 8299592 AB - Group C rotaviruses have been recognized as a cause of acute gastroenteritis in humans, cattle, and swine, although the true epidemiologic and clinical importance of this virus in these hosts has not yet been fully established. A real-time PCR assay based on a broadly reactive primer pair was developed and used to quantitatively determine the viral load of group C rotaviruses in environmental samples. A total of 35 raw and 35 treated sewage samples collected at the same sampling time in four Hungarian sewage treatment plants during a survey in 2005 were tested for the presence of group C rotaviruses. The overall detection rates were 91% (32 of 35) for the influent and 57% (20 of 35) for the effluent samples. Molecular characterization of the amplified partial VP6 gene revealed the cocirculation of human and animal (i.e., bovine and porcine) strains that were easily distinguishable by melting curve analysis. Human strains yielded relatively high viral loads (mean, 1.2 x 10 super(7); median, 6.9 x 10 super(5) genome equivalents per liter influent sewage) and appeared to display seasonal activity over the study period, whereas animal strains appeared to circulate throughout the year at much lower average titers (bovine strains mean, 9.9 x 10 super(4); median, 3.0 x 10 super(4); porcine strains mean, 3.9 x 10 super(4); median, 3.1 x 10 super(4) genome equivalents per liter influent sewage). Our findings suggest that monitoring of communal sewage may provide a good surrogate for investigating the epidemiology and ecology of group C rotaviruses in humans and animals. JF - Applied and Environmental Microbiology AU - Meleg, Edina AU - Banyai, Krisztian AU - Martella, Vito AU - Jiang, Baoming AU - Kocsis, Bela AU - Kisfali, Peter AU - Melegh, Bela AU - Szuecs, Gyoergy AD - Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadsag ut 7, H-7623 Pecs, Hungary. Department of Animal Health and Well-Being, University of Bari, Sp Casamassima Km 3, 70010 Valenzano, Bari, Italy. Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, Georgia 30333. Department of Medical Microbiology and Immunology. Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pecs, Szigeti ut 12, H-7624 Pecs, Hungary Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 3394 EP - 3399 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 11 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts; Virology & AIDS Abstracts; Water Resources Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Assay KW - Sewage KW - Viruses KW - SW 3040:Wastewater treatment processes KW - AQ 00006:Sewage KW - V 22300:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20953094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Science+%28Online%29&rft.atitle=Mechanisms+underlying+accent+accommodation+in+early+word+learning%3A+evidence+for+general+expansion&rft.au=Schmale%2C+Rachel%3BSeidl%2C+Amanda%3BCristia%2C+Alejandrina&rft.aulast=Schmale&rft.aufirst=Rachel&rft.date=2015-07-01&rft.volume=18&rft.issue=4&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Developmental+Science+%28Online%29&rft.issn=&rft_id=info:doi/10.1111%2Fdesc.12244 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Sewage; Viruses ER - TY - JOUR T1 - In vitro acetylcholinesterase inhibition and cytotoxic effect of some organophosphorus pesticides in human erythrocytes and HepG2 cells AN - 20944950; 8508039 AB - In vitro effects of some novel organophosphates like RPR-II, RPR-V, chlorpyrifos, dimethoate and monocrotophos (MCP) were studied in human erythrocytes with special reference to acetylcholinesterase (AChE) and mitochondrial function (MTT assay) in HepG2 cell lines. The purpose of the present study was to quantify "in vitro" effect by means of the 50 percent inhibition (IC sub(50) using acetylthiocholine iodide as substrate in human RBC in the presence of different concentrations of pesticides. Our study indicated dose dependent AChE inhibition by all the OP compounds tested. The IC sub(50) observed for RPR-II, RPR-V and chlorpyrifos was greater than 10 mM, whereas dimethoate and MCP showed 1.60 and 2.38 mM respectively showing dimethoate 1.48 times more potent than MCP. The kinetic constant (Vmax and Km) showed the trend of decreasing with all the compounds assayed indicating non-competative inhibition. Similarly, the cell viability (MTT) also decreased by all the tested five OP compounds. RPR-II and RPR-V were found to be least toxic and IC sub(50) observed was greater than 10 mM, whereas IC sub(50) observed for chlorpyrifos, dimethoate and MCP were 0.835, 0.850 and 0.576 mM respectively. These results indicated dose dependent cytotoxic effect by all these OP compounds on HepG2 cell lines and relatively MCP was most potent in comparison to other compounds tested. From the present study, it can be concluded that the in vitro AChE and MTT assays are sensitive assays and can be used as biochemical marker for the exposure of organophosphates. JF - Toxicology International AU - Rahman, M F AU - Mahboob, M AU - Grover, P AD - Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas - 72079, USA, rahman1030@gmail.com Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 49 EP - 55 VL - 15 IS - 1 SN - 0971-6580, 0971-6580 KW - Toxicology Abstracts KW - Chlorpyrifos KW - Pesticides (organophosphorus) KW - Cytotoxicity KW - Biochemical markers KW - Acetylcholinesterase KW - Kinetics KW - Erythrocytes KW - monocrotophos KW - Mitochondria KW - Dimethoate KW - organophosphates KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+International&rft.atitle=In+vitro+acetylcholinesterase+inhibition+and+cytotoxic+effect+of+some+organophosphorus+pesticides+in+human+erythrocytes+and+HepG2+cells&rft.au=Rahman%2C+M+F%3BMahboob%2C+M%3BGrover%2C+P&rft.aulast=Rahman&rft.aufirst=M&rft.date=2008-06-01&rft.volume=15&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Toxicology+International&rft.issn=09716580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Pesticides (organophosphorus); Biochemical markers; Cytotoxicity; Acetylcholinesterase; Kinetics; Erythrocytes; monocrotophos; Mitochondria; organophosphates; Dimethoate ER - TY - JOUR T1 - Targeting IL-13Ra2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin AN - 20915767; 8340916 AB - We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ra2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts, and other cells, and a chimeric fusion protein composed of human IL-13 and mutated Pseudomonas exotoxin (IL-13-PE38) is highly and specifically cytotoxic to these cells in vitro and in vivo. To improve the specificity for the target, we isolated specific antibodies against IL-13Ra2 from human single-chain Fv (scFv) antibody phage library and developed immunotoxin by selecting two high-affinity clones of scFv and fused to PE. The fusion chimeric gene was expressed in Escherichia coli, and highly purified IL-13R-specific immunotoxin, termed anti-IL-13Ra2(scFv)-PE38, was tested for its cytotoxicity. This molecule was highly cytotoxic to U251 glioma and PM-RCC renal cell carcinoma cell lines in vitro. The cytotoxic activity was neutralized by purified extracellular domain of IL-13Ra2 but not by IL-13, indicating that cytotoxic activity is specific. Anti-IL-13Ra2(scFv)-PE38 showed significant antitumor activity in immunodeficient mice with s.c. glioma tumors. Both i.p. and i.t. routes of administration showed antitumor activity in a dose-dependent manner. The maximum tolerated dose of anti-IL-13Ra2(scFv)-PE38 was 200 kg/kg i.p. twice daily for 5 days. These results indicate that anti-IL-13Ra2(scFv)-PE38 is a highly selective therapeutic agent for cancer therapy and should be further tested in animal models of human cancer. [Mol Cancer Ther 2008; 7(6):1579-87] JF - Molecular Cancer Therapeutics AU - Kioi, Mitomu AU - Seetharam, Saraswathy AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1579 EP - 1587 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 7 IS - 6 SN - 1535-7163, 1535-7163 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Phages KW - Animal models KW - Immunodeficiency KW - Pseudomonas KW - Tumors KW - Fv KW - Exotoxins KW - Immunotoxins KW - Fibroblasts KW - Brain tumors KW - Tumor cell lines KW - Interleukin 13 KW - Antibodies KW - Cytotoxicity KW - renal cell carcinoma KW - Gene fusion KW - Escherichia coli KW - Glioma KW - Fusion protein KW - Antitumor activity KW - J 02410:Animal Diseases KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20915767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Targeting+IL-13Ra2-positive+cancer+with+a+novel+recombinant+immunotoxin+composed+of+a+single-chain+antibody+and+mutated+Pseudomonas+exotoxin&rft.au=Kioi%2C+Mitomu%3BSeetharam%2C+Saraswathy%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2008-06-01&rft.volume=7&rft.issue=6&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phages; Immunodeficiency; Animal models; Tumors; Immunotoxins; Exotoxins; Fv; Fibroblasts; Brain tumors; Cytotoxicity; Antibodies; Interleukin 13; Tumor cell lines; renal cell carcinoma; Gene fusion; Fusion protein; Glioma; Antitumor activity; Escherichia coli; Pseudomonas ER - TY - JOUR T1 - Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle AN - 20890100; 8308959 AB - Rationale: Behavioral and anatomical data suggest that the ventral striatum, consisting of the nucleus accumbens and olfactory tubercle, is functionally heterogeneous. Cocaine and d-amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core. Objectives: We sought to determine whether rats self-administer the popular recreational drug ( plus or minus )-3,4-methylenedioxymethamphetamine (MDMA) into ventrostriatal subregions and whether the medial olfactory tubercle and medial accumbens shell mediate MDMA's positive reinforcing effects more effectively than their lateral counterparts. Results: Rats receiving 30 mM MDMA into the medial olfactory tubercle, medial accumbens shell, or accumbens core, but not the lateral tubercle or lateral shell, showed higher self-administration rates than rats receiving vehicle. The medial shell supported more vigorous self-administration of MDMA at higher concentrations than the core or medial olfactory tubercle. In addition, intra-medial shell MDMA self-administration was disrupted by co-administration of the D1 or D2 receptor antagonists SCH 23390 (1-3 mM) or raclopride (3-10 mM). Conclusions: Our data suggest that the ventral striatum is functionally heterogeneous. The medial accumbens shell appears to be more important than other ventrostriatal subregions in mediating the positive reinforcing effects of MDMA via both D1- and D2-type receptors. Together with previous data, our data also suggest that unidentified actions of MDMA interfere with the positive reinforcing effects of dopamine in the medial olfactory tubercle. JF - Psychopharmacology AU - Shin, Rick AU - Qin, Mei AU - Liu, Zhong-Hua AU - Ikemoto, Satoshi AD - US Department of Health and Human Services, 251 Bayview Boulevard, Room 08A711, Baltimore, MD, 21224, USA, sikemoto@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 261 EP - 270 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 198 IS - 2 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Dopamine D2 receptors KW - Nucleus accumbens KW - raclopride KW - Dopamine D1 receptors KW - Drug abuse KW - MDMA KW - Olfactory bulb KW - Antagonists KW - Neostriatum KW - Amphetamine KW - Cocaine KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20890100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Intracranial+self-administration+of+MDMA+into+the+ventral+striatum+of+the+rat%3A+differential+roles+of+the+nucleus+accumbens+shell%2C+core%2C+and+olfactory+tubercle&rft.au=Shin%2C+Rick%3BQin%2C+Mei%3BLiu%2C+Zhong-Hua%3BIkemoto%2C+Satoshi&rft.aulast=Shin&rft.aufirst=Rick&rft.date=2008-06-01&rft.volume=198&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Nucleus accumbens; raclopride; Neostriatum; Dopamine D1 receptors; Amphetamine; Drug abuse; Cocaine; MDMA; Antagonists; Olfactory bulb; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-008-1131-x ER - TY - JOUR T1 - Anthrax Lethal Toxin Enhances TNF-Induced Endothelial VCAM-1 Expression via an IFN Regulatory Factor-1-Dependent Mechanism AN - 20825763; 8303160 AB - Impaired host defenses and vascular dysfunction are hallmarks of the late, antibiotic-refractory stages of systemic anthrax infection. Anthrax lethal toxin (LT), a key virulence factor of Bacillus anthracis, was previously shown to enhance VCAM-1 expression on primary human endothelial cells suggesting a causative link between dysregulated adhesion molecule expression and the poor immune response and vasculitis associated with anthrax. In this study, we report that LT amplification of TNF-induced VCAM-1 expression is driven transcriptionally by the cooperative activation of NF-B and IFN regulatory factor-1 (IRF-1). LT enhancement of NF-B phosphorylation and nuclear translocation correlated temporally with a delayed reaccumulation of IBa, while increased induction of IRF-1 was linked to STAT1 activation. LT failed to augment TNF-induced ICAM-1 or E-selectin expression, two adhesion molecules regulated by NF-B, but not IRF-1. These results suggest that LT can differentially modulate NF-B target genes and highlight the importance of IRF-1 in VCAM-1 enhancement. Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which LT contributes to anthrax pathogenesis. JF - Journal of Immunology AU - Warfel, Jason M AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057 Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 7516 EP - 7524 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 11 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anthrax lethal toxin KW - Vasculitis KW - virulence factors KW - Bacillus anthracis KW - Infection KW - Endothelial cells KW - Interferon KW - Nuclear transport KW - vascular cell adhesion molecule 1 KW - Phosphorylation KW - Stat1 protein KW - Transcription factors KW - NF-B protein KW - Interferon regulatory factor 1 KW - intercellular adhesion molecule 1 KW - Anthrax KW - Immune response KW - E-selectin KW - Cell adhesion molecules KW - Vascular system KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20825763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Anthrax+Lethal+Toxin+Enhances+TNF-Induced+Endothelial+VCAM-1+Expression+via+an+IFN+Regulatory+Factor-1-Dependent+Mechanism&rft.au=Warfel%2C+Jason+M%3BD%27Agnillo%2C+Felice&rft.aulast=Warfel&rft.aufirst=Jason&rft.date=2008-06-01&rft.volume=180&rft.issue=11&rft.spage=7516&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Vasculitis; virulence factors; Infection; Endothelial cells; vascular cell adhesion molecule 1; Nuclear transport; Interferon; Phosphorylation; Stat1 protein; Transcription factors; intercellular adhesion molecule 1; Interferon regulatory factor 1; NF-B protein; Anthrax; Immune response; Cell adhesion molecules; E-selectin; Vascular system; Bacillus anthracis ER - TY - JOUR T1 - An interlaboratory study of perfluorinated alkyl compound levels in human plasma AN - 20823364; 8257686 AB - We conducted an interlaboratory study which differed from the typical study of this type because of its emphasis on comparing intralaboratory variability in results. We sent specimens to six laboratories experienced in the analysis of perfluorinated alkyl compounds in blood matrices and that use stringent procedures to control and assure accuracy and precision. Each received an identical set of 60 plasma specimens that were analyzed in six completely independent batches. Split specimens were included so that within- and between-batch coefficients of variation could be calculated. All laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS). The concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) measured in the specimens in general showed a high level of agreement, although in some cases the agreement was only moderate. The average within- and between-batch coefficient of variation for PFOS was 9.1% and 9.3%; for PFOA was 14.5% and 14.5%; and for PFHxS was 14.5% and 17.0%. The recent availability of labeled internal standards, among other advances, has facilitated improvement in the accuracy and precision of the assays. Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision. JF - Environmental Research AU - Longnecker, M P AU - Smith, C S AU - Kissling, GE AU - Hoppin, JA AU - Butenhoff, J L AU - Decker, E AU - Ehresman, D J AU - Ellefson, ME AU - Flaherty, J AU - Gardner AU - Langlois, E AU - LeBlanc, A AU - Lindstrom, AB AU - Reagen, W K AU - Strynar, MJ AU - Studabaker, W B AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA, longnec1@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 152 EP - 159 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 107 IS - 2 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts KW - Blood KW - Mass spectroscopy KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=An+interlaboratory+study+of+perfluorinated+alkyl+compound+levels+in+human+plasma&rft.au=Longnecker%2C+M+P%3BSmith%2C+C+S%3BKissling%2C+GE%3BHoppin%2C+JA%3BButenhoff%2C+J+L%3BDecker%2C+E%3BEhresman%2C+D+J%3BEllefson%2C+ME%3BFlaherty%2C+J%3BGardner%3BLanglois%2C+E%3BLeBlanc%2C+A%3BLindstrom%2C+AB%3BReagen%2C+W+K%3BStrynar%2C+MJ%3BStudabaker%2C+W+B&rft.aulast=Longnecker&rft.aufirst=M&rft.date=2008-06-01&rft.volume=107&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2008.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Blood; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.envres.2008.01.005 ER - TY - JOUR T1 - Leveraging Exploratory Investigational New Drug Studies to Accelerate Drug Development AN - 20820493; 8301331 AB - In 2006, the U.S. Food and Drug Administration published its guide on exploratory investigational new drug (IND) studies with the goal of making the approach to early-stage, pilot clinical trials more flexible within the context of current regulations. The exploratory IND allows sponsors to initiate clinical trials of limited scale with reduced preclinical requirements. These studies may be important vehicles for the conduct of proof-of-principle pharmacodynamic investigations of highly potent molecules, for bioavailability studies that require only a single drug dose to be administered, and for imaging trials that permit critical dosimetry and biodistribution investigations of new molecules. These trials were done with no therapeutic intent and must be followed by traditional dose-escalation investigations that are supported by standard preclinical toxicologic and pharmacologic studies. To the extent that they allow early evaluations of essential drug characteristics that can only be obtained in humans, exploratory IND trials have the potential to limit the cost and improve the development times of new agents. JF - Clinical Cancer Research AU - Jacobson-Kram, David AU - Mills, George AD - Authors' Affiliations: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland and Perceptive Informatics, Waltham, Massachusetts Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 3670 EP - 3674 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 14 IS - 12 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Bioavailability KW - Dosimetry KW - Drug development KW - Clinical trials KW - imaging KW - Pharmacodynamics KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20820493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Leveraging+Exploratory+Investigational+New+Drug+Studies+to+Accelerate+Drug+Development&rft.au=Jacobson-Kram%2C+David%3BMills%2C+George&rft.aulast=Jacobson-Kram&rft.aufirst=David&rft.date=2008-06-01&rft.volume=14&rft.issue=12&rft.spage=3670&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bioavailability; Dosimetry; Drug development; imaging; Clinical trials; Pharmacodynamics ER - TY - JOUR T1 - Age and gender affect DNMT3a and DNMT3b expression in human liver AN - 20688943; 8161705 AB - DNA methylation is catalyzed by a family of DNA methyltransferases (DNMTs) including the maintenance enzyme DNMT 1 and de novo methyltransferases DNMT 3a and DNMT 3b. Elevated levels of DNMTs have been found in cancer cells and in several types of human tumors. A polymorphism found in DNMT3b has been associated with increased risk for several cancers. The factors influencing DNMT expression in human tissues have not been clearly determined. he present study examined TDNMT3a and DNMT3b levels in human liver tissue samples and compared the effect of ageing, cigarette smoking, and gender. DNMT3a and DNMT3b expression levels in the samples from older individuals (56-78 years, n = 28) were both significantly higher than those of the younger group (16-48 years, n = 27) (73.2 plus or minus 3.4 vs 8.3 plus or minus 2.8 and 56.1 plus or minus 1.9 vs 17.5 plus or minus 5.7, respectively; p < 0.05). Levels of DNMT3b in females were significantly higher than those in males (75.4 plus or minus 2.2 vs 16.3 plus or minus 4.7; p < 0.05); however, DNMT3a levels were similar for females and males (52.7 plus or minus 2.7 vs 48.4 plus or minus 2.0). Expression levels of DNMT3a and DNMT3b were similar in smokers and nonsmokers (58.1 plus or minus 3.5 vs 60.8 plus or minus 3.1 and 54.5 plus or minus 2.3 vs 48.3 plus or minus 1.8, respectively). Genotyping for DNMT3b (C arrow right T) variant in this sample pool showed a frequency distribution of CC (41%), CT (50%), and TT (9%). The findings from this study suggest that ageing and gender may be important factors influencing DNA methylation status. JF - Cell Biology and Toxicology AU - Xiao, Yongmei AU - Word, Beverly AU - Starlard-Davenport, Atena AU - Haefele, Aaron AU - Lyn-Cook, Beverly D AU - Hammons, George AD - National Center for Toxicological Research, Jefferson, AR, 72079, USA, ghammons@nctr.fda.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 265 EP - 272 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 24 IS - 3 SN - 0742-2091, 0742-2091 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Age KW - Methyltransferase KW - Genotyping KW - Aging KW - Cigarette smoking KW - Liver KW - DNA methylation KW - DNA methyltransferase KW - Enzymes KW - Tumors KW - Cancer KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20688943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infancy&rft.atitle=Test-Retest+Reliability+in+Infant+Speech+Perception+Tasks&rft.au=Cristia%2C+Alejandrina%3BSeidl%2C+Amanda%3BSingh%2C+Leher%3BHouston%2C+Derek&rft.aulast=Cristia&rft.aufirst=Alejandrina&rft.date=2016-09-01&rft.volume=21&rft.issue=5&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Infancy&rft.issn=15250008&rft_id=info:doi/10.1111%2Finfa.12127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Methyltransferase; Genotyping; Cigarette smoking; Aging; DNA methylation; Liver; Enzymes; DNA methyltransferase; Tumors; Cancer DO - http://dx.doi.org/10.1007/s10565-007-9035-9 ER - TY - JOUR T1 - Modeling Neonatal Thimerosal Exposure in Mice AN - 20677092; 8204111 JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Issac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, GJean AD - Department of Neurological Surgery and the Center for Children's Environmental Health, University of California Davis, California 95616. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Stereology Resource Center, 104 Ringneck Court, Chester, Maryland 21619. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 416 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - thimerosal KW - Neonates KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Modeling+Neonatal+Thimerosal+Exposure+in+Mice&rft.au=Berman%2C+Robert+F%3BPessah%2C+Issac+N%3BMouton%2C+Peter+R%3BMav%2C+Deepak%3BHarry%2C+GJean&rft.aulast=Berman&rft.aufirst=Robert&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - thimerosal; Neonates ER - TY - JOUR T1 - Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis AN - 20624661; 9350050 AB - Objective We sought to identify specific occupational activities associated with functional limitations and radiographic damage in patients with longstanding ankylosing spondylitis (AS). Methods We asked patients diagnosed with AS for 20 years to report all past occupations, which we mapped to specific physical activities using the Occupational Information Network, which is the US Department of Labor job classification database. For each occupation reported, we obtained ratings for 13 physical abilities of the worker and 13 aspects of the work environment or work tasks (work context) thought to be most relevant to patients with AS. Averages for each measure, weighted by the number of years in each job, were related to the degree of functional limitation as assessed by the Bath AS Functional Index (BASFI) and to the extent of spinal radiographic damage as assessed by the Bath AS Radiology Index for the spine (BASRI-s). Results Among 397 patients, those with a history of jobs requiring dynamic flexibility (the ability to repeatedly bend, stretch, twist, or reach) had more functional limitations than those whose past jobs required little or no dynamic flexibility (adjusted mean BASFI score 48.3 in the top quartile versus 38.1 in all others). Those whose past jobs required more dynamic flexibility, extent flexibility, and exposure to whole body vibration also had significantly higher BASRI-s scores. Conclusion Bending, twisting, and stretching are the occupational activities associated with greater functional limitations and radiographic damage in patients with longstanding AS. Exposure to whole body vibration was also associated with more radiographic damage. JF - Arthritis & Rheumatism AU - Ward, Michael M AU - Reveille, John D AU - Learch, Thomas J AU - Davis, John C AU - Weisman, Michael H AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland, wardm1@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 822 EP - 832 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 6 SN - 0004-3591, 0004-3591 KW - Toxicology Abstracts KW - Vibrations KW - Computer programs KW - Databases KW - Workers KW - Ankylosing spondylitis KW - Spine KW - Baths KW - Classification KW - Physical activity KW - Radiology KW - Occupational exposure KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20624661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+cell+carcinoma%2C+occupational+pesticide+exposure+and+modification+by+glutathione+S-transferase+polymorphisms.&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BRothman%2C+N%3BHung%2C+R+J%3BStewart%2C+T%3BZaridze%2C+D%3BNavritalova%2C+M%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N%3BHolcatova%2C+I%3BMukeria%2C+A%3BGromiec%2C+J%3BChanock%2C+S+J%3BBrennan%2C+P%3BChow%2C+W-H%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vibrations; Workers; Databases; Computer programs; Spine; Ankylosing spondylitis; Classification; Baths; Physical activity; Radiology; Occupational exposure DO - http://dx.doi.org/10.1002/art.23704 ER - TY - JOUR T1 - Aerosolization of Single-Walled Carbon Nanotubes for an Inhalation Study AN - 20235574; 10310424 AB - Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities because of high interest in applications resulting from their unique properties. Because of potential respiratory exposures during production and handling, inhalation studies are needed to determine potential toxicity. A generation system was designed to produce respirable aerosol at 5 mg/m3 for a 1-wk animal (mouse) exposure. The starting material used in these experiments was as-produced powder from the high pressure carbon monoxide method that was sieved to number 6 mesh (< 2.3 mm). An acoustic feeder system was developed that handled the SWCNT powder without causing compaction of the material. The feed rate was adjustable, allowing output concentrations as high as 25 mg/m3. The powder particles were reduced in size using a mill that produced high shear forces, tearing the agglomerates apart. The resulting aerosol was size-separated using a settling chamber and two cyclones to produce a respirable aerosol. The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%. JF - Inhalation Toxicology AU - Baron, Paul AU - Deye, Gregory AU - Chen, Bean AU - Schwegler-Berry, Diane AU - Shvedova, Anna AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 751 EP - 760 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 20 IS - 8 SN - 0895-8378, 0895-8378 KW - Toxicology Abstracts KW - Inhalation KW - Carbon monoxide KW - Cyclones KW - Powder KW - Aerosols KW - Acoustics KW - nanotubes KW - Toxicity KW - Pressure KW - Compaction KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+Toxicology&rft.atitle=Aerosolization+of+Single-Walled+Carbon+Nanotubes+for+an+Inhalation+Study&rft.au=Baron%2C+Paul%3BDeye%2C+Gregory%3BChen%2C+Bean%3BSchwegler-Berry%2C+Diane%3BShvedova%2C+Anna%3BCastranova%2C+Vincent&rft.aulast=Baron&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=20&rft.issue=8&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Inhalation+Toxicology&rft.issn=08958378&rft_id=info:doi/10.1080%2F08958370801975303 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclones; Carbon monoxide; Inhalation; Powder; Aerosols; Acoustics; nanotubes; Toxicity; Pressure; Compaction DO - http://dx.doi.org/10.1080/08958370801975303 ER - TY - JOUR T1 - Dopamine and reward: The anhedonia hypothesis 30 years on AN - 20143491; 10263374 AB - The anhedonia hypothesis -- that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards -- was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. The hypothesis called to attention the apparent paradox that neuroleptics, drugs used to treat a condition involving anhedonia (schizophrenia), attenuated in laboratory animals the positive reinforcement that we normally associate with pleasure. The hypothesis held only brief interest for psychiatrists, who pointed out that the animal studies reflected acute actions of neuroleptics whereas the treatment of schizophrenia appears to result from neuroadaptations to chronic neuroleptic administration, and that it is the positive symptoms of schizophrenia that neuroleptics alleviate, rather than the negative symptoms that include anhedonia. Perhaps for these reasons, the hypothesis has had minimal impact in the psychiatric literature. Despite its limited heuristic value for the understanding of schizophrenia, however, the anhedonia hypothesis has had major impact on biological theories of reinforcement, motivation, and addiction. Brain dopamine plays a very important role in reinforcement of response habits, conditioned preferences, and synaptic plasticity in cellular models of learning and memory. The notion that dopamine plays a dominant role in reinforcement is fundamental to the psychomotor stimulant theory of addiction, to most neuroadaptation theories of addiction, and to current theories of conditioned reinforcement and reward prediction. Properly understood, it is also fundamental to recent theories of incentive motivation. JF - Neurotoxicity Research AU - Wise, Roy A AD - Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA, rwise@intra.nida.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 169 EP - 183 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 14 IS - 2-3 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Opiates KW - Motivation KW - Food KW - Emotional behavior KW - Conditioned reinforcement KW - Brain KW - Laboratory animals KW - Plasticity (synaptic) KW - Psychomotor stimulants KW - Schizophrenia KW - Mental disorders KW - Memory KW - Dopamine KW - Neuroleptics KW - Neurotoxicity KW - Reinforcement KW - Problem solving KW - Addiction KW - Attention KW - Hedonic response KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Dopamine+and+reward%3A+The+anhedonia+hypothesis+30+years+on&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2008-06-01&rft.volume=14&rft.issue=2-3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Opiates; Motivation; Food; Conditioned reinforcement; Emotional behavior; Laboratory animals; Brain; Plasticity (synaptic); Psychomotor stimulants; Schizophrenia; Memory; Mental disorders; Dopamine; Neuroleptics; Neurotoxicity; Reinforcement; Problem solving; Addiction; Hedonic response; Attention DO - http://dx.doi.org/10.1007/BF03033808 ER - TY - JOUR T1 - Heme-oxygenase 1 Gene Expression is a Marker for Hexavalent Chromium-Induced Stress and Toxicity in Human Dermal Fibroblasts AN - 19891353; 8204100 AB - Several adverse health effects, including irritant and allergic contact dermatitis, have been reported among workers who are occupationally exposed to chromium-containing compounds. Human dermal fibroblasts were used as an in vitro experimental model to study the potential mechanisms underlying hexavalent chromium [Cr(VI)]-induced dermal toxicity. Exposure of the fibroblasts to 5 mu M Cr(VI) (LC50 for a 24-h exposure period) followed by microarray analysis of the gene expression profile revealed overexpression of several genes including those involved in cell stress response. The cellular level of glutathione, the major antioxidant molecule present in the cells, was significantly lower in the Cr(VI)-treated cells compared to the corresponding control cells. The Cr(VI)-induced overexpression of heme-oxygenase 1 messenger RNA (HO-1) in the fibroblasts was significantly blocked by actinomycin D and by inhibitors of MAP kinase pathways. The Cr(VI)-induced cytotoxicity and the overexpression of the HO-1 gene were dependent on the glutathione level of the fibroblasts. Buthionine sulfoximine-mediated GSH depletion resulted in enhanced Cr(VI) cytotoxicity and further overexpression of the HO-1 gene. On the other hand, elevated cellular levels of glutathione resulting from pretreating the cells with GSH significantly protected the cells against the Cr(VI)-induced cytotoxicity and blocked the HO-1 gene's overexpression. Pretreating the fibroblasts with N-acetyl cysteine also significantly reduced the Cr(VI)-induced cytotoxicity and overexpression of the HO-1 gene. In conclusion, depletion of GSH leading to cellular stress is a major mechanism responsible for Cr(VI)-induced cytotoxicity. Furthermore, the expression level of HO-1 gene is a marker for Cr(VI)-induced cell stress leading to cytotoxicity. JF - Toxicological Sciences AU - Joseph, Pius AU - He, Quanren AU - Umbright, Christina AD - Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 325 EP - 334 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Toxicology Abstracts KW - MAP kinase KW - Skin KW - Antioxidants KW - Contact dermatitis KW - Chromium KW - Glutathione KW - Stress KW - Heme oxygenase (decyclizing) KW - Toxicity KW - mRNA KW - Fibroblasts KW - Gene expression KW - Cytotoxicity KW - Cysteine KW - Dactinomycin KW - contact dermatitis KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Heme-oxygenase+1+Gene+Expression+is+a+Marker+for+Hexavalent+Chromium-Induced+Stress+and+Toxicity+in+Human+Dermal+Fibroblasts&rft.au=Joseph%2C+Pius%3BHe%2C+Quanren%3BUmbright%2C+Christina&rft.aulast=Joseph&rft.aufirst=Pius&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - MAP kinase; Contact dermatitis; Antioxidants; Skin; Chromium; Glutathione; Stress; Heme oxygenase (decyclizing); Toxicity; Fibroblasts; mRNA; Gene expression; Cytotoxicity; Dactinomycin; Cysteine; contact dermatitis; Occupational exposure ER - TY - JOUR T1 - Postlicensure Monitoring of Intussusception After RotaTeq Vaccination in the United States, February 1, 2006, to September 25, 2007 AN - 19806125; 8304213 AB - BACKGROUND. In 1999, a previous rotavirus vaccine (RotaShield; Wyeth Laboratories, Marietta, PA) was withdrawn from the US market after postlicensure monitoring identified an association with intussusception. Although the new rotavirus vaccine (RotaTeq; Merck, West Point, PA) introduced in 2006 was not associated with intussusception in prelicensure trials, additional monitoring is important to ensure a complete safety profile. METHODS. We assessed intussusception reports after RotaTeq vaccination by using data from the Vaccine Adverse Event Reporting System and the Vaccine Safety Datalink, a cohort of children enrolled in managed care. Observed versus expected rate ratios were determined by using vaccine dose distribution data and Vaccine Safety Datalink background intussusception rates. RESULTS. Between February 1, 2006, and September 25, 2007, the Vaccine Adverse Event Reporting System received 160 intussusception reports after RotaTeq vaccination. With the assumptions that reporting completeness was 75% and that 75% of the distributed doses of RotaTeq were administered, the observed versus expected rate ratios were 0.53 and 0.91 for the 1-21 and 1-7 day interval after vaccination, respectively. In the Vaccine Safety Datalink, 3 intussusception cases occurred within 30 days after 111521 RotaTeq vaccinations, compared with 6 cases after 186722 non-RotaTeq vaccinations during the same period. If, like RotaShield, RotaTeq had a 37-fold increased risk of intussusception within 3 to 7 days after vaccination, then 8 intussusception cases would be expected within 3 to 7 days among the 684000 infants vaccinated with the first dose of RotaTeq in the Vaccine Safety Datalink (N = 49902) and the prelicensure trial (N = 34035) combined, whereas no cases have been observed. CONCLUSIONS. Available data do not indicate that RotaTeq is associated with intussusception. Although an intussusception risk similar in magnitude to that of RotaShield can be excluded, continued monitoring is necessary for complete assessment of the safety profile of RotaTeq. JF - Pediatrics AU - Haber, Penina AU - Patel, Manish AU - Izurieta, Hector S AU - Baggs, James AU - Gargiullo, Paul AU - Weintraub, Eric AU - Cortese, Margaret AU - Braun, MMiles AU - Belongia, Edward A AU - Miller, Elaine AU - Ball, Robert AU - Iskander, John AU - Parashar, Umesh D AD - Immunization Safety Office, Office of the Chief Science Officer. National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Marshfield Clinic Research Foundation, Epidemiology Research Center, Marshfield, Wisconsin Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1206 EP - 1212 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 6 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Rotavirus KW - vaccines KW - Data processing KW - Children KW - Vaccination KW - USA KW - Combined vaccines KW - intussusception KW - Vaccines KW - Side effects KW - Infants KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Postlicensure+Monitoring+of+Intussusception+After+RotaTeq+Vaccination+in+the+United+States%2C+February+1%2C+2006%2C+to+September+25%2C+2007&rft.au=Haber%2C+Penina%3BPatel%2C+Manish%3BIzurieta%2C+Hector+S%3BBaggs%2C+James%3BGargiullo%2C+Paul%3BWeintraub%2C+Eric%3BCortese%2C+Margaret%3BBraun%2C+MMiles%3BBelongia%2C+Edward+A%3BMiller%2C+Elaine%3BBall%2C+Robert%3BIskander%2C+John%3BParashar%2C+Umesh+D&rft.aulast=Haber&rft.aufirst=Penina&rft.date=2008-06-01&rft.volume=121&rft.issue=6&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Combined vaccines; intussusception; Vaccines; Children; Vaccination; Infants; vaccines; Side effects; Rotavirus; USA ER - TY - JOUR T1 - Synthesis and potency of novel uracil nucleotides and derivatives as P2Y sub(2) and P2Y sub(6) receptor agonists AN - 19725287; 8808036 AB - The phosphate, uracil, and ribose moieties of uracil nucleotides were varied structurally for evaluation of agonist activity at the human P2Y sub(2), P2Y sub(4), and P2Y sub(6) receptors. The 2-thio modification, found previously to enhance P2Y sub(2) receptor potency, could be combined with other favorable modifications to produce novel molecules that exhibit high potencies and receptor selectivities. Phosphonomethylene bridges introduced for stability in analogues of UDP, UTP, and uracil dinucleotides markedly reduced potency. Truncation of dinucleotide agonists of the P2Y sub(2) receptor, in the form of Up sub(4)-sugars, indicated that a terminal uracil ring is not essential for moderate potency at this receptor and that specific SAR patterns are observed at this distal end of the molecule. Key compounds reported in this study include 9, alpha , beta -methylene-UDP, a P2Y sub(6) receptor agonist; 30, Up sub(4)- phenyl ester and 34, Up sub(4)-[1]glucose, selective P2Y sub(2) receptor agonists; dihalomethylene phosphonate analogues 16 and 41, selective P2Y sub(2) receptor agonists; 43, the 2-thio analogue of INS37217 (P super(1)- (uridine-5')-P super(4)-(2'-deoxycytidine-5')tetraphosphate), a potent and selective P2Y sub(2) receptor agonist. JF - Bioorganic and Medicinal Chemistry AU - Ko, Hyojin AU - Carter, Rhonda L AU - Cosyn, Liesbet AU - Petrelli, Riccardo AU - De Castro, Sonia AU - Besada, Pedro AU - Zhou, Yixing AU - Cappellacci, Loredana AU - Franchetti, Palmarisa AU - Grifantini, Mario AU - Van Calenbergh, Serge AU - Harden, TKendall AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-0810, USA, kajacobs@helix.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 6319 EP - 6332 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 12 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - phosphonates KW - Phosphate KW - Uracil KW - Purine P2Y receptors KW - Ribose KW - Esters KW - Nucleotides KW - N 14840:Antisense, Nucleotide Analogs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+potency+of+novel+uracil+nucleotides+and+derivatives+as+P2Y+sub%282%29+and+P2Y+sub%286%29+receptor+agonists&rft.au=Ko%2C+Hyojin%3BCarter%2C+Rhonda+L%3BCosyn%2C+Liesbet%3BPetrelli%2C+Riccardo%3BDe+Castro%2C+Sonia%3BBesada%2C+Pedro%3BZhou%2C+Yixing%3BCappellacci%2C+Loredana%3BFranchetti%2C+Palmarisa%3BGrifantini%2C+Mario%3BVan+Calenbergh%2C+Serge%3BHarden%2C+TKendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ko&rft.aufirst=Hyojin&rft.date=2008-06-01&rft.volume=16&rft.issue=12&rft.spage=6319&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - phosphonates; Phosphate; Uracil; Ribose; Purine P2Y receptors; Esters; Nucleotides DO - http://dx.doi.org/10.1016/j.bmc.2008.05.013 ER - TY - JOUR T1 - Effectiveness of Local Exhaust Ventilation (LEV) in Controlling Engineered Nanomaterial Emissions During Reactor Cleanout Operations AN - 19581186; 8502066 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Old, Leo AU - Methner, Mark M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - D63 EP - D69 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 6 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Occupational exposure KW - nanotechnology KW - Exhaust emissions KW - Nanotechnology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Effectiveness+of+Local+Exhaust+Ventilation+%28LEV%29+in+Controlling+Engineered+Nanomaterial+Emissions+During+Reactor+Cleanout+Operations&rft.au=Old%2C+Leo%3BMethner%2C+Mark+M&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=D63&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802059393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ventilation; Occupational exposure; Nanotechnology; Exhaust emissions; nanotechnology DO - http://dx.doi.org/10.1080/15459620802059393 ER - TY - JOUR T1 - A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine AN - 19580976; 8520611 AB - Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in causing these abnormalities. To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation. Methods and Findings Microarray analysis followed by quantitative real-time reverse transcription PCR was used to screen cocaine-responsive and cell cycle-related genes in a neural progenitor cell line where cocaine exposure caused a robust anti-proliferative effect by interfering with the G1-to-S transition. Cyclin A2, among genes related to the G1-to-S cell cycle transition, was most strongly down-regulated by cocaine. Down-regulation of cyclin A was also found in cocaine-treated human primary neural and A2B5+ progenitor cells, as well as in rat fetal brains exposed to cocaine in utero. Reversing cyclin A down-regulation by gene transfer counteracted the proliferation inhibition caused by cocaine. Further, we found that cocaine-induced accumulation of reactive oxygen species, which involves N-oxidation of cocaine via cytochrome P450, promotes cyclin A down-regulation by causing an endoplasmic reticulum (ER) stress response, as indicated by increased phosphorylation of eIF2a and expression of ATF4. In the developing rat brain, the P450 inhibitor cimetidine counteracted cocaine-induced inhibition of neural progenitor cell proliferation as well as down-regulation of cyclin A. Conclusions Our results demonstrate that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors. The down-regulation of cyclin A is initiated by N-oxidative metabolism of cocaine and consequent ER stress. Inhibition of cocaine N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development. Investigating the mechanism of cocaine's effect on fetal brain development, Chun-Ting Lee and colleagues find that down-regulation of cyclin A by a cocaine metabolite inhibits neural proliferation. Editors' Summary Background. Every year, cocaine abuse by mothers during pregnancy exposes thousands of unborn infants (fetuses) to this powerful and addictive stimulant. Maternal cocaine abuse during early pregnancy increases the risk of miscarriage; its use during late pregnancy slows the baby's growth and can trigger premature labor. Babies exposed to cocaine shortly before birth are often irritable and have disturbed sleep patterns. They can also be very sensitive to sound and touch and consequently hard to comfort. These problems usually resolve spontaneously within the first few weeks of life but some permanent birth defects are also associated with frequent cocaine abuse during pregnancy. In particular, babies exposed to cocaine before birth sometimes have small heads-an abnormality that generally indicates a small brain-and, although they usually have normal intelligence, the development of their thinking skills and language is often delayed, and they can have behavioral problems. JF - PLOS Medicine AU - Lee, Chun-Ting AU - Chen, Jia AU - Hayashi, Teruo AU - Tsai, Shang-Yi AU - Sanchez, Joseph F AU - Errico, Stacie L AU - Amable, Rose AU - Su, Tsung-Ping AU - Lowe, Ross H AU - Huestis, Marilyn A AU - Shen, James AU - Becker, Kevin G AU - Geller, Herbert M AU - Freed, William J AU - Graeber, Manuel AD - Cellular Neurobiology Research Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Baltimore, Maryland, United States of America Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 5 IS - 6 SN - 1549-1277, 1549-1277 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Prenatal experience KW - Abortion KW - Cell cycle KW - Metabolites KW - Drug abuse KW - Reverse transcription KW - Expression vectors KW - Endoplasmic reticulum KW - Reactive oxygen species KW - Sound KW - Cocaine KW - Neural stem cells KW - Cimetidine KW - Cyclins KW - Brain KW - Stress KW - Toxicity KW - Fetuses KW - Pregnancy KW - Cyclin A KW - Cell division KW - Neurons KW - Tactile stimuli KW - Initiation factor eIF-2 KW - Cytochrome P450 KW - Cell proliferation KW - Side effects KW - Metabolism KW - Infants KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=A+Mechanism+for+the+Inhibition+of+Neural+Progenitor+Cell+Proliferation+by+Cocaine&rft.au=Lee%2C+Chun-Ting%3BChen%2C+Jia%3BHayashi%2C+Teruo%3BTsai%2C+Shang-Yi%3BSanchez%2C+Joseph+F%3BErrico%2C+Stacie+L%3BAmable%2C+Rose%3BSu%2C+Tsung-Ping%3BLowe%2C+Ross+H%3BHuestis%2C+Marilyn+A%3BShen%2C+James%3BBecker%2C+Kevin+G%3BGeller%2C+Herbert+M%3BFreed%2C+William+J%3BGraeber%2C+Manuel&rft.aulast=Lee&rft.aufirst=Chun-Ting&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=e117&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.0050117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Prenatal experience; Abortion; Cell cycle; Metabolites; Drug abuse; Reverse transcription; Expression vectors; Endoplasmic reticulum; Reactive oxygen species; Sound; Cocaine; Cimetidine; Neural stem cells; Cyclins; Brain; Stress; Toxicity; Fetuses; Pregnancy; Cyclin A; Cell division; Neurons; Tactile stimuli; Cytochrome P450; Initiation factor eIF-2; Cell proliferation; Metabolism; Side effects; Infants DO - http://dx.doi.org/10.1371/journal.pmed.0050117 ER - TY - JOUR T1 - Mental Health Outcomes in Police Personnel After Hurricane Katrina AN - 19531794; 8352329 AB - Objective: We examined symptoms of depression and posttraumatic stress disorder (PTSD) among New Orleans Police Department (NOPD) personnel who provided law enforcement and relief services to affected communities following Hurricane Katrina. Methods: We conducted a cross-sectional survey of mental health outcomes related to personal and work-related exposures of police personnel 8 weeks after the Hurricane. Results: Of the 912 police personnel who completed the questionnaire, 227 (26%) reported symptoms consistent with depression and 170 (19%) reported symptoms consistent with PTSD. Risk factors associated with PTSD include recovery of bodies, crowd control, assault, and injury to a family member. Depressive symptoms were associated with rare family contact, uninhabitable home, isolation from the NOPD, assault, and injury to a family member. Conclusions: Police personnel reported symptoms of PTSD and depression associated with work-related and personal factors following Hurricane Katrina. JF - Journal of Occupational and Environmental Medicine AU - West, C AU - Bernard, B AU - Mueller, C AU - Kitt, M AU - Driscoll, R AU - Tak, S AD - CDC/NIOSH/DSHEFS, 4676 Columbia Parkway R-10, Cincinnati, OH 45226, USA, cawest@cdc.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 689 EP - 695 VL - 50 IS - 6 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Psychology KW - police KW - law enforcement KW - posttraumatic stress disorder KW - Disasters KW - depression KW - USA, Louisiana, New Orleans KW - Hurricanes KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Mental+Health+Outcomes+in+Police+Personnel+After+Hurricane+Katrina&rft.au=West%2C+C%3BBernard%2C+B%3BMueller%2C+C%3BKitt%2C+M%3BDriscoll%2C+R%3BTak%2C+S&rft.aulast=West&rft.aufirst=C&rft.date=2008-06-01&rft.volume=50&rft.issue=6&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181638685 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Louisiana, New Orleans; police; Occupational health; Disasters; Hurricanes; posttraumatic stress disorder; depression; Injuries; Psychology; law enforcement DO - http://dx.doi.org/10.1097/JOM.0b013e3181638685 ER - TY - JOUR T1 - Assessment of Stromal-Derived Inducing Activity in the Generation of Dopaminergic Neurons from Human Embryonic Stem Cells AN - 19477851; 8305126 AB - Producing dopaminergic (DA) neurons is a major goal of human embryonic stem cell (hESC) research. DA neurons can be differentiated from hESC by coculture with the mouse PA6 stromal cell line; this differentiation-inducing effect is termed stromal-derived inducing activity (SDIA). The molecular and biochemical nature of SDIA is, however, unknown. Various studies have suggested that SDIA involves either a fixation-resistant component located on the PA6 cell surface or factors secreted into the medium by PA6 cells. To address this question, hESC were cocultured with PA6 cells for 12 days and then further differentiated with sonic hedgehog homolog, fibroblast growth factor-8, and glial cell line-derived neurotrophic factor. After 18 days, 34% of cells were tyrosine hydroxylase (TH)+. When PA6 cells were fixed or irradiated, the number of TH+ cells was decreased by threefold, whereas mitomycin-c treatment of feeder cells decreased the number of TH+ cells by 32%. The neural-inducing effect of PA6 cells, as monitored by beta -III-tubulin expression, was minimally affected by mitomycin-c treatment or fixation but was decreased 50% by irradiation. Medium conditioned by PA6 cells was ineffective in differentiating TH+ cells when used alone. Conditioned medium combined with heparin and/or fixed PA6 cells produced TH+ cell differentiation, although less effectively than PA6 cell coculture. Thus, PA6 cell surface activity is required for neural differentiation of hESC, but secreted factors are required for the specific DA neuron-inducing effect. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Vazin, Tandis AU - Chen, Jia AU - Lee, Chun-Ting AU - Amable, Rose AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1517 EP - 1525 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 6 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cell surface KW - stromal cells KW - Glial cell line-derived neurotrophic factor KW - Cell culture KW - Mitomycin C KW - Differentiation KW - Neurogenesis KW - Stem cells KW - Hedgehog protein KW - Dopamine KW - Radiation KW - Embryo cells KW - Neurons KW - Tyrosine 3-monooxygenase KW - Heparin KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessment+of+Stromal-Derived+Inducing+Activity+in+the+Generation+of+Dopaminergic+Neurons+from+Human+Embryonic+Stem+Cells&rft.au=Vazin%2C+Tandis%3BChen%2C+Jia%3BLee%2C+Chun-Ting%3BAmable%2C+Rose%3BFreed%2C+William+J&rft.aulast=Vazin&rft.aufirst=Tandis&rft.date=2008-06-01&rft.volume=26&rft.issue=6&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; stromal cells; Glial cell line-derived neurotrophic factor; Cell culture; Mitomycin C; Differentiation; Hedgehog protein; Stem cells; Neurogenesis; Dopamine; Embryo cells; Radiation; Neurons; Tyrosine 3-monooxygenase; Heparin ER - TY - JOUR T1 - General and plastic surgery devices; reclassification of the tissue adhesive for topical approximation of skin device. Final rule. AN - 69293718; 18605409 AB - The Food and Drug Administration (FDA) is reclassifying the device type, tissue adhesive for the topical approximation of skin, from class III (premarket approval) into class II (special controls). Tissue adhesives for non-topical uses remain in class III and continue to require premarket approval applications (PMAs). FDA is proposing this reclassification in accordance with the Federal Food, Drug, and Cosmetic Act (the act). Elsewhere in this issue of the Federal Register, FDA is announcing the availability of a guidance document entitled "Class II Special Controls Guidance Document: Tissue Adhesive for the Topical Approximation of Skin" that will serve as the special control for the reclassified device type. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/05/30/ PY - 2008 DA - 2008 May 30 SP - 31027 EP - 31033 VL - 73 IS - 105 SN - 0097-6326, 0097-6326 KW - Tissue Adhesives KW - 0 KW - Health technology assessment KW - United States KW - Equipment Safety -- classification KW - United States Food and Drug Administration KW - Reconstructive Surgical Procedures -- instrumentation KW - Reconstructive Surgical Procedures -- legislation & jurisprudence KW - Humans KW - Device Approval -- legislation & jurisprudence KW - Legislation, Drug KW - Administration, Topical KW - Tissue Adhesives -- adverse effects KW - Tissue Adhesives -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69293718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=General+and+plastic+surgery+devices%3B+reclassification+of+the+tissue+adhesive+for+topical+approximation+of+skin+device.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-05-30&rft.volume=73&rft.issue=105&rft.spage=31027&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine causes microglial activation in the brains of human abusers. AN - 70785194; 18509037 AB - Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms in the brain. Although reactive microgliosis has been observed in animal models of methamphetamine neurotoxicity, no study has reported on the status of microglial activation in human methamphetamine abusers. The present study reports on 12 abstinent methamphetamine abusers and 12 age-, gender-, and education-matched control subjects who underwent positron emission tomography using a radiotracer for activated microglia, [(11)C](R)-(1-[2-chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide) ([(11)C](R)-PK11195). Compartment analysis was used to estimate quantitative levels of binding potentials of [(11)C](R)-PK11195 in brain regions with dopaminergic and/or serotonergic innervation. The mean levels of [(11)C](R)-PK11195 binding were higher in methamphetamine abusers than those in control subjects in all brain regions (>250% higher; p < 0.01 for all). In addition, the binding levels in the midbrain, striatum, thalamus, and orbitofrontal and insular cortices (p < 0.05) correlated inversely with the duration of methamphetamine abstinence. These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Sekine, Yoshimoto AU - Ouchi, Yasuomi AU - Sugihara, Genichi AU - Takei, Nori AU - Yoshikawa, Etsuji AU - Nakamura, Kazuhiko AU - Iwata, Yasuhide AU - Tsuchiya, Kenji J AU - Suda, Shiro AU - Suzuki, Katsuaki AU - Kawai, Masayoshi AU - Takebayashi, Kiyokazu AU - Yamamoto, Shigeyuki AU - Matsuzaki, Hideo AU - Ueki, Takatoshi AU - Mori, Norio AU - Gold, Mark S AU - Cadet, Jean L AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 SP - 5756 EP - 5761 VL - 28 IS - 22 KW - Antineoplastic Agents KW - 0 KW - Carbon Isotopes KW - Central Nervous System Stimulants KW - Isoquinolines KW - Methamphetamine KW - 44RAL3456C KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Positron-Emission Tomography -- methods KW - Isoquinolines -- pharmacokinetics KW - Protein Binding -- drug effects KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Adult KW - Case-Control Studies KW - Carbon Isotopes -- pharmacokinetics KW - Male KW - Female KW - Methamphetamine -- adverse effects KW - Brain -- pathology KW - Microglia -- diagnostic imaging KW - Amphetamine-Related Disorders -- pathology KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Central Nervous System Stimulants -- adverse effects KW - Amphetamine-Related Disorders -- etiology KW - Microglia -- drug effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Methamphetamine+causes+microglial+activation+in+the+brains+of+human+abusers.&rft.au=Sekine%2C+Yoshimoto%3BOuchi%2C+Yasuomi%3BSugihara%2C+Genichi%3BTakei%2C+Nori%3BYoshikawa%2C+Etsuji%3BNakamura%2C+Kazuhiko%3BIwata%2C+Yasuhide%3BTsuchiya%2C+Kenji+J%3BSuda%2C+Shiro%3BSuzuki%2C+Katsuaki%3BKawai%2C+Masayoshi%3BTakebayashi%2C+Kiyokazu%3BYamamoto%2C+Shigeyuki%3BMatsuzaki%2C+Hideo%3BUeki%2C+Takatoshi%3BMori%2C+Norio%3BGold%2C+Mark+S%3BCadet%2C+Jean+L&rft.aulast=Sekine&rft.aufirst=Yoshimoto&rft.date=2008-05-28&rft.volume=28&rft.issue=22&rft.spage=5756&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1179-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2004 Jun;89(6):1445-53 [15189347] Arch Gen Psychiatry. 2004 Jan;61(1):73-84 [14706946] Neurosci Lett. 2004 Sep 9;367(3):349-54 [15337264] J Pharmacol Exp Ther. 2004 Oct;311(1):1-7 [15163680] Brain Res. 1992 Aug 7;587(2):250-6 [1381982] J Pers Soc Psychol. 1992 Sep;63(3):452-9 [1403624] Radiology. 1993 Jan;186(1):59-65 [8416587] J Cereb Blood Flow Metab. 1996 Jan;16(1):42-52 [8530554] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Nature. 1997 Apr 24;386(6627):827-30 [9126740] Mol Neurobiol. 1997 Dec;15(3):307-39 [9457704] J Immunol. 1998 Feb 15;160(4):1944-8 [9469457] Lancet. 1998 Oct 31;352(9138):1433-7 [9807990] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] Ann Neurol. 2005 Feb;57(2):168-75 [15668962] J Neurochem. 2005 Feb;92(4):790-7 [15686480] Eur Neuropsychopharmacol. 2002 Dec;12(6):581-6 [12468021] Neuroimage. 2003 Jul;19(3):1085-94 [12880834] Am J Psychiatry. 2003 Sep;160(9):1699-701 [12944350] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Neurosci Lett. 2003 Nov 27;352(1):13-6 [14615038] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Psychoactive Drugs. 2000 Apr-Jun;32(2):137-41 [10908000] Biomed Chromatogr. 2000 Aug;14(5):293-300 [10960827] Brain. 2000 Nov;123 ( Pt 11):2321-37 [11050032] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Exp Neurol. 2001 Jun;169(2):219-30 [11358437] Am J Psychiatry. 2001 Aug;158(8):1206-14 [11481152] Lancet. 2001 Aug 11;358(9280):461-7 [11513911] Neuropsychopharmacology. 2002 Jan;26(1):53-63 [11751032] J Subst Abuse Treat. 2002 Sep;23(2):151-6 [12220613] Glia. 2002 Nov;40(2):206-17 [12379908] Mol Pharmacol. 2002 Nov;62(5):993-1000 [12391261] Exp Neurol. 2004 May;187(1):47-57 [15081587] Neuropsychopharmacology. 2004 May;29(5):1019-26 [15039764] Neuroimage. 2005 Jun;26(2):480-92 [15907305] Brain Res. 2005 Jul 19;1050(1-2):190-8 [15987631] Folia Neuropathol. 2005;43(2):81-9 [16012909] J Pharmacol Exp Ther. 2005 Nov;315(2):658-67 [16076935] Neurotox Res. 2005 Nov;8(3-4):199-206 [16371314] Arch Gen Psychiatry. 2006 Jan;63(1):90-100 [16389202] Eur J Pharmacol. 2006 Aug 21;544(1-3):1-9 [16859675] Biol Psychiatry. 2007 Mar 1;61(5):577-81 [16712806] CNS Neurol Disord Drug Targets. 2007 Jun;6(3):219-33 [17511618] J Neurosci. 2004 Jun 30;24(26):6028-36 [15229250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.1179-08.2008 ER - TY - CPAPER T1 - Skeletal Muscle Morphology Following Chronic Stretch-Shortening Contraction Exposure: Effects of Glutathione Depletion and Age T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40929015; 4850950 JF - 55th Annual Meeting on American College of Sports Medicine AU - Baker, Brent A AU - Hollander, Melinda S AU - Kashon, Michael L AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Skeletal muscle KW - Muscle contraction KW - Morphology KW - Age KW - Glutathione KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Skeletal+Muscle+Morphology+Following+Chronic+Stretch-Shortening+Contraction+Exposure%3A+Effects+of+Glutathione+Depletion+and+Age&rft.au=Baker%2C+Brent+A%3BHollander%2C+Melinda+S%3BKashon%2C+Michael+L%3BCutlip%2C+Robert+G&rft.aulast=Baker&rft.aufirst=Brent&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relation between OMNI-RPE and Heart Rate Wearing Running Clothes VS. Firefighter Ensembles during Treadmill Exercise T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40924644; 4851710 JF - 55th Annual Meeting on American College of Sports Medicine AU - Coca, Aitor AU - Sinkule, Edward J AU - Powell, Jeffrey B AU - Roberge, Raymond J AU - Williams, W Jon Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Firefighter services KW - Heart rate KW - Running KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40924644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Relation+between+OMNI-RPE+and+Heart+Rate+Wearing+Running+Clothes+VS.+Firefighter+Ensembles+during+Treadmill+Exercise&rft.au=Coca%2C+Aitor%3BSinkule%2C+Edward+J%3BPowell%2C+Jeffrey+B%3BRoberge%2C+Raymond+J%3BWilliams%2C+W+Jon&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Glutathione Depletion on Real-Time Muscle Performance during a Chronic Exposure of Stretch-Shortening Contractions: Age Effects T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40923212; 4851094 JF - 55th Annual Meeting on American College of Sports Medicine AU - Hollander, Melinda S AU - Baker, Brent A AU - Ensey, James AU - Kashon, Michael L AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Muscle contraction KW - Age KW - Glutathione KW - Chronic exposure KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40923212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Effects+of+Glutathione+Depletion+on+Real-Time+Muscle+Performance+during+a+Chronic+Exposure+of+Stretch-Shortening+Contractions%3A+Age+Effects&rft.au=Hollander%2C+Melinda+S%3BBaker%2C+Brent+A%3BEnsey%2C+James%3BKashon%2C+Michael+L%3BCutlip%2C+Robert+G&rft.aulast=Hollander&rft.aufirst=Melinda&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Glutathione and Age on Muscle Performance during a Chronic Exposure of Stretch-Shortening Contractions T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40922699; 4850949 JF - 55th Annual Meeting on American College of Sports Medicine AU - Cutlip, Robert G AU - Baker, Brent A AU - Hollander, Melinda S AU - Ensey, James S AU - Kashon, Michael L Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Muscle contraction KW - Age KW - Glutathione KW - Chronic exposure KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Effects+of+Glutathione+and+Age+on+Muscle+Performance+during+a+Chronic+Exposure+of+Stretch-Shortening+Contractions&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BHollander%2C+Melinda+S%3BEnsey%2C+James+S%3BKashon%2C+Michael+L&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Response of Tibialis Anterior Tendon to a Chronic Exposure of Stretch-Shortening Cycles: Age Effects T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40922569; 4850686 JF - 55th Annual Meeting on American College of Sports Medicine AU - Ensey, James S AU - Hollander, Melinda S AU - Wu, John Z AU - Kashon, Michael L AU - Baker, Brent A AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Age KW - Tendons KW - Chronic exposure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Response+of+Tibialis+Anterior+Tendon+to+a+Chronic+Exposure+of+Stretch-Shortening+Cycles%3A+Age+Effects&rft.au=Ensey%2C+James+S%3BHollander%2C+Melinda+S%3BWu%2C+John+Z%3BKashon%2C+Michael+L%3BBaker%2C+Brent+A%3BCutlip%2C+Robert+G&rft.aulast=Ensey&rft.aufirst=James&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of the Climate Change on the Autumn Phytoplankton from the Gulf of Riga T2 - Third US-EU-Baltic International Symposium on Ocean Observations, Ecosystem-Based Management and Forecasting AN - 40911095; 4843375 JF - Third US-EU-Baltic International Symposium on Ocean Observations, Ecosystem-Based Management and Forecasting AU - Purvina, Santa AU - Purina, Ingrida AU - Barda, Ieva AU - Strode, Evita AU - Putna, Ieva AU - Yurkovska, Vija AU - Pfeifere, Mara AU - Balode, Maija Y1 - 2008/05/27/ PY - 2008 DA - 2008 May 27 KW - Baltic Sea, Riga Gulf KW - Phytoplankton KW - Climatic changes KW - Ecosystem disturbance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+US-EU-Baltic+International+Symposium+on+Ocean+Observations%2C+Ecosystem-Based+Management+and+Forecasting&rft.atitle=The+Impact+of+the+Climate+Change+on+the+Autumn+Phytoplankton+from+the+Gulf+of+Riga&rft.au=Purvina%2C+Santa%3BPurina%2C+Ingrida%3BBarda%2C+Ieva%3BStrode%2C+Evita%3BPutna%2C+Ieva%3BYurkovska%2C+Vija%3BPfeifere%2C+Mara%3BBalode%2C+Maija&rft.aulast=Purvina&rft.aufirst=Santa&rft.date=2008-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+US-EU-Baltic+International+Symposium+on+Ocean+Observations%2C+Ecosystem-Based+Management+and+Forecasting&rft.issn=&rft_id=info:doi/ L2 - http://www.us-eu-baltic2008.org/glance.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatography. AN - 69194647; 18471487 AB - Previously, a method was presented for the analysis of mechlorethamine by derivatization of this unstable nitrogen mustard to bis(2-phenylthioethyl)methylamine (PTEMA), a stable compound suitable for analysis by HPLC with UV detection [J.C. Reepmeyer, J. Chromatogr. A, 1085 (2005) 262]. Mechlorethamine HCl served as a reference standard and it was derivatized in situ simultaneously with samples of mechlorethamine HCl in ointment preparations. This paper presents the synthesis of PTEMA on a gram scale, synthesis of its picrate salt, bis(2-phenylthioethyl)methylamine picrate (PTEMAP), and isolation of the picrate as a crystalline solid. PTEMAP may serve as a reference standard replacing the toxic mechlorethamine HCl. Insights into the handling, storage, drying, and hygroscopic properties of mechlorethamine HCl and PTEMAP are discussed. In addition, one step following the derivatization procedure in the original method is recognized as a potential for error, and a procedure relating to the order of addition of reagents is presented to avoid this error. The method has been extended to the analysis of mechlorethamine in aqueous solutions. JF - Analytica chimica acta AU - Reepmeyer, John C AU - Ye, Wei AU - Ritschel, Wolfgang A AD - United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA. john.reepmeyer@fda.hhs.gov Y1 - 2008/05/26/ PY - 2008 DA - 2008 May 26 SP - 78 EP - 84 VL - 616 IS - 1 KW - Diethylamines KW - 0 KW - Solutions KW - Sulfides KW - bis(2-phenylthioethyl)methylamine KW - Water KW - 059QF0KO0R KW - Mechlorethamine KW - 50D9XSG0VR KW - Index Medicus KW - Sensitivity and Specificity KW - Molecular Structure KW - Chromatography, High Pressure Liquid -- standards KW - Water -- chemistry KW - Chromatography, High Pressure Liquid -- methods KW - Solutions -- chemistry KW - Sulfides -- chemical synthesis KW - Mechlorethamine -- standards KW - Mechlorethamine -- analysis KW - Diethylamines -- analysis KW - Sulfides -- analysis KW - Diethylamines -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69194647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Modifications+and+insights+into+a+method+for+the+analysis+of+the+nitrogen+mustard+mechlorethamine+by+high-performance+liquid+chromatography.&rft.au=Reepmeyer%2C+John+C%3BYe%2C+Wei%3BRitschel%2C+Wolfgang+A&rft.aulast=Reepmeyer&rft.aufirst=John&rft.date=2008-05-26&rft.volume=616&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2008.04.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-10 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.aca.2008.04.020 ER - TY - JOUR T1 - Analysis of tetramethylene disulfotetramine in foods using solid-phase microextraction-gas chromatography-mass spectrometry. AN - 69152553; 18378250 AB - An automated solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) method for the determination of tetramethylene disulfotetramine in foods was developed. A comparison of direct immersion (DI) and headspace (HS) extraction techniques using a 70microm carbowax/divinylbenzene (CW/DVB) fiber is presented. The optimized DI-SPME method provided an aqueous extraction limit of detection (LOD) of 9.0ng/g while the HS-SPME LOD was 2.7ng/g. In both SPME modes, recovery was highly matrix dependent and quantification requires standard addition calibrations. Analysis of foods using DI-SPME encountered many obstacles including fiber fouling, low recovery and poor reproducibility. HS-SPME was successfully applied to food analysis with minimal interferences. Standard addition calibration curves for foods gave high linearity (R2>0.98), reproducibility (RSD<12%) and sensitivity with LODs ranging from 0.9 to 4.3ng/g. JF - Journal of chromatography. A AU - De Jager, Lowri S AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, USA. lowri.dejager@fda.hhs.gov Y1 - 2008/05/23/ PY - 2008 DA - 2008 May 23 SP - 36 EP - 40 VL - 1192 IS - 1 SN - 0021-9673, 0021-9673 KW - Bridged-Ring Compounds KW - 0 KW - tetramethylenedisulfotetramine KW - F6TS3WME05 KW - Index Medicus KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Food Contamination -- analysis KW - Solid Phase Microextraction -- methods KW - Bridged-Ring Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69152553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Analysis+of+tetramethylene+disulfotetramine+in+foods+using+solid-phase+microextraction-gas+chromatography-mass+spectrometry.&rft.au=De+Jager%2C+Lowri+S%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=De+Jager&rft.aufirst=Lowri&rft.date=2008-05-23&rft.volume=1192&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2008.03.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chroma.2008.03.042 ER - TY - CPAPER T1 - Can Disproportionality Analysis Play a Role in Monitoring Drug-Eluting Stent Safety? T2 - 16th World Congress of Cardiology (WCC 2008) AN - 41052018; 4905472 DE: JF - 16th World Congress of Cardiology (WCC 2008) AU - Duggirala, H AU - Yang, X AU - Van Manen, R. Y1 - 2008/05/18/ PY - 2008 DA - 2008 May 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41052018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+World+Congress+of+Cardiology+%28WCC+2008%29&rft.atitle=Can+Disproportionality+Analysis+Play+a+Role+in+Monitoring+Drug-Eluting+Stent+Safety%3F&rft.au=Duggirala%2C+H%3BYang%2C+X%3BVan+Manen%2C+R.&rft.aulast=Duggirala&rft.aufirst=H&rft.date=2008-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+World+Congress+of+Cardiology+%28WCC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://circ.ahajournals.org/cgi/reprint/CIRCULATIONAHA.108.189875 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993-2003 AN - 19583164; 8509145 AB - Exposure to certain environmental toxicants may be associated with increased risk of developing diabetes. The authors' aim was to investigate the relation between lifetime exposure to specific agricultural pesticides and diabetes incidence among pesticide applicators. The study included 33,457 licensed applicators, predominantly non-Hispanic White males, enrolled in the Agricultural Health Study. Incident diabetes was self-reported in a 5-year follow-up interview (1999-2003), giving 1,176 diabetics and 30,611 nondiabetics for analysis. Lifetime exposure to pesticides and covariate information were reported by participants at enrollment (1993-1997). Using logistic regression, the authors considered two primary measures of pesticide exposure: ever use and cumulative lifetime days of use. They found seven specific pesticides (aldrin, chlordane, heptachlor, dichlorvos, trichlorfon, alachlor, and cyanazine) for which the odds of diabetes incidence increased with both ever use and cumulative days of use. Applicators who had used the organochlorine insecticides aldrin, chlordane, and heptachlor more than 100 lifetime days had 51%, 63%, and 94% increased odds of diabetes, respectively. The observed association of organochlorine and organophosphate insecticides with diabetes is consistent with results from previous human and animal studies. Long-term exposure from handling certain pesticides, in particular, organochlorine and organophosphate insecticides, may be associated with increased risk of diabetes. JF - American Journal of Epidemiology AU - Montgomery, M P AU - Kamel, F AU - Saldana, T M AU - Alavanja, MCR AU - Sandler, D P AD - 1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, sandler@niehs.nih.gov Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 1235 EP - 1246 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 167 IS - 10 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - agrochemicals KW - diabetes mellitus KW - environmental exposure KW - hydrocarbons, chlorinated KW - insecticides KW - pesticides KW - phosphoric acid esters KW - Organochlorine compounds KW - Toxicants KW - Organophosphates KW - Aldrin KW - Insecticides KW - Occupational exposure KW - Dichlorvos KW - Pesticides (organophosphorus) KW - heptachlor KW - Chlordane KW - dichlorvos KW - Alachlor KW - Herbicides KW - organophosphates KW - Diabetes mellitus KW - Heptachlor KW - Pesticides KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19583164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Incident+Diabetes+and+Pesticide+Exposure+among+Licensed+Pesticide+Applicators%3A+Agricultural+Health+Study%2C+1993-2003&rft.au=Montgomery%2C+M+P%3BKamel%2C+F%3BSaldana%2C+T+M%3BAlavanja%2C+MCR%3BSandler%2C+D+P&rft.aulast=Montgomery&rft.aufirst=M&rft.date=2008-05-15&rft.volume=167&rft.issue=10&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Pesticides (organophosphorus); Organochlorine compounds; Insecticides; Toxicants; Chlordane; heptachlor; Aldrin; Pesticides; Alachlor; organophosphates; Dichlorvos; Organophosphates; dichlorvos; Herbicides; diabetes mellitus; Heptachlor; Occupational exposure DO - http://dx.doi.org/10.1093/aje/kwn028 ER - TY - CPAPER T1 - DNp63a Modulates Keratinocyte Growth Regulation via Activation of NF-kB/c-Rel T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40954560; 4867808 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - King, K E AU - Ponnamperuma, R M AU - Allen, C AU - Chen, Z AU - Van Waes, C. AU - Weinberg, W C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - NF-B protein KW - Keratinocytes KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=DNp63a+Modulates+Keratinocyte+Growth+Regulation+via+Activation+of+NF-kB%2Fc-Rel&rft.au=King%2C+K+E%3BPonnamperuma%2C+R+M%3BAllen%2C+C%3BChen%2C+Z%3BVan+Waes%2C+C.%3BWeinberg%2C+W+C&rft.aulast=King&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automated Evaluation of HER-2/NEU Immunohistochemical Expression in Breast Cancer Using Digital Microscopy T2 - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AN - 40907965; 4846900 JF - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AU - Gavrielides, Marios AU - Masmoudi, Hela AU - Petrick, Nicholas AU - Myers, Kyle AU - Hewitt, Stephen Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Breast cancer KW - Microscopy KW - ErbB-2 protein KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40907965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.atitle=Automated+Evaluation+of+HER-2%2FNEU+Immunohistochemical+Expression+in+Breast+Cancer+Using+Digital+Microscopy&rft.au=Gavrielides%2C+Marios%3BMasmoudi%2C+Hela%3BPetrick%2C+Nicholas%3BMyers%2C+Kyle%3BHewitt%2C+Stephen&rft.aulast=Gavrielides&rft.aufirst=Marios&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomedicalimaging.org/RegularProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Equivalence of Inhaled Corticosteroids - US Perspectives T2 - 2008 Conference on Respiratory Drug Delivery (RDD 2008) AN - 40909416; 4845482 JF - 2008 Conference on Respiratory Drug Delivery (RDD 2008) AU - Chowdhury, Badrul A Y1 - 2008/05/11/ PY - 2008 DA - 2008 May 11 KW - Corticoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40909416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+on+Respiratory+Drug+Delivery+%28RDD+2008%29&rft.atitle=Therapeutic+Equivalence+of+Inhaled+Corticosteroids+-+US+Perspectives&rft.au=Chowdhury%2C+Badrul+A&rft.aulast=Chowdhury&rft.aufirst=Badrul&rft.date=2008-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+on+Respiratory+Drug+Delivery+%28RDD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.rddonline.com/rdd/rdd.php?id=3&sid=3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Persistent organochlorine pesticides and risk of testicular germ cell tumors. AN - 69184556; 18445826 AB - Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. Adjusted odds ratios (ORs) and their associated 95% confidence intervals (CIs) for the risk of TGCT overall and for the histological subgroups, seminoma and nonseminoma, were estimated using multivariable logistic regression. All statistical tests were two-sided. TGCT risk was statistically significantly associated with higher plasma levels of p,p'-DDE (for highest quartile [Q4] vs lowest quartile [Q1], OR = 1.71, 95% CI = 1.23 to 2.38, P(trend) = .0002) and of two chlordane components, cis-nonachlor (Q4 vs Q1, OR = 1.56, 95% CI = 1.11 to 2.18, P(trend) = .009) and trans-nonachlor (Q4 vs Q1, OR = 1.46, 95% CI = 1.07 to 2.00, P(trend) = .026). Seminoma risk was statistically significantly associated with p,p'-DDE (Q4 vs Q1, OR = 1.91, 95% CI = 1.22 to 2.99, P(trend) = .0008), cis-nonachlor (Q4 vs Q1, OR = 1.93, 95% CI = 1.27 to 2.93, P(trend) = .0045), trans-nonachlor (Q4 vs Q1, OR = 1.72, 95% CI = 1.11 to 2.67, P(trend) = .033), and a chlordane metabolite, oxychlordane (Q4 vs Q1, OR = 1.64, 95% CI = 1.04 to 2.60, P(trend) = .048), whereas nonseminoma risk showed a statistically significant association with p,p'-DDE only (Q4 vs Q1, OR = 1.63, 95% CI = 1.10 to 2.42, P(trend) = .0044). Increased exposure to p,p'-DDE may be associated with the risk of both seminomatous and nonseminomatous TGCTs, whereas exposure to chlordane compounds and metabolites may be associated with the risk of seminoma. Because evidence suggests that TGCT is initiated in very early life, it is possible that exposure to these persistent organic pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Weber, Jean-Philippe AU - Rubertone, Mark V AU - Erickson, Ralph L AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852-7234, USA. mcglynnk@mail.nih.gov Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 SP - 663 EP - 671 VL - 100 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Pesticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Seminoma -- chemically induced KW - Humans KW - Multivariate Analysis KW - Pregnancy KW - Breast Feeding -- adverse effects KW - Hydrocarbons, Chlorinated -- toxicity KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Male KW - Prenatal Exposure Delayed Effects KW - Neoplasms, Germ Cell and Embryonal -- ethnology KW - DDT -- toxicity KW - Testicular Neoplasms -- chemically induced KW - Environmental Exposure -- adverse effects KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Testicular Neoplasms -- ethnology KW - Neoplasms, Germ Cell and Embryonal -- chemically induced KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69184556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Persistent+organochlorine+pesticides+and+risk+of+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2008-05-07&rft.volume=100&rft.issue=9&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjn101 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-23 N1 - Date created - 2008-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djn101 ER - TY - CPAPER T1 - Vibration Exposure Induces Mechanical Hyperalgesia in Lean but Not Fatty Zucker Rats T2 - 27th Annual Scientific Meeting of the American Pain Society (APS 2008) AN - 40916040; 4850364 JF - 27th Annual Scientific Meeting of the American Pain Society (APS 2008) AU - Krajnak, K AU - Johnson, C AU - Waugh, S AU - Miller, R Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 KW - Vibration KW - Rats KW - Pain perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40916040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Scientific+Meeting+of+the+American+Pain+Society+%28APS+2008%29&rft.atitle=Vibration+Exposure+Induces+Mechanical+Hyperalgesia+in+Lean+but+Not+Fatty+Zucker+Rats&rft.au=Krajnak%2C+K%3BJohnson%2C+C%3BWaugh%2C+S%3BMiller%2C+R&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2008-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Scientific+Meeting+of+the+American+Pain+Society+%28APS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ampainsoc.org/meeting/annual_08/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats. AN - 69159233; 18407439 AB - Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity. JF - Toxicology letters AU - Cho, Wan-Seob AU - Han, Beom Seok AU - Ahn, Byeongwoo AU - Nam, Ki Taek AU - Choi, Mina AU - Oh, Sang Yeon AU - Kim, Seung Hee AU - Jeong, Jayoung AU - Jang, Dong Deuk AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea. Y1 - 2008/05/05/ PY - 2008 DA - 2008 May 05 SP - 110 EP - 116 VL - 178 IS - 2 SN - 0378-4274, 0378-4274 KW - Carcinogens KW - 0 KW - Peroxisome Proliferators KW - Phthalic Acids KW - Catalase KW - EC 1.11.1.6 KW - diisodecyl phthalate KW - WF93T741QI KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Sex Characteristics KW - Neoplasms -- epidemiology KW - Rats KW - Catalase -- metabolism KW - Rats, Inbred F344 KW - Blotting, Western KW - Body Weight -- drug effects KW - Neoplasms -- chemically induced KW - Carcinogenicity Tests KW - Immunohistochemistry KW - Female KW - Male KW - Survival Analysis KW - Organ Size -- drug effects KW - Peroxisome Proliferators -- toxicity KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69159233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Peroxisome+proliferator+di-isodecyl+phthalate+has+no+carcinogenic+potential+in+Fischer+344+rats.&rft.au=Cho%2C+Wan-Seob%3BHan%2C+Beom+Seok%3BAhn%2C+Byeongwoo%3BNam%2C+Ki+Taek%3BChoi%2C+Mina%3BOh%2C+Sang+Yeon%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung%3BJang%2C+Dong+Deuk&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2008-05-05&rft.volume=178&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Lett. 2010 Aug 16;197(2):156 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2008.02.013 ER - TY - JOUR T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine AN - 20868024; 8292046 AB - Pyrrolizidine alkaloid-containing plants are widespread in the world and may be the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolism to exert their genotoxicity and tumorigenicity. Our mechanistic studies have determined that metabolism of the retronecine-type (riddelliine, retrorsine, and monocrotaline), heliotridine-type (lasiocarpine), and otonecine-type (clivorine) tumorigenic pyrrolizidine alkaloids in vivo and/or in vitro all generates a common set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts responsible for tumor induction. All the pyrrolizidine alkaloids studied previously are diesters with an ester linkage at the C7 and C9 positions of the necine base. In this study, we report that F344 rat liver microsomal metabolism of heliotrine, a tumorigenic monoester bearing a hydroxyl group at the C7 of the necine base, resulted in the formation of the dehydroheliotridine (DHH) metabolite. When incubations of heliotrine were carried out in the presence of calf thymus DNA, the same set of DHP-derived DNA adducts was formed. These results support that DHP-derived DNA adducts are potential common biomarkers of pyrrolizidine alkaloid exposure and tumorigenicity. For comparison, the dehydroretronecine (DHR)-derived DNA adducts formed from metabolism of riddleiine, retrorsine, monocrotaline, riddelleiine N-oxide, and retrorsine N-oxide were measured in parallel; the levels of DHP-derived DNA adduct formation were in the order: riddelliine rho etrorsine>monocrotaline>retrorsine N-oxide>=riddelliine N-oxide>heliotrine. (+)S-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (-)R-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine 7-(deoxyguanosin-N super(2)-yl)DHP of 7-(deoxyguanosin-N super(2)-yl)DHP JF - Toxicology Letters AU - Xia, Q AU - Yan, J AU - Chou, M W AU - Fu, P P AD - Jefferson, AR 72079, United States, peter.fu@fda.hhs.gov Y1 - 2008/05/05/ PY - 2008 DA - 2008 May 05 SP - 77 EP - 82 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 178 IS - 2 SN - 0378-4274, 0378-4274 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Calf thymus KW - DNA adducts KW - Wildlife KW - Genotoxicity KW - N-Oxides KW - Tumorigenicity KW - retrorsine KW - Tumors KW - Esters KW - biomarkers KW - Livestock KW - pyrrolizidine alkaloids KW - Liver KW - Monocrotaline KW - Metabolic activation KW - Dehydroretronecine KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20868024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Formation+of+DHP-derived+DNA+adducts+from+metabolic+activation+of+the+prototype+heliotridine-type+pyrrolizidine+alkaloid%2C+heliotrine&rft.au=Xia%2C+Q%3BYan%2C+J%3BChou%2C+M+W%3BFu%2C+P+P&rft.aulast=Xia&rft.aufirst=Q&rft.date=2008-05-05&rft.volume=178&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Calf thymus; DNA adducts; Genotoxicity; Wildlife; N-Oxides; Tumorigenicity; retrorsine; Tumors; Esters; biomarkers; Livestock; pyrrolizidine alkaloids; Monocrotaline; Liver; Metabolic activation; Dehydroretronecine DO - http://dx.doi.org/10.1016/j.toxlet.2008.02.008 ER - TY - GEN T1 - Tribal Child Care and Development Fund: Guide for New Administrators AN - 881462028; ED519375 AB - Tribal Child Care and Development Fund administrators work each day to ensure that the children and families in tribal communities have the child care services that best meet their needs. The Child Care and Development Fund (CCDF), a federal block grant for States, Tribes, and Territories, is a key resource to help increase the availability, affordability, and quality of child care services. With Child Care and Development Funds, tribal CCDF administrators can support low-income families, families receiving temporary public assistance, and those transitioning from public assistance in obtaining child care services so they may work, attend training, or participate in educational activities. Developed from information and resources provided at national and regional tribal CCDF administrator trainings, this Guide brings together the technical and practical aspects of tribal CCDF administration. Examples of effective program strategies are provided to illustrate the various ways that tribal CCDF administrators respond to the needs of children and families served through the child care assistance program. Footnotes in each section point to sources of additional information, including guidance documents disseminated by the Child Care Bureau and specific sections of the Federal regulations that govern the CCDF program. Tribal CCDF administrators should always consult the regulations and current CCDF guidance for the most comprehensive and up-to-date information on the management of a tribal CCDF program. Appendices include: (1) Getting Started as a New Administrator; (2) Federal CCDF Contacts and Resources; (3) Sample Quality Activities; (4) Potential Collaborative Partners for Tribal CCDF Programs; and (5) Tribal CCDF Dates to Remember. (Contains 46 footnotes.) Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 34 PB - Child Care Bureau. US Department of Health and Human Services, Administration for Children & Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Elementary Secondary Education KW - Low Income Groups KW - Program Administration KW - Federal Aid KW - Family Needs KW - Administrator Guides KW - Child Care KW - Supported Employment KW - Block Grants KW - Grantsmanship KW - Tribes KW - Partnerships in Education KW - Money Management KW - Family Programs KW - Program Implementation KW - Federal Programs KW - American Indian Studies KW - Disadvantaged KW - Technical Assistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881462028?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - A regulatory perspective on the role of drug interactions in antiretroviral drug development. AN - 733326991; 19372986 AB - To provide a regulatory perspective on the role of drug interaction information in the development of antiretroviral drugs. Additionally, this review highlights novel studies that provided important information for the safe and effective use of antiretroviral medications. The management of drug interactions in HIV therapy becomes more complex with the introduction of each new drug because many antiretroviral drugs are involved in multiple metabolic and transporter-based interactions. Therefore, a comprehensive preclinical evaluation to characterize a new drug's metabolic pathway(s) followed by in-vivo studies is critical for the safe use of combination antiretroviral therapy. This review highlights published studies to illustrate several clinical and regulatory issues for in-vivo drug interaction studies such as general design issues, study-population selection, study-design options, use of historical controls and interpretation of results. Early identification of potential drug interactions can help identify and prioritize clinically important interaction studies essential to the overall development process. Understanding the clinical implications and management of drug interactions can lead to more effective long-term therapy, reduce toxicity, and delay the development of resistance. JF - Current opinion in HIV and AIDS AU - Struble, Kimberly A AU - Reynolds, Kellie Schoolar AD - Office of New Drugs, Division of Antiviral Products, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. kimberly.struble@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 325 EP - 329 VL - 3 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733326991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+HIV+and+AIDS&rft.atitle=A+regulatory+perspective+on+the+role+of+drug+interactions+in+antiretroviral+drug+development.&rft.au=Struble%2C+Kimberly+A%3BReynolds%2C+Kellie+Schoolar&rft.aulast=Struble&rft.aufirst=Kimberly&rft.date=2008-05-01&rft.volume=3&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+HIV+and+AIDS&rft.issn=1746-6318&rft_id=info:doi/10.1097%2FCOH.0b013e3282f5f509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COH.0b013e3282f5f509 ER - TY - JOUR T1 - Approaches to establish thresholds for major food allergens and for gluten in food. AN - 71658338; 18522044 JF - Journal of food protection AU - Buchanan, Robert AU - Dennis, Sherri AU - Gendel, Steven AU - Acheson, David AU - Assimon, Sue Anne AU - Beru, Nega AU - Bolger, Philip AU - Carlson, David AU - Carvajal, Ricardo AU - Copp, Catherine AU - Falci, Kenneth AU - Garber, Eric AU - Harden, Elizabeth AU - Kane, Rhonda AU - Kvenberg, John AU - Luccioli, Stefano AU - Park, Douglas AU - Raybourne, Richard AU - Troxell, Terry AU - Vierk, Katherine AU - Threshold Working Group AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA. ; Threshold Working Group Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1043 EP - 1088 VL - 71 IS - 5 SN - 0362-028X, 0362-028X KW - Allergens KW - 0 KW - Glutens KW - 8002-80-0 KW - Index Medicus KW - Food Labeling KW - Humans KW - Food Hypersensitivity -- prevention & control KW - Celiac Disease -- diet therapy KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Consumer Product Safety KW - Glutens -- analysis KW - Food Contamination -- analysis KW - Allergens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71658338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Approaches+to+establish+thresholds+for+major+food+allergens+and+for+gluten+in+food.&rft.au=Buchanan%2C+Robert%3BDennis%2C+Sherri%3BGendel%2C+Steven%3BAcheson%2C+David%3BAssimon%2C+Sue+Anne%3BBeru%2C+Nega%3BBolger%2C+Philip%3BCarlson%2C+David%3BCarvajal%2C+Ricardo%3BCopp%2C+Catherine%3BFalci%2C+Kenneth%3BGarber%2C+Eric%3BHarden%2C+Elizabeth%3BKane%2C+Rhonda%3BKvenberg%2C+John%3BLuccioli%2C+Stefano%3BPark%2C+Douglas%3BRaybourne%2C+Richard%3BTroxell%2C+Terry%3BVierk%2C+Katherine%3BThreshold+Working+Group&rft.aulast=Buchanan&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=71&rft.issue=5&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factors influencing the growth of Salmonella during sprouting of naturally contaminated alfalfa seeds. AN - 71637981; 18522019 AB - In this study, the factors that affect Salmonella growth during sprouting of naturally contaminated alfalfa seeds associated with two previous outbreaks of salmonellosis were examined. A minidrum sprouter equipped with automatic irrigation and rotation systems was built to allow sprouting to be conducted under conditions similar to those used commercially. The growth of Salmonella during sprouting in the minidrum was compared with that observed in sprouts grown in glass jars under conditions commonly used at home. The level of Salmonella increased by as much as 4 log units after 48 h of sprouting in jars but remained constant during the entire sprouting period in the minidrum. The effect of temperature and irrigation frequency on Salmonella growth was examined. Increasing the sprouting temperature from 20 to 30 degrees C increased the Salmonella counts by as much as 2 log units on sprouts grown both in the minidrum and in the glass jars. Decreasing the irrigation frequency from every 20 min to every 2 h during sprouting in the minidrum or from every 4 h to every 24 h during sprouting in the glass jars resulted in an approximately 2-log increase in Salmonella counts. The levels of total aerobic mesophilic bacteria, coliforms, and Salmonella in spent irrigation water closely reflected those found in sprouts, confirming that monitoring of spent irrigation water is a good way to monitor pathogen levels during sprouting. JF - Journal of food protection AU - Fu, Tong-Jen AU - Reineke, Karl F AU - Chirtel, Stuart AU - VanPelt, Olif M AD - U.S. Food and Drug Administration, Summit-Argo, Illinois 60501, USA. tong.fu@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 888 EP - 896 VL - 71 IS - 5 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Salmonella Food Poisoning -- prevention & control KW - Consumer Product Safety KW - Disease Outbreaks -- prevention & control KW - Colony Count, Microbial KW - Seeds -- growth & development KW - Seeds -- microbiology KW - Time Factors KW - Food Contamination -- prevention & control KW - Medicago sativa -- microbiology KW - Salmonella -- growth & development KW - Food Contamination -- analysis KW - Medicago sativa -- physiology KW - Water Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71637981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Factors+influencing+the+growth+of+Salmonella+during+sprouting+of+naturally+contaminated+alfalfa+seeds.&rft.au=Fu%2C+Tong-Jen%3BReineke%2C+Karl+F%3BChirtel%2C+Stuart%3BVanPelt%2C+Olif+M&rft.aulast=Fu&rft.aufirst=Tong-Jen&rft.date=2008-05-01&rft.volume=71&rft.issue=5&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. AN - 70453801; 18069091 AB - Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium ion) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson's-like symptoms in humans and animals. MPTP/MPP+ produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been fully elucidated. Recently, we reported in a microarray study using a midbrain-derived dopaminergic neuronal cell line, MN9D, that MPP+ induced significant changes in a number of genes known to be associated with the dopaminergic system. In this study, we investigated the expression time courses of six genes using real-time RT-PCR, and compared them with the progressive dopaminergic depletion caused by MPP+. Our data showed that dopamine content was significantly decreased after 0.5h of MPP+ (200 microM) exposure and was completely depleted after 40 h. The expression of Gpr37, which is closely related to the pathogenesis of autosomal recessive juvenile Parkinsonism, was up-regulated after 0.5h, and stayed up-regulated up to 48 h. Txnip, which is critical to the adjustment of cellular redox status, was down-regulated after 1h and stayed down-regulated up to 48 h. Ldh1 and Cdo1, which are also involved in oxidative stress, were down-regulated after 16 h and stayed down-regulated up to 48 h. Two pro-apoptotic genes, Egln3 and Bnip3, were down-regulated after 2 and 4h, and stayed down-regulated up to 48 h. These findings suggested that the time course of expression for multiple genes correlated with the dopaminergic depletion; and MPP+-induced neurotoxicity in MN9D cells could be used as a model to further explore the roles of these and other genes in the pathogenesis and possible treatment of PD. JF - Neurochemistry international AU - Wang, Jianyong AU - Duhart, Helen M AU - Xu, Zengjun AU - Patterson, Tucker A AU - Newport, Glenn D AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. jianyong.wang@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1037 EP - 1043 VL - 52 IS - 6 SN - 0197-0186, 0197-0186 KW - BNip3 protein, mouse KW - 0 KW - Carrier Proteins KW - DNA-Binding Proteins KW - Gpr37 protein, mouse KW - Herbicides KW - Immediate-Early Proteins KW - Isoenzymes KW - Membrane Proteins KW - Mitochondrial Proteins KW - RNA, Messenger KW - Receptors, G-Protein-Coupled KW - Txnip protein, mouse KW - Thioredoxins KW - 52500-60-4 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - lactate dehydrogenase 1 KW - EC 1.1.1.27.- KW - Egln3 protein, rat KW - EC 1.14.11.29 KW - Hypoxia-Inducible Factor-Proline Dioxygenases KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Carrier Proteins -- genetics KW - RNA, Messenger -- drug effects KW - Thioredoxins -- genetics KW - DNA-Binding Proteins -- genetics KW - Disease Progression KW - Substantia Nigra -- drug effects KW - Mitochondrial Proteins -- genetics KW - Mice KW - Membrane Proteins -- genetics KW - Isoenzymes -- genetics KW - Substantia Nigra -- metabolism KW - Substantia Nigra -- physiopathology KW - Immediate-Early Proteins -- genetics KW - RNA, Messenger -- metabolism KW - Down-Regulation -- genetics KW - L-Lactate Dehydrogenase -- genetics KW - Receptors, G-Protein-Coupled -- genetics KW - Herbicides -- toxicity KW - Down-Regulation -- drug effects KW - Time Factors KW - Cell Line KW - Parkinsonian Disorders -- physiopathology KW - Neurons -- metabolism KW - Dopamine -- deficiency KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Gene Expression Regulation -- drug effects KW - Parkinsonian Disorders -- metabolism KW - Parkinsonian Disorders -- genetics KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70453801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Comparison+of+the+time+courses+of+selective+gene+expression+and+dopaminergic+depletion+induced+by+MPP%2B+in+MN9D+cells.&rft.au=Wang%2C+Jianyong%3BDuhart%2C+Helen+M%3BXu%2C+Zengjun%3BPatterson%2C+Tucker+A%3BNewport%2C+Glenn+D%3BAli%2C+Syed+F&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2008-05-01&rft.volume=52&rft.issue=6&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protecting poultry workers from exposure to avian influenza viruses. AN - 69786134; 19006973 AB - Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article. JF - Public health reports (Washington, D.C. : 1974) AU - MacMahon, Kathleen L AU - Delaney, Lisa J AU - Kullman, Greg AU - Gibbins, John D AU - Decker, John AU - Kiefer, Max J AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C32, 4676 Columbia Pkwy., Cincinnati, OH 45230, USA. KMacMahon@cdc.gov PY - 2008 SP - 316 EP - 322 VL - 123 IS - 3 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Protective Clothing KW - International Cooperation KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - United States Occupational Safety and Health Administration KW - Guidelines as Topic KW - United States -- epidemiology KW - Risk Assessment KW - Protective Devices KW - Communicable Disease Control -- methods KW - Poultry KW - Animal Husbandry -- methods KW - Zoonoses -- virology KW - Influenza, Human -- virology KW - Agricultural Workers' Diseases -- virology KW - Influenza A virus -- classification KW - Animal Husbandry -- education KW - Influenza in Birds -- prevention & control KW - Occupational Exposure -- prevention & control KW - Influenza, Human -- prevention & control KW - Influenza, Human -- epidemiology KW - Agricultural Workers' Diseases -- prevention & control KW - Agricultural Workers' Diseases -- epidemiology KW - Communicable Diseases, Emerging -- veterinary KW - Influenza in Birds -- virology KW - Influenza A virus -- pathogenicity KW - Communicable Diseases, Emerging -- virology KW - Influenza in Birds -- epidemiology KW - Food-Processing Industry -- methods KW - Zoonoses -- epidemiology KW - Communicable Diseases, Emerging -- prevention & control KW - Food-Processing Industry -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69786134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Protecting+poultry+workers+from+exposure+to+avian+influenza+viruses.&rft.au=MacMahon%2C+Kathleen+L%3BDelaney%2C+Lisa+J%3BKullman%2C+Greg%3BGibbins%2C+John+D%3BDecker%2C+John%3BKiefer%2C+Max+J&rft.aulast=MacMahon&rft.aufirst=Kathleen&rft.date=2008-05-01&rft.volume=123&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-14 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Philos Trans R Soc Lond B Biol Sci. 2001 Jul 29;356(1411):983-9 [11516376] Emerg Infect Dis. 2007 Apr;13(4):527-31 [17553265] Acta Trop. 2002 Jul;83(1):7-11 [12062787] Lancet. 2004 Feb 21;363(9409):587-93 [14987882] Emerg Infect Dis. 1999 Mar-Apr;5(2):195-203 [10221870] Annu Rev Microbiol. 2005;59:553-86 [16153179] J Infect Dis. 2005 Oct 15;192(8):1318-22 [16170747] J Virol Methods. 2006 Mar;132(1-2):113-20 [16271401] Euro Surveill. 2006;11(5):E060504.2 [16816456] Int J Occup Environ Health. 2006 Jul-Sep;12(3):288-9 [16967839] Arch Environ Occup Health. 2005 Mar-Apr;60(2):62-9 [16983858] J Infect Dis. 2006 Nov 1;194 Suppl 2:S139-46 [17163387] CMAJ. 2007 Jan 2;176(1):47-53 [17200390] Emerg Infect Dis. 2006 Nov;12(11):1762-5 [17283632] Vaccine. 2007 May 30;25(22):4376-81 [17459539] Clin Infect Dis. 2007 Jul 1;45(1):4-9 [17554693] J Infect Dis. 2002 Apr 15;185(8):1005-10 [11930308] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Determination of aflatoxins B1, B2, G1, and G2 and ochratoxin A in ginseng and ginger by multitoxin immunoaffinity column cleanup and liquid chromatographic quantitation: collaborative study. AN - 69233577; 18567295 AB - The accuracy, repeatability, and reproducibility characteristics of a method using multitoxin immunoaffinity column cleanup with liquid chromatography (LC) for determination of aflatoxins (AF; sum of aflatoxins B1, B2, G1, and G2) and ochratoxin A (OTA) in powdered ginseng and ginger have been established in a collaborative study involving 13 laboratories from 7 countries. Blind duplicate samples of blank, spiked (AF and OTA added) at levels ranging from 0.25 to 16.0 microg/kg for AF and 0.25 to 8.0 microg/kg for OTA were analyzed. A naturally contaminated powdered ginger sample was also included. Test samples were extracted with methanol and 0.5% aqueous sodium hydrogen carbonate solution (700 + 300, v/v). The extract was centrifuged, diluted with phosphate buffer (PB), filtered, and applied to an immunoaffinity column containing antibodies specific for AF and OTA. After washing the column with water, the toxins were eluted from the column with methanol, and quantified by high-performance LC with fluorescence detection. Average recoveries of AF from ginseng and ginger ranged from 70 to 87% (at spiking levels ranging from 2 to 16 microg/kg), and of OTA, from 86 to 113% (at spiking levels ranging from 1 to 8 microg/kg). Relative standard deviations for within-laboratory repeatability (RSDr) ranged from 2.6 to 8.3% for AF, and from 2.5 to 10.7% for OTA. Relative standard deviations for between-laboratory reproducibility (RSDR) ranged from 5.7 to 28.6% for AF, and from 5.5 to 10.7% for OTA. HorRat values were < or = 2 for the multi-analytes in the 2 matrixes. JF - Journal of AOAC International AU - Trucksess, Mary W AU - Weaver, Carol M AU - Oles, Carolyn J AU - Fry, Frederick S AU - Noonan, Gregory O AU - Betz, Joseph M AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov PY - 2008 SP - 511 EP - 523 VL - 91 IS - 3 SN - 1060-3271, 1060-3271 KW - Aflatoxins KW - 0 KW - Indicators and Reagents KW - Ochratoxins KW - ochratoxin A KW - 1779SX6LUY KW - aflatoxin G2 KW - 2MS0D8WA29 KW - aflatoxin B2 KW - 7SKR7S646P KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Cooperative Behavior KW - Reference Standards KW - Aflatoxin B1 -- analysis KW - Ochratoxins -- analysis KW - Aflatoxins -- analysis KW - Chromatography, Liquid -- methods KW - Panax -- chemistry KW - Ochratoxins -- standards KW - Chromatography, Affinity -- standards KW - Ginger -- chemistry KW - Aflatoxins -- standards KW - Chromatography, Liquid -- standards KW - Chromatography, Affinity -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69233577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+aflatoxins+B1%2C+B2%2C+G1%2C+and+G2+and+ochratoxin+A+in+ginseng+and+ginger+by+multitoxin+immunoaffinity+column+cleanup+and+liquid+chromatographic+quantitation%3A+collaborative+study.&rft.au=Trucksess%2C+Mary+W%3BWeaver%2C+Carol+M%3BOles%2C+Carolyn+J%3BFry%2C+Frederick+S%3BNoonan%2C+Gregory+O%3BBetz%2C+Joseph+M%3BRader%2C+Jeanne+I&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2008-05-01&rft.volume=91&rft.issue=3&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Food Prot. 2001 Aug;64(8):1268-70 [11510675] Anal Bioanal Chem. 2007 Sep;389(1):27-35 [17390125] J Assoc Off Anal Chem. 1991 Sep-Oct;74(5):718-44 [1783583] Food Addit Contam. 1996 Jan;13(1):121-8 [8647302] Food Addit Contam. 2005 Feb;22(2):163-72 [15824007] J AOAC Int. 2006 May-Jun;89(3):624-30 [16792061] J Agric Food Chem. 2006 Jul 26;54(15):5688-93 [16848564] J AOAC Int. 2007 Jul-Aug;90(4):1042-9 [17760342] J AOAC Int. 2006 Jul-Aug;89(4):1095-109 [16915851] Exp Biol Med (Maywood). 2004 Jun;229(6):560-8 [15169976] Microbiol Res. 2004;159(2):113-20 [15293944] J Food Prot. 2004 Aug;67(8):1782-6 [15330551] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry. AN - 69233150; 18567304 AB - Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They were isolated by preparative LC; their structures were established by mass spectrometry and nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2-ethoxy-phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is a sildenafil analog with a dimethylpiperazine ring substituted for the methylpiperazine group. The second analog, hydroxyvardenafil (compound B) is reported for the first time in this study. Hydroxyvardenafil's International Union of Pure and Applied Chemistry name is 2-(2-ethoxy-5-(4-(2-hydroxyethyl)-piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propyl-imidazo[1,5-f][1,2,4]triazin-4(3H)-one. The novel vardenafil analog has a hydroxyl group added to the ethylpiperazine group. JF - Journal of AOAC International AU - Choi, Dong Mi AU - Park, Sangaeh AU - Yoon, Tae Hyung AU - Jeong, Hye Kyoung AU - Pyo, Jae Sung AU - Park, Janghyun AU - Kim, Deukjoon AU - Kwon, Sung Won AD - Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122704, Korea. PY - 2008 SP - 580 EP - 588 VL - 91 IS - 3 SN - 1060-3271, 1060-3271 KW - Imidazoles KW - 0 KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Sulfones KW - Triazines KW - Vardenafil Dihydrochloride KW - 5O8R96XMH7 KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Index Medicus KW - Molecular Structure KW - Purines -- standards KW - Triazines -- analysis KW - Phosphodiesterase Inhibitors -- standards KW - Reference Standards KW - Phosphodiesterase Inhibitors -- chemistry KW - Triazines -- standards KW - Phosphodiesterase Inhibitors -- analysis KW - Purines -- chemistry KW - Purines -- analysis KW - Triazines -- chemistry KW - Sulfones -- chemistry KW - Imidazoles -- standards KW - Piperazines -- chemistry KW - Food Contamination -- analysis KW - Piperazines -- standards KW - Imidazoles -- analysis KW - Mass Spectrometry -- standards KW - Sulfones -- standards KW - Magnetic Resonance Spectroscopy -- standards KW - Chromatography, Liquid -- methods KW - Magnetic Resonance Spectroscopy -- methods KW - Mass Spectrometry -- methods KW - Chromatography, Liquid -- standards KW - Piperazines -- analysis KW - Sulfones -- analysis KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69233150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+analogs+of+sildenafil+and+vardenafil+in+foods+by+column+liquid+chromatography+with+a+photodiode+array+detector%2C+mass+spectrometry%2C+and+nuclear+magnetic+resonance+spectrometry.&rft.au=Choi%2C+Dong+Mi%3BPark%2C+Sangaeh%3BYoon%2C+Tae+Hyung%3BJeong%2C+Hye+Kyoung%3BPyo%2C+Jae+Sung%3BPark%2C+Janghyun%3BKim%2C+Deukjoon%3BKwon%2C+Sung+Won&rft.aulast=Choi&rft.aufirst=Dong&rft.date=2008-05-01&rft.volume=91&rft.issue=3&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Options for occupational health surveillance of workers potentially exposed to engineered nanoparticles: state of the science. AN - 69202021; 18469620 AB - Health authorities, employers, and worker representatives are increasingly faced with making decisions about occupational health surveillance of workers potentially exposed to engineered nanoparticles. This article was developed to identify options that can be considered. The published scientific literature on health effects from engineered and incidental nanoparticles and the principles of occupational health surveillance were reviewed to describe possible options and the evidence base for them. Various options for occupational health surveillance were identified. The options ranged from no action targeted to nanotechnology workers to an approach that includes documentation of the presence of engineered nanoparticles, identification of potentially exposed workers, and general and targeted medical testing. Although the first priority should be to implement appropriate primary preventive measures, additional efforts to monitor employee health may be warranted. Continued research is needed, and the collection of such information for exposure registries may be useful for future epidemiologic studies. JF - Journal of occupational and environmental medicine AU - Schulte, Paul A AU - Trout, Douglas AU - Zumwalde, Ralph D AU - Kuempel, Eileen AU - Geraci, Charles L AU - Castranova, Vincent AU - Mundt, Diane J AU - Mundt, Kenneth A AU - Halperin, William E AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226-1998, USA. pas4@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 517 EP - 526 VL - 50 IS - 5 KW - Index Medicus KW - Environmental Monitoring KW - Evidence-Based Medicine KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Medicine -- methods KW - Occupational Exposure -- prevention & control KW - Safety Management -- methods KW - Nanoparticles -- analysis KW - Occupational Exposure -- adverse effects KW - Nanoparticles -- adverse effects KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69202021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Options+for+occupational+health+surveillance+of+workers+potentially+exposed+to+engineered+nanoparticles%3A+state+of+the+science.&rft.au=Schulte%2C+Paul+A%3BTrout%2C+Douglas%3BZumwalde%2C+Ralph+D%3BKuempel%2C+Eileen%3BGeraci%2C+Charles+L%3BCastranova%2C+Vincent%3BMundt%2C+Diane+J%3BMundt%2C+Kenneth+A%3BHalperin%2C+William+E&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-05-01&rft.volume=50&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e31816515f7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e31816515f7 ER - TY - JOUR T1 - Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration? AN - 69200859; 18470306 AB - Parkinson disease (PD), a chronic neurodegenerative disease, has been proposed to be a multifactorial disorder resulting from a combination of environmental mechanisms (chemical, infectious, and traumatic), aging, and genetic deficits. Microglial activation is important in the pathogenesis of PD. We investigated dopaminergic (DA) neurotoxicity and the underlying mechanisms of formyl-methionyl-leucyl-phenylalanine (fMLP), a bacteria-derived peptide, in relation to PD. We measured DA neurotoxicity using a DA uptake assay and immunocytochemical staining (ICC) in primary mesencephalic cultures from rodents. Microglial activation was observed via ICC, flow cytometry, and superoxide measurement. fMLP can cause selective DA neuronal loss at concentrations as low as 10(-13) M. Further, fMLP (10(-13) M) led to a significant reduction in DA uptake capacity in neuron/glia (N/G) cultures, but not in microglia-depleted cultures, indicating an indispensable role of microglia in fMLP-induced neurotoxicity. Using ICC of a specific microglial marker, OX42, we observed morphologic changes in activated microglia after fMLP treatment. Microglial activation after fMLP treatment was confirmed by flow cytometry analysis of major histocompatibility antigen class II expression on a microglia HAPI cell line. Mechanistic studies revealed that fMLP (10(-13) M)-induced increase in the production of extracellular superoxide from microglia is critical in mediating fMLP-elicited neurotoxicity. Pharmacologic inhibition of NADPH oxidase (PHOX) with diphenylene-iodonium or apocynin abolished the DA neurotoxicity of fMLP. N/G cultures from PHOX-deficient (gp91PHOX-/ -) mice were also insensitive to fMLP-induced DA neurotoxicity. fMLP (10(-13) M) induces DA neurotoxicity through activation of microglial PHOX and subsequent production of superoxide, suggesting a role of fMLP in the central nervous system inflammatory process. JF - Environmental health perspectives AU - Gao, Xi AU - Hu, Xiaoming AU - Qian, Li AU - Yang, Sufen AU - Zhang, Wei AU - Zhang, Dan AU - Wu, Xuefei AU - Fraser, Alison AU - Wilson, Belinda AU - Flood, Patrick M AU - Block, Michelle AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 593 EP - 598 VL - 116 IS - 5 SN - 0091-6765, 0091-6765 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - inflammation KW - microglia KW - neurotoxicity KW - fMLP KW - NADPH oxidase KW - NADPH Oxidase -- metabolism KW - Animals KW - Neurons -- metabolism KW - Enzyme Activation KW - Neurons -- drug effects KW - Mice KW - Mice, Knockout KW - Pregnancy KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Female KW - Parkinson Disease -- etiology KW - Neurodegenerative Diseases -- chemically induced KW - Microglia -- enzymology KW - Central Nervous System Infections -- metabolism KW - Central Nervous System Infections -- etiology KW - Neurodegenerative Diseases -- metabolism KW - Neurodegenerative Diseases -- pathology KW - Dopamine -- metabolism KW - N-Formylmethionine Leucyl-Phenylalanine -- toxicity KW - Microglia -- drug effects KW - Central Nervous System Infections -- pathology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69200859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Formyl-methionyl-leucyl-phenylalanine-induced+dopaminergic+neurotoxicity+via+microglial+activation%3A+a+mediator+between+peripheral+infection+and+neurodegeneration%3F&rft.au=Gao%2C+Xi%3BHu%2C+Xiaoming%3BQian%2C+Li%3BYang%2C+Sufen%3BZhang%2C+Wei%3BZhang%2C+Dan%3BWu%2C+Xuefei%3BFraser%2C+Alison%3BWilson%2C+Belinda%3BFlood%2C+Patrick+M%3BBlock%2C+Michelle%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Xi&rft.date=2008-05-01&rft.volume=116&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histol Histopathol. 2006 Jun;21(6):673-8 [16528677] Blood. 1996 Jul 15;88(2):690-6 [8695817] J Biochem. 2006 Nov;140(5):739-45 [17030506] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] J Immunol. 2007 Feb 1;178(3):1759-66 [17237425] Glia. 2007 Apr 1;55(5):453-62 [17203472] Brain Res. 2007 Mar 23;1138:196-202 [17275793] J Am Acad Nurse Pract. 2007 Apr;19(4):179-97 [17430539] Neurosci Lett. 1996 Jun 14;211(1):13-6 [8809836] Ann Neurol. 1998 Sep;44(3 Suppl 1):S115-20 [9749582] Blood. 1999 Mar 1;93(5):1464-76 [10029572] Immunopharmacol Immunotoxicol. 1999 Aug;21(3):397-419 [10466071] J Exp Med. 1999 Sep 6;190(5):741-7 [10477558] Ann Neurol. 2005 Feb;57(2):176-9 [15668963] FASEB J. 2005 Apr;19(6):550-7 [15791005] FASEB J. 2006 Feb;20(2):251-8 [16449797] J Neural Transm Suppl. 2007;(72):113-20 [17982884] Brain Res Rev. 2007 Nov;56(1):119-47 [17659349] J Biol Chem. 2008 Mar 21;283(12):7983-93 [18160398] Br J Pharmacol. 1998 Nov;125(5):1109-14 [9846652] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Neurobiol Aging. 2000 May-Jun;21(3):463-73 [10858596] Immunol Rev. 2000 Oct;177:185-94 [11138775] J Pharmacol Exp Ther. 2001 Sep;298(3):1133-41 [11504811] Neural Plast. 2001;8(1-2):99-110 [11530892] J Immunol. 2002 Jan 1;168(1):434-42 [11751990] Neuroscience. 2002;112(1):7-11 [12044467] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] Neurobiol Dis. 2002 Aug;10(3):366-77 [12270697] J Neurochem. 2002 Nov;83(4):973-83 [12421370] Nat Rev Neurosci. 2003 Feb;4(2):103-12 [12563281] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Scand J Immunol. 2004 Jan;59(1):25-33 [14723618] Immunology. 2004 Jun;112(2):201-10 [15147563] Drugs. 2004;64(19):2143-57 [15456332] Biochem Biophys Res Commun. 1985 Apr 16;128(1):297-304 [2985075] Neurology. 1988 Aug;38(8):1285-91 [3399080] J Neurosci Res. 1990 Sep;27(1):36-42 [2254955] Blood. 1993 Jul 15;82(2):633-40 [8329716] Nature. 1993 Aug 12;364(6438):584 [8350919] Ann Neurol. 1994;36 Suppl:S25-8 [8017885] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11031 ER - TY - JOUR T1 - Adolescent use of insulin and patient-controlled analgesia pump technology: a 10-year Food and Drug Administration retrospective study of adverse events. AN - 69173873; 18450857 AB - From January 1, 2005, through December 31, 2005, the Food and Drug Administration received 5 adolescent death reports associated with the use of insulin pumps, raising concerns about use of this device in this age group. To understand better the types of infusion pump-related problems in adolescents, we performed a comprehensive evaluation of insulin and patient-controlled analgesic pump-related adverse events reported for adolescents that were received by the Food and Drug Administration from 1996 to 2005. A search for medical device adverse event reports from January 1, 1996 through December 31, 2005, involving insulin pumps or patient-controlled analgesic pumps used by patients who were aged 12 to 21 years was conducted in the Food and Drug Administration's Manufacturer and User Facility Device Experience Database. Reports were reviewed for demographic characteristics, type of adverse event, and patient morbidity, and potential contributory factors were classified from narratives in the reports. A total of 1674 reports were identified: 1594 for insulin pumps and 53 for patient-controlled analgesic pumps. In reports of insulin pump events, there were 13 reported deaths, 2 reports that indicated possible suicide attempts, and several additional reports indicating severe hypoglycemic or hyperglycemic events that seemed to be device-related. A total of 102 (6.4%) insulin-pump reports highlighted factors that may have contributed to the adverse event, including problems associated with compliance, education, sports-related activities, and dropping or damaging the pump. Eighty-two percent of cases involving the insulin pump resulted in hospitalization. Half of the reports involving patient-controlled analgesic pumps indicated that the patient received an excess of medication; tampering and noncompliance were evident in some cases. Adolescents are a special population who deserve careful consideration of risk and benefit for use of device technology. Studies need to further identify safety problems in this age group. JF - Pediatrics AU - Cope, Judith U AU - Morrison, Audrey E AU - Samuels-Reid, Joy AD - Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Food and Drug Administration, Rockville, Maryland 20850, USA. Judith.cope@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - e1133 EP - e1138 VL - 121 IS - 5 KW - Abridged Index Medicus KW - Index Medicus KW - Hypoglycemia -- etiology KW - Adolescent Behavior KW - Humans KW - Adult KW - Psychology, Adolescent KW - Hyperglycemia -- etiology KW - Child KW - Equipment Failure KW - Adolescent KW - Male KW - Female KW - Insulin Infusion Systems -- adverse effects KW - Analgesia, Patient-Controlled -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69173873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Adolescent+use+of+insulin+and+patient-controlled+analgesia+pump+technology%3A+a+10-year+Food+and+Drug+Administration+retrospective+study+of+adverse+events.&rft.au=Cope%2C+Judith+U%3BMorrison%2C+Audrey+E%3BSamuels-Reid%2C+Joy&rft.aulast=Cope&rft.aufirst=Judith&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=e1133&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-1707 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pediatrics. 2008 Sep;122(3):682; author reply 682-3 [18762546] Pediatrics. 2008 Aug;122(2):473-4; author reply 474 [18676571] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-1707 ER - TY - JOUR T1 - Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk. AN - 69160256; 18412094 AB - This paper describes the development and optimization of a multi-residue veterinary drug screening method for whole milk. The drug residues of regulatory interest in milk include beta-lactams, sulfonamides, tetracyclines, fluoroquinolones, and macrolides. Milk samples were extracted with acetonitrile and the samples were then subjected to a clean-up procedure using a bonded solid-phase extraction cartridge and a molecular weight cut-off filter. Liquid chromatography/tandem mass spectrometry (LC/MS/MS) triple quadrupole electrospray methods were developed to monitor for the drugs in milk. Since established tolerance levels are set for most of these drugs in milk, the initial screening procedure was semi-quantitative, where samples were compared to the response of a positive control. The positive control, consisting of an extract from a portion of milk fortified with the drugs at half their allowed levels, was used to set the laboratory's minimum response criteria for unknown samples. Confirmatory analyses, with additional ion transitions for each residue, were performed on the same extracts. JF - Rapid communications in mass spectrometry : RCM AU - Turnipseed, Sherri B AU - Andersen, Wendy C AU - Karbiwnyk, Christine M AU - Madson, Mark R AU - Miller, Keith E AD - Animal Drugs Research Center, Food and Drug Administration, Denver Federal Center, Denver, CO 80225, USA. sherri.turnipseed@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1467 EP - 1480 VL - 22 IS - 10 SN - 0951-4198, 0951-4198 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Animals KW - Cattle KW - Food Analysis -- methods KW - Veterinary Drugs -- analysis KW - Food Contamination -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Milk -- chemistry KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69160256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Multi-class%2C+multi-residue+liquid+chromatography%2Ftandem+mass+spectrometry+screening+and+confirmation+methods+for+drug+residues+in+milk.&rft.au=Turnipseed%2C+Sherri+B%3BAndersen%2C+Wendy+C%3BKarbiwnyk%2C+Christine+M%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E&rft.aulast=Turnipseed&rft.aufirst=Sherri&rft.date=2008-05-01&rft.volume=22&rft.issue=10&rft.spage=1467&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/10.1002%2Frcm.3532 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-10 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/rcm.3532 ER - TY - JOUR T1 - Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients. AN - 69124864; 18433667 AB - The aim of this study is to quantify excess absolute risk (EAR) and excess relative risk (ERR) of secondary leukemia among a large population-based group of testicular cancer survivors. We identified 42,722 1-year survivors of testicular cancer within 14 population-based cancer registries in Europe and North America (1943-2002). Poisson regression analysis was used to model EAR (per 100,000 person-years [PY]) and ERR of secondary leukemia. Cumulative risks were calculated using a competing risk model. Secondary leukemia developed in 89 patients (EAR = 10.8 per 100,000 PY, 95% confidence interval [CI] = 7.6-14.6; ERR = 1.6, 95%CI = 1.0-2.2). Statistically significantly elevated risks were observed for acute myeloid leukemia (AML) (EAR = 7.2, 95%CI = 4.7-10.2) and acute lymphoblastic leukemia (EAR = 1.3, 95%CI = 0.4-2.8). In multivariate analyses, AML risk was higher among patients whose initial management included chemotherapy compared to those receiving radiotherapy alone (p = 0.1). Excess cumulative leukemia risk was approximately 0.23% by 30 years after testicular cancer diagnosis. Although ERR of leukemia following testicular cancer is large, EAR and cumulative risk, which are better gauges of the population burden, are small. JF - Annals of epidemiology AU - Howard, Regan AU - Gilbert, Ethel AU - Lynch, Charles F AU - Hall, Per AU - Storm, Hans AU - Holowaty, Eric AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Allan, James M AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. reganho@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 416 EP - 421 VL - 18 IS - 5 KW - Index Medicus KW - Registries KW - North America -- epidemiology KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Europe -- epidemiology KW - Male KW - Multivariate Analysis KW - Testicular Neoplasms -- therapy KW - Leukemia -- chemically induced KW - Neoplasms, Second Primary -- epidemiology KW - Leukemia -- epidemiology KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69124864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Risk+of+leukemia+among+survivors+of+testicular+cancer%3A+a+population-based+study+of+42%2C722+patients.&rft.au=Howard%2C+Regan%3BGilbert%2C+Ethel%3BLynch%2C+Charles+F%3BHall%2C+Per%3BStorm%2C+Hans%3BHolowaty%2C+Eric%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BAllan%2C+James+M%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2008-05-01&rft.volume=18&rft.issue=5&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=1873-2585&rft_id=info:doi/10.1016%2Fj.annepidem.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Jul 19;92(14):1165-71 [10904090] J Clin Oncol. 2007 Oct 1;25(28):4370-8 [17906202] J Clin Oncol. 1984 Oct;2(10):1080-7 [6092549] Acta Radiol Oncol. 1984;23(5):305-13 [6095600] Lancet. 1991 Aug 10;338(8763):359-63 [1713639] Int J Radiat Oncol Biol Phys. 1992;24(5):913-9 [1447034] J Natl Cancer Inst. 1993 Jan 6;85(1):36-40 [7677934] J Clin Oncol. 1993 Mar;11(3):415-24 [8445415] J Natl Cancer Inst. 1995 Jan 4;87(1):58-60 [7666466] J Natl Cancer Inst. 1997 Oct 1;89(19):1429-39 [9326912] Leukemia. 1999 Apr;13 Suppl 1:S37-41 [10232363] Expert Rev Anticancer Ther. 2005 Feb;5(1):123-38 [15757445] J Natl Cancer Inst. 2005 Sep 21;97(18):1354-65 [16174857] Lancet. 2006 Mar 4;367(9512):754-65 [16517276] Int J Cancer. 2007 Feb 1;120(3):623-31 [17096341] Br J Cancer. 2007 Feb 12;96(3):529-33 [17262080] Leuk Lymphoma. 2001 May;41(5-6):559-70 [11378573] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annepidem.2008.01.003 ER - TY - JOUR T1 - Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. AN - 69110887; 18096873 AB - Carbon nanotubes (CNT), with their applications in industry and medicine, may lead to new risks to human health. CNT induce a robust pulmonary inflammation and oxidative stress in rodents. Realistic exposures to CNT may occur in conjunction with other pathogenic impacts (microbial infections) and trigger enhanced responses. We evaluated interactions between pharyngeal aspiration of single-walled CNT (SWCNT) and bacterial pulmonary infection of C57BL/6 mice with Listeria monocytogenes (LM). Mice were given SWCNT (0, 10, and 40 mug/mouse) and 3 days later were exposed to LM (10(3) bacteria/mouse). Sequential exposure to SWCNT/LM amplified lung inflammation and collagen formation. Despite this robust inflammatory response, SWCNT pre-exposure significantly decreased the pulmonary clearance of LM-exposed mice measured 3 to 7 days after microbial infection versus PBS/LM-treated mice. Decreased bacterial clearance in SWCNT-pre-exposed mice was associated with decreased phagocytosis of bacteria by macrophages and a decrease in nitric oxide production by these phagocytes. Pre-incubation of naïve alveolar macrophages with SWCNT in vitro also resulted in decreased nitric oxide generation and suppressed phagocytizing activity toward LM. Failure of SWCNT-exposed mice to clear LM led to a continued elevation in nearly all major chemokines and acute phase cytokines into the later course of infection. In SWCNT/LM-exposed mice, bronchoalveolar lavage neutrophils, alveolar macrophages, and lymphocytes, as well as lactate dehydrogenase level, were increased compared with mice exposed to SWCNT or LM alone. In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations. JF - American journal of respiratory cell and molecular biology AU - Shvedova, Anna A AU - Fabisiak, James P AU - Kisin, Elena R AU - Murray, Ashley R AU - Roberts, Jenny R AU - Tyurina, Yulia Y AU - Antonini, James M AU - Feng, Wei Hong AU - Kommineni, Choudari AU - Reynolds, Jeffrey AU - Barchowsky, Aaron AU - Castranova, Vince AU - Kagan, Valerian E AD - Pathology/Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. ats1@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 579 EP - 590 VL - 38 IS - 5 KW - Cytokines KW - 0 KW - Nanotubes, Carbon KW - Index Medicus KW - Bronchoalveolar Lavage Fluid -- immunology KW - Animals KW - Cytokines -- biosynthesis KW - Weight Loss KW - Mice, Inbred C57BL KW - Bronchoalveolar Lavage Fluid -- microbiology KW - Mice KW - Phagocytosis KW - Macrophages, Alveolar -- immunology KW - Female KW - Pneumonia -- chemically induced KW - Listeriosis -- pathology KW - Pneumonia -- microbiology KW - Listeriosis -- immunology KW - Lung -- pathology KW - Nanotubes, Carbon -- toxicity KW - Pneumonia -- pathology KW - Nanotubes, Carbon -- microbiology KW - Lung -- immunology KW - Listeria monocytogenes -- pathogenicity KW - Pneumonia -- immunology KW - Listeriosis -- physiopathology KW - Lung -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69110887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Sequential+exposure+to+carbon+nanotubes+and+bacteria+enhances+pulmonary+inflammation+and+infectivity.&rft.au=Shvedova%2C+Anna+A%3BFabisiak%2C+James+P%3BKisin%2C+Elena+R%3BMurray%2C+Ashley+R%3BRoberts%2C+Jenny+R%3BTyurina%2C+Yulia+Y%3BAntonini%2C+James+M%3BFeng%2C+Wei+Hong%3BKommineni%2C+Choudari%3BReynolds%2C+Jeffrey%3BBarchowsky%2C+Aaron%3BCastranova%2C+Vince%3BKagan%2C+Valerian+E&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2008-05-01&rft.volume=38&rft.issue=5&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=1535-4989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2002 Nov;70(1):110-9 [12388840] Int Arch Occup Environ Health. 2008 May;81(6):721-6 [17849141] J Immunol. 2003 May 1;170(9):4457-64 [12707321] Toxicol Sci. 2003 May;73(1):66-71 [12700415] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7812-7 [12810961] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] J Nanosci Nanotechnol. 2003 Feb-Apr;3(1-2):63-73 [12908231] J Toxicol Environ Health A. 2004 Jan 9;67(1):87-107 [14668113] Biomaterials. 2004 May;25(12):2399-407 [14741605] Curr Mol Med. 2004 Sep;4(6):681-9 [15357216] Nat Rev Immunol. 2004 Oct;4(10):812-23 [15459672] Toxicol Appl Pharmacol. 2004 Nov 1;200(3):206-18 [15504457] Cell. 1993 May 7;73(3):457-67 [8387893] Clin Immunol Immunopathol. 1994 Sep;72(3):283-92 [7914840] J Appl Physiol (1985). 1994 Sep;77(3):1060-6 [7836104] Eur J Immunol. 1995 Jan;25(1):200-6 [7843232] Environ Health Perspect. 1994 Dec;102 Suppl 10:37-42 [7705302] Immunity. 1995 Jul;3(1):109-17 [7621071] Immunity. 1997 Sep;7(3):419-32 [9324362] Anal Chem. 1998 Jul 1;70(13):2446-53 [9666719] Immunity. 1999 Jan;10(1):29-38 [10023768] Am J Respir Cell Mol Biol. 1999 Apr;20(4):561-72 [10100987] Am J Respir Cell Mol Biol. 2005 Jul;33(1):97-104 [15845864] Biomaterials. 2005 Dec;26(35):7260-75 [16023200] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Annu Rev Immunol. 2006;24:99-146 [16551245] J Virol. 2006 May;80(9):4521-7 [16611912] Crit Rev Toxicol. 2006 Mar;36(3):189-217 [16686422] Nature. 2006 May 11;441(7090):235-8 [16648838] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] Toxicol Lett. 2006 Aug 1;165(1):88-100 [16527436] Immunobiology. 2006;211(6-8):511-24 [16920490] Ann Occup Hyg. 2007 Jan;51(1):1-12 [17041243] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Annu Rev Immunol. 2007;25:821-52 [17201677] Nanomedicine. 2007 Mar;3(1):95-101 [17379174] Pak J Pharm Sci. 2007 Apr;20(2):157-62 [17416573] J Biol Inorg Chem. 2007 May;12(4):527-34 [17353996] Toxicol Appl Pharmacol. 2007 Jun 15;221(3):339-48 [17482224] Nanomedicine. 2007 Jun;3(2):168-71 [17468052] Langmuir. 2007 Aug 14;23(17):8670-3 [17658863] Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10 [17573146] J Food Prot. 2007 Aug;70(8):1844-9 [17803140] Acta Biomater. 2008 Mar;4(2):273-83 [17720641] Blood. 2000 Apr 15;95(8):2484-90 [10753825] Med Mycol. 2000;38 Suppl 1:335-47 [11204162] Environ Health Perspect. 2001 May;109(5):515-21 [11401764] Exp Mol Pathol. 2002 Feb;72(1):1-9 [11784117] Free Radic Biol Med. 2002 Sep 1;33(5):676-84 [12208354] Environ Health Perspect. 2002 Nov;110(11):1105-11 [12417481] N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Protecting Poultry Workers from Avian Influenza (Bird Flu) AN - 58792232; 2008-197923 AB - The National Institute for Occupational Safety and Health (NIOSH) requests help in protecting poultry workers from infection with viruses that cause avian influenza (also known as bird flu). Although human infection with avian influenza viruses is rare, workers infected with certain types of these viruses may become ill or die. Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2008, 32 pp. AU - National Institute for Occupational Safety and Health Y1 - 2008/05// PY - 2008 DA - May 2008 EP - 32p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Agriculture and agricultural policy - Livestock, meat, and animal products industry KW - Health conditions and policy - Diseases and disorders KW - Agriculture and agricultural policy - Processed food industries KW - Environment and environmental policy - Animals KW - Social conditions and policy - Public safety and security KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Food industry KW - Safety measures KW - Birds KW - Communicable diseases KW - Avian influenza KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58792232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=&rft.spage=32p&rft.isbn=&rft.btitle=Protecting+Poultry+Workers+from+Avian+Influenza+%28Bird+Flu%29&rft.title=Protecting+Poultry+Workers+from+Avian+Influenza+%28Bird+Flu%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-128/ LA - English DB - PAIS Index N1 - Date revised - 2008-10-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Active and passive smoking and depression among Japanese workers AN - 57303601; 200916176 AB - Objective To assess the relation of passive and active smoking to depressive symptoms in 1839 men and 931 women working in a suburb of Tokyo in 2002. Method Self-reported smoking history and exposure to passive smoking (no, occasional, or regular) at work and at home. Depressive symptoms according to the Center for Epidemiologic Studies Depression Scale, with a cut-off point of 16. Results Compared to never smokers unexposed to passive smoking, never smokers reporting regular and occasional exposure to passive smoking at work had increased depressive symptoms. The adjusted odds ratios (aORs) were 1.92 (95% confidence interval (CI) 1.14, 3.23) for regular exposure and 1.63 (95% CI 1.08, 2.47) for occasional exposure. Current smokers had significantly increased depressive symptoms (aOR ranging from 2.25 to 2.38) but former smokers had only marginal increases of depressive symptoms (aOR ranging from 1.43 to 1.55). Gender did not modify the effects of active/passive smoking on depressive symptoms. Conclusion Passive smoking at work and current smoking appear associated with higher levels of depressive symptoms. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Nakata, Akinori AU - Takahashi, Masaya AU - Ikeda, Tomoko AU - Hojou, Minoru AU - Nigam, Jeannie A AU - Swanson, Naomi G AD - National Institute for Occupational Safety and Health, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 451 EP - 456 PB - Elsevier Ltd, The Netherlands VL - 46 IS - 5 SN - 0091-7435, 0091-7435 KW - Passive smoking Smoking Depressive symptoms Working population Epidemiology Occupational health KW - Smoking KW - Passive smoking KW - Depression KW - Gender KW - Marginal KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Active+and+passive+smoking+and+depression+among+Japanese+workers&rft.au=Nakata%2C+Akinori%3BTakahashi%2C+Masaya%3BIkeda%2C+Tomoko%3BHojou%2C+Minoru%3BNigam%2C+Jeannie+A%3BSwanson%2C+Naomi+G&rft.aulast=Nakata&rft.aufirst=Akinori&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.01.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Passive smoking; Smoking; Gender; Marginal; Confidence intervals DO - http://dx.doi.org/10.1016/j.ypmed.2008.01.024 ER - TY - JOUR T1 - The quality of medical care for comorbid conditions of depressed elders AN - 57251326; 200823594 AB - Objectives: In light of large variation in the quality of medical care, this study assesses the extent to which medical care for depressed elders is consistent with systematic quality standards. Method: Using the Donabedian model, we assess factors related to two quality measures: medical service fit and medical provider contact. We assessed 110 depressed older adults with comorbid conditions through practical guidelines of medical services. Results: We found large variation in the quality of medical care and differences between two quality measures. Structure (Medigap insurance and clinical factors) and process factors (medical professional visits, ER visits, and adequacy of informal care) influenced the quality of medical care. Conclusion: Emphasizing accuracy in quality measures, quality disparities by medical conditions call attention to the risky population with certain conditions targeted for closer follow-up. Appropriate medical care processes can enhance the quality. Adapted from the source document. JF - Aging & Mental Health AU - Hong, Song-Iee AU - Morrow-Howell, Nancy AU - Proctor, Enola AU - Wentz, Joan D AU - Rubin, Eugene AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Missouri Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 323 EP - 332 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 3 SN - 1360-7863, 1360-7863 KW - Measurement KW - Elderly people KW - Quality of care KW - Health care KW - Medical services KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+%26+Mental+Health&rft.atitle=The+quality+of+medical+care+for+comorbid+conditions+of+depressed+elders&rft.au=Hong%2C+Song-Iee%3BMorrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BWentz%2C+Joan+D%3BRubin%2C+Eugene&rft.aulast=Hong&rft.aufirst=Song-Iee&rft.date=2008-05-01&rft.volume=12&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Aging+%26+Mental+Health&rft.issn=13607863&rft_id=info:doi/10.1080%2F13607860802121118 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - CODEN - AMHTFD N1 - SubjectsTermNotLitGenreText - Health care; Quality of care; Elderly people; Comorbidity; Medical services; Measurement DO - http://dx.doi.org/10.1080/13607860802121118 ER - TY - JOUR T1 - Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder AN - 57244960; 200821706 AB - Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 - 4.7%, -6.5 - 4.0%, -16.6 - 3.4%, -19.4 - 3.7%, -24.1 - 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 - 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 - 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Hediger, Mary L AU - England, Lucinda J AU - Molloy, Cynthia A AU - Yu, Kai F AU - Manning-Courtney, Patricia AU - Mills, James L AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health (DESPR, NICHD, NIH), Department of Health and Human Services, Bldg 6100, Rm 7B03, MSC 7510, 9000 Rockville Pike, Bethesda, MD 20892-7510, USA hedigerm@exchange.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 848 EP - 856 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 5 SN - 0162-3257, 0162-3257 KW - Bones KW - Diet KW - Autistic children KW - Child development KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57244960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Reduced+Bone+Cortical+Thickness+in+Boys+with+Autism+or+Autism+Spectrum+Disorder&rft.au=Hediger%2C+Mary+L%3BEngland%2C+Lucinda+J%3BMolloy%2C+Cynthia+A%3BYu%2C+Kai+F%3BManning-Courtney%2C+Patricia%3BMills%2C+James+L&rft.aulast=Hediger&rft.aufirst=Mary&rft.date=2008-05-01&rft.volume=38&rft.issue=5&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-007-0453-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic children; Autistic spectrum disorders; Bones; Child development; Diet DO - http://dx.doi.org/10.1007/s10803-007-0453-6 ER - TY - JOUR T1 - Outcomes for Youth Residential Treatment Programs Using Administrative Data from the Child Welfare System: A Risk-Adjustment Application AN - 57233558; 200820006 AB - This study assessed whether administrative data from the public child welfare system could be used to develop risk-adjusted performance reports for residential mental health programs for adolescents. Regression methods were used with 3,759 residential treatment spells for 2,784 children and youth to determine which outcomes could be adequately risk adjusted for case mix. Expected outcomes were created for each residential program given its case mix; then, expected and achieved outcomes were compared. For most programs, achieved results did not differ significantly from expected results for individual outcomes. Overall, outcomes achieved were not impressive. Only one quarter of spells resulted in a youth being maintained in a single less restrictive setting in the year following discharge. Methodological implications of this study suggest further refinements are needed for child welfare administrative data in order to develop risk-adjusted report cards of program performance. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - McMillen, J Curtis AU - Lee, Bethany R AU - Jonson-Reid, Melissa AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1196, St. Louis, MO 63130, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 189 EP - 197 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 3 SN - 0894-587X, 0894-587X KW - Residential treatment KW - Mental health services KW - Risk adjustment KW - Child protection KW - Young people KW - Child welfare KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Outcomes+for+Youth+Residential+Treatment+Programs+Using+Administrative+Data+from+the+Child+Welfare+System%3A+A+Risk-Adjustment+Application&rft.au=McMillen%2C+J+Curtis%3BLee%2C+Bethany+R%3BJonson-Reid%2C+Melissa&rft.aulast=McMillen&rft.aufirst=J&rft.date=2008-05-01&rft.volume=35&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0155-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Young people; Risk adjustment; Child protection; Residential treatment; Mental health services; Child welfare DO - http://dx.doi.org/10.1007/s10488-007-0155-6 ER - TY - JOUR T1 - Does participation in the food stamp program increase the prevalence of obesity and health care spending? AN - 37030536; 3804128 AB - We use panel data techniques and information on state-level Food Stamp Program characteristics to obtain unbiased estimates of the impact of Food Stamp Program participation on weight status and health care spending among nonelderly adults. Our results suggest that program participation by women leads to a 5.9% (p = 0.07) increase in their likelihood of overweight and obesity, which is smaller than previous estimates, and to higher medical expenditures. The direct effect of program participation on medical spending through higher discretionary income is significantly larger than the indirect effect through changes in weight status. Reprinted by permission of the American Agricultural Economics Association JF - American journal of agricultural economics AU - Meyerhoefer, Chad D AU - Pylypchuk, Yuriy AD - US Agency for Healthcare Research and Quality Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 287 EP - 305 VL - 90 IS - 2 SN - 0002-9092, 0002-9092 KW - Economics KW - Food stamps KW - Obesity KW - Health expenditure KW - Food KW - Government programmes KW - Social security KW - U.S.A. KW - Panel data KW - Poverty alleviation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37030536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+agricultural+economics&rft.atitle=Does+participation+in+the+food+stamp+program+increase+the+prevalence+of+obesity+and+health+care+spending%3F&rft.au=Meyerhoefer%2C+Chad+D%3BPylypchuk%2C+Yuriy&rft.aulast=Meyerhoefer&rft.aufirst=Chad&rft.date=2008-05-01&rft.volume=90&rft.issue=2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=American+journal+of+agricultural+economics&rft.issn=00029092&rft_id=info:doi/10.1111%2Fj.1467-8276.2007.01125.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11923 11949 13521; 9963 9962; 5576 5574 10472; 5114; 8823; 5780 4618; 9144 8160 8163; 433 293 14 DO - http://dx.doi.org/10.1111/j.1467-8276.2007.01125.x ER - TY - RPRT T1 - FOREWORD AN - 236448189 AB - NLEHS/NIH, the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention (NIOSH/CDC), and the National Center for Toxicological Research of the Food and Drug Administration (NCTR/FDA) Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236448189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYLENE BLUE TRIHYDRATE (CAS NO. 7220-79-3) IN F344/N RATS AND B6C3F^sub 1^ MICE (GAVAGE STUDIES) AN - 236441104; 18685714 AB - Methylene blue trihydrate has a variety of medical uses, including the treatment of methemoglobinemia and psychiatric disorders and as a disinfectant and biological stain. We studied the effects of methylene blue trihydrate on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing methylene blue trihydrate in aqueous methylcellulose directly into the stomachs of male and female rats and mice. Groups of 50 male and female rats received 5, 25, or 50 milligrams of methylene blue trihydrate per kilogram body weight five days per week for two years; groups of 50 male and female mice received 2.5, 12.5, or 25 milligrams of methylene blue per kilogram of body weight for the same duration. Groups of animals receiving methylcellulose alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The two highest dose groups of male and female rats weighed less than the control animals, while the two highest dose groups of female mice weighed more than their corresponding control group. In male and female rats and mice, the blood of the animals was affected, with animals receiving the highest doses experiencing methemoglobinemia and anemia. This caused secondary injury to the spleen in these animals. Cancer of the pancreatic islets was increased in male rats receiving methylene blue trihydrate, and some uncommon tumors of the small intestine were seen in exposed male mice. There was a slight increase in malignant lymphomas in exposed male and female mice. We conclude that exposure to methylene blue caused pancreatic islet tumors in male rats and small intestine tumors in male mice. Malignant lymphomas in male and female mice were possibly associated with methylene blue trihydrate exposure. Methylene blue trihydrate caused blood abnormalities and anemia in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 EP - 224 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Enzyme Inhibitors KW - Mutagens KW - Methylene Blue KW - Rodents KW - Toxicology KW - Carcinogens KW - Anemia KW - Lymphomas KW - Animals KW - DNA Damage KW - Anemia -- chemically induced KW - Islets of Langerhans -- drug effects KW - Lymphoma -- chemically induced KW - Methemoglobinemia -- pathology KW - Anemia -- pathology KW - Neoplasms, Experimental -- pathology KW - Islets of Langerhans -- pathology KW - Rats KW - Chromosome Aberrations -- chemically induced KW - Rats, Inbred F344 KW - Intestinal Neoplasms -- chemically induced KW - CHO Cells KW - Intestine, Small -- drug effects KW - Methemoglobinemia -- chemically induced KW - Male KW - Administration, Oral KW - Intestinal Neoplasms -- pathology KW - Cricetulus KW - Pancreatic Neoplasms -- chemically induced KW - Mice KW - Mice, Inbred Strains KW - Pancreatic Neoplasms -- pathology KW - Sister Chromatid Exchange -- drug effects KW - Body Weight -- drug effects KW - Intestine, Small -- pathology KW - Lymphoma -- pathology KW - Female KW - Cricetinae KW - Neoplasms, Experimental -- etiology KW - Enzyme Inhibitors -- toxicity KW - Toxicity Tests KW - Mutagens -- toxicity KW - Methylene Blue -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+METHYLENE+BLUE+TRIHYDRATE+%28CAS+NO.+7220-79-3%29+IN+F344%2FN+RATS+AND+B6C3F%5Esub+1%5E+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Document feature - Tables; Diagrams; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236440598 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236440598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Enzyme-Linked Immunosorbent Assays Using Novel Japanese Encephalitis Virus Antigen Improve the Accuracy of Clinical Diagnosis of Flavivirus Infections AN - 21498045; 12494269 AB - The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses. The envelope (E) glycoprotein fusion peptide contains immunodominant cross-reactive determinants. Using a recombinant Japanese encephalitis virus (JEV) premembrane and E expression plasmid producing JEV virus-like particles (VLPs), dramatic reductions in cross-reactivity were produced by the G106K-L107D (KD) double-mutant VLP against a panel of flavivirus murine monoclonal antibodies. Human serum panels from patients with recent flavivirus infections were analyzed to compare the accuracy of JEV wild-type (WT) and KD VLPs as serodiagnostic antigens in enzyme-linked immunosorbent assays. Statistical analysis demonstrated significant differences in assay performances for accurate determination of current JEV infections between WT and KD antigens by detecting immunoglobulin M antibodies at a serum dilution of 1:4,000 (likelihood ratios = 2.74 [WT] and 22 [KD]). The application and continued development of cross-reactivity-reduced antigens should improve both flavivirus infection serodiagnosis and estimates of disease burden. JF - Clinical and Vaccine Immunology AU - Chiou, Shyan-Song AU - Crill, Wayne D AU - Chen, Li-Kuang AU - Chang, Gwong-Jen J AD - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, gxc7@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 825 EP - 835 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 15 IS - 5 SN - 1556-679X, 1556-679X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Cross-reactivity KW - Virus-like particles KW - Monoclonal antibodies KW - Statistical analysis KW - Secondary infection KW - Plasmids KW - Flavivirus KW - Encephalitis KW - Envelopes KW - Japanese encephalitis virus KW - Glycoproteins KW - Immunoglobulin M KW - F 06905:Vaccines KW - V 22300:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Enzyme-Linked+Immunosorbent+Assays+Using+Novel+Japanese+Encephalitis+Virus+Antigen+Improve+the+Accuracy+of+Clinical+Diagnosis+of+Flavivirus+Infections&rft.au=Chiou%2C+Shyan-Song%3BCrill%2C+Wayne+D%3BChen%2C+Li-Kuang%3BChang%2C+Gwong-Jen+J&rft.aulast=Chiou&rft.aufirst=Shyan-Song&rft.date=2008-05-01&rft.volume=15&rft.issue=5&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00004-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Envelopes; Virus-like particles; Cross-reactivity; Monoclonal antibodies; Statistical analysis; Glycoproteins; Secondary infection; Plasmids; Immunoglobulin M; Encephalitis; Japanese encephalitis virus; Flavivirus DO - http://dx.doi.org/10.1128/CVI.00004-08 ER - TY - JOUR T1 - Biomedical Ultrasound/Bioresponse to Vibration: Ultrasonic Characterization of Bone I AN - 21251822; 10959572 JF - Journal of the Acoustical Society of America AU - Wear, KA AU - Raum, K AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave, Bldg 62, Rm 3108, Silver Spring, MD 20993, USA Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Bone KW - Vibrations KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21251822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Biomedical+Ultrasound%2FBioresponse+to+Vibration%3A+Ultrasonic+Characterization+of+Bone+I&rft.au=Wear%2C+KA%3BRaum%2C+K&rft.aulast=Wear&rft.aufirst=KA&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vibrations; Bone; Ultrasound ER - TY - JOUR T1 - Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice AN - 21014277; 8287128 AB - 3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400ppm groups. A delayed total estrus cycle length was observed in the 400ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100ppm (18.05mg/kg/day for males and 15.02mg/kg/day for females). accreditation of laboratory animal care international JF - Food and Chemical Toxicology AU - Cho, W S AU - Han, B S AU - Lee, H AU - Kim, C AU - Nam, K T AU - Park, K AU - Choi, M AU - Kim, S J AU - Kim, SH AU - Jeong, J AU - Jang, D D AD - Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Korea FDA, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Republic of Korea, ddjang@kfda.go.kr Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1666 EP - 1673 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 5 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Food processing KW - Testes KW - Laboratory animals KW - Sperm KW - Toxicity KW - Food contamination KW - Cancer KW - Motility KW - Kidney KW - Degeneration KW - Epithelium KW - Ovaries KW - Body weight gain KW - Drinking water KW - Estrus cycle KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21014277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Subchronic+toxicity+study+of+3-monochloropropane-1%2C2-diol+administered+by+drinking+water+to+B6C3F1+mice&rft.au=Cho%2C+W+S%3BHan%2C+B+S%3BLee%2C+H%3BKim%2C+C%3BNam%2C+K+T%3BPark%2C+K%3BChoi%2C+M%3BKim%2C+S+J%3BKim%2C+SH%3BJeong%2C+J%3BJang%2C+D+D&rft.aulast=Cho&rft.aufirst=W&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=1666&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.12.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Food processing; Laboratory animals; Toxicity; Sperm; Food contamination; Cancer; Motility; Kidney; Epithelium; Degeneration; Ovaries; Drinking water; Body weight gain; Estrus cycle DO - http://dx.doi.org/10.1016/j.fct.2007.12.030 ER - TY - JOUR T1 - Underimmunization of American Indian and Alaska Native Children AN - 20972430; 8202783 AB - OBJECTIVE. The goal was to determine whether disparities in childhood immunization coverage exist between American Indian/Alaska Native children and non-Hispanic white children. METHODS. We compared immunization coverage with the 4 diphtheria-tetanus-pertussis, 3 poliovirus, 1 measles-mumps-rubella, 3 Haemophilus influenza type b, and 3 hepatitis B(4:3:1:3:3) series and its individual vaccine components ( greater than or equal to 4 doses of diphtheria, tetanus, and pertussis vaccine; greater than or equal to 3 doses of oral or inactivated polio vaccine; greater than or equal to 1 dose of measles, mumps, and rubella vaccine; greater than or equal to 3 doses of Haemophilus influenzae type b vaccine; and greater than or equal to 3 doses of hepatitis B vaccine) between American Indian/Alaska Native children and non-Hispanic white children from 2000 to 2005, using data from the National Immunization Survey. RESULTS. Although immunization coverage increased for both populations from 2001 to 2004, American Indian/Alaska Native children had significantly lower immunization coverage, compared with non-Hispanic white children, over that time period. In 2005, coverage continued to increase for American Indian/Alaska Native children but decreased for non-Hispanic white children, and no statistically significant disparity in 4:3:1:3:3 coverage was evident in that year. CONCLUSIONS. Disparities in immunization coverage for American Indian/Alaska Native children have been present, but unrecognized, since 2001. The absence of a disparity in coverage in 2005 is encouraging but is tempered by the fact that coverage for non-Hispanic white children decreased in that year. JF - Pediatrics AU - Groom, Amy V AU - Washington, Michael L AU - Smith, Philip J AU - Bryan, Ralph T AD - Immunization Services Division, National Center for Immunization and Respiratory Diseases. Office of Minority Health and Health Disparities, Office of Strategy and Innovation, Office of the Director, Centers for Disease Control and Prevention, Atlanta, Georgia. Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service, Albuquerque, New Mexico Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 938 EP - 944 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 5 SN - 0031-4005, 0031-4005 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Haemophilus influenzae KW - Data processing KW - Measles KW - Statistical analysis KW - Poliovirus 1 KW - Diphtheria KW - Tetanus KW - Children KW - Rubella KW - Immunization KW - Influenza KW - Hepatitis B KW - Vaccines KW - Mumps KW - J 02400:Human Diseases KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20972430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Underimmunization+of+American+Indian+and+Alaska+Native+Children&rft.au=Groom%2C+Amy+V%3BWashington%2C+Michael+L%3BSmith%2C+Philip+J%3BBryan%2C+Ralph+T&rft.aulast=Groom&rft.aufirst=Amy&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Data processing; Measles; Statistical analysis; Diphtheria; Children; Tetanus; Rubella; Immunization; Influenza; Hepatitis B; Vaccines; Mumps; Haemophilus influenzae; Poliovirus 1 ER - TY - JOUR T1 - Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum AN - 20962385; 8225920 AB - Aims:To investigate the effect of Aloe vera whole leaf extract on pure and mixed human gut bacterial cultures by assessing the bacterial growth and changes in the production of short chain fatty acids. Methods and Results:Bacteroides fragilis, Bifidobacterium infantis, and Eubacterium limosum were incubated with Aloe vera extracts [0%, 0.5%, 1%, 1.5% and 2%; (w-v)] for 24 and 48h. Short chain fatty acids production was measured by gas chromatography-mass spectrometry analyses. A significant linear increase in growth response to Aloe vera supplementation was observed at 24h for each of the bacterial cultures; however, only B. infantis and a mixed bacterial culture showed a significant positive linear dose response in growth at 48h. In pure bacteria cultures, a significantly enhanced dose response to Aloe vera supplementation was observed in the production of acetic acid by B. infantis at 24h and of butyric acid by E. limosum at 24 and 48h. In the mixed bacterial culture, the production of propionic acid was reduced significantly at 24 and 48h in a dose-dependent fashion, whereas butyric acid production showed a significant linear increase. Conclusions:The results indicated that Aloe vera possessed bacteriogenic activity in vitro and altered the production of acetic, butyric and propionic acids by micro-organisms selected for the study. Significance and Impact of the Study:The results of the study suggest that consumption of a dietary supplement, Aloe vera, may alter the production of short chain fatty acids by human intestinal microflora. JF - Letters in Applied Microbiology AU - Pogribna, M AU - Freeman, J P AU - Paine, D AU - Boudreau, MD AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA, mary.boudreau@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 575 EP - 580 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Aloe vera KW - bacteria KW - intestine KW - short chain fatty acids KW - Bacteroides fragilis KW - Propionic acid KW - Leaves KW - Acetic acid KW - Mass spectroscopy KW - Intestinal microflora KW - Aloe vera KW - Bifidobacterium infantis KW - Digestive tract KW - Gas chromatography KW - Dietary supplements KW - Fatty acids KW - Eubacterium limosum KW - Butyric acid KW - J 02330:Biochemistry KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Effect+of+Aloe+vera+whole+leaf+extract+on+short+chain+fatty+acids+production+by+Bacteroides+fragilis%2C+Bifidobacterium+infantis+and+Eubacterium+limosum&rft.au=Pogribna%2C+M%3BFreeman%2C+J+P%3BPaine%2C+D%3BBoudreau%2C+MD&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=1472-765X&rft_id=info:doi/10.1111%2Fj.1472-765X.2008.02346.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Intestinal microflora; Digestive tract; Gas chromatography; Dietary supplements; Leaves; Propionic acid; Fatty acids; Acetic acid; Mass spectroscopy; Butyric acid; Bacteroides fragilis; Aloe vera; Bifidobacterium infantis; Eubacterium limosum DO - http://dx.doi.org/10.1111/j.1472-765X.2008.02346.x ER - TY - JOUR T1 - Modeling the inactivation kinetics of bacillus spores by glutaraldehyde AN - 20943687; 8225932 AB - Aims:Our goal was to develop a mathematical kinetic model to predict the sporicidal activity of glutaraldehyde, which is an active ingredient frequently used in commercial products employed for liquid disinfection and decontamination. Methods and Results:We used our previously published data on spore inactivation by glutaraldehyde to develop a predictive model obtained by calculating multiple independent modifying functions. The model was then validated by comparing model predicted values to new experimental data. For model validation, quality-controlled spores of Bacillus athrophaeus (previously and generally known as Bacillus subtilis globigii) were exposed under conditions where several physicochemical variables were modified simultaneously, and the spore surviving fractions were measured by titration. Conclusions:The model predicted within one order of magnitude variations in sporicidal effectiveness due to changes in main parameters (glutaraldehyde concentration, temperature or time-duration of the treatment). Other parameters such pH, salinity and the effect of serum concentration were also addressed, albeit with less accuracy. Significance and Impact of the study:The model should be useful to quantitatively estimate the effectiveness of glutaraldehyde-based disinfectants, decontaminants, and germicides under the described conditions, particularly when limited data are available or when spore virulence (like that of Bacillus anthracis) precludes extensive experimentation. A similar approach could predict the effectiveness of a variety of decontaminant and disinfecting agents. JF - Letters in Applied Microbiology AU - Retta, S M AU - Sagripanti, J-L AD - Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA, joseluis.sagripanti@us.army.mil Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 568 EP - 574 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacillus KW - decontamination KW - disinfection KW - glutaraldehyde KW - spore KW - Temperature effects KW - Disinfection KW - Bacillus subtilis KW - Mathematical models KW - Decontamination KW - Bacillus anthracis KW - Models KW - Virulence KW - Disinfectants KW - Salinity effects KW - Kinetics KW - Titration KW - Germicides KW - Glutaraldehyde KW - Spores KW - pH effects KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20943687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Modeling+the+inactivation+kinetics+of+bacillus+spores+by+glutaraldehyde&rft.au=Retta%2C+S+M%3BSagripanti%2C+J-L&rft.aulast=Retta&rft.aufirst=S&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=1472-765X&rft_id=info:doi/10.1111%2Fj.1472-765X.2008.02358.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Disinfection; Mathematical models; Decontamination; Models; Virulence; Disinfectants; Kinetics; Salinity effects; Titration; Germicides; Spores; Glutaraldehyde; pH effects; Bacillus subtilis; Bacillus anthracis DO - http://dx.doi.org/10.1111/j.1472-765X.2008.02358.x ER - TY - JOUR T1 - Neural Network-Based Evaluation of Chronic Non-Thermal Effects of Modulated 2450 MHz Microwave Radiation on Electroencephalogram AN - 208948454; 18259868 AB - The effects of chronic exposure (2 h daily for 21 days) of 1 kHz square wave-modulated 2450 MHz microwave radiation (non-thermal) on sleep-EEG, open field behavior, and thyroid hormones (T3, T4, and TSH) have been analyzed in an animal model. Results revealed significant changes in these pathophysiological parameters (p < 0.05 or better), except body temperature, grooming behavior, and TSH levels. The sleep-EEG power spectrum data for slow wave sleep (SWS), rapid eye movement (REM) sleep, and awake (AWA) states in two experimental groups of rats (microwave exposed and the control) were tested by an artificial neural network (ANN), containing 60 nodes in input layer, weighted from power spectrum data from 0 to 30 Hz, 18 nodes in hidden layer and an output node. The target output values for this network were determined with another five-layered neural network (with the structure of 6-14-1-14-6). The input and output of this network was assigned with the six confirmed pathophysiological changes. The most important feature for chronic exposure of 2450 MHz microwave exposure and for control subjects was extracted from the third layer single neuron and used as the target value for the three-layered ANN. The network was found effective in recognizing the EEG power spectra with an average of 71.93% for microwave exposure and 93.13% for control subjects, respectively. However, the lower percentage of pattern identification agreement in the microwave-exposed group in comparison to the control group suggest only mild effects of microwave exposure with this experimental setup. JF - Annals of Biomedical Engineering AU - Sinha, Rakesh Kumar AU - Aggarwal, Yogender AU - Upadhyay, Prabhat Kumar AU - Dwivedi, Anjana AU - Keshri, Anup Kumar AU - Das, Barda Nand Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 839 EP - 51 CY - New York PB - Springer Science & Business Media VL - 36 IS - 5 SN - 00906964 KW - Medical Sciences KW - Rats KW - Radiation Dosage KW - Hot Temperature KW - Animals KW - Diagnosis, Computer-Assisted -- methods KW - Computer Simulation KW - Models, Neurological KW - Dose-Response Relationship, Radiation KW - Electroencephalography -- methods KW - Male KW - Sleep -- physiology KW - Sleep -- radiation effects KW - Microwaves KW - Neural Networks (Computer) KW - Brain -- radiation effects KW - Brain -- physiology KW - Electroencephalography -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/208948454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Neural+Network-Based+Evaluation+of+Chronic+Non-Thermal+Effects+of+Modulated+2450+MHz+Microwave+Radiation+on+Electroencephalogram&rft.au=Sinha%2C+Rakesh+Kumar%3BAggarwal%2C+Yogender%3BUpadhyay%2C+Prabhat+Kumar%3BDwivedi%2C+Anjana%3BKeshri%2C+Anup+Kumar%3BDas%2C+Barda+Nand&rft.aulast=Sinha&rft.aufirst=Rakesh&rft.date=2008-05-01&rft.volume=36&rft.issue=5&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-008-9450-y LA - English DB - ProQuest Central N1 - Copyright - Biomedical Engineering Society 2008 N1 - Last updated - 2014-08-30 DO - http://dx.doi.org/10.1007/s10439-008-9450-y ER - TY - JOUR T1 - Macrophage Proinflammatory Response to Francisella tularensis Live Vaccine Strain Requires Coordination of Multiple Signaling Pathways AN - 20894124; 8200913 AB - The macrophage proinflammatory response to Francisella tularensis (Ft) live vaccine strain (LVS) was shown previously to be TLR2 dependent. The observation that intracellular Ft LVS colocalizes with TLR2 and MyD88 inside macrophages suggested that Ft LVS might signal from within the phagosome. Macrophages infected with LVS Delta iglC, a Ft LVS mutant that fails to escape from the phagosome, displayed greatly increased expression of a subset of TLR2-dependent, proinflammatory genes (e.g., Tnf) but decreased expression of others (e.g., Ifnb1). This latter subset was similarly mitigated in IFN- beta super(-/-) macrophages indicating that while Ft LVS-induced TLR2 signaling is necessary, cytosolic sensing of Ft to induce IFN- beta is required for full induction of the macrophage proinflammatory response. Although LVS Delta iglC greatly increased IL-1 beta mRNA in wild-type macrophages, protein secretion was not observed. IL-1 beta secretion was also diminished in Ft LVS-infected IFN- beta super(-/-) macrophages. rIFN- beta failed to restore IL-1 beta secretion in LVS Delta iglC-infected macrophages, suggesting that signals in addition to IFN- beta are required for assembly of the inflammasome and activation of caspase-1. IFN- beta plays a central role in controlling the macrophage bacterial burden: bacterial recovery was greater in IFN- beta super(-/-) than in wild-type macrophages and treatment of Ft LVS-infected macrophages with rIFN- beta or 5,6-dimethylxanthenone-4-acetic acid, a potent IFN- beta inducer, greatly decreased the intracellular Ft LVS burden. In toto, these observations support the hypothesis that the host inflammatory response to Ft LVS is complex and requires engagement of multiple signaling pathways downstream of TLR2 including production of IFN- beta via an unknown cytosolic sensor and activation of the inflammasome. JF - Journal of Immunology AU - Cole, Leah E AU - Santiago, Araceli AU - Barry, Eileen AU - Kang, Tae Jin AU - Shirey, Kari Ann AU - Roberts, Zachary J AU - Elkins, Karen L AU - Cross, Alan S AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology and. Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research/Food and Drug Administration, Bethesda, MD 20852 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 6885 EP - 6891 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - beta -Interferon KW - Macrophages KW - MyD88 protein KW - Tumor necrosis factor KW - Phagosomes KW - Interleukin 1 KW - TLR2 protein KW - Francisella tularensis KW - Cell activation KW - mRNA KW - Inflammation KW - Caspase-1 KW - Vaccines KW - Toll-like receptors KW - Signal transduction KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20894124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Macrophage+Proinflammatory+Response+to+Francisella+tularensis+Live+Vaccine+Strain+Requires+Coordination+of+Multiple+Signaling+Pathways&rft.au=Cole%2C+Leah+E%3BSantiago%2C+Araceli%3BBarry%2C+Eileen%3BKang%2C+Tae+Jin%3BShirey%2C+Kari+Ann%3BRoberts%2C+Zachary+J%3BElkins%2C+Karen+L%3BCross%2C+Alan+S%3BVogel%2C+Stefanie+N&rft.aulast=Cole&rft.aufirst=Leah&rft.date=2008-05-01&rft.volume=180&rft.issue=10&rft.spage=6885&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; beta -Interferon; MyD88 protein; Tumor necrosis factor; TLR2 protein; Interleukin 1; Phagosomes; Inflammation; mRNA; Cell activation; Caspase-1; Vaccines; Toll-like receptors; Signal transduction; Francisella tularensis ER - TY - JOUR T1 - Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver AN - 20852403; 8307009 AB - When adenovirus (Ad) vectors are injected intravenously they are rapidly taken up by Kupffer cells (KCs) in the liver. This results in massive KC necrosis within minutes, followed by a more gradual disappearance of KCs from the liver. It is not known how KCs recognize Ad, or why Ad kills KCs. We used a variety of mutated and fiber-pseudotyped Ad vectors to evaluate how capsid proteins influence Ad uptake by KCs and to define the viral proteins that are involved in the destruction of KCs. We found that depletion of KCs from the liver was partially dependent on interactions between Ad and integrins, but was independent of the cox-sackievirus and Ad receptor. The Ad5 fiber shaft was proven to be a particularly important contributory factor, because vectors with the shorter Ad35 shaft were not as effective at depleting KCs. In contrast, the fiber head played no discernible role. Variations in the ability of Ad vectors to deplete KCs could not be explained by differences in the amount of Ad that reached KCs, because all mutant Ads were accumulated by KCs at similar levels. Interestingly, we found that the Ad mutant ts1 did not cause KC death; this virus is known to bind and enter cells normally, but the capsid is unable to disassemble or lyse membranes. We conclude that Ad vectors kill KCs at a postbinding step and that this cell death can be mitigated if downstream events in viral entry are blocked. JF - Human Gene Therapy AU - Smith, J S AU - Xu, Z AU - Tian, J AU - Stevenson, S C AU - Byrnes, A P AD - Division of Cellular and Gene Therapies, Food and Drug Administration, CBER, Building 29B, Room 2E20, HFM-725, Bethesda, MD 20892, USA, Andrew.Byrnes@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 547 EP - 554 VL - 19 IS - 5 SN - 1043-0342, 1043-0342 KW - Immunology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Capsids KW - Head KW - Gene therapy KW - Hepatocytes KW - Adenovirus KW - Expression vectors KW - Fibers KW - Kupffer cells KW - Cell death KW - Necrosis KW - Integrins KW - Liver KW - Capsid protein KW - W 30905:Medical Applications KW - V 22320:Replication KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20852403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Interaction+of+Systemically+Delivered+Adenovirus+Vectors+with+Kupffer+Cells+in+Mouse+Liver&rft.au=Smith%2C+J+S%3BXu%2C+Z%3BTian%2C+J%3BStevenson%2C+S+C%3BByrnes%2C+A+P&rft.aulast=Smith&rft.aufirst=J&rft.date=2008-05-01&rft.volume=19&rft.issue=5&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Capsids; Expression vectors; Kupffer cells; Fibers; Necrosis; Cell death; Gene therapy; Head; Integrins; Hepatocytes; Liver; Capsid protein; Adenovirus DO - http://dx.doi.org/10.1089/hum.2008.004 ER - TY - JOUR T1 - Vaccine-Elicited 10-Kilodalton Culture Filtrate Protein-Specific CD8 super(+) T Cells Are Sufficient To Mediate Protection against Mycobacterium tuberculosis Infection AN - 20846411; 8198749 AB - The 10-kDa culture filtrate protein (CFP-10) and 6-kDa early secretory antigen of T cells (ESAT-6) are secreted in abundance by Mycobacterium tuberculosis and are frequently recognized by T cells from infected people. The genes encoding these proteins have been deleted from the genome of the vaccine strain Mycobacterium bovis bacillus Calmette-Guerin (BCG), and it is hypothesized that these proteins are important targets of protective immunity. Indeed, vaccination with ESAT-6 elicits protective CD4 super(+) T cells in C57BL/6 mice. We have previously shown that M. tuberculosis infection of C3H mice elicits CFP-10-specific CD8 super(+) and CD4 super(+) T cells. Here we demonstrate that immunization with a CFP-10 DNA vaccine stimulates a specific T-cell response only to the H-2K super(k)-restricted epitope CFP-10 sub(32-39). These CFP-10 sub(32-39)-specific CD8 super(+) cells undergo a rapid expansion and accumulate in the lung following challenge of immunized mice with aerosolized M. tuberculosis. Protective immunity is induced by CFP-10 DNA vaccination as measured by a CFU reduction in the lung and spleen 4 and 8 weeks after challenge with M. tuberculosis. These data demonstrate that CFP-10 is a protective antigen and that CFP-10 sub(32-39)-specific CD8 super(+) T cells elicited by vaccination are sufficient to mediate protection against tuberculosis. JF - Infection and Immunity AU - Wu, Ying AU - Woodworth, Joshua S AU - Shin, Daniel S AU - Morris, Sheldon AU - Behar, Samuel M AD - Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115. Laboratory of Mycobacterial Diseases and Cellular Immunology, FDA/CBER, Bethesda, Maryland 20892 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2249 EP - 2255 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Data processing KW - protective antigen KW - Spleen KW - Cell culture KW - Mycobacterium bovis KW - CD8 antigen KW - Infection KW - CD4 antigen KW - DNA vaccines KW - BCG KW - Lung KW - Colony-forming cells KW - Lymphocytes T KW - Tuberculosis KW - Histocompatibility antigen H-2 KW - ESAT-6 antigen KW - Epitopes KW - Mycobacterium tuberculosis KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20846411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Vaccine-Elicited+10-Kilodalton+Culture+Filtrate+Protein-Specific+CD8+super%28%2B%29+T+Cells+Are+Sufficient+To+Mediate+Protection+against+Mycobacterium+tuberculosis+Infection&rft.au=Wu%2C+Ying%3BWoodworth%2C+Joshua+S%3BShin%2C+Daniel+S%3BMorris%2C+Sheldon%3BBehar%2C+Samuel+M&rft.aulast=Wu&rft.aufirst=Ying&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2249&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; protective antigen; Spleen; Cell culture; CD8 antigen; Infection; CD4 antigen; DNA vaccines; Lung; BCG; Colony-forming cells; Lymphocytes T; Tuberculosis; Histocompatibility antigen H-2; ESAT-6 antigen; Epitopes; Mycobacterium bovis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Temperature measurements and determination of cavitation thresholds during High Intensity Focused Ultrasound (HIFU) Exposures in ex-vivo porcine muscle AN - 20823238; 10957044 AB - Cavitation in HIFU procedures can yield unpredictable results, particularly when the same location is targeted for more than several seconds. To study this effect, temperature rise was measured in fresh ex-vivo porcine tissue during HIFU exposures. Immediately following euthanasia, a section of back muscle (latissimus dorsi) was resected and a 50 mu m diameter fine bare wire thermocouple was placed via needle through the tissue. 825 kHz HIFU was then applied to the tissue focused at the thermocouple junction. Thirty second HIFU exposures of increasing pressure from 1-7.5 MPa were applied and the temperature rise and decay during and after sonication were recorded. B-mode imaging was used to monitor any cavitation activity during sonication. If cavitation was noted during the sonication, the sonication was repeated at the same pressure level two more times at 20 minute intervals in order to characterize the repeatability given that cavitation has occurred. The cavitation threshold of porcine muscle was determined to be between 4 and 7 MPa. Temperature traces obtained at various pressure levels demonstrated a wide range of heating profiles in fresh ex-vivo tissue due to both the occurrence of cavitation and viscous heating artifacts. JF - Journal of the Acoustical Society of America AU - Maruvada, S AU - Liu, Y AU - Herman, BA AU - Pritchard, W F AU - Harris, G R AD - U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, subha.maruvada@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Cavitation KW - Muscles KW - Pressure KW - imaging KW - Ultrasound KW - Sonication KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Temperature+measurements+and+determination+of+cavitation+thresholds+during+High+Intensity+Focused+Ultrasound+%28HIFU%29+Exposures+in+ex-vivo+porcine+muscle&rft.au=Maruvada%2C+S%3BLiu%2C+Y%3BHerman%2C+BA%3BPritchard%2C+W+F%3BHarris%2C+G+R&rft.aulast=Maruvada&rft.aufirst=S&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cavitation; Muscles; Pressure; Ultrasound; imaging; Sonication ER - TY - JOUR T1 - Recent developments in modeling and measuring scattering from trabecular bone AN - 20813182; 10959092 AB - Laboratories at the US Food and Drug Administration, the University of Paris and elsewhere have investigated scattering from trabecular bone. Recent analysis of data from 23 human femur samples in vitro suggests that the Faran Cylinder Model and the Weak Scattering Model accurately predict frequency dependence of backscatter coefficient. Shear mode conversion of incident longitudinal waves may be a significant source of scattering loss. Other recent work involves the effect of errors of attenuation measurements on backscatter coefficient estimates. Backscatter measurements must be compensated for attenuation in order to estimate backscatter coefficient. However, attenuation is often overestimated because it is often measured using phase sensitive receivers that exhibit phase cancellation artifacts. Recent analysis of data from 16 human calcaneus samples in vitro suggests that backscatter coefficient estimates that are based on phase sensitive attenuation compensation tend to overestimate 1) average magnitude of backscatter coefficient at 500 kHz by a factor of about 1.6 plus or minus 0.3 (mean plus or minus standard deviation) and 2) average exponent (n) of frequency dependence by about 0.34 plus or minus 0.12 (where backscatter coefficient is assumed to be proportional to frequency to the nth power). JF - Journal of the Acoustical Society of America AU - Wear, KA AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave, Bldg 62, Rm 3108, Silver Spring, MD 20993, USA, keith.wear@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Calcaneus KW - Data processing KW - Femur KW - Frequency dependence KW - Models KW - Bone (trabecular) KW - Standard deviation KW - Waves KW - W 30935:Food Biotechnology KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20813182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Recent+developments+in+modeling+and+measuring+scattering+from+trabecular+bone&rft.au=Wear%2C+KA&rft.aulast=Wear&rft.aufirst=KA&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Bone (trabecular); Frequency dependence; Models; Calcaneus; Standard deviation; Femur; Waves ER - TY - JOUR T1 - 3,4-Dichloropropionanilide (DCPA) Inhibits T-Cell Activation by Altering the Intracellular Calcium Concentration following Store Depletion AN - 20693908; 8204090 AB - Stimulation of T cells through the T-cell receptor results in the activation of a series of signaling pathways that leads to the secretion of interleukin (IL)-2 and cell proliferation. Influx of calcium (Ca super(2+)) from the extracellular environment, following internal Ca super(2+) store depletion, provides the elevated and sustained intracellular calcium concentration ([Ca super(2+)] sub(i)) critical for optimal T-cell activation. Our laboratory has documented that exposure to the herbicide 3,4-dichloropropionanilide (DCPA) inhibits intracellular signaling events that have one or more Ca super(2+) dependent steps. Herein we report that DCPA attenuates the normal elevated and sustained [Ca super(2+)] sub(i) that follows internal store depletion in the human leukemic Jurkat T cell line and primary mouse T cells. DCPA did not alter the depletion of internal Ca super(2+) stores when stimulated by anti-CD3 or thapsigargin demonstrating that early inositol 1,4,5-triphosphate-mediated signaling and depletion of Ca super(2+) stores were unaffected. 2-Aminoethyldiphenol borate (2-APB) is known to alter the store-operated Ca super(2+) (SOC) influx that follows Ca super(2+) store depletion. Exposure of Jurkat cells to either DCPA or 50 mu M 2-APB attenuated the increase in [Ca super(2+)] sub(i) following thapsigargin or anti-CD3 induced store depletion in a similar manner. At low concentrations, 2-APB enhances SOC influx but this enhancement is abrogated in the presence of DCPA. This alteration in [Ca super(2+)] sub(i), when exposed to DCPA, significantly reduces nuclear levels of nuclear factor of activated T cells (NFAT) and IL-2 secretion. The plasma membrane polarization profile is not altered by DCPA exposure. Taken together, these data indicate that DCPA inhibits T-cell activation by altering Ca super(2+) homeostasis following store depletion. JF - Toxicological Sciences AU - Lewis, Tricia L AU - Brundage, Kathleen M AU - Brundage, Rodney A AU - Barnett, John B AD - Department of Microbiology, Immunology and Cell Biology. Center for Immunopathology and Microbial Pathogenesis, West Virginia University School of Medicine, Morgantown, West Viginia 26506. National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Morgantown, West Viginia 26506 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 97 EP - 107 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts; Immunology Abstracts; Calcium & Calcified Tissue Abstracts KW - Intracellular signalling KW - Calcium homeostasis KW - Interleukin 2 KW - double prime T-cell receptor KW - Inositol KW - Herbicides KW - Polarization KW - Calcium (extracellular) KW - Cell activation KW - Calcium (intracellular) KW - Leukemia KW - Calcium influx KW - Plasma membranes KW - thapsigargin KW - Transcription factors KW - Lymphocytes T KW - NF-AT protein KW - Cell proliferation KW - Signal transduction KW - T 2000:Cellular Calcium KW - F 06955:Immunomodulation & Immunopharmacology KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20693908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=3%2C4-Dichloropropionanilide+%28DCPA%29+Inhibits+T-Cell+Activation+by+Altering+the+Intracellular+Calcium+Concentration+following+Store+Depletion&rft.au=Lewis%2C+Tricia+L%3BBrundage%2C+Kathleen+M%3BBrundage%2C+Rodney+A%3BBarnett%2C+John+B&rft.aulast=Lewis&rft.aufirst=Tricia&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Calcium homeostasis; Intracellular signalling; Interleukin 2; double prime T-cell receptor; Inositol; Herbicides; Polarization; Calcium (extracellular); Calcium (intracellular); Cell activation; Leukemia; Calcium influx; thapsigargin; Plasma membranes; Transcription factors; Lymphocytes T; Cell proliferation; NF-AT protein; Signal transduction ER - TY - JOUR T1 - Gestational Exposure to Perfluorooctane Sulfonate Suppresses Immune Function in B6C3F1 Mice AN - 20691195; 8204088 AB - Perfluorinated alkyl acids (PFAAs) are used in a multitude of applications and are categorized as high-production volume chemicals produced in quantities exceeding 10,000 lbs/year. As a result, widespread exposure has been documented in adults, children, and infants. It is generally accepted that children are more sensitive to the effects of xenobiotic exposures during fetal and postnatal periods of development; therefore, considerable efforts are required to investigate the potential impact of a model PFAA, perfluorooctane sulfonate (PFOS) on children's immunological health. Using the pairing of female C57BL/6N mice with male C3H/HeJ, developmental immunotoxicity was evaluated in B6C3F1 pups following oral maternal exposure to PFOS on gestations days 1-17. Exposure levels included 0.1, 1, and 5 mg/kg/day PFOS. Natural killer (NK) cell activity, SRBC IgM plaque assay, CD4/8 lymphocytic subpopulations, nitrite production in peritoneal macrophages, and body/organ weights were evaluated at 4 and 8 weeks of age in F1 pups. No significant dose-responsive changes in maternal or pup body weights, flow cytometry, or macrophage function were observed, yet hepatomegaly was indicated in F1 male pups at 4 weeks of age. Functional deficits were not evident until 8 weeks of age when NK cell function and IgM production were significantly decreased. When compared with females, male pups were more sensitive to the effects of PFOS thereby establishing a no observed adverse effect level and low observed adverse effect level of 0.1 and 1.0 mg/kg/day (males only) following maternal PFOS exposure level, respectively. This study establishes that the developing immune system is sensitive to the effects of PFOS and results in functional deficits in innate and humoral immunity detectable at adulthood. JF - Toxicological Sciences AU - Keil, Deborah E AU - Mehlmann, Tracey AU - Butterworth, Leon AU - Peden-Adams, Margie M AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Clinical Laboratory Sciences, University of Nevada, Las Vegas, Nevada 89154. Department of Pediatrics and the Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, South Carolina 29401 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 77 EP - 85 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Age KW - Immune system KW - Peritoneum KW - Natural killer cells KW - Children KW - Fetuses KW - Flow cytometry KW - Immunity (humoral) KW - CD4 antigen KW - Immunotoxicity KW - Body weight KW - Acids KW - Gestation KW - Plaque assay KW - Immune response KW - Nitrite KW - Side effects KW - Immunoglobulin M KW - Infants KW - F 06955:Immunomodulation & Immunopharmacology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20691195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Gestational+Exposure+to+Perfluorooctane+Sulfonate+Suppresses+Immune+Function+in+B6C3F1+Mice&rft.au=Keil%2C+Deborah+E%3BMehlmann%2C+Tracey%3BButterworth%2C+Leon%3BPeden-Adams%2C+Margie+M&rft.aulast=Keil&rft.aufirst=Deborah&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Age; Immune system; Peritoneum; Natural killer cells; Children; Fetuses; Immunity (humoral); Flow cytometry; Immunotoxicity; CD4 antigen; Body weight; Acids; Gestation; Plaque assay; Immune response; Nitrite; Immunoglobulin M; Side effects; Infants ER - TY - JOUR T1 - Occupation and bladder cancer in a hospital-based case-control study in Spain AN - 20690770; 8202611 AB - OBJECTIVES: We investigated the association between occupation and bladder cancer in a hospital-based case-control study conducted in Spain. METHODS: 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time occupational history, smoking habits, medical history, and other factors. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for each occupation and industry, adjusting for age, hospital region, smoking duration, and employment in a high-risk occupation for bladder cancer. RESULTS: Statistically significant increased risks were observed among men employed as machine operators in the printing industry (OR 5.4; 95% CI 1.6 to 17.7), among men employed in the transportation equipment industry (OR 1.6; 95% CI 1.1 to 2.6) and among those who had worked for greater than or equal to 10 years in the electrical/gas/sanitary services (OR 3.9; 95% CI 1.5 to 10.4) and in hotels and other lodgings (OR 3.1; 95% CI 1.3 to 7.3). Men who worked as miscellaneous mechanics and repairers (OR 2.0; 95% CI 1.1 to 3.6) and as supervisors in production occupations (OR 2.1; 95% CI 1.2 to 3.6) also had excess risks for bladder cancer. Male farmers and those who worked in crop and livestock production had decreased risks for bladder cancer. We found no significant associations between occupation or industry and bladder cancer risk among women. CONCLUSIONS: We did not observe excess bladder cancer risk for many of the occupations identified as being a priori at high risk. Examination of more detailed job exposure information should help clarify these associations. JF - Occupational and Environmental Medicine AU - Samanic, C M AU - Kogevinas, M AU - Silverman, D T AU - Tardon, A AU - Serra, C AU - Malats, N AU - Real, F X AU - Carrato, A AU - Garcia-Closas, R AU - Sala, M AU - Lloreta, J AU - Rothman, N AU - Dosemeci, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 347 EP - 353 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Spain KW - Printing industry KW - Crops KW - Cancer KW - hotels KW - Livestock KW - Smoking KW - urinary bladder KW - Transportation KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20690770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupation+and+bladder+cancer+in+a+hospital-based+case-control+study+in+Spain&rft.au=Samanic%2C+C+M%3BKogevinas%2C+M%3BSilverman%2C+D+T%3BTardon%2C+A%3BSerra%2C+C%3BMalats%2C+N%3BReal%2C+F+X%3BCarrato%2C+A%3BGarcia-Closas%2C+R%3BSala%2C+M%3BLloreta%2C+J%3BRothman%2C+N%3BDosemeci%2C+M&rft.aulast=Samanic&rft.aufirst=C&rft.date=2008-05-01&rft.volume=65&rft.issue=5&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - urinary bladder; Smoking; Historical account; Age; Transportation; Printing industry; Cancer; Crops; Occupational exposure; Livestock; hotels; Spain ER - TY - JOUR T1 - Chemical exposures at hazardous waste sites: Experiences from the United States and Poland AN - 20689260; 8178654 AB - The U.S. Agency for Toxic Substances and Disease Registry (ATSDR) and the Polish Nofer Institute of Occupational Health collaborate on issues related to hazardous chemical exposure at or near hazardous waste sites. This paper outlines the scope of hazardous chemical exposure in the United States and in Poland and identifies priority chemicals and chemical mixtures. Special attention is paid to exposures to metals and to evaluation of the health risks associated with those exposures. Studies in the United States indicate that exposure to hazardous waste site chemicals may be associated with an increased risk of adverse developmental - specifically cardiovascular and neurodevelopmental - effects. JF - Environmental Toxicology and Pharmacology AU - Pohl, H R AU - Tarkowski, S AU - Buczynska, A AU - Fay, M AU - De Rosa, CT AD - US Department of Health and Human Services, Atlanta, GA, USA, hpohl@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 283 EP - 291 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 3 SN - 1382-6689, 1382-6689 KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Chemicals KW - Metals KW - Cardiovascular system KW - USA KW - Poland KW - Neurotoxicity KW - Waste disposal sites KW - Hazardous wastes KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20689260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Chemical+exposures+at+hazardous+waste+sites%3A+Experiences+from+the+United+States+and+Poland&rft.au=Pohl%2C+H+R%3BTarkowski%2C+S%3BBuczynska%2C+A%3BFay%2C+M%3BDe+Rosa%2C+CT&rft.aulast=Pohl&rft.aufirst=H&rft.date=2008-05-01&rft.volume=25&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metals; Waste disposal sites; Occupational exposure; Chemicals; Cardiovascular system; Neurotoxicity; Hazardous wastes; Occupational health; USA; Poland DO - http://dx.doi.org/10.1016/j.etap.2007.12.005 ER - TY - JOUR T1 - Estimating Consumer Familiarity with Health Terminology: A Context-based Approach AN - 20673332; 8199215 AB - OBJECTIVES: Effective health communication is often hindered by a "vocabulary gap" between language familiar to consumers and jargon used in medical practice and research. To present health information to consumers in a comprehensible fashion, we need to develop a mechanism to quantify health terms as being more likely or less likely to be understood by typical members of the lay public. Prior research has used approaches including syllable count, easy word list, and frequency count, all of which have significant limitations. DESIGN: In this article, we present a new method that predicts consumer familiarity using contextual information. The method was applied to a large query log data set and validated using results from two previously conducted consumer surveys. MEASUREMENTS: We measured the correlation between the survey result and the context-based prediction, syllable count, frequency count, and log normalized frequency count. RESULTS: The correlation coefficient between the context-based prediction and the survey result was 0.773 (p < 0.001), which was higher than the correlation coefficients between the survey result and the syllable count, frequency count, and log normalized frequency count (p less than or equal to 0.012). CONCLUSIONS: The context-based approach provides a good alternative to the existing term familiarity assessment methods. JF - Journal of the American Medical Informatics Association AU - Zeng-Treitler, Qing AU - Goryachev, Sergey AU - Tse, Tony AU - Keselman, Alla AU - Boxwala, Aziz AD - Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, MD. Aquilent, Inc., Laurel, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 349 EP - 356 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 3 SN - 1067-5027, 1067-5027 KW - Biotechnology Research Abstracts (through 1992) KW - Communication KW - Language KW - Consumers KW - Familiarity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20673332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Estimating+Consumer+Familiarity+with+Health+Terminology%3A+A+Context-based+Approach&rft.au=Zeng-Treitler%2C+Qing%3BGoryachev%2C+Sergey%3BTse%2C+Tony%3BKeselman%2C+Alla%3BBoxwala%2C+Aziz&rft.aulast=Zeng-Treitler&rft.aufirst=Qing&rft.date=2008-05-01&rft.volume=15&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Consumers; Familiarity; Language; Communication ER - TY - JOUR T1 - Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors AN - 20668629; 8198740 AB - The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mechanisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced immunity have been less well studied and defined. We used a combination of complement depletion along with immunodeficient mice and adoptive transfer approaches to determine the mechanisms of infection-induced protective immunity to B. anthracis. B- or T-cell-deficient mice lacked the complete anamnestic protection observed in immunocompetent mice. In addition, T-cell-deficient mice generated poor antibody titers but were protected by the adoptive transfer of serum from B. anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors. Together, these results indicate that antibody-mediated neutralization provides significant protection in B. anthracis infection-induced immunity. JF - Infection and Immunity AU - Harvill, Eric T AU - Osorio, Manuel AU - Loving, Crystal L AU - Lee, Gloria M AU - Kelly, Vanessa K AU - Merkel, Tod J AD - Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2177 EP - 2182 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Antibodies KW - double prime Fc receptors KW - Lymphocytes T KW - Adoptive transfer KW - Immunodeficiency KW - Immunity KW - Vaccines KW - Bacillus anthracis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Anamnestic+Protective+Immunity+to+Bacillus+anthracis+Is+Antibody+Mediated+but+Independent+of+Complement+and+Fc+Receptors&rft.au=Harvill%2C+Eric+T%3BOsorio%2C+Manuel%3BLoving%2C+Crystal+L%3BLee%2C+Gloria+M%3BKelly%2C+Vanessa+K%3BMerkel%2C+Tod+J&rft.aulast=Harvill&rft.aufirst=Eric&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2177&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; double prime Fc receptors; Immunodeficiency; Adoptive transfer; Lymphocytes T; Vaccines; Immunity; Bacillus anthracis ER - TY - JOUR T1 - Implementing infrared determination of quartz particulates on novel filters for a prototype dust monitor AN - 20249442; 8270752 AB - Research by the National Institute for Occupational Safety and Health (NIOSH) has pursued quartz analysis for the specialized filter assemblies of a new worker-wearable personal dust monitor (PDM). The PDM is a real-time instrument utilizing a tapered element oscillating microbalance (TEOM+). Standard fiberglass TEOM filters cannot accommodate the desired P-7 infrared analytical method used by the Mine Safety and Health Administration (MSHA). Novel filter materials were tested with the objective of demonstrating this type of analysis. Low temperature ashing and spectrometric examination were employed, revealing that nylon fiber candidate filters left minimal residual ash and produced no significant spectral interference. Avoiding titanium dioxide in all filter materials proved to be a key requirement. Fine quartz particulates were collected on prototype filters in a Marple chamber, either open-faced or through PDMs during test runs. The filters were then subjected to MSHA P-7 analysis and the spectrometrically based analytical results for quartz mass were compared to reference measurements. Also, PDM instrumental mass readings were compared to filter gravimetric measurements. Results suggest that the P-7 method is adaptable to variations in filter materials and that quartz dust analysis by the P-7 method when utilizing the new ashable PDM filters can have accuracy and precision within 10% and 4%, respectively. This is within the declared 13% accuracy and 7-10% precision of the P-7 method itself. Instrument mass readings had modest positive bias but met NIOSH accuracy criteria. Continued work with specialized PDM filters is merited, as they are a new type of TEOM sample amenable to ashing analysis of particulates. JF - Journal of Environmental Monitoring AU - Tuchman, D P AU - Volkwein, J C AU - Vinson, R P AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA, 15236, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 671 EP - 678 VL - 10 IS - 5 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Filters KW - Safety regulations KW - titanium dioxide KW - prototypes KW - Fiberglass KW - Ash KW - Occupational safety KW - low temperature KW - Particulates KW - Dust KW - Monitoring instruments KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20249442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Implementing+infrared+determination+of+quartz+particulates+on+novel+filters+for+a+prototype+dust+monitor&rft.au=Tuchman%2C+D+P%3BVolkwein%2C+J+C%3BVinson%2C+R+P&rft.aulast=Tuchman&rft.aufirst=D&rft.date=2008-05-01&rft.volume=10&rft.issue=5&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb803804j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Filters; Safety regulations; titanium dioxide; Ash; Fiberglass; prototypes; Occupational safety; low temperature; Particulates; Dust; Monitoring instruments DO - http://dx.doi.org/10.1039/b803804j ER - TY - JOUR T1 - Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue AN - 20241936; 8867014 AB - Ferric hexacyanoferrate (Fe sub(4) super(III)[Fe super(II)(CN) sub(6)] sub(3)), also known as insoluble Prussian blue (PB) is the active pharmaceutical ingredient (API) of the drug product, Radiogardase. Radiogardase is the first FDA approved medical countermeasure for the treatment of internal contamination with radioactive cesium (Cs) or thallium in the event of a major radiological incident such as a "dirty bomb". A number of pre-clinical and clinical studies have evaluated the use of PB as an investigational decorporation agent to enhance the excretion of metal cations. There are few sources of published in vitro data that detail the binding capacity of cesium to insoluble PB under various chemical and physical conditions. The study objective was to determine the in vitro binding capacity of PB APIs and drug products by evaluating certain chemical and physical factors such as medium pH, particle size, and storage conditions (temperature). In vitro experimental conditions ranged from pH 1 to 9, to cover the range of pH levels that PB may encounter in the gastrointestinal (GI) tract in humans. Measurements of cesium binding were made between 1 and 24 h, to cover gastric and intestinal tract residence time using a validated atomic emission spectroscopy (AES) method. The results indicated that pH, exposure time, storage temperature (affecting moisture content) and particle size play significant roles in the cesium binding to both the PB API and the drug product. The lowest cesium binding was observed at gastric pH of 1 and 2, whereas the highest cesium binding was observed at physiological pH of 7.5. It was observed that dry storage conditions resulted in a loss of moisture from PB, which had a significant negative effect on the PB cesium binding capacity at time intervals consistent with gastric residence. Differences were also observed in the binding capacity of PB with different particle sizes. Significant batch to batch differences were also observed in the binding capacity of some PB API and drug products. Our results suggest that certain physiochemical properties affect the initial binding capacity and the overall binding capacity of PB APIs and drug products during conditions that simulated gastric and GI residence time. These physiochemical properties can be utilized as quality attributes to monitor and predict drug product quality under certain manufacturing and storage conditions and may be utilized to enhance the clinical efficacy of PB. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Faustino, Patrick J AU - Yang, Yongsheng AU - Progar, Joseph J AU - Brownell, Charles R AU - Sadrieh, Nakissa AU - May, Joan C AU - Leutzinger, Eldon AU - Place, David A AU - Duffy, Eric P AU - Houn, Florence AU - Loewke, Sally A AU - Mecozzi, Vincent J AU - Ellison, Christopher D AU - Khan, Mansoor A AU - Hussain, Ajaz S AU - Lyon, Robbe C AD - Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States, patrick.faustino@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 114 EP - 125 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 47 IS - 1 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Prussian blue KW - Cesium binding KW - pH-profile KW - GI model KW - Particle size KW - Moisture KW - Atomic emission spectroscopy KW - Product quality KW - Temperature effects KW - Data processing KW - Cesium KW - Contamination KW - Heavy metals KW - Drug development KW - Spectroscopy KW - Cations KW - Storage conditions KW - Apis KW - Intestine KW - Pharmaceuticals KW - Excretion KW - Thallium KW - Gastrointestinal tract KW - Drugs KW - pH effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Quantitative+determination+of+cesium+binding+to+ferric+hexacyanoferrate%3A+Prussian+blue&rft.au=Faustino%2C+Patrick+J%3BYang%2C+Yongsheng%3BProgar%2C+Joseph+J%3BBrownell%2C+Charles+R%3BSadrieh%2C+Nakissa%3BMay%2C+Joan+C%3BLeutzinger%2C+Eldon%3BPlace%2C+David+A%3BDuffy%2C+Eric+P%3BHoun%2C+Florence%3BLoewke%2C+Sally+A%3BMecozzi%2C+Vincent+J%3BEllison%2C+Christopher+D%3BKhan%2C+Mansoor+A%3BHussain%2C+Ajaz+S%3BLyon%2C+Robbe+C&rft.aulast=Faustino&rft.aufirst=Patrick&rft.date=2008-05-01&rft.volume=47&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2007.11.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Particle size; Temperature effects; Cesium; Data processing; Contamination; Heavy metals; Drug development; Spectroscopy; Cations; Storage conditions; Intestine; Pharmaceuticals; Thallium; Excretion; Gastrointestinal tract; pH effects; Drugs; Apis DO - http://dx.doi.org/10.1016/j.jpba.2007.11.049 ER - TY - JOUR T1 - Test early for verotoxin producing Escherichia coli AN - 20105034; 8300599 JF - British Medical Journal AU - Salmon, Roland L AU - Evans, Meirion R AU - Mason, Brendan W AU - Werber, Dirk AD - National Public Health Service for Wales, Temple of Peace and Health, Cardiff CF10 3NW Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1147 EP - 1148 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 336 IS - 7654 SN - 0959-8138, 0959-8138 KW - Microbiology Abstracts B: Bacteriology KW - verotoxin KW - Escherichia coli KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20105034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Test+early+for+verotoxin+producing+Escherichia+coli&rft.au=Salmon%2C+Roland+L%3BEvans%2C+Meirion+R%3BMason%2C+Brendan+W%3BWerber%2C+Dirk&rft.aulast=Salmon&rft.aufirst=Roland&rft.date=2008-05-01&rft.volume=336&rft.issue=7654&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - verotoxin; Escherichia coli ER - TY - JOUR T1 - Effect of Gaseous Chlorine Dioxide on Indoor Microbial Contaminants AN - 19896322; 8380069 AB - Traditional and modern techniques for bioaerosol enumeration were used to evaluate the relative efficiency of gaseous chlorine dioxide (ClO2) in reducing the indoor microbial contamination under field and laboratory conditions. The field study was performed in a highly microbially contaminated house, which had had an undetected roof leak for an extended period of time and exhibited large areas of visible microbial growth. Air concentrations of culturable fungi and bacteria, total fungi determined by microscopic count and polymerase chain reaction (PCR) assays, endotoxin, and (1-3)-B-D-glucan were determined before and after the house was tented and treated with ClO2. The laboratory study was designed to evaluate the efficiency of ClO2 treatment against known concentrations of spores of Aspergillus versicolor and Stachybotrys chartarum on filter paper (surrogate for surface treatment). These species are commonly found in damp indoor environments and were detected in the field study. Upon analysis of the environmental data from the treated house, it was found that the culturable bacteria and fungi as well as total count of fungi (as determined by microscopic count and PCR) were decreased at least 85% after the ClO2 application. However, microscopic analyses of tape samples collected from surfaces after treatment showed that the fungal structures were still present on surfaces. There was no statistically significant change in airborne endotoxin and (1-3)-B-D-glucan concentration in the field study. The laboratory study supported these results and showed a nonsignificant increase in the concentration of (1-3)-B-D-glucan after ClO2 treatment. JF - Journal of the Air & Waste Management Association AU - Burton, N C AU - Adhikari, A AU - Iosslfova, Y AU - Grinshpun, SA AU - Reponen, T AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, and Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 58 IS - 5 SN - 1096-2247, 1096-2247 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts KW - Endotoxins KW - Houses KW - Data processing KW - Housing KW - Contamination KW - Fungi KW - Aspergillus versicolor KW - Airborne microorganisms KW - Statistical analysis KW - Chlorine KW - Stachybotrys chartarum KW - Microbial contamination KW - Filters KW - Chlorine dioxide KW - Residential areas KW - Filter paper KW - Polymerase chain reaction KW - Indoor environments KW - Contaminants KW - Spores KW - P 0000:AIR POLLUTION KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+Gaseous+Chlorine+Dioxide+on+Indoor+Microbial+Contaminants&rft.au=Burton%2C+N+C%3BAdhikari%2C+A%3BIosslfova%2C+Y%3BGrinshpun%2C+SA%3BReponen%2C+T&rft.aulast=Burton&rft.aufirst=N&rft.date=2008-05-01&rft.volume=58&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Chlorine dioxide; Houses; Data processing; Contamination; Fungi; Filter paper; Statistical analysis; Polymerase chain reaction; Spores; Contaminants; Filters; Housing; Airborne microorganisms; Residential areas; Chlorine; Microbial contamination; Indoor environments; Aspergillus versicolor; Stachybotrys chartarum ER - TY - JOUR T1 - Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR AN - 19891617; 8204083 AB - The liver-specific importer organic anion transporting polypeptide 1b2 (Oatp1b2, Slco1b2, also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3 transport a large variety of chemicals. Oatp1b2-null mice were engineered by homologous recombination and their phenotype was characterized. Oatp1b2 protein was absent in livers of Oatp1b2-null mice. Oatp1b2-null mice develop normally and breed well. However, adult Oatp1b2-null mice had moderate conjugated hyperbilirubinemia. Compared with wild-types, Oatp1b2-null mice had similar hepatic messenger RNA expression of most transporters examined except a higher Oatp1a4 but lower organic anion transporter 2. Intra-arterial injection of the mushroom toxin phalloidin (an Oatp1b2-specific substrate identified in vitro) caused cholestasis in wild-type mice but not in Oatp1b2-null mice. Hepatic uptake of fluorescence-labeled phalloidin was absent in Oatp1b2-null mice. Three hours after administration of microcystin-LR (a blue-green algae toxin), the binding of microcystin-LR to hepatic protein phosphatase 1/2a was much lower in Oatp1b2-null mice compared with wild-type mice. In contrast, Oatp1b2-null mice were transiently protected from decrease in bile flow induced by estradiol-17 beta -D-glucuronide, a common substrate for Oatps. Oatp1b2-null mice were completely resistant to the hepatotoxicity induced by phalloidin and microcystin-LR, but were similarly sensitive to alpha -amanitin-induced hepatotoxicity compared with wild-type mice. In conclusion, Oatp1b2-null mice display altered basic physiology and markedly decreased hepatic uptake/toxicity of phalloidin and microcystin-LR. Oatp1b2-null mice are useful in elucidating the role of Oatp1b2 and its human orthologs OATP1B1/1B3 in hepatic uptake and systemic disposition of toxic chemicals and therapeutic drugs. JF - Toxicological Sciences AU - Lu, Hong AU - Choudhuri, Supratim AU - Ogura, Kenichiro AU - Csanaky, Ivan L AU - Lei, Xiaohong AU - Cheng, Xingguo AU - Song, Pei-zhen AU - Klaassen, Curtis D AD - Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas. Center for Food Safety and Nutrition, Food and Drug Administration, College Park, Maryland. Department of Drug Metabolism and Molecular Toxicology, Tokyo University of Pharmacy and Life Science, Tokyo, Japan Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 35 EP - 45 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Anions KW - Cholestasis KW - phalloidin KW - Phosphoprotein phosphatase KW - Disposition KW - Toxicity KW - Basidiocarps KW - hepatotoxicity KW - Toxins KW - organic anion transporting polypeptide KW - Gene expression KW - Cyanobacteria KW - Bile KW - Hyperbilirubinemia KW - Liver KW - Microcystin-LR KW - homologous recombination KW - Cyanophyta KW - Drugs KW - Algae KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Characterization+of+Organic+Anion+Transporting+Polypeptide+1b2-null+Mice%3A+Essential+Role+in+Hepatic+Uptake%2FToxicity+of+Phalloidin+and+Microcystin-LR&rft.au=Lu%2C+Hong%3BChoudhuri%2C+Supratim%3BOgura%2C+Kenichiro%3BCsanaky%2C+Ivan+L%3BLei%2C+Xiaohong%3BCheng%2C+Xingguo%3BSong%2C+Pei-zhen%3BKlaassen%2C+Curtis+D&rft.aulast=Lu&rft.aufirst=Hong&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anions; Cholestasis; Phosphoprotein phosphatase; phalloidin; Disposition; Toxicity; Basidiocarps; organic anion transporting polypeptide; Toxins; hepatotoxicity; Gene expression; Hyperbilirubinemia; Bile; Liver; Microcystin-LR; homologous recombination; Drugs; Algae; Cyanobacteria; Cyanophyta ER - TY - JOUR T1 - Epidemiology of Hospitalizations Associated with Ulcers, Gastric Cancers, and Helicobacter pylori Infection among American Indian and Alaska Native Persons AN - 19807977; 8761983 AB - To describe the epidemiology of ulcers, gastric cancer, and Helicobacter pylori infection among American Indian (AI) and Alaska Native (AN) persons, we analyzed hospitalization discharge records with physician discharge diagnoses coded as ulcer, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma during 1980 to 2005, and H. pylori during 1996 to 2005 from the Indian Health Service Inpatient Dataset The average annual age-adjusted rate of hospitalizations that included an ulcer-associated condition was 232.4 per 100,000 AI/AN persons. The age-adjusted rate for gastric cancer was 14.2 per 100,000 persons. MALT lymphoma was listed as a discharge diagnosis at an age-adjusted rate of 6.1 per 100,000, and the age-adjusted rate of H. pybri discharge diagnoses was 282 per 100,000. The AI/AN persons living in the Alaska region and those greater than or equal to 65 years old had the highest rates of hospitalizations that listed ulcer-associated conditions, gastric cancers, MALT lymphoma, and H. pylori as a discharge diagnosis. JF - American Journal of Tropical Medicine and Hygiene AU - Demma, L J AU - Holman, R C AU - Sobel, J AU - Yorita, K L AU - Hennessy, T W AU - Paisano, EL AU - Cheek, JE AD - Enteric Disease Epidemiology Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 811 EP - 818 VL - 78 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Epidemiology KW - Ulcers KW - Mucosal-associated lymphoid tissue KW - Gastric cancer KW - Infection KW - Lymphoma KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19807977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Epidemiology+of+Hospitalizations+Associated+with+Ulcers%2C+Gastric+Cancers%2C+and+Helicobacter+pylori+Infection+among+American+Indian+and+Alaska+Native+Persons&rft.au=Demma%2C+L+J%3BHolman%2C+R+C%3BSobel%2C+J%3BYorita%2C+K+L%3BHennessy%2C+T+W%3BPaisano%2C+EL%3BCheek%2C+JE&rft.aulast=Demma&rft.aufirst=L&rft.date=2008-05-01&rft.volume=78&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epidemiology; Ulcers; Mucosal-associated lymphoid tissue; Infection; Gastric cancer; Lymphoma; Helicobacter pylori ER - TY - JOUR T1 - Trends in Intussusception Hospitalizations Among US Infants, 1993-2004: Implications for Monitoring the Safety of the New Rotavirus Vaccination Program AN - 19794377; 8202803 AB - OBJECTIVES. In 2006, a new rotavirus vaccine was recommended for routine immunization of US infants. Because a previous rotavirus vaccine was withdrawn in 1999 after it was associated with intussusception, monitoring for this adverse event with the new vaccine is important. The objectives of this study were to assess intussusception hospitalizations trends among US infants for 1993 to 2004; provide estimates of hospitalization rates for intussusception for 2002-2004; and assess variations in background rates by age, race/ethnicity, and surgical management. METHODS. By using the Healthcare Cost and Utilization Project's State Inpatient Database that captures US hospital discharges from 16 states representing 49% of the birth cohort during 1993-2004 and from 35 states representing 85% of the birth cohort in 2002-2004, we examined hospitalizations among infants (<12 months of age) with an International Classification of Disease, Ninth Revision, Clinical Modification code for intussusception (560.0). Incidence rates were calculated by using census data, and rate ratios with 95% confidence intervals were calculated by using Poisson regression data. RESULTS. Annual intussusception hospitalization rates declined 25% from 1993 to 2004 but have remained stable at similar to 35 cases per 100000 infants since 2000. Rates were very low for infants younger than 9 weeks (<5 per 100000) then increased rapidly, peaking at similar to 62 per 100000 at 26 to 29 weeks, before declining gradually to 26 per 100000 at 52 weeks. Compared with rates among non-Hispanic white infants (27 per 100000), rates were greater among non-Hispanic black infants (37 per 100000) and Hispanic infants (45 per 100000); however, rates did not differ by race/ethnicity for infants who were younger than 16 weeks. CONCLUSIONS. This assessment of US hospitalizations provides up-to-date and nationally representative prevaccine rates of intussusception. Because rates varied almost 12-fold by week of age and to a lesser extent by race/ethnicity during the age of vaccination, adjusting baseline rates to reflect the demographics of the vaccinated population will be crucial for assessing risk for intussusception after rotavirus vaccination. JF - Pediatrics AU - Tate, Jacqueline E AU - Simonsen, Lone AU - Viboud, Cecile AU - Steiner, Claudia AU - Patel, Manish M AU - Curns, Aaron T AU - Parashar, Umesh D AD - Division of Viral Diseases, Epidemiology Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Fogarty International Center, National Institutes of Health, Bethesda, Maryland. Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2008/05// PY - 2008 DA - May 2008 SP - e1125 EP - e1132 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 5 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Rotavirus KW - census KW - vaccines KW - Age KW - Vaccination KW - immunization KW - Demography KW - Databases KW - USA KW - Health care KW - Classification KW - intussusception KW - Census KW - Vaccines KW - Side effects KW - Ethnic groups KW - Races KW - Infants KW - Hospitals KW - R2 23060:Medical and environmental health KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Trends+in+Intussusception+Hospitalizations+Among+US+Infants%2C+1993-2004%3A+Implications+for+Monitoring+the+Safety+of+the+New+Rotavirus+Vaccination+Program&rft.au=Tate%2C+Jacqueline+E%3BSimonsen%2C+Lone%3BViboud%2C+Cecile%3BSteiner%2C+Claudia%3BPatel%2C+Manish+M%3BCurns%2C+Aaron+T%3BParashar%2C+Umesh+D&rft.aulast=Tate&rft.aufirst=Jacqueline&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=e1125&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Age; Classification; intussusception; Census; Vaccines; Vaccination; Races; Ethnic groups; Hospitals; Infants; census; immunization; vaccines; Health care; Side effects; Rotavirus; USA ER - TY - JOUR T1 - The impact of operating heavy equipment vehicles on lower back disorders AN - 19614799; 8681571 AB - Literature reviews examining the relationship between heavy equipment vehicle (HEV) operation and the development of musculoskeletal disorders have generally been qualitative in nature and have not employed an evidence-based assessment procedure. This research determines the extent to which whole-body vibration/shock and working postures are associated with lower back and neck disorders among HEV operators, while accounting for individual (i.e. age, gender, prior history of back or neck disorders) and occupational (i.e. material handling, climatic conditions, psychosocial factors) confounders. Published articles were obtained from a search of electronic databases and from bibliographies in the identified articles. A critical appraisal of these articles was conducted using an epidemiological appraisal instrument (Genaidy et al. 2007). The meta-analysis was conducted using statistical techniques employing fixed-effect and random-effect models. Eighteen articles reporting observational studies satisfied the inclusion criteria adopted for this research. The methodological qualities of the published studies ranged from marginal to average. The meta-relative risk was found to be 2.21, indicating that operators exposed to driving HEVs are at more than twice the risk of developing lower back pain in comparison to those not exposed to driving HEVs. Therefore, it seems possible that there is a causal relationship between working as a HEV operator and development of lower back disorders. Prospective cohort studies are urgently needed to confirm the outcomes of this evidence-based methodology (based in part on the meta-analysis) and the biological plausibility should be further explored. The reported findings point to a need for improved ergonomic design of HEVs. JF - Ergonomics AU - Waters, Thomas AU - Genaidy, Ash AU - Viruet, Heriberto Barriera AU - Makola, Mbulelo AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 602 EP - 636 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 51 IS - 5 SN - 0014-0139, 0014-0139 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - back pain KW - musculoskeletal system KW - Bibliographies KW - Gender KW - posture KW - Age KW - Materials handling KW - climatic conditions KW - Ergonomics KW - Hepatitis E virus KW - Reviews KW - Vibration KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19614799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=The+impact+of+operating+heavy+equipment+vehicles+on+lower+back+disorders&rft.au=Waters%2C+Thomas%3BGenaidy%2C+Ash%3BViruet%2C+Heriberto+Barriera%3BMakola%2C+Mbulelo&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2008-05-01&rft.volume=51&rft.issue=5&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130701779197 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hepatitis E virus; Ergonomics; musculoskeletal system; Vibration; back pain; Reviews; Bibliographies; Materials handling; Gender; climatic conditions; posture; Historical account; Age DO - http://dx.doi.org/10.1080/00140130701779197 ER - TY - JOUR T1 - Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990-2006 AN - 19542045; 8554524 AB - Generally, live-virus vaccines are contraindicated for pregnant women because of the theoretical risk of transmission of the vaccine virus to the fetus. Advisory groups recommend avoiding pregnancy in the immediate period after administration of such contraindicated vaccines (CVs) and stress benefit-to-risk evaluation for live or inactivated vaccines regarding pregnancy. Given the limited available data and theoretical risks associated particularly with live-virus vaccines, inadvertent immunization with CVs may lead to elective termination of pregnancy (ETP), despite advisory group statements that "vaccination is not ordinarily an indication to terminate the pregnancy." The Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance system managed by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC), accepts reports of adverse events after vaccination. The objectives of this review were to describe reports of ETP in VAERS and characterize the circumstances of inadvertent administration of vaccines to pregnant women among ETP reports. We reviewed VAERS reports of ETP submitted from 1990 to 2006. Reports of ETP for reasons other than vaccination during or shortly before pregnancy, such as fetal abnormalities or deaths, were excluded. Of 80 ETP reports, 62 (78%) originated from the US; 79 (99%) were reported by manufacturers. Median age of vaccinees was 26 years (range: 13-43 years; 67 reports). Seventy-three vaccinees (91%) received a single vaccine; 65 (81%) received at least one live-virus vaccine. In 48 (60%) ETP reports, vaccinees were unaware of pregnancy at time of immunization. In 15 (19%) reports, vaccinees became pregnant within 3 months of vaccination; in 13 (16%) reports, vaccinees might have been pregnant before vaccination; in 4 (5%) reports, information was missing. All 80 reports of ETP involved vaccines for which possible effects on fetal development are unknown. However, no cases of vaccine-associated congenital rubella or varicella syndromes have been reported in the medical literature. Also, these syndromes have not been reported to varicella or rubella vaccine pregnancy registries. VAERS has the limitations of passive surveillance systems. Under-reporting of ETP in VAERS could be substantial. More attention may be needed to assess the likelihood of pregnancy when administering vaccines to women with child-bearing potential, and to inform women who learn they are pregnant shortly after being immunized of current information on risks. Quantifying the frequency of ETP related to CVs and the risk (if any) to the fetus of such vaccines can help to inform policy, practice, and individual decision making. Good quality information may be obtained from controlled observational studies. JF - Vaccine AU - Chang, Soju AU - Ball, Robert AU - Braun, MMiles AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM-222, Rockville, MD 20852 United States, soju.chang@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2428 EP - 2432 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 19 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Vaccine KW - Elective termination of pregnancy KW - VAERS KW - Mortality KW - vaccines KW - Age KW - Data processing KW - Disease control KW - Stress KW - disease control KW - Rubella KW - Fetuses KW - Pregnancy KW - immunization KW - Decision making KW - Congenital rubella KW - Reviews KW - prevention KW - FDA KW - Vaccines KW - Drugs KW - Varicella KW - X 24310:Pharmaceuticals KW - F 06905:Vaccines KW - V 22400:Human Diseases KW - H 4000:Food and Drugs KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19542045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Elective+termination+of+pregnancy+after+vaccination+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%3A+1990-2006&rft.au=Chang%2C+Soju%3BBall%2C+Robert%3BBraun%2C+MMiles&rft.aulast=Chang&rft.aufirst=Soju&rft.date=2008-05-01&rft.volume=26&rft.issue=19&rft.spage=2428&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.02.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Decision making; Age; Data processing; Congenital rubella; Reviews; Disease control; Stress; Vaccines; Rubella; Fetuses; Varicella; Pregnancy; immunization; Mortality; vaccines; FDA; prevention; disease control; Drugs DO - http://dx.doi.org/10.1016/j.vaccine.2008.02.052 ER - TY - JOUR T1 - Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat AN - 19531412; 8204082 AB - The Critical Path Institute recently established the Predictive Safety Testing Consortium, a collaboration between several companies and the U.S. Food and Drug Administration, aimed at evaluating and qualifying biomarkers for a variety of toxicological endpoints. The Carcinogenicity Working Group of the Predictive Safety Testing Consortium has concentrated on sharing data to test the predictivity of two published hepatic gene expression signatures, including the signature by Fielden et al. (2007, TOXICOL: Sci. 99, 90-100) for predicting nongenotoxic hepatocarcinogens, and the signature by Nie et al. (2006, Mol. Carcinog. 45, 914-933) for predicting nongenotoxic carcinogens. Although not a rigorous prospective validation exercise, the consortium approach created an opportunity to perform a meta-analysis to evaluate microarray data from short-term rat studies on over 150 compounds. Despite significant differences in study designs and microarray platforms between laboratories, the signatures proved to be relatively robust and more accurate than expected by chance. The accuracy of the Fielden et al. signature was between 63 and 69%, whereas the accuracy of the Nie et al. signature was between 55 and 64%. As expected, the predictivity was reduced relative to internal validation estimates reported under identical test conditions. Although the signatures were not deemed suitable for use in regulatory decision making, they were deemed worthwhile in the early assessment of drugs to aid decision making in drug development. These results have prompted additional efforts to rederive and evaluate a QPCR-based signature using these samples. When combined with a standardized test procedure and prospective interlaboratory validation, the accuracy and potential utility in preclinical applications can be ascertained. JF - Toxicological Sciences AU - Fielden, Mark R AU - Nie, Alex AU - McMillian, Michael AU - Elangbam, Chandi S AU - Trela, Bruce A AU - Yang, Yi AU - Dunn, Robert TII AU - Dragan, Yvonne AU - Fransson-Stehen, Ronny AU - Bogdanffy, Matthew AU - Adams, Stephen P AU - Foster, William R AU - Chen, Shen-Jue AU - Rossi, Phil AU - Kasper, Peter AU - Jacobson-Kram, David AU - Tatsuoka, Kay S AU - Wier, Patrick J AU - Gollub, Jeremy AU - Halbert, Donald N AU - Roter, Alan AU - Young, Jamie K AU - Sina, Joseph F AU - Marlowe, Jennifer AU - Martus, Hans-Joerg AU - Aubrecht, Jiri AU - Olaharski, Andrew J AU - Roome, Nigel AU - Nioi, Paul AU - Pardo, Ingrid AU - Snyder, Ron AU - Perry, Richard AU - Lord, Peter AU - Mattes, William AU - Car, Bruce D AD - Roche Palo Alto, Palo Alto, California. Johnson & Johnson Pharmaceutical Research & Development, Raritan, New Jersey. GlaxoSmithKline, Research Triangle Park, North Carolina. Abbott Laboratories, Abbott Park, Illinois. Amgen, Thousand Oaks, California. AstraZeneca, Boston, Massachusetts. AstraZeneca, Soedertaelje, Sweden. Boehringer-Ingelheim, Ridgefield, Connecticut. Bristol-Myers Squibb, Princeton, New Jersey. Bristol-Myers Squibb, Wallingford, Connecticut. Critical Path Institute, Tucson, Arizona. Federal Institute for Drugs and Medical Devices, Bonn, Germany. Food and Drug Administration, Washington, DC. Iconix Biosciences, Mountain View, California. Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana. Merck Research Laboratories, West Point, Pennsylvania. Novartis Pharma AG, Basel, Switzerland. Pfizer, Groton, Connecticut. Sanofi-Aventis, Porcheville, France. Schering-Plough Research Institute, Summit, New Jersey. Wyeth Research, Chazy, New York Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 28 EP - 34 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Data processing KW - Drug development KW - Carcinogens KW - Drug screening KW - biomarkers KW - Physical training KW - Gene expression KW - Decision making KW - Carcinogenicity KW - Reviews KW - Liver KW - genomics KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Interlaboratory+Evaluation+of+Genomic+Signatures+for+Predicting+Carcinogenicity+in+the+Rat&rft.au=Fielden%2C+Mark+R%3BNie%2C+Alex%3BMcMillian%2C+Michael%3BElangbam%2C+Chandi+S%3BTrela%2C+Bruce+A%3BYang%2C+Yi%3BDunn%2C+Robert+TII%3BDragan%2C+Yvonne%3BFransson-Stehen%2C+Ronny%3BBogdanffy%2C+Matthew%3BAdams%2C+Stephen+P%3BFoster%2C+William+R%3BChen%2C+Shen-Jue%3BRossi%2C+Phil%3BKasper%2C+Peter%3BJacobson-Kram%2C+David%3BTatsuoka%2C+Kay+S%3BWier%2C+Patrick+J%3BGollub%2C+Jeremy%3BHalbert%2C+Donald+N%3BRoter%2C+Alan%3BYoung%2C+Jamie+K%3BSina%2C+Joseph+F%3BMarlowe%2C+Jennifer%3BMartus%2C+Hans-Joerg%3BAubrecht%2C+Jiri%3BOlaharski%2C+Andrew+J%3BRoome%2C+Nigel%3BNioi%2C+Paul%3BPardo%2C+Ingrid%3BSnyder%2C+Ron%3BPerry%2C+Richard%3BLord%2C+Peter%3BMattes%2C+William%3BCar%2C+Bruce+D&rft.aulast=Fielden&rft.aufirst=Mark&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Decision making; Data processing; Carcinogenicity; Reviews; Liver; Drug development; Carcinogens; genomics; Drug screening; biomarkers; Physical training ER - TY - JOUR T1 - Reliable Comfort and Meaningfulness: Palliative Care Beyond Cancer AN - 57247709; 200819895 AB - To live well in the time left to them, patients with fatal chronic conditions need confidence that their healthcare system ensures excellent medical diagnosis and treatment, prevention of overwhelming symptoms, continuity and comprehensiveness of care, advance care planning, patient centred decisions, ands support for carers. Hospices and palliative care have improved these dimensions of quality for people dying from cancer. Applying those insights to other fatal chronic conditions could greatly improve the last part of life, although the endeavour entails substantial challenges. End of life care for elderly people will have to last for a long time: being disabled enough to need daily help now continues for an average of more than two years before death. Patients with non-malignant, long term illness are older and frailer than patients with cancer (as are their carers). Transfers between hospitals, nursing homes, and home care often engender delirium, depression, falls, treatment errors, and pressure ulcers, in addition to the common hospice problems of pain and loss. Entities that are often unfamiliar to hospices-such as social insurance programmes for poor people, long term care facilities, and disability transportation-will need to be partners in care. References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Lynn, Joanne AD - Office Clinical Standards & Quality, Centers for Medicare & Medicaid Services, Baltimore, MD, US Joanne.Lynn@cms.hhs.gov Y1 - 2008/04/26/ PY - 2008 DA - 2008 Apr 26 SP - 958 EP - 959 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7650 SN - 0959-535X, 0959-535X KW - Elderly people KW - Palliative care KW - Patients KW - Terminally ill people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57247709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Reliable+Comfort+and+Meaningfulness%3A+Palliative+Care+Beyond+Cancer&rft.au=Lynn%2C+Joanne&rft.aulast=Lynn&rft.aufirst=Joanne&rft.date=2008-04-26&rft.volume=336&rft.issue=7650&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39535.656319.94 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Terminally ill people; Patients; Elderly people; Palliative care DO - http://dx.doi.org/10.1136/bmj.39535.656319.94 ER - TY - CPAPER T1 - Relationship of Hepatitis C Virus to Hepatocellular Carcinoma in Dialysis Patients. T2 - 43rd Annual Meeting of the European Association for the Study of the Liver AN - 40845819; 4818906 JF - 43rd Annual Meeting of the European Association for the Study of the Liver AU - Henderson, W A AU - Gill, J M AU - Kim, K H AU - Skanderson, M AU - Butt, A A Y1 - 2008/04/23/ PY - 2008 DA - 2008 Apr 23 KW - Hepatitis KW - Dialysis KW - Hepatocellular carcinoma KW - Tumors KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Relationship+of+Hepatitis+C+Virus+to+Hepatocellular+Carcinoma+in+Dialysis+Patients.&rft.au=Henderson%2C+W+A%3BGill%2C+J+M%3BKim%2C+K+H%3BSkanderson%2C+M%3BButt%2C+A+A&rft.aulast=Henderson&rft.aufirst=W&rft.date=2008-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.easl.ch/liver-meeting/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry. AN - 69194474; 18412959 AB - The purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects. Eighteen women from four dry cleaning facilities in southwestern Ohio were monitored in a pilot study of workers with PCE exposure. Personal breathing zone samples were collected from each employee on two consecutive work days. Biological monitoring included a single measurement of PCE in blood and multiple measurements of pre- and post-shift PCE in exhaled breath and trichloroacetic acid (TCA) in urine. Post-shift PCE in exhaled breath gradually increased throughout the work week. Statistically significant correlations were observed among the exposure indices. Decreases in PCE in exhaled breath and TCA in urine were observed after two days without exposure to PCE. A mixed-effects model identified statistically significant associations between PCE in exhaled breath and airborne PCE time weighted average (TWA) after adjusting for a random participant effect and fixed effects of time and body mass index. Although comprehensive, our sampling strategy was challenging to implement due to fluctuating work schedules and the number (pre- and post-shift on three consecutive days) and multiplicity (air, blood, exhaled breath, and urine) of samples collected. PCE in blood is the preferred biological index to monitor exposures, but may make recruitment difficult. PCE TWA sampling is an appropriate surrogate, although more field intensive. Repeated measures of exposure and mixed-effects modeling may be required for future studies due to high within-subject variability. Workers should be monitored over a long enough period of time to allow the use of a lag term. JF - Environmental health : a global access science source AU - McKernan, Lauralynn T AU - Ruder, Avima M AU - Petersen, Martin R AU - Hein, Misty J AU - Forrester, Christy L AU - Sanderson, Wayne T AU - Ashley, David L AU - Butler, Mary A AD - Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA. LTaylor@cdc.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 12 VL - 7 KW - Solvents KW - 0 KW - Tetrachloroethylene KW - TJ904HH8SN KW - Index Medicus KW - Regression Analysis KW - Solvents -- analysis KW - Humans KW - Adult KW - Aged KW - Pilot Projects KW - Middle Aged KW - Body Mass Index KW - Female KW - Environmental Monitoring -- methods KW - Breath Tests KW - Tetrachloroethylene -- urine KW - Laundering KW - Occupational Exposure -- analysis KW - Tetrachloroethylene -- blood KW - Tetrachloroethylene -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69194474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Biological+exposure+assessment+to+tetrachloroethylene+for+workers+in+the+dry+cleaning+industry.&rft.au=McKernan%2C+Lauralynn+T%3BRuder%2C+Avima+M%3BPetersen%2C+Martin+R%3BHein%2C+Misty+J%3BForrester%2C+Christy+L%3BSanderson%2C+Wayne+T%3BAshley%2C+David+L%3BButler%2C+Mary+A&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-04-15&rft.volume=7&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-7-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-03 N1 - Date created - 2008-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Occup Hyg. 2001 Jan;45(1):71-81 [11137701] Int Arch Occup Environ Health. 2000 May;73(4):221-7 [10877027] Appl Occup Environ Hyg. 2002 May;17(5):352-9 [12018399] Mutat Res. 2003 Aug 5;539(1-2):9-18 [12948810] J Occup Environ Med. 2003 Nov;45(11):1152-7 [14610396] Environ Health Perspect. 1977 Dec;21:239-45 [612449] Int Arch Occup Environ Health. 1983;52(1):69-77 [6874093] Scand J Work Environ Health. 1983 Jun;9(3):273-81 [6612269] Am Ind Hyg Assoc J. 1983 Aug;44(8):600-5 [6624647] Br J Ind Med. 1986 Dec;43(12):814-24 [3801333] Arch Environ Health. 1988 Jul-Aug;43(4):292-8 [3415356] Am Ind Hyg Assoc J. 1990 Oct;51(10):566-74 [2251984] Arch Environ Health. 1991 May-Jun;46(3):174-8 [2039273] Anal Chem. 1992 May 1;64(9):1021-9 [1590585] Environ Health Perspect. 1995 Apr;103 Suppl 3:49-53 [7635112] IARC Monogr Eval Carcinog Risks Hum. 1995;63:159-221 [9097093] Am J Clin Nutr. 1998 May;67(5):934-9 [9583852] J Occup Environ Med. 1999 Jan;41(1):11-6 [9924715] J Air Waste Manag Assoc. 2001 Dec;51(12):1671-5 [15666472] JAMA. 2005 Apr 20;293(15):1861-7 [15840860] Environ Sci Technol. 2005 Oct 1;39(19):7741-8 [16245853] J Occup Environ Hyg. 2006 Nov;3(11):606-19 [17086665] J Toxicol Environ Health A. 2007 Apr 1;70(7):627-37 [17365617] Ann Occup Hyg. 2000 Jan;44(1):43-56 [10689758] Environ Health Perspect. 2000 Jun;108(6):569-73 [10856033] Am J Ind Med. 2001 Feb;39(2):121-32 [11170155] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-069X-7-12 ER - TY - JOUR T1 - Preventing household transmission of Shiga toxin-producing Escherichia coli O157 infection: promptly separating siblings might be the key. AN - 69156237; 18444854 AB - Preventing household transmission of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection is important because of the ease of interpersonal transmission and the potential disease severity. We conducted a retrospective cohort study of households associated with an outbreak of STEC O157 infection in South Wales, United Kingdom, in autumn 2005. We investigated whether characteristics of the primary case patient or the household were predictors for secondary household transmission of STEC O157 infection. Furthermore, we estimated the proportion of cases that might be prevented by isolation (e.g., hospitalization) of the primary case patient immediately after the microbiological diagnosis and the number of patients with STEC O157 who would need to be isolated to prevent 1 case of hemolytic uremic syndrome. Based on dates of symptom onset, case patients in households were classified as having primary, coprimary, or secondary infection. Secondary cases were considered to be preventable if the secondary case patient's symptoms started >1 incubation period (4 days) after the date of microbiological diagnosis of the primary case. Eighty-nine (91%) of 98 eligible households were enrolled. Among 20 households (22%), 25 secondary cases were ascertained. Thirteen secondary cases (56%) occurred in siblings of the primary case patients; hemolytic uremic syndrome developed in 4 of these siblings. Presence of a sibling (risk ratio, 3.8; 95% confidence interval, 0.99-14.6) and young age (<5 years) of the primary case patient (risk ratio, 2.03; 95% confidence interval, 0.99-41.6) were independent predictors for households in which secondary cases occurred. Of the 15 secondary cases for which complete information was available, 7 (46%) might have been prevented. When restricting isolation to primary case patients who were aged <10 years and who had a sibling, we estimated the number of patients who would need to be isolated to prevent 1 case of hemolytic uremic syndrome to be 47 patients (95% confidence interval, 16-78 patients). Promptly separating pediatric patients with STEC O157 infection from their young siblings should be considered. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Werber, Dirk AU - Mason, Brendan W AU - Evans, Meirion R AU - Salmon, Roland L AD - Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, United Kingdom. werberd@rki.de Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 1189 EP - 1196 VL - 46 IS - 8 KW - Index Medicus KW - Communicable Disease Control -- methods KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Child KW - Wales KW - Patient Isolation KW - Child, Preschool KW - Shiga-Toxigenic Escherichia coli -- isolation & purification KW - Escherichia coli Infections -- transmission KW - Escherichia coli O157 -- isolation & purification KW - Siblings KW - Escherichia coli Infections -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69156237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Preventing+household+transmission+of+Shiga+toxin-producing+Escherichia+coli+O157+infection%3A+promptly+separating+siblings+might+be+the+key.&rft.au=Werber%2C+Dirk%3BMason%2C+Brendan+W%3BEvans%2C+Meirion+R%3BSalmon%2C+Roland+L&rft.aulast=Werber&rft.aufirst=Dirk&rft.date=2008-04-15&rft.volume=46&rft.issue=8&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F587670 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 2008 Apr 15;46(8):1197-9 [18444855] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/587670 ER - TY - JOUR T1 - Occupational exposure to pesticides and risk of adult brain tumors. AN - 69110886; 18299277 AB - The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations. JF - American journal of epidemiology AU - Samanic, Claudine M AU - De Roos, Anneclaire J AU - Stewart, Patricia A AU - Rajaraman, Preetha AU - Waters, Martha A AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. samanicc@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 976 EP - 985 VL - 167 IS - 8 KW - Pesticides KW - 0 KW - Index Medicus KW - Meningeal Neoplasms -- epidemiology KW - Meningioma -- epidemiology KW - Humans KW - Aged KW - Glioma -- epidemiology KW - Risk Assessment KW - Meningeal Neoplasms -- etiology KW - Meningioma -- etiology KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Glioma -- etiology KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Brain Neoplasms -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Pesticides -- toxicity KW - Brain Neoplasms -- etiology KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69110886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Occupational+exposure+to+pesticides+and+risk+of+adult+brain+tumors.&rft.au=Samanic%2C+Claudine+M%3BDe+Roos%2C+Anneclaire+J%3BStewart%2C+Patricia+A%3BRajaraman%2C+Preetha%3BWaters%2C+Martha+A%3BInskip%2C+Peter+D&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2008-04-15&rft.volume=167&rft.issue=8&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwm401 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Jan 11;344(2):79-86 [11150357] Int J Cancer. 1999 Jul 19;82(2):155-60 [10389745] Int J Cancer. 2002 May 10;99(2):252-9 [11979441] Am J Ind Med. 2002 Sep;42(3):214-27 [12210690] Cancer Causes Control. 2003 Mar;14(2):139-50 [12749719] J Neurosurg. 2003 Nov;99(5):848-53 [14609164] Int J Cancer. 2005 Jan 1;113(1):116-25 [15386358] Bull World Health Organ. 1962;26:75-91 [13888659] Int J Cancer. 2005 May 1;114(5):797-805 [15609304] Environ Health Perspect. 2005 May;113(5):546-51 [15866761] Occup Environ Med. 2005 Nov;62(11):786-92 [16234405] Int J Cancer. 2006 Mar 1;118(5):1321-4 [16152609] Occup Environ Med. 2006 Apr;63(4):267-72 [16556747] Int J Cancer. 2006 Sep 1;119(5):1152-7 [16570277] Am J Epidemiol. 2006 Oct 1;164(7):629-36 [16835295] J Agric Saf Health. 2006 Nov;12(4):255-74 [17131948] Occup Environ Med. 2007 Aug;64(8):509-14 [17537748] Cancer. 2007 Aug 1;110(3):471-6 [17580362] Am J Ind Med. 2004 May;45(5):395-407 [15095422] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1583-8 [15466973] J Occup Med. 1979 Nov;21(11):745-8 [556268] Br J Ind Med. 1984 Feb;41(1):15-24 [6318800] Br J Cancer. 1985 Aug;52(2):259-70 [4027168] J Occup Med. 1986 Jul;28(7):497-501 [3734918] Scand J Work Environ Health. 1986 Oct;12(5):448-54 [3787216] Br J Ind Med. 1988 Feb;45(2):98-105 [3342201] J Occup Med. 1988 May;30(5):429-32 [3373347] Am J Epidemiol. 1988 Oct;128(4):778-85 [3421243] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Arch Environ Health. 1991 Mar-Apr;46(2):110-6 [2006895] Lancet. 1991 Oct 26;338(8774):1027-32 [1681353] Cancer. 1992 May 15;69(10):2541-7 [1568177] Br J Ind Med. 1992 Apr;49(4):220-5 [1571291] Scand J Work Environ Health. 1992 Jun;18(3):201-4 [1615295] Neuroepidemiology. 1992;11(4-6):267-76 [1337947] Int J Epidemiol. 1993 Aug;22(4):579-83 [8225728] Cancer Causes Control. 1993 Nov;4(6):529-38 [8280830] J Occup Med. 1993 Dec;35(12):1208-12 [8113924] Epidemiol Rev. 1995;17(2):382-414 [8654518] Int J Epidemiol. 1996 Aug;25(4):744-52 [8921451] Int J Cancer. 1997 Jul 29;72(3):389-93 [9247278] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Int J Cancer. 2002 Apr 1;98(4):609-15 [11920623] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwm401 ER - TY - JOUR T1 - Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. AN - 69109009; 18413775 AB - Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P(trend) = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P(trend) = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development. JF - Cancer research AU - Purdue, Mark P AU - Graubard, Barry I AU - Chanock, Stephen J AU - Rubertone, Mark V AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. purduem@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 3043 EP - 3048 VL - 68 IS - 8 KW - Inhibins KW - 57285-09-3 KW - Index Medicus KW - Genotype KW - Animals KW - Risk Factors KW - Military Personnel KW - Humans KW - Case-Control Studies KW - Disease Models, Animal KW - Mice KW - United States -- epidemiology KW - Male KW - Inhibins -- genetics KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Neoplasms, Germ Cell and Embryonal -- genetics KW - Testicular Neoplasms -- genetics KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69109009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genetic+variation+in+the+inhibin+pathway+and+risk+of+testicular+germ+cell+tumors.&rft.au=Purdue%2C+Mark+P%3BGraubard%2C+Barry+I%3BChanock%2C+Stephen+J%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2008-04-15&rft.volume=68&rft.issue=8&rft.spage=3043&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-5852 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Reprod. 2004 Aug;19(8):1760-4 [15205401] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Mol Cell Endocrinol. 2004 Oct 15;225(1-2):73-6 [15451570] J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):651-3 [4723959] Acta Genet Med Gemellol (Roma). 1981;30(3):189-202 [6805197] Acta Genet Med Gemellol (Roma). 1984;33(1):131-9 [6429992] Cancer. 1989 Aug 15;64(4):956-61 [2545331] Br J Urol. 1990 Sep;66(3):315-7 [2119845] Nature. 1992 Nov 26;360(6402):313-9 [1448148] Eur Urol. 1993;23(1):54-9; discussion 60-1 [8477778] BMJ. 1994 May 28;308(6941):1393-9 [7912596] Cancer Causes Control. 1995 Nov;6(6):519-24 [8580300] Nature. 1996 Dec 5;384(6608):470-4 [8945475] Cancer. 1997 Sep 1;80(5):929-35 [9307193] Br J Cancer. 1997;76(9):1191-8 [9365168] Lancet. 1997 Dec 13;350(9093):1723-8 [9413462] J Clin Endocrinol Metab. 1998 Mar;83(3):969-75 [9506758] Mol Endocrinol. 1999 Jun;13(6):851-65 [10379885] Genet Epidemiol. 2005 Apr;28(3):261-72 [15637718] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nat Genet. 2005 Dec;37(12):1320-2 [16258542] Ann N Y Acad Sci. 2005 Dec;1061:173-82 [16467266] Hum Genet. 2006 Aug;120(1):1-21 [16645853] Fertil Steril. 2007 Jan;87(1):210-2 [17084394] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):77-83 [17220333] Am J Epidemiol. 2007 Feb 15;165(4):355-63 [17110638] Dev Biol. 2000 Apr 15;220(2):225-37 [10753512] Nat Med. 2000 Jun;6(6):637-41 [10835679] Hum Reprod. 2000 Dec;15(12):2644-9 [11098038] Eur J Endocrinol. 2001 Dec;145(6):779-84 [11720904] Cancer Invest. 2001;19(8):842-53 [11768038] Mol Endocrinol. 2002 Feb;16(2):213-20 [11818495] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Hum Reprod. 2002 Jul;17(7):1741-5 [12093833] Am J Public Health. 2002 Dec;92(12):1900-4 [12453804] Semin Reprod Med. 2004 Aug;22(3):177-85 [15319820] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-5852 ER - TY - JOUR T1 - Let Patients Control the Purse Strings AN - 57256990; 200818733 AB - As the burden of disease shifts from acute to chronic care, governments are having to reshape health services. The UK health white paper, Our Health, Our Care, Our Say, published in January 2006, outlines four goals: greater prevention and early intervention, more choice and a louder voice for patients, more support for people with long term needs, and tackling inequalities. Other countries in the Organisation for Economic Cooperation and Development have stated similar objectives. If governments are serious about these aims, they would do well to learn from recent innovation in social care. In the United Kingdom, the Netherlands, the United States, and Germany, the delivery of social care services is being transformed through the introduction of individualised funding mechanisms, such as direct payments and individual budgets. These mechanisms allow services to be more accurately tailored to individual needs and could particularly benefit patients needing long term health care. Tables, Figures, References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Alakeson, Vidhya AD - Office Assistant Secretary for Planning & Evaluation, Department Health & Human Services, Washington, DC US vidhya.alakeson@hhs.gov Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 SP - 807 EP - 809 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7648 SN - 0959-535X, 0959-535X KW - Health care KW - Patents KW - UK KW - Budgets KW - National health services KW - Control KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57256990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Let+Patients+Control+the+Purse+Strings&rft.au=Alakeson%2C+Vidhya&rft.aulast=Alakeson&rft.aufirst=Vidhya&rft.date=2008-04-12&rft.volume=336&rft.issue=7648&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39524.400498.AD LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - National health services; Health care; Budgets; Control; Patents; UK DO - http://dx.doi.org/10.1136/bmj.39524.400498.AD ER - TY - CPAPER T1 - Increased Distributional Variance of Mitochondrial DNA Content Associated with Prostate Cancer Development. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873452; 4824369 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Furusawa, Jun AU - Mizumachi, Takatsugu AU - Muskhelishvili, Levan AU - Naito, Akihiro AU - Fan, Chun-Yang AU - Siegel, Eric R AU - Kadlubar, Fred F AU - Kumar, Udaya AU - Higuchi, Masahiro Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Mitochondrial DNA KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Increased+Distributional+Variance+of+Mitochondrial+DNA+Content+Associated+with+Prostate+Cancer+Development.&rft.au=Furusawa%2C+Jun%3BMizumachi%2C+Takatsugu%3BMuskhelishvili%2C+Levan%3BNaito%2C+Akihiro%3BFan%2C+Chun-Yang%3BSiegel%2C+Eric+R%3BKadlubar%2C+Fred+F%3BKumar%2C+Udaya%3BHiguchi%2C+Masahiro&rft.aulast=Furusawa&rft.aufirst=Jun&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D Np63a Alters Keratinocyte Growth Regulation via the Activation of the NF-a B Subunit c-Rel. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873047; 4824500 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - King, Kathryn E AU - Ponnamperuma, Roshini M AU - Allen, Clint AU - Chen, Zhong AU - Van Waes, Carter AU - Weinberg, Wendy C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Keratinocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=D+Np63a+Alters+Keratinocyte+Growth+Regulation+via+the+Activation+of+the+NF-a+B+Subunit+c-Rel.&rft.au=King%2C+Kathryn+E%3BPonnamperuma%2C+Roshini+M%3BAllen%2C+Clint%3BChen%2C+Zhong%3BVan+Waes%2C+Carter%3BWeinberg%2C+Wendy+C&rft.aulast=King&rft.aufirst=Kathryn&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Non-Mutational Mechanisms in Cancer Cell Drug Resistance. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866783; 4822761 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Chekhun, Vasyl' F AU - Filkowski, Jody AU - Meservy, James AU - Ilnytskyy, Yaroslav AU - Mykytenko, Dmytro AU - Tryndyak, Volodymyr AU - Pogribny, Igor P AU - Kovalchuk, Olga Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Drug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Role+of+Non-Mutational+Mechanisms+in+Cancer+Cell+Drug+Resistance.&rft.au=Chekhun%2C+Vasyl%27+F%3BFilkowski%2C+Jody%3BMeservy%2C+James%3BIlnytskyy%2C+Yaroslav%3BMykytenko%2C+Dmytro%3BTryndyak%2C+Volodymyr%3BPogribny%2C+Igor+P%3BKovalchuk%2C+Olga&rft.aulast=Chekhun&rft.aufirst=Vasyl%27&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidant-Induced Apoptosis is Mediated by Oxidation of the Actin-Regulatory Protein Cofilin. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866595; 4823023 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Zdanov, Stephanie AU - Klamt, Fabio AU - Levine, Rodney L AU - Shacter, Emily Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Oxidation KW - Cofilin KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Oxidant-Induced+Apoptosis+is+Mediated+by+Oxidation+of+the+Actin-Regulatory+Protein+Cofilin.&rft.au=Zdanov%2C+Stephanie%3BKlamt%2C+Fabio%3BLevine%2C+Rodney+L%3BShacter%2C+Emily&rft.aulast=Zdanov&rft.aufirst=Stephanie&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Upregulation of Interleukin 13 Receptor (IL-13R) by Adrenomedullin (AM) in Human Prostate Cancer Model T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864329; 4820789 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Joshi, Bharat H AU - Leland, Pamela AU - Calvo, Alfonso AU - Montuenga, Luis AU - Green, Jeffrey AU - Puri, Raj K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Adrenomedullin KW - Interleukin 13 receptors KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Upregulation+of+Interleukin+13+Receptor+%28IL-13R%29+by+Adrenomedullin+%28AM%29+in+Human+Prostate+Cancer+Model&rft.au=Joshi%2C+Bharat+H%3BLeland%2C+Pamela%3BCalvo%2C+Alfonso%3BMontuenga%2C+Luis%3BGreen%2C+Jeffrey%3BPuri%2C+Raj+K&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNA miR-16 Linked to the Development and Progression of B Cell Malignancies in the NZB de novo Murine Model of CLL. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859882; 4822941 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Salerno, Erica AU - Scaglione, Brian AU - Coffman, Frederick AU - Fernandes, Helen AU - Marti, Gerald E AU - Baskar, Sivasubramanian AU - Rader, Christoph AU - Raveche, Elizabeth Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphocytes B KW - Animal models KW - Malignancy KW - MiRNA KW - Chronic lymphatic leukemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=MicroRNA+miR-16+Linked+to+the+Development+and+Progression+of+B+Cell+Malignancies+in+the+NZB+de+novo+Murine+Model+of+CLL.&rft.au=Salerno%2C+Erica%3BScaglione%2C+Brian%3BCoffman%2C+Frederick%3BFernandes%2C+Helen%3BMarti%2C+Gerald+E%3BBaskar%2C+Sivasubramanian%3BRader%2C+Christoph%3BRaveche%2C+Elizabeth&rft.aulast=Salerno&rft.aufirst=Erica&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SNP rs380390 of Complement Factor H Gene is Associated with the Risk of Lung Cancer and Interacts with ERCC6 SNP rs3793784. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858132; 4822641 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Zhang, Xuemei AU - Guo, Yongli AU - Tuo, Jingsheng AU - Green, Bridgett AU - Wise, Carolyn AU - Kadlubar, Susan AU - Kadlubar, Fred F AU - Lin, Dongxin AU - Ning, Baitang Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Single-nucleotide polymorphism KW - Complement factor H KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+SNP+rs380390+of+Complement+Factor+H+Gene+is+Associated+with+the+Risk+of+Lung+Cancer+and+Interacts+with+ERCC6+SNP+rs3793784.&rft.au=Zhang%2C+Xuemei%3BGuo%2C+Yongli%3BTuo%2C+Jingsheng%3BGreen%2C+Bridgett%3BWise%2C+Carolyn%3BKadlubar%2C+Susan%3BKadlubar%2C+Fred+F%3BLin%2C+Dongxin%3BNing%2C+Baitang&rft.aulast=Zhang&rft.aufirst=Xuemei&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Mechanisms of Differential Apoptosis between Human Melanoma Cell Lines UACC903 and UACC903(+6) Revealed by Mitochondria-focused cDNA Microarrays T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856985; 4821894 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Bi-Dar AU - Zhang, Qiuyang AU - Nguyen, AnhThu AU - Wu, Jun AU - He, Ping AU - St Laurent, Georges AU - Rennert, Owen AU - Su, Yan A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - DNA microarrays KW - Mitochondria KW - Apoptosis KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Molecular+Mechanisms+of+Differential+Apoptosis+between+Human+Melanoma+Cell+Lines+UACC903+and+UACC903%28%2B6%29+Revealed+by+Mitochondria-focused+cDNA+Microarrays&rft.au=Wang%2C+Bi-Dar%3BZhang%2C+Qiuyang%3BNguyen%2C+AnhThu%3BWu%2C+Jun%3BHe%2C+Ping%3BSt+Laurent%2C+Georges%3BRennert%2C+Owen%3BSu%2C+Yan+A&rft.aulast=Wang&rft.aufirst=Bi-Dar&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BMI, NSAIDs and Multiple Disease Outcomes. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855285; 4822597 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huang, Wen-Yi AU - Weiss, Jocelyn AU - Purdue, Mark AU - Berndt, Sonja AU - Daugherty, Sarah AU - Pinsky, Paul F AU - Weissfeld, Joel L AU - Hayes, Richard B Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nonsteroidal antiinflammatory drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=BMI%2C+NSAIDs+and+Multiple+Disease+Outcomes.&rft.au=Huang%2C+Wen-Yi%3BWeiss%2C+Jocelyn%3BPurdue%2C+Mark%3BBerndt%2C+Sonja%3BDaugherty%2C+Sarah%3BPinsky%2C+Paul+F%3BWeissfeld%2C+Joel+L%3BHayes%2C+Richard+B&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different Patterns of miRNA Expression Distinguish Genotoxic and Non-genotoxic Rat Hepatocarcinogenesis T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854652; 4820264 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Tryndyak, Volodymyr AU - Muskhelishvili, Levan AU - Bagnyukova, Tetyana AU - Montgomery, Beverly AU - Beland, Frederick AU - Pogribny, Igor P Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Genotoxicity KW - MiRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Different+Patterns+of+miRNA+Expression+Distinguish+Genotoxic+and+Non-genotoxic+Rat+Hepatocarcinogenesis&rft.au=Tryndyak%2C+Volodymyr%3BMuskhelishvili%2C+Levan%3BBagnyukova%2C+Tetyana%3BMontgomery%2C+Beverly%3BBeland%2C+Frederick%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carcinogenic Potential of Tar-based Vaginal Douche Products and Cervical Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853748; 4822115 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Haverkos, Harry W AU - Boring, Daniel AU - Kruhlak, Naomi L AU - Matthews, Edwin J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cervical cancer KW - Carcinogenicity KW - Vagina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Carcinogenic+Potential+of+Tar-based+Vaginal+Douche+Products+and+Cervical+Cancer&rft.au=Haverkos%2C+Harry+W%3BBoring%2C+Daniel%3BKruhlak%2C+Naomi+L%3BMatthews%2C+Edwin+J&rft.aulast=Haverkos&rft.aufirst=Harry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumorigenicity of Acrylamide and its Metabolite Glycidamide in the Neonatal Mouse Bioassay T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852762; 4822129 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Von Tungeln, Linda S AU - Doerge, Daniel R AU - da Costa, Goncalo Gamboa AU - Marques, M Matilde AU - Beland, Frederick A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Metabolites KW - Neonates KW - Bioassays KW - Acrylamide KW - Tumorigenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumorigenicity+of+Acrylamide+and+its+Metabolite+Glycidamide+in+the+Neonatal+Mouse+Bioassay&rft.au=Von+Tungeln%2C+Linda+S%3BDoerge%2C+Daniel+R%3Bda+Costa%2C+Goncalo+Gamboa%3BMarques%2C+M+Matilde%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acrylamide Increases Levels of Nitric Oxide Synthase and Cox-2 in Normal Breast Cell In Vitro T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852402; 4821964 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook Jr., L.E. AU - Tareke, E AU - Word, B AU - Starlard-Davenport, A AU - Lyn-Cook, B D AU - Hammons, G J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nitric-oxide synthase KW - Acrylamide KW - Cyclooxygenase-2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Acrylamide+Increases+Levels+of+Nitric+Oxide+Synthase+and+Cox-2+in+Normal+Breast+Cell+In+Vitro&rft.au=Lyn-Cook+Jr.%2C+L.E.%3BTareke%2C+E%3BWord%2C+B%3BStarlard-Davenport%2C+A%3BLyn-Cook%2C+B+D%3BHammons%2C+G+J&rft.aulast=Lyn-Cook+Jr.&rft.aufirst=L.E.&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auto-oxidation and Oligomerization of Protein S on the Apoptotic Cell Surface is Required for MerTK-mediated Phagocytosis of Apoptotic Cells T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40851952; 4821865 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Uehara, Hiroshi AU - Shacter, Emily Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Apoptosis KW - Oligomerization KW - Phagocytosis KW - Cell surface KW - Protein S KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Auto-oxidation+and+Oligomerization+of+Protein+S+on+the+Apoptotic+Cell+Surface+is+Required+for+MerTK-mediated+Phagocytosis+of+Apoptotic+Cells&rft.au=Uehara%2C+Hiroshi%3BShacter%2C+Emily&rft.aulast=Uehara&rft.aufirst=Hiroshi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indole-3-carbinol (I3C) Reactives p16 in Pancreatic Cancer Cells through Hypomethylation T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40850840; 4821786 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook, Beverly D AU - Haefele, Aaron AU - Word, Beverly AU - Hammons, George Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pancreatic cancer KW - Indole-3-carbinol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40850840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Indole-3-carbinol+%28I3C%29+Reactives+p16+in+Pancreatic+Cancer+Cells+through+Hypomethylation&rft.au=Lyn-Cook%2C+Beverly+D%3BHaefele%2C+Aaron%3BWord%2C+Beverly%3BHammons%2C+George&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparative Study of Host Cell Responses to M._tuberculosis PE_PGRS Proteins T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40967921; 4869231 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Singh, P P Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Comparative studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40967921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=A+Comparative+Study+of+Host+Cell+Responses+to+M._tuberculosis+PE_PGRS+Proteins&rft.au=Singh%2C+P+P&rft.aulast=Singh&rft.aufirst=P&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating Old and New TB Vaccines: The Search for Correlates of Protection and a New Potency Assay T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40964545; 4869236 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Parra, M Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Evaluating+Old+and+New+TB+Vaccines%3A+The+Search+for+Correlates+of+Protection+and+a+New+Potency+Assay&rft.au=Parra%2C+M&rft.aulast=Parra&rft.aufirst=M&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Effectiveness of New Recombinant Modified Vaccinia Ankara Vaccines Against Tuberculosis T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40964505; 4869234 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Kolibab, K Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Turkey, Ankara KW - Vaccines KW - Tuberculosis KW - Vaccinia KW - Disease control KW - Recombinants KW - Mycobacterium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Characterization+of+the+Effectiveness+of+New+Recombinant+Modified+Vaccinia+Ankara+Vaccines+Against+Tuberculosis&rft.au=Kolibab%2C+K&rft.aulast=Kolibab&rft.aufirst=K&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-infection Vaccines, are they Safe? T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40960393; 4869193 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Morris, Sheldon Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40960393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Post-infection+Vaccines%2C+are+they+Safe%3F&rft.au=Morris%2C+Sheldon&rft.aulast=Morris&rft.aufirst=Sheldon&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quantitative determination of thallium binding to ferric hexacyanoferrate: Prussian blue. AN - 70386619; 18226478 AB - Ferric hexacyanoferrate, (Fe(4)(III)[Fe(II)(CN)(6)](3)), also known as insoluble Prussian blue (PB), is the active pharmaceutical ingredient (API) of Radiogardase which is the first approved drug product (DP) for treatment of thallium and radiocesium poisoning. The aim of this study is (1) to determine the in vitro thallium binding capacity and binding rates of insoluble PB; and (2) to evaluate the effect of physiological pH conditions, PB particle size and storage conditions on the binding to PB. Experimental pH levels from 1.0 to 7.5 were used to cover the range of pH levels that PB may encounter when traveling through the gastrointestinal (GI) tract in humans. Measurements of thallium binding were made between 1 and 24h, to cover gastric and intestinal tract residence time. PB was found to have a binding capacity of approximately 1400 mg/g at pH 7.5. When the pH decreased, the binding decreased as well. The results indicated that the hydration state of PB influences the thallium binding process. It was also found that there exits a direct correlation between the moisture loss in PB and the thallium binding rate constant. The PB with 17 mol of water had a binding rate constant of 0.52, which was reduced to 0.32 when PB was dehydrated to 2.5 mol of water. Significant differences were observed in both binding capacity and binding rate constant among PB fractions with different particle size ranges. PB fraction with particle size of 220-1000 microm had a binding rate constant of 0.43, which increased to 0.64 when the particle size was reduced to 32-90 microm. Batch-to-batch variation in thallium binding was also observed among the APIs and the DPs and this was related to particle size and hydration state. These findings can be utilized to evaluate and predict drug product quality under certain manufacturing and dry storage conditions. JF - International journal of pharmaceutics AU - Yang, Yongsheng AU - Faustino, Patrick J AU - Progar, Joseph J AU - Brownell, Charles R AU - Sadrieh, Nakissa AU - May, Joan C AU - Leutzinger, Eldon AU - Place, David A AU - Duffy, Eric P AU - Yu, Lawrence X AU - Khan, Mansoor A AU - Lyon, Robbe C AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Testing and Research, Division of Product Quality Research, Silver Spring, MD 20993, USA. Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 SP - 187 EP - 194 VL - 353 IS - 1-2 SN - 0378-5173, 0378-5173 KW - Ferrocyanides KW - 0 KW - Thallium KW - AD84R52XLF KW - ferric ferrocyanide KW - TLE294X33A KW - Index Medicus KW - Particle Size KW - Hydrogen-Ion Concentration KW - Ferrocyanides -- chemistry KW - Thallium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70386619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pharmaceutics&rft.atitle=Quantitative+determination+of+thallium+binding+to+ferric+hexacyanoferrate%3A+Prussian+blue.&rft.au=Yang%2C+Yongsheng%3BFaustino%2C+Patrick+J%3BProgar%2C+Joseph+J%3BBrownell%2C+Charles+R%3BSadrieh%2C+Nakissa%3BMay%2C+Joan+C%3BLeutzinger%2C+Eldon%3BPlace%2C+David+A%3BDuffy%2C+Eric+P%3BYu%2C+Lawrence+X%3BKhan%2C+Mansoor+A%3BLyon%2C+Robbe+C&rft.aulast=Yang&rft.aufirst=Yongsheng&rft.date=2008-04-02&rft.volume=353&rft.issue=1-2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2007.11.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-23 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijpharm.2007.11.031 ER - TY - CPAPER T1 - Impact of the 1998 Renal Guidance on Recent New Drug Application Submissions T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40913976; 4847407 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Huang, S AU - Abraham, S AU - Apparaju, S AU - Atkinson Jr, A AU - Burckart, G AU - Lee, C AU - Roy, K AU - Strong, J AU - Xiao, S AU - Wu, T. AU - Zhang, L AU - Zhang, Y AU - Lesko, L Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Drugs KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40913976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=Impact+of+the+1998+Renal+Guidance+on+Recent+New+Drug+Application+Submissions&rft.au=Huang%2C+S%3BAbraham%2C+S%3BApparaju%2C+S%3BAtkinson+Jr%2C+A%3BBurckart%2C+G%3BLee%2C+C%3BRoy%2C+K%3BStrong%2C+J%3BXiao%2C+S%3BWu%2C+T.%3BZhang%2C+L%3BZhang%2C+Y%3BLesko%2C+L&rft.aulast=Huang&rft.aufirst=S&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - QT Prolongation Potential for New Molecular Entity Drugs Approved by FDA, 2003-2006: Labeling Review T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40911715; 4847279 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Gevorkian, N AU - Sharma, P AU - Pinnow, E AU - Parekh, A Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Reviews KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=QT+Prolongation+Potential+for+New+Molecular+Entity+Drugs+Approved+by+FDA%2C+2003-2006%3A+Labeling+Review&rft.au=Gevorkian%2C+N%3BSharma%2C+P%3BPinnow%2C+E%3BParekh%2C+A&rft.aulast=Gevorkian&rft.aufirst=N&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inclusion of Subpopulations in Early Phase Clinical Trials Submitted to the FDA: A Review of NMES Approved in 2006 T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40911510; 4847412 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Pinnow, E AU - Parekh, A AU - Sharma, P AU - Gevorkian, N AU - Uhl, K Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Clinical trials KW - Reviews KW - Subpopulations KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=Inclusion+of+Subpopulations+in+Early+Phase+Clinical+Trials+Submitted+to+the+FDA%3A+A+Review+of+NMES+Approved+in+2006&rft.au=Pinnow%2C+E%3BParekh%2C+A%3BSharma%2C+P%3BGevorkian%2C+N%3BUhl%2C+K&rft.aulast=Pinnow&rft.aufirst=E&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effect of p53 genotype on gene expression profiles in murine liver AN - 19800395; 8254809 AB - The tumor suppressor protein p53 is a key regulatory element in the cell and is regarded as the ''guardian of the genome''. Much of the present knowledge of p53 function has come from studies of transgenic mice in which the p53 gene has undergone a targeted deletion. In order to provide additional insight into the impact on the cellular regulatory networks associated with the loss of this gene, microarray technology was utilized to assess gene expression in tissues from both the p53 super(-) super(/) super(-) and p53 super(+) super(/) super(-) mice. Six male mice from each genotype (p53 super(+) super(/) super(+), p53 super(+) super(/) super(-), and p53 super(-) super(/) super(-)) were humanely killed and the tissues processed for microarray analysis. The initial studies have been performed in the liver for which the Dunnett test revealed 1406 genes to be differentially expressed between p53 super(+) super(/) super(+) and p53 super(+) super(/) super(-) or between p53 super(+) super(/) super(+) and p53 super(-) super(/) super(-) at the level of p approximately equal to 0.05. Both genes with increased expression and decreased expression were identified in p53 super(+) super(/) super(-) and in p53 super(-) super(/) super(-) mice. Most notable in the gene list derived from the p53 super(+) super(/) super(-) mice was the significant reduction in p53 mRNA. In the p53 super(-) super(/) super(-) mice, not only was there reduced expression of the p53 genes on the array, but genes associated with DNA repair, apoptosis, and cell proliferation were differentially expressed, as expected. However, altered expression was noted for many genes in the Cdc42-GTPase pathways that influence cell proliferation. This may indicate that alternate pathways are brought into play in the unperturbed liver when loss or reduction in p53 levels occurs. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Morris, S M AU - Akerman, G S AU - Desai, V G AU - Tsai, Ca AU - Tolleson, W H AU - Melchior, W B AU - Lin, C J AU - Fuscoe, J C AU - Casciano, DA AU - Chen, J J AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States, suzanne.morris@fda.hhs.gov Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 SP - 54 EP - 73 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 640 IS - 1-2 SN - 1386-1964, 1386-1964 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Genomes KW - Tumor suppressor genes KW - Molecular modelling KW - Play KW - Apoptosis KW - Regulatory sequences KW - Genotypes KW - DNA repair KW - Transgenic mice KW - p53 protein KW - Mutagenesis KW - Gene expression KW - Gene deletion KW - Liver KW - Cell proliferation KW - W 30925:Genetic Engineering KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19800395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Effect+of+p53+genotype+on+gene+expression+profiles+in+murine+liver&rft.au=Morris%2C+S+M%3BAkerman%2C+G+S%3BDesai%2C+V+G%3BTsai%2C+Ca%3BTolleson%2C+W+H%3BMelchior%2C+W+B%3BLin%2C+C+J%3BFuscoe%2C+J+C%3BCasciano%2C+DA%3BChen%2C+J+J&rft.aulast=Morris&rft.aufirst=S&rft.date=2008-04-02&rft.volume=640&rft.issue=1-2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=13861964&rft_id=info:doi/10.1016%2Fj.mrfmmm.2007.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Tumor suppressor genes; Apoptosis; Play; Regulatory sequences; Genotypes; Transgenic mice; DNA repair; Mutagenesis; p53 protein; Gene expression; Gene deletion; Liver; Cell proliferation DO - http://dx.doi.org/10.1016/j.mrfmmm.2007.12.004 ER - TY - JOUR T1 - Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. AN - 71637716; 18441258 AB - Immunohistochemical studies for kidney injury molecule-1 (Kim-1), renal papillary antigen-1 (RPA-1), and renal papillary antigen-2 (RPA-2) were conducted to explore their relationship to inducible nitric oxide synthase (iNOS) and nitrotyrosine expression. Male Sprague-Dawley rats were exposed to gentamicin (100 mg/kg/day Gen, sc, for 3 days), mercury (0.25 mg Hg/kg, iv, single dose), or chromium (5 mg Cr/kg, sc, single dose) and kidney tissue was examined 24 hours or 72 hours after the last dose of the nephrotoxicant. Another group of kidneys was evaluated 24 hours after rats were administered 3 daily doses (50, 100, 150, 200, or 300 mg/kg/day) of Gen. Gen- and Cr-treated rats exhibited increased immunoreactivity of Kim-1, RPA-1, and RPA-2 largely in the S1/S2 segments and to a lesser extent in the S3 segments of the proximal tubule of the kidney, whereas Hg-treated rats showed increased immunoreactivity of Kim-1, RPA-1, and RPA-2 in the S3 segments. Up-regulation of Kim-1, RPA-1, and RPA-2 expression correlated with injured tubular epithelial cells and also correlated with immunoreactivity of iNOS and nitrotyrosine. It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants. JF - Toxicologic pathology AU - Zhang, Jun AU - Brown, Ronald P AU - Shaw, Martin AU - Vaidya, Vishal S AU - Zhou, Yuzhao AU - Espandiari, Parvaneh AU - Sadrieh, Nakissa AU - Stratmeyer, Melvin AU - Keenan, Joe AU - Kilty, Cormac G AU - Bonventre, Joseph V AU - Goering, Peter L AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. jun.zhang@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 397 EP - 409 VL - 36 IS - 3 KW - Antigens KW - 0 KW - Biomarkers KW - Cell Adhesion Molecules KW - Gentamicins KW - Havcr1protein, rat KW - Xenobiotics KW - renal tubular antigen KW - Peroxynitrous Acid KW - 14691-52-2 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Mercuric Chloride KW - 53GH7MZT1R KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, rat KW - Potassium Dichromate KW - T4423S18FM KW - Index Medicus KW - Peroxynitrous Acid -- metabolism KW - Animals KW - Dose-Response Relationship, Drug KW - Fluorescent Antibody Technique, Indirect KW - Disease Models, Animal KW - Kidney Tubules, Proximal -- pathology KW - Rats KW - Gentamicins -- toxicity KW - Rats, Sprague-Dawley KW - Potassium Dichromate -- toxicity KW - Kidney Tubules, Proximal -- metabolism KW - Apoptosis -- drug effects KW - Biomarkers -- metabolism KW - Kidney Tubules, Proximal -- drug effects KW - Up-Regulation KW - Mercuric Chloride -- toxicity KW - Immunohistochemistry KW - Male KW - Immunoenzyme Techniques KW - Kidney -- metabolism KW - Antigens -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Cell Adhesion Molecules -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - Xenobiotics -- toxicity KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71637716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Immunolocalization+of+Kim-1%2C+RPA-1%2C+and+RPA-2+in+kidney+of+gentamicin-%2C+mercury-%2C+or+chromium-treated+rats%3A+relationship+to+renal+distributions+of+iNOS+and+nitrotyrosine.&rft.au=Zhang%2C+Jun%3BBrown%2C+Ronald+P%3BShaw%2C+Martin%3BVaidya%2C+Vishal+S%3BZhou%2C+Yuzhao%3BEspandiari%2C+Parvaneh%3BSadrieh%2C+Nakissa%3BStratmeyer%2C+Melvin%3BKeenan%2C+Joe%3BKilty%2C+Cormac+G%3BBonventre%2C+Joseph+V%3BGoering%2C+Peter+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-04-01&rft.volume=36&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308315832 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Surg Pathol. 2007 Mar;31(3):371-81 [17325478] Toxicol Pathol. 2007 Feb;35(2):270-5 [17366321] Expert Opin Drug Saf. 2007 Mar;6(2):207-15 [17367267] J Pathol. 2007 Jun;212(2):209-17 [17471468] Toxicol Sci. 2007 Oct;99(2):637-48 [17636248] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] Drug Metab Rev. 1999 Nov;31(4):971-97 [10575556] Kidney Int. 2000 May;57(5):1968-72 [10792615] Mol Cell Biochem. 2001 Jun;222(1-2):149-58 [11678597] Kidney Int. 2002 Mar;61(3):855-61 [11849438] Kidney Int. 2002 Jul;62(1):237-44 [12081583] Nephron. 2002 Sep;92(1):133-41 [12187096] Diabetes. 2002 Nov;51(11):3274-82 [12401719] Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36 [12388382] Antioxid Redox Signal. 2002 Dec;4(6):915-24 [12573140] J Biol Chem. 2003 Jul 18;278(29):27256-66 [12682064] Life Sci. 2003 Oct 3;73(20):2543-56 [12967679] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765] Cancer. 1977 Apr;39(4):1362-71 [851939] Ren Physiol. 1987;10(1):54-64 [3685614] J Pharmacol Exp Ther. 1988 Mar;244(3):1081-5 [3252023] Cancer Chemother Pharmacol. 1989;25(1):1-9 [2686850] Exp Pathol. 1990;38(4):231-9 [2387365] Am J Physiol. 1994 Nov;267(5 Pt 2):F748-57 [7526707] Arch Toxicol. 1996;71(1-2):80-92 [9010589] Hypertension. 1997 Oct;30(4):948-52 [9336398] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] Toxicol Pathol. 1998 Jan-Feb;26(1):92-103 [9502391] Kidney Int. 1998 Jun;53(6):1642-6 [9607195] Ind Health. 1998 Oct;36(4):324-30 [9810145] Am J Physiol. 1999 Jun;276(6 Pt 2):F874-81 [10362776] Am J Physiol. 1999 Jul;277(1 Pt 2):F33-40 [10409295] Arch Toxicol. 1999 Jun-Jul;73(4-5):233-45 [10463389] Toxicology. 2005 Feb 14;207(2):169-77 [15596248] BMC Nephrol. 2005;6:4 [15854231] J Nephrol. 2005 Sep-Oct;18(5):548-52 [16299680] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] J Pharmacol Exp Ther. 2006 Mar;316(3):1038-46 [16306274] Toxicol Pathol. 2006;34(2):152-63 [16537294] Nat Rev Cancer. 2006 Jul;6(7):521-34 [16794635] Am J Physiol Renal Physiol. 2006 Aug;291(2):F456-64 [16467126] Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713 [17014390] Cancer Biomark. 2005;1(1):69-74 [17192033] Am J Physiol Renal Physiol. 2007 Jan;292(1):F313-20 [16896183] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Kidney Int. 2007 Mar;71(5):417-24 [17213874] Kidney Int. 2008 Mar;73(5):608-14 [18160964] Comment In: Toxicol Pathol. 2008 Oct;36(6):890; author reply 891-3 [18701423] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308315832 ER - TY - JOUR T1 - Occupational risks for idiopathic pulmonary fibrosis mortality in the United States. AN - 70796109; 18507288 AB - Metal and wood dust exposures have been identified as possible occupational risk factors for idiopathic pulmonary fibrosis (IPF). We analyzed mortality data using ICD-10 code J84.1--"Other interstitial pulmonary diseases with fibrosis," derived age-adjusted mortality rates for 1999-2003, and assessed occupational risks for 1999, by calculating proportionate mortality ratios (PMRs) and mortality odds ratios (MORs) using a matched case-control approach. We identified 84,010 IPF deaths, with an age-adjusted mortality rate of 75.7 deaths/million. Mortality rates were highest among males, whites, and those aged 85 and older. Three industry categories with potential occupational exposures recognized as risk factors for IPF were identified: "Wood buildings and mobile homes" (PMR = 4.5, 95% confidence interval (CI) 1.2-11.6 and MOR = 5.3, 95% CI 1.2-23.8), "Metal mining" (PMR = 2.4, 95% CI 1.3-4.0 and MOR = 2.2, 95% CI 1.1-4.4), and "Fabricated structural metal products" (PMR = 1.9, 95% CI 1.1-3.1 and MOR = 1.7, 95% CI 1.0-3.1). Workers in these industry categories may benefit from toxicological studies and improved surveillance for this disease. JF - International journal of occupational and environmental health AU - Pinheiro, Germania A AU - Antao, Vinicius C AU - Wood, John M AU - Wassell, James T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. germania.pinheiro@yahoo.com PY - 2008 SP - 117 EP - 123 VL - 14 IS - 2 SN - 1077-3525, 1077-3525 KW - Dust KW - 0 KW - Metals KW - Index Medicus KW - Humans KW - Wood KW - Aged KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Industry KW - Occupational Exposure KW - Pulmonary Fibrosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70796109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Occupational+risks+for+idiopathic+pulmonary+fibrosis+mortality+in+the+United+States.&rft.au=Pinheiro%2C+Germania+A%3BAntao%2C+Vinicius+C%3BWood%2C+John+M%3BWassell%2C+James+T&rft.aulast=Pinheiro&rft.aufirst=Germania&rft.date=2008-04-01&rft.volume=14&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular epidemiological analysis and microbial source tracking of Salmonella enterica serovars in a preharvest turkey production environment. AN - 70500922; 18361686 AB - Epidemiological studies were conducted to source track and delineate horizontal transmission pathways of Salmonella serovars in a turkey production environment. Salmonella enterica serovar Heidelberg (n = 111), Salmonella Senftenberg (n = 14), Salmonella Muenster (n = 10), unidentifiable "roughs" (n = 5), Salmonella Anatum (n = 3), and Salmonella Worthington (n = 2) were isolated from the birds' cecal and crop contents, litter, environmental swabs, drinkers, and feed samples. These strains (n = 145) were analyzed for their antimicrobial susceptibility profiles and the bacterial horizontal transmission pathways were tracked by XbaI-digested pulsed-field gel electrophoresis (PFGE) macrorestriction profiles. Nearly 79% of the strains were resistant to one or more antimicrobials, while 44% of the strains were resistant to two to six antimicrobials. Nearly 21% of the strains were susceptible to all of the antimicrobials tested. Twenty-seven distinct PFGE fingerprint profiles (90-95% similarity) were observed among 110 Salmonella Heidelberg strains (one strain was untypeable), and 13 of the 27 profiles (48%) elicited 100% similarity among the fingerprint patterns. The prevalence of Salmonella Heidelberg strains at weeks 2 (n = 20), 10 (n = 20), and 18 (n = 70) among the sampled pens suggested cross-colonization among pens during the 20-week production cycle. Salmonella Heidelberg strains were first isolated from the birds at week 2, and identical fingerprint profiles of this serovar were subsequently isolated from birds within the same pen; birds in other pens; and litter, air, and swab samples at weeks 10 and 18, suggesting possible horizontal transmission of this serovar across the production facility during the grow-out period. JF - Foodborne pathogens and disease AU - Nayak, Rajesh AU - Stewart-King, Tabitha AD - U.S. Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, Arkansas 72079, USA. Rajesh.Nayak@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 115 EP - 126 VL - 5 IS - 2 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Phylogeny KW - Feces -- microbiology KW - Animals KW - Humans KW - Food Contamination -- analysis KW - Serotyping KW - Drug Resistance, Multiple, Bacterial KW - DNA, Bacterial -- analysis KW - Genotype KW - Food Contamination -- prevention & control KW - Food Microbiology KW - Molecular Epidemiology KW - Electrophoresis, Gel, Pulsed-Field KW - Colony Count, Microbial KW - Microbial Sensitivity Tests KW - Environmental Microbiology KW - Salmonella enterica -- isolation & purification KW - Turkeys -- microbiology KW - Consumer Product Safety KW - Drug Resistance, Bacterial KW - Salmonella enterica -- genetics KW - Anti-Bacterial Agents -- pharmacology KW - Salmonella enterica -- classification KW - Salmonella enterica -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70500922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Molecular+epidemiological+analysis+and+microbial+source+tracking+of+Salmonella+enterica+serovars+in+a+preharvest+turkey+production+environment.&rft.au=Nayak%2C+Rajesh%3BStewart-King%2C+Tabitha&rft.aulast=Nayak&rft.aufirst=Rajesh&rft.date=2008-04-01&rft.volume=5&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2007.0029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/fpd.2007.0029 ER - TY - JOUR T1 - Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study. AN - 70493064; 18326518 AB - Pesticide exposure assessment in the Agricultural Health Study (AHS) has relied upon two exposure metrics: lifetime exposure days and intensity-weighted lifetime exposure days, the latter incorporating an intensity score computed from a questionnaire-based algorithm. We evaluated this algorithm using actual fungicide exposure measurements from AHS private orchard applicators. Captan was selected as a marker of fungicide exposure. Seventy-four applicators from North Carolina and Iowa growing apples and/or peaches were sampled on 2 days they applied captan in 2002 and 2003. Personal air, hand rinse, 10 dermal patches, a pre-application first-morning urine and a subsequent 24-h urine sample were collected from each applicator per day. Environmental samples were analyzed for captan, and urine samples were analyzed for cis-1,2,3,6-tetrahydrophthalimide (THPI). Task and personal protective equipment information needed to compute an individual's algorithm score was also collected. Differences in analyte detection frequency were tested in a repeated logistic regression model. Mixed-effects models using maximum-likelihood estimation were employed to estimate geometric mean exposures and to evaluate the measured exposure data against the algorithm. In general, captan and THPI were detected significantly more frequently in environmental and urine samples collected from applicators who used air blast sprayers as compared to those who hand sprayed. The AHS pesticide exposure intensity algorithm, while significantly or marginally predictive of thigh and forearm captan exposure, respectively, did not predict air, hand rinse or urinary THPI exposures. The algorithm's lack of fit with some exposure measures among orchard fungicide applicators may be due in part to the assignment of equal exposure weights to air blast and hand spray application methods in the current algorithm. Some modification of the algorithm is suggested by these results. JF - The Annals of occupational hygiene AU - Hines, Cynthia J AU - Deddens, James A AU - Jaycox, Larry B AU - Andrews, Ronnee N AU - Striley, Cynthia A F AU - Alavanja, Michael C R AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-14, Cincinnati, OH 45226, USA. chines@cde.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 153 EP - 166 VL - 52 IS - 3 KW - Fungicides, Industrial KW - 0 KW - Captan KW - EOL5G26Q9F KW - Index Medicus KW - Humans KW - Algorithms KW - Fruit KW - Models, Biological KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Agriculture KW - Fungicides, Industrial -- analysis KW - Fungicides, Industrial -- administration & dosage KW - Captan -- administration & dosage KW - Occupational Exposure -- analysis KW - Captan -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70493064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Captan+exposure+and+evaluation+of+a+pesticide+exposure+algorithm+among+orchard+pesticide+applicators+in+the+Agricultural+Health+Study.&rft.au=Hines%2C+Cynthia+J%3BDeddens%2C+James+A%3BJaycox%2C+Larry+B%3BAndrews%2C+Ronnee+N%3BStriley%2C+Cynthia+A+F%3BAlavanja%2C+Michael+C+R&rft.aulast=Hines&rft.aufirst=Cynthia&rft.date=2008-04-01&rft.volume=52&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men001 ER - TY - JOUR T1 - Onset of acute myocardial infarction after use of non-steroidal anti-inflammatory drugs. AN - 70468729; 18302311 AB - To examine the association between cyclooxygenase-2 (COX-2) selective and traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and incident acute myocardial infarction (AMI), and to address unanswered questions regarding the contour of risk over time. A cohort of new NSAID users aged 40-84 years was followed for the occurrence of first AMI. Data were collected within the General Practice Research Database (GPRD) from 1 January 1997 to 31 December 2004. The study population included 1185 AMI events (889 probable and 296 possible) from a cohort of 283 136 patients. After adjustment for demographic and cardiovascular risk factors, the hazard ratio (HR) for AMI was significantly increased for both coxib (2.11, 95% confidence interval (CI) 1.04-4.26) and non-coxib (2.24, 95%CI 1.13-4.42) COX-2 selective NSAIDs when compared to remote exposure to NSAIDs, but was not increased for traditional NSAIDs. Stratifying exposure into the first month of use versus use beyond 1 month, the risk of AMI was increased during the first month of COX-2 selective NSAIDs use, but not later (3.43, 95%CI 1.66-7.07 and 1.88, 95%CI 0.82-4.31, respectively p-value for interaction = 0.6). The results suggest that the use of coxib and non-coxib COX-2 selective NSAIDs was associated with an elevated risk of AMI within the first month of exposure. Recent past exposure to NSAID was not associated with a similar increase in risk. JF - Pharmacoepidemiology and drug safety AU - Hammad, Tarek A AU - Graham, David J AU - Staffa, Judy A AU - Kornegay, Cynthia J AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. tarek.hammad@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 315 EP - 321 VL - 17 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Index Medicus KW - Medical Records Systems, Computerized KW - Humans KW - Aged KW - Pharmacoepidemiology KW - United Kingdom -- epidemiology KW - Social Class KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Confidence Intervals KW - Middle Aged KW - Female KW - Male KW - Myocardial Infarction -- chemically induced KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Myocardial Infarction -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Onset+of+acute+myocardial+infarction+after+use+of+non-steroidal+anti-inflammatory+drugs.&rft.au=Hammad%2C+Tarek+A%3BGraham%2C+David+J%3BStaffa%2C+Judy+A%3BKornegay%2C+Cynthia+J%3BDal+Pan%2C+Gerald+J&rft.aulast=Hammad&rft.aufirst=Tarek&rft.date=2008-04-01&rft.volume=17&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1560 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1560 ER - TY - JOUR T1 - Indoor air quality in prisons before and after implementation of a smoking ban law. AN - 70451091; 18285386 AB - To ascertain whether a new indoor smoking ban law in North Carolina correctional facilities was successfully implemented and whether the indoor air quality has improved as a result. Before the law came into effect, we tested the air quality of 22 dormitory and common areas within six North Carolina prisons using standard protocols for testing particulate matter. We measured particulate matter 2.5 microm in diameter (PM(2.5)) using state of the art TSI SidePak monitors. After the law went into effect, the same locations within each prison were tested again. Written inmate surveys were also conducted at two prisons, one with partial smoking ban (indoors only) and one with a total smoking ban (indoors and outdoors). The findings indicate that, on average, levels of respirable suspended particulates (RSPs), an accepted marker for secondhand smoke (SHS) levels, decreased 77% in these prisons after the law took effect compared to levels obtained before ban implementation. Several areas were tobacco-free before the implementation of this ban. In those areas no significant decreases in RSPs were noted. Laws banning tobacco use in correctional facilities can significantly reduce indoor SHS exposure among inmates, visitors and staff and potentially lead to reduced use. To date, 24 US states have enacted 100% smoke-free correctional facility policies for all indoor areas even though inmates and staff have much higher tobacco use prevalence rates than the general population. With an estimated nine million people incarcerated worldwide, prison smoking bans could have a substantial impact in terms of health outcomes and long-term costs if they can effectively reduce exposure to secondhand smoke. JF - Tobacco control AU - Proescholdbell, S K AU - Foley, K L AU - Johnson, J AU - Malek, S H AD - Tobacco Prevention and Control Branch, Division of Public Health, North Carolina Department of Health and Human Services, 1932 Mail Service Center, Raleigh, NC 27699-1932, USA. scott.proescholdbell@ncmail.net Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 123 EP - 127 VL - 17 IS - 2 KW - Particulate Matter KW - 0 KW - Tobacco Smoke Pollution KW - Index Medicus KW - Humans KW - Adult KW - North Carolina -- epidemiology KW - Health Policy KW - Particulate Matter -- analysis KW - Air Pollution, Indoor -- analysis KW - Tobacco Smoke Pollution -- legislation & jurisprudence KW - Air Pollution, Indoor -- legislation & jurisprudence KW - Tobacco Smoke Pollution -- analysis KW - Prisons -- trends KW - Prisons -- legislation & jurisprudence KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70451091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Indoor+air+quality+in+prisons+before+and+after+implementation+of+a+smoking+ban+law.&rft.au=Proescholdbell%2C+S+K%3BFoley%2C+K+L%3BJohnson%2C+J%3BMalek%2C+S+H&rft.aulast=Proescholdbell&rft.aufirst=S&rft.date=2008-04-01&rft.volume=17&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftc.2007.022038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tc.2007.022038 ER - TY - JOUR T1 - Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. AN - 70431282; 18363538 AB - We describe a 71-year-old man who had received warfarin 7.5 mg/day for 5 years for atrial fibrillation, which had maintained his international normalized ratio (INR) within a narrow range of 2.5-3.2. During this 5-year period, he had also been treating himself with the supplement glucosamine hydrochloride 500 mg-chondroitin sulfate 400 mg twice/day for arthritis. The patient then increased his dosage of glucosamine to 1500 mg and chondroitin to 1200 mg twice/day; his INR previous to this change was 2.3. Approximately 3 weeks later, his INR increased to 3.9. His supplement dosage was reduced to glucosamine 750 mg-chondroitin 600 mg/day; a repeat INR done 16 days later was 4.7. The supplement was then stopped, and his warfarin schedule was changed to 7.5 mg every other day alternating with 3.75 mg every other day. Sixteen days later, his INR was 2.6. This case report suggests that a potential interaction exists between warfarin and glucosamine that is associated with an increase in the INR. We therefore performed a pharmacovigilance survey of spontaneously reported adverse events in warfarin-treated patients concomitantly exposed to glucosamine, glucosamine-chondroitin sulfate, or chondroitin sulfate and present a literature review of this apparent drug-drug interaction. Using the United States Food and Drug Administration (FDA) MedWatch database, 20 reports of glucosamine or glucosamine-chondroitin sulfate use with warfarin associated with altered coagulation (manifested by increased INR, or increased bleeding or bruising) were identified. In some cases, a decrease in the supplement dosage was followed by a return of the INR to the previous therapeutic range. Similarly, a decrease in warfarin dosage was followed by a decrease in INR in one patient who received long-term warfarin therapy. One report described an intraventricular bleed and subdural hematoma, which resulted in a persistent vegetative state. The World Health Organization (WHO) adverse drug reactions database documented 21 spontaneous reports of increased INR associated with glucosamine use, 17 of which resolved when glucosamine was stopped. We located one published case report of concomitant use of glucosamine-chondroitin sulfate potentiating the effect of warfarin. In aggregate, the reports from the FDA and WHO, the published case report, and our case report suggest that the use of warfarin and glucosamine may lead to an increased INR. Patients should be advised that the use of the two products may cause an increase in INR, and they should inform their health care provider if they consume glucosamine. More information is necessary to define this interaction. JF - Pharmacotherapy AU - Knudsen, James F AU - Sokol, Gerald H AD - Division of Neurology and Psychiatry Drug Products, Office of Drug Evaluation I, United States Food and Drug Administration, Silver Spring, MD 20993-0002, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 540 EP - 548 VL - 28 IS - 4 SN - 0277-0008, 0277-0008 KW - Anticoagulants KW - 0 KW - Drug Combinations KW - Warfarin KW - 5Q7ZVV76EI KW - Chondroitin Sulfates KW - 9007-28-7 KW - Glucosamine KW - N08U5BOQ1K KW - Index Medicus KW - Drug Interactions KW - Chondroitin Sulfates -- administration & dosage KW - Aged, 80 and over KW - Humans KW - International Normalized Ratio KW - Adult KW - Aged KW - Middle Aged KW - Dietary Supplements KW - Male KW - Female KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - Glucosamine -- pharmacology KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70431282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Potential+glucosamine-warfarin+interaction+resulting+in+increased+international+normalized+ratio%3A+case+report+and+review+of+the+literature+and+MedWatch+database.&rft.au=Knudsen%2C+James+F%3BSokol%2C+Gerald+H&rft.aulast=Knudsen&rft.aufirst=James&rft.date=2008-04-01&rft.volume=28&rft.issue=4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/10.1592%2Fphco.28.4.540 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.28.4.540 ER - TY - JOUR T1 - Fetal ultrasound: mechanical effects. AN - 70419848; 18359910 AB - In this discussion, any biological effect of ultrasound that is accompanied by temperature increments less than 1 degrees C above normal physiologic levels is called a mechanical effect. However, one should keep in mind that the term mechanical effect also includes processes that are not of a mechanical nature but arise secondary to mechanical interaction between ultrasound and tissues, such as chemical reactions initiated by free oxygen species generated during cavitation and sonoluminescence. Investigations with laboratory animals have documented that pulsed ultrasound can produce damage to biological tissues in vivo through nonthermal mechanisms. The acoustic output used to induce these adverse bio-effects is considerably greater than the output of diagnostic devices when gas bodies are not present. However, low-intensity pulsed ultrasound is used clinically to accelerate the bone fracture repair process and induce healing of nonunions in humans. Low-intensity pulsed ultrasound also has been shown to enhance repair of soft tissue damage and accelerate nerve regeneration in animal models. Although such exposures to low intensity do not appear to cause damage to exposed tissues, they do raise questions about the acoustic threshold that might induce potentially adverse developmental effects in the fetus. To date, bioeffects studies in humans do not substantiate a causal relationship between diagnostic ultrasound exposure during pregnancy and adverse biological effects to the fetus. However, the epidemiologic studies were conducted with commercially available devices predating 1992, having outputs not exceeding a derated spatial-peak temporal-average intensity (ISPTA.3) of 94 mW/cm2. Current limits in the United States allow an ISPTA.3 of 720 mW/cm2 for obstetric modes. At the time of this report, available evidence, experimental or epidemiologic, is insufficient to conclude that there is a causal relationship between obstetric diagnostic ultrasound exposure and adverse nonthermal effects to the fetus. However, low-intensity pulsed ultrasound effects reported in humans and animal models indicate a need for further investigation of potentially adverse developmental effects. JF - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine AU - Stratmeyer, Melvin E AU - Greenleaf, James F AU - Dalecki, Diane AU - Salvesen, Kjell A AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 9200 Corporate Blvd, HFZ-120, Rockville, MD 20850 USA. melvin.stratmeyer@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 597 EP - 605; quiz 606-9 VL - 27 IS - 4 SN - 0278-4297, 0278-4297 KW - Index Medicus KW - Radiation Dosage KW - Animals KW - Risk Factors KW - Humans KW - Dose-Response Relationship, Radiation KW - Female KW - Risk Assessment KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Ultrasonography, Prenatal -- adverse effects KW - Fetus -- radiation effects KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70419848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+ultrasound+in+medicine+%3A+official+journal+of+the+American+Institute+of+Ultrasound+in+Medicine&rft.atitle=Fetal+ultrasound%3A+mechanical+effects.&rft.au=Stratmeyer%2C+Melvin+E%3BGreenleaf%2C+James+F%3BDalecki%2C+Diane%3BSalvesen%2C+Kjell+A&rft.aulast=Stratmeyer&rft.aufirst=Melvin&rft.date=2008-04-01&rft.volume=27&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Journal+of+ultrasound+in+medicine+%3A+official+journal+of+the+American+Institute+of+Ultrasound+in+Medicine&rft.issn=02784297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Are literature references sufficient for dose recommendations? An FDA case study of efavirenz and rifampin. AN - 70415606; 18303126 AB - One of the numerous regulatory functions of the Food and Drug Administration (FDA) is the evaluation of drug-drug interactions and the determination of appropriate dose adjustments, if necessary, to ensure the safe and effective use of medications. The FDA considers several data sources when determining the significance of drug-drug interactions. The majority of dose adjustment recommendations are based on specific drug-drug interactions studies. The FDA reviews individual patient pharmacokinetic and safety data from drug interaction studies, determines appropriate dose adjustments, and provides recommendations to update the respective product labeling. Sometimes literature references are submitted to the FDA to support dosing recommendations. Determining an appropriate dose adjustment recommendation based on literature reports is a challenge for the FDA due to the lack of individual patient pharmacokinetic or safety data from these studies. Recently, the FDA encountered a challenging regulatory situation when evaluating literature reports to determine the appropriate dose of efavirenz and rifampin. Although numerous studies were found in the literature about this combination, a dosing recommendation cannot be concluded from the reported data. This article reviews the process the FDA used to evaluate literature to support potential dose adjustments for efavirenz when coadministered with rifampin and the challenges encountered during the process. JF - Journal of clinical pharmacology AU - DiGiacinto, Jennifer L AU - Chan-Tack, Kirk M AU - Robertson, Sarah M AU - Reynolds, Kellie S AU - Struble, Kimberly A AD - Office of Clinica Pharmacology, Division IV, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 518 EP - 523 VL - 48 IS - 4 SN - 0091-2700, 0091-2700 KW - Anti-HIV Agents KW - 0 KW - Antitubercular Agents KW - Benzoxazines KW - efavirenz KW - JE6H2O27P8 KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - United States Food and Drug Administration KW - Databases, Bibliographic KW - Humans KW - Reference Standards KW - Rifampin -- adverse effects KW - Antitubercular Agents -- administration & dosage KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Benzoxazines -- adverse effects KW - Rifampin -- administration & dosage KW - Antitubercular Agents -- adverse effects KW - Benzoxazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70415606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Are+literature+references+sufficient+for+dose+recommendations%3F+An+FDA+case+study+of+efavirenz+and+rifampin.&rft.au=DiGiacinto%2C+Jennifer+L%3BChan-Tack%2C+Kirk+M%3BRobertson%2C+Sarah+M%3BReynolds%2C+Kellie+S%3BStruble%2C+Kimberly+A&rft.aulast=DiGiacinto&rft.aufirst=Jennifer&rft.date=2008-04-01&rft.volume=48&rft.issue=4&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270008315308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-28 N1 - Date created - 2008-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270008315308 ER - TY - JOUR T1 - Mortality among U.S. underground coal miners: a 23-year follow-up. AN - 70413373; 18247381 AB - The mortality experience over 22-24 years of 8,899 working coal miners initially medically examined in 1969-1971 at 31 U.S. coal mines was evaluated. A cohort life-table analysis was undertaken on underlying causes of death, and proportional hazards models were fitted to both underlying, and underlying and contributing causes of death. Elevated mortality from nonviolent causes, nonmalignant respiratory disease (NMRD), and accidents was observed, but lung cancer and stomach cancer mortality were not elevated. Smoking, pneumoconiosis, coal rank region, and cumulative coal mine dust exposure were all predictors of mortality from nonviolent causes and NMRD. Mortality from nonviolent causes and NMRD was related to dust exposure within the complete cohort and also for the never smoker subgroup. Dust exposure relative risks for mortality were similar for pneumoconiosis, NMRD, and chronic airways obstruction. The findings confirm and enlarge upon previous results showing that exposure to coal mine dust leads to increased mortality, even in the absence of smoking. (c) 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Attfield, M D AU - Kuempel, E D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia 26505, USA. mdal@cdc.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 231 EP - 245 VL - 51 IS - 4 SN - 0271-3586, 0271-3586 KW - Dust KW - 0 KW - Index Medicus KW - Epidemiologic Studies KW - Risk Factors KW - Humans KW - Pneumoconiosis -- epidemiology KW - Adult KW - Lung Diseases -- epidemiology KW - Lung Diseases -- mortality KW - United States -- epidemiology KW - Male KW - Cause of Death KW - Occupational Health KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Coal Mining KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70413373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Mortality+among+U.S.+underground+coal+miners%3A+a+23-year+follow-up.&rft.au=Attfield%2C+M+D%3BKuempel%2C+E+D&rft.aulast=Attfield&rft.aufirst=M&rft.date=2008-04-01&rft.volume=51&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20560 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-20 N1 - Date created - 2008-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Ind Med. 2010 May;53(5):550 [20187009] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20560 ER - TY - JOUR T1 - Substance abuse in pregnant women: making improved detection a good clinical outcome. AN - 70412221; 18349872 AB - In this issue, Gideon Koren and colleagues review the maternal and child health implications of drug-residue testing in maternal and neonatal hair and testing for drugs in meconium. Since the 1990s, these methods have been used to varying degrees in clinical practice, but recent technological advances have increased their accuracy and usability in the clinical setting. Compared with self-reported maternal use, drug-residue testing in hair and testing for drugs in meconium are more reliable methods for detecting drug and alcohol exposure during pregnancy. These methods can also provide insights into patterns of use and abuse of these substances. JF - Clinical pharmacology and therapeutics AU - Araojo, R AU - McCune, S AU - Feibus, K AD - Maternal Health Team, Pediatric and Maternal Health Staff, Office of New Drugs-Immediate Office, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 520 EP - 522 VL - 83 IS - 4 KW - Biomarkers KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Meconium -- chemistry KW - Humans KW - Hair -- chemistry KW - Biomarkers -- analysis KW - Adult KW - Infant, Newborn KW - Adolescent KW - Female KW - Pregnancy KW - Substance-Related Disorders -- diagnosis KW - Pregnancy Complications -- diagnosis KW - Prenatal Exposure Delayed Effects -- diagnosis KW - Substance Abuse Detection -- methods KW - Substance Abuse Detection -- ethics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70412221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Substance+abuse+in+pregnant+women%3A+making+improved+detection+a+good+clinical+outcome.&rft.au=Araojo%2C+R%3BMcCune%2C+S%3BFeibus%2C+K&rft.aulast=Araojo&rft.aufirst=R&rft.date=2008-04-01&rft.volume=83&rft.issue=4&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Clin Pharmacol Ther. 2008 Apr;83(4):631-4 [18288086] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.13 ER - TY - JOUR T1 - Respiratory inflammatory responses among occupants of a water-damaged office building. AN - 70383899; 18333992 AB - The National Institute for Occupational Safety and Health (NIOSH) received a request for evaluation of a water-damaged office building which housed approximately 1300 employees. Workers reported respiratory conditions that they perceived to be building related. We hypothesized that these symptoms were associated with airways inflammation. To test this hypothesis, we assessed airways inflammation in employees using exhaled breath condensate (EBC) and the fraction of exhaled nitric oxide (FENO). In September 2001, a health questionnaire was offered to all employees. Based on this questionnaire, NIOSH invited 356 symptomatic and asymptomatic employees to participate in a medical survey. In June 2002, these employees were offered questionnaire, spirometry, methacholine challenge test, allergen skin prick testing, EBC and FENO. FENO or EBC were completed by 239 participants. As smoking is highly related to the measurements that we used in this study, we included only the 207 current non-smokers in the analyses. EBC interleukin-8 (IL-8) levels, but not nitrite, were significantly higher among workers with respiratory symptoms and in the physician-diagnosed asthmatic group. Of the analyses assessed, EBC IL-8 showed the most significant relationship with a number of symptoms and physician-diagnosed asthma. Implementation of exhaled breath condensate and exhaled nitric oxide in indoor air quality problems. JF - Indoor air AU - Akpinar-Elci, M AU - Siegel, P D AU - Cox-Ganser, J M AU - Stemple, K J AU - White, S K AU - Hilsbos, K AU - Weissman, D N AD - CDC/NIOSH Division of Respiratory Diseases Studies, Morgantown, WV, USA. makpinarelci@gmail.com Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 125 EP - 130 VL - 18 IS - 2 KW - Interleukin-8 KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - United States KW - Exhalation KW - Humans KW - Skin Tests KW - Nitric Oxide -- metabolism KW - Workplace KW - Fungi -- growth & development KW - National Institute for Occupational Safety and Health (U.S.) KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Interleukin-8 -- metabolism KW - Female KW - Male KW - Sick Building Syndrome -- etiology KW - Sick Building Syndrome -- microbiology KW - Airway Obstruction -- etiology KW - Air Pollution, Indoor -- adverse effects KW - Occupational Diseases -- metabolism KW - Respiratory Hypersensitivity -- etiology KW - Airway Obstruction -- microbiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Respiratory Hypersensitivity -- metabolism KW - Respiratory Hypersensitivity -- microbiology KW - Occupational Diseases -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70383899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+air&rft.atitle=Respiratory+inflammatory+responses+among+occupants+of+a+water-damaged+office+building.&rft.au=Akpinar-Elci%2C+M%3BSiegel%2C+P+D%3BCox-Ganser%2C+J+M%3BStemple%2C+K+J%3BWhite%2C+S+K%3BHilsbos%2C+K%3BWeissman%2C+D+N&rft.aulast=Akpinar-Elci&rft.aufirst=M&rft.date=2008-04-01&rft.volume=18&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Indoor+air&rft.issn=1600-0668&rft_id=info:doi/10.1111%2Fj.1600-0668.2007.00514.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0668.2007.00514.x ER - TY - JOUR T1 - Occupational risk management of engineered nanoparticles. AN - 70277531; 18260001 AB - The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring. JF - Journal of occupational and environmental hygiene AU - Schulte, Paul AU - Geraci, Charles AU - Zumwalde, Ralph AU - Hoover, Mark AU - Kuempel, Eileen AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226-1998, USA. pas4@cdc.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 239 EP - 249 VL - 5 IS - 4 KW - Index Medicus KW - Environmental Monitoring KW - Ventilation -- methods KW - Protective Clothing KW - Humans KW - Risk Assessment KW - Nanotechnology KW - Occupational Health KW - Occupational Exposure -- prevention & control KW - Nanoparticles -- analysis KW - Risk Management KW - Nanoparticles -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70277531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Occupational+risk+management+of+engineered+nanoparticles.&rft.au=Schulte%2C+Paul%3BGeraci%2C+Charles%3BZumwalde%2C+Ralph%3BHoover%2C+Mark%3BKuempel%2C+Eileen&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-04-01&rft.volume=5&rft.issue=4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620801907840 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2008-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620801907840 ER - TY - JOUR T1 - Suspension tolerance in a full-body safety harness, and a prototype harness accessory. AN - 70273199; 18247226 AB - Workers wearing full-body safety harnesses are at risk for suspension trauma if they are not rescued in 5 to 30 min after a successfully arrested fall. Suspension trauma, which may be fatal, occurs when a person's legs are immobile in a vertical posture, leading to the pooling of blood in the legs, pelvis, and abdomen, and the reduction of return blood flow to the heart and brain. To measure suspension tolerance time, 22 men and 18 women with construction experience were suspended from the chest D-ring (CHEST) and back D-ring (BACK) of full-body, fall-arrest harnesses. Fifteen men and 13 women from the original group of subjects were then suspended using a newly developed National Institute for Occupational Safety and Health harness accessory (ACCESS), which supports the upper legs. Midthigh circumference changes were 1.4 and 1.9 cm, changes in minute ventilation were 1.2 and 1.5 L/min, changes in heart rate (HR) were 15.1 and 21.6 bpm, and changes in mean arterial pressure were 5.1 and -2.6 mmHg (p < or = 0.05) for all subjects during CHEST and BACK, respectively. Kaplan-Meier median suspension time for all subjects for the CHEST condition was 29 min (range 4-60 min) and 31 min (range 5-56 min) for the BACK condition. The 95th percentile for suspension time was 7 min for CHEST and 11 min for BACK. Cox regression revealed that body weight had a statistically significant effect on the time until experiencing a medical end point (p < or = 0.05) during the BACK condition. Mean (+/- SD) suspension time was 58 +/- 6 min (range 39-60 min) for all subjects for the ACCESS condition. There were no terminations due to medical symptoms during the ACCESS suspension, changes in physiological variables were small, and 85% of ACCESS subjects completed 60-min suspensions. These data provide information on motionless suspension tolerance time to standards-setting organizations and demonstrate the potential of a prototype harness accessory to delay or prevent suspension trauma. JF - Journal of occupational and environmental hygiene AU - Turner, Nina L AU - Wassell, James T AU - Whisler, Richard AU - Zwiener, Joyce AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia 26505, USA. nturner@cdc.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 227 EP - 231 VL - 5 IS - 4 KW - Index Medicus KW - Kaplan-Meier Estimate KW - Human Engineering KW - Heart Rate KW - Equipment Design KW - Blood Pressure KW - Humans KW - Adult KW - Male KW - Female KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Accidental Falls KW - Immobilization -- adverse effects KW - Protective Devices -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70273199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Suspension+tolerance+in+a+full-body+safety+harness%2C+and+a+prototype+harness+accessory.&rft.au=Turner%2C+Nina+L%3BWassell%2C+James+T%3BWhisler%2C+Richard%3BZwiener%2C+Joyce&rft.aulast=Turner&rft.aufirst=Nina&rft.date=2008-04-01&rft.volume=5&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620801894386 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620801894386 ER - TY - JOUR T1 - Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy. AN - 69168460; 18448560 AB - Management of anthracycline extravasation is problematic and most reports are anecdotal. On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy. In two studies, a total of 57 evaluable patients experienced extravasation from peripheral vein or central venous access sites with local swelling, pain, or redness. The presence of anthracycline in skin biopsy tissue was confirmed by tissue fluorescence, and treatment with a 3-day schedule of dexrazoxane began within 6 hours of the event. The primary endpoint was a reduction in the need for surgical intervention. Only one patient required surgical repair of the injury site, and late sequelae in the remainder were absent or mild. Also, the sponsor, TopoTarget A/S, Copenhagen, Denmark, performed controlled nonclinical studies in support of dexrazoxane dose and timing for the reduction of tissue injury resulting from anthracycline extravasation. For this uncommon but serious complication of anthracycline therapy, the need for surgical intervention was 1.7% with this regimen. JF - The oncologist AU - Kane, Robert C AU - McGuinn, W David AU - Dagher, Ramzi AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Bldg. 22, Room 2109, Silver Spring, Maryland 20993-0002, USA. robert.kane@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 445 EP - 450 VL - 13 IS - 4 SN - 1083-7159, 1083-7159 KW - Anthracyclines KW - 0 KW - Antibiotics, Antineoplastic KW - Razoxane KW - 5AR83PR647 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Risk Factors KW - Humans KW - Drug Approval KW - Infusions, Intravenous -- adverse effects KW - Razoxane -- therapeutic use KW - Antibiotics, Antineoplastic -- administration & dosage KW - Extravasation of Diagnostic and Therapeutic Materials KW - Anthracyclines -- administration & dosage KW - Anthracyclines -- adverse effects KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69168460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Dexrazoxane+%28Totect%29%3A+FDA+review+and+approval+for+the+treatment+of+accidental+extravasation+following+intravenous+anthracycline+chemotherapy.&rft.au=Kane%2C+Robert+C%3BMcGuinn%2C+W+David%3BDagher%2C+Ramzi%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2008-04-01&rft.volume=13&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2007-0247 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-17 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2007-0247 ER - TY - JOUR T1 - Genetic contributions to influenza virus attenuation in the rat brain. AN - 69148154; 18444085 AB - Influenza is generally regarded as an infection of the respiratory tract; however, neurological involvement is a well-recognized, although uncommon, complication of influenza A virus infection. The authors previously described the development of a rat model for studying influenza virus infection of the central nervous system (CNS). This model was used here to study the role of virus genes in virus replication and spread in brain. In the present work, an infectious cDNA clone of the neurotoxic WSN strain of influenza virus (rWSN) was altered by site-directed mutagenesis at five loci that corresponded to changes previously shown to confer temperature sensitivity and attenuation of the A/Ann Arbor/6/60 strain (PB1Delta 391, PB1Delta 581, and PB1Delta 661; PB2Delta 265, and NPDelta 34). Whereas rWSN and its mutated derivative (mu-rWSN) replicated equally well in MDCK cells at 37 degrees C (the body temperature of rats), rWSN grew to higher titers and infection was more widespread compared to mu-rWSN in rat brain. These results demonstrate that the five mutations that confer attenuation of the A/Ann Arbor/6/60 influenza virus strain for the respiratory system also confer attenuation for the central nervous system. Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis. JF - Journal of neurovirology AU - Qi, Li AU - Carbone, Kathryn M AU - Ye, Zhiping AU - Liu, Teresa AU - Ovanesov, Mikhail AU - Pletnikov, Mikhail AU - Sauder, Christian AU - Rubin, Steven A AD - CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 136 EP - 142 VL - 14 IS - 2 KW - Viral Proteins KW - 0 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - Temperature KW - Orthomyxoviridae Infections -- immunology KW - Virus Replication KW - Viral Proteins -- immunology KW - Viral Proteins -- genetics KW - Influenza A virus -- physiology KW - Central Nervous System -- virology KW - Virulence -- genetics KW - Viral Proteins -- biosynthesis KW - Genes, Viral KW - Influenza A virus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69148154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurovirology&rft.atitle=Genetic+contributions+to+influenza+virus+attenuation+in+the+rat+brain.&rft.au=Qi%2C+Li%3BCarbone%2C+Kathryn+M%3BYe%2C+Zhiping%3BLiu%2C+Teresa%3BOvanesov%2C+Mikhail%3BPletnikov%2C+Mikhail%3BSauder%2C+Christian%3BRubin%2C+Steven+A&rft.aulast=Qi&rft.aufirst=Li&rft.date=2008-04-01&rft.volume=14&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurovirology&rft.issn=1538-2443&rft_id=info:doi/10.1080%2F13550280701885563 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/13550280701885563 ER - TY - JOUR T1 - Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity. AN - 69118775; 18276636 AB - Replication of the mitochondrial genome by DNA polymerase gamma requires dNTP precursors that are subject to oxidation by reactive oxygen species generated by the mitochondrial respiratory chain. One such oxidation product is 8-oxo-dGTP, which can compete with dTTP for incorporation opposite template adenine to yield A-T to C-G transversions. Recent reports indicate that the ratio of undamaged dGTP to dTTP in mitochondrial dNTP pools from rodent tissues varies from approximately 1:1 to >100:1. Within this wide range, we report here the proportion of 8-oxo-dGTP in the dNTP pool that would be needed to reduce the replication fidelity of human DNA polymerase gamma. When various in vivo mitochondrial dNTP pools reported previously were used here in reactions performed in vitro, 8-oxo-dGTP was readily incorporated opposite template A and the resulting 8-oxo-G-A mismatch was not proofread efficiently by the intrinsic 3' exonuclease activity of pol gamma. At the dNTP ratios reported in rodent tissues, whether highly imbalanced or relatively balanced, the amount of 8-oxo-dGTP needed to reduce fidelity was <1% of dGTP. Moreover, direct measurements reveal that 8-oxo-dGTP is present at such concentrations in the mitochondrial dNTP pools of several rat tissues. The results suggest that oxidized dNTP precursors may contribute to mitochondrial mutagenesis in vivo, which could contribute to mitochondrial dysfunction and disease. JF - Nucleic acids research AU - Pursell, Zachary F AU - McDonald, J Tyson AU - Mathews, Christopher K AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 2174 EP - 2181 VL - 36 IS - 7 KW - DNA, Mitochondrial KW - 0 KW - Deoxyguanine Nucleotides KW - Deoxyribonucleotides KW - 8-oxodeoxyguanosine triphosphate KW - 139307-94-1 KW - deoxyguanosine triphosphate KW - 8C2O37Y44Q KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Wistar KW - Deoxyribonucleotides -- metabolism KW - Mitochondria -- metabolism KW - Mice KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- genetics KW - Male KW - Deoxyguanine Nucleotides -- metabolism KW - DNA, Mitochondrial -- chemistry KW - DNA, Mitochondrial -- biosynthesis KW - DNA Replication KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69118775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Trace+amounts+of+8-oxo-dGTP+in+mitochondrial+dNTP+pools+reduce+DNA+polymerase+gamma+replication+fidelity.&rft.au=Pursell%2C+Zachary+F%3BMcDonald%2C+J+Tyson%3BMathews%2C+Christopher+K%3BKunkel%2C+Thomas+A&rft.aulast=Pursell&rft.aufirst=Zachary&rft.date=2008-04-01&rft.volume=36&rft.issue=7&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-19 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1989 Feb 7;28(3):988-95 [2713377] Lancet. 1989 Mar 25;1(8639):642-5 [2564461] Proc Natl Acad Sci U S A. 1990 Jun;87(12):4533-7 [2352934] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nature. 1992 Jan 16;355(6357):273-5 [1309939] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11021-5 [1332067] Biochemistry. 1994 Apr 19;33(15):4695-701 [8161527] J Biol Chem. 1995 Jun 16;270(24):14659-65 [7782328] J Biol Chem. 1995 Oct 27;270(43):25942-8 [7592783] Methods Enzymol. 1995;262:217-32 [8594349] Biochem J. 1996 Jan 1;313 ( Pt 1):17-29 [8546679] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4990-5 [15784738] J Biol Chem. 2005 Jul 1;280(26):24472-80 [15878850] Science. 2005 Jul 15;309(5733):481-4 [16020738] Structure. 2005 Nov;13(11):1653-9 [16271888] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] J Biol Chem. 2006 Nov 24;281(47):36241-8 [17005553] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18586-91 [17124168] Lab Invest. 2007 Apr;87(4):326-35 [17310215] Nat Genet. 2007 Apr;39(4):540-3 [17334366] Nucleic Acids Res. 2007;35(9):3076-86 [17452367] FASEB J. 2007 Aug;21(10):2294-303 [17403938] Hum Mol Genet. 2007 Nov 15;16(22):2729-39 [17725985] Science. 1999 Oct 22;286(5440):774-9 [10531063] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2002 May 3;277(18):15807-12 [11856756] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Structure. 2003 Jan;11(1):121-7 [12517346] EMBO Rep. 2003 Mar;4(3):269-73 [12634844] J Biol Chem. 2003 Sep 26;278(39):37965-73 [12857738] J Biol Chem. 2004 Apr 23;279(17):17019-26 [14747464] Nature. 2004 May 27;429(6990):417-23 [15164064] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] J Biol Chem. 1988 Mar 25;263(9):4450-9 [2831231] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6469-73 [2671990] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn062 ER - TY - JOUR T1 - NIEHS extramural global environmental health portfolio: opportunities for collaboration. AN - 69102273; 18414621 AB - Global environmental health has emerged as a critical topic for environmental health researchers and practitioners. Estimates of the environmental contribution of total worldwide disease burden range from 25 to 33%. We reviewed grants funded by the National Institute of Environmental Health Sciences (NIEHS) during 2005-2007 to evaluate the costs and scientific composition of the global environmental health portfolio, with the ultimate aim of strengthening global environmental health research partnerships. We examined NIEHS grant research databases to identify the global environmental health portfolio. In the past 3 fiscal years (2005-2007), the NIEHS funded 57 scientific research projects in 37 countries, at an estimated cost of $30 million. Metals such as arsenic, methylmercury, and lead are the most frequently studied toxic agents, but a wide range of stressors, routes of exposure, and agents are addressed in the portfolio. The portfolio analysis indicates that there is a firm foundation of research activities upon which additional global environmental health partnerships could be encouraged. Current data structures could be strengthened to support more automated analysis of grantee information. JF - Environmental health perspectives AU - Drew, Christina H AU - Barnes, Martha I AU - Phelps, Jerry AU - Van Houten, Bennett AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. drewc@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 421 EP - 425 VL - 116 IS - 4 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Metals KW - Index Medicus KW - partnerships KW - global health KW - science assessment KW - Humans KW - Research Support as Topic KW - Metals -- toxicity KW - Global Health KW - Research -- organization & administration KW - Environmental Pollutants -- toxicity KW - Environmental Exposure -- adverse effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=NIEHS+extramural+global+environmental+health+portfolio%3A+opportunities+for+collaboration.&rft.au=Drew%2C+Christina+H%3BBarnes%2C+Martha+I%3BPhelps%2C+Jerry%3BVan+Houten%2C+Bennett&rft.aulast=Drew&rft.aufirst=Christina&rft.date=2008-04-01&rft.volume=116&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11323 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-11 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 1999 Sep;10(5):573-84 [10468437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11323 ER - TY - RPRT T1 - Developmental Status and Early Intervention Service Needs of Maltreated Children. Final Report AN - 61965222; ED501753 AB - This report describes the extent to which maltreated children have developmental problems or are subject to factors associated with poor developmental outcomes, what services these children might be eligible to receive, what factors influence service receipt, and what solutions have been devised to address barriers to service provision. This final report presents findings from an analysis of the "National Early Intervention Longitudinal Study" (NEILS) and the "National Survey of Child and Adolescent Well-Being" (NSCAW) to provide information about the developmental status and early intervention service needs of children under age three who are substantiated for maltreatment. The study found that: (1) children ages birth to 36 months who have been maltreated are at substantial risk of experiencing subsequent developmental problems; (2) compared to classification at the time of initial contact with Child Welfare Services, over time a higher proportion of children are described as having fewer risks or with a low score on a developmental measure while over time a smaller proportion of children are described as having more risks; (3) few infants and toddlers with substantiated cases of maltreatment are reported to have a diagnosed medical condition (an established risk condition) as described in IDEA (e.g., Down syndrome, blindness, cerebral palsy) that would make them automatically eligible for Part C services; (4) among children who have substantiated maltreatment, the proportion with a low score on a developmental measure does not differ markedly from those of children investigated but not found to have substantiated maltreatment; (5) maltreated children between 24 to 36 months of age have relatively high levels of behavior problems reported by their caregivers; (6) a sizeable proportion of infants and toddlers with substantiated maltreatment were reported to have an Individualized Family Service Plan (IFSP), reflecting eligibility for Part C services; (7) families are receiving parent training and family counseling services through Child Welfare Services or by referral. It is unclear the extent to which these services provide interventions focused on enhancing child development; (8) Part C providers may not be familiar with the unique challenges associated with providing services to maltreated children and their families; and (9) increased training and collaboration of Child Welfare and Part C service providers may be a useful approach to facilitate CAPTA compliance and enhance developmental outcomes for children. This study confirms that the level of risk for developmental delay is high for maltreated children and that it remains high, years after the initial maltreatment. (Contains 15 exhibits.) AU - Barth, Richard P. AU - Scarborough, Anita A. AU - Lloyd, Christopher E. AU - Losby, Jan L. AU - Casanueva, Cecilia AU - Mann, Tammy Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 70 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Individuals with Disabilities Education Act KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Parent Education KW - At Risk Persons KW - Toddlers KW - Young Children KW - Individual Characteristics KW - Individualized Family Service Plans KW - Developmental Delays KW - Counseling Services KW - Intervention KW - Child Welfare KW - Behavior Problems KW - Eligibility KW - Health Needs KW - Federal Legislation KW - Family Programs KW - Early Intervention KW - Social Services KW - Child Development KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61965222?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Evaluation of Gatekeeper Training for Suicide Prevention in Veterans AN - 57246031; 200822141 AB - Clinical providers and 'front line' nonclinical staff who work with veterans, families, and communities are natural gatekeepers to identify and to refer veterans at risk for suicide. A national cohort (n=602) of community based counseling center staff from the U.S. Department of Veterans Affairs (VA) participated in an evaluation of a brief standardized gatekeeper training program and a scripted behavioral rehearsal practice session. A significant difference in knowledge and self efficacy was observed from pre to post (p<.0001) with the nonclinicians showing larger effect sizes for knowledge (0.96 vs. 0.42) and self efficacy (0.89 vs. 0.41). Gatekeeper training for suicide prevention shows promise for increasing the capacity of VA staff to work with at risk veterans. JF - Archives of Suicide Research AU - Matthieu, Monica M AU - Cross, Wendi AU - Batres, Alfonso R AU - Flora, Charles M AU - Knox, Kerry L AD - Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 148 EP - 154 PB - Taylor & Francis, Philadelphia PA VL - 12 IS - 2 SN - 1381-1118, 1381-1118 KW - Assessment KW - Lay people KW - Veterans KW - Referrals KW - Suicide KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57246031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Suicide+Research&rft.atitle=Evaluation+of+Gatekeeper+Training+for+Suicide+Prevention+in+Veterans&rft.au=Matthieu%2C+Monica+M%3BCross%2C+Wendi%3BBatres%2C+Alfonso+R%3BFlora%2C+Charles+M%3BKnox%2C+Kerry+L&rft.aulast=Matthieu&rft.aufirst=Monica&rft.date=2008-04-01&rft.volume=12&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Archives+of+Suicide+Research&rft.issn=13811118&rft_id=info:doi/10.1080%2F13811110701857491 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - ASREFQ N1 - SubjectsTermNotLitGenreText - Veterans; Preventive programmes; Lay people; Assessment; Suicide; Referrals DO - http://dx.doi.org/10.1080/13811110701857491 ER - TY - JOUR T1 - Prediction of Heat-Illness Symptoms with the Prediction of Human Vascular Response in Hot Environment Under Resting Condition AN - 216793198; 18461820 AB - The thermoregulatory control of human skin blood flow is vital to maintain the body heat storage during challenges of thermal homeostasis under heat stress. Whenever thermal homeostasis disturbed, the heat load exceeds heat dissipation capacity, which alters the cutaneous vascular responses along with other body physiological variables. Whole body skin blood flow has been calculated from the forearm blood flow. Present model has been designed using electronics circuit simulator (Multisim 8.0, National Instruments, USA), is to execute a series of predictive equations for early prediction of physiological parameters of young nude subjects during resting condition at various level of dry heat stress under almost still air to avoid causalities associated with hot environmental. The users can execute the model by changing the environmental temperature in °C and exposure time in minutes. The model would be able to predict and detect the changes in human vascular responses along with other physiological parameters and from this predicted values heat related-illness symptoms can be inferred. [PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 167 EP - 76 CY - New York PB - Springer Science & Business Media VL - 32 IS - 2 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Temperature KW - Physiology KW - Heatstroke KW - Humans KW - Body Temperature Regulation -- physiology KW - Skin -- blood supply KW - Hot Temperature KW - Rest -- physiology KW - Blood Vessels -- radiation effects KW - Predictive Value of Tests KW - Heat Stroke UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/216793198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Prediction+of+Heat-Illness+Symptoms+with+the+Prediction+of+Human+Vascular+Response+in+Hot+Environment+Under+Resting+Condition&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2008-04-01&rft.volume=32&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9119-3 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2008 N1 - Document feature - References N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-007-9119-3 ER - TY - JOUR T1 - Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells AN - 21067311; 8632284 AB - This study presents computerized automatic image analysis for quantitatively evaluating dynamic contrast-enhanced MRI in an ischemic rat hindlimb model. MRI at 7T was performed on animals in a blinded placebo-controlled experiment comparing multipotent adult progenitor cell-derived progenitor cell (MDPC)-treated, phosphate buffered saline (PBS)-injected, and sham-operated rats. Ischemic and non-ischemic limb regions of interest were automatically segmented from time-series images for detecting changes in perfusion and late enhancement. In correlation analysis of the time-signal intensity histograms, the MDPC-treated limbs correlated well with their corresponding non-ischemic limbs. However, the correlation coefficient of the PBS control group was significantly lower than that of the MDPC-treated and sham-operated groups. In semi-quantitative parametric maps of contrast enhancement, there was no significant difference in hypo-enhanced area between the MDPC and PBS groups at early perfusion-dependent time frames. However, the late-enhancement area was significantly larger in the PBS than the MDPC group. The results of this exploratory study show that MDPC-treated rats could be objectively distinguished from PBS controls. The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI. Published in 2007 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Hsu, Li-Yueh AU - Wragg, Andrew AU - Anderson, Stasia A AU - Balaban, Robert S AU - Boehm, Manfred AU - Arai, Andrew E AD - National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, araia@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 111 EP - 119 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 21 IS - 2 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Perfusion KW - Limbs KW - Phosphate KW - Magnetic resonance imaging KW - Animal models KW - Image processing KW - N.M.R. KW - Correlation analysis KW - Ischemia KW - Maps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Automatic+assessment+of+dynamic+contrast-enhanced+MRI+in+an+ischemic+rat+hindlimb+model%3A+an+exploratory+study+of+transplanted+multipotent+progenitor+cells&rft.au=Hsu%2C+Li-Yueh%3BWragg%2C+Andrew%3BAnderson%2C+Stasia+A%3BBalaban%2C+Robert+S%3BBoehm%2C+Manfred%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2008-04-01&rft.volume=21&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1166 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Limbs; Magnetic resonance imaging; Stem cells; Ischemia; Animal models; Perfusion; Maps; N.M.R.; Image processing; Correlation analysis; Phosphate DO - http://dx.doi.org/10.1002/nbm.1166 ER - TY - JOUR T1 - FDA perspective on antivirals against biothreats: Communicate early and often AN - 21025540; 8254163 AB - Development of antiviral products for certain highly pathogenic viruses with limited available treatments, such as viruses that may have biothreat potential, is critically important and challenging. The mission of the FDA is to protect the public health by assuring the safety, efficacy and quality of such products. Human clinical trials are critically important whenever relevant naturally occurring diseases can appropriately be studied. In selected situations when clinical studies are not ethical and field efficacy studies are not feasible, the Animal Rule (67 FR 37988, 2002) introduces the possibility of drug/biologic approval/licensure based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. This approach necessitates the development of well-delineated animal models predictive of human disease and treatment responses, and plans for adding human information if suitable circumstances arise. Efficient development of therapeutics against these agents requires collaborative efforts among industry, academia and federal agencies. JF - Antiviral Research AU - Roberts, R AU - Styrt, B AU - McCune, S AD - Center for Drug Evaluation and Research, Office of Counter-Terrorism and Emergency Coordination, 10903 New Hampshire Avenue, White Oak Campus, Silver Spring, MD 20993, United States, rosemary.roberts@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 60 EP - 63 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Antiviral agents KW - Ethics KW - Animal models KW - Drug development KW - Clinical trials KW - Pharmacokinetics KW - Public health KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21025540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=FDA+perspective+on+antivirals+against+biothreats%3A+Communicate+early+and+often&rft.au=Roberts%2C+R%3BStyrt%2C+B%3BMcCune%2C+S&rft.aulast=Roberts&rft.aufirst=R&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antiviral agents; Ethics; Animal models; Drug development; Clinical trials; Pharmacokinetics; Public health DO - http://dx.doi.org/10.1016/j.antiviral.2007.10.001 ER - TY - JOUR T1 - Determination of Molecular Phylogenetics of Vibrio parahaemolyticus Strains by Multilocus Sequence Typing AN - 20964884; 8199429 AB - Vibrio parahaemolyticus is an important human pathogen whose transmission is associated with the consumption of contaminated seafood. There is a growing public health concern due to the emergence of a pandemic strain causing severe outbreaks worldwide. Many questions remain unanswered regarding the evolution and population structure of V. parahaemolyticus. In this work, we describe a multilocus sequence typing (MLST) scheme for V. parahaemolyticus based on the internal fragment sequences of seven housekeeping genes. This MLST scheme was applied to 100 V. parahaemolyticus strains isolated from geographically diverse clinical (n = 37) and environmental (n = 63) sources. The sequences obtained from this work were deposited and are available in a public database (http://pubmlst.org/vparahaemolyticus). Sixty-two unique sequence types were identified, and most (50) were represented by a single isolate, suggesting a high level of genetic diversity. Three major clonal complexes were identified by eBURST analysis. Separate clonal complexes were observed for V. parahaemolyticus isolates originating from the Pacific and Gulf coasts of the United States, while a third clonal complex consisted of strains belonging to the pandemic clonal complex with worldwide distribution. The data reported in this study indicate that V. parahaemolyticus is genetically diverse with a semiclonal population structure and an epidemic structure similar to that of Vibrio cholerae. Genetic diversity in V. parahaemolyticus appears to be driven primarily by frequent recombination rather than mutation, with recombination ratios estimated at 2.5:1 and 8.8:1 by allele and site, respectively. Application of this MLST scheme to more V. parahaemolyticus strains and by different laboratories will facilitate production of a global picture of the epidemiology and evolution of this pathogen. JF - Journal of Bacteriology AU - Gonzalez-Escalona, Narjol AU - Martinez-Urtaza, Jaime AU - Romero, Jaime AU - Espejo, Romilio T AU - Jaykus, Lee-Ann AU - DePaola, Angelo AD - Department of Food Science, North Carolina State University, Raleigh, North Carolina. Instituto de Acuicultura, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Spain. Laboratorio de Biotecnologia, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile. Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama. Center for Food and Applied Nutrition, Food and Drug Administration, College Park, Maryland Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 2831 EP - 2840 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 8 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Phylogeny KW - Epidemics KW - Data processing KW - Genetic diversity KW - Pathogens KW - Public health KW - multilocus sequence typing KW - Disease transmission KW - Vibrio cholerae KW - Recombination KW - Databases KW - pandemics KW - Epidemiology KW - Vibrio parahaemolyticus KW - Population structure KW - Seafood KW - Mutation KW - Evolution KW - Coasts KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20964884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Determination+of+Molecular+Phylogenetics+of+Vibrio+parahaemolyticus+Strains+by+Multilocus+Sequence+Typing&rft.au=Gonzalez-Escalona%2C+Narjol%3BMartinez-Urtaza%2C+Jaime%3BRomero%2C+Jaime%3BEspejo%2C+Romilio+T%3BJaykus%2C+Lee-Ann%3BDePaola%2C+Angelo&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2008-04-01&rft.volume=190&rft.issue=8&rft.spage=2831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Data processing; Epidemics; Genetic diversity; Pathogens; Disease transmission; multilocus sequence typing; Public health; Databases; Recombination; pandemics; Epidemiology; Population structure; Seafood; Mutation; Evolution; Coasts; Vibrio cholerae; Vibrio parahaemolyticus ER - TY - JOUR T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes IV: An Index of Chromosomal Damage in the Rhesus Monkey (Macaca mulatta) AN - 20924627; 8090211 AB - We report evaluation in rhesus monkeys of a flow cytometric procedure (MicroFlow) that has previously been shown to allow assessment of micronucleated reticulocytes (MN-RETs) in the peripheral blood of rats and dogs. Reticulocytes (RETs) were labeled with anti-CD71-fluorescein isothiocyanate, DNA was stained with propidium iodide using RNase treatment, and anti-CD61-phycoerythrin was used to reduce interference from platelets. Flow cytometric data were compared with microscopic scores of peripheral blood and bone marrow using standard acridine orange staining. A single iv administration of cyclophosphamide (CP, 5 mg/kg) induced an approximately 10-fold increase in blood MN-RET frequency, with the peak occurring 2 days after administration. After daily CP treatment to approximate a steady-state condition, the frequency of MN-RETs in peripheral blood was approximately 25% of that in bone marrow, indicating strong selection against MN-RETs. Nonetheless, CP-treated animals exhibited markedly elevated blood MN-RET values (2.45-3.99%, n = 3; compared to a mean baseline of 0.12%, n = 6). These measurements closely reflected the increased frequencies observed in the bone marrow compartment (Spearman correlation coefficient = 0.9856, n = 6). These data suggest that MN-RET measurements in blood are suitable for assessing chemical-induced chromosomal damage and can be readily integrated into routine toxicity tests, allowing genotoxicity data to be obtained as an integral part of toxicity evaluations. Microscopy-based scoring is challenging due to the low frequency of RETs and MN-RET in monkeys, but sufficient numbers of cells are easily scored with the flow cytometric procedure. JF - Toxicological Sciences AU - Hotchkiss, Charlotte E AU - Bishop, Michelle E AU - Dertinger, Stephen D AU - Slikker, William Jr AU - Moore, Martha M AU - MacGregor, James T AD - The Bionetics Corporation, Jefferson, Arkansas72079. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, 72079. Litron Laboratories, Rochester, New York, 14623. National Center for Toxicological Research, U.S. Food and Drug Administration, Rockville, Maryland, 20857 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 352 EP - 358 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 102 IS - 2 SN - 1096-6080, 1096-6080 KW - Rhesus macaque KW - Rhesus monkey KW - Genetics Abstracts; Toxicology Abstracts KW - Acridine orange KW - Data processing KW - propidium iodide KW - Genotoxicity KW - Micronuclei KW - Bone marrow KW - Peripheral blood KW - Cyclophosphamide KW - Flow cytometry KW - Platelets KW - DNA KW - Ribonuclease KW - Macaca mulatta KW - Reticulocytes KW - isothiocyanate KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20924627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Flow+Cytometric+Analysis+of+Micronuclei+in+Peripheral+Blood+Reticulocytes+IV%3A+An+Index+of+Chromosomal+Damage+in+the+Rhesus+Monkey+%28Macaca+mulatta%29&rft.au=Hotchkiss%2C+Charlotte+E%3BBishop%2C+Michelle+E%3BDertinger%2C+Stephen+D%3BSlikker%2C+William+Jr%3BMoore%2C+Martha+M%3BMacGregor%2C+James+T&rft.aulast=Hotchkiss&rft.aufirst=Charlotte&rft.date=2008-04-01&rft.volume=102&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acridine orange; Data processing; propidium iodide; Micronuclei; Genotoxicity; Bone marrow; Peripheral blood; Cyclophosphamide; Flow cytometry; DNA; Platelets; Ribonuclease; Reticulocytes; isothiocyanate; Macaca mulatta ER - TY - JOUR T1 - Irritancy and Sensitization Potential of Glyoxylic Acid AN - 20887860; 8403980 AB - Glyoxylic acid, a small dicarboxylic acid, has been detected at measurable levels in the atmosphere and is suspected to be present in indoor air environments. It is generated through the ozonolysis of several high volume production compounds that are commonly found indoors. Glyoxylic acid was tested in a combined irritancy and local lymph node assay (LLNA). It tested positive in the LLNA with an EC3 value of 5.05%. Significant increases were observed in the B220+cell population in the draining lymph nodes. No changes were identified in the IgE+B220+ cell population in the draining lymph nodes or total serum IgE levels; this suggests that glyoxylic acid functions as a T-cell-mediated contact sensitizer. Exposure to volatile organic compounds (VOC), similar to glyoxylic acid, emitted from building materials, cleaning formulations or other consumer products, and /or indoor chemistry have been linked to adverse health effects. These results may provide an explanation for some of adverse health effects associated with indoor air exposure. JF - Journal of Immunotoxicology AU - Anderson, Stacey E AU - Ham, Jason E AU - Munson, Albert E AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 93 EP - 98 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 2 SN - 1547-691X, 1547-691X KW - Toxicology Abstracts; Immunology Abstracts KW - F 06910:Microorganisms & Parasites KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Irritancy+and+Sensitization+Potential+of+Glyoxylic+Acid&rft.au=Anderson%2C+Stacey+E%3BHam%2C+Jason+E%3BMunson%2C+Albert+E&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2008-04-01&rft.volume=5&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910802085681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15476910802085681 ER - TY - JOUR T1 - Fully automatic, retrospective enhancement of real-time acquired cardiac cine MR images using image-based navigators and respiratory motion-corrected averaging AN - 20857696; 8368752 AB - Real-time imaging may be clinically important in patients with congestive heart failure, arrhythmias, or in pediatric cases. However, real-time imaging typically has compromised spatial and temporal resolution compared with gated, segmented studies. To combine the best features of both types of imaging, a new method is proposed that uses parallel imaging to improve temporal resolution of real-time acquired images at the expense of signal-to-noise ratio (SNR), but then produces an SNR-enhanced cine by means of respiratory motion-corrected averaging of images acquired in real-time over multiple heartbeats while free-breathing. The retrospective processing based on image-based navigators and nonrigid image registration is fully automated. The proposed method was compared with conventional cine images in 21 subjects. The resultant image quality for the proposed method (3.9 - 0.44) was comparable to the conventional cine (4.2 - 0.99) on a 5-point scale (P = not significant [n.s.]). The conventional method exhibited degraded image quality in cases of arrhythmias whereas the proposed method had uniformly good quality. Motion-corrected averaging of real-time acquired cardiac images provides a means of attaining high-quality cine images with many of the benefits of real-time imaging, such as free-breathing acquisition and tolerance to arrhythmias. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Chefd'hotel, Christophe AU - Lorenz, Christine H AU - Mancini, Christine AU - Arai, Andrew E AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 771 EP - 778 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Arrhythmia KW - Pediatrics KW - N.M.R. KW - congestive heart failure KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Fully+automatic%2C+retrospective+enhancement+of+real-time+acquired+cardiac+cine+MR+images+using+image-based+navigators+and+respiratory+motion-corrected+averaging&rft.au=Kellman%2C+Peter%3BChefd%27hotel%2C+Christophe%3BLorenz%2C+Christine+H%3BMancini%2C+Christine%3BArai%2C+Andrew+E%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Arrhythmia; Pediatrics; N.M.R.; congestive heart failure DO - http://dx.doi.org/10.1002/mrm.21509 ER - TY - JOUR T1 - Modification of the Submerged Coil To Prevent Microbial Carryover Error in Thermal Death Studies AN - 20846666; 8189921 AB - A submerged coil unit generates death rate data for foodborne pathogens through precise computer-controlled sequential sampling rather than the usual manually timed, labor-intensive single sampling associated with other approaches. Our work with Yersinia pseudotuberculosis and Listeria monocytogenes Scott A using the submerged coil unit indicated non-log-linear death rates with large degrees of tailing. Varying degrees of cell adhesion to the surface of the exit port resulted in carryover that was likely the primary cause of these non-log-linear kinetics. This carryover also resulted in erroneously high measured levels of thermal resistance for both organisms. To address the carryover problem, modifications were made to the exit port of the submerged coil unit to ensure continuous and uniform heat treatment. These modifications resulted in a 2-fold decrease in measured D-values for L. monocytogenes Scott A and a 10-fold decrease in measured D- values for Y. pseudotuberculosis. D-values measured with the modified machine for L. monocytogenes Scott A were similar to those found in the literature. Slight tailing in survival curves persisted with the modified method, particularly for Y. pseudotuberculosis. These results indicate that kinetic data for microbial death rates obtained using an unmodified submerged coil unit must be viewed with suspicion in light of the significant potential for carryover. JF - Journal of Food Protection AU - Keller, Susanne E AU - Shazer, Arlette G AU - Fleischman, Gregory J AU - Chirtel, Stuart AU - Anderson, Nathan AU - Larkin, John AD - U.S. Food and Drug Administration Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 775 EP - 780 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 4 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Listeria monocytogenes KW - Mortality KW - Food KW - Yersinia pseudotuberculosis KW - Survival KW - Pathogens KW - Mine tailings KW - Cell adhesion KW - Kinetics KW - adhesion KW - Sampling KW - survival KW - Pseudotuberculosis KW - Heat treatments KW - A 01330:Food Microbiology KW - J 02490:Miscellaneous KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20846666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Modification+of+the+Submerged+Coil+To+Prevent+Microbial+Carryover+Error+in+Thermal+Death+Studies&rft.au=Keller%2C+Susanne+E%3BShazer%2C+Arlette+G%3BFleischman%2C+Gregory+J%3BChirtel%2C+Stuart%3BAnderson%2C+Nathan%3BLarkin%2C+John&rft.aulast=Keller&rft.aufirst=Susanne&rft.date=2008-04-01&rft.volume=71&rft.issue=4&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%29071%253C0775%3AMOTSCT%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Food; Kinetics; Survival; Pathogens; Sampling; Heat treatments; Pseudotuberculosis; Cell adhesion; Mortality; adhesion; survival; Mine tailings; Listeria monocytogenes; Yersinia pseudotuberculosis DO - http://dx.doi.org/10.1043/0362-028X(2008)071%3C0775:MOTSCT%3E2.3.CO;2 ER - TY - JOUR T1 - Evaluation of multiple strains of Enterobacter sakazakii using fatty acid profiles AN - 20838511; 7916669 AB - Fatty acid profiles are useful for identifying Gram-negative Enterobacter sakazakii strains within the family Enterobacteriaceae. The majority of cases of E. sakazakii infection have involved sepsis, meningitis, or enteritis, especially in neonates and infants. Gas chromatography with flame ionization detection (GC-FID) was utilized for the analysis of cellular fatty acid methyl esters (FAMEs). Thirty E. sakazakiistrains isolated from food and environmental sources were cultured for 24h on brain heart infusion (BHI) agar on three different days at 37°C. Whole cell FAMEs were obtained by saponification, methylation and extraction into hexane:methyl tert-butyl ether. The day to day variations for the 30 E. sakazakii strains for each fatty acid were determined. Gram-negative bacteria commonly contain combinations of straight-chain, unsaturated, hydroxyl, and cyclo fatty acids. Major fatty acids of E. sakazakii strains evaluated in this study were straight chain 12:0, 14:0, 16:0 and unsaturated 16:1, 18:1, and 17:0 omega cyclo 7-8. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by this rapid GC-FID method is highly reproducible and provides a sensitive procedure for identification of this organism. The fatty acid profile assay could be used to rapidly screen infant formula samples for E. sakazakii and reduce the time required for the current assay by up to 5days. JF - Food Chemistry AU - Hoffmann, Maria AU - Keys, Christine E AU - Song, Kwang-Young AU - Brown, Eric W AU - Fry, Frederick S AU - Whittaker, Paul AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA, paul.whittaker@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1623 EP - 1628 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 107 IS - 4 SN - 0308-8146, 0308-8146 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Gas chromatography KW - Fatty acids KW - Enterobacter sakazakii KW - Heart KW - Agar KW - Infant formulas KW - Enteritis KW - Brain KW - Infection KW - Meningitis KW - Sepsis KW - Food sources KW - Gram-negative bacteria KW - fatty acid methyl esters KW - Ethers KW - Neonates KW - Methylation KW - Ionization KW - Enterobacteriaceae KW - Infants KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20838511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Evaluation+of+multiple+strains+of+Enterobacter+sakazakii+using+fatty+acid+profiles&rft.au=Hoffmann%2C+Maria%3BKeys%2C+Christine+E%3BSong%2C+Kwang-Young%3BBrown%2C+Eric+W%3BFry%2C+Frederick+S%3BWhittaker%2C+Paul&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2008-04-01&rft.volume=107&rft.issue=4&rft.spage=1623&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2007.10.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Agar; Infant formulas; Enteritis; Brain; Infection; Meningitis; Sepsis; Gas chromatography; Gram-negative bacteria; Food sources; fatty acid methyl esters; Fatty acids; Neonates; Ethers; Ionization; Methylation; Infants; Enterobacter sakazakii; Enterobacteriaceae DO - http://dx.doi.org/10.1016/j.foodchem.2007.10.032 ER - TY - JOUR T1 - Extended-spectrum b-lactamase (ESBL)-producing enterobacteria: factors associated with infection in the community setting, Auckland, New Zealand AN - 20823943; 8337756 AB - We aimed to document the epidemiology of extended-spectrum b-lactamase (ESBL)-producing enterobacteria in the Auckland community and identify factors associated with infection using a case-control study design. ESBL-producing enterobacteria were isolated from 107 infected patients, for which demographic and clinical data were available for 98 cases (92%). Escherichia coli was the predominant organism (82%), with urine as the commonest source (97%). Compared with a control group infected with ESBL-negative enterobacteria, factors significantly associated with infection on univariate analysis were: living in a residential care home (RCH); recent admission to hospital 'M'; recent antibiotic use; older age (>75 years); presence of a urinary catheter; and a history of comorbid chronic obstructive pulmonary disease (COPD), cardiovascular disease, neurological disease or recurrent urinary tract infection. On multivariate analysis, residence in RCH and COPD remained significant associations. Pulsed-field gel electrophoresis typing of the ESBL-producing E. coli identified a common strain. We concluded that residence in RCH and a history of COPD are significant associations with ESBL-producing enterobacterial infection in the Auckland community. Several spatial clusters in RCHs and a common strain suggest point-source outbreaks. A substantial number of community cases did not live in an RCH nor had been recently hospitalised, suggesting the independent generation of ESBL-producing enterobacteria in the broader community. JF - Journal of Hospital Infection AU - Moor, C T AU - Roberts, S A AU - Simmons, G AU - Briggs, S AU - Morris, A J AU - Smith, J AU - Heffernan, H AD - Auckland Regional Public Health Service, Auckland, New Zealand, gregs@adhb.govt.nz Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 355 EP - 362 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. 6277 Sea Harbor Drive Orlando, FL 32887-4800 USA, [mailto:hhspcs@harcourt.com], [URL:http://www.wbsaunders.com] VL - 68 IS - 4 SN - 0195-6701, 0195-6701 KW - Microbiology Abstracts B: Bacteriology KW - Antimicrobial drug resistance KW - Beta-lactamases KW - Community-acquired infections KW - Risk factors KW - Neurological diseases KW - Antibiotics KW - Urinary tract KW - Chronic obstructive pulmonary disease KW - Demography KW - Typing KW - Epidemiology KW - Urine KW - Multivariate analysis KW - Chronic infection KW - Escherichia coli KW - Geriatrics KW - Catheters KW - Pulsed-field gel electrophoresis KW - Recurrent infection KW - Cardiovascular diseases KW - b-Lactamase KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hospital+Infection&rft.atitle=Extended-spectrum+b-lactamase+%28ESBL%29-producing+enterobacteria%3A+factors+associated+with+infection+in+the+community+setting%2C+Auckland%2C+New+Zealand&rft.au=Moor%2C+C+T%3BRoberts%2C+S+A%3BSimmons%2C+G%3BBriggs%2C+S%3BMorris%2C+A+J%3BSmith%2C+J%3BHeffernan%2C+H&rft.aulast=Moor&rft.aufirst=C&rft.date=2008-04-01&rft.volume=68&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hospital+Infection&rft.issn=01956701&rft_id=info:doi/10.1016%2Fj.jhin.2008.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurological diseases; Antibiotics; Urinary tract; Chronic obstructive pulmonary disease; Demography; Typing; Epidemiology; Multivariate analysis; Urine; Chronic infection; Pulsed-field gel electrophoresis; Catheters; Geriatrics; Recurrent infection; b-Lactamase; Cardiovascular diseases; Hospitals; Escherichia coli DO - http://dx.doi.org/10.1016/j.jhin.2008.02.003 ER - TY - JOUR T1 - A Multilevel Analysis of State and Regional Disparities in Childhood and Adolescent Obesity in the United States AN - 20812823; 8156431 AB - This study examines state- and regional disparities in obesity prevalence among 46,707 US children and adolescents aged 10-17 years before and after adjusting for individual socioeconomic and behavioral characteristics and area deprivation measures. The 2003 National Survey of Children's Health was used to calculate obesity prevalence in nine geographic regions and in the 50 states and the District of Columbia (DC). Logistic regression was used to estimate odds of obesity and adjusted prevalence. OLS regression was used to determine the amount of variance explained by income inequality, poverty, and violent crime rates. The prevalence of childhood obesity varied substantially across geographic areas, with the Southcentral regions of the US having the highest prevalence ( greater than or equal to 18%) and the Mountain region the lowest prevalence (11.4%). Children in West Virginia, Kentucky, Texas, Tennessee, and North Carolina (adjusted prevalence > 18.3%) had over twice the odds of being obese than their Utah counterparts (adjusted prevalence = 10.4%). Geographic disparities in obesity were similar for male and female children. Individual characteristics such as race/ethnicity, household socioeconomic status, neighborhood social capital, television viewing, recreational computer use, and physical activity accounted for 55% of the state and 25% of the regional disparities in obesity. Area poverty rates accounted for an additional 18% of the state variance in adjusted obesity prevalence. Although individual and area level socioeconomic factors are important predictors, substantial geographic disparities in childhood and adolescent obesity remain. Prevention efforts targeting individual risk factors as well as contextual social and environmental factors may reduce geographic disparities in childhood and adolescent obesity. JF - Journal of Community Health AU - Singh, Gopal K AU - Kogan, Michael D AU - van Dyck, Peter C AD - Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 90 EP - 102 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 2 SN - 0094-5145, 0094-5145 KW - Physical Education Index KW - Obesity KW - Socioeconomic factors KW - Preventive health KW - Community health KW - Analysis KW - Adolescence KW - Television KW - Exercise KW - Children KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20812823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=A+Multilevel+Analysis+of+State+and+Regional+Disparities+in+Childhood+and+Adolescent+Obesity+in+the+United+States&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3Bvan+Dyck%2C+Peter+C&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-04-01&rft.volume=33&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-007-9071-7 LA - English DB - Physical Education Index N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Obesity; Adolescence; Children; Socioeconomic factors; Preventive health; Television; Exercise; Analysis; Community health DO - http://dx.doi.org/10.1007/s10900-007-9071-7 ER - TY - JOUR T1 - Nocardia wallacei sp. nov. and Nocardia blacklockiae sp. nov., Human Pathogens and Members of the "Nocardia transvalensis Complex" AN - 20668881; 8200467 AB - Nocardia isolates that share the property of in vitro amikacin resistance are grouped together by some authors in the Nocardia transvalensis complex. Our examination of 13 isolates that are amikacin resistant has revealed the existence of three distinct species. Sequence analysis of the 16S rRNA, 65-kDa heat shock protein, and secA1 genes, coupled with DNA-DNA hybridization, indicated that "N. asteroides drug pattern IV," "N. transvalensis new taxon 1," and N. transvalensis sensu stricto should each be considered a distinct species. The phenotypic and molecular characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N. blacklockiae (N. transvalensis new taxon 1) are presented and compared with those of N. transvalensis sensu stricto. The relative genetic diversity of isolates best placed with the species N. blacklockiae is also discussed. Case studies demonstrating the pathogenicity of N. wallacei and N. blacklockiae are presented. The type strain of N. wallacei is ATCC 49873 (DSM 45136), and that of N. blacklockiae is ATCC 700035 (DSM 45135). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Brown, June M AU - Steigerwalt, Arnold G AU - Brown-Elliott, Barbara A AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland. Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia. University of Texas Health Center, Department of Microbiology, Tyler, Texas Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1178 EP - 1184 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Nocardia transvalensis KW - Heat shock proteins KW - Amikacin KW - Pathogenicity KW - Genetic diversity KW - Pathogens KW - rRNA 16S KW - Drugs KW - New species KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Nocardia+wallacei+sp.+nov.+and+Nocardia+blacklockiae+sp.+nov.%2C+Human+Pathogens+and+Members+of+the+%22Nocardia+transvalensis+Complex%22&rft.au=Conville%2C+Patricia+S%3BBrown%2C+June+M%3BSteigerwalt%2C+Arnold+G%3BBrown-Elliott%2C+Barbara+A%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2008-04-01&rft.volume=46&rft.issue=4&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; Pathogenicity; Amikacin; Genetic diversity; Pathogens; Drugs; rRNA 16S; New species; Nocardia transvalensis ER - TY - JOUR T1 - Utility of polyclonal antibodies targeted toward unique tryptic peptides in the proteomic analysis of cytochrome P450 isozymes AN - 20589418; 8103602 AB - P450s are key enzymes responsible for biotransformation of numerous endogenous and exogenous compounds and are located in almost every tissue. This superfamily is the largest group of enzymes (>6000) that share a high degree of similarity in protein sequence. The human genome contains 57 CYP genes and 58 pseudogenes. A major gap exists in our knowledge about differences in CYP expression on a protein level. DNA and mRNA information are not sufficient because transcription and particularly translation events are not necessarily correlated with levels of expressed proteins. The data reported in this study complete the framework of an integrated proteomic method for the simultaneous qualitative and quantitative analysis of CYP isozyme composition using MALDI-TOF-MS and immunochemistry that has been developed in our laboratory over the last several years (Alterman et al., 2005a,b) and is based on the fact that each P450 isozyme possesses unique tryptic peptide(s) (UTP) that could be used for differential analysis of human CYP expression. Here we demonstrate that three different immunochemical techniques (ELISA, Western blot, and peptide affinity enrichment on magnetic beads with attached antibodies) have potential to be incorporated in an integrated proteomic method combining mass spectrometry and immunochemistry. Fundamentally, this approach is based on the measurement of the same chemical entity (isozyme-specific UTP) in the tryptic digest by two orthogonal analytical techniques, mass spectrometry and immunochemistry. The application of this approach is illustrated with two human CYP isozymes - CYP1A2 and CYP2E1. JF - Toxicology In Vitro AU - Kornilayev, BA AU - Alterman, MA AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA 8800 Rockville Pike, Building 29A, Room 2D12, HFM-735, Bethesda, MD 20892, United States, Michail.Alterman@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 779 EP - 787 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - Genomes KW - Translation KW - Pseudogenes KW - Western blotting KW - Enzyme-linked immunosorbent assay KW - CYP1A2 protein KW - Data processing KW - biotransformation KW - Enzymes KW - Transcription KW - Mass spectroscopy KW - Antibodies KW - Isoenzymes KW - DNA KW - Tryptic peptides KW - Cytochrome P450 KW - proteomics KW - Immunochemistry KW - Amino acid sequence KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20589418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Utility+of+polyclonal+antibodies+targeted+toward+unique+tryptic+peptides+in+the+proteomic+analysis+of+cytochrome+P450+isozymes&rft.au=Kornilayev%2C+BA%3BAlterman%2C+MA&rft.aulast=Kornilayev&rft.aufirst=BA&rft.date=2008-04-01&rft.volume=22&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2007.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Western blotting; Pseudogenes; Translation; Enzyme-linked immunosorbent assay; Data processing; CYP1A2 protein; biotransformation; Transcription; Enzymes; Mass spectroscopy; Antibodies; DNA; Isoenzymes; Tryptic peptides; proteomics; Cytochrome P450; Immunochemistry; Amino acid sequence DO - http://dx.doi.org/10.1016/j.tiv.2007.12.001 ER - TY - JOUR T1 - O Antigen Protects Bordetella parapertussis from Complement AN - 20542887; 8086180 AB - Bordetella pertussis, a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough, Bordetella parapertussis, does not. Interestingly, B. parapertussis, but not B. pertussis, produces an O antigen, a factor shown in other models to confer serum resistance. Using a murine model of infection, we determined that O antigen contributes to the ability of B. parapertussis to colonize the respiratory tract during the first week of infection, but not thereafter. Interestingly, an O antigen-deficient strain of B. parapertussis was not defective in colonizing mice lacking the complement cascade. O antigen prevented both complement component C3 deposition on the surface and complement-mediated killing of B. parapertussis. In addition, O antigen was required for B. parapertussis to systemically spread in complement-sufficient mice, but not complement-deficient mice. These data indicate that O antigen enables B. parapertussis to efficiently colonize the lower respiratory tract by protecting against complement-mediated control and clearance. JF - Infection and Immunity AU - Goebel, Elizabeth M AU - Wolfe, Daniel N AU - Elder, Kelly AU - Stibitz, Scott AU - Harvill, Eric T AD - Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802. Graduate Program in Immunology and Infectious Diseases. Graduate Program in Pathobiology. Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, Maryland 20892 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1774 EP - 1780 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 4 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Bordetella pertussis KW - Complement KW - Bordetella parapertussis KW - Animal models KW - O antigen KW - Complement component C3 KW - Pathogens KW - Infection KW - Respiratory tract KW - Models KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=O+Antigen+Protects+Bordetella+parapertussis+from+Complement&rft.au=Goebel%2C+Elizabeth+M%3BWolfe%2C+Daniel+N%3BElder%2C+Kelly%3BStibitz%2C+Scott%3BHarvill%2C+Eric+T&rft.aulast=Goebel&rft.aufirst=Elizabeth&rft.date=2008-04-01&rft.volume=76&rft.issue=4&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Complement; Animal models; O antigen; Complement component C3; Pathogens; Infection; Models; Respiratory tract; Bordetella pertussis; Bordetella parapertussis ER - TY - JOUR T1 - Aflatoxins contamination in spices and processed spice products commercialized in Korea AN - 20468304; 7916626 AB - A survey for total aflatoxins (aflatoxins B1, B2, G1, and G2) was conducted on 88 spices and processed spice products commercialized in Korea. The presence of aflatoxins was determined by high-performance liquid chromatography (HPLC) with fluorescence detector using immunoaffinity column clean-up. Total aflatoxins (AFs) are detected in 12 samples (13.6% of incidence) including seven red pepper powder, two red pepper pastes (Kochujang), two curry and one ginger product. The contamination levels are 0.08-4.45 is a subset of g/kg as aflatoxin B1 and 0.08-4.66 is a subset of g/kg as AFs. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis on contaminated samples was conducted for the confirmation of detected aflatoxins. The 12 samples which showed aflatoxins by HPLC/FLD were confirmed as aflatoxins by LC-MS/MS. JF - Food Chemistry AU - Cho, Sung-Hye AU - Lee, Chang-Hee AU - Jang, Mi-Ran AU - Son, Young-Wook AU - Lee, Sang-Mok AU - Choi, In-Sun AU - Kim, So-Hee AU - Kim, Dai-Byung AD - Busan Regional Agency, Korea Food and Drug Administration, Busan 608-829, Republic of Korea, chang65@hanmail.net Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1283 EP - 1288 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 107 IS - 3 SN - 0308-8146, 0308-8146 KW - Toxicology Abstracts KW - Aflatoxins KW - Spices KW - Immunoaffinity column KW - HPLC-FLD KW - LC-MS/MS KW - High-performance liquid chromatography KW - Aflatoxin B1 KW - Powder KW - Fluorescence KW - Food contamination KW - Mass spectroscopy KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Aflatoxins+contamination+in+spices+and+processed+spice+products+commercialized+in+Korea&rft.au=Cho%2C+Sung-Hye%3BLee%2C+Chang-Hee%3BJang%2C+Mi-Ran%3BSon%2C+Young-Wook%3BLee%2C+Sang-Mok%3BChoi%2C+In-Sun%3BKim%2C+So-Hee%3BKim%2C+Dai-Byung&rft.aulast=Cho&rft.aufirst=Sung-Hye&rft.date=2008-04-01&rft.volume=107&rft.issue=3&rft.spage=1283&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2007.08.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Aflatoxin B1; High-performance liquid chromatography; Powder; Fluorescence; Spices; Aflatoxins; Food contamination; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.foodchem.2007.08.049 ER - TY - JOUR T1 - Nutrigenomics research for personalized nutrition and medicine AN - 20269717; 8853264 AB - Current nutritional and genetic epidemiological methods yield 'risk factors' on the basis of population studies. Risk factors, however, are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. These measures are often assumed to apply to individuals who are likely to differ in genetic make-up, lifestyle, and dietary patterns than to the individuals in the study population. Developing individual risk factors in light of the genetic diversity of human populations, the complexity of foods, culture and lifestyle, and the variety of metabolic processes that lead to health or disease is a significant challenge for personalizing dietary advice for healthy or individuals with chronic disease. JF - Current Opinion in Biotechnology AU - Kaput, Jim AD - Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States, James.Kaput@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 110 EP - 120 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 2 SN - 0958-1669, 0958-1669 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Statistics KW - Risk factors KW - Reviews KW - Food KW - Population studies KW - Genetic diversity KW - Nutrition KW - W 30910:Imaging KW - G 07750:Ecological & Population Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20269717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Nutrigenomics+research+for+personalized+nutrition+and+medicine&rft.au=Kaput%2C+Jim&rft.aulast=Kaput&rft.aufirst=Jim&rft.date=2008-04-01&rft.volume=19&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2008.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Food; Reviews; Risk factors; Genetic diversity; Population studies; Nutrition DO - http://dx.doi.org/10.1016/j.copbio.2008.02.005 ER - TY - JOUR T1 - Investigational new drugs submitted to the Food and Drug Administration that are placed on clinical hold: the experience of the Office of Cellular, Tissue and Gene Therapy AN - 20133764; 10252889 AB - Background Cell and gene therapies are medical products regulated by the U.S. Food and Drug Administration (FDA) within its Center of Biologics Evaluation and Research (CBER) in the Office of Cellular, Tissue, and Gene Therapy (OCTGT). Clinical research using cell and gene therapies in the United States must be conducted under an Investigational New Drug (IND) application. After an initial, 30-day review FDA either places an IND on clinical hold or allows the IND to proceed. Methods We reviewed letters sent by OCTGT to IND sponsors that were placed on clinical hold. We categorized each deficiency and determined its frequency. Results We found that similar deficiencies existed across IND applications and we tabulated the most common deficiencies. Discussion We discussed the deficiencies and the resources that can help individuals avoid those deficiencies. We believe that awareness of the common deficiencies along with the applicable resources can reduce the frequency of clinical holds and allow clinical studies to proceed without delay. We also believe that this information will guide the FDA as to how to facilitate development of safe and effective cell and gene therapies. JF - Cytotherapy AU - Wonnacott, K AU - Lavoie, D AU - Fiorentino, R AU - McIntyre, M AU - Huang, Y AU - Hirschfeld, S AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 312 EP - 316 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 10 IS - 3 SN - 1465-3249, 1465-3249 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Medical equipment KW - Reviews KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20133764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytotherapy&rft.atitle=Investigational+new+drugs+submitted+to+the+Food+and+Drug+Administration+that+are+placed+on+clinical+hold%3A+the+experience+of+the+Office+of+Cellular%2C+Tissue+and+Gene+Therapy&rft.au=Wonnacott%2C+K%3BLavoie%2C+D%3BFiorentino%2C+R%3BMcIntyre%2C+M%3BHuang%2C+Y%3BHirschfeld%2C+S&rft.aulast=Wonnacott&rft.aufirst=K&rft.date=2008-04-01&rft.volume=10&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Cytotherapy&rft.issn=14653249&rft_id=info:doi/10.1080%2F14653240801910905 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Gene therapy; Medical equipment; Reviews DO - http://dx.doi.org/10.1080/14653240801910905 ER - TY - JOUR T1 - Digital-analog hybrid control model for eukaryotic heat shock response illustrating the dynamics of heat shock protein 70 on exposure to thermal stress AN - 19920306; 8688846 AB - We are introducing in this paper a digital-analog hybrid model approach for the study of a complete gene regulatory network; the heat shock response (HSR) network of eukaryotes. HSR is a crucial and widely studied cellular phenomenon occurring due to various stresses on the cell, and is characterised by the induction of heat shock genes resulting in the production of heat shock proteins (HSPs) which restores cellular homeostasis by maintaining protein integrity. We are proposing a model which incorporates simple digital and analog components which mimic the functioning of biological molecules involved in HSR and model their dynamics and behaviour. The simulation result of the circuit for the production of HSP70 has been found to be consistent with published experimental results. The qualitative behaviour of the HSR is expressed through a truth table. Through this novel approach, the authors have tried to develop a level of understanding of the interactions of the parts of the HSR system and of this system as a whole. JF - Computer Methods and Programs in Biomedicine AU - Dwivedi, Anjana AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar AD - Department of Electrical and Electronics Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India, dwivedi.anjana@gmail.com Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 17 EP - 24 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 1 SN - 0169-2607, 0169-2607 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Digital-analog hybrid model KW - Gene regulatory network KW - Heat shock response KW - Heat shock protein 70 KW - Molecular modelling KW - Heat shock proteins KW - Hsp70 protein KW - Hybrids KW - Stress KW - Circuits KW - Homeostasis KW - Computer applications KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19920306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Digital-analog+hybrid+control+model+for+eukaryotic+heat+shock+response+illustrating+the+dynamics+of+heat+shock+protein+70+on+exposure+to+thermal+stress&rft.au=Dwivedi%2C+Anjana%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Dwivedi&rft.aufirst=Anjana&rft.date=2008-04-01&rft.volume=90&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2007.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Heat shock proteins; Hsp70 protein; Hybrids; Stress; Circuits; Homeostasis; Computer applications DO - http://dx.doi.org/10.1016/j.cmpb.2007.11.008 ER - TY - JOUR T1 - Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts AN - 19806011; 8833218 AB - We have previously reported that metabolism of a series of pyrrolizidine alkaloids in vitro and in vivo generated a set of (+/-)6, 7-dihydro-7-hydroxy-l-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. It has also been shown that the levels of the DHP-derived DNA adduct formation correlated closely with the tumorigenic potencies of the mice fed with different doses of riddelliine. Retronecine is the necine base and the structurally smallest chemical of the retroneeine-type pyrrolizidine alkaloids. Although it has been reported that microsomal metabolism of retronecine generated DHP as a metabolite, it was yet not known whether metabolism of retronecine in vivo could generate DHP-derived DNA adducts and if formed, whether or not the levels of DNA adducts were comparable with those formed from the other tumorigenic retronecine-type pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline. In this investigation, the in-vitro and in-vivo metabolic activation of retronecine was studied. Rat liver microsomal metabolism of retronecine in the presence of calf thymus DNA resulted in the formation of a set of DHP-DNA adducts. The metabolism of retronecine N-oxide under similar conditions also formed the similar set of DHP-DNA adducts. The level of DNA adducts from retronecine was enhanced when metabolism by liver microsomes from phenobarbital (PB)-induced rats were used. The DHP-DNA adducts were also found in the liver DNA of female F344 rats treated with retronecine or retronecine N-oxide. The highest level of the total DHP-DNA adducts was found in liver DNA from the rats treated with dehydroretronecine (DHR). The order of the levels of DNA adducts in the liver DNA samples from rats treated with various pyrrolizidine alkaloids was: DHR > riddelliine > riddelliine N-oxide >> retronecine > retronecine N-oxide. The results indicate that 1) retronecine can be metabolized to form DHP by rat liver microsomal enzymes and interacts with DNA to produce DHP-DNA adducts and 2) retronecine N-oxide undergoes the biotransformation to the parent compound, retronecine. The results from this and our previous findings strongly suggest that formation of DHP-DNA adducts may be a potential biomarker for pyrrolizidine alkaloid carcinogenesis. JF - Toxicology and Industrial Health AU - Yan, J AU - Xia, Q AU - Chou, M W AU - Fu, P P AD - National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA, peter.fu@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 181 EP - 188 VL - 24 IS - 3 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Calf thymus KW - DNA adducts KW - Microsomes KW - Phenobarbital KW - biotransformation KW - N-Oxides KW - Enzymes KW - retrorsine KW - biomarkers KW - pyrrolizidine alkaloids KW - Carcinogenesis KW - Monocrotaline KW - Liver KW - Metabolic activation KW - Dehydroretronecine KW - N 14820:DNA Metabolism & Structure KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Metabolic+activation+of+retronecine+and+retronecine+N-oxide+-+formation+of+DHP-derived+DNA+adducts&rft.au=Yan%2C+J%3BXia%2C+Q%3BChou%2C+M+W%3BFu%2C+P+P&rft.aulast=Yan&rft.aufirst=J&rft.date=2008-04-01&rft.volume=24&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708093727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Calf thymus; DNA adducts; Phenobarbital; Microsomes; N-Oxides; biotransformation; Enzymes; retrorsine; biomarkers; pyrrolizidine alkaloids; Carcinogenesis; Liver; Monocrotaline; Metabolic activation; Dehydroretronecine DO - http://dx.doi.org/10.1177/0748233708093727 ER - TY - JOUR T1 - Detection of naturally occurring enteroviruses in waters using direct RT-PCR and integrated cell culture-RT-PCR AN - 19682434; 8245652 AB - Viruses detected by rapid molecular assays are not always infectious. In this study we compared enterovirus levels in natural waters using culture and reverse transcription-polymerase chain reaction (RT-PCR) techniques to determine whether molecular units of naturally occurring enteroviruses can be utilized to predict viral infectivity. Viruses were concentrated from 12 river water and effluent samples using 1MDS filter-filtration and beef extract-elution. An integrated cell culture-RT-PCR (ICC-RT-PCR) was applied to the concentrates; and these waters contained up to 1.9MPN of culturable (on BGM cells) viruses per litre (0.57MPN /300ml). Sample concentrates were also subjected to a direct 'molecular' approach using solvent-extraction, PEG-precipitation, and RNA-extraction before RT-PCR detection. The detection sensitivity of the direct RT-PCR was equivalent to 0.46 estimated (culturable) MPN/reaction, per 300ml water. Two-thirds of the samples demonstrated consistent presence or absence of viruses by ICC-RT-PCR and direct RT-PCR. The direct RT-PCR approach resulted in over-estimation of naturally occurring infectious viruses as high as 91-fold in waters. Increased RT-PCR units may not reflect higher levels of culturable viruses in natural waters. The differences in virus levels detected by molecular and culture assays could be attributed to factors of volume of sample analyzed, different concentration schemes utilized that may affect the presence of residual inhibitors, and different stability exhibited by enterovirus strains/groups. JF - Journal of Virological Methods AU - Shieh, Y C AU - Wong, C I AU - Krantz, JA AU - Hsu, F C AD - Dauphin Island, AL 36528, USA, carol.shieh@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 184 EP - 189 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 149 IS - 1 SN - 0166-0934, 0166-0934 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Rivers KW - Infectivity KW - Enterovirus KW - Beef KW - Polymerase chain reaction KW - Cell culture KW - Effluents KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19682434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Detection+of+naturally+occurring+enteroviruses+in+waters+using+direct+RT-PCR+and+integrated+cell+culture-RT-PCR&rft.au=Shieh%2C+Y+C%3BWong%2C+C+I%3BKrantz%2C+JA%3BHsu%2C+F+C&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2008-04-01&rft.volume=149&rft.issue=1&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2007.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rivers; Infectivity; Beef; Polymerase chain reaction; Cell culture; Effluents; Enterovirus DO - http://dx.doi.org/10.1016/j.jviromet.2007.12.013 ER - TY - JOUR T1 - In Vitro Model of Colonization Resistance by the Enteric Microbiota: Effects of Antimicrobial Agents Used in Food-Producing Animals AN - 19528728; 8083436 AB - A bioassay was developed to measure the minimum concentration of an antimicrobial drug that disrupts the colonization resistance mediated by model human intestinal microbiota against Salmonella invasion of Caco-2 intestinal cells. The bioassay was used to measure the minimum disruptive concentrations (MDCs) of drugs used in animal agriculture. The MDCs varied from 0.125 mu g/ml for some broad-spectrum antimicrobial drugs (e.g., streptomycin) to 16 mu g/ml for drugs with limited spectra of antimicrobial activity (e.g., lincomycin). The acceptable daily intake (ADI) residue concentration calculated on the basis of the MDCs were higher for erythromycin, lincomycin, and tylosin than the ADI residue concentrations calculated on the basis of the MICs. The MDC-based ADI values for apramycin, bacitracin, neomycin, novobiocin, penicillin G, streptomycin, tetracycline, and vancomycin were lower than the reported MIC-based ADI values. The effects of antimicrobial drugs at their MDCs on the bacterial composition of the microbiota were observed by denaturing gradient gel electrophoresis of 16S rRNA sequences amplified by PCR. Changes in the population composition of the model colonization resistance microbiota occurred simultaneously with reduced colonization resistance. The results of this study suggest that direct assessment of the effects of antimicrobial drugs on colonization resistance in an in vitro model can be useful in determining ADI values. JF - Antimicrobial Agents & Chemotherapy AU - Wagner, RDoug AU - Johnson, Shemedia J AU - Cerniglia, Carl E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1230 EP - 1237 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Agriculture KW - Antimicrobial activity KW - Drug resistance KW - Food KW - Streptomycin KW - Bacitracin KW - Tetracyclines KW - Colonization KW - Polymerase chain reaction KW - Vancomycin KW - Neomycin KW - Drugs KW - Novobiocin KW - Lincomycin KW - Apramycin KW - Erythromycin KW - Minimum inhibitory concentration KW - Penicillin KW - Gel electrophoresis KW - Antimicrobial agents KW - Intestinal microflora KW - Intestine KW - Tylosin KW - Salmonella KW - rRNA 16S KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19528728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Model+of+Colonization+Resistance+by+the+Enteric+Microbiota%3A+Effects+of+Antimicrobial+Agents+Used+in+Food-Producing+Animals&rft.au=Wagner%2C+RDoug%3BJohnson%2C+Shemedia+J%3BCerniglia%2C+Carl+E&rft.aulast=Wagner&rft.aufirst=RDoug&rft.date=2008-04-01&rft.volume=52&rft.issue=4&rft.spage=1230&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Agriculture; Antimicrobial activity; Food; Drug resistance; Novobiocin; Lincomycin; Bacitracin; Streptomycin; Apramycin; Tetracyclines; Erythromycin; Minimum inhibitory concentration; Gel electrophoresis; Penicillin; Antimicrobial agents; Intestinal microflora; Colonization; Intestine; Vancomycin; Polymerase chain reaction; Neomycin; Tylosin; rRNA 16S; Drugs; Salmonella ER - TY - JOUR T1 - Bombesin marine toxin conjugates inhibit the growth of lung cancer cells AN - 19512406; 8838256 AB - Hemiasterlin (Hem) and dolastatin (Dol) are marine natural products which are cytotoxic for cancer cells. Hem, a tripeptide, and Dol, a hexapeptide, were conjugated with linkers (L) to the universal BB agonist DPhe-Gln-Trp- Ala-Val- beta Ala-His-Phe-Nle-NH sub(2)(BA1) and the effects of the Hem-BB and Dol- BB conjugates investigated on NCI-H1299 lung cancer cells. Hem-LA-BA1 and Hem-LB-BA1 inhibited specific ( super(125)I-Tyr super(4))BB binding to NCI-H1299 cells, which have BB sub(2) receptors (R), with IC sub(50) values of 15 and 25 nM, respectively. Addition of Hem-LA-BA1 and Hem-LB-BA1 to Fura-2 AM loaded cells containing BB sub(2)R, caused elevated cytosolic Ca super(2+). In a growth assay, Hem-LA-BA1 and Hem-LB-BA1 inhibited the proliferation of NCI-H1299 cells. Dol-succinamide (Dols)-LD-BA1 and Dols-LE-BA1 bound with high affinity to NCI-H1299 cells and elevated cytosolic Ca super(2+), but did not inhibit the proliferation of NCI-H1299 cells. Also, Hem-LA-BA1 inhibited super(125)I-DTyr- Gln-Trp-Ala-Val- beta Ala-His-Phe-Nle-NH sub(2) (BA2) binding to Balb/3T3 cells transfected with BB sub(1)R or BB sub(2)R as well as with BRS-3 with IC sub(50) values of 130, 8, and 540 nM, respectively. These results show that Hem-BB conjugates are cytotoxic for cancer cells containing BB sub(2)R. JF - Life Sciences AU - Moody, Terry W AU - Pradhan, Tapas AU - Mantey, Samuel A AU - Jensen, Robert T AU - Dyba, Marcin AU - Moody, Deborah AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Department of Health and Human Services, NCI Office of the Director, CCR, Bethesda, MD 20892 USA, moodyt@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 855 EP - 861 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 82 IS - 15-16 SN - 0024-3205, 0024-3205 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; ASFA Marine Biotechnology Abstracts KW - Bombesin KW - Dolastatin KW - Hemiasterlin KW - Lung cancer KW - Cytotoxicity KW - Calcium KW - Fura-2 KW - natural products KW - Cell proliferation KW - Toxins KW - T 2000:Cellular Calcium KW - Q4 27700:Molecular Techniques KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+Sciences&rft.atitle=Bombesin+marine+toxin+conjugates+inhibit+the+growth+of+lung+cancer+cells&rft.au=Moody%2C+Terry+W%3BPradhan%2C+Tapas%3BMantey%2C+Samuel+A%3BJensen%2C+Robert+T%3BDyba%2C+Marcin%3BMoody%2C+Deborah%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2008-04-01&rft.volume=82&rft.issue=15-16&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Life+Sciences&rft.issn=00243205&rft_id=info:doi/10.1016%2Fj.lfs.2008.01.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Calcium; Bombesin; Fura-2; natural products; Cell proliferation; Toxins; Lung cancer DO - http://dx.doi.org/10.1016/j.lfs.2008.01.019 ER - TY - JOUR T1 - Population Structure of Invasive and Colonizing Strains of Streptococcus agalactiae from Neonates of Six U.S. Academic Centers from 1995 to 1999 AN - 19480676; 8200483 AB - The purpose of this study was to describe the population structure of group B streptococci (GBS) isolated from infected and colonized neonates during a prospective active-surveillance study of early-onset disease in six centers in the United States from July 1995 to June 1999 and to examine its relationship to bovine strains of GBS. The phylogenetic lineage of each GBS isolate was determined by multilocus sequence typing, and isolates were clustered into clonal complexes (CCs) using the eBURST software program. A total of 899 neonatal GBS isolates were studied, of which 129 were associated with invasive disease. Serotype Ia, Ib, and V isolates were highly clonal, with 92% to 96% of serotype Ia, Ib, and V isolates being confined to single clonal clusters. In contrast, serotype II and III isolates were each comprised of two major clones, with 39% of serotype II and 41% of serotype III isolates in CC 17 and 41% of serotype II and 54% of serotype III isolates in CC 19. Further analysis demonstrates that the CC 17 serotype II and III GBS are closely related to a previously described "ancestral" lineage of bovine GBS. While 120 (93%) of invasive GBS were confined to the same lineages that colonized neonates, 9 (7%) of the invasive GBS isolates were from rare lineages that comprised only 2.7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates. JF - Journal of Clinical Microbiology AU - Bohnsack, John F AU - Whiting, April AU - Gottschalk, Marcelo AU - Dunn, Diane Marie AU - Weiss, Robert AU - Azimi, Parvin H AU - Philips, Joseph BIII AU - Weisman, Leonard E AU - Rhoads, George G AU - Lin, Feng-Ying C AD - Department of Pediatrics. Genome Center, University of Utah Health Sciences Center, Salt Lake City, Utah. Faculte de Medicine Veterinaire, Universite de Montreal, Saint-Hyacinthe, Quebec, Canada. Department of Infectious Diseases, Children's Hospital Medical Center of Northern California, Oakland, California. University of Alabama at Birmingham, Birmingham, Alabama. Baylor College of Medicine, Houston, Texas. University of Dentistry and Medicine of New Jersey, Piscataway, New Jersey. National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1285 EP - 1291 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Computer programs KW - software KW - Age KW - Serotypes KW - Guillain-Barre syndrome KW - Streptococcus agalactiae KW - Population structure KW - Neonates KW - multilocus sequence typing KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19480676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Population+Structure+of+Invasive+and+Colonizing+Strains+of+Streptococcus+agalactiae+from+Neonates+of+Six+U.S.+Academic+Centers+from+1995+to+1999&rft.au=Bohnsack%2C+John+F%3BWhiting%2C+April%3BGottschalk%2C+Marcelo%3BDunn%2C+Diane+Marie%3BWeiss%2C+Robert%3BAzimi%2C+Parvin+H%3BPhilips%2C+Joseph+BIII%3BWeisman%2C+Leonard+E%3BRhoads%2C+George+G%3BLin%2C+Feng-Ying+C&rft.aulast=Bohnsack&rft.aufirst=John&rft.date=2008-04-01&rft.volume=46&rft.issue=4&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Computer programs; Age; software; Serotypes; Guillain-Barre syndrome; Population structure; Neonates; multilocus sequence typing; Streptococcus agalactiae ER - TY - JOUR T1 - Semicarbazide formation in flour and bread. AN - 70414345; 18303820 AB - Azodicarbonamide, an approved food additive, is commonly used as a flour additive and dough conditioner in the United States and Canada. A number of researchers have clearly established a link between the use of azodicarbonamide and semicarbazide contamination in commercial bread products. However, all of these studies have primarily focused on the final baked product and have not extensively investigated the processing and conditions that affect the final semicarbazide levels. In this study, a previously developed method for measuring free semicarbazide in bread was applied to dough samples during the mixing and kneading process. Additionally, flour and bread samples were spiked with biurea or azodicarbonamide to help elucidate semicarbazide formation pathways. The results showed that semicarbazide was not formed as a byproduct of azodicarbonamide decomposition to biurea, which occurs upon the addition of water. Indeed, semicarbazide was not detected after room temperature or elevated temperature dough maturation, but only after baking. It was concluded that although azodicarbonamide is the initial starting material, semicarbazide formation in bread occurs through a stable intermediate, biurea. JF - Journal of agricultural and food chemistry AU - Noonan, Gregory O AU - Begley, Timothy H AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. gregory.noonan@fda.hhs.gov Y1 - 2008/03/26/ PY - 2008 DA - 2008 Mar 26 SP - 2064 EP - 2067 VL - 56 IS - 6 SN - 0021-8561, 0021-8561 KW - Azo Compounds KW - 0 KW - Biureas KW - Food Additives KW - Semicarbazides KW - 1,1-azobisformamide KW - 56Z28B9C8O KW - Index Medicus KW - Hot Temperature KW - Azo Compounds -- chemistry KW - Food Additives -- chemistry KW - Food Contamination -- analysis KW - Food Handling KW - Biureas -- chemistry KW - Flour -- analysis KW - Semicarbazides -- chemical synthesis KW - Semicarbazides -- analysis KW - Bread -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70414345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Semicarbazide+formation+in+flour+and+bread.&rft.au=Noonan%2C+Gregory+O%3BBegley%2C+Timothy+H%3BDiachenko%2C+Gregory+W&rft.aulast=Noonan&rft.aufirst=Gregory&rft.date=2008-03-26&rft.volume=56&rft.issue=6&rft.spage=2064&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf073198g LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf073198g ER - TY - JOUR T1 - Strategic paths for biomarker qualification AN - 20664736; 8185027 AB - Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end of discussions in the scientific literature as an indication that a biomarker has been accepted. An active approach to qualification requires development of a comprehensive process by which a consensus may be reached about the qualification of a biomarker. Active strategies for qualification include those associated with context-independent as well as context-dependent qualifications. JF - Toxicology AU - Goodsaid, F M AU - Frueh, F W AU - Mattes, W AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, FDA, United States, Federico.Goodsaid@fda.hhs.gov Y1 - 2008/03/20/ PY - 2008 DA - 2008 Mar 20 SP - 219 EP - 223 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 245 IS - 3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20664736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Strategic+paths+for+biomarker+qualification&rft.au=Goodsaid%2C+F+M%3BFrueh%2C+F+W%3BMattes%2C+W&rft.aulast=Goodsaid&rft.aufirst=F&rft.date=2008-03-20&rft.volume=245&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.tox.2007.12.023 ER - TY - CPAPER T1 - Zinc Diethyldithiocarbamate Allergenicity: Potential Haptenation Mechanisms. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859512; 4813185 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chipinda, I AU - Hettick, J M AU - Simoyi, R H AU - Siegel, P D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Zinc KW - Allergenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Zinc+Diethyldithiocarbamate+Allergenicity%3A+Potential+Haptenation+Mechanisms.&rft.au=Chipinda%2C+I%3BHettick%2C+J+M%3BSimoyi%2C+R+H%3BSiegel%2C+P+D&rft.aulast=Chipinda&rft.aufirst=I&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Local Antibody Class Switching in the Nasal Mucosa of Mice with TDI Rhinitis. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859414; 4813181 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Johnson, V J AU - Fluharty, K AU - Reynolds, J S AU - Luster, M I AU - Yucesoy, B Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Rhinitis KW - Antibodies KW - Class switching KW - Mucosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Local+Antibody+Class+Switching+in+the+Nasal+Mucosa+of+Mice+with+TDI+Rhinitis.&rft.au=Johnson%2C+V+J%3BFluharty%2C+K%3BReynolds%2C+J+S%3BLuster%2C+M+I%3BYucesoy%2C+B&rft.aulast=Johnson&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Labeled Single Walled Carbon Nanotubes to Study Acute Translocation from the Lungs. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859347; 4813171 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Mercer, R R AU - Scabilloni, J F AU - Wang, L AU - Battelli, L A AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Translocation KW - Lung KW - Nanotechnology KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+Labeled+Single+Walled+Carbon+Nanotubes+to+Study+Acute+Translocation+from+the+Lungs.&rft.au=Mercer%2C+R+R%3BScabilloni%2C+J+F%3BWang%2C+L%3BBattelli%2C+L+A%3BCastranova%2C+V&rft.aulast=Mercer&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of an Improved Strategy for the Derivation of Skin Notations T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859022; 4813078 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Dotson, G AU - Maier, A AU - Gadagbui, B AU - Geraci, C L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Development+of+an+Improved+Strategy+for+the+Derivation+of+Skin+Notations&rft.au=Dotson%2C+G%3BMaier%2C+A%3BGadagbui%2C+B%3BGeraci%2C+C+L&rft.aulast=Dotson&rft.aufirst=G&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumors Derived from Many Different Tissues may have Polyclonal Origin: Evidence and Implications. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858987; 4813246 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Parsons, B L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Tumors+Derived+from+Many+Different+Tissues+may+have+Polyclonal+Origin%3A+Evidence+and+Implications.&rft.au=Parsons%2C+B+L&rft.aulast=Parsons&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Assessment of Acrylamide in Food Contact Materials. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858885; 4813232 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Henry, S H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Risk assessment KW - Acrylamide KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Risk+Assessment+of+Acrylamide+in+Food+Contact+Materials.&rft.au=Henry%2C+S+H&rft.aulast=Henry&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defining Neuroinflammation: Lessons from MPTP- and Methamphetamine-Induced Neurotoxicity. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858802; 4813092 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - O'Callaghan, J P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Defining+Neuroinflammation%3A+Lessons+from+MPTP-+and+Methamphetamine-Induced+Neurotoxicity.&rft.au=O%27Callaghan%2C+J+P&rft.aulast=O%27Callaghan&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Year of Biomarker Qualification Submissions through the Pilot Process for Biomarker Qualification at the FDA. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858299; 4813338 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Goodsaid, F M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Bioindicators KW - FDA KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=A+Year+of+Biomarker+Qualification+Submissions+through+the+Pilot+Process+for+Biomarker+Qualification+at+the+FDA.&rft.au=Goodsaid%2C+F+M&rft.aulast=Goodsaid&rft.aufirst=F&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Endotoxin-induced Acute Kidney Injury in Rats. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858163; 4812976 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Brown, R P AU - Vaidya, V S AU - Beach, B C AU - Toal, M C AU - Loftin, S T AU - Zhang, J AU - Collings, F B AU - Bonventre, J V AU - Goering, P L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Kidneys KW - Injuries KW - Rats KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Detection+of+Endotoxin-induced+Acute+Kidney+Injury+in+Rats.&rft.au=Brown%2C+R+P%3BVaidya%2C+V+S%3BBeach%2C+B+C%3BToal%2C+M+C%3BLoftin%2C+S+T%3BZhang%2C+J%3BCollings%2C+F+B%3BBonventre%2C+J+V%3BGoering%2C+P+L&rft.aulast=Brown&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Independently Public Toxicogenomics Studies Validate the Transsulfuation Pathway as Potential Liver Toxicity Pathway. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857710; 4813110 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chen, M AU - Schnackenberg, L K AU - Holland, R AU - Beger, R D AU - Isukapalli, S AU - Georgopoulos, P G AU - Welsh, W J AU - Tong, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Liver KW - Animal physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Independently+Public+Toxicogenomics+Studies+Validate+the+Transsulfuation+Pathway+as+Potential+Liver+Toxicity+Pathway.&rft.au=Chen%2C+M%3BSchnackenberg%2C+L+K%3BHolland%2C+R%3BBeger%2C+R+D%3BIsukapalli%2C+S%3BGeorgopoulos%2C+P+G%3BWelsh%2C+W+J%3BTong%2C+W&rft.aulast=Chen&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contaminants and a Globilized Food Supply. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857633; 4813231 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bolger, P M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Contaminants KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Contaminants+and+a+Globilized+Food+Supply.&rft.au=Bolger%2C+P+M&rft.aulast=Bolger&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Irritancy and the Sensitization Potential of Metal Working Fluids and Metal Working Fluid Components. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856615; 4813182 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Anderson, S AU - Brown, K AU - Butterworth, L AU - Fedorowicz, A AU - Beezhold, D AU - Munson, A E AU - Meade, B J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Evaluation+of+Irritancy+and+the+Sensitization+Potential+of+Metal+Working+Fluids+and+Metal+Working+Fluid+Components.&rft.au=Anderson%2C+S%3BBrown%2C+K%3BButterworth%2C+L%3BFedorowicz%2C+A%3BBeezhold%2C+D%3BMunson%2C+A+E%3BMeade%2C+B+J&rft.aulast=Anderson&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Biodistribution of Coated and Uncoated Nano- and Micron-Sized Titanium Dioxide Following Intradermal Administration in Mice. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856470; 4813175 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Gopee, N V AU - Cozart, C AU - Siitonen, P H AU - Smith, C S AU - Walker, N J AU - Howard, P C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Titanium dioxide KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparative+Biodistribution+of+Coated+and+Uncoated+Nano-+and+Micron-Sized+Titanium+Dioxide+Following+Intradermal+Administration+in+Mice.&rft.au=Gopee%2C+N+V%3BCozart%2C+C%3BSiitonen%2C+P+H%3BSmith%2C+C+S%3BWalker%2C+N+J%3BHoward%2C+P+C&rft.aulast=Gopee&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in the Renal Expression of RPA-1, RPA-2, and KIM-1 from Spontaneously Hypertensive Rats (SHR) Given Doxorubicin (DXR) or Mitoxantrone (MTX), with or without Dexrazoxane (DRZ). T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856186; 4812986 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zhang, J AU - Shaw, M AU - Keenan, J AU - Kilty, C AU - Lipshultz, S E AU - Knapton, A AU - Vaidya, V S AU - Bonventre, J V AU - Herman, E H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Doxorubicin KW - Razoxane KW - Kidneys KW - Mitoxantrone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Changes+in+the+Renal+Expression+of+RPA-1%2C+RPA-2%2C+and+KIM-1+from+Spontaneously+Hypertensive+Rats+%28SHR%29+Given+Doxorubicin+%28DXR%29+or+Mitoxantrone+%28MTX%29%2C+with+or+without+Dexrazoxane+%28DRZ%29.&rft.au=Zhang%2C+J%3BShaw%2C+M%3BKeenan%2C+J%3BKilty%2C+C%3BLipshultz%2C+S+E%3BKnapton%2C+A%3BVaidya%2C+V+S%3BBonventre%2C+J+V%3BHerman%2C+E+H&rft.aulast=Zhang&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathways of p-Nonylphenol (NP)-Induced Renal Toxicity Suggested by Global Gene Expression Profiles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40855890; 4812990 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Camacho, L AU - Han, T AU - Fu, X. AU - Cooper, S AU - Fuscoe, J AU - Delclos, K Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Gene expression KW - P-Nonylphenol KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Pathways+of+p-Nonylphenol+%28NP%29-Induced+Renal+Toxicity+Suggested+by+Global+Gene+Expression+Profiles&rft.au=Camacho%2C+L%3BHan%2C+T%3BFu%2C+X.%3BCooper%2C+S%3BFuscoe%2C+J%3BDelclos%2C+K&rft.aulast=Camacho&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICCVAM Recommendations on the use of Five In Vitro Pyrogen Test Methods for Assessing the Potential Pyrogenicity of Pharmaceuticals and Other Products T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40846803; 4811921 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McFarland, R AU - Wind, M AU - Kulpa-Eddy, J AU - Tice, R AU - Stokes, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Pyrogens KW - Pharmaceuticals KW - Pyrogenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=ICCVAM+Recommendations+on+the+use+of+Five+In+Vitro+Pyrogen+Test+Methods+for+Assessing+the+Potential+Pyrogenicity+of+Pharmaceuticals+and+Other+Products&rft.au=McFarland%2C+R%3BWind%2C+M%3BKulpa-Eddy%2C+J%3BTice%2C+R%3BStokes%2C+W&rft.aulast=McFarland&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Responses of Hemizygous Versus Homozygous Tg.AC Mice to the Photocarcinogenic Effect of Ultra-Violet Radiation T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40846674; 4811843 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Howard, P C AU - Walker, N J AU - Gopee, N V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Differential+Responses+of+Hemizygous+Versus+Homozygous+Tg.AC+Mice+to+the+Photocarcinogenic+Effect+of+Ultra-Violet+Radiation&rft.au=Howard%2C+P+C%3BWalker%2C+N+J%3BGopee%2C+N+V&rft.aulast=Howard&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Ferrous Sulfate in Hexavalent Chromium-induced Cytotoxicity and Apoptosis in Human Dermal Fibroblasts T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40846536; 4811835 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sellamuthu, R AU - Joseph, P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cytotoxicity KW - Sulfate KW - Fibroblasts KW - Apoptosis KW - Skin KW - Ferrous sulfate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Role+of+Ferrous+Sulfate+in+Hexavalent+Chromium-induced+Cytotoxicity+and+Apoptosis+in+Human+Dermal+Fibroblasts&rft.au=Sellamuthu%2C+R%3BJoseph%2C+P&rft.aulast=Sellamuthu&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function and Signal Transduction of Nrf2 from a Metal's Perspective. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845873; 4813382 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ma, Q. AU - He, X. Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Signal transduction KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Function+and+Signal+Transduction+of+Nrf2+from+a+Metal%27s+Perspective.&rft.au=Ma%2C+Q.%3BHe%2C+X.&rft.aulast=Ma&rft.aufirst=Q.&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arsenic Induced an Increase in Endothelial Cell Permeability: Involvement of Cytoskeleton Signaling T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845388; 4811756 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ward, R AU - Shi, X AU - Castranova, V AU - Qian, Y Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Permeability KW - Arsenic KW - Signal transduction KW - Cytoskeleton KW - Endothelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Arsenic+Induced+an+Increase+in+Endothelial+Cell+Permeability%3A+Involvement+of+Cytoskeleton+Signaling&rft.au=Ward%2C+R%3BShi%2C+X%3BCastranova%2C+V%3BQian%2C+Y&rft.aulast=Ward&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodistribution of @@u3@H-Pigment Yellow 74, a Tattoo Ink Pigment, Following Intradermal Administration in Mice to Mimic Tattooing T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844733; 4811878 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Couch, L H AU - Gopee, N V AU - Howard, P C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Tattoos KW - Pigments KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Biodistribution+of+%40%40u3%40H-Pigment+Yellow+74%2C+a+Tattoo+Ink+Pigment%2C+Following+Intradermal+Administration+in+Mice+to+Mimic+Tattooing&rft.au=Couch%2C+L+H%3BGopee%2C+N+V%3BHoward%2C+P+C&rft.aulast=Couch&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity and Tissue Distribution of Titanium Dioxide (TiO2) Nanoparticles in Subcutaneously and Intravenously Injected Mice over 6 Months T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844617; 4811859 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Umbreit, T AU - Goering, P L AU - Miller, T J AU - Weaver, J L AU - Francke-Carroll, S AU - Sadrieh, N AU - Kauffman, J AU - Guthrie, J AU - Robertson, J AU - Stratmeyer, M E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Titanium dioxide KW - Mice KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Toxicity+and+Tissue+Distribution+of+Titanium+Dioxide+%28TiO2%29+Nanoparticles+in+Subcutaneously+and+Intravenously+Injected+Mice+over+6+Months&rft.au=Umbreit%2C+T%3BGoering%2C+P+L%3BMiller%2C+T+J%3BWeaver%2C+J+L%3BFrancke-Carroll%2C+S%3BSadrieh%2C+N%3BKauffman%2C+J%3BGuthrie%2C+J%3BRobertson%2C+J%3BStratmeyer%2C+M+E&rft.aulast=Umbreit&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabonomic Analysis of Urine in Cisplatin-Induced Renal Toxicity in Rats and Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844244; 4811636 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Beger, R D AU - Schnackenberg, L AU - Espandiari, P AU - Holland, R AU - Schmitt, T AU - Zhang, J AU - Nagothu, K AU - Portilla, D AU - Hanig, J AU - Sadrieh, N Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Mice KW - Urine KW - Rats KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Metabonomic+Analysis+of+Urine+in+Cisplatin-Induced+Renal+Toxicity+in+Rats+and+Mice&rft.au=Beger%2C+R+D%3BSchnackenberg%2C+L%3BEspandiari%2C+P%3BHolland%2C+R%3BSchmitt%2C+T%3BZhang%2C+J%3BNagothu%2C+K%3BPortilla%2C+D%3BHanig%2C+J%3BSadrieh%2C+N&rft.aulast=Beger&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acrylamide and Glycidamide-Induced Mitochondrial Gene Expression Profiles in Big Blue Transgenic Mice. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842802; 4812665 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Manjanatha, M G AU - Moland, C L AU - Branham, W S AU - Shelton, S D AU - Tareke, E AU - Lee, T AU - Aidoo, A AU - Fuscoe, J C AU - Desai, V G Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Gene expression KW - Acrylamide KW - Mitochondria KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Acrylamide+and+Glycidamide-Induced+Mitochondrial+Gene+Expression+Profiles+in+Big+Blue+Transgenic+Mice.&rft.au=Manjanatha%2C+M+G%3BMoland%2C+C+L%3BBranham%2C+W+S%3BShelton%2C+S+D%3BTareke%2C+E%3BLee%2C+T%3BAidoo%2C+A%3BFuscoe%2C+J+C%3BDesai%2C+V+G&rft.aulast=Manjanatha&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Gene Expression Profiles in Liver of Rats Treated with Riddelliine and Comfrey. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842506; 4812573 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Mei, N AU - Guo, L AU - Dial, S L AU - Fuscoe, J C AU - Chen, T Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Liver KW - Rats KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparison+of+Gene+Expression+Profiles+in+Liver+of+Rats+Treated+with+Riddelliine+and+Comfrey.&rft.au=Mei%2C+N%3BGuo%2C+L%3BDial%2C+S+L%3BFuscoe%2C+J+C%3BChen%2C+T&rft.aulast=Mei&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Chronic Aloe Vera Administration on Colonic Protein Expression and Global DNA Methylation in the Fisher-344 Rat. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842310; 4812618 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Pogribna, M AU - Beland, F A AU - Tryndyak, V AU - Boudreau, M D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - DNA methylation KW - Aloe vera KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Effects+of+Chronic+Aloe+Vera+Administration+on+Colonic+Protein+Expression+and+Global+DNA+Methylation+in+the+Fisher-344+Rat.&rft.au=Pogribna%2C+M%3BBeland%2C+F+A%3BTryndyak%2C+V%3BBoudreau%2C+M+D&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RAW264.7 Macrophage Cells - An In Vitro Alternative Food Safety Testing Platform Compatible with Various Food Types and Food-Borne Toxins. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842180; 4811692 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tolleson, W H AU - Jackson, L S Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxins KW - Food KW - Macrophages KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=RAW264.7+Macrophage+Cells+-+An+In+Vitro+Alternative+Food+Safety+Testing+Platform+Compatible+with+Various+Food+Types+and+Food-Borne+Toxins.&rft.au=Tolleson%2C+W+H%3BJackson%2C+L+S&rft.aulast=Tolleson&rft.aufirst=W&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Cerium Oxide on Rat Primary Alveolar Macrophages T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841380; 4812170 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ma, J Y AU - Zhao, H AU - Barger, M AU - Castranova, V AU - Ma, J K Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cerium KW - Oxides KW - Alveoli KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Effects+of+Cerium+Oxide+on+Rat+Primary+Alveolar+Macrophages&rft.au=Ma%2C+J+Y%3BZhao%2C+H%3BBarger%2C+M%3BCastranova%2C+V%3BMa%2C+J+K&rft.aulast=Ma&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design of an Inhalation Exposure System to Study Spot Welding Fume Characteristics and Biological Effects T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841370; 4812040 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Afshari, A A AU - Antonini, J M AU - Castranova, V AU - Boylstein, R AU - Kanwal, R AU - Frazer, D G Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Biological effects KW - Welding KW - Fumes KW - Inhalation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Design+of+an+Inhalation+Exposure+System+to+Study+Spot+Welding+Fume+Characteristics+and+Biological+Effects&rft.au=Afshari%2C+A+A%3BAntonini%2C+J+M%3BCastranova%2C+V%3BBoylstein%2C+R%3BKanwal%2C+R%3BFrazer%2C+D+G&rft.aulast=Afshari&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhalation of Stainless Steel Welding Fume Results in Dissimilar Inflammatory Responses in the Lungs of A/J and C57BL/6J Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841069; 4812029 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zeidler-Erdely, P C AU - Stone, S AU - Donlin, M AU - Moseley, A AU - Cumpston, J AU - Chen, B T AU - Frazer, D G AU - Young, S AU - Antonini, J M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Welding KW - Steel KW - Fumes KW - Inhalation KW - Mice KW - Stainless steel KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Inhalation+of+Stainless+Steel+Welding+Fume+Results+in+Dissimilar+Inflammatory+Responses+in+the+Lungs+of+A%2FJ+and+C57BL%2F6J+Mice&rft.au=Zeidler-Erdely%2C+P+C%3BStone%2C+S%3BDonlin%2C+M%3BMoseley%2C+A%3BCumpston%2C+J%3BChen%2C+B+T%3BFrazer%2C+D+G%3BYoung%2C+S%3BAntonini%2C+J+M&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Titanium Dioxide Nanoparticles Induce JB6 Cell Apoptosis through Activation of the Caspase-8/Bid Pathway T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840926; 4812063 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zhao, J AU - Bowman, L AU - Zhang, X AU - Ding, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Titanium dioxide KW - Apoptosis KW - Nanoparticles KW - Cell activation KW - BID protein KW - Caspase-8 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Titanium+Dioxide+Nanoparticles+Induce+JB6+Cell+Apoptosis+through+Activation+of+the+Caspase-8%2FBid+Pathway&rft.au=Zhao%2C+J%3BBowman%2C+L%3BZhang%2C+X%3BDing%2C+M&rft.aulast=Zhao&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combined Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840203; 4812151 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Murray, A R AU - Kisin, E AU - Fabisiak, J P AU - Roberts, J R AU - Antonini, J M AU - Kommineni, C AU - Reynolds, J AU - Barchowsky, A AU - Castranova, V AU - Kagan, V AU - Shvedova, A A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Nanotechnology KW - Carbon KW - Lung KW - Infectivity KW - Inflammation KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Combined+Exposure+to+Carbon+Nanotubes+and+Bacteria+Enhances+Pulmonary+Inflammation+and+Infectivity&rft.au=Murray%2C+A+R%3BKisin%2C+E%3BFabisiak%2C+J+P%3BRoberts%2C+J+R%3BAntonini%2C+J+M%3BKommineni%2C+C%3BReynolds%2C+J%3BBarchowsky%2C+A%3BCastranova%2C+V%3BKagan%2C+V%3BShvedova%2C+A+A&rft.aulast=Murray&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of AP-1-MAPKs and NF-kB Signal Pathways by Tungsten Carbide-Cobalt Particles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840052; 4812180 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ding, M AU - Zhao, J AU - Bowman, L AU - Leonard, S AU - Lu, Y. AU - Kisin, E AU - Murray, A AU - Vallyathan, V AU - Castranova, V AU - Shvedova, A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Particulates KW - Tungsten KW - NF-B protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Induction+of+AP-1-MAPKs+and+NF-kB+Signal+Pathways+by+Tungsten+Carbide-Cobalt+Particles&rft.au=Ding%2C+M%3BZhao%2C+J%3BBowman%2C+L%3BLeonard%2C+S%3BLu%2C+Y.%3BKisin%2C+E%3BMurray%2C+A%3BVallyathan%2C+V%3BCastranova%2C+V%3BShvedova%2C+A&rft.aulast=Ding&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICH S2B, a Standard Battery for Genotoxicity Testing of Pharmaceuticals: A Ten Year Perspective. How Well has it Served Us, can it be Improved? T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839590; 4813437 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Jacobson-Kram, D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Genotoxicity testing KW - Batteries KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=ICH+S2B%2C+a+Standard+Battery+for+Genotoxicity+Testing+of+Pharmaceuticals%3A+A+Ten+Year+Perspective.+How+Well+has+it+Served+Us%2C+can+it+be+Improved%3F&rft.au=Jacobson-Kram%2C+D&rft.aulast=Jacobson-Kram&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-Walled Carbon Nanotubes: Geno- and Cyto-Toxic Effects in Lung Fibroblast V79 Cells T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839272; 4812224 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kisin, E AU - Murray, A AU - Keane, M AU - Shi, X AU - Schwegler-Berry, D AU - Gorelik, O AU - Arepalli, S AU - Castranova, V AU - Wallace, W AU - Kagan, V AU - Shvedova, A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Nanotechnology KW - Fibroblasts KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Single-Walled+Carbon+Nanotubes%3A+Geno-+and+Cyto-Toxic+Effects+in+Lung+Fibroblast+V79+Cells&rft.au=Kisin%2C+E%3BMurray%2C+A%3BKeane%2C+M%3BShi%2C+X%3BSchwegler-Berry%2C+D%3BGorelik%2C+O%3BArepalli%2C+S%3BCastranova%2C+V%3BWallace%2C+W%3BKagan%2C+V%3BShvedova%2C+A&rft.aulast=Kisin&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a Mouse Model to Evaluate Pulmonary Inflammation Caused by Floor Dust from a Water-Damaged Building T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839048; 4812031 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Young, S AU - Cox-Ganser, J M AU - Wolfarth, M AU - Antonini, J M AU - Castranova, V AU - Park, J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Dust KW - Animal models KW - Lung KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+a+Mouse+Model+to+Evaluate+Pulmonary+Inflammation+Caused+by+Floor+Dust+from+a+Water-Damaged+Building&rft.au=Young%2C+S%3BCox-Ganser%2C+J+M%3BWolfarth%2C+M%3BAntonini%2C+J+M%3BCastranova%2C+V%3BPark%2C+J&rft.aulast=Young&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Fibrogenic Effects of Dispersed Single Walled Carbon Nanotubes on Human Lung Fibroblasts T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40838384; 4812156 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Wang, L AU - Castranova, V AU - Rojanasakul, Y AU - Lu, Y. AU - Scabilloni, J F AU - Mercer, R R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Nanotechnology KW - Fibroblasts KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Direct+Fibrogenic+Effects+of+Dispersed+Single+Walled+Carbon+Nanotubes+on+Human+Lung+Fibroblasts&rft.au=Wang%2C+L%3BCastranova%2C+V%3BRojanasakul%2C+Y%3BLu%2C+Y.%3BScabilloni%2C+J+F%3BMercer%2C+R+R&rft.aulast=Wang&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extrapulmonary Tissue Distribution of Metals Following Repeated Lung Exposures to Welding Fumes with Different Elemental Profiles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40838050; 4812039 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Antonini, J M AU - Roberts, J R AU - Sriram, K AU - Benkovic, S A AU - O'Callaghan, J P AU - Miller, D B Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Welding KW - Fumes KW - Metals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Extrapulmonary+Tissue+Distribution+of+Metals+Following+Repeated+Lung+Exposures+to+Welding+Fumes+with+Different+Elemental+Profiles&rft.au=Antonini%2C+J+M%3BRoberts%2C+J+R%3BSriram%2C+K%3BBenkovic%2C+S+A%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Antonini&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Genomic Hypomethylation during Hepatocarcinogenesis Induced by Peroxisome Proliferators in Rats. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837821; 4812232 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tryndyak, V AU - Boureiko, A AU - Melnyk, S AU - Rusyn, I AU - Pogribny, I Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Genomics KW - Peroxisomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Mechanism+of+Genomic+Hypomethylation+during+Hepatocarcinogenesis+Induced+by+Peroxisome+Proliferators+in+Rats.&rft.au=Tryndyak%2C+V%3BBoureiko%2C+A%3BMelnyk%2C+S%3BRusyn%2C+I%3BPogribny%2C+I&rft.aulast=Tryndyak&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Regulatory Perspective on Reproductive and Developmental Testing for Biopharmaceuticals. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837339; 4813494 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ghantous, H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=FDA+Regulatory+Perspective+on+Reproductive+and+Developmental+Testing+for+Biopharmaceuticals.&rft.au=Ghantous%2C+H&rft.aulast=Ghantous&rft.aufirst=H&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Perspective on Topical Nanomaterials in Cosmetics. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837192; 4813459 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bronaugh, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cosmetics KW - Nanotechnology KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=FDA+Perspective+on+Topical+Nanomaterials+in+Cosmetics.&rft.au=Bronaugh%2C+R&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of In Vivo Exposure of Methoxychlor to Immature Rats on Serum Progesterone and Estradiol Levels and the Ex Vivo Formation of Progesterone by Theca-Interstitial Cells. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836883; 4812697 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Akgul, Y AU - Derk, R C AU - Murono, E P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Progesterone KW - Estradiol KW - Methoxychlor KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Effects+of+In+Vivo+Exposure+of+Methoxychlor+to+Immature+Rats+on+Serum+Progesterone+and+Estradiol+Levels+and+the+Ex+Vivo+Formation+of+Progesterone+by+Theca-Interstitial+Cells.&rft.au=Akgul%2C+Y%3BDerk%2C+R+C%3BMurono%2C+E+P&rft.aulast=Akgul&rft.aufirst=Y&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Risk Factors in Progressive Massive Fibrosis in Coal Miners. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836811; 4812679 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Yucesoy, B AU - Johnson, V J AU - Fluharty, K AU - Kashon, M L AU - Slaven, J AU - Kissling, G AU - Germolec, D AU - Vallyathan, V AU - Luster, M I Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Coal KW - Occupational safety KW - Mining KW - Fibrosis KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Genetic+Risk+Factors+in+Progressive+Massive+Fibrosis+in+Coal+Miners.&rft.au=Yucesoy%2C+B%3BJohnson%2C+V+J%3BFluharty%2C+K%3BKashon%2C+M+L%3BSlaven%2C+J%3BKissling%2C+G%3BGermolec%2C+D%3BVallyathan%2C+V%3BLuster%2C+M+I&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of 3-nitrobenzanthrone DNA Adducts using On-Line Sample Preparation and Hplc-Electrospray Tandem Mass Spectrometry. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836679; 4812784 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - da Costa, G Gamboa AU - Singh, R AU - Arlt, V M AU - Mirza, A AU - Richards, M AU - Takamura-Enya, T AU - Schmeiser, H H AU - Farmer, P B AU - Phillips, D H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mass spectroscopy KW - DNA adducts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Quantification+of+3-nitrobenzanthrone+DNA+Adducts+using+On-Line+Sample+Preparation+and+Hplc-Electrospray+Tandem+Mass+Spectrometry.&rft.au=da+Costa%2C+G+Gamboa%3BSingh%2C+R%3BArlt%2C+V+M%3BMirza%2C+A%3BRichards%2C+M%3BTakamura-Enya%2C+T%3BSchmeiser%2C+H+H%3BFarmer%2C+P+B%3BPhillips%2C+D+H&rft.aulast=da+Costa&rft.aufirst=G&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - History and Overview of the Threshold of Toxicological Concern (TTC) Concept. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836133; 4813481 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McDougal, A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Historical account KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=History+and+Overview+of+the+Threshold+of+Toxicological+Concern+%28TTC%29+Concept.&rft.au=McDougal%2C+A&rft.aulast=McDougal&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Nanotube Acute Lung Exposure Induces Plasminogen Activator Inhibitor 1 T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836131; 4812005 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Erdely, A AU - Hulderman, T AU - Salmen, R AU - Liston, A AU - Zeidler-Erdely, P C AU - Simeonova, P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Nanotechnology KW - Plasminogen activator inhibitors KW - Carbon KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Carbon+Nanotube+Acute+Lung+Exposure+Induces+Plasminogen+Activator+Inhibitor+1&rft.au=Erdely%2C+A%3BHulderman%2C+T%3BSalmen%2C+R%3BListon%2C+A%3BZeidler-Erdely%2C+P+C%3BSimeonova%2C+P&rft.aulast=Erdely&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of In Vitro, Pharyngeal Aspiration, and Inhalation Results for Single-walled Carbon Nanotubes. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835981; 4813513 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Inhalation KW - Nanotechnology KW - Pharynx KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparison+of+In+Vitro%2C+Pharyngeal+Aspiration%2C+and+Inhalation+Results+for+Single-walled+Carbon+Nanotubes.&rft.au=Castranova%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Genetic Toxicity Test Battery in Hazard Identification for Potential Carcinogenicity of Veterinary Drugs and Feed Ingredients. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835666; 4812466 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Jagannath, D AU - Zhou, T Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Veterinary medicine KW - Toxicity testing KW - Feeds KW - Carcinogenicity KW - Drugs KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+Genetic+Toxicity+Test+Battery+in+Hazard+Identification+for+Potential+Carcinogenicity+of+Veterinary+Drugs+and+Feed+Ingredients.&rft.au=Jagannath%2C+D%3BZhou%2C+T&rft.aulast=Jagannath&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Response to Intratracheal Instillation of Fine or Ultrafine Carbon Black or Titanium Dioxide: Role of Surface Area. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835427; 4812148 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sager, T M AU - Porter, D AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Titanium dioxide KW - Black carbon KW - Surface area KW - Trachea KW - Carbon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Pulmonary+Response+to+Intratracheal+Instillation+of+Fine+or+Ultrafine+Carbon+Black+or+Titanium+Dioxide%3A+Role+of+Surface+Area.&rft.au=Sager%2C+T+M%3BPorter%2C+D%3BCastranova%2C+V&rft.aulast=Sager&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Sandblasted Metal Attenuate or Enhance the Toxicity of Freshly Fractured Silica? T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835331; 4812141 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Pacurari, M AU - Robinson, V AU - Castranova, V AU - Leonard, S S AU - Chen, F AU - Vallyathan, V AU - Barger, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Silica KW - Metals KW - Fractures KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Does+Sandblasted+Metal+Attenuate+or+Enhance+the+Toxicity+of+Freshly+Fractured+Silica%3F&rft.au=Pacurari%2C+M%3BRobinson%2C+V%3BCastranova%2C+V%3BLeonard%2C+S+S%3BChen%2C+F%3BVallyathan%2C+V%3BBarger%2C+M&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Sex- and Age-Related Differences in Heart of Rat Strain Fisher 344 Using Oligonucleotide Microarrays T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835266; 4812121 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Han, T AU - Branham, W S AU - Moland, C L AU - Holland, R AU - Schnackenberg, L K AU - Beger, R D AU - Jones, R AU - Edmondson, R AU - Taylor, J AU - Tong, W AU - Dragan, Y P AU - Fuscoe, J C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Oligonucleotides KW - Heart KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Analysis+of+Sex-+and+Age-Related+Differences+in+Heart+of+Rat+Strain+Fisher+344+Using+Oligonucleotide+Microarrays&rft.au=Han%2C+T%3BBranham%2C+W+S%3BMoland%2C+C+L%3BHolland%2C+R%3BSchnackenberg%2C+L+K%3BBeger%2C+R+D%3BJones%2C+R%3BEdmondson%2C+R%3BTaylor%2C+J%3BTong%2C+W%3BDragan%2C+Y+P%3BFuscoe%2C+J+C&rft.aulast=Han&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity of Silicon Nanoparticles and Microparticles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834487; 4812197 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Choi, J AU - Zhang, Q AU - Hitchins, V M AU - Stratmeyer, M E AU - Goering, P L AU - Vytas, R AU - Wang, N Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Silicon KW - Nanoparticles KW - Microparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Toxicity+of+Silicon+Nanoparticles+and+Microparticles&rft.au=Choi%2C+J%3BZhang%2C+Q%3BHitchins%2C+V+M%3BStratmeyer%2C+M+E%3BGoering%2C+P+L%3BVytas%2C+R%3BWang%2C+N&rft.aulast=Choi&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Toxicity Associated with Non-Dispersed Titanium Dioxide Nanorods. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834412; 4812158 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Roberts, J R AU - Schwegler-Berry, D AU - Leonard, S S AU - Karim, A AU - Tirumala, V AU - Antonini, J M AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Titanium dioxide KW - Lung KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Pulmonary+Toxicity+Associated+with+Non-Dispersed+Titanium+Dioxide+Nanorods.&rft.au=Roberts%2C+J+R%3BSchwegler-Berry%2C+D%3BLeonard%2C+S+S%3BKarim%2C+A%3BTirumala%2C+V%3BAntonini%2C+J+M%3BCastranova%2C+V&rft.aulast=Roberts&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotoxicity Assessment of Silver-25 Nanoparticles: An In Vitro and In Vivo Study T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834402; 4812191 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Rahman, M F AU - Wang, J AU - Patterson, T A AU - Duhart, H M AU - Newport, G D AU - Hussain, S M AU - Schlager, J J AU - Ali, S F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Neurotoxicity+Assessment+of+Silver-25+Nanoparticles%3A+An+In+Vitro+and+In+Vivo+Study&rft.au=Rahman%2C+M+F%3BWang%2C+J%3BPatterson%2C+T+A%3BDuhart%2C+H+M%3BNewport%2C+G+D%3BHussain%2C+S+M%3BSchlager%2C+J+J%3BAli%2C+S+F&rft.aulast=Rahman&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Gaba Agonists on Ketamine-Induced Neurotoxicity in PND-3 Monkey Frontal Cortical Cultures T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40833332; 4811270 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Wang, C AU - Sadovova AU - Patterson, T A AU - Zou, X AU - Zhang, X AU - Hanig, J P AU - Paule, M G AU - Slikker, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40833332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Effect+of+Gaba+Agonists+on+Ketamine-Induced+Neurotoxicity+in+PND-3+Monkey+Frontal+Cortical+Cultures&rft.au=Wang%2C+C%3BSadovova%3BPatterson%2C+T+A%3BZou%2C+X%3BZhang%2C+X%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W&rft.aulast=Wang&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding Toxicity through the Analyses of a Well Designed ToxML Databases T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832784; 4811463 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Storaska, A AU - Arvidson, K AU - Benz, R AU - Brown, R AU - Bower, D AU - Lee, E AU - Marchant, C AU - Sun, G AU - Wood, J AU - Yang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Understanding+Toxicity+through+the+Analyses+of+a+Well+Designed+ToxML+Databases&rft.au=Storaska%2C+A%3BArvidson%2C+K%3BBenz%2C+R%3BBrown%2C+R%3BBower%2C+D%3BLee%2C+E%3BMarchant%2C+C%3BSun%2C+G%3BWood%2C+J%3BYang%2C+C&rft.aulast=Storaska&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxicity of Deoxynivalenol in Rat Liver Clone-9 Cells in Culture T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832739; 4811440 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sahu, S C AU - Garthoff, L H AU - Robl, M G AU - Chirtel, S J AU - Ruggles, D I AU - Flynn, T J AU - Sobotka, T J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cytotoxicity KW - Liver KW - Cell culture KW - Hepatocytes KW - Deoxynivalenol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Cytotoxicity+of+Deoxynivalenol+in+Rat+Liver+Clone-9+Cells+in+Culture&rft.au=Sahu%2C+S+C%3BGarthoff%2C+L+H%3BRobl%2C+M+G%3BChirtel%2C+S+J%3BRuggles%2C+D+I%3BFlynn%2C+T+J%3BSobotka%2C+T+J&rft.aulast=Sahu&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Corticosterone Pretreatment Attenuates Neurodegeneration and Blood-Brain Barrier Disruption Following Excitotoxic Damage from Kainic Acid T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832465; 4811353 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Benkovic, S A AU - O'Callaghan, J P AU - Miller, D B Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Excitotoxicity KW - Corticosterone KW - Neurodegeneration KW - Kainic acid KW - Blood-brain barrier KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Corticosterone+Pretreatment+Attenuates+Neurodegeneration+and+Blood-Brain+Barrier+Disruption+Following+Excitotoxic+Damage+from+Kainic+Acid&rft.au=Benkovic%2C+S+A%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: A. Construction of a Relational Database of Adverse Cardiological Effects Using FDA Archives, Pharmapendium, and Public Sources T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832320; 4811465 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Frid, A A AU - Matthews, E J AU - Kruhlak, N L AU - Benz, R AU - Contrera, J F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Side effects KW - FDA KW - Databases KW - Pharmaceuticals KW - Archives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+A.+Construction+of+a+Relational+Database+of+Adverse+Cardiological+Effects+Using+FDA+Archives%2C+Pharmapendium%2C+and+Public+Sources&rft.au=Frid%2C+A+A%3BMatthews%2C+E+J%3BKruhlak%2C+N+L%3BBenz%2C+R%3BContrera%2C+J+F&rft.aulast=Frid&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational Informatics Systems for Screening the Toxicity of Natural Products T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831817; 4811476 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Valerio, L G AU - Chanderbhan, R F AU - Diaz, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Informatics KW - Natural products KW - Computer applications KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Computational+Informatics+Systems+for+Screening+the+Toxicity+of+Natural+Products&rft.au=Valerio%2C+L+G%3BChanderbhan%2C+R+F%3BDiaz%2C+M&rft.aulast=Valerio&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: B. Prediction of Adverse Cardiological Effects Using MC4PC, Leadscope, Bioepisteme, and MDL-QSAR Software Programs T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831753; 4811472 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Matthews, E J AU - Frid, A A AU - Kruhlak, N L AU - Benz, R AU - Contrera, J F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Side effects KW - Computer programs KW - Lead KW - Software KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+B.+Prediction+of+Adverse+Cardiological+Effects+Using+MC4PC%2C+Leadscope%2C+Bioepisteme%2C+and+MDL-QSAR+Software+Programs&rft.au=Matthews%2C+E+J%3BFrid%2C+A+A%3BKruhlak%2C+N+L%3BBenz%2C+R%3BContrera%2C+J+F&rft.aulast=Matthews&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening the Activation State of Multiple Phosphoproteins Reveals the In Vivo Impact of Stressors on Brain Signaling Pathways Controlling Cellular Structure T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831401; 4811358 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Miller, D B AU - O'Callaghan, J P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Brain KW - Signal transduction KW - Phosphoproteins KW - Screening KW - Ecosystem disturbance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Screening+the+Activation+State+of+Multiple+Phosphoproteins+Reveals+the+In+Vivo+Impact+of+Stressors+on+Brain+Signaling+Pathways+Controlling+Cellular+Structure&rft.au=Miller%2C+D+B%3BO%27Callaghan%2C+J+P&rft.aulast=Miller&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Dermal Penetration of Titanium Dioxide (TiO2) from Sunscreen Formulations Containing Micron- and Nano-scale Particles of TiO2. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830589; 4812172 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sadrieh, N AU - Wokovich, A M AU - Gopee, N V AU - Siitonen, P H AU - Cozart, C R AU - Howard, P C AU - Doub, W H AU - Buhse, L F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Particulates KW - Titanium dioxide KW - Sunscreens KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Analysis+of+Dermal+Penetration+of+Titanium+Dioxide+%28TiO2%29+from+Sunscreen+Formulations+Containing+Micron-+and+Nano-scale+Particles+of+TiO2.&rft.au=Sadrieh%2C+N%3BWokovich%2C+A+M%3BGopee%2C+N+V%3BSiitonen%2C+P+H%3BCozart%2C+C+R%3BHoward%2C+P+C%3BDoub%2C+W+H%3BBuhse%2C+L+F&rft.aulast=Sadrieh&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhalation of Carbon Nanotubes Induces Oxidative Stress and Cytokine Response Causing Respiratory Impairment and Pulmonary Fibrosis in Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830521; 4812154 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Shvedova, A A AU - Kisin, E AU - Murray, A R AU - Johnson, V AU - Gorelik, O AU - Arepalli, S AU - Hubbs, A F AU - Mercer, R R AU - Stone, S AU - Frazer, D AU - Chen, T AU - Deye, G AU - Maynard, A AU - Baron, P AU - Mason, R AU - Kadiiska, M AU - Stadler, K AU - Mouithys-Mickalad, A AU - Castranova, V AU - Kagan, V E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Inhalation KW - Mice KW - Nanotechnology KW - Oxidative stress KW - Fibrosis KW - Lung diseases KW - Cytokines KW - Carbon KW - Nanotubes KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Inhalation+of+Carbon+Nanotubes+Induces+Oxidative+Stress+and+Cytokine+Response+Causing+Respiratory+Impairment+and+Pulmonary+Fibrosis+in+Mice&rft.au=Shvedova%2C+A+A%3BKisin%2C+E%3BMurray%2C+A+R%3BJohnson%2C+V%3BGorelik%2C+O%3BArepalli%2C+S%3BHubbs%2C+A+F%3BMercer%2C+R+R%3BStone%2C+S%3BFrazer%2C+D%3BChen%2C+T%3BDeye%2C+G%3BMaynard%2C+A%3BBaron%2C+P%3BMason%2C+R%3BKadiiska%2C+M%3BStadler%2C+K%3BMouithys-Mickalad%2C+A%3BCastranova%2C+V%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineered Titanium Dioxide Nanowire Toxicity In Vitro and In Vivo T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830464; 4812149 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Porter, D W AU - Holian, A AU - Sriram, K AU - Wu, N. AU - Wolfarth, M AU - Hamilton, R AU - Buford, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Titanium dioxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Engineered+Titanium+Dioxide+Nanowire+Toxicity+In+Vitro+and+In+Vivo&rft.au=Porter%2C+D+W%3BHolian%2C+A%3BSriram%2C+K%3BWu%2C+N.%3BWolfarth%2C+M%3BHamilton%2C+R%3BBuford%2C+M&rft.aulast=Porter&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Protective Effect of L-carnitine on Phencyclidine-induced Cortical Apoptosis in the Developing Rat T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40829814; 4811240 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zou, X AU - Boctor, S Y AU - Sadovova, N AU - Ferguson , S. AU - Paule, M G AU - Slikker, W AU - Wang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Apoptosis KW - Cortex KW - L-Carnitine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40829814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Protective+Effect+of+L-carnitine+on+Phencyclidine-induced+Cortical+Apoptosis+in+the+Developing+Rat&rft.au=Zou%2C+X%3BBoctor%2C+S+Y%3BSadovova%2C+N%3BFerguson+%2C+S.%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Zou&rft.aufirst=X&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Biomarker Genes for the Exposure of Aristolochic Acid in Rat Kidney T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40828542; 4812861 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chen, T AU - Mei, N AU - Guo, L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Bioindicators KW - Kidneys KW - Biomarkers KW - Aristolochic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Determination+of+Biomarker+Genes+for+the+Exposure+of+Aristolochic+Acid+in+Rat+Kidney&rft.au=Chen%2C+T%3BMei%2C+N%3BGuo%2C+L&rft.aulast=Chen&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of NMDA Receptor Subunits in Phencyclidine (PCP)-Induced Neuronal Apoptosis in Rats T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40825840; 4811272 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Paule, M G AU - Sadovova, N AU - Zou, X AU - Zhang, X AU - Slikker, W AU - Wang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Apoptosis KW - N-Methyl-D-aspartic acid receptors KW - Phencyclidine KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Role+of+NMDA+Receptor+Subunits+in+Phencyclidine+%28PCP%29-Induced+Neuronal+Apoptosis+in+Rats&rft.au=Paule%2C+M+G%3BSadovova%2C+N%3BZou%2C+X%3BZhang%2C+X%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of Antioxidant Defense and DNA Repair Systems during 2-acetylaminofluorene-induced Hepatocarcinogenesis in Rats T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40825707; 4811541 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bagnyukova, T V AU - Powell, C L AU - Montgomery, B AU - Beland, F A AU - Pogribny, I P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Antioxidants KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Disruption+of+Antioxidant+Defense+and+DNA+Repair+Systems+during+2-acetylaminofluorene-induced+Hepatocarcinogenesis+in+Rats&rft.au=Bagnyukova%2C+T+V%3BPowell%2C+C+L%3BMontgomery%2C+B%3BBeland%2C+F+A%3BPogribny%2C+I+P&rft.aulast=Bagnyukova&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The Smallpox Vaccine Injury Compensation Program. AN - 70313329; 18284357 AB - In January 2003, the Secretary of the US Department of Health and Human Services (DHHS) announced that certain individuals should receive smallpox vaccine or other countermeasures to be prepared to serve the civilian population in the event of a smallpox bioterrorism event. In April 2003, Congress passed and the President signed the Smallpox Emergency Personnel Protection Act of 2003. This act created the Smallpox Vaccine Injury Compensation Program to provide medical and lost employment income coverage as a payer of last resort to persons who sustain a covered medical injury as a direct result of receiving smallpox vaccination voluntarily under a DHHS-approved smallpox emergency response plan. As of September 2006, 62 persons had requested benefits, of whom 19 had been determined to be medically eligible, 27 were denied benefits, and 16 submitted the request after the legislatively defined filing deadline. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Clark, Paul T AU - Levin, Stan AD - US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, and Smallpox Vaccine Injury Compensation Program, Rockville, Maryland, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - S179 EP - S181 VL - 46 Suppl 3 KW - DryVax vaccine KW - 0 KW - Smallpox Vaccine KW - Index Medicus KW - United States KW - Eligibility Determination KW - Adverse Drug Reaction Reporting Systems -- economics KW - Humans KW - Disability Evaluation KW - Income KW - Insurance, Liability -- economics KW - Mass Vaccination -- adverse effects KW - Bioterrorism -- prevention & control KW - Smallpox Vaccine -- adverse effects KW - Mass Vaccination -- economics KW - Insurance, Liability -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70313329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=The+Smallpox+Vaccine+Injury+Compensation+Program.&rft.au=Clark%2C+Paul+T%3BLevin%2C+Stan&rft.aulast=Clark&rft.aufirst=Paul&rft.date=2008-03-15&rft.volume=46+Suppl+3&rft.issue=&rft.spage=S179&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F524381 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-04 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/524381 ER - TY - CPAPER T1 - An Antibody-Based Multiplex Bead Assay to Determine the Potency and Composition of Allergen Extracts T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40730983; 4763719 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - deVore, N AU - Slater, J E Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Allergens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=An+Antibody-Based+Multiplex+Bead+Assay+to+Determine+the+Potency+and+Composition+of+Allergen+Extracts&rft.au=deVore%2C+N%3BSlater%2C+J+E&rft.aulast=deVore&rft.aufirst=N&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Fungal Isolates using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40722797; 4763476 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Green, B J AU - Hettick, J M AU - Schmechel, D AU - Kashon, M L AU - Slaven, J E AU - Blachere, F M AU - Buskirk, A AU - Janotka, E AU - Siegel, P D AU - Beezhold, D H Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Mass spectroscopy KW - Lasers KW - Desorption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40722797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Identifying+Fungal+Isolates+using+Matrix-Assisted+Laser+Desorption%2FIonization+Time-of-Flight+Mass+Spectrometry&rft.au=Green%2C+B+J%3BHettick%2C+J+M%3BSchmechel%2C+D%3BKashon%2C+M+L%3BSlaven%2C+J+E%3BBlachere%2C+F+M%3BBuskirk%2C+A%3BJanotka%2C+E%3BSiegel%2C+P+D%3BBeezhold%2C+D+H&rft.aulast=Green&rft.aufirst=B&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated Serum IgE Concentrations in Systemic Lupus Erythematosus are Related to History of Childhood Allergy, Asthma, and Hives T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40717820; 4764215 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Biagini, R E AU - Smith, J P AU - Sammons, D L AU - Mackenzie, B A AU - Parks, C G Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Respiratory diseases KW - Asthma KW - Historical account KW - Children KW - Systemic lupus erythematosus KW - Hypersensitivity KW - Immunoglobulin E KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Elevated+Serum+IgE+Concentrations+in+Systemic+Lupus+Erythematosus+are+Related+to+History+of+Childhood+Allergy%2C+Asthma%2C+and+Hives&rft.au=Biagini%2C+R+E%3BSmith%2C+J+P%3BSammons%2C+D+L%3BMackenzie%2C+B+A%3BParks%2C+C+G&rft.aulast=Biagini&rft.aufirst=R&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS. AN - 70362454; 18257525 AB - A multiclass method has been developed for the determination and confirmation in honey of tetracyclines (chlortetracycline, doxycycline, oxytetracycline, and tetracycline), fluoroquinolones (ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, and sarafloxacin), macrolides (tylosin), lincosamides (lincomycin), aminoglycosides (streptomycin), sulfonamides (sulfathiazole), phenicols (chloramphenicol), and fumagillin residues using liquid chromatography tandem mass spectrometry (LC-MS/MS). Erythromycin (a macrolide) and monensin (an ionophore) can be detected and confirmed but not quantitated. Honey samples (approximately 2 g) are dissolved in 10 mL of water and centrifuged. An aliquot of the supernatant is used to determine streptomycin. The remaining supernatant is filtered through a fine-mesh nylon fabric and cleaned up by solid phase extraction. After solvent evaporation and sample reconstitution, 15 antibiotics are assayed by LC-MS/MS using electrospray ionization (ESI) in positive ion mode. Afterward, chloramphenicol is assayed using ESI in negative ion mode. The method has been validated at the low part per billion levels for most of the drugs with accuracies between 65 and 104% and coefficients of variation less than 17%. The evaluation of matrix effects caused by honey of different floral origin is presented. JF - Journal of agricultural and food chemistry AU - Lopez, Mayda I AU - Pettis, Jeffery S AU - Smith, I Barton AU - Chu, Pak-Sin AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. mayda.lopez@fda.hhs.gov Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 SP - 1553 EP - 1559 VL - 56 IS - 5 SN - 0021-8561, 0021-8561 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Honey -- analysis KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Food Contamination -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Multiclass+determination+and+confirmation+of+antibiotic+residues+in+honey+using+LC-MS%2FMS.&rft.au=Lopez%2C+Mayda+I%3BPettis%2C+Jeffery+S%3BSmith%2C+I+Barton%3BChu%2C+Pak-Sin&rft.aulast=Lopez&rft.aufirst=Mayda&rft.date=2008-03-12&rft.volume=56&rft.issue=5&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf073236w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2008-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf073236w ER - TY - CPAPER T1 - Genotype Distribution in Acute and Chronic Hepatitis B in the Netherlands T2 - 2008 Winter and Annual Meeting of the European Society for Clinical Virology (ESCV 2008) AN - 40782993; 4792268 JF - 2008 Winter and Annual Meeting of the European Society for Clinical Virology (ESCV 2008) AU - Bruisten, Sylvia AU - van Houdt, Robin AU - Koedijk, Femke AU - Op de Coul, Eline AU - Coutinho, Roel AU - Boot, Hein Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 KW - Netherlands KW - Hepatitis B KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Winter+and+Annual+Meeting+of+the+European+Society+for+Clinical+Virology+%28ESCV+2008%29&rft.atitle=Genotype+Distribution+in+Acute+and+Chronic+Hepatitis+B+in+the+Netherlands&rft.au=Bruisten%2C+Sylvia%3Bvan+Houdt%2C+Robin%3BKoedijk%2C+Femke%3BOp+de+Coul%2C+Eline%3BCoutinho%2C+Roel%3BBoot%2C+Hein&rft.aulast=Bruisten&rft.aufirst=Sylvia&rft.date=2008-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Winter+and+Annual+Meeting+of+the+European+Society+for+Clinical+Virology+%28ESCV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.escv2008.fi/abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Medicine. Moving toward transparency of clinical trials. AN - 70370251; 18323436 JF - Science (New York, N.Y.) AU - Zarin, Deborah A AU - Tse, Tony AD - National Library of Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20894, USA. dzarin@mail.nih.gov Y1 - 2008/03/07/ PY - 2008 DA - 2008 Mar 07 SP - 1340 EP - 1342 VL - 319 IS - 5868 KW - Index Medicus KW - United States KW - Intellectual Property KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Publishing KW - Public Policy KW - Disclosure KW - Registries KW - Access to Information KW - Clinical Trials as Topic -- standards KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70370251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Medicine.+Moving+toward+transparency+of+clinical+trials.&rft.au=Zarin%2C+Deborah+A%3BTse%2C+Tony&rft.aulast=Zarin&rft.aufirst=Deborah&rft.date=2008-03-07&rft.volume=319&rft.issue=5868&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1153632 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2004 Sep 15;292(11):1359-62 [15355937] JAMA. 2004 Sep 15;292(11):1363-4 [15355936] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] J R Soc Med. 1995;88 Suppl 24:12-6 [7776320] JAMA. 2004 Dec 1;292(21):2622-31 [15572720] Circulation. 2005 Sep 27;112(13):2040-2 [16172264] N Engl J Med. 2005 Dec 29;353(26):2779-87 [16382064] Science. 2006 Jan 13;311(5758):180-1 [16410509] BMJ. 2006 Mar 25;332(7543):677-8 [16554332] Lancet. 2006 May 20;367(9523):1631-3 [16714166] N Engl J Med. 2006 Nov 23;355(21):2169-71 [17124012] BMJ. 2007 Jan 20;334(7585):120-3 [17235089] N Engl J Med. 2007 Apr 19;356(16):1601-4 [17442902] JAMA. 2007 May 16;297(19):2112-20 [17507347] N Engl J Med. 2007 Jun 14;356(24):2457-71 [17517853] N Engl J Med. 2007 Jun 14;356(24):2522-4 [17517854] N Engl J Med. 2007 Jun 28;356(26):2734-6 [17548427] Nat Rev Drug Discov. 2007 Jul;6(7):532-9 [17491596] Arch Intern Med. 2007 Aug 13-27;167(15):1576-80 [17698679] N Engl J Med. 2007 Aug 30;357(9):844-6 [17687124] N Engl J Med. 2007 Oct 25;357(17):1756-7 [17914035] Nat Clin Pract Neurol. 2007 Nov;3(11):590-1 [17876349] N Engl J Med. 2007 Nov 29;357(22):2219-21 [18046025] N Engl J Med. 2008 Jan 17;358(3):252-60 [18199864] N Engl J Med. 2006 Nov 23;355(21):2171-3 [17124013] J Clin Oncol. 1986 Oct;4(10):1529-41 [3760920] JAMA. 2002 Jul 17;288(3):363-5 [12117402] Ann Intern Med. 2002 Aug 20;137(4):290 [12186521] Science. 2004 Feb 6;303(5659):745 [14764841] Comment In: Science. 2008 Oct 3;322(5898):44-6 [18832629] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1153632 ER - TY - CPAPER T1 - FOXP3 Expression in HUM Cancer Cells T2 - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AN - 40976315; 4874324 JF - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AU - Karanikas, Viaos AU - Speletas, Matthaios AU - Zamanakou, Maria AU - Kalala, Fani AU - Loules, Gedeon AU - Kerenidi, Theodora AU - Barda, Aggeliki AU - Gourgoulianis, Konstantinos AU - Germenis, Anastasios Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 KW - Cancer KW - Foxp3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40976315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.atitle=FOXP3+Expression+in+HUM+Cancer+Cells&rft.au=Karanikas%2C+Viaos%3BSpeletas%2C+Matthaios%3BZamanakou%2C+Maria%3BKalala%2C+Fani%3BLoules%2C+Gedeon%3BKerenidi%2C+Theodora%3BBarda%2C+Aggeliki%3BGourgoulianis%2C+Konstantinos%3BGermenis%2C+Anastasios&rft.aulast=Karanikas&rft.aufirst=Viaos&rft.date=2008-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iospress.metapress.com/content/p39v6085561v/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Drug Safety Surveillance in China and Other Countries: A Review and Comparison AN - 754135877; 201020673 AB - Objectives: Drug safety and postmarketing surveillance have become important public health issues in China. This study reviews the relatively new drug safety surveillance system in China and compares it with the systems in the United States and Europe. Methods: An extensive literature review was conducted in the following four areas: 1) the organizational structure of the State Food and Drug Administration (SFDA) in China; 2) the development of an adverse drug reaction (ADR) monitoring system in China; 3) regulatory issues related to drug safety in China; and 4) similarities and differences between drug safety surveillance in China and surveillance in the United States and Europe. Results: The SFDA oversees an extensive network of drug safety 'watchdogs,' including the China National Center for ADR Monitoring and 32 regional centers throughout China. China's system has faced a number of recent challenges. It has had to respond quickly to the withdrawal of various high-profile drugs like Vioxx (rofecoxib) and Baycol (cerivastatin) from other markets. Together with China's Ministry of Health, the SFDA has faced several unique drug safety events. Three of those events, involving the injectable form of the heartleaf houttuyinia herb (Yu Xing Cao), Armillarisni A injections, and clindamycin glucose infusions (Xinfu), are discussed. The rapid development of drug safety surveillance in China is manifested in extensive organizational structure, development of large databases, and laws and regulations supporting drug safety. The two major laws are the China Drug Administration Law issued in February 2001 and the Regulation for the Administration of ADR Reporting and Monitoring issued in March 2004. The study also discusses and compares recent developments in drug safety surveillance in the United States and the European Union. These developments will most likely have implications for the Chinese system in the near future. Conclusions: While postmarketing surveillance guidelines are not yet available in China, we fully expect their eventual issuance after adaptation to the particular culture and clinical practices in China. Adapted from the source document. JF - Value in Health AU - Du, Wenmin AU - Guo, Jeff J AU - Jing, Yonghua AU - Li, Xing AU - Kelton, Christina M L AD - Shanghai Center for Adverse Drug Reaction Monitoring, Shanghai Food and Drug Administration, Shanghai, China jeff.guo@uc.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - S130 EP - S136 PB - Wiley Publishing, Malden, MA 02148 VL - 11 IS - s1 SN - 1098-3015, 1098-3015 KW - Safety regulations KW - Safety KW - Europe KW - Regulations KW - Surveillance KW - China KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+Health&rft.atitle=Drug+Safety+Surveillance+in+China+and+Other+Countries%3A+A+Review+and+Comparison&rft.au=Du%2C+Wenmin%3BGuo%2C+Jeff+J%3BJing%2C+Yonghua%3BLi%2C+Xing%3BKelton%2C+Christina+M+L&rft.aulast=Du&rft.aufirst=Wenmin&rft.date=2008-03-01&rft.volume=11&rft.issue=s1&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Value+in+Health&rft.issn=10983015&rft_id=info:doi/10.1111%2Fj.1524-4733.2008.00377.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - China; Surveillance; Safety; Safety regulations; Regulations; Europe DO - http://dx.doi.org/10.1111/j.1524-4733.2008.00377.x ER - TY - JOUR T1 - Characterization of high intensity focused ultrasound transducers using acoustic streaming. AN - 742777089; pmid-18345858 AB - A new approach for characterizing high intensity focused ultrasound (HIFU) transducers is presented. The technique is based upon the acoustic streaming field generated by absorption of the HIFU beam in a liquid medium. The streaming field is quantified using digital particle image velocimetry, and a numerical algorithm is employed to compute the acoustic intensity field giving rise to the observed streaming field. The method as presented here is applicable to moderate intensity regimes, above the intensities which may be damaging to conventional hydrophones, but below the levels where nonlinear propagation effects are appreciable. Intensity fields and acoustic powers predicted using the streaming method were found to agree within 10% with measurements obtained using hydrophones and radiation force balances. Besides acoustic intensity fields, the streaming technique may be used to determine other important HIFU parameters, such as beam tilt angle or absorption of the propagation medium. JF - The Journal of the Acoustical Society of America AU - Hariharan, Prasanna AU - Myers, Matthew R AU - Robinson, Ronald A AU - Maruvada, Subha H AU - Sliwa, Jack AU - Banerjee, Rupak K AD - Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1706 EP - 1719 VL - 123 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Absorption KW - Acoustics -- instrumentation KW - Transducers KW - Ultrasonics KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Characterization+of+high+intensity+focused+ultrasound+transducers+using+acoustic+streaming.&rft.au=Hariharan%2C+Prasanna%3BMyers%2C+Matthew+R%3BRobinson%2C+Ronald+A%3BMaruvada%2C+Subha+H%3BSliwa%2C+Jack%3BBanerjee%2C+Rupak+K&rft.aulast=Hariharan&rft.aufirst=Prasanna&rft.date=2008-03-01&rft.volume=123&rft.issue=3&rft.spage=1706&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Responder safety and health: preparing for future disasters. AN - 71621894; 18500715 AB - This article reviews lessons learned about managing the safety and health of workers who were involved in disaster response, recovery, and cleanup after the 2001 World Trade Center (WTC) disaster. The first two sections review ongoing responder health burdens and the tragic toll of this disaster from a worker safety and health perspective. The remaining sections address changes in federal infrastructure, response planning, and resources for protection of response and recovery personnel. Proper preparation includes pre-event and "just-in-time" disaster-worker training on likely hazards, organizational assets for hazard monitoring, and hands-on instruction in the use of assigned protective equipment. Good planning includes predeployment medical review to ensure "fitness for duty" and considers the following: (1) personal risk factors, (2) hazards likely to be associated with particular field locations, and (3) risks involved with assigned tasks (eg, workload and pace, work/rest cycles, available resources, and team/supervisory dynamics). Planning also should address worker health surveillance, medical monitoring, and availability of medical care (including mental health services). Disaster safety managers should anticipate likely hazards within planning scenarios and prepare asset inventories to facilitate making timely safety decisions. Disaster safety management begins immediately and provides ongoing real-time guidance to incident leadership at all levels of government. Robust standards must be met to reliably protect workers/responders. An integrated and measurable multiagency safety management function must be built into the incident command system before an incident occurs. This function delineates roles and responsibilities for rapid exposure assessments, ensuring cross-agency consistency in data interpretation, and timely, effective communication of information and control strategies. The ability to perform this safety management function should be tested and evaluated in exercise simulations and drills at multiple levels. Joint planning and exercising of the safety management plan and its function are effective ways to build interagency relationships and to be more systemic in managing logistics for safety equipment and converging personnel. Planning must include mechanisms to enable safety decisions to be implemented-such as effective and rapid scene control (site access), personnel tracking, and safety enforcement. Worker safety and health preparedness and leadership are essential for protecting workers and promoting resiliency among personnel involved in disaster response, recovery, and cleanup. Copyright (c) 2008 Mount Sinai School of Medicine JF - The Mount Sinai journal of medicine, New York AU - Reissman, Dori B AU - Howard, John AD - National Institute for Occupational Safety and Health, Washington, DC, USA. DReissman@cdc.gov PY - 2008 SP - 135 EP - 141 VL - 75 IS - 2 SN - 0027-2507, 0027-2507 KW - Index Medicus KW - Occupational Health KW - Volunteers KW - New York City -- epidemiology KW - Humans KW - Occupational Diseases -- prevention & control KW - Lung Diseases -- epidemiology KW - United States -- epidemiology KW - Lung Diseases -- prevention & control KW - Relief Work KW - Occupational Exposure -- adverse effects KW - Disaster Planning KW - Safety Management KW - September 11 Terrorist Attacks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71621894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=Responder+safety+and+health%3A+preparing+for+future+disasters.&rft.au=Reissman%2C+Dori+B%3BHoward%2C+John&rft.aulast=Reissman&rft.aufirst=Dori&rft.date=2008-03-01&rft.volume=75&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/10.1002%2Fmsj.20024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/msj.20024 ER - TY - JOUR T1 - The 9/11 World Trade Center disaster: past and future. AN - 71616769; 18500707 JF - The Mount Sinai journal of medicine, New York AU - Howard, John AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, World Trade Center Health Programs, US Department of Health and Human Services, Washington, DC, USA. PY - 2008 SP - 65 EP - 66 VL - 75 IS - 2 SN - 0027-2507, 0027-2507 KW - Particulate Matter KW - 0 KW - Index Medicus KW - New York City KW - Humans KW - Occupational Exposure -- adverse effects KW - Inhalation Exposure -- adverse effects KW - Disaster Planning -- trends KW - Particulate Matter -- adverse effects KW - Environmental Exposure -- adverse effects KW - September 11 Terrorist Attacks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71616769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=The+9%2F11+World+Trade+Center+disaster%3A+past+and+future.&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2008-03-01&rft.volume=75&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/10.1002%2Fmsj.20037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/msj.20037 ER - TY - JOUR T1 - Detection of ricin in food using electrochemiluminescence-based technology. AN - 70738825; 18476351 AB - Ricin is a toxic ribosome inactivating protein (RIP-II) present in beans of the castor plant, Ricinus communis. Its potential as a biodefense threat has made the rapid, sensitive detection of ricin in food important to the U.S. Food and Drug Administration. Samples of juice, dairy products, soda, vegetables, bakery products, chocolate, and condiments were spiked with varying concentrations of ricin and analyzed using a 96-well format, electrochemiluminescence (ECL) immunoassay. Assay configurations included the use of a monoclonal capture antibody coupled with either a polyclonal or monoclonal detector antibody. The samples and detector antibodies were either added sequentially or in combination during the capture step. Using the polyclonal antibody, 0.04 ng/mL ricin was detected in analytical samples prepared from several beverages. By simultaneously incubating the sample with detector antibody, it was possible to decrease the assay time to a single 20 min incubation step with a limit of detection <10 ng/mL. Assays run according to this single incubation step exhibited a hook effect (decrease in signal at high concentrations of ricin), but because of the large signal-to-noise ratio associated with the ECL assay, the response remained above background and detectable. Thus, the ECL assay was uniquely suited for the screening of samples for ricin. JF - Journal of AOAC International AU - Garber, Eric A E AU - O'Brien, Thomas W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Bioanalytical Chemistry, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. Eric.Garber@fda.hhs.gov PY - 2008 SP - 376 EP - 382 VL - 91 IS - 2 SN - 1060-3271, 1060-3271 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay KW - Luminescent Measurements -- methods KW - Food Analysis -- methods KW - Ricin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70738825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+ricin+in+food+using+electrochemiluminescence-based+technology.&rft.au=Garber%2C+Eric+A+E%3BO%27Brien%2C+Thomas+W&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-03-01&rft.volume=91&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A rapid multiresidue method for determination of pesticides in fruits and vegetables by using acetonitrile extraction/partitioning and solid-phase extraction column cleanup. AN - 70716511; 18476358 AB - A modification of a rapid and inexpensive multiresidue method for determination of pesticides in fruits and vegetables (QuEChERS method) is presented. Samples were extracted by shaking with acetic acid-acetonitrile (1 + 99). Water was removed by liquid-liquid partitioning with magnesium sulfate and sodium acetate. The extract was subjected to a single solid-phase extraction (SPE) column cleanup, which produced a cleaner extract than did the dispersive SPE cleanup used in the original QuEChERS method. Recovery data were obtained for 316 pesticide residues, at levels ranging from 20 ppb to 1.0 ppm. Data were provided by 3 different laboratories. The modified QuEChERS method resulted in a 65% reduction in solvent usage, when compared with the traditional multiresidue methods previously used in our laboratories. JF - Journal of AOAC International AU - Schenck, Frank J AU - Brown, Amy N AU - Podhorniak, Lynda V AU - Parker, Alesia AU - Reliford, Michelle AU - Wong, Jon W AD - U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309, USA. Frank.Schenck@fda.hhs.gov PY - 2008 SP - 422 EP - 438 VL - 91 IS - 2 SN - 1060-3271, 1060-3271 KW - Acetonitriles KW - 0 KW - Pesticide Residues KW - acetonitrile KW - Z072SB282N KW - Index Medicus KW - Vegetables -- chemistry KW - Solid Phase Extraction -- methods KW - Pesticide Residues -- analysis KW - Fruit -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70716511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=A+rapid+multiresidue+method+for+determination+of+pesticides+in+fruits+and+vegetables+by+using+acetonitrile+extraction%2Fpartitioning+and+solid-phase+extraction+column+cleanup.&rft.au=Schenck%2C+Frank+J%3BBrown%2C+Amy+N%3BPodhorniak%2C+Lynda+V%3BParker%2C+Alesia%3BReliford%2C+Michelle%3BWong%2C+Jon+W&rft.aulast=Schenck&rft.aufirst=Frank&rft.date=2008-03-01&rft.volume=91&rft.issue=2&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial behavioral syndromes and past-year physical health among adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70487391; 18348594 AB - To describe associations of DSM-IV antisocial personality disorder (ASPD), DSM-IV conduct disorder without progression to ASPD (CD-only), and syndromal antisocial behavior in adulthood without conduct disorder before age 15 years (AABS, not a DSM-IV diagnosis) with past-year physical health status and hospital care utilization in the general U.S. adult population. This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093, response rate = 81%). Respondents were classified according to whether they met criteria for ASPD, AABS, CD-only, or no antisocial syndrome. Associations of antisocial syndromes with physical health status and care utilization were examined using normal theory and logistic regression. ASPD and AABS were significantly but modestly associated with total past-year medical conditions, coronary heart and gastrointestinal diseases, and numbers of inpatient hospitalizations, inpatient days, emergency department visits, and clinically significant injuries (all p < .05). ASPD was also associated with liver disease, arthritis, and lower scores on the Medical Outcomes Study 12-Item Short-Form Health Survey, version 2 (SF-12v2) physical component summary, role physical, and bodily pain scales (all p < .05). AABS was associated with noncoronary heart disease, lower scores on the SF-12v2 general health and vitality scales, and, among men, arthritis (all p < .05). CD-only was associated with single but not multiple inpatient hospitalizations, emergency department visits, and clinically significant injuries (all p < .05). Estimates of burden related to antisocial behavioral syndromes need to consider associated physical health problems. Prevention and treatment guidelines for injuries and common chronic diseases may need to address comorbid antisociality, and interventions targeting antisociality may need to consider general health status, including prevention and management of injuries and chronic diseases. JF - The Journal of clinical psychiatry AU - Goldstein, Risë B AU - Dawson, Deborah A AU - Chou, S Patricia AU - Ruan, W June AU - Saha, Tulshi D AU - Pickering, Roger P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. goldster@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 368 EP - 380 VL - 69 IS - 3 KW - Index Medicus KW - Mood Disorders -- diagnosis KW - Insurance, Health -- statistics & numerical data KW - Tobacco Use Disorder -- epidemiology KW - Anxiety Disorders -- diagnosis KW - Humans KW - Body Mass Index KW - Comorbidity KW - Adult KW - Tobacco Use Disorder -- diagnosis KW - Mood Disorders -- epidemiology KW - Adolescent KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Time Factors KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Prevalence KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Health Surveys KW - Health Status KW - Conduct Disorder -- epidemiology KW - Antisocial Personality Disorder -- diagnosis KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70487391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Antisocial+behavioral+syndromes+and+past-year+physical+health+among+adults+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BDawson%2C+Deborah+A%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2008-03-01&rft.volume=69&rft.issue=3&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychiatry 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2017-01-18 ER - TY - JOUR T1 - Detection of melamine using commercial enzyme-linked immunosorbent assay technology. AN - 70484137; 18389705 AB - Recent cases of adulteration with melamine have led to the need for rapid and reliable screening methods. To meet this need, commercial enzyme-linked immunosorbent assay (ELISA) test kits for the detection of triazines were evaluated. The recently released Melamine Plate kit (Abraxis, Warminster, Pa.) displayed a limit of detection of 9 ng/ml for melamine in phosphate-buffered saline (PBS) and approximately 1 microg/ml for melamine added to dog food. An atrazine ELISA test kit produced by Abraxis required 0.2 mg/ml to generate a response more than four times the standard deviation from background. In contrast, with the EnviroGard Triazine Plate kit (Strategic Diagnostics, Inc., Newark, Del.), 1.5 mg/ml melamine in PBS generated a signal only one standard deviation from background, which was insufficient to define a limit of detection. Extraction based on dilution with 105 mM sodium phosphate/75 mM NaCl/2.5% nonfat milk/0.05% Tween 20 (UD) enabled detection of fivefold less melamine in dog food than did use of the procedure recommended by the manufacturer, which entailed extraction into 60% methanol, sonication, centrifugation, filtration, and further dilution into 10% methanol/PBS. Using the Abraxis Melamine ELISA, both extraction protocols yielded identical results with a dog food sample adulterated with melamine. The recovery of melamine spiked into gravy from dog food using UD was 74% +/- 4%. In conclusion, the recently released Abraxis ELISA for melamine proved to be a useful alternative to more cumbersome methods. JF - Journal of food protection AU - Garber, Eric A E AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740, USA. eric.garber@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 590 EP - 594 VL - 71 IS - 3 SN - 0362-028X, 0362-028X KW - Herbicides KW - 0 KW - Pesticide Residues KW - Reagent Kits, Diagnostic KW - Triazines KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Consumer Product Safety KW - Reproducibility of Results KW - Humans KW - Pesticide Residues -- analysis KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Triazines -- analysis KW - Herbicides -- analysis KW - Food Contamination -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70484137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Detection+of+melamine+using+commercial+enzyme-linked+immunosorbent+assay+technology.&rft.au=Garber%2C+Eric+A+E&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-03-01&rft.volume=71&rft.issue=3&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-12 N1 - Date created - 2008-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Compound cytotoxicity profiling using quantitative high-throughput screening. AN - 70391794; 18335092 AB - The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects. The National Toxicology Program and the National Institutes of Health Chemical Genomics Center are collaborating to identify a battery of cell-based screens to prioritize compounds for further toxicologic evaluation. A collection of 1,408 compounds previously tested in one or more traditional toxicologic assays were profiled for cytotoxicity using quantitative high-throughput screening (qHTS) in 13 human and rodent cell types derived from six common targets of xenobiotic toxicity (liver, blood, kidney, nerve, lung, skin). Selected cytotoxicants were further tested to define response kinetics. qHTS of these compounds produced robust and reproducible results, which allowed cross-compound, cross-cell type, and cross-species comparisons. Some compounds were cytotoxic to all cell types at similar concentrations, whereas others exhibited species- or cell type-specific cytotoxicity. Closely related cell types and analogous cell types in human and rodent frequently showed different patterns of cytotoxicity. Some compounds inducing similar levels of cytotoxicity showed distinct time dependence in kinetic studies, consistent with known mechanisms of toxicity. The generation of high-quality cytotoxicity data on this large library of known compounds using qHTS demonstrates the potential of this methodology to profile a much broader array of assays and compounds, which, in aggregate, may be valuable for prioritizing compounds for further toxicologic evaluation, identifying compounds with particular mechanisms of action, and potentially predicting in vivo biological response. JF - Environmental health perspectives AU - Xia, Menghang AU - Huang, Ruili AU - Witt, Kristine L AU - Southall, Noel AU - Fostel, Jennifer AU - Cho, Ming-Hsuang AU - Jadhav, Ajit AU - Smith, Cynthia S AU - Inglese, James AU - Portier, Christopher J AU - Tice, Raymond R AU - Austin, Christopher P AD - NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 284 EP - 291 VL - 116 IS - 3 SN - 0091-6765, 0091-6765 KW - Xenobiotics KW - 0 KW - Index Medicus KW - cell viability KW - NTP 1,408 compound library KW - qHTS KW - RT-CES KW - 1,536-well KW - PubChem KW - Rats KW - Animals KW - Reproducibility of Results KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Mice KW - Toxicity Tests -- methods KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70391794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Compound+cytotoxicity+profiling+using+quantitative+high-throughput+screening.&rft.au=Xia%2C+Menghang%3BHuang%2C+Ruili%3BWitt%2C+Kristine+L%3BSouthall%2C+Noel%3BFostel%2C+Jennifer%3BCho%2C+Ming-Hsuang%3BJadhav%2C+Ajit%3BSmith%2C+Cynthia+S%3BInglese%2C+James%3BPortier%2C+Christopher+J%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Xia&rft.aufirst=Menghang&rft.date=2008-03-01&rft.volume=116&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10727 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Ther. 1999 Sep;83(3):181-215 [10576292] Mutagenesis. 2007 Jan;22(1):5-13 [17142828] Biochem Biophys Res Commun. 2000 Jul 14;273(3):1095-8 [10891377] Int J Hyg Environ Health. 2003 Aug;206(4-5):437-45 [12971699] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Toxicology. 2004 May 20;198(1-3):315-28 [15138058] Nature. 1970 Jul 11;227(5254):168-70 [4316953] Proc Natl Acad Sci U S A. 1984 Oct;81(20):6413-7 [6333682] Biochim Biophys Acta. 1989 May 9;988(2):185-220 [2541792] Mutat Res. 1990 Mar;238(2):99-172 [2407950] Methods Enzymol. 1990;192:280-300 [2074793] J Immunol Methods. 1993 Mar 15;160(1):81-8 [7680699] Cell Immunol. 1994 May;155(2):428-35 [8181074] Chem Res Toxicol. 2005 Feb;18(2):154-61 [15720119] Assay Drug Dev Technol. 2005 Apr;3(2):213-25 [15871695] Mutat Res. 2005 Nov 10;587(1-2):1-8 [16202644] Toxicol In Vitro. 2006 Aug;20(5):785-92 [16386874] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Curr Alzheimer Res. 2006 Sep;3(4):377-91 [17017868] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Drug Metab Rev. 1999 Nov;31(4):917-70 [10575555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.10727 ER - TY - JOUR T1 - Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs. AN - 70387802; 18336658 AB - The aim of the present review was to: (i) highlight epidemiological and other studies that have generated important data on the harmful patterns of drinking that increase the risk for chronic diseases, including alcohol dependence, and on the mechanisms by which alcohol produces and, in some instances, may protect against damage; and (ii) discuss a conceptual basis for quantifying risk criteria for alcohol-induced chronic disease based on the quantity, frequency, and pattern of drinking. The relationship between heavy drinking and risk for adverse health conditions such as alcoholic liver disease (ALD), dementia, and alcohol dependence is well known. However, not everyone who drinks chronically develops ALD or dementia, and the major risk factors for disease development and the mechanisms by which this occurs have remained unclear. Large-scale, general population-based studies have provided the evidence by which quantifying the frequency of a pattern of high-risk drinking can be related directly to risk and the severity of alcohol dependence. Cellular and molecular biology studies have identified the major pathways of alcohol metabolism and how genetics and the environment can interact in some individuals to further increase the risk of organ damage. Extant databases should allow scientists and clinicians jointly to develop the framework for quantifying the drinking patterns that increase the risk of alcohol-induced organ pathologies, to develop clinical practice guidelines, such as those used to diagnose other common complex diseases (e.g. diabetes and hypertension), and to propose future studies for refining such guidelines. Attention must be paid to comorbid conditions such as hepatitis B and C infections, HIV, obesity, and environmental exposures other than alcohol. Developing trait and state biomarkers is critical to the process of discovery and to fulfilling the promise of personalized medicine. JF - Journal of gastroenterology and hepatology AU - Li, Ting-Kai AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892-9304, USA. tkli@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - S2 EP - S8 VL - 23 Suppl 1 KW - Index Medicus KW - Biomedical Research -- trends KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Forecasting KW - Child KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Alcohol Drinking -- adverse effects KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70387802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Quantifying+the+risk+for+alcohol-use+and+alcohol-attributable+health+disorders%3A+present+findings+and+future+research+needs.&rft.au=Li%2C+Ting-Kai&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2008-03-01&rft.volume=23+Suppl+1&rft.issue=&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=1440-1746&rft_id=info:doi/10.1111%2Fj.1440-1746.2007.05298.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1746.2007.05298.x ER - TY - JOUR T1 - Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. AN - 70385632; 18204080 AB - Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify the role of carcinogens in both the genetic and epigenetic changes in premalignant tissues and a lack of conclusive information on the link between epigenetic alterations and carcinogenic exposure. In the current study, we investigated whether or not the mechanism of 2-AAF-induced hepatocarcinogenesis consists of both genotoxic (genetic) and non-genotoxic (epigenetic) alterations. Male and female Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 6, 12, 18 or 24 weeks. The levels of DNA adducts obtained from 2-AAF in liver and kidney tissues were assessed by high-performance liquid chromatography combined with electrospray tandem mass spectrometry (HPLC-ES-MS/MS). N-(Deoxyguanosine-8-yl)-2-aminofluorene was the major adduct detected at all time points in both tissues. Global DNA methylation in the livers and kidneys, as determined by an HpaII-based cytosine extension assay and by HPLC-ES-MS/MS, did not change over the 24-week period. In the livers of male rats, there was a progressive decrease of global and long interspersed nucleotide element-1-associated histone H4 lysine 20 trimethylation, as well as hypermethylation of the p16(INK4A) gene. These epigenetic changes were not observed in the livers of female rats or the kidneys of both sexes. Importantly, morphological evidence of formation and progression of neoplastic process was observed in the liver of male rats only. In conclusion, we have demonstrated that exposure of rats to genotoxic hepatocarcinogen 2-AAF, in addition to formation of 2-AAF-specific DNA lesions, resulted in substantial alterations in cellular epigenetic status. JF - Carcinogenesis AU - Bagnyukova, Tetyana V AU - Tryndyak, Volodymyr P AU - Montgomery, Beverly AU - Churchwell, Mona I AU - Karpf, Adam R AU - James, Smitha R AU - Muskhelishvili, Levan AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 638 EP - 646 VL - 29 IS - 3 KW - Carcinogens KW - 0 KW - DNA Adducts KW - Proliferating Cell Nuclear Antigen KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Liver -- metabolism KW - Tandem Mass Spectrometry KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - Chromatography, High Pressure Liquid KW - DNA Adducts -- metabolism KW - Rats KW - Polymerase Chain Reaction KW - Rats, Sprague-Dawley KW - Immunohistochemistry KW - Female KW - Male KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Liver Neoplasms, Experimental -- genetics KW - Precancerous Conditions -- genetics KW - 2-Acetylaminofluorene -- toxicity KW - Liver Neoplasms, Experimental -- metabolism KW - Precancerous Conditions -- chemically induced KW - Carcinogens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - Precancerous Conditions -- metabolism KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70385632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genetic+and+epigenetic+changes+in+rat+preneoplastic+liver+tissue+induced+by+2-acetylaminofluorene.&rft.au=Bagnyukova%2C+Tetyana+V%3BTryndyak%2C+Volodymyr+P%3BMontgomery%2C+Beverly%3BChurchwell%2C+Mona+I%3BKarpf%2C+Adam+R%3BJames%2C+Smitha+R%3BMuskhelishvili%2C+Levan%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgm303 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgm303 ER - TY - JOUR T1 - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. AN - 70384914; 17999989 AB - Chronic inflammation has been hypothesized to increase prostate cancer risk. Prostaglandin-endoperoxide synthase 2 (PTGS2) encodes the proinflammatory cyclooxygenase 2 enzyme believed to be the rate-limiting step in the synthesis of prostaglandins, important mediators of inflammation. We investigated associations between PTGS2 polymorphisms and prostate cancer risk among 2321 prostate cancer cases and 2560 controls in two large case-control studies nested within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Cancer Prevention Study II Nutrition Cohort. Five single nucleotide polymorphisms (SNPs) (rs5277, rs20432, rs4648276, rs5275 and rs689470) were examined in SNP and haplotype analyses (five SNPs in PLCO and four SNPs in the Nutrition Cohort). In PLCO, the Ex10 +837 T>C marker (rs5275) was initially associated with prostate cancer risk (P-trend = 0.02) but became non-significant after adjustment for multiple comparisons (P = 0.08); this SNP showed no association with prostate cancer risk in the Nutrition Cohort (P-trend = 0.54) or in an analysis pooling the two cohorts (P-trend = 0.20). No other SNP was associated with prostate cancer risk in PLCO or the Nutrition Cohort individually or combined. Haplotype analyses suggested an association between PTGS2 variants in PLCO alone (global P = 0.007), but not in the Nutrition Cohort (global P = 0.78) or pooled analysis (global P = 0.18). In conclusion, despite the potential importance of inflammation in prostate carcinogenesis, results from our large study of five PTGS2 SNPs does not support a strong association between PTGS2 variants and prostate cancer risk in non-Hispanic white men. JF - Carcinogenesis AU - Danforth, Kim N AU - Hayes, Richard B AU - Rodriguez, Carmen AU - Yu, Kai AU - Sakoda, Lori C AU - Huang, Wen-Yi AU - Chen, Bingshu E AU - Chen, Jinbo AU - Andriole, Gerald L AU - Calle, Eugenia E AU - Jacobs, Eric J AU - Chu, Lisa W AU - Figueroa, Jonine D AU - Yeager, Meredith AU - Platz, Elizabeth A AU - Michaud, Dominique S AU - Chanock, Stephen J AU - Thun, Michael J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. danfortk@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 568 EP - 572 VL - 29 IS - 3 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 2 -- genetics KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70384914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphic+variants+in+PTGS2+and+prostate+cancer+risk%3A+results+from+two+large+nested+case-control+studies.&rft.au=Danforth%2C+Kim+N%3BHayes%2C+Richard+B%3BRodriguez%2C+Carmen%3BYu%2C+Kai%3BSakoda%2C+Lori+C%3BHuang%2C+Wen-Yi%3BChen%2C+Bingshu+E%3BChen%2C+Jinbo%3BAndriole%2C+Gerald+L%3BCalle%2C+Eugenia+E%3BJacobs%2C+Eric+J%3BChu%2C+Lisa+W%3BFigueroa%2C+Jonine+D%3BYeager%2C+Meredith%3BPlatz%2C+Elizabeth+A%3BMichaud%2C+Dominique+S%3BChanock%2C+Stephen+J%3BThun%2C+Michael+J%3BHsing%2C+Ann+W&rft.aulast=Danforth&rft.aufirst=Kim&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analytical bias of cross-reactive polyclonal antibodies for environmental immunoassays of Alternaria alternata. AN - 70382832; 18036643 AB - Alternaria alternata is recognized as an important aeroallergen indoors and outdoors, and exposure to the fungus has been identified as a risk factor for asthma. Two recent publications concluded that 95% to 99% of American homes contained detectable amounts of Alternaria antigens when analyzed with a polyclonal antibody (pAb)-based ELISA. We investigated the cross-reactivity of the commercially available pAbs that were used in those studies. Reactivity to 24 fungal species commonly found in indoor environments was analyzed by inhibition ELISA by using solid-phase A alternata antigen. The pAbs were also tested by immunoblotting and halogen immunoassay for a subgroup of fungi. Spores of 7 fungi including species of Alternaria, Ulocladium, Stemphylium, Epicoccum, Drechslera, and Exserohilum strongly inhibited the binding of the pAbs when tested by ELISA. Six other fungi reacted in the ELISA at a lower level, and 11 fungal species including several Penicillium, Aspergillus, Fusarium, and Cladosporium species failed to show inhibition. The immunoblots and the halogen immunoassay staining confirmed the cross-reactivity patterns of the ELISA. The pAbs against A alternata were found to cross-react broadly with related and nonrelated fungi. The prevalence data previously reported for A alternata should be considered to be fungal-reactive rather than A alternata-specific. JF - The Journal of allergy and clinical immunology AU - Schmechel, Detlef AU - Green, Brett J AU - Blachere, Francoise M AU - Janotka, Erika AU - Beezhold, Donald H AD - Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. DSchmechel@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 763 EP - 768 VL - 121 IS - 3 KW - Antibodies, Fungal KW - 0 KW - Antigens, Fungal KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Antibody Specificity KW - Air Pollution, Indoor KW - Cross Reactions KW - Immunoassay -- methods KW - Antigens, Fungal -- analysis KW - Antibodies, Fungal -- immunology KW - Alternaria -- isolation & purification KW - Air Microbiology KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70382832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Analytical+bias+of+cross-reactive+polyclonal+antibodies+for+environmental+immunoassays+of+Alternaria+alternata.&rft.au=Schmechel%2C+Detlef%3BGreen%2C+Brett+J%3BBlachere%2C+Francoise+M%3BJanotka%2C+Erika%3BBeezhold%2C+Donald+H&rft.aulast=Schmechel&rft.aufirst=Detlef&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-13 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis. AN - 70367294; 18175291 AB - To estimate the extent of reporting to FDA through statin-associated rhabdomyolysis data. Data included incidence rates (IRs) of hospitalized rhabdomyolysis among statin users from a population-based study, and comparable reported AERS cases and national estimates of statin use from an AERS analysis. Using IRs, national estimates of statin use and average days supply per prescription, we estimated the number of US statin-associated cases of hospitalized rhabdomyolysis. We compared this estimate to the observed number of cases reported to FDA to evaluate the extent of reporting. We repeated this method for atorvastatin, cerivastatin, pravastatin, and simvastatin and statin combinations. We performed sensitivity analyses to check for biases such as misclassification of statin use and cohort selection bias. We evaluated potential time-dependent cerivastatin reporting by a "Dear Health Care Provider (DHCP)" letter. The estimated extent of reporting to FDA varied by statin (atorvastatin, 5.0%; cerivastatin, 31.2%; simvastatin, 14.2%; all four combined, 17.7%; and non-cerivastatin statins combined, 9.9%). No pravastatin-associated cohort cases occurred. Across a reasonable value range, sensitivity analyses did not significantly alter the results; overall the cohort was similar to national statin-users. There was a large increase in AERS reports after the cerivastatin DHCP letter and the estimated extent of reporting increased from 14.8 to 35.0%. The extent of reporting of adverse events to FDA varied by statin and may be influenced by publicity. For statins-associated rhabdomyolysis, the estimated extent of reporting appears to range from 5 to 30% but in the absence of stimulated reporting appears to be 5-15%. Copyright 2008 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - McAdams, Mara AU - Staffa, Judy AU - Dal Pan, Gerald AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. mara.mcadams@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 229 EP - 239 VL - 17 IS - 3 KW - Heptanoic Acids KW - 0 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyridines KW - Pyrroles KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Simvastatin KW - AGG2FN16EV KW - cerivastatin KW - AM91H2KS67 KW - Pravastatin KW - KXO2KT9N0G KW - Index Medicus KW - Pyrroles -- adverse effects KW - Simvastatin -- adverse effects KW - United States Food and Drug Administration -- statistics & numerical data KW - Humans KW - Retrospective Studies KW - Aged KW - Child KW - Heptanoic Acids -- adverse effects KW - Child, Preschool KW - Infant KW - Pravastatin -- adverse effects KW - Hospitalization KW - Adult KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Pyridines -- adverse effects KW - Male KW - Female KW - Rhabdomyolysis -- epidemiology KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Rhabdomyolysis -- chemically induced KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70367294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Estimating+the+extent+of+reporting+to+FDA%3A+a+case+study+of+statin-associated+rhabdomyolysis.&rft.au=McAdams%2C+Mara%3BStaffa%2C+Judy%3BDal+Pan%2C+Gerald&rft.aulast=McAdams&rft.aufirst=Mara&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1535 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1535 ER - TY - JOUR T1 - An evaluation of impact wrench vibration emissions and test methods. AN - 70367071; 18212244 AB - In the interest of providing more effective evaluations of impact wrench vibration exposures and the development of improved methods for measuring vibration emissions produced by these tools, this study focused on three variables: acceleration measured at the tool surface, vibration exposure duration per test trial, and the amount of torque required to unseat the nuts following a test trial. For this evaluation, six experienced male impact wrench operators used three samples each of five impact wrench models (four pneumatic models and one battery-powered model) in a simulated work task. The test setup and procedures were based on those provided by an International Organization for Standardization (ISO) Technical Committee overseeing the revision of ISO 8662-7. The work task involved the seating of 10 nuts onto 10 bolts mounted on steel plates. The results indicate that acceleration magnitudes vary not only by tool type but also by individual tools within a type. Thus, evaluators are cautioned against drawing conclusions based on small numbers of tools and/or tool operators. Appropriate sample sizes are suggested. It was further noted that evaluators could draw different conclusions if tool assessments are based on ISO-weighted acceleration as opposed to unweighted acceleration. As expected, vibration exposure durations varied by tool type and by test subject; duration means varied more for study participants than they did for tool types. For the 12 pneumatic tools evaluated in this study, torque varied directly with tool handle acceleration. Therefore, in order to reduce vibration exposure, tools should be selected and adjusted so that they produce no more than the needed torque for the task at hand. JF - The Annals of occupational hygiene AU - McDowell, Thomas W AU - Dong, R G AU - Xu, X AU - Welcome, D E AU - Warren, C AD - National Institute for Occupational Safety and Health (NIOSH), NIOSH Health Effects Lab, 1095 Willowdale Road, Morgantown, WV 26505, USA. tmcdowell@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 125 EP - 138 VL - 52 IS - 2 KW - Index Medicus KW - Humans KW - Torque KW - Equipment Design -- standards KW - Algorithms KW - Predictive Value of Tests KW - Equipment Safety -- standards KW - Male KW - Hand-Arm Vibration Syndrome -- prevention & control KW - Occupational Exposure -- statistics & numerical data KW - Hand -- physiology KW - Occupational Exposure -- adverse effects KW - Vibration -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70367071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=An+evaluation+of+impact+wrench+vibration+emissions+and+test+methods.&rft.au=McDowell%2C+Thomas+W%3BDong%2C+R+G%3BXu%2C+X%3BWelcome%2C+D+E%3BWarren%2C+C&rft.aulast=McDowell&rft.aufirst=Thomas&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem064 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem064 ER - TY - JOUR T1 - Toward better vaccine safety data and safer vaccination. AN - 70364537; 18310214 JF - Pediatrics AU - Braun, M Miles AD - Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-220, 1401 Rockville Pike, Rockville, MD 20852, USA. miles.braun@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 625 EP - 626 VL - 121 IS - 3 KW - Measles-Mumps-Rubella Vaccine KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Infant KW - Centers for Disease Control and Prevention (U.S.) KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Immunization Schedule KW - Male KW - Female KW - Risk Assessment KW - Child, Preschool KW - Vaccination -- methods KW - Purpura, Thrombocytopenic -- epidemiology KW - Measles-Mumps-Rubella Vaccine -- adverse effects KW - Vaccination -- adverse effects KW - Purpura, Thrombocytopenic -- etiology KW - Measles-Mumps-Rubella Vaccine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70364537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Toward+better+vaccine+safety+data+and+safer+vaccination.&rft.au=Braun%2C+M+Miles&rft.aulast=Braun&rft.aufirst=M&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-3846 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pediatrics. 2008 Mar;121(3):e687-92 [18310189] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-3846 ER - TY - JOUR T1 - Field measurement of diesel particulate matter emissions. AN - 70363757; 18281294 AB - A primary means to reduce environmental levels of diesel particulate matter (DPM) exposure to miners is to reduce the amount of DPM emission from the engine. A quick and economic method to estimate engine particulate emission levels has been developed. The method relies on the measurement of pressure increase across a filter element that is briefly used to collect a DPM sample directly from the engine exhaust. The method has been refined with the inclusion of an annular aqueous denuder to the tube which permits dry filter samples to be obtained without addition of dilution air. Tailpipe filter samples may then be directly collected in hot and water-supersaturated exhaust gas flows from water bath-cooled coal mine engines without the need for dilution air. Measurement of a differential pressure (DP) increase with time has been related to the mass of elemental carbon (EC) on the filter. Results for laboratory and field measurements of the method showed agreement between DP increase and EC collected on the filter with R(2) values >0.86. The relative standard deviation from replicate samples of DP and EC was 0.16 and 0.11, respectively. The method may also have applications beyond mining, where qualitative evaluation of engine emissions is desirable to determine if engine or control technology maintenance may be required. JF - The Annals of occupational hygiene AU - Volkwein, Jon C AU - Mischler, Steven E AU - Davies, Brian AU - Ellis, Clive AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, Pittsburgh, PA 15236, USA. jdv1@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 99 EP - 105 VL - 52 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Gasoline KW - Particulate Matter KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Humans KW - Carbon -- adverse effects KW - Equipment Design -- standards KW - Mining KW - Carbon -- analysis KW - Environmental Monitoring -- statistics & numerical data KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Gasoline -- adverse effects KW - Air Pollutants, Occupational -- adverse effects KW - Particulate Matter -- adverse effects KW - Particulate Matter -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70363757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Field+measurement+of+diesel+particulate+matter+emissions.&rft.au=Volkwein%2C+Jon+C%3BMischler%2C+Steven+E%3BDavies%2C+Brian%3BEllis%2C+Clive&rft.aulast=Volkwein&rft.aufirst=Jon&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem069 ER - TY - JOUR T1 - Monitoring microbial populations on wide-body commercial passenger aircraft. AN - 70362978; 18316352 AB - Although exposure to bacteria has been assessed in cabin air previously, minimal numbers of samples have been collected in-flight. The purpose of this research was to comprehensively characterize bacterial concentrations in the aircraft cabin. Twelve randomly selected flights were sampled on Boeing-767 aircraft, each with a flight duration between 4.5 and 6.5 h. N-6 impactors were used to collect sequential, triplicate air samples in the front and rear of coach class during six sampling intervals throughout each flight: boarding, mid-climb, early cruise, mid-cruise, late cruise and deplaning. Comparison air samples were also collected inside and outside the airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log-transformed bacterial concentrations. A total of 513 airborne culturable bacterial samples were collected. During flight (mid-climb and cruise intervals), a model-adjusted geometric mean (GM) of 136 total colony-forming units per cubic meter of air sampled (CFU x m(-3)) and geometric standard deviation of 2.1 were observed. Bacterial concentrations were highest during the boarding (GM 290 CFU x m(-3)) and deplaning (GM 549 CFU x m(-3)) processes. Total bacterial concentrations observed during flight were significantly lower than GMs for boarding and deplaning (P values <0.0001-0.021) in the modeled results. Our findings highlight the fact that aerobiological concentrations can be dynamic and underscore the importance of appropriate sample size and design. The genera analysis indicates that passenger activity and high occupant density contribute to airborne bacterial generation. Overall, our research demonstrates that the bacteria recovered on observed flights were either common skin-surface organisms (primarily gram-positive cocci) or organisms common in dust and outdoor air. JF - The Annals of occupational hygiene AU - McKernan, Lauralynn Taylor AU - Wallingford, Kenneth M AU - Hein, Misty J AU - Burge, Harriet AU - Rogers, Christine A AU - Herrick, Robert AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. lmckernan@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 139 EP - 149 VL - 52 IS - 2 KW - Index Medicus KW - Micrococcus luteus -- isolation & purification KW - Colony Count, Microbial -- methods KW - Humans KW - Staphylococcus -- isolation & purification KW - Bacillus -- isolation & purification KW - Rhodococcus -- isolation & purification KW - Male KW - Female KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Aircraft KW - Environmental Monitoring -- methods KW - Air Microbiology -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Monitoring+microbial+populations+on+wide-body+commercial+passenger+aircraft.&rft.au=McKernan%2C+Lauralynn+Taylor%3BWallingford%2C+Kenneth+M%3BHein%2C+Misty+J%3BBurge%2C+Harriet%3BRogers%2C+Christine+A%3BHerrick%2C+Robert&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem068 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem068 ER - TY - JOUR T1 - Genome-wide association for methamphetamine dependence: convergent results from 2 samples. AN - 70362818; 18316681 AB - We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence. To find "methamphetamine dependence" genes identified by each of 2 genome-wide association (GWA) studies of independent samples of methamphetamine-dependent individuals and matched controls. Replicated GWA results in each of 2 case-control studies. Japan and Taiwan. Individuals with methamphetamine dependence and matched control subjects free from psychiatric, substance abuse, or substance dependence diagnoses (N = 580). "Methamphetamine dependence" genes that were reproducibly identified by clusters of nominally positive single-nucleotide polymorphisms (SNPs) in both samples in ways that were unlikely to represent chance observations, based on Monte Carlo simulations that corrected for multiple comparisons, and subsets of "methamphetamine dependence" genes that were also identified by GWA studies of dependence on other addictive substances, success in quitting smoking, and memory. Genes identified by clustered nominally positive SNPs from both samples were unlikely to represent chance observations (Monte Carlo P < .00001). Variants in these "methamphetamine dependence" genes are likely to alter cell adhesion, enzymatic functions, transcription, cell structure, and DNA, RNA, and/or protein handling or modification. Cell adhesion genes CSMD1 and CDH13 displayed the largest numbers of clustered nominally positive SNPs. "Methamphetamine dependence" genes overlapped, to extents much greater than chance, with genes identified in GWA studies of dependence on other addictive substances, success in quitting smoking, and memory (Monte Carlo P range < .04 to < .00001). These data support polygenic contributions to methamphetamine dependence from genes that include those whose variants contribute to dependence on several addictive substances, success in quitting smoking, and mnemonic processes. JF - Archives of general psychiatry AU - Uhl, George R AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Johnson, Catherine AU - Walther, Donna AU - Komiyama, Tokutaro AU - Harano, Mutsuo AU - Sekine, Yoshimoto AU - Inada, Toshiya AU - Ozaki, Norio AU - Iyo, Masaomi AU - Iwata, Nakao AU - Yamada, Mitsuhiko AU - Sora, Ichiro AU - Chen, Chih-Ken AU - Liu, Hsing-Cheng AU - Ujike, Hiroshi AU - Lin, Shih-Ku AD - Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 345 EP - 355 VL - 65 IS - 3 KW - CSMD1 protein, human KW - 0 KW - Cadherins KW - H-cadherin KW - Membrane Proteins KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Adult KW - Case-Control Studies KW - Membrane Proteins -- genetics KW - Genome KW - Cadherins -- genetics KW - Male KW - Female KW - Amphetamine-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Genome-wide+association+for+methamphetamine+dependence%3A+convergent+results+from+2+samples.&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BJohnson%2C+Catherine%3BWalther%2C+Donna%3BKomiyama%2C+Tokutaro%3BHarano%2C+Mutsuo%3BSekine%2C+Yoshimoto%3BInada%2C+Toshiya%3BOzaki%2C+Norio%3BIyo%2C+Masaomi%3BIwata%2C+Nakao%3BYamada%2C+Mitsuhiko%3BSora%2C+Ichiro%3BChen%2C+Chih-Ken%3BLiu%2C+Hsing-Cheng%3BUjike%2C+Hiroshi%3BLin%2C+Shih-Ku&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-03-01&rft.volume=65&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=1538-3636&rft_id=info:doi/10.1001%2Farchpsyc.65.3.345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archpsyc.65.3.345 ER - TY - JOUR T1 - U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. AN - 70361752; 18316547 AB - To describe the Food and Drug Administration review and marketing approval considerations for panitumumab (Vectibix) for the third-line treatment of patients with epidermal growth factor receptor-expressing metastatic colorectal carcinoma. Food and Drug Administration reviewed a single, open-label, multicenter trial in which 463 patients with epidermal growth factor receptor-expressing metastatic colorectal cancer who had progressed on or following treatment with a regimen containing a fluoropyrimidine, oxaliplatin, and irinotecan were randomized (1:1) to receive best supportive care (BSC) with or without panitumumab (6 mg/kg every other week) administered until disease progression or intolerable toxicity. Progression and response were confirmed by an independent review committee masked to treatment assignment. At progression, patients in the BSC-alone arm were eligible to receive panitumumab. Although median progression-free survival (PFS) was similar in both treatment arms ( approximately 8 weeks), the mean PFS was approximately 50% longer among patients receiving panitumumab than among those receiving BSC alone (96 versus 60 days, respectively) and the objective response rate in patients receiving panitumumab was 8%. However, no difference in overall survival was shown between the two study arms. Panitumumab received accelerated approval based on improvement in PFS and an independently confirmed response rate of 8%, similar to that observed with other active agents at this advanced stage of disease. Confirmation of clinical benefit will be required for full approval. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Giusti, Ruthann M AU - Shastri, Kaushikkumar AU - Pilaro, Anne M AU - Fuchs, Chana AU - Cordoba-Rodriguez, Ruth AU - Koti, Kallappa AU - Rothmann, Mark AU - Men, Angela Yuxin AU - Zhao, Hong AU - Hughes, Monica AU - Keegan, Patricia AU - Weiss, Karen D AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0004, USA. ruthann.giusti@fda.hhs.gov Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1296 EP - 1302 VL - 14 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - irinotecan KW - 0H43101T0J KW - panitumumab KW - 6A901E312A KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - United States KW - Disease-Free Survival KW - Organoplatinum Compounds -- administration & dosage KW - Lymphatic Metastasis KW - Humans KW - Disease Progression KW - Aged KW - Antibodies, Monoclonal -- administration & dosage KW - Camptothecin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - United States Food and Drug Administration KW - Survival Rate KW - Adult KW - Camptothecin -- analogs & derivatives KW - Middle Aged KW - Chemotherapy, Adjuvant KW - Male KW - Liver Neoplasms -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- metabolism KW - Lung Neoplasms -- secondary KW - Liver Neoplasms -- drug therapy KW - Drug Approval KW - Lung Neoplasms -- drug therapy KW - Liver Neoplasms -- secondary KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70361752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=U.S.+Food+and+Drug+Administration+approval%3A+panitumumab+for+epidermal+growth+factor+receptor-expressing+metastatic+colorectal+carcinoma+with+progression+following+fluoropyrimidine-%2C+oxaliplatin-%2C+and+irinotecan-containing+chemotherapy+regimens.&rft.au=Giusti%2C+Ruthann+M%3BShastri%2C+Kaushikkumar%3BPilaro%2C+Anne+M%3BFuchs%2C+Chana%3BCordoba-Rodriguez%2C+Ruth%3BKoti%2C+Kallappa%3BRothmann%2C+Mark%3BMen%2C+Angela+Yuxin%3BZhao%2C+Hong%3BHughes%2C+Monica%3BKeegan%2C+Patricia%3BWeiss%2C+Karen+D%3BPazdur%2C+Richard&rft.aulast=Giusti&rft.aufirst=Ruthann&rft.date=2008-03-01&rft.volume=14&rft.issue=5&rft.spage=1296&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1354 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-23 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1354 ER - TY - JOUR T1 - Improving pediatric dosing through pediatric initiatives: what we have learned. AN - 70361616; 18310202 AB - The goal was to review the impact of pediatric drug studies, as measured by the improvement in pediatric dosing and other pertinent information captured in the drug labeling. We reviewed the pediatric studies for 108 products submitted (July 1998 through October 2005) in response to a Food and Drug Administration written request for pediatric studies, and the subsequent labeling changes. We analyzed the dosing modifications and focused on drug clearance as an important parameter influencing pediatric dosing. The first 108 drugs with new or revised pediatric labeling changes had dosing changes or pharmacokinetic information (n = 23), new safety information (n = 34), information concerning lack of efficacy (n = 19), new pediatric formulations (n = 12), and extended age limits (n = 77). A product might have had > or = 1 labeling change. We selected specific examples (n = 16) that illustrate significant differences in pediatric pharmacokinetics. Critical changes in drug labeling for pediatric patients illustrate that unique pediatric dosing often is necessary, reflecting growth and maturational stages of pediatric patients. These changes provide evidence that pediatric dosing should not be determined by simply applying weight-based calculations to the adult dose. Drug clearance is highly variable in the pediatric population and is not readily predictable on the basis of adult information. JF - Pediatrics AU - Rodriguez, William AU - Selen, Arzu AU - Avant, Debbie AU - Chaurasia, Chandra AU - Crescenzi, Terrie AU - Gieser, Gerlie AU - Di Giacinto, Jennifer AU - Huang, Shiew-Mei AU - Lee, Peter AU - Mathis, Lisa AU - Murphy, Dianne AU - Murphy, Shirley AU - Roberts, Rosemary AU - Sachs, Hari Cheryl AU - Suarez, Sandra AU - Tandon, Veneeta AU - Uppoor, Ramana S AD - Food and Drug Administration, 5600 Fisher Lane, Parklawn Building, Room 13B-45, Rockville, MD 20850, USA. william.rodriguez@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 530 EP - 539 VL - 121 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Administration, Oral KW - Age Factors KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Body Surface Area KW - Child KW - Biological Availability KW - Child, Preschool KW - Registries KW - Infant KW - Drug Evaluation KW - United States Food and Drug Administration KW - Half-Life KW - Forecasting KW - Maximum Tolerated Dose KW - Adolescent KW - Male KW - Female KW - Pharmaceutical Preparations -- administration & dosage KW - Evaluation Studies as Topic KW - Drug Labeling -- legislation & jurisprudence KW - Pediatrics -- standards KW - Drug Labeling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70361616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Improving+pediatric+dosing+through+pediatric+initiatives%3A+what+we+have+learned.&rft.au=Rodriguez%2C+William%3BSelen%2C+Arzu%3BAvant%2C+Debbie%3BChaurasia%2C+Chandra%3BCrescenzi%2C+Terrie%3BGieser%2C+Gerlie%3BDi+Giacinto%2C+Jennifer%3BHuang%2C+Shiew-Mei%3BLee%2C+Peter%3BMathis%2C+Lisa%3BMurphy%2C+Dianne%3BMurphy%2C+Shirley%3BRoberts%2C+Rosemary%3BSachs%2C+Hari+Cheryl%3BSuarez%2C+Sandra%3BTandon%2C+Veneeta%3BUppoor%2C+Ramana+S&rft.aulast=Rodriguez&rft.aufirst=William&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-1529 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-1529 ER - TY - JOUR T1 - Evaluation of the rationale for concurrent use of N95 filtering facepiece respirators with loose-fitting powered air-purifying respirators during aerosol-generating medical procedures. AN - 70353718; 18313516 AB - The concurrent use of N95 filtering facepiece respirators with powered air-purifying respirators during aerosol-generating medical procedures in patients with severe respiratory pathogens has been promoted as offering additional protection against infectious agents. The purpose of this article is to examine the impact of this additional respiratory equipment upon protection and personal performance. The presumed additive protective effect of an N95 filtering facepiece respirator used concurrently with a powered air-purifying respirator has not been subjected to rigorous scientific investigation. The burden imposed by additional respiratory protective equipment should not be discounted, and the potentially minor contribution to protection may be offset by the negative impact on personal performance. Novel uses of protective equipment occasionally are spawned during crisis situations, but their generalized applicability to healthcare workers should ultimately be evidence-based. JF - American journal of infection control AU - Roberge, Raymond J AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA. dtn0@cdc.gov. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 135 EP - 141 VL - 36 IS - 2 KW - Aerosols KW - 0 KW - Index Medicus KW - Humans KW - Respiratory Protective Devices KW - Occupational Exposure -- prevention & control KW - Inhalation Exposure -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70353718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Evaluation+of+the+rationale+for+concurrent+use+of+N95+filtering+facepiece+respirators+with+loose-fitting+powered+air-purifying+respirators+during+aerosol-generating+medical+procedures.&rft.au=Roberge%2C+Raymond+J&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2008-03-01&rft.volume=36&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=1527-3296&rft_id=info:doi/10.1016%2Fj.ajic.2007.04.284 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-18 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajic.2007.04.284 ER - TY - JOUR T1 - Migration of fluorochemical paper additives from food-contact paper into foods and food simulants. AN - 70349993; 18311629 AB - Fluorochemical-treated paper was tested to determine the amount of migration that occurs into foods and food-simulating liquids and the characteristics of the migration. Migration characteristics of fluorochemicals from paper were examined in Miglyol, butter, water, vinegar, water-ethanol solutions, emulsions and pure oil containing small amounts of emulsifiers. Additionally, microwave popcorn and chocolate spread were used to investigate migration. Results indicate that fluorochemicals paper additives do migrate to food during actual package use. For example, we found that microwave popcorn contained 3.2 fluorochemical mg kg(-1) popcorn after popping and butter contained 0.1 mg kg(-1) after 40 days at 4 degrees C. Tests also indicate that common food-simulating liquids for migration testing and package material evaluation might not provide an accurate indication of the amount of fluorochemical that actually migrates to food. Tests show that oil containing small amounts of an emulsifier can significantly enhance migration of a fluorochemical from paper. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Begley, T H AU - Hsu, W AU - Noonan, G AU - Diachenko, G AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. timothy.begley@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 384 EP - 390 VL - 25 IS - 3 KW - Fluorocarbons KW - 0 KW - Index Medicus KW - Consumer Product Safety KW - Food Technology KW - Adsorption KW - Paper KW - Fluorocarbons -- chemistry KW - Fluorocarbons -- analysis KW - Food Contamination -- analysis KW - Food Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70349993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Migration+of+fluorochemical+paper+additives+from+food-contact+paper+into+foods+and+food+simulants.&rft.au=Begley%2C+T+H%3BHsu%2C+W%3BNoonan%2C+G%3BDiachenko%2C+G&rft.aulast=Begley&rft.aufirst=T&rft.date=2008-03-01&rft.volume=25&rft.issue=3&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F02652030701513784 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02652030701513784 ER - TY - JOUR T1 - Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein. AN - 70338669; 18230369 AB - Human monoclonal antibodies derived from B cells of HCV-infected individuals provide information on the immune response to native HCV envelope proteins as they are recognized during infection. Monoclonal antibodies have been useful in the determination of the function and structure of specific immunogenic domains of proteins and should also be useful for the structure/function characterization of HCV E1 and E2 envelope glycoproteins. The HCV E2 envelope glycoprotein has at least three immunodistinctive conformation domains, designated A, B, and C. Conformational epitopes within domain B and C are neutralizing antibody targets on HCV pseudoparticles as well as from infectious cell culture virus. In this study, a combination of differential surface modification and mass spectrometric limited proteolysis followed by alanine mutagenesis was used to provide insight into potential conformational changes within the E2 protein upon antibody binding. The arginine guanidine groups in the E2 protein were modified with CHD in both the affinity bound and free states followed by mass spectrometric analysis, and the regions showing protection upon antibody binding were identified. This protection can arise by direct contact between the residues and the monoclonal antibody, or by antibody-induced conformational changes. Based on the mass spectrometric data, site-directed mutagenesis experiments were performed which clearly identified additional amino acid residues on E2 distant from the site of antibody interaction, whose change to alanine inhibited antibody recognition by inducing conformational changes within the E2 protein. JF - Biochimica et biophysica acta AU - Iacob, Roxana E AU - Keck, Zhenyong AU - Olson, Oakley AU - Foung, Steven K H AU - Tomer, Kenneth B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 530 EP - 542 VL - 1784 IS - 3 SN - 0006-3002, 0006-3002 KW - Antibodies, Monoclonal KW - 0 KW - Antigen-Antibody Complex KW - Hepatitis C Antibodies KW - Immunodominant Epitopes KW - Viral Envelope Proteins KW - glycoprotein E2, Hepatitis C virus KW - 157184-61-7 KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Arginine -- genetics KW - Arginine -- chemistry KW - Humans KW - Molecular Sequence Data KW - Hepatitis C Antibodies -- immunology KW - Amino Acid Sequence KW - Epitope Mapping KW - Protein Conformation KW - Antibodies, Monoclonal -- immunology KW - Immunodominant Epitopes -- immunology KW - Antigen-Antibody Reactions KW - Antigen-Antibody Complex -- immunology KW - Viral Envelope Proteins -- immunology KW - Viral Envelope Proteins -- chemistry KW - Immunodominant Epitopes -- genetics KW - Immunodominant Epitopes -- chemistry KW - Antigen-Antibody Complex -- chemistry KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70338669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Structural+elucidation+of+critical+residues+involved+in+binding+of+human+monoclonal+antibodies+to+hepatitis+C+virus+E2+envelope+glycoprotein.&rft.au=Iacob%2C+Roxana+E%3BKeck%2C+Zhenyong%3BOlson%2C+Oakley%3BFoung%2C+Steven+K+H%3BTomer%2C+Kenneth+B&rft.aulast=Iacob&rft.aufirst=Roxana&rft.date=2008-03-01&rft.volume=1784&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2007.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biotechnol. 2002 Jan;20(1):49-62 [11876299] J Virol. 2002 Aug;76(15):7672-82 [12097581] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] Nature. 2003 Mar 20;422(6929):307-12 [12646921] Virology. 2003 Mar 15;307(2):255-65 [12667795] Biochimie. 2003 Mar-Apr;85(3-4):295-301 [12770768] J Biol Chem. 2003 Nov 7;278(45):44385-92 [12882983] J Virol. 2004 Mar;78(6):2994-3002 [14990718] J Virol. 2004 Jul;78(13):7257-63 [15194801] J Virol. 2004 Sep;78(17):9224-32 [15308717] J Gen Virol. 2004 Nov;85(Pt 11):3173-88 [15483230] Annu Rev Microbiol. 2004;58:391-424 [15487943] Biomed Mass Spectrom. 1984 Nov;11(11):601 [6525415] Science. 1989 Oct 6;246(4926):64-71 [2675315] Anal Chem. 1990 May 1;62(9):882-99 [2194402] Proc Natl Acad Sci U S A. 1990 Dec;87(24):9848-52 [1702219] Anal Biochem. 1991 Jul;196(1):120-5 [1888025] Anal Chem. 1991 Dec 15;63(24):1193A-1203A [1789447] Virology. 1992 Apr;187(2):573-90 [1312269] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5630-4 [1608973] J Virol. 1993 May;67(5):2747-55 [8474172] Bioconjug Chem. 1994 Nov-Dec;5(6):583-90 [7873661] Nature. 1995 May 25;375(6529):291-8 [7753193] J Immunol. 1996 Jul 1;157(1):198-206 [8683115] J Virol. 1997 Feb;71(2):1443-52 [8995670] Virology. 1997 Apr 28;231(1):119-29 [9143310] J Virol. 1997 Nov;71(11):8377-84 [9343193] J Cell Biol. 1997 Nov 3;139(3):613-23 [9348279] J Viral Hepat. 1997;4(6):421-2 [9430363] Nature. 1998 Jun 18;393(6686):705-11 [9641684] Virology. 1998 Sep 15;249(1):32-41 [9740774] J Biol Chem. 1998 Nov 27;273(48):32088-95 [9822684] J Virol. 2005 Jan;79(2):1252-61 [15613352] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] J Virol. 2005 Apr;79(8):4870-6 [15795272] Nature. 2005 Aug 18;436(7053):946-52 [16107834] J Virol. 2005 Nov;79(21):13199-208 [16227243] Mass Spectrom Rev. 2006 Jul-Aug;25(4):663-82 [16477643] J Virol. 2006 Sep;80(17):8695-704 [16912317] Hepatology. 2006 Nov;44(5):1355-61 [17058236] J Am Soc Mass Spectrom. 2006 Nov;17(11):1560-9 [16875837] J Virol. 2007 Jan;81(2):1043-7 [17079294] J Virol. 2007 Feb;81(4):2031-8 [17108020] Novartis Found Symp. 2006;277:57-65; discussion 65-73, 251-3 [17319154] Science. 2000 Apr 14;288(5464):339-44 [10764648] J Immunol. 2000 Apr 15;164(8):4156-61 [10754311] J Virol. 2007 Aug;81(15):8101-11 [17522218] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5802-6 [10811876] Proteins. 2000 Aug 15;40(3):355-66 [10861927] J Gen Virol. 2000 Oct;81(Pt 10):2451-9 [10993933] J Virol. 2000 Nov;74(22):10407-16 [11044085] Anal Chem. 2001 Aug 15;73(16):4012-9 [11534730] Trends Biochem Sci. 2001 Nov;26(11):687-9 [11701329] Immunity. 2001 Dec;15(6):883-95 [11754811] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbapap.2007.12.015 ER - TY - JOUR T1 - Bronchiolitis obliterans in workers exposed to flavoring chemicals. AN - 70332218; 18303424 AB - Medical and environmental surveys at microwave popcorn plants and flavoring production plants have revealed a risk for bronchiolitis obliterans in workers exposed to flavoring chemicals. Workers in other food industries may also be at risk. This review summarizes the available information on disease characteristics and natural history and provides information on workplace characteristics associated with disease development. Investigations carried out in flavoring plants in California have identified severely affected current and former workers in four plants. Affected former workers have also been identified at a plant in the Netherlands that manufactured diacetyl, a predominant chemical in butter flavorings which has been implicated as a causal agent for lung disease in microwave popcorn workers. Workers who manufacture or use flavorings can be subjected to repeated intense exposures to flavoring chemicals. Affected workers can progress to severe fixed airways obstruction in as little as 7 months. Since medical treatment is generally ineffective, early identification of affected workers and removal from further exposure, along with control of exposures to protect coworkers, are essential to minimize this hazard. JF - Current opinion in pulmonary medicine AU - Kanwal, Richard AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. rkanwal@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 141 EP - 146 VL - 14 IS - 2 SN - 1070-5287, 1070-5287 KW - Flavoring Agents KW - 0 KW - Index Medicus KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Bronchiolitis Obliterans -- chemically induced KW - Flavoring Agents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Bronchiolitis Obliterans -- epidemiology KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pulmonary+medicine&rft.atitle=Bronchiolitis+obliterans+in+workers+exposed+to+flavoring+chemicals.&rft.au=Kanwal%2C+Richard&rft.aulast=Kanwal&rft.aufirst=Richard&rft.date=2008-03-01&rft.volume=14&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pulmonary+medicine&rft.issn=10705287&rft_id=info:doi/10.1097%2FMCP.0b013e3282f52478 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MCP.0b013e3282f52478 ER - TY - JOUR T1 - Effect of surgical masks worn concurrently over N95 filtering facepiece respirators: extended service life versus increased user burden. AN - 70319000; 18287908 AB - Growing concern over the availability of Respiratory protective devices (eg, filtering facepiece Respirators), in the face of the probable extreme demand brought on by a pandemic influenza, has prompted the suggestion that useful life of N95 filtering facepiece Respirator can be extended by the concurrent use of a surgical mask as an outer protective barrier over the Respirator. Personal protective equipment generally places a strain on the user, and the detrimental physiological and psychological burdens normally imposed by Respirator use could be magnified by the addition of an extra layer of protection such as a surgical mask. The issue of this potentially increased burden of the concurrent use of a surgical facemask with an N95 filtering facepiece Respirator is investigated to afford users the necessary information to make informed decisions Regarding the use of this Respiratory personal protective equipment in the face of large-scale outbreaks of Respiratory pathogens. JF - Journal of public health management and practice : JPHMP AU - Roberge, Raymond J AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, PA 15236, USA. dtn0@cdc.gov PY - 2008 SP - E19 EP - E26 VL - 14 IS - 2 KW - Health technology assessment KW - Equipment Design KW - Inhalation Exposure -- prevention & control KW - Risk Factors KW - Humans KW - Filtration -- instrumentation KW - Occupational Diseases -- prevention & control KW - Infection Control -- instrumentation KW - Respiratory Tract Diseases -- prevention & control KW - Respiratory Protective Devices KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - Masks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70319000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+public+health+management+and+practice+%3A+JPHMP&rft.atitle=Effect+of+surgical+masks+worn+concurrently+over+N95+filtering+facepiece+respirators%3A+extended+service+life+versus+increased+user+burden.&rft.au=Roberge%2C+Raymond+J&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2008-03-01&rft.volume=14&rft.issue=2&rft.spage=E19&rft.isbn=&rft.btitle=&rft.title=Journal+of+public+health+management+and+practice+%3A+JPHMP&rft.issn=1550-5022&rft_id=info:doi/10.1097%2F01.PHH.0000311904.41691.fd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.PHH.0000311904.41691.fd ER - TY - JOUR T1 - Ethnic, racial, and gender variations in health among farm operators in the United States. AN - 70300364; 18280919 AB - The purpose of this study was to collect baseline prevalence data on the health problems faced by minority, white, and female farm operators. An occupational health survey of farm operators was conducted by the U.S. Department of Agriculture, National Agricultural Statistics Service between February and August 2000. A stratified random sample of farm operators from 50 U.S. states based on the 1997 Census of Agriculture was selected for telephone interview. Interviews were primarily conducted using a computer assisted telephone instrument system. Population prevalences were calculated for 7137 farm operators. Prevalences were greatest for musculoskeletal discomfort, followed by respiratory problems, hearing loss, and hypertension. Generally, Latino and Asian American operators had lower prevalences for health problems than white non-Latino and white operators, respectively. African-American operators had greater prevalences for hypertension, and osteoarthritis, but lower prevalences for hearing loss, skin problems, heart problems, and cancer than white operators. American Indian or Alaska Native operators had higher prevalences for musculoskeletal problems, skin problems, and hypertension. Prevalences for the different ethnicity and race groups are not the same. Studies that combine racial and ethnic groups, or study only white and non-Latino farm operators may overestimate or underestimate the prevalence of health conditions in the entire farm operator population. JF - Annals of epidemiology AU - Alterman, Toni AU - Steege, Andrea L AU - Li, Jia AU - Petersen, Martin R AU - Muntaner, Carles AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45213, USA. talterman@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 179 EP - 186 VL - 18 IS - 3 SN - 1047-2797, 1047-2797 KW - Index Medicus KW - Occupational Health KW - Sex Factors KW - Humans KW - Aged KW - Population Surveillance KW - Demography KW - Aged, 80 and over KW - Logistic Models KW - Adult KW - Interviews as Topic KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Agriculture KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Ethnic%2C+racial%2C+and+gender+variations+in+health+among+farm+operators+in+the+United+States.&rft.au=Alterman%2C+Toni%3BSteege%2C+Andrea+L%3BLi%2C+Jia%3BPetersen%2C+Martin+R%3BMuntaner%2C+Carles&rft.aulast=Alterman&rft.aufirst=Toni&rft.date=2008-03-01&rft.volume=18&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-03 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annepidem.2007.11.014 ER - TY - JOUR T1 - The national study to prevent blood exposure in paramedics: exposure reporting. AN - 70295988; 18213637 AB - This survey was conducted to provide national incidence rates and risk factors for exposure to blood among paramedics. The present analysis assesses reporting of exposures to employers. A questionnaire was mailed in 2002-2003 to a national sample of paramedics selected using a two-stage design. Information on exposure reporting was obtained on the two most recent exposures for each of five routes of exposure. Forty-nine percent of all exposures to blood and 72% of needlesticks were reported to employers. The main reason for under-reporting was not considering the exposure a "significant risk." Females reported significantly more total exposures than males. Reporting of needlesticks was significantly less common among respondents who believed most needlesticks were due to circumstances under the worker's control. Reporting was non-significantly more common among workers who believed reporting exposures helps management prevent future exposures. Reporting may have been positively associated with workplace safety culture. This survey indicates there is need to improve the reporting of blood exposures by paramedics to their employers, and more work is needed to understand the reasons for under-reporting. Gender, safety culture, perception of risk, and other personal attitudes may all affect reporting behavior. JF - American journal of industrial medicine AU - Boal, Winifred L AU - Leiss, Jack K AU - Sousa, Sara AU - Lyden, Jennifer T AU - Li, Jia AU - Jagger, Janine AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. wboal@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 213 EP - 222 VL - 51 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Body Fluids KW - Humans KW - Safety Management KW - Risk Factors KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Bites and Stings -- epidemiology KW - Occupational Exposure -- statistics & numerical data KW - Blood KW - Occupational Exposure -- prevention & control KW - Disclosure -- statistics & numerical data KW - Attitude of Health Personnel KW - Needlestick Injuries -- prevention & control KW - Allied Health Personnel -- statistics & numerical data KW - Needlestick Injuries -- epidemiology KW - Allied Health Personnel -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70295988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=The+national+study+to+prevent+blood+exposure+in+paramedics%3A+exposure+reporting.&rft.au=Boal%2C+Winifred+L%3BLeiss%2C+Jack+K%3BSousa%2C+Sara%3BLyden%2C+Jennifer+T%3BLi%2C+Jia%3BJagger%2C+Janine&rft.aulast=Boal&rft.aufirst=Winifred&rft.date=2008-03-01&rft.volume=51&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20558 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20558 ER - TY - JOUR T1 - Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds. AN - 70280385; 18065775 AB - 13C NMR data have been correlated to Toxic Equivalency Factors (TEFs) of the 29 PCDDs, PCDFs, or PCBs for which non-zero TEFs have been defined. Such correlations are called quantitative spectrometric data-activity relationship (QSDAR) models. An improved QSDAR model predicted TEFs of 0.037 and 0.004, respectively, for 1,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7-pentachlorodibenzo-p-dioxin (PeCDD), both among the 390 congeners for which zero value TEFs are assumed. A QSDAR model of Relative Potency (REP) values estimated the corresponding values as 0.115 and 0.020. Results from both models indicated that these two congeners may exhibit significant dioxin-like toxicity. If other such congeners have non-zero toxicity, TEF-based risk assessments of some dioxin-, furan-, or PCB-contaminated sites or foods may underestimate toxicity. Both models were extensively cross-validated and the TEF model was externally validated. We confirmed the predictions by an independent in vitro method, a luciferase gene expression assay based on mouse liver cells that found REPs of 0.027 and 0.013, respectively, for 1,3,7,8-TCDD and 1,2,3,4,7-PeCDD. The QSDAR-estimated and gene-expression assayed values agreed. The models were used to predict activity for an applicability domain including 108 non-2,3,7,8 dioxin, furan, or PCB congeners and 2,3,7,8-tetrachlorophenothiazine, a dioxin analog proposed as a drug candidate. This study showed that QSDAR prediction followed by a relatively inexpensive in vitro assay could be used to nominate a few candidates among hundreds for further investigation. It suggested that in silico and in vitro nomination protocols may facilitate practical risk assessment when chemical family members exhibit different degrees of toxicity operating via a common mechanism. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wilkes, Jon G AU - Hass, Bruce S AU - Buzatu, Dan A AU - Pence, Lisa M AU - Archer, Jeffrey C AU - Beger, Richard D AU - Schnackenberg, Laura K AU - Halbert, Mary Kim AU - Jennings, Lisa AU - Kodell, Ralph L AD - Division of Systems Toxicology, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA. jone.wilkes@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 187 EP - 195 VL - 102 IS - 1 SN - 1096-6080, 1096-6080 KW - Dioxins KW - 0 KW - Environmental Pollutants KW - Furans KW - Receptors, Aryl Hydrocarbon KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Molecular Structure KW - Animals KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - Liver -- metabolism KW - Mice KW - Risk Assessment KW - Quantitative Structure-Activity Relationship KW - Transfection KW - Liver -- drug effects KW - Genes, Reporter KW - Receptors, Aryl Hydrocarbon -- agonists KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Gene Expression Regulation -- drug effects KW - Cell Line KW - Furans -- chemistry KW - Environmental Pollutants -- toxicity KW - Dioxins -- chemistry KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- chemistry KW - Furans -- toxicity KW - Biological Assay KW - Toxicity Tests -- methods KW - Environmental Pollutants -- chemistry KW - Dioxins -- toxicity KW - Models, Biological KW - Magnetic Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70280385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Modeling+and+assaying+dioxin-like+biological+effects+for+both+dioxin-like+and+certain+non-dioxin-like+compounds.&rft.au=Wilkes%2C+Jon+G%3BHass%2C+Bruce+S%3BBuzatu%2C+Dan+A%3BPence%2C+Lisa+M%3BArcher%2C+Jeffrey+C%3BBeger%2C+Richard+D%3BSchnackenberg%2C+Laura+K%3BHalbert%2C+Mary+Kim%3BJennings%2C+Lisa%3BKodell%2C+Ralph+L&rft.aulast=Wilkes&rft.aufirst=Jon&rft.date=2008-03-01&rft.volume=102&rft.issue=1&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of nonstandard noise dosimeter microphone positions. AN - 70230568; 18213533 AB - This study was conducted as part of a project involving the evaluation of a new type of noise exposure monitoring paradigm. Laboratory tests were conducted to assess how "nonstandard" dosimeter microphones and microphone positions measured noise levels under different acoustical conditions (i.e., diffuse field and direct field). The data presented in this article reflect measurement differences due to microphone position and mounting/supporting structure only and are not an evaluation of any particular complete dosimeter system. To varying degrees, the results obtained with the dosimeter microphones used in this study differed from the reference results obtained in the unperturbed (subject absent) sound field with a precision (suitable for use in an ANSI Type 1 sound level meter) (1)/(2)-inch (12.7 mm) measurement microphone. Effects of dosimeter microphone placement in a diffuse field were found to be minor for most of the test microphones/locations, while direct field microphone placement effects were found to be quite large depending on the microphone position and supporting structure, sound source location, and noise spectrum. JF - Journal of occupational and environmental hygiene AU - Byrne, David C AU - Reeves, Efrem R AD - Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. dbyrne@cdc.gov. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 197 EP - 209 VL - 5 IS - 3 KW - Index Medicus KW - Humans KW - Adult KW - Sound KW - Middle Aged KW - Pennsylvania KW - Male KW - Female KW - Noise, Occupational -- statistics & numerical data KW - Acoustics -- instrumentation KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70230568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Analysis+of+nonstandard+noise+dosimeter+microphone+positions.&rft.au=Byrne%2C+David+C%3BReeves%2C+Efrem+R&rft.aulast=Byrne&rft.aufirst=David&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620701879438 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-08 N1 - Date created - 2008-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620701879438 ER - TY - JOUR T1 - The use of immunochemical and biosensor methods for occupational and environmental monitoring. Part II: Immunoassay data analysis and immunobiosensors. AN - 70108159; 18074294 JF - Journal of occupational and environmental hygiene AU - Ashley, Kevin AU - Biagini, Raymond E AU - Smith, Jerry P AU - Sammons, Deborah L AU - MacKenzie, Barbara A AU - Striley, Cynthia A F AU - Robertson, Shirley K AU - Snawder, John E AD - Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - D37 EP - D42 VL - 5 IS - 3 KW - Antibodies KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Potentiometry -- methods KW - Potentiometry -- instrumentation KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Logistic Models KW - Enzyme-Linked Immunosorbent Assay -- instrumentation KW - Calibration KW - Occupational Exposure -- analysis KW - Immunoassay -- methods KW - Data Interpretation, Statistical KW - Biosensing Techniques -- methods KW - Biosensing Techniques -- instrumentation KW - Environmental Monitoring -- methods KW - Immunoassay -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70108159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+use+of+immunochemical+and+biosensor+methods+for+occupational+and+environmental+monitoring.+Part+II%3A+Immunoassay+data+analysis+and+immunobiosensors.&rft.au=Ashley%2C+Kevin%3BBiagini%2C+Raymond+E%3BSmith%2C+Jerry+P%3BSammons%2C+Deborah+L%3BMacKenzie%2C+Barbara+A%3BStriley%2C+Cynthia+A+F%3BRobertson%2C+Shirley+K%3BSnawder%2C+John+E&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=D37&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-08 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-environment interactions in the development of complex disease phenotypes. AN - 69145908; 18441400 AB - The lack of knowledge about the earliest events in disease development is due to the multi-factorial nature of disease risk. This information gap is the consequence of the lack of appreciation for the fact that most diseases arise from the complex interactions between genes and the environment as a function of the age or stage of development of the individual. Whether an environmental exposure causes illness or not is dependent on the efficiency of the so-called "environmental response machinery" (i.e., the complex of metabolic pathways that can modulate response to environmental perturbations) that one has inherited. Thus, elucidating the causes of most chronic diseases will require an understanding of both the genetic and environmental contribution to their etiology. Unfortunately, the exploration of the relationship between genes and the environment has been hampered in the past by the limited knowledge of the human genome, and by the inclination of scientists to study disease development using experimental models that consider exposure to a single environmental agent. Rarely in the past were interactions between multiple genes or between genes and environmental agents considered in studies of human disease etiology. The most critical issue is how to relate exposure-disease association studies to pathways and mechanisms. To understand how genes and environmental factors interact to perturb biological pathways to cause injury or disease, scientists will need tools with the capacity to monitor the global expression of thousands of genes, proteins and metabolites simultaneously. The generation of such data in multiple species can be used to identify conserved and functionally significant genes and pathways involved in gene-environment interactions. Ultimately, it is this knowledge that will be used to guide agencies such as the U.S. Department of Health and Human Services in decisions regarding biomedical research funding and policy. JF - International journal of environmental research and public health AU - Ramos, Rosemarie G AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD- NH04, Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 4 EP - 11 VL - 5 IS - 1 KW - Index Medicus KW - Phenotype KW - Occupational Diseases -- genetics KW - Environmental Health -- trends KW - Disease Susceptibility -- epidemiology KW - Humans KW - Occupational Diseases -- epidemiology KW - Chronic Disease KW - Research -- trends KW - Environmental Exposure KW - Genetic Predisposition to Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Gene-environment+interactions+in+the+development+of+complex+disease+phenotypes.&rft.au=Ramos%2C+Rosemarie+G%3BOlden%2C+Kenneth&rft.aulast=Ramos&rft.aufirst=Rosemarie&rft.date=2008-03-01&rft.volume=5&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Dec 10;83(6):743-9 [10597189] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Am J Ind Med. 2001 Mar;39(3):286-91 [11241561] Nat Rev Genet. 2000 Nov;1(2):149-53 [11253655] Toxicol Appl Pharmacol. 2001 Apr 1;172(1):75-82 [11264025] Biochim Biophys Acta. 2001;1471(2):C1-10 [11342183] Am J Public Health. 2001 Dec;91(12):1964-7 [11726375] Eur Respir J Suppl. 2001 Sep;32:127s-133s [11816820] J Immunol. 1999 Aug 1;163(3):1647-53 [10415070] Am J Hum Genet. 1962 Dec;14:353-62 [13937884] J Occup Environ Hyg. 2004 Oct;1(10):648-59 [15631056] Transpl Immunol. 2005 Aug;14(3-4):175-82 [15982560] J Occup Environ Hyg. 2005 Jun;2(6):D48-50 [16020086] Trends Immunol. 2005 Oct;26(10):543-9 [16099719] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Diabetes. 2005 Dec;54 Suppl 2:S125-36 [16306330] Science. 2005 Nov 25;310(5752):1325-6 [16311335] J Occup Environ Med. 2006 Feb;48(2):204-11 [16474270] Am J Prev Med. 2006 Aug;31(2):109-17 [16829327] Ann N Y Acad Sci. 2006 Sep;1076:703-6 [17119247] Lancet. 2007 Mar 10;369(9564):844-9 [17350453] Eur Respir J. 2007 Apr;29(4):793-803 [17400878] Int J Cancer. 2007 Jun 15;120(12):2739-43 [17290392] Am J Health Promot. 2007 Mar-Apr;21(4 Suppl):326-34 [17465178] Ann Allergy Asthma Immunol. 2007 May;98(5):455-63 [17521030] Circulation. 2007 Jun 5;115(22):2878-901 [17515457] Diabetes Obes Metab. 2007 Jul;9(4):548-57 [17587397] Proc Am Thorac Soc. 2007 Jul;4(3):221-5 [17607003] Ind Health. 2007 Jun;45(3):379-87 [17634686] Stroke. 2007 Aug;38(8):2221-7 [17600228] J Allergy Clin Immunol. 2007 Aug;120(2):322-8 [17543375] Environ Health Perspect. 2007 Sep;115(9):1264-70 [17805414] Inhal Toxicol. 2007;19 Suppl 1:161-75 [17886064] Int J Mol Med. 2007 Nov;20(5):703-7 [17912464] Occup Environ Med. 2007 Nov;64(11):717-8 [17951339] Diabet Med. 2007 Nov;24(11):1187-91 [17894829] Am J Med Genet. 2002 May 30;115(1):8-17 [12116172] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):219-24 [12162437] Am J Prev Med. 2003 Feb;24(2):136-42 [12568819] EHP Toxicogenomics. 2003 Jan;111(1T):15-28 [12735106] JAMA. 2003 Aug 20;290(7):891-7 [12928465] Scand J Work Environ Health. 2004 Feb;30(1):71-9 [15018031] Int J Occup Environ Health. 2004 Jan-Mar;10(1):22-5 [15070022] Int J Occup Med Environ Health. 2004;17(1):103-10 [15212212] Am Rev Respir Dis. 1989 Jun;139(6):1479-86 [2729754] Environ Health Perspect. 1993 Apr 22;101(1):6-7 [8513765] Science. 1993 Oct 8;262(5131):242-4 [8105536] Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):471-7 [8000297] J Mol Med (Berl). 1995 Aug;73(8):381-93 [8528740] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1076-81 [8887610] Environ Health Perspect. 1996 Oct;104 Suppl 5:937-43 [8933038] Science. 1997 Oct 24;278(5338):569-70 [9381162] Nat Genet. 1998 Feb;18(2):91-3 [9462728] Environ Health Perspect. 1998 Jul;106(7):365-8 [9637792] Am J Ind Med. 1998 Oct;34(4):318-24 [9750937] Eur Respir J. 1998 Dec;12(6):1463-75 [9877510] JAMA. 1999 Jan 27;281(4):341-6 [9929087] Toxicol Sci. 1999 Feb;47(2):135-43 [10220849] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] Science. 2000 Jul 28;289(5479):536-7 [10939962] Environ Health Perspect. 2000 Aug;108 Suppl 4:675-84 [10931786] Mutat Res. 2001 Jan 25;473(1):3-10 [11166022] Nature. 2001 Feb 15;409(6822):860-921 [11237011] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - UVA photoirradiation of oxygenated benz[a]anthracene and 3-methylcholanthene--generation of singlet oxygen and induction of lipid peroxidation. AN - 69145780; 18441402 AB - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants and potentially pose a health risk to humans. Although the biological and toxicological activities, including metabolism, mutagenicity, and carcinogenicity, of PAHs have been thoroughly studied, their phototoxicity and photo-induced biological activity have not been well examined. We have long been interested in phototoxicity of PAHs and their derivatives induced by irradiation with UV light. In this paper we report the photoirradiation of a series of oxygenated benz[a]anthracene (BA) and 3-methylcholanthene (3-MC) by UVA light in the presence of a lipid, methyl linoleate. The studied PAHs include 2-hydroxy-BA (2-OH-BA), 3-hydroxy-BA (3-OH-BA), 5-hydroxymethyl-BA (5- CH2OH-BA), 7-hydroxymethyl-BA (7-CH2OH-BA), 12-hydroxymethyl-BA (12-CH2OH-BA), 7-hydroxymethyl-12- methyl-BA (7-CH2OH-12-MBA), 5-formyl-BA (5-CHO-BA), BA 5,6-cis-dihydrodiol (BA 5,6-cis-diol), 1-hydroxy-3- methylcholanthene (1-OH-3-MC), 1-keto-3-methylcholanthene (1-keto-3-MC), and 3-MC 1,2-diol. The results indicate that upon photoirradiation by UVA at 7 and 21 J/cm2, respectively all these compounds induced lipid peroxidation and exhibited a relationship between the dose of the light and the level of lipid peroxidation induced. To determine whether or not photoirradiation of these compounds by UVA light produces ROS, an ESR spin-trap technique was employed to provide direct evidence. Photoirradiation of 3-keto-3-MC by UVA (at 389 nm) in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. These overall results suggest that UVA photoirradiation of oxygenated BA and 3-methylcholanthrene generates singlet oxygen, one of the reactive oxygen species (ROS), which induce lipid peroxidation. JF - International journal of environmental research and public health AU - Yin, Jun-Jie AU - Xia, Qingsu AU - Cherng, Shu-Hui AU - Tang, I-Wah AU - Fu, Peter P AU - Lin, Ge AU - Yu, Hongtao AU - Sáenz, Diógenes Herreño AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 26 EP - 31 VL - 5 IS - 1 KW - Benz(a)Anthracenes KW - 0 KW - Linoleic Acids KW - Singlet Oxygen KW - 17778-80-2 KW - methyl linoleate KW - 24N6726DE5 KW - Methylcholanthrene KW - 56-49-5 KW - benz(a)anthracene KW - C5PLF6152K KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Linoleic Acids -- radiation effects KW - Electron Spin Resonance Spectroscopy KW - Singlet Oxygen -- chemistry KW - Linoleic Acids -- chemistry KW - Lipid Peroxidation -- radiation effects KW - Ultraviolet Rays KW - Methylcholanthrene -- analogs & derivatives KW - Benz(a)Anthracenes -- radiation effects KW - Oxygen -- chemistry KW - Methylcholanthrene -- chemistry KW - Benz(a)Anthracenes -- chemistry KW - Methylcholanthrene -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=UVA+photoirradiation+of+oxygenated+benz%5Ba%5Danthracene+and+3-methylcholanthene--generation+of+singlet+oxygen+and+induction+of+lipid+peroxidation.&rft.au=Yin%2C+Jun-Jie%3BXia%2C+Qingsu%3BCherng%2C+Shu-Hui%3BTang%2C+I-Wah%3BFu%2C+Peter+P%3BLin%2C+Ge%3BYu%2C+Hongtao%3BS%C3%A1enz%2C+Di%C3%B3genes+Herre%C3%B1o&rft.aulast=Yin&rft.aufirst=Jun-Jie&rft.date=2008-03-01&rft.volume=5&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477] Photochem Photobiol. 2007 Mar-Apr;83(2):409-24 [17576350] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):149-83 [12515673] Biochim Biophys Acta. 2004 Jan 30;1608(1):63-73 [14741586] Mutat Res. 2004 Aug 8;562(1-2):143-50 [15279837] Nature. 1976 Sep 30;263(5576):442-3 [972689] Lancet. 1980 Apr 5;1(8171):732-5 [6103156] Carcinogenesis. 1982;3(2):215-7 [7067048] Anal Biochem. 1987 Jun;163(2):343-9 [3116881] Mutat Res. 1989 Oct;216(5):231-42 [2552308] Chem Res Toxicol. 1992 Mar-Apr;5(2):220-6 [1643251] Mutat Res. 1992 Nov;298(1):31-41 [1279414] J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511] Environ Health Perspect. 1996 Nov;104(11):1166-70 [8959405] Chem Res Toxicol. 1999 Jan;12(1):1-18 [9894013] Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116] Toxicol Lett. 2006 May 5;163(1):30-43 [16384671] Int J Environ Res Public Health. 2005 Apr;2(1):114-22 [16705809] Toxicol Ind Health. 2006 May;22(4):147-56 [16786836] Int J Environ Res Public Health. 2006 Jun;3(2):191-5 [16823092] Int J Environ Res Public Health. 2006 Dec;3(4):348-54 [17159277] Toxicol Lett. 2007 Jan 30;168(2):165-75 [17197137] Int J Environ Res Public Health. 2007 Jun;4(2):153-7 [17617679] Methods Enzymol. 2000;319:290-6 [10907520] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Keeping a Safe Distance: Individualism and the Less Punitive Public AN - 61677567; 200819395 AB - This article will address individual differences in punitiveness or 'get tough' attitudes towards lawbreakers, but will do so by looking in depth at the nature of worldviews that have been identified as decidedly forgiving. The aim is to generate new hypotheses through a grounded narrative analysis regarding a dimension of public sensibilities towards crime-leniency-about which we know very little. I conclude that social identity is an important aspect of merciful worldviews, and that a precondition of a forgiving orientation may be a focus on individual agency. This analysis is supported by quantitative tests of new hypotheses to emerge. This article contributes to the more complex picture of differentiated public opinion to crime and criminal justice that has emerged recently in the literature. Adapted from the source document. JF - British Journal of Criminology AU - King, Anna AD - Rutgers University, Center for Mental Health Services and Criminal Justice Research, 176 Ryders Lane, New Brunswick, NJ 08901, USA aking@ifh.rutgers.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 190 EP - 208 PB - Oxford University Press, UK VL - 48 IS - 2 SN - 0007-0955, 0007-0955 KW - Attitudes KW - Individualism KW - Punishment KW - Criminal Justice Policy KW - Public Opinion KW - article KW - 2147: social problems and social welfare; sociology of crime UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61677567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Criminology&rft.atitle=Keeping+a+Safe+Distance%3A+Individualism+and+the+Less+Punitive+Public&rft.au=King%2C+Anna&rft.aulast=King&rft.aufirst=Anna&rft.date=2008-03-01&rft.volume=48&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Criminology&rft.issn=00070955&rft_id=info:doi/10.1093%2Fbjc%2Fazm069 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-07-03 N1 - Number of references - 53 N1 - Last updated - 2016-09-28 N1 - CODEN - BJCDAR N1 - SubjectsTermNotLitGenreText - Punishment; Individualism; Attitudes; Criminal Justice Policy; Public Opinion DO - http://dx.doi.org/10.1093/bjc/azm069 ER - TY - JOUR T1 - Sex and Race Differences in Mental Health Symptoms in Juvenile Justice: The MAYSI-2 National Meta-Analysis AN - 57248970; 200815537 AB - Objective: Studies have suggested a high prevalence of mental health symptoms among youths in the juvenile justice system, with the highest prevalence among girls and whites compared to boys and other races. This multisite, archival study examined whether sex and race differences, when they exist, were consistent across U.S. juvenile justice programs. Method: Data included scores on the Massachusetts Youth Screening Instrument-Version 2 (MAYSI-2) for 70,423 youths from 283 juvenile justice probation, detention, or corrections programs. A meta-analytic technique investigated the consistency of effect sizes for sex and race/ethnic differences across sites in self-reported mental health problems. Results: Across sites, girls on average were 1.8 (95% confidence interval 0.98-1.10) to 2.4 (95% confidence interval 2.38-2.48) times as likely as boys to have clinical elevations on all applicable MAYSI-2 scales except the Alcohol/Drug Use scale. On the Alcohol/Drug Use scale, a sex effect existed but only among younger youths. Whites were more likely to have clinical elevations than blacks or Hispanics, but surprisingly disparities varied across mental health categories and varied considerably across sites. Conclusion: At the aggregate level, 72% of girls and 63% of boys had a clinical elevation on at least one MAYSI-2 scale. Our meta-analytic technique indicated that the sex differences across sites were even larger than these numbers imply. Conversely and counter to existing evidence, race-related differences were generally small or nonexistent. Whites were more likely to have alcohol and drug problems and suicide ideation, but not more likely to have symptoms of depression, anxiety, or thought disturbance than blacks or Hispanics. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vincent, Gina M AU - Grisso, Thomas AU - Terry, Anna AU - Banks, Steven AD - Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 gina.vincent@umassmed.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 282 EP - 290 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 3 SN - 0890-8567, 0890-8567 KW - Massachusetts Youth Screening Instrument-Version 2, juvenile justice, mental disorder, race, sex KW - Mental illness KW - Racial differences KW - Delinquents KW - Gender differences KW - Juvenile justice KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57248970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Sex+and+Race+Differences+in+Mental+Health+Symptoms+in+Juvenile+Justice%3A+The+MAYSI-2+National+Meta-Analysis&rft.au=Vincent%2C+Gina+M%3BGrisso%2C+Thomas%3BTerry%2C+Anna%3BBanks%2C+Steven&rft.aulast=Vincent&rft.aufirst=Gina&rft.date=2008-03-01&rft.volume=47&rft.issue=3&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b013e318160d516 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Racial differences; Adolescents; Mental illness; Juvenile justice; Gender differences; Delinquents DO - http://dx.doi.org/10.1097/chi.0b013e318160d516 ER - TY - RPRT T1 - FOREWORD AN - 236520695 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236520695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY: STUDY OF GENISTEIN (CAS NO. 446-72-0) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 236459805; 18685713 AB - Genistein is an isoflavone that occurs in soy products including soy-based infant formulas. Genistein is one of a class of chemicals known as "environmental estrogens," which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure to such chemicals over the course of multiple generations could have any cumulative effect on animals' reproductive systems. This report describes the results of a set of studies in which several generations of rats were exposed to genistein through their feed and/or through exposure from their mothers through gestation and weaning. The study extended over five generations of rats following a parental group of rats that were exposed to genistein in their feed starting at the age of 6 weeks. The first and second generations of offspring were exposed to genistein during conception through their mothers, during weaning through their mothers' milk, and during their lifetimes through feed containing genistein. The third generation was exposed just during gestation and weaning, and the fourth and fifth generations were not exposed directly, to see if any carryover effects resided from exposure of earlier generations. The dosed feed contained 5, 100, or 500 parts per million (ppm) of genistein. The primary measures examined during each generation were body weights, development of reproductive organs, and number of offspring per litter after each cycle of mating. Female rats given 500 ppm in their feed had lower body weights, accelerated sexual maturation, and altered estrous cyclicity compared to unexposed animals. Male rats given 500 ppm in the feed had lower body weights in the first generation but not in the second generation, with similar chemical exposure. For animals continuously exposed to genistein, there was some reduction in litter size in the first two generations. Male rats exposed to 100 or 500 ppm had increased rates of mammary gland hyperplasia and calcification of renal tubules. In the later generations, the only observed effects on offspring of exposed animals were smaller body weight gains in pups before weaning. We conclude that exposure to 500 ppm of genistein caused lower body weights and some alterations in the reproductive system of female rats. Exposure to genistein caused lower body weights in one generation of male rats and increases in mammary gland hyperplasia and renal tubule calcification. Except for lower body weights in pups, there was no evidence for a carryover of genistein effects into unexposed generations. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1 EP - 266 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Phytoestrogens KW - Genistein KW - Toxicology KW - Rodents KW - Chemicals KW - Animal reproduction KW - Animals KW - Pituitary Neoplasms -- chemically induced KW - Adenocarcinoma -- chemically induced KW - Mammary Neoplasms, Animal -- pathology KW - Recovery of Function KW - Mammary Neoplasms, Animal -- chemically induced KW - Neoplasms, Experimental -- pathology KW - Pregnancy KW - Adenocarcinoma -- pathology KW - Rats KW - Rats, Sprague-Dawley KW - Pituitary Neoplasms -- pathology KW - Adenoma -- chemically induced KW - Withholding Treatment KW - Adenoma -- pathology KW - Female KW - Male KW - Phytoestrogens -- toxicity KW - Reproduction -- drug effects KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests, Chronic KW - Carcinogens -- toxicity KW - Genistein -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236459805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=MULTIGENERATIONAL+REPRODUCTIVE+TOXICOLOGY%3A+STUDY+OF+GENISTEIN+%28CAS+NO.+446-72-0%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236441006 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Highly Variable Drugs: Observations from Bioequivalence Data Submitted to the FDA for New Generic Drug Applications AN - 21262969; 11178374 JF - AAPS Journal AU - Davit, Barbara M AU - Conner, Dale P AU - Fabian-Fritsch, Beth AU - Haidar, Sam H AU - Jiang, Xiaojian AU - Patel, Devvrat T AU - Seo, Paul R H AU - Suh, Keri AU - Thompson, Christina L AU - Yu, Lawrence X AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, 7520 Standish Place, Rockville, Maryland 20855, USA, barbara.davit@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 148 EP - 156 PB - American Association of Pharmaceutical Scientists VL - 10 IS - 1 SN - 1550-7416, 1550-7416 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21262969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Highly+Variable+Drugs%3A+Observations+from+Bioequivalence+Data+Submitted+to+the+FDA+for+New+Generic+Drug+Applications&rft.au=Davit%2C+Barbara+M%3BConner%2C+Dale+P%3BFabian-Fritsch%2C+Beth%3BHaidar%2C+Sam+H%3BJiang%2C+Xiaojian%3BPatel%2C+Devvrat+T%3BSeo%2C+Paul+R+H%3BSuh%2C+Keri%3BThompson%2C+Christina+L%3BYu%2C+Lawrence+X&rft.aulast=Davit&rft.aufirst=Barbara&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9015-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Drugs DO - http://dx.doi.org/10.1208/s12248-008-9015-x ER - TY - JOUR T1 - Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes AN - 21201968; 11621735 AB - Drug-metabolizing enzymes are an important battery of proteins that are involved in drug metabolism, xenobiotic detoxification, and drug-induced toxicity. Systematic, efficient, and simultaneous evaluation of drug-metabolizing gene expression in response to chemicals has a wide variety of implications in drug development, disease prevention, and personalized medicine and nutrition. In the current study, the authors have systematically and simultaneously evaluated the hepatic expression profile of drug-metabolizing enzymes in cultured human hepatocytes exposed to the xenobiotics rifampicin, omeprazole, and 3-methylcholanthrene (3-MC) using the Drug Metabolism RT super(2)Profiler+ PCR Arrays. This new high-throughput tool allowed the authors to evaluate the expression of genes coding for 84 drug-metabolizing enzymes (including phase 1 and phase 2 drug-metabolizing enzymes and transporters) simultaneously, in a 96-well format using a small amount of experimental materials. To validate the quality of the Drug Metabolism RT super(2)Profiler+ PCR Arrays, the PCR Array was compared with the well-documented platform TaqMan assay, and a high concordance was shown between these 2 methods, indicating the high reliability of the Drug Metabolism RT super(2)Profiler+ PCR Arrays. In addition, increasing or decreasing the expression of drug-metabolizing enzymes by these 3 compounds was observed, and underlying mechanisms are discussed. (Journal of Biomolecular Screening 2008; 194-201) JF - Journal of Biomolecular Screening AU - Ning, Baitang AU - Dial, Stacey AU - Sun, Yanyang AU - Wang, Jie AU - Yang, Jingping AU - Guo, Lei AD - Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 194 EP - 201 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 3 SN - 1087-0571, 1087-0571 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - real time-PCR KW - gene expression KW - drug-metabolizing enzyme KW - drug-metabolizing gene KW - Detoxification KW - Hepatocytes KW - Drug metabolism KW - 3-Methylcholanthrene KW - Omeprazole KW - Enzymes KW - Drug development KW - Toxicity KW - Nutrition KW - Gene expression KW - Rifampin KW - Liver KW - Polymerase chain reaction KW - G 07730:Development & Cell Cycle KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Systematic+and+Simultaneous+Gene+Profiling+of+84+Drug-Metabolizing+Genes+in+Primary+Human+Hepatocytes&rft.au=Ning%2C+Baitang%3BDial%2C+Stacey%3BSun%2C+Yanyang%3BWang%2C+Jie%3BYang%2C+Jingping%3BGuo%2C+Lei&rft.aulast=Ning&rft.aufirst=Baitang&rft.date=2008-03-01&rft.volume=13&rft.issue=3&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057108315513 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Detoxification; Hepatocytes; Drug metabolism; 3-Methylcholanthrene; Enzymes; Omeprazole; Drug development; Toxicity; Nutrition; Gene expression; Rifampin; Liver; Polymerase chain reaction DO - http://dx.doi.org/10.1177/1087057108315513 ER - TY - JOUR T1 - Comparative Evaluation of Flow for Pharmaceutical Powders and Granules AN - 21123105; 11176751 AB - The objective of the present work was to carry out a systematic evaluation of flow of pharmaceutical powders and granules using compendial and non-compendial methods. Angle of repose, bulk density, tapped density, Carr's compressibility index, and Hausner ratios were evaluated. Additionally, flow was characterized using a powder rheometer in which a sensitive force transducer monitors the forces generated as a result of the sample displacement. The critical attributes such as cohesivity index, caking strength, and flow stability were determined for samples. The samples consisted of different grades of magnesium stearate powder including bovine, vegetable, and food grade, physical mixture powder blend consisting of a model formulation, granules prepared by various methods including slugging, high shear granulator, and fluid bed dryer. Lubricant efficiency was also determined for granules lubricated with various concentrations of magnesium stearate. It was observed that the compendial methods were often non-discriminating for minor variations in powder flow. The additional characterization such as cohesivity, and caking strength were helpful in understanding the flow characteristics of pharmaceutical systems. The flow stability test determined that the powders were not affected by the test conditions on the rheometer. The non-compendial tests were discriminating to even minor variations in powder flow. JF - AAPS PharmSciTech AU - Shah, Rakhi B AU - Tawakkul, Mobin A AU - Khan, Mansoor A AD - Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA, Mansoor.khan@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 250 EP - 258 PB - Springer New York LLC VL - 9 IS - 1 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Granules KW - Powder KW - Vegetables KW - Lubricants KW - Food KW - Pharmaceuticals KW - Compressibility KW - Magnesium KW - Models KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21123105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Comparative+Evaluation+of+Flow+for+Pharmaceutical+Powders+and+Granules&rft.au=Shah%2C+Rakhi+B%3BTawakkul%2C+Mobin+A%3BKhan%2C+Mansoor+A&rft.aulast=Shah&rft.aufirst=Rakhi&rft.date=2008-03-01&rft.volume=9&rft.issue=1&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fs12249-008-9046-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Granules; Powder; Vegetables; Food; Lubricants; Compressibility; Pharmaceuticals; Magnesium; Models DO - http://dx.doi.org/10.1208/s12249-008-9046-8 ER - TY - JOUR T1 - Assessment of Clostridium difficile-Associated Disease Surveillance Definitions, North Carolina, 2005 AN - 21042633; 8585039 AB - Objective. To determine the timing of community-onset Clostridium difficile-associated disease (CDAD) relative to the patient's last healthcare facility discharge, the association of postdischarge cases with healthcare facility-onset cases, and the influence of postdischarge cases on overall rates and interhospital comparison of rates of CDAD. Design. Retrospective cohort study for the period January 1, 2005, through December 31, 2005. Setting. Catchment areas of 6 acute care hospitals in North Carolina. Methods. We reviewed medical and laboratory records to determine the date of symptom onset, the dates of hospitalization, and stool C. difficile toxin assay results for patients with CDAD who had diarrhea and positive toxin-assay results. Cases were classified as healthcare facility- onset if they were diagnosed more than 48 hours after admission. Cases were defined as community-onset if they were diagnosed in the community or within 48 hours after admission, and were also classified on the basis of the time since the last discharge: if within 4 weeks, community-onset, healthcare facility-associated (CO-HCFA); if 4-12 weeks, indeterminate exposure; and if more than 12 weeks, community-associated. Pearson's correlation coefficient was used to assess the association between monthly rates of healthcare facility-onset, healthcare facility-associated (HO-HCFA) cases and CO-HCFA cases. We performed interhospital rate comparisons using HO-HCFA cases only and using both HO-HCFA and CO-HCFA cases. Results. Of 1046 CDAD cases, 442 (42%) were HO-HCFA cases and 604 (58%) were community-onset cases. Of the 604 community-onset cases, 94 (15%) were CO-HCFA, 40 (7%) were of indeterminate exposure, and 208 (34%) community-associated. A modest correlation was found between monthly rates of HO-HCFA cases and CO-HCFA cases across the 6 hospitals . Interhospital rankings changed for 6 of 11 months if CO-HCFA cases were included. Conclusions. A substantial proportion of community-onset cases of CDAD occur less than 4 weeks after discharge from a healthcare facility, and inclusion of CO-HCFA cases influences interhospital comparisons. Our findings support the use of a proposed definition of healthcare facility-associated CDAD that includes cases that occur within 4 weeks after discharge. JF - Infection Control and Hospital Epidemiology AU - Kutty, Preeta K AU - Benoit, Stephen R AU - Woods, Christopher W AU - Sena, Arlene C AU - Naggie, Susanna AU - Frederick, Joyce AU - Engemann, John AU - Evans, Sharon AU - Pien, Brian C AU - Banerjee, Shailendra N AU - Engel, Jeffery AU - McDonald, LClifford AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, and the Epidemic Intelligence Service, Division of Applied Public Health Training, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, CMcDonald1@cdc.gov. Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 197 EP - 202 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Diarrhea KW - Catchment areas KW - Feces KW - Toxins KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21042633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Assessment+of+Clostridium+difficile-Associated+Disease+Surveillance+Definitions%2C+North+Carolina%2C+2005&rft.au=Kutty%2C+Preeta+K%3BBenoit%2C+Stephen+R%3BWoods%2C+Christopher+W%3BSena%2C+Arlene+C%3BNaggie%2C+Susanna%3BFrederick%2C+Joyce%3BEngemann%2C+John%3BEvans%2C+Sharon%3BPien%2C+Brian+C%3BBanerjee%2C+Shailendra+N%3BEngel%2C+Jeffery%3BMcDonald%2C+LClifford&rft.aulast=Kutty&rft.aufirst=Preeta&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F528813 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diarrhea; Catchment areas; Feces; Toxins; Hospitals; Clostridium DO - http://dx.doi.org/10.1086/528813 ER - TY - JOUR T1 - Intracellular Organic Osmolytes: Function and Regulation AN - 20892389; 8086720 AB - Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines. JF - Journal of Biological Chemistry AU - Burg, Maurice B AU - Ferraris, Joan D AD - Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 7309 EP - 7313 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 12 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Salts KW - Archaea KW - Plant protection KW - Reviews KW - Methylamine KW - Urea KW - Osmotic pressure KW - Signal transduction KW - J 02320:Cell Biology KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Intracellular+Organic+Osmolytes%3A+Function+and+Regulation&rft.au=Burg%2C+Maurice+B%3BFerraris%2C+Joan+D&rft.aulast=Burg&rft.aufirst=Maurice&rft.date=2008-03-01&rft.volume=283&rft.issue=12&rft.spage=7309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Salts; Plant protection; Reviews; Methylamine; Urea; Osmotic pressure; Signal transduction; Archaea ER - TY - JOUR T1 - Diploposthe laevis (Bloch) Jacobi (Eucestoda, Hymenolepididae) from Netta peposaca (Vieillot) (Aves: Anatidae): first record for the Neotropical Region and a new host AN - 20889782; 8236600 AB - One hundred eight rosy-billed pochards, Netta peposaca (Vieillot, 1816), collected in Brazil and Argentina were examined for endoparasites. Collection sites included the municipalities of Santa Vitoria do Palmar and Jaguarao, Rio Grande do Sul State, Brazil (wintering site) and Alvear, Corrientes Province, northern Argentina (nesting site). Birds were frozen in dry ice after collection. During necropsy they were categorized according to sex and maturation, either adult or juvenile. The cestode Diploposthe laevis (Bloch) Jacobi, 1896 was found (prevalence 68.5%, mean infection was 2). The mean prevalence of D. laevis in Alvear (25.9%) was higher than found in Jaguarao and Santa Vitoria do Palmar, Rio Grande do Sul (19%), and could be related to the nesting site and to the period when the birds may ingest a higher amount of food. This is the first record of a species of the genus Diploposthe in anatideans from South America, and the first record of the species in N. peposaca. Details of the cirrus pouch and vagina were described based on histological sections. JF - Revista Brasileira de Zoologia AU - Silveira, Eliane FDa AU - Amato, Suzana B Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 83 EP - 88 PB - Sociedade Brasileira de Zoologia, Caixa Postal 19020 Curitiba Parana 81531-990 Brazil, [mailto:sbz@bio.ufpr.br] VL - 25 IS - 1 SN - 0101-8175, 0101-8175 KW - Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Argentina KW - Brazil KW - migratory flyway KW - nesting site KW - rosy-billed pochard KW - wintering site * KW - New records KW - Autopsy KW - Neotropical Region KW - Eucestoda KW - Overwintering KW - Brazil, Rio Grande do Sul KW - Food KW - Anatidae KW - Infection KW - Endoparasites KW - Aves KW - Nesting KW - Sexual maturity KW - Vagina KW - Netta peposaca KW - Argentina, Corrientes KW - Reproductive behaviour KW - Hymenolepididae KW - Cestoda KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20889782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revista+Brasileira+de+Zoologia&rft.atitle=Diploposthe+laevis+%28Bloch%29+Jacobi+%28Eucestoda%2C+Hymenolepididae%29+from+Netta+peposaca+%28Vieillot%29+%28Aves%3A+Anatidae%29%3A+first+record+for+the+Neotropical+Region+and+a+new+host&rft.au=Silveira%2C+Eliane+FDa%3BAmato%2C+Suzana+B&rft.aulast=Silveira&rft.aufirst=Eliane&rft.date=2008-03-01&rft.volume=25&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Revista+Brasileira+de+Zoologia&rft.issn=01018175&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - New records; Overwintering; Sexual maturity; Nesting; Reproductive behaviour; Endoparasites; Autopsy; Food; Vagina; Infection; Aves; Eucestoda; Anatidae; Netta peposaca; Hymenolepididae; Cestoda; Neotropical Region; Argentina; Brazil, Rio Grande do Sul; Argentina, Corrientes ER - TY - JOUR T1 - Altered Utilization of N-Acetyl-D-Galactosamine by Escherichia coli O157:H7 from the 2006 Spinach Outbreak AN - 20860647; 8038197 AB - In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete coding sequences for enzyme IIA (EIIA) super(Aga/Gam), EIIB super(Aga), EIIC super(Aga), and EIID super(Aga) of the Aga PTS are present, E. coli O157:H7 strains normally are able to utilize Aga as a sole carbon source. The Gam PTS complex, in contrast, lacks EIIC super(Gam), and consequently, E. coli O157:H7 strains cannot utilize Gam. Phenotypic analyses of 120 independent isolates of E. coli O157:H7 from our culture collection revealed that the overwhelming majority (118/120) displayed the expected Aga super(+) Gam super(-) phenotype. Yet, when 194 individual isolates, derived from a 2006 spinach-associated E. coli O157:H7 outbreak, were analyzed, all (194/194) displayed an Aga super(-) Gam super(-) phenotype. Comparison of aga/gam sequences from two spinach isolates with those of EDL933 and Sakai revealed a single nucleotide change (G:C arrow right A:T) in the agaF gene in the spinach-associated isolates. The base substitution in agaF, which encodes EIIA super(Aga/Gam) of the PTS, changes a conserved glycine residue to serine (Gly91Ser). Pyrosequencing of this region showed that all spinach-associated E. coli O157:H7 isolates harbored this same G:C arrow right A:T substitution. Notably, when agaF super(+) was cloned into an expression vector and transformed into six spinach isolates, all (6/6) were able to grow on Aga, thus demonstrating that the Gly91Ser substitution underlies the Aga super(-) phenotype in these isolates. JF - Journal of Bacteriology AU - Mukherjee, Amit AU - Mammel, Mark K AU - LeClerc, JEugene AU - Cebula, Thomas A AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1710 EP - 1717 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 5 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Glycine KW - Enzymes KW - phosphotransferase KW - Carbon sources KW - D-Galactosamine KW - Expression vectors KW - Gene clusters KW - Escherichia coli KW - Culture collections KW - Spinacia oleracea KW - N-Acetyl-D-galactosamine KW - Serine KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Altered+Utilization+of+N-Acetyl-D-Galactosamine+by+Escherichia+coli+O157%3AH7+from+the+2006+Spinach+Outbreak&rft.au=Mukherjee%2C+Amit%3BMammel%2C+Mark+K%3BLeClerc%2C+JEugene%3BCebula%2C+Thomas+A&rft.aulast=Mukherjee&rft.aufirst=Amit&rft.date=2008-03-01&rft.volume=190&rft.issue=5&rft.spage=1710&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Glycine; Gene clusters; Culture collections; Enzymes; Carbon sources; phosphotransferase; D-Galactosamine; N-Acetyl-D-galactosamine; Serine; Escherichia coli; Spinacia oleracea ER - TY - JOUR T1 - Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice AN - 20809303; 8085035 AB - Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs). In order to evaluate the role of hepatic versus extra-hepatic metabolism of BaP and its pharmacokinetics, we used the hepatic cytochrome P450 reductase null (HRN) mouse model, in which cytochrome P450 oxidoreductase, the unique electron donor to CYPs, is deleted specifically in hepatocytes, resulting in the loss of essentially all hepatic CYP function. HRN and wild-type (WT) mice were treated intraperitoneally (i.p.) with 125 mg/kg body wt BaP daily for up to 5 days. Clearance of BaP from blood was analysed by high-performance liquid chromatography with fluorescence detection. DNA adduct levels were measured by super(32)P-post-labelling analysis with structural confirmation of the formation of 10-(deoxyguanosin-N super(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobe nzo[a]pyrene by liquid chromatography-tandem mass spectrometry analysis. Hepatic microsomes isolated from BaP-treated and untreated mice were also incubated with BaP and DNA in vitro. BaP-DNA adduct formation was up to 7-fold lower with the microsomes from HRN mice than with that from WT mice. Most of the hepatic microsomal activation of BaP in vitro was attributable to CYP1A. Pharmacokinetic analysis of BaP in blood revealed no significant differences between HRN and WT mice. BaP-DNA adduct levels were higher in the livers (up to 13-fold) and elevated in several extra-hepatic tissues of HRN mice (by 1.7- to 2.6-fold) relative to WT mice. These data reveal an apparent paradox, whereby hepatic CYP enzymes appear to be more important for detoxification of BaP in vivo, despite being involved in its metabolic activation in vitro. JF - Carcinogenesis AU - Arlt, Volker M AU - Stiborova, Marie AU - Henderson, Colin J AU - Thiemann, Markus AU - Frei, Eva AU - Aimova, Dagmar AU - Singh, Rajinder AU - Gamboa da Costa, Goncalo AU - Schmitz, Oliver J AU - Farmer, Peter B AU - Wolf, CRoland AU - Phillips, David H AD - Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic. Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Dundee DD1 9SY, UK. Department of Analytical Chemistry, University of Wuppertal, D-42119 Wuppertal, Germany. Division of Molecular Toxicology, German Cancer Research Center, D-69126 Heidelberg, Germany. Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, UK. Present address: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 656 EP - 665 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 29 IS - 3 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Detoxification KW - High-performance liquid chromatography KW - DNA adducts KW - Microsomes KW - Polycyclic aromatic hydrocarbons KW - Fluorescence KW - Data processing KW - Hepatocytes KW - Animal models KW - Enzymes KW - Pharmacokinetics KW - Mass spectroscopy KW - Blood KW - NADPH-ferrihemoprotein reductase KW - reductase KW - Carcinogenesis KW - Liver KW - Metabolic activation KW - oxidoreductase KW - Benzo(a)pyrene KW - Cytochrome P450 KW - N 14820:DNA Metabolism & Structure KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20809303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolic+activation+of+benzo%5Ba%5Dpyrene+in+vitro+by+hepatic+cytochrome+P450+contrasts+with+detoxification+in+vivo%3A+experiments+with+hepatic+cytochrome+P450+reductase+null+mice&rft.au=Arlt%2C+Volker+M%3BStiborova%2C+Marie%3BHenderson%2C+Colin+J%3BThiemann%2C+Markus%3BFrei%2C+Eva%3BAimova%2C+Dagmar%3BSingh%2C+Rajinder%3BGamboa+da+Costa%2C+Goncalo%3BSchmitz%2C+Oliver+J%3BFarmer%2C+Peter+B%3BWolf%2C+CRoland%3BPhillips%2C+David+H&rft.aulast=Arlt&rft.aufirst=Volker&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Detoxification; DNA adducts; Polycyclic aromatic hydrocarbons; Microsomes; Data processing; Fluorescence; Hepatocytes; Animal models; Enzymes; Mass spectroscopy; Pharmacokinetics; Blood; NADPH-ferrihemoprotein reductase; reductase; Carcinogenesis; Liver; oxidoreductase; Metabolic activation; Benzo(a)pyrene; Cytochrome P450 ER - TY - JOUR T1 - Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense AN - 20771814; 8039745 AB - Liver X receptor (LXR) alpha and beta are members of the nuclear receptor superfamily of ligand-activated transcription factors. Best known for triggering "reverse cholesterol transport" gene programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in regulation of innate immunity. In this study, we define a role for LXRs in regulation of pulmonary inflammation and host defense and identify the lung and neutrophil as novel in vivo targets for pharmacologic LXR activation. LXR is expressed in murine alveolar macrophages, alveolar epithelial type II cells, and neutrophils. Treatment of mice with TO-901317, a synthetic LXR agonist, reduces influx of neutrophils to the lung triggered by inhaled LPS, intratracheal KC chemokine, and intratracheal Klebsiella pneumoniae and impairs pulmonary host defense against this bacterium. Pharmacologic LXR activation selectively modulates airspace cytokine expression induced by both LPS and K. pneumoniae. Moreover, we report for the first time that LXR activation impairs neutrophil motility and identify inhibition of chemokine-induced RhoA activation as a putative underlying mechanism. Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung. JF - Journal of Immunology AU - Smoak, Kathleen AU - Madenspacher, Jennifer AU - Jeyaseelan, Samithamby AU - Williams, Belinda AU - Dixon, Darlene AU - Poch, Katie R AU - Nick, Jerry A AU - Worthen, GScott AU - Fessler, Michael B AD - Laboratory of Respiratory Biology and Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709. Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 3305 EP - 3312 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 5 SN - 0022-1767, 0022-1767 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Chemokines KW - Nuclear receptors KW - Leukocytes (neutrophilic) KW - Immunity KW - Cholesterol KW - Alveoli KW - Inflammation KW - Cell activation KW - RhoA protein KW - Motility KW - liver X receptors KW - Lung KW - Transcription factors KW - Cytokines KW - Lipopolysaccharides KW - Trachea KW - Klebsiella pneumoniae KW - N 14835:Protein-Nucleic Acids Association KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20771814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Effects+of+Liver+X+Receptor+Agonist+Treatment+on+Pulmonary+Inflammation+and+Host+Defense&rft.au=Smoak%2C+Kathleen%3BMadenspacher%2C+Jennifer%3BJeyaseelan%2C+Samithamby%3BWilliams%2C+Belinda%3BDixon%2C+Darlene%3BPoch%2C+Katie+R%3BNick%2C+Jerry+A%3BWorthen%2C+GScott%3BFessler%2C+Michael+B&rft.aulast=Smoak&rft.aufirst=Kathleen&rft.date=2008-03-01&rft.volume=180&rft.issue=5&rft.spage=3305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Chemokines; Nuclear receptors; Leukocytes (neutrophilic); Cholesterol; Immunity; Alveoli; RhoA protein; Cell activation; Inflammation; Motility; Lung; liver X receptors; Transcription factors; Lipopolysaccharides; Cytokines; Trachea; Klebsiella pneumoniae ER - TY - JOUR T1 - Clarification of FDA and The Joint Commission reporting requirements for US tissue recipient adverse reactions AN - 20768684; 8155670 JF - Cell and Tissue Banking AU - Khoie, Tina AU - Zinderman, Craig E AU - Solomon, Ruth AU - Wise, Robert P AU - Lee, Karen C AU - Nether, Klaus AD - Center for Biologics Evaluation and Research, Rockville, MD, USA, tina.khoie@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 67 EP - 68 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 9 IS - 1 SN - 1389-9333, 1389-9333 KW - Federal drug administration KW - Biotechnology and Bioengineering Abstracts KW - Tissues KW - Transplantation KW - Side effects KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20768684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+and+Tissue+Banking&rft.atitle=Clarification+of+FDA+and+The+Joint+Commission+reporting+requirements+for+US+tissue+recipient+adverse+reactions&rft.au=Khoie%2C+Tina%3BZinderman%2C+Craig+E%3BSolomon%2C+Ruth%3BWise%2C+Robert+P%3BLee%2C+Karen+C%3BNether%2C+Klaus&rft.aulast=Khoie&rft.aufirst=Tina&rft.date=2008-03-01&rft.volume=9&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Cell+and+Tissue+Banking&rft.issn=13899333&rft_id=info:doi/10.1007%2Fs10561-007-9043-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tissues; Transplantation; Side effects DO - http://dx.doi.org/10.1007/s10561-007-9043-2 ER - TY - JOUR T1 - Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort AN - 20762472; 8083992 AB - Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m@@u2@ were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of ^.35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; p@@dtrend@ = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI ^.35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; p@@dtrend@ = 0.004) but not recent smokers (p@@dinteraction@ = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; p@@dtrend@ = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer. JF - American Journal of Epidemiology AU - Stolzenberg-Solomon, Rachael Z AU - Adams, Kenneth AU - Leitzmann, Michael AU - Schairer, Catherine AU - Michaud, Dominique S AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Silverman, Debra T AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 586 EP - 597 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Physical Education Index KW - Waist KW - Body mass KW - Surveys KW - Health KW - Diet KW - Exercise KW - Hips KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Adiposity%2C+Physical+Activity%2C+and+Pancreatic+Cancer+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Cohort&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BAdams%2C+Kenneth%3BLeitzmann%2C+Michael%3BSchairer%2C+Catherine%3BMichaud%2C+Dominique+S%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSilverman%2C+Debra+T&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Body mass; Exercise; Health; Waist; Diet; Surveys; Hips ER - TY - JOUR T1 - Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland) AN - 20729280; 8085076 AB - Extending research on the protective effect of flavonoids in cell culture and animal studies, we examined the association between consumption of flavonoids and flavonoid-rich foods and development of exocrine pancreatic cancer within the alpha -Tocopherol, beta -Carotene Cancer Prevention Study cohort. Of the 27,111 healthy male smokers (50-69 years) who completed a self-administered dietary questionnaire at baseline, 306 developed exocrine pancreatic cancer during follow-up (1985-2004; median, 16.1 years). Intakes of total flavonoids, three flavonoid subgroups, seven individual flavonoids, and flavonoid-rich foods were estimated from a validated food frequency questionnaire. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. Overall, flavonoid intake was not significantly associated with pancreatic cancer. However, in stratified analysis, greater total flavonoid intake was associated with decreased pancreatic cancer risk in participants randomized during the trial to placebo (fourth versus first quartile: hazard ratio, 0.36; 95% confidence interval, 0.17-0.78; P sub(trend) = 0.009) and not to supplemental alpha -tocopherol (50 mg/d) and/or beta -carotene (20 mg/d; P sub(interaction) = 0.002). Similar patterns and significant interactions were observed for flavonols, flavan-3-ols, kaempferol, quercetin, catechin, and epicatechin. Our data suggest that a flavonoid-rich diet may decrease pancreatic cancer risk in male smokers not consuming supplemental alpha -tocopherol and/or beta -carotene. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):553-62) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Bobe, Gerd AU - Weinstein, Stephanie J AU - Albanes, Demetrius AU - Hirvonen, Tero AU - Ashby, Jason AU - Taylor, Phil R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael Z AD - Nutritional Epidemiology Branch and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 553 EP - 562 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - Diets KW - pancreatic cancer KW - Finland KW - prevention KW - males KW - Cancer KW - flavonoids KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Flavonoid+Intake+and+Risk+of+Pancreatic+Cancer+in+Male+Smokers+%28Finland%29&rft.au=Bobe%2C+Gerd%3BWeinstein%2C+Stephanie+J%3BAlbanes%2C+Demetrius%3BHirvonen%2C+Tero%3BAshby%2C+Jason%3BTaylor%2C+Phil+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Bioindicators; pancreatic cancer; prevention; males; Cancer; flavonoids; Finland ER - TY - JOUR T1 - Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China AN - 20729161; 8085073 AB - Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):525-34) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Andreotti, Gabriella AU - Chen, Jinbo AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chen, Bingshu E AU - Rosenberg, Philip AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Fraumeni, Joseph FJr AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 525 EP - 534 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts KW - Lipids KW - Lipoprotein (low density) receptors KW - Gene polymorphism KW - Hyperlipidemia KW - Apolipoprotein E KW - Buffy coat KW - Malignancy KW - Haplotypes KW - Risk factors KW - prevention KW - Ampulla of Vater KW - population control KW - Bioindicators KW - Bile duct KW - Genotyping KW - haplotypes KW - biomarkers KW - Biliary tract KW - Cancer KW - Lipid metabolism KW - Gallbladder KW - Blood KW - Single-nucleotide polymorphism KW - DNA KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Metabolism KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+of+Genes+in+the+Lipid+Metabolism+Pathway+and+Risk+of+Biliary+Tract+Cancers+and+Stones%3A+A+Population-Based+Case-Control+Study+in+Shanghai%2C+China&rft.au=Andreotti%2C+Gabriella%3BChen%2C+Jinbo%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BFraumeni%2C+Joseph+FJr%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bile duct; Genotyping; Gene polymorphism; Lipoprotein (low density) receptors; Apolipoprotein E; Hyperlipidemia; Buffy coat; biomarkers; Cancer; Biliary tract; Lipid metabolism; Blood; Gallbladder; Malignancy; Haplotypes; Single-nucleotide polymorphism; Risk factors; DNA; Ampulla of Vater; Bioindicators; Lipids; prevention; haplotypes; population control; Metabolism; China, People's Rep., Shanghai; China, People's Rep. ER - TY - JOUR T1 - Dietary Fiber, Lung Function, and Chronic Obstructive Pulmonary Disease in the Atherosclerosis Risk in Communities Study AN - 20727499; 8083990 AB - Recent data suggest beneficial effects of fiber intake on chronic respiratory symptoms in adults that are independent of antioxidant vitamin intake, but little is known about fiber consumption in relation to lung function and chronic obstructive pulmonary disease (COPD). The authors investigated the association of fiber intake with lung function and COPD in 11,897 US men and women from the Atherosclerosis Risk in Communities study (1987-1989). After control for potential confounders, positive associations were found between lung function and fiber intake from all sources as well as from cereal or fruit alone. Compared with those in the lowest quintile, participants in the highest quintile of total fiber intake had a 60.2-ml higher forced expiratory volume in 1 second (FEV sub(1)) (p for trend < 0.001), 55.2-ml higher forced vital capacity (FVC) (p = 0.001), 0.4% higher FEV sub(1)/FVC ratio (p = 0.040), 1.8% higher percent predicted FEV sub(1) (p < 0.001), and 1.4% higher percent predicted FVC (p = 0.001). Adjusted odds ratios of COPD for the highest versus lowest quintiles of intake were 0.85 (p = 0.044) for total fiber, 0.83 (p = 0.021) for cereal fiber, and 0.72 (p = 0.005) for fruit fiber. This study provides the first known evidence that dietary fiber is independently associated with better lung function and reduced prevalence of COPD. JF - American Journal of Epidemiology AU - Kan, Haidong AU - Stevens, June AU - Heiss, Gerardo AU - Rose, Kathryn M AU - London, Stephanie J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 570 EP - 578 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - Antioxidants KW - fruits KW - Fibers KW - vitamins KW - Respiratory function KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Dietary+Fiber%2C+Lung+Function%2C+and+Chronic+Obstructive+Pulmonary+Disease+in+the+Atherosclerosis+Risk+in+Communities+Study&rft.au=Kan%2C+Haidong%3BStevens%2C+June%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fibers; Respiratory function; Diets; fruits; chronic obstructive pulmonary disease; vitamins; Antioxidants ER - TY - JOUR T1 - Risk of Testicular Germ Cell Tumors and Polymorphisms in the Insulin-Like Growth Factor Genes AN - 20726905; 8085099 AB - Because taller men are at increased risk of developing testicular germ cell tumors (TGCT), it is conceivable that factors that influence adult height could be related to risk of TGCT. Because common genetic variation in genes of the insulin-like growth factor (IGF) pathway could influence somatic growth, 43 single nucleotide polymorphisms in four IGF genes (IGF-1, IGF-1R, IGF-2, and IGFALS) were genotyped in 577 case and 707 control participants from the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study to assess relationships with TGCT risk; additionally, associations between polymorphisms and adult height were examined. Relationships between polymorphisms and adult height were assessed using adjusted linear regression models, and associations between polymorphisms and TGCT risk were determined by adjusted logistic regression models estimating odds ratios. Although four IGF-1R polymorphisms (rs907806, rs3743258, rs229765, and rs9282714) were associated with height (P sub(trend) < 0.05), there were no relationships with any other polymorphism. Overall, there were no associations among polymorphisms or haplotypes in the IGF genes and TGCT risk, with odds ratios ranging from 0.55 to 1.50. Similarly, there was no association among the polymorphisms and risk of specific TGCT histologies (seminoma and nonseminoma). There was a suggestion, however, that adult height may modify the relationship between an IGF-1 haplotype and TGCT risk. These results suggest that, in aggregate, genetic variation in IGF loci is not associated with TGCT risk. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):721-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chia, Victoria M AU - Sakoda, Lori C AU - Graubard, Barry I AU - Rubertone, Mark V AU - Chanock, Stephen J AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 721 EP - 726 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Testes KW - Body height KW - Gene polymorphism KW - Bone growth KW - Genetic diversity KW - tumors KW - Haplotypes KW - prevention KW - Regression analysis KW - growth factors KW - Bioindicators KW - Insulin-like growth factor I KW - Germ cells KW - genetic diversity KW - haplotypes KW - Tumors KW - biomarkers KW - Cancer KW - USA KW - Histology KW - Single-nucleotide polymorphism KW - Insulin-like growth factors KW - seminoma KW - B 26600:Tyrosine Kinase Activity KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Risk+of+Testicular+Germ+Cell+Tumors+and+Polymorphisms+in+the+Insulin-Like+Growth+Factor+Genes&rft.au=Chia%2C+Victoria+M%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BRubertone%2C+Mark+V%3BChanock%2C+Stephen+J%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Chia&rft.aufirst=Victoria&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Insulin-like growth factor I; Body height; Gene polymorphism; Bone growth; Germ cells; Genetic diversity; Tumors; biomarkers; Cancer; Haplotypes; Single-nucleotide polymorphism; Insulin-like growth factors; Regression analysis; seminoma; Bioindicators; Histology; prevention; genetic diversity; tumors; haplotypes; growth factors; USA ER - TY - JOUR T1 - Anthrax Lethal Toxin Increases Superoxide Production in Murine Neutrophils via Differential Effects on MAPK Signaling Pathways AN - 20706974; 8087451 AB - The combination of lethal factor and its receptor-binding partner, protective Ag, is termed lethal toxin (LT) and has critical pathogenic activity during infection with Bacillus anthracis. We herein report that anthrax LT binds and enters murine neutrophils, leading to the cleavage of mitogen-activated protein kinase kinase/MEK/MAPKK 1-4 and 6, but not mitogen-activated protein kinase kinase 5 and 7. Anthrax LT treatment of neutrophils disrupts signaling to downstream MAPK targets in response to TLR stimulation. Following anthrax LT treatment, ERK family and p38 phosphorylation are nearly completely blocked, but signaling to JNK family members persists in vitro and ex vivo. In contrast to previous reports involving human neutrophils, anthrax LT treatment of murine neutrophils increases their production of superoxide in response to PMA or TLR stimulation in vitro or ex vivo. Although this enhanced superoxide production correlates with effects due to the LT-induced blockade of ERK signaling, it requires JNK signaling that remains largely intact despite the activity of anthrax LT. These findings reveal a previously unrecognized mechanism through which anthrax LT supports a critical proinflammatory response of murine neutrophils. JF - Journal of Immunology AU - Xu, Lixin AU - Fang, Hui AU - Frucht, David M AD - Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4139 EP - 4147 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 6 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anthrax lethal toxin KW - MAP kinase KW - Phorbol esters KW - c-Jun amino-terminal kinase KW - Lethal factor KW - Leukocytes (neutrophilic) KW - Bacillus anthracis KW - Infection KW - Inflammation KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Superoxide KW - Anthrax KW - Signal transduction KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20706974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Anthrax+Lethal+Toxin+Increases+Superoxide+Production+in+Murine+Neutrophils+via+Differential+Effects+on+MAPK+Signaling+Pathways&rft.au=Xu%2C+Lixin%3BFang%2C+Hui%3BFrucht%2C+David+M&rft.aulast=Xu&rft.aufirst=Lixin&rft.date=2008-03-01&rft.volume=180&rft.issue=6&rft.spage=4139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; MAP kinase; c-Jun amino-terminal kinase; Phorbol esters; Lethal factor; Leukocytes (neutrophilic); Infection; Inflammation; Extracellular signal-regulated kinase; Phosphorylation; Superoxide; Anthrax; Signal transduction; Bacillus anthracis ER - TY - JOUR T1 - Real-Time PCR Assays for Quantification and Differentiation of Vibrio vulnificus Strains in Oysters and Water AN - 20705235; 8083552 AB - Vibrio vulnificus is an autochthonous estuarine bacterium and a pathogen that is frequently transmitted via raw shellfish. Septicemia can occur within 24 h; however, isolation and confirmation from water and oysters require days. Real-time PCR assays were developed to detect and differentiate two 16S rRNA variants, types A and B, which were previously associated with environmental sources and clinical fatalities, respectively. Both assays could detect 10 super(2) to 10 super(3) V. vulnificus total cells in seeded estuarine water and in oyster homogenates. PCR assays on 11 reference V. vulnificus strains and 22 nontarget species gave expected results (type A or B for V. vulnificus and negative for nontarget species). The relationship between cell number and cycle threshold for the assays was linear (R super(2) = >0.93). The type A/B ratio of Florida clinical isolates was compared to that of isolates from oysters harvested in Florida waters. This ratio was 19:17 in clinical isolates and 5:8 (n = 26) in oysters harvested from restricted sites with poor water quality but was 10:1 (n = 22) in oysters from permitted sites with good water quality. A substantial percentage of isolates from oysters (19.4%) were type AB (both primer sets amplified), but no isolates from overlying waters were type AB. The real-time PCR assays were sensitive, specific, and quantitative in water samples and could also differentiate the strains in oysters without requiring isolation of V. vulnificus and may therefore be useful for rapid detection of the pathogen in shellfish and water, as well as further investigation of its population dynamics. JF - Applied and Environmental Microbiology AU - Gordon, Katrina V AU - Vickery, Michael C AU - DePaola, Angelo AU - Staley, Christopher AU - Harwood, Valerie J AD - Department of Biology, University of South Florida, Tampa, Florida 33620. BioGX, Inc., Birmingham, Alabama 35203. Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528 Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 1704 EP - 1709 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 6 SN - 0099-2240, 0099-2240 KW - Pollution Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - water quality KW - Water sampling KW - Septicemia KW - Nucleotide sequence KW - Population dynamics KW - Water quality KW - Public health KW - Disease transmission KW - Differentiation KW - oysters KW - Vibrio vulnificus KW - Polymerase chain reaction KW - Clinical isolates KW - ASW, USA, Florida KW - Mortality KW - Cell number KW - Pathogenic bacteria KW - Estuaries KW - Brackish KW - Assays KW - Pathogens KW - Antibodies KW - DNA KW - Water wells KW - Marine molluscs KW - Shellfish KW - Primers KW - rRNA 16S KW - J 02410:Animal Diseases KW - P 2000:FRESHWATER POLLUTION KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08484:Species interactions: parasites and diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20705235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Real-Time+PCR+Assays+for+Quantification+and+Differentiation+of+Vibrio+vulnificus+Strains+in+Oysters+and+Water&rft.au=Gordon%2C+Katrina+V%3BVickery%2C+Michael+C%3BDePaola%2C+Angelo%3BStaley%2C+Christopher%3BHarwood%2C+Valerie+J&rft.aulast=Gordon&rft.aufirst=Katrina&rft.date=2008-03-01&rft.volume=74&rft.issue=6&rft.spage=1704&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Nucleotide sequence; Estuaries; DNA; Marine molluscs; Water quality; Disease transmission; Public health; Clinical isolates; Differentiation; Antibodies; Septicemia; Cell number; Polymerase chain reaction; Primers; Pathogens; Population dynamics; rRNA 16S; Mortality; water quality; oysters; Water sampling; Water wells; Assays; Shellfish; Vibrio vulnificus; ASW, USA, Florida; Brackish ER - TY - JOUR T1 - Ciprofloxacin-Resistant Salmonella enterica Serotype Typhimurium, China AN - 20334319; 9015097 AB - We characterized 44 Salmonella enterica serotype Typhimurium isolates from Tongji Hospital outpatients in Wuhan, China, May 2002-October 2005. All 31 ciprofloxacin-resistant isolates were also resistant to > 8 other antimicrobial drugs and carried > 2 mutations in GyrA and 1 mutation in ParC. Class 1 integrons were identified in 37 isolates. JF - Emerging Infectious Diseases AU - Cui, Shenghui AU - Li, Jingyun AU - Sun, Ziyong AU - Hu, Changqin AU - Jin, Shaohong AU - Guo, Yunchang AU - Ran, Lu AU - Ma, Yue AD - * State Food and Drug Administration, Beijing, People's Republic of China Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 493 EP - 495 PB - U.S. National Center for Infectious Diseases, 1600 Clifton Rd VL - 14 IS - 3 SN - 1080-6040, 1080-6040 KW - Microbiology Abstracts B: Bacteriology KW - Salmonella Typhimurium KW - outpatients KW - ciprofloxacin KW - resistance KW - dispatch KW - Serotypes KW - Salmonella enterica KW - Mutation KW - Drugs KW - DNA topoisomerase IV KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20334319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Ciprofloxacin-Resistant+Salmonella+enterica+Serotype+Typhimurium%2C+China&rft.au=Cui%2C+Shenghui%3BLi%2C+Jingyun%3BSun%2C+Ziyong%3BHu%2C+Changqin%3BJin%2C+Shaohong%3BGuo%2C+Yunchang%3BRan%2C+Lu%3BMa%2C+Yue&rft.aulast=Cui&rft.aufirst=Shenghui&rft.date=2008-03-01&rft.volume=14&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/10.3201%2Feid1403.070857 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Serotypes; Drugs; Mutation; DNA topoisomerase IV; Hospitals; Salmonella enterica DO - http://dx.doi.org/10.3201/eid1403.070857 ER - TY - JOUR T1 - Adverse effects of fullerenes on endothelial cells: Fullerenol C sub(60)(OH) sub(24) induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro AN - 20219173; 10289623 AB - We studied the effects of a C sub(60) water suspension at 4 I14g/mL (nC sub(60)) and the water soluble fullerenol C sub(60)(OH) sub(24) at final concentrations of 1 super(a)100 I14g/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C sub(60)(OH) sub(24) at 100 I14g/mL significantly increased cell surface expression of ICAM-1(CD54) (67 A- 4% CD54 super(+) cells vs. 19 A- 2 % CD54 super(+) cells in control; p & 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 A- 20% CD142 super(+) cells vs 4 A- 2% CD142 super(+) cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 A- 2% PS super(+) cells vs. 12 A- 5% PS super(+) cells in control; p & 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC sub(60) and C sub(60)(OH) sub(24) caused G1 arrest of HUVECs and C sub(60)(OH) sub(24) induced significant apoptosis (21 A- 2% TUNEL super(+) cells at 100 I14g/mL of C sub(60)(OH) sub(24) vs. 4 A- 2% TUNEL super(+) cells in control; p & 0.001). We also demonstrated that both nC sub(60) and C sub(60)(OH) sub(24) induced a rapid concentration dependent elevation of intracellular calcium [Ca super(2+)] sub(i). This could be inhibited by EGTA, suggesting that the source of [Ca super(2+)] sub(i) in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C sub(60)(OH) sub(24) had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium. JF - International Journal of Nanomedicine AU - Gelderman, Monique P AU - Simakova, Olga AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Siddiqui, Sheena F AU - Vostal, Alexander C AU - Simak, Jan AD - CBER, FDA Rockville, MD USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 59 EP - 68 PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL UK VL - 3 IS - 1 SN - 1176-9114, 1176-9114 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - endothelial cells KW - fullerenes KW - tissue factor KW - apoptosis KW - ICAM-1 KW - flow cytometry KW - Cell surface KW - Apoptosis KW - Tissue factor KW - Cell cycle KW - Cell culture KW - umbilical vein KW - Calcium (intracellular) KW - Inflammation KW - Endothelial cells KW - DNA fragmentation KW - phosphatidylserine KW - Fullerenes KW - Endothelium KW - intercellular adhesion molecule 1 KW - Side effects KW - nanotechnology KW - W 30940:Products KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20219173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nanomedicine&rft.atitle=Adverse+effects+of+fullerenes+on+endothelial+cells%3A+Fullerenol+C+sub%2860%29%28OH%29+sub%2824%29+induced+tissue+factor+and+ICAM-1+membrane+expression+and+apoptosis+in+vitro&rft.au=Gelderman%2C+Monique+P%3BSimakova%2C+Olga%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BSiddiqui%2C+Sheena+F%3BVostal%2C+Alexander+C%3BSimak%2C+Jan&rft.aulast=Gelderman&rft.aufirst=Monique&rft.date=2008-03-01&rft.volume=3&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Apoptosis; Tissue factor; Cell cycle; Cell culture; umbilical vein; Inflammation; Calcium (intracellular); Endothelial cells; DNA fragmentation; Fullerenes; phosphatidylserine; intercellular adhesion molecule 1; Endothelium; Side effects; nanotechnology ER - TY - JOUR T1 - Development of an Aerosol System for Uniformly Depositing Bacillus Anthracis Spore Particles on Surfaces AN - 20061312; 8589995 AB - After the anthrax incidents in October 2001, several techniques used for sampling surfaces for biological agents were found to be inadequately validated, especially at low surface loadings. Therefore a test chamber was developed to produce sample sets having targeted surface concentrations of dry biological agent simulant. Dry spore aerosols were initially dispersed into the chamber at relatively high air concentrations, and monitored in real time. The concentration decay (due to stirred settling and dilution) was measured and when the targeted air concentration was reached, the sampling surfaces were uncovered and exposed to the settling particles until >99% of the particles had settled. Multiple agar plates were used to estimate the true colony-forming-unit (CFU) surface concentration. The uniformity of surface loadings was limited by random deposition of small numbers of particles on the surfaces (Poisson distribution) and was characterized by how much greater the observed variability was than that predicted by Poisson statistics. The flow-enhanced powder mixture appeared to affect the spores' ability to grow on the agar medium. Three ways of analyzing the agar plates were used to evaluate the effect of spore coatings on viability and to differentiate between number of spore-containing particles and the number of spores. The presence of spore agglomerates re-suspended by various sample handling activities in the chamber further increased the variability of deposited particles. Based on estimated airborne particle concentration, it was possible to predict mean agar plate concentrations within narrow confidence intervals (CI) at low (4.8 CFU, 95% CI 3.5-6.4), medium (20 CFU, 95% CI 17-23), and high (160 CFU, 95% CI 140-190) concentrations. JF - Aerosol Science & Technology AU - Baron, Paul A AU - Estill, Cherie F AU - Deye, Gregory J AU - Hein, Misty J AU - Beard, Jeremy K AU - Larsen, Lloyd D AU - Dahlstrom, Gregory E AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 159 EP - 172 PB - Taylor & Francis, 325 Chestnut Street Suite 800 Philadelphia PA 19106 USA, [URL:http://www.taylorandfrancis.com/] VL - 42 IS - 3 SN - 0278-6826, 0278-6826 KW - Pollution Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Powder KW - Aerosols KW - Statistics KW - Particulates KW - anthrax KW - Bacillus anthracis KW - Pollutant deposition KW - Colony-forming cells KW - Anthrax KW - Decay KW - Sampling KW - Coatings KW - P 0000:AIR POLLUTION KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20061312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Development+of+an+Aerosol+System+for+Uniformly+Depositing+Bacillus+Anthracis+Spore+Particles+on+Surfaces&rft.au=Baron%2C+Paul+A%3BEstill%2C+Cherie+F%3BDeye%2C+Gregory+J%3BHein%2C+Misty+J%3BBeard%2C+Jeremy+K%3BLarsen%2C+Lloyd+D%3BDahlstrom%2C+Gregory+E&rft.aulast=Baron&rft.aufirst=Paul&rft.date=2008-03-01&rft.volume=42&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786820801918605 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Powder; Agar; Aerosols; Statistics; Colony-forming cells; Anthrax; Sampling; Coatings; Pollutant deposition; anthrax; Decay; Particulates; Bacillus anthracis DO - http://dx.doi.org/10.1080/02786820801918605 ER - TY - JOUR T1 - Mechanisms of Resistance to Daptomycin in Enterococcus faecium AN - 20026947; 8083395 AB - In this study, we investigated the clonal emergence of daptomycin-resistant Enterococcus faecium strains isolated from a patient with leukocyte adhesion deficiency syndrome. The resistance mechanism in these strains is independent of either equivalent point mutations previously described for Staphylococcus aureus or daptomycin inactivation mechanisms identified in soil bacteria. JF - Antimicrobial Agents & Chemotherapy AU - Montero, Clemente I AU - Stock, Frida AU - Murray, Patrick R AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1167 EP - 1170 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Leukocytes KW - Point mutation KW - Staphylococcus aureus KW - daptomycin KW - Enterococcus faecium KW - Soil microorganisms KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20026947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Mechanisms+of+Resistance+to+Daptomycin+in+Enterococcus+faecium&rft.au=Montero%2C+Clemente+I%3BStock%2C+Frida%3BMurray%2C+Patrick+R&rft.aulast=Montero&rft.aufirst=Clemente&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Point mutation; Leukocytes; daptomycin; Soil microorganisms; Staphylococcus aureus; Enterococcus faecium ER - TY - JOUR T1 - Enhanced Production of Phospholipase C and Perfringolysin O (Alpha and Theta Toxins) in a Gatifloxacin-Resistant Strain of Clostridium perfringens AN - 20013465; 8083419 AB - Clostridium perfringens-induced gas gangrene is mediated by potent extracellular toxins, especially alpha toxin (a phospholipase C [PLC]) and theta toxin (perfringolysin O [PFO], a thiol-activated cytolysin); and antibiotic-induced suppression of toxin synthesis is an important clinical goal. The production of PLC and PFO by a gatifloxacin-induced, fluoroquinolone-resistant mutant strain of C. perfringens, strain 10G, carrying a stable mutation in DNA gyrase was compared with that of the wild-type (WT) parent strain. Zymography (with sheep red blood cell and egg yolk overlays) and time course analysis [with hydrolysis of egg yolk lecithin and O-(4 nitrophenyl-phosphoryl)choline] demonstrated that strain 10G produced more PLC and PFO than the WT strain. Increased toxin production in strain 10G was not related either to differences in growth characteristics between the wild-type and the mutant strain or to nonsynonymous polymorphisms in PLC, PFO, or their known regulatory proteins. Increased PLC and PFO production by strain 10G was associated with increased cytotoxic activity for HT-29 human adenocarcinoma cells and with increased platelet-neutrophil aggregate formation. Four other gatifloxacin-induced gyrase mutants did not show increased toxin production, suggesting that gatifloxacin resistance was not always associated with increased toxin production in all strains of C. perfringens. This is the first report of increased toxin production in a fluoroquinolone-resistant strain of C. perfringens. JF - Antimicrobial Agents & Chemotherapy AU - Rafii, Fatemeh AU - Park, Miseon AU - Bryant, Amy E AU - Johnson, Shemedia J AU - Wagner, Robert D AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Veterans Affairs Medical Center, Boise, Idaho. University of Washington School of Medicine, Seattle, Washington Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 895 EP - 900 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Gas gangrene KW - Sheep red blood cells KW - Gene polymorphism KW - Phospholipase C KW - Clostridium perfringens KW - Lecithin KW - DNA topoisomerase KW - Hydrolysis KW - Gatifloxacin KW - Yolk KW - Toxin A KW - Cytotoxicity KW - regulatory proteins KW - cytolysins KW - Adenocarcinoma KW - Mutation KW - A 01360:Plant Diseases KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20013465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Enhanced+Production+of+Phospholipase+C+and+Perfringolysin+O+%28Alpha+and+Theta+Toxins%29+in+a+Gatifloxacin-Resistant+Strain+of+Clostridium+perfringens&rft.au=Rafii%2C+Fatemeh%3BPark%2C+Miseon%3BBryant%2C+Amy+E%3BJohnson%2C+Shemedia+J%3BWagner%2C+Robert+D&rft.aulast=Rafii&rft.aufirst=Fatemeh&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gas gangrene; Sheep red blood cells; Phospholipase C; Gene polymorphism; DNA topoisomerase; Lecithin; Hydrolysis; Yolk; Gatifloxacin; Toxin A; Cytotoxicity; cytolysins; regulatory proteins; Adenocarcinoma; Mutation; Clostridium; Clostridium perfringens ER - TY - JOUR T1 - Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective AN - 19902459; 8769357 AB - The use of lipid-based dosage forms for enhancement of drug absorption or delivery has drawn considerable interest from pharmaceutical scientists. The unique characteristics of these dosage forms, however, present significant challenges to pharmaceutical industry and regulatory agencies in many ways. For example, safety assessment is necessary when the use of a new lipid excipient is considered. An important question for lipid formulation is whether the drug remains in solubilised form along the gastrointestinal (GI) tract after it is administered. Certain lipid excipients and surfactants have been reported to change intestinal permeability or interfere with enzyme/transporter activity, thereby affecting drug bioavailability. The potential influence of biopharmaceutical and/or pathophysiological factors on the drug or lipid excipient(s) needs to be explored. For a complex lipid- based dosage form, the conventional in vitro dissolution methods may not be appropriate for predicting in vivo performance in view of the convoluted GI processing of the lipid vehicle and formulation Of paramount importance is to identify any gaps in the scientific understanding of lipid- based dosage forms so that regulatory issues can be addressed. More mechanistic studies should be encouraged to facilitate a better understanding of the pharmaceutical characteristics of lipid formulations and complex interactions between lipid excipient, drug and physiological environment. This review discusses some regulatory considerations in the use of lipid excipients and delivery systems for pharmaceutical development. Implications in the regulatory determination of pharmaceutical equivalence, bioequivalence and therapeutic equivalence are also illustrated. JF - Advanced Drug Delivery Reviews AU - Chen, Mei-Ling AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration 10903 New Hampshire Avenue, Building 21, Room. 3508 Silver Spring, MD 20993-0002, USA, meiling.chen@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 768 EP - 777 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 60 IS - 6 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Bioavailability KW - Permeability KW - Drug delivery KW - Lipids KW - Intestine KW - Dissolution KW - Enzymes KW - Pharmaceuticals KW - Gastrointestinal tract KW - Surfactants KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19902459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Lipid+excipients+and+delivery+systems+for+pharmaceutical+development%3A+A+regulatory+perspective&rft.au=Chen%2C+Mei-Ling&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2008-03-01&rft.volume=60&rft.issue=6&rft.spage=768&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.09.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Lipids; Pharmaceuticals; Drug delivery; Gastrointestinal tract; Surfactants; Enzymes; Intestine; Dissolution; Permeability; Bioavailability DO - http://dx.doi.org/10.1016/j.addr.2007.09.010 ER - TY - JOUR T1 - Non-Traditional Vectors for Paralytic Shellfish Poisoning AN - 19799666; 8523956 AB - Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, are also produced in freshwater cyanobacteria and have been associated with calcareous red macroalgae. STXs are transferred and bioaccumulate throughout aquatic food webs, and can be vectored to terrestrial biota, including humans. Fisheries closures and human intoxications due to STXs have been documented in several non-traditional (i.e. non-filter-feeding) vectors. These include, but are not limited to, marine gastropods, both carnivorous and grazing, crustacea, and fish that acquire STXs through toxin transfer. Often due to spatial, temporal, or a species disconnection from the primary source of STXs (bloom forming dinoflagellates), monitoring and management of such non-traditional PSP vectors has been challenging. A brief literature review is provided for filter feeding (traditional) and non-filter feeding (non-traditional) vectors of STXs with specific reference to human effects. We include several case studies pertaining to management actions to prevent PSP, as well as food poisoning incidents from STX(s) accumulation in non-traditional PSP vectors. JF - Marine Drugs AU - Deeds, Jonathan R AU - Landsberg, Jan H AU - Etheridge, Stacey M AU - Pitcher, Grant C AU - Longan, Sara Watt AD - US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland, 20723, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 308 EP - 348 PB - Molecular Diversity Preservation International, Matthaeusstr 11 VL - 6 IS - 2 SN - 1660-3397, 1660-3397 KW - Gastropods KW - Mollusks KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - Intoxication KW - Algal blooms KW - grazing KW - Toxicants KW - feeding KW - Phytoplankton KW - Public health KW - Biota KW - intoxication KW - Fisheries KW - Saxitoxin KW - Dinoflagellates KW - Mollusca KW - food webs KW - Drugs KW - Paralytic shellfish poisoning KW - Food webs KW - Feeding KW - Freshwater environments KW - Grazing KW - Crustacea KW - Gastropoda KW - Poisoning KW - Food poisoning KW - Food contamination KW - Toxins KW - case studies KW - Filters KW - Cyanobacteria KW - Bioaccumulation KW - Reviews KW - Fish KW - Shellfish KW - Cyanophyta KW - Q4 27740:Products KW - Q1 08482:Ecosystems and energetics KW - K 03450:Ecology KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19799666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Drugs&rft.atitle=Non-Traditional+Vectors+for+Paralytic+Shellfish+Poisoning&rft.au=Deeds%2C+Jonathan+R%3BLandsberg%2C+Jan+H%3BEtheridge%2C+Stacey+M%3BPitcher%2C+Grant+C%3BLongan%2C+Sara+Watt&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2008-03-01&rft.volume=6&rft.issue=2&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Marine+Drugs&rft.issn=16603397&rft_id=info:doi/10.3390%2Fmd20080015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Algal blooms; Bioaccumulation; Toxicants; Food poisoning; Phytoplankton; Food webs; Paralytic shellfish poisoning; Public health; Intoxication; Feeding; Grazing; Freshwater environments; Toxins; Filters; Reviews; Fisheries; Dinoflagellates; Saxitoxin; grazing; feeding; Poisoning; Food contamination; case studies; intoxication; Biota; Shellfish; Fish; Drugs; food webs; Cyanobacteria; Gastropoda; Crustacea; Mollusca; Cyanophyta DO - http://dx.doi.org/10.3390/md20080015 ER - TY - JOUR T1 - Survey of furan in heat processed foods by headspace gas chromatography/mass spectrometry and estimated adult exposure AN - 19339885; 8681825 AB - Furan is a suspected human carcinogen that is formed in some processed foods at low ng per g levels. Recent improvements in analytical methodology and scientific instrumentation have made it possible to accurately measure the amount of furan in a wide variety of foods. Results from analysis of more than 300 processed foods are presented. Furan was found at levels ranging from non-detectable (LOD, 0.2-0.9 ng g-1) to over 100 ng g-1. Exposure estimates for several adult food types were calculated, with brewed coffee being the major source of furan in the adult diet (0.15 mg kg-1 body weight day-1). Estimates of mean exposure to furan for different subpopulations were calculated. For consumers 2 years and older, the intake is estimated to be about 0.2 mg kg-1 body weight day-1. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Morehouse, Kim M AU - Nyman, Patricia J AU - McNeal, Timothy P AU - Dinovi, Michael J AU - Perfetti, Gracia A AD - Food and Drug Administration-CFSAN, College Park, MD 20740, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 259 EP - 264 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3 SN - 0265-203X, 0265-203X KW - Risk Abstracts KW - Risk assessment KW - Diets KW - coffee KW - Mass spectrometry KW - Carcinogens KW - Furans KW - Food additives KW - subpopulations KW - Gas chromatography KW - body weight UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19339885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+furan+in+heat+processed+foods+by+headspace+gas+chromatography%2Fmass+spectrometry+and+estimated+adult+exposure&rft.au=Morehouse%2C+Kim+M%3BNyman%2C+Patricia+J%3BMcNeal%2C+Timothy+P%3BDinovi%2C+Michael+J%3BPerfetti%2C+Gracia+A&rft.aulast=Morehouse&rft.aufirst=Kim&rft.date=2008-03-01&rft.volume=25&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030701552949 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Furans; body weight; Food additives; Diets; Risk assessment; Mass spectrometry; coffee; Carcinogens; Gas chromatography; subpopulations DO - http://dx.doi.org/10.1080/02652030701552949 ER - TY - JOUR T1 - Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models AN - 20869816; 8244799 AB - There is a growing demand for a cost-effective, efficient, and high-throughput method for measuring cytokines. Currently, many studies are using flow cytometric bead-based multiplex assays in the measurement of cytokines. However, limited data are available regarding the performance of these cytometric bead assays versus enzyme-linked immunosorbent assay (ELISA) or correlation with mRNA expression using real time reverse transcriptase-polymerase chain reaction (RT-PCR). In one of our studies, cytometric bead array (CBA) was used to measure inflammatory cytokine protein levels in bronchoalveolar lavage (BAL) samples from mice exposed to welding fume, an inflammatory particulate. The results were then compared to whole lung mRNA levels of the same cytokines measured by real time RT-PCR in the same mouse model. It was found that the trends in cytokine profiles measured via CBA agreed with the whole lung mRNA results. In a separate experiment, we used a rat zymosan infectivity model to induce a pulmonary immunomodulatory response and determined cytokine concentrations in recovered BAL fluid by ELISA and two different types of cytometric bead-based assays, CBA and FlowCytomix (FC). The sample-to-sample correlation was good between ELISA and CBA with correlation coefficient R values of 0.76, 0.66, and 0.92 for rat IFN- gamma , TNF- alpha , and IL-6, respectively. ELISA only correlated significantly with the FC assay for TNF- alpha with R=0.43. Patterns of cytokine response in our rat model also differed among the assays but overall, the ELISA and CBA yielded similar results. For a method-to-method comparison, we assayed supplied cytokine standards from ELISA kits using both ELISA and CBA to determine the R values and found it to be greater than 0.90 for all the cytokines tested. It was found that the ELISA was more sensitive in the low range of the standard curve while the bead assays were capable of detecting higher protein concentrations, which would allow for direct measurement of concentrated samples. There was a lack of agreement between the absolute protein values for the ELISA and flow cytometric bead-based assays; in most cases, the latter method tended to give higher protein concentrations than ELISA. In conclusion, direct comparisons between absolute protein values did not agree among the assays tested in this study, but patterns of cytokine response generally agreed between ELISA and CBA. In the case of the mouse CBA, a companion measurement is recommended if samples with low concentrations of an analyte are reported and extrapolated below sensitivity or zero. JF - Journal of Immunological Methods AU - Young, SH AU - Antonini, J M AU - Roberts, J R AU - Erdely, AD AU - Zeidler-Erdely, P C AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States, syoung@cdc.gov Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 SP - 59 EP - 68 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 331 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Interleukin 6 KW - gamma -Interferon KW - Fc KW - Enzyme-linked immunosorbent assay KW - Fumes KW - Data processing KW - Animal models KW - Alveoli KW - Inflammation KW - Gene expression KW - Flow cytometry KW - Infectivity KW - Bronchus KW - Lung KW - Polymerase chain reaction KW - Cytokines KW - Welding KW - Tumor necrosis factor- alpha KW - F 06900:Methods KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20869816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Performance+evaluation+of+cytometric+bead+assays+for+the+measurement+of+lung+cytokines+in+two+rodent+models&rft.au=Young%2C+SH%3BAntonini%2C+J+M%3BRoberts%2C+J+R%3BErdely%2C+AD%3BZeidler-Erdely%2C+P+C&rft.aulast=Young&rft.aufirst=SH&rft.date=2008-02-29&rft.volume=331&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Fc; gamma -Interferon; Enzyme-linked immunosorbent assay; Data processing; Fumes; Animal models; Alveoli; Inflammation; Flow cytometry; Gene expression; Infectivity; Bronchus; Lung; Welding; Cytokines; Polymerase chain reaction; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.jim.2007.11.004 ER - TY - CPAPER T1 - A Microcentrifuge-Tube Sampler: Development and Application T2 - 7th International Symposium on Advanced Environmental Monitoring (ISAEM 2008) AN - 40787870; 4789126 JF - 7th International Symposium on Advanced Environmental Monitoring (ISAEM 2008) AU - Chen, Bean T Y1 - 2008/02/25/ PY - 2008 DA - 2008 Feb 25 KW - Samplers KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40787870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Symposium+on+Advanced+Environmental+Monitoring+%28ISAEM+2008%29&rft.atitle=A+Microcentrifuge-Tube+Sampler%3A+Development+and+Application&rft.au=Chen%2C+Bean+T&rft.aulast=Chen&rft.aufirst=Bean&rft.date=2008-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Symposium+on+Advanced+Environmental+Monitoring+%28ISAEM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://ademrc.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Universal Virus Detection T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40839208; 4809165 DE: JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Uhlenhaut, C AU - Nanda, S AU - Tang, S AU - SierraHonigmann, A AU - Krause, P R Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Universal+Virus+Detection&rft.au=Uhlenhaut%2C+C%3BNanda%2C+S%3BTang%2C+S%3BSierraHonigmann%2C+A%3BKrause%2C+P+R&rft.aulast=Uhlenhaut&rft.aufirst=C&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Species Neutral Protein G ELISA for Evaluation of Plague Vaccine Efficacy T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40838499; 4809227 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Meysick, K AU - Falconio, J AU - Schlomer, J Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Vaccines KW - Protein G KW - ELISA KW - Plague KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Development+of+a+Species+Neutral+Protein+G+ELISA+for+Evaluation+of+Plague+Vaccine+Efficacy&rft.au=Meysick%2C+K%3BFalconio%2C+J%3BSchlomer%2C+J&rft.aulast=Meysick&rft.aufirst=K&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Francisella tularensis from Foods using the Pathatrix Immunomagnetic Capture System T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40836094; 4809149 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Hanes, D E AU - EwingPeeples, L AU - Kothary, M H AU - Tall, B D Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Food KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Isolation+of+Francisella+tularensis+from+Foods+using+the+Pathatrix+Immunomagnetic+Capture+System&rft.au=Hanes%2C+D+E%3BEwingPeeples%2C+L%3BKothary%2C+M+H%3BTall%2C+B+D&rft.aulast=Hanes&rft.aufirst=D&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing the Population Diversity of Escherichia coli T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40829469; 4809118 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Cebula, Thomas A Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Species diversity KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40829469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Probing+the+Population+Diversity+of+Escherichia+coli&rft.au=Cebula%2C+Thomas+A&rft.aulast=Cebula&rft.aufirst=Thomas&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Smallpox Vaccines and IgG Preparations by Bioimaging of TK+ Vaccinia Luciferase Virus Dissemination in Live Mice T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40828406; 4809068 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Zaitseva, M AU - Manischewitz, J AU - King, L AU - Nielsen, H AU - Golding, H Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Vaccines KW - Mice KW - Smallpox KW - Immunoglobulin G KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Evaluation+of+Smallpox+Vaccines+and+IgG+Preparations+by+Bioimaging+of+TK%2B+Vaccinia+Luciferase+Virus+Dissemination+in+Live+Mice&rft.au=Zaitseva%2C+M%3BManischewitz%2C+J%3BKing%2C+L%3BNielsen%2C+H%3BGolding%2C+H&rft.aulast=Zaitseva&rft.aufirst=M&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Food Safety: Bacterial Pathogens and Toxins T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40825058; 4809108 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Acheson, David Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Pathogens KW - Toxins KW - Reviews KW - Food KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Overview+of+Food+Safety%3A+Bacterial+Pathogens+and+Toxins&rft.au=Acheson%2C+David&rft.aulast=Acheson&rft.aufirst=David&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. AN - 70379604; 18291036 AB - Levels of pesticides and other compounds in carpet dust can be useful indicators of exposure in epidemiologic studies, particularly for young children who are in frequent contact with carpets. The high-volume surface sampler (HVS3) is often used to collect dust samples in the room in which the child had spent the most time. This method can be expensive and cumbersome, and it has been suggested that an easier method would be to remove dust that had already been collected with the household vacuum cleaner. However, the household vacuum integrates exposures over multiple rooms, some of which are not relevant to the child's exposure, and differences in vacuuming equipment and practices could affect the chemical concentration data. Here, we compare levels of pesticides and other compounds in dust from household vacuums to that collected using the HVS3. Both methods were used in 45 homes in California. HVS3 samples were collected in one room, while the household vacuum had typically been used throughout the home. The samples were analyzed for 64 organic compounds, including pesticides, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls (PCBs), using GC/MS in multiple ion monitoring mode; and for nine metals using conventional microwave-assisted acid digestion combined with ICP/MS. The methods agreed in detecting the presence of the compounds 77% to 100% of the time (median 95%). For compounds with less than 100% agreement, neither method was consistently more sensitive than the other. Median concentrations were similar for most analytes, and Spearman correlation coefficients were 0.60 or higher except for allethrin (0.15) and malathion (0.24), which were detected infrequently, and benzo(k)fluoranthene (0.55), benzo(a)pyrene (0.55), PCB 105 (0.54), PCB 118 (0.54), and PCB 138 (0.58). Assuming that the HVS3 method is the "gold standard," the extent to which the household vacuum cleaner method yields relative risk estimates closer to unity by increasing random measurement error varies by compound and depends on the method used to calculate relative risk. The household vacuum cleaner method appears to be a reasonable alternative to the HVS3 for detecting, ranking, and quantifying the concentrations of pesticides and other compounds in carpet dust. JF - Environmental health : a global access science source AU - Colt, Joanne S AU - Gunier, Robert B AU - Metayer, Catherine AU - Nishioka, Marcia G AU - Bell, Erin M AU - Reynolds, Peggy AU - Buffler, Patricia A AU - Ward, Mary H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd. MSC 7240, Bethesda, MD, 20892-7240, USA. coltj@mail.nih.gov Y1 - 2008/02/21/ PY - 2008 DA - 2008 Feb 21 SP - 6 VL - 7 KW - Dust KW - 0 KW - Pesticide Residues KW - Index Medicus KW - Housekeeping KW - California KW - Epidemiologic Studies KW - Humans KW - Environmental Exposure -- analysis KW - Pesticide Residues -- isolation & purification KW - Floors and Floorcoverings KW - Dust -- analysis KW - Specimen Handling -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70379604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Household+vacuum+cleaners+vs.+the+high-volume+surface+sampler+for+collection+of+carpet+dust+samples+in+epidemiologic+studies+of+children.&rft.au=Colt%2C+Joanne+S%3BGunier%2C+Robert+B%3BMetayer%2C+Catherine%3BNishioka%2C+Marcia+G%3BBell%2C+Erin+M%3BReynolds%2C+Peggy%3BBuffler%2C+Patricia+A%3BWard%2C+Mary+H&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2008-02-21&rft.volume=7&rft.issue=&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-7-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Air Waste Manag Assoc. 2001 Mar;51(3):339-51 [11266098] Breast Cancer Res Treat. 2002 Jun;74(3):235-54 [12206514] Int J Epidemiol. 1989 Sep;18(3):705-12 [2807678] Sci Total Environ. 1990 Jan;90:13-29 [2305239] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):143-55 [1844216] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):331-49 [16736054] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 1999 Sep;107(9):721-6 [10464072] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Am J Epidemiol. 2006 Jun 15;163(12):1091-100 [16597704] Environ Res. 1995 Feb;68(2):114-23 [7601072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-069X-7-6 ER - TY - JOUR T1 - Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. AN - 70326535; 18297132 AB - Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure. We performed gene expression analysis using HG-U133A Affymetrix chips on 135 fresh frozen tissue samples of adenocarcinoma and paired noninvolved lung tissue from current, former and never smokers, with biochemically validated smoking information. ANOVA analysis adjusted for potential confounders, multiple testing procedure, Gene Set Enrichment Analysis, and GO-functional classification were conducted for gene selection. Results were confirmed in independent adenocarcinoma and non-tumor tissues from two studies. We identified a gene expression signature characteristic of smoking that includes cell cycle genes, particularly those involved in the mitotic spindle formation (e.g., NEK2, TTK, PRC1). Expression of these genes strongly differentiated both smokers from non-smokers in lung tumors and early stage tumor tissue from non-tumor tissue (p1.5, for each comparison), consistent with an important role for this pathway in lung carcinogenesis induced by smoking. These changes persisted many years after smoking cessation. NEK2 (p<0.001) and TTK (p = 0.002) expression in the noninvolved lung tissue was also associated with a 3-fold increased risk of mortality from lung adenocarcinoma in smokers. Our work provides insight into the smoking-related mechanisms of lung neoplasia, and shows that the very mitotic genes known to be involved in cancer development are induced by smoking and affect survival. These genes are candidate targets for chemoprevention and treatment of lung cancer in smokers. JF - PloS one AU - Landi, Maria Teresa AU - Dracheva, Tatiana AU - Rotunno, Melissa AU - Figueroa, Jonine D AU - Liu, Huaitian AU - Dasgupta, Abhijit AU - Mann, Felecia E AU - Fukuoka, Junya AU - Hames, Megan AU - Bergen, Andrew W AU - Murphy, Sharon E AU - Yang, Ping AU - Pesatori, Angela C AU - Consonni, Dario AU - Bertazzi, Pier Alberto AU - Wacholder, Sholom AU - Shih, Joanna H AU - Caporaso, Neil E AU - Jen, Jin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 SP - 1 VL - 3 IS - 2 KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Biopsy KW - Cell Transformation, Neoplastic KW - Gene Expression Profiling KW - Lung Neoplasms -- etiology KW - Genes, cdc KW - Adenocarcinoma -- etiology KW - Smoking -- adverse effects KW - Smoking -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70326535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Gene+expression+signature+of+cigarette+smoking+and+its+role+in+lung+adenocarcinoma+development+and+survival.&rft.au=Landi%2C+Maria+Teresa%3BDracheva%2C+Tatiana%3BRotunno%2C+Melissa%3BFigueroa%2C+Jonine+D%3BLiu%2C+Huaitian%3BDasgupta%2C+Abhijit%3BMann%2C+Felecia+E%3BFukuoka%2C+Junya%3BHames%2C+Megan%3BBergen%2C+Andrew+W%3BMurphy%2C+Sharon+E%3BYang%2C+Ping%3BPesatori%2C+Angela+C%3BConsonni%2C+Dario%3BBertazzi%2C+Pier+Alberto%3BWacholder%2C+Sholom%3BShih%2C+Joanna+H%3BCaporaso%2C+Neil+E%3BJen%2C+Jin&rft.aulast=Landi&rft.aufirst=Maria&rft.date=2008-02-20&rft.volume=3&rft.issue=2&rft.spage=e1651&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0001651 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Jan;82(1):65-73 [10638968] Nat Med. 2007 Jul;13(7):820-7 [17589519] Nat Genet. 2000 May;25(1):25-9 [10802651] Cancer Res. 2000 Nov 1;60(21):6116-33 [11085536] Cancer Res. 2002 Jun 1;62(11):3244-50 [12036940] J Cell Biol. 2002 Aug 19;158(4):617-23 [12177045] Nat Cell Biol. 2002 Dec;4(12):976-80 [12447387] Genome Biol. 2003;4(4):R28 [12702209] Am J Respir Cell Mol Biol. 2003 Aug;29(2):157-62 [12600827] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):445-53 [15006922] J Biol Chem. 2004 May 7;279(19):20049-57 [14978040] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10143-8 [15210990] J Cell Biol. 2004 Sep 27;166(7):949-55 [15452138] Chest. 2007 Jul;132(1):185-92 [17573517] Mol Biol Cell. 2007 Oct;18(10):4024-36 [17671160] Proc Am Thorac Soc. 2007 Jan;4(1):127-32 [17202302] Cancer Res. 1999 Feb 1;59(3):590-6 [9973205] Nat Rev Cancer. 2004 Dec;4(12):927-36 [15573114] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] Am J Respir Crit Care Med. 2005 Dec 1;172(11):1383-92 [16166618] J Mol Med (Berl). 2006 Apr;84(4):318-28 [16520944] Bioinformatics. 2006 Apr 15;22(8):943-9 [16473874] J Pathol. 2006 Oct;210(2):192-204 [16915569] J Mol Med (Berl). 2007 Jan;85(1):39-53 [17115125] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] Carcinogenesis. 2007 May;28(5):899-912 [17259655] Cancer Res. 2000 Apr 1;60(7):1949-60 [10766185] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0001651 ER - TY - JOUR T1 - The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex. AN - 70303744; 18201836 AB - The anesthetic gas nitrous oxide (N2O) and the volatile anesthetic isoflurane (ISO) are commonly used in surgical procedures for human infants and in veterinary and laboratory animal practice to produce loss of consciousness and analgesia. Recent reports indicate that exposure of the developing brain to general anesthetics that block N-methyl-D-aspartate (NMDA) glutamate receptors or potentiate GABA(A) receptors can trigger widespread apoptotic neurodegeneration. In the present study, the question arises whether a relatively low dose of ISO alone or its combination with N2O entails significant risk of inducing enhanced apoptosis. In addition, the role of L-carnitine to attenuate these effects was also examined. Postnatal day 7 (PND-7) rat pups were exposed to N2O (75%) or a low dose of ISO (0.55%) alone, or N2O plus ISO for 2, 4, 6 or 8 h with or without L-carnitine. The neurotoxic effects were evaluated 6 h after completion of anesthetic administration. No significant neurotoxic effects were observed for the animals exposed to N2O or ISO alone. However, enhanced apoptotic cell death was apparent when N2O was combined with ISO at exposure durations of 6 h or more. Co-administration of L-carnitine (300 or 500 mg/kg, i.p.) effectively protected neurons from the anesthetic-induced damage. These data indicate that 6 h or more of inhaled anesthetic exposure consisting of a combination of N2O and ISO results in enhanced neuronal apoptosis, and L-carnitine effectively blocks the neuronal apoptosis caused by inhalation anesthetics in the developing rat brain. JF - Neuroscience AU - Zou, X AU - Sadovova, N AU - Patterson, T A AU - Divine, R L AU - Hotchkiss, C E AU - Ali, S F AU - Hanig, J P AU - Paule, M G AU - Slikker, W AU - Wang, C AD - Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2008/02/19/ PY - 2008 DA - 2008 Feb 19 SP - 1053 EP - 1065 VL - 151 IS - 4 SN - 0306-4522, 0306-4522 KW - Anesthetics, Inhalation KW - 0 KW - Bcl2l1 protein, rat KW - Drug Combinations KW - Fluoresceins KW - Neural Cell Adhesion Molecule L1 KW - Organic Chemicals KW - Sialic Acids KW - bcl-2-Associated X Protein KW - bcl-X Protein KW - fluoro jade KW - polysialyl neural cell adhesion molecule KW - Vitamin B Complex KW - 12001-76-2 KW - Isoflurane KW - CYS9AKD70P KW - Caspase 3 KW - EC 3.4.22.- KW - Nitrous Oxide KW - K50XQU1029 KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Animals KW - Nitrous Oxide -- toxicity KW - Dose-Response Relationship, Drug KW - Isoflurane -- toxicity KW - Neural Cell Adhesion Molecule L1 -- metabolism KW - Sialic Acids -- metabolism KW - bcl-X Protein -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Rats KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Time Factors KW - Caspase 3 -- metabolism KW - Vitamin B Complex -- pharmacology KW - Frontal Lobe -- cytology KW - Anesthetics, Inhalation -- toxicity KW - Neurons -- drug effects KW - Carnitine -- pharmacology KW - Neurons -- cytology KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70303744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=The+effects+of+L-carnitine+on+the+combination+of%2C+inhalation+anesthetic-induced+developmental%2C+neuronal+apoptosis+in+the+rat+frontal+cortex.&rft.au=Zou%2C+X%3BSadovova%2C+N%3BPatterson%2C+T+A%3BDivine%2C+R+L%3BHotchkiss%2C+C+E%3BAli%2C+S+F%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Zou&rft.aufirst=X&rft.date=2008-02-19&rft.volume=151&rft.issue=4&rft.spage=1053&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2007.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2007.12.013 ER - TY - CPAPER T1 - Volume Error Analysis for Lung Nodules Attached to Bronchial Vessels in an Anthropomorphic Thoracic Phantom T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40723949; 4761563 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Kinnard, Lisa M AU - Gavrielides, Marios A AU - Peregoy, Jennifer AU - Pritchard, William F AU - Petrick, Nicholas A AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Lung nodules KW - Nodules KW - Thorax KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Volume+Error+Analysis+for+Lung+Nodules+Attached+to+Bronchial+Vessels+in+an+Anthropomorphic+Thoracic+Phantom&rft.au=Kinnard%2C+Lisa+M%3BGavrielides%2C+Marios+A%3BPeregoy%2C+Jennifer%3BPritchard%2C+William+F%3BPetrick%2C+Nicholas+A%3BMyers%2C+Kyle+J&rft.aulast=Kinnard&rft.aufirst=Lisa&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Display Methods for Adjustable Grayscale and Luminance Depth T2 - Conference on PACS and Imaging Informatics (MI07) AN - 40720165; 4761891 DE: JF - Conference on PACS and Imaging Informatics (MI07) AU - Xu, An AU - Saha, Anindita AU - Guarnieri, Gabriele AU - Ramponi, Giovanni AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+PACS+and+Imaging+Informatics+%28MI07%29&rft.atitle=Display+Methods+for+Adjustable+Grayscale+and+Luminance+Depth&rft.au=Xu%2C+An%3BSaha%2C+Anindita%3BGuarnieri%2C+Gabriele%3BRamponi%2C+Giovanni%3BBadano%2C+Aldo&rft.aulast=Xu&rft.aufirst=An&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+PACS+and+Imaging+Informatics+%28MI07%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783661&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Singular Vectors of an Imaging Sytem Matrix as Efficient Channels for the Ideal Observer in Detection Tasks Involving Non-Gaussian Distributed Lumpy Images T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40719657; 4761742 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Witten, Joel M AU - Park, Subok AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Channels KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Singular+Vectors+of+an+Imaging+Sytem+Matrix+as+Efficient+Channels+for+the+Ideal+Observer+in+Detection+Tasks+Involving+Non-Gaussian+Distributed+Lumpy+Images&rft.au=Witten%2C+Joel+M%3BPark%2C+Subok%3BMyers%2C+Kyle+J&rft.aulast=Witten&rft.aufirst=Joel&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hybrid Linear Classifier for Jointly Normal Data: Theory T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40719305; 4761486 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Chen, Weijie AU - Metz, Charles E AU - Giger, Maryellen L Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Hybrid+Linear+Classifier+for+Jointly+Normal+Data%3A+Theory&rft.au=Chen%2C+Weijie%3BMetz%2C+Charles+E%3BGiger%2C+Maryellen+L&rft.aulast=Chen&rft.aufirst=Weijie&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Markov-Chain Monte Carlo for the Performance of a Channelized-Ideal Observer in Detection Tasks with Non-Gaussian Lumpy Backgrounds T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40719190; 4761741 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Park, Subok AU - Clarkson, Eric W Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Statistical analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Markov-Chain+Monte+Carlo+for+the+Performance+of+a+Channelized-Ideal+Observer+in+Detection+Tasks+with+Non-Gaussian+Lumpy+Backgrounds&rft.au=Park%2C+Subok%3BClarkson%2C+Eric+W&rft.aulast=Park&rft.aufirst=Subok&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparisons of Two Agreement Measures T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40715810; 4761702 DE: JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Liu, Weimin AU - Gallas, Brandon D Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparisons+of+Two+Agreement+Measures&rft.au=Liu%2C+Weimin%3BGallas%2C+Brandon+D&rft.aulast=Liu&rft.aufirst=Weimin&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparing Signal-Based and Case-Based Methodologies for CAD Assessment in a Detection Task T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40714159; 4761697 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Paquerault, Sophie AU - Samuelson, Frank W AU - Petrick, Nicholas A AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Technology assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparing+Signal-Based+and+Case-Based+Methodologies+for+CAD+Assessment+in+a+Detection+Task&rft.au=Paquerault%2C+Sophie%3BSamuelson%2C+Frank+W%3BPetrick%2C+Nicholas+A%3BMyers%2C+Kyle+J&rft.aulast=Paquerault&rft.aufirst=Sophie&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Efficient Depth- and Energy-Dependent Monte Carlo Model for Columnar CsI Detector T2 - Conference on Physics of Medical Imaging (MI01) AN - 40714031; 4761130 JF - Conference on Physics of Medical Imaging (MI01) AU - Kyprianou, Iacovos S AU - Brackman, Gabriel AU - Badal, Andreu AU - Myers, Kyle J AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Models KW - Statistical analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physics+of+Medical+Imaging+%28MI01%29&rft.atitle=An+Efficient+Depth-+and+Energy-Dependent+Monte+Carlo+Model+for+Columnar+CsI+Detector&rft.au=Kyprianou%2C+Iacovos+S%3BBrackman%2C+Gabriel%3BBadal%2C+Andreu%3BMyers%2C+Kyle+J%3BBadano%2C+Aldo&rft.aulast=Kyprianou&rft.aufirst=Iacovos&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physics+of+Medical+Imaging+%28MI01%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783650&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Model Observer for the Assessment of Display Temporal Characteristics T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40713856; 4761738 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Liang, Hongye AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40713856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=A+Model+Observer+for+the+Assessment+of+Display+Temporal+Characteristics&rft.au=Liang%2C+Hongye%3BBadano%2C+Aldo&rft.aulast=Liang&rft.aufirst=Hongye&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. AN - 70300970; 18191113 AB - Alterations in inflammatory process, neuronal death, and glia response have been observed under manipulation of interleukin-1 (IL-1) and subsequent signaling through the type 1 IL-1 receptor (IL-1R1). To investigate the influence of IL-1R1 activation in the pathophysiology of a chemical-induced injury to the murine hippocampus, we examined the level and pattern of neuronal death and neuroinflammation in male weanling mice exposed to trimethyltin hydroxide (2.0 mg TMT/kg, i.p.). Dentate granule cell death occurred at 6 h post-TMT as detected by active caspase 3 immunostaining and presence of lectin positive microglia. The severity of neuronal death and microglia response increased by 12-24 h with elevations in mRNA levels for TNFalpha and IL-1alpha. In IL-1R1 null (IL-1R1-/-) mice, the pattern and severity of neuronal death at 24 or 72 h post-TMT was similar as compared to wildtype (WT) mice. In both groups, mRNA levels for TNFalpha and MIP-1alpha were elevated, no significant change was seen in either IL-1alpha or IL-1beta, and the early activation of microglia, including their ability to progress to a phagocytic phenotype, was maintained. Compared to WT mice, IL-1R1-/- mice displayed a limited glial fibrillary acidic protein (GFAP) astrocytic response, as well as a preferential induction in mRNA levels of Fas signaling components. Cumulatively, these results indicate that IL-1R1 activation is not necessary for TMT-induced death of dentate granule neurons or local activation of microglia; however, IL-1R1 signaling is involved in mediating the structural response of astrocytes to injury and may regulate apoptotic mechanisms via Fas signaling components. JF - Brain research AU - Harry, G Jean AU - Funk, Jason A AU - Lefebvre d'Hellencourt, Christian AU - McPherson, Christopher A AU - Aoyama, Mineyoshi AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 8 EP - 20 VL - 1194 SN - 0006-8993, 0006-8993 KW - Apoptosis Regulatory Proteins KW - 0 KW - Glial Fibrillary Acidic Protein KW - Interleukin-1alpha KW - Lectins KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Receptors, Interleukin-1 KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - trimethyltin hydroxide KW - 56-24-6 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Myeloid Differentiation Factor 88 -- metabolism KW - Animals KW - Cell Death -- physiology KW - Apoptosis Regulatory Proteins -- genetics KW - Trimethyltin Compounds -- pharmacology KW - Random Allocation KW - Interleukin-1alpha -- metabolism KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Tumor Necrosis Factor-alpha -- genetics KW - Mice, Knockout KW - Gene Expression Regulation -- genetics KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Tumor Necrosis Factor-alpha -- metabolism KW - Time Factors KW - Male KW - Lectins -- metabolism KW - Caspase 3 -- metabolism KW - Interleukin-1alpha -- genetics KW - Receptors, Interleukin-1 -- deficiency KW - Microglia -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Dentate Gyrus -- cytology KW - Receptors, Interleukin-1 -- physiology KW - Microglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+type+1+interleukin+1+receptor+is+not+required+for+the+death+of+murine+hippocampal+dentate+granule+cells+and+microglia+activation.&rft.au=Harry%2C+G+Jean%3BFunk%2C+Jason+A%3BLefebvre+d%27Hellencourt%2C+Christian%3BMcPherson%2C+Christopher+A%3BAoyama%2C+Mineyoshi&rft.aulast=Harry&rft.aufirst=G&rft.date=2008-02-15&rft.volume=1194&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2007.11.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-30 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Growth Differ. 1999 Dec;10(12):797-804 [10616904] Brain Res. 1995 Feb 13;671(2):261-6 [7743213] Neuroimmunomodulation. 2000;7(3):153-9 [10754403] Cytokine. 2000 May;12(5):423-31 [10857755] J Neurosci. 2000 Sep 15;20(18):6811-9 [10995825] Trends Neurosci. 2000 Dec;23(12):618-25 [11137152] Exp Neurol. 2001 Mar;168(1):23-31 [11170718] J Neurosci. 2001 Aug 1;21(15):5528-34 [11466424] Brain Res. 2001 Sep 7;912(2):116-27 [11532427] Nat Rev Neurosci. 2001 Oct;2(10):734-44 [11584311] J Neurosci Res. 2001 Nov 1;66(3):464-74 [11746364] J Neurosci. 2002 Jan 1;22(1):38-43 [11756486] J Neurosci. 1995 May;15(5 Pt 1):3468-74 [7538561] J Biol Chem. 1995 Jun 9;270(23):13757-65 [7775431] Am J Pathol. 1995 Nov;147(5):1477-86 [7485410] J Comp Neurol. 1995 Oct 30;361(4):681-98 [8576422] Blood. 1996 Mar 15;87(6):2095-147 [8630372] Neuroimmunomodulation. 1995 May-Jun;2(3):121-33 [8646560] FEBS Lett. 1996 Oct 7;394(3):273-8 [8830657] J Cereb Blood Flow Metab. 1996 Nov;16(6):1137-42 [8898685] Neuroreport. 1996 Sep 2;7(13):2181-5 [8930985] Biochem Biophys Res Commun. 1997 May 8;234(1):211-5 [9168991] Immunity. 1997 Dec;7(6):837-47 [9430229] J Neurosci Res. 1998 Apr 1;52(1):7-16 [9556025] J Leukoc Biol. 1998 Jun;63(6):650-7 [9620655] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] J Cereb Blood Flow Metab. 1999 Jan;19(1):87-98 [9886359] J Neurochem. 1999 Apr;72(4):1353-61 [10098836] Neurosci Res. 1999 Apr;33(4):251-60 [10401977] Neuroscience. 1999;93(3):915-30 [10473257] Exp Neurol. 2005 Jan;191(1):145-53 [15589521] J Cereb Blood Flow Metab. 2005 Jan;25(1):17-29 [15678109] Neurotox Res. 2005;7(3):183-92 [15897153] Nat Rev Immunol. 2005 Aug;5(8):629-40 [16034365] Glia. 2006 Apr 1;53(5):551-6 [16374779] Am J Clin Nutr. 2006 Feb;83(2):470S-474S [16470015] J Neuroimmunol. 2006 Jun;175(1-2):97-106 [16626814] Int J Mol Med. 2006 Jul;18(1):33-9 [16786153] J Neurochem. 2006 Jul;98(1):258-66 [16805812] Stroke. 2005 Oct;36(10):2226-31 [16179572] Neuroscience. 2006;137(1):301-8 [16289587] Methods. 2001 Dec;25(4):402-8 [11846609] Br J Pharmacol. 2002 May;136(2):312-20 [12010781] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] J Neurosci. 2002 Jul 15;22(14):6071-82 [12122068] J Neuroimmunol. 2002 Nov;132(1-2):60-5 [12417434] Neuroimmunomodulation. 2002-2003;10(4):199-207 [12584407] Brain Behav Immun. 2003 Jun;17(3):152-7 [12706413] Neurotoxicology. 2003 Jun;24(3):343-56 [12782100] J Neuroimmunol. 2003 Aug;141(1-2):141-9 [12965265] J Neurosci. 2003 Sep 24;23(25):8692-700 [14507968] Adv Exp Med Biol. 2004;548:57-68 [15250585] J Neurosci. 1988 Jul;8(7):2485-90 [2470873] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7611-5 [2529544] J Neurochem. 1992 Feb;58(2):454-60 [1729393] J Neurosci. 1992 Mar;12(3):1101-14 [1532025] J Cell Biol. 1992 Apr;117(2):395-400 [1560032] Brain Res. 1993 Nov 19;628(1-2):227-34 [8313151] Neuroscience. 1994 Feb;58(3):563-72 [8170537] Immunol Today. 1994 Dec;15(12):562-6 [7848516] Neurosci Lett. 1994 Oct 24;180(2):147-50 [7700568] Science. 1995 Apr 21;268(5209):411-5 [7536343] J Neuroimmunol. 1999 Dec;100(1-2):203-15 [10695731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2007.11.076 ER - TY - CPAPER T1 - Characterization of Proteins Associated with Cardiac Myofibrils using a Proteomic Approach T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726987; 4766127 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Edmondson, Ricky D AU - Jones, Richard C AU - Gomes, Aldrin V Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Proteomics KW - Myofibrils KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Characterization+of+Proteins+Associated+with+Cardiac+Myofibrils+using+a+Proteomic+Approach&rft.au=Edmondson%2C+Ricky+D%3BJones%2C+Richard+C%3BGomes%2C+Aldrin+V&rft.aulast=Edmondson&rft.aufirst=Ricky&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Associations between Outpatient and Inpatient Service Use among Persons with HIV Infection: A Positive or Negative Relationship? AN - 839570535; 201101284 AB - Objective. To examine the prospective association between frequency of outpatient visits and subsequent inpatient admissions. Data Sources. Medical record data on 13,942 patients with HIV infection seen in 10 HIV specialty care sites across the United States. Study Design. This observational study followed a cohort of HIV-infected patients who were in care in the first half of 2001. Numbers of inpatient admissions and outpatient visits were calculated for each patient for each 3-month period, from 2001 through 2004. Analysis. Negative binomial and logistic regression analyses using random-effects models examined the effects of inpatient admissions and outpatient visits in the previous period on inpatient and outpatient service utilization, controlling for background characteristics and HIV disease stage. Results. For 3-month periods, between 5 and 9 percent of patients had an inpatient admission. The linear association between number of outpatient visits and any inpatient admission in the subsequent period was positive (adjusted odds ratio=1.05; 95 percent confidence interval [CI]=1.04, 1.06). However, patients with zero prior outpatient visits had significantly greater admission rates than those with one prior visit. Hospitalization rates were also higher among those with a prior hospitalization and those with more advanced HIV disease. Conclusions. These results suggest a J-shaped relationship between outpatient use and inpatient use among persons with HIV disease. Those in worse health have greater utilization of both inpatient and outpatient care. However, having no outpatient visits may also increase the likelihood of subsequent hospitalization. Although outpatient care cannot be justified as a cost-saving mechanism, maintaining regular clinical monitoring of patients is important. Adapted from the source document. JF - Health Services Research AU - Fleishman, John A AU - Moore, Richard D AU - Conviser, Richard AU - Lawrence, Perrin B AU - Korthuis, P Todd AU - Gebo, Kelly A AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 76 EP - 95 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 1p1 SN - 0017-9124, 0017-9124 KW - HIV infection KW - inpatient service use KW - outpatient service use KW - Hospitalization KW - Background characteristics KW - Infection KW - HIV KW - Confidence intervals KW - Outpatient treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Associations+between+Outpatient+and+Inpatient+Service+Use+among+Persons+with+HIV+Infection%3A+A+Positive+or+Negative+Relationship%3F&rft.au=Fleishman%2C+John+A%3BMoore%2C+Richard+D%3BConviser%2C+Richard%3BLawrence%2C+Perrin+B%3BKorthuis%2C+P+Todd%3BGebo%2C+Kelly+A&rft.aulast=Fleishman&rft.aufirst=John&rft.date=2008-02-01&rft.volume=43&rft.issue=1p1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2007.00750.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitalization; HIV; Outpatient treatment; Infection; Confidence intervals; Background characteristics DO - http://dx.doi.org/10.1111/j.1475-6773.2007.00750.x ER - TY - JOUR T1 - Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats. AN - 70719926; 18474946 AB - Inhalation of butter flavoring vapors by food manufacturing workers causes an emerging lung disease clinically resembling bronchiolitis obliterans. Diacetyl, an alpha-diketone, is a major component of these vapors. In rats, we investigated the toxicity of inhaled diacetyl at concentrations of up to 365 ppm (time weighted average), either as six-hour continuous exposures or as four brief, intense exposures over six hours. A separate group inhaled a single pulse of ~1800 ppm diacetyl (92.9 ppm six-hour average). Rats were necropsied 18 to 20 hours after exposure. Diacetyl inhalation caused epithelial necrosis and suppurative to fibrinosuppurative inflammation in the nose, larynx, trachea, and bronchi. Bronchi were affected at diacetyl concentrations of 294.6 ppm or greater; the trachea and larynx were affected at diacetyl concentrations of 224 ppm or greater. Both pulsed and continuous exposure patterns caused epithelial injury. The nose had the greatest sensitivity to diacetyl. Ultrastructural changes in the tracheal epithelium included whorling and dilation of the rough endoplasmic reticulum, chromatin clumping beneath the nuclear membrane, vacuolation, increased inter-cellular space and foci of denuded basement membrane. Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard. JF - Toxicologic pathology AU - Hubbs, Ann F AU - Goldsmith, William T AU - Kashon, Michael L AU - Frazer, David AU - Mercer, Robert R AU - Battelli, Lori A AU - Kullman, Gregory J AU - Schwegler-Berry, Diane AU - Friend, Sherri AU - Castranova, Vincent AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. ahubbs@cdc.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 330 EP - 344 VL - 36 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Animals KW - Basement Membrane -- ultrastructure KW - Neutrophils -- pathology KW - Dose-Response Relationship, Drug KW - Basement Membrane -- drug effects KW - Bronchi -- drug effects KW - Trachea -- ultrastructure KW - Rats KW - Neutrophils -- drug effects KW - Microscopy, Electron, Transmission KW - Rats, Sprague-Dawley KW - Necrosis KW - Bronchi -- ultrastructure KW - Atmosphere Exposure Chambers KW - Trachea -- drug effects KW - Administration, Inhalation KW - Male KW - Microscopy, Electron, Scanning KW - Diacetyl -- toxicity KW - Respiratory Tract Diseases -- chemically induced KW - Respiratory Mucosa -- drug effects KW - Respiratory Tract Diseases -- pathology KW - Air Pollutants, Occupational -- toxicity KW - Respiratory Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Respiratory+toxicologic+pathology+of+inhaled+diacetyl+in+sprague-dawley+rats.&rft.au=Hubbs%2C+Ann+F%3BGoldsmith%2C+William+T%3BKashon%2C+Michael+L%3BFrazer%2C+David%3BMercer%2C+Robert+R%3BBattelli%2C+Lori+A%3BKullman%2C+Gregory+J%3BSchwegler-Berry%2C+Diane%3BFriend%2C+Sherri%3BCastranova%2C+Vincent&rft.aulast=Hubbs&rft.aufirst=Ann&rft.date=2008-02-01&rft.volume=36&rft.issue=2&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623307312694 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623307312694 ER - TY - JOUR T1 - Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury. AN - 70719837; 18349426 AB - The present study was undertaken to characterize myocardial lesions in the rat induced by low doses of isoproterenol (Iso) and to correlate lesion severity with release of cardiac troponin T (cTnT) and changes in myocyte iNOS expression. Two types of cardiac injury patterns were observed. A Type I response, noted 3 or 6 hours postdosing with 8, 16, 32, or 64 mug/kg Iso, included potential reversible myocardial alterations associated with slight increases in serum cTnT (< 0.3 ng/mL) and a slight reduction in myocyte cTnT immunoreactivity. The second type of response noted 3, 6, 12, 24 or 48 hours postdosing with 125, 250, or 500 mug/kg Iso consisted of irreversible myocyte alterations, together with significant increases in serum cTnT (3-14 ng/mL) and a marked reduction of cTnT immunoreactivity. By 48 hours the hearts of rats dosed with 125-500 mug/kg Iso had developed interstitial fibrosis, and serum cTnT had declined to near control levels (0.06-0.18 ng/mL). Increases in iNOS immunoreactivity correlated with the lesion severity. These findings suggest that low doses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury. JF - Toxicologic pathology AU - Zhang, Jun AU - Knapton, Alan AU - Lipshultz, Steven E AU - Weaver, James L AU - Herman, Eugene H AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. jun.zhang@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 277 EP - 278 VL - 36 IS - 2 KW - Adrenergic beta-Antagonists KW - 0 KW - Troponin T KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, rat KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats KW - Myocytes, Cardiac -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Cell Count KW - Myocardium -- pathology KW - Dose-Response Relationship, Drug KW - Apoptosis -- drug effects KW - Injections, Subcutaneous KW - Disease Models, Animal KW - Myocytes, Cardiac -- pathology KW - Myocardium -- metabolism KW - Male KW - Immunoenzyme Techniques KW - Myocytes, Cardiac -- metabolism KW - Myocardial Infarction -- pathology KW - Myocardial Infarction -- blood KW - Troponin T -- blood KW - Adrenergic beta-Antagonists -- toxicity KW - Nitric Oxide Synthase Type II -- blood KW - Heart -- drug effects KW - Isoproterenol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Isoproterenol-induced+cardiotoxicity+in+sprague-dawley+rats%3A+correlation+of+reversible+and+irreversible+myocardial+injury+with+release+of+cardiac+troponin+T+and+roles+of+iNOS+in+myocardial+injury.&rft.au=Zhang%2C+Jun%3BKnapton%2C+Alan%3BLipshultz%2C+Steven+E%3BWeaver%2C+James+L%3BHerman%2C+Eugene+H&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-02-01&rft.volume=36&rft.issue=2&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623307313010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623307313010 ER - TY - JOUR T1 - Linkage of the National Health Interview Survey to air quality data. AN - 70418291; 18351156 AB - This report describes the linkage between the National Health Interview Survey (NHIS) and air monitoring data from the U.S. Environmental Protection Agency (EPA). There have been few linkages of these data sources, partly because of restrictions on releasing geographic detail from NHIS on public-use files in order to protect participant confidentiality. Pollution exposures for NHIS respondents were calculated by averaging the annual average exposure estimates from EPA air monitors both within 5, 10, 15, and 20 miles of the respondent's block-group location (which is available on restricted NHIS data files) and by county of residence. The 1987-2005 linked data files--referred to as NHIS-EPAAnnualAir--were used to describe the percentage of NHIS respondents linked and the median exposures by linkage method, survey year, and pollutant. Using the 2005 NHIS-EPAAnnualAir data file, the percentage linked and median exposure were described by respondent characteristics, linkage method, and pollutant. Many decisions were made to define pollution exposures for NHIS respondents, including monitor selection, location assignment for NHIS respondents, and geographic linkage criteria. Geographic linkage criteria for assigning area-level exposure estimates affected the percentage and composition of respondents included in the resulting linked sample. Median exposure estimates, however, were similar among geographic linkage methods. NHIS-EPAAnnualAir data files for 1985 through 2005 are currently available to users in the NCHS Research Data Center. JF - Vital and health statistics. Series 2, Data evaluation and methods research AU - Parker, Jennifer D AU - Kravets, Nataliya AU - Woodruff, Tracey J AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office of Analysis and Epidemiology, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1 EP - 24 IS - 145 SN - 0083-2057, 0083-2057 KW - Index Medicus KW - United States KW - United States Environmental Protection Agency KW - Humans KW - Environmental Exposure -- analysis KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Air Pollution -- analysis KW - Health Surveys KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70418291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.atitle=Linkage+of+the+National+Health+Interview+Survey+to+air+quality+data.&rft.au=Parker%2C+Jennifer+D%3BKravets%2C+Nataliya%3BWoodruff%2C+Tracey+J&rft.aulast=Parker&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=&rft.issue=145&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.issn=00832057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cleaning and other control and validation strategies to prevent allergen cross-contact in food-processing operations. AN - 70377499; 18326204 AB - Food allergies affect an estimated 10 to 12 million people in the United States. Some of these individuals can develop life-threatening allergic reactions when exposed to allergenic proteins. At present, the only successful method to manage food allergies is to avoid foods containing allergens. Consumers with food allergies rely on food labels to disclose the presence of allergenic ingredients. However, undeclared allergens can be inadvertently introduced into a food via cross-contact during manufacturing. Although allergen removal through cleaning of shared equipment or processing lines has been identified as one of the critical points for effective allergen control, there is little published information on the effectiveness of cleaning procedures for removing allergenic materials from processing equipment. There also is no consensus on how to validate or verify the efficacy of cleaning procedures. The objectives of this review were (i) to study the incidence and cause of allergen cross-contact, (ii) to assess the science upon which the cleaning of food contact surfaces is based, (iii) to identify best practices for cleaning allergenic foods from food contact surfaces in wet and dry manufacturing environments, and (iv) to present best practices for validating and verifying the efficacy of allergen cleaning protocols. JF - Journal of food protection AU - Jackson, Lauren S AU - Al-Taher, Fadwa M AU - Moorman, Mark AU - DeVries, Jonathan W AU - Tippett, Roger AU - Swanson, Katherine M J AU - Fu, Tong-Jen AU - Salter, Robert AU - Dunaif, George AU - Estes, Susan AU - Albillos, Silvia AU - Gendel, Steven M AD - U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501, USA. lauren.jackson@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 445 EP - 458 VL - 71 IS - 2 SN - 0362-028X, 0362-028X KW - Allergens KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Consumer Product Safety -- standards KW - Humans KW - Equipment Contamination -- prevention & control KW - Food Inspection KW - Food Handling -- standards KW - Food Contamination -- prevention & control KW - Disinfection -- methods KW - Food-Processing Industry -- standards KW - Food Handling -- methods KW - Food Contamination -- analysis KW - Disinfection -- standards KW - Food-Processing Industry -- methods KW - Food Hypersensitivity -- prevention & control KW - Allergens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70377499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Cleaning+and+other+control+and+validation+strategies+to+prevent+allergen+cross-contact+in+food-processing+operations.&rft.au=Jackson%2C+Lauren+S%3BAl-Taher%2C+Fadwa+M%3BMoorman%2C+Mark%3BDeVries%2C+Jonathan+W%3BTippett%2C+Roger%3BSwanson%2C+Katherine+M+J%3BFu%2C+Tong-Jen%3BSalter%2C+Robert%3BDunaif%2C+George%3BEstes%2C+Susan%3BAlbillos%2C+Silvia%3BGendel%2C+Steven+M&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2008-02-01&rft.volume=71&rft.issue=2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. AN - 70349778; 18305062 AB - On September 19, 2007, the U.S. Food and Drug Administration granted regular approval and expanded labeling for alemtuzumab (Campath); Genzyme Corporation, Cambridge, MA) as single-agent treatment for B-cell chronic lymphocytic leukemia (B-CLL). Alemtuzumab was initially approved in 2001 under accelerated approval regulations. Conversion to regular approval was based on a single study submitted to verify clinical benefit. Efficacy and safety were demonstrated in an open-label, international, multicenter, randomized trial of 297 patients with previously untreated, Rai stage I-IV B-CLL experiencing progression of their disease. Patients were randomized to either alemtuzumab, 30 mg i.v. over 2 hours three times per week on alternate days for a maximum of 12 weeks, or chlorambucil, 40 mg/m(2) orally every 28 days for a maximum of 12 months. The progression-free survival time, the primary study endpoint, was significantly longer in the alemtuzumab arm than in the chlorambucil arm. Both the overall and complete response rates were also significantly higher in the alemtuzumab arm. No differences in survival were observed. There were no new safety signals identified in patients receiving alemtuzumab. The most serious, and sometimes fatal, toxicities of alemtuzumab are cytopenias, infusion reactions, and infections. JF - The oncologist AU - Demko, Suzanne AU - Summers, Jeffrey AU - Keegan, Patricia AU - Pazdur, Richard AD - P.A.-C., U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. suzanne.demko@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 167 EP - 174 VL - 13 IS - 2 SN - 1083-7159, 1083-7159 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antineoplastic Agents KW - Antineoplastic Agents, Alkylating KW - Chlorambucil KW - 18D0SL7309 KW - alemtuzumab KW - 3A189DH42V KW - Index Medicus KW - United States KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Disease Progression KW - Aged KW - Middle Aged KW - Europe KW - Chlorambucil -- therapeutic use KW - Male KW - Female KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Antibodies, Neoplasm -- adverse effects KW - Antibodies, Neoplasm -- therapeutic use KW - Antibodies, Neoplasm -- administration & dosage KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70349778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+alemtuzumab+as+single-agent+treatment+for+B-cell+chronic+lymphocytic+leukemia.&rft.au=Demko%2C+Suzanne%3BSummers%2C+Jeffrey%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Demko&rft.aufirst=Suzanne&rft.date=2008-02-01&rft.volume=13&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2007-0218 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2007-0218 ER - TY - JOUR T1 - Drug release kinetics from stent device-based delivery systems. AN - 70316649; 18287878 AB - In an effort to overcome the limitations of balloon-expandible intravascular metal stent-induced neointimal formation, drug-coated stent devices have been developed. The stent platform allows the local delivery of drugs to an injury site, thereby reducing the amount of drug exposure to the systemic circulation and other organs. The drug carrier matrix allows the release of the drug in a diffusion-controlled manner over an extended time period after the stent implant. The drugs are chosen such that the complex cascade of events that occurs after stent implantation that leads to smooth muscle cell proliferation and migration towards the intima are inhibited. The success of an antirestenotic drug therapy from a drug-coated stent is dependent, at least partially, on the extent of drug elution from the stent, the duration and rate of release, and accumulation of drug in the arterial wall in such a way that it covers the initiation and progression of vessel wall remodeling. The local vascular drug concentrations achieved are directly correlated with the biological effects and local vascular toxicity, and there is therefore a challenge in finding an optimum dose of drug to be delivered to tissues (ie, one that has the desired therapeutic effect without local adverse effects). There is increased focus on optimization of various factors that affect drug release from the stent system, including the physicochemical properties of the drugs, carrier vehicle formulation, and profile of elution kinetics. This review highlights the various factors involved in drug release kinetics, local vascular toxicity, carrier vehicle matrix, tissue deposition, and distribution through the arterial wall from stent-based drug delivery systems. JF - Journal of cardiovascular pharmacology AU - Tesfamariam, Belay AD - Division of Cardiovascular and Renal, Center for Drug Evaluation and Research, Food & Drug Administration, Silver Spring, Maryland 20993-0002, USA. belay.tesfamariam@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 118 EP - 125 VL - 51 IS - 2 SN - 0160-2446, 0160-2446 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Drug Delivery Systems KW - Animals KW - Equipment Design KW - Humans KW - Coronary Restenosis -- prevention & control KW - Pharmacokinetics KW - Pharmaceutical Preparations -- administration & dosage KW - Pharmaceutical Preparations -- metabolism KW - Drug-Eluting Stents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70316649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Drug+release+kinetics+from+stent+device-based+delivery+systems.&rft.au=Tesfamariam%2C+Belay&rft.aulast=Tesfamariam&rft.aufirst=Belay&rft.date=2008-02-01&rft.volume=51&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/10.1097%2FFJC.0b013e318158540f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FJC.0b013e318158540f ER - TY - JOUR T1 - Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. AN - 70316193; 18273910 AB - The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/pro-oxidant tert-butylhydroquinone (tBHQ) induced two forms of the Nrf2 protein in neuroblastoma cells (IMR-32), which migrated as distinctive bands on SDS-PAGE. In vitro treatment with lambda phosphatase eliminated the slower migrating form and increased the amount of the faster migrating form of Nrf2. In vivo (32)Pi-phosphorylation resulted in (32)Pi-labeling of the Nrf2 protein in the presence of tBHQ that can be dephosphorylated by lambda phosphotase, indicating that the slower migrating form is a phosphorylated Nrf2 protein and the faster form an unphosphorylated Nrf2. Unphosphorylated Nrf2 predominated in the cytoplasm, whereas the phosphorylated form preferentially localized in the nucleus. Nuclear Nrf2 can be dephosphorylated by lambda phosphotase in vitro and be converted to the faster migrating form, implicating phosphorylation of Nrf2 in the cytoplasmic-nuclear translocation of the protein. Deletional analyses from both the carboxyl- and amino-ends revealed the transcription activation (TA) domains Neh4 (Nrf2-ECH homology 4) and Neh5 (Nrf2-ECH homology 5) as a major region necessary for the phosphorylation. The TA domains are characterized by the presence of multiple phosphorylation sites of casein kinase 2 (CK2). Moreover, CK2 phosphorylated the TA domains in vitro. Treatment with CK2 inhibitor 2-dimethylamino-4,5,6,7,-tetrabromo-1H-benzimidazole (DMAT) blocked the induction of endogenous target genes of Nrf2 in cells and inhibited the TA activities of both the full length and the TA domains of Nrf2 to a large extent. Finally, phosphorylation of the TA domains correlated with the nuclear translocation of Nrf2 that was inhibited by DMAT in a concentration-dependent manner. The findings demonstrated that phosphorylation of Nrf2 at the TA domains by CK2 is an integral component of Nrf2 activation necessary for the nuclear localization and transcription activation function of Nrf2 in neuroblastoma cells. (c) 2008 Wiley Periodicals, Inc. JF - Journal of biochemical and molecular toxicology AU - Apopa, Patrick L AU - He, Xiaoqing AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 63 EP - 76 VL - 22 IS - 1 KW - 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole KW - 0 KW - Benzimidazoles KW - NF-E2-Related Factor 2 KW - Protein Isoforms KW - Recombinant Proteins KW - Casein Kinase II KW - EC 2.7.11.1 KW - Index Medicus KW - Substrate Specificity -- drug effects KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Protein Transport -- drug effects KW - Benzimidazoles -- pharmacology KW - Humans KW - Protein Isoforms -- metabolism KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Mice KW - Phosphorylation -- drug effects KW - Conserved Sequence KW - Protein Isoforms -- chemistry KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Sequence Deletion KW - Neuroblastoma -- pathology KW - Casein Kinase II -- metabolism KW - Cell Nucleus -- metabolism KW - Transcriptional Activation -- genetics KW - Neuroblastoma -- enzymology KW - NF-E2-Related Factor 2 -- chemistry KW - Cell Nucleus -- drug effects KW - Casein Kinase II -- antagonists & inhibitors KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70316193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.atitle=Phosphorylation+of+Nrf2+in+the+transcription+activation+domain+by+casein+kinase+2+%28CK2%29+is+critical+for+the+nuclear+translocation+and+transcription+activation+function+of+Nrf2+in+IMR-32+neuroblastoma+cells.&rft.au=Apopa%2C+Patrick+L%3BHe%2C+Xiaoqing%3BMa%2C+Qiang&rft.aulast=Apopa&rft.aufirst=Patrick&rft.date=2008-02-01&rft.volume=22&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+molecular+toxicology&rft.issn=1099-0461&rft_id=info:doi/10.1002%2Fjbt.20212 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-24 N1 - Date created - 2008-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jbt.20212 ER - TY - JOUR T1 - Mycotoxins in botanicals and dried fruits: a review. AN - 70310934; 18286408 AB - Botanicals are used in many countries for medicinal and general health-promoting purposes. Numerous natural occurrences of mycotoxins in botanicals and dried fruits have been reported. Aflatoxins or ochratoxin A (OTA) have been found in botanicals such as ginseng, ginger, liquorice, turmeric, and kava-kava in the USA, Spain, Argentina, India, and some other countries, while fumonisins have been found in medicinal wild plants in South Africa and in herbal tea and medicinal plants in Turkey. Zearalenone was identified in ginseng root. Dried fruits can be contaminated with aflatoxins, OTA, kojic acid, and, occasionally, with patulin or zearalenone. One main area of concern is aflatoxins in dried figs; bright greenish yellow fluorescence under ultraviolet light is associated with aflatoxin contamination. OTA in dried vine fruits (raisins, sultanas, and currants) is another concern. There are also reports of aflatoxins in raisins and OTA in dried figs, apricots, dried plums (prunes), dates, and quince. Maximum permitted levels in the European Union include 4 microg kg(-1) for total aflatoxins in dried fruit intended for direct consumption and 10 microg kg(-1) for OTA in dried vine fruit. This review discusses the occurrence of mycotoxins in botanicals and dried fruits and analytical issues such as sampling, sample preparation, and methods for analysis. Fungal contamination of these products, the influence of sorting, storage, and processing, and prevention are also considered. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Trucksess, M W AU - Scott, P M AD - Food and Drug Administration, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 181 EP - 192 VL - 25 IS - 2 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Food Microbiology KW - Beverages -- microbiology KW - Food Preservation KW - Fruit -- microbiology KW - Food Contamination -- analysis KW - Plants, Medicinal -- microbiology KW - Mycotoxins -- analysis KW - Fruit -- chemistry KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70310934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Mycotoxins+in+botanicals+and+dried+fruits%3A+a+review.&rft.au=Trucksess%2C+M+W%3BScott%2C+P+M&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2008-02-01&rft.volume=25&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F02652030701567459 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-22 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02652030701567459 ER - TY - JOUR T1 - Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential. AN - 70301893; 18155896 AB - Over a few short years, microarray gene expression profiling has permeated most areas of biomedical research. Microarrays are now poised to enter the more demanding realm of clinical applications. The prospect of using microarray data to derive biomarkers of disease or toxicity, predict prognosis, or select treatments raises the validity and reliability bar substantially higher. The potential future payoffs are huge in terms of faster approval of more efficacious and safer medical interventions, and a more personalized implementation of them. Arriving at the future sooner rather than later is the motivation for the FDA-led MicroArray Quality Control (MAQC) project. The widespread collaboration aims to assess achievable technical performance of microarrays and capabilities and limitations of methods for microarray data analysis. JF - Current opinion in biotechnology AU - Shi, Leming AU - Perkins, Roger G AU - Fang, Hong AU - Tong, Weida AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA. leming.shi@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 10 EP - 18 VL - 19 IS - 1 SN - 0958-1669, 0958-1669 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Reproducibility of Results KW - Reference Standards KW - Gene Expression Profiling -- statistics & numerical data KW - Data Interpretation, Statistical KW - Models, Statistical KW - RNA -- standards KW - Quality Control KW - Gene Expression Profiling -- methods KW - Biotechnology KW - RNA -- genetics KW - Gene Expression Profiling -- standards KW - Oligonucleotide Array Sequence Analysis -- methods KW - Oligonucleotide Array Sequence Analysis -- statistics & numerical data KW - Oligonucleotide Array Sequence Analysis -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70301893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+biotechnology&rft.atitle=Reproducible+and+reliable+microarray+results+through+quality+control%3A+good+laboratory+proficiency+and+appropriate+data+analysis+practices+are+essential.&rft.au=Shi%2C+Leming%3BPerkins%2C+Roger+G%3BFang%2C+Hong%3BTong%2C+Weida&rft.aulast=Shi&rft.aufirst=Leming&rft.date=2008-02-01&rft.volume=19&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+biotechnology&rft.issn=09581669&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-02 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results. AN - 70289180; 18226543 AB - RNase protection assays (RPA) employing multiprobe sets are powerful tools to simultaneously measure transcription of several different genes. We used BD Biosciences/Pharmingen's mouse chemokine probeset mCK-5c to measure chemokine gene expression in brain and spleen tissue of mice. Depending on the RPA protocol used, we observed differences in the relative amounts of transcripts for interferon-inducible protein 10 (IP-10) and T-cell activation-3 (TCA-3). Isolation and sequencing of the IP-10 specific gene from the mCK-5c probeset revealed two nucleotide insertions in the probe that are not present in the natural IP-10 cDNA. We show that these insertions cause RNase A-dependent degradation of the protected IP-10 mRNA yielding a fragment indistinguishable in size from that specific for TCA-3, thus leading to over-interpretation of TCA-3 expression as well as underestimation of IP-10 gene expression levels. JF - Cytokine AU - Sauder, Christian AU - Pedras-Vasconcelos, Joao AU - Puig, Montserrat AU - Verthelyi, Daniela AD - Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C-20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA. christian.sauder@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 182 EP - 186 VL - 41 IS - 2 KW - Chemokine CCL1 KW - 0 KW - Chemokine CXCL10 KW - Cxcl10 protein, mouse KW - Reagent Kits, Diagnostic KW - Ribonuclease, Pancreatic KW - EC 3.1.27.5 KW - Index Medicus KW - Animals KW - Base Sequence KW - Sequence Alignment KW - Spleen -- metabolism KW - Molecular Sequence Data KW - Mice KW - Brain -- metabolism KW - Mice, Inbred BALB C KW - Diagnostic Errors KW - Ribonuclease, Pancreatic -- metabolism KW - Mutagenesis, Insertional KW - Female KW - Chemokine CXCL10 -- analysis KW - Chemokine CXCL10 -- genetics KW - Chemokine CCL1 -- analysis KW - Chemokine CXCL10 -- metabolism KW - Reagent Kits, Diagnostic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70289180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=The+IP10+%28CXCL10%29+specific+cDNA+probe+of+the+mCK-5c+multiprobe+RNase+protection+assay+kit+carries+two+nucleotide+insertions+that+complicate+the+interpretation+of+results.&rft.au=Sauder%2C+Christian%3BPedras-Vasconcelos%2C+Joao%3BPuig%2C+Montserrat%3BVerthelyi%2C+Daniela&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-02-01&rft.volume=41&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2007.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cyto.2007.11.009 ER - TY - JOUR T1 - Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. AN - 70286868; 18205997 AB - Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives were to compare ritonavir exposure pre- and post-GBE, and assess the effect of GBE on single doses of probe drugs midazolam and fexofenadine. This open-label study evaluated the effect of 2 weeks of standardized GBE administration on the steady-state exposure of lopinavir and ritonavir in 14 healthy volunteers administered lopinavir/ritonavir to steady-state. In addition, single oral doses of probe drugs midazolam and fexofenadine were administered prior to and after 4 weeks of GBE (following washout of lopinavir/ritonavir) to assess the influence of GBE on CYP3A and P-gp activity, respectively. Lopinavir, ritonavir and fexofenadine exposures were not significantly affected by GBE administration. However, GBE decreased midazolam AUC(0-infinity) and C(max) by 34% (p = 0.03) and 31% (p = 0.03), respectively, relative to baseline. In general, lopinavir/ritonavir and GBE were well tolerated. Abnormal laboratory results included mild elevations in hepatic enzymes, cholesterol and triglycerides, and mild-to-moderate increases in total bilirubin. Our results suggest that GBE induces CYP3A metabolism, as assessed by a decrease in midazolam concentrations. However, there was no change in the exposure of lopinavir, likely due to ritonavir's potent inhibition of CYP3A4. Thus, GBE appears unlikely to reduce the exposure of ritonavir-boosted protease inhibitors, while concentrations of unboosted protease inhibitors may be affected. Limitations to our study include the single sequence design and the evaluation of a ritonavir-boosted protease inhibitor exclusively. JF - Current medical research and opinion AU - Robertson, Sarah M AU - Davey, Richard T AU - Voell, Jocelyn AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Penzak, Scott R AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, New Hampshire Ave., Silver Spring, MD 20901, USA. sarah.robertson@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 591 EP - 599 VL - 24 IS - 2 KW - HIV Protease Inhibitors KW - 0 KW - P-Glycoprotein KW - Plant Extracts KW - Protease Inhibitors KW - Pyrimidinones KW - Lopinavir KW - 2494G1JF75 KW - Terfenadine KW - 7BA5G9Y06Q KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - fexofenadine KW - E6582LOH6V KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Ritonavir KW - O3J8G9O825 KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Drug Interactions KW - P-Glycoprotein -- metabolism KW - Humans KW - Adult KW - Cytochrome P-450 Enzyme System -- metabolism KW - Male KW - Female KW - Phytotherapy KW - Terfenadine -- analogs & derivatives KW - Protease Inhibitors -- pharmacokinetics KW - Ritonavir -- pharmacokinetics KW - Plant Extracts -- metabolism KW - Midazolam -- pharmacokinetics KW - Terfenadine -- pharmacokinetics KW - Pyrimidinones -- pharmacokinetics KW - HIV Protease Inhibitors -- pharmacology KW - Ginkgo biloba -- metabolism KW - Ginkgo biloba -- adverse effects KW - Plant Extracts -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70286868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Effect+of+Ginkgo+biloba+extract+on+lopinavir%2C+midazolam+and+fexofenadine+pharmacokinetics+in+healthy+subjects.&rft.au=Robertson%2C+Sarah+M%3BDavey%2C+Richard+T%3BVoell%2C+Jocelyn%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BPenzak%2C+Scott+R&rft.aulast=Robertson&rft.aufirst=Sarah&rft.date=2008-02-01&rft.volume=24&rft.issue=2&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=1473-4877&rft_id=info:doi/10.1185%2F030079908X260871 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-28 N1 - Date created - 2008-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1185/030079908X260871 ER - TY - JOUR T1 - Microbiological quality of bagged cut spinach and lettuce mixes. AN - 70284816; 18156327 AB - Analysis of 100 bagged lettuce and spinach samples showed mean total bacterial counts of 7.0 log(10) CFU/g and a broad range of or = 11,000/g coliforms were found in 55 samples, and generic Escherichia coli bacteria were detected in 16 samples, but no E. coli count exceeded 10 MPN/g. JF - Applied and environmental microbiology AU - Valentin-Bon, Iris AU - Jacobson, Andrew AU - Monday, Steven R AU - Feng, Peter C H AD - Division of Microbiology, United States Food and Drug Administration, College Park, Maryland 20740, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1240 EP - 1242 VL - 74 IS - 4 KW - Index Medicus KW - Colony Count, Microbial KW - Lettuce -- microbiology KW - Food Microbiology KW - Enterobacteriaceae -- isolation & purification KW - Spinacia oleracea -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70284816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Microbiological+quality+of+bagged+cut+spinach+and+lettuce+mixes.&rft.au=Valentin-Bon%2C+Iris%3BJacobson%2C+Andrew%3BMonday%2C+Steven+R%3BFeng%2C+Peter+C+H&rft.aulast=Valentin-Bon&rft.aufirst=Iris&rft.date=2008-02-01&rft.volume=74&rft.issue=4&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-18 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Food Microbiol. 2000 Jun 30;58(1-2):123-8 [10898470] Lett Appl Microbiol. 2001 Dec;33(6):434-9 [11737627] J Food Prot. 2003 Mar;66(3):403-9 [12636292] J Food Prot. 2003 Sep;66(9):1581-6 [14503709] J Food Prot. 2004 May;67(5):894-900 [15151224] J Food Prot. 2007 May;70(5):1277-80 [17536694] J Food Prot. 1998 Mar;61(3):357-9 [9708311] J Food Prot. 2005 Sep;68(9):1840-7 [16161682] MMWR Morb Mortal Wkly Rep. 2006 Sep 29;55(38):1045-6 [17008868] Int J Food Microbiol. 2006 Nov 1;112(2):83-95 [17045687] J Food Prot. 2004 Oct;67(10):2342-53 [15508656] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of dietary components on chicken immune system and Salmonella infection. AN - 70269829; 18251669 AB - Salmonella enterica serovars are facultative intracellular pathogens that may cause serious illness in poultry and humans. Human infection by two common serovars, Salmonella enteritidis (SE) and Salmonella typhimurium (ST) usually occurs via food-borne transmission. Consumption of raw or undercooked contaminated eggs usually causes SE infection, while ST is transmitted by contaminated chicken meat. There are several reports on dietary interventions, including fatty acid modifications, probiotic or prebiotic treatment on the immune system and/or Salmonella clearance in chickens. The aim of this review is to compile the information on the role of major dietary components on chicken immune system and Salmonella clearance. This may help design better poultry nutrition to lower Salmonella infection in chickens and, therefore, reduce human salmonellosis. JF - Expert review of anti-infective therapy AU - Babu, Uma S AU - Raybourne, Richard B AD - Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. uma.babu@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 121 EP - 135 VL - 6 IS - 1 KW - Dietary Proteins KW - 0 KW - Index Medicus KW - Animals KW - Chickens KW - Salmonella Food Poisoning -- prevention & control KW - Humans KW - Salmonella Food Poisoning -- immunology KW - Salmonella Infections -- prevention & control KW - Probiotics -- therapeutic use KW - Salmonella Food Poisoning -- transmission KW - Salmonella Infections -- immunology KW - Dietary Proteins -- therapeutic use KW - Salmonella Infections -- transmission KW - Diet -- methods KW - Salmonella Infections, Animal -- transmission KW - Salmonella Infections, Animal -- prevention & control KW - Salmonella Infections, Animal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+anti-infective+therapy&rft.atitle=Impact+of+dietary+components+on+chicken+immune+system+and+Salmonella+infection.&rft.au=Babu%2C+Uma+S%3BRaybourne%2C+Richard+B&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2008-02-01&rft.volume=6&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+anti-infective+therapy&rft.issn=1744-8336&rft_id=info:doi/10.1586%2F14787210.6.1.121 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/14787210.6.1.121 ER - TY - JOUR T1 - Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. AN - 70269074; 18157835 AB - Herbal products, used for centuries in Far Eastern countries, are gaining popularity in western countries. Surveys indicate that persons with chronic hepatitis C (CHC) often use herbals, especially silymarin (milk thistle extract), hoping to improve the modest response to antiviral therapy and reduce side effects. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, involving persons with advanced CHC, nonresponders to prior antiviral therapy but still willing to participate in long-term pegylated interferon treatment, offered the opportunity to examine the use and potential effects of silymarin. Among 1145 study participants, 56% had never taken herbals, 21% admitted past use, and 23% were using them at enrollment. Silymarin constituted 72% of 60 herbals used at enrollment. Among all participants, 67% had never used silymarin, 16% used it in the past, and 17% used it at baseline. Silymarin use varied widely among the 10 participating study centers; men were more frequent users than women, as were non-Hispanic whites than African Americans and Hispanics. Silymarin use correlated strongly with higher education. No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels. Univariate analysis showed significantly fewer liver-related symptoms and better quality-of-life parameters in users than nonusers, but after reanalysis adjusted for covariates of age, race, education, alcohol consumption, exercise, body mass index, and smoking, only fatigue, nausea, liver pain, anorexia, muscle and joint pain, and general health remained significantly better in silymarin users. In conclusion, silymarin users had similar alanine aminotransferase and HCV levels to those of nonusers but fewer symptoms and somewhat better quality-of-life indices. Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C. JF - Hepatology (Baltimore, Md.) AU - Seeff, Leonard B AU - Curto, Teresa M AU - Szabo, Gyongyi AU - Everson, Gregory T AU - Bonkovsky, Herbert L AU - Dienstag, Jules L AU - Shiffman, Mitchell L AU - Lindsay, Karen L AU - Lok, Anna S F AU - Di Bisceglie, Adrian M AU - Lee, William M AU - Ghany, Marc G AU - HALT-C Trial Group AD - Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. seeffl@extra.niddk.nih.gov ; HALT-C Trial Group Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 605 EP - 612 VL - 47 IS - 2 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Silymarin KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Antiviral Agents -- therapeutic use KW - Silymarin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Silymarin -- adverse effects KW - Polyethylene Glycols -- therapeutic use KW - Humans KW - Interviews as Topic KW - Biopsy KW - Patient Selection KW - Liver Function Tests KW - Liver Cirrhosis -- prevention & control KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Herbal Medicine -- statistics & numerical data KW - Hepatitis C, Chronic -- therapy KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Herbal+product+use+by+persons+enrolled+in+the+hepatitis+C+Antiviral+Long-Term+Treatment+Against+Cirrhosis+%28HALT-C%29+Trial.&rft.au=Seeff%2C+Leonard+B%3BCurto%2C+Teresa+M%3BSzabo%2C+Gyongyi%3BEverson%2C+Gregory+T%3BBonkovsky%2C+Herbert+L%3BDienstag%2C+Jules+L%3BShiffman%2C+Mitchell+L%3BLindsay%2C+Karen+L%3BLok%2C+Anna+S+F%3BDi+Bisceglie%2C+Adrian+M%3BLee%2C+William+M%3BGhany%2C+Marc+G%3BHALT-C+Trial+Group&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2008 Jul;48(1):345-6 [18509876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nationwide Evaluation of X-Ray Trends. AN - 70261294; 18242533 JF - Journal of the American College of Radiology : JACR AU - Spelic, David C AD - US Food and Drug Administration, Division of Mammography Quality and Radiation Programs, 1350 Piccard Drive, HFZ-240, Rockville, MD 20850, USA. david.spelic@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 146 EP - 148 VL - 5 IS - 2 KW - Index Medicus KW - United States KW - Humans KW - Body Burden KW - Practice Patterns, Physicians' -- trends KW - Radiography -- statistics & numerical data KW - Health Care Surveys -- methods KW - Radiography -- trends KW - Practice Patterns, Physicians' -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70261294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Radiology+%3A+JACR&rft.atitle=Nationwide+Evaluation+of+X-Ray+Trends.&rft.au=Spelic%2C+David+C&rft.aulast=Spelic&rft.aufirst=David&rft.date=2008-02-01&rft.volume=5&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Radiology+%3A+JACR&rft.issn=1558-349X&rft_id=info:doi/10.1016%2Fj.jacr.2007.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jacr.2007.11.003 ER - TY - JOUR T1 - Smoking in the home and children's health. AN - 70243388; 18218804 AB - We estimate for young children the annual excess health service use, healthcare expenditures, and disability bed days for respiratory conditions associated with exposure to smoking in the home in the United States. Health service use, healthcare expenditures and disability bed days data come from the 1999 and 2001 Medical Expenditure Panel Survey (MEPS). Reported smoking in the home comes from the linked National Health Interview Survey, from which the MEPS sample is drawn. Multivariate statistical analysis controls for potential confounding factors. The sample is 2759 children aged 0-4. Smoking in the home is associated with an increase in the probability of emergency department visits for respiratory conditions by five percentage points and the probability of inpatient use for these conditions by three percentage points. There is no relation between indoor smoking by adults and either ambulatory visits or prescription drug expenditures. Overall, indoor smoking is associated with $117 in additional healthcare expenditures for respiratory conditions for each exposed child aged 0-4. Indoor smoking is also associated with an eight percentage point increase in the probability of having a bed day because of respiratory illness for children aged 1-4. Despite the significant progress made in tobacco control, many children are still exposed to secondhand smoke in their home. Reducing exposure to smoking in the home would probably reduce healthcare expenditures for respiratory conditions and improve children's health. JF - Tobacco control AU - Hill, S C AU - Liang, L AD - Center for Financing, Cost and Access Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 32 EP - 37 VL - 17 IS - 1 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Asthma -- epidemiology KW - Humans KW - Infant, Newborn KW - Bronchitis -- economics KW - Child, Preschool KW - Infant KW - Bronchitis -- epidemiology KW - Risk Factors KW - United States -- epidemiology KW - Asthma -- economics KW - Female KW - Male KW - Prevalence KW - Health Services Needs and Demand -- utilization KW - Tobacco Smoke Pollution -- economics KW - Tobacco Smoke Pollution -- adverse effects KW - Emergency Service, Hospital -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70243388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Smoking+in+the+home+and+children%27s+health.&rft.au=Hill%2C+S+C%3BLiang%2C+L&rft.aulast=Hill&rft.aufirst=S&rft.date=2008-02-01&rft.volume=17&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftc.2007.020990 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tc.2007.020990 ER - TY - JOUR T1 - Animal models for probing the developmental basis of disease and dysfunction paradigm. AN - 70237548; 18226058 AB - There is a major paradigm shift taking place in science that while simple is profound. The new paradigm suggests that susceptibility to disease is set in utero or neonatally as a result of the influences of nutrition and exposures to environmental stressors/toxicants. In utero nutrition and/or in utero or neonatal exposures to environmental toxicants alter susceptibility to disease later in life as a result of their ability to affect the programming of tissue function that occurs during development. This concept, which is still a hypothesis undergoing scientific testing and scrutiny, is called the developmental basis of health and disease. If true, then it says that the focus on disease prevention and intervention must change from the time of disease onset to perhaps decades prior: during the in utero and neonatal period. Perhaps the reason it has been so difficult to link environmental exposure to disease susceptibility is that scientists have been looking at the wrong time! Certainly, not all exposures that result in increased disease or dysfunction occur during development. This paradigm shift just suggests that this is a sensitive window of exposure that should be examined more thoroughly. This overview focuses on animal models for the assessment of this new scientific paradigm and the animal data that now supports it. JF - Basic & clinical pharmacology & toxicology AU - Heindel, Jerrold J AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. heindelj@niehs.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 76 EP - 81 VL - 102 IS - 2 KW - Environmental Pollutants KW - 0 KW - Phthalic Acids KW - Index Medicus KW - Gene Expression -- drug effects KW - Parkinson Disease, Secondary -- chemically induced KW - Animals KW - Environmental Pollutants -- toxicity KW - Adenocarcinoma -- chemically induced KW - Humans KW - Epigenesis, Genetic KW - Phthalic Acids -- toxicity KW - Pregnancy KW - Obesity -- etiology KW - Sperm Count KW - Neoplasms -- chemically induced KW - Leiomyoma -- chemically induced KW - Chronic Disease KW - Female KW - Fertility -- drug effects KW - Models, Animal KW - Maternal-Fetal Exchange KW - Environmental Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70237548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+clinical+pharmacology+%26+toxicology&rft.atitle=Animal+models+for+probing+the+developmental+basis+of+disease+and+dysfunction+paradigm.&rft.au=Heindel%2C+Jerrold+J&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2008-02-01&rft.volume=102&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Basic+%26+clinical+pharmacology+%26+toxicology&rft.issn=1742-7843&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00184.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-22 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1742-7843.2007.00184.x ER - TY - JOUR T1 - Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. AN - 70236483; 18091565 AB - In the industrialized world, lymphogranuloma venereum proctitis (LGVP) has been reported only in men who have sex with men. Factors responsible for the outbreak remain to be elucidated. The goal of the present work was to elucidate risk factors associated with LGVP. The study design comprised a cross-sectional study including 32 men with LGVP and 93 men without LGVP (22 with gonorrheal proctitis, 30 with a non-LGV chlamydial proctitis, and 41 with proctitis of unknown etiology). Factors associated with LGVP were analyzed by (multinomial) logistic regression. Comparing men with LGVP with men without LGVP, factors significantly associated with higher risk of LGVP in multivariate analyses were as follows: anal enema use [odds ratio (OR): 7.8, 95% confidence interval (CI): 2.6-23.2], having sex on sex parties (OR: 5.7, 95% CI: 1.5-21.8), and having sex with human immunodeficiency virus-positive partners (OR: 3.2, 95% CI: 1.1-9.3). Evaluating the 4 proctitis groups separately in a multinomial logistic regression model, similar associations between anal enema use and LGVP were found. Men with non-LGV chlamydial proctitis showed less risk behavior than men with LGVP. No substantial difference in risk behavior was found, except for attending sex parties, between men with LGVP, and gonorrheal proctitis or proctitis of unknown etiology. Apart from men with LGVP, men with gonorrheal proctitis or proctitis of unknown etiology exhibit high risk behavior. Enema use seems to play a key role in transmission of LGVP, and needs further investigation. JF - Sexually transmitted diseases AU - de Vries, Henry J C AU - van der Bij, Akke K AU - Fennema, Johan S A AU - Smit, Colette AU - de Wolf, Frank AU - Prins, Maria AU - Coutinho, Roel A AU - Morré, Servaas A AD - STI Outpatient Clinic, Cluster Infectious Diseases, Public Health Service Amsterdam. The Netherlands. h.j.devries@amc.nl Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 203 EP - 208 VL - 35 IS - 2 SN - 0148-5717, 0148-5717 KW - Index Medicus KW - Netherlands -- epidemiology KW - Cross-Sectional Studies KW - Unsafe Sex KW - Logistic Models KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Lymphogranuloma Venereum -- diagnosis KW - Homosexuality, Male KW - Risk Factors KW - Proctitis -- epidemiology KW - Enema -- adverse effects KW - Proctitis -- etiology KW - Lymphogranuloma Venereum -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70236483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=Lymphogranuloma+venereum+proctitis+in+men+who+have+sex+with+men+is+associated+with+anal+enema+use+and+high-risk+behavior.&rft.au=de+Vries%2C+Henry+J+C%3Bvan+der+Bij%2C+Akke+K%3BFennema%2C+Johan+S+A%3BSmit%2C+Colette%3Bde+Wolf%2C+Frank%3BPrins%2C+Maria%3BCoutinho%2C+Roel+A%3BMorr%C3%A9%2C+Servaas+A&rft.aulast=de+Vries&rft.aufirst=Henry+J&rft.date=2008-02-01&rft.volume=35&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=01485717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone. AN - 70235410; 17974624 AB - Although estrogen has effects on the heart, little is known regarding which genes in the heart are directly responsive to estrogen. We have shown previously that lipoprotein lipase (LPL) expression was increased in female hearts compared with male hearts. To test whether LPL gene expression in heart is regulated by estrogen, we perfused mouse hearts from ovariectomized females with 100 nM 17beta-estradiol or vehicle for 2 h, after which hearts were frozen, and RNA was isolated. The SYBR green real-time PCR method was used to detect LPL gene expression. We found that addition of 17beta-estradiol to hearts from ovariectomized females resulted in a significant increase in LPL mRNA. This estrogen effect on LPL gene expression in mouse heart can be blocked by the estrogen receptor (ER) antagonist ICI 182,780 or by progesterone. We also identified a potential estrogen receptor element (ERE) enhancer sequence located in the first intron of the mouse LPL gene. The potential ERE sequence was linked to a TATA-luciferase (LUC) reporter plasmid in HeLa cells. Both ERalpha and ERbeta stimulated strong activity on the heterologous promoter reporter in Hela cells upon estrogen addition. Both ERalpha and ERbeta activities on the LPL ERE reporter were abrogated by the ER antagonist ICI 182,780. Progesterone also dose dependently inhibited the estrogen-mediated increase in LPL ERE reporter activity. These results show that heart LPL is an estrogen-responsive gene exhibiting an intronic regulatory sequence. JF - Endocrinology AU - Liu, Dianxin AU - Deschamps, Anne AU - Korach, Kenneth S AU - Murphy, Elizabeth AD - Laboratories of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 711 EP - 716 VL - 149 IS - 2 SN - 0013-7227, 0013-7227 KW - RNA, Messenger KW - 0 KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Interactions KW - Introns -- physiology KW - RNA, Messenger -- metabolism KW - HeLa Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Mice, Inbred C57BL KW - Genes, Reporter KW - Ovariectomy KW - Mice KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Progesterone -- pharmacology KW - Lipoprotein Lipase -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Myocardium -- enzymology KW - Estradiol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70235410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Estrogen-enhanced+gene+expression+of+lipoprotein+lipase+in+heart+is+antagonized+by+progesterone.&rft.au=Liu%2C+Dianxin%3BDeschamps%2C+Anne%3BKorach%2C+Kenneth+S%3BMurphy%2C+Elizabeth&rft.aulast=Liu&rft.aufirst=Dianxin&rft.date=2008-02-01&rft.volume=149&rft.issue=2&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Cell Cardiol. 2005 Feb;38(2):289-97 [15698835] Lipids. 1994 May;29(5):333-6 [8015363] J Biol Chem. 2006 Mar 31;281(13):8716-23 [16410253] FASEB J. 2006 May;20(7):926-34 [16675850] J Biol Chem. 2006 Sep 8;281(36):26683-92 [16847062] Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R800-9 [17008461] J Mol Endocrinol. 2000 Feb;24(1):145-55 [10657006] Circulation. 2001 Sep 18;104(12):1419-23 [11560859] FEBS Lett. 2001 Aug 3;502(3):103-8 [11583108] Am Heart J. 1996 Aug;132(2 Pt 1):258-62 [8701884] Circulation. 1997 Jan 7;95(1):252-64 [8994444] Circ Res. 1998 Dec 14-28;83(12):1215-23 [9851938] Mol Endocrinol. 1999 Mar;13(3):485-94 [10077005] Circulation. 2004 Nov 16;110(20):3270-5 [15533858] Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H469-76 [15374829] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E331-9 [12388125] J Clin Invest. 2003 Feb;111(3):419-26 [12569168] Metabolism. 2003 Apr;52(4):383-8 [12701046] J Pharmacol Exp Ther. 2003 Oct;307(1):395-401 [12893838] Hypertension. 2003 Oct;42(4):781-6 [12874087] Atherosclerosis. 2003 Dec;171(2):343-50 [14644406] J Biol Chem. 2004 Jun 11;279(24):25050-7 [15028738] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14234-9 [15375213] Biochim Biophys Acta. 1993 Aug 11;1169(2):107-25 [8343535] Circulation. 2005 Mar 29;111(12):1492-8 [15781739] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. AN - 70202533; 17487226 AB - Previous studies have shown that the dopamine (DA) uptake blocker methylphenidate, a psychostimulant widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), prevents the neurotoxic effects of the highly abused DA releaser methamphetamine. However, there is a lack of information about the pharmacological interactions of these two drugs at the behavioral level. When systemically administered within an interval of 2 h, previous administration of methylphenidate (10 mg/kg, intraperitoneal (i.p.)) did not modify locomotor activation induced by methamphetamine. On the other hand, previous administration of methamphetamine (1 mg/kg, i.p.) markedly potentiated methylphenidate-induced motor activation. With in vivo microdialysis experiments, methamphetamine and methylphenidate were found to increase DA extracellular levels in the nucleus accumbens (NAs). Methamphetamine, but not methylphenidate, significantly increased the extracellular levels of serotonin (5-HT) in the NAs. Methamphetamine-induced 5-HT release remained significantly elevated for more than 2 h after its administration, suggesting that the increased 5-HT could be responsible for the potentiation of methylphenidate-induced locomotor activation. In fact, previous administration of the 5-HT uptake blocker fluoxetine (10 mg/kg, i.p.) also potentiated the motor activation induced by methylphenidate. A selective 5-HT 1B receptor antagonist (GR 55562; 1 mg/kg), but not a 5-HT2 receptor antagonist (ritanserin; 2 mg/kg, i.p.), counteracted the effects of methamphetamine and fluoxetine on the motor activation induced by methylphenidate. Furthermore, a 5-HT 1B receptor agonist (CP 94253; 1-10 mg/kg, i.p.) strongly and dose-dependently potentiated methylphenidate-induced locomotor activation. The 5-HT 1B receptor-mediated modulation of methylphenidate-induced locomotor activation in rat could have implications for the treatment of ADHD. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Borycz, Janusz AU - Zapata, Agustin AU - Quiroz, César AU - Volkow, Nora D AU - Ferré, Sergi AD - Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 619 EP - 626 VL - 33 IS - 3 SN - 0893-133X, 0893-133X KW - CP 94253 KW - 0 KW - Central Nervous System Stimulants KW - Pyridines KW - Receptor, Serotonin, 5-HT1B KW - Serotonin Receptor Agonists KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Methylphenidate KW - 207ZZ9QZ49 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Fluoxetine -- pharmacology KW - Dose-Response Relationship, Drug KW - Nucleus Accumbens -- drug effects KW - Dopamine -- metabolism KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Extracellular Space -- metabolism KW - Methamphetamine -- pharmacology KW - Nucleus Accumbens -- metabolism KW - Serotonin Uptake Inhibitors -- pharmacology KW - Extracellular Space -- drug effects KW - Pyridines -- pharmacology KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Serotonin -- physiology KW - Methylphenidate -- pharmacology KW - Receptor, Serotonin, 5-HT1B -- physiology KW - Motor Activity -- drug effects KW - Serotonin -- metabolism KW - Receptor, Serotonin, 5-HT1B -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=5-HT+1B+receptor-mediated+serotoninergic+modulation+of+methylphenidate-induced+locomotor+activation+in+rats.&rft.au=Borycz%2C+Janusz%3BZapata%2C+Agustin%3BQuiroz%2C+C%C3%A9sar%3BVolkow%2C+Nora+D%3BFerr%C3%A9%2C+Sergi&rft.aulast=Borycz&rft.aufirst=Janusz&rft.date=2008-02-01&rft.volume=33&rft.issue=3&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of probiotic substances as ingredients in foods: premarket approval or "generally recognized as safe" notification. AN - 70196730; 18181714 AB - This article discusses options and examples of regulations or "generally recognized as safe" determinations that are related to microorganisms in food. A balanced picture of information about the microorganism and its characteristics is needed to make conclusions about its safety. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mattia, Antonia AU - Merker, Robert AD - Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740, USA. antonia.mattia@fda.hhs.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - S115 EP - 8; discussion S144-51 VL - 46 Suppl 2 KW - Index Medicus KW - United States KW - Humans KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Legislation, Drug KW - Food Industry -- standards KW - Food Microbiology -- standards KW - Consumer Product Safety -- standards KW - Food Microbiology -- legislation & jurisprudence KW - Food Industry -- legislation & jurisprudence KW - Food, Organic -- standards KW - Probiotics -- therapeutic use KW - Consumer Product Safety -- legislation & jurisprudence KW - Probiotics -- standards KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70196730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Regulation+of+probiotic+substances+as+ingredients+in+foods%3A+premarket+approval+or+%22generally+recognized+as+safe%22+notification.&rft.au=Mattia%2C+Antonia%3BMerker%2C+Robert&rft.aulast=Mattia&rft.aufirst=Antonia&rft.date=2008-02-01&rft.volume=46+Suppl+2&rft.issue=&rft.spage=S115&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F523329 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/523329 ER - TY - JOUR T1 - The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals. AN - 70159777; 18069108 AB - The use of transgenic rodents may overcome many limitations of traditional cancer studies. Regulatory perspectives continue to evolve as new models are developed and validated. The transgenic mouse, K6/ODC, develops epidermal tumors when exposed to genotoxic carcinogens. In this study, K6/ODC mice were evaluated for model fitness and health robustness in a 36-week study to determine oncogenic risk of residual DNA in vaccines from neoplastic cell substrates. K6/ODC and C57BL/6 mice were treated with T24-H-ras expression plasmid, carrier vector DNA, or saline topically or by subcutaneous injection. One group of K6/ODC mice received 7,12-dimethylbenz-[a]anthracene [DMBA] dermally. Only DMBA-treated mice developed papillomas by six weeks, increasing in incidence to 25 weeks. By week 11, many K6/ODC mice showed severe dehydration and dermal eczema. By week 32, (6/8) surviving K6/ODC mice showed loss of mobility and balance. Microscopic evaluation of tissues revealed dermal/sebaceous gland hyperplasia, follicular dystrophy, splenic atrophy, and amyloid deposition/neutrophilic infiltration within liver, heart, and spleen, in all K6/ODC mice. Pathology was not detected in C57BL/6 mice. Progressive adverse health, decreased survival, and failure to develop papillomas to the H-ras plasmid suggest that K6/ODC mice may be an inappropriate alternative model for detection of oncogenic DNA and pharmaceutical carcinogenicity testing. JF - Regulatory toxicology and pharmacology : RTP AU - Miller, T J AU - Honchel, R AU - Espandiari, P AU - Knapton, A AU - Zhang, J AU - Sistare, F D AU - Hanig, J P AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. terry.miller@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 87 EP - 97 VL - 50 IS - 1 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Keratin-6 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Carcinogens -- administration & dosage KW - Kidney -- pathology KW - 9,10-Dimethyl-1,2-benzanthracene -- administration & dosage KW - Drug-Related Side Effects and Adverse Reactions KW - Kidney -- drug effects KW - Spleen -- pathology KW - Mice KW - Sarcoma Viruses, Murine -- genetics KW - Mice, Transgenic KW - Transfection KW - Liver -- drug effects KW - Carcinogenicity Tests -- methods KW - Mice, Inbred C57BL KW - Spleen -- drug effects KW - Male KW - Ornithine Decarboxylase -- genetics KW - Keratin-6 -- genetics KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- pathology KW - Disease Models, Animal KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+utility+of+the+K6%2FODC+transgenic+mouse+as+an+alternative+short+term+dermal+model+for+carcinogenicity+testing+of+pharmaceuticals.&rft.au=Miller%2C+T+J%3BHonchel%2C+R%3BEspandiari%2C+P%3BKnapton%2C+A%3BZhang%2C+J%3BSistare%2C+F+D%3BHanig%2C+J+P&rft.aulast=Miller&rft.aufirst=T&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of immunochemical and biosensor methods for occupational and environmental monitoring. Part I: introduction to immunoassays. AN - 70101871; 18074291 JF - Journal of occupational and environmental hygiene AU - Ashley, Kevin AU - Biagini, Raymond E AU - Smith, Jerry P AU - Sammons, Deborah L AU - Mackenzie, Barbara A AU - Striley, Cynthia A F AU - Robertson, Shirley K AU - Snawder, John E AD - Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control andPrevention, Cincinnati, Ohio, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - D25 EP - D32 VL - 5 IS - 2 KW - Antigen-Antibody Complex KW - 0 KW - Antigens KW - Immunoglobulin Isotypes KW - Pesticide Residues KW - Index Medicus KW - Pesticide Residues -- immunology KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Antigen-Antibody Complex -- immunology KW - Immunoglobulin Isotypes -- chemistry KW - Fluorescent Antibody Technique -- methods KW - Enzyme-Linked Immunosorbent Assay -- instrumentation KW - Pesticide Residues -- analysis KW - Immunoglobulin Isotypes -- immunology KW - Antigens -- immunology KW - Microspheres KW - Immunoassay -- methods KW - Biosensing Techniques -- methods KW - Biosensing Techniques -- instrumentation KW - Environmental Monitoring -- methods KW - Immunoassay -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70101871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+use+of+immunochemical+and+biosensor+methods+for+occupational+and+environmental+monitoring.+Part+I%3A+introduction+to+immunoassays.&rft.au=Ashley%2C+Kevin%3BBiagini%2C+Raymond+E%3BSmith%2C+Jerry+P%3BSammons%2C+Deborah+L%3BMackenzie%2C+Barbara+A%3BStriley%2C+Cynthia+A+F%3BRobertson%2C+Shirley+K%3BSnawder%2C+John+E&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=5&rft.issue=2&rft.spage=D25&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation and characterization of tetracycline-resistant Citrobacter spp. from catfish. AN - 70098755; 17993380 AB - Fifty-two tetracycline-resistant Citrobacter spp. strains were isolated from farm-raised catfish. Morphological and biochemical characteristics indicated that 38 of the 52 citrobacters were Citrobacter freundii, 7 were C. amalonaticus and 7 were C. braakii. All isolates were resistant to multiple antibiotics. Polymerase chain reaction (PCR) protocols were developed to detect the presence of 3 tetracycline-resistance genes (tetA, tetB and tetG) from Citrobacter isolates. Oligonucleotide primers specifically targeting a 967-bp region of tetB successfully amplified the PCR amplicons from 3238 (85.0%) of C. freundii strains, 57 (71.0%) of C. amalonaticus and 47 (57%) from C. braakii. Oligonucleotide primers specific for the detection of tetA gene amplified the 417-bp PCR amplicons from 738 (18.0%) of tetracycline-resistant C. freundii only. The assay failed to amplify tetA genes from C. brakii or C. amalonaticus. Plasmids (2.0-16.0kb) were isolated from 14 of the 38 strains of C. freundii. Strains of C. amalonaticus and C. brakii did not contain any plasmids. Dendrogram analysis of the SpeI pulsed field gel electrophoresis (PFGE) results identified 23 distinct macrorestriction patterns (mrps) among the 36 strains of C. freundii, 3 distinct mrps among the 7 strains of C. braakii and 4 unique mrps among the 7 strains of C. amalonaticus. Our results indicate that citrobacters from catfish could serve as reservoirs of tetracycline-resistance determinants. JF - Food microbiology AU - Nawaz, Mohamed AU - Khan, Ashraf A AU - Khan, Saeed AU - Sung, Kidon AU - Steele, Roger AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, USA. mohamed.nawaz@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 85 EP - 91 VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - DNA Primers KW - 0 KW - Index Medicus KW - Animals KW - Consumer Product Safety KW - Drug Resistance, Multiple, Bacterial -- genetics KW - Humans KW - Polymerase Chain Reaction -- methods KW - Electrophoresis, Gel, Pulsed-Field KW - Plasmids KW - Species Specificity KW - Microbial Sensitivity Tests KW - Gene Amplification KW - Tetracycline Resistance -- genetics KW - Citrobacter -- drug effects KW - Catfishes -- microbiology KW - Citrobacter -- isolation & purification KW - Food Contamination -- analysis KW - Citrobacter -- classification KW - Seafood -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70098755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Isolation+and+characterization+of+tetracycline-resistant+Citrobacter+spp.+from+catfish.&rft.au=Nawaz%2C+Mohamed%3BKhan%2C+Ashraf+A%3BKhan%2C+Saeed%3BSung%2C+Kidon%3BSteele%2C+Roger&rft.aulast=Nawaz&rft.aufirst=Mohamed&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=07400020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of scaffold end frame carrying strategies on worker stepping response, postural stability, and perceived task difficulty. AN - 68565071; 18354969 AB - OBJECTIVE This study determined the most favorable strategy for carrying scaffold end frames while minimizing the risk of injuries from being struck by an object, falling, and overexertion. BACKGROUND Scaffold erectors are at risk of high exposure to the aforementioned hazards associated with the dynamic human-scaffolding interface and work environments. Identifying an optimal work strategy can help reduce risk of injuries to the worker. METHOD Three carrying methods, four types of work surfaces, two weights of scaffold frames, and three directions of stepping movement were tested in a laboratory with 18 construction workers. RESULTS The effects of carrying method on postural instability and task difficulty rating were significant for handling the 22-kg end frame. Response time, postural instability, and perceived task difficulty rating were significantly reduced when the 9-kg end frame was used as compared with the 22-kg frame. CONCLUSION The symmetric side-carrying method was the best option for handling 22-kg scaffold end frames. A 9-kg end frame (e.g., made of reinforced lightweight materials) has the potential to reduce injury risk among scaffold handlers during their scaffold erection and dismantlingjobs. APPLICATION Scaffold erectors may want to adopt the symmetric side-carrying method as the primary technique for handling the 22-kg scaffold end frame, which is currently the one most used in the industry. JF - Human factors AU - Hsiao, Hongwei AU - Hause, Mathew AU - Powers, John R AU - Kau, Tsui-Ying AU - Hendricks, Scott AU - Simeonov, Peter I AD - Protective Technology Branch, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA. hhsiao@cdc.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 27 EP - 36 VL - 50 IS - 1 SN - 0018-7208, 0018-7208 KW - Index Medicus KW - Space life sciences KW - United States KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Altitude KW - Humans KW - Adult KW - Task Performance and Analysis KW - Middle Aged KW - Male KW - Postural Balance KW - Walking KW - Facility Design and Construction KW - Lifting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68565071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+factors&rft.atitle=Effect+of+scaffold+end+frame+carrying+strategies+on+worker+stepping+response%2C+postural+stability%2C+and+perceived+task+difficulty.&rft.au=Hsiao%2C+Hongwei%3BHause%2C+Mathew%3BPowers%2C+John+R%3BKau%2C+Tsui-Ying%3BHendricks%2C+Scott%3BSimeonov%2C+Peter+I&rft.aulast=Hsiao&rft.aufirst=Hongwei&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Human+factors&rft.issn=00187208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-03-21 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Behavioral problems following reunification of children in long-term foster care AN - 61426850; 200907659 AB - Although reunification is the most common and preferred exit from the U.S. foster care system, little is known about the well-being of children following foster care. Even less is known about reunification following long-term foster care. Geographically limited studies suggest poor behavioral outcomes following reunification. A secondary data analysis was performed using a subsample of 604 children from the National Study of Child and Adolescent Well-being (NSCAW) who had experienced at least 8 months of foster care. Multiple imputation (MI) was employed to address missing data. Descriptive statistics, logistic regression, and propensity score matching are used to explore the role of risks and reunification in children's well-being from baseline to 36-month follow-up. Results indicate that reunification has no direct effect on behavioral outcomes, but is associated with increased risks in the family context of children who are reunified. Findings highlight the complex nature of the relationship between reunification and behavioral outcomes, as well as the need for reunification interventions that specifically target parental mental health and children's internalizing behaviors. Reunification research using longitudinal data and qualitative methods is recommended to clarify risks and outcomes across time. [Copyright 2007 Elsevier B.V.] JF - Children and Youth Services Review AU - Bellamy, Jennifer L AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130-4899 jbellamy@wustl.edu Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 216 EP - 228 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 30 IS - 2 SN - 0190-7409, 0190-7409 KW - Foster care Reunification Behavior problems Multiple imputation Propensity score matching KW - Family Relations KW - Child Welfare Services KW - Behavior Problems KW - Foster Care KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61426850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Children+and+Youth+Services+Review&rft.atitle=Behavioral+problems+following+reunification+of+children+in+long-term+foster+care&rft.au=Bellamy%2C+Jennifer+L&rft.aulast=Bellamy&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=30&rft.issue=2&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Children+and+Youth+Services+Review&rft.issn=01907409&rft_id=info:doi/10.1016%2Fj.childyouth.2007.09.008 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-10-02 N1 - Number of references - 40 N1 - Last updated - 2016-09-28 N1 - CODEN - CYSRDU N1 - SubjectsTermNotLitGenreText - Foster Care; Family Relations; Behavior Problems; Child Welfare Services DO - http://dx.doi.org/10.1016/j.childyouth.2007.09.008 ER - TY - BOOK T1 - Expanding Our Understanding of the Psychosocial Work Environment AN - 58769887; 2008-150285 AB - There is broad recognition that the psychosocial environment at work can affect physical and mental health as well as organizational outcomes such as work performance and effectiveness. This has been the focus of publications, recommendations and conferences developed by the NORA Organization of Work Team ). Past research across several disciplines has revealed that gender- and race-related factors such as values, biases, harassment, discrimination, and lack of support for work-family balance can affect physical and mental health. However, these features of the work environment have rarely been included simultaneously with the study of other workplace conditions. Thus, knowledge is still very limited about correlations among them, as well as about potential confounding and interactions. This document is targeted to occupational safety and health researchers interested in evaluating the role of discrimination, bias and work-family issues in occupational injuries and illness. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Feb 2008, 260 pp. AU - Bond, Meg A AU - Cazeca, Dianne AU - Daniel, Sivan AU - Kalaja, Alketa AU - Markkanen, Pia AU - Punnet, Laura AU - Tsurikova, Lana Y1 - 2008/02// PY - 2008 DA - February 2008 EP - 260p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Work and labor KW - Social conditions and policy - Psychology KW - Business and service sector - Personnel management KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Social conditions and policy - Public safety and security KW - Psychology KW - Safety measures KW - Work KW - Performance KW - Occupations KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58769887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bond%2C+Meg+A%3BCazeca%2C+Dianne%3BDaniel%2C+Sivan%3BKalaja%2C+Alketa%3BMarkkanen%2C+Pia%3BPunnet%2C+Laura%3BTsurikova%2C+Lana&rft.aulast=Bond&rft.aufirst=Meg&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=260p&rft.isbn=&rft.btitle=Expanding+Our+Understanding+of+the+Psychosocial+Work+Environment&rft.title=Expanding+Our+Understanding+of+the+Psychosocial+Work+Environment&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-104/pdfs/2008-104.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-108 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Miners' Views About Personal Dust Monitors AN - 58768083; 2008-150284 AB - Coal workers' pneumoconiosis is the leading cause of death due to occupational illness among U.S. coal miners. This disease is caused by miners' exposure to excessive levels of respirable coal mine dust. A personal dust monitor (PDM) has recently been developed to provide near real-time feedback to miners regarding the level of respirable coal dust in the air they breathe. The main objective of this report is to document coal miners' reactions to this device and how they make use of the information it provides. It summarizes a field study by the National Institute for Occupational Safety and Health that documented the opinions of 30 miners at 4 underground coal mines concerning the use of PDMs. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Feb 2008, 53 pp. AU - Hall, Erica E AU - Peters, Robert H AU - Vaught, Charles AU - Volkwein, Jon C Y1 - 2008/02// PY - 2008 DA - February 2008 EP - 53p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Health conditions and policy - Diseases and disorders KW - Social conditions and policy - Public safety and security KW - United States KW - Miners KW - Safety measures KW - Lung diseases KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58768083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hall%2C+Erica+E%3BPeters%2C+Robert+H%3BVaught%2C+Charles%3BVolkwein%2C+Jon+C&rft.aulast=Hall&rft.aufirst=Erica&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=53p&rft.isbn=&rft.btitle=Miners%27+Views+About+Personal+Dust+Monitors&rft.title=Miners%27+Views+About+Personal+Dust+Monitors&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2008-110.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-110 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Public Mental Health: The Role of Population-Based and Macrosystems Interventions in the Wake of Hurricane Katrina AN - 57287897; 200915973 AB - Policy makers and decision makers are struggling to recognize the needs of shattered communities in the wake of unimaginable devastation. Professional psychology is providing some of the answers as it examines the consequences of disaster. The authors, 6 U.S. Public Health Service commissioned officers, describe their experiences in this new arena. Working at the federal, state, and local levels of government during the national response to the Hurricane Katrina disaster, the authors strive to identify high-value practice areas and define new roles for professional psychologists. The authors suggest that traditional crisis and trauma interventions are expanding to include nontraditional population-based and macrosystems-level interventions. Such roles are explored in narrative form, providing professional and personal insight into the impact that psychologists can have on decision makers who recognize their value and position them effectively. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - McGuinness, Kevin M AU - Coady, Jeff A AU - Perez, Jon T AU - Williams, N Chanell AU - McIntyre, David J AU - Schreiber, Merritt D AD - Health Resources and Services Administration kmcguinness@hrsa.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 58 EP - 65 PB - American Psychological Association, Washington DC VL - 39 IS - 1 SN - 0735-7028, 0735-7028 KW - population-based macrosystems Katrina USNS Mercy systemic KW - Crisis intervention KW - Hurricanes KW - Public health policy KW - Psychologists KW - Policy making KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Public+Mental+Health%3A+The+Role+of+Population-Based+and+Macrosystems+Interventions+in+the+Wake+of+Hurricane+Katrina&rft.au=McGuinness%2C+Kevin+M%3BCoady%2C+Jeff+A%3BPerez%2C+Jon+T%3BWilliams%2C+N+Chanell%3BMcIntyre%2C+David+J%3BSchreiber%2C+Merritt+D&rft.aulast=McGuinness&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=39&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2F0735-7028.39.1.58 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hurricanes; Crisis intervention; Psychologists; Work roles; Public health policy; Policy making DO - http://dx.doi.org/10.1037/0735-7028.39.1.58 ER - TY - JOUR T1 - Modeling and prediction of ventilation methane emissions of U.S. longwall mines using supervised artificial neural networks AN - 50131426; 2009-098710 AB - Methane emissions from a longwall ventilation system are an important indicator of how much methane a particular mine is producing and how much air should be provided to keep the methane levels under statutory limits. Knowing the amount of ventilation methane emission is also important for environmental considerations and for identifying opportunities to capture and utilize the methane for energy production. Prediction of methane emissions before mining is difficult since it depends on a number of geological, geographical, and operational factors. This study proposes a principle component analysis (PCA) and artificial neural network (ANN)-based approach to predict the ventilation methane emission rates of U.S. longwall mines. Ventilation emission data obtained from 63 longwall mines in 10 states for the years between 1985 and 2005 were combined with corresponding coalbed properties, geographical information, and longwall operation parameters. The compiled database resulted in 17 parameters that potentially impacted emissions. PCA was used to determine those variables that most influenced ventilation emissions and were considered for further predictive modeling using ANN. Different combinations of variables in the data set and network structures were used for network training and testing to achieve minimum mean square errors and high correlations between measurements and predictions. The resultant ANN model using nine main input variables was superior to multilinear and second-order non-linear models for predicting the new data. The ANN model predicted methane emissions with high accuracy. It is concluded that the model can be used as a predictive tool since it includes those factors that influence longwall ventilation emission rates. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 371 EP - 387 PB - Elsevier, Amsterdam VL - 73 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - mines KW - numerical models KW - geologic hazards KW - underground mining KW - principal components analysis KW - natural gas KW - statistical analysis KW - coal mines KW - prediction KW - petroleum KW - coal seams KW - ventilation KW - safety KW - longwall mining KW - mathematical methods KW - coalbed methane KW - neural networks KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50131426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Modeling+and+prediction+of+ventilation+methane+emissions+of+U.S.+longwall+mines+using+supervised+artificial+neural+networks&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2008-02-01&rft.volume=73&rft.issue=3-4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.09.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal mines; coal seams; coalbed methane; geologic hazards; longwall mining; mathematical methods; mines; mining; natural gas; neural networks; numerical models; petroleum; prediction; principal components analysis; safety; statistical analysis; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2007.09.003 ER - TY - JOUR T1 - Clinically relevant end points and new drug approvals for myeloma AN - 220572053; 17972944 AB - This manuscript summarizes the recommendations of the American Society of Hematology/US Food and Drug Administration Workshop on Clinical Endpoints in Multiple Myeloma, which brought together clinical investigators in multiple myeloma, the United States Food and Drug Administration, pharmaceutical companies, patient advocates and other concerned scientists and physicians to provide guidance, consensus and consistency in the definition of clinically relevant end points to expedite new drug approvals for multiple myeloma in the appropriate trial design settings. This manuscript will therefore be a most valuable resource to provide the framework for the design of appropriate clinical trial strategies for more rapid new drug approval in myeloma. JF - Leukemia AU - Rajkumar, S V AU - Stewart, A K AU - Weber, D AU - Richardson, P Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 231 EP - 9 CY - London PB - Nature Publishing Group VL - 22 IS - 2 SN - 08876924 KW - Medical Sciences--Oncology KW - United States KW - Humans KW - United States Food & Drug Administration KW - Treatment Outcome KW - Clinical Trials as Topic KW - Drug Approval -- methods KW - Endpoint Determination KW - Multiple Myeloma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220572053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Clinically+relevant+end+points+and+new+drug+approvals+for+myeloma&rft.au=Rajkumar%2C+S+V%3BStewart%2C+A+K%3BWeber%2C+D%3BRichardson%2C+P&rft.aulast=Rajkumar&rft.aufirst=S&rft.date=2008-02-01&rft.volume=22&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fsj.leu.2405016 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Feb 2008 N1 - Last updated - 2014-03-18 DO - http://dx.doi.org/10.1038/sj.leu.2405016 ER - TY - JOUR T1 - Prevalence and characterization of Salmonella enterica serovar Weltevreden from imported seafood AN - 21055330; 8253725 AB - During 2001-2005, 210 Salmonella enterica strains were isolated from seafood samples imported into US. Strains of S. enterica serovar Weltevreden were the most predominantly found among the 64 different serovars isolated. A total of 37 Salmonella Weltevreden isolates were characterized by pulsed-field gel electrophoresis (PFGE), plasmid profiles and antibiotic susceptibility to assess genetic diversity. Our results showed a low frequency of antibiotic resistance; 35 of the 37 isolates were sensitive to ampicillin, tetracycline, chloramphenicol, gentamicin, sulfisoxazole, streptomycin and kanamycin. Only two isolates, from samples originating in the Philippines and India, showed resistance to ampicillin and tetracycline and to streptomycin, sulfisoxazole and tetracycline, respectively. Of the 37 isolates, two isolates did not carry any plasmid and 35 isolates harbored several small and mega-plasmids. These isolates were differentiated into 10 distinct types based on plasmid profiles. Four different PFGE clusters were obtained with a genetic similarity of 66-76%. Four groups of isolates (formed by two or three isolates each) showed 100% similarity in the PFGE profiles. One of these groups included strains isolated in Vietnam in 2003, 2004 and 2005 from fish and shrimp. The other groups included strains isolated in Vietnam, Indonesia and Thailand in 2000, 2004 and 2005 from snail, shrimp and fish. Our findings show genetic diversity and temporal persistence of S. enterica serovar Weltevreden in recently monitored seafood imports. JF - Food Microbiology AU - Ponce, E AU - Khan, A A AU - Cheng, C-M AU - Summage-West, C AU - Cerniglia, CE AD - Departamento de Biotecnologia Marina, Km. 107 carretera Tijuana-Ensenada, Ensenada, B.C. 22860, Mexico, ashraf.khan@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 29 EP - 35 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - Crabs KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Philippines KW - International trade KW - Thailand KW - antibiotic resistance KW - Quality assurance KW - Indonesia KW - Disease control KW - Genetic diversity KW - Sulfisoxazole KW - Kanamycin KW - Antibiotics KW - Streptomycin KW - Tetracyclines KW - India KW - Vietnam KW - Public health KW - Seafood KW - Antibiotic resistance KW - Chloramphenicol KW - Electrophoresis KW - Decapoda KW - Ampicillin KW - genetic diversity KW - Food contamination KW - Plasmids KW - Salmonella weltevreden KW - imports KW - Gentamicin KW - Salmonella enterica KW - Pulsed-field gel electrophoresis KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21055330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Prevalence+and+characterization+of+Salmonella+enterica+serovar+Weltevreden+from+imported+seafood&rft.au=Ponce%2C+E%3BKhan%2C+A+A%3BCheng%2C+C-M%3BSummage-West%2C+C%3BCerniglia%2C+CE&rft.aulast=Ponce&rft.aufirst=E&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Quality assurance; Disease control; Antibiotics; Seafood; Plasmids; Public health; Chloramphenicol; Sulfisoxazole; Ampicillin; Genetic diversity; Kanamycin; Streptomycin; Tetracyclines; Gentamicin; Pulsed-field gel electrophoresis; Antibiotic resistance; Electrophoresis; International trade; antibiotic resistance; genetic diversity; Food contamination; imports; Decapoda; Salmonella enterica; Salmonella weltevreden; Philippines; Thailand; Indonesia; Vietnam; India DO - http://dx.doi.org/10.1016/j.fm.2007.09.001 ER - TY - JOUR T1 - Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates AN - 21019136; 8037507 AB - A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10 super(7) CFU of Listeria monocytogenes results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 10 super(2) to 10 super(10) CFU of L. monocytogenes had stillbirths. A log-logistic model predicts a dose affecting 50% of animals at 10 super(7) CFU, comparable to an estimated 10 super(6) CFU based on an outbreak among pregnant women but much less than the extrapolated estimate (10 super(13) CFU) from the FDA-U.S. Department of Agriculture-CDC risk assessment using an exponential curve based on mouse data. Exposure and etiology of the disease are the same in humans and primates but not in mice. This information will aid in risk assessment, assist policy makers, and provide a model for mechanistic studies of L. monocytogenes-induced stillbirths. JF - Infection and Immunity AU - Smith, Mary Alice AU - Takeuchi, Kazue AU - Anderson, Gary AU - Ware, Glenn O AU - McClure, Harold M AU - Raybourne, Richard B AU - Mytle, Nutan AU - Doyle, Michael P AD - Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602. Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223. Experimental Statistics, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia 30602. Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322. U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 726 EP - 731 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 2 SN - 0019-9567, 0019-9567 KW - Rhesus macaque KW - Rhesus monkey KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Risk assessment KW - Listeria monocytogenes KW - Etiology KW - Data processing KW - Colony-forming cells KW - Animal models KW - Macaca mulatta KW - Primates KW - Pregnancy KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21019136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Dose-Response+Model+for+Listeria+monocytogenes-Induced+Stillbirths+in+Nonhuman+Primates&rft.au=Smith%2C+Mary+Alice%3BTakeuchi%2C+Kazue%3BAnderson%2C+Gary%3BWare%2C+Glenn+O%3BMcClure%2C+Harold+M%3BRaybourne%2C+Richard+B%3BMytle%2C+Nutan%3BDoyle%2C+Michael+P&rft.aulast=Smith&rft.aufirst=Mary&rft.date=2008-02-01&rft.volume=76&rft.issue=2&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Etiology; Data processing; Colony-forming cells; Animal models; Pregnancy; Listeria monocytogenes; Macaca mulatta; Primates ER - TY - JOUR T1 - Comparison of Seven Techniques for Typing International Epidemic Strains of Clostridium difficile: Restriction Endonuclease Analysis, Pulsed-Field Gel Electrophoresis, PCR-Ribotyping, Multilocus Sequence Typing, Multilocus Variable-Number Tandem-Repeat Analysis, Amplified Fragment Length Polymorphism, and Surface Layer Protein A Gene Sequence Typing AN - 20930698; 8039120 AB - Using 42 isolates contributed by laboratories in Canada, The Netherlands, the United Kingdom, and the United States, we compared the results of analyses done with seven Clostridium difficile typing techniques: multilocus variable-number tandem-repeat analysis (MLVA), amplified fragment length polymorphism (AFLP), surface layer protein A gene sequence typing (slpAST), PCR-ribotyping, restriction endonuclease analysis (REA), multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). We assessed the discriminating ability and typeability of each technique as well as the agreement among techniques in grouping isolates by allele profile A (AP-A) through AP-F, which are defined by toxinotype, the presence of the binary toxin gene, and deletion in the tcdC gene. We found that all isolates were typeable by all techniques and that discrimination index scores for the techniques tested ranged from 0.964 to 0.631 in the following order: MLVA, REA, PFGE, slpAST, PCR-ribotyping, MLST, and AFLP. All the techniques were able to distinguish the current epidemic strain of C. difficile (BI/027/NAP1) from other strains. All of the techniques showed multiple types for AP-A (toxinotype 0, binary toxin negative, and no tcdC gene deletion). REA, slpAST, MLST, and PCR-ribotyping all included AP-B (toxinotype III, binary toxin positive, and an 18-bp deletion in tcdC) in a single group that excluded other APs. PFGE, AFLP, and MLVA grouped two, one, and two different non-AP-B isolates, respectively, with their AP-B isolates. All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks. JF - Journal of Clinical Microbiology AU - Killgore, George AU - Thompson, Angela AU - Johnson, Stuart AU - Brazier, Jon AU - Kuijper, Ed AU - Pepin, Jacques AU - Frost, Eric H AU - Savelkoul, Paul AU - Nicholson, Brad AU - van den Berg, Renate J AU - Kato, Haru AU - Sambol, Susan P AU - Zukowski, Walter AU - Woods, Christopher AU - Limbago, Brandi AU - Gerding, Dale N AU - McDonald, LClifford AD - Centers for Disease Control and Prevention, Atlanta, Georgia. Hines VA Hospital, Hines, Illinois. Anarobe Reference Laboratory, National Public Health Service for Wales, Microbiology Cardiff University Hospital of Wales, Cardiff, United Kingdom. Department of Medical Microbiology, Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina. Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo, Japan. Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 431 EP - 437 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 2 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Amplified fragment length polymorphism KW - Gene deletion KW - Typing KW - Epidemics KW - Nucleotide sequence KW - Pulsed-field gel electrophoresis KW - Clostridium difficile KW - Endonuclease KW - Toxins KW - multilocus sequence typing KW - G 07880:Human Genetics KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20930698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Comparison+of+Seven+Techniques+for+Typing+International+Epidemic+Strains+of+Clostridium+difficile%3A+Restriction+Endonuclease+Analysis%2C+Pulsed-Field+Gel+Electrophoresis%2C+PCR-Ribotyping%2C+Multilocus+Sequence+Typing%2C+Multilocus+Variable-Number+Tandem-Repeat+Analysis%2C+Amplified+Fragment+Length+Polymorphism%2C+and+Surface+Layer+Protein+A+Gene+Sequence+Typing&rft.au=Killgore%2C+George%3BThompson%2C+Angela%3BJohnson%2C+Stuart%3BBrazier%2C+Jon%3BKuijper%2C+Ed%3BPepin%2C+Jacques%3BFrost%2C+Eric+H%3BSavelkoul%2C+Paul%3BNicholson%2C+Brad%3Bvan+den+Berg%2C+Renate+J%3BKato%2C+Haru%3BSambol%2C+Susan+P%3BZukowski%2C+Walter%3BWoods%2C+Christopher%3BLimbago%2C+Brandi%3BGerding%2C+Dale+N%3BMcDonald%2C+LClifford&rft.aulast=Killgore&rft.aufirst=George&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene deletion; Amplified fragment length polymorphism; Epidemics; Typing; Nucleotide sequence; Pulsed-field gel electrophoresis; Endonuclease; Toxins; multilocus sequence typing; Clostridium difficile ER - TY - JOUR T1 - ACUT2E TSE-SSFP: A hybrid method for T2-weighted imaging of edema in the heart AN - 20859374; 8368686 AB - ACUT2E TSE-SSFP is a hybrid between steady state free precession (SSFP) and turbo spin echo (TSE) for bright-blood T2-weighted imaging with signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) similar to dark-blood TSE. TSE-SSFP uses a segmented SSFP readout during diastole with 180DG pulses following a 90DG preparation. The 180DG refocusing pulses make TSE-SSFP similar to TSE but TSE-SSFP uses gradient moment nulling, whereas TSE uses gradient crushing. TSE-SSFP produced T2-weighted images with minimal T1 weighting. TSE-SSFP and TSE had similar SNR (155.9 - 6.0 vs 160.9 - 7.0; P = NS) for acute myocardial infarction (MI) and twice the SNR of T2-prepared SSFP (73.1 - 3.4, P < 0.001). TSE-SSFP and TSE had approximately double the CNR of T2-prepared SSFP for differentiating acute MI from normal myocardium. Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP. Magn Reson Med 59:229-235, 2008. JF - Magnetic Resonance in Medicine AU - Aletras, Anthony H AU - Kellman, Peter AU - Derbyshire, J Andrew AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, aletrasa@nhlbi.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 229 EP - 235 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Blood KW - Hybrids KW - Edema KW - N.M.R. KW - imaging KW - Myocardial infarction KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=ACUT2E+TSE-SSFP%3A+A+hybrid+method+for+T2-weighted+imaging+of+edema+in+the+heart&rft.au=Aletras%2C+Anthony+H%3BKellman%2C+Peter%3BDerbyshire%2C+J+Andrew%3BArai%2C+Andrew+E&rft.aulast=Aletras&rft.aufirst=Anthony&rft.date=2008-02-01&rft.volume=59&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21490 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Hybrids; N.M.R.; Blood; Myocardium; Myocardial infarction; Heart; Edema DO - http://dx.doi.org/10.1002/mrm.21490 ER - TY - JOUR T1 - Infectious Disease Hospitalizations Among Infants in the United States AN - 20844401; 8041819 AB - OBJECTIVE. This study describes the burden and epidemiologic features of infectious disease hospitalizations among infants in the United States. METHODS. Hospitalizations with an infectious disease listed as a primary diagnosis for infants (1 million hospital days for infants. Infectious disease hospitalization rates were highest among boys and nonwhite infants. The most commonly listed diagnoses among the infant infectious disease hospitalizations included lower respiratory tract infections (59.0%), kidney, urinary tract, and bladder infections (7.6%), upper respiratory tract infections (6.5%), and septicemia (6.5%). The median cost of an infectious disease hospitalization was $2235, with total annual hospital costs of approximately $690 million, among infants in the United States. CONCLUSIONS. Infectious disease hospitalizations among infants account for substantial health care expenditures and hospital time in the United States, with respiratory disease hospitalizations constituting more than one half of all hospitalizations. Younger infants, boys, and nonwhite infants were at increased risk for infectious disease hospitalization. Measures to reduce racial disparities and the occurrence of respiratory tract infections should substantially decrease the infectious disease burden among infants. JF - Pediatrics AU - Yorita, Krista L AU - Holman, Robert C AU - Sejvar, James J AU - Steiner, Claudia A AU - Schonberger, Lawrence B AD - Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Healthcare Cost and Utilization Project, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 244 EP - 252 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 2 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts B: Bacteriology KW - Respiratory tract diseases KW - Databases KW - Age KW - Infectious diseases KW - Septicemia KW - Urinary bladder KW - Kidney KW - Urinary tract KW - Infection KW - Infants KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Infectious+Disease+Hospitalizations+Among+Infants+in+the+United+States&rft.au=Yorita%2C+Krista+L%3BHolman%2C+Robert+C%3BSejvar%2C+James+J%3BSteiner%2C+Claudia+A%3BSchonberger%2C+Lawrence+B&rft.aulast=Yorita&rft.aufirst=Krista&rft.date=2008-02-01&rft.volume=121&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Respiratory tract diseases; Age; Septicemia; Infectious diseases; Urinary bladder; Kidney; Urinary tract; Infection; Hospitals; Infants ER - TY - JOUR T1 - Mathematical treatment of plates with colony counts outside the acceptable range AN - 20779855; 8253732 AB - The exclusion of plate counts outside of an acceptable range can bias the estimation of concentration. If these plates are too numerous to count (TNTC), then their microbes may be inhibited. If inhibition of the microbes on a plate is suspected, then its count may be best treated as a lower bound. When these lower bounds replace counts for some plates, the estimate and confidence interval must be calculated accordingly. Also, a measure of unusualness for plate counts is discussed. JF - Food Microbiology AU - Blodgett, R J AD - Food and Drug Administration, Room 2D-011, HFS-012, 5100 Paint Branch Parkway, College Park, MD 20740, USA, robert.blodgett@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 92 EP - 98 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Colonies KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20779855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Mathematical+treatment+of+plates+with+colony+counts+outside+the+acceptable+range&rft.au=Blodgett%2C+R+J&rft.aulast=Blodgett&rft.aufirst=R&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonies DO - http://dx.doi.org/10.1016/j.fm.2007.07.006 ER - TY - JOUR T1 - The public health approach to occupational injury research: From surveillance to prevention AN - 20653806; 8099868 AB - The National Institute for Occupational Safety and Health (NIOSH) in the US uses the public health model as the framework for occupational injury prevention research. This model is described, along with where we have made progress in this research process, and where we need to focus our efforts in the future. The specific role of surveillance in research and prevention of occupational injuries is also discussed, as well as the importance of partnership efforts to facilitate the transfer of research to practice. Suggestions are provided for stimulating a global approach to surveillance and to the transfer of research to practice. JF - Safety Science AU - Stout, NA AD - National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA, nas5@cdc.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 230 EP - 233 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 46 IS - 2 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Injuries KW - Occupational safety KW - prevention KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20653806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=The+public+health+approach+to+occupational+injury+research%3A+From+surveillance+to+prevention&rft.au=Stout%2C+NA&rft.aulast=Stout&rft.aufirst=NA&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2007.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; prevention; Injuries DO - http://dx.doi.org/10.1016/j.ssci.2007.04.009 ER - TY - JOUR T1 - Isolation and Characterization of Vibrio tubiashii Outer Membrane Proteins and Determination of a toxR Homolog AN - 20622775; 8032753 AB - Outer membrane proteins (OMPs) expressed by Vibrio tubiashii under different environmental growth conditions were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and PCR analyses. Results showed the presence of a 38- to 40-kDa OmpU-like protein and ompU gene, a maltoporin-like protein, several novel OMPs, and a regulatory toxR homolog. JF - Applied and Environmental Microbiology AU - Beaubrun, JJean-Gilles AU - Kothary, M H AU - Curtis, S K AU - Flores, N C AU - Eribo, B E AU - Tall, B D AD - Howard University, Washington, D.C. 20050. U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 907 EP - 911 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 3 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - outer membrane proteins KW - Amino acids KW - Growth conditions KW - Nucleotide sequence KW - Vibrio tubiashii KW - Gel electrophoresis KW - Biological membranes KW - OmpU protein KW - Microorganisms KW - DNA KW - Polymerase chain reaction KW - Proteins KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20622775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Isolation+and+Characterization+of+Vibrio+tubiashii+Outer+Membrane+Proteins+and+Determination+of+a+toxR+Homolog&rft.au=Beaubrun%2C+JJean-Gilles%3BKothary%2C+M+H%3BCurtis%2C+S+K%3BFlores%2C+N+C%3BEribo%2C+B+E%3BTall%2C+B+D&rft.aulast=Beaubrun&rft.aufirst=JJean-Gilles&rft.date=2008-02-01&rft.volume=74&rft.issue=3&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Amino acids; Nucleotide sequence; DNA; Microorganisms; Proteins; Polymerase chain reaction; Biological membranes; outer membrane proteins; Growth conditions; OmpU protein; Gel electrophoresis; Vibrio tubiashii ER - TY - JOUR T1 - Low-Level Neonatal Thimerosal Exposure: Further Evaluation of Altered Neurotoxic Potential in SJL Mice AN - 20566983; 8043208 AB - Ethylmercury in thimerosal-preserved childhood vaccines has been suggested to be neurotoxic and to contribute to the etiology of neurodevelopmental disorders, including autism. Immune system function may be an important factor influencing vulnerability of the developing nervous system to thimerosal. This possibility is based in part on a report by Hornig et al. (2004, Mol. Psychiatry 9, 833-845) of neurodevelomental toxicity in SJL/J mice that develop autoantibodies when exposed to organic mercury. The present study reexamined this possibility by injecting neonatal SJL/J mice with thimerosal, with and without combined HiB and DTP vaccines. Injections modeled childhood vaccination schedules, with mice injected on postnatal days 7, 9, 11, and 15 with 14.2, 10.8, 9.2, and 5.6 mu g/kg mercury from thimerosal, respectively, or vehicle. Additional groups received vaccine only or a 10 times higher thimerosal + vaccine dose. Low levels of mercury were found in blood, brain, and kidneys 24 h following the last thimerosal injection. Survival, body weight, indices of early development (negative geotaxis, righting) and hippocampal morphology were not affected. Performance was unaffected in behavioral tests selected to assess behavioral domains relevant to core deficits in neurodevelopmental disorders such as autism (i.e., social interaction, sensory gating, anxiety). In an open-field test the majority of behaviors were unaffected by thimerosal injection, although thimerosal-injected female mice showed increased time in the margin of an open field at 4 weeks of age. Considered together the present results do not indicate pervasive developmental neurotoxicity following vaccine-level thimerosal injections in SJL mice, and provide little if any support for the hypothesis that thimerosal exposure contributes to the etiology of neurodevelopmental disorders. JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Isaac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, Jean AD - Department of Neurological Surgery and the Center for Children's Environmental Health. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Laboratory of Experimental Gerontology NIA/NIH, Baltimore, Maryland 21224. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 294 EP - 309 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 2 SN - 1096-6080, 1096-6080 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - thimerosal KW - Neurodevelopmental disorders KW - Pertussis KW - Age KW - Anxiety KW - Hippocampus KW - Immune system KW - Survival KW - Tetanus KW - Nervous system KW - Body weight KW - Combined vaccines KW - Geotaxis KW - Etiology KW - Diphtheria KW - Children KW - Social interactions KW - Blood KW - Autoantibodies KW - Gating KW - Neurotoxicity KW - Kidney KW - Mercury KW - Vaccines KW - Neonates KW - Autism KW - Psychiatry KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20566983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Low-Level+Neonatal+Thimerosal+Exposure%3A+Further+Evaluation+of+Altered+Neurotoxic+Potential+in+SJL+Mice&rft.au=Berman%2C+Robert+F%3BPessah%2C+Isaac+N%3BMouton%2C+Peter+R%3BMav%2C+Deepak%3BHarry%2C+Jean&rft.aulast=Berman&rft.aufirst=Robert&rft.date=2008-02-01&rft.volume=101&rft.issue=2&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; thimerosal; Pertussis; Age; Anxiety; Hippocampus; Immune system; Survival; Tetanus; Nervous system; Body weight; Combined vaccines; Geotaxis; Etiology; Diphtheria; Children; Social interactions; Blood; Autoantibodies; Gating; Neurotoxicity; Kidney; Mercury; Neonates; Vaccines; Psychiatry; Autism ER - TY - JOUR T1 - Risk Factors for Pediatric Invasive Pneumococcal Disease in the Intermountain West, 1996-2002 AN - 20561257; 9272816 AB - Purpose In response to concerns that the epidemiology of pediatric invasive pneumococcal disease (IPD) in the Intermountain West (i.e., Utah, Idaho, Wyoming, Montana, and parts of Arizona and Nevada) was poorly understood and might differ from elsewhere in the United States, a case-control study was undertaken to determine factors associated with IPD during 1996-2002. Methods A telephone questionnaire was administered to parents of children comprising 120 cases identified through hospital records and to parents of 156 age-matched controls located by random-digit dialing. The unit of analysis was each matched case-control set. Results Underlying chronic illness was reported for 32 (27%) of the cases. For previously healthy children, breastfeeding had a protective benefit (adjusted odds ratio: 0.2; 95% confidence interval [CI], 0.1-0.6), while a history of tympanostomy tube surgery was a risk factor (adjusted odds ratio: 12.6; 95% CI, 1.5-107.3). Conclusions The presence of an underlying chronic illness was the strongest risk factor for IPD. Except for a history of tympanostomy tube surgery, the factors associated with IPD in this investigation were similar to those reported from other geographic regions. Tympanostomy surgery might serve as a surrogate indicator for predisposition to recurrent otitis media or decreased ability to clear pneumococcal infection, raising risk for invasive disease. Pediatric clinicians should continue to encourage breastfeeding, and continued emphasis on pneumococcal vaccination should help prevent IPD. Key Words: Children; Streptococcus pneumoniae; Immunization; Utah Abbreviations: CI, confidence interval; Hib, Haemophilus influenzae type b; IPD, invasive pneumococcal disease; OR, odds ratio; PCV-7, 7-valent pneumococcal conjugate vaccine JF - Annals of Epidemiology AU - Haddad, Maryam B AU - Fnp AU - Porucznik, Christina A AU - Msph AU - Joyce, Kerry E AU - De, Anindya K AU - Pavia, Andrew T AU - Rolfs, Robert T AU - Byington, Carrie L AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, maryam.haddad@cdc.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 139 EP - 146 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 2 SN - 1047-2797, 1047-2797 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - breast feeding KW - Historical account KW - vaccines KW - USA, Nevada KW - surgery KW - immunization KW - Surgery KW - Risk factors KW - infection KW - Breast feeding KW - Recurrent infection KW - USA, Montana KW - USA, Utah KW - Inventories KW - USA, Wyoming KW - Haemophilus influenzae KW - Pediatrics KW - USA, Utah, Intermountain West KW - Children KW - Vaccination KW - USA, Idaho KW - Streptococcus pneumoniae KW - Epidemiology KW - Otitis media KW - USA, Arizona KW - Vaccines KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk+Factors+for+Pediatric+Invasive+Pneumococcal+Disease+in+the+Intermountain+West%2C+1996-2002&rft.au=Haddad%2C+Maryam+B%3BFnp%3BPorucznik%2C+Christina+A%3BMsph%3BJoyce%2C+Kerry+E%3BDe%2C+Anindya+K%3BPavia%2C+Andrew+T%3BRolfs%2C+Robert+T%3BByington%2C+Carrie+L&rft.aulast=Haddad&rft.aufirst=Maryam&rft.date=2008-02-01&rft.volume=18&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inventories; Epidemiology; Pediatrics; Otitis media; Risk factors; Surgery; Recurrent infection; Breast feeding; Vaccines; Children; Vaccination; Hospitals; immunization; breast feeding; Historical account; vaccines; infection; surgery; Streptococcus pneumoniae; Haemophilus influenzae; USA, Utah; USA, Idaho; USA, Wyoming; USA, Arizona; USA, Utah, Intermountain West; USA, Nevada; USA, Montana DO - http://dx.doi.org/10.1016/j.annepidem.2007.09.006 ER - TY - JOUR T1 - Structure-activity relationship analysis tools: Validation and applicability in predicting carcinogens AN - 20538720; 8090513 AB - OncoLogic super(()R) and MultiCASE (MCASE) are two structure-activity relationship (SAR) analysis software programs available to screen compounds for potential carcinogenicity. Ashby-Tennant structural alerts [Ashby, J., Tennant, R.W., 1991. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257, 229-306] and genetic toxicity testing may also be used to assess/predict this endpoint. Six-hundred and fifty compounds tested for carcinogenicity whose results were tabulated in the Carcinogenic Potency Database (CPDB) were used to validate and compare the predictivity of OncoLogic super(()R) (Version 4.1), MCASE (Version 3.1), Ashby-Tennant structural alerts, and genetic toxicity testing, individually and in combination. The sensitivity of the methods for predicting carcinogens and the specificity for predicting non-carcinogens was examined. Potent carcinogens, defined as those with TD sub(5) sub(0) values of less than 6.25mg/kg bw/d, were then examined separately. It is concluded that SAR analysis programs and structural alerts perform well for compounds with low human exposure levels and have the potential to supplement the results of routinely requested genetic toxicity tests in a weight-of-evidence approach in predicting carcinogenicity, although each method of analysis has limitations regarding applicability. JF - Regulatory Toxicology and Pharmacology AU - Mayer, J AU - Cheeseman, MA AU - Twaroski, M L AD - Division of Food Contact Notifications, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA, julie.mayer@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 50 EP - 58 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 0273-2300, 0273-2300 KW - Toxicology Abstracts KW - Computer programs KW - Databases KW - Mutagenicity KW - software KW - Carcinogenicity KW - Carcinogens KW - Toxicity KW - Toxicity testing KW - Structure-activity relationships KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20538720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Structure-activity+relationship+analysis+tools%3A+Validation+and+applicability+in+predicting+carcinogens&rft.au=Mayer%2C+J%3BCheeseman%2C+MA%3BTwaroski%2C+M+L&rft.aulast=Mayer&rft.aufirst=J&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Computer programs; software; Mutagenicity; Carcinogenicity; Toxicity; Carcinogens; Structure-activity relationships; Toxicity testing DO - http://dx.doi.org/10.1016/j.yrtph.2007.09.005 ER - TY - JOUR T1 - Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure AN - 20522161; 9216859 AB - Changes in the histological morphology of the caudate-putamen (CPu) were determined after a high-dose methamphetamine (METH) exposure in an effort to elucidate whether BBB disruption plays a role in CPu neurotoxicity. This was accomplished by evaluating the tyrosine hydroxylase immunoreactivity (TH-IR), isolectin B4 reactivity, Black Gold II (BG-II) and Fluoro-Jade C (FJ-C) staining, and immunoreactivity to mouse immunoglobulin G (IgG-IR) in adult male mice at 90-min, 4-h, 12-h, 1-day, and 3-day post-METH exposure. The IgG-IR indicated that the BBB was only modestly altered in the CPu at time points after neurodegeneration occurred and dependent on hyperthermia and status epilepticus. The modest CPu IgG-IR changes observed in the perivascular areas indicated that immunoglobulins were present on some CPu microglia 1 day or more after METH. The first signs of CPu damage were swellings in the TH-IR axons, myelin damage, and a few degenerating neurons at 4-h post-METH. The loss of TH-IR was dependent on hyperthermia but not seizures or CPu neurodegeneration, and the TH-IR was virtually absent throughout the CPu within 12 h. Surprisingly, signs of FJ-C labeling (degenerating) axons in the CPu were seen only in the regions of pronounced somatic neurodegeneration and independent of TH-IR loss. Microglial activation did not occur until 1 day or more post-METH. In summary, a major BBB disruption within the CPu does not directly contribute to neurotoxicity in this single high-dose METH exposure. However, seizure activity produced or exacerbated by amygdalar BBB disruption can significantly increase CPu somatic neurodegeneration (but not affect dopamine (DA) terminal damage). The time course of microglial activation indicates a response to the neurodegeneration, myelin damage, and/or damaged DA terminals after loss of TH-IR. Synapse 62:193-204, 2008. JF - Synapse AU - Bowyer, John F AU - Robinson, Bonnie AU - Ali, Syed AU - Schmued, Larry C AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, john.bowyer@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 193 EP - 204 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 62 IS - 3 SN - 0887-4476, 0887-4476 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Hyperthermia KW - Synapses KW - Myelin KW - Caudate-putamen KW - Blood-brain barrier KW - Seizures KW - Microglia KW - Neurodegeneration KW - Methamphetamine KW - Dopamine KW - Epilepsy KW - Neurotoxicity KW - Immunoreactivity KW - Immunoglobulin G KW - Gold KW - Axons KW - Tyrosine 3-monooxygenase KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse&rft.atitle=Neurotoxic-related+changes+in+tyrosine+hydroxylase%2C+microglia%2C+myelin%2C+and+the+blood-brain+barrier+in+the+caudate-putamen+from+acute+methamphetamine+exposure&rft.au=Bowyer%2C+John+F%3BRobinson%2C+Bonnie%3BAli%2C+Syed%3BSchmued%2C+Larry+C&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2008-02-01&rft.volume=62&rft.issue=3&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Synapse&rft.issn=08874476&rft_id=info:doi/10.1002%2Fsyn.20478 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Synapses; Hyperthermia; Myelin; Blood-brain barrier; Caudate-putamen; Seizures; Microglia; Neurodegeneration; Methamphetamine; Dopamine; Epilepsy; Immunoreactivity; Neurotoxicity; Immunoglobulin G; Gold; Axons; Tyrosine 3-monooxygenase DO - http://dx.doi.org/10.1002/syn.20478 ER - TY - JOUR T1 - Development of hand-arm system models for vibrating tool analysis and test rig construction AN - 20522126; 8055044 AB - The vibration and noise generated by powered hand tools may be affected by human interaction with these tools. This effect can be taken into account by including a hand-arm system model in tool analysis and testing. The objective of this study is to propose a general methodology for developing practical models for tool analyses and test rig constructions. To demonstrate the methodology, this study applied three traditional models (2-, 3-, and 4-degree-of-freedom (DOF) models) as well as a new 4-DOF model proposed by the authors. The biodynamic responses to hand-transmitted vibration measured at the hand driving-point along the forearm direction under combined grip and push actions were used to determine the parameters of the models using a least root-mean-square error curve fitting method. This study found that the new 4-DOF model and the traditional 3-DOF and 4-DOF models accurately represented the experimental mechanical impedance (MI). The transmissibility functions predicted using these models were also consistent with their corresponding experimental data measured on the fingers and at the wrist. When judged using apparent mass (AM) instead of MI, the traditional 2-DOF model also fits the experimental data well. The parameters of the 2-DOF and new 4-DOF models are more reasonable than those of the other two models for test rig construction. This study concluded that the new 4-DOF model provides the best choice for analyzing tools and for constructing test rigs. However, if the hand-tool dynamic interactions below 100 Hz are of major concern, the 2-DOF model is simpler and less expensive for test rig construction. Whereas these two models can be directly used in some applications, the proposed methodology can be used to develop a more tool-specific model when biodynamic response data for the specific tool are available. JF - Noise Control Engineering Journal AU - Dong, R G AU - Welcome, DE AU - Wu, J Z AU - McDowell, T W AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown WV 26505 USA, rkd6@cdc.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 35 EP - 44 VL - 56 IS - 1 SN - 0736-2501, 0736-2501 KW - Health & Safety Science Abstracts KW - Man-machine interactions KW - Working conditions KW - Vibration KW - hand tools KW - Occupational exposure KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=Development+of+hand-arm+system+models+for+vibrating+tool+analysis+and+test+rig+construction&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BWu%2C+J+Z%3BMcDowell%2C+T+W&rft.aulast=Dong&rft.aufirst=R&rft.date=2008-02-01&rft.volume=56&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vibration; Ergonomics; Man-machine interactions; Occupational exposure; Working conditions; hand tools ER - TY - JOUR T1 - Prevalence of allergic sensitization to indoor fungi in West Virginia AN - 20214251; 10147346 AB - Exposure to indoor fungi is of growing concern in residential and occupational environments in the United States. The purpose of this study was to determine the prevalence of sensitization to common indoor fungal species in an atopic population. We evaluated 102 patients (73 female and 29 male patients) for immunoglobulin E (IgE) reactivity to a panel of skin-prick test (SPT) reagents used for routine allergy testing. Patients also were tested for six additional fungi that are common indoor contaminants. All patients had symptoms consistent with allergic rhinitis or asthma. The presence of specific IgE against the fungal species was determined using immunoblotting. Of the 102 eligible patients, 68% had at least one positive skin test. The most prevalent positive SPTs were to dust mites, cats, vernal grass, and short ragweed. Overall, 21/102 (21%) patients with asthma or allergic rhinitis were skin test positive to at least one fungal extract. Of the patients with a positive SPT to fungi, 12/21 (58%) showed sensitivity to one or more of the newly tested species; most notably Trichoderma viride (8%), Chaetomium globosum (7%), Paecilomyces variotii (7%), and Acremonium strictum (6%). Immunoblotting revealed specific IgE against a number of protein bands belonging to these fungal species. The prevalence of fungal sensitization was common, particularly for indoor fungal contaminants that are not routinely included in SPT panels. Cross-reactivity with other fungi may partially explain our results; however, skin testing for these indoor fungi may provide useful diagnostic information. JF - Allergy and Asthma Proceedings AU - Beezhold, Donald H AU - Green, Brett J AU - Blachere, Francoise M AU - Schmechel, Detlef AU - Weissman, David N AU - Velickoff, Deborah AU - Hogan, Mary Beth AU - Wilson, Nevin W AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 29 EP - 34 PB - OceanSide Publications, Inc. VL - 29 IS - 1 SN - 1088-5412, 1088-5412 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - K 03410:Animal Diseases KW - F 06925:Hypersensitivity KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20214251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Allergy+and+Asthma+Proceedings&rft.atitle=Prevalence+of+allergic+sensitization+to+indoor+fungi+in+West+Virginia&rft.au=Beezhold%2C+Donald+H%3BGreen%2C+Brett+J%3BBlachere%2C+Francoise+M%3BSchmechel%2C+Detlef%3BWeissman%2C+David+N%3BVelickoff%2C+Deborah%3BHogan%2C+Mary+Beth%3BWilson%2C+Nevin+W&rft.aulast=Beezhold&rft.aufirst=Donald&rft.date=2008-02-01&rft.volume=29&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Allergy+and+Asthma+Proceedings&rft.issn=10885412&rft_id=info:doi/10.2500%2Faap2008.29.3076 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.2500/aap2008.29.3076 ER - TY - JOUR T1 - Prevalence and characterization of macrolide-lincomycin-streptogramin B-resistant Staphylococcus aureus in Korean hospitals AN - 20088096; 8037662 JF - Journal of Antimicrobial Chemotherapy AU - Jung, Young-Hee AU - Kim, Kwang Wook AU - Lee, Kyeong Min AU - Yoo, Jae Il AU - Chung, Gyung Tae AU - Kim, Bong Soo AU - Kwak, Hyo-Sun AU - Lee, Yeong Seon AD - Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea. Division of Biodefence Research, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea. Food Microbiology Team, Center for Food Safety Evaluation, Korea Food and Drug Administration, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-704, Republic of Korea Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 458 EP - 460 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 61 IS - 2 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Staphylococcus aureus KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20088096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Prevalence+and+characterization+of+macrolide-lincomycin-streptogramin+B-resistant+Staphylococcus+aureus+in+Korean+hospitals&rft.au=Jung%2C+Young-Hee%3BKim%2C+Kwang+Wook%3BLee%2C+Kyeong+Min%3BYoo%2C+Jae+Il%3BChung%2C+Gyung+Tae%3BKim%2C+Bong+Soo%3BKwak%2C+Hyo-Sun%3BLee%2C+Yeong+Seon&rft.aulast=Jung&rft.aufirst=Young-Hee&rft.date=2008-02-01&rft.volume=61&rft.issue=2&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells AN - 19999113; 8095807 AB - In addition to occupational exposures to acrylamide (AA), concerns about AA health risks for the general population have been recently raised due to the finding of AA in food. In this study, we evaluated the genotoxicity of AA and its metabolite glycidamide (GA) in L5178Y/Tk super(+) super(/) super(-) mouse lymphoma cells. The cells were treated with 2-18mM of AA or 0.125-4mM of GA for 4h without metabolic activation. The DNA adducts, mutant frequencies and the types of mutations for the treated cells were examined. Within the dose range tested, GA induced DNA adducts of adenine and guanine [N3-(2-carbamoyl-2-hydroxyethyl)-adenine and N7-(2-carbamoyl-2-hydroxyethyl)-guanine] in a linear dose-dependent manner. The levels of guanine adducts were consistently about 60-fold higher across the dose range than those of adenine. In contrast, no GA-derived DNA adducts were found in the cells treated with any concentrations of AA, consistent with a lack of metabolic conversion of AA to GA. However, the mutant frequency was significantly increased by AA at concentrations of 12mM and higher. GA was mutagenic starting with the 2mM dose, suggesting that GA is much more mutagenic than AA. The mutant frequencies were increased with increasing concentrations of AA and GA, mainly due to an increase of proportion of small colony mutants. To elucidate the underlying mutagenic mechanism, we examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for mutants induced by AA or GA. Compared to GA induced mutations, AA induced more mutants whose LOH extended to D11Mit22 and D11Mit74, an alteration of DNA larger than half of the chromosome. Statistical analysis of the mutational spectra revealed a significant difference between the types of mutations induced by AA and GA treatments (P=0.018). These results suggest that although both AA and GA generate mutations through a clastogenic mode of action in mouse lymphoma cells, GA induces mutations via a DNA adduct mechanism whereas AA induces mutations by a mechanism not involving the formation of GA adducts. JF - Food and Chemical Toxicology AU - Mei, N AU - Hu, J AU - Churchwell, MI AU - Guo, L AU - Moore, M M AU - Doerge AU - Chen, T AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States, nan.mei@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 628 EP - 636 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 2 SN - 0278-6915, 0278-6915 KW - Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - chromosome 11 KW - DNA adducts KW - Food KW - Genotoxicity KW - Microsatellites KW - Statistical analysis KW - Mutant frequency KW - Loss of heterozygosity KW - Chromosomes KW - Guanine KW - Colonies KW - Acrylamide KW - Adenine KW - Metabolic activation KW - Lymphoma KW - Mutation KW - Occupational exposure KW - F 06955:Immunomodulation & Immunopharmacology KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19999113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Genotoxic+effects+of+acrylamide+and+glycidamide+in+mouse+lymphoma+cells&rft.au=Mei%2C+N%3BHu%2C+J%3BChurchwell%2C+MI%3BGuo%2C+L%3BMoore%2C+M+M%3BDoerge%3BChen%2C+T&rft.aulast=Mei&rft.aufirst=N&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.09.093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA adducts; chromosome 11; Food; Genotoxicity; Statistical analysis; Microsatellites; Mutant frequency; Loss of heterozygosity; Colonies; Guanine; Chromosomes; Acrylamide; Adenine; Metabolic activation; Mutation; Lymphoma; Occupational exposure DO - http://dx.doi.org/10.1016/j.fct.2007.09.093 ER - TY - JOUR T1 - Urinary hCG patterns during the week following implantation AN - 19466249; 8037318 AB - BACKGROUND: Human chorionic gonadotrophin (hCG) is used to monitor pregnancy status. Yet the pattern of hCG excretion in the first week following implantation has not been adequately described.Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies. METHODS: We measured daily hCG concentrations in first-morning urine for 142 clinical pregnancies from women with no known fertility problems. Mixed-effects regression models were used to estimate the hCG trajectory and its variability in relation to pregnancy outcomes. RESULTS: hCG rose 3-fold between the day of detection and the next day (95% CI = 2.7-3.4). The relative rate of rise decreased thereafter, reaching 1.6-fold (95% CI = 1.5-1.8) between days 6 and 7. HCG levels followed a log-quadratic trajectory, and the patterns of rise were unrelated to number of fetuses, risk of spontaneous abortion or sex of the baby. Later implantations (after 10 luteal days) produced slower rates of increase. CONCLUSIONS: Although mean hCG follows a log-quadratic trajectory during the first week of detectability, there is high variability across pregnancies. Later implantation may reflect characteristics of the uterus or conceptus that slow hCG production. JF - Human Reproduction AU - Nepomnaschy, P A AU - Weinberg, C R AU - Wilcox, A J AU - Baird, D D AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO BOX 12233, MD A3-05, Rm 309, 111 TW Alexander Drive, Research Triangle Park, NC, USA. Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 271 EP - 277 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 2 SN - 0268-1161, 0268-1161 KW - Biotechnology and Bioengineering Abstracts KW - Fertility KW - Uterus KW - Urine KW - Abortion KW - Regression analysis KW - Excretion KW - Pituitary (anterior) KW - Fetuses KW - Pregnancy KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Urinary+hCG+patterns+during+the+week+following+implantation&rft.au=Nepomnaschy%2C+P+A%3BWeinberg%2C+C+R%3BWilcox%2C+A+J%3BBaird%2C+D+D&rft.aulast=Nepomnaschy&rft.aufirst=P&rft.date=2008-02-01&rft.volume=23&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Fertility; Urine; Abortion; Regression analysis; Excretion; Pituitary (anterior); Fetuses; Models; Pregnancy ER - TY - JOUR T1 - A new chromogenic agar medium for detection of potentially virulent Yersinia enterocolitica AN - 19298269; 8091386 AB - Several outbreaks of foodborne yersiniosis have been documented and this disease continues to be source of infections transmitted through foods. The selective agars most commonly used to isolate Yersinia enterocolitica in clinical, food and environmental samples, cefsulodin-irgasan-novobiocin (CIN) and MacConkey (MAC) agars, lack the ability to differentiate potentially virulent Y. enterocolitica from other Yersinia that may be present as well as some other bacterial spp. This study proposes the use of an agar medium, Y. enterocolitica chromogenic medium (YeCM), for isolation of potentially virulent Y. enterocolitica. This agar contains cellobiose as the fermentable sugar, a chromogenic substrate and selective inhibitors for suppression of colony formation by many competing bacteria. All strains of potentially virulent Yersinia of biotypes 1B, and biotypes 2-5 formed convex, red bulls-eye colonies on YeCM that were very similar to those described for CIN agar. However, Y. enterocolitica biotype 1A and other related Yersinia formed colonies that were purple/blue on YeCM while they formed typical red bulls-eye colonies on CIN agar. When a mixture of potentially virulent Y. enterocolitica biotype 1B, Y. enterocolitica biotype 1A and 5 other bacterial species was used to artificially contaminate tofu and then spread-plated on three selective agars, Y. enterocolitica biotype 1B colonies were easily distinguished from other strains on YeCM. However, Y. enterocolitica biotype 1B colonies were indistinguishable from many other colonies on CIN and only distinguishable from those of C. freundii on MAC. When colonies were picked and identified from these agars, typical colonies from YeCM were confirmed only as Y. enterocolitica biotype 1B. Typical colonies on CIN and MAC were found to belong to several competing species and biotypes. JF - Journal of Microbiological Methods AU - Weagant, S D AD - Pacific Regional Laboratory Northwest, Bothell, WA 98021-4421, 22201 23rd Dr. S. E., Bothell, WA 98021-4421, United States, steve.weagant@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 185 EP - 190 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 72 IS - 2 SN - 0167-7012, 0167-7012 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Environmental monitoring KW - Agar KW - Sugar KW - Biotypes KW - cellobiose KW - Food KW - outbreaks KW - Food contamination KW - Infection KW - Colonies KW - Yersiniosis KW - infection KW - Yersinia enterocolitica KW - biotypes KW - H 4000:Food and Drugs KW - W 30900:Methods KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=A+new+chromogenic+agar+medium+for+detection+of+potentially+virulent+Yersinia+enterocolitica&rft.au=Weagant%2C+S+D&rft.aulast=Weagant&rft.aufirst=S&rft.date=2008-02-01&rft.volume=72&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2007.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sugar; Agar; Colonies; Biotypes; Yersiniosis; cellobiose; Food; Infection; Environmental monitoring; infection; outbreaks; Food contamination; biotypes; Yersinia enterocolitica DO - http://dx.doi.org/10.1016/j.mimet.2007.11.019 ER - TY - JOUR T1 - The U.S. Mandatory Guidelines for Federal Workplace Drug Testing Programs: current status and future considerations. AN - 70194762; 17434274 AB - The U.S. Department of Health and Human Services (HHS) drug testing standards were published in 1988 and revised in 1994, 1998, and 2004. In 2004, significant revisions defining, standardizing, and requiring specimen validity testing on Federal employee donor urine specimens were included. In a separate notice, HHS proposed to establish scientific and technical guidelines for the Federal Workplace Drug Testing Program to: (1) permit laboratory testing of hair, oral fluid, and sweat patch specimens in addition to urine specimens for marijuana, cocaine, phencyclidine, opiates (with focus on heroin), and amphetamines [including methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDEA), methylenedioxyamphetamine (MDA)]; (2) permit use of on-site point of collection test (POCT) devices to test urine and oral fluid at collection sites; (3) permit use of instrumented initial test (screening only) facilities [IITF] to quickly identify negative specimens; and (4) add training requirement for collectors, on-site testers, and MROs. This proposal was published in the Federal Register on 13 April 2004, with a 90-day public comment period. The Substance Abuse and Mental Health Services Administration, HHS, reviewed those comments and is preparing the Final Notice that will define the requirements for such testing, including: specimen collection procedures, custody and control procedures that ensure donor specimen identity and integrity, testing facility, initial and confirmatory test cutoff concentrations, analytical testing methods, result review and reporting, evaluation of alternative medical explanations for presence of drug or metabolite in the donor's specimen, and laboratory certification issues. Voluntary pilot performance testing (PT) programs for each specimen type are on-going since April 2000 to determine how to prepare PT materials for specimens other than urine to evaluate laboratories' ability to routinely achieve accuracy and precision required. Certification programs will be developed using the current urine drug testing National Laboratory Certification Program model. The addition of accurate and reliable workplace drug testing using hair, oral fluid, and sweat patch specimens will complement urine drug testing, and aid in combating industries devoted to suborning drug testing through adulteration, substitution, and dilution. For example, hair testing may detect chronic drug use for up to 90 days and be useful in pre-employment situations; oral fluid testing may detect drug use in past hours and be useful in post-accident situations; sweat patch testing may be useful in follow-up drug testing and treatment programs; POCTs and IITFs may be most useful for quickly identifying specimens that are negative for drugs and indicate that the specimen is valid. JF - Forensic science international AU - Bush, Donna M AD - Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, One Choke Cherry Road, Room 2-1033, Rockville, MD 20857, USA. Donna.Bush@samhsa.hhs.gov Y1 - 2008/01/30/ PY - 2008 DA - 2008 Jan 30 SP - 111 EP - 119 VL - 174 IS - 2-3 KW - Index Medicus KW - United States KW - Substance-Related Disorders -- diagnosis KW - Sweat -- chemistry KW - Saliva -- chemistry KW - Organizational Policy KW - Humans KW - Hair -- chemistry KW - United States Dept. of Health and Human Services KW - Occupational Health Services KW - Workplace KW - Mandatory Programs KW - Substance Abuse Detection -- legislation & jurisprudence KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70194762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=The+U.S.+Mandatory+Guidelines+for+Federal+Workplace+Drug+Testing+Programs%3A+current+status+and+future+considerations.&rft.au=Bush%2C+Donna+M&rft.aulast=Bush&rft.aufirst=Donna&rft.date=2008-01-30&rft.volume=174&rft.issue=2-3&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Evaluation of Modern Extraction Methods for the Analysis of Analytes Related to Food Defence T2 - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AN - 40686062; 4746495 JF - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AU - De Jager, L.S. AU - Perfetti, G A AU - Begley, T H AU - Diachenko, G W Y1 - 2008/01/28/ PY - 2008 DA - 2008 Jan 28 KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40686062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.atitle=Evaluation+of+Modern+Extraction+Methods+for+the+Analysis+of+Analytes+Related+to+Food+Defence&rft.au=De+Jager%2C+L.S.%3BPerfetti%2C+G+A%3BBegley%2C+T+H%3BDiachenko%2C+G+W&rft.aulast=De+Jager&rft.aufirst=L.S.&rft.date=2008-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ordibo.be/htc/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Cold-adapted and DNA Prime-Adenovirus Boost Vaccines for Induction of Heterosubtypic Immunity to Influenza A Virus T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40721949; 4762565 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Epstein, Suzanne L Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Vaccines KW - Influenza KW - DNA vaccines KW - Immunity KW - Disease control KW - Influenza A virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Comparison+of+Cold-adapted+and+DNA+Prime-Adenovirus+Boost+Vaccines+for+Induction+of+Heterosubtypic+Immunity+to+Influenza+A+Virus&rft.au=Epstein%2C+Suzanne+L&rft.aulast=Epstein&rft.aufirst=Suzanne&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. AN - 70248296; 18223208 AB - On June 28, 2006, the U.S. Food and Drug Administration approved dasatinib (Sprycel; Bristol-Myers Squibb), a new small-molecule inhibitor of multiple tyrosine kinases, for the treatment of adults with chronic phase, accelerated phase, or myeloid or lymphoid blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) with resistance or intolerance to prior therapy including imatinib. This summary reviews the database supporting this approval. Four single-arm multicenter studies supported the efficacy and safety of dasatinib. The primary efficacy end point in chronic phase CML was major cytogenetic response. The primary end point in accelerated phase, myeloid phase, and lymphoid blast phase CML, and Ph(+) ALL was major hematologic response. The four studies combined enrolled 445 patients. In patients with chronic phase CML, the major cytogenetic response rate was 45% with a complete cytogenetic response rate of 33%. Major hematologic response rates in patients with accelerated phase CML, myeloid CML, lymphoid blast CML, and Ph(+) ALL were 59%, 32%, 31%, and 42%, respectively. Median response durations in chronic phase, accelerated phase, and myeloid phase CML had not been reached. The median durations of major hematologic response were 3.7 months in lymphoid blast CML and 4.8 months in Ph(+) ALL. Common toxicities with dasatinib included myelosuppression, bleeding, and fluid retention. This report describes the Food and Drug Administration review supporting the approval of dasatinib for CML and Ph(+) ALL based on the rates and durability of cytogenetic and hematologic responses. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Brave, Michael AU - Goodman, Vicki AU - Kaminskas, Edvardas AU - Farrell, Ann AU - Timmer, William AU - Pope, Sarah AU - Harapanhalli, Ravi AU - Saber, Haleh AU - Morse, David AU - Bullock, Julie AU - Men, Angela AU - Noory, Carol AU - Ramchandani, Roshni AU - Kenna, Leslie AU - Booth, Brian AU - Gobburu, Joga AU - Jiang, Xiaoping AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Office of New Drugs, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. michael.brave@fda.hhs.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 352 EP - 359 VL - 14 IS - 2 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Piperazines KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Thiazoles KW - Imatinib Mesylate KW - 8A1O1M485B KW - Dasatinib KW - RBZ1571X5H KW - Index Medicus KW - United States KW - Multicenter Studies as Topic KW - Clinical Trials, Phase II as Topic KW - Protein Kinase Inhibitors -- pharmacology KW - Humans KW - Drug Resistance, Neoplasm KW - United States Food and Drug Administration KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Clinical Trials, Phase I as Topic KW - Drug Approval KW - Protein Kinase Inhibitors -- chemistry KW - Pyrimidines -- chemistry KW - Thiazoles -- chemistry KW - Pyrimidines -- adverse effects KW - Pyrimidines -- therapeutic use KW - Piperazines -- therapeutic use KW - Pyrimidines -- pharmacology KW - Thiazoles -- adverse effects KW - Leukemia, Myeloid, Chronic-Phase -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Thiazoles -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Thiazoles -- therapeutic use KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70248296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Sprycel+for+chronic+myeloid+leukemia+and+Philadelphia+chromosome-positive+acute+lymphoblastic+leukemia+resistant+to+or+intolerant+of+imatinib+mesylate.&rft.au=Brave%2C+Michael%3BGoodman%2C+Vicki%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann%3BTimmer%2C+William%3BPope%2C+Sarah%3BHarapanhalli%2C+Ravi%3BSaber%2C+Haleh%3BMorse%2C+David%3BBullock%2C+Julie%3BMen%2C+Angela%3BNoory%2C+Carol%3BRamchandani%2C+Roshni%3BKenna%2C+Leslie%3BBooth%2C+Brian%3BGobburu%2C+Joga%3BJiang%2C+Xiaoping%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Brave&rft.aufirst=Michael&rft.date=2008-01-15&rft.volume=14&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4175 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4175 ER - TY - JOUR T1 - Risk of testicular germ-cell tumours in relation to childhood physical activity AN - 20620530; 8074890 AB - The US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study of testicular germ-cell tumours (TGCTs) enrolled participants and their mothers in 2002-2005. Hours of sports or vigorous childhood physical activity per week were ascertained for three time periods; 1st-5th grades, 6th-8th grades and 9th-12th grades. Son- and mother-reports were analysed separately and included 539 control son-mother pairs and 499 case son-mother pairs. Odds ratios and 95% confidence intervals were produced. The analysis of the sons' responses found no relationship between childhood physical activity and TGCT, while the mothers' analysis found an inverse association, which was solely due to nonseminoma. Future studies should seek to validate responses further using recorded information sources such as school records. JF - British Journal of Cancer AU - Cook, M B AU - Zhang, Y AU - Graubard, B I AU - Rubertone, M V AU - Erickson, R L AU - McGlynn, KA AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS/5005, 6120 Executive Boulevard, Rockville, MD 20892-7234, USA, cookmich@mail.nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 174 EP - 178 VL - 98 IS - 1 SN - 0007-0920, 0007-0920 KW - Physical Education Index; Risk Abstracts KW - Tumors KW - Exercise KW - Children KW - Sports KW - Cancer KW - Grading KW - Schools KW - Analysis KW - physical activity KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20620530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+testicular+germ-cell+tumours+in+relation+to+childhood+physical+activity&rft.au=Cook%2C+M+B%3BZhang%2C+Y%3BGraubard%2C+B+I%3BRubertone%2C+M+V%3BErickson%2C+R+L%3BMcGlynn%2C+KA&rft.aulast=Cook&rft.aufirst=M&rft.date=2008-01-15&rft.volume=98&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604109 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Grading; Exercise; Analysis; Tumors; Sports; Schools; Cancer; physical activity; Children DO - http://dx.doi.org/10.1038/sj.bjc.6604109 ER - TY - JOUR T1 - Toll-free number for reporting adverse events on labeling for human drug products. Interim final rule. AN - 70478173; 18389912 AB - The Food and Drug Administration (FDA) is issuing an interim final rule to codify the provisions of the proposed rule entitled "Toll-Free Number for Reporting Adverse Events on Labeling for Human Drug Products" (69 FR 21778, April 22, 2004) (the toll-free number proposed rule or proposed rule) that, under the Food and Drug Administration Amendments Act of 2007 (FDAAA), became effective by operation of law on January 1, 2008. This interim final rule requires the addition of a statement on the labeling of certain human drug products for which an application is approved under the Federal Food, Drug, and Cosmetic Act (the act). The added statement includes a toll-free number and advises that the number is to be used only for reporting side effects and is not intended for medical advice (the side effects statement). As mandated by FDAAA, this interim final rule does not apply to over-the-counter drug products approved as new drugs under the act if the product packaging includes a manufacturer's or distributor's toll-free number for reporting complaints. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/01/03/ PY - 2008 DA - 2008 Jan 03 SP - 402 EP - 404 VL - 73 IS - 2 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - Humans KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Drug Labeling -- legislation & jurisprudence KW - Hotlines -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70478173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Toll-free+number+for+reporting+adverse+events+on+labeling+for+human+drug+products.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-01-03&rft.volume=73&rft.issue=2&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-25 N1 - Date created - 2008-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD AN - 19468490; 7936212 AB - The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic beta -amyloid (A beta ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ( beta -site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of A beta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. JF - Journal of Neuroscience AU - Wu, Jinfang AU - Basha, MdRiyaz AU - Brock, Brian AU - Cox, David P AU - Cardozo-Pelaez, Fernando AU - McPherson, Christopher A AU - Harry, Jean AU - Rice, Deborah C AU - Maloney, Bryan AU - Chen, Demao AU - Lahiri, Debomoy K AU - Zawia, Nasser H AD - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, National Institutes of Health, Research Triangle Park, North Carolina 27709, Maine Department of Health and Human Services, Augusta, Maine 04333, and Laboratory for Molecular Neurogenetics, Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 3 EP - 9 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 28 IS - 1 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Data processing KW - Chromium KW - Heavy metals KW - Alzheimer's disease KW - Brain KW - Cortex (frontal) KW - Transcription KW - Imprinting KW - Lead KW - Amyloidogenesis KW - Amyloid precursor protein KW - DNA damage KW - Neurodegenerative diseases KW - Sp1 protein KW - Cortex KW - beta -Site APP cleaving enzyme 1 KW - epigenetics KW - Geriatrics KW - DNA methyltransferase KW - Plaques KW - beta -Amyloid KW - Secretase KW - Infants KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Alzheimer%27s+Disease+%28AD%29-Like+Pathology+in+Aged+Monkeys+after+Infantile+Exposure+to+Environmental+Metal+Lead+%28Pb%29%3A+Evidence+for+a+Developmental+Origin+and+Environmental+Link+for+AD&rft.au=Wu%2C+Jinfang%3BBasha%2C+MdRiyaz%3BBrock%2C+Brian%3BCox%2C+David+P%3BCardozo-Pelaez%2C+Fernando%3BMcPherson%2C+Christopher+A%3BHarry%2C+Jean%3BRice%2C+Deborah+C%3BMaloney%2C+Bryan%3BChen%2C+Demao%3BLahiri%2C+Debomoy+K%3BZawia%2C+Nasser+H&rft.aulast=Wu&rft.aufirst=Jinfang&rft.date=2008-01-02&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Chromium; Heavy metals; Alzheimer's disease; Brain; Transcription; Cortex (frontal); Imprinting; Amyloidogenesis; Lead; Amyloid precursor protein; Sp1 protein; Neurodegenerative diseases; DNA damage; Cortex; beta -Site APP cleaving enzyme 1; epigenetics; Geriatrics; DNA methyltransferase; Plaques; Secretase; beta -Amyloid; Infants ER - TY - JOUR T1 - Development of a taxonomy for indexing Web-based mining safety and health research AN - 753846500; 2010-075077 JF - Publication Series - Australasian Institute of Mining and Metallurgy AU - Glowacki, A F A2 - Saydam, Serkan Y1 - 2008 PY - 2008 DA - 2008 SP - 125 EP - 129 PB - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria VL - 10/2008 SN - 1324-6240, 1324-6240 KW - occupational safety KW - mining legislation KW - mining KW - safety KW - regulations KW - data processing KW - taxonomy KW - computer networks KW - research KW - information management KW - Internet KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753846500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.atitle=Development+of+a+taxonomy+for+indexing+Web-based+mining+safety+and+health+research&rft.au=Glowacki%2C+A+F&rft.aulast=Glowacki&rft.aufirst=A&rft.date=2008-01-01&rft.volume=10%2F2008&rft.issue=&rft.spage=125&rft.isbn=9781920806927&rft.btitle=&rft.title=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.issn=13246240&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2010-01-01 N1 - Number of references - 27 N1 - PubXState - Victoria N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - computer networks; data processing; information management; Internet; mining; mining legislation; occupational safety; regulations; research; safety; taxonomy ER - TY - JOUR T1 - Possible impact of new safety technology developments on the future of the United States mining industry AN - 753845073; 2010-075071 JF - Publication Series - Australasian Institute of Mining and Metallurgy AU - Gurtunca, R G A2 - Saydam, Serkan Y1 - 2008 PY - 2008 DA - 2008 SP - 3 EP - 9 PB - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria VL - 10/2008 SN - 1324-6240, 1324-6240 KW - United States KW - occupational safety KW - mining legislation KW - mining KW - mines KW - explosions KW - natural gas KW - safety management systems KW - legislation KW - coal mines KW - petroleum KW - preventive measures KW - new methods KW - communication systems KW - ventilation KW - safety KW - future KW - coalbed methane KW - industry KW - coal deposits KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753845073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.atitle=Possible+impact+of+new+safety+technology+developments+on+the+future+of+the+United+States+mining+industry&rft.au=Gurtunca%2C+R+G&rft.aulast=Gurtunca&rft.aufirst=R&rft.date=2008-01-01&rft.volume=10%2F2008&rft.issue=&rft.spage=3&rft.isbn=9781920806927&rft.btitle=&rft.title=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.issn=13246240&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2010-01-01 N1 - Number of references - 8 N1 - PubXState - Victoria N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal deposits; coal mines; coalbed methane; communication systems; explosions; future; industry; legislation; mines; mining; mining legislation; natural gas; new methods; occupational safety; petroleum; preventive measures; safety; safety management systems; United States; ventilation ER - TY - JOUR T1 - The role of metabolic biomarkers in drug toxicity studies. AN - 734202598; 20020895 AB - ABSTRACT Metabolic profiling is a technique that can potentially provide more sensitive and specific biomarkers of toxicity than the current clinical measures benefiting preclinical and clinical drug studies. Both nuclear magnetic resonance (NMR) and mass spectrometry (MS) platforms have been used for metabolic profiling studies of drug toxicity. Not only can both techniques provide novel biomarker(s) of toxicity but the combination of both techniques gives a broader range of metabolites evaluated. Changes in metabolic patterns can provide insight into mechanism(s) of toxicity and help to eliminate a potentially toxic new chemical entity earlier in the developmental process. Metabolic profiling offers numerous advantages in toxicological research and screening as sample collection and preparation are relatively simple. Further, sample throughput, reproducibility, and accuracy are high. The area of drug toxicity of therapeutic compounds has already been impacted by metabolic profiling studies and will continue to be impacted as new, more specific biomarker(s) are found. In order for a biomarker or pattern of biomarkers to be accepted, it must be shown that they originate from the target tissue of interest. Metabolic profiling studies are amenable to any biofluid or tissue sample making it possible to link the changes noted in urine for instance as originating from renal injury. Additionally, the ease of sample collection makes it possible to follow a single animal or subject over time in order to determine whether and when the toxicity resolves itself. This review focuses on the advantages of metabolic profiling for drug toxicity studies. JF - Toxicology mechanisms and methods AU - Schnackenberg, Laura K AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, 72079-9502. Y1 - 2008 PY - 2008 DA - 2008 SP - 301 EP - 311 VL - 18 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734202598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=The+role+of+metabolic+biomarkers+in+drug+toxicity+studies.&rft.au=Schnackenberg%2C+Laura+K%3BBeger%2C+Richard+D&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2008-01-01&rft.volume=18&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510701623193 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510701623193 ER - TY - JOUR T1 - In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors. AN - 734202589; 20020915 AB - ABSTRACT Genetic toxicity testing is a critical parameter in the safety assessment of pharmaceuticals, food constituents, and environmental and industrial chemicals. Quantitative structure-activity relationship (QSAR) software offers a rapid, cost-effective means of prioritizing the genotoxic potential of chemicals. Our goal is to develop and validate a complete battery of complementary QSAR models for genetic toxicity. We previously reported the development of MDL-QSAR models for the prediction of mutations in Salmonella typhimurium and Escherichia coli ( Contrera et al. 2005b ); this report describes the development of eight additional models for mutagenicity, clastogenicity, and DNA damage. The models were created using MDL-QSAR atom-type E-state, simple connectivity and molecular property descriptor categories, and nonparametric discriminant analysis. In 10% leave-group-out internal validation studies, the specificity of the models ranged from 63% for the mouse lymphoma (L5178Y-tk) model to 88% for chromosome aberrations in vivo. Sensitivity ranged from a high of 74% for the mouse lymphoma model to a low of 39% for the unscheduled DNA synthesis model. The receiver operator characteristic (ROC) was >/=2.00, a value indicative of good predictive performance. The predictive performance of MDL-QSAR models was also shown to compare favorably to the results of MultiCase MC4PC ( Matthews et al. 2006b ) genotoxicity models prepared with the same training data sets. MDL-QSAR software models exhibit good specificity, sensitivity, and coverage and they can provide rapid and cost-effective large-scale screening of compounds for genotoxic potential by the chemical and pharmaceutical industry and for regulatory decision support applications. JF - Toxicology mechanisms and methods AU - Contrera, Joseph F AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Benz, R Daniel AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 207 EP - 216 VL - 18 IS - 2-3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734202589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=In+Silico+Screening+of+Chemicals+for+Genetic+Toxicity+Using+MDL-QSAR%2C+Nonparametric+Discriminant+Analysis%2C+E-State%2C+Connectivity%2C+and+Molecular+Property+Descriptors.&rft.au=Contrera%2C+Joseph+F%3BMatthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel&rft.aulast=Contrera&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=18&rft.issue=2-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510701857106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510701857106 ER - TY - JOUR T1 - In silico toxicological screening of natural products. AN - 734202557; 20020917 AB - ABSTRACT This study closely examines six well-known naturally occurring dietary chemicals (estragole, pulegone, aristolochic acid I, lipoic acid, 1-octacosanol, and epicatechin) with known human exposure, chemical metabolism, and mechanism of action (MOA) using in silico screening methods. The goal of this study was to take into consideration the available information on these chemicals in terms of MOA and experimentally determined toxicological data, and compare them to the in silico predictive modeling results produced from a series of computational toxicology software. After these analyses, a consensus modeling prediction was formulated in light of the weight of evidence for each natural product. We believe this approach of examining the experimentally determined mechanistic data for a given chemical and comparing it to in silico generated predictions and data mining is a valid means to evaluating the utility of the computational software, either alone or in combination with each other. We find that consensus predictions appear to be more accurate than the use of only one or two software programs and our in silico results are in very good agreement with the experimental toxicity data for the natural products screened in this study. JF - Toxicology mechanisms and methods AU - Arvidson, Kirk B AU - Valerio, Luis G AU - Diaz, Marilyn AU - Chanderbhan, Ronald F AD - Division of Food Contact Notifications, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-275, 5100 Paint Branch Parkway, College Park, MD, 20740, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 229 EP - 242 VL - 18 IS - 2-3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734202557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=In+silico+toxicological+screening+of+natural+products.&rft.au=Arvidson%2C+Kirk+B%3BValerio%2C+Luis+G%3BDiaz%2C+Marilyn%3BChanderbhan%2C+Ronald+F&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2008-01-01&rft.volume=18&rft.issue=2-3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510701856991 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510701856991 ER - TY - JOUR T1 - Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. AN - 734202146; 20020916 AB - ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development of pharmaceuticals. This report describes the construction of a database of PL findings in a variety of animal species and its use as a training data set for computational toxicology software. PL data and chemical structures were compiled from the published literature, existing pharmaceutical databases, and Food and Drug Administration (FDA) internal reports yielding a total of 583 compounds suitable for modeling. The database contained 190 (33%) positive drugs and 393 (77%) negative drugs, of which 39 were electron microscopy-confirmed negative compounds and 354 were classified as negatives due to the absence of positive reported data. Of the 190 positive findings, 76 were electron microscopy confirmed and 114 were considered positive based on other evidence. Quantitative structure-activity relationship (QSAR) models were constructed using two commercially available software programs, MC4PC and MDL-QSAR, and internal cross-validation (10 x 10%) experiments were performed to assess their predictive performance. Performance parameters for the MC4PC model were specificity 92%, sensitivity 50%, concordance 78%, positive predictivity 76%, and negative predictivity 78%. For MDL-QSAR, predictive performance was similar: specificity 80%, sensitivity 76%, concordance 79%, positive predictivity 65%, and negative predictivity 87%. By combining the output of the two QSAR programs, the overall predictive performance was vastly improved and sensitivity could be optimized to 81% without significant loss of specificity (79%). Many of the structural alerts and significant molecular descriptors obtained from the QSAR software were found to be associated with parts of active molecules known for their cationic amphiphilic drug (CAD) properties supporting the hypothesis that the endpoint of PL is statistically correlated with chemical structure. QSAR models can be useful tools for screening drug candidate molecules for potential PL. JF - Toxicology mechanisms and methods AU - Kruhlak, Naomi L AU - Choi, Sydney S AU - Contrera, Joseph F AU - Weaver, James L AU - Willard, James M AU - Hastings, Kenneth L AU - Sancilio, Lawrence F AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002. Y1 - 2008 PY - 2008 DA - 2008 SP - 217 EP - 227 VL - 18 IS - 2-3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734202146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Development+of+a+phospholipidosis+database+and+predictive+quantitative+structure-activity+relationship+%28QSAR%29+models.&rft.au=Kruhlak%2C+Naomi+L%3BChoi%2C+Sydney+S%3BContrera%2C+Joseph+F%3BWeaver%2C+James+L%3BWillard%2C+James+M%3BHastings%2C+Kenneth+L%3BSancilio%2C+Lawrence+F&rft.aulast=Kruhlak&rft.aufirst=Naomi&rft.date=2008-01-01&rft.volume=18&rft.issue=2-3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510701857262 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510701857262 ER - TY - JOUR T1 - Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents. AN - 734202085; 20020914 AB - ABSTRACT This report describes a coordinated use of four quantitative structure-activity relationship (QSAR) programs and an expert knowledge base system to predict the occurrence and the mode of action of chemical carcinogenesis in rodents. QSAR models were based upon a weight-of-evidence paradigm of carcinogenic activity that was linked to chemical structures (n = 1,572). Identical training data sets were configured for four QSAR programs (MC4PC, MDL-QSAR, BioEpisteme, and Leadscope PDM), and QSAR models were constructed for the male rat, female rat, composite rat, male mouse, female mouse, composite mouse, and rodent composite endpoints. Model predictions were adjusted to favor high specificity (>80%). Performance was shown to be affected by the method used to score carcinogenicity study findings and the ratio of the number of active to inactive chemicals in the QSAR training data set. Results demonstrated that the four QSAR programs were complementary, each detecting different profiles of carcinogens. Accepting any positive prediction from two programs showed better overall performance than either of the single programs alone; specificity, sensitivity, and Chi-square values were 72.9%, 65.9%, and 223, respectively, compared to 84.5%, 45.8%, and 151. Accepting only consensus-positive predictions using any two programs had the best overall performance and higher confidence; specificity, sensitivity, and Chi-square values were 85.3%, 57.5%, and 287, respectively. Specific examples are provided to demonstrate that consensus-positive predictions of carcinogenicity by two QSAR programs identified both genotoxic and nongenotoxic carcinogens and that they detected 98.7% of the carcinogens linked in this study to Derek for Windows defined modes of action. JF - Toxicology mechanisms and methods AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Benz, R Daniel AU - Contrera, Joseph F AU - Marchant, Carol A AU - Yang, Chihae AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993-0002, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 189 EP - 206 VL - 18 IS - 2-3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734202085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Combined+Use+of+MC4PC%2C+MDL-QSAR%2C+BioEpisteme%2C+Leadscope+PDM%2C+and+Derek+for+Windows+Software+to+Achieve+High-Performance%2C+High-Confidence%2C+Mode+of+Action-Based+Predictions+of+Chemical+Carcinogenesis+in+Rodents.&rft.au=Matthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel%3BContrera%2C+Joseph+F%3BMarchant%2C+Carol+A%3BYang%2C+Chihae&rft.aulast=Matthews&rft.aufirst=Edwin&rft.date=2008-01-01&rft.volume=18&rft.issue=2-3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510701857379 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510701857379 ER - TY - JOUR T1 - Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro. AN - 70755088; 18488416 AB - We studied the effects of a C60 water suspension at 4 microg/mL (nC60) and the water soluble fullerenol C60(OH)24 at final concentrations of 1-100 microg/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C60(OH)24 at 100 microg/mL significantly increased cell surface expression of ICAM-1(CD54) (67 +/- 4% CD54+ cells vs. 19 +/- 2 % CD540 cells in control; p < 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p < 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC60 and C60(OH)24 caused G1 arrest of HUVECs and C60(OH)24 induced significant apoptosis (21 +/- 2% TUNEL+ cells at 100 microg/mL of C60(OH)24 vs. 4 +/- 2% TUNEL+ cells in control; p < 0.001). We also demonstrated that both nC60 and C60(OH)24 induced a rapid concentration dependent elevation of intracellular calcium [Ca2+]i. This could be inhibited by EGTA, suggesting that the source of [Ca2+]i in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C60(OH)24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium. JF - International journal of nanomedicine AU - Gelderman, Monique P AU - Simakova, Olga AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Siddiqui, Sheena F AU - Vostal, Alexander C AU - Simak, Jan AD - CBER, FDA, 1401 Rockville Pike, HFM 335, Rockville, MD 20852-1448, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 59 EP - 68 VL - 3 IS - 1 SN - 1176-9114, 1176-9114 KW - Fullerenes KW - 0 KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - fullerenol KW - 182024-42-6 KW - Thromboplastin KW - 9035-58-9 KW - Index Medicus KW - Gene Expression -- drug effects KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Cell Membrane -- drug effects KW - Humans KW - Apoptosis -- drug effects KW - Cell Membrane -- metabolism KW - Endothelial Cells -- drug effects KW - Endothelial Cells -- cytology KW - Thromboplastin -- metabolism KW - Fullerenes -- adverse effects KW - Intercellular Adhesion Molecule-1 -- metabolism KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70755088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+nanomedicine&rft.atitle=Adverse+effects+of+fullerenes+on+endothelial+cells%3A+fullerenol+C60%28OH%2924+induced+tissue+factor+and+ICAM-I+membrane+expression+and+apoptosis+in+vitro.&rft.au=Gelderman%2C+Monique+P%3BSimakova%2C+Olga%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BSiddiqui%2C+Sheena+F%3BVostal%2C+Alexander+C%3BSimak%2C+Jan&rft.aulast=Gelderman&rft.aufirst=Monique&rft.date=2008-01-01&rft.volume=3&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=International+journal+of+nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Mol Life Sci. 2005 May;62(9):971-88 [15761668] Antimicrob Agents Chemother. 1999 Sep;43(9):2273-7 [10471578] Biomaterials. 2005 Dec;26(36):7587-95 [16005959] IEEE Trans Nanobioscience. 2005 Jun;4(2):180-95 [16117026] Curr Opin Chem Biol. 2005 Dec;9(6):674-9 [16233988] Nano Lett. 2005 Dec;5(12):2578-85 [16351219] Circulation. 2006 Feb 7;113(5):722-31 [16461845] Toxicol Sci. 2006 May;91(1):173-83 [16476688] Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415] Mar Environ Res. 2006 Jul;62 Suppl:S5-9 [16709433] Environ Sci Technol. 2006 Jul 15;40(14):4360-6 [16903271] J Nanosci Nanotechnol. 2006 Jul;6(7):1883-904 [17025102] Biomaterials. 2007 Jan;28(2):344-53 [16934866] Adv Drug Deliv Rev. 2006 Dec 1;58(14):1460-70 [17113677] Clin Cancer Res. 2006 Dec 1;12(23):7086-91 [17145832] J BUON. 2006 Oct-Dec;11(4):391-404 [17309168] Eur J Biochem. 1998 May 15;254(1):38-43 [9652391] J Med Chem. 1999 Nov 4;42(22):4614-20 [10579823] World J Surg. 2000 Apr;24(4):450-4 [10706918] Arch Biochem Biophys. 2000 Jun 15;378(2):216-23 [10860539] J Neurosci Res. 2000 Nov 15;62(4):600-7 [11070504] Transfusion. 2002 Mar;42(3):334-42 [11961239] BMC Cell Biol. 2002 May 28;3:11 [12052248] Eur J Med Chem. 2003 Nov-Dec;38(11-12):913-23 [14642323] Environ Health Perspect. 2004 Jul;112(10):1058-62 [15238277] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2223-38 [15370479] Carcinogenesis. 1996 Oct;17(10):2163-9 [8895484] Antiviral Res. 1997 Mar;34(1):65-70 [9107386] J Pharm Pharmacol. 1997 Apr;49(4):438-45 [9232545] Neurobiol Dis. 1996 Apr;3(2):129-35 [9173920] Tissue Antigens. 1997 Nov;50(5):449-58 [9389318] Jpn J Cancer Res. 1997 Nov;88(11):1108-16 [9439687] Toxicol Pathol. 1998 Jan-Feb;26(1):143-51 [9502397] Br J Pharmacol. 1998 Mar;123(6):1097-102 [9559892] Chem Biol Interact. 1998 Jul 24;114(3):145-59 [9839628] J Neurochem. 1999 Apr;72(4):1634-40 [10098871] FEBS Lett. 1999 Jul 9;454(3):335-40 [10431834] Environ Sci Technol. 2005 Jun 1;39(11):4307-16 [15984814] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clostridium difficile: from obscurity to superbug. AN - 70737461; 18476496 AB - According to the UK media and popular press, Clostridium difficile is now a fully fledged member of that notorious but ill-defined group of microorganisms portrayed to the general public as superbugs. Following the trail blazed by methicillin-resistant Staphylococcus aureus (MRSA), C. difficile has made the transition from being an obscure anaerobic bacterium, mainly of interest to specialist anaerobic microbiologists, to that of an infamous superbug responsible for outbreaks of hospital-acquired infection that commonly result in serious disease and death. This review tracks the rise in scientific knowledge and public awareness of this organism. JF - British journal of biomedical science AU - Brazier, J S AD - Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology, Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK. brazier@cardiff.ac.uk Y1 - 2008 PY - 2008 DA - 2008 SP - 39 EP - 44 VL - 65 IS - 1 SN - 0967-4845, 0967-4845 KW - Cytotoxins KW - 0 KW - Nucleic Acids KW - Index Medicus KW - Animals KW - Newspapers as Topic KW - United Kingdom -- epidemiology KW - Molecular Epidemiology KW - Guinea Pigs KW - Humans KW - Nucleic Acids -- genetics KW - Cytotoxins -- analysis KW - Cricetinae KW - Feces -- microbiology KW - Enterocolitis, Pseudomembranous -- diagnosis KW - Clostridium difficile -- isolation & purification KW - Enterocolitis, Pseudomembranous -- epidemiology KW - Clostridium difficile -- pathogenicity KW - Cross Infection -- epidemiology KW - Clostridium difficile -- genetics KW - Disease Outbreaks KW - Feces -- chemistry KW - Enterocolitis, Pseudomembranous -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70737461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+biomedical+science&rft.atitle=Clostridium+difficile%3A+from+obscurity+to+superbug.&rft.au=Brazier%2C+J+S&rft.aulast=Brazier&rft.aufirst=J&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=British+journal+of+biomedical+science&rft.issn=09674845&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity of kava kava. AN - 70373909; 18322868 AB - Kava is a traditional beverage of various Pacific Basin countries. Kava has been introduced into the mainstream U.S. market principally as an anti-anxiety preparation. The effects of the long-term consumption of kava have not been documented adequately. Preliminary studies suggest possible serious organ system effects. The potential carcinogenicity of kava and its principal constituents are unknown. As such, kava extract was nominated for the chronic tumorigenicity bioassay conducted by the National Toxicology Program (NTP). At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Fu, Peter P AU - Xia, Qingsu AU - Guo, Lei AU - Yu, Hongtao AU - Chan, Po-Chuen AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. peter.fu@fda.hhs.gov PY - 2008 SP - 89 EP - 112 VL - 26 IS - 1 KW - Plant Extracts KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Drug and Narcotic Control KW - Humans KW - Cats KW - Toxicity Tests KW - Dogs KW - Rabbits KW - Mice KW - Liver -- pathology KW - Plant Extracts -- metabolism KW - Liver -- drug effects KW - Plant Extracts -- toxicity KW - Plant Extracts -- pharmacokinetics KW - Kava -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Toxicity+of+kava+kava.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BGuo%2C+Lei%3BYu%2C+Hongtao%3BChan%2C+Po-Chuen&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=26&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590500801907407 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-12 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10590500801907407 ER - TY - JOUR T1 - Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions. AN - 70351342; 18312033 AB - To present nationally representative data on the lifetime prevalence and population estimates of violent behavior among individuals with DSM-IV psychiatric disorders. The data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions. Prevalences, population estimates, and associations of violent behavior occurring among individuals with pure, comorbid, and specific DSM-IV psychiatric disorders were examined. After controlling for sociodemographic characteristics and other comorbidity, it was found that the odds of violent behavior were significantly increased (p < .05) among individuals with substance use disorders; pathological gambling; major depressive disorder; bipolar disorders; panic disorder without agoraphobia; specific phobia; and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders. Percentages of violent behavior among individuals with each comorbid disorder were, with few exceptions, significantly greater (p < .05-p < .001) than the corresponding percentages among those presenting with the pure form of each disorder. Alcohol and drug use disorders were the most significant contributors to the public health burden of violent behavior. The majority of individuals with psychiatric disorders do not engage in violent behavior, and public perception associated with stereotypic violence among individuals with psychiatric disorders appears unwarranted. Elevated risks and burden of violent behavior were not equally shared across the spectrum of psychiatric disorders, with particular disorders, especially substance use disorders, contributing disproportionately to the burden. Future research should examine the circumstances under which violence among individuals with psychiatric disorders occurs with a view toward improving clinical prediction and developing more effective prevention strategies. JF - The Journal of clinical psychiatry AU - Pulay, Attila J AU - Dawson, Deborah A AU - Hasin, Deborah S AU - Goldstein, Risë B AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. 20892-9304, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 12 EP - 22 VL - 69 IS - 1 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- psychology KW - Ethnic Groups -- psychology KW - Ethnic Groups -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Violence -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Violence -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70351342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Violent+behavior+and+DSM-IV+psychiatric+disorders%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BHasin%2C+Deborah+S%3BGoldstein%2C+Ris%C3%AB+B%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2008-01-01&rft.volume=69&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Subst Abuse. 1997;9:127-35 [9494944] Am J Psychiatry. 1998 Feb;155(2):226-31 [9464202] Eur Addict Res. 1998 Dec;4(4):144-9 [9852366] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S1-6 [9857773] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S13-23 [9857775] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S55-60 [9857780] Alcohol Clin Exp Res. 1999 Jan;23(1):144-50 [10029216] Arch Gen Psychiatry. 2004 Nov;61(11):1107-15 [15520358] J Consult Clin Psychol. 2004 Dec;72(6):1114-21 [15612857] J Clin Psychiatry. 2005 May;66(5):564-74 [15889941] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Subst Abuse Treat. 2005 Jul;29(1):5-17 [15979527] Psychiatry Res. 2005 Sep 15;136(2-3):153-62 [16125786] Arch Gen Psychiatry. 2005 Oct;62(10):1097-106 [16203955] J Clin Psychiatry. 2005 Oct;66(10):1205-15 [16259532] Psychol Med. 2005 Dec;35(12):1747-59 [16202187] J Clin Psychiatry. 2005 Nov;66(11):1351-61 [16420070] J Clin Psychiatry. 2006 Mar;67(3):363-74 [16649821] Am J Epidemiol. 2006 Dec 15;164(12):1199-208 [17032695] Arch Gen Psychiatry. 2007 May;64(5):566-76 [17485608] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Drug Alcohol Abuse. 2000 May;26(2):161-77 [10852354] Arch Gen Psychiatry. 2000 Oct;57(10):979-86 [11015816] Alcohol Res Health. 2001;25(1):58-65 [11496968] Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684] Acta Psychiatr Scand Suppl. 2004;(424):5-59 [15447785] J Psychiatr Res. 2005 Jan;39(1):1-9 [15504418] Hosp Community Psychiatry. 1990 Jul;41(7):761-70 [2142118] Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Arch Gen Psychiatry. 1994 Mar;51(3):225-45 [8122959] Addiction. 1994 May;89(5):573-9 [8044123] J Consult Clin Psychol. 1995 Apr;63(2):256-62 [7751486] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Epidemiol Rev. 1995;17(1):172-81 [8521935] Drug Alcohol Depend. 1997 Mar 14;44(2-3):133-41 [9088785] Psychiatry. 1997 Spring;60(1):1-22 [9130311] Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] Drug Alcohol Depend. 1997 Sep 25;47(3):217-26 [9306047] Arch Gen Psychiatry. 1998 May;55(5):393-401 [9596041] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - How useful are voluntary medication error reports? The case of warfarin-related medication errors. AN - 70300757; 18277800 AB - A study was conducted to explore the value and limitations of voluntary medical error reports and to learn about common errors in warfarin use. Voluntary reports of 8,837 inpatient errors and 820 outpatient errors in warfarin use submitted by 445 hospitals and 192 outpatient facilities participating in MEDMARX, a voluntary medication error reporting system, from 2002 to 2004, were gathered. Overall, errors occurred most often during transcription/documentation (35%) and administration (30%) in hospitals, and during prescribing (31%) and dispensing (39%) in outpatient settings. Dosing errors were the most common type. In hospitals, more than 50% of reported errors were initiated by nurses, and 50% were intercepted by nurses, whereas in outpatient settings, about 50% of reported errors occurred in pharmacies and 50% were intercepted by pharmacists. About 17% of inpatient and 13% of outpatient warfarin errors resulted in changes in patient care, and 42% of inpatient and 62% of outpatient errors resulted in procedural changes. Cascade analysis and textual descriptions further located specific, correctible safety lapses. Voluntary medical error reporting systems can, to some extent, provide meaningful and actionable information to guide patient safety improvement, but their usefulness is limited because of a lack of details, incomplete reporting, underreporting, and various reporting biases. JF - Joint Commission journal on quality and patient safety AU - Zhan, Chunliu AU - Smith, Scott R AU - Keyes, Margaret A AU - Hicks, Rodney W AU - Cousins, Diane D AU - Clancy, Carolyn M AD - Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services, Rockville, Maryland, USA. czhan@ahrq.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 36 EP - 45 VL - 34 IS - 1 SN - 1553-7250, 1553-7250 KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - United States KW - Hospitals -- standards KW - Humans KW - Quality Assurance, Health Care -- methods KW - Program Evaluation KW - Ambulatory Care Facilities -- standards KW - Truth Disclosure KW - Safety Management KW - Male KW - Female KW - Medication Errors -- classification KW - Warfarin -- adverse effects KW - Risk Management KW - Warfarin -- administration & dosage KW - Medication Errors -- statistics & numerical data KW - Voluntary Programs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Joint+Commission+journal+on+quality+and+patient+safety&rft.atitle=How+useful+are+voluntary+medication+error+reports%3F+The+case+of+warfarin-related+medication+errors.&rft.au=Zhan%2C+Chunliu%3BSmith%2C+Scott+R%3BKeyes%2C+Margaret+A%3BHicks%2C+Rodney+W%3BCousins%2C+Diane+D%3BClancy%2C+Carolyn+M&rft.aulast=Zhan&rft.aufirst=Chunliu&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Joint+Commission+journal+on+quality+and+patient+safety&rft.issn=15537250&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The potential utility of HPV genotyping in screening and clinical management. AN - 70285584; 18267061 AB - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management. JF - Journal of the National Comprehensive Cancer Network : JNCCN AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 83 EP - 95 VL - 6 IS - 1 SN - 1540-1405, 1540-1405 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Genotype KW - Mass Screening KW - DNA, Viral -- analysis KW - Humans KW - Decision Trees KW - Female KW - Uterine Cervical Neoplasms -- therapy KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- diagnosis KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- pathology KW - Cervical Intraepithelial Neoplasia -- therapy KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- therapy KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.atitle=The+potential+utility+of+HPV+genotyping+in+screening+and+clinical+management.&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=6&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.issn=15401405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computer-controlled ozone inhalation exposure system. AN - 70254802; 18236221 AB - Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized. JF - Inhalation toxicology AU - McKinney, Walter AU - Frazer, Dave AD - Centers for Disease Control/National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. wdm9@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 43 EP - 48 VL - 20 IS - 1 KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Software KW - Animals KW - Computer Systems KW - Atmosphere Exposure Chambers KW - Ozone -- administration & dosage KW - Ozone -- adverse effects KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70254802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Computer-controlled+ozone+inhalation+exposure+system.&rft.au=McKinney%2C+Walter%3BFrazer%2C+Dave&rft.aulast=McKinney&rft.aufirst=Walter&rft.date=2008-01-01&rft.volume=20&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370701758544 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08958370701758544 ER - TY - JOUR T1 - Chronic inhalation of short asbestos: lung fiber burdens and histopathology for monkeys maintained for 11.5 years after exposure. AN - 70251555; 18236224 AB - In an earlier report, Platek et al. (1985) presented the results of an 18-month inhalation exposure of rats and monkeys to short chrysotile asbestos. The mean chamber exposure level was 1.0 mg/m(3) with an average of 0.79 fibers/ml > 5 microm in length. Gross and histopathological examination of exposed and control rats indicated no treatment-related lesions. Asbestos bodies adjacent to the terminal bronchioles, but no fibrosis, were found in lung biopsy tissue taken from the exposed monkeys at 10 months post-exposure. Fifteen monkeys (9 exposed and 6 controls) from this study were maintained for 11.5 years following exposure. Lung fiber burdens were determined by transmission electron microscopy. The mean lung burden (+/- standard deviation) for 59 samples from exposed monkeys was 63 +/- 30 x 10(6) fibers/g dry lung (range, 18-139 x 10(6)). The geometric mean fiber length was 3.5 microm with 35% of the fibers being > 5 microm in length. These data indicate some chrysotile fibers are durable in vivo for a significant period of time. Lungs were examined grossly and microscopically. No lesions attributable to the inhalation exposure were noted. Asbestos bodies were seen in the lungs of treated monkeys, primarily in the interstitium near bronchioles or small pulmonary blood vessels (which also may have been near to bronchioles just out of the plane of section). JF - Inhalation toxicology AU - Stettler, Lloyd E AU - Sharpnack, Douglas D AU - Krieg, Edward F AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45040, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 63 EP - 73 VL - 20 IS - 1 KW - Asbestos, Serpentine KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Animals KW - Time KW - Macaca fascicularis KW - Particle Size KW - Asbestos, Serpentine -- administration & dosage KW - Male KW - Asbestos, Serpentine -- adverse effects KW - Asbestos -- administration & dosage KW - Lung -- drug effects KW - Asbestos -- adverse effects KW - Lung -- pathology KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70251555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Chronic+inhalation+of+short+asbestos%3A+lung+fiber+burdens+and+histopathology+for+monkeys+maintained+for+11.5+years+after+exposure.&rft.au=Stettler%2C+Lloyd+E%3BSharpnack%2C+Douglas+D%3BKrieg%2C+Edward+F&rft.aulast=Stettler&rft.aufirst=Lloyd&rft.date=2008-01-01&rft.volume=20&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370701665566 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08958370701665566 ER - TY - JOUR T1 - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. AN - 70247730; 17984110 AB - Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 891 biliary (gallbladder or bile duct) stone cases and 786 population controls conducted in Shanghai, China. Compared with subjects carrying the XRCC1 194RR genotype, those with the WW genotype had a 1.9-fold risk of bile duct cancer [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.5, P(trend) = 0.03], and compared with subjects carrying the XRCC1 280RR genotype, those with the XRCC1 280H allele had a 50% reduced risk of bile duct cancer (OR = 0.5, 95% CI = 0.3-0.9, P(trend) = 0.05). The effect of the R280H polymorphism persisted (P(trend) = 0.03), when all three XRCC1 polymorphisms were jointly considered in the model, a finding supported by the haplotype results (covariate-adjusted global permutation P = 0.03). We also found an inverse association between the APEX1 148E allele and gallbladder stones (P(trend) = 0.03), but no association for the OGG1 polymorphism. This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations. JF - Carcinogenesis AU - Huang, Wen-Yi AU - Gao, Yu-Tang AU - Rashid, Asif AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chanock, Stephen J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 100 EP - 105 VL - 29 IS - 1 KW - Index Medicus KW - Genotype KW - Humans KW - China -- epidemiology KW - Case-Control Studies KW - DNA Repair -- genetics KW - Gallstones -- epidemiology KW - Biliary Tract Neoplasms -- epidemiology KW - Polymorphism, Genetic KW - Biliary Tract Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Gallstones -- genetics KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70247730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Selected+base+excision+repair+gene+polymorphisms+and+susceptibility+to+biliary+tract+cancer+and+biliary+stones%3A+a+population-based+case-control+study+in+China.&rft.au=Huang%2C+Wen-Yi%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChanock%2C+Stephen+J%3BHsing%2C+Ann+W&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of oligonucleotide microarray technology to toxic occupational exposures. AN - 70242100; 18214805 AB - Microarray technology has advanced toward analysis of toxic occupational exposures in biological systems. Microarray analysis is an ideal way to search for biomarkers of exposure, even if no specific gene or pathway has been identified. Analysis may now be performed on thousands of genes simultaneously, as opposed to small numbers of genes as in the past. This ability has been put to use to analyze gene expression profiles of a variety of occupational toxins in animal models to classify toxins into specific categories based on response. Analysis of normal human cell strains allows an extension of this analysis to investigate the role of interindividual variation in response to various toxins. This methodology was used to analyze four occupationally related toxins in our lab: oxythioquinox (OTQ), a quinoxaline pesticide; malathion, an organophosphate pesticide; di-n-butyl phthalate (DBP), a chemical commonly found in personal care and cosmetic items; and benzo[a]pyrene (BaP), an environmental and occupational carcinogen. The results for each exposure highlighted signaling pathways involved in response to these occupational exposures. Both pesticides showed increase in metabolic enzymes, while DBP showed alterations in genes related to fertility. BaP exposure showed alterations in two cytochrome P450s related to carcinogenicity. When used with occupational exposure information, these data may be used to augment risk assessment to make the workplace safer for a greater proportion of the workforce, including individuals susceptible to disease related to exposures. JF - Journal of toxicology and environmental health. Part A AU - Gwinn, Maureen R AU - Weston, Ainsley AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 315 EP - 324 VL - 71 IS - 5 SN - 1528-7394, 1528-7394 KW - Carcinogens, Environmental KW - 0 KW - Pesticides KW - Plasticizers KW - Quinoxalines KW - Dibutyl Phthalate KW - 2286E5R2KE KW - quinomethionate KW - 2439-01-2 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Malathion KW - U5N7SU872W KW - Index Medicus KW - Benzo(a)pyrene -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Pesticides -- pharmacology KW - Risk Assessment KW - Environmental Monitoring KW - Malathion -- pharmacology KW - Genes, p53 KW - Signal Transduction -- genetics KW - Dibutyl Phthalate -- pharmacology KW - Plasticizers -- pharmacology KW - Quinoxalines -- pharmacology KW - Cell Line KW - Mammary Glands, Human -- drug effects KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Occupational Exposure -- adverse effects KW - Carcinogens, Environmental -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70242100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Application+of+oligonucleotide+microarray+technology+to+toxic+occupational+exposures.&rft.au=Gwinn%2C+Maureen+R%3BWeston%2C+Ainsley&rft.aulast=Gwinn&rft.aufirst=Maureen&rft.date=2008-01-01&rft.volume=71&rft.issue=5&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390701738509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-06 N1 - Date created - 2008-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287390701738509 ER - TY - JOUR T1 - Determination of caffeine and sympathomimetic alkaloids in weight loss supplements by high-performance liquid chromatography. AN - 70240570; 18218190 AB - Reversed-phase high-performance liquid chromatography utilizing photodiode array detection is used for the simultaneous determination of caffeine and nine alkaloids from Citrus aurantium (CA) and ephedra (EA) contained in dietary weight loss products. Since the Food and Drug Administration (FDA) ban of EA, manufacturers have substituted CA in their weight loss formulations, usually combined with high levels of caffeine. The alkaloids contained in CA have some physiological effects similar to those of the EA alkaloids and are, therefore, cause for concern. Caffeine has been shown to potentiate the toxicity of the EA alkaloids. Recently, a federal judge overturned the absolute ban and allowed marketing of low levels (<10 mg/day) of total EA alkaloids. To support an absolute ban, the FDA is now compelled to perform dose-dependent toxicology studies to determine the toxic dose(s) of EA. The toxicity of the CA compounds is largely unknown, especially in combination with caffeine. The described method enables quantitation over a wide range of product formulations. Recoveries range from 91% to 100% from a variety of fortified plant matrices. JF - Journal of chromatographic science AU - Evans, Ronald L AU - Siitonen, Paul H AD - National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Division of Biochemical Toxicology, Jefferson, AR 72079, USA. ronald.evans@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 61 EP - 67 VL - 46 IS - 1 SN - 0021-9665, 0021-9665 KW - Alkaloids KW - 0 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Reproducibility of Results KW - Chromatography, High Pressure Liquid -- methods KW - Caffeine -- analysis KW - Alkaloids -- analysis KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70240570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+caffeine+and+sympathomimetic+alkaloids+in+weight+loss+supplements+by+high-performance+liquid+chromatography.&rft.au=Evans%2C+Ronald+L%3BSiitonen%2C+Paul+H&rft.aulast=Evans&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents. AN - 70239595; 17879298 AB - Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development. JF - Environmental and molecular mutagenesis AU - Pogribny, Igor P AU - Rusyn, Ivan AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 EP - 15 VL - 49 IS - 1 SN - 0893-6692, 0893-6692 KW - Index Medicus KW - Animals KW - DNA Damage KW - Humans KW - Disease Models, Animal KW - Rodentia KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- physiopathology KW - Carcinoma, Hepatocellular -- physiopathology KW - Epigenesis, Genetic KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70239595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Epigenetic+aspects+of+genotoxic+and+non-genotoxic+hepatocarcinogenesis%3A+studies+in+rodents.&rft.au=Pogribny%2C+Igor+P%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2008-01-01&rft.volume=49&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-28 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Surg Res. 2006 Nov;136(1):125-35 [17023002] Pathol Int. 1999 Dec;49(12):1028-42 [10632923] Cell. 2007 Feb 23;128(4):683-92 [17320506] Mol Carcinog. 2007 Mar;46(3):187-97 [17219426] Cell. 2000 Jan 7;100(1):57-70 [10647931] Toxicol Sci. 2000 Apr;54(2):399-407 [10774822] J Environ Pathol Toxicol Oncol. 2000;19(3):281-6 [10983894] Regul Toxicol Pharmacol. 2000 Oct;32(2):135-43 [11067770] Mol Carcinog. 2001 Mar;30(3):138-50 [11301474] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Toxicol Lett. 2002 Aug 5;134(1-3):51-6 [12191860] Cancer Lett. 2002 Dec 10;187(1-2):69-75 [12359353] Int J Cancer. 2003 Jul 1;105(4):527-32 [12712445] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Am J Pathol. 2003 Sep;163(3):1101-7 [12937151] Am J Pathol. 2003 Oct;163(4):1371-8 [14507645] Oncogene. 2003 Sep 25;22(41):6319-31 [14508512] J Nutr. 2003 Nov;133(11 Suppl 1):3740S-3747S [14608108] J Natl Cancer Inst. 2003 Dec 3;95(23):1747-57 [14652236] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Adv Cancer Res. 2003;90:209-30 [14710952] Nat Rev Cancer. 2004 Feb;4(2):143-53 [14732866] EMBO J. 2004 Feb 11;23(3):605-15 [14765126] Science. 2004 Mar 12;303(5664):1626-32 [15016989] Mutat Res. 2004 Apr 14;548(1-2):53-9 [15063136] Toxicol Lett. 2004 Apr 1;149(1-3):51-8 [15093248] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Lab Invest. 2004 Sep;84(9):1137-47 [15220935] Semin Cancer Biol. 2004 Dec;14(6):427-32 [15489135] Carcinogenesis. 1989 May;10(5):933-7 [2650909] Biochem Pharmacol. 1991 Jul 5;42(2):365-71 [1859451] Cancer Res. 1992 Apr 1;52(7 Suppl):2071s-2077s [1544143] Cancer Res. 1992 Sep 15;52(18):5042-5 [1516060] Trends Genet. 1997 Aug;13(8):335-40 [9260521] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Hepatogastroenterology. 1998 Sep-Oct;45(23):1753-9 [9840141] Mutat Res. 1999 Mar 8;424(1-2):97-106 [10064853] Cell. 2004 Nov 24;119(5):603-14 [15550243] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Liver Int. 2005 Feb;25(1):16-27 [15698394] Nat Genet. 2005 Apr;37(4):391-400 [15765097] Eur J Gastroenterol Hepatol. 2005 May;17(5):477-83 [15827436] Annu Rev Biochem. 2005;74:481-514 [15952895] Carcinogenesis. 2005 Aug;26(8):1323-34 [15802302] Hepatology. 2005 Nov;42(5):1137-47 [16250055] EXS. 2006;(96):321-49 [16383025] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] Cancer Lett. 2006 Feb 28;233(2):271-8 [15885882] Toxicol Sci. 2006 Apr;90(2):317-25 [16396840] J Nutr. 2006 Jun;136(6):1522-7 [16702315] Carcinogenesis. 2006 Jun;27(6):1180-6 [16497704] FEBS J. 2006 Jul;273(14):3121-35 [16857008] Curr Top Microbiol Immunol. 2006;310:211-50 [16909913] Mol Carcinog. 2007 Apr;46(4):269-74 [17295234] Oncogene. 2007 Apr 2;26(15):2166-76 [17401425] Hum Mol Genet. 2007 Jun 1;16(11):1335-42 [17412760] Cancer Res. 2007 Jun 15;67(12):5583-6 [17575120] Mutagenesis. 2007 Jul;22(4):247-53 [17412712] Mutat Res. 2007 Dec 1;625(1-2):62-71 [17586532] Toxicol Sci. 2007 Mar;96(1):72-82 [17172636] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System. AN - 70219372; 18206508 AB - The National Electronic Injury Surveillance System (NEISS) captures a nationally representative probability sample from hospital emergency departments (EDs) in the United States. Emergency department data from NEISS were analyzed to assess the magnitude and severity of adverse events attributable to food allergies. Emergency department events describing food-related allergic symptomatology were identified from 34 participating EDs from August 1 to September 30, 2003. Extrapolation of NEISS event data predicts a total of 20,821 hospital ED visits, 2333 visits for anaphylaxis, and 520 hospitalizations caused by food allergy in the United States during the 2-month study period. The median age was 26 years; 24% of visits involved children or =6 years old, whereas children < or =5 years old experienced more events from eggs, fruit, peanuts, and tree nuts. There were no reported deaths. Review of medical records found that only 19% of patients received epinephrine, and, using criteria established by a 2005 anaphylaxis symposium, 57% of likely anaphylactic events did not have an ED diagnosis of anaphylaxis. Analysis of NEISS data may be a useful tool for assessing the magnitude and severity of food-allergic events. A criteria-based review of medical records suggests underdiagnosis of anaphylactic events in EDs. JF - The Journal of allergy and clinical immunology AU - Ross, Marianne Phelan AU - Ferguson, Martine AU - Street, Debra AU - Klontz, Karl AU - Schroeder, Tom AU - Luccioli, Stefano AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. Marianne.Ross@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 166 EP - 171 VL - 121 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - Anaphylaxis -- epidemiology KW - Nuts -- adverse effects KW - Food Hypersensitivity -- etiology KW - Food Hypersensitivity -- epidemiology KW - Humans KW - Child KW - Fruit -- adverse effects KW - Child, Preschool KW - Infant KW - Shellfish -- adverse effects KW - Eggs -- adverse effects KW - Peanut Hypersensitivity KW - Adult KW - Anaphylaxis -- etiology KW - Emergency Service, Hospital -- statistics & numerical data KW - Adolescent KW - Hospitalization -- statistics & numerical data KW - United States -- epidemiology KW - Adverse Drug Reaction Reporting Systems KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70219372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Analysis+of+food-allergic+and+anaphylactic+events+in+the+National+Electronic+Injury+Surveillance+System.&rft.au=Ross%2C+Marianne+Phelan%3BFerguson%2C+Martine%3BStreet%2C+Debra%3BKlontz%2C+Karl%3BSchroeder%2C+Tom%3BLuccioli%2C+Stefano&rft.aulast=Ross&rft.aufirst=Marianne&rft.date=2008-01-01&rft.volume=121&rft.issue=1&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2007.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2007.10.012 ER - TY - JOUR T1 - Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. AN - 70211274; 18197312 AB - Conflicting views have been expressed frequently on assessments of human cancer risk of environmental agents based on animal carcinogenicity data; this is primarily because of uncertainties associated with extrapolations of toxicologic findings from studies in experimental animals to human circumstances. Underlying these uncertainties are issues related to how experiments are designed, how rigorously hypotheses are tested, and to what extent assertions extend beyond actual findings. National and international health agencies regard carcinogenicity findings in well-conducted experimental animal studies as evidence of potential carcinogenic risk to humans. Controversies arise when both positive and negative carcinogenicity data exist for a specific agent or when incomplete mechanistic data suggest a possible species difference in response. Issues of experimental design and evaluation that might contribute to disparate results are addressed in this article. To serve as reliable sources of data for the evaluation of the carcinogenic potential of environmental agents, experimental studies must include a) animal models that are sensitive to the end points under investigation; b) detailed characterization of the agent and the administered doses; c) challenging doses and durations of exposure (at least 2 years for rats and mice); d) sufficient numbers of animals per dose group to be capable of detecting a true effect; e) multiple dose groups to allow characterization of dose-response relationships, f) complete and peer-reviewed histopathologic evaluations; and g) pairwise comparisons and analyses of trends based on survival-adjusted tumor incidence. Pharmacokinetic models and mechanistic hypotheses may provide insights into the biological behavior of the agent; however, they must be adequately tested before being used to evaluate human cancer risk. JF - Environmental health perspectives AU - Melnick, Ronald L AU - Thayer, Kristina A AU - Bucher, John R AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. melnickr@niehs.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 130 EP - 135 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - tumor pathology KW - maximally tolerated dose KW - statistical power KW - mode of action KW - rodent cancer bioassay KW - dose selection KW - Rats KW - Animals KW - Public Health KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests -- methods KW - Mice KW - Research Design KW - Risk Assessment KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Conflicting+views+on+chemical+carcinogenesis+arising+from+the+design+and+evaluation+of+rodent+carcinogenicity+studies.&rft.au=Melnick%2C+Ronald+L%3BThayer%2C+Kristina+A%3BBucher%2C+John+R&rft.aulast=Melnick&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Natl Toxicol Program Tech Rep Ser. 2006 Feb;(533):1-264 [16741556] J Cancer Res Clin Oncol. 1999;125(3-4):219-25 [10235477] Carcinogenesis. 2000 Apr;21(4):823-6 [10753222] J Cancer Res Clin Oncol. 2000 Apr;126(4):246 [10782899] IARC Monogr Eval Carcinog Risks Hum. 1999;73:339-83 [10804962] Environ Health Perspect. 2000 May;108 Suppl 2:265-73 [10807557] Environ Health Perspect. 2000 May;108 Suppl 2:283-305 [10807559] Toxicol Sci. 2000 Jun;55(2):433-43 [10828276] IARC Monogr Eval Carcinog Risks Hum. 2000;77:41-148 [11100399] FASEB J. 2001 Jan;15(1):195-203 [11149907] Food Chem Toxicol. 2001 Jul;39(7):739-44 [11397520] Environ Health Perspect. 2001 May;109(5):437-42 [11401753] Toxicol Pathol. 1984;12(2):126-35 [11478313] Int J Occup Environ Health. 2002 Apr-Jun;8(2):144-52 [12019681] Br J Cancer. 2003 Jan 13;88(1):84-9 [12556964] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Toxicol Sci. 2003 Sep;75(1):7-15 [12805639] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Environ Health Perspect. 2004 Sep;112(13):1269-74 [15345338] Arch Toxicol. 1977 Jul 19;37(3):233-6 [332116] Natl Cancer Inst Monogr. 1979 May;(51):25-35 [481577] Food Chem Toxicol. 1983 Dec;21(6):825-32 [6363233] Arch Toxicol. 1984 Oct;55(4):213-8 [6517696] Environ Health Perspect. 1984 Dec;58:385-92 [6525993] Toxicol Pathol. 1983;11(1):77-82 [6681400] J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066] Am Ind Hyg Assoc J. 1987 May;48(5):407-13 [3591659] Fundam Appl Toxicol. 1988 Apr;10(3):385-94 [3286346] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Environ Health Perspect. 1989 Jul;82:109-24 [2792037] Environ Health Perspect. 1989 Jul;82:125-63 [2676495] IARC Sci Publ. 1989;(96):17-34 [2553598] Occup Environ Med. 1999 Mar;56(3):181-90 [10448327] IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 1:109-225 [10476446] N Engl J Med. 2005 Jul 14;353(2):116-8 [16014880] Natl Toxicol Program Tech Rep Ser. 2005 Sep;(494):1-358 [16362060] Natl Toxicol Program Tech Rep Ser. 2005 Dec;(517):1-255 [16362061] Cancer Res. 1990 Oct 15;50(20):6592-9 [2208121] Rev Environ Contam Toxicol. 1992;124:111-44 [1732994] Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] IARC Monogr Eval Carcinog Risks Hum. 1994;60:73-159 [7869582] Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775] Fundam Appl Toxicol. 1995 Aug;27(1):95-105 [7589934] Toxicol Lett. 1995 Sep;79(1-3):107-14 [7570646] Biochim Biophys Acta. 1996 Jul 26;1302(2):93-109 [8695669] Fundam Appl Toxicol. 1996 May;31(1):1-8 [8998945] Ann N Y Acad Sci. 1996 Dec 27;804:252-65 [8993548] J Appl Toxicol. 1997 May;17 Suppl 1:S45-55 [9179727] IARC Monogr Eval Carcinog Risks Hum. 1997;69:33-343 [9336729] Med Hypotheses. 1998 Jun;50(6):525-9 [9710329] J Occup Health. 2007 May;49(3):172-82 [17575397] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.9989 ER - TY - JOUR T1 - Embryonic stem cells cultured in serum-free medium acquire bovine apolipoprotein B-100 from feeder cell layers and serum replacement medium. AN - 70206777; 17951218 AB - Previous studies have demonstrated that cell populations that are cultured with heterologous animal products can acquire xenoantigens, potentially limiting their clinical utility because of immune responses. Embryonic stem cells (ESCs) are an attractive source of multiple potential cellular therapies and are typically derived and routinely cultured on murine embryonic fibroblast (MEF) feeder cell layers in commercially available serum replacement (SR) medium or fetal calf serum (FCS)-containing medium. Recently, we found that a strong antibody response was generated in human subjects after the second infusion of therapeutic cells cultured in FCS-containing medium. This response was specific for bovine apolipoprotein B-100 (apoB-100), which is the major protein component of low-density lipoproteins (LDL) and which targets its binding to abundant low-density lipoprotein receptors on the cell surface, from which it is internalized. Here, we have shown that ESCs cultured on MEFs in SR medium acquired bovine apoB-100 from MEFs and from the SR medium as well. Our findings also suggest that bovine LDL are used as critical nutrients for ESC propagation. JF - Stem cells (Dayton, Ohio) AU - Hisamatsu-Sakamoto, Michiko AU - Sakamoto, Norihisa AU - Rosenberg, Amy S AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 72 EP - 78 VL - 26 IS - 1 KW - Antigens, Heterophile KW - 0 KW - Apolipoprotein B-100 KW - Culture Media KW - Index Medicus KW - Microscopy, Confocal KW - Coculture Techniques KW - Animals KW - Blotting, Western KW - Cells, Cultured KW - Immunoprecipitation KW - Mice KW - Flow Cytometry KW - Fibroblasts -- cytology KW - Mice, Transgenic KW - Cell Proliferation KW - Fluorescent Antibody Technique KW - Fibroblasts -- metabolism KW - Antigens, Heterophile -- metabolism KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- cytology KW - Cattle KW - Apolipoprotein B-100 -- immunology KW - Cell Culture Techniques -- methods KW - Antigens, Heterophile -- immunology KW - Culture Media -- adverse effects KW - Apolipoprotein B-100 -- metabolism KW - Culture Media -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70206777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Embryonic+stem+cells+cultured+in+serum-free+medium+acquire+bovine+apolipoprotein+B-100+from+feeder+cell+layers+and+serum+replacement+medium.&rft.au=Hisamatsu-Sakamoto%2C+Michiko%3BSakamoto%2C+Norihisa%3BRosenberg%2C+Amy+S&rft.aulast=Hisamatsu-Sakamoto&rft.aufirst=Michiko&rft.date=2008-01-01&rft.volume=26&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=1549-4918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ultrafine and respirable particles in an automotive grey iron foundry. AN - 70206585; 18056626 AB - Ultrafine particle number and respirable particle mass concentrations were measured throughout an automotive grey iron foundry during winter, spring and summer using a particle concentration mapping procedure. Substantial temporal and spatial variability was observed in all seasons and attributed, in part, to the batch nature of operations, process emission variability and frequent work interruptions. The need for fine mapping grids was demonstrated, where elevations in particle concentrations were highly localized. Ultrafine particle concentrations were generally greatest during winter when incoming make-up air was heated with direct fire, natural gas burners. Make-up air drawn from roof level had elevated respirable mass and ultrafine number concentrations above ambient outdoor levels, suggesting inadvertent recirculation of foundry process emissions. Elevated respirable mass concentrations were highly localized on occasions (e.g. abrasive blasting and grinding), depended on the area within the facility where measurements were obtained, but were largely unaffected by season. Particle sources were further characterized by measuring their respective number and mass concentrations by particle size. Sources that contributed to ultrafine particles included process-specific sources (e.g. melting and pouring operations), and non-process sources (e.g. direct fire natural gas heating units, a liquid propane-fuelled sweeper and cigarette smoking) were additionally identified. JF - The Annals of occupational hygiene AU - Evans, Douglas E AU - Heitbrink, William A AU - Slavin, Thomas J AU - Peters, Thomas M AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 EP - 21 VL - 52 IS - 1 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Inhalation Exposure -- analysis KW - Particle Size KW - Humans KW - Seasons KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70206585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Ultrafine+and+respirable+particles+in+an+automotive+grey+iron+foundry.&rft.au=Evans%2C+Douglas+E%3BHeitbrink%2C+William+A%3BSlavin%2C+Thomas+J%3BPeters%2C+Thomas+M&rft.aulast=Evans&rft.aufirst=Douglas&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of the CATHIA-T sampler, the GK2.69 cyclone and the standard cowled sampler for thoracic fiber concentrations at a Taconite (iron ore)-processing mill. AN - 70205767; 18195326 AB - Several recommendations have been made to the effect that the most appropriate health-based size-selective criterion for fibers is the thoracic convention of the International Organization for Standardization (ISO). The performance of two thoracic samplers, the CATHIA-T (37-mm filter) and the GK2.69 cyclone (37-mm filter), was investigated against the standard 25-mm cowled sampler (current NIOSH 7400 standard method) to determine the effect of thoracic sampling on field results. A total of 270 samples: 80 field and 10 field blank samples for each sampler type, were taken from seven stations in the processing mill of an iron ore mine whose ore contains amphibole minerals. Slides were prepared using the dimethyl formamide/Euparal technique and relocatable cover slips. Two counters examined the slides according to NIOSH 7400 counting A rules with phase contrast microscopes. Prior to counting the sample slides, four reference slides were randomly selected and counted three times on different days to compare the coefficient of variation (CV) between and within counters. Also, seven reference slides were chosen to explore variability between the two microscopes. The average CV between counters (0.148) showed slightly higher than the average CVs within counters (0.072 for Counter 1 and 0.119 for Counter 2). The average CV between the two microscopes was 0.147. Compared to the standard cowled sampler, the overall fiber concentration was lower for the CATHIA-T sampler (CATHIA-T/Cowled = 0.63) and higher for the GK2.69 cyclone (GK2.69/Cowled = 1.66). The result for the CATHIA-T sampler is as expected from laboratory trials, but the result for the GK2.69 cyclone is not as expected. In conclusion, the CATHIA-T sampler has a potential advantage as a high-flow static sampler for screening coarse particles. However, these findings resulted from one field sampling site that contains amphibole minerals, not all of which are asbestiform. Thus, additional field samples from other environments might be helpful to confirm the performance of these samplers. JF - The Annals of occupational hygiene AU - Lee, Eun Gyung AU - Harper, Martin AU - Nelson, John AU - Hintz, Patrick J AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505, USA. elee2@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 55 EP - 62 VL - 52 IS - 1 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Mineral Fibers KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Reproducibility of Results KW - Inhalation Exposure -- analysis KW - Particle Size KW - Humans KW - Mineral Fibers -- analysis KW - Air Pollutants, Occupational -- analysis KW - Metallurgy KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70205767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=A+comparison+of+the+CATHIA-T+sampler%2C+the+GK2.69+cyclone+and+the+standard+cowled+sampler+for+thoracic+fiber+concentrations+at+a+Taconite+%28iron+ore%29-processing+mill.&rft.au=Lee%2C+Eun+Gyung%3BHarper%2C+Martin%3BNelson%2C+John%3BHintz%2C+Patrick+J%3BAndrew%2C+Michael+E&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/10.1093%2Fannhyg%2Fmem062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem062 ER - TY - JOUR T1 - Hearing difficulty attributable to employment by industry and occupation: an analysis of the National Health Interview Survey--United States, 1997 to 2003. AN - 70194997; 18188081 AB - To estimate the national burden of hearing difficulty among workers in US industries and occupations. Data on 130,102 employed National Health Interview Survey respondents between the ages of 18 to 65 years who were interviewed between 1997 and 2003 were analyzed to estimate the population prevalence, adjusted prevalence ratios, and fractions of hearing difficulty attributable to employment. The estimated population prevalence of hearing difficulty was 11.4% (24% attributable to employment). The adjusted prevalence ratios of hearing difficulty were highest for railroads, mining, and primary metal manufacturing industry. Occupations with increased risk of hearing difficulty were mechanics/repairers, machine operators, and transportation equipment operators. Hearing difficulty was differentially distributed across various industries. In industries with high rates, employers and workers should take preventive action to reduce the risk of occupational hearing loss. JF - Journal of occupational and environmental medicine AU - Tak, SangWoo AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. stak@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 46 EP - 56 VL - 50 IS - 1 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Health Surveys KW - Adult KW - Middle Aged KW - Employment KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Industry KW - Occupational Diseases -- epidemiology KW - Occupations KW - Hearing Loss, Sensorineural -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70194997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Hearing+difficulty+attributable+to+employment+by+industry+and+occupation%3A+an+analysis+of+the+National+Health+Interview+Survey--United+States%2C+1997+to+2003.&rft.au=Tak%2C+SangWoo%3BCalvert%2C+Geoffrey+M&rft.aulast=Tak&rft.aufirst=SangWoo&rft.date=2008-01-01&rft.volume=50&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181579316 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-12 N1 - Date created - 2008-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e3181579316 ER - TY - JOUR T1 - NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation. AN - 70182404; 17986233 AB - A novel radioligand, 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine (NIDA522131), for imaging extrathalamic nicotinic acetylcholine receptors (nAChRs) was characterized in vitro and in vivo using positron emission tomography. The K(d) and T(1/2) of dissociation of NIDA522131 binding measured at 37 degrees C in vitro were 4.9 +/- 0.4 pmol/L and 81 +/- 5 min, respectively. The patterns of radioactivity distribution in monkey brain in vivo was similar to that of 2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2FA), a radioligand that has been successfully used in humans, and matched the alpha(4)beta(2)* nAChRs distribution. Comparison between [(18)F]NIDA522131 and 2FA demonstrated better in vivo binding properties of the new radioligand and substantially greater radioactivity accumulation in brain. Consistent with [(18)F]NIDA522131 elevated affinity for nAChRs and its increased lipophilicity, both, the total and non-displaceable distribution volumes were substantially higher than those of 2FA. Estimated binding potential values in different brain regions, characterizing the specificity of receptor binding, were 3-4 fold higher for [(18)F]NIDA522131 than those of 2FA. Pharmacological evaluation in mice demonstrated a toxicity that was comparable to 2FA and is in agreement with a 2300 fold higher affinity at alpha(4)beta(2)* versus alpha(3)beta(4)* nAChRs. These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans. JF - Journal of neurochemistry AU - Chefer, Svetlana I AU - Pavlova, Olga A AU - Zhang, Yi AU - Vaupel, D Bruce AU - Kimes, Alane S AU - Horti, Andrew G AU - Stein, Elliot AU - Mukhin, Alexey G AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 306 EP - 315 VL - 104 IS - 2 KW - 6-chloro-3-((2-azetidinyl)methoxy)-5-(2-fluoropyridin-5-yl)pyridine KW - 0 KW - Azetidines KW - Fluorine Radioisotopes KW - Pyridines KW - Radiopharmaceuticals KW - Receptors, Nicotinic KW - Index Medicus KW - Animals KW - Positron-Emission Tomography -- methods KW - Dose-Response Relationship, Drug KW - Binding, Competitive -- drug effects KW - Mice KW - Autoradiography KW - Rats KW - Evaluation Studies as Topic KW - Behavior, Animal -- drug effects KW - Plasma -- drug effects KW - In Vitro Techniques KW - Macaca mulatta KW - Motor Activity -- drug effects KW - Male KW - Azetidines -- chemistry KW - Thalamus -- diagnostic imaging KW - Pyridines -- chemistry KW - Fluorine Radioisotopes -- pharmacokinetics KW - Radiopharmaceuticals -- pharmacology KW - Radiopharmaceuticals -- chemical synthesis KW - Receptors, Nicotinic -- drug effects KW - Radiopharmaceuticals -- chemistry KW - Azetidines -- pharmacology KW - Pyridines -- pharmacology KW - Fluorine Radioisotopes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70182404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=NIDA522131%2C+a+new+radioligand+for+imaging+extrathalamic+nicotinic+acetylcholine+receptors%3A+in+vitro+and+in+vivo+evaluation.&rft.au=Chefer%2C+Svetlana+I%3BPavlova%2C+Olga+A%3BZhang%2C+Yi%3BVaupel%2C+D+Bruce%3BKimes%2C+Alane+S%3BHorti%2C+Andrew+G%3BStein%2C+Elliot%3BMukhin%2C+Alexey+G&rft.aulast=Chefer&rft.aufirst=Svetlana&rft.date=2008-01-01&rft.volume=104&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving women's health through modernization of our bioinformatics infrastructure. AN - 70167949; 17987048 AB - Our nationwide bioinformatics infrastructure used to detect important sex differences associated with medical product use is antiquated. The Food and Drug Administration (FDA) has embarked on an ambitious bioinformatics modernization effort that will improve our ability to assess the safety and effectiveness of new medical products. This, in turn, will improve our ability to detect important sex differences. JF - Clinical pharmacology and therapeutics AU - Oliva, A AU - Pinnow, E AU - Levin, R AU - Uhl, K AD - Office of Critical Path Programs, Food and Drug Administration, Rockville, Maryland, USA. armando.oliva@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 192 EP - 195 VL - 83 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Consumer Product Safety KW - Sex Factors KW - Humans KW - Information Dissemination KW - Program Development KW - Health Knowledge, Attitudes, Practice KW - Clinical Trials as Topic KW - Patient Selection KW - Male KW - Female KW - Risk Assessment KW - Women's Health KW - Drug-Related Side Effects and Adverse Reactions KW - United States Food and Drug Administration -- organization & administration KW - Computational Biology -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70167949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Improving+women%27s+health+through+modernization+of+our+bioinformatics+infrastructure.&rft.au=Oliva%2C+A%3BPinnow%2C+E%3BLevin%2C+R%3BUhl%2C+K&rft.aulast=Oliva&rft.aufirst=A&rft.date=2008-01-01&rft.volume=83&rft.issue=1&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. AN - 70166527; 17855015 AB - To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score. Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. The first 18 patients received 1 g of amifostine, and the next 12 patients received 2 g. Toxicity was assessed at baseline, during treatment, and at follow-up visits by using RTOG grading and the EPIC Quality of Life (QoL) 50-item questionnaire. The Bowel Function subset of the bowel domain (EPIC-BF), which targets symptom severity, and the Bowel Bother subset of the bowel domain (EPIC-BB), which assesses QoL, were evaluated and compared with the RTOG GI toxicity score. Median follow-up was 30 months (range, 18-36 months). Overall, EPIC-BF and EPIC-BB scores both tracked closely with the RTOG GI toxicity score. Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1-g group (6/18 patients) compared with 0% (0/12 patients) in the 2-g group and tended toward statistical significance (p = 0.06). A significant difference between amifostine groups was observed using the EPIC-BF score at 7 weeks (p = 0.04). A difference in EPIC-BB scores between dose groups was evident at 7 weeks (p = 0.07) and was significant at 12 months (p = 0.04). Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score. JF - International journal of radiation oncology, biology, physics AU - Simone, Nicole L AU - Ménard, Cynthia AU - Soule, Benjamin P AU - Albert, Paul S AU - Guion, Peter AU - Smith, Sharon AU - Godette, Denise AU - Crouse, Nancy S AU - Sciuto, Linda C AU - Cooley-Zgela, Theresa AU - Camphausen, Kevin AU - Coleman, C Norman AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 90 EP - 95 VL - 70 IS - 1 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Severity of Illness Index KW - Dose-Response Relationship, Drug KW - Radiation Injuries -- prevention & control KW - Humans KW - Rectum -- radiation effects KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Administration, Rectal KW - Male KW - Adenocarcinoma -- radiotherapy KW - Radiation-Protective Agents -- administration & dosage KW - Quality of Life KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70166527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+during+external+beam+radiation+therapy+for+prostate+cancer+produces+significant+improvements+in+Quality+of+Life+measured+by+EPIC+score.&rft.au=Simone%2C+Nicole+L%3BM%C3%A9nard%2C+Cynthia%3BSoule%2C+Benjamin+P%3BAlbert%2C+Paul+S%3BGuion%2C+Peter%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+S%3BSciuto%2C+Linda+C%3BCooley-Zgela%2C+Theresa%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BSingh%2C+Anurag+K&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2008-01-01&rft.volume=70&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-07 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):486-93 [15890591] Radiat Res. 1995 Jul;143(1):107-10 [7597137] JAMA. 2005 Sep 14;294(10):1233-9 [16160131] Int J Impot Res. 2006 Jan-Feb;18(1):69-76 [16094413] Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1008-13 [16730138] Strahlenther Onkol. 1999 Nov;175 Suppl 4:27-9 [10584137] Radiother Oncol. 2000 Jan;54(1):11-9 [10719695] J Clin Oncol. 2000 Jun;18(11):2226-33 [10829042] Int J Radiat Oncol Biol Phys. 1978 Jul-Aug;4(7-8):643-7 [213406] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):735-42 [14967428] Urology. 2000 Dec 20;56(6):899-905 [11113727] Radiat Res. 1978 Oct;76(1):172-9 [216048] Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):507-13 [6303992] Radiobiol Radiother (Berl). 1983;24(3):357-64 [6314424] Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):454-61 [12738320] Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1154-60 [12829154] CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36 [11577478] Int J Radiat Oncol Biol Phys. 2001 Nov 15;51(4):988-93 [11704322] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1097-105 [12128107] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1160-4 [12128116] Semin Oncol. 2002 Dec;29(6 Suppl 19):57-60 [12577246] Gastroenterology. 1986 Sep;91(3):644-50 [3015711] Int J Radiat Oncol Biol Phys. 1991 Oct;21(5):1241-6 [1657841] Int J Radiat Oncol Biol Phys. 1992;22(4):799-802 [1312078] Cancer. 1992 Jun 1;69(11):2820-5 [1315211] Cancer. 1994 Oct 15;74(8):2379-84 [7922989] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1316-21 [16029787] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites. AN - 70156521; 18073240 AB - Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the protozoan cell death pathways and the effector molecules involved in such processes remain to be identified. In this report, we describe the pro-apoptotic function of endonuclease G in trypanosomatid parasites. Similar to metazoans, trypanosome endoG showed intrinsic nuclease activity, is localized in mitochondria and is released from this organelle when cell death is triggered. Overexpression of endoG strongly promoted apoptotic cell death under oxidant or differentiation-related stress in Leishmania and, conversely, loss of endoG expression conferred robust resistance to oxidant-induced cell death in T. brucei. These data demonstrate the conservation of the pro-apoptotic endonuclease activity of endoG in these evolutionarily ancient eukaryotic organisms. Furthermore, nuclear DNA degradation by endoG upon release from mitochondria might represent a caspase-independent cell death mechanism in trypanosomatid parasites as genes encoding caspase-like proteins have not been identified in their genomes. JF - Journal of cell science AU - Gannavaram, Sreenivas AU - Vedvyas, Chetan AU - Debrabant, Alain AD - Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda MD 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 99 EP - 109 VL - 121 SN - 0021-9533, 0021-9533 KW - Oxidants KW - 0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Endodeoxyribonucleases KW - EC 3.1.- KW - endonuclease G KW - EC 3.1.21.- KW - Index Medicus KW - Leishmania donovani -- enzymology KW - Animals KW - Trypanosoma brucei brucei -- growth & development KW - Leishmania donovani -- growth & development KW - Humans KW - Mitochondria -- enzymology KW - Macrophages -- parasitology KW - Amino Acid Sequence KW - Leishmania donovani -- genetics KW - Genome, Protozoan KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Sequence Alignment KW - Trypanosoma brucei brucei -- enzymology KW - Oxidants -- toxicity KW - Molecular Sequence Data KW - RNA Interference KW - Fluorescent Antibody Technique KW - Trypanosomatina -- enzymology KW - Apoptosis -- genetics KW - Endodeoxyribonucleases -- chemistry KW - Endodeoxyribonucleases -- isolation & purification KW - Trypanosomatina -- pathogenicity KW - Endodeoxyribonucleases -- genetics KW - Endodeoxyribonucleases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Conservation+of+the+pro-apoptotic+nuclease+activity+of+endonuclease+G+in+unicellular+trypanosomatid+parasites.&rft.au=Gannavaram%2C+Sreenivas%3BVedvyas%2C+Chetan%3BDebrabant%2C+Alain&rft.aulast=Gannavaram&rft.aufirst=Sreenivas&rft.date=2008-01-01&rft.volume=121&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review. AN - 70155875; 18094216 AB - The criterion for assessing whether a drug prolongs QT as described in the International Conference on Harmonization topic E14 guideline does not explicitly account for individual drug concentrations. The authors' experience with reviewing QT studies indicates that understanding the relationship, if any, between individual drug concentration and QT change provides important additional information to support regulatory decision making. Therefore, regulatory reviews of "thorough QT" studies routinely include a characterization of the concentration-QT relationship. The authors provide examples to illustrate how the concentration-QT relationship has been used to plan and interpret the thorough QT study, to evaluate QT risk for drugs that have no thorough QT studies, to assess QT risk in subpopulations, to make dose adjustments, and to write informative drug labels. JF - Journal of clinical pharmacology AU - Garnett, Christine E AU - Beasley, Nhi AU - Bhattaram, V Atul AU - Jadhav, Pravin R AU - Madabushi, Rajanikanth AU - Stockbridge, Norman AU - Tornøe, Christoffer W AU - Wang, Yaning AU - Zhu, Hao AU - Gobburu, Jogarao V AD - Office of Clinical Pharmacology, Center of Drug Evaluation and Reseach, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20903-0002, USA. christine.garnett@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 13 EP - 18 VL - 48 IS - 1 SN - 0091-2700, 0091-2700 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Clinical Trials as Topic KW - Guidelines as Topic KW - Risk Assessment -- methods KW - Arrhythmias, Cardiac -- diagnosis KW - Arrhythmias, Cardiac -- chemically induced KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Drugs, Investigational -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70155875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Concentration-QT+relationships+play+a+key+role+in+the+evaluation+of+proarrhythmic+risk+during+regulatory+review.&rft.au=Garnett%2C+Christine+E%3BBeasley%2C+Nhi%3BBhattaram%2C+V+Atul%3BJadhav%2C+Pravin+R%3BMadabushi%2C+Rajanikanth%3BStockbridge%2C+Norman%3BTorn%C3%B8e%2C+Christoffer+W%3BWang%2C+Yaning%3BZhu%2C+Hao%3BGobburu%2C+Jogarao+V&rft.aulast=Garnett&rft.aufirst=Christine&rft.date=2008-01-01&rft.volume=48&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-18 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Pharmacol. 2008 Jan;48(1):9-12 [18094215] J Clin Pharmacol. 2008 Jan;48(1):6-8 [18094214] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay. AN - 70147226; 17707568 AB - The Brazilian mushroom Agaricus blazei Murill has antimutagenic, antioxidant, immunostimulatory and antitumorigenic activities, and is increasingly consumed as a health food worldwide. We undertook the present study to evaluate the chronic toxicity and oncogenicity of A. blazei Murill in F344 rats. To establish a no-observed-adverse-effect level (NOAEL), four treatment groups of 100 rats each (50 males and 50 females) were fed a powder diet containing lyophilized A. blazei aqueous extract at 0, 6250, 12,500, and 25,000 ppm for up to 2 years. During this period, there was no remarkable change in mean body weight, body weight gain, hematologic or serum chemistry parameters, or absolute or relative organ weights in control or treatment groups. Mortality in male treatment groups (26%, 16%, and 30%), however, was significantly lower than in controls (48%). Histopathological studies showed no increased incidence of tumors in any treatment group, and total tumor incidence across all groups was comparable to historical data. In conclusion, an A. blazei Murill lyophilized powder diet even at 25,000 ppm (1176 mg/kgb x w x /day for male rats and 1518 mg/kgb.w./day for female rats) resulted in no remarkable carcinogenic effects in F344 rats over a 2-year period. Therefore, the dietary NOAEL is 25,000 ppm. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Lee, I P AU - Kang, B H AU - Roh, J K AU - Kim, J R AD - Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Republic of Korea. iplee0823@aol.com Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 87 EP - 95 VL - 46 IS - 1 SN - 0278-6915, 0278-6915 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Sex Characteristics KW - Freeze Drying KW - Eye Diseases -- chemically induced KW - Organ Size KW - Blood Cell Count KW - Rats KW - Eating KW - Rats, Inbred F344 KW - No-Observed-Adverse-Effect Level KW - Neoplasms -- pathology KW - Body Weight -- drug effects KW - Neoplasms -- chemically induced KW - Carcinogenicity Tests KW - Eye Diseases -- pathology KW - Diet KW - Female KW - Male KW - Agaricales -- chemistry KW - Carcinogens -- chemistry KW - Carcinogens -- toxicity KW - Agaricus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70147226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Lack+of+carcinogenicity+of+lyophilized+Agaricus+blazei+Murill+in+a+F344+rat+two+year+bioassay.&rft.au=Lee%2C+I+P%3BKang%2C+B+H%3BRoh%2C+J+K%3BKim%2C+J+R&rft.aulast=Lee&rft.aufirst=I&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing total fungal concentrations on commercial passenger aircraft using mixed-effects modeling. AN - 70089826; 18041644 AB - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n = 12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value < 0.0001) and inside the aircraft (p-value < 0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak. JF - Journal of occupational and environmental hygiene AU - McKernan, Lauralynn Taylor AU - Hein, Misty J AU - Wallingford, Kenneth M AU - Burge, Harriet AU - Herrick, Robert AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45226, USA. lmckernan@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 48 EP - 58 VL - 5 IS - 1 SN - 1545-9624, 1545-9624 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Air Pollution, Indoor -- analysis KW - Colony Count, Microbial KW - Models, Statistical KW - Environmental Monitoring -- statistics & numerical data KW - Aircraft KW - Air Pollutants -- isolation & purification KW - Fungi -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70089826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Assessing+total+fungal+concentrations+on+commercial+passenger+aircraft+using+mixed-effects+modeling.&rft.au=McKernan%2C+Lauralynn+Taylor%3BHein%2C+Misty+J%3BWallingford%2C+Kenneth+M%3BBurge%2C+Harriet%3BHerrick%2C+Robert&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-01-01&rft.volume=5&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of asthma among youth on Hispanic-operated farms in the United States-2000. AN - 69877518; 19064420 AB - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p p > .05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p p < .05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations. JF - Journal of agromedicine AU - Syamlal, Girija AU - Mazurek, Jacek M AD - Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morganton, West Virginia, USA. gos2@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 155 EP - 164 VL - 13 IS - 3 SN - 1059-924X, 1059-924X KW - Index Medicus KW - Occupational Exposure KW - Young Adult KW - Occupational Health KW - Age Factors KW - Sex Factors KW - Humans KW - Infant, Newborn KW - Child KW - Child, Preschool KW - Infant KW - Off-Road Motor Vehicles KW - Risk Factors KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Agriculture KW - Asthma -- epidemiology KW - Hispanic Americans -- statistics & numerical data KW - Asthma -- ethnology KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- ethnology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69877518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Prevalence+of+asthma+among+youth+on+Hispanic-operated+farms+in+the+United+States-2000.&rft.au=Syamlal%2C+Girija%3BMazurek%2C+Jacek+M&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2008-01-01&rft.volume=13&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240802397875 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10599240802397875 ER - TY - JOUR T1 - Safety alert for fentanyl buccal tablets. AN - 69874373; 19062355 AB - On September 13, 2007, the United States Food and Drug Administration posted a safety alert for fentanyl buccal tablets (Fentora). The announcement and hyperlinks to the Dear Doctor and Dear Healthcare Professional Letters that were distributed by the sponsor are presented. JF - Journal of pain & palliative care pharmacotherapy AU - U.S. Food and Drug Administration AD - U.S. Food and Drug Administration Y1 - 2008 PY - 2008 DA - 2008 SP - 47 VL - 22 IS - 1 KW - Analgesics, Opioid KW - 0 KW - Tablets KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - United States KW - Pain -- etiology KW - Pain -- drug therapy KW - United States Food and Drug Administration KW - Neoplasms -- complications KW - Humans KW - Administration, Buccal KW - Palliative Care KW - Respiratory Insufficiency -- chemically induced KW - Adverse Drug Reaction Reporting Systems KW - Fentanyl -- adverse effects KW - Analgesics, Opioid -- therapeutic use KW - Fentanyl -- therapeutic use KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Fentanyl -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69874373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Safety+alert+for+fentanyl+buccal+tablets.&rft.au=U.S.+Food+and+Drug+Administration&rft.aulast=U.S.+Food+and+Drug+Administration&rft.aufirst=&rft.date=2008-01-01&rft.volume=22&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=1536-0539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Marijuana neurobiology and treatment. AN - 69849778; 19042204 AB - Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for marijuana dependence based on a pre-meeting workshop that was presented at ISAM 2006. At the workshop, several papers were presented addressing the neurobiology and pharmacology of marijuana and treatment approaches, both psychotherapy and medications, for marijuana withdrawal. Medicolegal and ethical issues concerning marijuana medical use were also discussed. Concise summaries of these presentations are incorporated in this article, which is meant to be an updated review of the state of the science. Major advances have been made in understanding the underpinning of marijuana dependence and the role of the CNS cannabinoid system, which is a major area for targeting medications to treat marijuana withdrawal and dependence, as well as other addictions. Behavioral therapies are efficacious for facilitating abstinence from marijuana. Nefazadone, Marinol, and buspirone are showing early positive signals for efficacy in ameliorating marijuana withdrawal symptoms. Effective psychotherapeutic approaches are available and promising medications studies need to be confirmed in outpatient trials. The next few years looking promising for translational research efforts to make treatment widely accessible to patients with marijuana dependence. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Huestis, Marilyn AU - Haney, Margaret AU - Budney, Alan AU - Gruber, Amanda AU - el-Guebaly, Nady AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 17 EP - 29 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Narcotic Antagonists KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Dronabinol KW - 7J8897W37S KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Cognitive Therapy KW - Humans KW - Social Facilitation KW - Dronabinol -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buspirone -- therapeutic use KW - Marijuana Abuse -- rehabilitation KW - Brain -- drug effects KW - Marijuana Abuse -- therapy KW - Triazoles -- therapeutic use KW - Cannabis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69849778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Marijuana+neurobiology+and+treatment.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHuestis%2C+Marilyn%3BHaney%2C+Margaret%3BBudney%2C+Alan%3BGruber%2C+Amanda%3Bel-Guebaly%2C+Nady&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] Am J Addict. 2004 Jan-Feb;13(1):21-32 [14766435] J Subst Abuse Treat. 2004 Oct;27(3):195-6 [15501372] J Subst Abuse Treat. 2004 Oct;27(3):197-213 [15501373] Am J Psychiatry. 2004 Nov;161(11):1967-77 [15514394] Psychopharmacology (Berl). 1981;74(3):208-12 [6267648] J Pharmacol Exp Ther. 1986 Nov;239(2):311-9 [3021952] Int J Addict. 1987 Jul;22(7):639-51 [3497886] Nature. 1990 Aug 9;346(6284):561-4 [2165569] J Anal Toxicol. 1992 Sep-Oct;16(5):302-6 [1338218] J Consult Clin Psychol. 1993 Dec;61(6):1100-4 [8113490] Arch Gen Psychiatry. 1994 Jul;51(7):568-76 [8031230] J Consult Clin Psychol. 1994 Feb;62(1):92-9 [8034835] Drug Alcohol Depend. 1995 Nov;40(1):9-15 [8746919] Psychopharmacology (Berl). 1999 Feb;141(4):395-404 [10090647] Addict Behav. 1999 Jan-Feb;24(1):111-4 [10189977] Psychopharmacology (Berl). 1999 Apr;143(3):302-8 [10353434] J Am Acad Child Adolesc Psychiatry. 2005 Jun;44(6):513-21 [15908833] Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646] J Consult Clin Psychol. 2006 Feb;74(1):42-54 [16551142] J Consult Clin Psychol. 2006 Apr;74(2):307-16 [16649875] Am J Addict. 2006 Sep-Oct;15(5):404 [16966201] Addict Behav. 2007 Jun;32(6):1220-36 [16996224] Neuropsychopharmacology. 2007 Jun;32(6):1391-403 [17091128] Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 [17481828] Drug Alcohol Depend. 2005 Jul;79(1):11-22 [15943940] Curr Psychiatry Rep. 2005 Oct;7(5):360-6 [16216154] Addiction. 1999 Sep;94(9):1311-22 [10615717] Ann Emerg Med. 2000 Apr;35(4):398-9 [10736129] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] J Consult Clin Psychol. 2000 Oct;68(5):898-908 [11068976] J Consult Clin Psychol. 2000 Dec;68(6):1051-61 [11142539] Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091] Psychopharmacology (Berl). 2001 May;155(2):171-9 [11401006] J Subst Abuse Treat. 2001 Sep;21(2):55-64; discussion 65-6 [11551733] Arch Gen Psychiatry. 2001 Oct;58(10):909-15 [11576028] Arch Gen Psychiatry. 2001 Oct;58(10):917-24 [11576029] Nat Med. 2001 Oct;7(10):1151-4 [11590440] J Consult Clin Psychol. 2001 Oct;69(5):802-13 [11680557] Am J Drug Alcohol Abuse. 2001 Nov;27(4):651-88 [11727882] J Neurosci. 2001 Dec 15;21(24):9867-76 [11739594] Neuropsychopharmacology. 2002 Apr;26(4):479-88 [11927172] Drug Alcohol Depend. 2002 Aug 1;67(3):301-9 [12127201] Psychopharmacology (Berl). 2002 Dec;164(4):407-15 [12457271] Psychopharmacology (Berl). 2003 Jan;165(2):157-65 [12439626] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1393-8 [12538878] J Subst Abuse Treat. 2003 Jun;24(4):369-76 [12867212] J Int Neuropsychol Soc. 2003 Jul;9(5):679-89 [12901774] J Abnorm Psychol. 2003 Aug;112(3):393-402 [12943018] J Subst Abuse Treat. 2003 Sep;25(2):85-9 [14629990] Psychol Med. 2003 Nov;33(8):1415-22 [14672250] Neuropsychopharmacology. 2004 Jan;29(1):158-70 [14560320] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63 [15363608] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218166 ER - TY - JOUR T1 - Pharmacotherapy of methamphetamine addiction: an update. AN - 69839698; 19042205 AB - Methamphetamine dependence is a serious public health problem worldwide for which there are no approved pharmacological treatments. Psychotherapy is still the mainstay of treatment; however, relapse rates are high. The search for effective pharmacological treatment has intensified in the last decade. This review will highlight progress in pharmacological interventions to treat methamphetamine dependence as well as explore new pharmacological targets. Published data from clinical trials for stimulant addiction were searched using PubMed and summarized, as well as highlights from a recent symposium on methamphetamine pharmacotherapy presented at the ISAM 2006 meeting, including interim analysis data from an ongoing D-amphetamine study in Australia. Early pilot data are encouraging for administering D-amphetamine and methylphenidate as treatment for heavy amphetamine users. Abilify at 15 mg/day dose increased amphetamine use in an outpatient pilot study. Sertraline, ondansetron, baclofen, tyrosine, and imipramine were ineffective in proof-of-concept studies. Development of pharmacotherapy for methamphetamine dependence is still in an early stage. Data suggesting D-amphetamine and methylphenidate as effective pharmacotherapy for methamphetamine addiction will need to be confirmed by larger trials. Preclinical data suggest that use of GVG, CB1 antagonist, and lobeline are also promising therapeutic strategies. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Hanson, Glen AU - White, Jason AU - Wickes, Wendy AU - Tiihonen, Jari AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 31 EP - 49 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Antipsychotic Agents KW - 0 KW - Central Nervous System Stimulants KW - Narcotic Antagonists KW - Nicotinic Agonists KW - Piperazines KW - Quinolones KW - Bupropion KW - 01ZG3TPX31 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Aripiprazole KW - 82VFR53I78 KW - Lobeline KW - D0P25S3P81 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Dextroamphetamine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Quinolones -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Bupropion -- therapeutic use KW - Piperazines -- therapeutic use KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Methylphenidate -- therapeutic use KW - Lobeline -- therapeutic use KW - Recurrence KW - Prevalence KW - Drug Therapy -- methods KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Pharmacotherapy+of+methamphetamine+addiction%3A+an+update.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHanson%2C+Glen%3BWhite%2C+Jason%3BWickes%2C+Wendy%3BTiihonen%2C+Jari&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218554 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 2001 Jul;41(1):22-8 [11354010] Pharmacol Rev. 2001 Jun;53(2):209-43 [11356984] J Pharmacol Exp Ther. 2001 Jul;298(1):172-9 [11408539] Nat Neurosci. 2001 Sep;4(9):873-4 [11528416] Addiction. 2001 Sep;96(9):1289-96 [11672493] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] J Neurosci. 2000 Aug 1;20(15):RC89 [10899176] Cochrane Database Syst Rev. 2002;(2):CD002025 [12076434] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11452-7 [12154229] J Neurochem. 2002 Sep;82(5):1171-8 [12358764] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Neuropsychopharmacology. 2003 Feb;28(2):329-38 [12589386] Synapse. 2003 Jun 1;48(3):154-6 [12645041] Mol Psychiatry. 2003 Apr;8(4):373-82 [12740594] Physiol Behav. 2003 Jun;79(1):121-8 [12818717] Neuropsychopharmacology. 2003 Jul;28(7):1272-80 [12700694] J Neurosci Res. 2003 Oct 1;74(1):91-6 [13130510] Ann N Y Acad Sci. 2003 Nov;1003:415-8 [14684476] Am J Psychiatry. 2004 Feb;161(2):242-8 [14754772] Psychopharmacology (Berl). 2004 Mar;172(2):170-8 [14624331] Alcohol Clin Exp Res. 2004 Apr;28(4):558-65 [15100606] Trends Pharmacol Sci. 2004 May;25(5):265-72 [15120493] J Neurosci. 2004 May 19;24(20):4723-7 [15152032] Am J Addict. 2004 May-Jun;13(3):248-55 [15370944] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Med J Aust. 1990 Sep 3;153(5):306 [2392087] Nature. 1990 Sep 13;347(6289):146-51 [1975644] NIDA Res Monogr. 1991;115:84-98 [1758486] Br J Addict. 1992 Mar;87(3):439-46 [1559042] Addiction. 1994 Jan;89(1):79-85 [8148747] Acta Psychiatr Scand. 1994 Jun;89(6):428-32 [8085475] J R Soc Health. 1994 Jun;114(3):127-31 [7932481] Eur J Pharmacol. 1995 Aug 4;281(2):R7-9 [7589197] J Pharmacol Exp Ther. 1996 Sep;278(3):1128-37 [8819495] J Neurosci. 1997 Apr 1;17(7):2605-14 [9065520] Synapse. 1997 Apr;25(4):393-8 [9097399] Mol Psychiatry. 1997 Jan;2(1):5-6 [9154208] J Subst Abuse Treat. 1996 Nov-Dec;13(6):493-7 [9219147] Neuroreport. 1997 Jul 7;8(9-10):2373-7 [9243643] Pediatrics. 1997 Oct;100(4):662-6 [9310521] J Pharmacol Exp Ther. 1997 Oct;283(1):7-15 [9336302] Drug Alcohol Depend. 1997 Nov 25;48(2):113-8 [9363410] Psychopharmacology (Berl). 1998 May;137(2):184-90 [9630005] J Neurosci. 1998 Jul 15;18(14):5529-36 [9651233] Drug Alcohol Depend. 1998 Sep 1;52(1):79-84 [9788010] Nature. 1999 Jul 22;400(6742):371-5 [10432116] Aust N Z J Psychiatry. 1999 Aug;33(4):494-502 [10483843] J Clin Psychopharmacol. 2004 Dec;24(6):665-9 [15538132] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Mar;178(2-3):296-302 [15452681] Neuron. 2005 Mar 3;45(5):647-50 [15748840] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Int J Neuropsychopharmacol. 2005 Jun;8(2):203-13 [15850499] Synapse. 2005 Jul;57(1):17-28 [15858839] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Am J Hypertens. 2005 Jun;18(6):813-22 [15925741] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Behav Pharmacol. 2005 Sep;16(5-6):275-96 [16148435] Nature. 2005 Sep 22;437(7058):556-9 [16100511] Psychopharmacology (Berl). 2005 Nov;182(3):426-35 [16163531] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73 [16357203] Pharmacol Biochem Behav. 2005 Dec;82(4):704-11 [16413604] Drug Alcohol Depend. 2006 Oct 15;85(1):12-8 [16621339] Drug Alcohol Depend. 2006 Dec 1;85(3):177-84 [16740370] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):123-30 [16978753] Am J Psychiatry. 2007 Jan;164(1):160-2 [17202560] Int J Neuropsychopharmacol. 2007 Feb;10(1):85-98 [16448579] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):455-61 [17184890] Synapse. 2005 Feb;55(2):122-5 [15543630] Mol Pharmacol. 2005 Feb;67(2):349-55 [15548766] Ann N Y Acad Sci. 1999;897:27-45 [10676433] Addiction. 2000 Feb;95(2):229-38 [10723851] J Psychiatry Neurosci. 2000 Mar;25(2):125-36 [10740986] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Ann N Y Acad Sci. 2000;909:260-3 [10911936] Psychopharmacology (Berl). 2000 Jun;150(3):317-24 [10923760] Am J Addict. 2000 Summer;9(3):222-31 [11000918] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218554 ER - TY - JOUR T1 - Long-term consequences of drugs on the paediatric cardiovascular system. AN - 69819328; 19026026 AB - Many pharmacological and toxicological actions of drugs in children cannot be fully predicted from adult clinical experience or from standard non-clinical toxicology studies. Numerous drugs have direct or indirect pharmacological effects on the heart and are prescribed for children of all ages. Toxicity or secondary effects may be immediate or delayed for years after drug exposure has ceased. Originally, the aim of this review was to compile information on the effect of specific drugs on the post-natal development of the cardiovascular system and to examine long-term follow-up of the use of cardio-active drugs in children. The limited database of published information caused the original question to evolve into an examination of the medical literature for three areas of information: (i) whether vulnerable developmental windows have been identified that reflect the substantial functional development that the cardiovascular system undergoes after birth; (ii) what is known about pharmacological perturbation of development; and (iii) what the likelihood is of drug exposure during childhood. We examined different scenarios for exposure including random, isolated exposure, conditions historically associated with adults, primary or secondary cardiac disease, psychiatric and neurological conditions, asthma, cancer and HIV. Except for random, isolated drug exposures, each category of possible exposure contained numerous drugs known to have either primary or secondary effects on the cardiovascular system or to influence factors associated with atherosclerosis. It is likely that a significant number of children will be prescribed drugs having either direct or indirect effects upon the immature cardiovascular system. A confounding factor is the simultaneous use of over-the-counter medications and herbal or nutraceutical preparations that a patient, parent or guardian does not mention to a prescribing physician. Metabolism is also important in assessing drug effects in children. Differences in body water : body fat ratio, age-related gastrointestinal absorption, distribution, excretion, renal function and drug metabolizing capabilities make it possible for children to have a different metabolite profile for a drug compared with adults. There is little examination of drug effects on the interdependent processes of cardiac maturation and less examination of metabolite effects. It is difficult to identify delayed toxicities in children as these adverse events may take years to manifest with many patients lost to follow-up. Clearly this is an area of study where intermediate endpoints and surrogate markers would be of great benefit. Pharmacogenomics may be useful in providing markers of increased risk or susceptibility. A perspective must be kept in balancing the possibility of a problem with the very real benefits that many children experience from the use of these pharmaceuticals. JF - Drug safety AU - Hausner, Elizabeth AU - Fiszman, Monica L AU - Hanig, Joseph AU - Harlow, Patricia AU - Zornberg, Gwen AU - Sobel, Solomon AD - Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1083 EP - 1096 VL - 31 IS - 12 SN - 0114-5916, 0114-5916 KW - Anti-Asthmatic Agents KW - 0 KW - Anti-HIV Agents KW - Anticonvulsants KW - Antineoplastic Agents KW - Glucocorticoids KW - Nonprescription Drugs KW - Prescription Drugs KW - Psychotropic Drugs KW - Index Medicus KW - Age Factors KW - Biomedical Research -- organization & administration KW - Humans KW - Anti-HIV Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Complementary Therapies -- adverse effects KW - Child KW - Glucocorticoids -- adverse effects KW - Psychotropic Drugs -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Nonprescription Drugs -- adverse effects KW - Polypharmacy KW - Clinical Trials as Topic -- legislation & jurisprudence KW - Prescription Drugs -- adverse effects KW - Pediatrics KW - Child Development -- drug effects KW - Cardiovascular System -- drug effects KW - Prescription Drugs -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Long-term+consequences+of+drugs+on+the+paediatric+cardiovascular+system.&rft.au=Hausner%2C+Elizabeth%3BFiszman%2C+Monica+L%3BHanig%2C+Joseph%3BHarlow%2C+Patricia%3BZornberg%2C+Gwen%3BSobel%2C+Solomon&rft.aulast=Hausner&rft.aufirst=Elizabeth&rft.date=2008-01-01&rft.volume=31&rft.issue=12&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/10.2165%2F0002018-200831120-00005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2165/0002018-200831120-00005 ER - TY - JOUR T1 - Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) users. AN - 69803732; 18855243 AB - 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers. JF - The American journal of drug and alcohol abuse AU - Kanneganti, Praveen AU - Huestis, Marilyn A AU - Kolbrich, Erin A AU - Goodwin, Robert AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 712 EP - 720 VL - 34 IS - 6 KW - Hallucinogens KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Young Adult KW - Sex Factors KW - Humans KW - Adult KW - Marijuana Abuse -- physiopathology KW - Male KW - Female KW - Prevalence KW - Electrocardiography -- methods KW - Arrhythmias, Cardiac -- diagnosis KW - N-Methyl-3,4-methylenedioxyamphetamine -- adverse effects KW - Arrhythmias, Cardiac -- etiology KW - Hallucinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69803732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Signal-averaged+electrocardiogram+in+physically+healthy%2C+chronic+3%2C4-methylenedioxymethamphetamine+%28MDMA%29+users.&rft.au=Kanneganti%2C+Praveen%3BHuestis%2C+Marilyn+A%3BKolbrich%2C+Erin+A%3BGoodwin%2C+Robert%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-01-01&rft.volume=34&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=1097-9891&rft_id=info:doi/10.1080%2F00952990802308254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacol Ther. 1971 Sep-Oct;12(5):762-8 [4936140] Ann Emerg Med. 2003 Sep;42(3):365-9 [12944889] N Engl J Med. 1987 Oct 22;317(17):1098 [3657876] Am J Forensic Med Pathol. 1988 Dec;9(4):339-41 [3239555] Acta Cardiol. 1992;47(5):435-43 [1441851] Pacing Clin Electrophysiol. 1994 Mar;17(3 Pt 1):303-11 [7513855] Pacing Clin Electrophysiol. 1994 Mar;17(3 Pt 2):446-50 [7513872] Br Heart J. 1994 Aug;72(2):197-200 [7917698] J Am Coll Cardiol. 1996 Jan;27(1):238-49 [8522703] J Clin Pathol. 1996 Feb;49(2):149-53 [8655682] J Pharmacol Exp Ther. 1999 Jul;290(1):136-45 [10381769] Emerg Med J. 2005 Sep;22(9):679-80 [16113206] Int J Cardiol. 2005 Sep 30;104(2):230-2 [16168820] Fundam Clin Pharmacol. 2006 Feb;20(1):1-8 [16448390] Int J Cardiol. 2007 May 31;118(2):141-4 [17005273] Am J Cardiol. 1990 Dec 1;66(19):1359-62 [2244568] Prog Cardiovasc Dis. 1992 Nov-Dec;35(3):169-88 [1438789] Obes Res. 2000 Jan;8(1):20-8 [10678255] Heart. 2000 Jun;83(6):627-33 [10814617] Ann Intern Med. 2000 Dec 19;133(12):969-73 [11119398] CMAJ. 2001 Oct 2;165(7):917-28 [11599334] Curr Womens Health Rep. 2002 Apr;2(2):83-8 [12116606] J Pharmacol Exp Ther. 2002 Sep;302(3):898-907 [12183645] J Clin Pharmacol. 2002 Nov;42(11 Suppl):58S-63S [12412837] JAMA. 1987 Mar 27;257(12):1615-7 [2881002] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00952990802308254 ER - TY - JOUR T1 - Expanding the role of health services research as a tool to reduce the public health burden of alcohol use disorders. AN - 69803239; 19016162 AB - The public and private cost of "heavy alcohol use" is estimated to be more than 187 billion in lost productivity, health care and criminal justice expenditures, and other costs. This does not include the emotional and psychological costs to family, friends, and the community. Investments by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have led to a number of important advances in pharmacological and behavioral treatments for alcohol disorders. Yet, there continues to be a significant gap between research findings and progress in community-based care. Additionally, limited capacity, a lack of acknowledged standards, and a separation between the specialty substance use treatment sector and general medical practice contribute to this gap. As part of its ongoing efforts to encourage translation from clinical research to practice, NIAAA undertook a review of its alcohol related health services research program for the purpose of creating a vision for the next 10 yr that is sensitive to the changing needs of both the clinical and research communities. Central to the development of a new research agenda is a reconceptualization of alcohol use and misuse along a continuum that takes into account quantity and frequency of use as well as the consequences from "heavy use" and misuse of alcohol. This public health approach recommends a number of high priority areas to expand and improve the system of care for "heavy alcohol users" who may be at-risk or who may have developed an alcohol use disorder. These recommendations include research on dissemination and implementation of evidence-based practices, and improving access and utilization to care for individuals who are "heavy users." The paper concludes by outlining some of the steps taken by NIAAA to further the continuing development of alcohol health services research. JF - Substance use & misuse AU - Delany, Peter J AU - Shields, Joseph J AU - Willenbring, Mark L AU - Huebner, Robert B AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland 20857, USA. Peter.Delany@samhsa.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1729 EP - 1746 VL - 43 IS - 12-13 KW - Index Medicus KW - Humans KW - Recurrence KW - Health Services Accessibility KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcoholism -- diagnosis KW - Health Services Research -- economics KW - Alcoholism -- therapy KW - Role KW - Alcoholism -- economics KW - Alcoholism -- complications KW - Public Health -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69803239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+use+%26+misuse&rft.atitle=Expanding+the+role+of+health+services+research+as+a+tool+to+reduce+the+public+health+burden+of+alcohol+use+disorders.&rft.au=Delany%2C+Peter+J%3BShields%2C+Joseph+J%3BWillenbring%2C+Mark+L%3BHuebner%2C+Robert+B&rft.aulast=Delany&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=43&rft.issue=12-13&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=Substance+use+%26+misuse&rft.issn=1532-2491&rft_id=info:doi/10.1080%2F10826080802345341 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-17 N1 - Date created - 2008-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10826080802345341 ER - TY - JOUR T1 - Ergonomics interventions at Badger Mining Corporation. AN - 69720219; 18954545 AB - In 2005, the National Institute for Occupational Safety and Health (NIOSH) and Badger Mining Corporation entered a partnership to implement ergonomics interventions, including a systematic process, to address exposure to risk factors that may result in musculoskeletal disorders or other types of injuries/illnesses. As a result of this partnership, an ergonomics process was integrated with the existing safety and health programme to promote an on-going application of ergonomics principles, and over 40 task-specific interventions were implemented during the first year of the process. This paper presents details of the process integration, and several examples of task-specific interventions that reduced exposure to risk factors. JF - International journal of occupational safety and ergonomics : JOSE AU - Torma-Krajewski, Janet AD - National Institute for Occupational Safety and Health (NIOSH), Pittsburgh, PA, USA. jtorma@mines.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 351 EP - 359 VL - 14 IS - 3 SN - 1080-3548, 1080-3548 KW - Index Medicus KW - Musculoskeletal Diseases -- prevention & control KW - Humans KW - Occupational Diseases -- prevention & control KW - Program Development KW - Wisconsin KW - Occupational Health KW - Task Performance and Analysis KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69720219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.atitle=Ergonomics+interventions+at+Badger+Mining+Corporation.&rft.au=Torma-Krajewski%2C+Janet&rft.aulast=Torma-Krajewski&rft.aufirst=Janet&rft.date=2008-01-01&rft.volume=14&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.issn=10803548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of false positive rates of peto and poly-3 methods for long-term carcinogenicity data analysis using multiple comparison adjustment method suggested by Lin and Rahman. AN - 69536085; 18781527 AB - Statistical analyses of two-year carcinogenicity data include tests for dose-response relationship (positive trend) among the increasing doses and pairwise comparisons of treated groups with control in tumor incidence by organ/tumor combination. There are two major concerns in analyzing carcinogenicity data, namely, adjustment for the difference in mortality due to drug toxicity and adjustment for the multiplicity due to multiple testing of trends and pairwise differences by organ tumor combination. A widely used method for testing dose-response relationship is the method suggested by Peto et al. (Peto test). The Peto test adjusts the mortality differences among treatment groups by partitioning the entire study period into several intervals, analyzing the data separately for each interval, and then combining them using the Mantel-Haenszel procedure. The denominator for the calculation of the proportion of tumor bearing animals is determined from the cause of death information tumor data. In later works, researchers have expressed concerns regarding the construction of suitable intervals for mortality adjustment. Also according to the opinion of many pathologists it is difficult to accurately specify retrospectively if a tumor is the real cause of death of an animal. This information may be imprecise. Hence, many times results of analysis using the Peto test are questioned due to the inaccurate cause of death information. An alternative to the Peto test was suggested by Bailer and Portier, popularly known as Poly-K test. Unlike the Peto test, this test does not need any arbitrary partitioning of the study period or the cause of death information. This test for trend in tumor incidence adjusts the differences in mortality among treatment groups by assigning a weight of less than one to an animal that died early without developing the tumor; and a weight of one to an animal that died with the tumor or survived to the end of the study. The sum of the assigned weights of animals in a treatment group is then used as the denominator for the calculation of proportion of tumor-bearing animals for the group. The less-than-one weight assigned to an animal is the fraction of the animal's surviving time in the study over the maximum time of the study with a power k. The power k of the fraction is determined by the distribution of tumor onset times of the tumor. The Poly-K test may have some advantages over the Peto test in the sense that it does not require the cause of death information, which is an essential part for the Peto test. However, the performance of the Poly-K test in controlling the false positive rate in comparison to the Peto test is unknown and of great interest in the regulatory environment. In this work the authors compared the overall false positive rates of the Peto and Poly-K tests using the Lin-Rahman multiple comparison adjustment based on some simulation results. JF - Journal of biopharmaceutical statistics AU - Rahman, Mohammad A AU - Lin, Karl K AD - Division of Biometrics 6, Office of Biostatistics/Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. mohammad.rahman@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 949 EP - 958 VL - 18 IS - 5 KW - Index Medicus KW - Animals KW - Neoplasms, Experimental -- chemically induced KW - Dose-Response Relationship, Drug KW - Neoplasms, Experimental -- mortality KW - Carcinogenicity Tests -- methods KW - Data Interpretation, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69536085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=A+comparison+of+false+positive+rates+of+peto+and+poly-3+methods+for+long-term+carcinogenicity+data+analysis+using+multiple+comparison+adjustment+method+suggested+by+Lin+and+Rahman.&rft.au=Rahman%2C+Mohammad+A%3BLin%2C+Karl+K&rft.aulast=Rahman&rft.aufirst=Mohammad&rft.date=2008-01-01&rft.volume=18&rft.issue=5&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802287628 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802287628 ER - TY - JOUR T1 - Identifying high-dimensional biomarkers for personalized medicine via variable importance ranking. AN - 69534717; 18781521 AB - We apply robust classification algorithms to high-dimensional genomic data to find biomarkers, by analyzing variable importance, that enable a better diagnosis of disease, an earlier intervention, or a more effective assignment of therapies. The goal is to use variable importance ranking to isolate a set of important genes that can be used to classify life-threatening diseases with respect to prognosis or type to maximize efficacy or minimize toxicity in personalized treatment of such diseases. A ranking method and present several other methods to select a set of important genes to use as genomic biomarkers is proposed, and the performance of the selection procedures in patient classification by cross-validation is evaluated. The various selection algorithms are applied to published high-dimensional genomic data sets using several well-known classification methods. For each data set, a set of genes selected on the basis of variable importance that performed the best in classification is reported. That classification algorithm with the proposed ranking method is shown to be competitive with other selection methods for discovering genomic biomarkers underlying both adverse and efficacious outcomes for improving individualized treatment of patients for life-threatening diseases. JF - Journal of biopharmaceutical statistics AU - Baek, Songjoon AU - Moon, Hojin AU - Ahn, Hongshik AU - Kodell, Ralph L AU - Lin, Chien-Ju AU - Chen, James J AD - Division of Personalized Nutrition and Medicine-Biometry Branch, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 853 EP - 868 VL - 18 IS - 5 KW - Biomarkers KW - 0 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Leukemia, Myeloid, Acute -- mortality KW - Lymphoma -- classification KW - Lymphoma -- genetics KW - Leukemia, Myeloid, Acute -- genetics KW - Algorithms KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69534717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Identifying+high-dimensional+biomarkers+for+personalized+medicine+via+variable+importance+ranking.&rft.au=Baek%2C+Songjoon%3BMoon%2C+Hojin%3BAhn%2C+Hongshik%3BKodell%2C+Ralph+L%3BLin%2C+Chien-Ju%3BChen%2C+James+J&rft.aulast=Baek&rft.aufirst=Songjoon&rft.date=2008-01-01&rft.volume=18&rft.issue=5&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802278023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802278023 ER - TY - JOUR T1 - Effects of stratification on data mining in the US Vaccine Adverse Event Reporting System (VAERS). AN - 69321946; 18636785 AB - Vaccines are administered differentially according to age and sex, and disease patterns also vary among people of different age and sex groups. Estimates of disproportionality should be calculated based on comparisons of groups that have a similar likelihood of receiving similar vaccines and experiencing similar adverse events, to prevent false disproportionality from occurring. Stratified empirical Bayesian (EB) methods have been compared with crude, but not stratified, proportional reporting ratios (PRRs) in their performance on adverse event data. (i) to implement stratification of PRR; (ii) to quantify and compare vaccine-event pairs that are highlighted by PRR and EB05 (the lower bound of the 90% CI of the EB geometric mean), for both crude and stratified; and (iii) to evaluate the effects of stratification by age and sex, in identifying adverse events that are accepted to be caused by vaccines. We applied EB and PRR data mining methods to data from the US Vaccine Adverse Event Reporting System (VAERS). We stratified PRR and EB05 by age and sex. To study the effects of stratification, we compared the crude PRR and stratified PRR. We also assessed the crude EB05 and stratified EB05, and then compared the effects of stratification on EB05 and PRR. Stratification not only changed the number of vaccine-event pairs that were highlighted, but also changed which pairs were highlighted. There were 283 vaccine-event pairs that were highlighted by the crude EB05, but not the stratified; 12 that were highlighted by the stratified EB05, but not the crude; and 162 that were highlighted by both. Similarly, there were 701 vaccine-event pairs that were highlighted by the crude PRR, but not the stratified; 139 that were highlighted by the stratified PRR, but not the crude; and 895 that were highlighted by both. There were 1466 vaccine-event pairs in which the effect of stratification was different for EB05 and PRR. To our knowledge, this is the first published analysis using stratified PRRs. In this analysis of passive surveillance data, stratification revealed and reduced confounding in EB and PRR, and also unmasked some vaccine-event pairs that the crude values did not highlight. Stratification should be applied if confounding is suspected. By decreasing the total number of highlighted vaccine-event pairs, stratification is likely to increase efficiency and therefore might reduce workload. JF - Drug safety AU - Woo, Emily Jane AU - Ball, Robert AU - Burwen, Dale R AU - Braun, M Miles AD - US Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland 20852, USA. jane.woo@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 667 EP - 674 VL - 31 IS - 8 SN - 0114-5916, 0114-5916 KW - Vaccines KW - 0 KW - Index Medicus KW - United States KW - Age Factors KW - United States Food and Drug Administration KW - Sex Factors KW - Humans KW - Bayes Theorem KW - Models, Statistical KW - Vaccines -- adverse effects KW - Databases, Factual -- statistics & numerical data KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69321946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Effects+of+stratification+on+data+mining+in+the+US+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29.&rft.au=Woo%2C+Emily+Jane%3BBall%2C+Robert%3BBurwen%2C+Dale+R%3BBraun%2C+M+Miles&rft.aulast=Woo&rft.aufirst=Emily&rft.date=2008-01-01&rft.volume=31&rft.issue=8&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Summary health statistics for the U.S. population: National Health Interview Survey, 2006. AN - 69317928; 18624012 AB - This report presents both age-adjusted and unadjusted health statistics from the 2006 National Health Interview Survey (NHIS) for the civilian noninstitutionalized population of the United States, classified by sex, age, race, Hispanic or Latino origin and race, education, family income, poverty status, health insurance coverage (where appropriate), place of residence, and region of residence. The topics covered are respondent-assessed health status, limitations in activities, special education or early intervention services, injury and poisoning episodes, health care access and utilization, and health insurance coverage. NHIS is a household, multistage probability sample survey conducted annually by interviewers of the U.S. Census Bureau for the Centers for Disease Control and Prevention's National Center for Health Statistics. In 2006, household interviews were completed for 75,716 persons living in 29,204 households, reflecting a household response rate of 87.3%. Nearly 7 in 10 persons were in excellent or very good health in 2006. About 36 million persons (12%) were limited in their usual activities due to one or more chronic health conditions. About 4 million persons (2%) required the help of another person with activities of daily living, and about 8 million persons (4%) required the help of another person with instrumental activities of daily living. About 6% of children received special education or early intervention services. Among persons under age 65 years, about 43 million (17%) did not have any health insurance coverage. The most common reason for lacking health insurance was cost, followed by a change in employment. JF - Vital and health statistics. Series 10, Data from the National Health Survey AU - Adams, Patricia F AU - Lucas, Jacqueline Wilson AU - Barnes, Patricia M AD - Division of Health Interview Statistics, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland 20782, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 104 IS - 236 SN - 0083-1972, 0083-1972 KW - Index Medicus KW - Wounds and Injuries -- epidemiology KW - Humans KW - Poisoning -- epidemiology KW - Activities of Daily Living KW - Aged KW - Child KW - Child, Preschool KW - Demography KW - Infant KW - Education, Special -- statistics & numerical data KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Insurance Coverage -- statistics & numerical data KW - Health Surveys KW - Health Status KW - Health Services Accessibility -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69317928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vital+and+health+statistics.+Series+10%2C+Data+from+the+National+Health+Survey&rft.atitle=Summary+health+statistics+for+the+U.S.+population%3A+National+Health+Interview+Survey%2C+2006.&rft.au=Adams%2C+Patricia+F%3BLucas%2C+Jacqueline+Wilson%3BBarnes%2C+Patricia+M&rft.aulast=Adams&rft.aufirst=Patricia&rft.date=2008-01-01&rft.volume=&rft.issue=236&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+10%2C+Data+from+the+National+Health+Survey&rft.issn=00831972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exercise stress testing in recently abstinent chronic cocaine abusers. AN - 69261552; 18584578 AB - We compared treadmill exercise stress testing (EST) in 28 medically screened, chronic cocaine users with the cardiovascular effects of an IV cocaine challenge (25 mg or 50 mg). All subjects had a clinically normal EST and echocardiography (except 2 subjects had septal wall hypokinesis). The EST produced significantly greater increases in heart rate and rate-pressure product than did the cocaine challenges. These findings suggest that EST may not provide additional diagnostic information in medically screened cocaine users. EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study). JF - The American journal of drug and alcohol abuse AU - Kanneganti, Praveen AU - Nelson, Richard A AU - Boyd, Susan J AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Department of Health and Human Services, Office of the Science Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224-2816, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 489 EP - 498 VL - 34 IS - 4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Echocardiography KW - Adult KW - Chronic Disease KW - Male KW - Female KW - Exercise Test KW - Heart Rate -- drug effects KW - Patient Compliance KW - Cardiovascular Diseases -- epidemiology KW - Substance Abuse, Intravenous -- rehabilitation KW - Cardiovascular Diseases -- chemically induced KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects KW - Cocaine -- administration & dosage KW - Cardiovascular Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69261552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Exercise+stress+testing+in+recently+abstinent+chronic+cocaine+abusers.&rft.au=Kanneganti%2C+Praveen%3BNelson%2C+Richard+A%3BBoyd%2C+Susan+J%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-01-01&rft.volume=34&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=1097-9891&rft_id=info:doi/10.1080%2F00952990802082214 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-14 N1 - Date created - 2008-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Aug 2;345(5):351-8 [11484693] Drug Alcohol Depend. 2006 Mar 15;82(1):19-24 [16144747] J Forensic Sci. 1978 Jan;23(1):173-89 [744960] Ann Intern Med. 1989 Dec 1;111(11):876-80 [2817640] Am J Med. 1990 Apr;88(4):325-31 [2327419] Am J Forensic Med Pathol. 1991 Jun;12(2):126-31 [1812853] J Addict Dis. 1991;10(4):47-65 [1777499] Circulation. 1992 Jul;86(1):226-31 [1535569] J Am Coll Cardiol. 1993 Nov 15;22(6):1581-6 [8227824] Chest. 1995 May;107(5):1426-34 [7750342] Chest. 1997 Oct;112(4):1008-16 [9377910] J Forensic Sci. 1998 Jan;43(1):41-5 [9456523] Pediatrics. 1963 Oct;32:SUPPL 742-56 [14070531] J Emerg Med. 2005 Aug;29(2):173-8 [16029829] Postgrad Med J. 2005 Sep;81(959):568-71 [16143686] Emerg Med Clin North Am. 2005 Nov;23(4):1083-103 [16199339] Heart Dis. 2003 Jul-Aug;5(4):253-71 [12877759] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00952990802082214 ER - TY - JOUR T1 - Mercaptobenzothiazole allergenicity-role of the thiol group. AN - 69244181; 18568896 AB - The rubber accelerator, 2-mercaptobenzothiazole (MBT), is known to cause allergic contact dermatitis (ACD), but the mechanism is unknown. The role of the thiol group in MBT's allergenicity was investigated in the present study. Guinea pigs were sensitized to MBT using a modified guinea pig maximization test (GPMT) and reactivity was assessed toward 2-mercaptobenzothiazole disulfide (MBTS), 2-hydroxybenzothiazole (HBT; thiol-substituted), 2-(methylthio)benzothiazole (MTBT; thiol-blocked), and benzothiazole (BT; thiol-lacking). MBT and MBTS, but not BT, HBT, or MTBT, elicited ACD in MBT-sensitized animals, demonstrating that the thiol group is critical to MBT's allergenicity. In addition, both MBT and MBTS were shown to inhibit both glutathione reductase and thioredoxin reductase, and thus contribute to the stability of MBT-protein mixed disulfides. It is concluded that the probable haptenation mechanism of MBT is through initial oxidation to MBTS with subsequent reduction to form mixed disulfides with proteins. JF - Cutaneous and ocular toxicology AU - Chipinda, Itai AU - Zhang, Xing-Dong AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 103 EP - 116 VL - 27 IS - 2 KW - Benzothiazoles KW - 0 KW - Disulfides KW - Haptens KW - Sulfhydryl Compounds KW - captax KW - 5RLR54Z22K KW - dibenzothiazyl disulfide KW - 6OK753033Z KW - Rubber KW - 9006-04-6 KW - Glutathione Reductase KW - EC 1.8.1.7 KW - Thioredoxin-Disulfide Reductase KW - EC 1.8.1.9 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Guinea Pigs KW - Skin -- pathology KW - Disulfides -- metabolism KW - Cross Reactions KW - Oxidation-Reduction KW - Rubber -- chemistry KW - Rubber -- adverse effects KW - Immunization -- methods KW - Disulfides -- immunology KW - Female KW - Haptens -- adverse effects KW - Sulfhydryl Compounds -- metabolism KW - Benzothiazoles -- adverse effects KW - Benzothiazoles -- metabolism KW - Thioredoxin-Disulfide Reductase -- antagonists & inhibitors KW - Haptens -- chemistry KW - Haptens -- metabolism KW - Dermatitis, Allergic Contact -- etiology KW - Sulfhydryl Compounds -- adverse effects KW - Sulfhydryl Compounds -- analysis KW - Dermatitis, Allergic Contact -- pathology KW - Glutathione Reductase -- antagonists & inhibitors KW - Benzothiazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69244181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutaneous+and+ocular+toxicology&rft.atitle=Mercaptobenzothiazole+allergenicity-role+of+the+thiol+group.&rft.au=Chipinda%2C+Itai%3BZhang%2C+Xing-Dong%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2008-01-01&rft.volume=27&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Cutaneous+and+ocular+toxicology&rft.issn=1556-9535&rft_id=info:doi/10.1080%2F15569520701713008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15569520701713008 ER - TY - JOUR T1 - To ban or not to ban--that is the question: the constitutionality of a moratorium on consumer drug advertising. AN - 69221723; 18561453 JF - Food and drug law journal AU - Schwartz, Mark I AD - Food and Drug Administration, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 33 VL - 63 IS - 1 SN - 1064-590X, 1064-590X KW - Pharmaceutical Preparations KW - 0 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Supreme Court Decisions KW - Government Regulation KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pharmaceutical Preparations -- economics KW - Community Participation KW - International Agencies KW - Guidelines as Topic KW - Patient Education as Topic -- legislation & jurisprudence KW - Drug Industry -- standards KW - Civil Rights -- legislation & jurisprudence KW - Advertising as Topic -- legislation & jurisprudence KW - Advertising as Topic -- standards KW - Legislation, Drug KW - Drug Industry -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69221723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+drug+law+journal&rft.atitle=To+ban+or+not+to+ban--that+is+the+question%3A+the+constitutionality+of+a+moratorium+on+consumer+drug+advertising.&rft.au=Schwartz%2C+Mark+I&rft.aulast=Schwartz&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=63&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Food+and+drug+law+journal&rft.issn=1064590X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-26 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Statistical issues including design and sample size calculation in thorough QT/QTc studies. AN - 69205031; 18470755 AB - After several drugs were removed from the market in recent years because of death due to ventricular tachycardia resulting from drug-induced QT prolongation (Khongphatthanayothin et al., 1998; Lasser et al., 2002; Pratt et al., 1994; Wysowski et al., 2001), the ICH Regulatory agencies requested all sponsors of new drugs to conduct a clinical study, named a Thorough QT/QTc (TQT) study, to assess any possible QT prolongation due to the study drug. The final version of the ICH E14 guidance (ICH, 2005) for "The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs" was released in May 2005. The purpose of the ICH E14 guidance (ICH, 2005) is to provide recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the potential of a drug to delay cardiac repolarization. The guideline, however, is not specific on several issues. In this paper, we try to address some statistical issues, including study design, primary statistical analysis, assay sensitivity analysis, and the calculation of the sample size for a TQT study. JF - Journal of biopharmaceutical statistics AU - Zhang, Joanne AU - Machado, Stella G AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 451 EP - 467 VL - 18 IS - 3 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - International Cooperation KW - Humans KW - Sample Size KW - Electrocardiography -- statistics & numerical data KW - Research Design -- statistics & numerical data KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Drugs, Investigational -- adverse effects KW - Long QT Syndrome -- physiopathology KW - Guidelines as Topic KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69205031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Statistical+issues+including+design+and+sample+size+calculation+in+thorough+QT%2FQTc+studies.&rft.au=Zhang%2C+Joanne%3BMachado%2C+Stella+G&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802020938 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802020938 ER - TY - JOUR T1 - Validation testing in thorough QT/QTc clinical trials. AN - 69204374; 18470761 AB - In order to validate the results of a thorough QT/QTc (the duration of depolarization and repolarization of ventricles or the duration corrected for heart rate) clinical trial, ICH E14 recommended to include a concurrent positive control treatment in the trial. It further recommended that validation is achieved if the positive control has an effect on the mean QT/QTc interval of about 5 ms. Zhang (2008) discussed the intersection-union test approach for testing the validation hypotheses and an alternative global average test approach. In this article, we further discuss the difference and relationship of the two sets of hypotheses and the difference in the efficiencies of the two approaches. We conclude that validation can be achieved if either one test rejects the null hypotheses without inflating the family-wise Type I error rate. However, using both approaches may improve the efficiency in validation assessment. JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Zhong, Jinglin AU - Chen, Wen Jen AD - Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 529 EP - 541 VL - 18 IS - 3 KW - Anti-Infective Agents KW - 0 KW - Aza Compounds KW - Fluoroquinolones KW - Placebos KW - Quinolines KW - moxifloxacin KW - U188XYD42P KW - Index Medicus KW - Control Groups KW - Anti-Infective Agents -- adverse effects KW - Humans KW - Aza Compounds -- adverse effects KW - Guidelines as Topic KW - Quinolines -- adverse effects KW - Validation Studies as Topic KW - Electrocardiography -- standards KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69204374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Validation+testing+in+thorough+QT%2FQTc+clinical+trials.&rft.au=Tsong%2C+Yi%3BZhong%2C+Jinglin%3BChen%2C+Wen+Jen&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995486 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Biopharm Stat. 2010 May;20(3):683-7; author reply 688 [20358445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995486 ER - TY - JOUR T1 - Statistical issues of QT prolongation assessment based on linear concentration modeling. AN - 69203431; 18470764 AB - The ICH (2005) defined drug-induced prolongation of QT interval, i.e., the duration of depolarization and repolarization of ventricles, as evidenced by an upper bound of the 95% confidence interval around the mean effect on QTc (QT corrected for heart rate) of 10 ms. Furthermore, it defined that a negative thorough QT/QTc study is one in which the upper bound of the 95% one-sided confidence interval for the largest time-matched mean effect of the drug on the QTc interval excludes 10 ms. This objective leads to the application of intersection-union tests by testing the mean difference between test treatment and placebo of QTc change from baseline at each of the matched time points at which the observations are collected. The nature of the higher false positive rate due to more observational time points leads to the concern of study efficiency. Based on the concept of clinical pharmacology, a concentration-response modeling approach is often adopted to assess the prolongation size of QTc interval induced by a drug without carefully examining the validity of the assumptions involved. In most of the applications, the model is assumed either to be linear, log-linear, or logistic. The supporter of the modeling often emphasizes the advantage of power improvement and reduction in estimation error. However, it has been often pointed out by statisticians and pharmacologists that modeling under an invalid uniformity assumption across study population often leads to severe bias in testing and estimation. In this article, we examine data sets of New Drug Applications to illustrate the bias and lack of validity of the linearity assumptions. JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Shen, Meiyu AU - Zhong, Jinglin AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 564 EP - 584 VL - 18 IS - 3 KW - Anti-Infective Agents KW - 0 KW - Aza Compounds KW - Fluoroquinolones KW - Quinolines KW - moxifloxacin KW - U188XYD42P KW - Index Medicus KW - Humans KW - Linear Models KW - Aza Compounds -- administration & dosage KW - Quinolines -- adverse effects KW - Quinolines -- administration & dosage KW - Anti-Infective Agents -- adverse effects KW - International Cooperation KW - Anti-Infective Agents -- administration & dosage KW - Aza Compounds -- adverse effects KW - Guidelines as Topic KW - Sample Size KW - Time Factors KW - Electrocardiography -- standards KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69203431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Statistical+issues+of+QT+prolongation+assessment+based+on+linear+concentration+modeling.&rft.au=Tsong%2C+Yi%3BShen%2C+Meiyu%3BZhong%2C+Jinglin%3BZhang%2C+Joanne&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995502 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Biopharm Stat. 2010 May;20(3):689-92; author reply 693-7 [20358447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995502 ER - TY - JOUR T1 - Testing for positive control activity in a thorough QTc study. AN - 69202550; 18470760 AB - The ICH E14 guidance (ICH, 2005) recommend that a concurrent positive control should be included in a thorough QTc clinical trial to validate the study. The ICH E14 guidance (ICH, 2005) state that "The positive control should have an effect on the mean QTc interval of about 5 ms (i.e., an effect that is close to the QTc effect that represents the threshold of regulatory concern, around 5 ms)". This task may be carried out through some statistical tests. The current practice is to test at each time point where QT measurements are collected. This method is usually not efficient. In this article, I discuss two types of statistical procedures. The first one is a local statistical test to make a time-point-specific claim, i.e., to claim a mild QTc effect due to the positive control at some specific time points. A different approach, named as a global test, is also proposed, to make a general claim that the mean difference of the positive control and placebo after baseline adjustment will be about 5 ms without specifying at which time points. An example will be used to illustrate how to apply the two procedures. How to best allocate sample size in a parallel QTc study is also discussed in this paper. JF - Journal of biopharmaceutical statistics AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 517 EP - 528 VL - 18 IS - 3 KW - Index Medicus KW - Humans KW - Electrocardiography -- standards KW - Research Design -- statistics & numerical data KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Control Groups KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69202550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Testing+for+positive+control+activity+in+a+thorough+QTc+study.&rft.au=Zhang%2C+Joanne&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995478 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995478 ER - TY - JOUR T1 - Guest editors' notes on statistical issues in design and analysis of thorough QTc studies. AN - 69202047; 18470752 JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. yi.tsong@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 405 EP - 407 VL - 18 IS - 3 KW - Placebos KW - 0 KW - Index Medicus KW - Heart Rate -- drug effects KW - Humans KW - Heart Rate -- physiology KW - Electrocardiography -- statistics & numerical data KW - Research Design -- statistics & numerical data KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Long QT Syndrome -- physiopathology KW - Clinical Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69202047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Guest+editors%27+notes+on+statistical+issues+in+design+and+analysis+of+thorough+QTc+studies.&rft.au=Tsong%2C+Yi%3BZhang%2C+Joanne&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802029509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802029509 ER - TY - JOUR T1 - Mining sector. AN - 69180082; 18454967 JF - Journal of safety research AU - Bealko, Susan B AU - Kovalchik, Peter G AU - Matetic, Rudy J AD - National Institute for Occupational Safety and Health (NIOSH), USA. sbealko@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 187 EP - 189 VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Index Medicus KW - Organizational Policy KW - Humans KW - Organizational Culture KW - Occupational Health KW - Environment Design KW - Accidents, Occupational -- prevention & control KW - Workplace KW - Mining KW - Safety Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69180082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=Mining+sector.&rft.au=Bealko%2C+Susan+B%3BKovalchik%2C+Peter+G%3BMatetic%2C+Rudy+J&rft.aulast=Bealko&rft.aufirst=Susan&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.004 ER - TY - JOUR T1 - Application of Prevention through Design for hearing loss in the mining industry. AN - 69179559; 18454977 AB - Overexposure to noise remains a widespread and serious health hazard in the U.S. service providing and goods producing industries. Excessive noise can lead to poor verbal communication and reduce the ability to recognize warning signals. These dangerous work conditions can also cause stress and fatigue. Occupational hearing loss is a permanent illness, with no recovery currently possible. National Institute for Occupational Safety and Health (NIOSH) has recognized Noise Induced Hearing Loss (NIHL) as one of the ten leading work-related diseases and injuries in the United States, and has emphasized its importance as one of the critical areas expressed in the National Occupational Research Agenda. One of the most serious noise problems in the goods producing industries is the operation of continuous mining machines during underground coal mining. In order to minimize occupational hearing loss, noise hazards are "designed out" early in the design process. NIOSH is leading a national initiative called Prevention through Design (PTD) to promote this concept. This paper describes the quiet-by-design approach of a noise control that reduced noise exposures of continuous mining machine operators by 3dB(A) using the four functional areas of PTD, namely Practice, Policy, Research, and Education. JF - Journal of safety research AU - Kovalchik, Peter G AU - Matetic, Rudy J AU - Smith, Adam K AU - Bealko, Susan B AD - National Institute for Occupational Safety and Health, USA. PKovalchik@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 251 EP - 254 VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Index Medicus KW - United States KW - Models, Educational KW - Occupational Health KW - Educational Status KW - Humans KW - Program Development KW - Program Evaluation KW - National Institute for Occupational Safety and Health (U.S.) KW - Environment Design KW - Occupational Exposure -- adverse effects KW - Mining KW - Noise -- adverse effects KW - Hearing Loss -- etiology KW - Industry KW - Hearing Loss -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69179559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=Application+of+Prevention+through+Design+for+hearing+loss+in+the+mining+industry.&rft.au=Kovalchik%2C+Peter+G%3BMatetic%2C+Rudy+J%3BSmith%2C+Adam+K%3BBealko%2C+Susan+B&rft.aulast=Kovalchik&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.029 ER - TY - JOUR T1 - National Prevention through Design (PtD) Initiative. AN - 69174412; 18454950 AB - The most effective means of preventing and controlling occupational injuries, illness, and fatalities is to "design out" hazards and hazardous exposures from the workplace. There is a long history of designing for safety for the general public and to a lesser degree for workers. We now have the experience and insight from thoughtful, previous efforts to call for a comprehensive national strategy to implement a Prevention through Design (PtD) Initiative. This paper describes that initiative in terms of four overarching areas where action can be directed: practice, policy, research, and education. To obtain stakeholder input for issues in these four areas and to focus implementation efforts, eight sector divisions of the economy will be addressed. A seven year strategy is envisioned. JF - Journal of safety research AU - Schulte, Paul A AU - Rinehart, Richard AU - Okun, Andrea AU - Geraci, Charles L AU - Heidel, Donna S AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, USA. pas4@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 115 EP - 121 VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Index Medicus KW - United States KW - Humans KW - Public Policy KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Safety Management -- standards KW - Environment Design -- standards KW - Workplace -- standards KW - Program Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69174412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=National+Prevention+through+Design+%28PtD%29+Initiative.&rft.au=Schulte%2C+Paul+A%3BRinehart%2C+Richard%3BOkun%2C+Andrea%3BGeraci%2C+Charles+L%3BHeidel%2C+Donna+S&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.021 ER - TY - JOUR T1 - Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications. AN - 69160134; 18449482 AB - The generation of high-quality microarray data for toxicogenomics can be affected by the study design and methods used for sample acquisition, preparation, and processing. Bias can be introduced during animal treatment, tissue handling, and sample preparation. Metrics and controls used in assessing RNA integrity and the quality of microarray sample generation are reviewed in this chapter. Regulations and guidelines involved in the application of microarrays as a commercial in vitro diagnostic device are also described. JF - Methods in molecular biology (Clifton, N.J.) AU - Thompson, Karol L AU - Hackett, Joseph AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 45 EP - 68 VL - 460 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - In Vitro Techniques KW - Diagnostic Tests, Routine KW - Quality Control KW - Toxicology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69160134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Quality+control+of+microarray+assays+for+toxicogenomic+and+in+vitro+diagnostic+applications.&rft.au=Thompson%2C+Karol+L%3BHackett%2C+Joseph&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2008-01-01&rft.volume=460&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-60327-048-9_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-048-9_3 ER - TY - JOUR T1 - Informatic tools and approaches in postmarketing pharmacovigilance used by FDA. AN - 69157025; 18446503 AB - The safety profile of newly approved drugs and therapeutic biologics is less well developed by pre-marketing clinical testing than is the efficacy profile. The full safety profile of an approved product is established during years of clinical use. For nearly 40 years, the FDA has relied on the voluntary reporting of adverse events by healthcare practitioners and patients to help establish the safety of marketed products. Epidemiologic studies, including case series, secular trends, case-control and cohort studies, are used to supplement the investigation of a safety signal. Ideally, active surveillance systems would supplement the identification and exploration of safety signals. The FDA has implemented a number of initiatives to help identify safety problems with drugs and continues to evaluate their efforts. JF - The AAPS journal AU - Weaver, Joyce AU - Willy, Mary AU - Avigan, Mark AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20903-0002, USA. joyce.weaver@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 35 EP - 41 VL - 10 IS - 1 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - Drugs, Investigational -- pharmacology KW - Animals KW - Adverse Drug Reaction Reporting Systems -- standards KW - Humans KW - Adverse Drug Reaction Reporting Systems -- trends KW - Drugs, Investigational -- adverse effects KW - Medical Informatics -- trends KW - United States Food and Drug Administration -- trends KW - Medical Informatics -- standards KW - United States Food and Drug Administration -- standards KW - Product Surveillance, Postmarketing -- trends KW - Product Surveillance, Postmarketing -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69157025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Informatic+tools+and+approaches+in+postmarketing+pharmacovigilance+used+by+FDA.&rft.au=Weaver%2C+Joyce%3BWilly%2C+Mary%3BAvigan%2C+Mark&rft.aulast=Weaver&rft.aufirst=Joyce&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-007-9004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-22 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Saf. 2002;25(6):381-92 [12071774] Drug Saf. 2003;26(3):159-86 [12580646] Hepatology. 2004 Oct;40(4):773 [15382161] J R Soc Med. 1991 Jun;84(6):341-4 [2061900] JAMA. 2006 Oct 18;296(15):1858-66 [17047216] Chest. 2006 Jan;129(1):15-26 [16424409] N Engl J Med. 2006 Mar 2;354(9):924-33 [16510746] Arch Gen Psychiatry. 2006 Mar;63(3):332-9 [16520440] Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):311-3 [16611207] Drug Saf. 2005;28(10):917-24 [16180941] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-007-9004-5 ER - TY - JOUR T1 - Pharmacogenetic and metabolic differences between dog breeds: their impact on canine medicine and the use of the dog as a preclinical animal model. AN - 69151655; 18446511 AB - There is limited information describing species related pharmacogenetic differences in animals. Despite the lack of genetic information in veterinary medicine, breed specific responses to endogenous and exogenous substances have been reported across many species. This finding underscores the importance of obtaining insight into the genotypic and phenotypic variation present across breeds. This article provides a summary of the literature pertaining to canine breed differences in physiology, drug response, drug pharmacokinetics, and metabolic idiosyncrasies. The existing knowledge of pedigrees and the known phenotypes and genotypes of dogs provides important information for determining mode of inheritance, penetration, and other major characteristics of heritable traits. Understanding these breed differences will improve canine population predictions (for canine drug products) and may be of value when extrapolating toxicology data from dogs to humans. JF - The AAPS journal AU - Fleischer, Steven AU - Sharkey, Michele AU - Mealey, Katrina AU - Ostrander, Elaine A AU - Martinez, Marilyn AD - Center for Veterinary Medicine, The Food and Drug Administration, 7500 Standish Place, HFV-130, Rockville, Massachusetts 20855, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 110 EP - 119 VL - 10 IS - 1 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Drug Evaluation, Preclinical -- methods KW - Species Specificity KW - Models, Animal KW - Pharmaceutical Preparations -- metabolism KW - Veterinary Medicine -- methods KW - Dogs -- genetics KW - Pharmacogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69151655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Pharmacogenetic+and+metabolic+differences+between+dog+breeds%3A+their+impact+on+canine+medicine+and+the+use+of+the+dog+as+a+preclinical+animal+model.&rft.au=Fleischer%2C+Steven%3BSharkey%2C+Michele%3BMealey%2C+Katrina%3BOstrander%2C+Elaine+A%3BMartinez%2C+Marilyn&rft.aulast=Fleischer&rft.aufirst=Steven&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-008-9011-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-22 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Vet Res. 1986 Oct;47(10):2105-12 [3777630] J Toxicol Environ Health. 1984;13(4-6):721-33 [6436504] Res Vet Sci. 1993 Jan;54(1):63-7 [8434150] Am J Vet Res. 1993 May;54(5):755-60 [8317769] Pharm Res. 1993 Jul;10(7):1087-9 [8378252] J Small Anim Pract. 1995 Aug;36(8):354-9 [8558867] Biochem Pharmacol. 1997 Jul 1;54(1):73-80 [9296352] Drug Metab Dispos. 1998 Mar;26(3):278-83 [9492393] Prev Vet Med. 1998 May 1;35(2):115-24 [9646335] Drug Metab Dispos. 1999 Oct;27(10):1133-42 [10497139] Vet Radiol Ultrasound. 1999 Sep-Oct;40(5):465-71 [10528839] Vet Rec. 1999 Nov 27;145(22):625-9 [10619607] J Vet Intern Med. 2000 Jan-Feb;14(1):1-9 [10668810] Prev Vet Med. 2000 Jul 3;46(1):1-14 [10854932] Drug Metab Dispos. 2000 Aug;28(8):981-6 [10901710] Xenobiotica. 2000 Jun;30(6):575-88 [10923860] Genome Res. 2000 Sep;10(9):1271-4 [10984444] Vet Clin North Am Small Anim Pract. 2001 Mar;31(2):421-31 [11265501] J Am Anim Hosp Assoc. 2001 Sep-Oct;37(5):444-52 [11563443] Res Vet Sci. 2001 Aug;71(1):45-9 [11666147] Am J Vet Res. 2002 May;63(5):677-82 [12013468] J Nutr. 2002 Jun;132(6 Suppl 2):1679S-81S [12042491] Vet J. 2002 Jul;164(1):47-53 [12359484] J Nutr. 2002 Nov;132(11):3363-8 [12421852] Pharmacogenetics. 2002 Dec;12(9):713-24 [12464800] J Anim Sci. 2003 Jun;81(6):1568-80 [12817506] Mamm Genome. 2003 Jul;14(7):483-91 [12925897] Am J Vet Res. 2003 Sep;64(9):1105-9 [13677387] Science. 2003 Sep 26;301(5641):1898-903 [14512627] Drug Metab Dispos. 2004 Feb;32(2):240-5 [14744947] J Appl Genet. 2004;45(2):195-214 [15131351] Science. 2004 May 21;304(5674):1160-4 [15155949] Mamm Genome. 2004 Jun;15(6):503-6 [15181542] J Vet Pharmacol Ther. 2004 Jun;27(3):129-38 [15189298] J Nutr. 2004 Aug;134(8 Suppl):2039S-2041S [15284397] J Vet Pharmacol Ther. 2004 Oct;27(5):257-64 [15500562] J Natl Cancer Inst. 1968 Feb;40(2):295-305 [5694271] J Natl Cancer Inst. 1968 Feb;40(2):307-18 [5694272] Pharmacogenetics. 2004 Nov;14(11):769-73 [15564884] Am J Vet Res. 2004 Nov;65(11):1573-9 [15566097] Xenobiotica. 2004 Sep;34(9):835-46 [15742977] J Anim Physiol Anim Nutr (Berl). 2005 Apr-Jun;89(3-6):189-93 [15787993] J Anim Sci. 2005 Sep;83(9):2087-95 [16100063] Genome Res. 2005 Dec;15(12):1706-16 [16339369] Nature. 2005 Dec 8;438(7069):803-19 [16341006] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D590-8 [16381938] J Vet Med A Physiol Pathol Clin Med. 2006 Mar;53(2):97-107 [16466463] Vet Clin North Am Small Anim Pract. 2006 May;36(3):461-74, v [16564409] Am J Vet Res. 2006 May;67(5):909-18 [16649929] PLoS Genet. 2005 Nov;1(5):e58 [16311623] J Biochem Mol Biol. 2006 May 31;39(3):240-6 [16756751] Theriogenology. 2006 Sep 1;66(4):896-905 [16580718] J Vet Intern Med. 2006 Jul-Aug;20(4):894-903 [16955814] Arch Toxicol. 2006 Nov;80(11):732-8 [16639591] Science. 2007 Apr 6;316(5821):112-5 [17412960] Vet J. 2007 Sep;174(2):252-9 [17085062] Genome Res. 2007 Nov;17(11):1562-71 [17916641] J Natl Cancer Inst. 1971 Dec;47(6):1333-44 [5120412] Curr Med Res Opin. 1976;4(5):309-29 [64332] Acta Endocrinol (Copenh). 1984 Mar;105(3):294-301 [6367329] Am J Vet Res. 1984 Jan;45(1):137-44 [6422804] Acta Endocrinol (Copenh). 1984 Aug;106(4):448-53 [6382895] Vet Res Commun. 1990;14(3):241-52 [2382408] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-008-9011-1 ER - TY - RPRT T1 - National Survey of Child and Adolescent Well-Being, No. 12: Estimates of Supplemental Security Income Eligibility for Children in Out-of-Home Placements. Research Brief: Findings from the NSCAW Study AN - 61960813; ED501307 AB - Children who have been placed in foster care have been found to be at a high risk of having a medical, social or behavioral disability. This brief, one in a series of briefs addressing access to services for children in the child welfare system, examines Supplemental Security Income (SSI) eligibility among children living in out-of-home placements in the child welfare system, using data from the National Survey of Child and Adolescent Well-Being. The analysis indicates that a large number of children living in foster care may be eligible for SSI. The rates of SSI eligibility we estimate vary depending on children's age, race/ethnicity, gender and locality of placement. (Contains 4 tables and 11 notes.) Y1 - 2008 PY - 2008 DA - 2008 SP - 8 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Gender Differences KW - Place of Residence KW - Welfare Services KW - Racial Differences KW - Foster Care KW - Child Welfare KW - Age Differences KW - Eligibility KW - Placement KW - Income UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61960813?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Monitoring and Technical Assistance Review System Notebook AN - 61959051; ED501839 AB - This notebook provides guidance on the Monitoring and Technical Assistance Review System (MTARS). The manual is intended for use by Administration on Developmental Disabilities (ADD) staff who manage MTARS and by MTARS reviewers who conduct site visit activities. The notebook is also designed to help Councils, Protection and Advocacy Systems, and University Centers for Excellence in Developmental Disabilities prepare for and participate in MTARS activities. The notebook describes procedures for each stage of the MTARS process and is organized into seven sections: (1) Overview of the Developmental Disabilities Assistance and Bill of Rights Act of 2000 (DD Act) and ADD; (2) Monitoring and Technical Assistance Review System; (3) MTARS Team; (4) Planning Activities; (5) Pre-Site Visit Activities; (6) MTARS Site Visit; and (7) Post-Site Visit Activities. Tables, checklists, glossary and additional information are appended. (Contains 31 tables.) Y1 - 2008 PY - 2008 DA - 2008 SP - 223 PB - Administration for Children & Families. U.S. Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - Developmental Disabilities Act KW - Developmental Disabled Assist Bill of Rights Act KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Self Evaluation (Individuals) KW - Developmental Disabilities KW - Grants KW - Observation KW - Evaluators KW - Accountability KW - Human Services KW - Federal Legislation KW - Public Agencies KW - Innovation KW - Planning KW - Check Lists KW - Compliance (Legal) KW - Program Evaluation KW - Technical Assistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61959051?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - More about the Dads: Exploring Associations between Nonresident Father Involvement and Child Welfare Case Outcomes AN - 61947640; ED501299 AB - This study follows up on a prior study of child welfare agencies' efforts to identify, locate, and involve nonresident fathers of children in foster care. These analyses use information from the original survey and administrative data on case outcomes to explore three research questions: (1) Is nonresident father involvement associated with case length? (2) Is nonresident father involvement associated with foster care discharge outcomes? and (3) Is nonresident father involvement associated with subsequent child maltreatment allegations? The study finds that having an involved father is associated with shorter case length and a greater likelihood of reunification. Findings also indicate that, contrary to some caseworkers' fears, nonresident fathers' contact with the child welfare agency and involvement with their children is not associated with subsequent maltreatment allegations. The results, though exploratory, suggest that engaging the nonresident fathers of children in foster care could potentially improve outcomes for the children. Further research is needed to better understand the association between nonresident fathers' involvement and a greater likelihood of reunification. (Contains 2 tables, 7 figures, and 34 footnotes.) [This report was prepared by the Urban Institute under contract to the Office of the Assistant Secretary for Planning and Evaluation of the U.S. Department of Health and Human Services.] AU - Malm, Karin AU - Zielewski, Erica AU - Chen, Henry Y1 - 2008 PY - 2008 DA - 2008 SP - 30 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Followup Studies KW - Parent Child Relationship KW - Welfare Services KW - Child Abuse KW - Fathers KW - Child Welfare KW - Foster Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947640?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Substance Abuse and Mental Health Services Administration. March/April 2008 AN - 61947049; ED501549 AB - "SAMHSA News" is the national newsletter of the Substance Abuse and Mental Health Services Administration. Published six times a year (bimonthly) by SAMHSA's Office of Communications, SAMHSA News contains information about the latest substance abuse and mental health treatment and prevention practices, recent statistics on mental health and addictive disorders, related Federal policies, and available resources. Articles in this issue include: (1) Screening Works: Update from the Field (Rebecca A. Clay); (2) Administrator's Message: Behavioral Health Screening and Primary Care (Terry L. Cline); (3) Screening in Action: For SBIRT Grantees Across the Nation, Flexibility Helps (Rebecca A. Clay); (4) President's Budget Focuses on Priority Initiatives; (5) Teens and Drug Use: Stimulant Use and Delinquent Behavior; (6) Statistics on Inhalants Show Young Teens at Risk; (7) State by State: Substance Use, Mental Health Statistics; (8) New Data on Treatment Admissions: Alcohol Abuse Highest, but Methamphetamine, Marijuana, Prescription Painkillers on the Rise; (9) Study Helps Dispel Substance Use Myth: Rural Communities at Risk (Erin Bryant); and (10) Making Workplaces Drug-Free. AU - Goodman, Deborah Y1 - 2008 PY - 2008 DA - 2008 SP - 16 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov VL - 16 IS - 2 KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Substance Abuse KW - Statistics KW - Delinquency KW - Grants KW - Mental Health Programs KW - Stimulants KW - Mental Health KW - Marijuana KW - Behavior Problems KW - Rural Areas KW - Screening Tests KW - Health Services KW - Alcohol Abuse KW - Inhalants KW - Misconceptions KW - Occupational Safety and Health KW - Incidence KW - Budgets KW - Work Environment KW - Adolescents KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947049?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Connecting Social and Emotional Learning with Mental Health AN - 61893862; ED505361 AB - As knowledge of effective treatments for mental disorders has grown, so too has the field of mental health promotion and positive development. Studies completed during the last two decades have synthesized the state of mental health promotion and documented that universal mental health supports positively affect child and adolescent developmental outcomes. Given schools' ability to access large numbers of children, they are commonly identified as the best place to provide supports to promote the universal mental health of children. This report explains the relationship between mental health and the promotion of social and emotional learning (SEL). Strategies for connecting mental health and SEL in the school setting include: (1) Implementing supportive public policies; (2) Developing safe, caring, and supportive environments; (3) Providing direct instruction for students on skills and strategies; (4) Creating infrastructure for community action; and (5) Coordinating with community agencies, schools, families, and students to create a common vision, language, and coordinated services to support healthy outcomes. A list of resources is included. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 PB - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Program Effectiveness KW - Community Action KW - Guidelines KW - Child Health KW - Mental Health KW - Public Policy KW - Emotional Development KW - Health Promotion KW - Educational Environment KW - Public Health KW - Public Agencies KW - Mental Disorders KW - Program Implementation KW - School Role KW - Program Development KW - Social Development KW - Program Evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61893862?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Social and Emotional Learning (SEL) and Student Benefits: Implications for the Safe Schools/Healthy Students Core Elements AN - 61890878; ED505369 AB - This brief shares the latest research on the effects of social and emotional learning (SEL) on students and includes strategies for implementing SEL. It explains how SEL works, elaborates on how SEL can be an integrative prevention framework that addresses the Safe Schools/Healthy Students (SS/HS) core elements, and spells out implications of the research for SS/HS grantees. Several hundred well-designed studies have documented the effects of SEL programming on students of diverse backgrounds, from preschool through high school, in urban, suburban, and rural settings. The research indicates that well-planned and well-implemented SEL programming can positively affect a broad range of student social, health, behavioral, and academic outcomes. (Contains 22 endnotes, 1 figure and 1 table.) Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Program Effectiveness KW - Research Reports KW - Child Health KW - School Safety KW - Emotional Development KW - Outcomes of Education KW - Prevention KW - Educational Environment KW - Program Implementation KW - Federal Programs KW - Program Development KW - Social Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61890878?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - U.S. Health Spending By Age, Selected Years Through 2004: Recent trends indicate that per person spending for the oldest elderly is growing more slowly than spending for all other age groups AN - 58774822; 2008-171174 AB - This paper examines variations in health spending by children, working-age adults, and seniors for selected years between 1987 and 2004. Seniors spent far more per person than children or working-age adults, but the relative gap between the age groups has not changed much since 1987 except for those age eighty-five and older. Since the inception of the State Children's Health Insurance Program (SCHIP) in 1997, the proportion of children's health spending financed by public sources has increased, while the share paid for out of pocket has decreased. The future age-mix is expected to have a major impact on nursing home spending growth while minimally affecting overall Medicare spending growth. Adapted from the source document. JF - Health Affairs AU - Hartman, Micah AU - Catlin, Aaron AU - Lassman, David AU - Cylus, Jonathan AU - Heffler, Stephen AD - National Health Statistics Group, Office of the Actuary, Centers for Medicare and Medicaid Services, Baltimore, Maryland micah.hartman@cms.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - w1 EP - w12 PB - Project HOPE, Bethesda MD VL - 27 IS - Supplement SN - 0278-2715, 0278-2715 KW - Population groups, population policy, and demographics - Children and youth KW - Population groups, population policy, and demographics - Demography and census KW - Health conditions and policy - Health and health policy KW - Medicare KW - Old age KW - Health policy KW - Adults KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58774822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=U.S.+Health+Spending+By+Age%2C+Selected+Years+Through+2004%3A+Recent+trends+indicate+that+per+person+spending+for+the+oldest+elderly+is+growing+more+slowly+than+spending+for+all+other+age+groups&rft.au=Hartman%2C+Micah%3BCatlin%2C+Aaron%3BLassman%2C+David%3BCylus%2C+Jonathan%3BHeffler%2C+Stephen&rft.aulast=Hartman&rft.aufirst=Micah&rft.date=2008-01-01&rft.volume=27&rft.issue=Supplement&rft.spage=w1&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.27.1.w1 LA - English DB - PAIS Index N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Children; Adults; Old age; Medicare DO - http://dx.doi.org/10.1377/hlthaff.27.1.w1 ER - TY - BOOK T1 - Guidelines for the Development of a New Miner Training Curriculum AN - 58769727; 2008-150286 AB - This report is intended to help mine safety trainers better prepare to teach the influx of new underground coal miners who are entering the industry. This is done by identifying two different approaches to instruction and discussing the ways they may affect how well prepared new hires are to deal with a dynamic and hazardous workplace. One approach is based on the use of a syllabus. Those using a syllabus are more likely to rely on lecturing or direct instruction. This is a good way to get across factual information, but does not provide a context within which miners can fit the discrete facts so that they form an integrated whole set of concepts, principles, and skills. The other approach is based on the use of a curriculum. Those using a curriculum may be more likely to help miners integrate concepts and skills that give them an overall picture of the complex mining environment and how they fit into the workplace. Tables, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jan 2008, 30 pp. AU - Mallett, Launa G AU - Vaught, Charles Y1 - 2008/01// PY - 2008 DA - January 2008 EP - 30p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Education and education policy - Curriculum KW - Business and service sector - Business operations, practices, and workplaces KW - Social conditions and policy - Public safety and security KW - Curriculum KW - Miners KW - Safety measures KW - Workplaces KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58769727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mallett%2C+Launa+G%3BVaught%2C+Charles&rft.aulast=Mallett&rft.aufirst=Launa&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=30p&rft.isbn=&rft.btitle=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.title=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2008-105.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-105 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Health Spending Projections through 2017: The Baby-Boom Generation is Coming to Medicare. Accelerating growth in Medicare spending by the end of the projection period is the first sign of the coming demographic shift. AN - 58768017; 2008-173726 AB - The outlook for national health spending calls for continued steady growth. Spending growth is projected to be 6.7 percent in 2007, similar to its rate in 2006. Average annual growth over the projection period is expected to be 6.7 percent. Slower growth in private spending toward the end of the period is expected to be offset by stronger growth in public spending. The health share of gross domestic product (GDP) is expected to increase to 16.3 percent in 2007 & then rise throughout the projection period, reaching 19.5 percent of GDP by 2017. Tables, Graphs. Adapted from the source document. JF - Health Affairs AU - Keehan, Sean AU - Sisko, Andrea AU - Truffer, Christopher AU - Smith, Sheila AU - Cowan, Cathy AU - Poisal, John AU - Clemens, M Kent AU - National Health Expenditure Accounts Projections Team AD - NHSG e-mail:DNHS@cms.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - w145 EP - w155 PB - Project HOPE, Bethesda MD VL - 27 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Economic conditions and policy - Economic conditions KW - Medicare KW - Health policy KW - Economic conditions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58768017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Health+Spending+Projections+through+2017%3A+The+Baby-Boom+Generation+is+Coming+to+Medicare.+Accelerating+growth+in+Medicare+spending+by+the+end+of+the+projection+period+is+the+first+sign+of+the+coming+demographic+shift.&rft.au=Keehan%2C+Sean%3BSisko%2C+Andrea%3BTruffer%2C+Christopher%3BSmith%2C+Sheila%3BCowan%2C+Cathy%3BPoisal%2C+John%3BClemens%2C+M+Kent%3BNational+Health+Expenditure+Accounts+Projections+Team&rft.aulast=Keehan&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=27&rft.issue=&rft.spage=w145&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medicare; Health policy; Economic conditions ER - TY - JOUR T1 - National Health Spending In 2006: A Year Of Change For Prescription Drugs AN - 58755374; 2008-127806 AB - In 2006, U.S. health care spending increased 6.7 percent to $.1 trillion, or $7,026 per person. The health care portion of gross domestic product (GDP) was 16.0 percent, slightly higher than in 2005. Prescription drug spending growth accelerated in 2006 to 8.5 percent, partly as a result of Medicare Part D's impact. Most of the other major health care services and public payers experienced slower growth in 2006 than in prior years. The implementation of Medicare Part D caused a major shift in the distribution of payers for prescription drugs, as Medicare played a larger role in drug purchases than it had before. Adapted from the source document. JF - Health Affairs AU - Catlin, Aaron AU - Cowan, Cathy AU - Hartman, Micah AU - Heffler, Stephen AD - National Health Statistics Group, CMS Office, Actuary, Catlin aaron.catlin@cms.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 14 EP - 29 PB - Project HOPE, Bethesda MD VL - 27 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Business finance KW - Health conditions and policy - Medicine and health care KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Prescriptions KW - Public health administration KW - United States KW - Finance KW - Appropriations and expenditures KW - Medicare KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=National+Health+Spending+In+2006%3A+A+Year+Of+Change+For+Prescription+Drugs&rft.au=Catlin%2C+Aaron%3BCowan%2C+Cathy%3BHartman%2C+Micah%3BHeffler%2C+Stephen&rft.aulast=Catlin&rft.aufirst=Aaron&rft.date=2008-01-01&rft.volume=27&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.27.1.14 LA - English DB - PAIS Index N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States; Public health administration; Finance; Prescriptions; Medicare; Appropriations and expenditures DO - http://dx.doi.org/10.1377/hlthaff.27.1.14 ER - TY - JOUR T1 - Laws, leaders, and legends of the modern National Library of Medicine. AN - 57708135; 200804798 AB - Purpose: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. Brief Description: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements - namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information - transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates - including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper - together contributed to the creation of the modern NLM. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Smith, Kent A AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ksmith@kasenterprise.com Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 121 EP - 133 PB - Medical Library Association, Chicago, IL VL - 96 IS - 2 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - Law KW - Library history KW - Medical libraries KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Laws%2C+leaders%2C+and+legends+of+the+modern+National+Library+of+Medicine.&rft.au=Smith%2C+Kent+A&rft.aulast=Smith&rft.aufirst=Kent&rft.date=2008-01-01&rft.volume=96&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.96.2.121 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical libraries; Library history; Law; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.96.2.121 ER - TY - JOUR T1 - A Concept Analysis: Adherence and Weight Loss AN - 57299521; 200916884 AB - There are numerous factors that influence an individual's ability to adhere to a healthy behavior. The literature cites common events that must take place prior to maintaining an exercise plan, a medication regimen, and a healthy diet. The purpose of this paper is to examine the concept of adherence in relation to weight loss using Walker and Avant's (1995) framework for concept analysis. This analysis revealed an extensive list of events or antecedents that may prove to be important when considering new strategies for weight management. Adapted from the source document. JF - Nursing Forum AU - Shay, Laura E AD - Uniformed Services University, Bethesda, MD laura.shay@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 42 EP - 52 PB - Wiley-Blackwell, UK VL - 43 IS - 1 SN - 0029-6473, 0029-6473 KW - Healthy habits KW - Concept analysis KW - Adherence KW - Weight loss KW - Exercise KW - Diet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57299521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=A+Concept+Analysis%3A+Adherence+and+Weight+Loss&rft.au=Shay%2C+Laura+E&rft.aulast=Shay&rft.aufirst=Laura&rft.date=2008-01-01&rft.volume=43&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fj.1744-6198.2008.00095.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Weight loss; Adherence; Concept analysis; Diet; Exercise; Healthy habits DO - http://dx.doi.org/10.1111/j.1744-6198.2008.00095.x ER - TY - JOUR T1 - Identification of Mold and Dampness-Associated Respiratory Morbidity in 2 Schools: Comparison of Questionnaire Survey Responses to National Data AN - 57294198; 200916752 AB - Background: Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students. Methods: School employees (n = 309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Results: Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections. Conclusions: This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited. Adapted from the source document. JF - Journal of School Health AU - Sahakian, Nancy M AU - White, Sandra K AU - Park, Ju-Hyeong AU - Cox, Jean M AU - Kreiss, Kathleen AD - Medical Officer, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505 nsahakian@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 32 EP - 37 PB - Wiley-Blackwell, UK VL - 78 IS - 1 SN - 0022-4391, 0022-4391 KW - Public schools KW - Dampness KW - Symptoms KW - Environmental health KW - Chronic diseases KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57294198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Identification+of+Mold+and+Dampness-Associated+Respiratory+Morbidity+in+2+Schools%3A+Comparison+of+Questionnaire+Survey+Responses+to+National+Data&rft.au=Sahakian%2C+Nancy+M%3BWhite%2C+Sandra+K%3BPark%2C+Ju-Hyeong%3BCox%2C+Jean+M%3BKreiss%2C+Kathleen&rft.aulast=Sahakian&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=78&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2007.00263.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Symptoms; Dampness; Public schools; Public health; Environmental health; Chronic diseases DO - http://dx.doi.org/10.1111/j.1746-1561.2007.00263.x ER - TY - JOUR T1 - Perspective: Eyes on the prize: Federal Alzheimer's research effort aims to facilitate interventions AN - 57290372; 200915133 AB - The public Alzheimer's disease (AD) research enterprise began in earnest in the mid-1970s with the creation by Congress of the National Institute on Aging at the National Institutes of Health. Today, AD research is a maturing field of study, with federal effort seeking to encourage the creativity and insights of individual investigators, and targeting special areas for emphasis. It is inspired by the legacy of our friend and colleague Leon Thal, whose innovative and collaborative approach to scientific research serves as a guidepost as we move toward the discovery of new and effective ways to prevent AD or slow its progression. This article describes the progress to date and potentially promising areas of study from the vantage point of the National Institute on Aging. [Copyright Elsevier B.V.] JF - Alzheimer's & Dementia AU - Hodes, Richard J AU - Buckholtz, Neil AU - Cahan, Vicky AU - Morrison-Bogorad, Marcelle AD - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA Y1 - 2008/01// PY - 2008 DA - January 2008 SP - S37 EP - S47 PB - Elsevier Ltd, The Netherlands VL - 4 IS - 1S1 SN - 1552-5260, 1552-5260 KW - Alzheimer's disease National Institute on Aging Dementia KW - Ageing KW - Congress KW - Alzheimer's disease KW - Creativity KW - Enterprises KW - Eyes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Perspective%3A+Eyes+on+the+prize%3A+Federal+Alzheimer%27s+research+effort+aims+to+facilitate+interventions&rft.au=Hodes%2C+Richard+J%3BBuckholtz%2C+Neil%3BCahan%2C+Vicky%3BMorrison-Bogorad%2C+Marcelle&rft.aulast=Hodes&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=4&rft.issue=1S1&rft.spage=S37&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2007.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Ageing; Enterprises; Congress; Eyes; Creativity DO - http://dx.doi.org/10.1016/j.jalz.2007.11.002 ER - TY - JOUR T1 - Depression in Public Community Long-Term Care: Implications for Intervention Development AN - 57274785; 200916114 AB - The objective of this paper is to increase understanding of geriatric depression in the public community long-term care system to guide intervention development. Protocols included screening 1,170 new clients of a public community long-term care agency and interviewing all clients with major, dysthymia, or subthreshold depression (n=299) and a randomly selected subset of nondepressed older adults (n=315) at baseline, 6-month, and 1 year. Six percent had major depression, one-half of a percent had dysthymia only, and another 19% had subthreshold depression. Over the year observation period, 40% were persistently depressed; 32% were assessed as depressed only at the first observation; and the remainder was intermittently depressed. There were high levels of comorbid medical, functional, and psychosocial conditions. Mental health service use was low, and clients reported attitudinal and other barriers to depression treatment. Findings suggest the need for universal screening for depression with some strategies for triaging the most severely and persistently depressed for treatment. Although there will be challenges to the development of depression interventions, the public community long-term care system has high potential to assist vulnerable older adults receive help with depression. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Morrow-Howell, Nancy AU - Proctor, Enola AU - Choi, Sunha AU - Lawrence, Lisa AU - Brooks, Ashley AU - Hasche, Leslie AU - Dore, Peter AU - Blinne, Wayne AD - Center for Mental Health Services Research, Washington University, Campus Box 1196, St. Louis, MO 63130, USA morrow-howell@wustl.edu Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 37 EP - 51 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 35 IS - 1 SN - 1094-3412, 1094-3412 KW - Screening KW - Elderly people KW - Depression KW - Long term care KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Depression+in+Public+Community+Long-Term+Care%3A+Implications+for+Intervention+Development&rft.au=Morrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BChoi%2C+Sunha%3BLawrence%2C+Lisa%3BBrooks%2C+Ashley%3BHasche%2C+Leslie%3BDore%2C+Peter%3BBlinne%2C+Wayne&rft.aulast=Morrow-Howell&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=35&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-007-9098-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Long term care; Elderly people; Screening; Comorbidity DO - http://dx.doi.org/10.1007/s11414-007-9098-7 ER - TY - JOUR T1 - Policy and practice implications of epidemiological surveys on co-occurring mental and substance use disorders AN - 57259587; 200813506 AB - This article describes factors that influence national policy and practice, with particular focus on the implications of epidemiological survey research. Examples of areas of concern to policymakers include treatment-seeking patterns, access to care at points of service in public health and social service systems, evidence-based practices, workforce development, and the complexities of reimbursement. In responding to data on systemic barriers to care, the Substance Abuse and Mental Health Services Administration (SAMHSA) has sought to promote a no wrong door strategy to address the needs of persons with co-occurring disorders (CODs) involving their mental health and substance use. Examples of SAMHSA programs and policies addressing CODs discussed in this article include targeted partnerships with the states, mechanisms to enhance system infrastructure, technical assistance, and initiatives with special populations. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Clark, H Westley AU - Power, A Kathryn AU - Le Fauve, Charlene E AU - Lopez, Elizabeth I AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD westley.clark@samhsa.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 3 EP - 13 PB - Elsevier, New York NY VL - 34 IS - 1 SN - 0740-5472, 0740-5472 KW - Co-occurring disorders KW - SAMHSA KW - Epidemiology KW - NSDUH KW - Policy KW - Substance abuse disorders KW - Psychiatric disorders KW - Policy making KW - Comorbidity KW - Evidence based medicine KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57259587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Policy+and+practice+implications+of+epidemiological+surveys+on+co-occurring+mental+and+substance+use+disorders&rft.au=Clark%2C+H+Westley%3BPower%2C+A+Kathryn%3BLe+Fauve%2C+Charlene+E%3BLopez%2C+Elizabeth+I&rft.aulast=Clark&rft.aufirst=H&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.12.032 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance abuse disorders; Comorbidity; Psychiatric disorders; Helpseeking; Evidence based medicine; Policy making DO - http://dx.doi.org/10.1016/j.jsat.2006.12.032 ER - TY - JOUR T1 - The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of new psychiatric diagnostic modules and risk factors in a general population sample AN - 57229447; 200812587 AB - This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factors for alcohol, drug, and psychiatric disorders from the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1899 adults selected from 34,653 respondents who participated in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa>0.63; ICC>0.69; alpha>0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations=0.50-0.94; alpha=0.64-0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors for alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ruan, W June AU - Goldstein, Rise B AU - Chou, S Patricia AU - Smith, Sharon M AU - Saha, Tulshi D AU - Pickering, Roger P AU - Dawson, Deborah A AU - Huang, Boji AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, United States Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 27 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 92 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Reliability KW - Alcohol and drug use disorders KW - Risk factors KW - Test-retest reliability KW - General population KW - Internal consistency KW - Diagnostic testing KW - Test-Retest reliability KW - Psychiatric disorders KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57229447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+Alcohol+Use+Disorder+and+Associated+Disabilities+Interview+Schedule-IV+%28AUDADIS-IV%29%3A+Reliability+of+new+psychiatric+diagnostic+modules+and+risk+factors+in+a+general+population+sample&rft.au=Ruan%2C+W+June%3BGoldstein%2C+Rise+B%3BChou%2C+S+Patricia%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BDawson%2C+Deborah+A%3BHuang%2C+Boji%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Ruan&rft.aufirst=W&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.06.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Diagnostic testing; Reliability; Psychiatric disorders; Alcohol related disorders; Risk factors; Test-Retest reliability DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.06.001 ER - TY - JOUR T1 - Reinforcing coal mine roof with polyurethane injection; 4 case studies AN - 50539003; 2009-006474 JF - Geotechnical and Geological Engineering AU - Molinda, Gregory Y1 - 2008 PY - 2008 DA - 2008 SP - 553 EP - 566 PB - Springer, Dordrecht VL - 26 IS - 5 SN - 0960-3182, 0960-3182 KW - United States KW - mining KW - mines KW - underground mining KW - roof control KW - video methods KW - reinforced materials KW - rock mechanics KW - case studies KW - sedimentary rocks KW - mining geology KW - coal KW - West Virginia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50539003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geotechnical+and+Geological+Engineering&rft.atitle=Reinforcing+coal+mine+roof+with+polyurethane+injection%3B+4+case+studies&rft.au=Molinda%2C+Gregory&rft.aulast=Molinda&rft.aufirst=Gregory&rft.date=2008-01-01&rft.volume=26&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Geotechnical+and+Geological+Engineering&rft.issn=09603182&rft_id=info:doi/10.1007%2Fs10706-008-9189-0 L2 - http://www.springerlink.com/app/home/journal.asp?wasp=f656ca91cf3b40e8868983de406060e5&referrer=parent&backto=linkingpublicationresults,1:100171,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - case studies; coal; mines; mining; mining geology; reinforced materials; rock mechanics; roof control; sedimentary rocks; underground mining; United States; video methods; West Virginia DO - http://dx.doi.org/10.1007/s10706-008-9189-0 ER - TY - JOUR T1 - Projecting long term medical spending growth AN - 36794457; 3491073 AB - We present a dynamic general equilibrium model of the U.S. economy and the medical sector in which the adoption of new medical treatments is endogenous and the demand for medical services is conditional on the state of technology. We use this model to prepare 75-year medical spending forecasts and a projection of the Medicare actuarial balance, and we compare our results to those obtained from a method that has been used by government actuaries. Our baseline forecast predicts slower health spending growth in the long run and a lower Medicare actuarial deficit relative to the previous projection methodology. All rights reserved, Elsevier JF - Journal of health economics AU - Borger, C AU - Rutherford, T F AU - Won, Gregory Y AD - US Department of Health and Human Services Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 69 EP - 88 VL - 27 IS - 1 SN - 0167-6296, 0167-6296 KW - Economics KW - Medicare KW - Medical care KW - Public expenditure KW - Economic forecasts KW - Health policy KW - General economic equilibrium KW - U.S.A. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36794457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+economics&rft.atitle=Projecting+long+term+medical+spending+growth&rft.au=Borger%2C+C%3BRutherford%2C+T+F%3BWon%2C+Gregory+Y&rft.aulast=Borger&rft.aufirst=C&rft.date=2008-01-01&rft.volume=27&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+economics&rft.issn=01676296&rft_id=info:doi/10.1016%2Fj.jhealeco.2007.03.003 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3937 5163; 5788 11888 10472; 5436 4375; 7875 5775 13521; 10443 4618; 433 293 14 DO - http://dx.doi.org/10.1016/j.jhealeco.2007.03.003 ER - TY - JOUR T1 - Emerging Enteric and Potentially Waterborne Pathogens AN - 21241382; 11188379 AB - Infectious water-borne pathogens are a major cause of morbidity and mortality. A substantial proportion of water-borne disease is caused by established pathogens. However, emerging pathogens present important challenges to the water and health sectors. The last 30 to 40 years has seen the initial identification of a number of significant pathogens that can be water-borne including rotavirus, norovirus, V.cholerae 0139, Cryptosporidium, Campylobacter and Legionella. Many more are classified as emerging due to detection of increased incidence of disease or detection in areas where they were not previously established. The emergence of infectious diseases, including those that are water-borne, is caused by a number of factors such as population growth, migration, travel, new environments, climate change, improved methodology and drug resistance. Understanding these factors is an important component of establishing effective management of water resources and drinking water safety plans. JF - Water Practice and Technology AU - Cunliffe, DA AD - Public Health Service, Department of Health, PO Box 6, Rundle Mall, South Australia 5001, david.cunime@health.sa.gov.au Y1 - 2008 PY - 2008 DA - 2008 VL - 3 IS - 4 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - Rotavirus KW - Travel KW - Population growth KW - Drug resistance KW - Viruses KW - Climatic changes KW - Water resources KW - Migration KW - Morbidity KW - Drinking Water KW - Infectious diseases KW - Water-borne diseases KW - Climatic Changes KW - Diseases KW - Legionella KW - Mortality KW - Campylobacter KW - Norovirus KW - Pathogens KW - Cryptosporidium KW - Drinking water KW - AQ 00001:Water Resources and Supplies KW - V 22300:Methods KW - SW 0810:General KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21241382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Practice+and+Technology&rft.atitle=Emerging+Enteric+and+Potentially+Waterborne+Pathogens&rft.au=Cunliffe%2C+DA&rft.aulast=Cunliffe&rft.aufirst=DA&rft.date=2008-01-01&rft.volume=3&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+Practice+and+Technology&rft.issn=&rft_id=info:doi/10.2166%2Fwpt.2008.092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Travel; Mortality; Infectious diseases; Drug resistance; Population growth; Climatic changes; Water-borne diseases; Water resources; Pathogens; Drinking water; Migration; Morbidity; Drinking Water; Viruses; Cryptosporidium; Climatic Changes; Diseases; Rotavirus; Campylobacter; Norovirus; Legionella DO - http://dx.doi.org/10.2166/wpt.2008.092 ER - TY - BOOK T1 - Effects of Microbiota on GI Health: Gnotobiotic Research AN - 21239439; 11277202 AB - The complex interactions between the GI tract microbiota and the immune system can be simplified for study using gnotobiotic animal models. The importance of cytokines, such as IFN-*g, TNF-*a, TGF-*b, Interleukin-2, IL-4 and IL-10 in the host response to intestinal bacteria has been evaluated using gnotobiotic studies. Gnotobiotic experiments with immunodeficient animals have revealed insights into the relationships between innate, cell-mediated and antibody-mediated immune system components in resistance to infectious microorganisms. The development and maturation of the immune system is dependent on the presence of some members of the intestinal microbiota. The commensal microorganisms, in turn, are dependent on the environment and nutrients provided by the GI tract of the host. Gnotobiotic studies are starting to reveal how the microbiota influences oral tolerance to dietary and commensal bacterial antigens. The immunomodulatory effects of microbiota and probiotics for inflammatory bowel diseases and the role of bacteria in their etiologies are being studied in gnotobiotic systems. Many aspects of the host interaction with the microbiota have been and will continue to be best addressed in gnotobiotic experimental models. This chapter reviews the contributions that gnotobiology has made to our understanding of the microbiota and host GI tract health. JF - Advances in Experimental Medicine and Biology AU - Wagner, Robert Doug A2 - Huffnagle, Gary B A2 - Noverr, Mairi C (Eds) Y1 - 2008 PY - 2008 DA - 2008 SP - 16 EP - 56 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany SN - 9780387799896 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Interleukin 4 KW - Etiology KW - Interleukin 2 KW - Immune system KW - Immunodeficiency KW - Animal models KW - probiotics KW - Commensals KW - Nutrients KW - Immunomodulation KW - Immunological tolerance KW - Interleukin 10 KW - Oral cavity KW - Intestinal microflora KW - Inflammatory bowel diseases KW - Microorganisms KW - Gnotobiotics KW - Intestine KW - Gastrointestinal tract KW - A 01330:Food Microbiology KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21239439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wagner%2C+Robert+Doug&rft.aulast=Wagner&rft.aufirst=Robert&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=41&rft.isbn=9780387799896&rft.btitle=Effects+of+Microbiota+on+GI+Health%3A+Gnotobiotic+Research&rft.title=Effects+of+Microbiota+on+GI+Health%3A+Gnotobiotic+Research&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-0-387-09550-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 DO - http://dx.doi.org/10.1007/978-0-387-09550-9 ER - TY - JOUR T1 - Functional role of Trp-105 of Enterococcus faecalis azoreductase (AzoA) as resolved by structural and mutational analysis AN - 21051867; 8470153 AB - Enterococcus faecalis azoreductase (AzoA) is a very active enzyme with a broad spectrum of substrate specificity and is capable of degrading various azo dyes. The enzyme has an absolute requirement for reduced FMN, which delivers a total of four electrons from NADH to the substrate, resulting in the cleavage of the nitrogen double bond. In this study, we report the identification of amino acid residues critical for FMN binding in AzoA. FMN is stabilized by 22 amino acid residues, eight of which, Trp-105, Asn-106, Leu-107, Gly-150, Gly-151, Tyr-153, Asn-121 and Tyr-129, are involved in binding the FMN isoalloxazine ring. In silico analysis of the amino acid residues revealed that the Trp residue at position 105 of AzoA is the most likely significant contributor to the binding of FMN to the enzyme and is involved in FMN stabilization and destabilization. Site-directed mutagenesis analysis of Trp-105 was performed to determine the role of this amino acid residue in FMN binding and azo dye reductive activity. The mutant proteins were overexpressed in Escherichia coli and purified by anion- exchange and size-exclusion chromatography. The replacement of Trp-105 by the small side-chain amino acids Ala and Gly caused complete loss of both affinity for FMN and enzyme activity. Substitution of Tyr for Trp-105 did not significantly decrease the V sub(max) of the enzyme (22 % reduction). Substitutions with three bulky side-chain amino acids, Gln, Phe and His, produced enzymes with lower V sub(max) values (decreases of 68.2, 30.6 and 8.2-fold, respectively). However, these mutated enzymes maintained K sub(m) values similar to the wild-type enzyme. This study provides an insight into the catalytic properties of AzoA in FMN stabilization and enzyme activity. JF - Microbiology AU - Chen, Huizhong AU - Xu, Haiyan AU - Kweon, Ohgew AU - Chen, Siwei AU - Cerniglia, Carl E Y1 - 2008 PY - 2008 DA - 2008 SP - 2659 EP - 2667 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 154 IS - 9 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Site-directed mutagenesis KW - Amino acids KW - Amino acid substitution KW - Chromatography KW - Azo dyes KW - NADH KW - Enterococcus faecalis KW - Enzymes KW - Substrate specificity KW - Flavin mononucleotide KW - Escherichia coli KW - Azoreductase KW - Nitrogen KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21051867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Functional+role+of+Trp-105+of+Enterococcus+faecalis+azoreductase+%28AzoA%29+as+resolved+by+structural+and+mutational+analysis&rft.au=Chen%2C+Huizhong%3BXu%2C+Haiyan%3BKweon%2C+Ohgew%3BChen%2C+Siwei%3BCerniglia%2C+Carl+E&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2008-01-01&rft.volume=154&rft.issue=9&rft.spage=2659&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.2008%2F019877-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Amino acid substitution; Amino acids; Azo dyes; Chromatography; NADH; Substrate specificity; Enzymes; Flavin mononucleotide; Azoreductase; Nitrogen; Escherichia coli; Enterococcus faecalis DO - http://dx.doi.org/10.1099/mic.0.2008/019877-0 ER - TY - JOUR T1 - Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559 AN - 21043404; 8580666 AB - A clinical strain of Enterococcus faecium ATCC 51559 exhibits heteroresistance, i.e. a high level of resistance to vancomycin (minimum inhibitory concentration (MIC) > 256 kg/mL) by broth dilution but sensitivity to vancomycin by Etest (MIC = 1.8 kg/mL). Three variants of this strain, EF1, EF2 and EF3, exhibit high levels of resistance to vancomycin both by broth dilution and Etest assays. The four strains were used to study heteroresistance by pulsed-field gel electrophoresis (PFGE), polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequence analysis of a partial region of the van operon. Minor differences between SalI and SmaI restriction profiles of the variants and the parental strain were observed by PFGE analysis. PCR analysis confirmed the presence of the vancomycin resistance marker vanA (0.73 kb) and a larger than expected amplicon (8.2 kb vs. 6.7 kb) of the van operon in all the strains. The 8.2 kb van operon was cloned for EcoRI RFLP and sequence analysis. All of the clones exhibited distinctly different RFLP profiles when grown in the presence of kanamycin or vancomycin + kanamycin. The presence of these antibiotics during overnight growth of EF1 on plates also resulted in altered SalI PFGE profiles. Sequence analysis of the van operon clones revealed a 1.5 kb IS1251-like insertion element between the vanS and vanH genes in all the strains. Several novel point mutations in the vanR, vanS, vanH, vanA, vanX and vanY genes were also discovered. Some of these mutations were present in the parental strain only and included base substitutions T --> C, A --> G, T --> A and T - -> C at nucleotide positions 4202, 4597, 4763 and 6207 of Tn1546, resulting in amino acid replacements I76 --> T and K208 --> E of vanR, S19 --> T of vanS and L64 --> P of vanH genes, respectively. We believe that these are responsible for the observed heteroresistance. The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin- resistant enterococci strains as a result of continuous exposure to antibiotics. JF - International Journal of Antimicrobial Agents AU - Khan, Saeed A AU - Sung, Kidon AU - Layton, Sherryll AU - Nawaz, Mohamed S AD - Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, saeed.khan@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 27 EP - 36 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 31 IS - 1 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology KW - Vancomycin-resistant enterococci KW - Polymerase chain reaction KW - Restriction fragment length polymorphism KW - Pulsed-field gel electrophoresis KW - Insertion element KW - Amino acids KW - Amino acid substitution KW - Point mutation KW - Antibiotics KW - Kanamycin KW - Minimum inhibitory concentration KW - Nucleotides KW - Enterococcus faecium KW - Vancomycin KW - Operons KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21043404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Heteroresistance+to+vancomycin+and+novel+point+mutations+in+Tn1546+of+Enterococcus+faecium+ATCC+51559&rft.au=Khan%2C+Saeed+A%3BSung%2C+Kidon%3BLayton%2C+Sherryll%3BNawaz%2C+Mohamed+S&rft.aulast=Khan&rft.aufirst=Saeed&rft.date=2008-01-01&rft.volume=31&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2007.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Amino acids; Point mutation; Pulsed-field gel electrophoresis; Restriction fragment length polymorphism; Polymerase chain reaction; Vancomycin; Kanamycin; Antibiotics; Operons; Minimum inhibitory concentration; Nucleotides; Enterococcus faecium DO - http://dx.doi.org/10.1016/j.ijantimicag.2007.08.007 ER - TY - JOUR T1 - Problems of groundwater management and the need for its inclusion in the Brazilian national model of integrated water resources management AN - 21021577; 8190738 AB - This paper discusses certain issues related to groundwater management within the context of the Brazilian national policy for water resources management. In order to investigate the importance of this water supply source, we interviewed groundwater users in the city of Sao Paulo, where some 57% of the total water supply comes from this source, and surveyed some of the factors affecting the use of this alternative. These include the existence of a good supply of groundwater, an inadequate public water supply system unable to meet user demands, the degradation of fresh water sources and the reduction in costs involved. Preliminary conclusions suggest the inadequacy of the present system of water resources management, which has not yet integrated the use of groundwater reserves into an overall national program for water resources management. JF - Water Policy AU - Rodrigues, FdA AU - Pereira, SY AD - Department of Geology and Natural Resources, State University of Campinas, 51 Pandia Calogeras, Campinas, SP, P.A. 13083 - 970, Brazil, assis@ige.unicamp.br Y1 - 2008 PY - 2008 DA - 2008 SP - 165 EP - 171 VL - 10 IS - 2 SN - 1366-7017, 1366-7017 KW - Pollution Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Degradation KW - Water Costs KW - Groundwater management KW - Water Supply KW - Water resources KW - Public Waters KW - Water Resources Management KW - Water supplies KW - Potential resources KW - Water Policy KW - Ground water KW - Water sources KW - Groundwater Management KW - Urban areas KW - Modelling KW - water policy KW - Water resources management KW - Policies KW - Model Studies KW - Water supply KW - Brazil, Sao Paulo KW - Water management KW - Groundwater KW - Water policy KW - Q2 09122:Legislation KW - P 2000:FRESHWATER POLLUTION KW - M3 1010:Issues in Sustainable Development KW - M2 556.18:Water Management (556.18) KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21021577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Policy&rft.atitle=Problems+of+groundwater+management+and+the+need+for+its+inclusion+in+the+Brazilian+national+model+of+integrated+water+resources+management&rft.au=Rodrigues%2C+FdA%3BPereira%2C+SY&rft.aulast=Rodrigues&rft.aufirst=FdA&rft.date=2008-01-01&rft.volume=10&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Water+Policy&rft.issn=13667017&rft_id=info:doi/10.2166%2Fwp.2008.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Policies; Potential resources; Water management; Ground water; Water resources; Modelling; Water policy; Water supply; Water resources management; Groundwater management; Water sources; water policy; Degradation; Groundwater; Water supplies; Urban areas; Water Policy; Water Costs; Water Supply; Public Waters; Water Resources Management; Groundwater Management; Model Studies; Brazil, Sao Paulo DO - http://dx.doi.org/10.2166/wp.2008.038 ER - TY - JOUR T1 - Reducing Commercial Fishing Deck Hazards with Engineering Solutions for Winch Design AN - 21020455; 8549651 AB - Introduction The majority (67%) of hospitalized injuries among Alaska commercial fishermen are associated with deck machinery. This paper describes the 'Prevention Through Design' process to mitigate one serious machinery entanglement hazard posed by a capstan deck winch. Methods After observing that the capstan winch provides no entanglement protection and the hydraulic controls are usually out of reach of the entangled person, NIOSH personnel met with fishermen and winch manufacturers to discuss various design solutions to mitigate these hazards. Results An emergency-stop ('e-stop') system was developed that incorporated a momentary contact button that when pushed, switches a safety-relay that de-energizes the solenoid of an electro-hydraulic valve stopping the rotating winch. The vessel owners that had the e-stop installed enthusiastically recommend it to other fishermen. NIOSH entered into a Proprietary Technology Licensing Agreement with a company to develop the system for commercial use. Conclusions This is an example of a practical engineering control that effectively protects workers from a hazardous piece of equipment by preventing injuries due to entanglement. This solution could reduce these types of debilitating injuries and fatalities in this industry. JF - Journal of Safety Research AU - Lincoln, Jennifer M AU - Lucas, Devin L AU - McKibbin, Robert W AU - Woodward, Chelsea C AU - Bevan, John E AD - NIOSH Alaska Field Station, Anchorage Alaska, jlincoln@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 231 EP - 235 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Hydraulics KW - Injuries KW - Occupational safety KW - Licensing KW - Hazards KW - Commercial fishing KW - Machinery KW - prevention KW - USA, Alaska KW - Mortality KW - Design KW - safety engineering KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21020455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Reducing+Commercial+Fishing+Deck+Hazards+with+Engineering+Solutions+for+Winch+Design&rft.au=Lincoln%2C+Jennifer+M%3BLucas%2C+Devin+L%3BMcKibbin%2C+Robert+W%3BWoodward%2C+Chelsea+C%3BBevan%2C+John+E&rft.aulast=Lincoln&rft.aufirst=Jennifer&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Alaska; Injuries; Machinery; safety engineering; Design; Licensing; Mortality; Commercial fishing; Hydraulics; prevention; Technology; Occupational safety; Hazards DO - http://dx.doi.org/10.1016/j.jsr.2008.02.027 ER - TY - JOUR T1 - McCune-Albright syndrome AN - 20996797; 8519422 AB - McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), cafe-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common and may be progressive. In addition to PP (vaginal bleeding or spotting and development of breast tissue in girls, testicular and penile enlargement and precocious sexual behavior in boys), other hyperfunctioning endocrinopathies may be involved including hyperthyroidism, growth hormone excess, Cushing syndrome, and renal phosphate wasting. Cafe-au-lait spots usually appear in the neonatal period, but it is most often PP or FD that brings the child to medical attention. Renal involvement is seen in approximately 50% of the patients with MAS. The disease results from somatic mutations of the GNAS gene, specifically mutations in the cAMP regulating protein, G sub(s )alpha. The extent of the disease is determined by the proliferation, migration and survival of the cell in which the mutation spontaneously occurs during embryonic development. Diagnosis of MAS is usually established on clinical grounds. Plain radiographs are often sufficient to make the diagnosis of FD and biopsy of FD lesions can confirm the diagnosis. The evaluation of patients with MAS should be guided by knowledge of the spectrum of tissues that may be involved, with specific testing for each. Genetic testing is possible, but is not routinely available. Genetic counseling, however, should be offered. Differential diagnoses include neurofibromatosis, osteofibrous dysplasia, non-ossifying fibromas, idiopathic central precocious puberty, and ovarian neoplasm. Treatment is dictated by the tissues affected, and the extent to which they are affected. Generally, some form of surgical intervention is recommended. Bisphosphonates are frequently used in the treatment of FD. Strengthening exercises are recommended to help maintaining the musculature around the FD bone and minimize the risk for fracture. Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS. JF - Orphanet Journal of Rare Diseases AU - Dumitrescu, Claudia E AU - Collins, Michael T AD - Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, mosteanuc@nidcr.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - BioMed Central Ltd., Middlesex House VL - 3 SN - 1750-1172, 1750-1172 KW - Risk Abstracts KW - sexual behavior KW - pain KW - Hormones KW - surgery KW - risk reduction KW - genetic screening KW - intervention KW - enlargement KW - Lesions KW - plains KW - migration KW - Skin KW - Bone KW - Phosphates KW - Proteins KW - Neonates KW - survival KW - Mutation KW - bisphosphonates KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20996797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orphanet+Journal+of+Rare+Diseases&rft.atitle=McCune-Albright+syndrome&rft.au=Dumitrescu%2C+Claudia+E%3BCollins%2C+Michael+T&rft.aulast=Dumitrescu&rft.aufirst=Claudia&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Orphanet+Journal+of+Rare+Diseases&rft.issn=17501172&rft_id=info:doi/10.1186%2F1750-1172-3-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mutation; genetic screening; Bone; Lesions; sexual behavior; Phosphates; risk reduction; Hormones; enlargement; intervention; bisphosphonates; surgery; pain; survival; migration; Proteins; plains; Skin; Neonates DO - http://dx.doi.org/10.1186/1750-1172-3-12 ER - TY - JOUR T1 - Intervention Effectiveness Evaluation Criteria: Promoting Competitions and Raising the Bar AN - 20978282; 8549422 AB - The Intervention Evaluation Competition at the Work, Stress, and Health conference in Miami (March 2006) highlighted the importance of intervention evaluation studies that promote safety and health at work. A retitled, 'Best Practices Evaluation Competition,' has been included in the March, 2008, Work, Stress, and Health conference, in Washington, DC. This brief note describes the development of the criteria used to evaluate the manuscripts. The criteria are discussed with respect to (a) improving the science of evaluation methodology, (b) promoting the highest ethical standards in intervention evaluation, and (c) using the current criteria as a starting point for continuing to raise the bar for evaluation methodology. The policy implications of the evaluation criteria are discussed as well. JF - Journal of Occupational Health Psychology AU - Scharf, Ted AU - Chapman, Larry AU - Collins, Jim AU - Limanowski, Julia AU - Heaney, Cathy AU - Goldenhar, Linda M AD - Division of Applied Research and Technology, NIOSH, Cincinnati, Ohio, tscharf@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1 EP - 9 PB - American Psychological Association, 750 First St., N.E. Washington DC 20002-4242 USA, [mailto:journals@apa.org], [URL:http://www.apa.org/] VL - 13 IS - 1 SN - 1076-8998, 1076-8998 KW - Health & Safety Science Abstracts KW - Conferences KW - Occupational safety KW - Stress KW - best practices KW - Ethics KW - intervention KW - USA, Florida, Miami KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health+Psychology&rft.atitle=Intervention+Effectiveness+Evaluation+Criteria%3A+Promoting+Competitions+and+Raising+the+Bar&rft.au=Scharf%2C+Ted%3BChapman%2C+Larry%3BCollins%2C+Jim%3BLimanowski%2C+Julia%3BHeaney%2C+Cathy%3BGoldenhar%2C+Linda+M&rft.aulast=Scharf&rft.aufirst=Ted&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health+Psychology&rft.issn=10768998&rft_id=info:doi/10.1037%2F1076-8998.13.1.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Florida, Miami; intervention; Occupational health; Stress; Conferences; best practices; Occupational safety; Ethics DO - http://dx.doi.org/10.1037/1076-8998.13.1.1 ER - TY - JOUR T1 - Prevention through Design - Introduction AN - 20975050; 8549623 AB - Abstract not available. JF - Journal of Safety Research AU - Howard, John AD - Director, National Institute for Occupational Safety and Health, jhoward1@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 113 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20975050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Prevention+through+Design+-+Introduction&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.022 ER - TY - RPRT T1 - A Tree Trimmer Dies When He is Pulled into a Wood Chipper AN - 20967607; 11069910 AB - A Hispanic male tree trimmer died after he was pulled into a wood chipper while feeding branches into the machine. The victim was part of a two-man crew that was trimming trees along a residential street when the incident occurred. The wood chipper had a built-in safety device called the feed control bar that was located on the top and both sides of the feed chute, however it is not known if it was working at the time of the incident. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP), should: Ensure that employees never operate a wood chipper alone. Ensure that all employees stand to the side of the feed table when feeding trimmings into the wood chipper. Ensure that employees are thoroughly trained and tested on the operation of wood chippers. Ensure that a documented inspection report is completed every time a wood chipper is used and kept on file. JF - A Tree Trimmer Dies When He is Pulled into a Wood Chipper. [np]. 2008. AU - Anonymous Y1 - 2008 PY - 2008 DA - 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Trees KW - feeding KW - Wood KW - inspection KW - prevention KW - Ethnic groups KW - Feeds KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.title=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A biocompatible medium for nanoparticle dispersion AN - 20944856; 8493288 AB - Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a 'lung fluid mimic'. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies. JF - Nanotoxicology AU - Porter, D AU - Sriram, K AU - Wolfarth, M AU - Jefferson, A AU - Schwegler-Berry, D AU - Andrew, ME AU - Castranova, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 144 EP - 154 VL - 2 IS - 3 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Biocompatibility KW - Transmission electron microscopy KW - Brain KW - Light scattering KW - Toxicity KW - Dispersants KW - Alveoli KW - Standardization KW - Titanium dioxide KW - Silica KW - Carbon KW - Bronchus KW - Lung KW - nanotubes KW - nanoparticles KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=A+biocompatible+medium+for+nanoparticle+dispersion&rft.au=Porter%2C+D%3BSriram%2C+K%3BWolfarth%2C+M%3BJefferson%2C+A%3BSchwegler-Berry%2C+D%3BAndrew%2C+ME%3BCastranova%2C+V&rft.aulast=Porter&rft.aufirst=D&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318349 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biocompatibility; Transmission electron microscopy; Light scattering; Brain; Toxicity; Dispersants; Alveoli; Standardization; Carbon; Silica; Titanium dioxide; Bronchus; Lung; nanotubes; nanoparticles DO - http://dx.doi.org/10.1080/17435390802318349 ER - TY - JOUR T1 - A regulatory viewpoint on transporter-based drug interactions AN - 20937743; 8493298 AB - 1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation of a new molecular entity's (NME) drug-drug interaction potential is an integral part of drug development and regulatory review before its market approval. Clinically relevant interactions mediated by transporters are of increasing interest in clinical development and research in this emerging area and it has been revealed that drug transporters can play an important role in modulating drug absorption, distribution, metabolism and elimination. 2. Acting alone or in concert with drug-metabolizing enzymes transporters can affect the pharmacokinetics and/or pharmacodynamics of a drug. The newly released drug interaction guidance by the US Food and Drug Administration (USFDA) includes new information addressing drug transporter interactions with a primary focus on P-glycoprotein (P-gp, ABCB1). 3. This paper provides a regulatory viewpoint on transporters and their potential role in drug-drug interactions. It first outlines information that might be needed during drug development and ultimately included in new drug application (NDA) submissions to address potential transporter-mediated drug interactions. Next, it explains criteria that may warrant conduct of in vivo P-gp-mediated drug interaction studies based on in vitro assessment. In addition, it includes a review case that describes the evaluation of data suggesting a P-gp-based induction interaction. JF - Xenobiotica AU - Zhang, L AU - Zhang, Y AU - Strong, J M AU - Reynolds, K S AU - Huang, S-M AD - Offices of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 709 EP - 724 VL - 38 IS - 7/8 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Drug interaction KW - P-Glycoprotein KW - Data processing KW - Reviews KW - Drug metabolism KW - Enzymes KW - Drug development KW - Pharmacokinetics KW - Pharmacodynamics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20937743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=A+regulatory+viewpoint+on+transporter-based+drug+interactions&rft.au=Zhang%2C+L%3BZhang%2C+Y%3BStrong%2C+J+M%3BReynolds%2C+K+S%3BHuang%2C+S-M&rft.aulast=Zhang&rft.aufirst=L&rft.date=2008-01-01&rft.volume=38&rft.issue=7%2F8&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250802017715 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug interaction; P-Glycoprotein; Data processing; Drug metabolism; Reviews; Enzymes; Drug development; Pharmacodynamics; Pharmacokinetics DO - http://dx.doi.org/10.1080/00498250802017715 ER - TY - JOUR T1 - Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction AN - 20929287; 8173930 AB - Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. PAHs also stimulate their own metabolism by inducing CYP1A1. Recent studies suggest that respirable coal dust exposure inhibits induction of pulmonary CYP1A1 using the model PAH beta -naphthoflavone. The effect of the occupational particulate respirable crystalline silica was investigated on PAH-dependent pulmonary CYP1A1 induction. Male Sprague-Dawley rats were exposed to intratracheal silica or vehicle and then intraperitoneal beta -naphthoflavone, a CYP1A1 inducer, and/or phenobarbital, an inducer of hepatic CYP2B1, or vehicle. beta -Naphthoflavone induced pulmonary CYP1A1, but silica attenuated this beta -naphthoflavone-induced CYP1A1 activity and also suppressed the activity of CYP2B1, the major constitutive CYP in rat lung. The magnitude of CYP activity suppression was similar regardless of silica exposure dose within a range of 5 to 20 mg/rat. Phenobarbital and beta -naphthoflavone had no effect on pulmonary CYP2B1 activity. Both enzymatic immunohistochemistry and immunofluorescent staining for CYP1A1 indicated that sites of CYP1A1 induction were nonciliated airway epithelial cells, endothelial cells, and the alveolar septum. Using immunofluorescent colocalization of CYP1A1 with cytokeratin 8, a marker of alveolar type II cells, the proximal alveolar region was the site of both increased alveolar type II cells and decreased proportional CYP1A1 expression in alveolar type II cells. Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Battelli, LA AU - Ghanem, M M AU - Kashon, M L AU - Barger, M AU - Ma, JYC AU - Simoskevitz, R L AU - Miles, PR AU - Hubbs, A F AD - CDC/NIOSH, 1095 Willowdale Road, M/S L2015, Morgantown, WV 26505, USA, LBattelli@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 521 EP - 532 VL - 71 IS - 7-8 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - Epithelial cells KW - Cytochromes KW - Phenobarbital KW - Polycyclic aromatic hydrocarbons KW - Carcinogens KW - Alveoli KW - Combustion KW - Endothelial cells KW - Workers KW - beta -Naphthoflavone KW - Silica KW - Lung KW - Liver KW - Excretion KW - Coal dust KW - Cytochrome P450 KW - Septum KW - Trachea KW - Immunohistochemistry KW - Metabolism KW - Cytokeratin KW - Respiratory tract KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20929287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Crystalline+Silica+is+a+Negative+Modifier+of+Pulmonary+Cytochrome+P-4501A1+Induction&rft.au=Battelli%2C+LA%3BGhanem%2C+M+M%3BKashon%2C+M+L%3BBarger%2C+M%3BMa%2C+JYC%3BSimoskevitz%2C+R+L%3BMiles%2C+PR%3BHubbs%2C+A+F&rft.aulast=Battelli&rft.aufirst=LA&rft.date=2008-01-01&rft.volume=71&rft.issue=7-8&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390801907483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytochromes; Epithelial cells; Polycyclic aromatic hydrocarbons; Phenobarbital; Carcinogens; Alveoli; Combustion; Endothelial cells; Workers; Silica; beta -Naphthoflavone; Lung; Liver; Coal dust; Excretion; Septum; Cytochrome P450; Immunohistochemistry; Trachea; Metabolism; Respiratory tract; Cytokeratin DO - http://dx.doi.org/10.1080/15287390801907483 ER - TY - JOUR T1 - Chemical Imaging of Pharmaceutical Materials: Fabrication of Micropatterned Resolution Targets AN - 20916306; 8424022 AB - Resolution targets composed of thick poly(ethylene glycol) (PEG) lines on silicon substrates have been fabricated using the method of micromolding in capillaries (MiMIC). Patterns of three parallel lines with equal width and spacing have been prepared, with widths between 5 and 25 mu m. Raman chemical images of the PEG-on-silicon devices as well as the metal-on-glass masks used to prepare the devices were measured. The Raman images were used to determine the impulse response of the instrument by comparing the measured images to model functions prepared by convolution of a test impulse function with the object functions of the devices. Impulse widths for PEG-on-silicon targets were approximately two times greater than impulse widths for metal-on-glass targets. The results provide a quantitative measure of the influence of light-matter interactions on the spatial resolution achievable with chemical imaging instruments. This work shows that microfluidic channels can be used to produce robust patterns of PEG on silicon, and these patterns are realistic resolution targets for spectroscopic chemical imaging of pharmaceutical materials. JF - Analytical Chemistry (Washington) AU - Gilliam, Sean J AU - Martin, RScott AU - Kauffman, John F AD - Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101 Y1 - 2008 PY - 2008 DA - 2008 SP - 5706 EP - 5712 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 15 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Microfluidics KW - Pharmaceuticals KW - spatial discrimination KW - imaging KW - Polyethylene glycol KW - Capillaries KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20916306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Chemical+Imaging+of+Pharmaceutical+Materials%3A+Fabrication+of+Micropatterned+Resolution+Targets&rft.au=Gilliam%2C+Sean+J%3BMartin%2C+RScott%3BKauffman%2C+John+F&rft.aulast=Gilliam&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=80&rft.issue=15&rft.spage=5706&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac800864x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Microfluidics; Silicon; Pharmaceuticals; spatial discrimination; Capillaries; Polyethylene glycol; imaging; Models DO - http://dx.doi.org/10.1021/ac800864x ER - TY - JOUR T1 - Projected Cost-effectiveness of New Vaccines for Adolescents in the United States AN - 20892463; 7937049 AB - BACKGROUND. Economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. However, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood. OBJECTIVE. Our goal was to examine economic studies of adolescent vaccines and compare cost-effectiveness outcomes among studies on a particular vaccine, across adolescent vaccines, and between new adolescent vaccines versus vaccines that are recommended for young children. METHODS. A systematic review of economic studies on immunizations for adolescents was conducted. Studies were identified by searching the Medline, Embase, and EconLit databases. Each study was reviewed for appropriateness of model design, baseline setup, sensitivity analyses, and input variables (ie, epidemiologic, clinical, cost, and quality-of-life impact). For comparison, the cost-effectiveness outcomes reported in key studies on vaccines for younger children were selected. RESULTS. Vaccines for healthy adolescents were consistently found to be more costly than the health care or societal cost savings they produced and, in general, were less cost-effective than vaccines for younger children. Among the new vaccines, pertussis and human papillomavirus vaccines were more cost-effective than meningococcal vaccines. Including herd-immunity benefits in studies significantly improved the cost-effectiveness estimates for new vaccines. Differences in measurements or assumptions limited further comparisons. CONCLUSION. Although using the new adolescent vaccines is unlikely to be cost-saving, vaccination programs will result in sizable health benefits. JF - Pediatrics AU - Ortega-Sanchez, Ismael R AU - Lee, Grace M AU - Jacobs, RJake AU - Prosser, Lisa A AU - Molinari, Noelle-Angelique AU - Zhang, Xinzhi AU - Baine, William B AU - McCauley, Mary M AU - Miller, Ted AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts. Division of Infectious Diseases, Children's Hospital Boston, Boston, Massachusetts. Capitol Outcomes Research, Inc, Alexandria, Virginia. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland. Pacific Institute for Research and Evaluation, Calverton, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - S63 EP - S78 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - Supplement_1 SN - 0031-4005, 0031-4005 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Pertussis KW - Adolescence KW - Reviews KW - Economics KW - Neisseria meningitidis KW - Vaccines KW - Children KW - Human papillomavirus KW - Models KW - F 06905:Vaccines KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Projected+Cost-effectiveness+of+New+Vaccines+for+Adolescents+in+the+United+States&rft.au=Ortega-Sanchez%2C+Ismael+R%3BLee%2C+Grace+M%3BJacobs%2C+RJake%3BProsser%2C+Lisa+A%3BMolinari%2C+Noelle-Angelique%3BZhang%2C+Xinzhi%3BBaine%2C+William+B%3BMcCauley%2C+Mary+M%3BMiller%2C+Ted&rft.aulast=Ortega-Sanchez&rft.aufirst=Ismael&rft.date=2008-01-01&rft.volume=121&rft.issue=Supplement_1&rft.spage=S63&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Databases; Reviews; Adolescence; Economics; Vaccines; Children; Models; Neisseria meningitidis; Human papillomavirus ER - TY - JOUR T1 - Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium AN - 20889253; 7938181 AB - Sensitive biomarkers are needed to detect kidney injury at the earliest stages. The objective of this study was to determine whether the appearance of kidney injury molecule-1 (Kim-1) protein ectodomain in urine and kidney injury molecule-1/hepatitis A viral cellular receptor-1 (Kim-1/Havcr1) gene expression in kidney tissue may be more predictive of renal injury after exposure to nephrotoxicants when compared to traditionally used biomarkers. Male Sprague-Dawley rats were injected with a range of doses of gentamicin, mercury (Hg; HgCl sub(2)), or chromium (Cr; K sub(2)Cr sub(2)O sub(7)). The results showed that increases in urinary Kim-1 and kidney Kim-1/Havcr1 gene expression paralleled the degree of severity of renal histopathology and were detected at lower doses of nephrotoxicants when compared to blood urea nitrogen (BUN), serum creatinine, and urinary N-acetyl- beta -D-glucosaminidase (NAG). In a time course study, urinary Kim-1 was elevated within 24 h after exposure to gentamicin (100 mg/kg), Hg (0.25 mg/kg), or Cr (5 mg/kg) and remained elevated through 72 h. NAG responses were nephrotoxicant dependent with elevations occurring early (gentamicin), late (Cr), or no change (Hg). At 72 h, after treatment with any of the three nephrotoxicants, there was increased Kim-1 immunoreactivity and necrosis involving similar to 50% of the proximal tubules; however, only urinary Kim-1 was significantly increased, while BUN, serum creatinine, and NAG were not different from controls. In rats treated with the hepatotoxicant galactosamine (1.1 mg/kg), serum alanine aminotransferase was increased, but no increase in urinary Kim-1 was observed. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs. JF - Toxicological Sciences AU - Zhou, Yuzhao AU - Vaidya, Vishal S AU - Brown, Ronald P AU - Zhang, Jun AU - Rosenzweig, Barry A AU - Thompson, Karol L AU - Miller, Terry J AU - Bonventre, Joseph V AU - Goering, Peter L AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 159 EP - 170 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 1 SN - 1096-6080, 1096-6080 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Chromium KW - Injuries KW - Urea KW - Alanine transaminase KW - biomarkers KW - Gene expression KW - Gentamicin KW - Blood KW - Necrosis KW - Creatinine KW - Proximal tubules KW - Urine KW - Immunoreactivity KW - Kidney KW - Mercury KW - Hepatitis A KW - Drugs KW - Nitrogen KW - V 22410:Animal Diseases KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20889253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Comparison+of+Kidney+Injury+Molecule-1+and+Other+Nephrotoxicity+Biomarkers+in+Urine+and+Kidney+Following+Acute+Exposure+to+Gentamicin%2C+Mercury%2C+and+Chromium&rft.au=Zhou%2C+Yuzhao%3BVaidya%2C+Vishal+S%3BBrown%2C+Ronald+P%3BZhang%2C+Jun%3BRosenzweig%2C+Barry+A%3BThompson%2C+Karol+L%3BMiller%2C+Terry+J%3BBonventre%2C+Joseph+V%3BGoering%2C+Peter+L&rft.aulast=Zhou&rft.aufirst=Yuzhao&rft.date=2008-01-01&rft.volume=101&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Injuries; Chromium; Urea; Alanine transaminase; biomarkers; Gentamicin; Gene expression; Blood; Necrosis; Creatinine; Proximal tubules; Urine; Immunoreactivity; Kidney; Hepatitis A; Mercury; Drugs; Nitrogen ER - TY - JOUR T1 - Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress AN - 20876465; 8378292 AB - Exposure to cadmium (Cd) elicits a range of adverse responses including oxidative damage and cancer. The molecular targets of Cd remain largely unidentified. Here, we analyzed the function and signal transduction of transcription factor Nrf2 in protection against Cd-induced oxidative stress. Wild-type (Nrf2 super(+/+)) mouse embryonic fibroblasts (MEF) produced reactive oxygen species (ROS) at a low level, whereas treatment with Cd significantly increased the ROS production. On the other hand, Nrf2 knockout (Nrf2 super(-/-)) MEF cells exhibited an elevated level of ROS under a basal condition, and Cd dramatically increased the ROS production at concentrations as low as 2 mu M, resulting in increased sensitivity to Cd-induced cell death. Cd induced the basal and inducible expression of cytoprotective enzymes NQO1 and HO1 in WT MEF cells, but induction was lost in Nrf2 super(-/-) MEF cells. Induction of the genes required antioxidant response elements (ARE) as Cd drove ARE-dependent reporter expression and Cd-activated Nrf2 bound to endogenous AREs in mouse hepa1c1c7 cells. Activation of Nrf2 by Cd involved stabilization of the Nrf2 protein, increased formation of Nrf2/Keap1 complex in the cytoplasm, translocation of the complex into the nucleus, and subsequently disruption of the complex. Lastly, Nrf2 was found ubiquitinated in the cytoplasm but deubiquitinated in the nucleus. The study provided a mechanistic transcriptional model in which Cd activates Nrf2 through a metal-activated signaling pathway involving a dynamic interplay between ubiquitination/deubiquitination and complex formation/dissociation of Nrf2 and Keap1. JF - Chemical Research in Toxicology AU - He, Xiaoqing AU - Chen, Michael G AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1375 EP - 1383 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 21 IS - 7 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Protein transport KW - Antioxidants KW - Regulatory sequences KW - Animal models KW - NRF2 protein KW - Enzymes KW - Cancer KW - ubiquitination KW - Nuclear transport KW - Cell death KW - Reactive oxygen species KW - Oxidative stress KW - Transcription factors KW - Cytoplasm KW - Embryo fibroblasts KW - Cadmium KW - NAD(P)H dehydrogenase (quinone) KW - Nuclei KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20876465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Activation+of+Nrf2+in+Defense+against+Cadmium-Induced+Oxidative+Stress&rft.au=He%2C+Xiaoqing%3BChen%2C+Michael+G%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2008-01-01&rft.volume=21&rft.issue=7&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800019a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Antioxidants; Regulatory sequences; Animal models; Enzymes; NRF2 protein; Cancer; Nuclear transport; ubiquitination; Cell death; Reactive oxygen species; Oxidative stress; Cytoplasm; Transcription factors; Embryo fibroblasts; NAD(P)H dehydrogenase (quinone); Cadmium; Nuclei; Signal transduction DO - http://dx.doi.org/10.1021/tx800019a ER - TY - JOUR T1 - Unsupervised estimation of myocardial displacement from tagged MR sequences using nonrigid registration AN - 20857535; 8368679 AB - We propose a fully automatic cardiac motion estimation technique that uses nonrigid registration between temporally adjacent images to compute the myocardial displacement field from tagged MR sequences using as inputs (sources) both horizontally and vertically tagged images. We present a new multisource nonrigid registration algorithm employing a semilocal deformation model that provides controlled smoothness. The method requires no segmentation. We apply a multiresolution optimization strategy for better speed and robustness. The accuracy of the algorithm is assessed on experimental data (animal model) and healthy volunteer data by calculating the root mean square (RMS) difference in position between the estimated tag trajectories and manual tracings outlined by an expert. For the 20000 tag lines analyzed (45 slices over 20-40 time frames), the RMS difference between the automatic tag trajectories and the manually segmented tag trajectories was 0.51 pixels (0.25 mm) for the animal data and 0.49 pixels (0.49 mm) for the human volunteer data. The RMS difference in the separation between adjacent tag lines (RMS_TS) was also assessed, resulting in an RMS_TS of 0.40 pixels (0.19 mm) in the experimental data and 0.52 pixels (0.56 mm) in the volunteer data. These results confirm the subpixel accuracy achieved using the proposed methodology. Magn Reson Med 2007. JF - Magnetic Resonance in Medicine AU - Ledesma-Carbayo, Maria J AU - Derbyshire, J Andrew AU - Sampath, Smita AU - Santos, Andres AU - Desco, Manuel AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, emcveigh@nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 181 EP - 189 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Segmentation KW - Animal models KW - Algorithms KW - Image processing KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Unsupervised+estimation+of+myocardial+displacement+from+tagged+MR+sequences+using+nonrigid+registration&rft.au=Ledesma-Carbayo%2C+Maria+J%3BDerbyshire%2C+J+Andrew%3BSampath%2C+Smita%3BSantos%2C+Andres%3BDesco%2C+Manuel%3BMcVeigh%2C+Elliot+R&rft.aulast=Ledesma-Carbayo&rft.aufirst=Maria&rft.date=2008-01-01&rft.volume=59&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Algorithms; N.M.R.; Animal models; Segmentation; Image processing; Heart DO - http://dx.doi.org/10.1002/mrm.21444 ER - TY - JOUR T1 - Comparison of Escherichia coli O157:H7 Enrichment in Spiked Produce Samples AN - 20845919; 8027180 AB - Two strains of Escherichia coli O157:H7 were spiked into six varieties of produce at approximately 0.5 CFU g super(-1). Samples were enriched by using the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) method and by using an experimental method incorporating acid shock. Target colonies were detectable on selective agars after 30 of 48 analyses with BAM enrichment and 48 of 48 analyses with acid enrichment. Real-time PCR screening of 24-h enrichment broths revealed the presence of the diagnostic stx sub(1) or stx sub(2) genes after 27 of 48 analyses with BAM enrichment and 42 of 48 analyses with acid enrichment. The efficiency of the enrichment varied with strain and type of produce spiked but overall was better with the experimental enrichment method. Modifications of both the acid enrichment and BAM enrichment methods also were tested. The acid method with a modified incubation temperature consistently yielded high rates of recovery (>10 super(8) CFU ml super(-1)), with no instances in which target cells could not be detected. Modification of the BAM procedure did not reproducibly improve enrichment efficiency. JF - Journal of Food Protection AU - Grant, Michael A AD - U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Bothell, Washington 98021, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 139 EP - 145 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 1 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Temperature effects KW - Agar KW - Colonies KW - Shock KW - Colony-forming cells KW - Escherichia coli KW - Polymerase chain reaction KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Comparison+of+Escherichia+coli+O157%3AH7+Enrichment+in+Spiked+Produce+Samples&rft.au=Grant%2C+Michael+A&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%2971%253C139%3ARNCOCO%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Agar; Colonies; Shock; Colony-forming cells; Polymerase chain reaction; Escherichia coli DO - http://dx.doi.org/10.1043/0362-028X(2008)71%3C139:RNCOCO%3E2.3.CO;2 ER - TY - JOUR T1 - A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells AN - 20819907; 8243987 AB - Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad. A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and computerized image analysis. The method is sensitive, quantitative and reproducible, with a linear range spanning two orders of magnitude. As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%. JF - Journal of Virological Methods AU - Smith, J S AU - Xu, Z AU - Byrnes, A P AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA, JeffreyS.Smith@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 54 EP - 60 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 147 IS - 1 SN - 0166-0934, 0166-0934 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Expression vectors KW - Virions KW - Kupffer cells KW - Gene therapy KW - Hepatocytes KW - Confocal microscopy KW - Adenovirus KW - Image processing KW - W 30905:Medical Applications KW - V 22300:Methods KW - F 06900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20819907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=A+quantitative+assay+for+measuring+clearance+of+adenovirus+vectors+by+Kupffer+cells&rft.au=Smith%2C+J+S%3BXu%2C+Z%3BByrnes%2C+A+P&rft.aulast=Smith&rft.aufirst=J&rft.date=2008-01-01&rft.volume=147&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2007.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virions; Expression vectors; Kupffer cells; Gene therapy; Hepatocytes; Confocal microscopy; Image processing; Adenovirus DO - http://dx.doi.org/10.1016/j.jviromet.2007.08.009 ER - TY - JOUR T1 - The Fda Critical Path Initiative and Its Influence on New Drug Development AN - 20815063; 8190336 AB - Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. An important part of the initiative is the use of public-private partnerships and consortia to accomplish the needed research. This article explicates the reasoning behind the Critical Path Initiative and discusses examples of successful consortia. JF - Annual Review of Medicine AU - Woodcock, Janet AU - Woosley, Raymond AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, Janet.Woodcock@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 12 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 59 SN - 0066-4219, 0066-4219 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Pharmaceuticals KW - Drug development KW - genomics KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20815063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+Fda+Critical+Path+Initiative+and+Its+Influence+on+New+Drug+Development&rft.au=Woodcock%2C+Janet%3BWoosley%2C+Raymond&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2008-01-01&rft.volume=59&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.59.090506.155819 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reviews; Pharmaceuticals; Drug development; genomics; imaging DO - http://dx.doi.org/10.1146/annurev.med.59.090506.155819 ER - TY - JOUR T1 - Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells AN - 20796244; 10885632 AB - Introduction Mesenchymal progenitor cells (MPCs) are multipotent progenitor cells in adult tissues, for example, bone marrow (BM). Current challenges of clinical application of BM-derived MPCs include donor site morbidity and pain as well as low cell yields associated with an age-related decrease in cell number and differentiation potential, underscoring the need to identify alternative sources of MPCs. Recently, MPC sources have diversified; examples include adipose, placenta, umbilicus, trabecular bone, cartilage, and synovial tissue. In the present work, we report the presence of MPCs in human tonsillar tissue. Methods We performed comparative and quantitative analyses of BM-MPCs with a subpopulation of adherent cells isolated from this lymphoid tissue, termed tonsil-derived MPCs (T-MPCs). The expression of surface markers was assessed by fluorescent-activated cell sorting analysis. Differentiation potential of T-MPCs was analyzed histochemically and by reverse transcription-polymerase chain reaction for the expression of lineage-related marker genes. The immunosuppressive properties of MPCs were determined in vitro in mixed lymphocyte reactions. Results Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs. Similar to BM-MPCs, T-MPCs could be induced to undergo adipogenic differentiation and, to a lesser extent, osteogenic and chondrogenic differentiation. T-MPCs did not express class II major histocompatibility (MHC) antigens, and in a similar but less pronounced manner compared with BM-MPCs, T-MPCs were immunosuppressive, inhibiting the proliferation of T cells stimulated by allogeneic T cells or by non-specific mitogenic stimuli via an indoleamine 2,3-dioxygenase-dependent mechanism. Conclusion Human palatine T-MPCs represent a new source of progenitor cells, potentially applicable for cell-based therapies. JF - Arthritis Research & Therapy AU - Janjanin, S AU - Djouad, F AU - Shanti, R M AU - Baksh, D AU - Gollapudi, K AU - Prgomet, D AU - Rackwitz, L AU - Joshi, A S AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 1 VL - 10 IS - 4 SN - 1478-6354, 1478-6354 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Mixed leukocyte reaction KW - Therapeutic applications KW - Differentiation KW - Stem cells KW - Placenta KW - Lymphocytes T KW - CD105 antigen KW - CD45 antigen KW - CD34 antigen KW - Bone (trabecular) KW - CD90 antigen KW - CD29 antigen KW - Cell proliferation KW - Age KW - Cartilage KW - CD44 antigen KW - Bone marrow KW - Major histocompatibility complex KW - Pain KW - CD14 antigen KW - Morbidity KW - Tonsil KW - Mesenchyme KW - Epitopes KW - Cell number KW - Umbilicus KW - Lymphoid tissue KW - Surface markers KW - Adherent cells KW - W 30920:Tissue Engineering KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20796244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Human+palatine+tonsil%3A+a+new+potential+tissue+source+of+multipotent+mesenchymal+progenitor+cells&rft.au=Janjanin%2C+S%3BDjouad%2C+F%3BShanti%2C+R+M%3BBaksh%2C+D%3BGollapudi%2C+K%3BPrgomet%2C+D%3BRackwitz%2C+L%3BJoshi%2C+A+S%3BTuan%2C+R+S&rft.aulast=Janjanin&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=4&rft.spage=R83&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2459 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Tonsil; Major histocompatibility complex; Lymphocytes T; Mesenchyme; Bone (trabecular); CD105 antigen; Bone marrow; CD45 antigen; Mixed leukocyte reaction; Cell proliferation; CD34 antigen; CD90 antigen; Cell number; Epitopes; CD14 antigen; Therapeutic applications; Adherent cells; Placenta; Morbidity; Umbilicus; CD44 antigen; Age; CD29 antigen; Surface markers; Lymphoid tissue; Pain; Cartilage DO - http://dx.doi.org/10.1186/ar2459 ER - TY - JOUR T1 - The Role of Standards and Guidance in Advancing Device Technology AN - 20791189; 8334218 AB - Advancing medical device technology from the design to delivery to patients takes many steps, typically including design or modification of an existing device, bench or laboratory testing, risk analysis, clinical testing (if appropriate), review of the device by regulatory agencies, and post-market surveillance by both the regulatory agency and the manufacturer. The development of technical guidance documents or international standards has made this process more efficient in the United States, though these processes are both underutilized and underappreciated. The history of the use of these approaches will be described, as well as recent progress and how the future of guidance and standards may evolve. JF - Journal of Biolaw & Business AU - Kessler, L AU - Herman, CL AD - Office of Science and Engineering Laboratories of the Center for Devices and Radiological Health (CDRH), Food and Drug Administration Y1 - 2008 PY - 2008 DA - 2008 SP - 10 EP - 14 VL - 11 IS - 1 SN - 1095-5127, 1095-5127 KW - Risk Abstracts KW - Historical account KW - Laboratory testing KW - medical equipment KW - USA KW - Reviews KW - International standardization KW - Technology KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20791189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biolaw+%26+Business&rft.atitle=The+Role+of+Standards+and+Guidance+in+Advancing+Device+Technology&rft.au=Kessler%2C+L%3BHerman%2C+CL&rft.aulast=Kessler&rft.aufirst=L&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biolaw+%26+Business&rft.issn=10955127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Technology; Reviews; Laboratory testing; Historical account; medical equipment; International standardization ER - TY - JOUR T1 - The Rules Are Old, But the Game Is Changing: Life Sciences and the Foreign Corrupt Practices Act AN - 20785977; 8334220 AB - The Foreign Corrupt Practices Act turned 30 this year. Historically life sciences companies have not focused extensively on compliance with this decades-old statute, as enforcement actions were relatively few and tended to target companies in other industries. But as the biotechnology industry and the FCPA enter their fourth decade the game is changing. Regulators are ramping up overall enforcement and increasing their scrutiny of life sciences companies. This increased enforcement coincides with industry trends towards increased cross-border relationships and access to emerging markets. This article discusses this environment of heightened risk and provides insights for companies looking to mitigate risk and play by the changing rules of the game. JF - Journal of Biolaw & Business AU - Acosta, T AD - U.S. Department of Health and Human Services (OIG) in Washington, DC, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 19 EP - 21 VL - 11 IS - 1 SN - 1095-5127, 1095-5127 KW - Foreign Corrupt Practices Act KW - Risk Abstracts KW - Historical account KW - emerging markets KW - Compliance KW - Biotechnology KW - Legislation KW - R2 23090:Policy and planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20785977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biolaw+%26+Business&rft.atitle=The+Rules+Are+Old%2C+But+the+Game+Is+Changing%3A+Life+Sciences+and+the+Foreign+Corrupt+Practices+Act&rft.au=Acosta%2C+T&rft.aulast=Acosta&rft.aufirst=T&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biolaw+%26+Business&rft.issn=10955127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Compliance; Legislation; Historical account; emerging markets; Biotechnology ER - TY - JOUR T1 - Survey Results of Benzene in Soft Drinks and Other Beverages by Headspace Gas Chromatography/Mass Spectrometry AN - 20762095; 8024443 AB - Benzene, a carcinogen that can cause cancer in humans, may form at nanogram per gram levels in some beverages containing both benzoate salts and ascorbic or erythorbic acids. Through a series of reactions, a hydroxyl radical forms that can decarboxylate benzoate to form benzene. Elevated temperatures and light stimulate these reactions, while sugar and ethylenediaminetetraacetic acid (EDTA) can inhibit them. A headspace gas chromatography/mass spectrometry method for the determination of benzene in beverages was developed and validated. The method was used to conduct a survey of 199 soft drinks and other beverages. The vast majority of beverages sampled contained either no detectable benzene or levels below the U.S. Environmental Protection Agency's drinking water limit of 5 ng/g. Beverages found to contain 5 ng/g benzene or more were reformulated by the manufacturers. The amount of benzene found in the reformulated beverages ranged from none detected to 1.1 ng/g. JF - Journal of Agricultural and Food Chemistry AU - Nyman, Patricia J AU - Diachenko, Gregory W AU - Perfetti, Gracia A AU - McNeal, Timothy P AU - Hiatt, Michael H AU - Morehouse, Kim M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-706, 5100 Paint Branch Parkway, College Park, Maryland 20740 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 571 EP - 576 PB - American Chemical Society, [mailto:service@acs.org] VL - 56 IS - 2 SN - 0021-8561, 0021-8561 KW - Toxicology Abstracts KW - Benzene KW - beverages KW - headspace KW - gas chromatography/mass spectrometry. KW - Temperature effects KW - Sugar KW - Benzoic acid KW - Beverages KW - Free radicals KW - Carcinogens KW - Cancer KW - Mass spectroscopy KW - Light effects KW - Salts KW - Gas chromatography KW - Acids KW - Headspace KW - Drinking water KW - Edetic acid KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Survey+Results+of+Benzene+in+Soft+Drinks+and+Other+Beverages+by+Headspace+Gas+Chromatography%2FMass+Spectrometry&rft.au=Nyman%2C+Patricia+J%3BDiachenko%2C+Gregory+W%3BPerfetti%2C+Gracia+A%3BMcNeal%2C+Timothy+P%3BHiatt%2C+Michael+H%3BMorehouse%2C+Kim+M&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2008-01-01&rft.volume=56&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf072479l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Sugar; Beverages; Benzoic acid; Free radicals; Carcinogens; Benzene; Mass spectroscopy; Cancer; Light effects; Salts; Gas chromatography; Acids; Headspace; Drinking water; Edetic acid DO - http://dx.doi.org/10.1021/jf072479l ER - TY - JOUR T1 - Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study AN - 20735944; 8035947 AB - Meats cooked at high temperatures, such as pan-frying or grilling, are a source of carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively examined the association between meat types, meat cooking methods, meat doneness, and meat mutagens and the risk for prostate cancer in the Agricultural Health Study. We estimated relative risks and 95% confidence intervals (95% CI) for prostate cancer using Cox proportional hazards regression using age as the underlying time metric and adjusting for state of residence, race, smoking status, and family history of prostate cancer. During 197,017 person-years of follow-up, we observed 668 incident prostate cancer cases (613 of these were diagnosed after the first year of follow-up and 140 were advanced cases) among 23,080 men with complete dietary data. We found no association between meat type or specific cooking method and prostate cancer risk. However, intake of well or very well done total meat was associated with a 1.26-fold increased risk of incident prostate cancer (95% CI, 1.02-1.54) and a 1.97-fold increased risk of advanced disease (95% CI, 1.26-3.08) when the highest tertile was compared with the lowest. Risks for the two heterocyclic amines 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline and 2-amino-3,8-dimethylimidazo-[4,5-b]quinoxaline were of borderline significance for incident disease [1.24 (95% CI, 0.96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort. (Cancer Epidemiol Biomarkers Prev 2008; 17(1):80-7) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Koutros, Stella AU - Cross, Amanda J AU - Sandler, Dale P AU - Hoppin, Jane A AU - Ma, Xiaomei AU - Zheng, Tongzhang AU - Alavanja, Michael CR AU - Sinha, Rashmi AD - Occupational and Environmental Epidemiology Branch and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 80 EP - 87 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 1 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Mutagens KW - Age KW - Smoking KW - Genetics KW - Carcinogenicity KW - prevention KW - cooking KW - prostate cancer KW - Diets KW - Bioindicators KW - Amines KW - Cancer KW - polycyclic aromatic hydrocarbons KW - high temperature KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20735944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Meat+and+Meat+Mutagens+and+Risk+of+Prostate+Cancer+in+the+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BCross%2C+Amanda+J%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A%3BMa%2C+Xiaomei%3BZheng%2C+Tongzhang%3BAlavanja%2C+Michael+CR%3BSinha%2C+Rashmi&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2008-01-01&rft.volume=17&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prostate cancer; Cancer; Bioindicators; cooking; Mutagens; Amines; Genetics; Carcinogenicity; Diets; polycyclic aromatic hydrocarbons; prevention; high temperature; Smoking; Age ER - TY - JOUR T1 - A regulatory perspective on the development of gene therapy for Parkinson's disease AN - 20734385; 8750614 JF - Experimental Neurology AU - Havert, Michael B AD - Food and Drug Administration, Center for Biologics Evaluation and Review, Office of Cellular, Tissue, and Gene Therapies, Division of Cellular and Gene Therapies, 1401 Rockville Pike, HFM-720, Rockville, MD 20852, USA, mike.havert@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 48 EP - 50 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 209 IS - 1 SN - 0014-4886, 0014-4886 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Movement disorders KW - Gene therapy KW - Parkinson's disease KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Neurology&rft.atitle=A+regulatory+perspective+on+the+development+of+gene+therapy+for+Parkinson%27s+disease&rft.au=Havert%2C+Michael+B&rft.aulast=Havert&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=209&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Experimental+Neurology&rft.issn=00144886&rft_id=info:doi/10.1016%2Fj.expneurol.2007.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Movement disorders; Gene therapy; Parkinson's disease DO - http://dx.doi.org/10.1016/j.expneurol.2007.08.010 ER - TY - JOUR T1 - Structure and Function of the Virulence-Associated High-Temperature Requirement A of Mycobacterium tuberculosis AN - 20712785; 8236740 AB - The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis (Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 Aa resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb. JF - Biochemistry (Washington) AU - Russell, David H AU - Jacobs, William R AU - MohamedMohaideen, Nilofar N AU - Williams, Brad J AU - Sacchettini, James C AU - Palaninathan, Satheesh K AU - Morin, Paul M AU - Braunstein, Miriam AU - Tichy, Shane E AU - Locker, Joseph AD - Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, Department of Chemistry, Texas A&M University, College Station, Texas 77842, Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, U.S. Food and Drug Administration, Microbiological Sciences Branch, Jamaica, New York 11433, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 6092 EP - 6102 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 47 IS - 23 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Serine proteinase KW - Structure-function relationships KW - Escherichia coli KW - Animal models KW - Biochemical analysis KW - Stress KW - Tuberculosis KW - Chaperones KW - Serine KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20712785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structure+and+Function+of+the+Virulence-Associated+High-Temperature+Requirement+A+of+Mycobacterium+tuberculosis&rft.au=Russell%2C+David+H%3BJacobs%2C+William+R%3BMohamedMohaideen%2C+Nilofar+N%3BWilliams%2C+Brad+J%3BSacchettini%2C+James+C%3BPalaninathan%2C+Satheesh+K%3BMorin%2C+Paul+M%3BBraunstein%2C+Miriam%3BTichy%2C+Shane+E%3BLocker%2C+Joseph&rft.aulast=Russell&rft.aufirst=David&rft.date=2008-01-01&rft.volume=47&rft.issue=23&rft.spage=6092&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701929m LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Virulence; Serine proteinase; Structure-function relationships; Animal models; Stress; Biochemical analysis; Chaperones; Tuberculosis; Serine; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1021/bi701929m ER - TY - JOUR T1 - Incidence and Completeness of Notification of Legionnaires' Disease in the Netherlands: Covariate Capture-Recapture Analysis Acknowledging Regional Differences AN - 20691150; 8213086 AB - To estimate incidence and completeness of notification of Legionnaires' disease (LD) in The Netherlands in 2000 and 2001, we performed a capture- recapture analysis using three registers: Notifications, Laboratory results and Hospital admissions. After record-linkage, 373 of the 780 LD patients identified were notified. Ascertained under-notification was 52 super(.)2%. Because of expected and observed regional differences in the incidence rate of LD, alternatively to conventional log-linear capture-recapture models, a covariate (region) capture-recapture model, not previously used for estimating infectious disease incidence, was specified and estimated 886 LD patients (95% confidence interval 827-1022). Estimated under-notification was 57 super(.)9%. Notified, ascertained and estimated average annual incidence rates of LD were 1 super(.)15, 2 super(.)42 and 2 super(.)77/100 000 inhabitants respectively, with the highest incidence in the southern region of The Netherlands. Covariate capture-recapture analysis acknowledging regional differences of LD incidence appears to reduce bias in the estimated national incidence rate. JF - Epidemiology and Infection AU - Van Hest, NAH AU - Hoebe, CJPA AU - Boer, JWDen AU - Vermunt, J K AU - Ijzerman, EPF AU - Boersma, W G AU - Richardus, J H AD - Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2008 PY - 2008 DA - 2008 SP - 540 EP - 550 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 136 IS - 4 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20691150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Incidence+and+Completeness+of+Notification+of+Legionnaires%27+Disease+in+the+Netherlands%3A+Covariate+Capture-Recapture+Analysis+Acknowledging+Regional+Differences&rft.au=Van+Hest%2C+NAH%3BHoebe%2C+CJPA%3BBoer%2C+JWDen%3BVermunt%2C+J+K%3BIjzerman%2C+EPF%3BBoersma%2C+W+G%3BRichardus%2C+J+H&rft.aulast=Van+Hest&rft.aufirst=NAH&rft.date=2008-01-01&rft.volume=136&rft.issue=4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268807008977 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1017/S0950268807008977 ER - TY - JOUR T1 - Potential Use of DNA Barcodes in Regulatory Science: Applications of the Regulatory Fish Encyclopedia AN - 20686448; 8027193 AB - The use of a DNA-based identification system (DNA barcoding) founded on the mitochondrial gene cytochrome c oxidase subunit I (COI) was investigated for updating the U.S. Food and Drug Administration Regulatory Fish Encyclopedia (RFE; http://www.cfsan.fda.gov/ similar to frf/rfe0.html). The RFE is a compilation of data used to identify fish species. It was compiled to help regulators identify species substitution that could result in potential adverse health consequences or could be a source of economic fraud. For each of many aquatic species commonly sold in the United States, the RFE includes high-resolution photographs of whole fish and their marketed product forms and species-specific biochemical patterns for authenticated fish species. These patterns currently include data from isoelectric focusing studies. In this article, we describe the generation of DNA barcodes for 172 individual authenticated fish representing 72 species from 27 families contained in the RFE. These barcode sequences can be used as an additional identification resource. In a blind study, 60 unknown fish muscle samples were barcoded, and the results were compared with the RFE barcode reference library. All 60 samples were correctly identified to species based on the barcoding data. Our study indicates that DNA barcoding can be a powerful tool for species identification and has broad potential applications. JF - Journal of Food Protection AU - Yancy, Haile F AU - Zemlak, Tyler S AU - Mason, Jacquline A AU - Washington, Jewell D AU - Tenge, Bradley J AU - Nguyen, Ngoc-Lan T AU - Barnett, James D AU - Savary, Warren E AU - Hill, Walter E AU - Moore, Michelle M AU - Fry, Frederick S AU - Randolph, Spring C AU - Rogers, Patricia L AU - Hebert, Paul DN AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 210 EP - 217 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com] VL - 71 IS - 1 SN - 0362-028X, 0362-028X KW - ASFA Marine Biotechnology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Biochemistry Abstracts 2: Nucleic Acids KW - Biological surveys KW - Institutional resources KW - Nucleotide sequence KW - Muscles KW - Mitochondria KW - Cytochrome-c oxidase KW - Isoelectric focusing KW - Fishery biology KW - Pisces KW - Population genetics KW - USA KW - Encyclopaedias KW - Economics KW - Photographs KW - DNA KW - Nature conservation KW - Q5 08523:Conservation, wildlife management and recreation KW - Q4 27740:Products KW - Q1 08109:Books, atlases and charts KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20686448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Potential+Use+of+DNA+Barcodes+in+Regulatory+Science%3A+Applications+of+the+Regulatory+Fish+Encyclopedia&rft.au=Yancy%2C+Haile+F%3BZemlak%2C+Tyler+S%3BMason%2C+Jacquline+A%3BWashington%2C+Jewell+D%3BTenge%2C+Bradley+J%3BNguyen%2C+Ngoc-Lan+T%3BBarnett%2C+James+D%3BSavary%2C+Warren+E%3BHill%2C+Walter+E%3BMoore%2C+Michelle+M%3BFry%2C+Frederick+S%3BRandolph%2C+Spring+C%3BRogers%2C+Patricia+L%3BHebert%2C+Paul+DN&rft.aulast=Yancy&rft.aufirst=Haile&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%2971%253C210%3ARNPUOD%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biological surveys; Population genetics; Institutional resources; Encyclopaedias; Nucleotide sequence; Photographs; Nature conservation; DNA; Fishery biology; Economics; Muscles; Mitochondria; Cytochrome-c oxidase; Isoelectric focusing; Pisces; USA DO - http://dx.doi.org/10.1043/0362-028X(2008)71%3C210:RNPUOD%3E2.3.CO;2 ER - TY - JOUR T1 - Equivalency of a personal dust monitor to the current United States coal mine respirable dust sampler AN - 20630633; 8045234 AB - The United States National Institute for Occupational Safety and Health, through an informal partnership with industry, labor, and the United States Mine Safety and Health Administration, has developed and tested a new instrument known as the Personal Dust Monitor (PDM). The new dust monitor is an integral part of the cap lamp that coal miners normally carry to work and provides continuous information about the concentration of respirable coal mine dust within the breathing zone of that individual. Previous laboratory testing demonstrated that there is a 95% confidence that greater than 95% of individual PDM measurements fall within plus or minus 25% of reference measurements. The work presented in this paper focuses on the relationship between the PDM and respirable dust concentrations currently measured by a coal mine dust personal sampler unit utilizing a 10 mm Dorr-Oliver nylon cyclone. The United Kingdom Mining Research Establishment instrument, used as the basis for coal mine respirable dust standards, had been designed specifically to match the United Kingdom British Medical Research Council (BMRC) criterion. The personal sampler is used with a 1.38 multiplier to convert readings to the BMRC criterion. A stratified random sampling design incorporating a proportionate allocation strategy was used to select a sample of mechanized mining units representative of all US underground coal mines. A sample of 180 mechanized mining units was chosen, representing approximately 20% of the mechanized mining units in production at the time the sample was selected. A total of 129 valid PDM/personal sampler dust sample sets were obtained. A weighted linear regression analysis of this data base shows that, in comparison with the personal sampler, the PDM requires a mass equivalency conversion multiplier of 1.05 [95% C.I. = (1.03, 1.08)] when the small intercept term is removed from the analysis. Removal of the intercept term results in a personal sampler-equivalent concentration increase of 2.9% at a PDM measurement of 2.0 mg m super(3). JF - Journal of Environmental Monitoring AU - Page, S J AU - Volkwein, J C AU - Vinson, R P AU - Joy, G J AU - Mischler, SE AU - Tuchman, D P AU - McWilliams, L J AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 96 EP - 101 VL - 10 IS - 1 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Safety regulations KW - Laboratory testing KW - Coal KW - medical research KW - Dust KW - USA KW - councils KW - Air sampling KW - Mining KW - Occupational exposure KW - Data bases KW - Monitoring instruments KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20630633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Equivalency+of+a+personal+dust+monitor+to+the+current+United+States+coal+mine+respirable+dust+sampler&rft.au=Page%2C+S+J%3BVolkwein%2C+J+C%3BVinson%2C+R+P%3BJoy%2C+G+J%3BMischler%2C+SE%3BTuchman%2C+D+P%3BMcWilliams%2C+L+J&rft.aulast=Page&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb714381h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Safety regulations; Laboratory testing; councils; Air sampling; medical research; Mining; Coal; Data bases; Occupational exposure; Dust; Monitoring instruments; USA DO - http://dx.doi.org/10.1039/b714381h ER - TY - JOUR T1 - Air pollution and risk of urinary bladder cancer in a case-control study in Spain AN - 20508662; 7936958 AB - OBJECTIVES: Air pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk. METHODS: Information from a case-control study in Spain that included 1219 incident cases and 1271 hospital controls was used. Information on residential history including several indicators of exposure to air pollution and other potential risk factors was collected in a face-to-face computerised personal interview. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, smoking, occupation, water contaminants and diet. RESULTS: Living more than 40 years in a city with a population of more than 100 000 was associated with an increased risk for bladder cancer overall (OR 1.30, 95% CI 1.04 to 1.63). Emissions of polycyclic aromatic hydrocarbons and diesel from industries near the residence, as evaluated by experts, were associated with an increased risk (OR 1.29, 95% CI 0.85 to 1.98), while lower or no excess risks were observed for other pollution-related variables. Odds ratios among never smokers tended to be higher than among smokers. CONCLUSIONS: The small to moderate positive associations found for several indices of air pollution and bladder cancer, while suggestive of excess risk, require further evaluation in other settings. JF - Occupational and Environmental Medicine AU - Castano-Vinyals, Gemma AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Garcia-Closas, Reina AU - Serra, Consol AU - Carrato, Alfredo AU - Rothman, Nathaniel AU - Vermeulen, Roel AU - Silverman, Debra AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Universidad de Oviedo, Oviedo, Spain. Unidad de Investigacion, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Consorci Hospitalari Parc Tauli, Sabadell, Spain. Hospital General de Elche, Elche, Spain. Institute of Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands. Department of Social Medicine, Medical School, University of Crete, Herakleion, Crete, Greece. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 56 EP - 60 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 1 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts; Pollution Abstracts KW - Historical account KW - Age KW - Spain KW - Pollution effects KW - urinary bladder KW - Smoking KW - Risk factors KW - Emissions KW - Urban areas KW - Lung cancer KW - Diets KW - Polycyclic aromatic hydrocarbons KW - Urinary bladder KW - Cancer KW - Air pollution KW - Gender KW - polycyclic aromatic hydrocarbons KW - Diesel KW - Contaminants KW - emergency medical services KW - Hospitals KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20508662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Air+pollution+and+risk+of+urinary+bladder+cancer+in+a+case-control+study+in+Spain&rft.au=Castano-Vinyals%2C+Gemma%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Castano-Vinyals&rft.aufirst=Gemma&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Air pollution; Smoking; Polycyclic aromatic hydrocarbons; Urinary bladder; Risk factors; Diesel; Contaminants; Lung cancer; Hospitals; Historical account; Age; Pollution effects; Cancer; urinary bladder; Gender; Emissions; polycyclic aromatic hydrocarbons; emergency medical services; Urban areas; Spain ER - TY - JOUR T1 - Dialysis Surveillance Report: National Healthcare Safety Network (NHSN)-Data Summary for 2006 AN - 20473995; 9154874 AB - AbstractThirty-two outpatient hemodialysis providers in the United States voluntarily reported 3699 adverse events to the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) during 2006. These providers were previously enrolled in the Dialysis Surveillance Network. The pooled mean rates of hospitalization among patients with arteriovenous fistulas, grafts, permanent and temporary central venous catheters were 7.7, 9.2, 15.7, and 34.7 per 100 patient-months, respectively. For bloodstream infection the pooled mean rates were 0.5, 0.9, 4.2, and 27.1 per 100 patient-months in these groups. Among the 599 isolates reported, 461 (77%) represented access-associated blood stream infections in patients with central lines, and 138 (23%) were in patients with fistulas or grafts. The microorganisms most frequently identified were common skin contaminants (e.g., coagulase-negative staphylococci). In 2007, enrollment in NHSN opened to all providers of outpatient hemodialysis. Specific information is available at http://www.cdc.gov/ncidod/dhqp/nhsn_FAQenrollment.html. JF - Seminars in Dialysis AU - Klevens, RMonina AU - Edwards, Jonathan R AU - Andrus, Mary L AU - Peterson, Kelly D AU - Dudeck, Margaret A AU - Horan, Teresa C AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, rmk2@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 24 EP - 28 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 21 IS - 1 SN - 0894-0959, 0894-0959 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Blood KW - Skin KW - Microorganisms KW - Disease control KW - Catheters KW - Infection KW - Contaminants KW - Hemodialysis KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20473995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Dialysis&rft.atitle=Dialysis+Surveillance+Report%3A+National+Healthcare+Safety+Network+%28NHSN%29-Data+Summary+for+2006&rft.au=Klevens%2C+RMonina%3BEdwards%2C+Jonathan+R%3BAndrus%2C+Mary+L%3BPeterson%2C+Kelly+D%3BDudeck%2C+Margaret+A%3BHoran%2C+Teresa+C&rft.aulast=Klevens&rft.aufirst=RMonina&rft.date=2008-01-01&rft.volume=21&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Dialysis&rft.issn=08940959&rft_id=info:doi/10.1111%2Fj.1525-139X.2007.00379.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood; Skin; Catheters; Disease control; Microorganisms; Contaminants; Infection; Hemodialysis DO - http://dx.doi.org/10.1111/j.1525-139X.2007.00379.x ER - TY - JOUR T1 - Low frequency magnetic emissions and resulting induced voltages in a pacemaker by iPod portable music players AN - 20358522; 9030659 AB - Background Recently, malfunctioning of a cardiac pacemaker electromagnetic, caused by electromagnetic interference (EMI) by fields emitted by personal portable music players was highly publicized around the world. A clinical study of one patient was performed and two types of interference were observed when the clinicians placed a pacemaker programming head and an iPod were placed adjacent to the patient's implanted pacemaker. The authors concluded that "Warning labels may be needed to avoid close contact between pacemakers and iPods". We performed an in-vitro study to evaluate these claims of EMI and present our findings of no-effects" in this paper. Methods We performed in-vitro evaluations of the low frequency magnetic field emissions from various models of the Apple Inc. iPod music player. We measured magnetic field emissions with a 3-coil sensor (diameter of 3.5 cm) placed within 1 cm of the surface of the player. Highly localized fields were observed (only existing in a one square cm area). We also measured the voltages induced inside an 'instrumented-can' pacemaker with two standard unipolar leads. Each iPod was placed in the air, 2.7 cm above the pacemaker case. The pacemaker case and leads were placed in a saline filled torso simulator per pacemaker electromagnetic compatibility standard ANSI/AAMI PC69:2000. Voltages inside the can were measured. Results Emissions were strongest ( approximately 0.2 mu T pp) near a few localized points on the cases of the two iPods with hard drives. Emissions consisted of 100 kHz sinusoidal signal with lower frequency (20 msec wide) pulsed amplitude modulation. Voltages induced in the iPods were below the noise level of our instruments (0.5 mV pp in the 0 - 1 kHz band or 2 mV pp in the 0 - 5 MHz bandwidth. Conclusion Our measurements of the magnitude and the spatial distribution of low frequency magnetic flux density emissions by 4 different models of iPod portable music players. Levels of less than 0.2 mu T exist very close (1 cm) from the case. The measured voltages induced inside an 'instrumented-can' pacemaker were below the noise level of our instruments. Based on the observations of our in-vitro study we conclude that no interference effects can occur in pacemakers exposed to the iPod devices we tested. JF - BioMedical Engineering OnLine AU - Bassen, Howard AD - U.S. Food and Drug Administration, Silver Spring, MD 20993, USA, howard.bassen@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 7 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Magnetic fields KW - Head KW - Spatial distribution KW - Malus KW - Pacemakers KW - Models KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMedical+Engineering+OnLine&rft.atitle=Low+frequency+magnetic+emissions+and+resulting+induced+voltages+in+a+pacemaker+by+iPod+portable+music+players&rft.au=Bassen%2C+Howard&rft.aulast=Bassen&rft.aufirst=Howard&rft.date=2008-01-01&rft.volume=7&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=BioMedical+Engineering+OnLine&rft.issn=1475-925X&rft_id=info:doi/10.1186%2F1475-925X-7-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Magnetic fields; Spatial distribution; Head; Pacemakers; Models; Malus DO - http://dx.doi.org/10.1186/1475-925X-7-7 ER - TY - JOUR T1 - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies AN - 20352121; 9023569 AB - Background Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) are not reproducible in similar experiments. Meanwhile, new statistical methods for identifying DEGs continue to appear in the scientific literature. The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists. Results Using the data sets generated by the MicroArray Quality Control (MAQC) project, we investigated the impact on the reproducibility of DEG lists of a few widely used gene selection procedures. We present comprehensive results from inter-site comparisons using the same microarray platform, cross-platform comparisons using multiple microarray platforms, and comparisons between microarray results and those from TaqMan - the widely regarded "standard" gene expression platform. Our results demonstrate that (1) previously reported discordance between DEG lists could simply result from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion with a non-stringent P-value cutoff filtering, the DEG lists become much more reproducible, especially when fewer genes are selected as differentially expressed, as is the case in most microarray studies; and (3) the instability of short DEG lists solely based on P-value ranking is an expected mathematical consequence of the high variability of the t-values; the more stringent the P-value threshold, the less reproducible the DEG list is. These observations are also consistent with results from extensive simulation calculations. Conclusion We recommend the use of FC-ranking plus a non-stringent P cutoff as a straightforward and baseline practice in order to generate more reproducible DEG lists. Specifically, the P-value cutoff should not be stringent (too small) and FC should be as large as possible. Our results provide practical guidance to choose the appropriate FC and P-value cutoffs when selecting a given number of DEGs. The FC criterion enhances reproducibility, whereas the P criterion balances sensitivity and specificity. JF - BMC Bioinformatics AU - Shi, Leming AU - Jones, Wendell D AU - Jensen, Roderick V AU - Harris, Stephen C AU - Perkins, Roger G AU - Goodsaid, Federico M AU - Guo, Lei AU - Croner, Lisa J AU - Boysen, Cecilie AU - Fang, Hong AU - Qian, Feng AU - Amur, Shashi AU - Bao, Wenjun AU - Barbacioru, Catalin C AU - Bertholet, Vincent AU - Cao, Xiaoxi Megan AU - Chu, Tzu-Ming AU - Collins, Patrick J AU - Fan, Xiao-hui AU - Frueh, Felix W AU - Fuscoe, James C AU - Guo, Xu AU - Han, Jing AU - Herman, Damir AU - Hong, Huixiao AU - Kawasaki, Ernest S AU - Li, Quan-Zhen AU - Luo, Yuling AU - Ma, Yunqing AU - Mei, Nan AU - Peterson, Ron L AU - Puri, Raj K AU - Shippy, Richard AU - Su, Zhenqiang AU - Sun, Yongming Andrew AU - Sun, Hongmei AU - Thorn, Brett AU - Turpaz, Yaron AU - Wang, Charles AU - Wang, Sue Jane AU - Warrington, Janet A AU - Willey, James C AU - Wu, Jie AU - Xie, Qian AU - Zhang, Liang AU - Zhang, Lu AU - Zhong, Sheng AU - Wolfinger, Russell D AU - Tong, Weida AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, leming.shi@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S10 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Statistics KW - Data processing KW - Quality control KW - Discordance KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=The+balance+of+reproducibility%2C+sensitivity%2C+and+specificity+of+lists+of+differentially+expressed+genes+in+microarray+studies&rft.au=Shi%2C+Leming%3BJones%2C+Wendell+D%3BJensen%2C+Roderick+V%3BHarris%2C+Stephen+C%3BPerkins%2C+Roger+G%3BGoodsaid%2C+Federico+M%3BGuo%2C+Lei%3BCroner%2C+Lisa+J%3BBoysen%2C+Cecilie%3BFang%2C+Hong%3BQian%2C+Feng%3BAmur%2C+Shashi%3BBao%2C+Wenjun%3BBarbacioru%2C+Catalin+C%3BBertholet%2C+Vincent%3BCao%2C+Xiaoxi+Megan%3BChu%2C+Tzu-Ming%3BCollins%2C+Patrick+J%3BFan%2C+Xiao-hui%3BFrueh%2C+Felix+W%3BFuscoe%2C+James+C%3BGuo%2C+Xu%3BHan%2C+Jing%3BHerman%2C+Damir%3BHong%2C+Huixiao%3BKawasaki%2C+Ernest+S%3BLi%2C+Quan-Zhen%3BLuo%2C+Yuling%3BMa%2C+Yunqing%3BMei%2C+Nan%3BPeterson%2C+Ron+L%3BPuri%2C+Raj+K%3BShippy%2C+Richard%3BSu%2C+Zhenqiang%3BSun%2C+Yongming+Andrew%3BSun%2C+Hongmei%3BThorn%2C+Brett%3BTurpaz%2C+Yaron%3BWang%2C+Charles%3BWang%2C+Sue+Jane%3BWarrington%2C+Janet+A%3BWilley%2C+James+C%3BWu%2C+Jie%3BXie%2C+Qian%3BZhang%2C+Liang%3BZhang%2C+Lu%3BZhong%2C+Sheng%3BWolfinger%2C+Russell+D%3BTong%2C+Weida&rft.aulast=Shi&rft.aufirst=Leming&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Statistics; Quality control; Discordance; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S10 ER - TY - JOUR T1 - Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of Influenza A virus strain AN - 20349193; 9023642 AB - Background Two nuclear localization sequences (NLS) in influenza A virus nucleoprotein (NP) have been demonstrated to be critical for nuclear import of NP and viral ribonucleoprotein complexes. However, a deletion mutant lacking these two signals was still able to localize to the nucleus suggesting the presence of yet another (a third) potential NLS in the NP protein. In order to identify the nature of this potential NLS signal in the NP of a WS/33L influenza virus A strain, we utilized the tools of bioinformatics coupled with functional experimental analyses in the present study. Results Comparison of the deduced aa sequence of NP of WS/33L strain with the published WS/33 NP sequences revealed that a single amino acid (aa) change (Met to Arg) at position 105 results in converting the flanking regions (between aa position 90-121, a 32-residue stretch) into two classical overlapping bipartite NLS (obpNLS). GenBank search revealed that 9 out of 500 published NP sequences contain a similar Arg at position 105 (instead of Met) with a 100% homology to the obpNLS region. Various NP-green fluorescent protein (GFP) fusion constructs with and without the signal (obpNLS-Arg super(105)) were utilized to understand the functional nature of this signal. We analyzed the transport competency of the expressed chimeric proteins in terms of their cellular localization by confocal immunofluorescence assay. Our analysis revealed that all NP-GFP constructs containing the wild-type (R super(105)) sequence localized predominantly to the nucleus. Constructs lacking the obpNLS or constructs with reverse mutation (R super(105 )to M super(105)) on the other hand exhibited predominant cytoplasmic localization pattern. Interestingly, when the 32 aa obpNLS was fused with an unrelated viral protein (rotavirus NSP6) that has been known to be cytoplasmic protein, the chimeric protein (obpNLS-NSP6) was efficiently transported into the nucleus, indicating an efficient nuclear transport function of the 32-residue obpNLS in the NP of WS/33L strain of influenza A virus. Conclusion This report while not only establishing a new NLS in the influenza A virus strain, it also reinforces the idea that proper application of bioinformatics-coupled experimental analysis serves as a powerful tool in identifying new functional signals in proteins of interest. JF - BMC Cell Biology AU - Ketha, Krishna Mohan V AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (F.D.A.) Bethesda, MD 20892, USA, krishna.ketha@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 22 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Rotavirus KW - Deletion mutant KW - double prime NP protein KW - Nucleoproteins KW - Immunofluorescence KW - Methionine KW - Nuclear transport KW - Homology KW - Influenza A virus KW - Ribonucleoproteins KW - Bioinformatics KW - Fusion protein KW - Mutation KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Cell+Biology&rft.atitle=Application+of+bioinformatics-coupled+experimental+analysis+reveals+a+new+transport-competent+nuclear+localization+signal+in+the+nucleoprotein+of+Influenza+A+virus+strain&rft.au=Ketha%2C+Krishna+Mohan+V%3BAtreya%2C+Chintamani+D&rft.aulast=Ketha&rft.aufirst=Krishna+Mohan&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=BMC+Cell+Biology&rft.issn=1471-2121&rft_id=info:doi/10.1186%2F1471-2121-9-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nuclear transport; Deletion mutant; Homology; double prime NP protein; Nucleoproteins; Ribonucleoproteins; Fusion protein; Immunofluorescence; Bioinformatics; Mutation; Methionine; Amino acid sequence; Rotavirus; Influenza A virus DO - http://dx.doi.org/10.1186/1471-2121-9-22 ER - TY - JOUR T1 - Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples AN - 20346885; 9023576 AB - Background Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as disease status and drug response. Highly accurate and reproducible genotype calling are paramount since errors introduced by calling algorithms can lead to inflation of false associations between genotype and phenotype. Most genotype calling algorithms currently used for GWAS are based on multiple arrays. Because hundreds of gigabytes (GB) of raw data are generated from a GWAS, the samples are typically partitioned into batches containing subsets of the entire dataset for genotype calling. High call rates and accuracies have been achieved. However, the effects of batch size (i.e., number of chips analyzed together) and of batch composition (i.e., the choice of chips in a batch) on call rate and accuracy as well as the propagation of the effects into significantly associated SNPs identified have not been investigated. In this paper, we analyzed both the batch size and batch composition for effects on the genotype calling algorithm BRLMM using raw data of 270 HapMap samples analyzed with the Affymetrix Human Mapping 500 K array set. Results Using data from 270 HapMap samples interrogated with the Affymetrix Human Mapping 500 K array set, three different batch sizes and three different batch compositions were used for genotyping using the BRLMM algorithm. Comparative analysis of the calling results and the corresponding lists of significant SNPs identified through association analysis revealed that both batch size and composition affected genotype calling results and significantly associated SNPs. Batch size and batch composition effects were more severe on samples and SNPs with lower call rates than ones with higher call rates, and on heterozygous genotype calls compared to homozygous genotype calls. Conclusion Batch size and composition affect the genotype calling results in GWAS using BRLMM. The larger the differences in batch sizes, the larger the effect. The more homogenous the samples in the batches, the more consistent the genotype calls. The inconsistency propagates to the lists of significantly associated SNPs identified in downstream association analysis. Thus, uniform and large batch sizes should be used to make genotype calls for GWAS. In addition, samples of high homogeneity should be placed into the same batch. JF - BMC Bioinformatics AU - Hong, Huixiao AU - Su, Zhenqiang AU - Ge, Weigong AU - Shi, Leming AU - Perkins, Roger AU - Fang, Hong AU - Xu, Joshua AU - Chen, James J AU - Han, Tao AU - Kaput, Jim AU - Fuscoe, James C AU - Tong, Weida AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Huixiao.Hong@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S17 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Association analysis KW - Data processing KW - Vocalization behavior KW - Single-nucleotide polymorphism KW - Genotyping KW - Algorithms KW - Genotypes KW - Bioinformatics KW - Drugs KW - Gene mapping KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Assessing+batch+effects+of+genotype+calling+algorithm+BRLMM+for+the+Affymetrix+GeneChip+Human+Mapping+500+K+array+set+using+270+HapMap+samples&rft.au=Hong%2C+Huixiao%3BSu%2C+Zhenqiang%3BGe%2C+Weigong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BFang%2C+Hong%3BXu%2C+Joshua%3BChen%2C+James+J%3BHan%2C+Tao%3BKaput%2C+Jim%3BFuscoe%2C+James+C%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Association analysis; Data processing; Vocalization behavior; Single-nucleotide polymorphism; Genotyping; Algorithms; Bioinformatics; Genotypes; Drugs; Gene mapping DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S17 ER - TY - JOUR T1 - Very Important Pool (VIP) genes - an application for microarray-based molecular signatures AN - 20346609; 9023587 AB - Background Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine. Derivation of biomarkers is a large step beyond hypothesis generation and imposes considerably more stringency for accuracy in identifying informative gene subsets to differentiate phenotypes. The inherent nature of microarray data, with fewer samples and replicates compared to the large number of genes, requires identifying informative genes prior to classifier construction. However, improving the ability to identify differentiating genes remains a challenge in bioinformatics. Results A new hybrid gene selection approach was investigated and tested with nine publicly available microarray datasets. The new method identifies a Very Important Pool (VIP) of genes from the broad patterns of gene expression data. The method uses a bagging sampling principle, where the re-sampled arrays are used to identify the most informative genes. Frequency of selection is used in a repetitive process to identify the VIP genes. The putative informative genes are selected using two methods, t-statistic and discriminatory analysis. In the t-statistic, the informative genes are identified based on p-values. In the discriminatory analysis, disjoint Principal Component Analyses (PCAs) are conducted for each class of samples, and genes with high discrimination power (DP) are identified. The VIP gene selection approach was compared with the p-value ranking approach. The genes identified by the VIP method but not by the p-value ranking approach are also related to the disease investigated. More importantly, these genes are part of the pathways derived from the common genes shared by both the VIP and p-ranking methods. Moreover, the binary classifiers built from these genes are statistically equivalent to those built from the top 50 p-value ranked genes in distinguishing different types of samples. Conclusion The VIP gene selection approach could identify additional subsets of informative genes that would not always be selected by the p-value ranking method. These genes are likely to be additional true positives since they are a part of pathways identified by the p-value ranking method and expected to be related to the relevant biology. Therefore, these additional genes derived from the VIP method potentially provide valuable biological insights. JF - BMC Bioinformatics AU - Su, Zhenqiang AU - Hong, Huixiao AU - Fang, Hong AU - Shi, Leming AU - Perkins, Roger AU - Tong, Weida AD - Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA, zhenqiang.su@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S9 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Principal components analysis KW - Hybrids KW - Bioinformatics KW - Sampling KW - Vasoactive intestinal peptide KW - DNA microarrays KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Very+Important+Pool+%28VIP%29+genes+-+an+application+for+microarray-based+molecular+signatures&rft.au=Su%2C+Zhenqiang%3BHong%2C+Huixiao%3BFang%2C+Hong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Su&rft.aufirst=Zhenqiang&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Hybrids; Principal components analysis; Sampling; Bioinformatics; biomarkers; DNA microarrays; Vasoactive intestinal peptide DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S9 ER - TY - JOUR T1 - Prospective study of physical activity and risk of postmenopausal breast cancer AN - 20270744; 8921933 AB - Introduction To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk. Methods We studied 32,269 women enrolled in the Breast Cancer Detection Demonstration Project Follow-up Study. Usual physical activity (including household, occupational and leisure activities) throughout the previous year was assessed at baseline using a self-administered questionnaire. Postmenopausal breast cancer cases were identified through self-reports, death certificates and linkage to state cancer registries. A Cox proportional hazards regression was used to estimate the relative risk and 95% confidence intervals of postmenopausal breast cancer associated with physical activity. Results During 269,792 person-years of follow-up from 1987 to 1998, 1506 new incident cases of postmenopausal breast cancer were ascertained. After adjusting for potential risk factors of breast cancer, a weak inverse association between total physical activity and postmenopausal breast cancer was suggested (relative risk comparing extreme quintiles = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.21). That relation was almost entirely contributed by vigorous activity (relative risk comparing extreme categories = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.08). The inverse association with vigorous activity was limited to women who were lean (ie, body mass index &25.0 kg/m super(2): relative risk = 0.68; 95% confidence interval = 0.54 to 0.85). In contrast, no association with vigorous activity was noted among women who were overweight or obese (ie, body mass index greater than or equal to 25.0 kg/m super(2): relative risk = 1.18; 95% confidence interval = 0.93 to 1.49; p for interaction = 0.008). Non-vigorous activity showed no relation to breast cancer (relative risk comparing extreme quintiles = 1.02; 95% confidence interval = 0.87 to 1.19; p for trend = 0.86). The physical activity and breast cancer relation was not specific to a certain hormone receptor subtype. Conclusions In this cohort of postmenopausal women, breast cancer risk reduction appeared to be limited to vigorous forms of activity; it was apparent among normal weight women but not overweight women, and the relation did not vary by hormone receptor status. Our findings suggest that physical activity acts through underlying biological mechanisms that are independent of body weight control. JF - Breast Cancer Research AU - Leitzmann, Michael F AU - Moore, Steven C AU - Peters, Tricia M AU - Lacey, James V AU - Schatzkin, Arthur AU - Schairer, Catherine AU - Brinton, Louise A AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd., MSC 7232, Bethesda, MD 20892, USA, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2008 PY - 2008 DA - 2008 SP - R92 PB - BioMed Central Ltd., Middlesex House VL - 10 IS - 5 SN - 1465-5411, 1465-5411 KW - Physical Education Index KW - Obesity KW - Body mass KW - Women KW - Breasts KW - Exercise KW - Activities KW - Trends KW - Hormones KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20270744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Prospective+study+of+physical+activity+and+risk+of+postmenopausal+breast+cancer&rft.au=Leitzmann%2C+Michael+F%3BMoore%2C+Steven+C%3BPeters%2C+Tricia+M%3BLacey%2C+James+V%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BBrinton%2C+Louise+A%3BAlbanes%2C+Demetrius&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=R92&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research&rft.issn=14655411&rft_id=info:doi/10.1186%2Fbcr2190 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Body mass; Women; Breasts; Exercise; Trends; Activities; Hormones; Cancer DO - http://dx.doi.org/10.1186/bcr2190 ER - TY - JOUR T1 - Physicochemical Characteristics of Aerosol Particles Generated During the Milling of Beryllium Silicate Ores: Implications for Risk Assessment AN - 20239663; 8762249 AB - Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 kg/m super(3) (beryl ore grinding) to 2.1 kg/m super(3) (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were 80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Stefaniak, AB AU - Chipera, S J AU - Day, G A AU - Sabey, P AU - Dickerson, R M AU - Sbarra, D C AU - Duling, M G AU - Lawrence, R B AU - Stanton, M L AU - Scripsick, R C AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, AStefaniak@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1468 EP - 1481 VL - 71 IS - 21 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Risk assessment KW - Aerosol particles KW - Heavy metals KW - Particulates KW - Primary production KW - Dust KW - Melting KW - Bioavailability KW - Ores KW - Risk factors KW - Alloys KW - oxides KW - alloys KW - Occupational exposure KW - Berylliosis KW - Metals KW - Aerosols KW - Surface area KW - Physicochemical properties KW - Silicic acid KW - Alveoli KW - hydroxides KW - Ceramics KW - Lung KW - Beryllium KW - Drumming KW - Minerals KW - surface area KW - R2 23080:Industrial and labor KW - M2 551.510.42:Air Pollution (551.510.42) KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Physicochemical+Characteristics+of+Aerosol+Particles+Generated+During+the+Milling+of+Beryllium+Silicate+Ores%3A+Implications+for+Risk+Assessment&rft.au=Stefaniak%2C+AB%3BChipera%2C+S+J%3BDay%2C+G+A%3BSabey%2C+P%3BDickerson%2C+R+M%3BSbarra%2C+D+C%3BDuling%2C+M+G%3BLawrence%2C+R+B%3BStanton%2C+M+L%3BScripsick%2C+R+C&rft.aulast=Stefaniak&rft.aufirst=AB&rft.date=2008-01-01&rft.volume=71&rft.issue=21&rft.spage=1468&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390802349883 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Berylliosis; Inhalation; Aerosols; Heavy metals; Surface area; Silicic acid; Physicochemical properties; Primary production; Dust; Alveoli; Ceramics; Melting; Bioavailability; Ores; Lung; Risk factors; Beryllium; Drumming; oxides; alloys; Minerals; Occupational exposure; Aerosol particles; Metals; Particulates; hydroxides; Alloys; surface area DO - http://dx.doi.org/10.1080/15287390802349883 ER - TY - JOUR T1 - Hydrophilic Fungi and Ergosterol Associated with Respiratory Illness in a Water-Damaged Building AN - 20197925; 8044956 AB - Background: Damp building-related respiratory illnesses are an important public health issue. Objective: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with post-occupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. Methods: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity greater than or equal to 0.9), and ergosterol with the health outcomes using logistic regression models. Results: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR) = 1.37-1.72], hydrophilic fungi (IQR-OR = 1.45-2.19), and ergosterol (IQR-OR = 1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR = 2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR = 1.54-1.55). Conclusions: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments. JF - Environmental Health Perspectives AU - Park, J-H AU - Cox-Ganser, J M AU - Kreiss, K AU - White, S K AU - Rao, CY AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505 USA, gzp8@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 45 EP - 50 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - demography KW - Endotoxins KW - Historical account KW - Water activity KW - Molds KW - Respiratory diseases KW - Dust KW - Public health KW - Models KW - Demography KW - USA, Washington KW - Dose-response effects KW - Allergens KW - Water-borne diseases KW - Regression analysis KW - Inventories KW - Fungi KW - Asthma KW - Biomass KW - Indoor environments KW - Ergosterol KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins KW - A 01490:Miscellaneous KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20197925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hydrophilic+Fungi+and+Ergosterol+Associated+with+Respiratory+Illness+in+a+Water-Damaged+Building&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J+M%3BKreiss%2C+K%3BWhite%2C+S+K%3BRao%2C+CY&rft.aulast=Park&rft.aufirst=J-H&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Inventories; Fungi; Water activity; Asthma; Molds; Biomass; Dust; Models; Public health; Demography; Allergens; Dose-response effects; Regression analysis; Ergosterol; demography; Historical account; Water-borne diseases; Respiratory diseases; Indoor environments; USA, Washington DO - http://dx.doi.org/10.1289/ehp.10355 ER - TY - JOUR T1 - Estimating the Coverage of a Targeted Mobile Tuberculosis Screening Programme Among Illicit Drug Users and Homeless Persons with Truncated Models AN - 20077768; 8575755 JF - Epidemiology and Infection AU - Van Hest, NAH AU - De Vries, G AU - Smit, F AU - Grant, AD AU - Richardus, J H AD - Tuberculosis Control Section, Municipal Public Health Service Rotterdam- Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2008 PY - 2008 DA - 2008 SP - 628 EP - 635 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 136 IS - 5 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium KW - Tuberculosis KW - Drug abuse KW - Models KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20077768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Estimating+the+Coverage+of+a+Targeted+Mobile+Tuberculosis+Screening+Programme+Among+Illicit+Drug+Users+and+Homeless+Persons+with+Truncated+Models&rft.au=Van+Hest%2C+NAH%3BDe+Vries%2C+G%3BSmit%2C+F%3BGrant%2C+AD%3BRichardus%2C+J+H&rft.aulast=Van+Hest&rft.aufirst=NAH&rft.date=2008-01-01&rft.volume=136&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268807009235 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tuberculosis; Drug abuse; Models; Mycobacterium DO - http://dx.doi.org/10.1017/S0950268807009235 ER - TY - JOUR T1 - Process analytical technology: Non-destructive assessment of anastrozole entrapment within PLGA microparticles by near infrared spectroscopy and chemical imaging AN - 20064105; 10062988 AB - The objective of this study was to evaluate near-infrared (NIR) spectroscopy and imaging as approaches to assess anastrozole entrapment within PLGA microparticles. By varying the polymer concentration, three batches containing the same amount of the drug were prepared. The spectral features that allow NIR drug quantitation were evaluated and compared with a best fit line algorithm. Actual entrapment efficiencies (EEF) determined via a destructive method were used for construction of calibration models using partial least square regression (PLS) or the algorithm. On the other hand, a chemical imaging system based on array detector technology was used to rapidly collect high contrast NIR images of the formulated microparticles. A quantitative measure of anastrozole entrapped was determined by calculating the percentage standard deviation of the distribution of pixel intensities in the PLS score images and histograms. Concerning conventional NIR analysis, both methods were equivalent for the prediction of EEF over the range of polymer levels studied. Correlation coefficients of more than 0.992 were obtained for either the calibration or prediction of EEF by the two methods; 0.392% and 0.374% were the standard errors of calibration and prediction (SEC and SEP) obtained for the prediction of EEF using the fit line, respectively, whereas the prediction of the EEF by the partial least square regression showed a SEC of 0.195% and SEP of 0.179%. As a result, the spectral best fit algorithm method compared favourably to the multivariate PLS method, but was easier to develop. In contrast, NIR spectral imaging was capable of clearly differentiating the three batches, both qualitatively and quantitatively. The percentage standard deviation increased progressively by increasing the ratio of drug-to-polymer concentrations. In conclusion, both NIR approaches were capable of accurate assessment of drug entrapment within microparticles. In addition, the NIR spectral imaging system provides a rapid approach for acquiring spatial and spectral information on microparticles. JF - Journal of Microencapsulation AU - Zidan, A S AU - Sammour, O A AU - Hammad, M A AU - Megrab, N A AU - Habib, M J AU - Khan, M A AD - Division of Product Quality Research, Food and Drug Administration, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 145 EP - 153 PB - Taylor & Francis, 1 Gunpowder Sq. London EC4A UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3 SN - 0265-2048, 0265-2048 KW - Biotechnology and Bioengineering Abstracts KW - Anastrozole KW - I.R. radiation KW - microparticles KW - polylactide-co-glycolide KW - microencapsulation KW - Algorithms KW - spatial discrimination KW - Drug development KW - Drug screening KW - imaging KW - Standard deviation KW - I.R. spectroscopy KW - Regression analysis KW - Drugs KW - Quantitation KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20064105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microencapsulation&rft.atitle=Process+analytical+technology%3A+Non-destructive+assessment+of+anastrozole+entrapment+within+PLGA+microparticles+by+near+infrared+spectroscopy+and+chemical+imaging&rft.au=Zidan%2C+A+S%3BSammour%2C+O+A%3BHammad%2C+M+A%3BMegrab%2C+N+A%3BHabib%2C+M+J%3BKhan%2C+M+A&rft.aulast=Zidan&rft.aufirst=A&rft.date=2008-01-01&rft.volume=25&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microencapsulation&rft.issn=02652048&rft_id=info:doi/10.1080%2F02652040601034963 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; microparticles; Anastrozole; Algorithms; Standard deviation; polylactide-co-glycolide; I.R. spectroscopy; Drug development; spatial discrimination; Drug screening; Regression analysis; I.R. radiation; microencapsulation; Quantitation; Drugs DO - http://dx.doi.org/10.1080/02652040601034963 ER - TY - JOUR T1 - Vancomycin-Resistant Lactococcus lactis 1A-1 Isolated from a Competitive Exclusion Product Transfers Vancomycin Resistance Genes to Staphylococcus aureus AN - 20051022; 8360124 AB - A vancomycin-resistant Lactococcus lactis isolate 1A-1 from a competitive exclusion (CE) product contained plasmid-encoded vanA, B, C1, and C2/3 genes. The L. lactis 1A-1 conjugatively transferred the genes to Staphylococcus aureus in vitro. CE product bacteria may be reservoirs for dissemination of vanA, B, and C genes to the human gastrointestinal microbiota. JF - Open Food Science Journal AU - Wagner, RDoug AU - Kurniasih-Rubin, Dedeh AU - Johnson, Shemedia J AD - Division of Microbiology, National Center for Toxicological Research, HFT-250, 3900 NCTR Rd., Jefferson, AR 72022, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 72 EP - 76 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [URL:http://www.bentham.org] VL - 2 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Lactococcus lactis KW - Vancomycin KW - Staphylococcus aureus KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20051022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open+Food+Science+Journal&rft.atitle=Vancomycin-Resistant+Lactococcus+lactis+1A-1+Isolated+from+a+Competitive+Exclusion+Product+Transfers+Vancomycin+Resistance+Genes+to+Staphylococcus+aureus&rft.au=Wagner%2C+RDoug%3BKurniasih-Rubin%2C+Dedeh%3BJohnson%2C+Shemedia+J&rft.aulast=Wagner&rft.aufirst=RDoug&rft.date=2008-01-01&rft.volume=2&rft.issue=&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Open+Food+Science+Journal&rft.issn=1874-2564&rft_id=info:doi/10.2174%2F1874256400802010072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vancomycin; Lactococcus lactis; Staphylococcus aureus DO - http://dx.doi.org/10.2174/1874256400802010072 ER - TY - JOUR T1 - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells AN - 19989349; 7944480 AB - Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both d-kawain and dl-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation. JF - Food and Chemical Toxicology AU - Whittaker, P AU - Clarke, J J AU - San, RHC AU - Betz, J M AU - Seifried, HE AU - de Jager, LS AU - Dunkel, V C AD - Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States, paul.whittaker@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 168 EP - 174 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 1 SN - 0278-6915, 0278-6915 KW - Genetics Abstracts; Immunology Abstracts; Toxicology Abstracts KW - Shrubs KW - Mutagenicity KW - Chewing KW - Milk KW - Beverages KW - Anxiety KW - Rhizomes KW - Point mutation KW - Roots KW - Toxicity KW - Liver transplantation KW - Anxiolytics KW - Mammalian cells KW - Dietary supplements KW - Piper methysticum KW - Allografts KW - Liver KW - Lymphoma KW - F 06955:Immunomodulation & Immunopharmacology KW - G 07800:Plants and Algae KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19989349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Evaluation+of+commercial+kava+extracts+and+kavalactone+standards+for+mutagenicity+and+toxicity+using+the+mammalian+cell+gene+mutation+assay+in+L5178Y+mouse+lymphoma+cells&rft.au=Whittaker%2C+P%3BClarke%2C+J+J%3BSan%2C+RHC%3BBetz%2C+J+M%3BSeifried%2C+HE%3Bde+Jager%2C+LS%3BDunkel%2C+V+C&rft.aulast=Whittaker&rft.aufirst=P&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Shrubs; Mutagenicity; Beverages; Milk; Chewing; Anxiety; Rhizomes; Point mutation; Roots; Toxicity; Liver transplantation; Anxiolytics; Mammalian cells; Dietary supplements; Allografts; Liver; Lymphoma; Piper methysticum DO - http://dx.doi.org/10.1016/j.fct.2007.07.013 ER - TY - JOUR T1 - Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay AN - 19901128; 8820022 AB - Background The emergence of influenza strains that are resistant to commonly used antivirals has highlighted the need to develop new compounds that target viral gene products or host mechanisms that are essential for effective virus replication. Existing assays to identify potential antiviral compounds often use high throughput screening assays that target specific viral replication steps. To broaden the search for antivirals, cell-based replication assays can be performed, but these are often labor intensive and have limited throughput. Results We have adapted a traditional virus neutralization assay to develop a practical, cell-based, high throughput screening assay. This assay uses viral neuraminidase (NA) as a read-out to quantify influenza replication, thereby offering an assay that is both rapid and sensitive. In addition to identification of inhibitors that target either viral or host factors, the assay allows simultaneous evaluation of drug toxicity. Antiviral activity was demonstrated for a number of known influenza inhibitors including amantadine that targets the M2 ion channel, zanamivir that targets NA, ribavirin that targets IMP dehydrogenase, and bis-indolyl maleimide that targets protein kinase A/C. Amantadine-resistant strains were identified by comparing IC sub(50 )with that of the wild-type virus. Conclusion Antivirals with specificity for a broad range of targets are easily identified in an accelerated viral inhibition assay that uses NA as a read-out of replication. This assay is suitable for high throughput screening to identify potential antivirals or can be used to identify drug-resistant influenza strains. JF - Virology Journal AU - Eichelberger, Maryna C AU - Hassantoufighi, Arash AU - Wu, Meng AU - Li, Min AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, Maryna.Eichelberger@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 109 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1743-422X, 1743-422X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Protein kinase A KW - IMP dehydrogenase KW - Replication KW - Drug resistance KW - Ribavirin KW - Exo-a-sialidase KW - Drug development KW - Toxicity KW - Antiviral activity KW - Zanamivir KW - Influenza KW - Antiviral agents KW - Ion channels KW - Amantadine KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19901128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology+Journal&rft.atitle=Neuraminidase+activity+provides+a+practical+read-out+for+a+high+throughput+influenza+antiviral+screening+assay&rft.au=Eichelberger%2C+Maryna+C%3BHassantoufighi%2C+Arash%3BWu%2C+Meng%3BLi%2C+Min&rft.aulast=Eichelberger&rft.aufirst=Maryna&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Virology+Journal&rft.issn=1743422X&rft_id=info:doi/10.1186%2F1743-422X-5-109 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein kinase A; IMP dehydrogenase; Replication; Drug resistance; Ribavirin; Exo-a-sialidase; Drug development; Toxicity; Antiviral activity; Zanamivir; Influenza; Antiviral agents; Ion channels; Amantadine DO - http://dx.doi.org/10.1186/1743-422X-5-109 ER - TY - JOUR T1 - A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases AN - 19900746; 8522270 AB - Background Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs) are multi-component enzyme systems that are remarkably diverse in bacteria isolated from diverse habitats. Since the first classification in 1990, there has been a need to devise a new classification scheme for these enzymes because many RHOs have been discovered, which do not belong to any group in the previous classification. Here, we present a scheme for classification of RHOs reflecting new sequence information and interactions between RHO enzyme components. Result We have analyzed a total of 130 RHO enzymes in which 25 well-characterized RHO enzymes were used as standards to test our hypothesis for the proposed classification system. From the sequence analysis of electron transport chain (ETC) components of the standard RHOs, we extracted classification keys that reflect not only the phylogenetic affiliation within each component but also relationship among components. Oxygenase components of standard RHOs were phylogenetically classified into 10 groups with the classification keys derived from ETC components. This phylogenetic classification scheme was converted to a new systematic classification consisting of 5 distinct types. The new classification system was statistically examined to justify its stability. Type I represents two-component RHO systems that consist of an oxygenase and an FNR sub(C)-type reductase. Type II contains other two-component RHO systems that consist of an oxygenase and an FNR sub(N)-type reductase. Type III represents a group of three-component RHO systems that consist of an oxygenase, a [2Fe-2S]-type ferredoxin and an FNR sub(N)-type reductase. Type IV represents another three-component systems that consist of oxygenase, [2Fe-2S]-type ferredoxin and GR-type reductase. Type V represents another different three-component systems that consist of an oxygenase, a [3Fe-4S]-type ferredoxin and a GR-type reductase. Conclusion The new classification system provides the following features. First, the new classification system analyzes RHO enzymes as a whole. RwithSecond, the new classification system is not static but responds dynamically to the growing pool of RHO enzymes. Third, our classification can be applied reliably to the classification of incomplete RHOs. Fourth, the classification has direct applicability to experimental work. Fifth, the system provides new insights into the evolution of RHO systems based on enzyme interaction. JF - BMC Biochemistry AU - Kweon, Ohgew AU - Kim, Seong-Jae AU - Baek, Songjoon AU - Chae, Jong-Chan AU - Adjei, Michael D AU - Baek, Dong-Heon AU - Kim, Young-Chang AU - Cerniglia, Carl E AD - Microbiology Division, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA, oh-gew.kweon@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 11 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Classification systems KW - Bacteria KW - Enzymes KW - Habitat KW - Ferredoxin KW - Keys KW - reductase KW - Classification KW - Iron KW - Oxygenase KW - Evolution KW - Aromatics KW - Electron transport chain KW - J 02310:Genetics & Taxonomy KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biochemistry&rft.atitle=A+new+classification+system+for+bacterial+Rieske+non-heme+iron+aromatic+ring-hydroxylating+oxygenases&rft.au=Kweon%2C+Ohgew%3BKim%2C+Seong-Jae%3BBaek%2C+Songjoon%3BChae%2C+Jong-Chan%3BAdjei%2C+Michael+D%3BBaek%2C+Dong-Heon%3BKim%2C+Young-Chang%3BCerniglia%2C+Carl+E&rft.aulast=Kweon&rft.aufirst=Ohgew&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=BMC+Biochemistry&rft.issn=1471-2091&rft_id=info:doi/10.1186%2F1471-2091-9-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Classification systems; Phylogeny; Enzymes; Habitat; Ferredoxin; Keys; reductase; Classification; Oxygenase; Iron; Aromatics; Evolution; Electron transport chain; Bacteria DO - http://dx.doi.org/10.1186/1471-2091-9-11 ER - TY - JOUR T1 - An investigation of hand forces and postures for using selected mechanical pipettes AN - 19804331; 8549446 AB - The present study evaluated thumb, hand forces, wrist, forearm and shoulder postures used for pipetting with three selected mechanical pipettes. Twelve pipette users in a large university health system participated in pipetting simulation in their own laboratories to investigate the effects of pipette type, body posture (standing/seated), sample volume (200/1000 is a subset of L) and pipetting task on the physical risk factors. The thumb and hand forces were measured with 19 Flexiforce(TM) sensors. Wrist and forearm postures were measured with an electrogoniometer and a torsiometer, respectively. Humeral elevation as shoulder postural stress was assessed by observations from videos recorded during pipetting simulation. The study results showed several advantages of using the non-axial pipette over the traditional axial ones. The non-axial pipette was associated with approximately 2-6 times less thumb and hand force than the traditional axial pipettes. In addition, there were approximately 20-30% reductions in ulnar deviation and 30-70% reductions in humeral elevation to operate the non-axial pipette for most of the pipetting actions. One disadvantage of using the non-axial pipette appears to be increased forearm pronation by approximately 100-150% for the entire pipetting cycle, as compared to the axial pipettes. The results of the study may provide useful information regarding design of pipettes for reducing physical risk factors associated with pipetting. Relevance to industry This paper demonstrated hand forces and postures for common pipetting tasks with selected mechanical pipettes. The hand force and postural data for using axial and non-axial pipettes may provide key information for hand injury prevention due to pipetting in the industry. JF - International Journal of Industrial Ergonomics AU - Lu, Ming-Lun AU - James, Tamara AU - Lowe, Brian AU - Barrero, Marisol AU - Kong, Yong-Ku AD - National Institute for Occupational Safety and Health, Taft Laboratories, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226, USA, mlu@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 18 EP - 29 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 1 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Sensors KW - Injuries KW - prevention KW - Ergonomics KW - Stress KW - Simulation KW - Working conditions KW - Occupational health KW - posture KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=An+investigation+of+hand+forces+and+postures+for+using+selected+mechanical+pipettes&rft.au=Lu%2C+Ming-Lun%3BJames%2C+Tamara%3BLowe%2C+Brian%3BBarrero%2C+Marisol%3BKong%2C+Yong-Ku&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - posture; Occupational health; Working conditions; Simulation; prevention; Ergonomics; Stress; Injuries; Sensors DO - http://dx.doi.org/10.1016/j.ergon.2007.08.006 ER - TY - JOUR T1 - Asthma arising in flavoring-exposed food production workers AN - 19803739; 8572082 AB - Objectives: While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease. Materials and Methods: We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers. Results: Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers. JF - International Journal of Occupational Medicine and Environmental Health AU - Sahakian, N AU - Kullman, G AU - Lynch, D AU - Kreiss, K AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Suite H2800, Morgantown, West Virginia, USA, 26505, KKreiss@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 173 EP - 177 VL - 21 IS - 2 SN - 1232-1087, 1232-1087 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Food KW - Acetaldehyde KW - Mass spectrometry KW - Flavorings KW - Respiratory diseases KW - Chest KW - Mass spectroscopy KW - Workers KW - occupational diseases KW - Gas chromatography KW - Air sampling KW - bronchiolitis obliterans KW - Occupational exposure KW - Data processing KW - Desorption KW - Acetoin KW - medical records KW - Lung diseases KW - Asthma KW - Diacetyl KW - Lung KW - Reviews KW - volatile organic compounds KW - Aldehydes KW - Volatile organic compounds KW - R2 23080:Industrial and labor KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19803739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.atitle=Asthma+arising+in+flavoring-exposed+food+production+workers&rft.au=Sahakian%2C+N%3BKullman%2C+G%3BLynch%2C+D%3BKreiss%2C+K&rft.aulast=Sahakian&rft.aufirst=N&rft.date=2008-01-01&rft.volume=21&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.issn=12321087&rft_id=info:doi/10.2478%2Fv10001-008-0019-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Desorption; Data processing; Acetoin; medical records; Acetaldehyde; Food; Lung diseases; Asthma; Flavorings; Chest; Diacetyl; Mass spectroscopy; Workers; Gas chromatography; Reviews; volatile organic compounds; bronchiolitis obliterans; Aldehydes; Occupational exposure; Chemicals; Mass spectrometry; Respiratory diseases; occupational diseases; Lung; Air sampling; Volatile organic compounds DO - http://dx.doi.org/10.2478/v10001-008-0019-1 ER - TY - JOUR T1 - Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells AN - 19792685; 8493289 AB - Carbon nanotubes are new tools in industry and medicine with their potential applications in many uses. Multiwall carbon nanotubes (MWCNT) with their morphologic similarity to asbestos and wide commercial and biomedical applications necessitate these investigations. The present study investigated the biological reactivity of MWCNT in normal (NM) and malignant (MM) mesothelial cells. MWCNT containing low iron content generated only negligible amounts of reactive oxygen species with both cells. Exposure of both cell types to MWCNT caused cell death, cytotoxicity, DNA damage and apoptosis, which were greater in MM cells. Exposure of both cells to MWCNT caused a parallel activation of two important transcription factors, phosphorylation of H2AX, and PARP activation which were greater in NM cells. Phosphorylation of ERK1/2 and p38 was greater in MM cells than in NM cells. These findings demonstrate that MWCNT are biologically potent activators of molecular events in NM cells associated with mesothelioma development. JF - Nanotoxicology AU - Pacurari, M AU - Yin, X J AU - Ding, M AU - Leonard, S S AU - Schwegler-Berry, D AU - Ducatman, B S AU - Chirila, M AU - Endo, M AU - Castranova, V AU - Vallyathan, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 155 EP - 170 VL - 2 IS - 3 SN - 1743-5390, 1743-5390 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Asbestos KW - Apoptosis KW - Extracellular signal-regulated kinase KW - DNA damage KW - Cytotoxicity KW - Carbon KW - Reactive oxygen species KW - Phosphorylation KW - Poly(ADP-ribose) polymerase KW - Transcription factors KW - mesothelioma KW - nanotubes KW - Iron KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19792685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Oxidative+and+molecular+interactions+of+multi-wall+carbon+nanotubes+%28MWCNT%29+in+normal+and+malignant+human+mesothelial+cells&rft.au=Pacurari%2C+M%3BYin%2C+X+J%3BDing%2C+M%3BLeonard%2C+S+S%3BSchwegler-Berry%2C+D%3BDucatman%2C+B+S%3BChirila%2C+M%3BEndo%2C+M%3BCastranova%2C+V%3BVallyathan%2C+V&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Asbestos; Apoptosis; DNA damage; Extracellular signal-regulated kinase; Cytotoxicity; Carbon; Phosphorylation; Reactive oxygen species; Transcription factors; Poly(ADP-ribose) polymerase; nanotubes; mesothelioma; Iron DO - http://dx.doi.org/10.1080/17435390802318356 ER - TY - JOUR T1 - Optical mapping and 454 sequencing of Escherichia coli O157 : H7 isolates linked to the US 2006 spinach-associated outbreak AN - 19750221; 8605192 AB - Optical maps for five representative clinical, food-borne and bovine- derived isolates from the 2006 Escherichia coli O157 : H7 outbreak linked to fresh spinach in the United States showed a common set of 14 distinct chromosomal markers that define the outbreak strain. Partial 454 DNA sequencing was used to characterize the optically mapped chromosomal markers. The markers included insertions, deletions, substitutions and a simple single nucleotide polymorphism creating a BamHI site. The Shiga toxin gene profile of the spinach-associated outbreak isolates (stx1 super(-) stx2 super(+) stx2c super(+)) correlated with prophage insertions different from those in the prototypical EDL933 and Sakai reference strains (stx1 super(+) stx2 super(+) stx2c super(-)). The prophage occupying the yehV chromosomal position in the spinach-associated outbreak isolates was similar to the stx1 super(+) EDL933 cryptic prophage V, but it lacked the stx1 gene. In EDL933, the stx2 genes are within prophage BP933-W at the wrbA chromosomal locus; this locus was unoccupied in the spinach outbreak isolates. Instead, the stx2 genes were found within a chimeric BP933-W-like prophage with a different integrase, inserted at the argW locus in the outbreak isolates. An extra set of Shiga toxin genes, stx2c, was found in the outbreak isolates within a prophage integrated at the sbcB locus. The optical maps of two additional clinical isolates from the outbreak showed a single, different prophage variation in each, suggesting that changes occurred in the source strain during the course of this widespread, multi-state outbreak. JF - Microbiology AU - Kotewicz, Michael L AU - Mammel, Mark K AU - LeClerc, JEugene AU - Cebula, Thomas A Y1 - 2008 PY - 2008 DA - 2008 SP - 3518 EP - 3528 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 154 IS - 11 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Food KW - Prophages KW - DNA sequencing KW - Gene deletion KW - stx1 gene KW - Single-nucleotide polymorphism KW - Escherichia coli KW - Spinacia oleracea KW - Shiga toxin KW - Gene mapping KW - Integrase KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19750221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Optical+mapping+and+454+sequencing+of+Escherichia+coli+O157+%3A+H7+isolates+linked+to+the+US+2006+spinach-associated+outbreak&rft.au=Kotewicz%2C+Michael+L%3BMammel%2C+Mark+K%3BLeClerc%2C+JEugene%3BCebula%2C+Thomas+A&rft.aulast=Kotewicz&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=154&rft.issue=11&rft.spage=3518&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.2008%2F019026-0 L2 - http://mic.sgmjournals.org/cgi/reprint/154/11/3518.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Gene deletion; DNA sequencing; Single-nucleotide polymorphism; stx1 gene; Food; Shiga toxin; Prophages; Integrase; Gene mapping; Escherichia coli; Spinacia oleracea DO - http://dx.doi.org/10.1099/mic.0.2008/019026-0 ER - TY - JOUR T1 - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES AN - 19725741; 9042745 AB - Objectives This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m super(2)) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004 has been accompanied with fewer overweight people perceiving themselves as overweight. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Johnson-Taylor, Wendy L AU - Fisher, Rachel A AU - Hubbard, Van S AU - Starke-Reed, Pamela AU - Eggers, Paul S AD - US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, MD, USA, wj50v@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 9 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1479-5868, 1479-5868 KW - Physical Education Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=The+change+in+weight+perception+of+weight+status+among+the+overweight%3A+comparison+of+NHANES+III+%281988-1994%29+and+1999-2004+NHANES&rft.au=Johnson-Taylor%2C+Wendy+L%3BFisher%2C+Rachel+A%3BHubbard%2C+Van+S%3BStarke-Reed%2C+Pamela%3BEggers%2C+Paul+S&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-5-9 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1479-5868-5-9 ER - TY - JOUR T1 - Racial/Ethnic Minority Children's Use of Psychiatric Emergency Care in California's Public Mental Health System AN - 19716016; 7932432 AB - OBJECTIVES: We examined rates and intensity of crisis services use by race/ethnicity for 351174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. METHODS: We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). RESULTS: African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. CONCLUSIONS: African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits. JF - American Journal of Public Health AU - Snowden, Lonnie R AU - Masland, Mary C AU - Libby, Anne M AU - Wallace, Neal AU - Fawley, Kya AD - Lonnie R. Snowden, Mary C. Masland, and Kya Fawley are with the Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley. Anne M. Libby is with the Department of Psychiatry, School of Medicine, University of Colorado, Denver, and Health Sciences Center, Denver. Neal Wallace is with the Mark O. Hatfield School of Government, Portland State University, Portland, Ore Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 118 EP - 124 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 98 IS - 1 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - Health care KW - INE, USA, California KW - crisis intervention KW - INE, USA, Alaska KW - Children KW - community involvement KW - Ethnic groups KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Racial%2FEthnic+Minority+Children%27s+Use+of+Psychiatric+Emergency+Care+in+California%27s+Public+Mental+Health+System&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BLibby%2C+Anne+M%3BWallace%2C+Neal%3BFawley%2C+Kya&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2008-01-01&rft.volume=98&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Health care; crisis intervention; Children; community involvement; Ethnic groups; Public health; INE, USA, California; INE, USA, Alaska ER - TY - JOUR T1 - Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections AN - 19715391; 8568580 AB - Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United States. Three antimicrobial panels, including 6 classes and 32 antimicrobial agents, were used. A wide range of susceptibility patterns were noted with some isolates being resistant to between 8 and 28 (mean 16) of the antimicrobials tested. Among the b-lactams, all isolates were resistant to ampicillin, cefoxitin, cefpodoxime, cephalothin and cefazolin followed by amoxicillin/clavulanic acid (99%), ceftiofur (97%), ceftriaxone (39%), cefotaxime (26%), and cefotaxime/clavulanic acid (20%), whereas less than 7% of isolates were resistant to ceftazidime/clavulanic acid, ceftazidime, piperacillin/tazobactam or cefepime. Two isolates were resistant to the carbapenems. Among the quinolones and fluoroquinolones, the most isolates were resistant to naladixic acid (96%), followed by orbifloxacin (52%), difloxacin (43%), enrofloxacin (31%), marbofloxacin (27%), gatifloxacin (23%), levofloxacin (21%), and ciprofloxacin (16%). Among the aminoglycosides, the most resistance was seen to kanamycin (90%), followed by streptomycin (69%), gentamicin (7%), and amikacin (3%). Of the remaining antimicrobials 100% of the isolates were resistant to chloramphenicol followed by tetracycline (98%), trimethoprim/sulfamethoxazole (57%), and sulfisoxazole (51%). Point mutations were present in gyrA, gyrB, parC, and/or parE genes among 34 of the 102 naladixic acid-resistant isolates. Two isolates contained class 1 integrons carrying aadA gene conferring streptomycin and spectinomycin resistance. The findings suggest that many antimicrobial agents commonly used in companion animals may not constitute appropriate therapy for canine pseudomonas infections. JF - Veterinary Microbiology AU - Rubin, J AU - Walker, R D AU - Blickenstaff, K AU - Bodeis-Jones, S AU - Zhao, S AD - Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Canada, shaohua.zhao@FDA.HHS.GOV Y1 - 2008 PY - 2008 DA - 2008 SP - 164 EP - 172 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 131 IS - 1-2 SN - 0378-1135, 0378-1135 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Pseudomonas aeruginosa KW - Antimicrobial resistance KW - Fluoroquinolones KW - Canine KW - Class 1 integron KW - QRDR KW - Trimethoprim KW - Amikacin KW - Difloxacin KW - Drug resistance KW - Levofloxacin KW - Quinolones KW - Streptomycin KW - Infection KW - Cefpodoxime KW - DNA topoisomerase IV KW - Ceftazidime KW - Ciprofloxacin KW - Clavulanic acid KW - Pyoderma KW - Cefoxitin KW - Chloramphenicol KW - Cefotaxime KW - Sulfamethoxazole KW - DNA topoisomerase KW - b-Lactam antibiotics KW - Tazobactam KW - Ceftriaxone KW - Antimicrobial agents KW - Gatifloxacin KW - Gentamicin KW - Cefazolin KW - Otitis KW - Spectinomycin KW - Piperacillin KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19715391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Antimicrobial+resistance+and+genetic+characterization+of+fluoroquinolone+resistance+of+Pseudomonas+aeruginosa+isolated+from+canine+infections&rft.au=Rubin%2C+J%3BWalker%2C+R+D%3BBlickenstaff%2C+K%3BBodeis-Jones%2C+S%3BZhao%2C+S&rft.aulast=Rubin&rft.aufirst=J&rft.date=2008-01-01&rft.volume=131&rft.issue=1-2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2008.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Trimethoprim; Difloxacin; Amikacin; Levofloxacin; Drug resistance; Quinolones; Streptomycin; Infection; Cefpodoxime; DNA topoisomerase IV; Ceftazidime; Ciprofloxacin; Clavulanic acid; Pyoderma; Cefoxitin; Chloramphenicol; Cefotaxime; Sulfamethoxazole; Fluoroquinolones; b-Lactam antibiotics; DNA topoisomerase; Tazobactam; Ceftriaxone; Gatifloxacin; Antimicrobial agents; Gentamicin; Cefazolin; Otitis; Spectinomycin; Piperacillin; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.vetmic.2008.02.018 ER - TY - JOUR T1 - Inactivated influenza vaccine (IIV) in children <2 years of age: Examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine AN - 19687288; 8554385 AB - Thimerosal as a preservative (in all but trace amounts) was removed from vaccines used in infants starting in the late 1990s, though the preservative- including inactivated influenza vaccine is still available for use in individuals >=6 months of age. We compared the proportion of injection site reactions, rash, and infections reported to the Vaccine Adverse Event Reporting System (VAERS) after preservative-free (PFV), preservative- including (PIV), and preservative unknown (PUV) vaccines in reports from 7/1/2004 to 1/4/2006. There were 145, 175, and 216 reports after vaccination with PFV, PIV, and PUV, respectively. The most frequently reported coding terms (fever, rash, and urticaria) were seen in similar proportions in the PFV, PIV, and PUV groups. No difference was detected in the proportion of injection site reactions (ISR), rash, or infections in the PIV, PFV, and PUV reports. Keeping in mind the inherent limitations of VAERS, including underreporting and potential reporting biases, we conclude that there were no substantial differences in the proportion of rash, ISR, and infection reports in the PIV, PFV and PUV reports in infants. JF - Vaccine AU - McMahon, A W AU - Iskander, J K AU - Haber, P AU - Braun, M M AU - Ball, R AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, USA, ann.mcmahon@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 427 EP - 429 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 3 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Influenza vaccine KW - Adverse event KW - Thimerosal KW - Infant KW - thimerosal KW - vaccines KW - Age KW - Urticaria KW - Infection KW - Children KW - influenza KW - Influenza KW - Fever KW - Exanthema KW - infection KW - Vaccines KW - Preservatives KW - Infants KW - F 06925:Hypersensitivity KW - V 22350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Inactivated+influenza+vaccine+%28IIV%29+in+children+%26lt%3B2+years+of+age%3A+Examination+of+selected+adverse+events+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29+after+thimerosal-free+or+thimerosal-containing+vaccine&rft.au=McMahon%2C+A+W%3BIskander%2C+J+K%3BHaber%2C+P%3BBraun%2C+M+M%3BBall%2C+R&rft.aulast=McMahon&rft.aufirst=A&rft.date=2008-01-01&rft.volume=26&rft.issue=3&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.10.071 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - thimerosal; Fever; Influenza; Exanthema; Age; Urticaria; Vaccines; Children; Infection; Preservatives; Infants; vaccines; infection; influenza DO - http://dx.doi.org/10.1016/j.vaccine.2007.10.071 ER - TY - JOUR T1 - Analysis of musculoskeletal loading in an index finger during tapping AN - 19636099; 8793087 AB - Since musculoskeletal disorders of the upper extremities are believed to be associated with repetitive excessive muscle force production in the hands, understanding the time-dependent muscle forces during key tapping is essential for exploring the mechanisms of disease initiation and development. In the current study, we have simulated the time-dependent dynamic loading in the muscle/tendons in an index finger during tapping. The index finger model is developed using a commercial software package AnyBody, and it contains seven muscle/tendons that connect the three phalangeal finger sections. Our simulations indicate that the ratios of the maximal forces in flexor digitorum superficialis (FS) and flexor digitorum profundus (FP) tendons to the maximal force at the fingertip are 0.95 and 2.9, respectively, which agree well with recently published experimental data. The time sequence of the finger muscle activation predicted in the current study is consistent with the EMG data in the literature. The proposed model will be useful for bioengineers and ergonomic designers to improve keyboard design minimizing musculoskeletal loadings in the fingers. JF - Journal of Biomechanics AU - Wu, John Z AU - An, Kai-Nan AU - Cutlip, Robert G AU - Krajnak, Kristine AU - Welcome, Daniel AU - Dong, Ren G AD - National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA, jwu@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 668 EP - 676 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 41 IS - 3 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Index finger KW - Muscle force KW - Muscle-tendon excursion KW - Tapping KW - Simulations KW - biomechanics KW - Muscles KW - Simulation KW - musculoskeletal system KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19636099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Analysis+of+musculoskeletal+loading+in+an+index+finger+during+tapping&rft.au=Wu%2C+John+Z%3BAn%2C+Kai-Nan%3BCutlip%2C+Robert+G%3BKrajnak%2C+Kristine%3BWelcome%2C+Daniel%3BDong%2C+Ren+G&rft.aulast=Wu&rft.aufirst=John&rft.date=2008-01-01&rft.volume=41&rft.issue=3&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2007.09.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - biomechanics; Muscles; Simulation; Ergonomics; musculoskeletal system DO - http://dx.doi.org/10.1016/j.jbiomech.2007.09.025 ER - TY - JOUR T1 - Preventable Mix-ups of Tuberculin and Vaccines: Reports to the US Vaccine and Drug Safety Reporting Systems AN - 19634720; 8806586 AB - Background: Errors involving the mix-up of tuberculin purified protein derivative (PPD) and vaccines leading to adverse reactions and unnecessary medical management have been reported previously. Objectives: To determine the frequency of PPD-vaccine mix-ups reported to the US Vaccine Adverse Event Reporting System (VAERS) and the Adverse Event Reporting System (AERS), characterize adverse events and clusters involving mix-ups and describe reported contributory factors. Methods: We reviewed AERS reports from 1969 to 2005 and VAERS reports from 1990 to 2005. We defined a mix-up error event as an incident in which a single patient or a cluster of patients inadvertently received vaccine instead of a PPD product or received a PPD product instead of vaccine. We defined a cluster as inadvertent administration of PPD or vaccine products to more than one patient in the same facility within 1 month. Results: Of 115 mix-up events identified, 101 involved inadvertent administration of vaccines instead of PPD. Product confusion involved PPD and multiple vaccines. The annual number of reported mix-ups increased from an average of one event per year in the early 1990s to an average of ten events per year in the early part of this decade. More than 240 adults and children were affected and the majority reported local injection site reactions. Four individuals were hospitalized (all recovered) after receiving the wrong products. Several patients were inappropriately started on tuberculosis prophylaxis as a result of a vaccine local reaction being interpreted as a positive tuberculin skin test. Reported potential contributory factors involved both system factors (e.g. similar packaging) and human errors (e.g. failure to read label before product administration). Conclusions: To prevent PPD-vaccine mix-ups, proper storage, handling and administration of vaccine and PPD products is necessary. JF - Drug Safety AU - Chang, S AU - Pool, V AU - O'Connell, K AU - Polder, JA AU - Iskander, J AU - Sweeney, C AU - Ball, R AU - Braun, M M AD - 1 Office of Biostatistics and Epidemiology, US Food and Drug Administration (FDA), Rockville, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 1027 EP - 1033 VL - 31 IS - 11 SN - 0114-5916, 0114-5916 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Health & Safety Science Abstracts KW - vaccines KW - Mycobacterium KW - Children KW - Skin tests KW - tuberculosis KW - Storage KW - USA KW - Reviews KW - Prophylaxis KW - Proteins KW - Tuberculin KW - Tuberculosis KW - Human factors KW - Vaccines KW - Drugs KW - Side effects KW - Packaging KW - X 24310:Pharmaceuticals KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19634720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Safety&rft.atitle=Preventable+Mix-ups+of+Tuberculin+and+Vaccines%3A+Reports+to+the+US+Vaccine+and+Drug+Safety+Reporting+Systems&rft.au=Chang%2C+S%3BPool%2C+V%3BO%27Connell%2C+K%3BPolder%2C+JA%3BIskander%2C+J%3BSweeney%2C+C%3BBall%2C+R%3BBraun%2C+M+M&rft.aulast=Chang&rft.aufirst=S&rft.date=2008-01-01&rft.volume=31&rft.issue=11&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Drug+Safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Prophylaxis; Tuberculosis; Tuberculin; Vaccines; Children; Drugs; Side effects; Skin tests; Storage; tuberculosis; vaccines; Reviews; Proteins; Human factors; Packaging; Mycobacterium; USA ER - TY - JOUR T1 - Tracking the prevalence of rollover protective structures on U.S. farm tractors: 1993, 2001, and 2004 AN - 19626810; 8770130 AB - Problem - Between 1992 and 2005, 1412 workers on farms died from tractor overturns. A Rollover Protective Structure (ROPS) is a proven intervention to reduce overturn deaths. However, farm characteristics that are associated with the adoption of ROPS are not well understood. Methods - ROPS prevalence statistics were derived from National Institute for Occupational Safety and Health (NIOSH) surveys that tracked ROPS use on farms. Data were from the years 1993, 2001, and 2004. Results - In 1993, 38% of tractors were equipped with ROPS. This increased to 51% by 2004. ROPS prevalence rates were higher on farms in the Southern region of the United States, on farms where the operator was 25-34 years old, and on farms with $100,000 or more of farm sales. Low ROPS prevalence rates were associated with farm operators 65 years old or older and with farms with less than $10,000 of farm product sales. Summary - The increase in ROPS prevalence between 1993 and 2004 has not been sufficient to decrease the rate of tractor overturn deaths on farms. Incentive programs targeting older farm operators and low-income farm operations are suggested to increase ROPS use on tractors. Impact on Industry - The study provides farm characteristics associated with low ROPS prevalence rates. The results can be used to target farms for future ROPS promotion activities. JF - Journal of Safety Research AU - Loringer, Kelly A AU - Myers, John R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA, JrMyers@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 509 EP - 517 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 5 SN - 0022-4375, 0022-4375 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Socioeconomics KW - intervention KW - farms KW - rollover KW - Mortality KW - USA KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19626810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Tracking+the+prevalence+of+rollover+protective+structures+on+U.S.+farm+tractors%3A+1993%2C+2001%2C+and+2004&rft.au=Loringer%2C+Kelly+A%3BMyers%2C+John+R&rft.aulast=Loringer&rft.aufirst=Kelly&rft.date=2008-01-01&rft.volume=39&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; farms; Mortality; rollover; Socioeconomics; Occupational safety; intervention DO - http://dx.doi.org/10.1016/j.jsr.2008.08.003 ER - TY - JOUR T1 - Childhood overweight and obesity: is the gap closing the wrong way? AN - 19602419; 8201788 AB - BACKGROUND: Obesity is a significant public health issue. Obese children have an increased risk of developing chronic adult diseases. Knowledge of socio-economic distribution trends in childhood overweight/obesity is limited. METHODS: Body mass indices for 3-year-old children resident in three South Wales localities from 1995 to 2005 were derived from the National Community Child Health Database (NCCHD) and examined in relation to residence lower super output area (LSOA) Townsend Material Deprivation Score. RESULTS: Over 11 years, 53-69% of children had height/weight measurements recorded (with little difference observed across deprivation fifths). Amalgamating the data for all 11 years showed no significant association of prevalence with LSOA socio-economic status. Annual trends varied substantially: the most deprived fifth had the lowest proportion on five, and the highest on six, occasions. Linear regression analysis suggested a greater rate of increase of overweight/obesity in children from most-deprived LSOA areas compared with those from least deprived areas (not statistically significant). CONCLUSIONS: Socio-economic difference in overweight/obesity prevalence lessened between 1995 and 2005. Despite annual variation, this apparent closing of the gap has been the result of an increase in overweight/obesity prevalence in children from the most deprived areas who, initially, had a lower prevalence compared with children from least deprived areas, but by 2005, had overtaken them. JF - Journal of Public Health Medicine AU - Brunt, H AU - Lester, N AU - Davies, G AU - Williams, R AD - National Public Health Service for Wales, St. David's Park, Job's Well Road, Carmarthen SA31 3WY, UK Y1 - 2008 PY - 2008 DA - 2008 SP - 145 EP - 152 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 30 IS - 2 SN - 0957-4832, 0957-4832 KW - Risk Abstracts; Health & Safety Science Abstracts KW - obesity KW - Socioeconomics KW - Public health KW - body mass KW - British Isles, Wales, South Wales KW - annual variations KW - Children KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Medicine&rft.atitle=Childhood+overweight+and+obesity%3A+is+the+gap+closing+the+wrong+way%3F&rft.au=Brunt%2C+H%3BLester%2C+N%3BDavies%2C+G%3BWilliams%2C+R&rft.aulast=Brunt&rft.aufirst=H&rft.date=2008-01-01&rft.volume=30&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Medicine&rft.issn=09574832&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - British Isles, Wales, South Wales; obesity; Children; Socioeconomics; Public health; annual variations; body mass ER - TY - JOUR T1 - Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume AN - 19570198; 8819393 AB - Background Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 kg of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 kg soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure. Results BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found. Conclusion The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain. JF - Particle and Fibre Toxicology AU - Zeidler-Erdely, Patti C AU - Kashon, Michael L AU - Battelli, Lori A AU - Young, Shih-Houng AU - Erdely, Aaron AU - Roberts, Jenny R AU - Reynolds, Steven H AU - Antonini, James M AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA, paz9@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Pharynx KW - Fumes KW - Chromium KW - Heavy metals KW - Tumorigenesis KW - Tumorigenicity KW - Tumors KW - Alveoli KW - Inflammation KW - Bronchus KW - Lung KW - Welding KW - Steel KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19570198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Pulmonary+inflammation+and+tumor+induction+in+lung+tumor+susceptible+A%2FJ+and+resistant+C57BL%2F6J+mice+exposed+to+welding+fume&rft.au=Zeidler-Erdely%2C+Patti+C%3BKashon%2C+Michael+L%3BBattelli%2C+Lori+A%3BYoung%2C+Shih-Houng%3BErdely%2C+Aaron%3BRoberts%2C+Jenny+R%3BReynolds%2C+Steven+H%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-5-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fumes; Pharynx; Chromium; Heavy metals; Tumorigenesis; Tumorigenicity; Tumors; Alveoli; Inflammation; Bronchus; Lung; Welding; Steel DO - http://dx.doi.org/10.1186/1743-8977-5-12 ER - TY - JOUR T1 - Issues When Modeling Benzene, Toluene, and Xylene Exposures Using a Literature Database AN - 19539753; 8502026 AB - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource(s): a PDF file of QQ plots and a Word file with references used in the benzene/toluene/xylene exposure database.] JF - Journal of Occupational and Environmental Hygiene AU - Hein, Misty J AU - Waters, Martha A AU - van Wijngaarden, Edwin AU - Deddens, James A AU - Stewart, Patricia A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 36 EP - 47 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 1 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Historical account KW - Statistics KW - Ventilation KW - Toluene KW - Statistical analysis KW - Benzene KW - Models KW - Xylene KW - Occupational exposure KW - Environmental hygiene KW - Temperature effects KW - Data processing KW - Mathematical models KW - Temperature KW - community involvement KW - Databases KW - Reviews KW - Hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Issues+When+Modeling+Benzene%2C+Toluene%2C+and+Xylene+Exposures+Using+a+Literature+Database&rft.au=Hein%2C+Misty+J%3BWaters%2C+Martha+A%3Bvan+Wijngaarden%2C+Edwin%3BDeddens%2C+James+A%3BStewart%2C+Patricia+A&rft.aulast=Hein&rft.aufirst=Misty&rft.date=2008-01-01&rft.volume=5&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701763947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Mathematical models; Data processing; Statistics; Ventilation; Toluene; Statistical analysis; Benzene; Models; Databases; Xylene; Reviews; Occupational exposure; Environmental hygiene; Historical account; Temperature; Hygiene; community involvement DO - http://dx.doi.org/10.1080/15459620701763947 ER - TY - JOUR T1 - Antimicrobial Resistance Genes Associated with Salmonella enterica Serovar Newport Isolates from Food Animals AN - 19526802; 7932106 AB - Salmonella enterica serotype Newport is an important cause of salmonellosis, with strains increasingly being resistant to multiple antimicrobial agents. The increase is associated with the acquisition of multiple resistance genes. This study characterizes the genetic basis of resistance of serotype Newport isolates collected from veterinary sources by PCR and DNA sequencing analysis. JF - Antimicrobial Agents & Chemotherapy AU - Lynne, Aaron M AU - Rhodes-Clark, Bobbie S AU - Bliven, Kimberly AU - Zhao, Shaohua AU - Foley, Steven L AD - National Farm Medicine Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449. Department of Biology, University of Central Arkansas, Conway, Arkansas 72035. Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 353 EP - 356 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA sequencing KW - Serotypes KW - Salmonella enterica KW - Drug resistance KW - Food KW - Salmonellosis KW - Polymerase chain reaction KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19526802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antimicrobial+Resistance+Genes+Associated+with+Salmonella+enterica+Serovar+Newport+Isolates+from+Food+Animals&rft.au=Lynne%2C+Aaron+M%3BRhodes-Clark%2C+Bobbie+S%3BBliven%2C+Kimberly%3BZhao%2C+Shaohua%3BFoley%2C+Steven+L&rft.aulast=Lynne&rft.aufirst=Aaron&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA sequencing; Serotypes; Salmonellosis; Food; Drug resistance; Polymerase chain reaction; Antimicrobial agents; Salmonella enterica ER - TY - JOUR T1 - The suicide mortality of working physicians and dentists AN - 19522441; 7936933 AB - BACKGROUND: Some studies have shown that physicians and dentists have elevated risks of suicide, while other studies have not. Aims Using all deaths and corresponding census data in 26 US states, we examine the suicide risk for working physicians and dentists. METHODS: Death and census data for working people were obtained from 1984 through 1992. Directly age-standardized suicide rate ratios (SRRs) were calculated for white male and white female physicians and white male dentists. RESULTS: For white female physicians, the suicide rate was elevated compared to the working US population (SRR = 2.39, 95% CI = 1.52-3.77). For white male physicians and dentists, the overall suicide rates were reduced (SRR = 0.80, 95% CI = 0.53-1.20 and 0.68, 95% CI = 0.52-0.89, respectively). For older white male physicians and dentists, however, observed suicide rates were elevated. CONCLUSIONS: White female physicians have an elevated suicide rate. Only older white male physicians and dentists have elevated suicide rates, which partially explains the varied conclusions in the literature. JF - Occupational Medicine AU - Petersen, Martin R AU - Burnett, Carol A AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 25 EP - 29 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 1 SN - 0962-7480, 0962-7480 KW - Risk Abstracts; Health & Safety Science Abstracts KW - census KW - Mortality KW - suicide KW - Working conditions KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Medicine&rft.atitle=The+suicide+mortality+of+working+physicians+and+dentists&rft.au=Petersen%2C+Martin+R%3BBurnett%2C+Carol+A&rft.aulast=Petersen&rft.aufirst=Martin&rft.date=2008-01-01&rft.volume=58&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Occupational+Medicine&rft.issn=09627480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - census; Mortality; Working conditions; suicide; Occupational health ER - TY - JOUR T1 - In Vitro Evaluation of the Protective Role of Human Antibodies to West Nile Virus (WNV) Produced during Natural WNV Infection AN - 19488016; 8585599 AB - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious. Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs). Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody- positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious. Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation. JF - Journal of Infectious Diseases AU - Rios, M AU - Daniel, S AU - Dayton, AI AU - Wood, O AU - Hewlett, I K AU - Epstein, J S AU - Caglioti, S AU - Stramer, S L AD - Laboratory of Molecular Virology-Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, and American Red Cross, Gaithersburg, Maryland, Maria.Rios@fda.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1300 EP - 1308 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu] VL - 198 IS - 9 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts; Virology & AIDS Abstracts KW - Macrophages KW - Human diseases KW - Vero cells KW - Cell culture KW - Infection KW - Transfusion KW - Disease transmission KW - Public health KW - Blood KW - USA KW - Infectivity KW - Antibodies KW - Endemic species KW - RNA KW - Viral diseases KW - Infectious diseases KW - Viremia KW - Monocytes KW - West Nile virus KW - V 22350:Immunology KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19488016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=In+Vitro+Evaluation+of+the+Protective+Role+of+Human+Antibodies+to+West+Nile+Virus+%28WNV%29+Produced+during+Natural+WNV+Infection&rft.au=Rios%2C+M%3BDaniel%2C+S%3BDayton%2C+AI%3BWood%2C+O%3BHewlett%2C+I+K%3BEpstein%2C+J+S%3BCaglioti%2C+S%3BStramer%2C+S+L&rft.aulast=Rios&rft.aufirst=M&rft.date=2008-01-01&rft.volume=198&rft.issue=9&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F592277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Endemic species; Human diseases; Antibodies; Infectious diseases; Viral diseases; Public health; Disease transmission; Blood; Infectivity; RNA; Vero cells; Cell culture; Monocytes; Viremia; Transfusion; Infection; West Nile virus; USA DO - http://dx.doi.org/10.1086/592277 ER - TY - JOUR T1 - Compact and portable digitally controlled device for testing footwear materials: Technical note AN - 19425756; 8833338 AB - Little or no practical decision-making data are available to the foot-care provider regarding the selection of orthotic materials used in therapeutic footwear. A device for simulating in-shoe forefoot conditions for the testing of ortho-sis materials is described. Materials are tested for their effectiveness by evaluating and comparing stress-strain and dynamic compression fatigue characteristics. The device, called the Cyclical Compression Tester (CCT), has been optimized for size, simplicity of construction, and cost. Application of the device ranges from the clinician deciding the useful life of single- and multidensity orthosis materials to the researcher characterizing materials for finite-element analysis modeling. This real-time CCT device and custom user interface combine to make an evaluation tool useful for testing how the pressure distribution of in-shoe materials changes over time in therapeutic footwear for those with peripheral neuropathy at risk for foot injury. JF - Journal of Rehabilitation Research and Development AU - Foto, J G AD - National Hansen's Disease Programs, Paul W. Brand Biomechanics Laboratory, 1770 Physicians Park Dr, Baton Rouge, LA 70816, USA, jfoto@hrsa.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 893 EP - 900 VL - 45 IS - 6 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Evaluation KW - Fatigue KW - Feet KW - Injuries KW - Analysis KW - Stress KW - Orthotics KW - Shoes KW - Modeling KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Compact+and+portable+digitally+controlled+device+for+testing+footwear+materials%3A+Technical+note&rft.au=Foto%2C+J+G&rft.aulast=Foto&rft.aufirst=J&rft.date=2008-01-01&rft.volume=45&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.07.0111 LA - English DB - Physical Education Index N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Shoes; Orthotics; Modeling; Analysis; Evaluation; Feet; Fatigue; Stress; Injuries DO - http://dx.doi.org/10.1682/JRRD.2007.07.0111 ER - TY - JOUR T1 - A new approach to characterize grip force applied to a cylindrical handle AN - 19419940; 8808321 AB - The grip force applied to a cylindrical handle is a function of the measurement reference axis. So far, however, no attempt has been made to fully describe the exact form of this function. The objectives of this study were to examine some fundamental characteristics of grip forces and to explore the basic pattern of the grip force function. Twenty subjects (10 males and 10 females) participated in the experiment. The subjects alternately used their left and right hands to apply maximum grip forces and medium grip forces (about 40% of maximum) to a 30 mm handle. A flexible pressure sensor mat was used to measure the grip pressure. The pressure was integrated with respect to different measurement axes; this resulted in the grip force function. This study found that every gripping action produces maximum and minimum force axes; these axes are separated by about 90 degree . The maximum force is correlated with the minimum force, but the former is generally about 1.42 times the latter. The principal grip direction is about 78 degree from the z sub(h)-axis of the hand biodynamic coordinate system defined in ISO 8727 [ISO 8727. Mechanical vibration and shock - human exposure - biodynamic coordinate systems. Geneva, Switzerland: International Organization for Standardization; 1997]. More interestingly, each of the 160 sets of experimental data reasonably fit this study's proposed elliptical model. The implications of the findings are discussed. JF - Medical Engineering & Physics AU - Dong, Ren G AU - Wu, John Z AU - Welcome, Daniel E AU - McDowell, Thomas W AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA, rkd6@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 20 EP - 33 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 1 SN - 1350-4533, 1350-4533 KW - Biotechnology and Bioengineering Abstracts KW - Vibrations KW - Standardization KW - Mathematical models KW - Data processing KW - Shock KW - Grasping KW - International organizations KW - Hand KW - Pressure KW - Models KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19419940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Engineering+%26+Physics&rft.atitle=A+new+approach+to+characterize+grip+force+applied+to+a+cylindrical+handle&rft.au=Dong%2C+Ren+G%3BWu%2C+John+Z%3BWelcome%2C+Daniel+E%3BMcDowell%2C+Thomas+W&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2008-01-01&rft.volume=30&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Medical+Engineering+%26+Physics&rft.issn=13504533&rft_id=info:doi/10.1016%2Fj.medengphy.2007.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Grasping; Pressure; Hand; Vibrations; International organizations; Data processing; Models; Mathematical models; Shock; Standardization DO - http://dx.doi.org/10.1016/j.medengphy.2007.01.002 ER - TY - JOUR T1 - Reduction of Fumonisin B sub(1) in Corn Grits by Single-Screw Extrusion AN - 19298428; 8133999 AB - This study was designed to determine the efficacy of extrusion in reducing fumonisin B sub(1) in corn flaking grits in the presence and absence of glucose. In addition, degradation products of fumonisin B sub(1) during extrusion were identified and quantitated with a mass balance approach. Uncontaminated clean corn grits, grits spiked with 30 kg/g fumonisin B sub(1), and grits fermented with Fusarium verticillioides M-2552 (40-50 kg/g fumonisin B sub(1)) were extruded in the presence and absence of glucose (10%, w/w) using a single-screw extruder. Extrusion decreased fumonisin B sub(1) by 21-37%, whereas the same process with added glucose further decreased fumonisin B sub(1) by 77-87%. LC-fluorescence and LC-MS showed that most fumonisin in the extruded samples without added glucose was the fumonisin B sub(1) form, whereas the main degradation product in grits extruded with glucose was N-(deoxy-D-fructos-1-yl)fumonisin B sub(1). The formation of hydrolyzed fumonisin B sub(1) was not significant during extrusion. Results suggest that extrusion in the presence of glucose may reduce fumonisin B sub(1) in corn grits significantly. KW: Fumonisin; reduction; N-(deoxy-D- fructos-1-yl)fumonisin; extrusion. JF - Journal of Agricultural and Food Chemistry AU - Jablonski, Joseph AU - Jackson, Lauren S AU - Ryu, Dojin AU - Hanna, Milford A AU - Bianchini, Andreia AU - Bullerman, Lloyd B AD - Department of Food Science and Technology, 143 Filley Hall, University of Nebraska, Lincoln, Nebraska 68583; National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois 60501; and Department of Nutrition and Food Sciences, Texas Woman's University, P.O. Box 425888, Denton, Texas 76204 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 2400 EP - 2405 PB - American Chemical Society, [mailto:service@acs.org] VL - 56 IS - 7 SN - 0021-8561, 0021-8561 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Glucose KW - Fumonisin B1 KW - Fusarium verticillioides KW - Degradation products KW - A 01330:Food Microbiology KW - W 30935:Food Biotechnology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Reduction+of+Fumonisin+B+sub%281%29+in+Corn+Grits+by+Single-Screw+Extrusion&rft.au=Jablonski%2C+Joseph%3BJackson%2C+Lauren+S%3BRyu%2C+Dojin%3BHanna%2C+Milford+A%3BBianchini%2C+Andreia%3BBullerman%2C+Lloyd+B&rft.aulast=Jablonski&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=56&rft.issue=7&rft.spage=2400&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf0729513 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Glucose; Fumonisin B1; Degradation products; Fusarium verticillioides DO - http://dx.doi.org/10.1021/jf0729513 ER - TY - JOUR T1 - Mesenchymal stem cells in arthritic diseases AN - 19290076; 8746636 AB - Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis (OA) is the most common arthritic condition and, like rheumatoid arthritis (RA), presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition, through secretion of various soluble factors, MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of stem cell biology as relevant to diseases of the joint. The potential involvement of MSCs in the pathophysiology of degenerative joint diseases will also be discussed. Specifically, we will explore the potential of MSC-based cell therapy of OA and RA by means of functional replacement of damaged cartilage via tissue engineering as well as their anti-inflammatory and immunosuppressive activities. JF - Arthritis Research & Therapy AU - Chen, F H AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Building 50, 50 South Dr., Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 223 VL - 10 IS - 5 SN - 1478-6354, 1478-6354 KW - Biotechnology and Bioengineering Abstracts KW - Cartilage diseases KW - Osteoarthritis KW - Joint diseases KW - Therapeutic applications KW - Cell culture KW - Inflammation KW - Differentiation KW - Rheumatoid arthritis KW - Stem cells KW - Reviews KW - Mesenchyme KW - Immunosuppression KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19290076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Mesenchymal+stem+cells+in+arthritic+diseases&rft.au=Chen%2C+F+H%3BTuan%2C+R+S&rft.aulast=Chen&rft.aufirst=F&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stem cells; Osteoarthritis; Joint diseases; Inflammation; Mesenchyme; Cartilage diseases; Reviews; Differentiation; Cell culture; Therapeutic applications; Immunosuppression; Rheumatoid arthritis DO - http://dx.doi.org/10.1186/ar2514 ER - TY - JOUR T1 - Diagnosing and controlling moisture-sensitive roof in coal mines AN - 1560085620; 2014-066486 AB - Historically, coal miners have known that roof shales can deteriorate in contact with humid mine air, causing massive roof falls and injuries from falling rock. It is critical to recognize rocks prone to weathering and to adequately support these rocks in order to ensure the long-term stability of the openings. In a recent study, NIOSH has used a wet/dry cycling test to determine the moisture sensitivity of over 800 specimens of roof rock from 25 U.S. coal mines. Fireclays and some gray shales are the most moisture-sensitive. Rocks with disturbed bedding, in contrast to flat-bedded rocks, are also more sensitive to water. Black shales are relatively un-reactive to moisture and serve to protect more reactive gray shales above. Mines that have roof rocks with moisture-sensitivity indexes above 40% can experience slaking roof conditions, and many require high coverage surface controls. Three case studies are presented in which the moisture-sensitivity index is correlated to roof conditions underground, and can be used to indicate long term deterioration. Engineering measures are described to control moisture-sensitive roof. In one case, roof screen not only reduces injuries from rock fall but also is shown to reduce roof falls. JF - The Electronic Journal of Geotechnical Engineering AU - Molinda, Greg AU - Klemetti, Ted Y1 - 2008 PY - 2008 DA - 2008 SP - 20 PB - Mete Oner, Stillwater, OK VL - 13 IS - Bundle A KW - United States KW - mines KW - shale KW - roof control KW - moisture KW - coal mines KW - stability KW - weathering KW - rock mechanics KW - case studies KW - black shale KW - sedimentary rocks KW - mining geology KW - clastic rocks KW - fireclay KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560085620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Electronic+Journal+of+Geotechnical+Engineering&rft.atitle=Diagnosing+and+controlling+moisture-sensitive+roof+in+coal+mines&rft.au=Molinda%2C+Greg%3BKlemetti%2C+Ted&rft.aulast=Molinda&rft.aufirst=Greg&rft.date=2008-01-01&rft.volume=13&rft.issue=Bundle+A&rft.spage=&rft.isbn=&rft.btitle=&rft.title=The+Electronic+Journal+of+Geotechnical+Engineering&rft.issn=1089-3032&rft_id=info:doi/ L2 - http://www.ejge.com/Index_ejge.htm LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. N1 - Date revised - 2014-01-01 N1 - Number of references - 21 N1 - PubXState - OK N1 - Document feature - illus. incl. 2 tables, sketch maps N1 - Last updated - 2017-01-19 N1 - SubjectsTermNotLitGenreText - black shale; case studies; clastic rocks; coal mines; fireclay; mines; mining geology; moisture; rock mechanics; roof control; sedimentary rocks; shale; stability; United States; weathering ER - TY - JOUR T1 - Over-the-counter vaginal contraceptive and spermicide drug products containing nonoxynol 9; required labeling. Final rule. AN - 69082878; 18159651 AB - The Food and Drug Administration (FDA) is issuing a final rule establishing new warning statements and other labeling information for all over-the-counter (OTC) vaginal contraceptive drug products (also known as spermicides, hereinafter referred to as vaginal contraceptives or vaginal contraceptives/spermicides) containing nonoxynol 9 (N9). These warning statements will advise consumers that vaginal contraceptives/spermicides containing N9 do not protect against infection from the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), or against getting other sexually transmitted diseases (STDs). The warnings and labeling information will also advise consumers that use of vaginal contraceptives and spermicides containing N9 can irritate the vagina and rectum and may increase the risk of getting the AIDS virus (HIV) from an infected partner. This final rule is part of FDA's ongoing review of OTC drug products. FDA is issuing this final rule after considering public comments on its proposed regulation, and all relevant data and information on N9 that have come to our attention. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2007/12/19/ PY - 2007 DA - 2007 Dec 19 SP - 71769 EP - 71785 VL - 72 IS - 243 SN - 0097-6326, 0097-6326 KW - Contraceptive Agents KW - 0 KW - Nonprescription Drugs KW - Spermatocidal Agents KW - Nonoxynol KW - 26027-38-3 KW - Health technology assessment KW - United States KW - Condoms KW - Nonprescription Drugs -- adverse effects KW - HIV Infections -- transmission KW - Nonprescription Drugs -- therapeutic use KW - Humans KW - HIV Infections -- prevention & control KW - Nonprescription Drugs -- administration & dosage KW - Sexually Transmitted Diseases -- prevention & control KW - Sexually Transmitted Diseases -- transmission KW - Male KW - Female KW - Contraceptive Agents -- therapeutic use KW - Spermatocidal Agents -- adverse effects KW - Nonoxynol -- administration & dosage KW - Contraceptive Agents -- administration & dosage KW - Nonoxynol -- therapeutic use KW - Spermatocidal Agents -- administration & dosage KW - Nonoxynol -- adverse effects KW - Drug Labeling -- legislation & jurisprudence KW - Spermatocidal Agents -- therapeutic use KW - Contraceptive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69082878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Over-the-counter+vaginal+contraceptive+and+spermicide+drug+products+containing+nonoxynol+9%3B+required+labeling.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-12-19&rft.volume=72&rft.issue=243&rft.spage=71769&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic changes in the rat livers induced by pyrazinamide treatment AN - 20841297; 7939496 AB - Drug-induced liver injury, including drug-induced hepatotoxicity during the treatment of tuberculosis infection, is a major health problem with increasingly significant challenges to modern hepatology. Therefore, the assessment and monitoring of the hepatotoxicity of antituberculosis drugs for prevention of liver injury are great concerns during disease treatment. The recently emerged data showing the ability of toxicants, including pharmaceutical agents, to alter cellular epigenetic status, open a unique opportunity for early detection of drug hepatotoxicity. Here we report that treatment of male Wistar rats with antituberculosis drug pyrazinamide at doses of 250, 500 or 1000 mg/kg/day body weight for 45 days leads to an early and sustained decrease in cytosine DNA methylation, progressive hypomethylation of long interspersed nucleotide elements (LINE-1), and aberrant promoter hypermethylation of placental form glutathione-S-transferase (GSTP) and p16 super(I) super(N) super(K) super(4) super(A) genes in livers of pyrazinamide-treated rats, while serum levels of bilirubin and activity of aminotransferases changed modestly. The early occurrence of these epigenetic alterations and their association with progression of liver injury specific pathological changes indicate that alterations in DNA methylation may be useful predictive markers for the assessment of drug hepatotoxicity. JF - Toxicology and Applied Pharmacology AU - Kovalenko, V M AU - Bagnyukova, T V AU - Sergienko, O V AU - Bondarenko, L B AU - Shayakhmetova, G M AU - Matvienko, A V AU - Pogribny, I P AD - Jefferson, AR, USA, igor.pogribny@fda.hhs.gov Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 293 EP - 299 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 225 IS - 3 SN - 0041-008X, 0041-008X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - Toxicants KW - Injuries KW - Mycobacterium KW - Glutathione transferase KW - Infection KW - Drug screening KW - Promoters KW - Cytosine KW - p16 protein KW - Body weight KW - epigenetics KW - Placenta KW - DNA methylation KW - Long interspersed nucleotide elements KW - Tuberculosis KW - Bilirubin KW - Drugs KW - Data processing KW - INK4a protein KW - hepatotoxicity KW - Serum levels KW - Liver KW - Pharmaceuticals KW - pyrazinamide KW - J 02310:Genetics & Taxonomy KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20841297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Epigenetic+changes+in+the+rat+livers+induced+by+pyrazinamide+treatment&rft.au=Kovalenko%2C+V+M%3BBagnyukova%2C+T+V%3BSergienko%2C+O+V%3BBondarenko%2C+L+B%3BShayakhmetova%2C+G+M%3BMatvienko%2C+A+V%3BPogribny%2C+I+P&rft.aulast=Kovalenko&rft.aufirst=V&rft.date=2007-12-15&rft.volume=225&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Toxicants; INK4a protein; Drug screening; Infection; Glutathione transferase; hepatotoxicity; Serum levels; Cytosine; Promoters; p16 protein; Body weight; epigenetics; Placenta; Liver; DNA methylation; Pharmaceuticals; Long interspersed nucleotide elements; Bilirubin; Tuberculosis; pyrazinamide; Drugs; Mycobacterium DO - http://dx.doi.org/10.1016/j.taap.2007.08.011 ER - TY - JOUR T1 - Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. AN - 69056043; 18074021 AB - DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication. Five human DNA helicases sharing sequence similarity with the E. coli RecQ helicase have been identified. Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer. RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known. In this study, we report that RECQ1 becomes phosphorylated upon DNA damage and forms irradiation-induced nuclear foci that associate with chromatin in human cells. Depletion of RECQ1 renders human cells sensitive to DNA damage induced by ionizing radiation or the topoisomerase inhibitor camptothecin, and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks. Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity. Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis. JF - PloS one AU - Sharma, Sudha AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Y1 - 2007/12/12/ PY - 2007 DA - 2007 Dec 12 SP - 1 VL - 2 IS - 12 KW - Mutagens KW - 0 KW - RNA, Small Interfering KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Base Sequence KW - HeLa Cells KW - Humans KW - Sister Chromatid Exchange KW - DNA Damage KW - RecQ Helicases -- metabolism KW - Oxidative Stress KW - RecQ Helicases -- genetics KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Human+RECQ1+is+a+DNA+damage+responsive+protein+required+for+genotoxic+stress+resistance+and+suppression+of+sister+chromatid+exchanges.&rft.au=Sharma%2C+Sudha%3BBrosh%2C+Robert+M&rft.aulast=Sharma&rft.aufirst=Sudha&rft.date=2007-12-12&rft.volume=2&rft.issue=12&rft.spage=e1297&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nucleic Acids Res. 2004;32(7):2158-70 [15096578] Mol Cell Biol. 2001 Jan;21(1):281-8 [11113202] J Cell Biol. 2001 Apr 16;153(2):367-80 [11309417] J Biol Chem. 2001 Jun 1;276(22):19375-81 [11278509] Mutat Res. 2002 Nov 30;509(1-2):49-78 [12427531] Mol Biol Cell. 2002 Nov;13(11):4100-9 [12429849] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] J Biol Chem. 2003 Jan 17;278(3):1424-32 [12419808] Curr Genet. 2003 Jan;42(4):220-7 [12589473] Science. 1999 Dec 17;286(5448):2342-4 [10600745] Carcinogenesis. 2000 Mar;21(3):485-95 [10688869] Cancer Res. 2000 Mar 1;60(5):1162-7 [10728666] Hum Mol Genet. 2000 Jul 22;9(12):1805-11 [10915769] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Mol Cell Biol. 2003 May;23(10):3692-705 [12724426] Nature. 2003 May 15;423(6937):305-9 [12748644] Nature. 2003 May 15;423(6937):309-12 [12748645] Genes Dev. 2003 Aug 15;17(16):2021-35 [12893777] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972] Curr Genet. 2004 Feb;45(1):37-44 [14595518] Cancer Res. 2004 Mar 1;64(5):1834-42 [14996747] J Cell Biol. 2004 Sep 13;166(6):801-13 [15364958] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Cancer Genet Cytogenet. 1993 Oct 15;70(2):85-93 [8242603] J Biol Chem. 1994 Nov 25;269(47):29838-45 [7961977] Nucleic Acids Res. 1994 Nov 11;22(22):4566-73 [7527136] Genomics. 1995 Apr 10;26(3):595-8 [7607686] Cell. 1997 Feb 7;88(3):323-31 [9039259] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6887-92 [9618508] Exp Cell Res. 1998 Aug 1;242(2):487-94 [9683536] Nature. 2005 Jan 6;433(7021):77-83 [15635413] Blood. 2005 Feb 1;105(3):1003-9 [15454491] Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55 [15688066] Genetics. 2005 Feb;169(2):563-74 [15489516] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Cancer Cell. 2005 Jun;7(6):505-12 [15950900] EMBO J. 2005 Jul 20;24(14):2679-87 [15990871] J Biol Chem. 2005 Jul 29;280(30):28085-94 [15886194] J Biol Chem. 2005 Jul 29;280(30):28072-84 [15899892] J Cell Sci. 2005 Sep 15;118(Pt 18):4261-9 [16141230] Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871] Nucleic Acids Res. 2005;33(19):6251-7 [16260474] Genetics. 2006 Jan;172(1):113-25 [16219790] Cancer Res. 2006 Mar 15;66(6):3323-30 [16540687] J Clin Oncol. 2006 Apr 10;24(11):1720-8 [16520463] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5875-80 [16595622] Science. 2006 Jul 21;313(5785):363-7 [16778019] Biochem J. 2006 Sep 15;398(3):319-37 [16925525] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Mol Cell Biol. 2007 Mar;27(5):1784-94 [17158923] PLoS Biol. 2007 Feb;5(2):e20 [17227144] J Cell Sci. 2007 Mar 1;120(Pt 5):713-21 [17314245] Bioessays. 2007 Apr;29(4):382-5 [17373697] Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497] Oncogene. 2000 Sep 28;19(41):4764-72 [11032027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles AN - 20474742; 7941689 AB - In order to evaluate the pulmonary effects and inflammatory mechanisms of ultrafine amorphous silica particles (UFASs), the UFASs suspension was prepared in PBS and intratracheally administered to A/J mice at doses of 0, 2, 10 and 50mg/kg (n=5 per group). Animals were sacrificed at 24h, and 1, 4 or 14 weeks following exposures. At each time point, a bronchoalveolar lavage fluid analysis, histopathological examination, quantitative real-time PCR and immunohistochemistry of the lung tissues were assessed. The intratracheal instillation of UFASs significantly increased the lung weights and total BAL cells following exposures. The histopathological examination revealed that UFASs-induced severe inflammation, with neutrophils, at an early stage and chronic granulomatous inflammation at the later stage. The mRNA and protein levels of IL-1 beta , IL-6, IL-8, TNF- alpha , MCP-1 and MIP-2 in lung tissues were significantly increased during the early stages, but there were no changes after weeks 1 (TNF- alpha ) or 4 (IL-1 beta , IL-6, IL-8, MCP-1 and MIP-2). Instillation of UFASs-induced transient, but very severe lung inflammation. Therefore, the cytokines (IL-1 beta , IL-6, IL-8 and TNF- alpha ) and chemokines (MCP-1 and MIP-2) play important roles in the inflammation induced by the intratracheal instillation of UFASs. JF - Toxicology Letters AU - Cho, W S AU - Choi, M AU - Han, B S AU - Cho, M AU - Oh, J AU - Park, K AU - Kim, S J AU - Kim, SH AU - Jeong, J AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea, jjy_kfda@kfda.go.kr Y1 - 2007/12/10/ PY - 2007 DA - 2007 Dec 10 SP - 24 EP - 33 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 175 IS - 1-3 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Interleukin 6 KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Interleukin 1 KW - Leukocytes (neutrophilic) KW - Interleukin 8 KW - Alveoli KW - mRNA KW - Inflammation KW - Silica KW - Bronchus KW - Lung KW - Polymerase chain reaction KW - Tumor necrosis factor- alpha KW - Immunohistochemistry KW - Trachea KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20474742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Inflammatory+mediators+induced+by+intratracheal+instillation+of+ultrafine+amorphous+silica+particles&rft.au=Cho%2C+W+S%3BChoi%2C+M%3BHan%2C+B+S%3BCho%2C+M%3BOh%2C+J%3BPark%2C+K%3BKim%2C+S+J%3BKim%2C+SH%3BJeong%2C+J&rft.aulast=Cho&rft.aufirst=W&rft.date=2007-12-10&rft.volume=175&rft.issue=1-3&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2007.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Chemokines; Monocyte chemoattractant protein 1; Interleukin 1; Leukocytes (neutrophilic); Alveoli; Interleukin 8; Inflammation; mRNA; Silica; Bronchus; Lung; Polymerase chain reaction; Tumor necrosis factor- alpha; Trachea; Immunohistochemistry DO - http://dx.doi.org/10.1016/j.toxlet.2007.09.008 ER - TY - CPAPER T1 - S-ethyl-N,N-dipropylthiocarbamate (EPTC) Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study, a Prospective Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40809096; 4802173 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Van Bemmel, D M AU - Visvanathan, K AU - Freeman, L. E. Beane AU - Coble, J B AU - Hoppin, J A AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=S-ethyl-N%2CN-dipropylthiocarbamate+%28EPTC%29+Exposure+and+Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study%2C+a+Prospective+Cohort.&rft.au=Van+Bemmel%2C+D+M%3BVisvanathan%2C+K%3BFreeman%2C+L.+E.+Beane%3BCoble%2C+J+B%3BHoppin%2C+J+A%3BAlavanja%2C+M.+C.R.&rft.aulast=Van+Bemmel&rft.aufirst=D&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evidence for the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. AN - 69031116; 18056663 AB - High blood pressure is common, and screening is a well-established evidence-based standard of current medical practice. To perform a literature search for new, substantial evidence on screening for high blood pressure that would inform the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. The PubMed and Cochrane databases were searched. The searches were limited to English-language articles on studies of adult humans (age >18 years) that were published between 1 October 2001 and 31 March 2006 in core clinical journals. For the literature on benefits, meta-analyses; systematic reviews; and randomized, controlled trials were included. For harms, meta-analyses; systematic reviews; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases were included. Two reviewers independently reviewed titles, abstracts, and full articles for inclusion. No new evidence was found on benefits or harms of screening. Two reviewers extracted data from studies on the harms of early treatment, including adverse effects of drug therapy and adverse quality-of-life outcomes. No new evidence was found for the benefits of screening for high blood pressure. New evidence on the harms of treatment of early hypertension shows that pharmacologic therapy is associated with common side effects; serious adverse events are uncommon. The nonsystematic search may have missed some smaller studies on the benefits and harms of screening and treatment for high blood pressure. No new evidence was found on the benefits of screening. Pharmacotherapy for early hypertension is associated with common side effects. JF - Annals of internal medicine AU - Wolff, Tracy AU - Miller, Therese AD - .S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Y1 - 2007/12/04/ PY - 2007 DA - 2007 Dec 04 SP - 787 EP - 791 VL - 147 IS - 11 KW - Antihypertensive Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Cardiovascular Diseases -- etiology KW - Risk Factors KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Adult KW - Time Factors KW - Male KW - Female KW - Cardiovascular Diseases -- prevention & control KW - Hypertension -- complications KW - Hypertension -- diagnosis KW - Mass Screening -- adverse effects KW - Hypertension -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69031116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Evidence+for+the+reaffirmation+of+the+U.S.+Preventive+Services+Task+Force+recommendation+on+screening+for+high+blood+pressure.&rft.au=Wolff%2C+Tracy%3BMiller%2C+Therese&rft.aulast=Wolff&rft.aufirst=Tracy&rft.date=2007-12-04&rft.volume=147&rft.issue=11&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-10 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Summary For Patients In: Ann Intern Med. 2007 Dec 4;147(11):I43 [18056657] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Impact of Underage Drinking and the Risk of HIV Among African Americans T2 - 2007 National HIV Prevention Conference AN - 39716091; 4737329 JF - 2007 National HIV Prevention Conference AU - Richards, C AU - Cooke, V C AU - Schaffer, T M Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Africa KW - Human immunodeficiency virus KW - Ethnic groups KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39716091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Impact+of+Underage+Drinking+and+the+Risk+of+HIV+Among+African+Americans&rft.au=Richards%2C+C%3BCooke%2C+V+C%3BSchaffer%2C+T+M&rft.aulast=Richards&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Training and Implementation for Protocol-Based Counseling (PBC) in Houston: An Evidence-Based CTR Intervention T2 - 2007 National HIV Prevention Conference AN - 39653523; 4737185 JF - 2007 National HIV Prevention Conference AU - Agee, G B AU - Wiley, C AU - Hall, H Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Training KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Training+and+Implementation+for+Protocol-Based+Counseling+%28PBC%29+in+Houston%3A+An+Evidence-Based+CTR+Intervention&rft.au=Agee%2C+G+B%3BWiley%2C+C%3BHall%2C+H&rft.aulast=Agee&rft.aufirst=G&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Creating HIV/STD Prevention Standards to Improve Quality Management Activities: A Houston Perspective T2 - 2007 National HIV Prevention Conference AN - 39634796; 4737113 JF - 2007 National HIV Prevention Conference AU - Mitts, B J AU - Joseph-White, D AU - Kweekeh, F AU - Washington-Philip, E AU - Simpson, B AU - Prescott, L Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - Prevention KW - Sexually-transmitted diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Creating+HIV%2FSTD+Prevention+Standards+to+Improve+Quality+Management+Activities%3A+A+Houston+Perspective&rft.au=Mitts%2C+B+J%3BJoseph-White%2C+D%3BKweekeh%2C+F%3BWashington-Philip%2C+E%3BSimpson%2C+B%3BPrescott%2C+L&rft.aulast=Mitts&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prenatal HIV Screening: Ongoing Challenges and Lessons Learned T2 - 2007 National HIV Prevention Conference AN - 39634431; 4737045 JF - 2007 National HIV Prevention Conference AU - Reilley, B AU - Giberson, S AU - Cheek, J Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Prenatal+HIV+Screening%3A+Ongoing+Challenges+and+Lessons+Learned&rft.au=Reilley%2C+B%3BGiberson%2C+S%3BCheek%2C+J&rft.aulast=Reilley&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV/STD Planning and Implementation Through Community Groups T2 - 2007 National HIV Prevention Conference AN - 39628256; 4737121 JF - 2007 National HIV Prevention Conference AU - Hall, H H AU - Agee, G AU - Wiley, C AU - Cavazos, J Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Sexually-transmitted diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=HIV%2FSTD+Planning+and+Implementation+Through+Community+Groups&rft.au=Hall%2C+H+H%3BAgee%2C+G%3BWiley%2C+C%3BCavazos%2C+J&rft.aulast=Hall&rft.aufirst=H&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Surveillance Data to Evaluate Concurrent HIV and AIDS Diagnoses in Houston/Harris County, TX T2 - 2007 National HIV Prevention Conference AN - 39622029; 4737493 JF - 2007 National HIV Prevention Conference AU - Chan, S AU - Yang, B AU - Mohammad, N AU - Harms, J AU - Wolverton, M AU - Meyer, J AU - Arafat, R Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Use+of+Surveillance+Data+to+Evaluate+Concurrent+HIV+and+AIDS+Diagnoses+in+Houston%2FHarris+County%2C+TX&rft.au=Chan%2C+S%3BYang%2C+B%3BMohammad%2C+N%3BHarms%2C+J%3BWolverton%2C+M%3BMeyer%2C+J%3BArafat%2C+R&rft.aulast=Chan&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breaking the Cycle/Mending the Hoop: Adverse Childhood Experiences Among Incarcerated American Indian and Alaska Native Women in New Mexico T2 - 2007 National HIV Prevention Conference AN - 39609860; 4737394 JF - 2007 National HIV Prevention Conference AU - De Ravello, L AU - Abeita, J AU - Brown, P Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, New Mexico KW - USA, Alaska KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Breaking+the+Cycle%2FMending+the+Hoop%3A+Adverse+Childhood+Experiences+Among+Incarcerated+American+Indian+and+Alaska+Native+Women+in+New+Mexico&rft.au=De+Ravello%2C+L%3BAbeita%2C+J%3BBrown%2C+P&rft.aulast=De+Ravello&rft.aufirst=L&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Local Capacity Building and Training Unit: Houstons Perspective T2 - 2007 National HIV Prevention Conference AN - 39606091; 4737623 JF - 2007 National HIV Prevention Conference AU - Wiley, C P AU - Agee, G AU - Hall, H H Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39606091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Development+of+a+Local+Capacity+Building+and+Training+Unit%3A+Houstons+Perspective&rft.au=Wiley%2C+C+P%3BAgee%2C+G%3BHall%2C+H+H&rft.aulast=Wiley&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signs of the Time "Houston's Approach to Quality Management Through Realignment of Job Functions" T2 - 2007 National HIV Prevention Conference AN - 39596145; 4737449 DE: JF - 2007 National HIV Prevention Conference AU - Simpson, B AU - Washington-Philip, E AU - Kweekeh, F AU - Joseph-White, D AU - Prescott, L Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39596145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Signs+of+the+Time+%22Houston%27s+Approach+to+Quality+Management+Through+Realignment+of+Job+Functions%22&rft.au=Simpson%2C+B%3BWashington-Philip%2C+E%3BKweekeh%2C+F%3BJoseph-White%2C+D%3BPrescott%2C+L&rft.aulast=Simpson&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Indian Health Service's HIV Management System Clinical Software T2 - 2007 National HIV Prevention Conference AN - 39571826; 4737416 JF - 2007 National HIV Prevention Conference AU - Cullen, T AU - Gebremariam, C P Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Computer programs KW - Software KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39571826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Indian+Health+Service%27s+HIV+Management+System+Clinical+Software&rft.au=Cullen%2C+T%3BGebremariam%2C+C+P&rft.aulast=Cullen&rft.aufirst=T&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surveillance Dos and Donts: False Positive HIV Western Blots in Pregnant Women T2 - 2007 National HIV Prevention Conference AN - 39525546; 4737618 JF - 2007 National HIV Prevention Conference AU - Chan, S AU - Harms, J AU - Yang, B AU - Mohammad, N AU - Meyer, J AU - Wolverton, M AU - Arafat, R Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Western blotting KW - Pregnancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39525546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Surveillance+Dos+and+Donts%3A+False+Positive+HIV+Western+Blots+in+Pregnant+Women&rft.au=Chan%2C+S%3BHarms%2C+J%3BYang%2C+B%3BMohammad%2C+N%3BMeyer%2C+J%3BWolverton%2C+M%3BArafat%2C+R&rft.aulast=Chan&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Backpropagation ANN-Based Prediction of Exertional Heat Illness AN - 757015561; 18041290 AB - Exertional heat illness is primarily a multi-system disorder results from the combined effect of exertional and thermoregulation stress. The severity of exertional heat illness can be classified as mild, intermediate and severe from non-specific symptoms like thirst, myalgia, poor concentration, hysteria, vomiting, weakness, cramps, impaired judgement, headache, diarrhea, fatigue, hyperventilation, anxiety, and nausea to more severe symptoms like exertional dehydration, heat cramps, heat exhaustion, heat injury, heatstroke, rhabdomyolysis, and acute renal failure. At its early stage, it is quite difficult to find out the severity of disease with manual screening because of overlapping of symptoms. Therefore, one need to classify automatically the disease based on symptoms. The 7:10:1 backpropagation artificial neural network model has been used to predict the clinical outcome from the symptoms that are routinely available to clinicians. The model has found to be effective in differentiating the different stages of exertional heat-illness with an overall performance of 100%.[PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Aggarwal, Tarana AU - Sinha, Rakesh Kumar Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 547 EP - 50 CY - New York PB - Springer Science & Business Media VL - 31 IS - 6 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Neural networks KW - Heatstroke KW - Back propagation KW - Illnesses KW - Body Temperature Regulation KW - Humans KW - Heat Exhaustion -- diagnosis KW - Outcome Assessment (Health Care) KW - India KW - Heat Exhaustion -- physiopathology KW - Neural Networks (Computer) KW - Physical Exertion -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757015561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Backpropagation+ANN-Based+Prediction+of+Exertional+Heat+Illness&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BAggarwal%2C+Tarana%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2007-12-01&rft.volume=31&rft.issue=6&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9097-5 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2007 N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-007-9097-5 ER - TY - JOUR T1 - Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. AN - 70089026; 18247017 AB - Erlotinib (Tarceva) is a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor initially approved by the US Food and Drug Administration for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. In this report, we present the pivotal study that led to the approval of erlotinib in combination with gemcitabine (Gemzar) in patients with locally advanced/metastatic chemonaive pancreatic cancer patients. The combination demonstrated a statistically significant increase in overall survival accompanied by an increase in toxicity. Physicians and patients now have a new option for the treatment of locally advanced/metastatic adenocarcinoma of the pancreas. JF - Oncology (Williston Park, N.Y.) AU - Senderowicz, Adrian M AU - Johnson, John R AU - Sridhara, Rajeshwari AU - Zimmerman, Paul AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. adrian.senderowicz@fda.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1696 EP - 706; discussion 1706-9, 1712, 1715 VL - 21 IS - 14 SN - 0890-9091, 0890-9091 KW - Antimetabolites, Antineoplastic KW - 0 KW - Protein Kinase Inhibitors KW - Quinazolines KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Erlotinib Hydrochloride KW - DA87705X9K KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Double-Blind Method KW - Antimetabolites, Antineoplastic -- adverse effects KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Protein Kinase Inhibitors -- administration & dosage KW - Aged KW - Quinazolines -- administration & dosage KW - Deoxycytidine -- adverse effects KW - Protein Kinase Inhibitors -- adverse effects KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Quinazolines -- adverse effects KW - Male KW - Female KW - Survival Analysis KW - Pancreatic Neoplasms -- pathology KW - Adenocarcinoma -- secondary KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70089026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Erlotinib%2Fgemcitabine+for+first-line+treatment+of+locally+advanced+or+metastatic+adenocarcinoma+of+the+pancreas.&rft.au=Senderowicz%2C+Adrian+M%3BJohnson%2C+John+R%3BSridhara%2C+Rajeshwari%3BZimmerman%2C+Paul%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Senderowicz&rft.aufirst=Adrian&rft.date=2007-12-01&rft.volume=21&rft.issue=14&rft.spage=1696&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective study of red and processed meat intake in relation to cancer risk. AN - 69086300; 18076279 AB - Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites. The National Institutes of Health (NIH)-AARP (formerly the American Association for Retired Persons) Diet and Health Study is a cohort of approximately 500,000 people aged 50-71 y at baseline (1995-1996). Meat intake was estimated from a food frequency questionnaire administered at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals within quintiles of red and processed meat intake. During up to 8.2 y of follow-up, 53,396 incident cancers were ascertained. Statistically significant elevated risks (ranging from 20% to 60%) were evident for esophageal, colorectal, liver, and lung cancer, comparing individuals in the highest with those in the lowest quintile of red meat intake. Furthermore, individuals in the highest quintile of processed meat intake had a 20% elevated risk for colorectal and a 16% elevated risk for lung cancer. Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancers of the esophagus and liver. JF - PLoS medicine AU - Cross, Amanda J AU - Leitzmann, Michael F AU - Gail, Mitchell H AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. crossa@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1 VL - 4 IS - 12 KW - Index Medicus KW - Sex Factors KW - Nutrition Assessment KW - Humans KW - Aged KW - Risk Assessment KW - Lung Neoplasms -- etiology KW - Prospective Studies KW - Risk Factors KW - Surveys and Questionnaires KW - Colorectal Neoplasms -- etiology KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Esophageal Neoplasms -- etiology KW - Liver Neoplasms -- etiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Proportional Hazards Models KW - Meat Products -- adverse effects KW - Meat -- adverse effects KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=A+prospective+study+of+red+and+processed+meat+intake+in+relation+to+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BLeitzmann%2C+Michael+F%3BGail%2C+Mitchell+H%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=e325&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 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[8268766] J Natl Cancer Inst. 1995 May 3;87(9):652-61 [7752270] Biochem Biophys Res Commun. 1995 May 16;210(2):350-5 [7755610] J Urol. 1996 Mar;155(3):969-74 [8583620] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):895-9 [8634663] JAMA. 1996 May 1;275(17):1315-21 [8614116] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):161-6 [8833615] Princess Takamatsu Symp. 1995;23:232-9 [8844814] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] Nutr Cancer. 1997;27(3):256-60 [9101555] Med Sci Sports Exerc. 1997 Jun;29(6 Suppl):S1-205 [9243481] Cancer Res. 1997 Nov 15;57(22):5077-85 [9371506] Int J Cancer. 1997 Nov 27;73(5):634-8 [9398038] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Int J Cancer. 1998 May 29;76(5):659-64 [9610722] Hepatology. 1998 Jun;27(6):1563-6 [9620327] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Leuk Res. 1998 May;22(5):445-52 [9652731] J Med Microbiol. 1998 May;47(5):407-16 [9879941] Eur J Cancer Prev. 1998 Dec;7(6):455-60 [9926293] Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):25-34 [9950236] Toxicol Lett. 1998 Dec 28;102-103:441-6 [10022293] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Am J Epidemiol. 1999 May 15;149(10):925-32 [10342801] Br J Cancer. 1999 Jun;80(7):1107-13 [10362125] Gut. 1999 Jul;45(1):45-50 [10369703] Br J Cancer. 1999 May;80(3-4):591-7 [10408871] Cancer Lett. 1999 Sep 1;143(2):149-55 [10503895] Cancer Causes Control. 2003 Jun;14(5):427-38 [12946037] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):940-4 [14504209] Neuroepidemiology. 2004 Jan-Apr;23(1-2):78-84 [14739572] Am J Epidemiol. 2004 Mar 1;159(5):454-66 [14977641] Int J Cancer. 2004 Jun 20;110(3):424-8 [15095309] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Comment In: PLoS Med. 2007 Dec;4(12):e345 [18076281] Comment On: PLoS Med. 2007 Dec;4(12):e354 [18076283] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear factor-kappaB, an unappreciated tumor suppressor. AN - 69033844; 18056430 AB - The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers. JF - Cancer research AU - Chen, Fei AU - Castranova, Vince AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. fchen@cdc.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 11093 EP - 11098 VL - 67 IS - 23 KW - NF-kappa B KW - 0 KW - Index Medicus KW - Humans KW - Neoplasms -- drug therapy KW - Genes, Tumor Suppressor -- physiology KW - NF-kappa B -- physiology KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Nuclear+factor-kappaB%2C+an+unappreciated+tumor+suppressor.&rft.au=Chen%2C+Fei%3BCastranova%2C+Vince&rft.aulast=Chen&rft.aufirst=Fei&rft.date=2007-12-01&rft.volume=67&rft.issue=23&rft.spage=11093&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interaction studies of therapeutic proteins or monoclonal antibodies. AN - 69003880; 17962422 AB - Drug interactions can alter the pharmacokinetics and/or pharmacodynamics of a drug. In pharmacokinetic drug interactions, the concentrations of 1 or more drugs are altered by another. This change in concentration in a given drug may be due to changes in absorption, distribution, metabolism, or elimination. The pharmacodynamic interaction can lead to additive, synergistic, or antagonistic effects of a drug. Drug interaction studies are regularly conducted with conventional drugs (small molecules), but very few drug interaction studies have been performed with macromolecules (therapeutic proteins or monoclonal antibodies). This is mainly because most macromolecules are not metabolized by the cytochrome P450 system, and their mechanism of elimination is complex. However, it has been shown in several studies that interferons can have an impact on the cytochrome P450 system that may alter the pharmacokinetics and pharmacodynamics of a conventional drug when given with interferons. Therefore, it is important to evaluate the effect of other classes of macromolecules (cytokines, interleukins, monoclonal antibodies) on drug-metabolizing enzymes. It is also imperative that the effects of conventional drugs on the pharmacokinetics and pharmacodynamics of macromolecules be conducted. The present review encompasses several drug interaction studies that were conducted with macromolecules and highlights the impact of these studies on the pharmacokinetics and/or pharmacodynamics of the involved drugs. JF - Journal of clinical pharmacology AU - Mahmood, Iftekhar AU - Green, Martin David AD - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1451 Rockville Pike, Rockville, MD 20850, USA. Iftekhar.mahmood@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1540 EP - 1554 VL - 47 IS - 12 SN - 0091-2700, 0091-2700 KW - Antibodies, Monoclonal KW - 0 KW - Cytokines KW - Interleukins KW - Macromolecular Substances KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Cytokines -- therapeutic use KW - Cytokines -- pharmacokinetics KW - Humans KW - Interleukins -- therapeutic use KW - Interleukins -- pharmacokinetics KW - Interleukins -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytokines -- metabolism KW - Macromolecular Substances -- pharmacokinetics KW - Drug Interactions KW - Antibodies, Monoclonal -- pharmacokinetics KW - Antibodies, Monoclonal -- metabolism KW - Macromolecular Substances -- metabolism KW - Macromolecular Substances -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69003880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Drug+interaction+studies+of+therapeutic+proteins+or+monoclonal+antibodies.&rft.au=Mahmood%2C+Iftekhar%3BGreen%2C+Martin+David&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2007-12-01&rft.volume=47&rft.issue=12&rft.spage=1540&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-03 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lessons from the Avandia controversy: a new paradigm for the development of drugs to treat type 2 diabetes. AN - 68548960; 18042753 JF - Diabetes care AU - Misbin, Robert I AD - Division of Endocrinology and Metabolism, Food and Drug Administration, Silver Spring, Maryland, USA. robert.misbin@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3141 EP - 3144 VL - 30 IS - 12 KW - Hypoglycemic Agents KW - 0 KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Index Medicus KW - United States KW - Hypoglycemic Agents -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Hypoglycemic Agents -- adverse effects KW - Clinical Trials as Topic -- standards KW - Meta-Analysis as Topic KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Thiazolidinediones -- adverse effects KW - Thiazolidinediones -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68548960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Lessons+from+the+Avandia+controversy%3A+a+new+paradigm+for+the+development+of+drugs+to+treat+type+2+diabetes.&rft.au=Misbin%2C+Robert+I&rft.aulast=Misbin&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=30&rft.issue=12&rft.spage=3141&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-08 N1 - Date created - 2007-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora. AN - 68539685; 17933925 AB - The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines. JF - Applied and environmental microbiology AU - Xu, Haiyan AU - Heinze, Thomas M AU - Chen, Siwei AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 7759 EP - 7762 VL - 73 IS - 23 KW - Aniline Compounds KW - 0 KW - Azo Compounds KW - Naphthols KW - Toluidines KW - 4-nitroaniline KW - 1MRQ0QZG7G KW - 2,4-xylidine KW - 367R1L22C9 KW - 1-phenylazo-2-naphthol KW - 48I7IBB68J KW - sudan red KW - 8C1M5O3ECT KW - 2-toluidine KW - B635MZ0ZLU KW - 1-amino-2-naphthol KW - MB1ZPM5M0Z KW - sudan III KW - ND733RX3JN KW - aniline KW - SIR7XX2F1K KW - Index Medicus KW - Molecular Structure KW - Spectrometry, Mass, Electrospray Ionization KW - Aniline Compounds -- chemistry KW - Toluidines -- metabolism KW - Humans KW - Toluidines -- chemistry KW - Tandem Mass Spectrometry KW - Chromatography, High Pressure Liquid KW - Anaerobiosis KW - Aniline Compounds -- metabolism KW - Bacteria -- metabolism KW - Azo Compounds -- metabolism KW - Azo Compounds -- chemistry KW - Naphthols -- metabolism KW - Intestines -- microbiology KW - Naphthols -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68539685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Anaerobic+metabolism+of+1-amino-2-naphthol-based+azo+dyes+%28Sudan+dyes%29+by+human+intestinal+microflora.&rft.au=Xu%2C+Haiyan%3BHeinze%2C+Thomas+M%3BChen%2C+Siwei%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Xu&rft.aufirst=Haiyan&rft.date=2007-12-01&rft.volume=73&rft.issue=23&rft.spage=7759&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Microbiol Biotechnol. 2001 Jul;56(1-2):69-80 [11499949] Cancer Res. 2002 Oct 15;62(20):5678-84 [12384524] Protein Expr Purif. 2004 Apr;34(2):302-10 [15003265] J Chromatogr A. 2004 Jul 9;1042(1-2):123-30 [15296396] Appl Environ Microbiol. 1978 Mar;35(3):558-62 [25047] Biochem Biophys Res Commun. 1982 Aug 31;107(4):1224-9 [6814437] Appl Environ Microbiol. 1985 Jul;50(1):10-5 [4026284] Food Addit Contam. 2004 Oct;21(10):935-41 [15712518] Cancer Lett. 2005 Apr 8;220(2):145-54 [15766589] Microbiology. 2005 May;151(Pt 5):1433-41 [15870453] Science. 2005 Jun 10;308(5728):1635-8 [15831718] Curr Protein Pept Sci. 2006 Apr;7(2):101-11 [16611136] Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:35-9 [17159775] Mutat Res. 2007 Mar 5;627(2):164-70 [17188558] Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2927-32 [17293459] J AOAC Int. 2007 Mar-Apr;90(2):437-45 [17474514] J Agric Food Chem. 2007 May 16;55(10):3869-76 [17439236] Arch Biochem Biophys. 2007 Jul 1;463(1):68-77 [17428434] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain. AN - 68538797; 17532111 AB - Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists has shown a significant improvement of the effects of l-DOPA. The present review emphasizes the possible application of A2A receptor antagonists in pathological conditions other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A2A receptors, which presynaptically and postsynaptically regulate glutamatergic transmission in the cortical glutamatergic projections to the nucleus accumbens. It is currently believed that molecular adaptations of the cortico-accumbens glutamatergic synapses are involved in compulsive drug seeking and relapse. Here we review recent experimental evidence suggesting that A2A antagonists could become new therapeutic agents for drug addiction. Morphological and functional studies have identified lower levels of A2A receptors in brain areas other than the striatum, such as the ventrolateral preoptic area of the hypothalamus, where adenosine plays an important role in sleep regulation. Although initially believed to be mostly dependent on A1 receptors, here we review recent studies that demonstrate that the somnogenic effects of adenosine are largely mediated by hypothalamic A2A receptors. A2A)receptor antagonists could therefore be considered as a possible treatment for narcolepsy and other sleep-related disorders. Finally, nociception is another adenosine-regulated neural function previously thought to mostly involve A1 receptors. Although there is some conflicting literature on the effects of agonists and antagonists, which may partly be due to the lack of selectivity of available drugs, the studies in A2A receptor knockout mice suggest that A2A receptor antagonists might have some therapeutic potential in pain states, in particular where high intensity stimuli are prevalent. JF - Progress in neurobiology AU - Ferré, S AU - Diamond, I AU - Goldberg, S R AU - Yao, L AU - Hourani, S M O AU - Huang, Z L AU - Urade, Y AU - Kitchen, I AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, Baltimore, MD 21224, USA. sferre@intra.nida.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 332 EP - 347 VL - 83 IS - 5 SN - 0301-0082, 0301-0082 KW - Adenosine A1 Receptor Antagonists KW - 0 KW - Adenosine A2 Receptor Antagonists KW - Receptor, Adenosine A1 KW - Receptor, Adenosine A2A KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Neural Pathways -- physiopathology KW - Animals KW - Receptor, Adenosine A1 -- metabolism KW - Neural Pathways -- metabolism KW - Humans KW - Neural Pathways -- drug effects KW - Adenosine -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Pain -- drug therapy KW - Pain -- physiopathology KW - Hypothalamus -- drug effects KW - Sleep Wake Disorders -- metabolism KW - Hypothalamus -- physiopathology KW - Receptor, Adenosine A2A -- metabolism KW - Sleep Wake Disorders -- physiopathology KW - Sleep Wake Disorders -- drug therapy KW - Hypothalamus -- metabolism KW - Substance-Related Disorders -- drug therapy KW - Basal Ganglia -- physiopathology KW - Substance-Related Disorders -- metabolism KW - Basal Ganglia -- drug effects KW - Pain -- metabolism KW - Basal Ganglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68538797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neurobiology&rft.atitle=Adenosine+A2A+receptors+in+ventral+striatum%2C+hypothalamus+and+nociceptive+circuitry+implications+for+drug+addiction%2C+sleep+and+pain.&rft.au=Ferr%C3%A9%2C+S%3BDiamond%2C+I%3BGoldberg%2C+S+R%3BYao%2C+L%3BHourani%2C+S+M+O%3BHuang%2C+Z+L%3BUrade%2C+Y%3BKitchen%2C+I&rft.aulast=Ferr%C3%A9&rft.aufirst=S&rft.date=2007-12-01&rft.volume=83&rft.issue=5&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Progress+in+neurobiology&rft.issn=03010082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Neurobiol. 2004 Aug;73(6):379-96 [15313333] Alcohol Clin Exp Res. 2004 Sep;28(9):1308-16 [15365300] Eur J Neurosci. 2004 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[12445704] Pol J Pharmacol. 2002 Jul-Aug;54(4):359-66 [12523489] Eur J Pharmacol. 1994 May 12;257(1-2):21-5 [8082703] J Neurosci. 1994 Oct;14(10):6239-47 [7931576] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrauterine exposures and risk of endometriosis. AN - 68533084; 17956923 AB - Intrauterine environmental exposures have been adversely associated with male reproductive health in contrast to limited investigation of such exposures and female reproductive health. To address this research gap, a cohort comprising 84 women aged 18-40 years undergoing laparoscopy was recruited prior to surgery and followed through the post-operative period for endometriosis diagnosis. Women were interviewed about environmental exposures and those of their mothers while pregnant with them (use of alcohol, caffeinated beverages and cigarettes). Endometriosis was diagnosed in 32 women from the laparoscopy cohort; 52 women had no endometriosis visualized. Using unconditional logistic regression, odds ratios (OR) and 95% confidence intervals (CIs) were estimated for the intrauterine exposures adjusting for potential confounders. No significant associations were seen between intrauterine exposure to alcohol or caffeine and a diagnosis of endometriosis. Adjusting for age, significant reductions in odds of an endometriosis diagnosis were observed for intrauterine cigarette exposure both in the absence (OR 0.22, 95% CI 0.06-0.82) or presence (OR 0.05, 95% CI 0.01-0.42) of women's current smoking. While speculative, in utero cigarette exposure may be associated with a lower risk of surgically diagnosed adult-onset endometriosis, possibly as a result of alterations in hormonal milieu or pathologic angiogensis. JF - Human reproduction (Oxford, England) AU - Buck Louis, Germaine M AU - Hediger, Mary L AU - Peña, Josefa B AD - Department of Health and Human Services, Epidemiology Branch, National Institute of Child Health & Human Development, Rockville, Maryland 20852, USA. louisg@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3232 EP - 3236 VL - 22 IS - 12 SN - 0268-1161, 0268-1161 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Severity of Illness Index KW - Cimicifuga KW - Caffeine -- administration & dosage KW - Laparoscopy KW - Risk Factors KW - Humans KW - Adult KW - Alcohol Drinking -- epidemiology KW - Adolescent KW - Smoking -- epidemiology KW - Female KW - Pregnancy KW - Endometriosis -- epidemiology KW - Maternal Exposure -- statistics & numerical data KW - Endometriosis -- surgery KW - Prenatal Exposure Delayed Effects -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68533084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+reproduction+%28Oxford%2C+England%29&rft.atitle=Intrauterine+exposures+and+risk+of+endometriosis.&rft.au=Buck+Louis%2C+Germaine+M%3BHediger%2C+Mary+L%3BPe%C3%B1a%2C+Josefa+B&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=3232&rft.isbn=&rft.btitle=&rft.title=Human+reproduction+%28Oxford%2C+England%29&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-10 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal falls overboard on commercial fishing vessels in Alaska. AN - 68531288; 17910031 AB - Falls overboard are a major contributor to commercial fishing fatalities in Alaska. The National Institute for Occupational Safety and Health has repeatedly identified falls overboard as a critical issue in commercial fishing safety. This article describes the problem of falls overboard and discusses possible ways to reduce the risk factors. Data from the Alaska Occupational Injury Surveillance System on fatal falls overboard in Alaska between 1990 and 2005 were used. An in-depth descriptive analysis of these fatalities was performed to identify areas for intervention. There were 71 fatal falls overboard on commercial fishing vessels in Alaska during the 16-year time period. Falls overboard did not decline significantly during those years. The most common circumstances associated with falling overboard were working with fishing gear, being alone on deck, losing balance or slipping, heavy weather, gear entanglement, and alcohol. The level of involvement of those circumstances varied by region and gear type. Many fatal falls overboard may be prevented by understanding the circumstances involved and targeting interventions at those specific risk factors. Interventions include creating more enclosed work spaces, managing lines, avoiding fishing alone, wearing personal flotation devices and man overboard alarms, and reducing alcohol use. Subsequent research should identify further interventions for each circumstance and evaluate the effectiveness of these interventions with the fishing industry. JF - American journal of industrial medicine AU - Lucas, Devin L AU - Lincoln, Jennifer M AD - National Institute for Occupational Safety and Health, Alaska Field Station, Anchorage, Alaska 99508, USA. dlucas@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 962 EP - 968 VL - 50 IS - 12 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Epidemiologic Studies KW - Risk Factors KW - Humans KW - Alaska -- epidemiology KW - Adult KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Ships KW - Drowning -- epidemiology KW - Occupational Health KW - Drowning -- etiology KW - Accidental Falls -- mortality KW - Fisheries -- statistics & numerical data KW - Drowning -- mortality KW - Accidents, Occupational -- statistics & numerical data KW - Accidental Falls -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68531288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Fatal+falls+overboard+on+commercial+fishing+vessels+in+Alaska.&rft.au=Lucas%2C+Devin+L%3BLincoln%2C+Jennifer+M&rft.aulast=Lucas&rft.aufirst=Devin&rft.date=2007-12-01&rft.volume=50&rft.issue=12&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. AN - 68530329; 17875604 AB - The cystine-glutamate transporter SLC7A11 has been implicated in chemoresistance, by supplying cystine to the cell for glutathione maintenance. In the NCI-60 cell panel, SLC7A11 expression shows negative correlation with growth inhibitory potency of geldanamycin but not with its analog 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), which differs in the C-17 substituent in that the the methoxy moiety of geldanamycin is replaced by an amino group. Structure and potency analysis classified 18 geldanamycin analogs into two subgroups, "17-O/H" (C-17 methoxy or unsubstituted) and "17-N" (C-17 amino), showing distinct SLC7A11 correlation. We used three 17-O/H analogs and four 17-N analogs to test the role of the 17-substituents in susceptibility to SLC7A11-mediated resistance. In A549 cells, which are resistant to geldanamycin and strongly express SLC7A11, inhibition of SLC7A11 by (S)-4-carboxyphenylglycine or small interfering RNA increased sensitivity to 17-O/H, but had no effect on 17-N analogs. Ectopic expression of SLC7A11 in HepG2 cells, which are sensitive to geldanamycin and express low SLC7A11, confers resistance to geldanamycin, but not to 17-AAG. Antioxidant N-acetylcysteine, a precursor for glutathione synthesis, completely suppressed cytotoxic effects of 17-O/H but had no effect on 17-N analogs, whereas the prooxidant ascorbic acid had the opposite effect. Compared with 17-AAG, geldanamycin led to significantly more intracellular reactive oxygen species (ROS) production, which was quenched by addition of N-acetylcysteine. We conclude that SLC7A11 confers resistance selectively to 17-O/H (e.g., geldanamycin) but not to 17-N (e.g., 17-AAG) analogs partly as a result of differential dependence on ROS for cytotoxicity. Distinct mechanisms could significantly affect antitumor response and organ toxicity of these compounds in vivo. JF - Molecular pharmacology AU - Liu, Ruqing AU - Blower, Paul E AU - Pham, Anh-Nhan AU - Fang, Jialong AU - Dai, Zunyan AU - Wise, Carolyn AU - Green, Bridgette AU - Teitel, Candee H AU - Ning, Baitang AU - Ling, Wenhua AU - Lyn-Cook, Beverly D AU - Kadlubar, Fred F AU - Sadée, Wolfgang AU - Huang, Ying AD - Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1637 EP - 1646 VL - 72 IS - 6 KW - Amino Acid Transport System y+ KW - 0 KW - Benzoquinones KW - Lactams, Macrocyclic KW - SLC7A11 protein, human KW - tanespimycin KW - 4GY0AVT3L4 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Humans KW - Cell Line, Tumor KW - Drug Screening Assays, Antitumor -- methods KW - Structure-Activity Relationship KW - Benzoquinones -- chemistry KW - Benzoquinones -- pharmacology KW - Lactams, Macrocyclic -- chemistry KW - Amino Acid Transport System y+ -- metabolism KW - Lactams, Macrocyclic -- pharmacology KW - Drug Resistance, Neoplasm -- physiology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68530329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Cystine-glutamate+transporter+SLC7A11+mediates+resistance+to+geldanamycin+but+not+to+17-%28allylamino%29-17-demethoxygeldanamycin.&rft.au=Liu%2C+Ruqing%3BBlower%2C+Paul+E%3BPham%2C+Anh-Nhan%3BFang%2C+Jialong%3BDai%2C+Zunyan%3BWise%2C+Carolyn%3BGreen%2C+Bridgette%3BTeitel%2C+Candee+H%3BNing%2C+Baitang%3BLing%2C+Wenhua%3BLyn-Cook%2C+Beverly+D%3BKadlubar%2C+Fred+F%3BSad%C3%A9e%2C+Wolfgang%3BHuang%2C+Ying&rft.aulast=Liu&rft.aufirst=Ruqing&rft.date=2007-12-01&rft.volume=72&rft.issue=6&rft.spage=1637&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature. AN - 68529549; 17922878 AB - The aetiology of chronic lymphocytic leukaemia (CLL) is largely unknown. Despite compelling evidence for ionising radiation as a cause of most forms of leukaemia, CLL was not found to be radiogenic in early studies. Herein we describe the recent evidence for causation of CLL by ionising and non-ionising radiation, including a nested case-control study conducted within a cohort of 94 517 US workers at four nuclear weapons facilities and a nuclear naval shipyard. Forty-three cases of CLL deaths and 172 age-matched controls were identified with follow-up up to between 1990 and 1996. Radiation exposure from external sources and plutonium (lagged 10 years) was assessed for each worker, based on monitoring records. The excess relative rate (ERR) was estimated for workers receiving elevated doses compared to unexposed workers, controlling for possible risk factors. The ERR per 10 mSv was -0.020 (95% confidence interval: <0, 0.14) based on all exposed workers. However, for workers receiving <100 mSv, the ERR per 10 mSv was 0.20 (-0.035, 0.96). Recent studies of uranium miners and other populations have shown elevations of CLL possibly associated with ionising and non-ionising radiation. New studies should use incident cases and sufficient latency to account for the expected lengthy induction period for CLL. JF - British journal of haematology AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AU - Fleming, Donald A AU - Markey, Andrea M AU - Couch, James R AU - Ahrenholz, Steven H AU - Burphy, Jenneh S AU - Anderson, Jeri L AU - Tseng, Chih-Yu AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH, USA. zcg3@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 799 EP - 808 VL - 139 IS - 5 KW - Index Medicus KW - Radiation Dosage KW - Epidemiologic Methods KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Radiometry -- methods KW - United States -- epidemiology KW - Occupational Exposure -- analysis KW - Male KW - Female KW - Leukemia, Radiation-Induced -- etiology KW - Occupational Diseases -- etiology KW - Leukemia, Radiation-Induced -- mortality KW - Leukemia, Lymphocytic, Chronic, B-Cell -- etiology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- mortality KW - Occupational Diseases -- mortality KW - Nuclear Weapons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68529549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Chronic+lymphocytic+leukaemia+and+radiation%3A+findings+among+workers+at+five+US+nuclear+facilities+and+a+review+of+the+recent+literature.&rft.au=Schubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D%3BFleming%2C+Donald+A%3BMarkey%2C+Andrea+M%3BCouch%2C+James+R%3BAhrenholz%2C+Steven+H%3BBurphy%2C+Jenneh+S%3BAnderson%2C+Jeri+L%3BTseng%2C+Chih-Yu&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models. AN - 68529060; 17703860 AB - This report presents a comparison of the predictive performance of MC4PC and MDL-QSAR software as well as a method for combining the predictions from both programs to increase overall accuracy. The conclusions are based on 10 x 10% leave-many-out internal cross-validation studies using 1540 training set compounds with 2-year rodent carcinogenicity findings. The models were generated using the same weight of evidence scoring method previously developed [Matthews, E.J., Contrera, J.F., 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharmacol. 28, 242-264.]. Although MC4PC and MDL-QSAR use different algorithms, their overall predictive performance was remarkably similar. Respectively, the sensitivity of MC4PC and MDL-QSAR was 61 and 63%, specificity was 71 and 75%, and concordance was 66 and 69%. Coverage for both programs was over 95% and receiver operator characteristic (ROC) intercept statistic values were above 2.00. The software programs had complimentary coverage with none of the 1540 compounds being uncovered by both MC4PC and MDL-QSAR. Merging MC4PC and MDL-QSAR predictions improved the overall predictive performance. Consensus sensitivity increased to 67%, specificity to 84%, concordance to 76%, and ROC to 4.31. Consensus rules can be tuned to reflect the priorities of the user, so that greater emphasis may be placed on predictions with high sensitivity/low false negative rates or high specificity/low false positive rates. Sensitivity was optimized to 75% by reclassifying all compounds predicted to be positive in MC4PC or MDL-QSAR as positive, and specificity was optimized to 89% by reclassifying all compounds predicted negative in MC4PC or MDL-QSAR as negative. JF - Regulatory toxicology and pharmacology : RTP AU - Contrera, Joseph F AU - Kruhlak, Naomi L AU - Matthews, Edwin J AU - Benz, R Daniel AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Joseph.Contrera@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 172 EP - 182 VL - 49 IS - 3 SN - 0273-2300, 0273-2300 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Toxicity Tests, Chronic -- methods KW - Databases, Factual KW - Carcinogenicity Tests -- methods KW - Data Interpretation, Statistical KW - Mice KW - Toxicity Tests, Chronic -- trends KW - Models, Theoretical KW - Pharmaceutical Preparations -- administration & dosage KW - Software KW - Quantitative Structure-Activity Relationship KW - Pharmaceutical Preparations -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68529060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Comparison+of+MC4PC+and+MDL-QSAR+rodent+carcinogenicity+predictions+and+the+enhancement+of+predictive+performance+by+combining+QSAR+models.&rft.au=Contrera%2C+Joseph+F%3BKruhlak%2C+Naomi+L%3BMatthews%2C+Edwin+J%3BBenz%2C+R+Daniel&rft.aulast=Contrera&rft.aufirst=Joseph&rft.date=2007-12-01&rft.volume=49&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interactions in the management of HIV infection: an update. AN - 68516515; 18001255 AB - Improvement in the availability of antiretroviral (ARV) therapy continues to reduce HIV morbidity and mortality. With more treatment choices and better accessibility, the extent of medication use among patients with HIV/AIDS continues to grow. ARV drugs are particularly prone to drug interactions as a consequence of their metabolic and pharmacokinetic properties. The recognition and management of drug interactions in patients on ARVs is a constant challenge to medical providers. Staying abreast of drug interaction knowledge is complicated by the rate at which new information becomes available through in vivo investigation, case reports and pharmacokinetic studies. In addition, distinguishing the clinical significance of an interaction is difficult due to the large interpatient variability in pharmacokinetics exhibited by most ARV agents. This review provides an update to a previous review article published in 2005, and is intended to improve the reader's knowledge of drug interactions in the management of HIV infection. JF - Expert opinion on pharmacotherapy AU - Robertson, Sarah M AU - Penzak, Scott R AU - Pau, Alice AD - US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2947 EP - 2963 VL - 8 IS - 17 KW - Anti-HIV Agents KW - 0 KW - HIV Protease Inhibitors KW - Reverse Transcriptase Inhibitors KW - Index Medicus KW - Humans KW - Drug Monitoring KW - Treatment Outcome KW - Drug Interactions KW - Anti-HIV Agents -- pharmacokinetics KW - Reverse Transcriptase Inhibitors -- pharmacokinetics KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - HIV Infections -- metabolism KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - Reverse Transcriptase Inhibitors -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68516515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+pharmacotherapy&rft.atitle=Drug+interactions+in+the+management+of+HIV+infection%3A+an+update.&rft.au=Robertson%2C+Sarah+M%3BPenzak%2C+Scott+R%3BPau%2C+Alice&rft.aulast=Robertson&rft.aufirst=Sarah&rft.date=2007-12-01&rft.volume=8&rft.issue=17&rft.spage=2947&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+pharmacotherapy&rft.issn=1744-7666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. AN - 68473195; 17586532 AB - Peroxisome proliferators are potent rodent liver carcinogens that act via a non-genotoxic mechanism. The mode of action of these agents in rodent liver includes increased cell proliferation, decreased apoptosis, secondary oxidative stress and other events; however, it is not well understood how peroxisome proliferators are triggering the plethora of the molecular signals leading to cancer. Epigenetic changes have been implicated in the mechanism of liver carcinogenesis by a number of environmental agents. Short-term treatment with peroxisome proliferators and other non-genotoxic carcinogens leads to global and locus-specific DNA hypomethylation in mouse liver, events that were suggested to correlate with a burst of cell proliferation. In the current study, we investigated the effects of long-term exposure to a model peroxisome proliferator WY-14,643 on DNA and histone methylation. Male SV129mice were fed a control or WY-14,643-containing (1000ppm) diet for one week, five weeks or five months. Treatment with WY-14,643 led to progressive global hypomethylation of liver DNA as determined by an HpaII-based cytosine extension assay with the maximum effect reaching over 200% at five months. Likewise, trimethylation of histone H4 lysine 20 and H3 lysine 9 was significantly decreased at all time points. The majority of cytosine methylation in mammals resides in repetitive DNA sequences. In view of this, we measured the effect of WY-14,643 on the methylation status of major and minor satellites, as well as in IAP, LINE1 and LINE2 elements in liver DNA. Exposure to WY-14,643 resulted in a gradual loss of cytosine methylation in major and minor satellites, IAP, LINE1 and LINE2 elements. The epigenetic changes correlated with the temporal effects of WY-14,643 on cell proliferation rates in liver, but no sustained effect on c-Myc promoter methylation was observed. Finally, WY-14,643 had no effect on DNA and histone methylation status in Pparalpha-null mice at any of the time points considered in this study. These data indicate the importance of epigenetic alterations in the mechanism of action of peroxisome proliferators and the key role of Pparalpha. JF - Mutation research AU - Pogribny, Igor P AU - Tryndyak, Volodymyr P AU - Woods, Courtney G AU - Witt, Sarah E AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 62 EP - 71 VL - 625 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - DNA Primers KW - Histones KW - PPAR alpha KW - Peroxisome Proliferators KW - Pyrimidines KW - Retroelements KW - pirinixic acid KW - 86C4MRT55A KW - Index Medicus KW - Animals KW - Base Sequence KW - Terminal Repeat Sequences -- drug effects KW - DNA Primers -- genetics KW - Histones -- metabolism KW - DNA Methylation -- drug effects KW - CpG Islands -- drug effects KW - Carcinogens -- toxicity KW - Retroelements -- drug effects KW - Long Interspersed Nucleotide Elements -- drug effects KW - Mice KW - Male KW - Mice, Knockout KW - PPAR alpha -- deficiency KW - Epigenesis, Genetic -- physiology KW - Liver -- drug effects KW - Pyrimidines -- toxicity KW - Peroxisome Proliferators -- toxicity KW - Epigenesis, Genetic -- drug effects KW - Liver -- metabolism KW - PPAR alpha -- metabolism KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68473195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Epigenetic+effects+of+the+continuous+exposure+to+peroxisome+proliferator+WY-14%2C643+in+mouse+liver+are+dependent+upon+peroxisome+proliferator+activated+receptor+alpha.&rft.au=Pogribny%2C+Igor+P%3BTryndyak%2C+Volodymyr+P%3BWoods%2C+Courtney+G%3BWitt%2C+Sarah+E%3BRusyn%2C+Ivan&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2007-12-01&rft.volume=625&rft.issue=1-2&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] J Mol Med (Berl). 2005 Oct;83(10):774-85 [15976920] Eur J Cancer. 2005 Nov;41(16):2381-402 [16226460] Nat Rev Genet. 2006 Jan;7(1):21-33 [16369569] EXS. 2006;(96):321-49 [16383025] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] Genome Res. 2006 Feb;16(2):157-63 [16365381] Nucleic Acids Res. 1997 Jun 15;25(12):2532-4 [9171110] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Oncogene. 2004 Nov 18;23(54):8841-6 [15480421] Cell. 2004 Nov 24;119(5):603-14 [15550243] EMBO J. 2005 Feb 23;24(4):800-12 [15678104] Crit Rev Toxicol. 2005 Jan;35(1):61-88 [15742903] Nat Genet. 2005 Apr;37(4):391-400 [15765097] Toxicol Sci. 2005 Oct;87(2):344-52 [16014735] Toxicol Sci. 2006 Apr;90(2):269-95 [16322072] Toxicol Sci. 2006 Jun;91(2):393-405 [16537655] Carcinogenesis. 2006 Aug;27(8):1713-20 [16632870] Curr Top Microbiol Immunol. 2006;310:211-50 [16909913] Curr Top Microbiol Immunol. 2006;310:251-74 [16909914] Anal Biochem. 2006 Sep 15;356(2):202-7 [16824473] Crit Rev Toxicol. 2006 May;36(5):459-79 [16954067] J Nutr. 2007 Jan;137(1 Suppl):216S-222S [17182829] Cancer Res. 2007 Feb 1;67(3):946-50 [17283125] Mol Carcinog. 2007 Mar;46(3):187-97 [17219426] Toxicol Sci. 2007 Aug;98(2):366-74 [17483499] Regul Toxicol Pharmacol. 2000 Oct;32(2):135-43 [11067770] Carcinogenesis. 2000 Dec;21(12):2141-5 [11133801] Antioxid Redox Signal. 2000 Fall;2(3):607-21 [11229371] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Cell. 2001 Nov 2;107(3):323-37 [11701123] Mol Cell Biol. 2002 Jan;22(2):480-91 [11756544] Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10060-5 [12110732] Toxicol Lett. 2002 Aug 5;134(1-3):51-6 [12191860] Toxicol Sci. 2003 Oct;75(2):289-99 [12883089] Adv Cancer Res. 2003;90:209-30 [14710952] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] EMBO J. 2004 Feb 11;23(3):605-15 [14765126] Science. 2004 Mar 12;303(5664):1626-32 [15016989] J Cell Sci. 2004 May 15;117(Pt 12):2491-501 [15128874] Nucleic Acids Res. 2004;32(14):4100-8 [15302911] Cancer Res. 1979 Jan;39(1):152-61 [83907] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Cancer Res. 1997 Feb 15;57(4):594-9 [9044832] Mutat Res. 1997 Apr;386(2):141-52 [9113115] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spousal concordance for substance use and anxiety disorders. AN - 68182937; 17204289 AB - Assortative mating -- the tendency for mate selection to occur on the basis of similar traits -- plays an essential role in understanding the genetic contribution to psychiatric illness. It also carries significant impact on clinical prognosis and is an important mechanism explaining spousal concordance. This study uses a family study design ascertaining 225 probands with substance abuse/dependence, anxiety disorders, and controls to address: (1) Is there spousal concordance or cross-concordance for substance use and/or anxiety disorders? (2) Is the spousal concordance or cross-concordance associated with worse clinical outcomes? (3) What is the mechanism of the concordance or cross-concordance? Results show a high magnitude of spousal concordance for substance use disorders with a third of the substance probands' spouses also substance dependent. In contrast, there was no spousal concordance for anxiety disorders. Couples were also concordant for having "no disorders." Both substance use and anxiety disorder concordance were associated with poorer global functioning and persistent illness. Assortative mating is a likely mechanism for spousal concordance given the elevated rate of substance use disorders among the relatives of spouses' of substance probands. Implications for family/genetic studies and the transmission of substance use disorders and "no disorders" include: (1) at the individual level, spousal concordance influences probands' course of illness, couples' marital functioning, and offspring's genetic and environmental context; and (2) at the population level, it shifts the general distribution of substance use disorders and "no disorders" by reducing the "average" couple concordance and increasing the number concordant and discordant couples at extremes of the distribution. JF - Journal of psychiatric research AU - Low, Nancy AU - Cui, Lihong AU - Merikangas, Kathleen R AD - Section on Developmental Genetic Epidemiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. Nancy.Low@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 942 EP - 951 VL - 41 IS - 11 SN - 0022-3956, 0022-3956 KW - Index Medicus KW - Humans KW - Marriage -- statistics & numerical data KW - Comorbidity KW - Mood Disorders -- genetics KW - Phenotype KW - Interview, Psychological KW - Marriage -- psychology KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Mood Disorders -- epidemiology KW - Mood Disorders -- psychology KW - Female KW - Male KW - Anxiety Disorders -- genetics KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Spouses -- statistics & numerical data KW - Spouses -- psychology KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- epidemiology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Spousal+concordance+for+substance+use+and+anxiety+disorders.&rft.au=Low%2C+Nancy%3BCui%2C+Lihong%3BMerikangas%2C+Kathleen+R&rft.aulast=Low&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=41&rft.issue=11&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Crossing the Line: Observations from East Detroit, Michigan, USA AN - 61420955; 200907042 AB - This is an experimental piece that reports on findings from a research project conducted from September to December 2006 on the border between a neighborhood on the east side of Detroit (Jefferson Chalmers) and Grosse Pointe Park, Michigan. The project addresses the stark racial, economic, and physical divides between two proximate communities, and the way that the boundary line between these communities is enacted. Alter Road, serves as this real and infrequently crossed border. The physical barriers put in place to reinforce the imaginary line between East Detroit,1 and Grosse Pointe Park and the conditions on either side of the border are prominent themes. For social workers, understanding how and why bordering communities remain insular, and the effect of that segregation, is important in understanding human behavior and better appreciating the circumstances from which people come. This qualitative piece illustrates these issues through the eyes of a graduate social work student walking again and again across that boundary. [Reprinted by permission of Sage Publications Ltd., copyright 2007.] JF - Qualitative Social Work AU - Martin, Megan C AD - Department of Health and Human Services, Washington, DC, USA megcmartin@gmail.com Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 465 EP - 475 PB - Sage Publications, London UK VL - 6 IS - 4 SN - 1473-3250, 1473-3250 KW - borders neighborhood observational research race KW - Borders KW - Neighborhoods KW - Race KW - Detroit, Michigan KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61420955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Social+Work&rft.atitle=Crossing+the+Line%3A+Observations+from+East+Detroit%2C+Michigan%2C+USA&rft.au=Martin%2C+Megan+C&rft.aulast=Martin&rft.aufirst=Megan&rft.date=2007-12-01&rft.volume=6&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Qualitative+Social+Work&rft.issn=14733250&rft_id=info:doi/10.1177%2F1473325007083357 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-10-02 N1 - Number of references - 4 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Detroit, Michigan; Race; Neighborhoods; Borders DO - http://dx.doi.org/10.1177/1473325007083357 ER - TY - JOUR T1 - Selection into specialty training in public health: performance of the Medical Training Application Service shortlisting AN - 57253381; 200816438 AB - Objective: To assess the performance of shortlisting against appointability to public health specialty training under the Medical Training Application Service (MTAS) selection methodology using multiple modality in person assessment. Methods: Candidates who had applied to public health specialty training programme in Wales and East of England and shortlisted were assessed in the first assessment round. Further to MTAS review, candidates not previously short listed were offered assessment in the second round. Receiver operating characteristic (ROC) analysis was done. Results: In both the programmes, the shortlisting scores of candidates considered appointable were substantially higher than those considered not appointable, a score difference of 13.0 (95% confidence interval (CI) 3.0-23.0) and 13.5 (95% CI 3.4-23.5) respectively. The area under the ROC curve (ROCAUC) was 0.88 (95% CI 0.63-1.00) in Wales and 0.77 (95% CI 0.57-0.97) in East of England. The shortlisting scores of the two programmes that gave an optimum performance (maximum sum of the sensitivity and specificity) were comparable (scores of 62 and 63 respectively). Conclusion: MTAS shortlisting undertaken in two independent public health specialty training programmes discriminated well between appointable and not appointable candidates. Adapted from the source document. JF - Journal of Public Health AU - Pashayan, Nora AU - Duff, Celia AU - Mason, Brendan W AD - National Public Health Service for Wales, The Temple of Peace and Health, Cathays Parks, Cardiff CF10 3NW, UK Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 331 EP - 337 PB - Oxford University Press VL - 29 IS - 4 SN - 1741-3842, 1741-3842 KW - medical training application service (MTAS), specialty training, postgraduate medical education, assessment centre, receiver operating characteristic analysis KW - Assessment KW - Receiver operating characteristic analysis KW - Training KW - Application KW - Specialization KW - Medical education KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Selection+into+specialty+training+in+public+health%3A+performance+of+the+Medical+Training+Application+Service+shortlisting&rft.au=Pashayan%2C+Nora%3BDuff%2C+Celia%3BMason%2C+Brendan+W&rft.aulast=Pashayan&rft.aufirst=Nora&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdm060 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Receiver operating characteristic analysis; Specialization; Training; Medical education; Assessment; Application DO - http://dx.doi.org/10.1093/pubmed/fdm060 ER - TY - JOUR T1 - Occupational and Non-Occupational Injuries in the United States Army: Focus on Gender AN - 57231500; 200805319 AB - Background The differences in occupational and non-occupational injuries between military men and women have not been documented. This study compares occupational and non-occupational injuries between male and female United States Army soldiers by examining injury hospitalization rates and characteristics. Methods The U.S. Army's Total Army Injury and Health Outcomes Database was searched for hospitalizations with ICD-9-CM codes for injury (800-959.9) between 1992 and 2002. Injury rates were calculated using yearly U.S. Army population data and compared using rate ratios. Injury characteristics were compared among categories of the Trauma Code (on duty; off duty; scheduled training, schemes, and exercises), stratified by gender. Results Included in this analysis were 792 women for an injury hospitalization rate of 11.0 per 1000 individuals (95% confidence interval [CI]=8.5-13.5) and 4879 men for a rate of 15.5 per 1000 individuals (95% CI=14.0-16.9). While women had significantly more injuries during scheduled training, schemes, and exercises than men (p<0.0001), there were few differences in the cause of those injuries. Women had longer average hospital stays compared to men due to these injuries (9.3 days vs 7.4 days, p=0.002), although these injuries were not more severe (average Injury Severity Score=3.5 for men vs average ISS for women=3.5, p=0.79). There was no difference between the genders in the percent of injuries that occurred off duty; however, men were more likely to get injured due to sports and athletics (p=0.001) and due to fighting (p=0.017) while off duty compared to women. Conclusions Injury prevention messages for military personnel should focus on reducing risk factors for both on- and off-duty injuries. [Copyright 2007 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Tiesman, Hope M AU - Peek-Asa, Corinne L AU - Zwerling, Craig S AU - Sprince, Nancy L AU - Amoroso, Paul J AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia htiesman@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 464 EP - 470 PB - Elsevier Science, New York NY VL - 33 IS - 6 SN - 0749-3797, 0749-3797 KW - Hospitalization KW - Injuries KW - Industrial accidents KW - Soldiers KW - Out of working hours KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Occupational+and+Non-Occupational+Injuries+in+the+United+States+Army%3A+Focus+on+Gender&rft.au=Tiesman%2C+Hope+M%3BPeek-Asa%2C+Corinne+L%3BZwerling%2C+Craig+S%3BSprince%2C+Nancy+L%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-12-01&rft.volume=33&rft.issue=6&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.07.034 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Industrial accidents; Injuries; Soldiers; Gender differences; Out of working hours; Hospitalization DO - http://dx.doi.org/10.1016/j.amepre.2007.07.034 ER - TY - CPAPER T1 - Cbl-dependent Regulation of LAT-nucleated Signaling Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582675; 4738737 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Balagopalan, L AU - Barr, V A AU - Sommers, C L AU - Barda-Saad, M AU - Goyal, A AU - Isakowitz, M E AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cbl-dependent+Regulation+of+LAT-nucleated+Signaling+Complexes&rft.au=Balagopalan%2C+L%3BBarr%2C+V+A%3BSommers%2C+C+L%3BBarda-Saad%2C+M%3BGoyal%2C+A%3BIsakowitz%2C+M+E%3BSamelson%2C+L+E&rft.aulast=Balagopalan&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - Table of contents AN - 236493173 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236493173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDY OF GENISTEIN (CAS NO. 446-72-0) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 236471144; 18685716 AB - Genistein is an isoflavone that occurs in soy products including soy-based infant formulas. Genistein is one of a class of chemicals known as "environmental estrogens" which can affect the homione activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure to such chemicals over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats were exposed to genistein for part or all of the study period and examined at the end of two years. The study consisted of three separate study components; in each, animals were exposed to genistein from the time of conception and through weaning through theft mothers, who were given genistein in their feed. In one study, we gave feed containing 5, 100, or 500 parts per million (ppm) of genistein to groups of 50 male and female rats from conception through two years. In the second study, groups of 50 male and female rats were given the same feed concentrations up to 20 weeks following birth, followed by untreated feed for the remainder of the two years. In the third study, groups of 50 male and female rats were exposed from conception through weaning, and then given untreated feed for the duration of the study. Control animals received the same feed with no chemical added. At the end of the study, tissues from more than 40 sites were examined for every animal. In none of the three studies were there any increased rates of cancer in male rats. In female rats exposed to genistein from conception and throughout two years, the rates of adenoma or adenocarcinoma of the mammary gland and pituitary gland adenoma or carcinoma were increased. In female rats exposed to genistein for 20 weeks following birth, the rates of pituitary gland adenoma or carcinoma were slightly increased, and in female rats exposed to genistein just from conception through weaning, the rates of mammary gland adenoma or adenocarcinoma were slightly increased. We conclude that exposure to genistein for two years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to genistein for shorter durations following birth was also possibly associated with increased rates of pituitary gland and mammary gland tumors. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1 EP - 240 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Phytoestrogens KW - Xenobiotics KW - Genistein KW - Toxicology KW - Carcinogens KW - Rodents KW - Chemicals KW - Pituitary gland KW - Pituitary Neoplasms -- chemically induced KW - Animals KW - Litter Size -- drug effects KW - Kidney -- pathology KW - Mammary Glands, Animal -- drug effects KW - Mammary Neoplasms, Animal -- pathology KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Mammary Neoplasms, Animal -- chemically induced KW - Neoplasms, Experimental -- pathology KW - Estrous Cycle -- drug effects KW - Pregnancy KW - Rats KW - Prenatal Exposure Delayed Effects -- pathology KW - Rats, Sprague-Dawley KW - Pituitary Neoplasms -- pathology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Mammary Glands, Animal -- pathology KW - Body Weight -- drug effects KW - Female KW - Male KW - Phytoestrogens -- toxicity KW - Reproduction -- drug effects KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests, Chronic KW - Genistein -- toxicity KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236471144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDY+OF+GENISTEIN+%28CAS+NO.+446-72-0%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236458206 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236458206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology AN - 211952861 AB - Solid-phase peptide synthesis (SPPS), pioneered by Merrifield in 1963, is an essential method for synthesizing peptides in the laboratory. In SPPS the "solid state" is a polymeric resin bead with a functional group to which amino acids are chemically attached one-by-one until the desired peptide sequence is achieved. Here, Qvit et al detail how the synthesis and characterization of three dipeptide analogs of aspartame is demonstrated using the tea bag methodology, and how solid-phase methodology using the Fmoc chemistry is employed in this experiment. JF - Journal of Chemical Education AU - Qvit, Nir AU - Barda, Yaniv AU - Gilon, Chaim AU - Shalev, Deborah E Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1988 CY - Easton PB - American Chemical Society VL - 84 IS - 12 SN - 00219584 KW - Chemistry KW - Peptides KW - Amino acids KW - Chemical synthesis KW - Biochemistry KW - Artificial sweeteners UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211952861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chemical+Education&rft.atitle=A+Laboratory+Preparation+of+Aspartame+Analogs+Using+Simultaneous+Multiple+Parallel+Synthesis+Methodology&rft.au=Qvit%2C+Nir%3BBarda%2C+Yaniv%3BGilon%2C+Chaim%3BShalev%2C+Deborah+E&rft.aulast=Qvit&rft.aufirst=Nir&rft.date=2007-12-01&rft.volume=84&rft.issue=12&rft.spage=1988&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chemical+Education&rft.issn=00219584&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Chemical Society Dec 2007 N1 - Document feature - References; Diagrams N1 - Last updated - 2014-05-18 N1 - CODEN - JCEDA8 ER - TY - JOUR T1 - Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest TT - Producao de serrapilheira no Cerrado e Floresta de Transicao Amazonia-Cerrado do Centro-Oeste Brasileiro AN - 20976130; 8560998 AB - (Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest). The objective of the present work was to verify the variation of litterfall production of different biomass: a cerrado ("savanna") with vegetation types Cerrado sensu stricto ("orchard-like vegetation") and Cerradao ("woodland-like vegetation") and Amazonia-Cerrado transition forest in a tropical climate. To determine the litterfall production, we used nylon screen traps. Micrometereologic data was collected in both areas of study. The litterfall in two biomass revealed themselves as seasonal, with the highest productions occurring during the dry season and the lowest during the wet. The biggest litterfall occurred in the Transition Forest, followed by the Cerrado biome. Leaf fraction was more representative than twigs, flowers, fruits in both areas studied. JF - Acta Amazonica AU - Silva, CJD AU - Sanches, L AU - Bleich, ME AU - Lobo, FDA AU - Nogueira, JDS AD - Universidade do Estado de Mato Grosso, Campus de Alta Floresta, Departamento de Engenharia Florestal, cjsnx@yahoo.com.br Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 543 EP - 548 VL - 37 IS - 4 SN - 0044-5967, 0044-5967 KW - Ecology Abstracts KW - Fruits KW - Flowers KW - Data processing KW - Climate KW - Traps KW - Vegetation KW - Forests KW - Biomass KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20976130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Amazonica&rft.atitle=Litterfall+production+in+the+Brazilian+mid-western+Amazonia-Cerrado+transition+forest&rft.au=Silva%2C+CJD%3BSanches%2C+L%3BBleich%2C+ME%3BLobo%2C+FDA%3BNogueira%2C+JDS&rft.aulast=Silva&rft.aufirst=CJD&rft.date=2007-12-01&rft.volume=37&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Acta+Amazonica&rft.issn=00445967&rft_id=info:doi/ LA - Portuguese DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Forests; Vegetation; Biomass; Traps; Data processing; Fruits; Climate; Flowers ER - TY - JOUR T1 - Chronic lymphocytic leukemia radiogenicity: a systematic review AN - 20735942; 7970545 AB - Objective: Chronic lymphocytic leukemia (CLL) is generally considered to be non-radiogenic and is excluded from several programs that compensate workers for illnesses resulting from occupational exposures. Questions about whether this exclusion is justified prompted a Congressional mandate to the National Institute for Occupational Safety and Health (NIOSH) to, further, examine the radiogenicity of CLL. This study revisits the question of CLL radiogenicity by examining epidemiologic evidence from occupationally and medically-exposed populations. Methods: A systematic review of radiation-exposed cohorts was conducted to investigate the association between radiation and CLL. Exploratory power calculations for a pooled occupational study were performed to examine the feasibility of assessing CLL radiogenicity epidemiologically. Results: There is a bias against reporting CLL results, because of the disease's presumed non-radiogenicity. In medical cohort studies that provide risk estimates for CLL, risk is elevated, though non-significantly, in almost all studies with more than 15 years average follow-up. The results of occupational studies are less consistent. Conclusions: Studies with adequate follow-up time and power are needed to better understand CLL radiogenicity. Power analyses show that a pooled study might detect risk on the order of radiation induced non-CLL leukemia, but is unlikely to detect smaller risks. JF - Cancer Causes & Control AU - Silver, Sharon R AU - Hiratzka, Shannon L AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AD - National Institute for Occupational Safety and Health (NIOSH), 5555 Ridge, Cincinnati, OH, USA, ssilver@cdc.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1077 EP - 1093 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Feasibility studies KW - Leukemia KW - Workers KW - Radiation KW - Reviews KW - Occupational safety KW - Chronic lymphatic leukemia KW - Cancer KW - Occupational exposure KW - R2 23020:Technological risks KW - F 06915:Cancer Immunology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20735942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Chronic+lymphocytic+leukemia+radiogenicity%3A+a+systematic+review&rft.au=Silver%2C+Sharon+R%3BHiratzka%2C+Shannon+L%3BSchubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1077&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9048-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Workers; Radiation; Reviews; Chronic lymphatic leukemia; Occupational exposure; Feasibility studies; Leukemia; Occupational safety; Cancer DO - http://dx.doi.org/10.1007/s10552-007-9048-y ER - TY - JOUR T1 - Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma AN - 20724372; 7933525 AB - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. JF - Carcinogenesis AU - Brenner, A V AU - Butler, MA AU - Wang, S S AU - Ruder, A M AU - Rothman, N AU - Schulte, P A AU - Chanock, S J AU - Fine, HA AU - Linet AU - Inskip, P D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA. Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2543 EP - 2547 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 12 SN - 0143-3334, 0143-3334 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Historical account KW - Interleukin 4 KW - Etiology KW - Occupational safety KW - Autoimmune diseases KW - autoimmune diseases KW - Population studies KW - Allergies KW - Cancer KW - Brain tumors KW - glioma KW - Hypersensitivity KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - Cytokines KW - Glioma KW - G 07720:Immunogenetics KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health KW - N 14845:Miscellaneous KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Single-nucleotide+polymorphisms+in+selected+cytokine+genes+and+risk+of+adult+glioma&rft.au=Brenner%2C+A+V%3BButler%2C+MA%3BWang%2C+S+S%3BRuder%2C+A+M%3BRothman%2C+N%3BSchulte%2C+P+A%3BChanock%2C+S+J%3BFine%2C+HA%3BLinet%3BInskip%2C+P+D&rft.aulast=Brenner&rft.aufirst=A&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Brain tumors; Etiology; Hypersensitivity; Interleukin 4; Single-nucleotide polymorphism; Autoimmune diseases; Carcinogenesis; Population studies; Cytokines; Glioma; Historical account; glioma; Occupational safety; autoimmune diseases; Allergies; Cancer ER - TY - JOUR T1 - beta -Ionone reactions with ozone and OH radical: Rate constants and gas-phase products AN - 20692308; 8182568 AB - The bimolecular rate constants, k sub(O) sub(H) sub(?) sub(+) sub( beta ) sub(-) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e) (118+/-30)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) and k sub(O) sub(3) sub(+) sub( beta ) sub( approximately equal to ) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e), (0.19+ /-0.05)x10 super(-) super(1) super(6)cm super(3)molecule super(-) super(1)s super(-) super(1), were measured using the relative rate technique for the reaction of the hydroxyl radical (OH) and ozone (O sub(3)) with 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one ( beta -ionone) at 297+/-3K and 1atm total pressure. To more clearly define part of beta -ionone's indoor environment degradation mechanism, the products of the beta -ionone+OH? and beta -ionone+O sub(3) reactions were also investigated. The identified beta -ionone+OH? reaction products were: glyoxal (ethanedial, HC(=O)C(=O)H), and methylglyoxal (2-oxopropanal, CH sub(3)C(=O)C(=O)H) and the identified beta -ionone+O sub(3) reaction product was 2-oxopropanal. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) were used to propose 2,6,6-trimethylcyclohex-1-ene-1-carbaldehyde as the other major beta -ionone+OH? and beta -ionone+O sub(3) reaction product. The elucidation of this other reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible beta -ionone+OH? and beta -ionone+O sub(3) reaction mechanisms based on previously published volatile organic compound+OH? and volatile organic compound+O sub(3) gas-phase reaction mechanisms. The additional gas-phase products observed from the beta -ionone+OH? reaction are proposed to be the result of cyclization through a radical intermediate. JF - Atmospheric Environment AU - Forester, C D AU - Ham, JE AU - Wells, J R AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ozw0@cdc.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 8758 EP - 8771 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 38 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone measurements KW - Mass spectrometry KW - Hydroxyl radicals KW - Hydroxyl photochemistry KW - Indoor environments KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20692308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=beta+-Ionone+reactions+with+ozone+and+OH+radical%3A+Rate+constants+and+gas-phase+products&rft.au=Forester%2C+C+D%3BHam%2C+JE%3BWells%2C+J+R&rft.aulast=Forester&rft.aufirst=C&rft.date=2007-12-01&rft.volume=41&rft.issue=38&rft.spage=8758&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2007.07.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Indoor environments; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.atmosenv.2007.07.047 ER - TY - JOUR T1 - Overview of monoclonal B-cell lymphocytosis AN - 20588748; 7978368 AB - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL. JF - British Journal of Haematology AU - Marti, Gerald AU - Abbasi, Fatima AU - Raveche, Elizabeth AU - Rawstron, Andy C AU - Ghia, Paolo AU - Aurran, Therese AU - Caporaso, Neil AU - Shim, Youn K AU - Vogt, Robert F AD - Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, gemarti@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 701 EP - 708 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 139 IS - 5 SN - 0007-1048, 0007-1048 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - chronic lymphocytic leukaemia KW - monoclonal B-cell lymphocytosis KW - Lymphocytes B KW - Aging KW - Environmental health KW - Population studies KW - Toxins KW - population studies KW - Leukemia KW - Lymphocytosis KW - Differential diagnosis KW - Reviews KW - senescence KW - Geriatrics KW - Senescence KW - elderly KW - Chronic lymphatic leukemia KW - F 06915:Cancer Immunology KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Overview+of+monoclonal+B-cell+lymphocytosis&rft.au=Marti%2C+Gerald%3BAbbasi%2C+Fatima%3BRaveche%2C+Elizabeth%3BRawstron%2C+Andy+C%3BGhia%2C+Paolo%3BAurran%2C+Therese%3BCaporaso%2C+Neil%3BShim%2C+Youn+K%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2007.06865.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differential diagnosis; Lymphocytosis; Lymphocytes B; Reviews; Aging; Geriatrics; Population studies; Senescence; Chronic lymphatic leukemia; Toxins; population studies; Leukemia; senescence; Environmental health; elderly DO - http://dx.doi.org/10.1111/j.1365-2141.2007.06865.x ER - TY - JOUR T1 - Gastroenteritis Outbreak Caused by Waterborne Norovirus at a New Zealand Ski Resort AN - 20552086; 7932127 AB - In July 2006, public health services investigated an outbreak of acute gastroenteritis among staff and visitors of a popular ski resort in southern New Zealand. The source of the outbreak was a drinking water supply contaminated by human sewage. The virological component of the investigation played a major role in confirming the source of the outbreak. Drinking water, source stream water, and 31 fecal specimens from gastroenteritis outbreak cases were analyzed for the presence of norovirus (NoV). Water samples were concentrated by ultrafiltration, and real-time reverse transcription-PCR (RT-PCR) was used for rapid detection of NoV from both water and fecal samples. The implicated NoV strain was further characterized by DNA sequencing. NoV genogroup GI/5 was identified in water samples and linked case fecal specimens, providing clear evidence of the predominant pathogen and route of exposure. A retrospective cohort study demonstrated that staff who consumed drinking water from the resort supply were twice as likely to have gastroenteritis than those who did not. This is the first time that an outbreak of gastroenteritis in New Zealand has been conclusively linked to NoV detected in a community water supply. To our knowledge, this is the first report of the use of ultrafiltration combined with quantitative real-time RT-PCR and DNA sequencing for investigation of a waterborne NoV outbreak. JF - Applied and Environmental Microbiology AU - Hewitt, Joanne AU - Bell, Derek AU - Simmons, Greg C AU - Rivera-Aban, Malet AU - Wolf, Sandro AU - Greening, Gail E AD - Communicable Disease Group, Institute of Environmental Science & Research Ltd., Kenepuru Science Centre, P.O. Box 50-348, Porirua, New Zealand. Public Health South, P.O. Box 2180, Queenstown, New Zealand. Auckland Regional Public Health Service, Private Bag 92605, Auckland, New Zealand Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 7853 EP - 7857 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 24 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Ultrafiltration KW - Norovirus KW - Pathogens KW - Streams KW - Water supplies KW - Ski protein KW - Public health KW - DNA sequencing KW - Sewage KW - Polymerase chain reaction KW - Gastroenteritis KW - Drinking water KW - V 22490:Miscellaneous KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Gastroenteritis+Outbreak+Caused+by+Waterborne+Norovirus+at+a+New+Zealand+Ski+Resort&rft.au=Hewitt%2C+Joanne%3BBell%2C+Derek%3BSimmons%2C+Greg+C%3BRivera-Aban%2C+Malet%3BWolf%2C+Sandro%3BGreening%2C+Gail+E&rft.aulast=Hewitt&rft.aufirst=Joanne&rft.date=2007-12-01&rft.volume=73&rft.issue=24&rft.spage=7853&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ultrafiltration; DNA sequencing; Sewage; Polymerase chain reaction; Pathogens; Drinking water; Gastroenteritis; Water supplies; Streams; Public health; Ski protein; Norovirus ER - TY - JOUR T1 - Serious Psychological Distress Among Parenting and Nonparenting Adults AN - 20522255; 7928565 AB - OBJECTIVES: We compared the prevalence of serious psychological distress among parenting adults with the prevalence among nonparenting adults and the sociodemographic correlates of serious psychological distress between these 2 populations. METHODS: We drew data from 14240 parenting adults and 19224 nonparenting adults who responded to the 2002 National Survey on Drug Use and Health. We used logistic regression procedures in our analysis. RESULTS: An estimated 8.9% of parenting adults had serious psychological distress in the prior year compared with 12.0% of nonparenting adults of similar age. In both groups, the adjusted odds of having serious psychological distress were higher among adults who were women, younger (between the ages of 18 and 44 years), low income, or receiving Medicaid. We found some differences in the correlates of serious psychological distress between parenting adults and nonparenting adults. The odds of having serious psychological distress were lower among parenting adults after we controlled for demographic characteristics. CONCLUSIONS: Serious psychological distress is fairly prevalent among parenting adults, and high-risk sociodemographic groups of parenting adults should be targeted to ensure access to coordination of services. JF - American Journal of Public Health AU - Herman-Stahl, Mindy AU - Ashley, Olivia Silber AU - Penne, Michael A AU - Bauman, Karl E AU - Weitzenkamp, David AU - Aldridge, Molly AU - Gfroerer, Joseph C AD - Mindy Herman-Stahl, Olivia Silber Ashley, Michael A. Penne, Karl E. Bauman, and David Weitzenkamp are with RTI International, Research Triangle Park, NC. At the time of the study, Molly Aldridge was with RTI International, Research Triangle Park, NC. Joseph C. Gfroerer is with the Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2222 EP - 2229 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Serious+Psychological+Distress+Among+Parenting+and+Nonparenting+Adults&rft.au=Herman-Stahl%2C+Mindy%3BAshley%2C+Olivia+Silber%3BPenne%2C+Michael+A%3BBauman%2C+Karl+E%3BWeitzenkamp%2C+David%3BAldridge%2C+Molly%3BGfroerer%2C+Joseph+C&rft.aulast=Herman-Stahl&rft.aufirst=Mindy&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2222&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Association of Smoking Cessation With Financial Stress and Material Well-Being: Results From a Prospective Study of a Population-Based National Survey AN - 20521906; 7928573 AB - OBJECTIVES: We used 4 waves of prospective data to examine the association of smoking cessation with financial stress and material well-being. METHODS: Data (n = 5699 at baseline) came from 4 consecutive waves (2001-2005) of the Household Income and Labour Dynamics in Australia survey. We used mixed models to examine the participant-specific association of smoking cessation with financial stress and material well-being. RESULTS: On average, a smoker who quits is expected to have a 25% reduction (P<.001; odds ratio [OR]=0.75; 95% confidence interaval [CI]=0.69, 0.81) in the odds of financial stress. Similarly, the data provided strong evidence (P<.001) that a smoker who quits is likely to experience an enhanced level of material well-being. CONCLUSIONS: Our findings indicate that interventions to encourage smoking cessation are likely to improve standards of living and reduce deprivation. The findings provide grounds for encouraging the social services sector to incorporate smoking cessation efforts into their programs to enhance the material or financial conditions of disadvantaged groups. The findings also provide additional incentives for smokers to stop smoking and as such can be used in antismoking campaigns and by smoking cessation services. JF - American Journal of Public Health AU - Siahpush, Mohammad AU - Spittal, Matt AU - Singh, Gopal K AD - At the time of this study, Mohammad Siahpush and Matt Spittal were with the Centre for Behavioural Research in Cancer, Cancer Council Victoria, Victoria, Australia. Gopal K. Singh is with the Maternal and Child Health Bureau, Health Resources and Service Administration, Rockville, Md Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2281 EP - 2287 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Association+of+Smoking+Cessation+With+Financial+Stress+and+Material+Well-Being%3A+Results+From+a+Prospective+Study+of+a+Population-Based+National+Survey&rft.au=Siahpush%2C+Mohammad%3BSpittal%2C+Matt%3BSingh%2C+Gopal+K&rft.aulast=Siahpush&rft.aufirst=Mohammad&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2281&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance-linked ATP binding cassette drug transporter ABCG2 AN - 20472676; 7936730 AB - Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance-linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [ super(125)I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC sub(50) values of 7.3 and 22.6 mu mol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. [Mol Cancer Ther 2007; 6(12):3279-86] JF - Molecular Cancer Therapeutics AU - Shukla, Suneet AU - Wu, Chung-Pu AU - Nandigama, Krishnamachary AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3279 EP - 3286 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Adenosinetriphosphatase KW - Apoptosis KW - ATP KW - Hydrolysis KW - Cancer KW - Blood coagulation KW - Stem cells KW - Cytotoxicity KW - Vitamins KW - Carcinogenesis KW - Menadione KW - Hemopoiesis KW - Plumbagin KW - Radioresistance KW - rhodamine KW - mitoxantrone KW - Drugs KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20472676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=The+naphthoquinones%2C+vitamin+K3+and+its+structural+analogue+plumbagin%2C+are+substrates+of+the+multidrug+resistance-linked+ATP+binding+cassette+drug+transporter+ABCG2&rft.au=Shukla%2C+Suneet%3BWu%2C+Chung-Pu%3BNandigama%2C+Krishnamachary%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3279&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Adenosinetriphosphatase; ATP; Hydrolysis; Cancer; Cytotoxicity; Stem cells; Blood coagulation; Vitamins; Carcinogenesis; Menadione; Plumbagin; Hemopoiesis; Radioresistance; Drugs; mitoxantrone; rhodamine ER - TY - JOUR T1 - Assessment of Child and Adolescent Overweight and Obesity AN - 20375804; 7745308 AB - Accurate appropriate assessment of overweight and obesity in children and adolescents is a critical aspect of contemporary medical care. However, physicians and other health care professionals may find this a somewhat thorny field to enter. The BMI has become the standard as a reliable indicator of overweight and obesity. The BMI is incomplete, however, without consideration of the complex behavioral factors that influence obesity.Because of limited time and resources, clinicians need to have quick, evidence-based interventions that can help patients and their families recognize the importance of reducing overweight and obesity and take action. In an era of fast food, computers, and DVDs, it is not easy to persuade patients to modify their diets and to become more physically active. Because research concerning effective assessment of childhood obesity contains many gaps, this report is intended to provide a comprehensive approach to assessment and to present the evidence available to support key aspects of assessment. The discussion and recommendations are based on >300 studies published since 1995, which examined an array of assessment tools. With this information, clinicians should find themselves better equipped to face the challenges of assessing childhood overweight and obesity accurately. JF - Pediatrics AU - Krebs, Nancy F AU - Himes, John H AU - Jacobson, Dawn AU - Nicklas, Theresa A AU - Guilday, Patricia AU - Styne, Dennis AD - Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota. Office of Disease Prevention and Health Promotion, Department of Health and Human Services, Rockville, Maryland. Department of Pediatrics, Baylor College of Medicine, Houston, Texas. PS duPont Elementary School, Wilmington, Delaware. Department of Pediatrics, University of California, Davis, Sacramento, California Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - S193 EP - S228 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 120 SN - 0031-4005, 0031-4005 KW - Physical Education Index KW - Obesity KW - Health (care) KW - Diet (effects) KW - Pediatrics KW - Adolescence KW - Body mass KW - Computers KW - Patients KW - Children KW - Evaluation KW - Family KW - Physicians KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Assessment+of+Child+and+Adolescent+Overweight+and+Obesity&rft.au=Krebs%2C+Nancy+F%3BHimes%2C+John+H%3BJacobson%2C+Dawn%3BNicklas%2C+Theresa+A%3BGuilday%2C+Patricia%3BStyne%2C+Dennis&rft.aulast=Krebs&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=120&rft.issue=&rft.spage=S193&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Diet (effects); Health (care); Pediatrics; Computers; Body mass; Adolescence; Family; Physicians; Patients; Children ER - TY - JOUR T1 - AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor? AN - 20373139; 7741463 AB - A previous article on standardization of pharmacokinetic/pharmacodynamic terminology for anti-infective drugs recommended deletion of the units of the AUC/MIC ratio (actually h). We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresponding to the current index divided now by 24 h. This is the scaling factor without units by which the targeted MIC should be multiplied to estimate the average in vivo plasma concentration to be achieved. Associated with this proposal, we address the specific issue of veterinary drug products for which steady conditions are seldom achieved. To accommodate the need for dose prediction during these novel therapeutic situations, we propose a general approach that is based on the targeted time interval over which some desired average concentration should be maintained. JF - Journal of Antimicrobial Chemotherapy AU - Toutain, Pierre-Louis AU - Bousquet-Melou, Alain AU - Martinez, Marilyn AD - UMR181 Physiopathologie et Toxicologie Experimentales INRA, ENVT, 23 Chemin des Capelles, 31076 Toulouse cedex 03, France. FDA, Center for Veterinary Medicine, Rockville, MD, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1185 EP - 1188 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 6 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Standardization KW - Antibiotics KW - Minimum inhibitory concentration KW - Drugs KW - Pharmacokinetics KW - Pharmacodynamics KW - A 01350:Microbial Resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=AUC%2FMIC%3A+a+PK%2FPD+index+for+antibiotics+with+a+time+dimension+or+simply+a+dimensionless+scoring+factor%3F&rft.au=Toutain%2C+Pierre-Louis%3BBousquet-Melou%2C+Alain%3BMartinez%2C+Marilyn&rft.aulast=Toutain&rft.aufirst=Pierre-Louis&rft.date=2007-12-01&rft.volume=60&rft.issue=6&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standardization; Antibiotics; Drugs; Minimum inhibitory concentration; Pharmacodynamics; Pharmacokinetics ER - TY - JOUR T1 - Differential Requirements by CD4 super(+) and CD8 super(+) T Cells for Soluble and Membrane TNF in Control of Francisella tularensis Live Vaccine Strain Intramacrophage Growth AN - 20324339; 7743272 AB - During primary infection with intracellular bacteria, the membrane-associated form of TNF provides some TNF functions, but the relative contributions during memory responses are not well-characterized. In this study, we determined the role of T cell-derived secreted and membrane-bound TNF (memTNF) during adaptive immunity to Francisella tularensis live vaccine strain (LVS). Although transgenic mice expressing only the memTNF were more susceptible to primary LVS infection than wild-type (WT) mice, LVS-immune WT and memTNF mice both survived maximal lethal secondary Francisella challenge. Generation of CD44 super(high) memory T cells and clearance of bacteria were similar, although more IFN- gamma and IL-12(p40) were produced by memTNF mice. To examine T cell function, we used an in vitro tissue coculture system that measures control of LVS intramacrophage growth by LVS-immune WT and memTNF-T cells. LVS-immune CD4 super(+) and CD8 super(+) T cells isolated from WT and memTNF mice exhibited comparable control of LVS growth in either normal or TNF- alpha knockout macrophages. Although the magnitude of CD4 super(+) T cell-induced macrophage NO production clearly depended on TNF, control of LVS growth by both CD4 super(+) and CD8 super(+) T cells did not correlate with levels of nitrite. Importantly, intramacrophage LVS growth control by CD8 super(+) T cells, but not CD4 super(+) T cells, was almost entirely dependent on T cell-expressed TNF, and required stimulation through macrophage TNFRs. Collectively, these data demonstrate that T cell-expressed memTNF is necessary and sufficient for memory T cell responses to this intracellular pathogen, and is particularly important for intramacrophage control of bacterial growth by CD8 super(+) T cells. JF - Journal of Immunology AU - Cowley, Siobhan C AU - Sedgwick, Jonathon D AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, U.S. Food and Drug Administration, Rockville, MD 20852. Eli Lilly and Company, Indianapolis, IN 46285 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7709 EP - 7719 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 11 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - gamma -Interferon KW - Memory cells KW - Immunological memory KW - Francisella tularensis KW - Pathogens KW - CD8 antigen KW - Transgenic mice KW - Infection KW - Tumor necrosis factor receptors KW - CD4 antigen KW - Lymphocytes T KW - Nitric oxide KW - Tumor necrosis factor- alpha KW - Vaccines KW - Nitrite KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20324339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Differential+Requirements+by+CD4+super%28%2B%29+and+CD8+super%28%2B%29+T+Cells+for+Soluble+and+Membrane+TNF+in+Control+of+Francisella+tularensis+Live+Vaccine+Strain+Intramacrophage+Growth&rft.au=Cowley%2C+Siobhan+C%3BSedgwick%2C+Jonathon+D%3BElkins%2C+Karen+L&rft.aulast=Cowley&rft.aufirst=Siobhan&rft.date=2007-12-01&rft.volume=179&rft.issue=11&rft.spage=7709&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Immunological memory; Memory cells; CD8 antigen; Pathogens; Infection; Transgenic mice; Tumor necrosis factor receptors; CD4 antigen; Lymphocytes T; Nitric oxide; Vaccines; Tumor necrosis factor- alpha; Nitrite; Francisella tularensis ER - TY - JOUR T1 - Characteristics of Dusts Encountered during the Production of Cemented Tungsten Carbides AN - 20234850; 8044994 AB - Inhalation of cobalt (Co) and tungsten carbide (WC) particles, but not Co or WC alone, may cause hard metal disease, risk of which does not appear to be uniform across cemented tungsten carbide (CTC) production processes. Inhalation of Co alone or in the presence of WC may cause asthma. Hypothesizing that aerosol size, chemical content, heterogeneity, and constituent compaction may be important exposure factors, we characterized aerosols from representative CTC manufacturing processes. Six work areas were sampled to characterize aerosol size distributions (dust, Co) and 12 work areas were sampled to characterize physicochemical properties (using scanning electron microscopy with energy dispersive x-ray spectrometry [SEMEDX]). Bulk feedstock and process-generated powders were characterized with SEM-EDX and x-ray diffraction. The dust mass median diameter was respirable and the cobalt respirable mass fraction was highest (37%) in grinding. Morphology of particles changed with processing: individual, agglomerate, or aggregates (pre-sintered materials), then mostly compacted particles (subsequent to sintering). Elemental composition of particles became increasingly heterogeneous: mostly discrete Co or W particles (prior to spray drying), then heterogeneous W/Co particles (subsequent work areas). Variability in aerosol respirability and chemical heterogeneity could translate into differences in toxicity and support detailed characterization of physicochemical properties during exposure assessments. JF - Industrial Health AU - Stefaniak, AB AU - Day, G A AU - Harvey, C J AU - Leonard, S S AU - Schwegler-Berry, DE AU - Chipera, S J AU - Sahakian, N M AU - Chisholm, W P AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 793 EP - 803 VL - 45 IS - 6 SN - 0019-8366, 0019-8366 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Respiratory diseases KW - Chemical composition KW - Microscopy KW - Dust KW - Cobalt KW - Sprays KW - Physicochemical properties KW - Toxicity KW - Morphology KW - Aerosols KW - Asthma KW - Inhalation KW - Particulates KW - Tungsten KW - Occupational exposure KW - Spectrometry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Characteristics+of+Dusts+Encountered+during+the+Production+of+Cemented+Tungsten+Carbides&rft.au=Stefaniak%2C+AB%3BDay%2C+G+A%3BHarvey%2C+C+J%3BLeonard%2C+S+S%3BSchwegler-Berry%2C+DE%3BChipera%2C+S+J%3BSahakian%2C+N+M%3BChisholm%2C+W+P&rft.aulast=Stefaniak&rft.aufirst=AB&rft.date=2007-12-01&rft.volume=45&rft.issue=6&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Particulates; Toxicity; Aerosols; Tungsten; Dust; Physicochemical properties; Cobalt; Inhalation; Asthma; Morphology; Microscopy; Respiratory diseases; Sprays; Occupational exposure; Spectrometry; Chemical composition ER - TY - JOUR T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes III. An Efficient Method of Monitoring Chromosomal Damage in the Beagle Dog AN - 20046077; 7746661 AB - Erythrocyte-based micronucleus tests have traditionally analyzed bone marrow because splenic filtration in most species removes micronucleated cells from peripheral blood. We have evaluated a flow cytometric method for monitoring micronucleated reticulocyte frequencies (%MN-RET) in the peripheral blood of beagle dogs treated with cyclophosphamide (CP) and have found that analysis of micronucleated reticulocytes (MN-RETs) in peripheral blood is a suitable surrogate for bone marrow analysis. The three-color flow cytometric method uses anti-CD71 labeling to identify reticulocytes and Plasmodium berghei-containing erythrocytes as a calibration standard. The spontaneous %MN-RET determined by flow cytometry was 0.31 plus or minus 0.09% (n = 22) for peripheral blood, compared with 0.38 plus or minus 0.13% (SD, n = 12) for bone marrow, and 0.27 plus or minus 0.08% (n = 12) for peripheral blood by microscopic scoring with acridine orange staining. The kinetics of appearance and disappearance of MN-RETs in blood were determined by collecting daily samples after iv treatment with CP. The maximum frequency occurred similar to 48 h after dosing. Frequencies of MN-RETs in peripheral blood at steady state following daily CP treatment were 55-68% of corresponding bone marrow values assessed by microscopy and 55-112% as assessed by flow cytometry. This difference is presumably due to splenic removal, which appears slightly less stringent than that previously reported for CP-treated Sprague-Dawley rats. Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses. JF - Toxicological Sciences AU - Harper, Susan B AU - Dertinger, Stephen D AU - Bishop, Michelle E AU - Lynch, Anthony M AU - Lorenzo, Maria AU - Saylor, Michelle AU - MacGregor, James T AD - Department of Veterans Affairs, Washington, DC 20422. Litron Laboratories, Rochester, NY 14623. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079. GlaxoSmithKline Research & Development, Herts, SG12 0DP, UK. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD 20708. Toxicology Consulting Services, Arnold, MD 21012 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 406 EP - 414 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Acridine orange KW - Micronuclei KW - Erythrocytes KW - Bone marrow KW - Spleen KW - Peripheral blood KW - Cyclophosphamide KW - Flow cytometry KW - Plasmodium KW - Filtration KW - Kinetics KW - Microscopy KW - Reticulocytes KW - K 03410:Animal Diseases KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20046077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Flow+Cytometric+Analysis+of+Micronuclei+in+Peripheral+Blood+Reticulocytes+III.+An+Efficient+Method+of+Monitoring+Chromosomal+Damage+in+the+Beagle+Dog&rft.au=Harper%2C+Susan+B%3BDertinger%2C+Stephen+D%3BBishop%2C+Michelle+E%3BLynch%2C+Anthony+M%3BLorenzo%2C+Maria%3BSaylor%2C+Michelle%3BMacGregor%2C+James+T&rft.aulast=Harper&rft.aufirst=Susan&rft.date=2007-12-01&rft.volume=100&rft.issue=2&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Acridine orange; Flow cytometry; Filtration; Kinetics; Microscopy; Erythrocytes; Micronuclei; Bone marrow; Spleen; Peripheral blood; Cyclophosphamide; Reticulocytes; Plasmodium ER - TY - JOUR T1 - Antimicrobial Susceptibility and Distribution of Antimicrobial-Resistance Genes Among Enterococcus and Coagulase-Negative Staphylococcus Isolates Recovered from Poultry Litter AN - 20036938; 8691868 AB - Data on the prevalence of antimicrobial resistant enterococci and staphylococci from the poultry production environment are sparse in the United States. This information is needed for science-based risk assessments of antimicrobial use in animal husbandry and potential public-health consequences. In this study, we assessed the susceptibility of staphylococci and enterococci isolated from poultry litter, recovered from 24 farms across Georgia, to several antimicrobials of veterinary and human health importance. Among the 90 Enterococcus isolates recovered, E. hirae (46%) was the most frequently encountered species, followed by E. faecium (27%), E. gallinarum (12%), and E. faecalis (10%). Antimicrobial resistance was most often observed to tetracycline (96%), followed by clindamycin (90%), quinupristin-dalfopristin (62%), penicillin (53%), erythromycin (50%), nitrofurantoin (49%), and clarithromycin (48%). Among the 110 staphylococci isolates recovered, only coagulase-negative staphylococci (CNS) were identified with the predominant Staphylococcus species being S. sciuri (38%), S. lentus (21%), S. xylosus (14%) and S. simulans (12%). Resistance was less-frequently observed among the Staphylococcus isolates for the majority of antimicrobials tested, as compared with Enterococcus isolates, and was primarily limited to clarithromycin (71%), erythromycin (71%), clindamycin (48%), and tetracycline (38%). Multidrug resistance (MDR) phenotypes were prevalent in both Enterococcus and Staphylococcus; however, Enterococcus exhibited a statistically significant difference in the median number of antimicrobials to which resistance was observed (median = 5.0) compared with Staphylococcus species (median = 3.0). Because resistance to several of these antimicrobials in gram-positive bacteria may be attributed to the shuttling of common drug-resistance genes, we also determined which common antimicrobial-resistance genes were present in both enterococci and staphylococci. The antimicrobial resistance genes vat(D) and erm(B) were present in enterococci, vgaB in staphylococci, and mobile genetic elements Tn916 and pheromone-inducible plasmids were only identified in enterococci. These data suggest that the disparity in antimicrobial-resistance phenotypes and genotypes between enterococci and staphylococci isolated from the same environment is, in part, because of barriers preventing exchange of mobile DNA elements. JF - Avian Diseases AU - Simjee, Shabbir AU - McDermott, Patrick F AU - White, David G AU - Hofacre, Charles AU - Berghaus, Roy D AU - Carter, Peggy J AU - Stewart, Leigh AU - Liu, Tongrui AU - Maier, Marie AU - Maurer, John J AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, jmaurer@vet.uga.edu Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 884 EP - 892 PB - American Association of Avian Pathologists, Inc., 382 West Street Road VL - 51 IS - 4 SN - 0005-2086, 0005-2086 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - antimicrobial resistance KW - poultry KW - enterococci KW - staphylococci KW - vat(D) KW - erm(B) KW - Risk assessment KW - Central nervous system KW - Clindamycin KW - Litter KW - Poultry KW - Data processing KW - Farms KW - Gram-positive bacteria KW - Drug resistance KW - Staphylococcus KW - quinupristin-dalfopristin KW - Statistical analysis KW - Genotypes KW - Plasmids KW - Erythromycin KW - Tetracyclines KW - Penicillin KW - Clarithromycin KW - Nitrofurantoin KW - Enterococcus KW - Multidrug resistance KW - Husbandry KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20036938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Avian+Diseases&rft.atitle=Antimicrobial+Susceptibility+and+Distribution+of+Antimicrobial-Resistance+Genes+Among+Enterococcus+and+Coagulase-Negative+Staphylococcus+Isolates+Recovered+from+Poultry+Litter&rft.au=Simjee%2C+Shabbir%3BMcDermott%2C+Patrick+F%3BWhite%2C+David+G%3BHofacre%2C+Charles%3BBerghaus%2C+Roy+D%3BCarter%2C+Peggy+J%3BStewart%2C+Leigh%3BLiu%2C+Tongrui%3BMaier%2C+Marie%3BMaurer%2C+John+J&rft.aulast=Simjee&rft.aufirst=Shabbir&rft.date=2007-12-01&rft.volume=51&rft.issue=4&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Avian+Diseases&rft.issn=00052086&rft_id=info:doi/10.1637%2F7973-032607-REGR.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Central nervous system; Poultry; Litter; Clindamycin; Farms; Data processing; Drug resistance; Gram-positive bacteria; quinupristin-dalfopristin; Statistical analysis; Genotypes; Tetracyclines; Erythromycin; Plasmids; Penicillin; Clarithromycin; Nitrofurantoin; Multidrug resistance; Husbandry; Staphylococcus; Enterococcus DO - http://dx.doi.org/10.1637/7973-032607-REGR.1 ER - TY - JOUR T1 - Variability of Total and Pathogenic Vibrio parahaemolyticus Densities in Northern Gulf of Mexico Water and Oysters AN - 19993264; 7928254 AB - Vibrio parahaemolyticus is indigenous to coastal environments and a frequent cause of seafood-borne gastroenteritis in the United States, primarily due to raw-oyster consumption. Previous seasonal-cycle studies of V. parahaemolyticus have identified water temperature as the strongest environmental predictor. Salinity has also been identified, although it is evident that its effect on annual variation is not as pronounced. The effects of other environmental factors, both with respect to the seasonal cycle and intraseasonal variation, are uncertain. This study investigated intraseasonal variations of densities of total and pathogenic V. parahaemolyticus organisms in oysters and overlying waters during the summer of 2004 at two sites in the northern Gulf of Mexico. Regression analyses indicated significant associations (P < 0.001) between total V. parahaemolyticus densities and salinity, as well as turbidity in water and in oysters at the Mississippi site but not at the Alabama site. Pathogenic V. parahaemolyticus organisms in Mississippi oyster and water samples were detected in 56% (9 out of 16) and 78% (43 out of 55) of samples, respectively. In contrast, 44% (7 out of 16) of oyster samples and 30% (14 out of 47) of water samples from Alabama were positive. At both sites, there was greater sample-to-sample variability in pathogenic V. parahaemolyticus densities than in total V. parahaemolyticus densities. These data suggest that, although total V. parahaemolyticus densities may be very informative, there is greater uncertainty when total V. parahaemolyticus densities are used to predict the risk of infection by pathogenic V. parahaemolyticus than previously recognized. JF - Applied and Environmental Microbiology AU - Zimmerman, A M AU - DePaola, A AU - Bowers, J C AU - Krantz, JA AU - Nordstrom, J L AU - Johnson, C N AU - Grimes, D J AD - University of Southern Mississippi, Gulf Coast Research Laboratory, Ocean Springs, Mississippi. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama. Food and Drug Administration, College Park, Maryland Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7589 EP - 7596 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 73 IS - 23 SN - 0099-2240, 0099-2240 KW - Ecology Abstracts; Aqualine Abstracts; Pollution Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts A: Industrial & Applied Microbiology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - ASW, USA, Alabama KW - Coastal environments KW - Water Sampling KW - Gulfs KW - Public health KW - Salinity KW - Vibrio parahaemolyticus KW - Seasonal variations KW - environmental factors KW - annual variations KW - Pathogenic bacteria KW - Water temperature KW - Vibrio KW - Coastal zone KW - Oysters KW - Marine molluscs KW - Turbidity KW - Variability KW - Geographical distribution KW - Water sampling KW - Water Analysis KW - Infection KW - Environmental factors KW - Sulfur dioxide KW - oysters KW - Salinity effects KW - infection KW - Regression analysis KW - Marine KW - Data processing KW - Annual variations KW - Density KW - ASW, Mexico Gulf KW - ASW, USA, Mississippi KW - gastroenteritis KW - Water wells KW - summer KW - Gastroenteritis KW - water temperature KW - AQ 00001:Water Resources and Supplies KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - SW 0810:General KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - P 1000:MARINE POLLUTION KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Variability+of+Total+and+Pathogenic+Vibrio+parahaemolyticus+Densities+in+Northern+Gulf+of+Mexico+Water+and+Oysters&rft.au=Zimmerman%2C+A+M%3BDePaola%2C+A%3BBowers%2C+J+C%3BKrantz%2C+JA%3BNordstrom%2C+J+L%3BJohnson%2C+C+N%3BGrimes%2C+D+J&rft.aulast=Zimmerman&rft.aufirst=A&rft.date=2007-12-01&rft.volume=73&rft.issue=23&rft.spage=7589&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Coastal zone; Geographical distribution; Pathogenic bacteria; Annual variations; Marine molluscs; Seasonal variations; Turbidity; Public health; Data processing; Coastal environments; Salinity effects; Regression analysis; Water temperature; Gastroenteritis; Infection; Environmental factors; environmental factors; Water sampling; annual variations; Salinity; oysters; Sulfur dioxide; gastroenteritis; infection; summer; Water wells; water temperature; Variability; Vibrio; Water Analysis; Oysters; Density; Water Sampling; Gulfs; Vibrio parahaemolyticus; ASW, Mexico Gulf; ASW, USA, Mississippi; ASW, USA, Alabama; Marine ER - TY - JOUR T1 - Genome Sequence Analysis of the Emerging Human Pathogenic Acetic Acid Bacterium Granulibacter bethesdensis AN - 19900078; 7741959 AB - Chronic granulomatous disease (CGD) is an inherited immune deficiency characterized by increased susceptibility to infection with Staphylococcus, certain gram-negative bacteria, and fungi. Granulibacter bethesdensis, a newly described genus and species within the family Acetobacteraceae, was recently isolated from four CGD patients residing in geographically distinct locales who presented with fever and lymphadenitis. We sequenced the genome of the reference strain of Granulibacter bethesdensis, which was isolated from lymph nodes of the original patient. The genome contains 2,708,355 base pairs in a single circular chromosome, in which 2,437 putative open reading frames (ORFs) were identified, 1,470 of which share sequence similarity with ORFs in the nonpathogenic but related Gluconobacter oxydans genome. Included in the 967 ORFs that are unique to G. bethesdensis are ORFs potentially important for virulence, adherence, DNA uptake, and methanol utilization. GC% values and best BLAST analysis suggested that some of these unique ORFs were recently acquired. Comparison of G. bethesdensis to other known CGD pathogens demonstrated conservation of some putative virulence factors, suggesting possible common mechanisms involved in pathogenesis in CGD. Genotyping of the four patient isolates by use of a custom microarray demonstrated genome-wide variations in regions encoding DNA uptake systems and transcriptional regulators and in hypothetical ORFs. G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms. JF - Journal of Bacteriology AU - Greenberg, David E AU - Porcella, Stephen F AU - Zelazny, Adrian M AU - Virtaneva, Kimmo AU - Sturdevant, Dan E AU - Kupko, John JIII AU - Barbian, Kent D AU - Babar, Amenah AU - Dorward, David W AU - Holland, Steven M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840. Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8727 EP - 8736 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - virulence factors KW - Genotyping KW - Nucleotide sequence KW - Fungi KW - Staphylococcus KW - Methanol KW - Transcription KW - Gluconobacter oxydans KW - Pathogens KW - DNA microarrays KW - Acetic acid KW - Lymph nodes KW - Fever KW - Guanylate cyclase KW - Lymphadenitis KW - Gram-negative bacteria KW - Chronic infection KW - DNA KW - Conservation KW - Chronic granulomatous disease KW - Open reading frames KW - J 02400:Human Diseases KW - N 14810:Methods KW - G 07770:Bacteria KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genome+Sequence+Analysis+of+the+Emerging+Human+Pathogenic+Acetic+Acid+Bacterium+Granulibacter+bethesdensis&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BZelazny%2C+Adrian+M%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Dan+E%3BKupko%2C+John+JIII%3BBarbian%2C+Kent+D%3BBabar%2C+Amenah%3BDorward%2C+David+W%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; virulence factors; Fungi; Nucleotide sequence; Genotyping; Methanol; Transcription; Pathogens; Acetic acid; DNA microarrays; Lymph nodes; Fever; Guanylate cyclase; Lymphadenitis; Gram-negative bacteria; Chronic infection; DNA; Conservation; Chronic granulomatous disease; Open reading frames; Staphylococcus; Gluconobacter oxydans ER - TY - JOUR T1 - Short communication: Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems AN - 19539994; 8338366 AB - This cross-sectional study was conducted to determine the prevalence and antimicrobial resistance of Salmonella species in swine reared in the intensive (indoor) and extensive (outdoor) ABF production systems at farm and slaughter in North Carolina, U.S.A. We sampled a total of 279 pigs at farm (extensive 107; intensive 172) and collected 274 carcass swabs (extensive 124; intensive 150) at slaughter. Salmonella species were tested for their susceptibility against 12 antimicrobial agents using the Kirby-Bauer disk diffusion method. Serogrouping was done using polyvalent and group specific antisera. A total of 400 salmonellae were isolated in this study with a significantly higher Salmonella prevalence from the intensive (30%) than the extensive farms (0.9%) (P < 0.001). At slaughter, significantly higher Salmonella was isolated at the pre- and post-evisceration stages from extensively (29% pre-evisceration and 33.3% post-evisceration) than the intensively (2% pre-evisceration and 6% post-evisceration) reared swine (P < 0.001). The isolates were clustered in six serogroups including B, C, E1, E4, G and R. Highest frequency of antimicrobial resistance was observed against tetracycline (78.5%) and streptomycin (31.5%). A total of 13 antimicrobial resistance patterns were observed including the pentaresistant strains with ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline resistance pattern observed only among isolates from the intensive farms (n = 28) and all were serotype Salmonella typhimurium var. Copenhagen. In conclusion, this study shows that multidrug resistant Salmonella are prevalent in ABF production systems despite the absence of antimicrobial selection pressure. In addition, it also highlights the possible role played by slaughterhouse and other environmental factors in the contamination and dissemination of antimicrobial resistant Salmonella in ABF production systems. JF - Veterinary Microbiology AU - Thakur, Siddhartha AU - Tadesse, Daniel A AU - Morrow, Morgan AU - Gebreyes, Wondwossen A AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, United States, gebreyes.1@osu.edu Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 362 EP - 367 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 125 IS - 3-4 SN - 0378-1135, 0378-1135 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Swine KW - Salmonella species KW - Antimicrobial-free production system KW - Antimicrobials KW - Multidrug resistance KW - Chloramphenicol KW - Serotypes KW - Farms KW - Sulfamethoxazole KW - Contamination KW - Drug resistance KW - Ampicillin KW - Streptomycin KW - Salmonella typhimurium KW - Tetracyclines KW - Environmental factors KW - Antimicrobial agents KW - Antisera KW - Carcasses KW - Diffusion KW - Slaughter KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Short+communication%3A+Occurrence+of+multidrug+resistant+Salmonella+in+antimicrobial-free+%28ABF%29+swine+production+systems&rft.au=Thakur%2C+Siddhartha%3BTadesse%2C+Daniel+A%3BMorrow%2C+Morgan%3BGebreyes%2C+Wondwossen+A&rft.aulast=Thakur&rft.aufirst=Siddhartha&rft.date=2007-12-01&rft.volume=125&rft.issue=3-4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2007.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chloramphenicol; Farms; Serotypes; Contamination; Sulfamethoxazole; Drug resistance; Ampicillin; Streptomycin; Tetracyclines; Environmental factors; Antimicrobial agents; Antisera; Carcasses; Slaughter; Diffusion; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.vetmic.2007.05.025 ER - TY - JOUR T1 - Electromagnetic compatibility of pacemakers and implantable cardiac defibrillators exposed to RFID readers AN - 20502502; 9196294 JF - International Journal of Radio Frequency Identification Technology and Applications AU - Seidman, Seth J AU - Ruggera, Paul S AU - Brockman, Randall G AU - Lewis, Brian AU - Shein, Mitchell J AD - Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993, USA. Y1 - 2007/11/25/ PY - 2007 DA - 2007 Nov 25 SP - 237 EP - 246 PB - Inderscience Publishers Ltd., PO Box 735 VL - 1 IS - 3 SN - 1745-3216, 1745-3216 KW - Biotechnology and Bioengineering Abstracts KW - COMPUTING JOURNALS KW - TECHNICAL JOURNALS KW - Communications and Mobile Technology KW - Information Systems and Technology KW - Materials and Manufacturing KW - Heart KW - Pacemakers KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20502502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.atitle=Electromagnetic+compatibility+of+pacemakers+and+implantable+cardiac+defibrillators+exposed+to+RFID+readers&rft.au=Seidman%2C+Seth+J%3BRuggera%2C+Paul+S%3BBrockman%2C+Randall+G%3BLewis%2C+Brian%3BShein%2C+Mitchell+J&rft.aulast=Seidman&rft.aufirst=Seth&rft.date=2007-11-25&rft.volume=1&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.issn=17453216&rft_id=info:doi/10.1504%2FIJRFITA.2007.015848 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Pacemakers DO - http://dx.doi.org/10.1504/IJRFITA.2007.015848 ER - TY - JOUR T1 - Brief communication: characteristics of spontaneous cases of tuberculosis associated with infliximab. AN - 68522532; 18025446 AB - A warning for tuberculosis was added to the approved labeling for infliximab in October 2001. To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Case series. Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. 130 patients with infliximab-associated tuberculosis. Clinical and laboratory data. The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n = 89), history of latent or active tuberculosis (n = 33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n = 25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab. Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab. JF - Annals of internal medicine AU - Raval, Angela AU - Akhavan-Toyserkani, Gita AU - Brinker, Allen AU - Avigan, Mark AD - U. S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 699 EP - 702 VL - 147 IS - 10 KW - Anti-Inflammatory Agents KW - 0 KW - Antibodies, Monoclonal KW - Infliximab KW - B72HH48FLU KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Aged KW - False Negative Reactions KW - Adverse Drug Reaction Reporting Systems KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Immunocompromised Host KW - Middle Aged KW - Adolescent KW - Tuberculin Test KW - Female KW - Male KW - Tuberculosis -- etiology KW - Anti-Inflammatory Agents -- adverse effects KW - Tuberculosis -- immunology KW - Tuberculosis -- diagnosis KW - Antibodies, Monoclonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+characteristics+of+spontaneous+cases+of+tuberculosis+associated+with+infliximab.&rft.au=Raval%2C+Angela%3BAkhavan-Toyserkani%2C+Gita%3BBrinker%2C+Allen%3BAvigan%2C+Mark&rft.aulast=Raval&rft.aufirst=Angela&rft.date=2007-11-20&rft.volume=147&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Elimination Plan of Measles in Canary Islands 2001-2005 T2 - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007) AN - 40754856; 4771715 JF - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007) AU - Rojas, A Garcia AU - Castellano, P Garcia AU - Herrera, M Trujillo AU - Romero, J Solis AU - Cruz, P Matute AU - Benitez, N Abadia AU - Santacruz, L Gonzalez AU - Gallo, D Nunez AU - Gonzalez, M.C. Perez AU - Capuz, B Lafarga Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 KW - Atlantic, Canary Is. KW - Islands KW - Measles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.atitle=Elimination+Plan+of+Measles+in+Canary+Islands+2001-2005&rft.au=Rojas%2C+A+Garcia%3BCastellano%2C+P+Garcia%3BHerrera%2C+M+Trujillo%3BRomero%2C+J+Solis%3BCruz%2C+P+Matute%3BBenitez%2C+N+Abadia%3BSantacruz%2C+L+Gonzalez%3BGallo%2C+D+Nunez%3BGonzalez%2C+M.C.+Perez%3BCapuz%2C+B+Lafarga&rft.aulast=Rojas&rft.aufirst=A&rft.date=2007-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/wspid2007/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis AN - 19898747; 7786582 AB - Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, which is a life-threatening fatty liver disease with a risk of progression to cirrhosis and hepatocellular carcinoma. In recent years, the high-throughput microarray technology for large-scale analysis of gene expression has become a powerful tool for increasing the understanding of the molecular mechanisms of carcinogenesis and for identifying new biomarkers with diagnostic and predictive values. In the present study, we used the high-throughput microarray technology to determine the gene expression profiles in the liver during early stages of tamoxifen-induced rat hepatocarcinogenesis. Female Fisher 344 rats were fed a 420 ppm tamoxifen containing diet for 12 or 24 weeks, and gene expression profiles were determined in liver of control and tamoxifen-exposed rats. The results indicate that early stages of tamoxifen-induced liver carcinogenesis are characterized by alterations in several major cellular pathways, specifically those involved in the tamoxifen metabolism, lipid metabolism, cell cycle signaling, and apoptosis/cell proliferation control. One of the most prominent changes during early stages of tamoxifen-induced hepatocarcinogenesis is dysregulation of signaling pathways in cell cycle progression from the G sub(1) to S phase, evidenced by the progressive and sustained increase in expression of the Pdgfc, Calb3, Ets1, and Ccnd1 genes accompanied by the elevated level of the PI3K, p-PI3K, Akt1/2, Akt3, and cyclin B, D1, and D3 proteins. The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen. JF - Toxicology and Applied Pharmacology AU - Pogribny, I P AU - Bagnyukova, T V AU - Tryndyak, V P AU - Muskhelishvili, L AU - Rodriguez-Juarez, R AU - Kovalchuk, O AU - Han, T AU - Fuscoe, J C AU - Ross, SA AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, AR 72079, USA, igor.pogribny@fda.hhs.gov Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 61 EP - 69 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 225 IS - 1 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Toxicology Abstracts KW - Diets KW - Transformation KW - Molecular modelling KW - Apoptosis KW - Cirrhosis KW - Ets-1 protein KW - Chemotherapy KW - Cell cycle KW - biomarkers KW - Tamoxifen KW - Lipid metabolism KW - Gene expression KW - Cyclin B KW - 1-Phosphatidylinositol 3-kinase KW - S phase KW - Carcinogenesis KW - Fatty liver KW - Breast cancer KW - AKT1 protein KW - Cell proliferation KW - Signal transduction KW - Hepatocellular carcinoma KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19898747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Gene+expression+profiling+reveals+underlying+molecular+mechanisms+of+the+early+stages+of+tamoxifen-induced+rat+hepatocarcinogenesis&rft.au=Pogribny%2C+I+P%3BBagnyukova%2C+T+V%3BTryndyak%2C+V+P%3BMuskhelishvili%2C+L%3BRodriguez-Juarez%2C+R%3BKovalchuk%2C+O%3BHan%2C+T%3BFuscoe%2C+J+C%3BRoss%2C+SA%3BBeland%2C+F+A&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2007-11-15&rft.volume=225&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Diets; Molecular modelling; Cirrhosis; Apoptosis; Ets-1 protein; Chemotherapy; Cell cycle; Tamoxifen; biomarkers; Lipid metabolism; Gene expression; 1-Phosphatidylinositol 3-kinase; Cyclin B; S phase; Carcinogenesis; AKT1 protein; Breast cancer; Fatty liver; Cell proliferation; Hepatocellular carcinoma; Signal transduction DO - http://dx.doi.org/10.1016/j.taap.2007.07.001 ER - TY - JOUR T1 - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. AN - 68509434; 18003845 AB - In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuated by inhibition of glutamate transmission in the ventral tegmental area and medial accumbens shell, components of the mesolimbic dopamine system. Here, we explored the role of dopamine of the accumbens in context-induced reinstatement by using the D1-family receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride]. Rats were trained to self-administer heroin for 12 d; drug infusions were paired with a discrete tone-light cue. Subsequently, the heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. When tested in the original drug self-administration context, systemic and medial or lateral accumbens shell SCH 23390 injections attenuated context-induced reinstatement of heroin seeking, whereas accumbens core SCH 23390 injections were ineffective. In contrast, core but not lateral or medial shell SCH 23390 injections attenuated discrete-cue-induced reinstatement in a nondrug context after extinction of lever presses without this cue. Results indicate that activation of medial and lateral accumbens shell D1-family dopamine receptors mediate context-induced reinstatement of heroin seeking and provide the first demonstration for a role of lateral shell dopamine in conditioned drug effects. Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bossert, Jennifer M AU - Poles, Gabriela C AU - Wihbey, Kristina A AU - Koya, Eisuke AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12655 EP - 12663 VL - 27 IS - 46 KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine D1 KW - Index Medicus KW - Animals KW - Benzazepines -- pharmacology KW - Rats, Long-Evans KW - Disease Models, Animal KW - Extinction, Psychological -- physiology KW - Conditioning (Psychology) -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Conditioning (Psychology) -- physiology KW - Cues KW - Behavior, Animal -- physiology KW - Benzazepines -- therapeutic use KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Male KW - Reward KW - Heroin Dependence -- metabolism KW - Dopamine Antagonists -- therapeutic use KW - Nucleus Accumbens -- drug effects KW - Receptors, Dopamine D1 -- antagonists & inhibitors KW - Heroin Dependence -- physiopathology KW - Dopamine Antagonists -- pharmacology KW - Heroin Dependence -- prevention & control KW - Nucleus Accumbens -- metabolism KW - Behavior, Addictive -- physiopathology KW - Nucleus Accumbens -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68509434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Differential+effects+of+blockade+of+dopamine+D1-family+receptors+in+nucleus+accumbens+core+or+shell+on+reinstatement+of+heroin+seeking+induced+by+contextual+and+discrete+cues.&rft.au=Bossert%2C+Jennifer+M%3BPoles%2C+Gabriela+C%3BWihbey%2C+Kristina+A%3BKoya%2C+Eisuke%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12655&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Behav Neurosci. 1999 Apr;113(2):324-36 [10357457] Brain Res Rev. 2007 Nov;56(1):27-78 [17574681] Psychopharmacology (Berl). 2004 Nov;176(3-4):459-65 [15138757] J Neurosci. 2004 Nov 24;24(47):10726-30 [15564590] Neuropsychopharmacology. 2005 Feb;30(2):296-309 [15483559] Neuron. 2005 Mar 3;45(5):647-50 [15748840] J Neurosci. 2005 May 18;25(20):5061-5 [15901788] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Feb;31(2):363-74 [15957007] Neuroscience. 2006;139(3):877-87 [16516392] Psychopharmacology (Berl). 2006 Aug;187(2):143-53 [16724186] Neuropsychopharmacology. 2006 Oct;31(10):2197-209 [16341024] Psychopharmacology (Berl). 2006 Nov;189(1):1-16 [17019567] Neuroscience. 2006 Nov 17;143(1):25-38 [16949214] Neuropsychopharmacology. 2008 May;33(6):1402-12 [17653111] Neuropsychopharmacology. 2008 May;33(6):1413-25 [17712353] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4321-6 [10760299] Neuroscience. 2000;99(2):267-77 [10938432] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1976-81 [11172061] Psychopharmacology (Berl). 2001 Jun;156(1):98-107 [11465640] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuropsychopharmacology. 2001 Sep;25(3):361-72 [11522464] J Neurosci. 2001 Dec 1;21(23):9471-7 [11717381] Pharmacol Biochem Behav. 2002 Mar;71(3):517-29 [11830186] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Behav Neurosci. 2002 Feb;116(1):169-73 [11895178] Psychopharmacology (Berl). 2002 Apr;160(4):425-33 [11919670] J Neurosci. 2002 May 1;22(9):3312-20 [11978805] Neurosci Biobehav Rev. 2002 May;26(3):321-52 [12034134] Biol Psychiatry. 2002 Nov 15;52(10):976-86 [12437938] Neuropsychopharmacology. 2002 Dec;27(6):1006-15 [12464457] Neuropsychopharmacology. 2003 Feb;28(2):292-9 [12589382] Psychopharmacology (Berl). 2003 Jul;168(1-2):132-8 [12491029] J Neurosci. 2003 Jul 16;23(15):6295-303 [12867514] J Neurosci. 2003 Aug 13;23(19):7239-45 [12917356] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Neurosci Biobehav Rev. 2004 Jan;27(8):765-76 [15019426] Nat Neurosci. 2004 Apr;7(4):389-97 [15034590] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Trends Neurosci. 2004 Aug;27(8):468-74 [15271494] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Neuropharmacology. 2004;47 Suppl 1:227-41 [15464140] Arch Gen Psychiatry. 1973 May;28(5):611-6 [4700675] Brain Res. 1975 Mar 28;86(3):399-418 [234776] Pharmacol Rev. 1975 Sep;27(3):325-40 [817305] J Comp Neurol. 1978 Aug 1;180(3):545-80 [659674] Eur J Pharmacol. 1986 Oct 7;129(3):367-70 [3536532] Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):252-8 [2725702] J Comp Neurol. 1989 Nov 8;289(2):189-201 [2478598] Br J Pharmacol. 1991 Dec;104(4):1038-44 [1687364] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Neuroscience. 1992 Sep;50(1):149-62 [1383869] Neuroscience. 1992 Oct;50(4):751-67 [1448200] Brain Res. 1995 Sep 18;692(1-2):47-56 [8548319] J Neurosci. 1996 Mar 1;16(5):1957-63 [8774462] Eur J Neurosci. 1997 Dec;9(12):2541-8 [9517459] Neuroscience. 1999 Mar;89(2):473-89 [10077329] Psychopharmacology (Berl). 2007 Apr;191(3):689-703 [17072592] Neuroscience. 2007 May 11;146(2):525-36 [17360123] Ann N Y Acad Sci. 1999 Jun 29;877:140-56 [10415648] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Role of Cofilin-1 in Taurine Chloramine-Induced Premature Senescence of Human Lung Fibroblasts. T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40707161; 4755904 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Zdanov, Stephanie AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Lung KW - Senescence KW - Fibroblasts KW - Taurine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Role+of+Cofilin-1+in+Taurine+Chloramine-Induced+Premature+Senescence+of+Human+Lung+Fibroblasts.&rft.au=Zdanov%2C+Stephanie%3BShacter%2C+Emily&rft.aulast=Zdanov&rft.aufirst=Stephanie&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mitochondrially-Targeted Redox Agent Mitoquinone Enhances Doxorubicin-Induced Toxicity to Breast Cancer Cells While Protecting Cardiac Myocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705413; 4755903 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Rao, V Ashutosh AU - Klein, Sarah AU - Zielonka, Jacek AU - Kalyanaraman, B AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Toxicity KW - Breast cancer KW - Cardiomyocytes KW - Mitochondria KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=The+Mitochondrially-Targeted+Redox+Agent+Mitoquinone+Enhances+Doxorubicin-Induced+Toxicity+to+Breast+Cancer+Cells+While+Protecting+Cardiac+Myocytes&rft.au=Rao%2C+V+Ashutosh%3BKlein%2C+Sarah%3BZielonka%2C+Jacek%3BKalyanaraman%2C+B%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=V&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Phototoxicity, Crystalline Form and Light-Induced Free Radical Formation for Tattoo Inks Containing TiO2 T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704945; 4755817 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Wamer, Wayne AU - Yin, Jun Jie Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Tattoos KW - Phototoxicity KW - Free radicals KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Determination+of+Phototoxicity%2C+Crystalline+Form+and+Light-Induced+Free+Radical+Formation+for+Tattoo+Inks+Containing+TiO2&rft.au=Wamer%2C+Wayne%3BYin%2C+Jun+Jie&rft.aulast=Wamer&rft.aufirst=Wayne&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of In Vitro Assay for Rapid Evaluation of Activity and Safety of New Adjuvants. T2 - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AN - 40739101; 4770403 JF - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AU - Zaitseva, Marina AU - Romantseva, Tatiana AU - Golding, Hana Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 KW - Adjuvants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40739101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.atitle=Development+of+In+Vitro+Assay+for+Rapid+Evaluation+of+Activity+and+Safety+of+New+Adjuvants.&rft.au=Zaitseva%2C+Marina%3BRomantseva%2C+Tatiana%3BGolding%2C+Hana&rft.aulast=Zaitseva&rft.aufirst=Marina&rft.date=2007-11-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/mvaf_2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second Cancers Among 104760 Survivors of Cervical Cancer: Evaluation of Long-Term Risk AN - 20374165; 7743536 AB - BACKGROUND: Given the extended survival of patients diagnosed with cervical cancer, the large number of these women treated with radiotherapy, and the presence in this population of established cancer risk factors such as human papillomavirus (HPV) infection and cigarette smoking, it is important to clarify long-term trends in second cancer risk. METHODS: Using data from 104760 one-year survivors of cervical cancer reported to 13 population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States, we calculated standardized incidence ratios (SIRs) for second cancers overall and cancers at particular sites among women with cervical cancer, including cervical cancer patients who were treated or not treated with radiation, over more than 40 years of follow-up. Cox regression models were used to assess the time-varying association of radiotherapy with risk of second cancers and to assess the interaction of radiation treatment with age at diagnosis. All statistical tests were two-sided. RESULTS: Among 104760 one-year survivors of cervical cancer, the risk of all second cancers taken together was increased to a statistically significant extent (n = 12496; SIR = 1.30; 95% confidence interval [CI] = 1.28 to 1.33). Compared with the general population, in both radiotherapy (N = 52613) and no-radiotherapy groups (N = 27382), risks for HPV-related cancers (of the pharynx, genital sites, and rectum/anus) and smoking-related cancers (of the pharynx, trachea/bronchus/lung, pancreas, and urinary bladder) were elevated to a statistically significant extent. Cervical cancer patients treated with radiotherapy, but not those who did not receive radiotherapy, were at increased risk for all second cancers and cancers at heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites) beyond 40 years of follow-up compared with women in the general population. The association of radiotherapy with second cancer risk was modified by age at cervical cancer diagnosis for rectum/anus, genital sites, and urinary bladder, with higher hazard ratios for second cancer at younger ages of cervical cancer. After adjustment for competing mortality, the 40-year cumulative risk of any second cancer was higher among women diagnosed with cervical cancer before age 50 (22.2%; 95% CI = 21.5% to 22.8%) than among women diagnosed after age 50 (16.4%; 95% CI = 16.1% to 16.9%). CONCLUSION: Cervical cancer patients treated with radiotherapy are at increased risk of second cancers at sites in close proximity to the cervix beyond 40 years of follow-up. JF - Journal of the National Cancer Institute AU - Chaturvedi, Anil K AU - Engels, Eric A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Storm, Hans AU - Lynch, Charles F AU - Hall, Per AU - Langmark, Froydis AU - Pukkala, Eero AU - Kaijser, Magnus AU - Andersson, Michael AU - Fossaa, Sophie D AU - Joensuu, Heikki AU - Boice, John D AU - Kleinerman, Ruth A AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AKC, EAE, ESG, BEC, RAK, LBT) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1634 EP - 1643 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Age KW - Finland KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - radiotherapy KW - Cancer KW - urinary bladder KW - USA KW - Lung KW - Cigarette smoking KW - infection KW - Denmark KW - Norway KW - survival KW - Sweden KW - Human papillomavirus KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20374165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+Cancers+Among+104760+Survivors+of+Cervical+Cancer%3A+Evaluation+of+Long-Term+Risk&rft.au=Chaturvedi%2C+Anil+K%3BEngels%2C+Eric+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BStorm%2C+Hans%3BLynch%2C+Charles+F%3BHall%2C+Per%3BLangmark%2C+Froydis%3BPukkala%2C+Eero%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BFossaa%2C+Sophie+D%3BJoensuu%2C+Heikki%3BBoice%2C+John+D%3BKleinerman%2C+Ruth+A%3BTravis%2C+Lois+B&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1634&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; urinary bladder; Age; Lung; Cigarette smoking; infection; survival; radiotherapy; Cancer; Human papillomavirus; USA; Finland; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir; Denmark; Norway; Sweden ER - TY - JOUR T1 - Prospective Study of Serum Vitamin D and Cancer Mortality in the United States AN - 20373976; 7743532 AB - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P sub(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality. JF - Journal of the National Cancer Institute AU - Freedman, DMichal AU - Looker, Anne C AU - Chang, Shih-Chen AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1594 EP - 1602 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - risk reduction KW - USA KW - Age KW - vitamins KW - survival KW - Nutrition KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Prospective+Study+of+Serum+Vitamin+D+and+Cancer+Mortality+in+the+United+States&rft.au=Freedman%2C+DMichal%3BLooker%2C+Anne+C%3BChang%2C+Shih-Chen%3BGraubard%2C+Barry+I&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; vitamins; survival; Nutrition; Ethnic groups; Cancer; USA ER - TY - JOUR T1 - FDA's application of toxicological thresholds and structure activity analysis AN - 19466451; 8237703 JF - Toxicology AU - Cheeseman, MA AU - Dowla, N AU - McDougal, A J AU - Yang, C AD - HFS-200, 5100 Paint Branch Pkwy, College Park, MD 20740, USA, Mitchell.Cheeseman@fda.hhs.gov Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 130 EP - 131 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 240 IS - 3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=FDA%27s+application+of+toxicological+thresholds+and+structure+activity+analysis&rft.au=Cheeseman%2C+MA%3BDowla%2C+N%3BMcDougal%2C+A+J%3BYang%2C+C&rft.aulast=Cheeseman&rft.aufirst=MA&rft.date=2007-11-06&rft.volume=240&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Toxicology DO - http://dx.doi.org/10.1016/j.tox.2007.06.006 ER - TY - CPAPER T1 - Glycosylation of the Dengue 2 Virus E Protein at N67 is Critical for Virus Growth in Vitro but not for Growth in Intrathoracically-Inoculated Aedes aegypti Mosquitoes T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40747873; 4776812 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Roehrig, John T AU - Bryant, Juliet E AU - Calvert, Amanda E AU - Mesesan, Kyeen AU - Crabtree, Mary B AU - Volpe, Katharine E AU - Silengo, Shawn AU - Kinney, Richard M AU - Huang, Claire Y AU - Miller, Barry R Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Dengue KW - E protein KW - Glycosylation KW - Public health KW - Aquatic insects KW - Growth KW - Aedes aegypti KW - Dengue virus type 2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40747873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Glycosylation+of+the+Dengue+2+Virus+E+Protein+at+N67+is+Critical+for+Virus+Growth+in+Vitro+but+not+for+Growth+in+Intrathoracically-Inoculated+Aedes+aegypti+Mosquitoes&rft.au=Roehrig%2C+John+T%3BBryant%2C+Juliet+E%3BCalvert%2C+Amanda+E%3BMesesan%2C+Kyeen%3BCrabtree%2C+Mary+B%3BVolpe%2C+Katharine+E%3BSilengo%2C+Shawn%3BKinney%2C+Richard+M%3BHuang%2C+Claire+Y%3BMiller%2C+Barry+R&rft.aulast=Roehrig&rft.aufirst=John&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innovative Health Education: Using Media and Technology to Get Today's Youth to Eat Healthy and be Physically Active T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40782194; 4784015 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Dobday, Christine AU - Penn, Cecilia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Technology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Innovative+Health+Education%3A+Using+Media+and+Technology+to+Get+Today%27s+Youth+to+Eat+Healthy+and+be+Physically+Active&rft.au=Dobday%2C+Christine%3BPenn%2C+Cecilia&rft.aulast=Dobday&rft.aufirst=Christine&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the WOMAN Challenge: Women and Girls Out Moving Across the Nation T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40782175; 4784008 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hoersch, Michelle D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluating+the+WOMAN+Challenge%3A+Women+and+Girls+Out+Moving+Across+the+Nation&rft.au=Hoersch%2C+Michelle+D&rft.aulast=Hoersch&rft.aufirst=Michelle&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV/AIDS Protective Factors among Sexually Active African and Hispanic/Latino Adolescents T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40780440; 4784412 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bellamy, Nikki D AU - Wang, Min Qi Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Africa KW - Ethnic groups KW - Human immunodeficiency virus KW - Adolescents KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=HIV%2FAIDS+Protective+Factors+among+Sexually+Active+African+and+Hispanic%2FLatino+Adolescents&rft.au=Bellamy%2C+Nikki+D%3BWang%2C+Min+Qi&rft.aulast=Bellamy&rft.aufirst=Nikki&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges of Evaluating Health Marketing Campaigns: A Look at SPOT THE BLOCK T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777483; 4784115 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Davidson, Marjorie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Marketing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Challenges+of+Evaluating+Health+Marketing+Campaigns%3A+A+Look+at+SPOT+THE+BLOCK&rft.au=Davidson%2C+Marjorie&rft.aulast=Davidson&rft.aufirst=Marjorie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What's the Mix between Policy Decisions and Alcohol Damage: International, National, and State Perspectives T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777165; 4784410 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Mahony, Ann Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Alcohols KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=What%27s+the+Mix+between+Policy+Decisions+and+Alcohol+Damage%3A+International%2C+National%2C+and+State+Perspectives&rft.au=Mahony%2C+Ann&rft.aulast=Mahony&rft.aufirst=Ann&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strategies Use for Home Visitation for Adolescent Mothers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40776686; 4783820 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Adolescents KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Strategies+Use+for+Home+Visitation+for+Adolescent+Mothers&rft.au=Patterson%2C+Pam&rft.aulast=Patterson&rft.aufirst=Pam&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lead Exposure among Women of Child-Bearing Age United States, 2004. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40775801; 4782024 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Luckhaupt, Sara E AU - Calvert, Geoffrey M AU - Roscoe, Robert J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Lead KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Lead+Exposure+among+Women+of+Child-Bearing+Age+United+States%2C+2004.&rft.au=Luckhaupt%2C+Sara+E%3BCalvert%2C+Geoffrey+M%3BRoscoe%2C+Robert+J&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Garrett Lee Smith Memorial Campus Suicide Prevention Program: Lessons Learned and Unique Successes during the First Year T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40775427; 4784044 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Zeller, Eileen F AU - Davis, Nancy J AU - Hansen, Cynthia K AU - McKeon, Richard AU - Ritchie, Gail F AU - Mannix, Danyelle Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Suicide KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Garrett+Lee+Smith+Memorial+Campus+Suicide+Prevention+Program%3A+Lessons+Learned+and+Unique+Successes+during+the+First+Year&rft.au=Zeller%2C+Eileen+F%3BDavis%2C+Nancy+J%3BHansen%2C+Cynthia+K%3BMcKeon%2C+Richard%3BRitchie%2C+Gail+F%3BMannix%2C+Danyelle&rft.aulast=Zeller&rft.aufirst=Eileen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Update on the OWH Pregnancy Exposure Registry Listing T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40774847; 4784009 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Duvall-Miller, Elizabeth AU - O'Leary, Connie AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pregnancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40774847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=An+Update+on+the+OWH+Pregnancy+Exposure+Registry+Listing&rft.au=Sharma%2C+Pellavi%3BParekh%2C+Ameeta%3BDuvall-Miller%2C+Elizabeth%3BO%27Leary%2C+Connie%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Nurses: Back to the Community T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40774580; 4783948 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hickenbotham, Algia AU - Vassallo, Angela AU - Gamble, Rick AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Nursing KW - Public health KW - Medical personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40774580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Public+Health+Nurses%3A+Back+to+the+Community&rft.au=Hickenbotham%2C+Algia%3BVassallo%2C+Angela%3BGamble%2C+Rick%3BPatterson%2C+Pam&rft.aulast=Hickenbotham&rft.aufirst=Algia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicaid Asthma-Related Prescription Fills and the Associated Program Expenditures for Individuals Who had a Current Diagnosis of Asthma and an Ambulatory Service in CY 2002 Using the HHS/NIH/NHLBI NAEPP Guidelines: Age, Gender, and Race/Ethnicity Variations T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40773580; 4783834 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Benedict, M Beth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Respiratory diseases KW - Asthma KW - Ethnic groups KW - Guidelines KW - Age KW - Races KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40773580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Medicaid+Asthma-Related+Prescription+Fills+and+the+Associated+Program+Expenditures+for+Individuals+Who+had+a+Current+Diagnosis+of+Asthma+and+an+Ambulatory+Service+in+CY+2002+Using+the+HHS%2FNIH%2FNHLBI+NAEPP+Guidelines%3A+Age%2C+Gender%2C+and+Race%2FEthnicity+Variations&rft.au=Benedict%2C+M+Beth&rft.aulast=Benedict&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Supplements Labels Information for Consumers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771653; 4781380 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Goshorn, Jeanne C AU - Chang, H Florence AU - Moore, Dorothy R AU - Sun, Ying AU - Hudson, Vera H AU - Hazard, George F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dietary supplements KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Dietary+Supplements+Labels+Information+for+Consumers&rft.au=Goshorn%2C+Jeanne+C%3BChang%2C+H+Florence%3BMoore%2C+Dorothy+R%3BSun%2C+Ying%3BHudson%2C+Vera+H%3BHazard%2C+George+F&rft.aulast=Goshorn&rft.aufirst=Jeanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Do U.S. Consumers Handle Precut Bagged Lettuce? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771534; 4781450 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lin, Chung-Tung Jordan AU - Verrill, Linda A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=How+Do+U.S.+Consumers+Handle+Precut+Bagged+Lettuce%3F&rft.au=Lin%2C+Chung-Tung+Jordan%3BVerrill%2C+Linda+A&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Your Federal Government in Action: Active Policy Development to Protect you from Pandemic Influenza T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40770994; 4780505 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lamprecht, Lara AU - Raub, William F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Influenza KW - Pandemics KW - Policies KW - Governments KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Your+Federal+Government+in+Action%3A+Active+Policy+Development+to+Protect+you+from+Pandemic+Influenza&rft.au=Lamprecht%2C+Lara%3BRaub%2C+William+F&rft.aulast=Lamprecht&rft.aufirst=Lara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Electrical Breast Pumps Cleared by FDA in the Past Ten Years T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40770370; 4781434 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Byrne, Michelle L AU - Parekh, Ameeta AU - Pollard, Colin AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - FDA KW - Pumps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Comparison+of+Electrical+Breast+Pumps+Cleared+by+FDA+in+the+Past+Ten+Years&rft.au=Byrne%2C+Michelle+L%3BParekh%2C+Ameeta%3BPollard%2C+Colin%3BUhl%2C+Kathleen&rft.aulast=Byrne&rft.aufirst=Michelle&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing Local Solutions and Policies to Reduce Disparities in Health Care T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769828; 4782394 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Clancy, Carolyn M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Developing+Local+Solutions+and+Policies+to+Reduce+Disparities+in+Health+Care&rft.au=Clancy%2C+Carolyn+M&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asbestosis Mortality Surveillance in the United States, 1970-2004. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769570; 4782088 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bang, Ki Moon AU - Mazurek, Jacek AU - Syamlal, Girija AU - Wood, John M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Mortality KW - Asbestosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Asbestosis+Mortality+Surveillance+in+the+United+States%2C+1970-2004.&rft.au=Bang%2C+Ki+Moon%3BMazurek%2C+Jacek%3BSyamlal%2C+Girija%3BWood%2C+John+M&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Reporting of HCAHPS in Context. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769542; 4781994 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Miranda, David J AU - Carman, Kristin L AU - McGee, Jeanne Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Public+Reporting+of+HCAHPS+in+Context.&rft.au=Miranda%2C+David+J%3BCarman%2C+Kristin+L%3BMcGee%2C+Jeanne&rft.aulast=Miranda&rft.aufirst=David&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physical Workload and Low Back Disorders: Does Fairness Matter? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769400; 4782037 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fujishiro, Kaori AU - Heaney, Catherine A AU - Ferguson, Sue A AU - Allread, W Gary AU - Marras, William S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Working conditions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Physical+Workload+and+Low+Back+Disorders%3A+Does+Fairness+Matter%3F&rft.au=Fujishiro%2C+Kaori%3BHeaney%2C+Catherine+A%3BFerguson%2C+Sue+A%3BAllread%2C+W+Gary%3BMarras%2C+William+S&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Substance Abuse and Mental Health Issues: Policy, Prevention and Intervention T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769360; 4784332 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Clark, H Westley Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Intervention KW - Substance abuse KW - Mental disorders KW - Drug abuse KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Substance+Abuse+and+Mental+Health+Issues%3A+Policy%2C+Prevention+and+Intervention&rft.au=Clark%2C+H+Westley&rft.aulast=Clark&rft.aufirst=H&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Multilevel Analysis of Regional and State Disparities in Physical Inactivity and Activity Levels among US Children, 2003 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769271; 4782714 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Singh, Gopal K AU - Kogan, Michael D AU - Siahpush, Mohammad Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Physical activity KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Multilevel+Analysis+of+Regional+and+State+Disparities+in+Physical+Inactivity+and+Activity+Levels+among+US+Children%2C+2003&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3BSiahpush%2C+Mohammad&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conducting an Assessment and Intervention in Houston's Inner City T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769195; 4780427 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vassallo, Angela AU - Hickenbotham, Algia AU - Gamble, Rick AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Inner cities KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Conducting+an+Assessment+and+Intervention+in+Houston%27s+Inner+City&rft.au=Vassallo%2C+Angela%3BHickenbotham%2C+Algia%3BGamble%2C+Rick%3BPatterson%2C+Pam&rft.aulast=Vassallo&rft.aufirst=Angela&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Employee Assistance and Health/Wellness Programs T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769085; 4780144 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Galvin, Deborah Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Employee+Assistance+and+Health%2FWellness+Programs&rft.au=Galvin%2C+Deborah&rft.aulast=Galvin&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poor Health Status of Persons with Serious Mental Illness T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768843; 4783725 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Freeman, Elsie AU - Yoe, James Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Poor+Health+Status+of+Persons+with+Serious+Mental+Illness&rft.au=Freeman%2C+Elsie%3BYoe%2C+James&rft.aulast=Freeman&rft.aufirst=Elsie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quality of Inpatient Care Provided for Older Patients with Acute Myocardial Infarction (AMI): Findings from the National Healthcare Quality Report (NHQR). T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768627; 4781989 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gray, Darryl T AU - Brady, P Jeffrey Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Myocardial infarction KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Quality+of+Inpatient+Care+Provided+for+Older+Patients+with+Acute+Myocardial+Infarction+%28AMI%29%3A+Findings+from+the+National+Healthcare+Quality+Report+%28NHQR%29.&rft.au=Gray%2C+Darryl+T%3BBrady%2C+P+Jeffrey&rft.aulast=Gray&rft.aufirst=Darryl&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Missed Opportunities for Prevention: Overview of Findings from the 2006 National Healthcare Quality Report. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768591; 4781987 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Brady, P Jeffrey Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Health care KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Missed+Opportunities+for+Prevention%3A+Overview+of+Findings+from+the+2006+National+Healthcare+Quality+Report.&rft.au=Brady%2C+P+Jeffrey&rft.aulast=Brady&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Health Literacy Improvement: The Case for Coalition Building T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768450; 4782839 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Baur, Cynthia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Teeth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Oral+Health+Literacy+Improvement%3A+The+Case+for+Coalition+Building&rft.au=Baur%2C+Cynthia&rft.aulast=Baur&rft.aufirst=Cynthia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ventilator-Associated Pneumonia among Medicare Beneficiaries in Long-Term Care Hospitals. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768418; 4781975 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Buczko, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - Ventilator-associated pneumonia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Ventilator-Associated+Pneumonia+among+Medicare+Beneficiaries+in+Long-Term+Care+Hospitals.&rft.au=Buczko%2C+William&rft.aulast=Buczko&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation of the Supply and Cost of Treat-and-Release Visits to Hospital Emergency Departments T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768307; 4783721 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Friedman, Bernard AU - Owens, Pamela J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Variation+of+the+Supply+and+Cost+of+Treat-and-Release+Visits+to+Hospital+Emergency+Departments&rft.au=Friedman%2C+Bernard%3BOwens%2C+Pamela+J&rft.aulast=Friedman&rft.aufirst=Bernard&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flu Shots at Polling Sites: Partisan Politics or Public Health? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767986; 4783676 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Akyea, Oyeba Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Politics KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Flu+Shots+at+Polling+Sites%3A+Partisan+Politics+or+Public+Health%3F&rft.au=Akyea%2C+Oyeba&rft.aulast=Akyea&rft.aufirst=Oyeba&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the National Breastfeeding Awareness Campaign (Babies Were Born to be Breastfed): Is Risk Susceptibility Associated with Higher Breastfeeding Rates? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767876; 4781400 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Haynes, Suzanne G AU - Merewood, Anne AU - Chaudhuri, Jana AU - Fein, Sara B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Breast feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluation+of+the+National+Breastfeeding+Awareness+Campaign+%28Babies+Were+Born+to+be+Breastfed%29%3A+Is+Risk+Susceptibility+Associated+with+Higher+Breastfeeding+Rates%3F&rft.au=Haynes%2C+Suzanne+G%3BMerewood%2C+Anne%3BChaudhuri%2C+Jana%3BFein%2C+Sara+B&rft.aulast=Haynes&rft.aufirst=Suzanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Profile of HIV Antibody Testing among High Risk Adults T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767843; 4783600 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bellamy, Nikki D AU - Wang, Min Qi Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Human immunodeficiency virus KW - Antibodies KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+and+Profile+of+HIV+Antibody+Testing+among+High+Risk+Adults&rft.au=Bellamy%2C+Nikki+D%3BWang%2C+Min+Qi&rft.aulast=Bellamy&rft.aufirst=Nikki&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Developing National Objectives for the Next Decade T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767828; 4784291 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Royall, Penelope AU - Blakey, Carter AU - Paxman, Dalton G AU - Klein, Richard Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Healthy+People+2020%3A+Developing+National+Objectives+for+the+Next+Decade&rft.au=Royall%2C+Penelope%3BBlakey%2C+Carter%3BPaxman%2C+Dalton+G%3BKlein%2C+Richard&rft.aulast=Royall&rft.aufirst=Penelope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Formula use Education and Safety T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767744; 4781451 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Labiner-Wolfe, Judith AU - Fein, Sara B AU - Shealy, Katherine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Infant formulas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Formula+use+Education+and+Safety&rft.au=Labiner-Wolfe%2C+Judith%3BFein%2C+Sara+B%3BShealy%2C+Katherine&rft.aulast=Labiner-Wolfe&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Feeding Practices Study: Methods and Sample Characteristics T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767641; 4781395 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fein, Sara B AU - Labiner-Wolfe, Judith AU - Shealy, Katherine AU - Grummer-Strawn, Laurence AU - Li, Ruowei Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Infants KW - Feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Feeding+Practices+Study%3A+Methods+and+Sample+Characteristics&rft.au=Fein%2C+Sara+B%3BLabiner-Wolfe%2C+Judith%3BShealy%2C+Katherine%3BGrummer-Strawn%2C+Laurence%3BLi%2C+Ruowei&rft.aulast=Fein&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Infrastructure at Ports of Entry: Developing Effective Training Materials for U.S. Customs and Border Protection Officers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767446; 4780464 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hunter, David AU - Benenson, Gabrielle Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Customs KW - Public health KW - Training KW - Port installations KW - Infrastructure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Public+Health+Infrastructure+at+Ports+of+Entry%3A+Developing+Effective+Training+Materials+for+U.S.+Customs+and+Border+Protection+Officers&rft.au=Hunter%2C+David%3BBenenson%2C+Gabrielle&rft.aulast=Hunter&rft.aufirst=David&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview of the International Health Regulations (IHR): The U.S National Perspective T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767382; 4784308 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Jajosky, Ruth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=An+Overview+of+the+International+Health+Regulations+%28IHR%29%3A+The+U.S+National+Perspective&rft.au=Jajosky%2C+Ruth&rft.aulast=Jajosky&rft.aufirst=Ruth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2010: Oral Health and Looking Ahead T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767130; 4782841 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ochiai, Emmeline AU - Royall, Penelope Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Healthy+People+2010%3A+Oral+Health+and+Looking+Ahead&rft.au=Ochiai%2C+Emmeline%3BRoyall%2C+Penelope&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Criminalization Hypothesis: An Historical Policy Analysis T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766984; 4783731 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Morabito, Melissa Schaefer AU - Draine, Jeff Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Historical account KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Criminalization+Hypothesis%3A+An+Historical+Policy+Analysis&rft.au=Morabito%2C+Melissa+Schaefer%3BDraine%2C+Jeff&rft.aulast=Morabito&rft.aufirst=Melissa&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Community Immunization Program for Vulnerable Populations T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766772; 4781487 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bonilla, Doris W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Immunization KW - Vulnerability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Comprehensive+Community+Immunization+Program+for+Vulnerable+Populations&rft.au=Bonilla%2C+Doris+W&rft.aulast=Bonilla&rft.aufirst=Doris&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concordance of Household and Provider Reported Medical Conditions in the Medical Expenditure Panel Survey. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766587; 4782127 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Machlin, Steven AU - Beauregard, Karen M AU - Cohen, Joel Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Households KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Concordance+of+Household+and+Provider+Reported+Medical+Conditions+in+the+Medical+Expenditure+Panel+Survey.&rft.au=Machlin%2C+Steven%3BBeauregard%2C+Karen+M%3BCohen%2C+Joel&rft.aulast=Machlin&rft.aufirst=Steven&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Disparities in Cancer Screening among US Women Workers. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766524; 4782091 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fleming, Lora E AU - Lee, David AU - Christ, Sharon L AU - McCollister, Kathryn E AU - Arheart, Kristopher L AU - LeBlanc, William G AU - Caban-Martinez, Alberto J AU - Chung-Bridges, Katherine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Health+Disparities+in+Cancer+Screening+among+US+Women+Workers.&rft.au=Fleming%2C+Lora+E%3BLee%2C+David%3BChrist%2C+Sharon+L%3BMcCollister%2C+Kathryn+E%3BArheart%2C+Kristopher+L%3BLeBlanc%2C+William+G%3BCaban-Martinez%2C+Alberto+J%3BChung-Bridges%2C+Katherine&rft.aulast=Fleming&rft.aufirst=Lora&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spirituality and Cancer Care T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766409; 4783194 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Witte, Catherine AU - Baheshone, Harrison AU - Warne, Donald Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Spirituality+and+Cancer+Care&rft.au=Witte%2C+Catherine%3BBaheshone%2C+Harrison%3BWarne%2C+Donald&rft.aulast=Witte&rft.aufirst=Catherine&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Home Visitation in Vulnerable Populations T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766374; 4781482 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Patterson, Pam AU - Hickenbotham, Algia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Vulnerability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Home+Visitation+in+Vulnerable+Populations&rft.au=Patterson%2C+Pam%3BHickenbotham%2C+Algia&rft.aulast=Patterson&rft.aufirst=Pam&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrollment of Women and Racial Minorities in Clinical Trials for Diabetes Medications T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766358; 4783331 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pinnow, Ellen AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Thomas, Kimberly AU - Aljuburi, Lina AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Clinical trials KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Enrollment+of+Women+and+Racial+Minorities+in+Clinical+Trials+for+Diabetes+Medications&rft.au=Pinnow%2C+Ellen%3BSharma%2C+Pellavi%3BParekh%2C+Ameeta%3BThomas%2C+Kimberly%3BAljuburi%2C+Lina%3BUhl%2C+Kathleen&rft.aulast=Pinnow&rft.aufirst=Ellen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIOSH Brings Industry Sector Approach to Agriculture, Forestry and Fishing Safety and Health. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766348; 4782059 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Conway, George A AU - Husberg, Bradley J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Forestry KW - Fishing KW - Agriculture KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=NIOSH+Brings+Industry+Sector+Approach+to+Agriculture%2C+Forestry+and+Fishing+Safety+and+Health.&rft.au=Conway%2C+George+A%3BHusberg%2C+Bradley+J&rft.aulast=Conway&rft.aufirst=George&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oil and Gas Exploration and Extraction Injury Deaths: A Re-Emerging Hazard. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766289; 4782023 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Conway, George A AU - Mode, Nicolle A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Oil and gas exploration KW - Mortality KW - Injuries KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Oil+and+Gas+Exploration+and+Extraction+Injury+Deaths%3A+A+Re-Emerging+Hazard.&rft.au=Conway%2C+George+A%3BMode%2C+Nicolle+A&rft.aulast=Conway&rft.aufirst=George&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maternal and Child Health Initiatives in Sickle Cell Disease T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766209; 4780843 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lloyd-Puryear, Michele AU - Mann, Marie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Maternal+and+Child+Health+Initiatives+in+Sickle+Cell+Disease&rft.au=Lloyd-Puryear%2C+Michele%3BMann%2C+Marie&rft.aulast=Lloyd-Puryear&rft.aufirst=Michele&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tri Community a and I Project T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766004; 4782416 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gamble, Rick AU - Hickenbotham, Algia AU - Vassallo, Angela AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Tri+Community+a+and+I+Project&rft.au=Gamble%2C+Rick%3BHickenbotham%2C+Algia%3BVassallo%2C+Angela%3BPatterson%2C+Pam&rft.aulast=Gamble&rft.aufirst=Rick&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trajectories of Criminal Justice Involvement among a State Mental Health Agency's Clientele: Findings from a 10-Year Cohort Study T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765905; 4783729 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fisher, William H AU - Banks, Steven M AU - Roy-Bujnowski, Kristen AU - Clayfield, Jonathan AU - Grudzinskas, Albert J AU - Wolff, Nancy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Trajectories+of+Criminal+Justice+Involvement+among+a+State+Mental+Health+Agency%27s+Clientele%3A+Findings+from+a+10-Year+Cohort+Study&rft.au=Fisher%2C+William+H%3BBanks%2C+Steven+M%3BRoy-Bujnowski%2C+Kristen%3BClayfield%2C+Jonathan%3BGrudzinskas%2C+Albert+J%3BWolff%2C+Nancy&rft.aulast=Fisher&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Screening and Brief Intervention Program with Alaskan Natives: The Connections SBIRT Experience T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765770; 4780107 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Stegbauer, Thomas AU - Kleinschmidt, Erich AU - Sommer, Shannon AU - Naquin, Valerie AU - Trojan, Jodi AU - Cage, Brandi AU - Nelson, Travette AU - Brady, Thomas M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Intervention KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Screening+and+Brief+Intervention+Program+with+Alaskan+Natives%3A+The+Connections+SBIRT+Experience&rft.au=Stegbauer%2C+Thomas%3BKleinschmidt%2C+Erich%3BSommer%2C+Shannon%3BNaquin%2C+Valerie%3BTrojan%2C+Jodi%3BCage%2C+Brandi%3BNelson%2C+Travette%3BBrady%2C+Thomas+M&rft.aulast=Stegbauer&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Community Based Participatory Approaches to Provide Genetics Education T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765684; 4782532 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Kyler, Panelpha AU - Puryear, Michele Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Genetics KW - Education KW - Community involvement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+Community+Based+Participatory+Approaches+to+Provide+Genetics+Education&rft.au=Kyler%2C+Panelpha%3BPuryear%2C+Michele&rft.aulast=Kyler&rft.aufirst=Panelpha&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Can the Vitamin D Needs of the North American Public be Met by Current Supplementation and Fortification Practices in the Absence of Sun Exposure? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765544; 4780258 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Calvo, Mona S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - North America KW - Vitamin D KW - Sun KW - Supplementation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Can+the+Vitamin+D+Needs+of+the+North+American+Public+be+Met+by+Current+Supplementation+and+Fortification+Practices+in+the+Absence+of+Sun+Exposure%3F&rft.au=Calvo%2C+Mona+S&rft.aulast=Calvo&rft.aufirst=Mona&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health Issues and SAMHSA Resources T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765255; 4782476 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Power, A.Kathryn Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Mental+Health+Issues+and+SAMHSA+Resources&rft.au=Power%2C+A.Kathryn&rft.aulast=Power&rft.aufirst=A.Kathryn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the IHI-Model for Improvement and a Brief Encounter Education Format to Implement Best Practices in Long Term Care Settings T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764793; 4782644 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bigley, Mary Beth AU - Simon, Lin Noyes AU - Lunsford, Beverly Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Best practices KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+the+IHI-Model+for+Improvement+and+a+Brief+Encounter+Education+Format+to+Implement+Best+Practices+in+Long+Term+Care+Settings&rft.au=Bigley%2C+Mary+Beth%3BSimon%2C+Lin+Noyes%3BLunsford%2C+Beverly&rft.aulast=Bigley&rft.aufirst=Mary&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fall-Related Hospitalizations among Elderly Medicare Beneficiaries T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764713; 4782795 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Buczko, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Elderly KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Fall-Related+Hospitalizations+among+Elderly+Medicare+Beneficiaries&rft.au=Buczko%2C+William&rft.aulast=Buczko&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent Developments in the National, Standardized, Publicly Reported Survey of Patients' Perspectives of Hospital Care (HCAHPS). T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764677; 4781990 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lehrman, William G AU - Goldstein, Elizabeth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Recent+Developments+in+the+National%2C+Standardized%2C+Publicly+Reported+Survey+of+Patients%27+Perspectives+of+Hospital+Care+%28HCAHPS%29.&rft.au=Lehrman%2C+William+G%3BGoldstein%2C+Elizabeth&rft.aulast=Lehrman&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bringing Science to Consumers: Designing Appropriate Health Education Materials T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764612; 4784147 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lemon, Alison Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Bringing+Science+to+Consumers%3A+Designing+Appropriate+Health+Education+Materials&rft.au=Lemon%2C+Alison&rft.aulast=Lemon&rft.aufirst=Alison&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differential in National Estimates for Medical Device-Associated Adverse Events from Emergency Departments T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764266; 4783206 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Wang, Cunlin AU - Hefflin, Brockton AU - Marinica-Dabic, Danic AU - Loyo-Berrios, Nilsa AU - Zhou, Jie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Gender+Differential+in+National+Estimates+for+Medical+Device-Associated+Adverse+Events+from+Emergency+Departments&rft.au=Wang%2C+Cunlin%3BHefflin%2C+Brockton%3BMarinica-Dabic%2C+Danic%3BLoyo-Berrios%2C+Nilsa%3BZhou%2C+Jie&rft.aulast=Wang&rft.aufirst=Cunlin&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using National Outcomes Data to Improve the Health of Seniors T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763947; 4782773 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bowen, Sonya E AU - Haffer, Samuel C AU - Long, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Aging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+National+Outcomes+Data+to+Improve+the+Health+of+Seniors&rft.au=Bowen%2C+Sonya+E%3BHaffer%2C+Samuel+C%3BLong%2C+William&rft.aulast=Bowen&rft.aufirst=Sonya&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health and Safety for Home Healthcare Workers: Politics, Policy and Public Health for a Unique Worker Population T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763905; 4782766 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gong, Fang AU - Baron, Sherry L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Politics KW - Public health KW - Medical personnel KW - Policies KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Health+and+Safety+for+Home+Healthcare+Workers%3A+Politics%2C+Policy+and+Public+Health+for+a+Unique+Worker+Population&rft.au=Gong%2C+Fang%3BBaron%2C+Sherry+L&rft.aulast=Gong&rft.aufirst=Fang&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HRSA Funded Grantees Convened in a Strategic Process Intended to Enhance Funding Impact through Collaboration T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763886; 4783618 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Alos, Victor AU - Alston, Kenneth AU - Roberts, Alma AU - Williams, Jackie AU - Reed-Vance, Maxine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=HRSA+Funded+Grantees+Convened+in+a+Strategic+Process+Intended+to+Enhance+Funding+Impact+through+Collaboration&rft.au=Alos%2C+Victor%3BAlston%2C+Kenneth%3BRoberts%2C+Alma%3BWilliams%2C+Jackie%3BReed-Vance%2C+Maxine&rft.aulast=Alos&rft.aufirst=Victor&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Hurricanes Katrina and Rita and their Aftermath on Substance use and Mental Illness T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763649; 4779944 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colpe, Lisa J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - Substance use KW - Hurricanes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Impact+of+Hurricanes+Katrina+and+Rita+and+their+Aftermath+on+Substance+use+and+Mental+Illness&rft.au=Colpe%2C+Lisa+J&rft.aulast=Colpe&rft.aufirst=Lisa&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Feeding Practices Study II: Methods and Sample Characteristics T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763471; 4783661 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fein, Sara B AU - Labiner-Wolfe, Judith AU - Shealy, Katherine AU - Grummer-Strawn, Laurence AU - Li, Ruowei Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Infants KW - Feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Feeding+Practices+Study+II%3A+Methods+and+Sample+Characteristics&rft.au=Fein%2C+Sara+B%3BLabiner-Wolfe%2C+Judith%3BShealy%2C+Katherine%3BGrummer-Strawn%2C+Laurence%3BLi%2C+Ruowei&rft.aulast=Fein&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Childrens' Pathways to Care T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763270; 4783228 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pfefferle, Susan G AU - Spitznagel, Edward L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Childrens%27+Pathways+to+Care&rft.au=Pfefferle%2C+Susan+G%3BSpitznagel%2C+Edward+L&rft.aulast=Pfefferle&rft.aufirst=Susan&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - U.S./Vietnam Scientific Cooperation: Building Capacity to Evaluate Agent Orange/Dioxin Soil Contamination T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762816; 4783522 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sweeney, Marie Haring AU - Farland, William H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Vietnam KW - 2,4,5-T KW - Soil pollution KW - Dioxin KW - Contamination KW - Agent Orange KW - Cooperation KW - Chlorinated hydrocarbons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=U.S.%2FVietnam+Scientific+Cooperation%3A+Building+Capacity+to+Evaluate+Agent+Orange%2FDioxin+Soil+Contamination&rft.au=Sweeney%2C+Marie+Haring%3BFarland%2C+William+H&rft.aulast=Sweeney&rft.aufirst=Marie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lack of Planned Subgroup Analysis: Review of Drug Protocols Submitted to the Food and Drug Administration T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762701; 4783596 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sharma, Pellavi AU - Pinnow, Ellen AU - Scott, Pamela AU - Derbis, Janelle AU - Toigo, Theresa AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Drugs KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Lack+of+Planned+Subgroup+Analysis%3A+Review+of+Drug+Protocols+Submitted+to+the+Food+and+Drug+Administration&rft.au=Sharma%2C+Pellavi%3BPinnow%2C+Ellen%3BScott%2C+Pamela%3BDerbis%2C+Janelle%3BToigo%2C+Theresa%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pain Management for Nursing Home Residents: Results from the 2004 National Nursing Home Survey T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762399; 4781253 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sangl, Judith AU - Remsburg, Robin E AU - Valverde, Roberto Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pain KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Pain+Management+for+Nursing+Home+Residents%3A+Results+from+the+2004+National+Nursing+Home+Survey&rft.au=Sangl%2C+Judith%3BRemsburg%2C+Robin+E%3BValverde%2C+Roberto&rft.aulast=Sangl&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morbidity and Mortality Associated with the Nonmedical use of Dextromethorphan T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762345; 4779946 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Crane, Elizabeth H AU - Poneleit, Kathy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mortality KW - Morbidity KW - Dextromethorphan KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Morbidity+and+Mortality+Associated+with+the+Nonmedical+use+of+Dextromethorphan&rft.au=Crane%2C+Elizabeth+H%3BPoneleit%2C+Kathy&rft.aulast=Crane&rft.aufirst=Elizabeth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Misuse of OTC Cold and Cough Medications: New Data from NSDUH T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762055; 4779945 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colliver, James D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cough KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Misuse+of+OTC+Cold+and+Cough+Medications%3A+New+Data+from+NSDUH&rft.au=Colliver%2C+James+D&rft.aulast=Colliver&rft.aufirst=James&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiology of Invasive Pneumococcal Disease in the Era of Childhood Vaccination: Newark, New Jersey T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761986; 4781047 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sison, Erica J AU - Sinha, Anushua AU - Tasslimi, Azadeh AU - Leszczyniecka, Zofia AU - McGowan, Marsha AU - McHugh, Lisa A AU - Thomas, Polly AU - Wenger, Peter Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, New Jersey KW - Children KW - Vaccination KW - Epidemiology KW - Streptococcus pneumoniae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Epidemiology+of+Invasive+Pneumococcal+Disease+in+the+Era+of+Childhood+Vaccination%3A+Newark%2C+New+Jersey&rft.au=Sison%2C+Erica+J%3BSinha%2C+Anushua%3BTasslimi%2C+Azadeh%3BLeszczyniecka%2C+Zofia%3BMcGowan%2C+Marsha%3BMcHugh%2C+Lisa+A%3BThomas%2C+Polly%3BWenger%2C+Peter&rft.aulast=Sison&rft.aufirst=Erica&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Website Promoting Early Detection and Screening Practice: Http://sbirt.samhsa.gov T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761077; 4779786 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Stegbauer, Thomas AU - Brubach, April L AU - O'Brien, Lisa AU - Fuller, Eric AU - Hoglund, Julia AU - Nelson, Travette AU - Brady, Thomas M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Website+Promoting+Early+Detection+and+Screening+Practice%3A+Http%3A%2F%2Fsbirt.samhsa.gov&rft.au=Stegbauer%2C+Thomas%3BBrubach%2C+April+L%3BO%27Brien%2C+Lisa%3BFuller%2C+Eric%3BHoglund%2C+Julia%3BNelson%2C+Travette%3BBrady%2C+Thomas+M&rft.aulast=Stegbauer&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Potentail Disability Measures for the National Healthcare Quality and Disparities Reports T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761059; 4780867 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Chevarley, Frances M AU - Altman, Barbara M AU - Moy, Ernest Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Disabilities KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Identification+of+Potentail+Disability+Measures+for+the+National+Healthcare+Quality+and+Disparities+Reports&rft.au=Chevarley%2C+Frances+M%3BAltman%2C+Barbara+M%3BMoy%2C+Ernest&rft.aulast=Chevarley&rft.aufirst=Frances&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Planning for an Urban Community Health Survey - Insights from Focus Groups in Newark, NJ T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761030; 4781114 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Springer, M AU - Thomas, P A AU - Edwards, D AU - McGowan, M AU - Passannante, M AU - Rosenblum, D M AU - Holland, B K AU - Houston, S AU - Brown, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Urban areas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Planning+for+an+Urban+Community+Health+Survey+-+Insights+from+Focus+Groups+in+Newark%2C+NJ&rft.au=Springer%2C+M%3BThomas%2C+P+A%3BEdwards%2C+D%3BMcGowan%2C+M%3BPassannante%2C+M%3BRosenblum%2C+D+M%3BHolland%2C+B+K%3BHouston%2C+S%3BBrown%2C+D+R&rft.aulast=Springer&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - They're Either Prepared or They're Not! Prevalence and Risk Factors for the Presence of Carbon Monoxide Alarms in Maine Households T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760913; 4781062 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Graber, Judith M AU - Mittal, Prashant AU - Smith, Andrew E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Maine KW - Carbon monoxide KW - Households KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=They%27re+Either+Prepared+or+They%27re+Not%21+Prevalence+and+Risk+Factors+for+the+Presence+of+Carbon+Monoxide+Alarms+in+Maine+Households&rft.au=Graber%2C+Judith+M%3BMittal%2C+Prashant%3BSmith%2C+Andrew+E&rft.aulast=Graber&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current and Future Workforce Issues in Substance Abuse Prevention and Early Intervention in the Workplace T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760716; 4779912 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Galvin, Deborah AU - Schlenger, William AU - Karuntzos, Georgia AU - Bray, Jeremy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Intervention KW - Substance abuse KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Current+and+Future+Workforce+Issues+in+Substance+Abuse+Prevention+and+Early+Intervention+in+the+Workplace&rft.au=Galvin%2C+Deborah%3BSchlenger%2C+William%3BKaruntzos%2C+Georgia%3BBray%2C+Jeremy&rft.aulast=Galvin&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Burn Casualty Preparedness: A Program Evaluation of the Burn Asset Resource Tracking System. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760258; 4781642 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hsu, Sophia AU - Lavin, Roberta AU - Borden, Cheryl Ann AU - Bardack, Stephanie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Burns KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Burn+Casualty+Preparedness%3A+A+Program+Evaluation+of+the+Burn+Asset+Resource+Tracking+System.&rft.au=Hsu%2C+Sophia%3BLavin%2C+Roberta%3BBorden%2C+Cheryl+Ann%3BBardack%2C+Stephanie&rft.aulast=Hsu&rft.aufirst=Sophia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Health Takes Priority with Head Start T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759992; 4782856 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Rossetti, John AU - Goodman, Harry AU - Jackson, Beverly Roberson AU - Holt, Katrina A AU - Geurink, Kathy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Head KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Oral+Health+Takes+Priority+with+Head+Start&rft.au=Rossetti%2C+John%3BGoodman%2C+Harry%3BJackson%2C+Beverly+Roberson%3BHolt%2C+Katrina+A%3BGeurink%2C+Kathy&rft.aulast=Rossetti&rft.aufirst=John&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Premigration Factors and Mental Health among Asian Immigrants T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759476; 4782996 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gong, Fang Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Immigrants KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Premigration+Factors+and+Mental+Health+among+Asian+Immigrants&rft.au=Gong%2C+Fang&rft.aulast=Gong&rft.aufirst=Fang&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Obesity in Newark Adults 18 Years and Older: Using State and National Data T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759444; 4780948 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Springer, M AU - Thomas, P A AU - O'Dowd, K J AU - McGowan, M AU - Halperin, W E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Obesity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+of+Obesity+in+Newark+Adults+18+Years+and+Older%3A+Using+State+and+National+Data&rft.au=Springer%2C+M%3BThomas%2C+P+A%3BO%27Dowd%2C+K+J%3BMcGowan%2C+M%3BHalperin%2C+W+E&rft.aulast=Springer&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Occupation and Industry Data Collection in the NH State Cancer Registry (NHSCR) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757753; 4781327 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Armenti, Karla R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Data collection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluation+of+Occupation+and+Industry+Data+Collection+in+the+NH+State+Cancer+Registry+%28NHSCR%29&rft.au=Armenti%2C+Karla+R&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Re-Injury on Military Discharge from the US Army. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757745; 4781770 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Tiesman, Hope AU - Peek-Asa, Corinne AU - Zwerling, Craig AU - Whitten, Paul AU - Amoroso, Paul J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Military KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Effects+of+Re-Injury+on+Military+Discharge+from+the+US+Army.&rft.au=Tiesman%2C+Hope%3BPeek-Asa%2C+Corinne%3BZwerling%2C+Craig%3BWhitten%2C+Paul%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Occupational and Non-Occupational Injuries in the U.S. Army. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757089; 4781769 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Tiesman, Hope AU - Peek-Asa, Corinne AU - Zwerling, Craig AU - Yang, Jingzhen AU - Amoroso, Paul J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Sex KW - Injuries KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Gender+Differences+in+Occupational+and+Non-Occupational+Injuries+in+the+U.S.+Army.&rft.au=Tiesman%2C+Hope%3BPeek-Asa%2C+Corinne%3BZwerling%2C+Craig%3BYang%2C+Jingzhen%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Illicit Drug use and Health Conditions: Results from the 2005 and 2006 National Survey on Drug use and Health T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757059; 4779911 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Han, Beth AU - Colliver, James AU - Gfroerer, Joe Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Relationship+between+Illicit+Drug+use+and+Health+Conditions%3A+Results+from+the+2005+and+2006+National+Survey+on+Drug+use+and+Health&rft.au=Han%2C+Beth%3BColliver%2C+James%3BGfroerer%2C+Joe&rft.aulast=Han&rft.aufirst=Beth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interdependence of Mental Health, Physical Health and Health Risk from the Maine BRFSS T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40756629; 4781188 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Freeman, Elsie AU - Neale, Kip AU - Yoe, James Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Maine KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Interdependence+of+Mental+Health%2C+Physical+Health+and+Health+Risk+from+the+Maine+BRFSS&rft.au=Freeman%2C+Elsie%3BNeale%2C+Kip%3BYoe%2C+James&rft.aulast=Freeman&rft.aufirst=Elsie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community-Based Survey Methods and Knowledge T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40755602; 4780719 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Manning, Thomas L AU - Seschillie, Bess K AU - Elwood, Jerry AU - Norton, Bernice Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Community involvement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40755602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Community-Based+Survey+Methods+and+Knowledge&rft.au=Manning%2C+Thomas+L%3BSeschillie%2C+Bess+K%3BElwood%2C+Jerry%3BNorton%2C+Bernice&rft.aulast=Manning&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Autism Spectrum Disorders in Medicaid and Associated Health Care Utilization T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40754738; 4781301 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Anderson, Karyn Kai AU - Mandell, David S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Health care KW - Autism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+of+Autism+Spectrum+Disorders+in+Medicaid+and+Associated+Health+Care+Utilization&rft.au=Anderson%2C+Karyn+Kai%3BMandell%2C+David+S&rft.aulast=Anderson&rft.aufirst=Karyn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial and Ethnic Minority Primary Care Providers: Improving Access and Patient-Provider Communication T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40754411; 4781322 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Moy, Ernest AU - Hogan, Sara Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Racial+and+Ethnic+Minority+Primary+Care+Providers%3A+Improving+Access+and+Patient-Provider+Communication&rft.au=Moy%2C+Ernest%3BHogan%2C+Sara&rft.aulast=Moy&rft.aufirst=Ernest&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morris Water Maze Performance of Adult Rats Appears Insensitive to Lifetime Acrylamide Treatment T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39622795; 4711321 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Smith, M E AU - Paule, M G AU - Garey, J D AU - Ferguson, S A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Acrylamide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Morris+Water+Maze+Performance+of+Adult+Rats+Appears+Insensitive+to+Lifetime+Acrylamide+Treatment&rft.au=Smith%2C+M+E%3BPaule%2C+M+G%3BGarey%2C+J+D%3BFerguson%2C+S+A&rft.aulast=Smith&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Chronic Stress Regimen with Unpredictable Stressor Presentation Decreases the Density of Spines on the CA3 Pyramidal Neurons of the Hippocampus in the Adult C57BL/6J Male Mouse T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39619968; 4718872 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Miller, D B AU - Bachstetter, A D AU - Mervis, R J AU - Benkovic, S A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Stress KW - Spine KW - Pyramidal cells KW - Hippocampus KW - Spines KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Chronic+Stress+Regimen+with+Unpredictable+Stressor+Presentation+Decreases+the+Density+of+Spines+on+the+CA3+Pyramidal+Neurons+of+the+Hippocampus+in+the+Adult+C57BL%2F6J+Male+Mouse&rft.au=Miller%2C+D+B%3BBachstetter%2C+A+D%3BMervis%2C+R+J%3BBenkovic%2C+S+A&rft.aulast=Miller&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Phencyclidine or Ketamine Treatment Significantly Slows Body Weight Gain and Alters Early Preweaning Behaviors in Sprague-Dawley Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39598072; 4717302 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Boctor, S Y AU - Sadovova, N AU - Zou, X AU - Wang, C AU - Ferguson, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Body weight KW - Rats KW - Body weight gain KW - Phencyclidine KW - Ketamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Phencyclidine+or+Ketamine+Treatment+Significantly+Slows+Body+Weight+Gain+and+Alters+Early+Preweaning+Behaviors+in+Sprague-Dawley+Rats&rft.au=Boctor%2C+S+Y%3BSadovova%2C+N%3BZou%2C+X%3BWang%2C+C%3BFerguson%2C+S&rft.aulast=Boctor&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Exogenous Activation of Proteinase-activated Receptors in the Capsaicin Induced Central Sensitization of Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39572016; 4706563 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zhang, X AU - Lei, Y AU - Fang, L AU - Willis, W D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Capsaicin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39572016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Exogenous+Activation+of+Proteinase-activated+Receptors+in+the+Capsaicin+Induced+Central+Sensitization+of+Rats&rft.au=Zhang%2C+X%3BLei%2C+Y%3BFang%2C+L%3BWillis%2C+W+D&rft.aulast=Zhang&rft.aufirst=X&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sodium Titanate Nanowires: Fabrication and Interaction with PC-12 Cells T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39567421; 4711953 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ali, H K AU - Padilla, C S AU - Tian, R AU - Duhart, H L AU - Ali, S F AU - Patterson, T A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39567421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sodium+Titanate+Nanowires%3A+Fabrication+and+Interaction+with+PC-12+Cells&rft.au=Ali%2C+H+K%3BPadilla%2C+C+S%3BTian%2C+R%3BDuhart%2C+H+L%3BAli%2C+S+F%3BPatterson%2C+T+A&rft.aulast=Ali&rft.aufirst=H&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Acrylamide and Acetyl-L-carnitine on Motor Nerve Conduction Velocity and Grip Strength in Adult Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39563333; 4710011 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Garey, J D AU - Beaudoin, M A AU - Paule, M G AU - Skinner, R D AU - Binienda, Z K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Velocity KW - Rats KW - Acrylamide KW - Acetyl-L-carnitine KW - Nerve conduction KW - Nerves KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39563333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Acrylamide+and+Acetyl-L-carnitine+on+Motor+Nerve+Conduction+Velocity+and+Grip+Strength+in+Adult+Rats&rft.au=Garey%2C+J+D%3BBeaudoin%2C+M+A%3BPaule%2C+M+G%3BSkinner%2C+R+D%3BBinienda%2C+Z+K&rft.aulast=Garey&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Supraphysiological Levels of Corticosterone Attenuate Glial Activation and Provide Protection Against Excitotoxicity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39560358; 4706160 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Benkovic, S A AU - O'callaghan, J P AU - Miller, D B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Excitotoxicity KW - Corticosterone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39560358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Supraphysiological+Levels+of+Corticosterone+Attenuate+Glial+Activation+and+Provide+Protection+Against+Excitotoxicity&rft.au=Benkovic%2C+S+A%3BO%27callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methamphetamine Dysregulates Astrocytes Functions, Increasing Oxidative Stress T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39536584; 4716810 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ali, S F AU - Jiang, H AU - Rongzhu, L AU - Milatovic, D AU - Aschner, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Oxidative stress KW - Methamphetamine KW - Astrocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39536584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Methamphetamine+Dysregulates+Astrocytes+Functions%2C+Increasing+Oxidative+Stress&rft.au=Ali%2C+S+F%3BJiang%2C+H%3BRongzhu%2C+L%3BMilatovic%2C+D%3BAschner%2C+M&rft.aulast=Ali&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Time Course of the Scavenging of Axons in Caudate/Putamen after a Neurotoxic Amphetamine Exposure Indicates Many are of Thalamic Origin T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39530415; 4711920 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bowyer, J F AU - Schmued, L C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurotoxicity KW - Putamen KW - Amphetamine KW - Thalamus KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Time+Course+of+the+Scavenging+of+Axons+in+Caudate%2FPutamen+after+a+Neurotoxic+Amphetamine+Exposure+Indicates+Many+are+of+Thalamic+Origin&rft.au=Bowyer%2C+J+F%3BSchmued%2C+L+C&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of the JAK-STAT3 Pathway is Associated with the Induction of Astrogliosis in Multiple Models of Neurotoxicity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39515255; 4713320 JF - 2007 Annual Meeting of the Society for Neuroscience AU - O'callaghan, J P AU - Sriram, K AU - Benkovic, S A AU - Miller, D B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurotoxicity KW - Gliosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39515255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+of+the+JAK-STAT3+Pathway+is+Associated+with+the+Induction+of+Astrogliosis+in+Multiple+Models+of+Neurotoxicity&rft.au=O%27callaghan%2C+J+P%3BSriram%2C+K%3BBenkovic%2C+S+A%3BMiller%2C+D+B&rft.aulast=O%27callaghan&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evaluation of Bone and Mineral Metabolism in Patients Recently Diagnosed With Leprosy AN - 746010624; 13136920 AB - This study was conducted to evaluate patients recently diagnosed with the tuberculoid and lepromatous forms of leprosy for bone mass, bone remodeling, and hormones related to mineral control. Eleven normal control individuals (CG) and 12 patients with leprosy (LG) matched for physical characteristics were submitted to evaluation of bone mass density (BMD) and to the determination of serum levels of PTH, 25-hydroxyvitamin D [25(OH)D], testosterone, LH, FSH, osteocalcin (OC), and urinary levels of deoxypyridinoline (DPD). The T score of lumbar spine and total radius (mean c SD) were significantly lower in leprosy patients (L1-L4: CG = -0.7 c 1.5 vs LG = -1.8 c 1.0 SD, P < 0.04, and total radius: CG = -1.43 c 0.6 vs LG = -2.1 c 0.8 SD, P < 0.02), whereas no significant differences were observed in total hip or femoral neck T score. However, at all sites, the rate of low bone mass (T score < -1.0) was higher in LG (femoral neck: CG = 18% vs LG = 50%, total hip: CG = 27% vs LG = 42%). There was a significant difference in albumin and PTH levels between groups but not in serum 25(OH)D and OC levels or urinary DPD levels. The present results indicate that bone mass loss is an early event in leprosy patients and frequently is already present at diagnosis. Its etiopathogenesis is multifactorial, and further studies are needed to determine the most efficient way to prevent fractures in this condition. The data obtained in the present study need confirmation by the evaluation of a larger sample. JF - American Journal of the Medical Sciences AU - Ribeiro, F B AU - Pereira, FDA AU - Muller, E AU - Foss, N T AU - de Paula, FJA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 322 EP - 326 VL - 334 IS - 5 SN - 0002-9629, 0002-9629 KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Physical characteristics KW - Data processing KW - Follicle-stimulating hormone KW - Osteocalcin KW - Fractures KW - 25-Hydroxyvitamin D KW - Hormones KW - Femur KW - Leprosy KW - Serum levels KW - Spine (lumbar) KW - Testosterone KW - Bone mineral density KW - Radius KW - Luteinizing hormone KW - Albumin KW - Parathyroid hormone KW - Bone mass KW - Bone remodelling KW - deoxypyridinoline KW - Metabolism KW - Hip KW - J 02400:Human Diseases KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746010624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+the+Medical+Sciences&rft.atitle=Evaluation+of+Bone+and+Mineral+Metabolism+in+Patients+Recently+Diagnosed+With+Leprosy&rft.au=Ribeiro%2C+F+B%3BPereira%2C+FDA%3BMuller%2C+E%3BFoss%2C+N+T%3Bde+Paula%2C+FJA&rft.aulast=Ribeiro&rft.aufirst=F&rft.date=2007-11-01&rft.volume=334&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+the+Medical+Sciences&rft.issn=00029629&rft_id=info:doi/10.1097%2FMAJ.0b013e318142bafb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Physical characteristics; Follicle-stimulating hormone; Data processing; Osteocalcin; 25-Hydroxyvitamin D; Fractures; Femur; Hormones; Leprosy; Serum levels; Spine (lumbar); Testosterone; Bone mineral density; Radius; Luteinizing hormone; Albumin; Parathyroid hormone; Bone mass; Bone remodelling; deoxypyridinoline; Metabolism; Hip DO - http://dx.doi.org/10.1097/MAJ.0b013e318142bafb ER - TY - JOUR T1 - Gaussian representation of high-intensity focused ultrasound beams. AN - 742780707; pmid-18189543 AB - A method for fast numerical simulation of high-intensity focused ultrasound beams is derived. The method is based on the frequency-domain representation of the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation, and assumes for each harmonic a Gaussian transverse pressure distribution at all distances from the transducer face. The beamwidths of the harmonics are constrained to vary inversely with the square root of the harmonic number, and as such this method may be viewed as an extension of a quasilinear approximation. The technique is capable of determining pressure or intensity fields of moderately nonlinear high-intensity focused ultrasound beams in water or biological tissue, usually requiring less than a minute of computer time on a modern workstation. Moreover, this method is particularly well suited to high-gain simulations since, unlike traditional finite-difference methods, it is not subject to resolution limitations in the transverse direction. Results are shown to be in reasonable agreement with numerical solutions of the full KZK equation in both tissue and water for moderately nonlinear beams. JF - The Journal of the Acoustical Society of America AU - Soneson, Joshua E AU - Myers, Matthew R AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. joshua.soneson@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2526 EP - 2531 VL - 122 IS - 5 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Computer Simulation KW - Humans KW - Algorithms KW - Normal Distribution KW - Ultrasonic Therapy KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Gaussian+representation+of+high-intensity+focused+ultrasound+beams.&rft.au=Soneson%2C+Joshua+E%3BMyers%2C+Matthew+R&rft.aulast=Soneson&rft.aufirst=Joshua&rft.date=2007-11-01&rft.volume=122&rft.issue=5&rft.spage=2526&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept. AN - 69086657; 18161245 AB - This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm. JF - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine AU - Dong, R G AU - Welcome, D E AU - Wu, J Z AD - Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-2027, Morgantown, WV 26505, USA. rkd6@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 847 EP - 861 VL - 221 IS - 8 SN - 0954-4119, 0954-4119 KW - Index Medicus KW - Hand-Arm Vibration Syndrome -- physiopathology KW - Computer Simulation KW - Vibration KW - Stress, Mechanical KW - Humans KW - Energy Transfer -- physiology KW - Hand -- physiology KW - Movement -- physiology KW - Environmental Exposure -- analysis KW - Models, Biological KW - Biomechanical Phenomena -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Institution+of+Mechanical+Engineers.+Part+H%2C+Journal+of+engineering+in+medicine&rft.atitle=A+method+to+quantify+hand-transmitted+vibration+exposure+based+on+the+biodynamic+stress+concept.&rft.au=Dong%2C+R+G%3BWelcome%2C+D+E%3BWu%2C+J+Z&rft.aulast=Dong&rft.aufirst=R&rft.date=2007-11-01&rft.volume=221&rft.issue=8&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Institution+of+Mechanical+Engineers.+Part+H%2C+Journal+of+engineering+in+medicine&rft.issn=09544119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma. AN - 69062390; 18077994 AB - On May 17, 2007, doxorubicin HCl liposome injection (Doxil) in combination with bortezomib (Velcade) received approval from the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple myeloma after at least one prior therapy that has not included bortezomib. Liposomal doxorubicin's efficacy and safety were demonstrated in a phase III, randomized, multicenter, international trial comparing the combination of this agent plus bortezomib vs bortezomib alone in multiple myeloma patients who had not previously received bortezomib and had received at least one prior therapy. Here we summarize the FDA review of the data that support this approval. An interim analysis of time to disease progression (TTP), the primary endpoint, was conducted after 249 TTP events in this study that randomized 324 patients to liposomal doxorubicin plus bortezomib treatment and 322 patients to bortezomib monotherapy. Time to progression was significantly prolonged in the combination arm (median TTP = 9.3 months) compared with bortezomib monotherapy (median TTP = 6.5 months), P < .0001 (log-rank test); hazard ratio = 0.55 (95% confidence interval = 0.43-0.71). The response rates were similar between the two arms and not statistically different; however, among responding patients, the median duration of response was longer with the combination--10.2 months compared to 7.0 months in the monotherapy arm. Adverse reactions occurred more frequently with the combination therapy. As compared to the monotherapy, frequent grade 3/4 adverse reactions with the combination were neutropenia and thrombocytopenia. Liposomal doxorubicin received FDA approval for use in combination with bortezomib in patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy. JF - Oncology (Williston Park, N.Y.) AU - Ning, Yang-Min AU - He, Kun AU - Dagher, Ramzi AU - Sridhara, Rajeshwari AU - Farrell, Ann T AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration Silver Spring, Maryland 20993-0004, USA. ningy@cder.fda.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1503 EP - 8; discussion 1511, 1513, 1516 passim VL - 21 IS - 12 SN - 0890-9091, 0890-9091 KW - Antibiotics, Antineoplastic KW - 0 KW - Boronic Acids KW - Pyrazines KW - Bortezomib KW - 69G8BD63PP KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - United States KW - Humans KW - Salvage Therapy KW - Disease Progression KW - Aged KW - Kaplan-Meier Estimate KW - Aged, 80 and over KW - Drug Approval KW - Adult KW - Middle Aged KW - Female KW - Male KW - Doxorubicin -- adverse effects KW - Neoplasm Recurrence, Local -- drug therapy KW - Pyrazines -- therapeutic use KW - Multiple Myeloma -- drug therapy KW - Doxorubicin -- therapeutic use KW - Boronic Acids -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Boronic Acids -- therapeutic use KW - Pyrazines -- adverse effects KW - Antibiotics, Antineoplastic -- adverse effects KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69062390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Liposomal+doxorubicin+in+combination+with+bortezomib+for+relapsed+or+refractory+multiple+myeloma.&rft.au=Ning%2C+Yang-Min%3BHe%2C+Kun%3BDagher%2C+Ramzi%3BSridhara%2C+Rajeshwari%3BFarrell%2C+Ann+T%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Ning&rft.aufirst=Yang-Min&rft.date=2007-11-01&rft.volume=21&rft.issue=12&rft.spage=1503&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Noise exposures during potato processing and manufacture of animal feed. AN - 69059213; 18075013 AB - A noise exposure survey was conducted at an agricultural facility to evaluate noise exposures during potato processing and during the manufacture of alfalfa pellets. Of the 19 employees monitored, five reached or exceeded the National Institute for Occupational Safety and Health recommended exposure limit for occupational noise. Four of these employees were from the potato processing area, and one was from the alfalfa pellet-mill operation. Two of the five (bagger and pellet-mill operator) also exceeded the Occupational Safety and Health Administration action level. The facility has a well-managed hearing conservation program for employees in the potato processing area, but not in the alfalfa manufacturing area. JF - Journal of agricultural safety and health AU - Achutan, C AU - Tubbs, R L AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. cma4@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 367 EP - 374 VL - 13 IS - 4 SN - 1074-7583, 1074-7583 KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Ear Protective Devices KW - Solanum tuberosum KW - Humans KW - Medicago sativa KW - Animal Feed KW - Hearing Loss, Noise-Induced -- etiology KW - Agricultural Workers' Diseases -- prevention & control KW - Agricultural Workers' Diseases -- etiology KW - Hearing Loss, Noise-Induced -- prevention & control KW - Noise, Occupational -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69059213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=Noise+exposures+during+potato+processing+and+manufacture+of+animal+feed.&rft.au=Achutan%2C+C%3BTubbs%2C+R+L&rft.aulast=Achutan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=13&rft.issue=4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Agric Saf Health. 2008 Jan;14(1):table of contents N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a proposed area equation for improved exothermic process control. AN - 68522118; 17982158 AB - Our understanding of heat transfer and meteorological theories and their applications for engineering control design have been refined since the collective work in ventilation engineering for manufacturing process was published by Hemeon in 1955. These refined theories were reviewed and used to develop a newly proposed equation to estimate buoyant plume area (A). The area is a key parameter in estimating the plume volumetric flow (Q=UA) required for exothermic process control. Subsequent to developing a theoretical equation for plume area (A), plume velocity and area data were collected in the laboratory using a thermal anemometer and a scale-model exothermic process. Laboratory results were compared to solutions provided by the proposed, American Conference of Governmental Industrial Hygienists (ACGIH) and Hemeon plume area equations to determine which equation most closely matched the laboratory data. To make this determination, either t-tests or Wilcoxon signed-rank tests were conducted (based on examination of data normality) to determine the difference between collected data and solutions from the proposed, ACGIH and Hemeon equations. Median differences and P-values from Wilcoxon signed-rank tests (non-parametric) indicate that the ACGIH and Hemeon plume area equations provide significantly lower values than the laboratory data. However, the proposed equation provided solutions that were not significantly different from the collected data. Results indicate that the plume area equations currently recommended by the ACGIH and Hemeon are not as accurate as the proposed equation over the range of parameters investigated. JF - The Annals of occupational hygiene AU - McKernan, John L AU - Ellenbecker, Michael J AU - Holcroft, Christina A AU - Petersen, Martin R AD - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA. jmckernan@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 725 EP - 738 VL - 51 IS - 8 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Occupational Health KW - Equipment Design KW - Engineering KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Temperature KW - Occupational Exposure -- prevention & control KW - Ventilation -- instrumentation KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Evaluation+of+a+proposed+area+equation+for+improved+exothermic+process+control.&rft.au=McKernan%2C+John+L%3BEllenbecker%2C+Michael+J%3BHolcroft%2C+Christina+A%3BPetersen%2C+Martin+R&rft.aulast=McKernan&rft.aufirst=John&rft.date=2007-11-01&rft.volume=51&rft.issue=8&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-16 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of two DNA template preparation methods for post-immunomagnetic separation detection of Cryptosporidium parvum in foods and beverages by PCR. AN - 68487547; 17890339 AB - Cryptosporidium parvum oocysts were recovered by immunomagnetic separation from six artificially contaminated foods. Two DNA isolation methods were subsequently evaluated by PCR. The FTA Concentrator-PS filter provided rapid and reproducible detection, although variability increased at lower inoculum levels (88% and 15% detection in high- and low-inoculum-level samples, respectively). Total DNA extraction generated consistent results at all oocyst levels but resulted in longer analysis time (100% and 59% detection in high- and low-inoculum-level samples, respectively). Also reflected in this study was that the matrix played an important role in the ability to recover oocysts, as sample turbidity, pH, and PCR inhibitors all influenced detection. JF - Applied and environmental microbiology AU - Frazar, Christian D AU - Orlandi, Palmer A AD - Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 7474 EP - 7476 VL - 73 IS - 22 SN - 0099-2240, 0099-2240 KW - DNA, Protozoan KW - 0 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Hydrogen-Ion Concentration KW - Oocysts -- metabolism KW - Food Parasitology KW - Templates, Genetic KW - Oocysts -- growth & development KW - Immunomagnetic Separation -- methods KW - Cryptosporidium parvum -- isolation & purification KW - Beverages -- parasitology KW - Polymerase Chain Reaction -- methods KW - DNA, Protozoan -- genetics KW - Cryptosporidium parvum -- genetics KW - DNA, Protozoan -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68487547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Evaluation+of+two+DNA+template+preparation+methods+for+post-immunomagnetic+separation+detection+of+Cryptosporidium+parvum+in+foods+and+beverages+by+PCR.&rft.au=Frazar%2C+Christian+D%3BOrlandi%2C+Palmer+A&rft.aulast=Frazar&rft.aufirst=Christian&rft.date=2007-11-01&rft.volume=73&rft.issue=22&rft.spage=7474&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Food Microbiol. 2000 Mar 25;54(3):155-62 [10777065] MMWR Morb Mortal Wkly Rep. 2007 Mar 30;54(53):1-92 [17392681] Vet Parasitol. 2000 Nov 10;93(2):103-12 [11035228] J Clin Microbiol. 2000 Nov;38(11):3984-90 [11060056] Appl Environ Microbiol. 2001 Jun;67(6):2665-8 [11375178] J Food Prot. 2001 Nov;64(11):1793-8 [11726161] J Microbiol Methods. 2002 May;49(3):209-24 [11869786] J Food Prot. 2002 Aug;65(8):1345-8 [12182493] J Microbiol Methods. 2004 Sep;58(3):375-86 [15279942] MMWR Morb Mortal Wkly Rep. 1987 Aug 28;36(33):561-3 [3112550] Am J Trop Med Hyg. 1991 Dec;45(6):688-94 [1763795] N Engl J Med. 1994 Jul 21;331(3):161-7 [7818640] Int J Food Microbiol. 1996 Sep;32(1-2):1-26 [8880324] MMWR Morb Mortal Wkly Rep. 1997 Jan 10;46(1):4-8 [9011776] Appl Environ Microbiol. 1997 May;63(5):2029-37 [9143132] Am J Trop Med Hyg. 1997 Dec;57(6):683-6 [9430527] FEMS Immunol Med Microbiol. 1999 Mar;23(3):213-20 [10219593] Appl Environ Microbiol. 2005 Feb;71(2):898-903 [15691946] Foodborne Pathog Dis. 2004 Winter;1(4):216-22 [15992283] J Clin Microbiol. 2000 Jun;38(6):2271-7 [10834988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Haff disease after eating salmon. AN - 68481584; 17984750 AB - While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh water fish have rarely been reported in the United States but have been frequently reported from the Baltic region. This illness is known as Haff disease. While the etiology is unknown, it is felt to be a toxin. Palytoxin, found in marine fish, has been associated with rhabdomyolysis, and may serve as a model for further study of the suspected toxin responsible for rhabdomyolysis after consumption of fresh water fish. If a case of Haff disease is suspected, contact the Centers for Disease Control and Prevention and collect any uneaten fish, which may be sent for laboratory analysis. JF - Southern medical journal AU - Langley, Ricky L AU - Bobbitt, William H AD - North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA. rick.langley@ncmail.net Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1147 EP - 1150 VL - 100 IS - 11 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Diagnosis, Differential KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Salmon KW - Rhabdomyolysis -- etiology KW - Foodborne Diseases -- etiology KW - Foodborne Diseases -- diagnosis KW - Rhabdomyolysis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68481584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Haff+disease+after+eating+salmon.&rft.au=Langley%2C+Ricky+L%3BBobbitt%2C+William+H&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2007-11-01&rft.volume=100&rft.issue=11&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. AN - 68479251; 17945506 AB - Dependence on cocaine is still a main unresolved medical and social concern, and in spite of research efforts, no pharmacological therapy against cocaine dependence is yet available. Recent studies have shown that the endocannabinoid system participates in specific stages and aspects of drug dependence in general, and some of this evidence suggests an involvement of the cannabinoid system in cocaine effects. For example, cocaine administration has been shown to alter brain endocannabinoid levels, and the endocannabinoid system has been involved in long-term modifications of brain processes that might play a role in neuro/behavioral effects of psychostimulant drugs like cocaine. Human studies show that marijuana dependence is frequently associated with cocaine dependence, and that the cannabinoid receptor CNR1 gene polymorphism might be related to cocaine addiction. This article will review the main papers in the field showing how a modulation of different components of the cannabinoid system might interact with some of the neurobiological/behavioral effects of cocaine related to its reinforcing effects, evaluated in preclinical models or in clinical settings. The goal of this review will be to provide insights into the complex picture of cocaine abuse and addiction, and to extrapolate from such endocannabinoid-cocaine interactions useful information to test the therapeutic potential of cannabinoid ligands and endocannabinoid-level enhancers against cocaine dependence for future preclinical/clinical trials. JF - Pharmacological research AU - Tanda, Gianluigi AD - Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. gtanda@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 406 EP - 417 VL - 56 IS - 5 SN - 1043-6618, 1043-6618 KW - Cannabinoid Receptor Modulators KW - 0 KW - Central Nervous System Agents KW - Endocannabinoids KW - Index Medicus KW - Animals KW - Humans KW - Cannabinoid Receptor Modulators -- metabolism KW - Cocaine-Related Disorders -- drug therapy KW - Central Nervous System Agents -- therapeutic use KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68479251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=Modulation+of+the+endocannabinoid+system%3A+therapeutic+potential+against+cocaine+dependence.&rft.au=Tanda%2C+Gianluigi&rft.aulast=Tanda&rft.aufirst=Gianluigi&rft.date=2007-11-01&rft.volume=56&rft.issue=5&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=10436618&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Biobehav Rev. 2004 Jan;27(8):813-20 [15019430] Mol Psychiatry. 2004 Oct;9(10):916-31 [15289816] Int J Addict. 1972;7(1):27-55 [5043838] J Pharmacol Exp Ther. 1975 Jul;194(1):74-81 [168349] Mol Pharmacol. 1976 May;12(3):345-52 [934055] Eur J Pharmacol. 1976 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Nov-Dec;58(6):806-19 [17220538] J Neurosci. 2007 Jan 24;27(4):791-5 [17251418] Neuropsychopharmacology. 2007 Mar;32(3):646-57 [16738542] J Pharmacol Exp Ther. 2007 Apr;321(1):370-80 [17210800] J Pharmacol Exp Ther. 2007 Apr;321(1):334-44 [17255465] Science. 1997 Oct 3;278(5335):52-8 [9311926] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contact lens safety and the FDA: 1976 to the present. AN - 68462414; 17975433 AB - The U.S. Food and Drug Administration (FDA) performs many different functions to fulfill its responsibility of regulating medical devices. The various roles in premarket and postmarket safety are discussed with representative historic events involving the regulation of contact lenses and lens care products. Current challenges facing the contact lens industry to maintain safe use of these medical devices are explained, and future pathways to address these challenges are considered. JF - Eye & contact lens AU - Saviola, James F AD - Office of Device Evaluation, Division of Ophthalmic and Ear, Nose, and Throat Devices, Center for Divices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20850, USA. james.saviola@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 404 EP - 9; discussion 410-1 VL - 33 IS - 6 Pt 2 SN - 1542-2321, 1542-2321 KW - Contact Lens Solutions KW - 0 KW - Index Medicus KW - United States KW - Information Dissemination -- methods KW - Consumer Product Safety KW - Contact Lens Solutions -- adverse effects KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Equipment Safety KW - Internet KW - United States Food and Drug Administration -- trends KW - Contact Lenses -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68462414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eye+%26+contact+lens&rft.atitle=Contact+lens+safety+and+the+FDA%3A+1976+to+the+present.&rft.au=Saviola%2C+James+F&rft.aulast=Saviola&rft.aufirst=James&rft.date=2007-11-01&rft.volume=33&rft.issue=6+Pt+2&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Eye+%26+contact+lens&rft.issn=15422321&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Portable XRF analysis of occupational air filter samples from different workplaces using different samplers: final results, summary and conclusions. AN - 68449743; 17968454 AB - This paper concludes a five-year program on research into the use of a portable X-ray fluorescence (XRF) analyzer for analyzing lead in air sampling filters from different industrial environments, including mining, manufacturing and recycling. The results from four of these environments have already been reported. The results from two additional metal processes are presented here. At both of these sites, lead was a minor component of the total airborne metals and interferences from other elements were minimal. Nevertheless, only results from the three sites where lead was the most abundant metal were used in the overall calculation of method accuracy. The XRF analyzer was used to interrogate the filters, which were then subjected to acid digestion and analysis by inductively-coupled plasma optical-emission spectroscopy (ICP-OES). The filter samples were collected using different filter-holders or "samplers" where the size (diameter), depth and homogeneity of aerosol deposit varied from sampler to sampler. The aerosol collection efficiencies of the samplers were expected to differ, especially for larger particles. The distribution of particles once having entered the sampler was also expected to differ between samplers. Samplers were paired to allow the between-sampler variability to be addressed, and, in some cases, internal sampler wall deposits were evaluated and compared to the filter catch. It was found, rather surprisingly, that analysis of the filter deposits (by ICP-OES) of all the samplers gave equivalent results. It was also found that deposits on some of the sampler walls, which in some protocols are considered part of the sample, could be significant in comparison to the filter deposit. If it is concluded that wall-deposits should be analyzed, then XRF analysis of the filter can only give a minimum estimate of the concentration. Techniques for the statistical analysis of field data were also developed as part of this program and have been reported elsewhere. The results, based on data from the three workplaces where lead was the major element present in the samples, are summarized here. A limit of detection and a limit of quantitation are provided. Analysis of some samples using a second analyzer with a different X-ray source technology indicated reasonable agreement for some metals (but this was not evaluated for lead). Provided it is only necessary to analyze the filters, most personal samplers will provide acceptable results when used with portable XRF analysis for lead around applicable limit values. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Pacolay, Bruce AU - Hintz, Patrick AU - Bartley, David L AU - Slaven, James E AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1263 EP - 1270 VL - 9 IS - 11 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Metals KW - Index Medicus KW - Fluorescence KW - Filtration -- instrumentation KW - Metals -- analysis KW - Occupational Exposure KW - Spectrometry, X-Ray Emission -- methods KW - Air Pollutants, Occupational -- analysis KW - Workplace UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68449743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Portable+XRF+analysis+of+occupational+air+filter+samples+from+different+workplaces+using+different+samplers%3A+final+results%2C+summary+and+conclusions.&rft.au=Harper%2C+Martin%3BPacolay%2C+Bruce%3BHintz%2C+Patrick%3BBartley%2C+David+L%3BSlaven%2C+James+E%3BAndrew%2C+Michael+E&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=1263&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a field method for measuring manganese in welding fume. AN - 68446802; 17968446 AB - Workers who perform routine welding tasks are potentially exposed to fume that may contain manganese. Manganese may cause respiratory problems and is implicated in causing the occurrence of Parkinson-like symptoms. In this study, a field colorimetric method for extracting and measuring manganese in welding fume was developed. The method uses ultrasonic extraction with an acidic hydrogen peroxide solution to extract welding fume collected on polyvinyl chloride filters. Commercially available pre-packaged reagents are used to produce a colored solution, created by a reaction of manganese(ii) with 1-(2-pyridylazo)-2-naphthol. Absorbance measurements are then made using a portable spectrophotometer. The method detection limit and limit of quantification (LOQ) were 5.2 microg filter(-1) and 17 microg filter(-1), respectively, with a dynamic range up to 400 microg filter(-1). When the results are above the LOQ for the colorimetric method, the manganese masses are equivalent to those measured by the International Organization for Standardization Method 15202-2, which employs a strong acid digestion and analysis using inductively coupled plasma-optical emission spectrometry. JF - Journal of environmental monitoring : JEM AU - Dale Marcy, A AU - Drake, Pamela L AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave, Spokane, WA 99207, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1199 EP - 1204 VL - 9 IS - 11 SN - 1464-0325, 1464-0325 KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Sensitivity and Specificity KW - Occupational Exposure KW - Humans KW - Colorimetry KW - Manganese -- analysis KW - Welding KW - Spectrophotometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68446802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Development+of+a+field+method+for+measuring+manganese+in+welding+fume.&rft.au=Dale+Marcy%2C+A%3BDrake%2C+Pamela+L&rft.aulast=Dale+Marcy&rft.aufirst=A&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=1199&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticide dose estimates for children of Iowa farmers and non-farmers. AN - 68368426; 17659274 AB - Farm children have the potential to be exposed to pesticides. Biological monitoring is often employed to assess this exposure; however, the significance of the exposure is uncertain unless doses are estimated. In the spring and summer of 2001, 118 children (66 farm, 52 non-farm) of Iowa farm and non-farm households were recruited to participate in a study investigating potential take-home pesticide exposure. Each child provided an evening and morning urine sample at two visits spaced approximately 1 month apart, with the first sample collection taken within a few days after pesticide application. Estimated doses were calculated for atrazine, metolachlor, chlorpyrifos, and glyphosate from urinary metabolite concentrations derived from the spot urine samples and compared to EPA reference doses. For all pesticides except glyphosate, the doses from farm children were higher than doses from the non-farm children. The difference was statistically significant for atrazine (p<0.0001) but only marginally significant for chlorpyrifos and metolachlor (p = 0.07 and 0.1, respectively). Among farm children, geometric mean doses were higher for children on farms where a particular pesticide was applied compared to farms where that pesticide was not applied for all pesticides except glyphosate; results were significant for atrazine (p = 0.030) and metolachlor (p = 0.042), and marginally significant for chlorpyrifos (p = 0.057). The highest estimated doses for atrazine, chlorpyrifos, metolachlor, and glyphosate were 0.085, 1.96, 3.16, and 0.34 microg/kg/day, respectively. None of the doses exceeded any of the EPA reference values for atrazine, metolachlor, and glyphosate; however, all of the doses for chlorpyrifos exceeded the EPA chronic population adjusted reference value. Doses were similar for male and female children. A trend of decreasing dose with increasing age was observed for chlorpyrifos. JF - Environmental research AU - Curwin, Brian D AU - Hein, Misty J AU - Sanderson, Wayne T AU - Striley, Cynthia AU - Heederik, Dick AU - Kromhout, Hans AU - Reynolds, Stephen J AU - Alavanja, Michael C AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226, USA. bcurwin@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 307 EP - 315 VL - 105 IS - 3 SN - 0013-9351, 0013-9351 KW - Acetamides KW - 0 KW - Environmental Pollutants KW - Pesticides KW - glyphosate KW - 4632WW1X5A KW - Chlorpyrifos KW - JCS58I644W KW - Atrazine KW - QJA9M5H4IM KW - Glycine KW - TE7660XO1C KW - metolachlor KW - X0I01K05X2 KW - Index Medicus KW - Reference Values KW - Humans KW - Child KW - Glycine -- analogs & derivatives KW - Iowa KW - Child, Preschool KW - Acetamides -- urine KW - Atrazine -- urine KW - Case-Control Studies KW - Glycine -- urine KW - Urinalysis KW - Adolescent KW - Male KW - Female KW - Chlorpyrifos -- urine KW - Pesticides -- analysis KW - Agriculture -- methods KW - Pesticides -- urine KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- urine KW - Environmental Exposure -- adverse effects KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Pesticide+dose+estimates+for+children+of+Iowa+farmers+and+non-farmers.&rft.au=Curwin%2C+Brian+D%3BHein%2C+Misty+J%3BSanderson%2C+Wayne+T%3BStriley%2C+Cynthia%3BHeederik%2C+Dick%3BKromhout%2C+Hans%3BReynolds%2C+Stephen+J%3BAlavanja%2C+Michael+C&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2007-11-01&rft.volume=105&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Malathion exposure and the incidence of cancer in the agricultural health study. AN - 68364044; 17720683 AB - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance. JF - American journal of epidemiology AU - Bonner, Matthew R AU - Coble, Joseph AU - Blair, Aaron AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1023 EP - 1034 VL - 166 IS - 9 SN - 0002-9262, 0002-9262 KW - Insecticides KW - 0 KW - Malathion KW - U5N7SU872W KW - Index Medicus KW - Agriculture KW - Odds Ratio KW - Prospective Studies KW - International Classification of Diseases KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Confidence Intervals KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Insecticides -- adverse effects KW - Malathion -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- chemically induced KW - Agricultural Workers' Diseases -- chemically induced KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Malathion+exposure+and+the+incidence+of+cancer+in+the+agricultural+health+study.&rft.au=Bonner%2C+Matthew+R%3BCoble%2C+Joseph%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2007-11-01&rft.volume=166&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukemia following breast cancer: an international population-based study of 376,825 women. AN - 68328672; 17221155 AB - To quantify long-term temporal trends in the excess absolute risk (EAR) of secondary leukemia among breast cancer (BC) survivors, using multivariate analyses to evaluate the effects of subtype, age at BC diagnosis, attained age, and calendar year. We identified 376,825 1-year survivors of BC within 4 nationwide, population-based cancer registries in Sweden, Denmark, Finland, and Norway (1943-2001). Estimates of EAR (per 100,000 person-years) were modeled using Poisson regression methods and cumulative risks calculated using a competing risk model. A total of 687 non-chronic lymphocytic leukemias (EAR = 9.05; 95% confidence interval (CI) = 7.5-10.7) was reported. Significantly elevated risks were observed for the first time for chronic myeloid leukemia (CML) (EAR = 2.06; 95% CI = 1.3-2.9) and acute lymphoblastic leukemia (ALL) (EAR = 0.62; 95% CI = 0.2-1.1), in addition to acute myeloid leukemia (AML) (EAR = 5.00; 95% CI = 3.9-6.2). Excesses of CML, ALL, AML and all leukemias combined persisted over 25 years after BC diagnosis. For all leukemias, EAR decreased with increasing calendar year (P = 0.04) of BC diagnosis. Risk for all leukemia and AML by calendar year of BC diagnosis depended on age at diagnosis. For women diagnosed with BC after 1985, the 10-year cumulative risk of leukemia for those diagnosed before and after age 50 was small, 0.10% and 0.14%, respectively. Although secondary leukemia is a rare event, BC survivors experience statistically significant excesses for at least 25 years after diagnosis, including CML and ALL. Decreasing leukemia risks in recent calendar years likely reflect changes in treatment. JF - Breast cancer research and treatment AU - Howard, Regan A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Hall, Per AU - Storm, Hans AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Executive Plaza South, Suite 7091, Bethesda, MD 20892, USA. reganho@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 359 EP - 368 VL - 105 IS - 3 SN - 0167-6806, 0167-6806 KW - Index Medicus KW - Leukemia, Radiation-Induced -- epidemiology KW - Aged, 80 and over KW - Risk Factors KW - Leukemia, Radiation-Induced -- complications KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Leukemia, Radiation-Induced -- diagnosis KW - Female KW - Neoplasms, Second Primary -- complications KW - Leukemia -- diagnosis KW - Neoplasms, Second Primary -- epidemiology KW - Breast Neoplasms -- diagnosis KW - Leukemia -- epidemiology KW - Neoplasms, Second Primary -- diagnosis KW - Leukemia -- complications KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68328672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Leukemia+following+breast+cancer%3A+an+international+population-based+study+of+376%2C825+women.&rft.au=Howard%2C+Regan+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BHall%2C+Per%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2007-11-01&rft.volume=105&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-09 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Perceptions of Americans and the Iraq Invasion: Implications for Understanding National Character Stereotypes AN - 57231745; 200809432 AB - This study examines perceptions of the 'typical American' from 49 cultures around the world. Contrary to the ethnocentric bias hypothesis, a strong agreement was found between in-group and out-group ratings on the American profile (assertive, open-minded, but antagonistic). In fact, Americans had a somewhat less desirable view of Americans than did others. Within cultures, in-group ratings were not systematically more favorable than out-group ratings. The Iraq invasion had a slight negative effect on perceptions of the typical American, but people around the world seem to draw a clear distinction between U.S. foreign policy and the character of the American people. National character stereotypes appear to have a variety of sources and to be perpetuated by both cognitive mechanisms and sociocultural forces. [Reprinted by permission of Sage Publications Inc., copyright 2007.] JF - Journal of Cross-Cultural Psychology AU - Terracciano, Antonio AU - McCrae, Robert R AD - National Institute on Aging, National Institutes of Health, Department of Health and Human Services terraccianoa@grc.nia.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 695 EP - 710 PB - Sage Publications, Thousand Oaks VL - 38 IS - 6 SN - 0022-0221, 0022-0221 KW - Foreign policy KW - American people KW - Perceptions KW - Wars KW - National identity KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Perceptions+of+Americans+and+the+Iraq+Invasion%3A+Implications+for+Understanding+National+Character+Stereotypes&rft.au=Terracciano%2C+Antonio%3BMcCrae%2C+Robert+R&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2007-11-01&rft.volume=38&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022107308586 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - National identity; Wars; Perceptions; American people; Stereotypes; Foreign policy DO - http://dx.doi.org/10.1177/0022022107308586 ER - TY - JOUR T1 - Assessment, Authorization and Access to Medicaid Managed Mental Health Care AN - 57218660; 200804663 AB - Examined were effects on access of managed care assessment and authorization processes in California's 57 county mental health plans. Primary data on managed care implementation were collected from surveys of county plan administrators; secondary data were from Medicaid claims and enrollment files. Using multivariate fixed effects regression, we found that following implementation of managed care, greater access occurred in county plans where assessments and treatment were performed by the same clinician, and where service authorizations were made more rapidly. Lower access occurred in county plans where treating clinicians authorized services themselves. Results confirm the significant effects of managed care processes on outcomes and highlight the importance of system capacity. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Masland, Mary C AU - Snowden, Lonnie R AU - Wallace, Neal T AD - Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, 2140 Shattuck Ave, #409, Berkeley, CA 94720-1414, USA mmasland@berkeley.edu Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 548 EP - 562 PB - Springer, Dordrecht The Netherlands VL - 34 IS - 6 SN - 0894-587X, 0894-587X KW - Assessment KW - Managed care KW - Managed mental health care KW - Enrollment KW - Medicaid KW - Access KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57218660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Assessment%2C+Authorization+and+Access+to+Medicaid+Managed+Mental+Health+Care&rft.au=Masland%2C+Mary+C%3BSnowden%2C+Lonnie+R%3BWallace%2C+Neal+T&rft.aulast=Masland&rft.aufirst=Mary&rft.date=2007-11-01&rft.volume=34&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0138-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Managed care; Assessment; Access; Medicaid; Enrollment; Managed mental health care DO - http://dx.doi.org/10.1007/s10488-007-0138-7 ER - TY - JOUR T1 - Development and application of reservoir models and artificial neural networks for optimizing ventilation air requirements in development mining of coal seams AN - 51244734; 2008-069547 AB - In longwall development mining of coal seams, planning, optimizing and providing adequate ventilation are very important steps to eliminate the accumulation of explosive methane-air mixtures in the working environment. Mine operators usually try to supply maximum ventilation air based on the capacity of the system and the predicted need underground. This approach is neither economical nor safer as ventilation capacity may decrease in time depending on various mining and coalbed parameters. Thus, it is important to develop better engineered approaches to optimize mine ventilation effectiveness and, therefore, to ensure a safer work environment. This study presents an approach using coalbed methane reservoir modeling and an artificial neural network (ANN) design for prediction and optimization of methane inflows and ventilation air requirements to maintain methane concentrations below statutory limits. A coalbed reservoir model of a three-entry development section, which is typical of Pittsburgh Coalbed mines in the Southwestern Pennsylvania section of Northern Appalachian Basin, was developed taking into account the presence and absence of shielding boreholes around the entries against methane inflow. In the model, grids were dynamically controlled to simulate the advance of mining for parametric simulations. Development and application of artificial neural networks as an optimization tool for ventilation requirements are introduced. Model predictions are used to develop, train, and test artificial neural networks to optimize ventilation requirements. The sensitivity and applications of proposed networks for predicting simulator data are presented and discussed. Results show that reservoir simulations and integrated ANN models can be practical and powerful tools for predicting methane emissions and optimization of ventilation air requirements. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 221 EP - 239 PB - Elsevier, Amsterdam VL - 72 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - North America KW - mining KW - mines KW - numerical models KW - underground mining KW - natural gas KW - coal mines KW - optimization KW - Appalachians KW - petroleum KW - coal seams KW - reservoir rocks KW - ventilation KW - artificial intelligence KW - boreholes KW - Appalachian Basin KW - coalbed methane KW - applications KW - neural networks KW - Pennsylvania KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51244734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Development+and+application+of+reservoir+models+and+artificial+neural+networks+for+optimizing+ventilation+air+requirements+in+development+mining+of+coal+seams&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=72&rft.issue=3-4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.02.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Appalachian Basin; Appalachians; applications; artificial intelligence; boreholes; coal mines; coal seams; coalbed methane; mines; mining; natural gas; neural networks; North America; numerical models; optimization; Pennsylvania; petroleum; reservoir rocks; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2007.02.003 ER - TY - JOUR T1 - Swelling-induced volumetric strains internal to a stressed coal associated with CO (sub 2) sorption AN - 51244710; 2008-069546 AB - It is generally accepted that typical coalbed gases (methane and carbon dioxide) are sorbed (both adsorbed and absorbed) in the coal matrix causing it to swell and resulting in local stress and strain variations in a coalbed confined under overburden pressure. The swelling, interactions of gases within the coal matrix and the resultant changes in the permeability, sorption, gas flow mechanics in the reservoir, and stress state of the coal can impact a number of reservoir-related factors. These include effective production of coalbed methane, degasification of future mining areas by drilling horizontal and vertical degasification wells, injection of CO (sub 2) as an enhanced coalbed methane recovery technique, and concurrent CO (sub 2) sequestration. Such information can also provide an understanding of the mechanisms behind gas outbursts in underground coal mines. The spatio-temporal volumetric strains in a consolidated Pittsburgh seam coal sample were evaluated while both confining pressure and carbon dioxide (CO (sub 2) ) pore pressure were increased to keep a constant positive effective stress on the sample. The changes internal to the sample were evaluated by maps of density and atomic number determined by dual-energy X-ray computed tomography (X-ray CT). Early-time images, as soon as CO (sub 2) was introduced, were also used to calculate the macroporosity in the coal sample. Scanning electron microscopy (SEM) and photographic images of the polished section of the coal sample at X-ray CT image location were used to identify the microlithotypes and microstructures. The CO (sub 2) sorption-associated swelling and volumetric strains in consolidated coal under constant effective stress are heterogeneous processes depending on the lithotypes present. In the time scale of the experiment, vitrite showed the highest degree of swelling due to dissolution of CO (sub 2) , while the clay (kaolinite) and inertite region was compressed in response. The volumetric strains associated with swelling and compression were between + or -15% depending on the location. Although the effective stress on the sample was constant, it varied within the sample as a result of the internal stresses created by gas sorption-related structural changes. SEM images and porosity calculations revealed that the kaolinite and inertite bearing layer was highly porous, which enabled the fastest CO (sub 2) uptake and the highest degree of compression. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 209 EP - 220 PB - Elsevier, Amsterdam VL - 72 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - silicates KW - horizontal drilling KW - sorption KW - Pittsburgh Coal KW - strain KW - Pennsylvanian KW - natural gas KW - petroleum KW - carbon dioxide KW - sedimentary rocks KW - coal KW - directional drilling KW - drilling KW - degassing KW - mines KW - inertite KW - carbon sequestration KW - Paleozoic KW - stress KW - coal mines KW - Carboniferous KW - kaolinite KW - recovery KW - gases KW - clay minerals KW - X-ray data KW - volume KW - coalbed methane KW - petrography KW - sheet silicates KW - Pennsylvania KW - computed tomography data KW - SEM data KW - 29A:Economic geology, geology of energy sources KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51244710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Swelling-induced+volumetric+strains+internal+to+a+stressed+coal+associated+with+CO+%28sub+2%29+sorption&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=72&rft.issue=3-4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.01.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 31 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; Carboniferous; clay minerals; coal; coal mines; coalbed methane; computed tomography data; degassing; directional drilling; drilling; gases; horizontal drilling; inertite; kaolinite; mines; natural gas; Paleozoic; Pennsylvania; Pennsylvanian; petrography; petroleum; Pittsburgh Coal; recovery; sedimentary rocks; SEM data; sheet silicates; silicates; sorption; strain; stress; United States; volume; X-ray data DO - http://dx.doi.org/10.1016/j.coal.2007.01.003 ER - TY - JOUR T1 - Methods for determining roof fall risk in underground mines AN - 51017188; 2008-088171 AB - Reducing the number of roof fall injuries is a goal of the NIOSH mine safety research program. Central to this effort is the development of assessment techniques to help identify the nature of the risks associated with working under potentially hazardous roof conditions. This paper discusses a method to determine the roof fall risk using a qualitative risk-analysis technique. The ability to determine roof fall risk has been a long-standing goal of safety professionals and could provide the kind of information needed by on-site personnel responsible for worker safety to mitigate roof fall injuries. JF - Mining Engineering AU - Iannacchione, A AU - Prosser, I AU - Esterhuizen, G AU - Bajpayee, T Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 47 EP - 53 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 59 IS - 11 SN - 0026-5187, 0026-5187 KW - mining KW - mines KW - monitoring KW - geologic hazards KW - underground mining KW - roof control KW - statistical analysis KW - prediction KW - standardization KW - safety KW - risk assessment KW - probability KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51017188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Methods+for+determining+roof+fall+risk+in+underground+mines&rft.au=Iannacchione%2C+A%3BProsser%2C+I%3BEsterhuizen%2C+G%3BBajpayee%2C+T&rft.aulast=Iannacchione&rft.aufirst=A&rft.date=2007-11-01&rft.volume=59&rft.issue=11&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ L2 - http://me.smenet.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 19 N1 - PubXState - CO N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - MIENAB N1 - SubjectsTermNotLitGenreText - geologic hazards; mines; mining; monitoring; prediction; probability; risk assessment; roof control; safety; standardization; statistical analysis; underground mining ER - TY - JOUR T1 - Outcomes of a randomized trial of continuum of care services for children in a child welfare system AN - 37023345; 3803945 AB - The Connecticut Department of Children and Families Title IV-E waiver demonstration evaluated whether the well-being of children approved for residential mental health services could be improved, and lengths of stay in restrictive placements reduced, by providing case rate payments to community agencies to provide continuum of care services. Children between ages 7 and 15 were randomly assigned to either the demonstration group (n = 78) or to usual state-supported services (n = 79). One-year outcome results indicated that in a situation that is less costly, improvement in outcomes occurred in less restrictive settings. Continuum of care services were more effective in 1) returning children to in-home placements, 2) reducing the length of stay in restrictive placements, and (3) utilizing higher levels of case management through coordination among agencies and family support services. © (2007) Child Welfare League of America. Reprinted by permission JF - Child welfare AU - Holden, E Wayne AU - O'Connell, Susan Rousseau AU - Liao, Qinghong AU - Krivelyova, Anna AU - Connor, Tim AU - Blau, Gary M AU - Long, Dorian AD - RTI International ; Community Health Resources, Connecticut ; MACRO International, Atlanta ; University of Wisconsin ; US Substance Abuse and Mental Health Services Administration Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 89 EP - 114 VL - 86 IS - 6 SN - 0009-4021, 0009-4021 KW - Sociology KW - U.S.A. KW - Evaluation KW - Family policy KW - Surveys KW - Mental health KW - Social policy KW - Child care KW - Connecticut KW - Child welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37023345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=Outcomes+of+a+randomized+trial+of+continuum+of+care+services+for+children+in+a+child+welfare+system&rft.au=Holden%2C+E+Wayne%3BO%27Connell%2C+Susan+Rousseau%3BLiao%2C+Qinghong%3BKrivelyova%2C+Anna%3BConnor%2C+Tim%3BBlau%2C+Gary+M%3BLong%2C+Dorian&rft.aulast=Holden&rft.aufirst=E&rft.date=2007-11-01&rft.volume=86&rft.issue=6&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7947 5772 7954; 4774 9874 5574 10472 11888; 12429; 4551; 2192; 2208 2212; 11888 10472; 97 433 293 14 ER - TY - JOUR T1 - The joint demand for health care, leisure, and commodities: implications for health care finance and access in Vietnam AN - 36816820; 3499886 AB - This paper explores linkages between the demand for health care providers and the consumption of food, non-food goods, and leisure in Vietnam, using a mixed continuous/discrete dependent variable model. Cross-price elasticities calculated from the model suggest there are strong substitution effects between health care, leisure, and certain commodities. The model allows us to explore the implications of replacing user fees with alternative forms of health care finance, such as commodity taxes. In particular, the results suggest financing public health care services with a non-food sales tax rather than user fees would be more progressive and would improve access to care. Reprinted by permission of Frank Cass & Co. Ltd. JF - Journal of development studies AU - Meyerhoefer, Chad D AU - Sahn, David E AU - Younger, Stephen D AD - Agency for Healthcare Research and Quality ; Cornell University Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1475 EP - 1500 VL - 43 IS - 8 SN - 0022-0388, 0022-0388 KW - Sociology KW - Health economics KW - Health care KW - Development studies KW - Leisure KW - Health services KW - Commodities KW - Vietnam KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+development+studies&rft.atitle=The+joint+demand+for+health+care%2C+leisure%2C+and+commodities%3A+implications+for+health+care+finance+and+access+in+Vietnam&rft.au=Meyerhoefer%2C+Chad+D%3BSahn%2C+David+E%3BYounger%2C+Stephen+D&rft.aulast=Meyerhoefer&rft.aufirst=Chad&rft.date=2007-11-01&rft.volume=43&rft.issue=8&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=Journal+of+development+studies&rft.issn=00220388&rft_id=info:doi/10.1080%2F00220380701611527 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5775 13521; 7336 3198; 2547 3996; 5778 4025; 5792 10484; 10449 5772; 3513; 449 393 30 DO - http://dx.doi.org/10.1080/00220380701611527 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS: STUDIES OF [alpha]-METHYLSTYRENE (CAS NO. 98-83-9) IN F344/N RATS AND B6C3F^sub 1^ MICE (INHALATION STUDIES) AN - 236521020; 18685715 AB - α-Methylstyrene is used to make heat-resistant acrylonitrile-butathene-styrene resins and polymers. We studied the effects of a-methylstyrene on male and female rats and mice to identify potential toxic or cancer-related hazards. We exposed groups of 50 male and female rats to atmospheres containing 100, 300, or 1,000 parts per million (ppm) of a-methylstyrene 6 hours per day, 5 days a week for 2 years. Groups of 50 male and female mice were similarly exposed to atmospheres containing 100, 300, or 600 ppm a-methylstyrene. Control animals were housed in exposure chambers for similar periods but with no test chemical in their air. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival was similar for animals receiving a-methylstyrene and the controls, but the average body weight for each animal group receiving the highest concentration of a-methylstyrene was less than that for the control group. Male rats exposed to a-methylstyrene had increased rates of tumors of the kidney and a slightly increased rate of mononuclear cell leukemia. Female mice exposed to a-methylstyrene had increased rates of a variety of liver cancers, and male mice also had slightly increased rates of liver tumors. We conclude that exposure to a-methylstyrene in the air caused kidney tumors, and possibly mononuclear cell leukemia, in male rats. We conclude that a-methylstyrene caused liver cancer in female mice, and also possibly in male mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1 EP - 210 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Air Pollutants, Occupational KW - Carcinogens KW - Mutagens KW - Styrenes KW - alpha-methylstyrol KW - Toxicology KW - Leukemia KW - Rodents KW - Kidney Neoplasms -- pathology KW - Animals KW - Kidney Neoplasms -- chemically induced KW - DNA Damage KW - Nose Diseases -- chemically induced KW - Mutagens -- administration & dosage KW - Neoplasms, Experimental -- pathology KW - Rats KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Styrenes -- administration & dosage KW - CHO Cells KW - Leukemia, Myeloid -- pathology KW - Male KW - Kidney -- pathology KW - Cricetulus KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Kidney -- drug effects KW - Liver Neoplasms -- chemically induced KW - Mice KW - Leukemia, Myeloid -- chemically induced KW - Mice, Inbred Strains KW - Inhalation Exposure KW - Body Weight -- drug effects KW - Female KW - Cricetinae KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Air Pollutants, Occupational -- toxicity KW - Styrenes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236521020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS%3A+STUDIES+OF+%5Balpha%5D-METHYLSTYRENE+%28CAS+NO.+98-83-9%29+IN+F344%2FN+RATS+AND+B6C3F%5Esub+1%5E+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236491904 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236491904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236445513 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236445513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Two Domains of Cytotoxic Necrotizing Factor Type 1 Bind the Cellular Receptor, Laminin Receptor Precursor Protein AN - 21008620; 7931944 AB - Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are highly homologous toxins that are produced by certain pathogenic strains of Escherichia coli. These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA, Rac1, and Cdc42 and consist of a putative N-terminal binding domain, a transmembrane region, and a C-terminal catalytic domain. To define the regions of CNF1 that are responsible for binding of the toxin to its cellular receptor, the laminin receptor precursor protein (LRP), a series of CNF1 truncated toxins were characterized and assessed for toxin binding. In particular, three truncated toxins, Delta N63, Delta N545, and Delta C469, retained conformational integrity and in vitro enzymatic activity and were immunologically reactive against a panel of anti-CNF1 monoclonal antibodies (MAbs). Based on a comparison of these truncated toxins with wild-type CNF1 and CNF2 in LRP and HEp-2 cell binding assays and in MAb and LRP competitive binding inhibition assays and based on the results of confocal microscopy, we concluded that CNF1 contains two major binding regions: one located within the N terminus, which contained amino acids 135 to 164, and one which resided in the C terminus and included amino acids 683 to 730. The data further indicate that CNF1 can bind to an additional receptor(s) on HEp-2 cells and that LRP can also serve as a cellular receptor for CNF2. JF - Infection and Immunity AU - McNichol, Beth A AU - Rasmussen, Susan B AU - Carvalho, Humberto M AU - Meysick, Karen C AU - O'Brien, Alison D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. FDA/CBER, Bethesda, Maryland 20892 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 5095 EP - 5104 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 11 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Glutamine KW - Amino acids KW - Data processing KW - Monoclonal antibodies KW - Rac1 protein KW - Cdc42 protein KW - laminin receptors KW - Toxins KW - RhoA protein KW - Cytotoxic necrotizing factor KW - Confocal microscopy KW - Escherichia coli KW - Enzymatic activity KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21008620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Two+Domains+of+Cytotoxic+Necrotizing+Factor+Type+1+Bind+the+Cellular+Receptor%2C+Laminin+Receptor+Precursor+Protein&rft.au=McNichol%2C+Beth+A%3BRasmussen%2C+Susan+B%3BCarvalho%2C+Humberto+M%3BMeysick%2C+Karen+C%3BO%27Brien%2C+Alison+D&rft.aulast=McNichol&rft.aufirst=Beth&rft.date=2007-11-01&rft.volume=75&rft.issue=11&rft.spage=5095&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Glutamine; Data processing; Amino acids; Monoclonal antibodies; Rac1 protein; Cytotoxic necrotizing factor; Confocal microscopy; Cdc42 protein; Enzymatic activity; laminin receptors; Toxins; RhoA protein; Escherichia coli ER - TY - JOUR T1 - Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks AN - 20891036; 8398077 AB - Retinyl esters account for more than 70% of the endogenous vitamin A found in human skin, and retinyl palmitate is one of the retinyl esters in this pool. Human skin is also exposed to retinyl palmitate exogenously through the topical application of cosmetic and skin care products that contain retinyl palmitate. To date, there is limited information on the penetration and distribution of retinyl palmitate and vitamin A within in the skin. In this study, the accumulation of retinyl palmitate and generation of retinol in the skin of male and female SKH-1 mice that received repeated topical applications of creams containing 0.0%, 0.1%, 0.5%, 1.0%, 5.0%, 10%, or 13% of retinyl palmitate 5 days a week for a period of 13 weeks were studied. Because products containing retinyl palmitate are frequently applied to sun-exposed skin, and because it is well established that exposure to sunlight and UV light can alter cutaneous levels of retinoids, mice in this study were additionally exposed 5 days a week to simulated solar light. The results showed that retinyl palmitate diffused into the skin and was partially hydrolyzed to retinol. The levels of retinyl palmitate in the skin of mice that were administered retinyl palmitate cream were higher than control values, and levels of both retinyl palmitate and retinol increased with the application of higher concentrations of retinyl palmitate in the cream. Our results indicate that topically applied retinyl palmitate may alter the normal physiological levels of retinyl palmitate and retinol in the skin of SKH-1 mice and may have a significant impact on vitamin A homeostasis in the skin. JF - Toxicology and Industrial Health AU - Yan, J AU - Xia, Q AU - Warner, W G AU - Boudreau, MD AU - Warbritton, A AU - Howard, P C AU - Fu, P P AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA, peterfu@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 581 EP - 589 VL - 23 IS - 10 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Skin KW - Cosmetics KW - Homeostasis KW - Esters KW - Light effects KW - Topical application KW - U.V. radiation KW - Palmitic acid KW - Vitamin A KW - Cream KW - Sunlight KW - Retinoids KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20891036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Levels+of+retinyl+palmitate+and+retinol+in+the+skin+of+SKH-1+mice+topically+treated+with+retinyl+palmitate+and+concomitant+exposure+to+simulated+solar+light+for+thirteen+weeks&rft.au=Yan%2C+J%3BXia%2C+Q%3BWarner%2C+W+G%3BBoudreau%2C+MD%3BWarbritton%2C+A%3BHoward%2C+P+C%3BFu%2C+P+P&rft.aulast=Yan&rft.aufirst=J&rft.date=2007-11-01&rft.volume=23&rft.issue=10&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090904 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - U.V. radiation; Skin; Vitamin A; Palmitic acid; Cream; Sunlight; Cosmetics; Homeostasis; Retinoids; Esters; Topical application; Light effects DO - http://dx.doi.org/10.1177/0748233708090904 ER - TY - JOUR T1 - UVA photoirradiation of anhydroretinol - formation of singlet oxygen and superoxide AN - 20889850; 8398082 AB - Anhydroretinol is a metabolite of vitamin A (retinol) and a major photodecomposition product of retinyl palmitate and retinyl acetate. Anhydroretinol is biologically active, inducing cell death in lymphoblastoid cells, prevention of N-methyl-N-nitrosourea-induced mammary cancer, and inhibition of cell growth in lymphocytes. We have previously determined that photoirradiation of anhydroretinol in the presence of a lipid, methyl linoleate, with UVA light-induced lipid peroxidation. In the present study, electron spin resonance (ESR) spin-trap techniques were employed to explore the mechanism of lipid peroxidation initiation. Irradiation of anhydroretinol by UVA in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. During photoirradiation in the presence of 5,5-dimethyl N-oxide pyrroline (DMPO), a specific probe for superoxide, ESR signals for DMPO-OOH were formed, and these signals were quenched by superoxide dismutase. The involvement of singlet oxygen on the induction of lipid peroxidation was also evidenced by the observation that lipid peroxidation was inhibited by sodium azide and enhanced by deuterium oxide. Our overall results provide evidence that photoirradiation of anhydroretinol with UVA light generates reactive oxygen species, e.g. singlet oxygen and superoxide, which mediate the induction of lipid peroxidation. JF - Toxicology and Industrial Health AU - Yin, J J AU - Xia, Q AU - Fu, P P AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA, junjie.yin@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 625 EP - 631 VL - 23 IS - 10 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Sodium azide KW - N-Oxides KW - Probes KW - Metabolites KW - Lymphocytes KW - Acetic acid KW - Cancer KW - Lipid peroxidation KW - Light effects KW - Cell death KW - U.V. radiation KW - Reactive oxygen species KW - Radiation KW - Superoxide dismutase KW - Palmitic acid KW - Vitamin A KW - oxides KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20889850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=UVA+photoirradiation+of+anhydroretinol+-+formation+of+singlet+oxygen+and+superoxide&rft.au=Yin%2C+J+J%3BXia%2C+Q%3BFu%2C+P+P&rft.aulast=Yin&rft.aufirst=J&rft.date=2007-11-01&rft.volume=23&rft.issue=10&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090909 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sodium azide; Probes; N-Oxides; Metabolites; Lymphocytes; Acetic acid; Lipid peroxidation; Cancer; Light effects; Cell death; U.V. radiation; Radiation; Reactive oxygen species; Superoxide dismutase; Vitamin A; Palmitic acid; oxides DO - http://dx.doi.org/10.1177/0748233708090909 ER - TY - JOUR T1 - The NIOSH Total Inward Leakage Project AN - 20883452; 8416021 AB - The National Institute for Occupational Safety and Health (NIOSH) conducts a range of efforts in the areas of research, information, and service. The NIOSH program portfolio focuses on relevance, quality, and impact. This is achieved through strong involvement of partners and stakeholders through the entire research continuum (conceiving, planning, conducting, translating, disseminating, and evaluating). The programmatic and support structures provide a foundation for staff to carry out its mission to provide national and world leadership to prevent work-related illnesses and injuries. JF - Occupational Health & Safety AU - Ann, R B AD - National Institute for Occupational Safety and Health's National Personal Protective Technology Laboratory, West Virginia University, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 34 EP - 38 VL - 76 IS - 11 SN - 0362-4064, 0362-4064 KW - Health & Safety Science Abstracts KW - Leakage KW - Injuries KW - Occupational safety KW - foundations KW - portfolios KW - stakeholders KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20883452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Health+%26+Safety&rft.atitle=The+NIOSH+Total+Inward+Leakage+Project&rft.au=Ann%2C+R+B&rft.aulast=Ann&rft.aufirst=R&rft.date=2007-11-01&rft.volume=76&rft.issue=11&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Occupational+Health+%26+Safety&rft.issn=03624064&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - stakeholders; Leakage; Occupational safety; Injuries; foundations; portfolios ER - TY - JOUR T1 - Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease AN - 20704872; 7630838 AB - Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359 /95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1 beta , IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines. JF - Microbial Pathogenesis AU - Braun, LE AU - Sutter, DE AU - Eichelberger, M C AU - Pletneva, L AU - Kokai-Kun, J F AU - Blanco, JCG AU - Prince, G A AU - Ottolini, M G AD - Inc., Rockville, MD 20850, USA, Maryna.Eichelberger@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 208 EP - 216 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 43 IS - 5-6 SN - 0882-4010, 0882-4010 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Interleukin 6 KW - Hypothermia KW - Mortality KW - Influenza A KW - Interleukin 1 KW - Animal models KW - Sigmodon hispidus KW - Bacteremia KW - Pathogens KW - Superinfection KW - Interleukin 10 KW - mRNA KW - Inflammation KW - pandemics KW - Lung KW - Influenza A virus KW - Cytokines KW - Staphylococcus aureus KW - J 02410:Animal Diseases KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20704872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Co-infection+of+the+cotton+rat+%28Sigmodon+hispidus%29+with+Staphylococcus+aureus+and+influenza+A+virus+results+in+synergistic+disease&rft.au=Braun%2C+LE%3BSutter%2C+DE%3BEichelberger%2C+M+C%3BPletneva%2C+L%3BKokai-Kun%2C+J+F%3BBlanco%2C+JCG%3BPrince%2C+G+A%3BOttolini%2C+M+G&rft.aulast=Braun&rft.aufirst=LE&rft.date=2007-11-01&rft.volume=43&rft.issue=5-6&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2007.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Temperature effects; Mortality; Hypothermia; Influenza A; Interleukin 1; Animal models; Bacteremia; Pathogens; Superinfection; Interleukin 10; Inflammation; mRNA; pandemics; Lung; Cytokines; Influenza A virus; Sigmodon hispidus; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.micpath.2007.03.005 ER - TY - JOUR T1 - Comparison of Direct Genome Restriction Enzyme Analysis and Pulsed-Field Gel Electrophoresis for Typing of Vibrio vulnificus and Their Correspondence with Multilocus Sequence Typing Data AN - 20551099; 7928240 AB - We compared the potential of direct genome restriction enzyme analysis (DGREA) and pulsed-field gel electrophoresis (PFGE) for discriminating Vibrio vulnificus isolates from clinical (23) and environmental (17) sources. The genotypes generated by both methodologies were compared to previous multilocus sequence typing (MLST) data. DGREA established clearer relationships among V. vulnificus strains and was more consistent with MLST than with PFGE. DGREA is a very promising tool for epidemiological and ecological studies of V. vulnificus. JF - Applied and Environmental Microbiology AU - Gonzalez-Escalona, Narjol AU - Whitney, Brooke AU - Jaykus, Lee-Ann AU - DePaola, Angelo AD - Department of Food Science, North Carolina State University, Raleigh, North Carolina. FDA Gulf Coast Seafood Laboratory, Dauphin Island, Alabama Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 7494 EP - 7500 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 22 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Vibrio vulnificus KW - Pulsed-field gel electrophoresis KW - Enzymes KW - Genotypes KW - multilocus sequence typing KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Comparison+of+Direct+Genome+Restriction+Enzyme+Analysis+and+Pulsed-Field+Gel+Electrophoresis+for+Typing+of+Vibrio+vulnificus+and+Their+Correspondence+with+Multilocus+Sequence+Typing+Data&rft.au=Gonzalez-Escalona%2C+Narjol%3BWhitney%2C+Brooke%3BJaykus%2C+Lee-Ann%3BDePaola%2C+Angelo&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2007-11-01&rft.volume=73&rft.issue=22&rft.spage=7494&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Pulsed-field gel electrophoresis; Enzymes; Genotypes; multilocus sequence typing; Vibrio vulnificus ER - TY - JOUR T1 - A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis AN - 20527752; 7745882 AB - Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection. JF - Postgraduate Medical Journal AU - Steingart, Karen R AU - Henry, Megan AU - Laal, Suman AU - Hopewell, Philip C AU - Ramsay, Andrew AU - Menzies, Dick AU - Cunningham, Jane AU - Weldingh, Karin AU - Pai, Madhukar AD - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA County of Sacramento Department of Health and Human Services, Sacramento, California, USA Veterans Affairs Medical Center and Departments of Pathology and Microbiology, New York University School of Medicine, New York, USA UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen S, Denmark Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 705 EP - 712 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 83 IS - 985 SN - 0032-5473, 0032-5473 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Human immunodeficiency virus KW - Immunoglobulin G KW - Tuberculosis KW - Infection KW - Children KW - Lymph nodes KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20527752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+Medical+Journal&rft.atitle=A+systematic+review+of+commercial+serological+antibody+detection+tests+for+the+diagnosis+of+extrapulmonary+tuberculosis&rft.au=Steingart%2C+Karen+R%3BHenry%2C+Megan%3BLaal%2C+Suman%3BHopewell%2C+Philip+C%3BRamsay%2C+Andrew%3BMenzies%2C+Dick%3BCunningham%2C+Jane%3BWeldingh%2C+Karin%3BPai%2C+Madhukar&rft.aulast=Steingart&rft.aufirst=Karen&rft.date=2007-11-01&rft.volume=83&rft.issue=985&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Postgraduate+Medical+Journal&rft.issn=00325473&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoglobulin G; Tuberculosis; Children; Infection; Lymph nodes; Human immunodeficiency virus ER - TY - JOUR T1 - Effects on Outpatient and Emergency Mental Health Care of Strict Medicaid Early Periodic Screening, Diagnosis, and Treatment Enforcement AN - 20521864; 7928520 AB - We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed-effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (out-patient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims. JF - American Journal of Public Health AU - Snowden, Lonnie R AU - Masland, Mary C AU - Wallace, Neal T AU - Evans-Cuellar, Allison AD - Lonnie R. Snowden is with the School of Social Welfare and the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Mary C. Masland is with the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Neal T. Wallace is with the Division of Public Administration, Mark O. Hatfield School of Government, Portland State University, Portland, Ore. Allison Evans-Cuellar is with the Department of Health Policy and Management, Joseph P. Mailman School of Public Health, Columbia University, New York, NY Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1951 EP - 1956 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 11 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Effects+on+Outpatient+and+Emergency+Mental+Health+Care+of+Strict+Medicaid+Early+Periodic+Screening%2C+Diagnosis%2C+and+Treatment+Enforcement&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BWallace%2C+Neal+T%3BEvans-Cuellar%2C+Allison&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2007-11-01&rft.volume=97&rft.issue=11&rft.spage=1951&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Improved BLAST searches using longer words for protein seeding AN - 20498081; 7929366 AB - MOTIVATION: The blastp and tblastn modules of BLAST are widely used methods for searching protein queries against protein and nucleotide databases, respectively. One heuristic used in BLAST is to consider only database sequences that contain a high-scoring match of length at most 5 to the query. We implemented the capability to use words of length 6 or 7. We demonstrate an improved trade-off between running time and retrieval accuracy, controlled by the score threshold used for short word matches. For example, the running time can be reduced by 20-30% while achieving ROC (receiver operator characteristic) scores similar to those obtained with current default parameters. AVAILABILITY: The option to use long words is in the NCBI C and C++ toolkit code for BLAST, starting with version 2.2.16 of blastall. A Linux executable used to produce the results herein is available at: ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/protein_longwords. JF - Bioinformatics AU - Shiryev, Sergey A AU - Papadopoulos, Jason S AU - Schaeffer, Alejandro A AU - Agarwala, Richa AD - Department of Health and Human Services, National Center for Biotechnology Information, National Institutes of Health, richa@helix.nih.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 2949 EP - 2951 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples[at]oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 21 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Seeding KW - Problem solving KW - Bioinformatics KW - Nucleotides KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20498081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Improved+BLAST+searches+using+longer+words+for+protein+seeding&rft.au=Shiryev%2C+Sergey+A%3BPapadopoulos%2C+Jason+S%3BSchaeffer%2C+Alejandro+A%3BAgarwala%2C+Richa&rft.aulast=Shiryev&rft.aufirst=Sergey&rft.date=2007-11-01&rft.volume=23&rft.issue=21&rft.spage=2949&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Problem solving; Seeding; Bioinformatics; Nucleotides ER - TY - JOUR T1 - Oral treatment with ACCUTANE super(()R) does not increase measures of anhedonia or depression in rats AN - 20491796; 7938371 AB - Reports of depression and/or suicide with ACCUTANE super(()R) (13-cis-retinoic acid (13-cis-RA)) use prompted studies in a rodent model to ascertain its potential effects. Previously, there were no effects on measures of anhedonia (intake of a saccharin-flavored solution) and depression (forced swim test (FST) behaviors) in rats treated with 7.5 or 22.5 mg/kg 13-cis-RA [S.A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459.]. Here, dose and temporal thresholds were investigated by increasing the maximum 13-cis-RA dose to 30 mg/kg, extending treatment duration, and measuring behaviors repeatedly. Beginning on post-natal day 59, male and female Sprague-Dawley rats were gavaged with soybean oil, 7.5 or 30 mg/kg/day of 13-cis-RA for approximately 19 weeks. FST behaviors were measured after 24, 82, and 131 treatment days and saccharin intake (0.03% solution) was measured at baseline and after 14, 35, 56, and 112 treatment days. Body weight and food intake were not altered by treatment. FST durations of swim, climb/struggle, and immobility were unaffected by 13-cis-RA at any time during treatment. More males than females required ''rescue'' in the FST but there was no treatment effect on number of rats requiring early removal. 13-cis-RA treatment had no effects on saccharin intake at any time. Given that the 7.5 mg/kg dose produces serum levels which parallel those of humans [S.A. Ferguson, P.H. Siitonen, F.J. Cisneros, B. Gough, J.F. Young, Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats, Basic Clin. Pharmacol. Toxicol 98 (2006) 582-587.], these results are quite relevant. Combined with previous results, these results provide further evidence that 13-cis-RA does not produce behavioral alterations indicative of depression in rats. JF - Neurotoxicology and Teratology AU - Ferguson, SA AU - Cisneros, F J AU - Hanig, J P AU - Berry, K J AD - National Center for Toxicological Research/FDA, Jefferson, AR 72079 United States, Sherry.Ferguson@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 642 EP - 651 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 29 IS - 6 SN - 0892-0362, 0892-0362 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Fruits KW - Saccharin KW - Depression KW - Retinoic acid KW - Animal models KW - Suicide KW - Sex differences KW - Pharmacokinetics KW - Soybeans KW - Serum levels KW - Oil KW - Body weight KW - Food intake KW - Hedonic response KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20491796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Oral+treatment+with+ACCUTANE+super%28%28%29R%29+does+not+increase+measures+of+anhedonia+or+depression+in+rats&rft.au=Ferguson%2C+SA%3BCisneros%2C+F+J%3BHanig%2C+J+P%3BBerry%2C+K+J&rft.aulast=Ferguson&rft.aufirst=SA&rft.date=2007-11-01&rft.volume=29&rft.issue=6&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2007.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fruits; Saccharin; Depression; Retinoic acid; Animal models; Suicide; Sex differences; Pharmacokinetics; Soybeans; Oil; Serum levels; Body weight; Food intake; Hedonic response DO - http://dx.doi.org/10.1016/j.ntt.2007.09.003 ER - TY - JOUR T1 - Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years AN - 20410406; 7637489 AB - A total of 232 alkaloids, representing 21 structural classes were detected in skin extracts from the dendrobatid poison frog Oophaga pumilio, collected from 53 different populations from over 30 years of research. The highly toxic pumiliotoxins and allopumiliotoxins, along with 5,8-disubstitiuted and 5,6,8-trisubstituted indolizidines, all of which are proposed to be of dietary mite origin, were common constituents in most extracts. One decahydroquinoline (DHQ), previously shown be of ant origin, occurred in many extracts often as a major alkaloid, while other DHQs occurred rather infrequently. Histrionicotoxins, thought to be of ant origin, did not appear to possess a specific pattern of occurrence among the populations, but when present, were usually found as major components. Certain 3,5-disubstituted pyrrolizidines and indolizidines, known to be of ant origin, did occur in extracts, but infrequently. Alkaloid composition differed with regard to geographic location of frog populations, and for populations that were sampled two or more times during the 30-year period significant changes in alkaloid profiles sometimes occurred. The results of this study indicate that chemical defense in a dendrobatid poison frog is dependent on geographic location and habitat type, which presumably controls the abundance and nature of alkaloid-containing arthropods. JF - Toxicon AU - Saporito, R A AU - Donnelly, MA AU - Jain, P AU - Martin Garraffo, H AU - Spande, T F AU - Daly, J W AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA, jdaly@nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 757 EP - 778 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 50 IS - 6 SN - 0041-0101, 0041-0101 KW - Ants KW - ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Panama KW - Geographical distribution KW - Skin KW - Amphibiotic species KW - Biochemistry KW - Biological poisons KW - Costa Rica KW - Abundance KW - Anura KW - Formicidae KW - Animal physiology KW - Freshwater KW - Habitat KW - Alkaloids KW - Arthropoda KW - Oophaga pumilio KW - X 24370:Natural Toxins KW - Q1 08326:Physiology, biochemistry, biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20410406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Spatial+and+temporal+patterns+of+alkaloid+variation+in+the+poison+frog+Oophaga+pumilio+in+Costa+Rica+and+Panama+over+30+years&rft.au=Saporito%2C+R+A%3BDonnelly%2C+MA%3BJain%2C+P%3BMartin+Garraffo%2C+H%3BSpande%2C+T+F%3BDaly%2C+J+W&rft.aulast=Saporito&rft.aufirst=R&rft.date=2007-11-01&rft.volume=50&rft.issue=6&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2007.06.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Alkaloids; Biochemistry; Amphibiotic species; Biological poisons; Animal physiology; Skin; Abundance; Habitat; Arthropoda; Oophaga pumilio; Formicidae; Anura; Panama; Costa Rica; Freshwater DO - http://dx.doi.org/10.1016/j.toxicon.2007.06.022 ER - TY - JOUR T1 - Diffuse-interface theory for structure formation and release behavior in controlled drug release systems AN - 20339270; 7637284 AB - A common method of controlling drug release has been to incorporate the drug into a polymer matrix, thereby creating a diffusion barrier that slows the rate of drug release. It has been demonstrated that the internal microstructure of these drug-polymer composites can significantly impact the drug release rate. However, the effect of processing conditions during manufacture on the composite structure and the subsequent effects on release behavior are not well understood. We have developed a diffuse-interface theory for microstructure evolution that is based on interactions between drug, polymer and solvent species, all of which may be present in either crystalline or amorphous states. Because the theory can be applied to almost any specific combination of material species and over a wide range of environmental conditions, it can be used to elucidate and quantify the relationships between processing, microstructure and release response in controlled drug release systems. Calculations based on the theory have now demonstrated that, for a characteristic delivery system, variations in microstructure arising due to changes in either drug loading or processing time, i.e. evaporation rate, could have a significant impact on both the bulk release kinetics and the uniformity of release across the system. In fact, we observed that changes in process time alone can induce differences in bulk release of almost a factor of two and typical non-uniformities of +/-30% during the initial periods of release. Because these substantial variations may have deleterious clinical ramifications, it is critical that both the system microstructure and the control of that microstructure are considered to ensure the device will be both safe and effective in clinical use. JF - Acta Biomaterialia AU - Saylor, D M AU - Kim, C S AU - Patwardhan, D V AU - Warren, JA AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD 20903, USA, david.saylor@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 851 EP - 864 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 3 IS - 6 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Evaporation KW - Kinetics KW - Solvents KW - Diffusion KW - Environmental conditions KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20339270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Diffuse-interface+theory+for+structure+formation+and+release+behavior+in+controlled+drug+release+systems&rft.au=Saylor%2C+D+M%3BKim%2C+C+S%3BPatwardhan%2C+D+V%3BWarren%2C+JA&rft.aulast=Saylor&rft.aufirst=D&rft.date=2007-11-01&rft.volume=3&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2007.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drug delivery; Environmental conditions; Kinetics; Evaporation; Solvents; Diffusion DO - http://dx.doi.org/10.1016/j.actbio.2007.03.011 ER - TY - JOUR T1 - Bacterial endospore inactivation caused by outgassing of vapourous hydrogen peroxide from polymethyl methacrylate (Plexiglas super( registered )) AN - 19863317; 7997339 AB - Aims: To investigate the cause and to eliminate the inactivation of Bacillus anthracis strain Sterne spores settled onto agar and stainless steel surfaces in plastic holders. Methods and Results: In an experimental chamber in which spores settled onto sampling surfaces, vapourous hydrogen peroxide (VHP) was used for decontamination between experiments. It was demonstrated that hydrogen peroxide (H sub(2)O sub(2)) absorbed into plastic (Plexiglas super( registered )) surfaces and could outgas in the sample holders. Further experiments demonstrated that H sub(2)O sub(2) was released from Plexiglas super( registered ) sample holders in sufficient quantity to inactivate spores. High temperature degassing (30-35 degree C) for several days or aluminum coating of the surfaces were two remedies found to be effective in preventing inadvertent spore inactivation. Conclusions: H sub(2)O sub(2) can be absorbed into plastic and released after an extended period of time (weeks), allowing a sufficient concentration to accumulate in small volumes to inactivate spores. Outgassing the plastic or coating the surface with an impermeable layer are potential solutions to reduce spore inactivation. Significance and Impact of the Study: Many studies with bacilli and other organisms are carried out using small plastic containers that may have been sterilized using H sub(2)O sub(2) or other agents. This study presents a cautionary note to ensure elimination of H sub(2)O sub(2) or other sterilizing agents to prevent spurious results. JF - Letters in Applied Microbiology AU - Baron, P A AU - Estill, C F AU - Beard, J K AU - Hein, MJ AU - Larsen, L AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA, pbaron@cdc.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 485 EP - 490 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 45 IS - 5 SN - 0266-8254, 0266-8254 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacillus anthracis KW - decontamination KW - hydrogen peroxide KW - outgassing KW - Plexiglas KW - spore KW - sterilization KW - VHP KW - Temperature effects KW - Agar KW - Bacilli KW - Decontamination KW - Hydrogen peroxide KW - Aluminum KW - Plastics KW - Sampling KW - Spores KW - polymethylmethacrylate KW - Coatings KW - stainless steel KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19863317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Bacterial+endospore+inactivation+caused+by+outgassing+of+vapourous+hydrogen+peroxide+from+polymethyl+methacrylate+%28Plexiglas+super%28+registered+%29%29&rft.au=Baron%2C+P+A%3BEstill%2C+C+F%3BBeard%2C+J+K%3BHein%2C+MJ%3BLarsen%2C+L&rft.aulast=Baron&rft.aufirst=P&rft.date=2007-11-01&rft.volume=45&rft.issue=5&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=02668254&rft_id=info:doi/10.1111%2Fj.1472-765X.2007.02209.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Bacilli; Agar; Hydrogen peroxide; Aluminum; Decontamination; Sampling; Plastics; polymethylmethacrylate; Spores; stainless steel; Coatings; Bacillus anthracis DO - http://dx.doi.org/10.1111/j.1472-765X.2007.02209.x ER - TY - JOUR T1 - Annexin A2 is a soluble mediator of macrophage activation AN - 19810224; 8124708 AB - On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had generally been thought to play an anti-inflammatory role, soluble A2t stimulates MAP kinase activity in bone marrow stromal cells downstream of a recently cloned receptor. This raises the question of whether A2t activates human macrophages via MAP kinases and whether it might be capable of acting as an inflammatory mediator. To this end, human monocyte-derived macrophages were treated with soluble A2t and MAP kinase phosphorylation, p65 NF- Kappa B activation, and inflammatory mRNA and protein levels were measured. It was found that A2t caused rapid phosphorylation of several MAP kinases, as well as translocation of p65 NF- Kappa B to the nucleus. A2t stimulated the production of TNF- alpha , IL-1 beta , and IL-6, as well as several members of the chemokine family within 24 h, which are capable of recruitment and/or activation of a broad range of leukocyte classes. Furthermore, A2t-activated macrophages demonstrated enhanced phagocytic ability for the ingestion of GFP-expressing Escherichia coli. These data are the first to suggest the participation of an annexin in microbial clearance, as well as the establishment of inflammation and the immune response, including the recruitment and activation of immune cells to the site of infection. JF - Journal of Leukocyte Biology AU - Swisher, JFA AU - Khatri, U AU - Feldman, G M AD - Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bldg. 29A, Rm. 3C22, 29 Lincoln Dr., HFD-123, Bethesda, MD 20892, USA, gerald.feldman@fda.hhs.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1174 EP - 1184 VL - 82 IS - 5 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Macrophages KW - Interleukin 6 KW - Chemokines KW - stromal cells KW - Interleukin 1 KW - Bone marrow KW - Infection KW - NF- Kappa B protein KW - Cell activation KW - Nuclear transport KW - Phosphorylation KW - Phagocytes KW - Escherichia coli KW - Monocytes KW - MAP kinase KW - Data processing KW - Leukocytes KW - Pathogens KW - Inflammation KW - mRNA KW - Plasma levels KW - Annexins KW - Tumor necrosis factor- alpha KW - Immune response KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19810224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Annexin+A2+is+a+soluble+mediator+of+macrophage+activation&rft.au=Swisher%2C+JFA%3BKhatri%2C+U%3BFeldman%2C+G+M&rft.aulast=Swisher&rft.aufirst=JFA&rft.date=2007-11-01&rft.volume=82&rft.issue=5&rft.spage=1174&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0307154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Macrophages; Chemokines; MAP kinase; Data processing; stromal cells; Interleukin 1; Leukocytes; Bone marrow; Pathogens; Infection; mRNA; Cell activation; Inflammation; NF- Kappa B protein; Nuclear transport; Plasma levels; Annexins; Phosphorylation; Phagocytes; Monocytes; Immune response; Tumor necrosis factor- alpha; Escherichia coli DO - http://dx.doi.org/10.1189/jlb.0307154 ER - TY - JOUR T1 - Comparison of Neisseria meningitidis serogroup W135 polysaccharide- tetanus toxoid conjugate vaccines made by periodate activation of O- acetylated, non-O-acetylated and chemically de-O-acetylated polysaccharide AN - 19634852; 8767953 AB - Polysaccharide (PS) and tetanus toxoid (TT) protein conjugate vaccines were prepared using O-acetylated (OAc super(+)), O-acetyl negative (OAc super(-)) and chemically de-O-acetylated (de-OAc) meningococcal W135 PS. The PSs were activated by periodate oxidation and coupled to hydrazine derivatized TT. High performance anion exchange chromatography of acid hydrolysates of periodate activated W135 PSs, showed that galactose residues in OAc super(+) PS were more sensitive to the periodate oxidation step than they were in the OAc super(-) PS or de-OAc PS. Mouse antisera against OAc super(-)-TT conjugate vaccines recognized both OAc super(-) and OAc super(+) PS by ELISAs and had high bactericidal titers against both OAc super(+) and OAc super(-) W135 strains. Purified high molecular weight (HMW) conjugates showed higher PS to protein ratios in OAc super(-)-TT sub((HMW)) and de-OAc-TT sub((HMW)) indicating better conjugation efficiency than OAc super(+)-TT sub((HMW)) conjugate. Antisera against the HMW fractions gave higher bactericidal titers than antisera against unfractionated conjugates. Inhibition ELISAs indicated that OAc super(-) and OAc super(+) HMW conjugates induced antibodies that bound both OAc super(+) and OAc super(-) PS. Thus, for W135, PS O-acetylation does not contribute a dominant immunogenic epitope. The OAc super(-) PS may be a good starting material for preparing W135 PS-TT conjugate vaccines using periodate oxidation. JF - Vaccine AU - Gudlavalleti, Seshu K AU - Lee, Che-Hung AU - Norris, Scott E AU - Paul-Satyaseela, Maneesh AU - Vann, Willie F AU - Frasch, Carl E AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, MD, USA, gudlavalletis@yahoo.com Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 7972 EP - 7980 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 46 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Neisseria meningitidis serogroup W135 KW - Polysaccharide O-acetylation KW - Conjugate vaccines KW - Galactose KW - Enzyme-linked immunosorbent assay KW - Anions KW - Hydrazine KW - Chromatography KW - Neisseria meningitidis KW - Polysaccharides KW - Tetanus KW - Antibodies KW - Antisera KW - Immunogenicity KW - Oxidation KW - Vaccines KW - Epitopes KW - Hydrolysates KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19634852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Comparison+of+Neisseria+meningitidis+serogroup+W135+polysaccharide-+tetanus+toxoid+conjugate+vaccines+made+by+periodate+activation+of+O-+acetylated%2C+non-O-acetylated+and+chemically+de-O-acetylated+polysaccharide&rft.au=Gudlavalleti%2C+Seshu+K%3BLee%2C+Che-Hung%3BNorris%2C+Scott+E%3BPaul-Satyaseela%2C+Maneesh%3BVann%2C+Willie+F%3BFrasch%2C+Carl+E&rft.aulast=Gudlavalleti&rft.aufirst=Seshu&rft.date=2007-11-01&rft.volume=25&rft.issue=46&rft.spage=7972&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Galactose; Enzyme-linked immunosorbent assay; Anions; Hydrazine; Chromatography; Tetanus; Polysaccharides; Antisera; Antibodies; Immunogenicity; Oxidation; Vaccines; Hydrolysates; Epitopes; Neisseria meningitidis DO - http://dx.doi.org/10.1016/j.vaccine.2007.06.018 ER - TY - JOUR T1 - New procedure for assessing sequential manual lifting jobs using the revised NIOSH lifting equation AN - 19549034; 8681501 AB - A sequential manual lifting job is defined as a job where workers rotate between a series of manual lifting rotation slots or elements at specified time intervals during the course of a work shift. The original NIOSH lifting equation lacked a method for assessing the physical demands of these types of jobs. This paper presents the sequential lifting index (SLI), a new conceptual method for assessing the physical demands for sequential manual lifting jobs. The new method is similar to the composite lifting index (CLI) method that was provided by NIOSH for assessing multi-task jobs. The SLI method expands upon the methods originally provided by NIOSH by providing a simple method for estimating the relative magnitude of physical stress for sequential manual lifting jobs. It should also be useful in assisting safety and health specialists to prioritize or rank hazardous jobs within a plant. JF - Ergonomics AU - Waters, T R AU - Lu, M-L AU - Occhipinti, E AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1761 EP - 1770 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 50 IS - 11 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - shift work KW - composite materials KW - Stress KW - working conditions KW - lifting KW - Ergonomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19549034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=New+procedure+for+assessing+sequential+manual+lifting+jobs+using+the+revised+NIOSH+lifting+equation&rft.au=Waters%2C+T+R%3BLu%2C+M-L%3BOcchipinti%2C+E&rft.aulast=Waters&rft.aufirst=T&rft.date=2007-11-01&rft.volume=50&rft.issue=11&rft.spage=1761&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130701674364 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - lifting; Ergonomics; Stress; working conditions; composite materials; shift work DO - http://dx.doi.org/10.1080/00140130701674364 ER - TY - JOUR T1 - Race, Occupation, and Lung Cancer: Detecting Disparities With Death Certificate Data AN - 19522672; 7768320 AB - Objectives: To determine whether the analysis of death certificate data would reveal the same relationship among race, occupational exposure, and lung cancer mortality observed by a large cohort study. Methods: An occupation-specific mortality odds ratio (MOR) for lung cancer (ICD-162) versus all other causes was calculated for 218, 341 black men and white men who had been employed in the metal industries. Results: Black men were at increased risk for lung cancer mortality when compared with white men among the 4668 oven workers (MOR = 1.38, 95% CI = 1.10 to 1.73), but not among the 33, 605 white-collar workers (MOR = 0.95, 95% CI = 0.74 to 1.23). Conclusions: Our findings corroborate a previously demonstrated association among exposure to carcinogenic coke oven emissions, race, and lung cancer mortality, and support the use of death certificate data to help identify occupations with racial disparities in lung cancer mortality. JF - Journal of Occupational and Environmental Medicine AU - Birdsey, J AU - Alterman, T AU - Petersen, M R AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R17, Cincinnati, OH 45226, USA, JBirdsey@cdc.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1257 EP - 1263 VL - 49 IS - 11 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Mortality KW - Carcinogenicity KW - Emissions KW - Coke KW - Metal industry KW - Ethnic groups KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Race%2C+Occupation%2C+and+Lung+Cancer%3A+Detecting+Disparities+With+Death+Certificate+Data&rft.au=Birdsey%2C+J%3BAlterman%2C+T%3BPetersen%2C+M+R&rft.aulast=Birdsey&rft.aufirst=J&rft.date=2007-11-01&rft.volume=49&rft.issue=11&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318154c094 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Carcinogenicity; Emissions; Coke; Metal industry; Occupational exposure; Ethnic groups; Lung cancer DO - http://dx.doi.org/10.1097/JOM.0b013e318154c094 ER - TY - JOUR T1 - Genetic Diversity among Clonal Lineages within Escherichia coli O157:H7 Stepwise Evolutionary Model AN - 19464930; 8044006 AB - Escherichia coli O157:H7 variants were examined for trait mutations and by molecular subtyping to better define clonal complexes postulated on the O157:H7 evolution model. Strains of beta -glucuronidase-positive, sorbitol-negative O157:H7 isolated in United States and Japan were identical to A5 clonal strain and shared sequence type (ST)-65 by multilocus sequence typing (MLST); thus, they belong in A5. However, these strains exhibited pulsed-field gel electrophoresis (PFGE) profile differences that suggested genomic divergence between populations. Sorbitol-fermenting O157 (SFO157) strains from Finland, Scotland, and Germany were identical to A4 clonal strain and belong in A4. Some SFO157 strains, isolated years apart and from different countries, had identical PFGE profiles, suggesting a common origin. Despite similarities, some Finnish and Scottish and all of the German strains have ST-75 ("German clone"), whereas others have ST-76, a new variant ("Scottish clone"). MLST of strains in other clonal complexes also discriminated strains thought to be identical and showed that genetic differences will further distinguish clonal populations into subclones. JF - Emerging Infectious Diseases AU - Feng, PCH AU - Monday AU - Lacher, D W AU - Allison, L AU - Siitonen, A AU - Keys, C AU - Eklund, M AU - Nagano, H AU - Karch, H AU - Keen, J AU - Whittam, T S AD - Food and Drug Administration, College Park, Maryland, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 VL - 13 IS - 11 SN - 1080-6040, 1080-6040 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Escherichia coli KW - Pulsed-field gel electrophoresis KW - Genetic diversity KW - genomics KW - Mutation KW - Evolution KW - multilocus sequence typing KW - Models KW - J 02310:Genetics & Taxonomy KW - W 30900:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Genetic+Diversity+among+Clonal+Lineages+within+Escherichia+coli+O157%3AH7+Stepwise+Evolutionary+Model&rft.au=Feng%2C+PCH%3BMonday%3BLacher%2C+D+W%3BAllison%2C+L%3BSiitonen%2C+A%3BKeys%2C+C%3BEklund%2C+M%3BNagano%2C+H%3BKarch%2C+H%3BKeen%2C+J%3BWhittam%2C+T+S&rft.aulast=Feng&rft.aufirst=PCH&rft.date=2007-11-01&rft.volume=13&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Pulsed-field gel electrophoresis; Genetic diversity; genomics; Mutation; Evolution; Models; multilocus sequence typing; Escherichia coli ER - TY - JOUR T1 - A New Zealand outbreak of norovirus gastroenteritis linked to the consumption of imported raw Korean oysters. AN - 68455409; 17972982 AB - To investigate an outbreak of gastroenteritis that occurred following an international rugby test at Eden Park (Auckland, New Zealand) on 17 June 2006. 387 patrons were interviewed. Cases were defined as those from one of four hospitality areas who consumed food or beverage at Eden Park on the evening of 17 June 2006 and subsequently suffered from diarrhoea or vomiting; or, stomach cramps and nausea. A case-control study was conducted and food and beverage items associated with illness were identified. Clinical specimens were requested from patrons and food handlers, and leftover foods were analysed for pathogens. A food safety assessment was conducted at the implicated catering premises. A total of 115 cases were identified. Attack rates varied between the four hospitality areas from 8% to 47%. Predominant symptoms among cases included nausea, vomiting, diarrhoea, stomach cramps, fever, and chills. The consumption of several foods was associated with an increased risk of illness but the strongest was for raw oysters consumed in Hospitality Area 1 (Risk Ratio 11.9; 95%CI 3.9-36.1; p<0.00001), attack rate 65%. Norovirus (genogroups I and II) was detected in samples provided by four of the cases and three unopened packets of implicated batches of imported Korean Pacific oysters (Crassostrea gigas) linked to the outbreak. This outbreak resulted from consumption of raw imported Korean oysters contaminated by norovirus. Labelling recommending cooking prior to consumption failed to prevent the outbreak. JF - The New Zealand medical journal AU - Simmons, Greg AU - Garbutt, Claire AU - Hewitt, Joanne AU - Greening, Gail AD - Population Protection Group, Auckland Regional Public Health Service, Auckland. gregs@adhb.govt.nz Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 SP - 1 VL - 120 IS - 1264 KW - Index Medicus KW - Animals KW - Humans KW - Feces -- virology KW - Case-Control Studies KW - Salmon -- virology KW - Korea KW - New Zealand -- epidemiology KW - Disease Reservoirs -- virology KW - Risk Assessment KW - Ostreidae -- virology KW - Gastroenteritis -- virology KW - Food Microbiology KW - Norovirus -- isolation & purification KW - Disease Outbreaks KW - Gastroenteritis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68455409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+Zealand+medical+journal&rft.atitle=A+New+Zealand+outbreak+of+norovirus+gastroenteritis+linked+to+the+consumption+of+imported+raw+Korean+oysters.&rft.au=Simmons%2C+Greg%3BGarbutt%2C+Claire%3BHewitt%2C+Joanne%3BGreening%2C+Gail&rft.aulast=Simmons&rft.aufirst=Greg&rft.date=2007-10-26&rft.volume=120&rft.issue=1264&rft.spage=U2773&rft.isbn=&rft.btitle=&rft.title=The+New+Zealand+medical+journal&rft.issn=1175-8716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Anti-TNFa Therapy Rescues Neonatal Mice from Lethal Arenavirus -Induced Meningoencephalitis. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715478; 4756348 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Pedras-Vasconcelos, Joao A AU - Puig, Montserrat AU - Sauder, Christian AU - Verthelyi, Daniela Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Mice KW - Meningoencephalitis KW - Neonates KW - Therapy KW - Arenavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Anti-TNFa+Therapy+Rescues+Neonatal+Mice+from+Lethal+Arenavirus+-Induced+Meningoencephalitis.&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BPuig%2C+Montserrat%3BSauder%2C+Christian%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Genotyping Using Next Generation Sequencing Technology. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40707112; 4752276 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Xiao, N AU - Desany, B AU - Bouffard, P AU - Burdett, L A AU - Welch, R AU - Yeager, M AU - Jarvie, T P AU - Harkins, T T AU - Qi, L. AU - Lu, J. AU - Chanock, S J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Technology KW - Genotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Human+Genotyping+Using+Next+Generation+Sequencing+Technology.&rft.au=Xiao%2C+N%3BDesany%2C+B%3BBouffard%2C+P%3BBurdett%2C+L+A%3BWelch%2C+R%3BYeager%2C+M%3BJarvie%2C+T+P%3BHarkins%2C+T+T%3BQi%2C+L.%3BLu%2C+J.%3BChanock%2C+S+J&rft.aulast=Xiao&rft.aufirst=N&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Common Variation at 8q24 and Prostate Cancer Risk. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40706416; 4752302 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Yeager-Jeffery, M AU - Welch, R AU - Hayes, R B AU - Bouffard, P AU - Xiao, N AU - Burdett, L AU - Orr, N AU - Crenshaw, A AU - Markovic, Z AU - Jacobs, K B AU - Jarvie, T P AU - Hunter, D AU - Hoover, R AU - Thomas, G AU - Harkins, T T AU - Chanock, S J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Common+Variation+at+8q24+and+Prostate+Cancer+Risk.&rft.au=Yeager-Jeffery%2C+M%3BWelch%2C+R%3BHayes%2C+R+B%3BBouffard%2C+P%3BXiao%2C+N%3BBurdett%2C+L%3BOrr%2C+N%3BCrenshaw%2C+A%3BMarkovic%2C+Z%3BJacobs%2C+K+B%3BJarvie%2C+T+P%3BHunter%2C+D%3BHoover%2C+R%3BThomas%2C+G%3BHarkins%2C+T+T%3BChanock%2C+S+J&rft.aulast=Yeager-Jeffery&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lived Mental Stress of Adolescents of Color in Foster Care. T2 - 6th World Congress on Stress AN - 39477248; 4675004 JF - 6th World Congress on Stress AU - Scott, Ella M Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Adolescents KW - Stress KW - Color KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39477248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Stress&rft.atitle=Lived+Mental+Stress+of+Adolescents+of+Color+in+Foster+Care.&rft.au=Scott%2C+Ella+M&rft.aulast=Scott&rft.aufirst=Ella&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Stress&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/stress2007/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Antisocial behavioral syndromes and DSM-IV drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 57234062; 200804150 AB - Background Antisocial behavioral syndromes, including antisocial personality disorder (ASPD), syndromal adult antisocial behavior (AABS) without conduct disorder (CD) before age 15, and CD without progression to ASPD ('CD only') are highly comorbid with drug use disorders (DUDs). Among patients in DUD treatment, antisocial syndromes are associated with greater severity and poorer outcomes. Comparative data concerning associations of antisocial syndromes with clinical characteristics of DUDs among general population adults have not previously been available. This study describes associations of antisocial syndromes with clinical characteristics of lifetime Diagnostic and Statistical Manual-Version IV DUDs in the general U.S. adult population. Methods This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (n=43,093, response rate=81%). Respondents (n=4068) with lifetime DUDs were classified according to whether they met criteria for ASPD, AABS, 'CD only,' or no antisocial syndrome. Associations of antisocial syndromes with clinical characteristics of DUDs were examined using logistic regression. Results Antisocial syndromes were significantly associated with the phenomenology of DUDs, particularly ASPD with the most severe clinical presentations. Associations with AABS were similar to those with ASPD; those with 'CD only' were weak, inconsistent, and not statistically significant. Patterns of associations differed little between men and women. Conclusions Both ASPD and AABS, but not 'CD only,' appear to identify greater clinical severity of DUDs among adults in the general U.S. population. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Goldstein, Rise B AU - Compton, Wilson M AU - Pulay, Attila J AU - Ruan, W June AU - Pickering, Roger P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 SP - 145 EP - 158 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 90 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Antisocial personality disorder KW - Conduct disorder KW - Drug use disorders KW - Conduct disorders KW - Antisocial behaviour KW - Drug abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57234062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Antisocial+behavioral+syndromes+and+DSM-IV+drug+use+disorders+in+the+United+States%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Goldstein%2C+Rise+B%3BCompton%2C+Wilson+M%3BPulay%2C+Attila+J%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-10-08&rft.volume=90&rft.issue=2-3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.02.023 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Antisocial behaviour; Conduct disorders; Drug abuse DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.02.023 ER - TY - CPAPER T1 - Differences in Adult and Neonatal BAFF/APRIL System: Implications for Polysaccharide Vaccines T2 - 2007 Keystone Symposia on Challenges of Global Vaccine Development (T1) AN - 39576600; 4721942 JF - 2007 Keystone Symposia on Challenges of Global Vaccine Development (T1) AU - Akkoyunlu, Mustafa Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 KW - Vaccines KW - BLyS protein KW - Neonates KW - Polysaccharides KW - APRIL protein KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Challenges+of+Global+Vaccine+Development+%28T1%29&rft.atitle=Differences+in+Adult+and+Neonatal+BAFF%2FAPRIL+System%3A+Implications+for+Polysaccharide+Vaccines&rft.au=Akkoyunlu%2C+Mustafa&rft.aulast=Akkoyunlu&rft.aufirst=Mustafa&rft.date=2007-10-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Challenges+of+Global+Vaccine+Development+%28T1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 5&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quantitative measurement of cyanide released from Prussian Blue. AN - 69057587; 17924254 AB - Prussian Blue (PB), ferric hexacyanoferrate is indicated for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide is 35-40% of PB's molecular composition, thus cyanide may be released during transit through the digestive tract under physiological pH. The U.S. Food and Drug Administration investigated the issue of cyanide release prior to drug approval to ensure the drug's benefits exceeded risks. To determine cyanide released from PB under pH conditions that bracket human physiological exposure. PB was incubated in situ at pH 1.0-12, 37 degrees C for 1-48 hours. Cyanide was measured using a validated colorimetric method by UV-VIS spectroscopy. PB had the highest cyanide release at pH 1 (135 ug/g) and lowest release at pH 5.0-7.0 from the highest daily dose of PB (17.5 g) (21 ug/g). Considering the minimal lethal dose of cyanide is approximately 50 mg, the maximal cyanide released (1.6 mg) does not present a safety concern. JF - Clinical toxicology (Philadelphia, Pa.) AU - Yang, Yongsheng AU - Brownell, Charles AU - Sadrieh, Nakissa AU - May, Joan AU - Del, Alfred AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research, Silver Spring, Maryland 20993, USA. PY - 2007 SP - 776 EP - 781 VL - 45 IS - 7 SN - 1556-3650, 1556-3650 KW - Antidotes KW - 0 KW - Cesium Radioisotopes KW - Ferrocyanides KW - Hydrogen Cyanide KW - 2WTB3V159F KW - ferric ferrocyanide KW - TLE294X33A KW - Abridged Index Medicus KW - Index Medicus KW - Cesium Radioisotopes -- poisoning KW - Hydrogen-Ion Concentration KW - Time Factors KW - Hydrogen Cyanide -- analysis KW - Hydrogen Cyanide -- chemistry KW - Ferrocyanides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69057587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.atitle=Quantitative+measurement+of+cyanide+released+from+Prussian+Blue.&rft.au=Yang%2C+Yongsheng%3BBrownell%2C+Charles%3BSadrieh%2C+Nakissa%3BMay%2C+Joan%3BDel%2C+Alfred&rft.aulast=Yang&rft.aufirst=Yongsheng&rft.date=2007-10-01&rft.volume=45&rft.issue=7&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.issn=15563650&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of an in vitro bioassay for the detection of purified ricin and castor bean in beverages and liquid food matrices. AN - 68443943; 17969621 AB - The potential use of ricin as a biological weapon in food highlights the necessity for the development of food-specific detection methods. Current methods for the detection of ricin consist of various immunoassays, which detect only one subunit of the ricin toxin and therefore may not be indicative of a biologically active molecule. An in vivo assay, such as a mouse bioassay, can indicate the biological activity of the toxin; however, this method is not feasible for laboratories that do not have animal testing facilities. The purpose of this study was to develop an in vitro assay for the detection of biologically active ricin in beverages and liquid foods. Acidic and high-protein beverages were spiked with either purified ricin or ground castor beans and added to cultured human Jurkat cells. After an overnight incubation, the supernatant was tested for lactate dehydrogenase (LDH) activity with a colorimetric assay. LDH was released from the cytosol upon cell damage and was positively correlated with cell death. Ricin was detectable in all the matrices tested, with a sensitivity of 10 to 100 pg/ml. Biologically active ricin was detectable in all the matrices incubated with ground castor bean material. This method provides a confirmatory way to detect biologically active ricin that can be utilized by laboratories lacking animal facilities. JF - Journal of food protection AU - Brzezinski, Jennifer L AU - Craft, David L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, Ohio 45237, USA. jennifer.brzezinski@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2377 EP - 2382 VL - 70 IS - 10 SN - 0362-028X, 0362-028X KW - Ricin KW - 9009-86-3 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Sensitivity and Specificity KW - Dose-Response Relationship, Drug KW - Humans KW - Biological Assay KW - Colorimetry KW - Bioterrorism KW - L-Lactate Dehydrogenase -- metabolism KW - Jurkat Cells -- drug effects KW - Castor Bean -- chemistry KW - Beverages -- analysis KW - Jurkat Cells -- enzymology KW - Food Contamination -- analysis KW - Ricin -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68443943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Evaluation+of+an+in+vitro+bioassay+for+the+detection+of+purified+ricin+and+castor+bean+in+beverages+and+liquid+food+matrices.&rft.au=Brzezinski%2C+Jennifer+L%3BCraft%2C+David+L&rft.aulast=Brzezinski&rft.aufirst=Jennifer&rft.date=2007-10-01&rft.volume=70&rft.issue=10&rft.spage=2377&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. AN - 68440943; 17962618 AB - On October 6, 2006, the U.S. Food and Drug Administration granted regular approval to vorinostat (Zolinza(R); Merck & Co., Inc., Whitehouse Station, NJ), a histone deacetylase inhibitor, for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease on or following two systemic therapies. The pivotal study supporting approval was a single-arm open-label phase II trial that enrolled 74 patients with stage IB and higher CTCL who had failed two systemic therapies (one of which must have contained bexarotene). Patients received vorinostat at a dose of 400 mg orally once daily, which could be reduced for toxicity to 300 mg daily or 300 mg 5 days a week. The median age of patients was 61 years. Sixty-one patients (82%) had stage IIB or higher CTCL and 30 patients (41%) had Sézary syndrome. The median duration of protocol treatment was 118 days. The primary efficacy endpoint was objective response assessed by the Severity-Weighted Assessment Tool. The objective response rate was 30% (95% confidence interval [CI], 19.7%-41.5%), the estimated median response duration was 168 days, and the median time to tumor progression was 202 days. An additional single-center study enrolled 33 patients with similar baseline and demographic features as the pivotal trial. Thirteen of the 33 received vorinostat (400 mg/day). The response rate in these 13 patients was 31% (95% CI, 9.1%-61.4%). The most common clinical adverse events (AEs) of any grade were diarrhea (52%), fatigue (52%), nausea (41%), and anorexia (24%). Grade 3 or 4 clinical AEs included fatigue (4%) and pulmonary embolism (5%). Hematologic laboratory abnormalities included thrombocytopenia (26%) and anemia (14%). Chemistry laboratory abnormalities included increased creatinine (16%), increased serum glucose (69%), and proteinuria (51%). Most abnormalities were National Cancer Institute Common Terminology Criteria for Adverse Events grade 1 or 2. Grade 3 or greater chemistry abnormalities included hyperglycemia, hypertriglyceridemia, and hyperuricemia, hypoglycemia, hypokalemia, hyponatremia, hyperkalemia, hypercholesterolemia, hypophosphatemia, and increased creatinine. JF - The oncologist AU - Mann, Bhupinder S AU - Johnson, John R AU - Cohen, Martin H AU - Justice, Robert AU - Pazdur, Richard AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA. bhupinder.mann@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1247 EP - 1252 VL - 12 IS - 10 SN - 1083-7159, 1083-7159 KW - Antineoplastic Agents KW - 0 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - vorinostat KW - 58IFB293JI KW - Index Medicus KW - United States KW - Administration, Oral KW - Neoplasm Staging KW - Dose-Response Relationship, Drug KW - Humans KW - Salvage Therapy KW - Aged KW - Drug Resistance, Neoplasm KW - United States Food and Drug Administration KW - Survival Rate KW - Aged, 80 and over KW - Drug Approval KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Maximum Tolerated Dose KW - Female KW - Male KW - Skin Neoplasms -- drug therapy KW - Hydroxamic Acids -- therapeutic use KW - Skin Neoplasms -- pathology KW - Lymphoma, T-Cell, Cutaneous -- pathology KW - Antineoplastic Agents -- therapeutic use KW - Lymphoma, T-Cell, Cutaneous -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68440943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+approval+summary%3A+vorinostat+for+treatment+of+advanced+primary+cutaneous+T-cell+lymphoma.&rft.au=Mann%2C+Bhupinder+S%3BJohnson%2C+John+R%3BCohen%2C+Martin+H%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Mann&rft.aufirst=Bhupinder&rft.date=2007-10-01&rft.volume=12&rft.issue=10&rft.spage=1247&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inter-rater agreement for a retrospective exposure assessment of asbestos, chromium, nickel and welding fumes in a study of lung cancer and ionizing radiation. AN - 68402303; 17846032 AB - A retrospective exposure assessment of asbestos, welding fumes, chromium and nickel (in welding fumes) was conducted at the Portsmouth Naval Shipyard for a nested case-control study of lung cancer risk from external ionizing radiation. These four contaminants were included because of their potential to confound or modify the effect of a lung cancer-radiation relationship. The exposure assessment included three experienced industrial hygienists from the shipyard who independently assessed exposures for 3519 shop/job/time period combinations. A consensus process was used to resolve estimates with large differences. Final exposure estimates were linked to employment histories of the 4388 study subjects to calculate their cumulative exposures. Inter-rater agreement analyses were performed on the original estimates to better understand the estimation process. Although concordance was good to excellent (78-99%) for intensity estimates and excellent (96-99%) for frequency estimates, overall simple kappa statistics indicated only slight agreement beyond chance (kappa < 0.2). Unbalanced distributions of exposure estimates partly contributed to the weak observed overall inter-rater agreement. Pairwise weighted kappa statistics revealed better agreement between two of the three panelists (kappa = 0.19-0.65). The final consensus estimates were similar to the estimates made by these same two panelists. Overall welding fume exposures were fairly stable across time at the shipyard while asbestos exposures were higher in the early years and fell in the mid-1970s. Mean cumulative exposure for all study subjects was 520 fiber-days cc(-1) for asbestos and 1000 mg-days m(-3) for welding fumes. Mean exposure was much lower for nickel (140 microg-days m(-3)) and chromium (45 microg-days m(-3)). Asbestos and welding fume exposure estimates were positively associated with lung cancer in the nested case-control study. The radiation-lung cancer relationship was attenuated by the inclusion of these two confounders. This exposure assessment provided exposure estimates that aided in understanding of the lung cancer-radiation relationship at the shipyard. JF - The Annals of occupational hygiene AU - Seel, E A AU - Zaebst, D D AU - Hein, M J AU - Liu, J AU - Nowlin, S J AU - Chen, P AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. lseel@cdc.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 601 EP - 610 VL - 51 IS - 7 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Chromium KW - 0R0008Q3JB KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Asbestos -- analysis KW - Chromium -- analysis KW - Humans KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Welding KW - Observer Variation KW - Lung Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- etiology KW - Air Pollutants, Occupational -- analysis KW - Occupational Diseases -- etiology KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68402303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Inter-rater+agreement+for+a+retrospective+exposure+assessment+of+asbestos%2C+chromium%2C+nickel+and+welding+fumes+in+a+study+of+lung+cancer+and+ionizing+radiation.&rft.au=Seel%2C+E+A%3BZaebst%2C+D+D%3BHein%2C+M+J%3BLiu%2C+J%3BNowlin%2C+S+J%3BChen%2C+P&rft.aulast=Seel&rft.aufirst=E&rft.date=2007-10-01&rft.volume=51&rft.issue=7&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-16 N1 - Date created - 2007-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. AN - 68396079; 17938735 AB - Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation. During cadmium-induced malignant transformation, an unusual pattern of genomic hypermethylation occurred that we studied to provide insight into the roles of specific DNMTs in oncogenesis. Gene expression and DNA methylation were assessed in control and chronic cadmium-transformed prostate epithelial cells (CTPE) using reverse transcription-polymerase chain reaction (RT-PCR), Western blot analysis, methylation-specific PCR, and methyl acceptance assay. During the 10-weeks of cadmium exposure that induced malignant transformation, progressive increases in generalized DNMT enzymatic activity occurred that were associated with over-expression of DNMT3b without changes in DNMT1 expression. Increased DNMT3b expression preceded increased DNMT enzymatic activity. Procainamide, a specific DNMT1 inhibitor, reversed cadmium-induced genomic DNA hypermethylation. Reduced expression of the tumor suppressor genes, RASSF1A and p16, began about the time DNMT3b overexpression first occurred and progressively decreased thereafter. RASSF1A and p16 promoter regions were heavily methylated in CTPE cells, indicating silencing by hypermethylation, while the DNA demethylating agent, 5-aza-2'-deoxycytidine, reversed this silencing. DNMT1 inhibition only modestly increased RASSF1A and p16 expression in CTPE cells and did not completely reverse silencing. These data indicate that DNMT3b overexpression can result in generalized DNA hypermethylation and gene silencing but that DNMT1 is required to maintain these effects. The pattern of genomic DNA hypermethylation together with up-regulation of DNMT3b may provide a unique set of biomarkers to specifically identify cadmium-induced human prostate cancers. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Waterland, Robert A AU - Dill, Anna L AU - Webber, Mukta M AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1454 EP - 1459 VL - 115 IS - 10 SN - 0091-6765, 0091-6765 KW - Carcinogens, Environmental KW - 0 KW - Cadmium KW - 00BH33GNGH KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - DNA methyltransferase 3B KW - Index Medicus KW - prostate KW - p16 KW - carcinogenesis KW - DNMT3b KW - cadmium KW - DNA methylation KW - RASSF1A KW - Gene Expression Profiling KW - Epithelial Cells -- drug effects KW - Genes, Tumor Suppressor -- drug effects KW - DNA (Cytosine-5-)-Methyltransferase -- drug effects KW - Cells, Cultured KW - Humans KW - Case-Control Studies KW - Up-Regulation KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - Male KW - Prostate -- drug effects KW - DNA Methylation -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Cadmium -- toxicity KW - Gene Expression Regulation -- drug effects KW - Carcinogens, Environmental -- toxicity KW - Prostate -- cytology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68396079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Tumor+suppressor+gene+inactivation+during+cadmium-induced+malignant+transformation+of+human+prostate+cells+correlates+with+overexpression+of+de+novo+DNA+methyltransferase.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BWaterland%2C+Robert+A%3BDill%2C+Anna+L%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2007-10-01&rft.volume=115&rft.issue=10&rft.spage=1454&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2004 Sep 20;1704(2):87-102 [15363862] Clin Cancer Res. 2003 Oct 1;9(12):4415-22 [14555514] Biochem Biophys Res Commun. 1993 Jun 30;193(3):1184-90 [8323540] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9821-6 [8790415] Adv Cancer Res. 1998;72:141-96 [9338076] Nat Genet. 1998 Jul;19(3):219-20 [9662389] Nucleic Acids Res. 1999 Jun 1;27(11):2291-8 [10325416] J Clin Oncol. 2004 Nov 15;22(22):4632-42 [15542813] Int J Cancer. 2005 Jan 20;113(3):440-5 [15455389] Clin Cancer Res. 2004 Dec 15;10(24):8472-8 [15623627] J Natl Cancer Inst. 2005 Jan 19;97(2):103-15 [15657340] Gynecol Oncol. 2005 Feb;96(2):531-8 [15661247] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] Cancer Lett. 2005 Aug 8;226(1):77-84 [16004934] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Oral Oncol. 2006 Jan;42(1):5-13 [15978859] Cancer Res. 2006 Jan 15;66(2):729-35 [16424002] Endocr Relat Cancer. 2006 Jun;13(2):357-77 [16728568] Prostate. 2007 Feb 1;67(2):135-45 [17075824] Cell. 1999 Oct 29;99(3):247-57 [10555141] Cytogenet Cell Genet. 1999;86(3-4):333-4 [10575238] Nature. 2000 Apr 27;404(6781):1003-7 [10801130] J Environ Pathol Toxicol Oncol. 2000;19(3):307-18 [10983897] Cancer Res. 2001 Jan 15;61(2):455-8 [11212230] Nature. 2002 Apr 4;416(6880):552-6 [11932749] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Cancer Res. 2002 Jun 15;62(12):3498-502 [12067994] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10060-5 [12110732] J Biol Chem. 2002 Aug 2;277(31):28176-81 [12015329] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Mol Cell Biol. 2003 Aug;23(16):5594-605 [12897133] Cancer Cells. 1991 Oct;3(10):383-90 [1777359] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The US national antimicrobial resistance monitoring system. AN - 68374886; 17927472 AB - The use of antimicrobial agents in food animals can select for resistant bacterial pathogens that may be transmitted to humans via the commercial meat supply. In the USA, the FDA's Center for Veterinary Medicine regulatory duties require a determination that antimicrobial drugs are safe and effective for use in food animals. In addition, a qualitative assessment of risks to human health from antimicrobial resistance requires development. This risk assessment process is supported by data generated by the FDA's National Antimicrobial Resistance Monitoring System (NARMS) for enteric bacteria. NARMS data on antimicrobial susceptibility among Salmonella, Campylobacter, Escherichia coli and Enterococcus is collected. Research activities defining the genetic bases of resistance helps to understand the potential public health risks posed by the spread of antimicrobial resistance from food animal antimicrobial use. These activities help insure that antimicrobials are used judiciously to promote human and animal health. JF - Future microbiology AU - Gilbert, Jeffrey M AU - White, David G AU - McDermott, Patrick F AD - Center for Veterinary Medicine, US FDA, Office of New Animal Drug Evaluation 7500 Standish Place Rockville, MD 20855, USA. jeff.gilbert@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 493 EP - 500 VL - 2 IS - 5 KW - Anti-Infective Agents KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Animal Feed KW - United States Food and Drug Administration KW - Gram-Positive Bacterial Infections -- microbiology KW - Humans KW - Gram-Positive Bacteria -- growth & development KW - Gram-Negative Bacteria -- growth & development KW - Food Contamination KW - Gram-Negative Bacterial Infections -- microbiology KW - Food Microbiology KW - Drug Resistance, Microbial KW - Anti-Infective Agents -- administration & dosage KW - Meat -- microbiology KW - Food -- standards KW - Animals, Domestic -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68374886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+microbiology&rft.atitle=The+US+national+antimicrobial+resistance+monitoring+system.&rft.au=Gilbert%2C+Jeffrey+M%3BWhite%2C+David+G%3BMcDermott%2C+Patrick+F&rft.aulast=Gilbert&rft.aufirst=Jeffrey&rft.date=2007-10-01&rft.volume=2&rft.issue=5&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Future+microbiology&rft.issn=1746-0921&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Investigation of reagent distributions on glass fiber membrane filters used in air sampling. AN - 68338770; 17909647 AB - This project has arisen from the need to produce GFFs (glass fiber filters) bearing a thin and evenly distributed coating of a selected reagent in the equatorial plane for breakthrough studies. However, it has been discovered that today's two general techniques for coating GFFs (total immersion and application of reagent solution to GFFs) have usually produced unevenly distributed coatings of reagent in the equatorial plane. In addition, quantities of reagent on GFFs from commercial sources may vary widely in the same lot of coated GFFs. Consequences are variability in capacity of coated filters at the point of breakthrough and, perhaps, wasted reagent. Although today's reagent-coated filters may be satisfactory for routine air sampling, such filters may be unacceptable for precise breakthrough studies. Research has been conducted successfully to produce nearly evenly distributed coatings of reagents in the equatorial plane of GFFs by application of reagent solutions to the centers of GFFs which are resting on crisscrossing, fine, stainless-steel wire. Distributions of coatings have been determined by punching out twenty-one 5-mm circles from each GFF and analyzing each circle by flow-injection with a UV detector. Lowest achievable relative standard deviations of measurement (RSDs) for reagents in 5-mm circles have been 5 to 7%. Reagents studied have included 1-(2-pyridyl)piperazine (1-2PP), 2,4-dinitrophenylhydrazine (DNPH), and 1-(9-anthracenylmethyl)piperazine (MAP). Factors affecting the distribution of such coatings include choice of reagent and choice of solvent for the reagent solution. JF - Journal of environmental monitoring : JEM AU - Tucker, Samuel P AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. spt1@cdc.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1122 EP - 1130 VL - 9 IS - 10 SN - 1464-0325, 1464-0325 KW - 1-(9-anthracenylmethyl)piperazine KW - 0 KW - Anthracenes KW - Indicators and Reagents KW - Membranes, Artificial KW - Phenylhydrazines KW - Phosphoric Acids KW - Piperazines KW - Solutions KW - fiberglass KW - 2,4-dinitrophenylhydrazine KW - 1N39KD7QPJ KW - phosphoric acid KW - E4GA8884NN KW - Index Medicus KW - Filtration KW - Piperazines -- chemistry KW - Anthracenes -- chemistry KW - Phenylhydrazines -- chemistry KW - Indicators and Reagents -- chemistry KW - Wettability KW - Phosphoric Acids -- chemistry KW - Glass -- chemistry KW - Air -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Investigation+of+reagent+distributions+on+glass+fiber+membrane+filters+used+in+air+sampling.&rft.au=Tucker%2C+Samuel+P&rft.aulast=Tucker&rft.aufirst=Samuel&rft.date=2007-10-01&rft.volume=9&rft.issue=10&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-25 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk assessment to guide the prevention of cervical cancer. AN - 68337330; 17904958 AB - Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (eg, cytology, carcinogenic HPV testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk. JF - American journal of obstetrics and gynecology AU - Castle, Philip E AU - Sideri, Mario AU - Jeronimo, Jose AU - Solomon, Diane AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 356.e1 EP - 6 VL - 197 IS - 4 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Risk Management KW - Models, Statistical KW - Female KW - Risk Assessment KW - Papillomaviridae -- growth & development KW - Papillomavirus Infections -- pathology KW - Uterine Cervical Neoplasms -- prevention & control KW - Cervical Intraepithelial Neoplasia -- pathology KW - Cervical Intraepithelial Neoplasia -- prevention & control KW - Precancerous Conditions -- prevention & control KW - Papillomavirus Infections -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Uterine Cervical Neoplasms -- pathology KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68337330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2007-10-01&rft.volume=197&rft.issue=4&rft.spage=356.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving depiction of benefits and harms: analyses of studies of well-known therapeutics and review of high-impact medical journals. AN - 68337221; 17909378 AB - The issues of weighing benefits and harms and of shared decision-making have become increasingly important in recent years. There is limited knowledge and lack of adequate data on the most transparent method of communicating the information. In this article we discuss examples of communicating benefits and harms for well-known therapeutics, illustrating that relative risk estimates are not helpful for communicating the chance of experiencing adverse events. In addition, we show that asymmetric presentation of the data for benefits and harms is likely to bias toward showing greater benefits and diminishing the importance of the harms (or vice versa). We also present preliminary results of a brief review of high-impact medical journals that show limitations of current systematic reviews. In the review we found that every second published study does not discuss frequency data and 1 in 3 studies that report information on both benefits and harms does not report information in the same metric. We conclude that consistently depicting benefit and harm information in frequencies can substantially improve the communication of benefits and harms. Investigators should be requested to provide frequency data along with relative risk information in the publication of their scientific findings. Currently, even in the highest impact medical journals, evidence of benefits and harms is not consistently presented in ways that facilitate accurate interpretation. JF - Medical care AU - Sedrakyan, Artyom AU - Shih, Chuck AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. asedraky@ahrq.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - S23 EP - S28 VL - 45 IS - 10 Supl 2 SN - 0025-7079, 0025-7079 KW - Antipsychotic Agents KW - 0 KW - Appetite Depressants KW - Aspirin, Dipyridamole Drug Combination KW - Contraceptives, Oral KW - Drug Combinations KW - Fibrinolytic Agents KW - Phenylpropanolamine KW - 33RU150WUN KW - Dipyridamole KW - 64ALC7F90C KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Contraceptives, Oral -- adverse effects KW - Fibrinolytic Agents -- therapeutic use KW - Phenylpropanolamine -- adverse effects KW - Stroke -- therapy KW - Appetite Depressants -- adverse effects KW - Humans KW - Pharmacoepidemiology KW - Risk Assessment KW - Stroke -- epidemiology KW - Tissue Plasminogen Activator -- therapeutic use KW - Hormone Replacement Therapy -- adverse effects KW - Aspirin -- therapeutic use KW - Dipyridamole -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Stroke -- chemically induced KW - Review Literature as Topic KW - Drug Evaluation KW - Evidence-Based Medicine KW - Information Dissemination KW - Decision Making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68337221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Improving+depiction+of+benefits+and+harms%3A+analyses+of+studies+of+well-known+therapeutics+and+review+of+high-impact+medical+journals.&rft.au=Sedrakyan%2C+Artyom%3BShih%2C+Chuck&rft.aulast=Sedrakyan&rft.aufirst=Artyom&rft.date=2007-10-01&rft.volume=45&rft.issue=10+Supl+2&rft.spage=S23&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-20 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The concomitant prescribing of ethinyl estradiol/drospirenone and potentially interacting drugs. AN - 68324295; 17900437 AB - Ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/DRSP) contains a progestin drospirenone with antimineralocorticoid properties that may cause potassium retention leading to hyperkalemia. We estimated the percentage of EE/DRSP users prescribed concomitant potassium-sparing drugs [nonsteroidal antiinflammatory drugs, diuretics, angiotensin-converting enzyme inhibitors (with diuretics), angiotensin II agonists (with diuretics), and potassium chloride] between January 1, 2002, and March 31, 2005. We analyzed a population-based data set of 62,527 EE/DRSP users (Dimension Rx, Caremark). We compared the fill date and end date for each prescription (Rx) for an interacting drug to the start and end date for each EE/DRSP episode (linked Rxs). If a day of an interacting Rx overlapped with an EE/DRSP episode, concomitant prescribing was recorded. A total of 17.6% of the women concomitantly used EE/DRSP and an interacting drug. Twenty-nine percent of concomitant use occurred within a month of EE/DRSP initiation. Nonsteroidal antiinflammatory drugs and diuretics were most frequently used concomitantly with EE/DRSP. Forty percent of the women with concomitant use were 35 yearsof age or older at EE/DRSP initiation compared with 29% without concomitant use (p<.001). Obstetricians/gynecologists and family practitioners were the most common prescribers of EE/DRSP and potassium-sparing drugs, respectively. Concomitant prescribing of EE/DRSP and potassium-sparing drugs occurred frequently in our study population. As EE/DRSP becomes more widely used, physicians prescribing it should monitor patients for potassium-sparing drug use. JF - Contraception AU - McAdams, Mara AU - Staffa, Judy A AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. mara.mcadams@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 278 EP - 281 VL - 76 IS - 4 SN - 0010-7824, 0010-7824 KW - Androstenes KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Contraceptives, Oral, Hormonal KW - Drug Combinations KW - Mineralocorticoid Receptor Antagonists KW - Sodium Channel Blockers KW - Ethinyl Estradiol KW - 423D2T571U KW - drospirenone KW - N295J34A25 KW - Index Medicus KW - Drug Interactions KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Retrospective Studies KW - Contraceptives, Oral, Hormonal -- adverse effects KW - Practice Patterns, Physicians' -- statistics & numerical data KW - Medical Audit KW - Adult KW - Cohort Studies KW - Databases, Factual KW - Contraceptives, Oral, Hormonal -- therapeutic use KW - Female KW - Sodium Channel Blockers -- therapeutic use KW - Androstenes -- therapeutic use KW - Mineralocorticoid Receptor Antagonists -- therapeutic use KW - Ethinyl Estradiol -- adverse effects KW - Androstenes -- adverse effects KW - Hyperkalemia -- prevention & control KW - Hyperkalemia -- chemically induced KW - Ethinyl Estradiol -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68324295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=The+concomitant+prescribing+of+ethinyl+estradiol%2Fdrospirenone+and+potentially+interacting+drugs.&rft.au=McAdams%2C+Mara%3BStaffa%2C+Judy+A%3BDal+Pan%2C+Gerald+J&rft.aulast=McAdams&rft.aufirst=Mara&rft.date=2007-10-01&rft.volume=76&rft.issue=4&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=00107824&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality among shipyard Coast Guard workers: a retrospective cohort study. AN - 68302992; 17881470 AB - The mortality experience of 4702 (4413 men and 289 women) civilian workers in a US Coast Guard shipyard was evaluated. All workers employed at the shipyard between 1 January 1950 and 31 December 1964 were included in the study and were followed through 31 December 2001 for vital status. Detailed shipyard and lifetime work histories found in the shipyard personnel records and job descriptions were evaluated. Workers were classified as likely exposed to any potential hazardous substances. In addition, 20 job groups were created on likely similar exposures. Standardised mortality ratios (SMRs) were calculated based on the general population of the state and adjusted for age, calendar period, sex and race. The follow-up was successful for 93.3% of the workers. Among all men employed in the shipyard, there was an excess of mortality from all causes of death (SMR 1.08; 95% CI 1.04 to 1.12), respiratory cancers (SMR 1.29; 95% CI 1.15 to 1.43), lung cancer (SMR 1.26; 95% CI 1.12 to 1.41), mesothelioma (SMR 5.07; 95% CI 1.85 to 11.03) and emphysema (SMR 1.44; 95% CI 1.01 to 1.99) and a decrease for cardiovascular diseases (OR 0.95; 95% CI 0.90 to 1.00), vascular lesions of the central nervous system (SMR 0.80; 95% CI 0.67 to 0.96), cirrhosis of the liver (SMR 0.38; 95% CI 0.25 to 0.57) and external causes of death (SMR 0.55; 95% CI 0.44 to 0.68). A similar pattern was observed for the men classified as exposed. No increasing trend of mortality was found with duration of employment in the shipyard, with the exception of mesothelioma (SMRs of 4.23 and 6.27 for or =10 years, respectively). In occupations with at least three cases and with an SMR of > or =1.3, the authors observed a significantly elevated mortality for lung cancer among machinists (SMR 1.60; 95% CI 1.08 to 2.29) and shipfitters, welders and cutters (SMR 1.34; 95% CI 1.07 to 1.65) and for oral and nasopharyngeal cancers among wood workers (SMR 6.20; 95% CI 2.27 to 13.50). Employment in this Coast Guard shipyard revealed a small but significant excess mortality from all causes, lung cancer and mesothelioma, most of which is probably related to asbestos exposure. JF - Occupational and environmental medicine AU - Krstev, S AU - Stewart, P AU - Rusiecki, J AU - Blair, A AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 651 EP - 658 VL - 64 IS - 10 KW - Index Medicus KW - Causality KW - Occupational Exposure -- statistics & numerical data KW - Neoplasms -- mortality KW - Humans KW - Retrospective Studies KW - Aged KW - Baltimore -- epidemiology KW - Employment -- statistics & numerical data KW - Cardiovascular Diseases -- mortality KW - Continental Population Groups -- statistics & numerical data KW - Adult KW - Cohort Studies KW - Middle Aged KW - Respiratory Tract Diseases -- mortality KW - Sex Distribution KW - Female KW - Male KW - Ships KW - Military Personnel -- statistics & numerical data KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Mortality+among+shipyard+Coast+Guard+workers%3A+a+retrospective+cohort+study.&rft.au=Krstev%2C+S%3BStewart%2C+P%3BRusiecki%2C+J%3BBlair%2C+A&rft.aulast=Krstev&rft.aufirst=S&rft.date=2007-10-01&rft.volume=64&rft.issue=10&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Ind Med. 2003 Apr;43(4):350-60 [12645092] Ind Health. 2003 Apr;41(2):94-100 [12725469] Cancer Causes Control. 2003 Apr;14(3):203-12 [12814199] Semin Nephrol. 2003 Sep;23(5):500-8 [13680539] Respir Care. 2003 Dec;48(12):1185-91; discussion 1191-3 [14651759] Cancer Causes Control. 2004 Apr;15(3):285-94 [15090723] Am J Ind Med. 2004 Jun;45(6):483-90 [15164392] J Occup Health. 2004 Jul;46(4):266-71 [15308825] Br J Ind Med. 1972 Apr;29(2):142-5 [5021994] Environ Res. 1976 Apr;11(2):271-9 [939218] Br J Prev Soc Med. 1976 Dec;30(4):225-30 [1009272] N Engl J Med. 1978 Sep 21;299(12):620-4 [683235] Ann N Y Acad Sci. 1979;330:295-311 [294180] J Natl Cancer Inst. 1980 Sep;65(3):571-5 [6931936] Int Arch Occup Environ Health. 1985;55(4):277-83 [4008052] Cancer Res. 1985 Aug;45(8):3924-8 [4016758] Int Arch Occup Environ Health. 1987;59(5):455-62 [3653990] Am J Ind Med. 1988;13(1):105-18 [3344750] Am J Ind Med. 1988;13(1):59-69 [3344756] Am Ind Hyg Assoc J. 1988 Mar;49(3):121-7 [3376873] Br J Ind Med. 1988 Apr;45(4):209-18 [3377996] Arch Environ Health. 1989 May-Jun;44(3):150-6 [2751350] Cancer. 1989 Dec 15;64(12):2609-13 [2819671] Br J Ind Med. 1991 Mar;48(3):145-54 [2015204] Eur Respir J. 1992 Mar;5(3):281-5 [1572439] Occup Med (Lond). 1992 Nov;42(4):203-12 [1295495] Cancer Epidemiol Biomarkers Prev. 1992 Jul-Aug;1(5):345-8 [1305465] Int Arch Occup Environ Health. 1993;65(1):35-41 [8354573] Am Ind Hyg Assoc J. 1993 Jul;54(7):392-6 [8362760] Br J Ind Med. 1993 Dec;50(12):1097-103 [8280640] Ann Occup Hyg. 1995 Jun;39(3):363-74 [7793754] Chest. 1995 Sep;108(3):647-55 [7656611] J Occup Environ Med. 2000 Jan;42(1):101-9 [10652696] Am J Ind Med. 2000 May;37(5):512-21 [10723045] Occup Environ Med. 2000 Jun;57(6):376-84 [10810126] Cancer Causes Control. 2001 May;12(4):365-74 [11456233] Am J Ind Med. 2001 Oct;40(4):363-70 [11598985] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1145-53 [11700262] Am J Ind Med. 2002 Jul;42(1):11-22 [12111686] Scand J Work Environ Health. 2002 Aug;28(4):278-84 [12199430] Semin Cancer Biol. 2002 Dec;12(6):421-9 [12450728] Med Lav. 1997 Jul-Aug;88(4):316-20 [9396217] Cancer Causes Control. 1997 May;8(3):491-503 [9498906] Scand J Work Environ Health. 1998;24 Suppl 2:25-41 [9714511] Ind Health. 1999 Jan;37(1):9-17 [10052294] Environ Health Perspect. 1999 May;107 Suppl 2:289-98 [10350513] Environ Health Perspect. 2004 Nov;112(15):1539-43 [15531439] Occup Med (Lond). 2005 Mar;55(2):79-87 [15757980] Occup Environ Med. 2005 May;62(5):318-24 [15837853] J Occup Environ Med. 2006 Jan;48(1):1-12 [16404204] Comment In: Occup Environ Med. 2007 Oct;64(10):639-41 [17881468] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. AN - 68294441; 17622572 AB - Chemically modified hemoglobin (Hb) solutions are promising oxygen therapeutics; however, these agents are prone to intravascular oxidation. Using a 50% exchange transfusion (ET) model with bovine polymerized hemoglobin (PolyHbBv), we examined heme oxidation, oxygenation markers, and toxicokinetics in rats, an ascorbic acid (AA)-producing species, and in guinea pigs, a non-AA-producing species. Plasma AA decreased by 50% in guinea pigs after ET, but it was unchanged in rats for the first 20 h post-ET. Both species cleared PolyHbBv from the circulation at similar rates. However, exposure to ferric PolyHbBv over time was 5-fold greater in the guinea pig. Mass spectrometry analysis of plasma revealed oxidative modifications within the tetrameric fraction of PolyHbBv in guinea pig. Oxygen equilibrium curves of PolyHbBv measured in plasma after ET were more left-shifted in guinea pigs compared with rats, consistent with increased ferric PolyHbBv formation. Renal hypoxia-inducible factor (HIF)-1alpha, whose activity strictly depends on the partial pressure of oxygen increased over time, and it correlated inversely with circulating ferrous PolyHbBv in both species. Interestingly, HIF-1alpha activity was greater in guinea pigs compared with rats at 72 h post-ET. Mean arterial pressure increases were also greater in guinea pigs; however, minimal differences in cardiac and renal pathology were observed in either species. The present findings suggest the importance of plasma AA in maintaining the stability of acellular Hb susceptible to oxidation, and they may be relevant to humans, which display a similar plasma/tissue antioxidant status to guinea pig. JF - The Journal of pharmacology and experimental therapeutics AU - Buehler, Paul W AU - D'Agnillo, Felice AU - Hoffman, Victoria AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. paul.buehler@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 49 EP - 60 VL - 323 IS - 1 SN - 0022-3565, 0022-3565 KW - Blood Substitutes KW - 0 KW - Hemoglobins KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - polyhemoglobin KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Drug Stability KW - Kidney -- pathology KW - Guinea Pigs KW - Myocardium -- pathology KW - Kidney -- drug effects KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Rats KW - Oxidation-Reduction KW - Rats, Sprague-Dawley KW - Cattle KW - Heart Rate -- drug effects KW - Blood Pressure -- drug effects KW - Male KW - Cell-Free System KW - Hemoglobins -- pharmacokinetics KW - Blood Substitutes -- pharmacokinetics KW - Hemoglobins -- toxicity KW - Blood Substitutes -- pharmacology KW - Oxygen -- blood KW - Plasma Exchange KW - Hemoglobins -- pharmacology KW - Ascorbic Acid -- blood KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68294441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effects+of+endogenous+ascorbate+on+oxidation%2C+oxygenation%2C+and+toxicokinetics+of+cell-free+modified+hemoglobin+after+exchange+transfusion+in+rat+and+guinea+pig.&rft.au=Buehler%2C+Paul+W%3BD%27Agnillo%2C+Felice%3BHoffman%2C+Victoria%3BAlayash%2C+Abdu+I&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2007-10-01&rft.volume=323&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Investigation of protein expression in magnetic field-treated human glioma cells. AN - 68292419; 17570505 AB - We previously reported phenotypic changes in human breast cancer cells following low-level magnetic field (MF) exposure. Here proteomic methods were used to investigate the biochemical effect of MF exposure in SF767 human glioma cells. Protein alterations were studied after exposure to 1.2 microTesla (microT) MF [12 milliGauss (mG), 60 Hertz (Hz)] +/- epidermal growth factor (EGF). SF767 cells were exposed for 3 h to sham conditions (<0.2 microT ambient field strength) or 1.2 microT MF (+/-EGF; 10 ng/ml). Solubilized protein fractions (sham; 1.2 microT; sham + EGF; 1.2 microT + EGF) were loaded for electrophoresis by 2D-PAGE and stained using a colloidal Coomassie blue technique to resolve and characterize the proteins. Protein patterns were compared across groups via Student's t-test using PDQUEST software. Cell profiles revealed significant alterations in the spot density of a subset of treated cells. Automated spot excision and processing was performed prior to peptide mass fingerprinting proteins of interest. Fifty-seven proteins from the detectable pool were identified and/or found to differ significantly across treatment groups. The mean abundance of 10 identified proteins was altered following 1.2 microT exposure. In the presence of EGF six proteins were altered after low magnetic field treatment by increasing (4) or decreasing (2) in abundance. The results suggest that the analysis of differentially expressed proteins in SF767 cells may be useful as biomarkers for biological changes caused by exposure to magnetic fields. (c) 2007 Wiley-Liss, Inc. JF - Bioelectromagnetics AU - Kanitz, M H AU - Witzmann, F A AU - Lotz, W G AU - Conover, D AU - Savage, R E AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. mhk2@cdc.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 546 EP - 552 VL - 28 IS - 7 SN - 0197-8462, 0197-8462 KW - Neoplasm Proteins KW - 0 KW - Index Medicus KW - Radiation Dosage KW - Electromagnetic Fields KW - Humans KW - Cell Line, Tumor KW - Dose-Response Relationship, Radiation KW - Gene Expression Regulation, Neoplastic -- radiation effects KW - Glioma -- metabolism KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68292419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioelectromagnetics&rft.atitle=Investigation+of+protein+expression+in+magnetic+field-treated+human+glioma+cells.&rft.au=Kanitz%2C+M+H%3BWitzmann%2C+F+A%3BLotz%2C+W+G%3BConover%2C+D%3BSavage%2C+R+E&rft.aulast=Kanitz&rft.aufirst=M&rft.date=2007-10-01&rft.volume=28&rft.issue=7&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Bioelectromagnetics&rft.issn=01978462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - The Alcohol Dependence Syndrome, 30 years later: a commentary. the 2006 H. David Archibald lecture. AN - 68275691; 17680851 AB - Major classification systems for alcohol use disorders (DSM-IV and ICD-10) contain elements of the 1976 Edwards and Gross formulation of the Alcohol Dependence Syndrome (ADS). However, issues remain about the criteria that identify Alcohol Dependence (AD) as distinct from Alcohol Abuse (AA) in DSM-IV and Harmful Use in ICD-10. These issues, in part, have their roots in changing historical perceptions of alcohol use and its problems. We discuss current diagnostic criteria for AA and AD, collectively called Alcohol Use Disorders (AUDs), in the context of their historical evolution; research progress in understanding alcohol problems, including alcohol dependence; new findings on the severity of AUDs as classified by DSM-IV; and the role of alcohol consumption patterns in future classifications of AUDs. This paper is based largely on the 2006 H. David Archibald Lecture. Parts of the original lecture have been modified to reflect more recent findings from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). The original Edwards and Gross ADS construct is supported by advances in biological and behavioral science over the past 30 years. New findings indicate that DSM-IV AA and AD are not diagnostically distinct entities, but represent a continuum of severity of AUDs. The ADS criteria may best represent one quantifiable dimension of alcohol use problems and this scale can be related to that of the frequency of harmful patterns of drinking. The Edwards and Gross ADS criteria can be used as the basis for beginning the development of scalable multi-dimensional criteria for diagnosing AUDs in new initiatives to revise DSM-IV and ICD-10. JF - Addiction (Abingdon, England) AU - Li, Ting-Kai AU - Hewitt, Brenda G AU - Grant, Bridget F Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1522 EP - 1530 VL - 102 IS - 10 KW - Index Medicus KW - Factor Analysis, Statistical KW - Reproducibility of Results KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- classification KW - Terminology as Topic KW - Male KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol-Related Disorders -- classification KW - International Classification of Diseases KW - Alcohol Drinking -- adverse effects KW - Alcohol Drinking -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68275691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=The+Alcohol+Dependence+Syndrome%2C+30+years+later%3A+a+commentary.+the+2006+H.+David+Archibald+lecture.&rft.au=Li%2C+Ting-Kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-10-01&rft.volume=102&rft.issue=10&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Addiction. 2008 Feb;103(2):179-80 [18199296] Addiction. 2007 Oct;102(10):1531-2; discussion 1537-8 [17854327] Addiction. 2007 Oct;102(10):1535-7; discussion 1537-8 [17854331] Addiction. 2007 Oct;102(10):1534-5; discussion 1537-8 [17854330] Addiction. 2007 Oct;102(10):1533-4; discussion 1537-8 [17854329] Addiction. 2007 Oct;102(10):1532-3; discussion 1537-8 [17854328] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Qualitative Study of Programs for Parents with Serious Mental Illness and Their Children: Building Practice-Based Evidence AN - 57306734; 200916227 AB - The rationale for the development of effective programs for parents with serious mental illness and their children is compelling. Using qualitative methods and a grounded theory approach with data obtained in site visits, seven existing programs for parents with mental illness and their children in the United States are described and compared across core components: target population, theory and assumptions, funding, community and agency contexts, essential services and intervention strategies, moderators, and outcomes. The diversity across programs is strongly complemented by shared characteristics, the identification of which provides the foundation for future testing and the development of an evidence base. Challenges in program implementation and sustainability are identified. Qualitative methods are useful, particularly when studying existing programs, in taking steps toward building the evidence base for effective programs for parents with serious mental illness and their children. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Nicholson, Joanne AU - Hinden, Beth R AU - Biebel, Kathleen AU - Henry, Alexis D AU - Katz-Leavy, Judith AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 395 EP - 413 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 34 IS - 4 SN - 1094-3412, 1094-3412 KW - Mental health services KW - Qualitative methods KW - Mentally ill parents KW - Children KW - Service provision KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57306734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=A+Qualitative+Study+of+Programs+for+Parents+with+Serious+Mental+Illness+and+Their+Children%3A+Building+Practice-Based+Evidence&rft.au=Nicholson%2C+Joanne%3BHinden%2C+Beth+R%3BBiebel%2C+Kathleen%3BHenry%2C+Alexis+D%3BKatz-Leavy%2C+Judith&rft.aulast=Nicholson&rft.aufirst=Joanne&rft.date=2007-10-01&rft.volume=34&rft.issue=4&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-007-9063-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Qualitative methods; Mental health services; Service provision; Mentally ill parents DO - http://dx.doi.org/10.1007/s11414-007-9063-5 ER - TY - JOUR T1 - Rural Populations Are Not Protected From Drug Use and Abuse AN - 57232701; 200809692 AB - The authors provide data and analysis of drug use by geographic region in the U.S., ethnicity, and type of drug. JF - The Journal of Rural Health AU - Thomas, Yonette F AU - Compton, Wilson M AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Md Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1 EP - 3 PB - National Rural Health Association, Kansas City MO VL - 23 IS - s1 SN - 0890-765X, 0890-765X KW - Ethnicity KW - Rural communities KW - Drug abuse KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Rural+Populations+Are+Not+Protected+From+Drug+Use+and+Abuse&rft.au=Thomas%2C+Yonette+F%3BCompton%2C+Wilson+M&rft.aulast=Thomas&rft.aufirst=Yonette&rft.date=2007-10-01&rft.volume=23&rft.issue=s1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2007.00116.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Drug abuse; Rural communities; Substance abuse; Ethnicity DO - http://dx.doi.org/10.1111/j.1748-0361.2007.00116.x ER - TY - JOUR T1 - Do HMOs Reduce Preventable Hospitalizations for Medicare Beneficiaries? AN - 57230897; 200805721 AB - This study assesses the association of HMO enrollment with preventable hospitalizations among the elderly in four states. Using 2001 hospital discharge abstracts for elderly Medicare enrollees (age 65 and above) residing in four states (New York, Pennsylvania, Florida, and California), from the Healthcare Cost and Utilization Project (HCUP-SID) database of the Agency for Healthcare Research and Quality, we use a multivariate cross-sectional design with patient-level data for each state. Holding other factors such as demographics and illness severity constant, we find that in three out of four states, Medicare HMO patients had lower odds of a preventable admission versus marker admission than Medicare fee-for-service (FFS) patients. Moreover, in the two states with longest tenure and greatest Medicare HMO penetration, California and Florida, the reduction in preventable admissions among Medicare HMO patients was mainly concentrated among more ill patients. These findings add to the evidence that managed care outperforms traditional care among the elderly, rather than simply skimming off the healthiest populations. [Copyright 2007 Sage Publications, Inc.] JF - Medical Care Research and Review AU - Basu, Jayasree AU - Mobley, Lee R AD - Agency for Healthcare Research and Quality jayasree.basu@ahrq.hhs.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 544 EP - 567 PB - Sage Publications, Thousand Oaks CA VL - 64 IS - 5 SN - 1077-5587, 1077-5587 KW - Admissions KW - Managed care KW - Elderly people KW - Medicare KW - Health maintenance organizations KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57230897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Do+HMOs+Reduce+Preventable+Hospitalizations+for+Medicare+Beneficiaries%3F&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-10-01&rft.volume=64&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558707301955 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Elderly people; Managed care; Health maintenance organizations; Hospitals; Admissions; Medicare DO - http://dx.doi.org/10.1177/1077558707301955 ER - TY - JOUR T1 - Biased Emotional Attention in Post-Traumatic Stress Disorder: A Help As Well As a Hindrance? AN - 57212902; 200808713 AB - Background From a cognitive neuroscience perspective, the emotional attentional bias in post-traumatic stress disorder (PTSD) could be conceptualized either as emotional hyper-responsiveness or as reduced priming of task-relevant representations due to dysfunction in top-down regulatory systems. We investigated these possibilities both with respect to threatening and positive stimuli among traumatized individuals with and without PTSD. Method: Twenty-two patients with PTSD, 21 trauma controls and 20 non- traumatized healthy participants were evaluated on two tasks. For one of these tasks, the affective Stroop task (aST), the emotional stimuli act as distracters and interfere with task performance. For the other, the emotional lexical decision task (eLDT), emotional information facilitates task performance. Results: Compared to trauma controls and healthy participants, patients with PTSD showed increased interference for negative but not positive distracters on the aST and increased emotional facilitation for negative words on the eLDT. Conclusions: These findings document that hyper-responsiveness to threat but not to positive stimuli is specific for patients with PTSD. Adapted from the source document. JF - Psychological Medicine AU - Vythilingam, M AU - Blair, K S AU - McCaffrey, D AU - Scaramozza, M AU - Jones, M AU - Nakic, M AU - Mondillo, K AU - Hadd, K AU - Bonne, O AU - Mitchell, D G V AU - Pine, D S AU - Charney, D S AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1445 EP - 1455 PB - Cambridge University Press, UK VL - 37 IS - 10 SN - 0033-2917, 0033-2917 KW - Hypersensitivity KW - Posttraumatic stress disorder KW - Attentional bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57212902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Biased+Emotional+Attention+in+Post-Traumatic+Stress+Disorder%3A+A+Help+As+Well+As+a+Hindrance%3F&rft.au=Vythilingam%2C+M%3BBlair%2C+K+S%3BMcCaffrey%2C+D%3BScaramozza%2C+M%3BJones%2C+M%3BNakic%2C+M%3BMondillo%2C+K%3BHadd%2C+K%3BBonne%2C+O%3BMitchell%2C+D+G+V%3BPine%2C+D+S%3BCharney%2C+D+S%3BBlair%2C+R+J+R&rft.aulast=Vythilingam&rft.aufirst=M&rft.date=2007-10-01&rft.volume=37&rft.issue=10&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329170700092X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Attentional bias; Hypersensitivity DO - http://dx.doi.org/10.1017/S003329170700092X ER - TY - JOUR T1 - Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin AN - 57092654; 200802038 AB - To examine the effect of reinforcer density in prize-based abstinence reinforcement, heroin/cocaine users (N = 116) in methadone maintenance (100 mg/day) were randomly assigned to a noncontingent control group (NonC) or to 1 of 3 groups that earned prize draws for abstinence: manual drawing with standard prize density (MS) or computerized drawing with standard (CS) or high (CH) density. Probabilities (prizes/draw) were standard (50%) and high (78%); prize density was double blind. Mean prize values were CH, $286; CS, $167; MS, $139; and NonC, $171. Outcomes were % opioid/cocaine-negative urines during the 12-week intervention and then 8 weeks postintervention as well as diagnosis of dependence up to 6 months poststudy. CH had significantly more negative specimens than did NonC during intervention and had more than all groups during postintervention treatment: Mean % negative (95% confidence interval) during postintervention treatment adjusted for baseline drug use and dropout were CH, 55% (14%-90%); CS, 7% (1%-27%); MS, 4% (1%-12%); and NonC, 3% (1%-10%). Current cocaine dependence diagnoses after treatment were significantly lower in contingent compared with noncontingent groups. Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits. [Copyright 2007 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Ghitza, Udi E AU - Epstein, David H AU - Schmittner, John AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institute of Health (NIH)/Department of Health and Human Services (DHHS), Baltimore, MD, US Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 765 EP - 774 PB - American Psychological Association, Washington DC VL - 75 IS - 5 SN - 0022-006X, 0022-006X KW - Abstinence KW - Heroin KW - Interventions KW - Reinforcement KW - Cocaine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Randomized+trial+of+prize-based+reinforcement+density+for+simultaneous+abstinence+from+cocaine+and+heroin&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BSchmittner%2C+John%3BVahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-10-01&rft.volume=75&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Reinforcement; Abstinence; Cocaine; Heroin; Interventions ER - TY - JOUR T1 - The correlation of youth physical activity with state policies AN - 36942577; 3756927 AB - Childhood overweight has risen dramatically in the United States during the past three decades. The search for policy solutions is limited by a lack of evidence regarding the effectiveness of state policies for increasing physical activity among youths. This paper estimates the correlation of student physical activity with a variety of state policies. We study nationwide data on high school students from the Youth Risk Behavior Surveillance System for 1999, 2001, and 2003 merged with data on state policies from several sources. We control for a variety of characteristics of states and students to mitigate bias due to the endogenous selection of policies, but we conservatively interpret our results as correlations, not causal impacts. Two policies are positively correlated with participation in physical education (PE) class for both boys and girls: a binding PE unit requirement and a state PE curriculum. We also find that state spending on parks and recreation is positively correlated with two measures of girls' overall physical activity. Reprinted by permission of Oxford University Press JF - Contemporary economic policy AU - Cawley, John AU - Meyerhoefer, Chad AU - Newhouse, David AD - Cornell University ; US Agency for Healthcare Research and Quality ; International Monetary Fund Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 506 EP - 517 VL - 25 IS - 4 SN - 1074-3529, 1074-3529 KW - Economics KW - Political Science KW - Obesity KW - Education policy KW - Physical activity KW - Economics of sport KW - Health policy KW - U.S.A. KW - Students KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36942577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contemporary+economic+policy&rft.atitle=The+correlation+of+youth+physical+activity+with+state+policies&rft.au=Cawley%2C+John%3BMeyerhoefer%2C+Chad%3BNewhouse%2C+David&rft.aulast=Cawley&rft.aufirst=John&rft.date=2007-10-01&rft.volume=25&rft.issue=4&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Contemporary+economic+policy&rft.issn=10743529&rft_id=info:doi/10.1111%2Fj.1465-7287.2007.00070.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4035 7337 4032 3198 4025; 8823; 10449 5772; 9506; 12334 4049; 5788 11888 10472; 4056 11888 10472; 433 293 14 DO - http://dx.doi.org/10.1111/j.1465-7287.2007.00070.x ER - TY - JOUR T1 - Sport and public policy AN - 36937324; 3756939 JF - Contemporary economic policy AU - Stevenson, Betsey AU - Cawley, John AU - Meyerhoefer, Chad AU - Newhouse, David AU - Downward, Paul AU - Riordan, Joseph AU - Humphreys, Brad R AU - Ruseski, Jane E AU - Johnson, Bruce K AU - Whitehead, John C AU - Mason, Daniel S AU - Walker, Gordon J AU - Coates, Dennis AU - Maennig, Wolfgang AU - Plessis, Stan du AU - Baade, Robert A AU - Matheson, Victor A AU - Dilger, Alexander AU - Frick, Bernd AU - Tolsdorf, Frank AU - Szymanski, Stefan AU - Ross, Stephen F AU - Dehring, Carolyn A AU - Depken, Craig A AU - Ward, Michael R AU - Ross, Justin M AU - Dunn, Robert R AD - University of Pennsylvania ; Cornell University ; US Agency for Healthcare Research and Quality ; International Monetary Fund ; Loughborough University ; University of Hertfordshire ; University of Alberta ; Appalachian State University ; University of Maryland ; Universität Hamburg ; Stellenbosch University ; Lake Forest College ; College of the Holy Cross ; Westfälische Wilhelms-Universität Münster ; Universität Paderborn ; Universität Witten/Herdecke ; Imperial College London ; Penn State University ; University of Georgia ; University of North Carolina, Charlotte ; University of Texas, Arlington ; West Virginia University Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 483 EP - 655 VL - 25 IS - 4 SN - 1074-3529, 1074-3529 KW - Economics KW - Hurricane Katrina KW - World Cup KW - Major League Baseball KW - Dallas KW - New Orleans KW - Canada KW - Public infrastructure KW - Secondary schools KW - Regulatory policy KW - Physical activity KW - Social interaction KW - Baseball KW - Public management KW - Drug abuse KW - Sports KW - Alberta KW - Real estate market KW - Project management KW - Public health KW - Education policy KW - Housing prices KW - Vertical integration KW - Civil rights KW - Housing market KW - South Africa KW - Louisiana KW - Regional development KW - Public spaces KW - Obesity KW - Income elasticity KW - Economic efficiency KW - Economics of sport KW - Texas KW - U.S.A. KW - Students KW - Willingness-to-pay KW - Natural disasters KW - Recreation KW - Schools KW - Local economy KW - Legislation KW - Athletes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36937324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contemporary+economic+policy&rft.atitle=Sport+and+public+policy&rft.au=Stevenson%2C+Betsey%3BCawley%2C+John%3BMeyerhoefer%2C+Chad%3BNewhouse%2C+David%3BDownward%2C+Paul%3BRiordan%2C+Joseph%3BHumphreys%2C+Brad+R%3BRuseski%2C+Jane+E%3BJohnson%2C+Bruce+K%3BWhitehead%2C+John+C%3BMason%2C+Daniel+S%3BWalker%2C+Gordon+J%3BCoates%2C+Dennis%3BMaennig%2C+Wolfgang%3BPlessis%2C+Stan+du%3BBaade%2C+Robert+A%3BMatheson%2C+Victor+A%3BDilger%2C+Alexander%3BFrick%2C+Bernd%3BTolsdorf%2C+Frank%3BSzymanski%2C+Stefan%3BRoss%2C+Stephen+F%3BDehring%2C+Carolyn+A%3BDepken%2C+Craig+A%3BWard%2C+Michael+R%3BRoss%2C+Justin+M%3BDunn%2C+Robert+R&rft.aulast=Stevenson&rft.aufirst=Betsey&rft.date=2007-10-01&rft.volume=25&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Contemporary+economic+policy&rft.issn=10743529&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 12 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4035 7337 4032 3198 4025; 12132 7336 3198; 11324; 11408 11324; 2309 11032 9705; 4056 11888 10472; 7321; 8823; 10449 5772; 9506; 12334 4049; 11860 11907; 10663 7336 3198; 10486; 13567 13219 13221; 7501 8503; 10453; 10709 3483; 3923; 10326 7625; 8559 3601; 10460 7625; 1365 556; 3742 1121 11776 3753 3755; 13288 6599; 10745 7584 3977 5574 10472; 6065 10107; 6060 7711; 10632 10630 10339; 1493 12132 7336 3198; 6275 6271; 433 293 14; 220 433 293 14; 419 433 293 14; 385 395 2; 7 75 293 14 ER - TY - JOUR T1 - Gauge repeatability and reproducibility for accessing variability during dissolution testing: A technical note AN - 21127473; 11176475 AB - Conclusions In this study, the gauge R&R method was used to analyze sources of variability for the paddle apparatus (USP apparatus 2). An initial evaluation of gauge R&R dissolution testing results using the amount dissolved at 30 minutes for a 10-mg prednisone tablet showed no instrument or operator contributions to variability but did highlight some vessel differences within an instrument. Based on this finding, a new mechanical calibration step was developed to improve the performance of the measurement system. JF - AAPS PharmSciTech AU - Gao, Zongming AU - Moore, Terry AU - Smith, Anjanette P AU - Doub, William AU - Westenberger, Benjamin AU - Buhse, Lucinda AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 63101 St Louis, MO, Zongming.Gao@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 11 EP - 15 PB - Springer New York LLC VL - 8 IS - 4 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Prednisone KW - Tablets KW - Dissolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21127473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Gauge+repeatability+and+reproducibility+for+accessing+variability+during+dissolution+testing%3A+A+technical+note&rft.au=Gao%2C+Zongming%3BMoore%2C+Terry%3BSmith%2C+Anjanette+P%3BDoub%2C+William%3BWestenberger%2C+Benjamin%3BBuhse%2C+Lucinda&rft.aulast=Gao&rft.aufirst=Zongming&rft.date=2007-10-01&rft.volume=8&rft.issue=4&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fpt0804082 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Prednisone; Tablets; Dissolution DO - http://dx.doi.org/10.1208/pt0804082 ER - TY - JOUR T1 - High prevalence of CTX-M-15 extended-spectrum {szligbeta}-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15 AN - 21122524; 7613404 JF - Journal of Antimicrobial Chemotherapy AU - Upton, Arlo AU - Mohiuddin, Jasmine AU - Bathgate, Tracy AU - Taylor, Susan AU - Simmons, Greg AU - Woodhouse, Rosemary AU - Heffernan, Helen AD - Clinical Microbiology, Lab Plus, Auckland City Hospital, Auckland, New Zealand. Population Protection Group, Auckland Regional Public Health Service, Auckland, New Zealand. Clinical Microbiology, Middlemore Hospital, Auckland, New Zealand. Antibiotic Reference Laboratory, Institute of Environmental Science and Research, Wellington, New Zealand Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 906 EP - 908 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 4 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Shigellosis KW - Shigella flexneri KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21122524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=High+prevalence+of+CTX-M-15+extended-spectrum+%7Bszligbeta%7D-lactamase+among+contacts+of+patients+with+shigellosis+due+to+Shigella+flexneri+carrying+CTX-M-15&rft.au=Upton%2C+Arlo%3BMohiuddin%2C+Jasmine%3BBathgate%2C+Tracy%3BTaylor%2C+Susan%3BSimmons%2C+Greg%3BWoodhouse%2C+Rosemary%3BHeffernan%2C+Helen&rft.aulast=Upton&rft.aufirst=Arlo&rft.date=2007-10-01&rft.volume=60&rft.issue=4&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Shigellosis; Shigella flexneri ER - TY - JOUR T1 - Clinical significance of the presence of amniotic fluid sludge in asymptomatic patients at high risk for spontaneous preterm delivery AN - 21065728; 8635431 AB - Objectives To determine the clinical significance of the presence of amniotic fluid (AF) sludge among asymptomatic patients at high risk for spontaneous preterm delivery. Methods This retrospective case-control study included 281 patients with (n = 66) or without (n = 215) AF sludge, who underwent transvaginal ultrasound examination between 13 and 29 completed weeks of gestation. Patients with threatened preterm labor, multiple gestation, fetal anomalies, placenta previa or uterine contractions were excluded. Results The prevalence of AF sludge in the study population was 23.5% (66/281). The rates of spontaneous preterm delivery at < 28 weeks, < 32 weeks, < 35 weeks and < 37 weeks of gestation were 14.7% (29/197), 21.3% (46/216), 28.7% (62/216) and 42.1% (91/216), respectively. Patients with sludge had: (1) a higher rate of spontaneous preterm delivery at < 28 weeks (46.5% (20/43) vs. 5.8% (9/154); P < 0.001), < 32 weeks (55.6% (25/45) vs. 12.3% (21/171); P < 0.001) and < 35 weeks (62.2% (28/45) vs. 19.9% (34/171); P < 0.001); (2) a higher frequency of clinical chorioamnionitis (15.2% (10/66) vs. 5.1% (11/215); P = 0.007), histologic chorioamnionitis (61.5% (40/65) vs. 28% (54/193); P < 0.001) and funisitis (32.3% (21/65) vs. 19.2% (37/193); P = 0.03); (3) a higher frequency of preterm prelabor rupture of membranes (PROM) (39.4% (26/66) vs. 13.5% (29/215); P < 0.001), lower gestational age at preterm PROM (median 24.7 (interquartile range (IQR), 22.3-28.1) weeks vs. 32.3 (IQR, 27.7-34.8) weeks; P < 0.001); and (4) shorter median ultrasound-to-delivery interval (sludge positive 127 days (95% CI, 120-134 days) vs. sludge negative 161 days (95% CI, 153-169 days); P < 0.001) and ultrasound-to-preterm PROM interval (sludge positive 23 days (95% CI, 7-39 days) vs. sludge negative 57 days (95% CI, 38-77 days); P = 0.003) than those without sludge. AF sludge was an independent explanatory variable for the occurrence of spontaneous preterm delivery at < 28 weeks, < 32 weeks and < 35 weeks, preterm PROM, microbial invasion of the amniotic cavity (MIAC) and histologic chorioamnionitis. Moreover, the combination of a cervical length < 25 mm and sludge conferred an odds ratio of 14.8 and 9.9 for spontaneous preterm delivery at < 28 weeks and < 32 weeks, respectively. Conclusions AF sludge is an independent risk factor for spontaneous preterm delivery, preterm PROM, MIAC and histologic chorioamnionitis in asymptomatic patients at high risk for spontaneous preterm delivery. Furthermore, the combination of sludge and a short cervix confers a higher risk for spontaneous preterm delivery at < 28 weeks and < 32 weeks than a short cervix alone. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Espinoza, J AU - Romero, R AU - Goncalves, L F AU - Nien, J K AU - Soto, E AU - Khalek, N AU - Camacho, N AU - Hendler, I AU - Mittal, P AU - Friel, L A AU - Gotsch, F AU - Erez, O AU - Than, N G AU - Mazaki-Tovi, S AU - Schoen, M L AU - Hassan, S S AD - Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA, nichdprbchiefstaff@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 706 EP - 714 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 5 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Cavities KW - Uterus KW - Gestational age KW - Gynecology KW - Sludges KW - Rupture KW - Population studies KW - Fetuses KW - Placenta KW - Risk factors KW - Chorioamnionitis KW - Cervix KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21065728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Clinical+significance+of+the+presence+of+amniotic+fluid+sludge+in+asymptomatic+patients+at+high+risk+for+spontaneous+preterm+delivery&rft.au=Kusanovic%2C+J+P%3BEspinoza%2C+J%3BRomero%2C+R%3BGoncalves%2C+L+F%3BNien%2C+J+K%3BSoto%2C+E%3BKhalek%2C+N%3BCamacho%2C+N%3BHendler%2C+I%3BMittal%2C+P%3BFriel%2C+L+A%3BGotsch%2C+F%3BErez%2C+O%3BThan%2C+N+G%3BMazaki-Tovi%2C+S%3BSchoen%2C+M+L%3BHassan%2C+S+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2007-10-01&rft.volume=30&rft.issue=5&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.4081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sludges; Risk factors; Chorioamnionitis; Ultrasound; Cervix; Amniotic fluid; Cavities; Gestational age; Placenta; Gynecology; Fetuses; Obstetrics; Population studies; Rupture; Uterus DO - http://dx.doi.org/10.1002/uog.4081 ER - TY - JOUR T1 - The Nanoparticle Information Library (NIL): A Prototype for Linking and Sharing Emerging Data AN - 21057097; 8502008 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Miller, Arthur L AU - Hoover, Mark D AU - Mitchell, David M AU - Stapleton, Brian P AD - National Institute for Occupational Safety and Health, Spokane, Washington Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - D131 EP - D134 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21057097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=The+Nanoparticle+Information+Library+%28NIL%29%3A+A+Prototype+for+Linking+and+Sharing+Emerging+Data&rft.au=Miller%2C+Arthur+L%3BHoover%2C+Mark+D%3BMitchell%2C+David+M%3BStapleton%2C+Brian+P&rft.aulast=Miller&rft.aufirst=Arthur&rft.date=2007-10-01&rft.volume=4&rft.issue=12&rft.spage=D131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701683947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15459620701683947 ER - TY - JOUR T1 - Uncertainty Determination for Nondestructive Chemical Analytical Methods Using Field Data and Application to XRF Analysis for Lead AN - 21053241; 8502015 AB - Air sampling and analytical methods are developed to provide a basis for decision making. They are evaluated in the laboratory against prescribed fitness-for-use criteria even though laboratory validation does not take into account all possible sources of uncertainty in field application. Field evaluation would be preferable but is complicated by the lack of controlled conditions, which limits the ability to compare analytical methods and to recognize outliers and assess variance homogeneity across the range of interest. The specific situation of evaluating nondestructive field analytical methods against their reference laboratory equivalent is considered here, since the difficulty of providing replicates is obviated in this case. A portable X-ray fluorescence (XRF) analyzer was used to determine the lead content of air filter samples from several workplaces where lead is used or is a contaminant of the process material. The portable XRF method has the advantage of allowing for faster decisions compared with the alternative of submitting the air samples to an off-site laboratory for analysis. Since the XRF method is nondestructive, the same air samples were also subjected to the reference laboratory-based method of analysis. Two statistical approaches were developed specifically to deal with non-normal elements of the data in evaluating the results. The ISO GUM method identifies outliers and then calculates an accuracy range about the true concentration for the remainder of the data. This coverage is then adjusted to account for the rate of outlier occurrence. The bootstrap procedure uses a large number of computer-generated data points that are sampled, with replacement, from the original set including outliers to determine the coverage. No significant difference is seen between the two statistical approaches. Both approaches result in similar coverage and support the adoption of method acceptance criteria specific to field evaluation (a symmetric accuracy range of 35%). The portable XRF analyzer met this criterion when used with several different sampling methods and thus could be used as a method for routine evaluation of compliance with lead limit values. As the method is nondestructive, further analysis of air samples with analytical results near decision points is possible. JF - Journal of Occupational and Environmental Hygiene AU - Bartley, David L AU - Slaven, James E AU - Rose, Mike C AU - Andrew, Michael E AU - Harper, Martin AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 931 EP - 942 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Pollutant removal KW - Fluorescence KW - Air purification KW - Compliance KW - Air sampling KW - Lead KW - Sampling methods KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21053241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Uncertainty+Determination+for+Nondestructive+Chemical+Analytical+Methods+Using+Field+Data+and+Application+to+XRF+Analysis+for+Lead&rft.au=Bartley%2C+David+L%3BSlaven%2C+James+E%3BRose%2C+Mike+C%3BAndrew%2C+Michael+E%3BHarper%2C+Martin&rft.aulast=Bartley&rft.aufirst=David&rft.date=2007-10-01&rft.volume=4&rft.issue=12&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701712712 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pollutant removal; Fluorescence; Air purification; Compliance; Air sampling; Sampling methods; Lead DO - http://dx.doi.org/10.1080/15459620701712712 ER - TY - RPRT T1 - A Hispanic Ironworker Dies When He Falls 50 Feet Through a Floor Opening AN - 20968649; 11069763 AB - A 24 year-old Hispanic ironworker died after falling through a floor opening on a building platform. The victim and two co-workers were evaluating a job they were to undertake at a later date when the incident occurred. The platform on which they were standing was approximately 50 feet above the ground. The hole through which the victim fell had a cover, but it was not secured in place. The cover did not have any marking on it to indicate what it was being used for. The victim was wearing fall protective equipment but was not tied off. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP) should: Ensure that proper procedures are followed when employees are working around elevated floor openings. JF - A Hispanic Ironworker Dies When He Falls 50 Feet Through a Floor Opening. [np]. 2007. AU - Anonymous Y1 - 2007/10// PY - 2007 DA - Oct 2007 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - prevention KW - Protective equipment KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20968649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Hispanic+Ironworker+Dies+When+He+Falls+50+Feet+Through+a+Floor+Opening&rft.title=A+Hispanic+Ironworker+Dies+When+He+Falls+50+Feet+Through+a+Floor+Opening&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - A Hispanic Maintenance Worker Dies after Falling Through a Skylight AN - 20968227; 11069762 AB - A 39-year-old Hispanic maintenance worker died from injuries received after a fail through a skylight. The victim was using a broom to clean the debris off the skylight. As the victim was applying pressure to the broom, the broom handle broke. The victim lost his balance and fell through the skylight cover and opening approximately 17 feet to the floor below. The employer of the victim had no written employee safety or training programs. The CA/FACE investigator determined that, in order to prevent future occurrences, employers should: Develop and implement safe procedures for cleaning skylights. Establish and maintain an injury and Illness Prevention Program (IIPP). JF - A Hispanic Maintenance Worker Dies after Falling Through a Skylight. [np]. 2007. AU - Anonymous Y1 - 2007/10// PY - 2007 DA - Oct 2007 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Training KW - prevention KW - Ethnic groups KW - Maintenance KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20968227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Hispanic+Maintenance+Worker+Dies+after+Falling+Through+a+Skylight&rft.title=A+Hispanic+Maintenance+Worker+Dies+after+Falling+Through+a+Skylight&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Identification of Phenolic Dermal Sensitizers in a Wound Closure Tape AN - 20884266; 8403967 AB - A latex-allergic patient presented with a severe local reaction to a non-latex wound closure bandage following surgery. Extracts of the bandage were analyzed by gas chromatograph-electron impact-mass spectrometry (GC EI-MS) in the total ion monitoring mode. Components were identified by their ion mass fingerprint and elution time as a corresponding standard from the GC column. The chemicals identified were 4,4'-thiobis-(6-tert-butyl-m-cresol) (TBBC), 6-tert-Butyl-m-cresol (BC), 2,4-di-tert-butylphenol (BP) and erucamide (EA). Sensitization potential of these chemicals was evaluated using two quantitative structure-activity relationship (QSAR) programs. The phenol 2,6-di-tert-butyl-4-(hydroxymethyl)phenol (BHP) was also included in the test series. It was initially thought to be present in the bandage but detectable levels could not be confirmed. The potential for TBBC to induce a sensitization response was predicted by both Derek for Windows and TOPKAT 6.2. The potential for BC and BP to induce a sensitization response was predicted by Derek for Windows, but not TOPKAT. BHP and EA were not predicted to be sensitizers by either QSAR program. Local lymph node assay (LLNA) analysis of the chemicals identified TBBC, BP, and BC as potential sensitizers with EC3 values between 0.2 and 4.5%. None of the animals exhibited body weight loss or skin irritation at the concentrations tested. In agreement with the toxicological modeling, BHP did not induce a sensitization response in the LLNA. Following a positive LLNA response, TBBC, BP, and BC were further characterized by phenotypic analysis of the draining lymph nodes. A positive LLNA result coupled with a lack of increase in B220+IgE+ cell and serum IgE characterize these chemicals as Type IV sensitizers. These studies used a multidisciplinary approach combining clinical observation, GC-EI-MS for chemical identification, QSAR modeling of chemicals prior to animal testing, and the LLNA for determination of the sensitization potential of chemicals in a manufactured product. JF - Journal of Immunotoxicology AU - Myers, L P AU - Law, B F AU - Fedorowicz, A AU - Siegel, P D AU - Butterworth, L F AU - Anderson, S E AU - Sussman, G AU - Shapiro, M AU - Meade, B J AU - Beezhold, D AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 303 EP - 310 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 4 SN - 1547-691X, 1547-691X KW - Toxicology Abstracts; Immunology Abstracts KW - X 24310:Pharmaceuticals KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20884266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Identification+of+Phenolic+Dermal+Sensitizers+in+a+Wound+Closure+Tape&rft.au=Myers%2C+L+P%3BLaw%2C+B+F%3BFedorowicz%2C+A%3BSiegel%2C+P+D%3BButterworth%2C+L+F%3BAnderson%2C+S+E%3BSussman%2C+G%3BShapiro%2C+M%3BMeade%2C+B+J%3BBeezhold%2C+D&rft.aulast=Myers&rft.aufirst=L&rft.date=2007-10-01&rft.volume=4&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910701680236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15476910701680236 ER - TY - JOUR T1 - Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite AN - 20837957; 7763418 AB - Arsenic is an environmental pollutant capable of causing oxidative stress, disturbance of metabolism, and cancer development. The present study was undertaken to investigate the effects of exposure to sodium arsenite on the glutathione pool, lipid peroxidation, protein carbonyl levels, global DNA methylation, and activities of six antioxidant enzymes in goldfish liver. In a preliminary experiment, 7-day exposure to 200 M sodium arsenite, but not 10 or 100 M, disturbed the glutathione status. A detailed investigation of oxidative stress development and antioxidant responses was further examined during different periods of exposure to 200 M sodium arsenite. This treatment increased lipid peroxide levels after 1 and 4 days of exposure but did not affect thiobarbituric acid reactive substances and protein carbonyls. Oxidized glutathione and the oxidative stress index rose after 4 days, but de novo glutathione synthesis decreased both parameters after 7 days. Activities of the main antioxidant enzymes-superoxide dismutase, catalase, and glutathione peroxidase, were elevated after longer periods of exposure, indicating an enhanced antioxidant response. Arsenite exposure led to DNA hypomethylation, which is an early marker of disturbed epigenetic regulations. The findings suggest that goldfish livers cope with arsenic-induced oxidative stress mainly through adaptive changes in the glutathione pool and antioxidant enzymes. JF - Environmental and Molecular Mutagenesis AU - Bagnyukova, Tetyana V AU - Luzhna, Lidia I AU - Pogribny, Igor P AU - Lushchak, Volodymyr I AD - Department of Biochemistry, Precarpathian National University, Ivano-Frankivsk, Ukraine, Tetyana.Bagnyukova@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 658 EP - 665 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 8 SN - 0893-6692, 0893-6692 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - thiobarbituric acid KW - Arsenic KW - Sodium arsenite KW - Antioxidants KW - Arsenite KW - Enzymes KW - Carassius auratus KW - Cancer KW - Catalase KW - Lipid peroxidation KW - Mutagenesis KW - Pollutants KW - epigenetics KW - Oxidative stress KW - Glutathione peroxidase KW - DNA methylation KW - Liver KW - peroxide KW - carbonyls KW - Metabolism KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20837957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Oxidative+stress+and+antioxidant+defenses+in+goldfish+liver+in+response+to+short-term+exposure+to+arsenite&rft.au=Bagnyukova%2C+Tetyana+V%3BLuzhna%2C+Lidia+I%3BPogribny%2C+Igor+P%3BLushchak%2C+Volodymyr+I&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2007-10-01&rft.volume=48&rft.issue=8&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - thiobarbituric acid; Arsenic; Antioxidants; Sodium arsenite; Arsenite; Enzymes; Lipid peroxidation; Catalase; Cancer; Mutagenesis; Pollutants; Glutathione peroxidase; Oxidative stress; epigenetics; Liver; DNA methylation; peroxide; carbonyls; Metabolism; Carassius auratus DO - http://dx.doi.org/10.1002/em.20328 ER - TY - JOUR T1 - 70-P: Immunological long-term evaluation of decellularized versus cryopreserved allografts during ROSS operation AN - 20764472; 8177885 JF - Human Immunology AU - Silva, HA AU - Glehn, CQC AU - Costa, FDA AU - Contini-Duarte, D Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 68 IS - 1 SN - 0198-8859, 0198-8859 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Transplantation KW - Allografts KW - Cryopreservation KW - W 30945:Fermentation & Cell Culture KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20764472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Human+Immunology&rft.atitle=70-P%3A+Immunological+long-term+evaluation+of+decellularized+versus+cryopreserved+allografts+during+ROSS+operation&rft.au=Silva%2C+HA%3BGlehn%2C+CQC%3BCosta%2C+FDA%3BContini-Duarte%2C+D&rft.aulast=Silva&rft.aufirst=HA&rft.date=2007-10-01&rft.volume=68&rft.issue=1&rft.spage=S50&rft.isbn=&rft.btitle=&rft.title=Human+Immunology&rft.issn=01988859&rft_id=info:doi/10.1016%2Fj.humimm.2007.08.093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - SuppNotes - 33rd Ann. ASHI Meeting Abstracts 2007. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transplantation; Allografts; Cryopreservation DO - http://dx.doi.org/10.1016/j.humimm.2007.08.093 ER - TY - JOUR T1 - Carbaryl exposure and incident cancer in the Agricultural Health Study AN - 20649762; 8079685 AB - Carbaryl is a carbamate insecticide with a broad spectrum of uses in agricultural, commercial and household settings. It has previously been linked with non-Hodgkin lymphoma (NHL) but studies of cancer risk in humans are limited. We examined occupational carbaryl use and risk of all cancers in the Agricultural Health Study, a prospective study of a cohort of pesticide applicators in North Carolina and Iowa. This analysis included 21,416 subjects (1,291 cases) enrolled from 1993-1997 and followed for cancer incidence through 2003. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Carbaryl was not associated with cancer risk overall. Relative to subjects who never used carbaryl, melanoma risk was elevated with >175 lifetime exposure-days (RR = 4.11; 95%CI, 1.33-12.75; p-trend = 0.07), >10 years of use (RR = 3.19; 95%CI, 1.28-7.92; p-trend = 0.04), or 10 days of use per year (RR = 5.50; 95%CI, 2.19-13.84; p-trend < 0.001). Risk remained after adjusting for sunlight exposure. Although not significant, there appeared to be a trend of decreasing prostate cancer risk with increasing level of exposure. A small increase in NHL risk was observed using some, but not all, exposure measures. No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution. JF - International Journal of Cancer AU - Mahajan, Rajeev AU - Blair, Aaron AU - Coble, Joseph AU - Lynch, Charles F AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, alavanjm@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1799 EP - 1805 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 8 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - USA, North Carolina KW - Inventories KW - Carbaryl KW - melanoma KW - sunlight KW - Pesticides (carbamates) KW - Cancer KW - Melanoma KW - households KW - Prostate cancer KW - Insecticides KW - USA, Iowa KW - Pesticides KW - Sunlight KW - prostate cancer KW - lymphoma KW - Lymphoma KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Carbaryl+exposure+and+incident+cancer+in+the+Agricultural+Health+Study&rft.au=Mahajan%2C+Rajeev%3BBlair%2C+Aaron%3BCoble%2C+Joseph%3BLynch%2C+Charles+F%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Mahajan&rft.aufirst=Rajeev&rft.date=2007-10-01&rft.volume=121&rft.issue=8&rft.spage=1799&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Insecticides; Prostate cancer; Pesticides; Sunlight; Carbaryl; Pesticides (carbamates); Lymphoma; Melanoma; households; melanoma; prostate cancer; sunlight; lymphoma; Cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1002/ijc.22836 ER - TY - JOUR T1 - Book review of Bhuyan, M., Measurement and Control in Food Processing (2007), CRC Press, Taylor & Francis Group, 340 pp. AN - 20637793; 7539104 JF - Food Microbiology AU - Schlesser, J Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 804 EP - 805 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 24 IS - 7-8 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Food processing KW - Books KW - Reviews KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Book+review+of+Bhuyan%2C+M.%2C+Measurement+and+Control+in+Food+Processing+%282007%29%2C+CRC+Press%2C+Taylor+%26amp%3B+Francis+Group%2C+340+pp.&rft.au=Schlesser%2C+J&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2007-10-01&rft.volume=24&rft.issue=7-8&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Food processing; Reviews; Books DO - http://dx.doi.org/10.1016/j.fm.2007.03.007 ER - TY - JOUR T1 - An Indoor Environmental Quality Investigation of the Fayette County (Pennsylvania) Courthouse AN - 20543819; 8105099 AB - The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation (HHE) investigation in the basement of the Fayette County Courthouse in Uniontown, Pennsylvania. Employees had reported a variety of health complaints including headaches, throat irritation, eye irritation, nausea, fatigue and nasal/sinus symptoms. Potential causes of the complaints included excessive mould/mildew, lack of air flow, odours and high dust levels. A number of locations showing signs of water incursion or leakage were found to have mould growth. The air flow provided by the ventilation systems in most areas was inadequate, although temperature, relative humidity and carbon dioxide levels largely met published recommendations. Levels of common volatile organic compounds were all below established exposure limits, and only toluene was found in concentrations above established odour thresholds. JF - Indoor and Built Environment AU - Martin, SB Jr AU - Coffey, C C AD - Department of Health & Human Services, Centers for Disease Control and Prevention, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, SMartin1@cdc.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 456 EP - 464 VL - 16 IS - 5 SN - 1420-326X, 1420-326X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts KW - Relative humidity KW - Odor thresholds KW - Pharynx KW - Eye KW - Ventilation KW - Toluene KW - Occupational safety KW - Threshold limits KW - Odors KW - fatigue KW - Dust KW - Air temperature KW - air flow KW - Headache KW - Mildew KW - Nausea KW - Air flow KW - Leakage KW - Fatigue KW - Temperature KW - Humidity KW - Sinus KW - Irritation KW - USA, Pennsylvania KW - volatile organic compounds KW - Environmental quality KW - Carbon dioxide KW - Volatile organic compounds KW - P 0000:AIR POLLUTION KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20543819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+and+Built+Environment&rft.atitle=An+Indoor+Environmental+Quality+Investigation+of+the+Fayette+County+%28Pennsylvania%29+Courthouse&rft.au=Martin%2C+SB+Jr%3BCoffey%2C+C+C&rft.aulast=Martin&rft.aufirst=SB&rft.date=2007-10-01&rft.volume=16&rft.issue=5&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Indoor+and+Built+Environment&rft.issn=1420326X&rft_id=info:doi/10.1177%2F1420326X07082791 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Relative humidity; Odor thresholds; Pharynx; Fatigue; Leakage; Ventilation; Eye; Toluene; Threshold limits; Sinus; Air temperature; Irritation; Dust; Headache; volatile organic compounds; Mildew; Environmental quality; Nausea; Carbon dioxide; Air flow; Occupational safety; Temperature; Humidity; Odors; fatigue; air flow; Volatile organic compounds; USA, Pennsylvania DO - http://dx.doi.org/10.1177/1420326X07082791 ER - TY - JOUR T1 - The Utility of a Rodent Model in Detecting Pediatric Drug-Induced Nephrotoxicity AN - 20363678; 7617564 AB - A multi-age rat model was used to identify potential age-related differences in renal injury following exposure to gentamicin (GM). In this study, 10-, 25-, 40-, and 80-day-old Sprague-Dawley rats were dosed with GM at 0, 50, or 100 mg kg super(-1) body weight per day (mkd) sc for 6 or 14 days. Urine samples were collected up to 72 h after initial dosing. The maximum tolerated dose was lower in 10-day-old rats than for other ages (none survived 11 days of treatment). Eighty-day-old rats given the highest dose showed a diminished rate of growth and an increase in serum creatinine, blood urea nitrogen (BUN), urinary kidney injury molecule-1 (Kim-1), and renal pathology. Ten- and 40-day-old rats given 100 mkd of GM for 6- or 14 days also had increased levels of serum BUN and Cr and renal pathology, whereas only mild renal alterations were found in 25-day-old rats. After 6 days of treatment with 100 mkd GM, significant increases in Havcr-1 (Kim-1) gene expression were detected only in 10- and 80-day-old rats. In urine samples, nuclear magnetic resonance and ultra performance liquid chromatography/mass spectrometry analysis detected changes related to GM efficacy (e.g., hippurate) and increases in metabolites related to antioxidant activity, which was greatest in the 80-day-old rats. The magnitude of the genomic, metabonomic, and serum chemistry changes appeared to correlate with the degree of nephropathy. These findings indicate that an experimental animal model that includes several developmental stages can detect age-related differences in drug-induced organ toxicities and may be a useful predictor of pediatric drug safety in preclinical studies. JF - Toxicological Sciences AU - Espandiari, Parvaneh AU - Zhang, Jun AU - Rosenzweig, Barry A AU - Vaidya, Vishal S AU - Sun, Jinchun AU - Schnackenberg, Laura AU - Herman, Eugene H AU - Knapton, Alan AU - Bonventre, Joseph V AU - Beger, Richard D AU - Thompson, Karol L AU - Hanig, Joseph AD - Center for Drug Evaluation and Research, Silver Spring, Maryland 20993. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115. National Center for Toxicological Research, Jefferson, Arkansas 72079 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 637 EP - 648 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 2 SN - 1096-6080, 1096-6080 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Age KW - Antioxidants KW - Pathology KW - Injuries KW - Animal models KW - Mass spectrometry KW - Metabolites KW - Urea KW - renal KW - Mass spectroscopy KW - Rats KW - Gene expression KW - Body weight KW - Nephropathy KW - N.M.R. KW - genomics KW - body weight KW - Drugs KW - Pediatrics KW - Developmental stages KW - Toxicity KW - Gentamicin KW - Blood KW - Creatinine KW - Liquid chromatography KW - Urine KW - Kidney KW - rodents KW - Nitrogen KW - X 24310:Pharmaceuticals KW - H 14000:Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20363678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=The+Utility+of+a+Rodent+Model+in+Detecting+Pediatric+Drug-Induced+Nephrotoxicity&rft.au=Espandiari%2C+Parvaneh%3BZhang%2C+Jun%3BRosenzweig%2C+Barry+A%3BVaidya%2C+Vishal+S%3BSun%2C+Jinchun%3BSchnackenberg%2C+Laura%3BHerman%2C+Eugene+H%3BKnapton%2C+Alan%3BBonventre%2C+Joseph+V%3BBeger%2C+Richard+D%3BThompson%2C+Karol+L%3BHanig%2C+Joseph&rft.aulast=Espandiari&rft.aufirst=Parvaneh&rft.date=2007-10-01&rft.volume=99&rft.issue=2&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Antioxidants; Injuries; Pediatrics; Animal models; Developmental stages; Urea; Metabolites; Toxicity; Mass spectroscopy; Gentamicin; Gene expression; Blood; Creatinine; Body weight; Urine; Liquid chromatography; Nephropathy; Kidney; N.M.R.; genomics; Drugs; Nitrogen; Pathology; Mass spectrometry; renal; Rats; body weight; rodents ER - TY - JOUR T1 - Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea AN - 20331722; 7613390 AB - OBJECTIVES: To investigate the prevalence of qnr determinants, their influence on quinolone susceptibility and their association with other plasmid-mediated genes in AmpC-producing Enterobacteriaceae without any selection criteria. METHODS: A total of 644 consecutive, non-duplicate isolates of Enterobacter cloacae (186), Enterobacter aerogenes (154), Citrobacter freundii (138) and Serratia marcescens (166) were examined. We performed antimicrobial susceptibility testing and PCR for qnr determinants (qnrA, qnrB and qnrS), extended-spectrum {szligbeta}-lactamase (ESBL) (bla sub(TEM), bla sub(SHV) and bla sub(CTX-M)), orf513, orf1005 and bla sub(DHA-1.) To differentiate qnr subtypes, restriction enzyme analysis and sequencing was performed. RESULTS: The prevalence of qnr determinants was high in C. freundii (38.4%) and E. cloacae (28.5%), but low in E. aerogenes (3.2%) and S. marcescens (2.4%). qnrA1 was most frequent in E. cloacae, and qnrB was prevalent in C. freundii. All the qnrA- and qnrB4-positive isolates showed ciprofloxacin MICs greater than or equal to 0.5 mg/L and nalidixic acid MICs greater than or equal to 16 mg/L. However, the B1 and B2 subtypes showed a wide range of quinolone MICs. In relation to ESBLs, we found that qnrA1, qnrB2 and qnrB4 producers were significantly more frequent among ESBL producers (P < 0.05). Twelve of 13 qnrB4 producers harboured bla sub(DHA-1). orf513 was detected in 43 isolates of the 47 isolates with co-resident qnr and ESBL genes. None of the qnr producers harboured orf1005. CONCLUSIONS: The prevalence of qnrA and qnrB was high among C. freundii and E. cloacae in Korea and there were characteristics unique to the qnr subtypes. Quinolones should be used cautiously in these species, especially when they are ESBL producers. JF - Journal of Antimicrobial Chemotherapy AU - Park, Yeon-Joon AU - Yu, Jin Kyung AU - Lee, Seungok AU - Oh, Eun-Jee AU - Woo, Gun-Jo AD - Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital, 505 Banpo-dong, Seocho-ku, Seoul 137-701, Korea. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Holy Family Hospital, Sosa-dong, Wonmi-gu, Bucheon, Kyunggi-do 420-717, Korea. Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-gu, Seoul 122-704, Korea Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 868 EP - 871 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 4 SN - 0305-7453, 0305-7453 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Citrobacter freundii KW - Quinolones KW - Enzymes KW - Genetic diversity KW - Enterobacter aerogenes KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Ciprofloxacin KW - Enterobacter cloacae KW - Nalidixic acid KW - Serratia marcescens KW - Polymerase chain reaction KW - Enterobacteriaceae KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20331722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Prevalence+and+diversity+of+qnr+alleles+in+AmpC-producing+Enterobacter+cloacae%2C+Enterobacter+aerogenes%2C+Citrobacter+freundii+and+Serratia+marcescens%3A+a+multicentre+study+from+Korea&rft.au=Park%2C+Yeon-Joon%3BYu%2C+Jin+Kyung%3BLee%2C+Seungok%3BOh%2C+Eun-Jee%3BWoo%2C+Gun-Jo&rft.aulast=Park&rft.aufirst=Yeon-Joon&rft.date=2007-10-01&rft.volume=60&rft.issue=4&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ciprofloxacin; Quinolones; Nalidixic acid; Genetic diversity; Enzymes; Polymerase chain reaction; Minimum inhibitory concentration; Antimicrobial agents; Enterobacter cloacae; Citrobacter freundii; Serratia marcescens; Enterobacter aerogenes; Enterobacteriaceae ER - TY - JOUR T1 - Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells AN - 20318566; 7610207 AB - Nuclear factor of activated T cell (NFAT)-3 is a member of the transcription factor NFAT family, which has been demonstrated to be responsible for the up-regulation of the pro-inflammatory cytokine tumor necrosis factor (TNF) in the immune system. Our most recent studies have also shown that TNF is able to induce cell transformation in mouse epidermal Cl41 cells by induction of cyclooxygenase-2 (COX-2) expression. To provide direct evidence for NFAT3 in the environmental carcinogen-caused carcinogenic effect, ( plus or minus )-benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), an ultimate environmental carcinogen metabolized from benzo[a]pyrene, was utilized. We found that exposure of Cl41 cells to B[a]PDE was able to induce cell transformation in Cl41 cells, while specific knock-down of NFAT3 resulted in the dramatic inhibition of this cell transformation. The tumorigenicity of B[a]PDE-caused transformed cells was confirmed in nude mice, whereas the tumor formation of B[a]PDE-treated NFAT3 small interference RNA (siRNA) knock-down cells was significantly reduced. Further studies showed that the role of NFAT3 in B[a]PDE-caused cell transformation was mediated by up-regulation of its downstream targeted gene TNF. This conclusion was based on the findings that inhibition of NFAT3 activation by either FK506 or NFAT3 siRNA dramatically down-regulated the TNF induction upon B[a]PDE exposure, and that knock-down of TNF by its specific siRNA also led to abrogation of B[a]PDE-induced cell transformation in Cl41 cells and their tumorigenicity in nude mice. Collectively, these results provide direct evidence for the important role of NFAT3 activation in B[a]PDE-induced cell transformation by up-regulation of TNF expression in mouse epidermal Cl41 cells, further suggesting that B[a]PDE may exert its tumor promotion effect on skin carcinogenesis, at least partially, by inducing TNF expression. JF - Carcinogenesis AU - Ouyang, Weiming AU - Hu, Yu AU - Li, Jingxia AU - Ding, Min AU - Lu, Yongju AU - Zhang, Dongyun AU - Yan, Yan AU - Song, Lun AU - Qu, Qingshan AU - Desai, Dhimant AU - Amin, Shantu AU - Huang, Chuanshu AD - Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA. Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Department of Pharmacology, School of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2218 EP - 2226 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 10 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Cyclooxygenase-2 KW - Transformation KW - Skin KW - Tumor necrosis factor KW - Immune system KW - Tumorigenesis KW - Transformed cells KW - Tumorigenicity KW - Carcinogens KW - Tacrolimus KW - Cell activation KW - Inflammation KW - siRNA KW - Transcription factors KW - Carcinogenesis KW - RNA-mediated interference KW - Cytokines KW - Benzo(a)pyrene KW - NF-AT protein KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20318566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Direct+evidence+for+the+critical+role+of+NFAT3+in+benzo%5Ba%5Dpyrene+diol-epoxide-induced+cell+transformation+through+mediation+of+inflammatory+cytokine+TNF+induction+in+mouse+epidermal+Cl41+cells&rft.au=Ouyang%2C+Weiming%3BHu%2C+Yu%3BLi%2C+Jingxia%3BDing%2C+Min%3BLu%2C+Yongju%3BZhang%2C+Dongyun%3BYan%2C+Yan%3BSong%2C+Lun%3BQu%2C+Qingshan%3BDesai%2C+Dhimant%3BAmin%2C+Shantu%3BHuang%2C+Chuanshu&rft.aulast=Ouyang&rft.aufirst=Weiming&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=2218&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Cyclooxygenase-2; Skin; Immune system; Tumor necrosis factor; Transformed cells; Tumorigenesis; Tumorigenicity; Tacrolimus; Carcinogens; Inflammation; Cell activation; siRNA; Transcription factors; Carcinogenesis; Cytokines; RNA-mediated interference; Benzo(a)pyrene; NF-AT protein ER - TY - JOUR T1 - A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis AN - 20312457; 7617498 AB - Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection. JF - Thorax AU - Steingart, Karen R AU - Henry, Megan AU - Laal, Suman AU - Hopewell, Philip C AU - Ramsay, Andrew AU - Menzies, Dick AU - Cunningham, Jane AU - Weldingh, Karin AU - Pai, Madhukar AD - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA. County of Sacramento Department of Health and Human Services, Sacramento, California, USA. Veterans Affairs Medical Center and Departments of Pathology and Microbiology, New York University School of Medicine, New York, USA. UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland. Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada. Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen S, Denmark Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 911 EP - 918 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 62 IS - 10 SN - 0040-6376, 0040-6376 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Human immunodeficiency virus KW - Immunoglobulin G KW - Tuberculosis KW - Infection KW - Children KW - Lymph nodes KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20312457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=A+systematic+review+of+commercial+serological+antibody+detection+tests+for+the+diagnosis+of+extrapulmonary+tuberculosis&rft.au=Steingart%2C+Karen+R%3BHenry%2C+Megan%3BLaal%2C+Suman%3BHopewell%2C+Philip+C%3BRamsay%2C+Andrew%3BMenzies%2C+Dick%3BCunningham%2C+Jane%3BWeldingh%2C+Karin%3BPai%2C+Madhukar&rft.aulast=Steingart&rft.aufirst=Karen&rft.date=2007-10-01&rft.volume=62&rft.issue=10&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoglobulin G; Tuberculosis; Children; Infection; Lymph nodes; Human immunodeficiency virus ER - TY - JOUR T1 - Limits of longitudinal decline for the interpretation of annual changes in FEV sub(1) in individuals AN - 20309371; 7616406 AB - OBJECTIVE: Spirometry-based screening programmes often conduct annual assessment of longitudinal changes in forced expiratory volume in 1 second (FEV sub(1)) to identify individuals with excessive rates of decline. Both the American Thoracic Society (ATS) and the American College of Occupational and Environmental Medicine (ACOEM) recommend a reference limit value of greater than or equal to 15% for excessive annual decline. Neither the ATS nor the ACOEM adjust this limit for the precision of the existing spirometry data. The authors propose an improved method of defining the reference limit of longitudinal annual FEV sub(1) decline (LLD) based on the precision of the spirometry data. METHOD: The authors used data from four monitoring programmes and measured their data precision using a pair-wise within-person variation statistic. They then derived programme- and gender-specific absolute and relative LLD values and validated these against the 95th percentiles for observed yearly changes in FEV sub(1). RESULTS: The relative limit for annual decline was more practical than the absolute limit as it adjusted for gender differences in the magnitude of FEV sub(1). The programme-specific relative limit values were in good agreement with 95th percentiles for year-to-year FEV sub(1) changes and ranged from 6.6% to 15.8%. For individuals with COPD and bronchial hyperreactivity the 95th percentiles for year-to-year changes were about 15% and higher. CONCLUSIONS: The relative longitudinal limit for annual FEV sub(1) decline based upon precision of measurements is valid and can be generalised to different gender and population groups. A relative limit of approximately 10% appears appropriate for good quality workplace monitoring programmes, whereas a limit of about 15% appears appropriate for clinical evaluation of individuals with an obstructive airway disease. Computer software based on the method described is available from the corresponding author. JF - Occupational and Environmental Medicine AU - Hnizdo, Eva AU - Sircar, Kanta AU - Yan, Tieliang AU - Harber, Philip AU - Fleming, James AU - Glindmeyer, Henry W AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA Constella Group, Morgantown, WV, USA Division of Occupational and Environmental Medicine, Department of Family Medicine, University of California Los Angeles, Los Angeles, CA, USA Phoenix Fire Department, Phoenix, AZ, USA Section of Pulmonary, Critical Care, and Environmental Medicine, Department of Medicine, Tulane Medical School, New Orleans, LA, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 701 EP - 707 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 64 IS - 10 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Computer programs KW - Gender KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20309371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Limits+of+longitudinal+decline+for+the+interpretation+of+annual+changes+in+FEV+sub%281%29+in+individuals&rft.au=Hnizdo%2C+Eva%3BSircar%2C+Kanta%3BYan%2C+Tieliang%3BHarber%2C+Philip%3BFleming%2C+James%3BGlindmeyer%2C+Henry+W&rft.aulast=Hnizdo&rft.aufirst=Eva&rft.date=2007-10-01&rft.volume=64&rft.issue=10&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; Gender; Occupational exposure; Occupational health ER - TY - JOUR T1 - Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures AN - 20250018; 7785784 AB - Human alpha-1-proteinase inhibitor ( alpha sub(1)-PI) is the most abundant serine protease inhibitor in plasma. Its major function is inhibition of neutrophil elastase in lungs. alpha sub(1)-PI deficiency may result in severe, ultimately fatal emphysema. Three plasma-derived (pd-) alpha sub(1)-PI products are licensed in the US for replacement therapy of deficient patients. The recombinant versions (r- alpha sub(1)-PI), proposed as alternatives to pd- alpha sub(1)-PI products, have been under intensive investigation. For accurate determination of alpha sub(1)-PI from different sources and in various forms, there is an obvious need for reliable standardized assays for alpha sub(1)-PI quantification and potency measurements. As a part of our multi-step research focused on alpha sub(1)-PI structure-function investigation, we have established a simple and reproducible double-sandwich ELISA based on commercially available polyclonal antibodies. The developed ELISA allows the quantification of both pd- alpha sub(1)-PI and r- alpha sub(1)-PI in various complex matrices. A validation of the ELISA was performed with the working range of the assay (3.1-50ng/ml) established on the bases of the following parameters: linearity (3-100ng/ml, r super(2)=0.995); accuracy (87.3-114.6% recovery); intra-assay precision (%CV, 2.8%); inter-assay plate-to-plate precision (3.9% per day and 4.1% day-to-day); detection limit (1.10ng/ml); and quantification limit (3.34ng/ml). The analytical performance of the alpha sub(1)-PI ELISA indicates that this assay can be used for monitoring concentration levels of alpha sub(1)-PI in multi-component biological matrices, based on the following: (a) quantification of r- alpha sub(1)-PI in various fermentation mixtures (E. coli and A. niger); (b) investigation of alpha sub(1)-PI enzymatically digested in the conditions of harsh fungal proteolysis; (c) evaluation of thermally polymerized alpha sub(1)-PI; (d) quantification of alpha sub(1)-PI in human serum; and (e) comparative quantification of alpha sub(1)-PI in commercially available products. JF - Biologicals AU - Karnaukhova, E AU - Golding, B AU - Ophir, Y AD - Center for Biologics Evaluation and Research, United States Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA, elena.karnaukhova@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 285 EP - 295 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 35 IS - 4 SN - 1045-1056, 1045-1056 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Proteolysis KW - Emphysema KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Serine proteinase KW - Fermentation KW - Lung KW - Elastase KW - Escherichia coli KW - Leukocytes (neutrophilic) KW - K 03300:Methods KW - F 06900:Methods KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20250018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Development+and+evaluation+of+an+ELISA+for+quantification+of+human+alpha-1-proteinase+inhibitor+in+complex+biological+mixtures&rft.au=Karnaukhova%2C+E%3BGolding%2C+B%3BOphir%2C+Y&rft.aulast=Karnaukhova&rft.aufirst=E&rft.date=2007-10-01&rft.volume=35&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/10.1016%2Fj.biologicals.2006.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Emphysema; Antibodies; Enzyme-linked immunosorbent assay; Serine proteinase; Lung; Fermentation; Elastase; Leukocytes (neutrophilic); Escherichia coli DO - http://dx.doi.org/10.1016/j.biologicals.2006.11.002 ER - TY - JOUR T1 - Optimising piperacillin/tazobactam dosing in paediatrics AN - 20200457; 7584876 AB - Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this analysis is to describe the basis for the dosing recommendations in this age group. Pharmacokinetic (PK) parameters and demographic covariates from 53 children enrolled in two paediatric studies were used in the analysis. Individual drug clearance (CL) values calculated by non-compartmental methods were available. The influence of demographic covariates on CL was investigated by non-linear regression. The analysis identified CL to be dependent on body weight. CL was also found to be influenced by age in paediatric patients =9 months, a dose of 100/12.5mg/kg every 8h showed exposures similar to adults; for paediatric patients aged 2-9 months, the dose of 100/12.5mg/kg should be reduced by a factor of 0.8 (i.e. 80/10mg/kg), likely due to immature renal function. Based upon this analysis, dosing recommendations for paediatric patients down to 2 months of age were incorporated in the labelling. No data were available to allow additional recommendations for paediatric patients <2 months of age to be made. JF - International Journal of Antimicrobial Agents AU - Tornoe, Christoffer W AU - Tworzyanski, Jeffrey J AU - Imoisili, Menfo A AU - Alexander, John J AU - Korth-Bradley, Joan M AU - Gobburu, Jogarao V S AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, christoffer.tornoe@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 320 EP - 324 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 30 IS - 4 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology KW - Paediatric dosing KW - Anti-infectives KW - Pharmacometric analysis KW - Age KW - Intravenous administration KW - Data processing KW - Pediatrics KW - Tazobactam KW - Children KW - Pharmacokinetics KW - Demography KW - Renal function KW - Body weight KW - Piperacillin KW - Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20200457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Optimising+piperacillin%2Ftazobactam+dosing+in+paediatrics&rft.au=Tornoe%2C+Christoffer+W%3BTworzyanski%2C+Jeffrey+J%3BImoisili%2C+Menfo+A%3BAlexander%2C+John+J%3BKorth-Bradley%2C+Joan+M%3BGobburu%2C+Jogarao+V+S&rft.aulast=Tornoe&rft.aufirst=Christoffer&rft.date=2007-10-01&rft.volume=30&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2007.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; Intravenous administration; Age; Data processing; Body weight; Renal function; Pediatrics; Piperacillin; Tazobactam; Children; Drugs; Pharmacokinetics DO - http://dx.doi.org/10.1016/j.ijantimicag.2007.05.014 ER - TY - JOUR T1 - Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study AN - 20166841; 7617491 AB - BACKGROUND: Traffic exposure is a major contributor to ambient air pollution for people living close to busy roads. The relationship between traffic exposure and lung function remains inconclusive in adults. METHODS: A cross-sectional study was conducted to investigate the association between traffic exposure and lung function in the Atherosclerosis Risk in Communities (ARIC) study, a community based cohort of 15 792 middle aged men and women. Traffic density and distance to major roads were used as measures of traffic exposure. RESULTS: After controlling for potential confounders including demographic factors, personal and neighbourhood level socioeconomic characteristics, cigarette smoking and background air pollution, higher traffic density was significantly associated with lower forced expiratory volume in 1 s (FEV sub(1)) and forced vital capacity (FVC) in women. Relative to the lowest quartile of traffic density, the adjusted differences across increasing quartiles were 5.1, -15.4 and -21.5 ml for FEV sub(1) (p value of linear trend across the quartiles = 0.041) and 1.2, -23.4 and -34.8 ml for FVC (p trend = 0.010). Using distance from major roads as a simpler index of traffic related air pollution exposure, the FEV sub(1) was -15.7 ml (95% CI -34.4 to 2.9) lower and the FVC was -24.2 ml (95% CI -46.2 to -2.3) lower for women living within 150 m compared with subjects living further away. There was no significant effect of traffic density or distance to major roads on lung function in men. The FEV sub(1)/FVC ratio was not significantly associated with traffic exposure in either men or women. CONCLUSIONS: This is the largest published study of traffic exposure and pulmonary function in adults to date. These results add to growing evidence that chronic exposure to traffic related air pollution may adversely affect respiratory health. JF - Thorax AU - Kan, Haidong AU - Heiss, Gerardo AU - Rose, Kathryn M AU - Whitsel, Eric AU - Lurmann, Fred AU - London, Stephanie J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, North Carolina, USA. Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA. Sonoma Technology Inc, Petaluma, California, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 873 EP - 879 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 62 IS - 10 SN - 0040-6376, 0040-6376 KW - Pollution Abstracts; Toxicology Abstracts KW - demography KW - Socioeconomics KW - Arteriosclerosis KW - community involvement KW - Traffic KW - Air pollution KW - Demography KW - Socio-economic aspects KW - traffic KW - Lung KW - Chronic exposure KW - Cigarette smoking KW - Respiratory function KW - P 0000:AIR POLLUTION KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20166841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Traffic+exposure+and+lung+function+in+adults%3A+the+Atherosclerosis+Risk+in+Communities+study&rft.au=Kan%2C+Haidong%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BWhitsel%2C+Eric%3BLurmann%2C+Fred%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2007-10-01&rft.volume=62&rft.issue=10&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Demography; Air pollution; Socio-economic aspects; Chronic exposure; Lung; Cigarette smoking; Arteriosclerosis; Traffic; demography; traffic; Socioeconomics; Respiratory function; community involvement ER - TY - JOUR T1 - Interleukin-4 Cytotoxin Therapy Synergizes with Gemcitabine in a Mouse Model of Pancreatic Ductal Adenocarcinoma AN - 19896184; 7930223 AB - Targeting cell surface receptors with cytotoxins or immunotoxins provides a unique opportunity for tumor therapy. Here, we show the efficacy of the combination therapy of gemcitabine with an interleukin-4 (IL-4) cytotoxin composed of IL-4 and truncated Pseudomonas exotoxin in animal models of pancreatic ductal adenocarcinoma (PDA). We have observed that 42 of 70 (60%) tumor samples from patients with PDA express moderate- to high-density surface IL-4 receptor (IL-4R), whereas normal pancreatic samples express no or low-density IL-4R. IL-4 cytotoxin was specifically and highly cytotoxic [50% protein synthesis inhibition (IC sub(50)) ranging from >0.1 to 13 ng/mL] to six of eight pancreatic cancer cell lines, whereas no cytotoxicity (IC sub(50) >1,000 ng/mL) was observed in normal human pancreatic duct epithelium cells, fibroblasts, and human umbilical vein endothelial cells (HUVEC). We also showed that IL-4 cytotoxin in combination with gemcitabine exhibited synergistic antitumor activity in vitro. To confirm synergistic antitumor activity in vivo and monitor precise real-time disease progression, we used a novel metastatic and orthotopic mouse model using green fluorescent protein-transfected cancer cells and whole-body imaging system. The combination of both agents caused complete eradication of tumors in 40% of nude mice with small established PDA tumors. In addition, combined treatment significantly prolonged the survival of nude mice bearing day 14 advanced distant metastatic PDA tumors. Similar results were observed in mice xenografted with PDA obtained from a patient undergoing surgical resection. These results indicate that IL-4 cytotoxin combined with gemcitabine may provide effective therapy for the treatment of patients with PDA. [Cancer Res 2007; 67(20):9903-12] JF - Cancer Research AU - Shimamura, Takeshi AU - Royal, Richard E AU - Kioi, Mitomu AU - Nakajima, Atsushi AU - Husain, Syed R AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 9903 EP - 9912 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 20 SN - 0008-5472, 0008-5472 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Interleukin 4 KW - Synergism KW - Protein biosynthesis KW - Cytotoxins KW - Animal models KW - Pancreatic cancer KW - Pseudomonas KW - Tumors KW - umbilical vein KW - imaging KW - Immunotoxins KW - Exotoxins KW - Fibroblasts KW - Endothelial cells KW - Metastases KW - Cytotoxicity KW - Tumor cell lines KW - gemcitabine KW - Epithelium KW - Adenocarcinoma KW - Antitumor activity KW - J 02410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Interleukin-4+Cytotoxin+Therapy+Synergizes+with+Gemcitabine+in+a+Mouse+Model+of+Pancreatic+Ductal+Adenocarcinoma&rft.au=Shimamura%2C+Takeshi%3BRoyal%2C+Richard+E%3BKioi%2C+Mitomu%3BNakajima%2C+Atsushi%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2007-10-01&rft.volume=67&rft.issue=20&rft.spage=9903&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Interleukin 4; Protein biosynthesis; Synergism; Cytotoxins; Pancreatic cancer; Animal models; Tumors; umbilical vein; imaging; Exotoxins; Immunotoxins; Fibroblasts; Metastases; Endothelial cells; Tumor cell lines; Cytotoxicity; Epithelium; gemcitabine; Adenocarcinoma; Antitumor activity; Pseudomonas ER - TY - JOUR T1 - Two Cases of Uveal Amelanotic Melanoma in Transgenic Tyr-HRAS+ Ink4a/Arf Heterozygous Mice AN - 19884450; 7692106 AB - Uveal melanoma (UM) is uncommon among wild type mice. Efforts to develop transgenic mice to study this disease have resulted in pigmented tumors derived from the retinal pigment epithelium (RPE) or mixed tumors of RPE and UM complicating the study of UM specifically. Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice. These tumors were morphologically and immunohistochemically similar to spontaneous UM recently reported in the Ink4a/Arf homozygous (CKDN2A knockout) parent strain. The tumors originated in the posterior uveal tract. The neoplasms were comprised of bundles of spindle-shaped melanocytes admixed with some epithelioid cells. Tumors were immunohistochemically positive for neuron-specific enolase, S-100, pan-ras, but negative for cytokeratin and Melan-A. The development of early lenticular opacity and bilateral cataracts is a consistent phenotype of transgenic mice in which the retinoblastoma signaling pathway has been disrupted. Lenticular opacity and cataracts are rarely observed clinically in Tyr-HRAS+ Ink4a/Arf heterozygotes, rendering this strain suitable for ophthalmoscopy. Consequently, Tyr-HRAS+ Ink4a/Arf heterozygotes provide practical advantages, compared to the cataract-prone CKDN2A knockout strains, for real-time ophthalomoscopic detection and monitoring of UM while developing chemotherapeutic regimens and other research to understand the biology of UM. JF - Toxicologic Pathology AU - Latendresse, John R AU - Muskhelishvili, Levan AU - Warbritton, Alan AU - Tolleson, William H AD - Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, Arkansas, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 825 EP - 830 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 35 IS - 6 SN - 0192-6233, 0192-6233 KW - Biotechnology and Bioengineering Abstracts KW - cyclin-dependent kinase inhibitors KW - Cataracts KW - Melanocytes KW - Tumors KW - Transgenic mice KW - retinoblastoma KW - Melanoma KW - retinal pigment epithelium KW - Heterozygotes KW - Phosphopyruvate hydratase KW - Signal transduction KW - Cytokeratin KW - INK4 protein KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19884450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Two+Cases+of+Uveal+Amelanotic+Melanoma+in+Transgenic+Tyr-HRAS%2B+Ink4a%2FArf+Heterozygous+Mice&rft.au=Latendresse%2C+John+R%3BMuskhelishvili%2C+Levan%3BWarbritton%2C+Alan%3BTolleson%2C+William+H&rft.aulast=Latendresse&rft.aufirst=John&rft.date=2007-10-01&rft.volume=35&rft.issue=6&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701584221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - cyclin-dependent kinase inhibitors; Cataracts; Tumors; Melanocytes; Transgenic mice; Melanoma; retinoblastoma; retinal pigment epithelium; Heterozygotes; Phosphopyruvate hydratase; INK4 protein; Cytokeratin; Signal transduction DO - http://dx.doi.org/10.1080/01926230701584221 ER - TY - JOUR T1 - On the use of the T-RExTM tetracycline-inducible gene expression system in vivo AN - 19872604; 7586557 AB - Components of the commercially available T-RExTM system were used to create two types of transgenic mice. The first contained the tetracycline-repressor transgene under the control of the CMV promoter/enhancer; the second type contained a green fluorescent protein (GFP) reporter transgene under the control of the CMV promoter/enhancer with a tetracycline repressor operator sequence. Transgene expression was unpredictable in animals containing the individual transgenes. Animals with the reporter transgene expressed GFP in only some tissues (e.g., pancreas, kidney), and one line of reporter transgenic animals developed kidney disease, presumably due to expression of the transgene. The two types of transgenic animals were crossbred to produce double-transgenic animals with the object of regulating the expression of the reporter in vivo. When a similar double-transgenic system was constructed in cultured cells, the repressor protein suppressed the transcription of the reporter transgene. The presence of the repressor in double-transgenic animals had no effect on the expression of the reporter; double transgenic animals developed the same kidney disease that was seen in singly transgenic mice with the reporter. Our results indicate that transgenes under the control of the CMV promoter in the T-REx system express somewhat unpredictably and in only a limited number of tissues, making the use of this system for the development of in vivo models problematical. Biotechnol. Bioeng. 2007; 98:719-723. JF - Biotechnology and Bioengineering AU - Dobrovolsky, Vasily N AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, HFT-120, Jefferson, Arkansas 72079, vasily.dobrovolsky@fda.hhs.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 719 EP - 723 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 98 IS - 3 SN - 0006-3592, 0006-3592 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Pancreas KW - Kidney diseases KW - Animal models KW - Green fluorescent protein KW - Transcription KW - Transgenic mice KW - Tetracyclines KW - Cytomegalovirus KW - Gene expression KW - Operators KW - Promoters KW - Enhancers KW - Repressors KW - G 07730:Development & Cell Cycle KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19872604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=On+the+use+of+the+T-RExTM+tetracycline-inducible+gene+expression+system+in+vivo&rft.au=Dobrovolsky%2C+Vasily+N%3BHeflich%2C+Robert+H&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2007-10-01&rft.volume=98&rft.issue=3&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.21454 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Operators; Gene expression; Enhancers; Promoters; Pancreas; Green fluorescent protein; Animal models; Kidney diseases; Transcription; Tetracyclines; Transgenic mice; Repressors; Cytomegalovirus DO - http://dx.doi.org/10.1002/bit.21454 ER - TY - JOUR T1 - Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer AN - 19790572; 7930188 AB - Polymorphisms in the human genome contribute to wide variations in how individuals respond to medications, either by changing the pharmacokinetics of drugs or by altering the cellular response to therapeutic agents. The goal of the emerging discipline of pharmacogenomics is to personalize therapy based on an individual's genotype. Due to the relatively large frequency of single-nucleotide polymorphisms (SNP) in the human genome, synonymous SNPs are often disregarded in many pharmacogenomic studies based on the assumption that these are silent. We have shown recently that synonymous SNPs in ABCB1 (P-glycoprotein), which is implicated both in determining drug pharmacokinetics and multidrug resistance in human cancer cells, can affect protein conformation and function. We discuss the importance of polymorphisms in drug metabolizing enzymes and transporters in anticancer therapy and suggest that synonymous polymorphisms may play a more significant role than is currently assumed. [Cancer Res 2007; 67(20):9609-12] JF - Cancer Research AU - Sauna, Zuben E AU - Kimchi-Sarfaty, Chava AU - Ambudkar, Suresh V AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH and Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 9609 EP - 9612 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 20 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Protein structure KW - P-Glycoprotein KW - Single-nucleotide polymorphism KW - pharmacogenomics KW - Enzymes KW - Multidrug resistance KW - Cancer KW - Pharmacokinetics KW - G 07880:Human Genetics KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Silent+Polymorphisms+Speak%3A+How+They+Affect+Pharmacogenomics+and+the+Treatment+of+Cancer&rft.au=Sauna%2C+Zuben+E%3BKimchi-Sarfaty%2C+Chava%3BAmbudkar%2C+Suresh+V%3BGottesman%2C+Michael+M&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2007-10-01&rft.volume=67&rft.issue=20&rft.spage=9609&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein structure; Genomes; P-Glycoprotein; pharmacogenomics; Single-nucleotide polymorphism; Enzymes; Multidrug resistance; Pharmacokinetics; Cancer ER - TY - JOUR T1 - Polymorphisms in Apoptosis- and Proliferation-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among U.S. Radiologic Technologists AN - 19789544; 7610307 AB - Background: Although genes involved in apoptosis pathways and DNA repair pathways are both essential for maintaining genomic integrity, genetic variants in DNA repair have been thought to increase susceptibility to radiation carcinogenesis, but similar hypotheses have not generally been raised about apoptosis genes. For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women. Methods: In a case-control study of 859 cases and 1,083 controls within the U.S. Radiologic Technologists cohort, we assessed breast cancer risk with respect to 16 candidate variants in eight genes involved in apoptosis, inflammation, and proliferation. Using carefully reconstructed cumulative breast dose estimates from occupational and personal diagnostic ionizing radiation, we also investigated the joint effects of these polymorphisms on the risk of breast cancer. Results: In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the homozygous minor allele of CASP8 D302H [rs1045485, odds ratio (OR), 0.3; 95% confidence interval (95% CI), 0.1-0.8]. We found a significantly increased breast cancer risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P sub(trend) = 0.008. Assuming a dominant genetic model, IL1A A114S significantly modified the dose-response relationship between cumulative personal diagnostic radiation and breast cancer risk, adjusted for occupational dose (P sub(interaction) = 0.004). Conclusion: The U.S. Radiologic Technologists breast cancer study provided a unique opportunity to examine the joint effects of common genetic variation and ionizing radiation exposure to the breast using detailed occupational and personal diagnostic dose data. We found evidence of effect modification of the radiation and breast cancer dose-response relationship that should be confirmed in studies with more cases and controls and quantified radiation breast doses in the low-to-moderate range. (Cancer Epidemiol Biomarkers Prev 2007; 16(10):2000-7) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Doody, Michele M AU - Hauptmann, Michael AU - Bowen, Laura AU - Simon, Steven L AU - Weinstock, Robert M AU - Linet, Martha S AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Alexander, Bruce H AU - Preston, Dale L AU - Struewing, Jeffrey P AU - Rajaraman, Preetha AD - Radiation Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, and Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2000 EP - 2007 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 10 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Apoptosis KW - Gene polymorphism KW - Interleukin 1 KW - Joint diseases KW - Genetic diversity KW - Homozygotes KW - Models KW - Multivariate analysis KW - Dose-response effects KW - prevention KW - genomics KW - occupational exposure KW - Occupational exposure KW - Bioindicators KW - Data processing KW - genetic diversity KW - DNA repair KW - biomarkers KW - Cancer KW - Inflammation KW - USA KW - Ionizing radiation KW - Carcinogenesis KW - Heterozygotes KW - DNA KW - Breast cancer KW - X 24390:Radioactive Materials KW - R2 23080:Industrial and labor KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19789544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation%3A+The+International+Journal+of+Theory%2C+Research+and+Practice&rft.atitle=The+new+scalar+politics+of+evaluation%3A+An+emerging+governance+role+for+evaluation&rft.au=Rutkowski%2C+David%3BSparks%2C+Jason&rft.aulast=Rutkowski&rft.aufirst=David&rft.date=2014-10-01&rft.volume=20&rft.issue=4&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Evaluation%3A+The+International+Journal+of+Theory%2C+Research+and+Practice&rft.issn=13563890&rft_id=info:doi/10.1177%2F1356389014550561 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Gene polymorphism; Interleukin 1; Joint diseases; Genetic diversity; DNA repair; biomarkers; Homozygotes; Inflammation; Models; Multivariate analysis; Ionizing radiation; Dose-response effects; Heterozygotes; Carcinogenesis; Breast cancer; genomics; Occupational exposure; Bioindicators; prevention; DNA; genetic diversity; occupational exposure; Cancer; USA ER - TY - JOUR T1 - Identification and Characterization of Potential Sources of Worker Exposure to Carbon Nanofibers During Polymer Composite Laboratory Operations AN - 19579449; 8502007 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Mazzuckelli, Lawrence F AU - Methner, Mark M AU - Birch, M Eileen AU - Evans, Douglas E AU - Ku, Bon-Ki AU - Crouch, Keith AU - Hoover, Mark D AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - D125 EP - D130 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Fibers KW - Composite materials KW - composite materials KW - Polymers KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19579449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Identification+and+Characterization+of+Potential+Sources+of+Worker+Exposure+to+Carbon+Nanofibers+During+Polymer+Composite+Laboratory+Operations&rft.au=Mazzuckelli%2C+Lawrence+F%3BMethner%2C+Mark+M%3BBirch%2C+M+Eileen%3BEvans%2C+Douglas+E%3BKu%2C+Bon-Ki%3BCrouch%2C+Keith%3BHoover%2C+Mark+D&rft.aulast=Mazzuckelli&rft.aufirst=Lawrence&rft.date=2007-10-01&rft.volume=4&rft.issue=12&rft.spage=D125&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701683871 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Composite materials; Fibers; composite materials; Polymers; Occupational exposure DO - http://dx.doi.org/10.1080/15459620701683871 ER - TY - JOUR T1 - Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes. AN - 68285611; 17543367 AB - To determine the importance of dengue 2 virus (DEN2V) envelope (E) protein glycosylation, virus mutants in one or both of the N-linked glycosylation motifs were prepared. We found that while the E2 mutant virus (N153Q) replicated in mammalian and mosquito cells, the E1 (N67Q) and E1/2 (N67Q and N153Q) mutant viruses were unable to grow in mammalian cells. Infection of C6/36 mosquito cells with either the E1 or E1/2 mutants resulted in the introduction of a compensatory mutation, K64N, restoring glycosylation in the area. All mutants replicated similarly in inoculated Aedes aegypti mosquitoes, with no change in their mutations. These results suggest that N-linked glycosylation of the E protein is not necessary for DEN2V replication in mosquitoes, however N-linked glycosylation at amino acid N67 (or nearby N64) is critical for the survival of the virus in either mammalian or insect cell culture. JF - Virology AU - Bryant, Juliet E AU - Calvert, Amanda E AU - Mesesan, Kyeen AU - Crabtree, Mary B AU - Volpe, Katharine E AU - Silengo, Shawn AU - Kinney, Richard M AU - Huang, Claire Y-H AU - Miller, Barry R AU - Roehrig, John T AD - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA. Y1 - 2007/09/30/ PY - 2007 DA - 2007 Sep 30 SP - 415 EP - 423 VL - 366 IS - 2 SN - 0042-6822, 0042-6822 KW - E-glycoprotein, Dengue virus type 2 KW - 0 KW - Viral Envelope Proteins KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Amino Acid Substitution -- genetics KW - Humans KW - Glycosylation KW - Cell Line KW - Dengue Virus -- growth & development KW - Aedes -- virology KW - Viral Envelope Proteins -- metabolism KW - Dengue Virus -- genetics KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68285611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Glycosylation+of+the+dengue+2+virus+E+protein+at+N67+is+critical+for+virus+growth+in+vitro+but+not+for+growth+in+intrathoracically+inoculated+Aedes+aegypti+mosquitoes.&rft.au=Bryant%2C+Juliet+E%3BCalvert%2C+Amanda+E%3BMesesan%2C+Kyeen%3BCrabtree%2C+Mary+B%3BVolpe%2C+Katharine+E%3BSilengo%2C+Shawn%3BKinney%2C+Richard+M%3BHuang%2C+Claire+Y-H%3BMiller%2C+Barry+R%3BRoehrig%2C+John+T&rft.aulast=Bryant&rft.aufirst=Juliet&rft.date=2007-09-30&rft.volume=366&rft.issue=2&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-30 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bortezomib for the treatment of mantle cell lymphoma. AN - 68282766; 17875757 AB - To describe the Food and Drug Administration review and marketing approval considerations for bortezomib (Velcade) for the treatment of patients with mantle cell lymphoma. Food and Drug Administration reviewed a multicenter study of bortezomib in 155 patients with progressive mantle cell lymphoma after at least one prior therapy. Seventy-seven percent were stage IV, and 75% had one or more extranodal sites of disease. Prior therapy included an anthracycline or mitoxantrone, cyclophosphamide, and rituximab. Median age was 65 years. All received bortezomib 1.3 mg/m(2) i.v. on days 1, 4, 8, and 11 of each 3-week cycle. The primary end point was response. Response and progression were determined by independent review of serial computed tomography scans using International Lymphoma Workshop Response Criteria. The overall response rate was 31%, including complete response (CR) plus CR unconfirmed (CRu) plus partial response; median response duration was 9.3 months. The CR plus CRu response rate was 8% with a median duration of 15.4 months. Adverse events were similar to those observed previously for bortezomib. The most commonly reported treatment-emergent adverse events were asthenia (72%), peripheral neuropathies (55%), constipation (50%), diarrhea (47%), nausea (44%), and anorexia (39%). The most common adverse event leading to discontinuation was neuropathy. Bortezomib received regular approval for the treatment of patients with mantle cell lymphoma in relapse after prior therapy. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kane, Robert C AU - Dagher, Ramzi AU - Farrell, Ann AU - Ko, Chia-Wen AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Division of Drug Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. robert.kane@fda.hhs.gov Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 5291 EP - 5294 VL - 13 IS - 18 Pt 1 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Boronic Acids KW - Pyrazines KW - Bortezomib KW - 69G8BD63PP KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Prospective Studies KW - Humans KW - Drug Approval KW - Aged KW - Male KW - Female KW - Pyrazines -- therapeutic use KW - Lymphoma, Mantle-Cell -- drug therapy KW - Boronic Acids -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Boronic Acids -- therapeutic use KW - Pyrazines -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68282766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Bortezomib+for+the+treatment+of+mantle+cell+lymphoma.&rft.au=Kane%2C+Robert+C%3BDagher%2C+Ramzi%3BFarrell%2C+Ann%3BKo%2C+Chia-Wen%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2007-09-15&rft.volume=13&rft.issue=18+Pt+1&rft.spage=5291&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats AN - 20352007; 7611060 AB - Many welders have experienced bronchitis, metal fume fever, lung function changes, and an increase in the incidence of lung infection. Questions remain regarding the possible mechanisms associated with the potential pulmonary effects of welding fume exposure. The objective was to assess the early effects of stainless steel (SS) welding fume inhalation on lung injury, inflammation, and defense responses. Male Sprague-Dawley rats were exposed to gas metal arc-SS welding fume at a concentration of 15 or 40 mg/m super(3)x3 h/day for 1, 3, or 10 days. The control group was exposed to filtered air. To assess lung defense responses, some animals were intratracheally inoculated with 5x10 super(4)Listeria monocytogenes 1 day after the last exposure. Welding particles were collected during exposure, and elemental composition and particle size were determined. At 1, 4, 6, 11, 14, and 30 days after the final exposure, parameters of lung injury (lactate dehydrogenase and albumin) and inflammation (PMN influx) were measured in the bronchoalveolar lavage fluid. In addition, particle-induced effects on pulmonary clearance of bacteria and macrophage function were assessed. SS particles were composed of Fe, Cr, Mn, and Ni. Particle size distribution analysis indicated the mass median aerodynamic diameter of the generated fume to be 0.255 mu m. Parameters of lung injury were significantly elevated at all time points post-exposure compared to controls except for 30 days. Interestingly, no significant difference in lung PMNs was observed between the SS and control groups at 1, 4, and 6 days post-exposure. After 6 days post-exposure, a dramatic increase in lung PMNs was observed in the SS group compared to air controls. Lung bacteria clearance and macrophage function were reduced and immune and inflammatory cytokines were altered in the SS group. In summary, short-term exposure of rats to SS welding fume caused significant lung damage and suppressed lung defense responses to bacterial infection, but had a delayed effect on pulmonary inflammation. Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure. JF - Toxicology and Applied Pharmacology AU - Antonini, J M AU - Stone, S AU - Roberts, J R AU - Chen, B AU - Schwegler-Berry, D AU - Afshari, A A AU - Frazer, D G AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA, jga6@cdc.gov Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 234 EP - 245 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 223 IS - 3 SN - 0041-008X, 0041-008X KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Inhalation KW - Metals KW - Fumes KW - Injuries KW - Chromium KW - Infection KW - Alveoli KW - L-Lactate dehydrogenase KW - Inflammation KW - Fever KW - Bronchus KW - Lung KW - Albumin KW - Cytokines KW - Welding KW - Bronchitis KW - Manganese KW - Size distribution KW - stainless steel KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02320:Cell Biology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effect+of+short-term+stainless+steel+welding+fume+inhalation+exposure+on+lung+inflammation%2C+injury%2C+and+defense+responses+in+rats&rft.au=Antonini%2C+J+M%3BStone%2C+S%3BRoberts%2C+J+R%3BChen%2C+B%3BSchwegler-Berry%2C+D%3BAfshari%2C+A+A%3BFrazer%2C+D+G&rft.aulast=Antonini&rft.aufirst=J&rft.date=2007-09-15&rft.volume=223&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Macrophages; Metals; Fumes; Chromium; Injuries; Infection; Alveoli; Inflammation; L-Lactate dehydrogenase; Fever; Bronchus; Lung; Albumin; Welding; Cytokines; Bronchitis; Manganese; Size distribution; stainless steel DO - http://dx.doi.org/10.1016/j.taap.2007.06.020 ER - TY - JOUR T1 - Human papillomavirus and cervical cancer. AN - 68249069; 17826171 AB - Cervical cancer is the second most common cancer in women worldwide, and knowledge regarding its cause and pathogenesis is expanding rapidly. Persistent infection with one of about 15 genotypes of carcinogenic human papillomavirus (HPV) causes almost all cases. There are four major steps in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zone, viral persistence, progression of persistently infected epithelium to cervical precancer, and invasion through the basement membrane of the epithelium. Infection is extremely common in young women in their first decade of sexual activity. Persistent infections and precancer are established, typically within 5-10 years, from less than 10% of new infections. Invasive cancer arises over many years, even decades, in a minority of women with precancer, with a peak or plateau in risk at about 35-55 years of age. Each genotype of HPV acts as an independent infection, with differing carcinogenic risks linked to evolutionary species. Our understanding has led to improved prevention and clinical management strategies, including improved screening tests and vaccines. The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology. If applied wisely, HPV-related technology can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings. JF - Lancet (London, England) AU - Schiffman, Mark AU - Castle, Philip E AU - Jeronimo, Jose AU - Rodriguez, Ana C AU - Wacholder, Sholom AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. schiffmm@mail.nih.gov Y1 - 2007/09/08/ PY - 2007 DA - 2007 Sep 08 SP - 890 EP - 907 VL - 370 IS - 9590 KW - Papillomavirus Vaccines KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Female KW - Uterine Cervical Neoplasms -- prevention & control KW - Human papillomavirus 16 -- pathogenicity KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- pathology KW - Uterine Cervical Neoplasms -- mortality KW - Papillomavirus Infections -- complications KW - Papillomavirus Vaccines -- therapeutic use KW - Human papillomavirus 16 -- genetics KW - Papillomavirus Vaccines -- adverse effects KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68249069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Human+papillomavirus+and+cervical+cancer.&rft.au=Schiffman%2C+Mark%3BCastle%2C+Philip+E%3BJeronimo%2C+Jose%3BRodriguez%2C+Ana+C%3BWacholder%2C+Sholom&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - FDA Perspectives on Validation of Multiplex Proteomic Biomarkers. T2 - 2007 Conference on Protein Discovery and Development AN - 39420182; 4662328 JF - 2007 Conference on Protein Discovery and Development AU - Philip, Reena Y1 - 2007/09/06/ PY - 2007 DA - 2007 Sep 06 KW - Bioindicators KW - FDA KW - Proteomics KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39420182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Protein+Discovery+and+Development&rft.atitle=FDA+Perspectives+on+Validation+of+Multiplex+Proteomic+Biomarkers.&rft.au=Philip%2C+Reena&rft.aulast=Philip&rft.aufirst=Reena&rft.date=2007-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Protein+Discovery+and+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/conference/userAgenda.aspx?id=92 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Offered Paper Detection and Characterisation of Cryptosporidium sp. Seeing the Whole Picture through Evidence Based Methodology T2 - 61st Meeting of the Society for General Microbiology (SGM 2007) AN - 39512509; 4674888 JF - 61st Meeting of the Society for General Microbiology (SGM 2007) AU - Elwin, K Y1 - 2007/09/03/ PY - 2007 DA - 2007 Sep 03 KW - Pathogens KW - Food KW - Cryptosporidium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39512509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Meeting+of+the+Society+for+General+Microbiology+%28SGM+2007%29&rft.atitle=Offered+Paper+Detection+and+Characterisation+of+Cryptosporidium+sp.+Seeing+the+Whole+Picture+through+Evidence+Based+Methodology&rft.au=Elwin%2C+K&rft.aulast=Elwin&rft.aufirst=K&rft.date=2007-09-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Meeting+of+the+Society+for+General+Microbiology+%28SGM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.socgenmicrobiol.org.uk/meetings/MTGPAGES/Edinburgh07.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Baseline behavior, but not sensitivity to stimulant drugs, differs among spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rat strains. AN - 68441425; 17689921 AB - Deficits in temporal processing are implicated in Attention Deficit Hyperactivity Disorder (ADHD) for which the most common rodent model is the Spontaneously Hypertensive Rat (SHR). To assess strain differences in temporal processing, males and females of the SHR, Wistar-Kyoto (WKY), and Sprague-Dawley (SD) strains were compared on two timing tasks: one requiring maintenance of a lever press for 10-14 s (TRD, temporal response differentiation) and the other requiring withholding of a lever press for 10-14 s (DRL, differential reinforcement of low rates). Performance of the progressive ratio (PR) task more directly assessed food-motivated behavior. Strains did not differ in task acquisition; however, steady state TRD and DRL performance of the SHR and WKY strains was less accurate which was related to increased burst (non-timing related) responses in those strains relative to the SD. PR performance demonstrated that the SHR and WKY strains exhibited higher response rates and breakpoints than the SD. Subsequently, methylphenidate (1, 3.25, 4.50, 7.50, and 12.0 mg/kg) and d-amphetamine (0.1, 0.25, 0.65, 1.0, and 2.0 mg/kg) were administered intraperitoneally pre-testing. Both drugs disrupted TRD and DRL performances by increasing burst response frequency; however, the strains were not differentially sensitive to either drug. Strain differences were generally maintained throughout the drug and extinction portions of the study. These results indicate increased similarity between the SHR and WKY strains relative to the SD in performance of timing and motivation tasks. Further, the current results do not support continued use of the SHR as a model for ADHD. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Paule, Merle G AU - Cada, Amy AU - Fogle, C Matthew AU - Gray, Erika P AU - Berry, Kimberly J AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA. Sherry.Ferguson@fda.hhs.gov PY - 2007 SP - 547 EP - 561 VL - 29 IS - 5 SN - 0892-0362, 0892-0362 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Reinforcement Schedule KW - Rats, Inbred SHR KW - Rats, Inbred WKY KW - Dose-Response Relationship, Drug KW - Methylphenidate -- pharmacology KW - Dextroamphetamine -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Body Weight -- drug effects KW - Species Specificity KW - Female KW - Male KW - Central Nervous System Stimulants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68441425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Baseline+behavior%2C+but+not+sensitivity+to+stimulant+drugs%2C+differs+among+spontaneously+hypertensive%2C+Wistar-Kyoto%2C+and+Sprague-Dawley+rat+strains.&rft.au=Ferguson%2C+Sherry+A%3BPaule%2C+Merle+G%3BCada%2C+Amy%3BFogle%2C+C+Matthew%3BGray%2C+Erika+P%3BBerry%2C+Kimberly+J&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2007-09-01&rft.volume=29&rft.issue=5&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study. AN - 68369030; 17475336 AB - Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson's-like syndromes in humans and animals. MPTP/MPP+ treatment produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been elucidated. In order to gain insights into MPP+-induced neurotoxicity, a gene expression microarray study was performed using a midbrain-derived dopaminergic neuronal cell line, MN9D. Utilizing a two-color reference design, Agilent mouse oligonucleotide microarrays were used to examine relative gene expression changes in MN9D cells treated with 40microM MPP+ compared with controls. Bioinformatics tools were used for data evaluation. Briefly, raw data were imported into the NCTR ArrayTrack database, normalized using a Lowess method and data quality was assessed. The Student's t-test was used to determine significant changes in gene expression (set as p1.5). Gene Ontology for Function Analysis (GOFFA) and Ingenuity Pathway Analysis were employed to analyze the functions and roles of significant genes in biological processes. Of the 51 significant genes identified, 44 were present in the GOFFA or Ingenuity database. These data indicate that multiple pathways are involved in the underlying mechanisms of MPP+-induced neurotoxicity, including apoptosis, oxidative stress, iron binding, cellular metabolism, and signal transduction. These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms. JF - Neurotoxicology AU - Wang, Jianyong AU - Xu, Zengjun AU - Fang, Hong AU - Duhart, Helen M AU - Patterson, Tucker A AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 979 EP - 987 VL - 28 IS - 5 SN - 0161-813X, 0161-813X KW - Dopamine Agents KW - 0 KW - Neurotransmitter Transport Proteins KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Animals KW - Neurotransmitter Transport Proteins -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - Cell Division -- physiology KW - Oxidative Stress -- genetics KW - Mice KW - Electric Stimulation KW - Neurotransmitter Transport Proteins -- genetics KW - Gene Expression Profiling KW - Apoptosis -- genetics KW - Cells, Cultured KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Signal Transduction -- genetics KW - Oxidative Stress -- drug effects KW - Data Interpretation, Statistical KW - Cluster Analysis KW - Cell Division -- genetics KW - Dopamine Agents -- toxicity KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Neurons -- pathology KW - MPTP Poisoning -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68369030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Gene+expression+profiling+of+MPP%2B-treated+MN9D+cells%3A+a+mechanism+of+toxicity+study.&rft.au=Wang%2C+Jianyong%3BXu%2C+Zengjun%3BFang%2C+Hong%3BDuhart%2C+Helen+M%3BPatterson%2C+Tucker+A%3BAli%2C+Syed+F&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2007-09-01&rft.volume=28&rft.issue=5&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-26 N1 - Date created - 2007-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of chronic low-dose acrylamide exposure on progressive ratio performance in adolescent rats. AN - 68360204; 17720246 AB - Acrylamide (ACR) is a neurotoxicant known to produce peripheral neuropathy in rats and humans, but little is known of its potential for producing cognitive or motivational alterations. Chronic exposure to low doses of ACR as a food contaminant is known to occur widely in humans. This research evaluated the effects of daily ACR exposure on food-motivated behavior, with exposures beginning prenatally on gestation day 6 and continuing through approximately postnatal day (PND) 85. Plug-positive Fischer 344 dams (9-10 per dose) were gavaged daily with 0, 0.1, 0.3, 1.0 or 5.0mg/kg/day ACR. On PNDs 1-22, pups were gavaged with the same dose their dam had received. On PND 22, pups were weaned and pair-housed with a same-sex littermate and ACR exposure continued at 0, 1, 3, 10 and 50ppm via drinking water. One male and one female pup per litter were tested in an operant chamber under a progressive ratio (PR) schedule of food reinforcement from approximately 6 to 12 weeks of age. Results over 6 weeks of testing indicated a significant treatment effect of ACR on number of reinforcers earned, with Tukey HSD post hoc tests revealing significantly fewer reinforcers earned in the 5.0mg/kg/day dose group than in controls. A significant effect of ACR on response rate was also observed, with the Tukey HSD post hoc tests revealing a significantly lower response rate in the 5.0mg/kg/day group than in controls. No effects of ACR were observed on post-reinforcement pause. These data suggest that daily ACR exposure at 5.0mg/kg/day can produce measurable decrements on aspects of food-motivated behavior. JF - Neurotoxicology AU - Garey, Joan AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA. joan.garey@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 998 EP - 1002 VL - 28 IS - 5 SN - 0161-813X, 0161-813X KW - Acrylamide KW - 20R035KLCI KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Reinforcement Schedule KW - Motivation KW - Body Weight -- drug effects KW - Male KW - Female KW - Pregnancy KW - Conditioning, Operant -- drug effects KW - Psychomotor Performance -- drug effects KW - Acrylamide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68360204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+chronic+low-dose+acrylamide+exposure+on+progressive+ratio+performance+in+adolescent+rats.&rft.au=Garey%2C+Joan%3BPaule%2C+Merle+G&rft.aulast=Garey&rft.aufirst=Joan&rft.date=2007-09-01&rft.volume=28&rft.issue=5&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-26 N1 - Date created - 2007-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - What is being done to address the new drug epidemic? AN - 68333604; 17908827 AB - As osteopathic physicians care for patients with complaints of pain, they commonly prescribe controlled substances. The use of these agents presents special challenges for providers, patients, and communities. The US Drug Enforcement Administration (DEA) has provided testimony to the US Congress in regard to the growing problem of diversion and misuse of such medications. Joseph T. Rannazzisi, the deputy assistant administrator in the Office of Diversion Control, appeared before the House Government Reform Committee's Subcommittee on Criminal Justice, Drug Policy, and Human Resources on July 26, 2006. JF - The Journal of the American Osteopathic Association AU - Dekker, Anthony H AD - Phoenix Indian Medical Center, Indian Health Service, USPHS, 4212 N 16th Street, Phoenix, AZ 85016-5319, USA. Anthony.Dekker@ihs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - ES21 EP - ES26 VL - 107 IS - 9 Suppl 5 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - Opioid-Related Disorders -- epidemiology KW - Pain, Intractable -- drug therapy KW - Drug and Narcotic Control -- trends KW - Drug Prescriptions -- standards KW - Drug and Narcotic Control -- legislation & jurisprudence KW - Analgesics, Opioid -- therapeutic use KW - Analgesics, Opioid -- adverse effects KW - Opioid-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68333604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+American+Osteopathic+Association&rft.atitle=What+is+being+done+to+address+the+new+drug+epidemic%3F&rft.au=Dekker%2C+Anthony+H&rft.aulast=Dekker&rft.aufirst=Anthony&rft.date=2007-09-01&rft.volume=107&rft.issue=9+Suppl+5&rft.spage=ES21&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+American+Osteopathic+Association&rft.issn=1945-1997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity assessment of unintentional exposure to multiple chemicals. AN - 68247386; 17599373 AB - Typically exposure to environmental chemicals is unintentional, and often the exposure is to chemical mixtures, either simultaneously or sequentially. When exposure occurs, in public health practice, it is prudent to ascertain if thresholds for harmful health effects are exceeded, whether by individual chemicals or by chemicals in combination. Three alternative approaches are available for assessing the toxicity of chemical mixtures. Each approach, however, has shortcomings. As the procedures of each approach are described in this paper, at various steps research needs are identified. Recently, reliance has increased on computational toxicology methods for predicting toxicological effects when data are limited. Advances in molecular biology, identification of biomarkers, and availability of accurate and sensitive methods allow us to more precisely define the relationships between multiple chemical exposures and health effects, both qualitatively and quantitatively. Key research needs are best fulfilled through collaborative research. It is through such collaborations that resources are most effectively leveraged to further develop and apply toxicity assessment methods that advance public health practices in vulnerable communities. JF - Toxicology and applied pharmacology AU - Mumtaz, M M AU - Ruiz, P AU - De Rosa, C T AD - Division of Toxicology and Environmental Medicine Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. mgm4@cdc.gov Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 104 EP - 113 VL - 223 IS - 2 SN - 0041-008X, 0041-008X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Animals KW - Systems Integration KW - Humans KW - Computational Biology KW - Risk Assessment -- methods KW - Models, Theoretical KW - Toxicology -- trends KW - Environmental Exposure -- analysis KW - Hazardous Substances -- poisoning KW - Toxicology -- methods KW - Environmental Exposure -- prevention & control KW - Hazardous Substances -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68247386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Toxicity+assessment+of+unintentional+exposure+to+multiple+chemicals.&rft.au=Mumtaz%2C+M+M%3BRuiz%2C+P%3BDe+Rosa%2C+C+T&rft.aulast=Mumtaz&rft.aufirst=M&rft.date=2007-09-01&rft.volume=223&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-30 N1 - Date created - 2007-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stimulating the development of mechanism-based, individualized pain therapies. AN - 68225050; 17762885 AB - Biomedical science has greatly improved our understanding of pain in recent decades, but few novel molecular entities that address fundamentally new pain mechanisms have entered the clinic, despite dramatically increased pharmaceutical investment. Indeed, virtually all new analgesics approved over the past 25 years are derivatives or reformulations of opioids or aspirin-like drugs, existing drugs given for a new indication or older drugs given by a different route of administration. Here, we discuss factors contributing to this lack of innovation in therapies for pain and advocate public-private partnerships (PPPs) to translate new knowledge into more efficacious and safer treatments. JF - Nature reviews. Drug discovery AU - Woodcock, Janet AU - Witter, James AU - Dionne, Raymond A AD - Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 703 EP - 710 VL - 6 IS - 9 SN - 1474-1776, 1474-1776 KW - Analgesics KW - 0 KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Pain -- drug therapy KW - Analgesics -- pharmacology KW - Drug Design KW - Analgesics -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68225050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Nature+reviews.+Drug+discovery&rft.atitle=Stimulating+the+development+of+mechanism-based%2C+individualized+pain+therapies.&rft.au=Woodcock%2C+Janet%3BWitter%2C+James%3BDionne%2C+Raymond+A&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd2335 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-02-10 N1 - Last updated - 2017-02-10 DO - http://dx.doi.org/10.1038/nrd2335 ER - TY - JOUR T1 - Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR. AN - 68223253; 17526437 AB - This study describes the development of a mitochondria-specific microarray, MitoChip, to measure transcripts of mitochondria-associated genes in various diseases and drug-induced toxicities in the mouse. The array consists of 542 oligonucleotides that represent genes from the mitochondrial and nuclear genomes associated with mitochondrial structure and functions. The expression of mitochondrial genes was measured in the liver of both p53 haplodeficient (+/-) and wild-type (+/+) C3B6F(1) female mice exposed to antiretroviral agents, Zidovudine (AZT) and Lamivudine (3TC). Among genes whose expression was significantly altered, a set was selected for real-time PCR analysis to verify their differential gene expression. The real-time PCR data confirmed the observations by microarray analysis suggesting that the MitoChip may be an important tool for examining mitochondrial involvement in diseases and drug-induced toxicities. JF - Mitochondrion AU - Desai, Varsha G AU - Lee, Taewon AU - Delongchamp, Robert R AU - Moland, Carrie L AU - Branham, William S AU - Fuscoe, James C AU - Leakey, Julian E A AD - Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. varsha.desai@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 322 EP - 329 VL - 7 IS - 5 SN - 1567-7249, 1567-7249 KW - Lamivudine KW - 2T8Q726O95 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Zidovudine -- pharmacology KW - Lamivudine -- pharmacology KW - Mice KW - Male KW - Gene Expression Profiling -- methods KW - Female KW - Mitochondria -- physiology KW - Mitochondria -- drug effects KW - Oligonucleotide Array Sequence Analysis -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68223253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=Development+of+mitochondria-specific+mouse+oligonucleotide+microarray+and+validation+of+data+by+real-time+PCR.&rft.au=Desai%2C+Varsha+G%3BLee%2C+Taewon%3BDelongchamp%2C+Robert+R%3BMoland%2C+Carrie+L%3BBranham%2C+William+S%3BFuscoe%2C+James+C%3BLeakey%2C+Julian+E+A&rft.aulast=Desai&rft.aufirst=Varsha&rft.date=2007-09-01&rft.volume=7&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=15677249&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Follow-up study of chrysotile textile workers: cohort mortality and exposure-response. AN - 68183340; 17449563 AB - This report provides an update of the mortality experience of a cohort of South Carolina asbestos textile workers. A cohort of 3072 workers exposed to chrysotile in a South Carolina asbestos textile plant (1916-77) was followed up for mortality through 2001. Standardised mortality ratios (SMRs) were computed using US and South Carolina mortality rates. A job exposure matrix provided calendar time dependent estimates of chrysotile exposure concentrations. Poisson regression models were fitted for lung cancer and asbestosis. Covariates considered included sex, race, age, calendar time, birth cohort and time since first exposure. Cumulative exposure lags of 5 and 10 years were considered by disregarding exposure in the most recent 5 and 10 years, respectively. A majority of the cohort was deceased (64%) and 702 of the 1961 deaths occurred since the previous update. Mortality was elevated based on US referent rates for a priori causes of interest including all causes combined (SMR 1.33, 95% CI 1.28 to 1.39); all cancers (SMR 1.27, 95% CI 1.16 to 1.39); oesophageal cancer (SMR 1.87, 95% CI 1.09 to 2.99); lung cancer (SMR 1.95, 95% CI 1.68 to 2.24); ischaemic heart disease (SMR 1.20, 95% CI 1.10 to 1.32); and pneumoconiosis and other respiratory diseases (SMR 4.81, 95% CI 3.84 to 5.94). Mortality remained elevated for these causes when South Carolina referent rates were used. Three cases of mesothelioma were observed among cohort members. Exposure-response modelling for lung cancer, using a linear relative risk model, produced a slope coefficient of 0.0198 (fibre-years/ml) (standard error 0.00496), when cumulative exposure was lagged 10 years. Poisson regression modelling confirmed significant positive relations between estimated chrysotile exposure and lung cancer and asbestosis mortality observed in previous updates of this cohort. This study confirms the findings from previous investigations of excess mortality from lung cancer and asbestosis and a strong exposure-response relation between estimated exposure to chrysotile and mortality from lung cancer and asbestosis. JF - Occupational and environmental medicine AU - Hein, Misty J AU - Stayner, Leslie T AU - Lehman, Everett AU - Dement, John M AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. MHein@cdc.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 616 EP - 625 VL - 64 IS - 9 KW - Asbestos, Serpentine KW - 0 KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Asbestos, Serpentine -- toxicity KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Textile Industry -- statistics & numerical data KW - Lung Neoplasms -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68183340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Follow-up+study+of+chrysotile+textile+workers%3A+cohort+mortality+and+exposure-response.&rft.au=Hein%2C+Misty+J%3BStayner%2C+Leslie+T%3BLehman%2C+Everett%3BDement%2C+John+M&rft.aulast=Hein&rft.aufirst=Misty&rft.date=2007-09-01&rft.volume=64&rft.issue=9&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Occup Hyg. 2000 Dec;44(8):565-601 [11108782] J Occup Environ Med. 2006 Jul;48(7):662-7 [16832222] Ann Epidemiol. 2002 Aug;12(6):363-9 [12160594] Ann Epidemiol. 2004 Oct;14(9):633-9 [15380793] Int J Epidemiol. 2004 Oct;33(5):1040-5 [15155700] Occup Environ Med. 2004 Nov;61(11):930-5 [15477287] Am J Epidemiol. 1982 Jul;116(1):177-88 [7102651] J Occup Med. 1983 Feb;25(2):115-24 [6687607] Am J Ind Med. 1983;4(3):399-419 [6846338] Am J Ind Med. 1983;4(3):421-33 [6846339] J Occup Med. 1990 Nov;32(11):1091-8 [2258764] J Occup Med. 1994 Aug;36(8):882-8 [7807269] Am J Ind Med. 1994 Oct;26(4):431-47 [7810543] Risk Anal. 1995 Apr;15(2):181-95 [7597255] Stat Med. 1995 Oct 15;14(19):2119-29 [8552891] Am J Public Health. 1996 Feb;86(2):179-86 [8633733] Am J Public Health. 1996 Feb;86(2):231-6 [8633741] Ann Occup Hyg. 1997 Dec;41(6):699-705 [9375528] Occup Environ Med. 1997 Sep;54(9):646-52 [9423577] Am J Epidemiol. 1999 Feb 15;149(4):347-52 [10025477] Ind Health. 1999 Jul;37(3):271-80 [10441898] Radiat Res. 1999 Oct;152(4):339-51 [10477911] Am J Epidemiol. 2001 Sep 15;154(6):538-43 [11549559] N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Mining Facts 2004 AN - 58774182; 2008-150288 AB - Gives statistics for employment, fatalities and injuries in the mining industry in 2004. Tables, Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2007, 4 pp. AU - National Institute Occupational Safety and Health Y1 - 2007/09// PY - 2007 DA - September 2007 EP - 4p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Employment and labor supply KW - Science and technology policy - Biology and biotechnology KW - Social conditions and policy - Public safety and security KW - Environment and environmental policy - Mining and mineral resources KW - Accidents KW - Death KW - Personal injuries KW - Miners KW - Employment KW - Mining industry KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58774182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+Occupational+Safety+and+Health&rft.aulast=National+Institute+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Mining+Facts+2004&rft.title=Mining+Facts+2004&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2007-166.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - SuppNotes - NIOSH Publication No. 2007-166 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Reducing Pesticide Exposure at Schools AN - 58762521; 2008-150287 AB - Pesticides play an important role in food supply protection and disease control, but they can also be harmful to human health. The term pesticide applies to insecticides, herbicides, fungicides, disinfectants and various other substances used to control pests. Pesticides are often applied at schools to help maintain sanitary conditions and suppress rodents and insect populations. Exposures and potential health risks to children and school staff can be reduced by avoiding routine pesticide applications through an Integrated Pest Management (IPM) program. Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2007, 4 pp. AU - National Inst Occupational Safety and Health Y1 - 2007/09// PY - 2007 DA - September 2007 EP - 4p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Education and education policy - Schools KW - Environment and environmental policy - Radioactive and dangerous substances KW - Schools KW - Hazardous materials KW - Pesticides KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58762521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Reducing+Pesticide+Exposure+at+Schools&rft.title=Reducing+Pesticide+Exposure+at+Schools&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2007-150/pdfs/2007-150.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - SuppNotes - Niosh Publication No. 2007-150 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Area Under the Curve and Other Summary Indicators of Repeated Waking Cortisol Measurements AN - 57314145; 200811472 AB - Objective: To derive the area under the curve and related summary measures of stress from saliva samples collected over time and to provide insight into the interpretation of the derived parameters. In research designed to assess the health consequences of stress these samples are often used as a physiologic indicator of the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis. To make these repeated measurements of salivary cortisol more useful in defining the relationships between stress and health there is a need to derive two forms of area under the curve that summarize the measurements: area under the curve with respect to ground (AUCG) and area under the curve with respect to increase (AUCI). The latter parameters, AUCI, however, is seldom used by research scientists. Methods: In this study, interpretation and generic definition of the area under the curve was provided through graphical analyses and examination of its association with other summary measures using data from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Pilot Study. In generic form, AUCI is derived as the area under the curve above the baseline value minus the area above the curve below the baseline value. Results: The sign and magnitude of AUCI are related to the profile and the rate of change of the measurements over time. The parameter showed significant associations with other summary indicators that measure pattern or rate of change of the measurements over time. Conclusion: Principal components analyses revealed that summary parameters derived from repeated cortisol measurements can be grouped into two meaningful general categories: measures of the magnitude of response and measures of the pattern of response over time. Adapted from the source document. JF - Psychosomatic Medicine AU - Fekedulegn, Desta B AU - Andrew, Michael E AU - Burchfiel, Cecil M AU - Violanti, John M AU - Hartley, Tara A AU - Charles, Luenda E AU - Miller, Diane B AD - Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD/BEB, MS 4050, 1095 Willowdale Rd., Morgantown, WV 26505 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 651 EP - 659 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 69 IS - 7 SN - 0033-3174, 0033-3174 KW - repeated cortisol measurements, area under the curve, principal component analysis, total hormonal secretion, time course of salivary cortisol KW - Parameters KW - Measurement KW - Magnitude KW - Cortisol KW - Salivary cortisol KW - Stress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Area+Under+the+Curve+and+Other+Summary+Indicators+of+Repeated+Waking+Cortisol+Measurements&rft.au=Fekedulegn%2C+Desta+B%3BAndrew%2C+Michael+E%3BBurchfiel%2C+Cecil+M%3BViolanti%2C+John+M%3BHartley%2C+Tara+A%3BCharles%2C+Luenda+E%3BMiller%2C+Diane+B&rft.aulast=Fekedulegn&rft.aufirst=Desta&rft.date=2007-09-01&rft.volume=69&rft.issue=7&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e31814c405c LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMEAP N1 - SubjectsTermNotLitGenreText - Measurement; Stress; Parameters; Magnitude; Cortisol; Salivary cortisol DO - http://dx.doi.org/10.1097/PSY.0b013e31814c405c ER - TY - JOUR T1 - Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study AN - 57216321; 200803987 AB - Background: Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv)psychomotor speed, could be improved by this intervention. Method: We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain. Results: Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables. Conclusions: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD. Adapted from the source document. JF - Psychological Medicine AU - Elgamal, Safa AU - McKinnon, Margaret C AU - Ramakrishnan, Karun AU - Joffe, Russell T AU - MacQueen, Glenda AD - St Joseph's Center for Mental Health Services, DI, Mood Disorders Program, 100 West 5th St, Hamilton, ON, Canada L8N 3K7 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1229 EP - 1238 PB - Cambridge University Press, UK VL - 37 IS - 9 SN - 0033-2917, 0033-2917 KW - Memory KW - Cognitive deficits KW - Depression KW - Computer assisted training KW - Attention KW - Executive function KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Successful+computer-assisted+cognitive+remediation+therapy+in+patients+with+unipolar+depression%3A+a+proof+of+principle+study&rft.au=Elgamal%2C+Safa%3BMcKinnon%2C+Margaret+C%3BRamakrishnan%2C+Karun%3BJoffe%2C+Russell+T%3BMacQueen%2C+Glenda&rft.aulast=Elgamal&rft.aufirst=Safa&rft.date=2007-09-01&rft.volume=37&rft.issue=9&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291707001110 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Depression; Computer assisted training; Cognitive deficits; Attention; Memory; Executive function DO - http://dx.doi.org/10.1017/S0033291707001110 ER - TY - JOUR T1 - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome AN - 20338177; 7616787 AB - Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation. JF - Proceedings of the National Academy of Sciences, USA AU - Marenco, Stefano AU - Siuta, Michael A AU - Kippenhan, JShane AU - Grodofsky, Samuel AU - Chang, Wei-li AU - Kohn, Philip AU - Mervis, Carolyn B AU - Morris, Colleen A AU - Weinberger, Daniel R AU - Meyer-Lindenberg, Andreas AU - Pierpaoli, Carlo AU - Berman, Karen Faith AD - Clinical Brain Disorders Branch (CBDB), Genes Cognition and Psychosis Program (GCAP), Intramural Research Program (IRP), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD 20892 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 15117 EP - 15122 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 38 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Neurodevelopmental disorders KW - Magnetic resonance imaging KW - LIM kinase KW - Substantia alba KW - Cognition KW - chromosome 7 KW - Cytoskeleton KW - Fibers KW - Neurons KW - Genetic control KW - Cell migration KW - Williams syndrome KW - W 30910:Imaging KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Genetic+contributions+to+white+matter+architecture+revealed+by+diffusion+tensor+imaging+in+Williams+syndrome&rft.au=Marenco%2C+Stefano%3BSiuta%2C+Michael+A%3BKippenhan%2C+JShane%3BGrodofsky%2C+Samuel%3BChang%2C+Wei-li%3BKohn%2C+Philip%3BMervis%2C+Carolyn+B%3BMorris%2C+Colleen+A%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas%3BPierpaoli%2C+Carlo%3BBerman%2C+Karen+Faith&rft.aulast=Marenco&rft.aufirst=Stefano&rft.date=2007-09-01&rft.volume=104&rft.issue=38&rft.spage=15117&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Neurodevelopmental disorders; Fibers; Neurons; LIM kinase; Magnetic resonance imaging; Substantia alba; Genetic control; Cell migration; Williams syndrome; Cognition; chromosome 7 ER - TY - JOUR T1 - Toward a Checklist for Exchange and Interpretation of Data from a Toxicology Study AN - 19747088; 7561131 AB - Data from toxicology and toxicogenomics studies are valuable, and can be combined for meta-analysis using public data repositories such as Chemical Effects in Biological Systems Knowledgebase, ArrayExpress, and Gene Expression Omnibus. In order to fully utilize the data for secondary analysis, it is necessary to have a description of the study and good annotation of the accompanying data. This study annotation permits sophisticated cross-study comparison and analysis, and allows data from comparable subjects to be identified and fully understood. The Minimal Information About a Microarray Experiment Standard was proposed to permit deposition and sharing of microarray data. We propose the first step toward an analogous standard for a toxicogenomics/toxicology study, by describing a checklist of information that best practices would suggest be included with the study data. When the information in this checklist is deposited together with the study data, the checklist information helps the public explore the study data in context of time, or identify data from similarly treated subjects, and also explore/identify potential sources of experimental variability. The proposed checklist summarizes useful information to include when sharing study data for publication, deposition into a database, or electronic exchange with collaborators. It is not a description of how to carry out an experiment, but a definition of how to describe an experiment. It is anticipated that once a toxicology checklist is accepted and put into use, then toxicology databases can be configured to require and output these fields, making it straightforward to annotate data for interpretation by others. JF - Toxicological Sciences AU - Fostel, Jennifer M AU - Burgoon, Lyle AU - Zwickl, Craig AU - Lord, Peter AU - Corton, JChristopher AU - Bushel, Pierre R AU - Cunningham, Michael AU - Fan, Liju AU - Edwards, Stephen W AU - Hester, Susan AU - Stevens, James AU - Tong, Weida AU - Waters, Michael AU - Yang, ChiHae AU - Tennant, Raymond AD - NIEHS, LMIT ITSS Contract, Research Triangle Park, North Carolina 27709-2233. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824. Lilly Research Laboratory, Greenfield, Indiana 46140. Johnson and Johnson PRD, Raritan, New Jersey 08869. National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. NIEHS, Research Triangle Park, North Carolina 27709-2233. National Toxicology Program, Research Triangle Park, North Carolina 27709. Ontology Workshop, LLC, Columbia, Maryland 21045-9998. National Center for Toxicological Research, Jefferson, Arkansas 72079. Integrated Life Sciences, Research Triangle Park, North Carolina 27709. Leadscope, Columbus, Ohio 43212 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 26 EP - 34 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Gene expression KW - Databases KW - Data processing KW - Reviews KW - Check lists KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toward+a+Checklist+for+Exchange+and+Interpretation+of+Data+from+a+Toxicology+Study&rft.au=Fostel%2C+Jennifer+M%3BBurgoon%2C+Lyle%3BZwickl%2C+Craig%3BLord%2C+Peter%3BCorton%2C+JChristopher%3BBushel%2C+Pierre+R%3BCunningham%2C+Michael%3BFan%2C+Liju%3BEdwards%2C+Stephen+W%3BHester%2C+Susan%3BStevens%2C+James%3BTong%2C+Weida%3BWaters%2C+Michael%3BYang%2C+ChiHae%3BTennant%2C+Raymond&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Databases; Data processing; Reviews; Check lists ER - TY - JOUR T1 - A Nested Case-Control Study of Lung Cancer Risk and Ionizing Radiation Exposure at the Portsmouth Naval Shipyard AN - 19714069; 8196269 AB - Results have been inconsistent between studies of lung cancer risk and ionizing radiation exposures among workers at the Portsmouth Naval Shipyard (PNS). The purpose of this nested case-control study was to evaluate the relationship between lung cancer risk and external ionizing radiation exposure while adjusting for potential confounders that included gender, radiation monitoring status, smoking habit surrogates (socioeconomic status and birth cohort), welding fumes and asbestos. By incidence density sampling, we age-matched 3,291 controls selected from a cohort of 37,853 civilian workers employed at PNS between 1952 and 1992 with 1,097 lung cancer deaths from among the same cohort. Analyses using conditional logistic regression were conducted in various model forms: log-linear (main), linear excess relative risk (ERR), and categorical. Lung cancer risk was positively associated with occupational dose (OR = 1.02 at 10 mSv; 95% CI 0.99- 1.04) but flattened after the inclusion of work-related medical X-ray doses (OR = 1.00; 95% CI 0.98-1.03) in multivariate analyses. Similar risk estimates were observed in the linear ERR model at 10 mSv of cumulative exposure with a 15-year lag. JF - Radiation Research AU - Yiin, J H AU - Silver AU - Daniels, R D AU - Zaebst, D D AU - Seel, E A AU - Kubale, T L AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 341 EP - 348 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 168 IS - 3 SN - 0033-7587, 0033-7587 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Socioeconomics KW - Models KW - Smoking KW - Workers KW - Multivariate analysis KW - Regression analysis KW - Welding KW - Sampling KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Asbestos KW - Fumes KW - Cancer KW - Socio-economic aspects KW - Ionizing radiation KW - Gender KW - USA, New Hampshire, Portsmouth KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19714069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=A+Nested+Case-Control+Study+of+Lung+Cancer+Risk+and+Ionizing+Radiation+Exposure+at+the+Portsmouth+Naval+Shipyard&rft.au=Yiin%2C+J+H%3BSilver%3BDaniels%2C+R+D%3BZaebst%2C+D+D%3BSeel%2C+E+A%3BKubale%2C+T+L&rft.aulast=Yiin&rft.aufirst=J&rft.date=2007-09-01&rft.volume=168&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0843.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=168&issue=3&page=341 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Asbestos; Fumes; Models; Workers; Socio-economic aspects; Smoking; Multivariate analysis; Ionizing radiation; Regression analysis; Welding; Sampling; Occupational exposure; Lung cancer; Mortality; Gender; Socioeconomics; Cancer; USA, New Hampshire, Portsmouth DO - http://dx.doi.org/10.1667/RR0843.1 ER -