TY - JOUR T1 - Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide. AN - 70731391; 17345587 AB - The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg(-1) body weight) of colchicine (COL) was determined in young, mature male and female Sprague-Dawley rats. The effect of COL was evaluated in the presence or absence of additional treatment variables that included vehicle and lipopolysaccharide (LPS) pre-exposure. The vehicle for COL was either Half and Half cream (H & H) or saline, and each group included pretreatment with either saline or a low, minimally toxic dose (83 microg kg(-1) body weight) of LPS. Colchicine toxicity in both male and female age-matched rats was characterized by progressively more severe dose-related clinical signs of toxicity. These included mortality, decreased body weight and feed intake during the first several days after dosing, with recovery thereafter in surviving animals. There were differences in the severity of the toxic response to COL between male and female rats. The most notable sex-related difference was in COL lethality. Female rats were two times more susceptible to the lethal effects of COL than male rats. Saline or H & H delivery vehicles did not result in any apparent qualitative or quantitative differences in COL toxicity. LPS pretreatment significantly potentiated COL lethality in both males and females, although the potentiation in males was greater than in females. LPS pretreatment modestly increased the COL induced anorexic effect in surviving males, but not in surviving female animals. LPS did not appear to modulate either the body weights or clinical signs of COL induced toxicity in surviving males or females. (c) 2007 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Wiesenfeld, Paddy L AU - Garthoff, Larry H AU - Sobotka, Thomas J AU - Suagee, Jessica K AU - Barton, Curtis N AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, Neurotoxicity and In Vitro Toxicology Branch, Laurel, MD, USA. paddy.wiesenfeld@fda.hhs.gov PY - 2007 SP - 421 EP - 433 VL - 27 IS - 5 SN - 0260-437X, 0260-437X KW - Lipopolysaccharides KW - 0 KW - Pharmaceutical Vehicles KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Sex Factors KW - Body Weight -- drug effects KW - Lethal Dose 50 KW - Male KW - Female KW - Colchicine -- toxicity KW - Lipopolysaccharides -- toxicity KW - Colchicine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70731391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Acute+oral+toxicity+of+colchicine+in+rats%3A+effects+of+gender%2C+vehicle+matrix+and+pre-exposure+to+lipopolysaccharide.&rft.au=Wiesenfeld%2C+Paddy+L%3BGarthoff%2C+Larry+H%3BSobotka%2C+Thomas+J%3BSuagee%2C+Jessica+K%3BBarton%2C+Curtis+N&rft.aulast=Wiesenfeld&rft.aufirst=Paddy&rft.date=2007-09-01&rft.volume=27&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-25 N1 - Date created - 2007-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethical and scientific issues of nanotechnology in the workplace. AN - 70143533; 18813467 AB - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decision making about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the a) identification and communication of hazards and risks by scientists, authorities, and employers; b) workers' acceptance of risk; c) selection and implementation of controls; d) establishment of medical screening programs; and e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective. JF - Ciencia & saude coletiva AU - Schulte, Paul A AU - Salamanca-Buentello, Fabio AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. pschulte@cdc.gov PY - 2007 SP - 1319 EP - 1332 VL - 12 IS - 5 KW - Index Medicus KW - Humans KW - Risk Management KW - Workplace KW - Safety Management KW - Occupational Health KW - Nanotechnology -- ethics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70143533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ciencia+%26+saude+coletiva&rft.atitle=Ethical+and+scientific+issues+of+nanotechnology+in+the+workplace.&rft.au=Schulte%2C+Paul+A%3BSalamanca-Buentello%2C+Fabio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2007-09-01&rft.volume=12&rft.issue=5&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Ciencia+%26+saude+coletiva&rft.issn=1678-4561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-18 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Direct method for determination of Sudan I in FD&C Yellow No. 6 and D&C Orange No. 4 by reversed-phase liquid chromatography. AN - 68429174; 17955981 AB - A reversed-phase liquid chromatographic method was developed to determine parts-per-million and higher levels of Sudan 1, 1-(phenylazo)-2-naphthalenol, in the disulfo monoazo color additive FD&C Yellow No. 6 and in a related monosulfo monoazo color additive, D&C Orange No. 4. Sudan I, the corresponding unsulfonated monoazo dye, is a known impurity in these color additives. The color additives are dissolved in water and methanol, and the filtered solutions are directly chromatographed, without extraction or concentration, by using gradient elution at 0.25 mL/min. Calibrations from peak areas at 485 nm were linear. At a 99% confidence level, the limits of determination were 0.008 microg Sudan I/mL (0.4 ppm) in FD&C Yellow No. 6 and 0.011 microg Sudan I/mL (0.00011%) in D&C Orange No. 4. The confidence intervals were 0.202 +/- 0.002 microg Sudan I/mL (10.1 +/- 0.1 ppm) near the specification level for Sudan I in FD&C Yellow No. 6 and 20.0 +/- 0.2 microg Sudan I/mL (0.200 +/- 0.002%) near the highest concentration of Sudan I found in D&C Orange No. 4. A survey was conducted to determine Sudan I in 28 samples of FD&C Yellow No. 6 from 17 international manufacturers over 3 years, and in a pharmacology-tested sample. These samples were found to contain undetected levels (16 samples), 0.5-9.7 ppm Sudan I (0.01-0.194 microg Sudan I/mL in analyzed solutions; 11 samples including the pharmacology sample), and > or =10 ppm Sudan I (> or = 0.2 microg Sudan I/mL; 2 samples). Analyses of 21 samples of D&C Orange No. 4 from 8 international manufacturers over 4 years found Sudan I at undetected levels (8 samples), 0.0005 to < 0.005% Sudan I (0.05 to < 0.5 microg Sudan I/mL in analyzed solutions; 3 samples, including a pharmacology batch), 0.005 to <0.05% Sudan I (0.5 to <5 microg Sudan I/mL; 9 samples), and 0.18% Sudan I (18 microg Sudan I/mL; 1 sample). JF - Journal of AOAC International AU - Petigara, Bhakti R AU - Scher, Alan L AD - U.S. Food and Drug Administration, Office of Cosmetics and Colors, HFS-106, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. PY - 2007 SP - 1373 EP - 1378 VL - 90 IS - 5 SN - 1060-3271, 1060-3271 KW - Azo Compounds KW - 0 KW - Naphthols KW - C.I. Solvent Orange 2 KW - 2646-17-5 KW - 1-phenylazo-2-naphthol KW - 48I7IBB68J KW - FD & C Yellow No. 6 KW - H77VEI93A8 KW - Index Medicus KW - Reproducibility of Results KW - Spectrophotometry, Ultraviolet -- methods KW - Calibration KW - Models, Chemical KW - Time Factors KW - Naphthols -- analysis KW - Chromatography, Liquid -- methods KW - Technology, Pharmaceutical -- methods KW - Azo Compounds -- analysis KW - Chemistry, Pharmaceutical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68429174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Direct+method+for+determination+of+Sudan+I+in+FD%26amp%3BC+Yellow+No.+6+and+D%26amp%3BC+Orange+No.+4+by+reversed-phase+liquid+chromatography.&rft.au=Petigara%2C+Bhakti+R%3BScher%2C+Alan+L&rft.aulast=Petigara&rft.aufirst=Bhakti&rft.date=2007-09-01&rft.volume=90&rft.issue=5&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost. AN - 68426389; 17956716 AB - A 63-year-old man with a T1c adenocarcinoma of the prostate, Gleason score of 7 (4+3), and a pretreatment prostate-specific antigen (PSA) level of 9.5 ng/mL was treated with external-beam radiation therapy (45 Gy) and 2 magnetic resonance imaging-guided high-dose rate brachytherapy boosts (10 Gy each.) The patient also received neoadjuvant, concurrent, and adjuvant hormonal treatment with leuprolide for 7 months total. Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy. His PSA nadir was <0.2 ng/mL and rose slowly over several months to 4.2 ng/mL, resolved, and then rose 2.3 ng/mL before again slowly resolving. After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment. This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation. To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients. JF - Clinical genitourinary cancer AU - Mishra, Mark V AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 406 EP - 408 VL - 5 IS - 6 SN - 1558-7673, 1558-7673 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Leuprolide KW - EFY6W0M8TG KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Male KW - Magnetic Resonance Imaging KW - Adenocarcinoma -- blood KW - Radiotherapy, Conformal KW - Brachytherapy -- adverse effects KW - Prostatic Neoplasms -- blood KW - Prostate-Specific Antigen -- blood KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Prostatic Neoplasms -- radiotherapy KW - Adenocarcinoma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=A+second+transient+prostate-specific+antigen+elevation+after+external-beam+radiation+therapy+and+fractionated+magnetic+resonance+imaging-guided+high-dose+rate+brachytherapy+boost.&rft.au=Mishra%2C+Mark+V%3BSingh%2C+Anurag+K&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thymosin alpha1 as a chemopreventive agent in lung and breast cancer. AN - 68406532; 17567944 AB - The ability of thymosin alpha1 (Talpha1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg). Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines. These results suggest that Talpha1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Talpha1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU). The rat survival was significantly increased by the daily injection of Talpha1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1. These results indicate that Talpha1 is a chemopreventive agent in animal models for lung and breast carcinogenesis. JF - Annals of the New York Academy of Sciences AU - Moody, Terry W AD - Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. moodyt@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 297 EP - 304 VL - 1112 SN - 0077-8923, 0077-8923 KW - Anticarcinogenic Agents KW - 0 KW - Thymosin KW - 61512-21-8 KW - thymalfasin KW - W0B22ISQ1C KW - Index Medicus KW - Rats KW - Mice, Inbred A KW - Animals KW - Rats, Inbred F344 KW - Adenoma -- prevention & control KW - Mice KW - Female KW - Lung Neoplasms -- prevention & control KW - Anticarcinogenic Agents -- therapeutic use KW - Thymosin -- therapeutic use KW - Mammary Neoplasms, Animal -- prevention & control KW - Thymosin -- analogs & derivatives KW - Mammary Neoplasms, Animal -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68406532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Thymosin+alpha1+as+a+chemopreventive+agent+in+lung+and+breast+cancer.&rft.au=Moody%2C+Terry+W&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=1112&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. AN - 68327410; 17617661 AB - High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion. Modification of this relationship by host genetic factors is unknown. We investigated cruciferous vegetable intake in 1097 cases and 1555 controls enrolled in a multicentric case-control study from the Czech Republic, Poland, Romania and Russia. To assess possible gene-diet interactions, genotyped cases (N = 925) and controls (N = 1247) for selected functional or non-synonymous polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution. The odds ratio (OR) for low (less than once per month) versus high (at least once per week) intake of cruciferous vegetables was 1.29 [95% confidence interval (CI): 1.02-1.62; P-trend = 0.03]. When low intake of cruciferous vegetables (less than once per month) was stratified by GST genotype, higher kidney cancer risks were observed among individuals with the GSTT1 null (OR = 1.86; 95% CI: 1.07-3.23; P-interaction = 0.05) or with both GSTM1/T1 null genotypes (OR = 2.49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms. JF - Carcinogenesis AU - Moore, L E AU - Brennan, P AU - Karami, S AU - Hung, R J AU - Hsu, C AU - Boffetta, P AU - Toro, J AU - Zaridze, D AU - Janout, V AU - Bencko, V AU - Navratilova, M AU - Szeszenia-Dabrowska, N AU - Mates, D AU - Mukeria, A AU - Holcatova, I AU - Welch, R AU - Chanock, S AU - Rothman, N AU - Chow, W-H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorele@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1960 EP - 1964 VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - DNA KW - 9007-49-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Europe -- epidemiology KW - Feeding Behavior KW - Genotype KW - DNA -- isolation & purification KW - Europe, Eastern -- epidemiology KW - Risk Factors KW - DNA -- blood KW - Adult KW - DNA -- genetics KW - Interviews as Topic KW - Middle Aged KW - Male KW - Female KW - Sequence Deletion KW - Kidney Neoplasms -- genetics KW - Vegetables KW - Brassicaceae KW - Polymorphism, Genetic KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68327410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Glutathione+S-transferase+polymorphisms%2C+cruciferous+vegetable+intake+and+cancer+risk+in+the+Central+and+Eastern+European+Kidney+Cancer+Study.&rft.au=Moore%2C+L+E%3BBrennan%2C+P%3BKarami%2C+S%3BHung%2C+R+J%3BHsu%2C+C%3BBoffetta%2C+P%3BToro%2C+J%3BZaridze%2C+D%3BJanout%2C+V%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BMukeria%2C+A%3BHolcatova%2C+I%3BWelch%2C+R%3BChanock%2C+S%3BRothman%2C+N%3BChow%2C+W-H&rft.aulast=Moore&rft.aufirst=L&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1960&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update of US FDA's Total Diet Study food list and diets. AN - 68266183; 17410117 AB - The US Food and Drug Administration's (FDA) Total Diet Study (TDS) has been conducted continuously since the early 1960s to measures levels of various pesticide residues, contaminants, and nutrients in foods and to estimate the dietary exposures to these compounds. Both the TDS food list and the consumption amounts used for estimating exposures are based on results of nationwide food consumption surveys, and they are updated periodically to reflect changes in food consumption patterns. The most recent update was completed in 2003 using the same methodology employed in the previous update (1990). The updated food list includes approximately the same number of foods (285) as the previous list (290). Although most (75%) foods are the same in both versions, the new list reflects trends in consumption of foods containing less fat. The updated diets reflect an increase in total food consumption, with most notable increases in consumption of grains and beverages. A case study comparing cadmium exposures calculated from both the 1990 and 2003 versions of the TDS demonstrated the potential impact of changes in both the food list and consumption amounts on TDS exposure estimates. JF - Journal of exposure science & environmental epidemiology AU - Egan, Sara Kathleen AU - Bolger, Philip Michael AU - Carrington, Clark Dewitt AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740-3835, USA. Katie.Egan@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 573 EP - 582 VL - 17 IS - 6 SN - 1559-0631, 1559-0631 KW - Environmental Pollutants KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Index Medicus KW - United States KW - Cadmium -- analysis KW - Humans KW - Aged KW - Child KW - Environmental Pollutants -- analysis KW - Child, Preschool KW - Eating KW - Infant KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - United States Food and Drug Administration KW - Food KW - Food Contamination -- analysis KW - Diet Surveys KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68266183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Update+of+US+FDA%27s+Total+Diet+Study+food+list+and+diets.&rft.au=Egan%2C+Sara+Kathleen%3BBolger%2C+Philip+Michael%3BCarrington%2C+Clark+Dewitt&rft.aulast=Egan&rft.aufirst=Sara&rft.date=2007-09-01&rft.volume=17&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=15590631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal serum polychlorinated biphenyl concentrations across critical windows of human development. AN - 68241658; 17805422 AB - Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window. Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n = 10), at approximately 6 weeks postpartum (n = 53), and after 12 unsuccessful cycles (n = 9) for toxicologic analysis of 76 PCB congeners. We estimated overall and daily rate of change in PCB concentration (nanograms per gram serum) adjusting for relevant covariates, serum lipids, and baseline PCB concentration. Significant (p < 0.0001) decreases in the mean overall and daily rate of change in PCB concentrations were observed between the preconception and first pregnancy samples for total (-1.012 and -0.034, respectively), estrogenic (-0.444 and -0.016, respectively), and antiestrogenic (-0.106 and -0.004, respectively) PCBs among women with live births. Similar significant decreases in total (-1.452 and -0.085), estrogenic (-0.647 and -0.040), and antiestrogenic (-0.093 and -0.004) PCB concentrations were seen for women with pregnancy losses. No significant changes were observed for PCB congener 153. These data suggest that PCB concentrations may change during the periconception interval, questioning the stability of persistent compounds during this critical window. JF - Environmental health perspectives AU - Bloom, Michael S AU - Buck Louis, Germaine M AU - Schisterman, Enrique F AU - Liu, Aiyi AU - Kostyniak, Paul J AD - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1320 EP - 1324 VL - 115 IS - 9 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - critical windows KW - polychlorinated biphenyls (PCBs) KW - persistent organic pollutants KW - infertility KW - periconception KW - pregnancy loss KW - Infant KW - Embryonic Development KW - Postpartum Period -- blood KW - Humans KW - Adult KW - Child Development KW - Fetal Development KW - Female KW - Pregnancy KW - Polychlorinated Biphenyls -- blood KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68241658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Maternal+serum+polychlorinated+biphenyl+concentrations+across+critical+windows+of+human+development.&rft.au=Bloom%2C+Michael+S%3BBuck+Louis%2C+Germaine+M%3BSchisterman%2C+Enrique+F%3BLiu%2C+Aiyi%3BKostyniak%2C+Paul+J&rft.aulast=Bloom&rft.aufirst=Michael&rft.date=2007-09-01&rft.volume=115&rft.issue=9&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2000 Jul;11(4):388-93 [10874544] Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206] Environ Sci Technol. 2001 Feb 1;35(3):435-40 [11351711] Environ Res. 2001 Jun;86(2):128-39 [11437459] J Toxicol Environ Health A. 2001 Nov 23;64(6):485-98 [11732699] Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806] Environ Health Perspect. 2003 Mar;111(3):349-55 [12611665] Environ Health Perspect. 2003 Jul;111(9):1253-8 [12842782] Environ Health Perspect. 2004 Jan;112(1):69-78 [14698934] Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935] Environ Health Perspect. 2004 Feb;112(2):266-71 [14754582] Epidemiology. 2004 Sep;15(5):615-25 [15308962] Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694] Sci Total Environ. 1995 Jan 15;160-161:529-37 [7892583] Toxicol Ind Health. 1996 May-Aug;12(3-4):327-34 [8843550] Arch Environ Contam Toxicol. 1997 Apr;32(3):329-36 [9096084] Teratology. 1997 May;55(5):338-47 [9261928] J Anal Toxicol. 1997 Nov-Dec;21(7):558-66 [9399126] Arch Environ Health. 1999 Mar-Apr;54(2):110-4 [10094288] Environ Res. 1999 Feb;80(2 Pt 2):S166-S174 [10092430] Environ Res. 2005 Feb;97(2):134-41 [15533329] Environ Res. 2005 Feb;97(2):178-94 [15533334] Environ Health Perspect. 2005 Jul;113(7):853-7 [16002372] Environ Health. 2005;4:10 [15927085] Obstet Gynecol. 2001 May;97(5 Pt 1):669-72 [11339913] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Workgroup report: National Toxicology Program workshop on Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays. AN - 68239502; 17805427 AB - The National Toxicology Program (NTP) is currently reviewing its research portfolio as part of its efforts to implement the NTP Roadmap to achieve the NTP Vision for the 21st century. This review includes a recent workshop, "Hormonally Induced Reproductive Tumors-Relevance of Rodent Bioassays," held 22-24 May 2006, that was organized to determine the adequacy and relevance to human disease outcome of rodent models currently used in the 2-year bioassay for four types of hormonally induced reproductive tumors (ovary, mammary gland, prostate, and testis). In brief, none of the workshop's breakout groups felt the currently used models are sufficient. For some types of tumors such as prostate, no adequate animal models exist, and for others such as ovary, the predominant tumors in humans are of different cellular origins than those induced by chemicals in rodents. This inadequacy of current models also applies to the testis, although our more complete understanding of the responses of Leydig cells to hormonal changes in rats may prove predictive for effects in humans other than cancer. All breakout groups recommended that the NTP consider modifying its testing protocols (i.e., age at exposure, additional end points, etc.) and/or using alternative models (i.e., genetically engineered models, in vitro systems, etc.) to improve sensitivity. In this article we briefly review the workshop's outcome and outline some next steps forward in pursuing the workshop's recommendations. Breakout group reports and additional information on the workshop, including participants, presentations, public comments and background materials, are posted on the NTP website. JF - Environmental health perspectives AU - Thayer, Kristina A AU - Foster, Paul M AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1351 EP - 1356 VL - 115 IS - 9 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Hormones KW - Index Medicus KW - breast KW - prostate KW - species differences KW - ovary KW - reproductive tumors KW - National Toxicology Program KW - animal models KW - testis KW - endocrine KW - mammary gland KW - hormone KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Government Programs KW - Carcinogenicity Tests KW - Mice KW - Federal Government KW - Models, Animal KW - Urogenital Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Breast Neoplasms -- chemically induced KW - Hormones -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68239502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Workgroup+report%3A+National+Toxicology+Program+workshop+on+Hormonally+Induced+Reproductive+Tumors+-+Relevance+of+Rodent+Bioassays.&rft.au=Thayer%2C+Kristina+A%3BFoster%2C+Paul+M&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2007-09-01&rft.volume=115&rft.issue=9&rft.spage=1351&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):49-61 [10819504] Toxicol Pathol. 2006;34(6):802-5 [17162538] J Pathol. 2003 Mar;199(3):378-86 [12579540] Toxicol Sci. 2004 Oct;81(2):401-7 [15240895] Fundam Appl Toxicol. 1993 Aug;21(2):174-86 [8405780] Fundam Appl Toxicol. 1993 Nov;21(4):451-60 [8253298] Neoplasma. 1998;45(6):373-6 [10210111] Crit Rev Toxicol. 1999 Mar;29(2):169-261 [10213111] Toxicol Pathol. 2005;33(3):386-97 [15805078] J Appl Toxicol. 2005 Nov-Dec;25(6):514-21 [16158390] Prostate. 2006 Jan 1;66(1):57-69 [16114064] J Appl Toxicol. 2006 Jan-Feb;26(1):72-80 [16193534] Environ Health Perspect. 2006 Jun;114(6):A348-9 [16759971] Natl Toxicol Program Tech Rep Ser. 2006 Apr;(521):4-232 [16835633] Natl Toxicol Program Tech Rep Ser. 2006 May;(529):4-168 [16835634] Toxicol Pathol. 2001 Nov-Dec;29(6):639-52 [11794380] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of food for toxic elements. AN - 68196079; 17609933 AB - The levels of the toxic elements Al, As, Cd, Hg, Pb and Sn are routinely monitored in food to protect the consumer. Increasingly, the chemical forms of As and Hg are also monitored. Analyses are performed to enforce regulatory standards and to accumulate background levels for assessing long-term exposure. The analytical procedures used for these activities evolve as requirements to determine lower levels arise and as both the types and sheer number of different foods that need to be analyzed increase. This review highlights recent work addressing improvements in the analysis of toxic elements in food. The topics covered include contamination control, analytical sample treatment and the common analytical techniques used for food analysis. JF - Analytical and bioanalytical chemistry AU - Capar, Stephen G AU - Mindak, William R AU - Cheng, John AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W. Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA. stephen.capar@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 159 EP - 169 VL - 389 IS - 1 SN - 1618-2642, 1618-2642 KW - Hazardous Substances KW - 0 KW - Metals KW - Index Medicus KW - Hazardous Substances -- administration & dosage KW - Animals KW - Metals -- administration & dosage KW - Humans KW - Metals -- analysis KW - Hazardous Substances -- analysis KW - Food Analysis KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68196079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=International+Review+of+Social+History&rft.atitle=Book+Reviews%3A+Founding+an+Empire+on+India%27s+North-Eastern+Frontiers+1790-1840.+Climate%2C+Commerce%2C+Polity%3B+One+Hundred+Years+of+Servitude.+Political+Economy+of+Tea+Plantations+in+Colonial+Assam&rft.au=Rappaport%2C+Erika&rft.aulast=Rappaport&rft.aufirst=Erika&rft.date=2016-12-01&rft.volume=61&rft.issue=3&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=International+Review+of+Social+History&rft.issn=00208590&rft_id=info:doi/10.1017%2FS0020859016000560 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-17 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent studies on selected botanical dietary supplement ingredients. AN - 68195924; 17390125 AB - The market for botanical dietary supplements in the US has grown rapidly during the last 15 years. Use of newly introduced botanical ingredients has often outpaced an adequate scientific understanding of the ingredients themselves. This may lead to problems, including misidentification, mislabeling, adulteration, and toxicity related to the intended ingredient or one substituted for it. This article reviews recent work with several botanical ingredients (Ephedra, Citrus species, Hoodia gordonii, Teucrium, isoflavones) that illustrates the complexity of the current situation and approaches that contribute to ensuring the quality of botanical ingredients. Recent work with contamination of botanical products by mycotoxins is also reviewed. The need for tools for botanical authentication and methods for reproducible extraction of bioactive constituents is critical. Such tools, and improved analytical techniques for identifying potentially bioactive constituents in fresh plant material and in concentrated extracts and for detection of hazardous contaminants, are expected to improve the overall quality and safety of botanical dietary supplement ingredients. JF - Analytical and bioanalytical chemistry AU - Rader, Jeanne I AU - Delmonte, Pierluigi AU - Trucksess, Mary W AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Jeanne.Rader@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 27 EP - 35 VL - 389 IS - 1 SN - 1618-2642, 1618-2642 KW - Isoflavones KW - 0 KW - Mycotoxins KW - Plant Extracts KW - Index Medicus KW - Isoflavones -- analysis KW - Isoflavones -- chemistry KW - Mycotoxins -- chemistry KW - Mycotoxins -- analysis KW - Dietary Supplements -- standards KW - Plant Extracts -- chemistry KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68195924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=Recent+studies+on+selected+botanical+dietary+supplement+ingredients.&rft.au=Rader%2C+Jeanne+I%3BDelmonte%2C+Pierluigi%3BTrucksess%2C+Mary+W&rft.aulast=Rader&rft.aufirst=Jeanne&rft.date=2007-09-01&rft.volume=389&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=16182642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-17 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the catalytic metal during polymerization by DNA polymerase lambda. AN - 68177083; 17475573 AB - The incorporation of dNMPs into DNA by polymerases involves a phosphoryl transfer reaction hypothesized to require two divalent metal ions. Here we investigate this hypothesis using as a model human DNA polymerase lambda (Pol lambda), an enzyme suggested to be activated in vivo by manganese. We report the crystal structures of four complexes of human Pol lambda. In a 1.9 A structure of Pol lambda containing a 3'-OH and the non-hydrolyzable analog dUpnpp, a non-catalytic Na+ ion occupies the site for metal A and the ribose of the primer-terminal nucleotide is found in a conformation that positions the acceptor 3'-OH out of line with the alpha-phosphate and the bridging oxygen of the pyrophosphate leaving group. Soaking this crystal in MnCl2 yielded a 2.0 A structure with Mn2+ occupying the site for metal A. In the presence of Mn2+, the conformation of the ribose is C3'-endo and the 3'-oxygen is in line with the leaving oxygen, at a distance from the phosphorus atom of the alpha-phosphate (3.69 A) consistent with and supporting a catalytic mechanism involving two divalent metal ions. Finally, soaking with MnCl2 converted a pre-catalytic Pol lambda/Na+ complex with unreacted dCTP in the active site into a product complex via catalysis in the crystal. These data provide pre- and post-transition state information and outline in a single crystal the pathway for the phosphoryl transfer reaction carried out by DNA polymerases. JF - DNA repair AU - Garcia-Diaz, Miguel AU - Bebenek, Katarzyna AU - Krahn, Joseph M AU - Pedersen, Lars C AU - Kunkel, Thomas A AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 1333 EP - 1340 VL - 6 IS - 9 SN - 1568-7864, 1568-7864 KW - Phosphates KW - 0 KW - Manganese KW - 42Z2K6ZL8P KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Index Medicus KW - Phosphates -- metabolism KW - Crystallization KW - Models, Molecular KW - Humans KW - Crystallography, X-Ray KW - Protein Binding KW - Protein Conformation KW - Catalysis KW - Binding Sites KW - Manganese -- pharmacology KW - DNA Polymerase beta -- genetics KW - DNA -- metabolism KW - DNA Polymerase beta -- chemistry KW - DNA -- chemistry KW - DNA Polymerase beta -- metabolism KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Role+of+the+catalytic+metal+during+polymerization+by+DNA+polymerase+lambda.&rft.au=Garcia-Diaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKrahn%2C+Joseph+M%3BPedersen%2C+Lars+C%3BKunkel%2C+Thomas+A&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-25 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] Mol Cell. 2005 Aug 5;19(3):357-66 [16061182] Proteins. 2003 Feb 15;50(3):437-50 [12557186] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] Biochemistry. 2003 Aug 19;42(32):9564-74 [12911298] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766] Mol Cell. 2004 Feb 27;13(4):561-72 [14992725] Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109] J Biol Chem. 1972 Nov 10;247(21):6784-94 [4343158] J Biol Chem. 1979 Aug 10;254(15):6889-93 [378995] J Biol Chem. 1990 Aug 25;265(24):14327-34 [2201684] EMBO J. 1991 Jan;10(1):25-33 [1989886] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Mol Cell. 2004 Dec 3;16(5):701-13 [15574326] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] EMBO J. 2005 Sep 7;24(17):2957-67 [16107880] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Cell. 2006 Jan 27;124(2):331-42 [16439207] Mol Cell. 2006 Apr 7;22(1):5-13 [16600865] Structure. 2006 Apr;14(4):757-66 [16615916] Nucleic Acids Res. 2006;34(11):3259-66 [16807316] Immunity. 2006 Jul;25(1):31-41 [16860755] Radiat Res. 2006 Nov;166(5):693-714 [17067213] Annu Rev Biochem. 2002;71:133-63 [12045093] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute toxicity of sodium arsenite in a complex food matrix. AN - 68110374; 17418926 AB - Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0mg/kg As in deionized water (41 mg/kg As-water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41 mg/kg As-water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41 mg/kg As-water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410 mg/kg) was administered in HH however, at lower doses (41 mg/kg), HH reduced acute As oral toxicity in the female and developing fetus. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sprando, R L AU - Collins, T F X AU - Black, T AU - Olejnik, N AU - Ramos-Valle, M AU - Ruggles, D AD - Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Road, Laurel, MD 20708, United States. rsprando@cfsan.fda.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1606 EP - 1613 VL - 45 IS - 9 SN - 0278-6915, 0278-6915 KW - Arsenites KW - 0 KW - Dietary Fats KW - Enzyme Inhibitors KW - Sodium Compounds KW - Water KW - 059QF0KO0R KW - sodium arsenite KW - 48OVY2OC72 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Dose-Response Relationship, Drug KW - Fetal Resorption -- pathology KW - Gestational Age KW - Fetal Resorption -- chemically induced KW - Pregnancy KW - Rats KW - Rats, Sprague-Dawley KW - Survival Rate KW - Toxicity Tests, Acute KW - Water -- pharmacology KW - Female KW - Male KW - Dietary Fats -- pharmacology KW - Sodium Compounds -- administration & dosage KW - Fetus -- drug effects KW - Fetus -- embryology KW - Enzyme Inhibitors -- administration & dosage KW - Enzyme Inhibitors -- toxicity KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity KW - Food Contamination KW - Arsenites -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Acute+toxicity+of+sodium+arsenite+in+a+complex+food+matrix.&rft.au=Sprando%2C+R+L%3BCollins%2C+T+F+X%3BBlack%2C+T%3BOlejnik%2C+N%3BRamos-Valle%2C+M%3BRuggles%2C+D&rft.aulast=Sprando&rft.aufirst=R&rft.date=2007-09-01&rft.volume=45&rft.issue=9&rft.spage=1606&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-03 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Explaining Mental Health Treatment Disparities: Ethnic and Cultural Differences in Family Involvement AN - 61682748; 200806506 AB - In a large, representative sample of persons receiving public mental health treatment, we examined whether ethnic minority consumers were more likely than white consumers to live with their families and to receive family support. We then evaluated whether differences observed in family involvement explained treatment disparities observed in outpatient and inpatient mental health services. Results indicated that Asian American and Latino consumers, especially, were considerably more likely than white consumers to live with family members and to receive family support. Ethnocultural differences in living with family did explain treatment intensity disparities whether or not consumers described themselves as dependent on family support. The results support the hypothesis that cultural differences in family involvement and support play a role in explaining mental health treatment disparities. Adapted from the source document. JF - Culture, Medicine and Psychiatry AU - Snowden, Lonnie R AD - Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley, Berkeley, CA 94720, USA snowden@berkeley.edu Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 389 EP - 402 PB - Springer, Dordrecht The Netherlands VL - 31 IS - 3 SN - 0165-005X, 0165-005X KW - Minority Groups KW - Ethnic Groups KW - Sociocultural Factors KW - Family Life KW - Racial Differences KW - Mental Health Services KW - Treatment KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Culture%2C+Medicine+and+Psychiatry&rft.atitle=Explaining+Mental+Health+Treatment+Disparities%3A+Ethnic+and+Cultural+Differences+in+Family+Involvement&rft.au=Snowden%2C+Lonnie+R&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2007-09-01&rft.volume=31&rft.issue=3&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Culture%2C+Medicine+and+Psychiatry&rft.issn=0165005X&rft_id=info:doi/10.1007%2Fs11013-007-9057-z LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Number of references - 25 N1 - Last updated - 2016-09-28 N1 - CODEN - CMPSD2 N1 - SubjectsTermNotLitGenreText - Mental Health Services; Treatment; Racial Differences; Family Life; Sociocultural Factors; Ethnic Groups; Minority Groups DO - http://dx.doi.org/10.1007/s11013-007-9057-z ER - TY - JOUR T1 - Evolution of the Special Projects of National Significance Prevention with HIV-Infected Persons Seen in Primary Care Settings Initiative AN - 61408497; 200802102 AB - Abstract not available. JF - AIDS and Behavior AU - Malitz, Faye E AU - Eldred, Lois AD - HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, USA fmalitz@hrsa.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1 EP - 5 PB - Springer, Dordrecht, The Netherlands VL - 11 IS - Supplement 1 SN - 1090-7165, 1090-7165 KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Health Care Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61408497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Evolution+of+the+Special+Projects+of+National+Significance+Prevention+with+HIV-Infected+Persons+Seen+in+Primary+Care+Settings+Initiative&rft.au=Malitz%2C+Faye+E%3BEldred%2C+Lois&rft.aulast=Malitz&rft.aufirst=Faye&rft.date=2007-09-01&rft.volume=11&rft.issue=Supplement+1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-007-9252-5 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-04-02 N1 - Number of references - 22 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Prevention; Health Care Services; Acquired Immune Deficiency Syndrome DO - http://dx.doi.org/10.1007/s10461-007-9252-5 ER - TY - JOUR T1 - Pediatrician Perspectives on Children's Access to Mental Health Services: Consequences and Potential Solutions AN - 57099212; 200802866 AB - This paper examines pediatricians' perspectives regarding access to children's mental health care. In response to a question about factors that help or hinder coordination of care 190 respondents voluminously wrote about mental health access barriers. Responses were qualitatively analyzed to understand pediatricians' perspectives. Four thematic areas emerged: Insurance issues, availability of mental health specialty providers, state mental health systems, and pediatricians' attempts to improve access to mental health services. Pediatricians' responses included educating themselves, using telemedicine, and hiring co-located mental health specialists. Recommendations are made to address pediatricians' treatment of children with mental illnesses and their access to treatment resources. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Pfefferle, Susan G AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, 4 Brookings Dr., Campus Box 1093, St. Louis, MO 63130, USA spfefferle@gwbmail.wustl.edu Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 425 EP - 434 PB - Springer, Dordrecht The Netherlands VL - 34 IS - 5 SN - 0894-587X, 0894-587X KW - Child and adolescent mental health, Mental health policy, Pediatrics, Access KW - Mental health services KW - Health insurance KW - Health policy KW - Access KW - Paediatricians KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57099212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Pediatrician+Perspectives+on+Children%27s+Access+to+Mental+Health+Services%3A+Consequences+and+Potential+Solutions&rft.au=Pfefferle%2C+Susan+G&rft.aulast=Pfefferle&rft.aufirst=Susan&rft.date=2007-09-01&rft.volume=34&rft.issue=5&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0122-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Paediatricians; Mental health services; Access; Health insurance; Children; Health policy DO - http://dx.doi.org/10.1007/s10488-007-0122-2 ER - TY - JOUR T1 - Numerical analysis of the influence of in-seam horizontal methane drainage boreholes on longwall face emission rates AN - 51232140; 2008-075295 AB - High methane emissions originating from the active face areas and from the fractured formations overlying and underlying the mined coalbed can adversely affect both safety and productivity in underground coal mines. Since ventilation alone may not be sufficient to control the methane levels in the longwall mining environment, gob gas ventholes have become a standard supplementary methane control option in many mines. As mines progress into deeper and gassier coalbeds, or as longwall panel size increases, ventilation and gob gas ventholes together may not be sufficient to maintain methane levels within statutory limits. To decrease the risk associated with methane emissions under these circumstances, in-seam horizontal methane drainage is often used to reduce the gas content of the coalbed prior to mining. Horizontal methane drainage borehole completion designs, drilling strategies, and degasification lead times may need to be adjusted for site-specific conditions due to mine design, geology, and the gas content of the coalbed. This study investigates different horizontal methane drainage borehole patterns, borehole lengths, and degasification times prior to and during panel extraction to evaluate their effectiveness in reducing methane emissions using a "dynamic" 3D reservoir modeling of a 381-m wide longwall panel operating in the Pittsburgh coalbed. Results of this study showed that dual and tri-lateral boreholes are more effective in decreasing emissions and in shielding the entries compared to fewer shorter, cross-panel, horizontal boreholes parallel to the longwall face. Modeling results showed that after 12 months of pre-mining methane drainage, the average longwall face emission rates can be reduced by as much as 10.3 m (super 3) /min and 6.8 m (super 3) /min using tri- and dual-lateral boreholes, respectively. It was also shown that if pre-mining methane drainage time is short, it is important to continue methane drainage during the panel extraction to maximize reductions in longwall face emissions since additional face emission reductions achieved during this period can be comparable to pre-mining degasification. JF - International Journal of Coal Geology AU - Karacan, C O AU - Diamond, W P AU - Schatzel, S J Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 15 EP - 32 PB - Elsevier, Amsterdam VL - 72 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - mines KW - degasification KW - underground mining KW - numerical analysis KW - natural gas KW - drainage KW - data processing KW - coal mines KW - petroleum KW - coal seams KW - preventive measures KW - safety KW - longwall mining KW - boreholes KW - mining geology KW - digital simulation KW - coalbed methane KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51232140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Numerical+analysis+of+the+influence+of+in-seam+horizontal+methane+drainage+boreholes+on+longwall+face+emission+rates&rft.au=Karacan%2C+C+O%3BDiamond%2C+W+P%3BSchatzel%2C+S+J&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-09-01&rft.volume=72&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2006.12.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 29 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - boreholes; coal mines; coal seams; coalbed methane; data processing; degasification; digital simulation; drainage; longwall mining; mines; mining; mining geology; natural gas; numerical analysis; petroleum; preventive measures; safety; underground mining DO - http://dx.doi.org/10.1016/j.coal.2006.12.007 ER - TY - CPAPER T1 - Universal Virus Detection. T2 - 3rd European Congress of Virology AN - 39558919; 4649857 JF - 3rd European Congress of Virology AU - Uhlenhaut, Christine AU - Nanda, Santosh AU - Sierra-Honigmann, Ana AU - Krause, Philip R Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 KW - Polymerase chain reaction KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Universal+Virus+Detection.&rft.au=Uhlenhaut%2C+Christine%3BNanda%2C+Santosh%3BSierra-Honigmann%2C+Ana%3BKrause%2C+Philip+R&rft.aulast=Uhlenhaut&rft.aufirst=Christine&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology.org/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of EBV Encoded microRNA Abrogates Viral Infection. T2 - 3rd European Congress of Virology AN - 39449225; 4649724 JF - 3rd European Congress of Virology AU - Avni, Yonat Shemer AU - Keren-Naus, Ayelet AU - Tsurumi, Tatsuya AU - Ayzenberg, Natalie AU - Meiri, Eti AU - Barda, Einat AU - Bentwich, Zvi Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 KW - Infection KW - MiRNA KW - Viral diseases KW - Epstein-Barr virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39449225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Suppression+of+EBV+Encoded+microRNA+Abrogates+Viral+Infection.&rft.au=Avni%2C+Yonat+Shemer%3BKeren-Naus%2C+Ayelet%3BTsurumi%2C+Tatsuya%3BAyzenberg%2C+Natalie%3BMeiri%2C+Eti%3BBarda%2C+Einat%3BBentwich%2C+Zvi&rft.aulast=Avni&rft.aufirst=Yonat&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology.org/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of different Vaccination Schedules on the Excretion and Reversion of Attenuated Poliovirus. T2 - 3rd European Congress of Virology AN - 39411896; 4650110 JF - 3rd European Congress of Virology AU - Laassri, Majid AU - Lottenbach, Kathleen AU - Belshe, Robert AU - Plotkin, Stanley AU - Chumakov, Konstantin Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 KW - Excretion KW - Vaccination KW - Reversion KW - Poliovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39411896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Effect+of+different+Vaccination+Schedules+on+the+Excretion+and+Reversion+of+Attenuated+Poliovirus.&rft.au=Laassri%2C+Majid%3BLottenbach%2C+Kathleen%3BBelshe%2C+Robert%3BPlotkin%2C+Stanley%3BChumakov%2C+Konstantin&rft.aulast=Laassri&rft.aufirst=Majid&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology.org/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Infections and human tissue transplants: review of FDA MedWatch reports 2001-2004 AN - 20725522; 8310675 AB - Background: More than 1.5 million tissue allografts are transplanted annually in the U.S. As part of the federal effort to improve tissue safety, FDA's May 2005 Current Good Tissue Practices (CGTP) Rule requires tissue establishments to report to FDA serious infectious adverse events following allograft transplantation. To provide baseline data, we summarize reports of such infections received by FDA prior to the CGTP Rule. Methods: We reviewed reports received by FDA's MedWatch adverse event reporting system during 2001-2004. Our case definition was a reported infection in a human tissue transplant recipient within 1 year of transplantation. We examined demographics, tissue type, clinical outcomes and interventions, infectious organism(s), time from transplant to infection and reporter characteristics. Results: We identified 83 reports of infections following allograft transplantations. Median patient age was 40 years (range: 1 month-87 years). The allografts included heart valves (42%), tendons (33%), bones (8%), blood vessels (6%), ocular tissues (5%), and skin (4%). Commonly reported outcomes and interventions were hospitalization (72%), antibiotic therapy (46%) and graft removal (42%). Nine of 11 patients who expired had received heart valves. In 65 reports that identified suspected organisms, bacteria were most common (42), followed by fungi (25) and prions (1). The median time from transplant to infection was 5.5 weeks (range: 3 days-52 weeks). Tissue manufacturers submitted 26% of reports. Among the remaining 74%, the reporters were quality assurance staff, infection control or risk management personnel (45%); physicians (15%); consumers (15%); nurses (13%); and surgical staff (12%). Conclusion: This is the first review of reports to FDA for infections following allograft tissue transplantations. Infections led to serious outcomes and involved many tissue types. Although we were unable to confirm that reported infections were caused by the suspected tissue product, required reporting by tissue establishments and improvements in adverse event investigation will help to improve tissue safety surveillance. JF - Cell and Tissue Banking AU - Wang, Su AU - Zinderman, Craig AU - Wise, Robert AU - Braun, Miles AD - U.S. Food and Drug Administration/Center for Biologics Evaluation and Research/Office of Biostatistics and Epidemiology, 1401 Rockville Pike, Rockville, MD, 20852, USA, Craig.zinderman@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 211 EP - 219 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 8 IS - 3 SN - 1389-9333, 1389-9333 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Heart KW - Age KW - Skin KW - Data processing KW - Fungi KW - Heart transplantation KW - Antibiotics KW - Infection KW - Demography KW - Bone KW - Blood vessels KW - Personnel KW - Reviews KW - Quality control KW - Prion protein KW - Consumers KW - Tendons KW - K 03400:Human Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+and+Tissue+Banking&rft.atitle=Infections+and+human+tissue+transplants%3A+review+of+FDA+MedWatch+reports+2001-2004&rft.au=Wang%2C+Su%3BZinderman%2C+Craig%3BWise%2C+Robert%3BBraun%2C+Miles&rft.aulast=Wang&rft.aufirst=Su&rft.date=2007-09-01&rft.volume=8&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Cell+and+Tissue+Banking&rft.issn=13899333&rft_id=info:doi/10.1007%2Fs10561-007-9034-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Age; Data processing; Skin; Fungi; Heart transplantation; Antibiotics; Infection; Bone; Demography; Blood vessels; Personnel; Quality control; Reviews; Prion protein; Consumers; Tendons DO - http://dx.doi.org/10.1007/s10561-007-9034-3 ER - TY - JOUR T1 - Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk AN - 20723319; 7554738 AB - Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p sub(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters ( less than or equal to 4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of greater than or equal to 35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology. JF - American Journal of Epidemiology AU - Lim, Unhee AU - Morton, Lindsay M AU - Subar, Amy F AU - Baris, Dalsu AU - Stolzenberg-Solomon, Rachael AU - Leitzmann, Michael AU - Kipnis, Victor AU - Mouw, Traci AU - Carroll, Leslie AU - Schatzkin, Arthur AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 697 EP - 708 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Hodgkin's disease KW - obesity KW - body size KW - Non-Hodgkin's lymphoma KW - body mass KW - Risk factors KW - Cigarette smoking KW - Body size KW - Consumers KW - Ethanol KW - Diets KW - Alcohol KW - Inventories KW - Obesity KW - Etiology KW - Beverages KW - Data processing KW - Cancer KW - Body mass index KW - lymphoma KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol%2C+Smoking%2C+and+Body+Size+in+Relation+to+Incident+Hodgkin%27s+and+Non-Hodgkin%27s+Lymphoma+Risk&rft.au=Lim%2C+Unhee%3BMorton%2C+Lindsay+M%3BSubar%2C+Amy+F%3BBaris%2C+Dalsu%3BStolzenberg-Solomon%2C+Rachael%3BLeitzmann%2C+Michael%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BCarroll%2C+Leslie%3BSchatzkin%2C+Arthur%3BHartge%2C+Patricia&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2007-09-01&rft.volume=166&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Risk assessment; Obesity; Inventories; Etiology; Data processing; Hodgkin's disease; Beverages; Cancer; Non-Hodgkin's lymphoma; Risk factors; Cigarette smoking; Body size; Consumers; Body mass index; Ethanol; non-Hodgkin's lymphoma; Alcohol; body mass; obesity; body size; lymphoma ER - TY - JOUR T1 - Emergence of a Virulent Clade of Vibrio vulnificus and Correlation with the Presence of a 33-Kilobase Genomic Island AN - 20614316; 7554105 AB - Vibrio vulnificus is a ubiquitous inhabitant of the marine coastal environment, and an important pathogen of humans. We characterized a globally distributed sample of environmental isolates from a range of habitats and hosts and compared these with isolates recovered from cases of human infection. Multilocus sequence typing data using six housekeeping genes divided 63 of the 67 isolates into the two main lineages previously noted for this species, and this division was also confirmed using the 16S rRNA and open reading frame VV0401 markers. Lineage I was comprised exclusively of biotype 1 isolates, whereas lineage II contained biotype 1 and all biotype 2 isolates. Four isolates did not cluster within either lineage: two biotype 3 and two biotype 1 isolates. The proportion of isolates recovered from a clinical setting was noted to be higher in lineage I than in lineage II. Lineage I isolates were also associated with a 33-kb genomic island (region XII), one of three regions identified by genome comparisons as unique to the species. Region XII contained an arylsulfatase gene cluster, a sulfate reduction system, two chondroitinase genes, and an oligopeptide ABC transport system, all of which are absent from the majority of lineage II isolates. Arylsulfatases and the sulfate reduction system, along with performing a scavenging role, have been hypothesized to play a role in pathogenic processes in other bacteria. Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both. JF - Applied and Environmental Microbiology AU - Cohen, Ana Luisa V AU - Oliver, James D AU - DePaola, Angelo AU - Feil, Edward J AU - Fidelma Boyd, E AD - Department of Biological Sciences, University of Delaware, Newark, Delaware 19716. Department of Microbiology, National University of Ireland, Cork, Ireland. Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223. Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528. Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 5553 EP - 5565 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 73 IS - 17 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Genomes KW - Marine KW - Biotypes KW - Coastal environments KW - Pathogenic bacteria KW - Sulfate reduction KW - Bacterial diseases KW - Arylsulfatase KW - Pathogens KW - Infection KW - Habitat KW - Aquatic environment KW - multilocus sequence typing KW - Public health KW - Coastal zone KW - Vibrio vulnificus KW - Microorganisms KW - genomics KW - Oligopeptides KW - rRNA 16S KW - Open reading frames KW - J 02310:Genetics & Taxonomy KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20614316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Emergence+of+a+Virulent+Clade+of+Vibrio+vulnificus+and+Correlation+with+the+Presence+of+a+33-Kilobase+Genomic+Island&rft.au=Cohen%2C+Ana+Luisa+V%3BOliver%2C+James+D%3BDePaola%2C+Angelo%3BFeil%2C+Edward+J%3BFidelma+Boyd%2C+E&rft.aulast=Cohen&rft.aufirst=Ana+Luisa&rft.date=2007-09-01&rft.volume=73&rft.issue=17&rft.spage=5553&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Genomes; Coastal zone; Pathogenic bacteria; Bacterial diseases; Microorganisms; Public health; Biotypes; Coastal environments; Sulfate reduction; Arylsulfatase; Pathogens; Habitat; Infection; Aquatic environment; multilocus sequence typing; genomics; rRNA 16S; Oligopeptides; Open reading frames; Vibrio vulnificus; Marine ER - TY - JOUR T1 - Regional Differences in African Americans' High Risk for Stroke: The Remarkable Burden of Stroke for Southern African Americans AN - 20561267; 9271085 AB - Purpose The stroke mortality rate for African Americans aged 45 to 64 years is 3 to 4 times higher than for whites of the same age, with a decreasing black-to-white mortality ratio with increasing age. There is also a 'STROKE BELT' with higher stroke mortality in the southeastern United States. This study assesses if there are also geographic variations in the magnitude of the excess stroke mortality for African Americans. Methods The age- and sex-specific black-to-white mortality ratio was calculated for each of 26 states with a sufficient African American population for stable estimates. The southern excess was calculated as the percentage excess of southern over nonsouthern rates. Results Across age and sex strata, the black-to-white stroke mortality ratio was consistently higher for southern states, with an average black-to-white stroke mortality ratio that ranged from 6% to 21% higher among southern states than in nonsouthern states. Conclusions The increase in stroke mortality rates for African Americans in southern states is even larger than expected. That southern states that are not part of the 'STROKE BELT' (Virginia and Florida) also have an elevated black-to-white mortality ratio suggests the mechanism of higher risk for African Americans may be independent of the causes contributing to 'STROKE BELT.' Key Words: Cerebrovascular Accident; Mortality; Continental Population Groups; African Americans; Geography JF - Annals of Epidemiology AU - Howard, George AU - Labarthe, Darwin R AU - Hu, Jianfang AU - Yoon, Sarah AU - Howard, Virginia J AD - From the University of Alabama School of Public Health, Departments of Biostatistics (G.H., J.H.) and Epidemiology (V.J.H.), Birmingham; and the Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA (D.R.L., S.Y.), ghoward@uab.edu Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 689 EP - 696 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 9 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - stroke KW - Mortality KW - Age KW - Accidents KW - USA, Florida KW - Africa KW - USA, Virginia KW - USA, Southeast KW - Geography KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Regional+Differences+in+African+Americans%27+High+Risk+for+Stroke%3A+The+Remarkable+Burden+of+Stroke+for+Southern+African+Americans&rft.au=Howard%2C+George%3BLabarthe%2C+Darwin+R%3BHu%2C+Jianfang%3BYoon%2C+Sarah%3BHoward%2C+Virginia+J&rft.aulast=Howard&rft.aufirst=George&rft.date=2007-09-01&rft.volume=17&rft.issue=9&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; stroke; Accidents; Age; Geography; Ethnic groups; USA, Florida; Africa; USA, Virginia; USA, Southeast ER - TY - JOUR T1 - Relative and Combined Performance of Mammography and Ultrasonography for Breast Cancer Screening in the General Population: a Pilot Study in Tochigi Prefecture, Japan AN - 20404967; 7743412 AB - BACKGROUND: Breast cancer screening by mammography is thought to be effective in reducing breast cancer mortality while ultrasonography is not accepted as a population screening modality, although the latter has been suggested to be useful in detection of cancer in the dense breast, relatively more typical for a younger woman. METHODS: Mammography with medio-lateral oblique view was offered on trial in 1999-2000 for 3453 female residents in Tochigi prefecture who also underwent clinical breast examination and ultrasonography. The municipalities that provided cancer screening were informed of the final diagnosis for women with positive findings in the screening trial by doctors who performed the diagnostic evaluation. Linkage was also made between the list of participants in the trial and registrations at Tochigi Cancer Registry for breast cancer cases diagnosed during 1999-2001. RESULTS: Thirteen cases with breast cancer were identified during a 2-year follow-up period: 10 were diagnosed subsequent to positive finding in the trial; two were negative in the trial and diagnosed 23 and 24 months after, respectively; and one had a positive finding at the trial but was undiagnosed at first and then diagnosed 18 months after the trial. Among the 11 cases judged as positive in the trial, four were judged only by mammography while three were judged only by ultrasonography. Those mammography alone-detected cases were relatively young, at 36, 40, 47 and 54 years of age, respectively, while the ultrasonography alone-detected cases were aged 50, 55 and 68, respectively. CONCLUSIONS: Combined screening with mammography and ultrasonography may be feasible. A larger study is required to evaluate relative performance of mammography and ultrasonography in detail by characteristics of examinees and their breasts. JF - Japanese Journal of Clinical Oncology AU - Honjo, Satoshi AU - Ando, Jiro AU - Tsukioka, Takeo AU - Morikubo, Hiroshi AU - Ichimura, Miyuki AU - Sunagawa, Masakatsu AU - Hasegawa, Toshihiko AU - Watanabe, Teruki AU - Kodama, Tetsuro AU - Tominaga, Keigo AU - Sasagawa, Michizo AU - Koyama, Yasuo AD - Epidemiology Unit, Research Institute, Tochigi Cancer Center. Pediatrics Unit, Oomuta National Hospital, Omuta, Fukuoka. Department of Surgery. Department of Diagnostic Imaging, Tochigi Cancer Center. Medical Director. Department of Health Checkup and Examination, Tochigi Public Health Service Association. First Department of Surgery, Dokkyo Medical College, Shimotsuga-gun, Tochigi. Tochigi National Hospital, Utsunomiya. Health Promotion Division, Tochigi Prefectural Government, Utsunomiya. Tochigi Public Health Service Association, Utsunomiya. Tochigi Cancer Center, Utsunomiya, Japan Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 715 EP - 720 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 37 IS - 9 SN - 0368-2811, 0368-2811 KW - Biotechnology and Bioengineering Abstracts KW - Mortality KW - Age KW - Mammography KW - Population studies KW - Breast cancer KW - Ultrasonography KW - Clinical trials KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20404967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+Journal+of+Clinical+Oncology&rft.atitle=Relative+and+Combined+Performance+of+Mammography+and+Ultrasonography+for+Breast+Cancer+Screening+in+the+General+Population%3A+a+Pilot+Study+in+Tochigi+Prefecture%2C+Japan&rft.au=Honjo%2C+Satoshi%3BAndo%2C+Jiro%3BTsukioka%2C+Takeo%3BMorikubo%2C+Hiroshi%3BIchimura%2C+Miyuki%3BSunagawa%2C+Masakatsu%3BHasegawa%2C+Toshihiko%3BWatanabe%2C+Teruki%3BKodama%2C+Tetsuro%3BTominaga%2C+Keigo%3BSasagawa%2C+Michizo%3BKoyama%2C+Yasuo&rft.aulast=Honjo&rft.aufirst=Satoshi&rft.date=2007-09-01&rft.volume=37&rft.issue=9&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=Japanese+Journal+of+Clinical+Oncology&rft.issn=03682811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clinical trials; Mammography; Ultrasonography; Breast cancer; Mortality; Population studies; Age ER - TY - JOUR T1 - Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary AN - 20332449; 7610337 AB - Prenatal factors have been hypothesized to influence subsequent breast cancer development. Directly evaluating the associations of in utero exposures with risk, however, presents several methodologic and theoretical challenges, including the long induction period between exposure and disease and the lack of certainty regarding the critical timing of exposure. Indirect evaluation of these associations has been achieved by use of proxies such as gestational and neonatal characteristics. Evidence suggests that preeclampsia is associated with a reduced breast cancer risk, whereas high birth weight and dizygotic twinning seem associated with an increased risk. Asians born in Asia have substantially lower breast cancer risks than women born in the West. Although data thus far are few, what exists is not consistent with a unifying hypothesis for a particular biological exposure (such as estrogens or androgens) during pregnancy as mediating the observed associations between pregnancy factors and breast cancer risk. This suggests that additional studies of prenatal factors should seek to broaden the range of hormones, growth, and other endocrine factors that are evaluated in utero. Once candidate biomarkers are identified, assessing them with respect to breast cancer and with intermediate end points in carcinogenesis should be a priority. In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life. (Cancer Epidemiol Biomarkers Prev 2007; 16(9):1700-12) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Troisi, Rebecca AU - Potischman, Nancy AU - Hoover, Robert N AD - Divisions of Cancer Epidemiology and Genetics and Cancer Control and Population Science, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1700 EP - 1712 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 9 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - Prenatal experience KW - Hormones KW - Pregnancy KW - Reviews KW - Carcinogenesis KW - prevention KW - Breast cancer KW - birth weight KW - Asia KW - Metabolism KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20332449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Exploring+the+Underlying+Hormonal+Mechanisms+of+Prenatal+Risk+Factors+for+Breast+Cancer%3A+A+Review+and+Commentary&rft.au=Troisi%2C+Rebecca%3BPotischman%2C+Nancy%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-09-01&rft.volume=16&rft.issue=9&rft.spage=1700&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bioindicators; Prenatal experience; Reviews; Carcinogenesis; prevention; birth weight; Breast cancer; Hormones; Metabolism; estrogens; Pregnancy; Asia ER - TY - JOUR T1 - Development of a Multiplex Real-Time PCR Assay with an Internal Amplification Control for the Detection of Total and Pathogenic Vibrio parahaemolyticus Bacteria in Oysters AN - 20001590; 7608105 AB - Vibrio parahaemolyticus is an estuarine bacterium that is the leading cause of shellfish-associated cases of bacterial gastroenteritis in the United States. Our laboratory developed a real-time multiplex PCR assay for the simultaneous detection of the thermolabile hemolysin (tlh), thermostable direct hemolysin (tdh), and thermostable-related hemolysin (trh) genes of V. parahaemolyticus. The tlh gene is a species-specific marker, while the tdh and trh genes are pathogenicity markers. An internal amplification control (IAC) was incorporated to ensure PCR integrity and eliminate false-negative reporting. The assay was tested for specificity against >150 strains representing eight bacterial species. Only V. parahaemolyticus strains possessing the appropriate target genes generated a fluorescent signal, except for a late tdh signal generated by three strains of V. hollisae. The multiplex assay detected 10 super(4) CFU/reaction of total V. parahaemolyticus bacteria. The real-time PCR assay was utilized with a most-probable-number format, and its results were compared to standard V. parahaemolyticus isolation methodology during an environmental survey of Alaskan oysters. The IAC was occasionally inhibited by the oyster matrix, and this usually corresponded to negative results for V. parahaemolyticus targets. V. parahaemolyticus tlh, tdh, and trh were detected in 44, 44, and 52% of the oyster samples, respectively. V. parahaemolyticus was isolated from 33% of the samples, and tdh super(+) and trh super(+) strains were isolated from 19 and 26%, respectively. These results demonstrate the utility of the real-time PCR assay in environmental surveys and its possible application to outbreak investigations for the detection of total and pathogenic V. parahaemolyticus. JF - Applied and Environmental Microbiology AU - Nordstrom, Jessica L AU - Vickery, Michael CL AU - Blackstone, George M AU - Murray, Shelley L AU - DePaola, Angelo AD - Gulf Coast Seafood Laboratory, Division of Seafood Science and Technology, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528. Alaska Department of Environmental Conservation, Anchorage, Alaska 99501 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 5840 EP - 5847 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 73 IS - 18 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; ASFA Marine Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources KW - Pathogenic bacteria KW - Nucleotide sequence KW - Estuaries KW - Brackish KW - tlh gene KW - Pathogenicity KW - Vibrio parahaemolyticus KW - Colony-forming cells KW - DNA KW - Polymerase chain reaction KW - Marine molluscs KW - Shellfish KW - Disease detection KW - Gastroenteritis KW - Hemolysins KW - Environmental surveys KW - Q1 08484:Species interactions: parasites and diseases KW - Q4 27700:Molecular Techniques KW - A 01300:Methods KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Development+of+a+Multiplex+Real-Time+PCR+Assay+with+an+Internal+Amplification+Control+for+the+Detection+of+Total+and+Pathogenic+Vibrio+parahaemolyticus+Bacteria+in+Oysters&rft.au=Nordstrom%2C+Jessica+L%3BVickery%2C+Michael+CL%3BBlackstone%2C+George+M%3BMurray%2C+Shelley+L%3BDePaola%2C+Angelo&rft.aulast=Nordstrom&rft.aufirst=Jessica&rft.date=2007-09-01&rft.volume=73&rft.issue=18&rft.spage=5840&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Nucleotide sequence; Estuaries; DNA; Marine molluscs; Polymerase chain reaction; Shellfish; Disease detection; tlh gene; Pathogenicity; Colony-forming cells; Gastroenteritis; Hemolysins; Environmental surveys; Vibrio parahaemolyticus; Brackish ER - TY - JOUR T1 - Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development AN - 19909906; 8768007 AB - The concept of correlating pharmacokinetic parameters with body weight (termed as pharmacokinetic interspecies scaling) from different animal species has become a useful tool in drug development. Interspecies scaling is based on the power function, where the body weight of the species is plotted against the pharmacokinetic parameter of interest. Clearance, volume of distribution, and elimination half-life are the three most frequently extrapolated pharmacokinetic parameters. The predicted pharmacokinetic parameter clearance can be used for estimating a first-in-human dose. Over the years, many approaches have been suggested to improve the prediction of aforementioned pharmacokinetic parameters in humans from animal data. A literature review indicates that there are different degrees of success with different methods for different drugs. Interspecies scaling is also a very useful tool in veterinary medicine. The knowledge of pharmacokinetics in veterinary medicine is important for dosage selection, particularly in the treatment of large animals such as horses, camels, elephants, or other large zoo animals. Despite the potential for extrapolation error, the reality is that interspecies scaling is needed across many veterinary practice situations, and therefore will be used. For this reason, it is important to consider mechanisms for reducing the risk of extrapolation errors that can seriously affect animal safety and therapeutic response. Overall, although interspecies scaling requires continuous refinement and better understanding, the rationale approach of interspecies scaling has a lot of potential during the drug development process. JF - Advanced Drug Delivery Reviews AU - Mahmood, Iftekhar AD - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1451 Rockville Pike, MD, USA, Iftekhar.mahmood@fda.hhs.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1177 EP - 1192 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 59 IS - 11 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Veterinary medicine KW - Data processing KW - Body weight KW - Elephantidae KW - Drug development KW - Scaling KW - Pharmacokinetics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19909906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Application+of+allometric+principles+for+the+prediction+of+pharmacokinetics+in+human+and+veterinary+drug+development&rft.au=Mahmood%2C+Iftekhar&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2007-09-01&rft.volume=59&rft.issue=11&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.05.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Elephantidae; Pharmacokinetics; Scaling; Drug development; Veterinary medicine; Body weight; Data processing; Drug delivery DO - http://dx.doi.org/10.1016/j.addr.2007.05.015 ER - TY - JOUR T1 - The Role of Exposure Versus Body Burden Data in Deriving Health Guidance Values AN - 19793150; 8609878 AB - The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values to estimate daily human exposure to hazardous substances that are likely to be without appreciable risk of adverse noncancer effects for specific routes and durations of exposure. Most of these guidance values are derived from data showing external dose/health effect relationships. However, for chemicals that persist in the body, information on body burdens may provide more accurate understanding of their toxicity. This article evaluates the exposure versus body burden approaches using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and lead as examples. JF - Journal of Toxicology and Environmental Health, Part B: Critical Reviews AU - Pohl, Hana R AU - Abadin, Henry G AU - Jones, Dennis E AU - De Rosa, Christopher T AD - U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 401 EP - 415 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 10 IS - 6 SN - 1093-7404, 1093-7404 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Data processing KW - Reviews KW - body burden KW - TCDD KW - Toxicity KW - Lead KW - H 14000:Toxicology KW - R2 23060:Medical and environmental health KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19793150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+B%3A+Critical+Reviews&rft.atitle=The+Role+of+Exposure+Versus+Body+Burden+Data+in+Deriving+Health+Guidance+Values&rft.au=Pohl%2C+Hana+R%3BAbadin%2C+Henry+G%3BJones%2C+Dennis+E%3BDe+Rosa%2C+Christopher+T&rft.aulast=Pohl&rft.aufirst=Hana&rft.date=2007-09-01&rft.volume=10&rft.issue=6&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+B%3A+Critical+Reviews&rft.issn=10937404&rft_id=info:doi/10.1080%2F10937400601188070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; TCDD; Toxicity; Lead; Chemicals; Reviews; body burden DO - http://dx.doi.org/10.1080/10937400601188070 ER - TY - JOUR T1 - Widening Socioeconomic Disparities in US Childhood Mortality, 1969-2000 AN - 19741720; 7554421 AB - OBJECTIVES: We examined the extent to which area socioeconomic inequalities in overall and cause-specific mortality among US children aged 1-14 years changed between 1969 and 2000. METHODS: We linked a census-based deprivation index to US county mortality data from 1969 to 2000. We used Poisson and log-linear regression and inequality indices to analyze temporal disparities. RESULTS: Despite marked declines in child mortality, socioeconomic gradients (relative mortality risks) in overall child mortality increased substantially during the study period. During 1969-1971, children in the most deprived socioeconomic quintile had 52%, 13%, 69%, and 76% higher risks of all-cause, birth defect, unintentional injury, and homicide mortality, respectively, than did children in the least deprived socioeconomic quintile. The corresponding relative risks increased to 86%, 44%, 177%, 159%, respectively from 1998-2000. CONCLUSIONS: Dramatic reductions in mortality among children in all socioeconomic quintiles represent a major public health success. However, children in higher socioeconomic quintiles experienced much larger declines in overall, injury, and natural-cause mortality than did those in more deprived socioeconomic quintiles, which contributed to the widening socioeconomic gap in mortality. Widening disparities in child mortality may reflect increasing polarization among deprivation quintiles in material and social conditions. JF - American Journal of Public Health AU - Singh, Gopal K AU - Kogan, Michael D AD - Gopal K. Singh and Michael D. Kogan are with the Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1658 EP - 1665 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 9 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - homicide KW - Injuries KW - Socioeconomics KW - Congenital defects KW - social conditions KW - Children KW - Polarization KW - Public health KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Widening+Socioeconomic+Disparities+in+US+Childhood+Mortality%2C+1969-2000&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2007-09-01&rft.volume=97&rft.issue=9&rft.spage=1658&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; homicide; Injuries; Congenital defects; Socioeconomics; social conditions; Polarization; Children; Public health ER - TY - JOUR T1 - US FDA's revised consumption factor for polystyrene used in food-contact applications AN - 19613584; 8681751 AB - US FDA's continual effort to evaluate the safety of food-contact materials includes periodically re-examining our established packaging factors, such as consumption and food-type distribution factors. The use of polystyrene in food-contact and disposable food-packaging applications has expanded and is expected to continue to increase in the future. Therefore, it is important to revise the polystyrene consumption factor to account for increases in consumer exposure to substances migrating from styrenic food packaging. The currently used consumption factor for polystyrene is 0.1, which is based on market data collected around 1980. US FDA has revised the polystyrene consumption factor utilizing three different sources of market data. Using consumption and population data, US FDA calculated a new consumption factor of 0.14 for polystyrene. This consumption factor has been further subdivided to allow for the refinement of exposure estimates for uses limited to specific subcategories of polystyrene packaging. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Cassidy, K AU - Elyashiv-Barad, S AD - Division of Food Contact Notifications, US Food and Drug Administration, College Park, MD, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1026 EP - 1031 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 24 IS - 9 SN - 0265-203X, 0265-203X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Food additives KW - USA KW - FDA KW - Packaging KW - H 9000:Consumer and Recreation Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=US+FDA%27s+revised+consumption+factor+for+polystyrene+used+in+food-contact+applications&rft.au=Cassidy%2C+K%3BElyashiv-Barad%2C+S&rft.aulast=Cassidy&rft.aufirst=K&rft.date=2007-09-01&rft.volume=24&rft.issue=9&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030701313797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; FDA; Packaging; Risk assessment; Food additives DO - http://dx.doi.org/10.1080/02652030701313797 ER - TY - JOUR T1 - Water separator shows potential for reducing respirable dust generated on small-diameter rotary blasthole drills AN - 17695423; 7605460 AB - Drilling with water has the potential to significantly reduce the respirable dust concentrations generated from small-diameter rotary drills when drilling blastholes on surface mining operations. However, water adversely affects tri-cone drill bits commonly used in surface drilling operations, causing excessive wear and premature replacement. Consequently, dry drilling with a dust collector system has the most widespread use in the industry. Tests have been conducted by the National Institute of Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory (PRL) on a newly designed device for smaller diameter drills that separates the water from the bailing air before it reaches the bit and thus provides the cost benefit of dry drilling while providing the benefit of wet drilling for dust suppression. The water that is delivered to the hole with the bailing air is separated from the air by a proprietary mechanical device that is encased in a drill sub (short section of drill rod/pipe) located immediately behind the cutting bit. A cascade cyclone and a real-time dust monitor were used to sample dust emissions from the holes. Dust concentrations and silica content were measured when drilling dry versus drilling wet. The tests show that drilling with this water separating sub can reduce both measured dust emissions from the boreholes and visible dust around the drill rig. JF - International Journal of Mining, Reclamation and Environment AU - Listak, J M AU - Reed, W R AD - Pittsburgh Research Laboratory, Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA, jlistak@cdc.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 160 EP - 172 VL - 21 IS - 3 SN - 1748-0930, 1748-0930 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Inhalation KW - Pipes KW - boreholes KW - silica KW - reclamation KW - Emissions KW - Mining KW - wear KW - Dust collectors KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17695423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.atitle=Water+separator+shows+potential+for+reducing+respirable+dust+generated+on+small-diameter+rotary+blasthole+drills&rft.au=Listak%2C+J+M%3BReed%2C+W+R&rft.aulast=Listak&rft.aufirst=J&rft.date=2007-09-01&rft.volume=21&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.issn=17480930&rft_id=info:doi/10.1080%2F17480930601176846 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Pipes; boreholes; silica; reclamation; Emissions; Mining; Dust collectors; wear; Occupational exposure DO - http://dx.doi.org/10.1080/17480930601176846 ER - TY - JOUR T1 - Unintended Consequences of Information Technologies in Health Care-An Interactive Sociotechnical Analysis AN - 17274449; 7613683 AB - Many unintended and undesired consequences of Healthcare Information Technologies (HIT) flow from interactions between the HIT and the healthcare organization's sociotechnical system-its workflows, culture, social interactions, and technologies. This paper develops and illustrates a conceptual model of these processes that we call Interactive Sociotechnical Analysis (ISTA). ISTA captures common types of interaction with special emphasis on recursive processes, i.e., feedback loops that alter the newly introduced HIT and promote second-level changes in the social system. ISTA draws on prior studies of unintended consequences, along with research in sociotechnical systems, ergonomics, social informatics, technology-in-practice, and social construction of technology. We present five types of sociotechnical interaction and illustrate each with cases from published research. The ISTA model should further research on emergent and recursive processes in HIT implementation and their unintended consequences. Familiarity with the model can also foster practitioners' awareness of unanticipated consequences that only become evident during HIT implementation. JF - Journal of the American Medical Informatics Association AU - Harrison, Michael I AU - Koppel, Ross AU - Bar-Lev, Shirly AD - Agency for Healthcare Research and Quality, Rockville, MD. University of Pennsylvania, Philadelphia, PA. Ruppin Academic Center, Emek Hefer, Israel Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 542 EP - 549 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 14 IS - 5 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Feedback KW - Models KW - Social interactions KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17274449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Unintended+Consequences+of+Information+Technologies+in+Health+Care-An+Interactive+Sociotechnical+Analysis&rft.au=Harrison%2C+Michael+I%3BKoppel%2C+Ross%3BBar-Lev%2C+Shirly&rft.aulast=Harrison&rft.aufirst=Michael&rft.date=2007-09-01&rft.volume=14&rft.issue=5&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Feedback; Social interactions; Models ER - TY - CPAPER T1 - Fabry Disease: What Pediatric Nephrologists should Know? T2 - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AN - 39422996; 4646330 JF - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AU - Cho, M Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 KW - Pediatrics KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.atitle=Fabry+Disease%3A+What+Pediatric+Nephrologists+should+Know%3F&rft.au=Cho%2C+M&rft.aulast=Cho&rft.aufirst=M&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ipna2007.com/final_programme/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repetitive Exposures of Stretch-Shortening Cycles Affects Muscle Performance Differentially with Age T2 - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AN - 39670129; 4698997 JF - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AU - Cutlip, R G AU - Baker, B A AU - Mercer, R R AU - Kashon, M L AU - Alway, S E Y1 - 2007/08/27/ PY - 2007 DA - 2007 Aug 27 KW - Muscles KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39670129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=Repetitive+Exposures+of+Stretch-Shortening+Cycles+Affects+Muscle+Performance+Differentially+with+Age&rft.au=Cutlip%2C+R+G%3BBaker%2C+B+A%3BMercer%2C+R+R%3BKashon%2C+M+L%3BAlway%2C+S+E&rft.aulast=Cutlip&rft.aufirst=R&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.premus2007.org/conference-program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prospective Study of Risk Factors for Low Back Disorders due to Manual Lifting: Exposure Assessment Methods T2 - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AN - 39537133; 4699303 JF - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AU - Waters, T AU - Piacitelli, L AU - Lu, M. AU - Werren, D Y1 - 2007/08/27/ PY - 2007 DA - 2007 Aug 27 KW - Lifting KW - Risk factors KW - Manuals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=Prospective+Study+of+Risk+Factors+for+Low+Back+Disorders+due+to+Manual+Lifting%3A+Exposure+Assessment+Methods&rft.au=Waters%2C+T%3BPiacitelli%2C+L%3BLu%2C+M.%3BWerren%2C+D&rft.aulast=Waters&rft.aufirst=T&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.premus2007.org/conference-program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy and Reliability of Human Postural Simulation for Assessing Physical Risk Factors Associated with Low Back Disorders T2 - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AN - 39530098; 4699062 JF - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AU - Lu, M. AU - Waters, T AU - Piacitelli, L AU - Werren, D Y1 - 2007/08/27/ PY - 2007 DA - 2007 Aug 27 KW - Simulation KW - Posture KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=Accuracy+and+Reliability+of+Human+Postural+Simulation+for+Assessing+Physical+Risk+Factors+Associated+with+Low+Back+Disorders&rft.au=Lu%2C+M.%3BWaters%2C+T%3BPiacitelli%2C+L%3BWerren%2C+D&rft.aulast=Lu&rft.aufirst=M.&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.premus2007.org/conference-program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NIOSH Musculoskeletal Disorder Consortium T2 - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AN - 39529675; 4698978 JF - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007) AU - Burt, S AU - Waters, T AU - Piacitelli, L AU - Fine, L AU - Silverstein, B AU - Marras, W AU - Garg, A AU - Hegmann, K AU - Rempel, D AU - Gerr, F AU - Cherniak, M AU - Evanoff, B Y1 - 2007/08/27/ PY - 2007 DA - 2007 Aug 27 KW - Musculoskeletal system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39529675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=The+NIOSH+Musculoskeletal+Disorder+Consortium&rft.au=Burt%2C+S%3BWaters%2C+T%3BPiacitelli%2C+L%3BFine%2C+L%3BSilverstein%2C+B%3BMarras%2C+W%3BGarg%2C+A%3BHegmann%2C+K%3BRempel%2C+D%3BGerr%2C+F%3BCherniak%2C+M%3BEvanoff%2C+B&rft.aulast=Burt&rft.aufirst=S&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.premus2007.org/conference-program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Systems Toxicology on the 3Rs T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39725296; 4721562 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Fuscoe, James C Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Toxicology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39725296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Impact+of+Systems+Toxicology+on+the+3Rs&rft.au=Fuscoe%2C+James+C&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity Screening of Herbal Extracts Using Transcriptional Activation System T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39605734; 4721744 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Lim, Chaehyung Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Toxicity KW - Transcription activation KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Toxicity+Screening+of+Herbal+Extracts+Using+Transcriptional+Activation+System&rft.au=Lim%2C+Chaehyung&rft.aulast=Lim&rft.aufirst=Chaehyung&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current Status of the Developmental and Reproductive Toxicity Tests in NITR, Korea T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39591872; 4721479 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Park, Kui Lea Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Korea, Rep. KW - Toxicity testing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39591872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Current+Status+of+the+Developmental+and+Reproductive+Toxicity+Tests+in+NITR%2C+Korea&rft.au=Park%2C+Kui+Lea&rft.aulast=Park&rft.aufirst=Kui&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Databases and QSARs for Chemical Toxicities in Animals and Adverse Effects in Humans T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39580994; 4721844 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Benz, Daniel R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Toxicity KW - Side effects KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Databases+and+QSARs+for+Chemical+Toxicities+in+Animals+and+Adverse+Effects+in+Humans&rft.au=Benz%2C+Daniel+R&rft.aulast=Benz&rft.aufirst=Daniel&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicological and Clinical Computational Analyis and the US FDA/CDER T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39578033; 4721500 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Benz, Daniel R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - FDA KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Toxicological+and+Clinical+Computational+Analyis+and+the+US+FDA%2FCDER&rft.au=Benz%2C+Daniel+R&rft.aulast=Benz&rft.aufirst=Daniel&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICCVAM Revised Recommended Substances for the Validation of In Vitro Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Test Methods T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39576362; 4721859 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Hattan, David Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Estrogen receptors KW - Transcription activation KW - Androgen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=The+identification+of+antibacterial+compounds+for+the+development+of+enhanced+media+for+the+detection+of+foodborne+fungi&rft.au=Tournas%2C+V+H%3BKohn%2C+J+S%3BKatsoudas%2C+E+J&rft.aulast=Tournas&rft.aufirst=V&rft.date=2007-08-01&rft.volume=118&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2007.04.013 L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NICEATM and ICCVAM Evaluation of Five In Vitro Test Methods for Assessing Potential Pyrogenicity of Pharmaceuticals and other Products T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39532303; 4721881 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - McFarland, Richard Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Pharmaceuticals KW - Pyrogenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39532303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=NICEATM+and+ICCVAM+Evaluation+of+Five+In+Vitro+Test+Methods+for+Assessing+Potential+Pyrogenicity+of+Pharmaceuticals+and+other+Products&rft.au=McFarland%2C+Richard&rft.aulast=McFarland&rft.aufirst=Richard&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Usnic Acid from Usnea sp. Dispersed in Rodent Diet by HPLC T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39492669; 4629620 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Evans, Ronald L AU - Siitonen, Paul H Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Diets KW - Rodents KW - Usnic acid KW - High-performance liquid chromatography KW - Usnea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39492669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Analysis+of+Usnic+Acid+from+Usnea+sp.+Dispersed+in+Rodent+Diet+by+HPLC&rft.au=Evans%2C+Ronald+L%3BSiitonen%2C+Paul+H&rft.aulast=Evans&rft.aufirst=Ronald&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Dietary Components on Acrylamide Induced Neurotransmitter Turnover Alterations in Pc 12 Cells T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39459224; 4635277 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Tareke, Eden AU - Ali, Syed AU - Lyn-Cook, Beverly AU - Duhart, Helen M Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Diets KW - Neurotransmitters KW - Acrylamide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39459224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Role+of+Dietary+Components+on+Acrylamide+Induced+Neurotransmitter+Turnover+Alterations+in+Pc+12+Cells&rft.au=Tareke%2C+Eden%3BAli%2C+Syed%3BLyn-Cook%2C+Beverly%3BDuhart%2C+Helen+M&rft.aulast=Tareke&rft.aufirst=Eden&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Irradiation of Retinol in Ethanol with UVA Light: Formation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39455857; 4635243 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Xia, Qingsu AU - Yin, Jun Jie AU - Cherng, Shu-Hui AU - Freeman, James P AU - Yu, Hongtao AU - Boudreau, Mary D AU - Wamer, Wayne G AU - Fu, Peter P Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Ethanol KW - Reactive oxygen species KW - Lipid peroxidation KW - Irradiation KW - U.V. radiation KW - Radiation KW - Peroxide KW - Vitamin A KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39455857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Irradiation+of+Retinol+in+Ethanol+with+UVA+Light%3A+Formation+of+Photodecomposition+Products%2C+Reactive+Oxygen+Species%2C+and+Lipid+Peroxides&rft.au=Xia%2C+Qingsu%3BYin%2C+Jun+Jie%3BCherng%2C+Shu-Hui%3BFreeman%2C+James+P%3BYu%2C+Hongtao%3BBoudreau%2C+Mary+D%3BWamer%2C+Wayne+G%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Perfluorochemicals in Food Packaging by Direct Analysis in Real Time-mass Spectrometry (dart-MS) T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39432614; 4629511 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Noonan, Gregory O AU - Begley, Timothy H AU - Diachenko, Gregory W Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Spectrometry KW - Packaging KW - Perfluorochemicals KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39432614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Characterization+of+Perfluorochemicals+in+Food+Packaging+by+Direct+Analysis+in+Real+Time-mass+Spectrometry+%28dart-MS%29&rft.au=Noonan%2C+Gregory+O%3BBegley%2C+Timothy+H%3BDiachenko%2C+Gregory+W&rft.aulast=Noonan&rft.aufirst=Gregory&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Modern Extraction Methods for the Analysis of Tetramethylene Disulfotetramine in Foods T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39432560; 4629505 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Dejager, Lowri AU - Perfetti, Gracia A AU - Diachenko, Gregory W Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39432560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Evaluation+of+Modern+Extraction+Methods+for+the+Analysis+of+Tetramethylene+Disulfotetramine+in+Foods&rft.au=Dejager%2C+Lowri%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=Dejager&rft.aufirst=Lowri&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Nitrofuran Residues in Shrimp, Channel Catfish, and Milk using Liquid Chromatography-Tandem Mass Spectrometry T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39429379; 4636250 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Chu, Pak-Sin AU - Lopez, Mayda I AU - Abraham, Ann AU - El Said, Kathleen R AU - Plakas, Steven M Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Mass spectroscopy KW - Residues KW - Milk KW - Nitrofurans KW - Freshwater fish KW - Ictalurus punctatus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39429379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Analysis+of+Nitrofuran+Residues+in+Shrimp%2C+Channel+Catfish%2C+and+Milk+using+Liquid+Chromatography-Tandem+Mass+Spectrometry&rft.au=Chu%2C+Pak-Sin%3BLopez%2C+Mayda+I%3BAbraham%2C+Ann%3BEl+Said%2C+Kathleen+R%3BPlakas%2C+Steven+M&rft.aulast=Chu&rft.aufirst=Pak-Sin&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Niosh: Nanotechnologies Safety and Health Initiatives T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39412712; 4632658 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Hoover, Mark Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Nanotechnology KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39412712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Niosh%3A+Nanotechnologies+Safety+and+Health+Initiatives&rft.au=Hoover%2C+Mark&rft.aulast=Hoover&rft.aufirst=Mark&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PBPK/PD Modeling of Acrylamide: Integration of Kinetic and Biomarker Data for Use in Risk Assessment T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39375623; 4629694 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Doerge, Daniel R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Bioindicators KW - Risk assessment KW - Kinetics KW - Integration KW - Acrylamide KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39375623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=PBPK%2FPD+Modeling+of+Acrylamide%3A+Integration+of+Kinetic+and+Biomarker+Data+for+Use+in+Risk+Assessment&rft.au=Doerge%2C+Daniel+R&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Some Applications of GC-MS/MS and LC-MS/MS to Analyze Pesticides and Chemical Contaminants in Foods T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39370574; 4629528 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Wong, Jon W AU - Krynitsky, Alexander J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Pesticides KW - Chemical pollution KW - Contaminants KW - Food contamination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39370574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Some+Applications+of+GC-MS%2FMS+and+LC-MS%2FMS+to+Analyze+Pesticides+and+Chemical+Contaminants+in+Foods&rft.au=Wong%2C+Jon+W%3BKrynitsky%2C+Alexander+J&rft.aulast=Wong&rft.aufirst=Jon&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microstructure Characterization of Drug-polymer Composite Coatings T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39363078; 4631314 JF - 234th National Meeting and Exposition of the American Chemical Society AU - McDermott, Martin K AU - Patwardhan, Dinesh V AU - Casas, Rachel AU - Dair, Benita J AU - Kim, Chang-Soo AU - Pollack, Steven K AU - Saylor, Dave M AU - Soffer, Jeffrey M AU - Toy, Jeff AU - Wang, Christine X Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Coating materials KW - Composite materials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39363078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Microstructure+Characterization+of+Drug-polymer+Composite+Coatings&rft.au=McDermott%2C+Martin+K%3BPatwardhan%2C+Dinesh+V%3BCasas%2C+Rachel%3BDair%2C+Benita+J%3BKim%2C+Chang-Soo%3BPollack%2C+Steven+K%3BSaylor%2C+Dave+M%3BSoffer%2C+Jeffrey+M%3BToy%2C+Jeff%3BWang%2C+Christine+X&rft.aulast=McDermott&rft.aufirst=Martin&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery. AN - 85395728; pmid-17656295 JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Shanti, Rabie M AU - Li, Wan-Ju AU - Nesti, Leon J AU - Wang, Xibin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1640 EP - 1647 VL - 65 IS - 8 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult Stem Cells: cytology KW - *Adult Stem Cells: physiology KW - Biocompatible Materials KW - Bone Substitutes KW - Cells, Cultured KW - Hematopoietic Stem Cells: cytology KW - Hematopoietic Stem Cells: physiology KW - Humans KW - Mesenchymal Stem Cells: cytology KW - *Mesenchymal Stem Cells: physiology KW - *Prosthesis Design: methods KW - *Reconstructive Surgical Procedures: methods KW - *Surgery, Oral: methods KW - *Tissue Engineering: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Adult+mesenchymal+stem+cells%3A+biological+properties%2C+characteristics%2C+and+applications+in+maxillofacial+surgery.&rft.au=Shanti%2C+Rabie+M%3BLi%2C+Wan-Ju%3BNesti%2C+Leon+J%3BWang%2C+Xibin%3BTuan%2C+Rocky+S&rft.aulast=Shanti&rft.aufirst=Rabie&rft.date=2007-08-01&rft.volume=70&rft.issue=8&rft.spage=1937&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282007%290702.3.CO%3B2 LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Duration of therapy with metoclopramide: a prescription claims data study. AN - 70759161; 17436356 AB - Metoclopramide-induced tardive dyskinesia is associated with cumulative drug exposure, which can result from prolonged use of the drug. We estimated therapy duration with metoclopramide, and measured the extent of therapy beyond the maximum time period of 12 weeks evaluated in the clinical trials and recommended in the label. Prescription claims for metoclopramide from 2002 to 2004 were extracted for participants residing throughout the US and contained within the Caremark pharmacy benefit manager (PBM) database. An episode of therapy was defined as one or a series of consecutive claims with no more than a 30-day lag between the dispensing date of a new claim and the ending date of the preceding claim. Episode duration was calculated by subtracting the start date from the end date for each episode. During the study period, almost 80% of participants (total = 200 907) had only one episode of therapy. The length of the longest episode for most patients (85%) varied from 1 to 90 days, yet 15% of the patients appeared to have received prescriptions for metoclopramide for a period longer than 90 days. Cumulative therapy for longer than 90 days was recorded for almost 20% of the patients. These results suggest that despite the known risk of tardive dyskinesia and the labeled recommendations on duration of metoclopramide use, many patients appear to use the drug for relatively long time periods beyond the labeled recommendations. Physicians should carefully consider the risk-benefit profile of the drug and, if possible, avoid increased risk of tardive dyskinesia due to prolonged exposure. JF - Pharmacoepidemiology and drug safety AU - Kaplan, Sigal AU - Staffa, Judy A AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD 20993, USA. sigal.kaplan@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 878 EP - 881 VL - 16 IS - 8 SN - 1053-8569, 1053-8569 KW - Antiemetics KW - 0 KW - Metoclopramide KW - L4YEB44I46 KW - Index Medicus KW - Risk KW - Drug Administration Schedule KW - Insurance, Pharmaceutical Services -- statistics & numerical data KW - Humans KW - Adult KW - Practice Guidelines as Topic KW - Databases, Factual KW - Aged KW - Middle Aged KW - Drug Labeling KW - Drug Prescriptions KW - Antiemetics -- administration & dosage KW - Metoclopramide -- administration & dosage KW - Dyskinesia, Drug-Induced -- etiology KW - Antiemetics -- adverse effects KW - Practice Patterns, Physicians' -- standards KW - Metoclopramide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Duration+of+therapy+with+metoclopramide%3A+a+prescription+claims+data+study.&rft.au=Kaplan%2C+Sigal%3BStaffa%2C+Judy+A%3BDal+Pan%2C+Gerald+J&rft.aulast=Kaplan&rft.aufirst=Sigal&rft.date=2007-08-01&rft.volume=16&rft.issue=8&rft.spage=878&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-23 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. AN - 70745663; 17550941 AB - Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt) resulting in aggregation of mutant Htt into nuclear and/or cytosolic inclusions in neurons. Mutant Htt affects multiple processes including protein degradation, transcription, signal transduction, fast axonal transport and endocytosis [reviewed in Ross, C.A. and Poirier, M.A. (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat. Rev. Mol. Cell. Biol., 6, 891-898]. Here, we report that the endocytic and signal transduction scaffold intersectin (ITSN) increased aggregate formation by mutant Htt through activation of the c-Jun-NH(2)-terminal kinase (JNK)-MAPK pathway. Conversely, silencing ITSN or inhibiting JNK attenuated aggregate formation. Using a Drosophila model for polyQ repeat disease, we observed that ITSN enhanced polyQ-mediated neurotoxicity. A reciprocal relationship was observed between ITSN and Htt. While ITSN enhanced Htt aggregation and toxicity, Htt, in turn, inhibited the cooperativity between ITSN and the epidermal growth factor receptor signal transduction pathway. Finally, we observed that ITSN overexpression enhanced aggregation of polyQ-expanded androgen receptor (AR) as well as wild-type versions of both Htt and AR suggesting a broader involvement of ITSN in neurodegenerative diseases through destabilization of polyQ-containing proteins. JF - Human molecular genetics AU - Scappini, Erica AU - Koh, Tong-Wey AU - Martin, Negin P AU - O'Bryan, John P AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1862 EP - 1871 VL - 16 IS - 15 SN - 0964-6906, 0964-6906 KW - Adaptor Proteins, Vesicular Transport KW - 0 KW - HTT protein, human KW - Huntingtin Protein KW - Nerve Tissue Proteins KW - Nuclear Proteins KW - Peptides KW - Recombinant Fusion Proteins KW - intersectin 1 KW - polyglutamine KW - 26700-71-0 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Neurons -- metabolism KW - COS Cells KW - Enzyme Activation KW - Humans KW - Drosophila -- metabolism KW - Peptides -- metabolism KW - Mice KW - Recombinant Fusion Proteins -- metabolism KW - Cells, Cultured KW - Cercopithecus aethiops KW - Recombinant Fusion Proteins -- genetics KW - Drosophila -- genetics KW - Mutation KW - Signal Transduction KW - Nuclear Proteins -- analysis KW - Nerve Tissue Proteins -- analysis KW - Huntington Disease -- metabolism KW - Adaptor Proteins, Vesicular Transport -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Huntington Disease -- enzymology KW - Adaptor Proteins, Vesicular Transport -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70745663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Intersectin+enhances+huntingtin+aggregation+and+neurodegeneration+through+activation+of+c-Jun-NH2-terminal+kinase.&rft.au=Scappini%2C+Erica%3BKoh%2C+Tong-Wey%3BMartin%2C+Negin+P%3BO%27Bryan%2C+John+P&rft.aulast=Scappini&rft.aufirst=Erica&rft.date=2007-08-01&rft.volume=16&rft.issue=15&rft.spage=1862&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhalation of toluene diisocyanate vapor induces allergic rhinitis in mice. AN - 70726777; 17641053 AB - Diisocyanates are the leading cause of occupational asthma, and epidemiological evidence suggests that occupational rhinitis is a comorbid and preceding condition in patients who develop asthma. The goal of the present studies was to develop and characterize a murine model of toluene diisocyanate (TDI)-induced rhinitis. Female C57BL/6 mice were exposed to workplace-relevant concentrations of TDI vapor via inhalation for 4 h/day for 12 days with or without a 2-wk rest period and TDI challenge. Mice exposed 12 consecutive weekdays to 50 parts per billion TDI vapor showed elevated total serum IgE and increased TDI-specific IgG titers. Breathing rates were decreased corresponding with increased inspiratory time. TDI exposure elevated IL-4, IL-5, IL-13, and IFN-gamma mRNA expression in the nasal mucosa, suggesting a mixed Th1/Th2 immune response. Expressions of mRNA for proinflammatory cytokines and adhesion molecules were also up-regulated. These cytokine changes corresponded with a marked influx of inflammatory cells into the nasal mucosa, eosinophils being the predominant cell type. Removal from exposure for 2 wk resulted in reduced Ab production, cytokine mRNA expression, and cellular inflammation. Subsequent challenge with 50 parts per billion TDI vapor resulted in robust up-regulation of Ab production, cytokine gene expression, as well as eosinophilic inflammation in the nasal mucosa. There were no associated changes in the lung. The present model shows that TDI inhalation induces immune-mediated allergic rhinitis, displaying the major features observed in human disease. Future studies will use this model to define disease mechanisms and examine the temporal/dose relationship between TDI-induced rhinitis and asthma. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Johnson, Victor J AU - Yucesoy, Berran AU - Reynolds, Jeff S AU - Fluharty, Kara AU - Wang, Wei AU - Richardson, Diana AU - Luster, Michael I AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. vjohnson3@cdc.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1864 EP - 1871 VL - 179 IS - 3 SN - 0022-1767, 0022-1767 KW - Aerosols KW - 0 KW - Cytokines KW - Immunoglobulin G KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - Immunoglobulin E KW - 37341-29-0 KW - Abridged Index Medicus KW - Index Medicus KW - Th1 Cells -- immunology KW - Nasal Mucosa -- pathology KW - Animals KW - Occupational Diseases -- immunology KW - Immunoglobulin E -- blood KW - Random Allocation KW - Cytokines -- biosynthesis KW - Nasal Mucosa -- immunology KW - Th1 Cells -- metabolism KW - Mice KW - Nasal Mucosa -- metabolism KW - Immunoglobulin E -- biosynthesis KW - Th2 Cells -- pathology KW - Occupational Diseases -- chemically induced KW - Th2 Cells -- metabolism KW - Antibody Specificity KW - Th1 Cells -- pathology KW - Mice, Inbred C57BL KW - Occupational Diseases -- pathology KW - Administration, Inhalation KW - Th2 Cells -- immunology KW - Immunoglobulin G -- biosynthesis KW - Female KW - Toluene 2,4-Diisocyanate -- administration & dosage KW - Rhinitis, Allergic, Perennial -- immunology KW - Toluene 2,4-Diisocyanate -- immunology KW - Rhinitis, Allergic, Perennial -- pathology KW - Disease Models, Animal KW - Rhinitis, Allergic, Perennial -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Inhalation+of+toluene+diisocyanate+vapor+induces+allergic+rhinitis+in+mice.&rft.au=Johnson%2C+Victor+J%3BYucesoy%2C+Berran%3BReynolds%2C+Jeff+S%3BFluharty%2C+Kara%3BWang%2C+Wei%3BRichardson%2C+Diana%3BLuster%2C+Michael+I&rft.aulast=Johnson&rft.aufirst=Victor&rft.date=2007-08-01&rft.volume=179&rft.issue=3&rft.spage=1864&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating active bone marrow dose from occupational exposure to uranium at a former gaseous diffusion plant. AN - 70703885; 17622815 AB - Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the 581 study subjects. These data were used to determine intakes of uranium as a result of occupational exposure during operation of the K-25 facility. Uranium solubility was inferred from the observed urinary excretion rate, job titles, and department codes. Data suggest that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. The median cumulative bone marrow dose determined for subjects with bioassay data was 0.06 mGy with a geometric standard deviation of 4.48. Subjects without bioassay data were assigned cumulative bone marrow dose based upon job titles and department codes. JF - Health physics AU - Anderson, J L AU - Spitz, H B AU - Yiin, J H AD - Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226, USA. JLAnderson@cdc.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 113 EP - 119 VL - 93 IS - 2 SN - 0017-9078, 0017-9078 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Body Burden KW - Occupational Exposure KW - Uranium -- urine KW - Bone Marrow -- radiation effects KW - Bone Marrow -- chemistry KW - Uranium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70703885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Estimating+active+bone+marrow+dose+from+occupational+exposure+to+uranium+at+a+former+gaseous+diffusion+plant.&rft.au=Anderson%2C+J+L%3BSpitz%2C+H+B%3BYiin%2C+J+H&rft.aulast=Anderson&rft.aufirst=J&rft.date=2007-08-01&rft.volume=93&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-05 N1 - Date created - 2007-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety monitoring of drugs granted exclusivity under the Best Pharmaceuticals for Children Act: what the FDA has learned. AN - 70703666; 17632537 AB - The Best Pharmaceuticals for Children Act (BPCA) was signed into law on 4 January 2002, shortly after the pediatric exclusivity provision of the Food and Drug Administration (FDA) Modernization Act expired on 1 January 2002. This Act provides six months of marketing exclusivity for a drug when a pharmaceutical company studies that drug for use in the pediatric population as requested by the FDA. Section 17 of the BPCA specifically requires that the FDA review all adverse events reported for drugs that receive pediatric exclusivity. In most of the cases, no unexpected adverse events were reported in the pediatric population; however, in some cases, this focused safety review provided information important to the safety of medication use in children. JF - Clinical pharmacology and therapeutics AU - Mathis, L L AU - Iyasu, S AD - Office of New Drugs, US Public Health Service, Silver Spring, Maryland, USA. Lisa.Mathis@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 133 EP - 134 VL - 82 IS - 2 SN - 0009-9236, 0009-9236 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Child KW - Product Surveillance, Postmarketing -- methods KW - Government Regulation KW - Drug-Related Side Effects and Adverse Reactions -- prevention & control KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70703666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Safety+monitoring+of+drugs+granted+exclusivity+under+the+Best+Pharmaceuticals+for+Children+Act%3A+what+the+FDA+has+learned.&rft.au=Mathis%2C+L+L%3BIyasu%2C+S&rft.aulast=Mathis&rft.aufirst=L&rft.date=2007-08-01&rft.volume=82&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-11 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of Shiga toxigenic Escherichia coli seropathotypes A and B by multiplex PCR. AN - 70506913; 17383154 AB - A multiplex PCR assay was developed to identify the six clinically important enterohemorrhagic Escherichia coli (EHEC) serotypes classified in seropathotypes A and B and to differentiate these from Shiga toxigenic E. coli. The assay simultaneously detects genes for Shiga toxin (stx) and intimin (eae), including allelic variants of both genes, 16S internal amplification control, as well as unique sequences in the wzx genes that are specific for serotypes O157, O26, O111, O103, O121 and O145. PCR analysis of 40 representative strains showed that the assay correctly identified the virulence genes, if present, and the respective O antigen type of all the strains, including some atypical EHEC, as well as enteropathogenic E. coli and E. coli strains examined. JF - Molecular and cellular probes AU - Monday, S R AU - Beisaw, A AU - Feng, P C H AD - Division of Microbiological Studies, US Food and Drug Administration, College Park, MD 20740, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 308 EP - 311 VL - 21 IS - 4 SN - 0890-8508, 0890-8508 KW - DNA, Bacterial KW - 0 KW - Shiga Toxin KW - 75757-64-1 KW - Index Medicus KW - Escherichia coli -- isolation & purification KW - Shiga Toxin -- genetics KW - Escherichia coli -- classification KW - DNA, Bacterial -- genetics KW - Polymerase Chain Reaction -- methods KW - Escherichia coli -- genetics KW - DNA, Bacterial -- analysis KW - Bacterial Typing Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70506913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+probes&rft.atitle=Identification+of+Shiga+toxigenic+Escherichia+coli+seropathotypes+A+and+B+by+multiplex+PCR.&rft.au=Monday%2C+S+R%3BBeisaw%2C+A%3BFeng%2C+P+C+H&rft.aulast=Monday&rft.aufirst=S&rft.date=2007-08-01&rft.volume=21&rft.issue=4&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+probes&rft.issn=08908508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-31 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and molecular characterization of Salmonella spp. from unpasteurized orange juices and identification of new serotype Salmonella strain S. enterica serovar Tempe. AN - 70283978; 17367687 AB - Several Salmonella enterica serotypes were isolated from unpasteurized orange juice samples analysed as a follow-up to an outbreak in 1999 of S. enterica serotype Muenchen in the Pacific Northwest regions of United States. Eleven S. enterica strains were serotyped and identified as S. enterica serotype Muenchen (2), S. enterica serotype Hidalgo (2), S. enterica serotype Alamo (1), S. enterica serotype Gaminera (2), S. enterica serotype Javiana (2) and a new serotyped strain S. enterica serotype Tempe (2). The identity of the new serotype S. enterica serovar Tempe serotype 30:b:1,7:z33 was confirmed by the National Salmonella Reference Laboratory at NCID/CDC, Atlanta. These strains were sensitive to ampicillin, chloramphenicol, kanamycin, tetracycline, streptomycin and sulfisoxazole antibiotics. Isolates were screened for invasion (invA) and virulence (spvC) genes using specific primers for these two genes by polymerase chain reaction. All strains were positive for invA gene giving 321-bp fragment, however negative to virulence spvC gene. For pulsed-field gel electrophoresis (PFGE) analysis, Salmonella strain plugs were made and digested with XbaI and subjected to 18-h electrophoresis. The PFGE patterns were different for each S. enterica serotypes suggesting the several origins of contamination in outbreak. S. enterica serotype. JF - Food microbiology AU - Khan, Ashraf A AU - Melvin, Cathy D AU - Dagdag, Elsie B AD - Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Ashraf.khan@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 539 EP - 543 VL - 24 IS - 5 SN - 0740-0020, 0740-0020 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Base Sequence KW - Food Microbiology KW - Drug Resistance, Bacterial KW - Humans KW - DNA, Bacterial -- genetics KW - Polymerase Chain Reaction -- methods KW - Electrophoresis, Gel, Pulsed-Field KW - Anti-Bacterial Agents -- pharmacology KW - Serotyping KW - Disease Outbreaks KW - Microbial Sensitivity Tests KW - Phylogeny KW - Salmonella enterica -- isolation & purification KW - Beverages -- microbiology KW - Food Contamination -- analysis KW - Salmonella Food Poisoning -- epidemiology KW - Salmonella Food Poisoning -- microbiology KW - Salmonella enterica -- classification KW - Citrus sinensis -- microbiology KW - Salmonella enterica -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70283978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+neurology&rft.atitle=Clinical+profile+of+oxcarbazepine-related+angioneurotic+edema%3A+case+report+and+review.&rft.au=Knudsen%2C+James+F%3BFlowers%2C+Charlene+M%3BKortepeter%2C+Cindy%3BAwaad%2C+Yasser&rft.aulast=Knudsen&rft.aufirst=James&rft.date=2007-08-01&rft.volume=37&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Pediatric+neurology&rft.issn=08878994&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a gas chromatographic test for the quantitation of the biomarker 2-butoxyacetic acid in urine samples. AN - 68215033; 17725869 AB - An accurate and precise method is developed and evaluated for the detection and quantitation of 2-butoxyacetic acid (2-BAA), a metabolite and biomarker for human exposure to 2-butoxyethanol. The solvent 2-butoxyethanol (2-BE) is extensively used in various industrial and domestic applications, and it is a health concern owing to its toxicity. Sample preparation consists of liquid-liquid extraction (LLE) of urine, then esterification of 2-BAA to produce the ethyl ester analog. The gas chromatographic conditions utilize a dimethyl polysiloxane phase (HP-1) capillary column and a mass spectrometer (MS) for detection of the analyte. Validation of this method includes a recovery study using fortified urine samples, which demonstrated good accuracy and precision; recovery varied between 100% and 102% of theory, with relative standard deviations of replicate samples at 2.8% and less. The detection limit of this method ranges from 0.005 to 0.015 microg/mL equivalent level of 2-BAA in urine. JF - Journal of chromatographic science AU - B'Hymer, C AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. cbhymer@cdc.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 422 EP - 427 VL - 45 IS - 7 SN - 0021-9665, 0021-9665 KW - Biomarkers KW - 0 KW - Glycolates KW - n-butoxyacetic acid KW - 2516-93-0 KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Reference Standards KW - Biomarkers -- urine KW - Glycolates -- urine KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68215033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Development+of+a+gas+chromatographic+test+for+the+quantitation+of+the+biomarker+2-butoxyacetic+acid+in+urine+samples.&rft.au=B%27Hymer%2C+C&rft.aulast=B%27Hymer&rft.aufirst=C&rft.date=2007-08-01&rft.volume=45&rft.issue=7&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-01 N1 - Date created - 2007-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug hepatotoxicity from a regulatory perspective. AN - 68204370; 17723917 AB - This article summarizes problems of drug-induced liver injury (DILI), as seen from the perspective of the Food and Drug Administration (FDA). After brief consideration of the scope of FDA activities and processes of new drug development and review for possible approval of products for clinical use and marketing, some of the perceived current problems in detection, confirmation, close observation, differential diagnosis, and follow-up of cases of possible DILI in controlled clinical trials are described. Readers are invited to consider possible solutions to the many problems of DILI, propose ways to support research in the field, and keep abreast of progress by visiting the web site at www.fda.gov/cder/livertox. JF - Clinics in liver disease AU - Senior, John R AD - Center for Drug Evaluation and Research, Food and Drug Administration, Federal Research Center at White Oak, Building 22:3482, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. john.senior@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 507 EP - 24, vi VL - 11 IS - 3 SN - 1089-3261, 1089-3261 KW - Index Medicus KW - United States KW - Drug Evaluation KW - United States Food and Drug Administration KW - Humans KW - Clinical Trials as Topic KW - Drug Design KW - Drug and Narcotic Control KW - Drug-Related Side Effects and Adverse Reactions KW - Chemical and Drug Induced Liver Injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68204370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+liver+disease&rft.atitle=Drug+hepatotoxicity+from+a+regulatory+perspective.&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2007-08-01&rft.volume=11&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Clinics+in+liver+disease&rft.issn=10893261&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-08 N1 - Date created - 2007-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway. AN - 68182083; 17630704 AB - The rubber accelerator, 2-mercaptobenzothiazole (MBT), has been reported to cause allergic contact dermatitis from gloves and other rubber products, but its chemical fate when exposed to occupational oxidants and the mechanism of its pathogenesis are not known. It was hypothesized that the thiol group is critical to MBT's (its oxidation products or metabolites) covalent binding and/or haptenation to nucleophilic protein residues. Oxidative transformation of MBT to the disulfide 2,2'-dithiobis(benzothiazole) (MBTS) was observed within the glove matrix when hypochlorous acid, iodine, and hydrogen peroxide were used as oxidants. Cysteine reduced MBTS to MBT with subsequent formation of the mixed disulfide 2-amino-3-(benzothiazol-2-yl disulfanyl)propionic acid which was identified and characterized. Spectrophotometry and mass spectrometry experiments demonstrated the simultaneous reduction of MBTS and disulfide formation with Cys34 on bovine serum albumin, suggesting a potential route of protein haptenation through covalent bonding between protein cysteinyl residues and the MBT/MBTS thiol moiety. Metabolism of MBT using isoniazid and dexamethasone-induced rat liver microsomes, to give a protein reactive epoxide intermediate and provide an alternative protein haptenation mechanism, was not observed. The data suggest that the critical functional group on MBT is the thiol, and haptenation is via the formation of mixed disulfides between the thiol group on MBT and a protein sulfhydryl group. JF - Chemical research in toxicology AU - Chipinda, Itai AU - Hettick, Justin M AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1084 EP - 1092 VL - 20 IS - 8 SN - 0893-228X, 0893-228X KW - Benzothiazoles KW - 0 KW - Disulfides KW - Haptens KW - Latex KW - captax KW - 5RLR54Z22K KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Rats, Sprague-Dawley KW - Disulfides -- chemistry KW - Cysteine -- chemistry KW - Spectrophotometry KW - Time Factors KW - Chromatography, High Pressure Liquid KW - Binding Sites KW - Gloves, Protective KW - Haptens -- metabolism KW - Haptens -- chemistry KW - Metabolic Networks and Pathways KW - Latex -- toxicity KW - Benzothiazoles -- toxicity KW - Dermatitis, Allergic Contact -- pathology KW - Latex -- chemistry KW - Benzothiazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Oxidation+of+2-mercaptobenzothiazole+in+latex+gloves+and+its+possible+haptenation+pathway.&rft.au=Chipinda%2C+Itai%3BHettick%2C+Justin+M%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2007-08-01&rft.volume=20&rft.issue=8&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. AN - 68179865; 17557904 AB - The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we present data evaluating 39 single-nucleotide polymorphisms (SNPs) in seven candidate genes whose products are involved in DNA break sensing (NBS1, BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombination (HR) repair (RAD51, XRCC2 and XRCC3). SNPs for RAD51 and XRCC2 covered most of the common variation. Associations with bladder cancer risk were evaluated in 1,150 newly diagnosed cases of urinary bladder transitional cell carcinomas and 1,149 controls conducted in Spain during 1997-2001. We found that the genetic variants evaluated significantly contributed to bladder cancer risk (global likelihood ratio test P = 0.01). Subjects with the ZNF350 R501S (rs2,278,415) variant allele showed significantly reduced risk compared with common homozygote variants, odds ratio (OR) [95% confidence interval (95% CI)]: 0.76 (0.62-0.93) per variant allele. Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele. Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes). Meta-analysis for XRCC3 T241M (rs861,539) had a significant small increase in risk among homozygote variants: OR (95% CI) = 1.17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - Rothman, Nathaniel AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Yeager, Meredith AU - Welch, Robert AU - Dosemeci, Mustafa AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - García-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1788 EP - 1793 VL - 28 IS - 8 SN - 0143-3334, 0143-3334 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - DNA Repair -- genetics KW - Genetic Variation KW - Urinary Bladder Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - DNA Breaks, Double-Stranded KW - Carcinoma, Transitional Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Evaluation+of+genetic+variation+in+the+double-strand+break+repair+pathway+and+bladder+cancer+risk.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BGarc%C3%ADa-Closas%2C+Montserrat&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of particulate matter air pollution on hospital admissions and medical visits for lung and heart disease in two southeast Idaho cities. AN - 68149095; 17299531 AB - Few, if any, published time series studies have evaluated the effects of particulate matter air exposures by combining hospital admissions with medical visit data for smaller populations. We investigated the relationship between daily particulate matter (<10 microm in aerometric diameter or PM10) exposures with admissions and medical visits (emergency room, urgent care, and family practice) for respiratory and cardiovascular disease in Pocatello and Chubbuck, Idaho (population about 60,000), from November 1994 through March 2000. Within generalized linear models, time, weather, influenza, and day-of-week effects were controlled. In single-pollutant models, respiratory disease admissions and visits increased (7.1-15.4% per 50 microg/m3 PM10) for each age group analyzed, with the highest increases in two groups, children and especially the elderly. Statistical analyses suggest that the results probably did not occur by chance. Sensitivity analyses did not provide strong evidence that the respiratory disease effect estimates were sensitive to reasonable changes in the final degrees of freedom choice for time and weather effects. No strong evidence of confounding by NO2 and SO2 was found from results of multi-pollutant models. Ozone and carbon monoxide data were not available to include multi-pollutant models, but evidence suggests that they were not a problem. Unexpectedly, evidence of an association between PM10 with cardiovascular disease was not found, possibly due to the lifestyles of the mostly Mormon study population. Successful time series analyses can be performed on smaller populations if diverse, centralized databases are available. Hospitals that offer urgent or other primary care services may be a rich source of data for researchers. Using data that potentially represented a wide-range of disease severity, the findings provide evidence that evaluating only hospital admissions or emergency room visit effects may underestimate the overall morbidity due to acute particulate matter exposures. Further work is planned to test this conclusion. JF - Journal of exposure science & environmental epidemiology AU - Ulirsch, Gregory V AU - Ball, Louise M AU - Kaye, Wendy AU - Shy, Carl M AU - Lee, Carolyn V AU - Crawford-Brown, Douglas AU - Symons, Michael AU - Holloway, Tracey AD - Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, GA 30345, USA. gulirsch@cdc.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 478 EP - 487 VL - 17 IS - 5 SN - 1559-0631, 1559-0631 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Carbon Dioxide KW - 142M471B3J KW - Nitrogen Dioxide KW - S7G510RUBH KW - Index Medicus KW - Age Factors KW - Nitrogen Dioxide -- toxicity KW - Humans KW - Linear Models KW - Infant, Newborn KW - Aged KW - Child KW - Models, Biological KW - Infant KW - Seasons KW - Adult KW - Idaho -- epidemiology KW - Middle Aged KW - Adolescent KW - Time Factors KW - Cities -- epidemiology KW - Carbon Dioxide -- toxicity KW - Particulate Matter -- toxicity KW - Lung Diseases -- etiology KW - Air Pollution -- adverse effects KW - Hospitalization -- statistics & numerical data KW - Air Pollutants -- toxicity KW - Heart Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68149095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Effect+of+particulate+matter+air+pollution+on+hospital+admissions+and+medical+visits+for+lung+and+heart+disease+in+two+southeast+Idaho+cities.&rft.au=Ulirsch%2C+Gregory+V%3BBall%2C+Louise+M%3BKaye%2C+Wendy%3BShy%2C+Carl+M%3BLee%2C+Carolyn+V%3BCrawford-Brown%2C+Douglas%3BSymons%2C+Michael%3BHolloway%2C+Tracey&rft.aulast=Ulirsch&rft.aufirst=Gregory&rft.date=2007-08-01&rft.volume=17&rft.issue=5&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=15590631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. AN - 68147812; 17684125 AB - alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis. We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend) T variant [odds ratio (OR) sub(AT), 0.8; 95% confidence interval (95% CI), 0.5-1.2; OR sub(AA), 0.5; 95% CI, 0.3-0.9; P sub(trend) = 0.03] and increased risk of meningioma with the CASP8 Ex13+51G>C variant (OR sub(GC), 1.4; 95% CI, 0.9-2.1; OR sub(CC), 3.6; 95% CI, 1.0-13.1; P sub(trend) = 0.04). The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma. The CCND1 Ex4-1G>A variant was associated with increased risk for glioma, and the Ex8+49T>C variant of CCNH was associated with increased risk of glioma and acoustic neuroma. The MDM2 Ex12+162A>G variant was associated with significantly reduced risk of glioma. Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways. (Cancer Epidemiol Biomarkers Prev 2007; 16(8):1655-61) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Rajaraman, Preetha AU - Wang, Sophia S AU - Rothman, Nathaniel AU - Brown, Merideth M AU - Black, Peter M AU - Fine, Howard A AU - Loeffler, Jay S AU - Selker, Robert G AU - Shapiro, William R AU - Chanock, Stephen J AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, Neuro-oncology Branch, and Pediatric Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1655 EP - 1661 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 8 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Apoptosis KW - Gene polymorphism KW - Cell cycle KW - PTEN protein KW - Neoplasia KW - glioma KW - risk reduction KW - Haplotypes KW - prevention KW - Glioma KW - brain tumors KW - Bioindicators KW - MDM2 protein KW - Etiology KW - Data processing KW - haplotypes KW - biomarkers KW - Cancer KW - p53 protein KW - Brain tumors KW - Single-nucleotide polymorphism KW - France, Aquitaine, Oraas KW - meningioma KW - N3 11023:Neurogenetics KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+in+Apoptosis+and+Cell+Cycle+Control+Genes+and+Risk+of+Brain+Tumors+in+Adults&rft.au=Rajaraman%2C+Preetha%3BWang%2C+Sophia+S%3BRothman%2C+Nathaniel%3BBrown%2C+Merideth+M%3BBlack%2C+Peter+M%3BFine%2C+Howard+A%3BLoeffler%2C+Jay+S%3BSelker%2C+Robert+G%3BShapiro%2C+William+R%3BChanock%2C+Stephen+J%3BInskip%2C+Peter+D&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2007-08-01&rft.volume=16&rft.issue=8&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Etiology; Data processing; Apoptosis; Gene polymorphism; Cell cycle; PTEN protein; biomarkers; Neoplasia; p53 protein; Brain tumors; Haplotypes; Single-nucleotide polymorphism; Glioma; meningioma; Bioindicators; risk reduction; glioma; prevention; haplotypes; brain tumors; Cancer; France, Aquitaine, Oraas ER - TY - JOUR T1 - Phage passage after extended processing in small-virus-retentive filters AN - 20700483; 7566324 AB - Retention of a two small phages (X-174 and pp7) by direct-flow small-virus-retentive filters [Viresolve NFP (normal-flow parvovims), Virosart CPV (canine parvo-virus), Ultipor DV20 and Planova 20N] was studied using a commercial-process fluid. Phage passage occurred in each filter type, particularly when overloaded with phage. Clearances of pp7 and X-174 were similar for any given filter brand, arguing that the two phages are equivalent for testing small-virus-retentive filters. The patterns of flux under constant pressure and instantaneous LRV (log reduction value) in relationship to cumulative phage load differed between brands, consistent with the current industry understanding that each brand possesses specific performance attributes. Phages are a powerful and universal tool for evaluating filter performance. Validation of filter performance with phages such as pp7 or X-174 as models for small mammalian viruses represents an attractive alternative to the current practice. JF - Biotechnology and Applied Biochemistry AU - Lute, S AU - Bailey, M AU - Combs, J AU - Sukumar, M AU - Brorson, K AD - Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, kurt.brorson@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 141 EP - 151 PB - Portland Press Ltd., 59 Portland Place London W1N 3AJ UK, [mailto:sales@portlandpress.co.uk] VL - 47 IS - 3-4 SN - 0885-4513, 0885-4513 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Phages KW - Filters KW - Training KW - Pressure KW - Models KW - W 30925:Genetic Engineering KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20700483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Applied+Biochemistry&rft.atitle=Phage+passage+after+extended+processing+in+small-virus-retentive+filters&rft.au=Lute%2C+S%3BBailey%2C+M%3BCombs%2C+J%3BSukumar%2C+M%3BBrorson%2C+K&rft.aulast=Lute&rft.aufirst=S&rft.date=2007-08-01&rft.volume=47&rft.issue=3-4&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Applied+Biochemistry&rft.issn=08854513&rft_id=info:doi/10.1042%2FBA20060254 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Filters; Phages; Training; Pressure; Models DO - http://dx.doi.org/10.1042/BA20060254 ER - TY - JOUR T1 - A field investigation of manual forces associated with trigger and push to start electric screwdrivers AN - 20477994; 7961047 AB - This study investigated manual forces associated with trigger start (TS) and push to start (PTS) activation in-line electric screwdriver designs. The vertically directed axial screwdriver force transmitted with the driver to the fastener and the grip/finger forces on the driver handle were measured from 13 employees in an electronics assembly manufacturing facility. The PTS driver was associated with significantly ( p < .01) higher axial force than the TS driver at two of the four workstations, where the difference was as high as a 184% increase (36.5 vs. 103.8 N). Total finger force on the screwdriver handle was also higher for the PTS screwdriver ( p < .01). The PTS screwdriver may reduce instances of fastener head damage (cam out) by requiring a minimum level of axial force to ensure better contact between the screwdriver bit and the fastener. However, this appears to come at the expense of greater manual forces exerted by the operator. JF - Human Factors and Ergonomics in Manufacturing AU - Lowe, Brian D AU - Kong, Yong-Ku AU - Krieg, Edward AU - Wurzelbacher, Steven AU - Lee, Soo-Jin AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA, blowe@cdc.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 367 EP - 382 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 17 IS - 4 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Manufacturing industry KW - Human factors KW - Ergonomics KW - hand tools KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20477994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Impact+of+Systems+Toxicology+on+the+3Rs&rft.au=Fuscoe%2C+James+C&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Manufacturing industry; Human factors; hand tools; Ergonomics DO - http://dx.doi.org/10.1002/hfm.20079 ER - TY - JOUR T1 - A synthetic polypeptide based on human E-cadherin inhibits invasion of human intestinal and liver cell lines by Listeria monocytogenes AN - 20468858; 7647626 AB - Internalin A is a surface protein of the facultative intracellular pathogen Listeria monocytogenes that interacts with the human host cell protein E-cadherin to facilitate invasion of epithelial cells. A single amino acid substitution at position 16 in mouse E-cadherin prevents this interaction. Synthetic polypeptides of 30 aa encompassing position 16 of human and mouse E-cadherin were tested for their ability to inhibit in vitro invasion of Caco-2, HepG2 and TIB73 cell lines by L monocytogenes. Only the human-derived peptide was capable of inhibiting invasion in the human-origin Caco-2 and HepG2 cell lines. These findings demonstrate that small polypeptides can inhibit invasion of biologically relevant cell types by L monocytogenes in vitro and may be potentially useful as therapeutic agents in vivo. JF - Journal of Medical Microbiology AU - Sahu, S C AU - Gaines, D W AU - Williams, K M AU - Raybourne, R B AD - Immunobiology Branch, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, USA, richard.raybourne@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1011 EP - 1016 VL - 56 IS - 8 SN - 0022-2615, 0022-2615 KW - Microbiology Abstracts B: Bacteriology KW - Listeria monocytogenes KW - Epithelial cells KW - internalin KW - Amino acid substitution KW - Hepatocytes KW - E- double prime Cadherin KW - Intestine KW - Pathogens KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Microbiology&rft.atitle=A+synthetic+polypeptide+based+on+human+E-cadherin+inhibits+invasion+of+human+intestinal+and+liver+cell+lines+by+Listeria+monocytogenes&rft.au=Sahu%2C+S+C%3BGaines%2C+D+W%3BWilliams%2C+K+M%3BRaybourne%2C+R+B&rft.aulast=Sahu&rft.aufirst=S&rft.date=2007-08-01&rft.volume=56&rft.issue=8&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Microbiology&rft.issn=00222615&rft_id=info:doi/10.1099%2Fjmm.0.47194-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Amino acid substitution; internalin; Hepatocytes; E- double prime Cadherin; Intestine; Pathogens; Listeria monocytogenes DO - http://dx.doi.org/10.1099/jmm.0.47194-0 ER - TY - JOUR T1 - A Community Outbreak of Campylobacter Jejuni Infection from a Chlorinated Public Water Supply AN - 20364145; 7663155 AB - An outbreak of Campylobacter jejuni infection occurred in a South Wales Valleys housing estate. Illness in estate residents was associated with tap water consumption [population attributable risk (PAR) 50%, relative risk (RR) 2.53, 95% confidence interval (CI) 1.9-3.37] and residence in the upper estate (PAR 49%, RR 2.44, 95% CI 1.83-3.24). Amongst upper estate residents, rates of diarrhoeal illness increased with rates of water consumption (OR 18, 95% CI 3.5-92.4 for heaviest consumers, X sub(2) trend P<0.0001). The upper estate received mains water via a covered holding reservoir. A crack in the wall of the holding reservoir was identified. Contamination with surface water from nearby pasture land was the likely cause of this outbreak. Service reservoirs are common in rural communities and need regular maintenance and inspection. The role of water in sporadic cases of campylobacter enteritis may be underestimated. (Accepted December 16 2006) (Online publication February 09 2007) JF - Epidemiology and Infection AU - Richardson, G AU - Thomas, DRh AU - Smith, RMM AU - Nehaul, L AU - Ribeiro, C D AU - Brown, A G AU - Salmon, R L AD - National Public Health Service, Communicable Disease Surveillance Centre, Cardiff, UK Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1151 EP - 1158 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 135 IS - 7 SN - 0950-2688, 0950-2688 KW - Risk Abstracts; Aqualine Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Pollution Abstracts KW - Risk assessment KW - Housing KW - Contamination KW - Surface water KW - Surface Water KW - inspection KW - Infection KW - Pasture KW - Water supplies KW - Drinking Water KW - Campylobacter jejuni KW - Water-borne diseases KW - infection KW - Consumers KW - Reservoirs KW - water use KW - British Isles, Wales, South Wales KW - valleys KW - Enteritis KW - Publications KW - outbreaks KW - Maintenance KW - Risk KW - Inspection KW - Drinking water KW - H 12000:Epidemiology and Public Health KW - AQ 00005:Underground Services and Water Use KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20364145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=A+Community+Outbreak+of+Campylobacter+Jejuni+Infection+from+a+Chlorinated+Public+Water+Supply&rft.au=Richardson%2C+G%3BThomas%2C+DRh%3BSmith%2C+RMM%3BNehaul%2C+L%3BRibeiro%2C+C+D%3BBrown%2C+A+G%3BSalmon%2C+R+L&rft.aulast=Richardson&rft.aufirst=G&rft.date=2007-08-01&rft.volume=135&rft.issue=7&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268807007960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Contamination; Housing; Surface water; Enteritis; Consumers; Infection; Water supplies; Pasture; water use; valleys; infection; Water-borne diseases; outbreaks; Drinking water; inspection; Maintenance; Risk; Drinking Water; Surface Water; Publications; Inspection; Reservoirs; Campylobacter jejuni; British Isles, Wales, South Wales DO - http://dx.doi.org/10.1017/S0950268807007960 ER - TY - JOUR T1 - Estimation of sound pressure level exposures from sound power level measurements of powered hand-tools AN - 20329500; 7646439 AB - As part of a long-term goal to reduce noise-induced hearing loss in the construction industry, the National Institute for Occupational Safety and Health (NIOSH) estimated the A-weighted sound pressure level at the operator's ear (L sub(pA,est)) from the A-weighted sound power (L sub(wa)) measurements of 118 various model powered hand tools using the diffuse-field point source model Eyring theory. L sub(pA,est) from the model are compared to sound pressure measurements (L sub(pA,meas)) acquired from a microphone located in the nominal hearing zone of a simulated powered hand tool operator. This paper provides a basis for the direct substitution of L sub(WA) for L sub(pA,meas) and a comparison of L sub(pA,est), to L sub(pA,meas). The magnitude of L sub(WA) is found to be a reasonable predictor of the magnitude of sound pressure level exposure, or L sub(pA,meas), that a powered hand tool operator might experience across a variety of acoustical environments. As such, L sub(WA) can be used directly to select appropriate hearing protection and estimate worker' noise exposure. L sub(WA) can be measured for all power tools with appropriate loading conditions; however, measuring the sound pressure levels for all combinations of powered hand tools and acoustical environments in the construction industry is not feasible. Purchasers and users of those tools deserve a viable method of estimating noise exposure. JF - Noise Control Engineering Journal AU - Hayden, C S AU - Zechmann, EL AD - NIOSH, 4676 Columbia Parkway C27, Cincinnati OH 45226, USA, CHayden@cdc.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 379 EP - 389 VL - 55 IS - 4 SN - 0736-2501, 0736-2501 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Noise levels KW - Hearing loss KW - hand tools KW - Construction industry KW - Occupational exposure KW - Sound pressure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20329500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=Estimation+of+sound+pressure+level+exposures+from+sound+power+level+measurements+of+powered+hand-tools&rft.au=Hayden%2C+C+S%3BZechmann%2C+EL&rft.aulast=Hayden&rft.aufirst=C&rft.date=2007-08-01&rft.volume=55&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Noise levels; Hearing loss; Occupational exposure; Construction industry; hand tools; Sound pressure ER - TY - JOUR T1 - Pulmonary Toxicity of Expancel(R) Microspheres in the Rat AN - 20320687; 7692090 AB - Expancel(R) microspheres are thermoplastic microspheres enclosing hydrocarbon. These microspheres expand when heated, producing many applications. Because they have unknown biological persistence and toxicity, we investigated the toxicity of two unexpanded (11.1 and 15.4 is a subset of m mean diameter) and two expanded (3.1 and 5.5 is a subset of m mass median aerodynamic diameter) Expancel® microspheres in intratracheally-instilled, male, Sprague-Dawley rats. Pulmonary histopathology was evaluated at 28 days postexposure. Bronchoalveolar lavage fluid was evaluated at days 1, 7, 14, and 28 days postexposure. Crystalline silica was the positive control. By histopathology, both unexpanded and expanded microspheres caused granulomatous bronchopneumonia characterized by macrophages and giants cells, suggesting a persistent foreign body response. Expanded, but not unexpanded microspheres, also caused eosinophilic bronchitis and bronchiolitis, mucous metaplasia of airways and organized granulomatous inflammation with associated fibrosis and frequent airway obstruction. In contrast, alveolar macrophage activation, polymorphonuclear leukocytes, LDH and albumin in bronchoalveolar laveage fluid were initially elevated but returned to near control levels at 28 days, and did not reflect the persistent granulomatous bronchopneumonia caused by Expancel® microspheres. These findings emphasize the importance of histopathology for evaluating pulmonary toxicity, suggest that Expancel® microspheres are a potential occupational hazard, and indicate a need for additional studies on their potential pulmonary toxicity. [Supplementary materials are available for this article. Go to the publisher's online edition of Toxicology Pathology for the following free supplemental resources: motion within unexpected microspheres in H&E-stained lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)]. JF - Toxicologic Pathology AU - Porter, Dale W AU - Hubbs, Ann F AU - Baron, Paul A AU - Millecchia, Lyndell L AU - Wolfarth, Michael G AU - Battelli, Lori A AU - Schwegler-Berry, Diane E AU - Beighley, Christopher M AU - Andrew, Michael E AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 702 EP - 714 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 35 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Macrophages KW - Giant cells KW - Membrane ruffling KW - Hydrocarbons KW - Fibrosis KW - Leukocytes (polymorphonuclear) KW - Toxicity KW - Alveoli KW - Cell activation KW - Inflammation KW - Silica KW - Bronchus KW - Lung KW - Metaplasia KW - Occupational hazards KW - Albumin KW - microspheres KW - Bronchitis KW - Epithelium KW - Phagocytosis KW - Foreign bodies KW - Bronchopneumonia KW - Respiratory tract KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20320687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Pulmonary+Toxicity+of+Expancel%28R%29+Microspheres+in+the+Rat&rft.au=Porter%2C+Dale+W%3BHubbs%2C+Ann+F%3BBaron%2C+Paul+A%3BMillecchia%2C+Lyndell+L%3BWolfarth%2C+Michael+G%3BBattelli%2C+Lori+A%3BSchwegler-Berry%2C+Diane+E%3BBeighley%2C+Christopher+M%3BAndrew%2C+Michael+E%3BCastranova%2C+Vincent&rft.aulast=Porter&rft.aufirst=Dale&rft.date=2007-08-01&rft.volume=35&rft.issue=5&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701481915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Giant cells; Macrophages; Fibrosis; Hydrocarbons; Membrane ruffling; Leukocytes (polymorphonuclear); Toxicity; Alveoli; Inflammation; Cell activation; Silica; Bronchus; Lung; Metaplasia; Albumin; Occupational hazards; microspheres; Epithelium; Bronchitis; Phagocytosis; Foreign bodies; Bronchopneumonia; Respiratory tract DO - http://dx.doi.org/10.1080/01926230701481915 ER - TY - JOUR T1 - Thrombocytopenia: Case definition and guidelines for collection, analysis, and presentation of immunization safety data AN - 20307993; 7640909 AB - Disclaimer: The findings, opinions, and assertions contained in this consensus document are those of the individual scientific professional members of the Working Group. They do not necessarily represent the official positions of each participant's organization (e.g., government, university, or corporation). Specifically, the findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Food and Drug Administration.Corresponding author at: University Children's Hospital, Basel, Switzerland. Tel.: +41 61 6856565.1Currently employed by Eli Lilly and Company, Indianapolis, IN, USA.2Brighton Collaboration homepage: http://www.brightoncollaboration.org. JF - Vaccine AU - Wise, Robert P AU - Bonhoeffer, Jan AU - Beeler, Judy AU - Donato, Hugo AU - Downie, Peter AU - Matthews, Dana AU - Pool, Vitali AU - Riise-Bergsaker, Marianne AU - Tapiainen, Terhi AU - Varricchio, Frederick AD - Food and Drug Administration, Rockville, MD, USA, secretariat@brightoncollaboration.org Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 5717 EP - 5724 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 31 SN - 0264-410X, 0264-410X KW - thrombocytopenia KW - Health & Safety Science Abstracts; Immunology Abstracts KW - Thrombocytopenia KW - Adverse event KW - Immunization KW - Guidelines KW - Case definition KW - vaccines KW - Food KW - Disease control KW - disease control KW - Children KW - immunization KW - guidelines KW - prevention KW - Drugs KW - Hospitals KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20307993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Thrombocytopenia%3A+Case+definition+and+guidelines+for+collection%2C+analysis%2C+and+presentation+of+immunization+safety+data&rft.au=Wise%2C+Robert+P%3BBonhoeffer%2C+Jan%3BBeeler%2C+Judy%3BDonato%2C+Hugo%3BDownie%2C+Peter%3BMatthews%2C+Dana%3BPool%2C+Vitali%3BRiise-Bergsaker%2C+Marianne%3BTapiainen%2C+Terhi%3BVarricchio%2C+Frederick&rft.aulast=Wise&rft.aufirst=Robert&rft.date=2007-08-01&rft.volume=25&rft.issue=31&rft.spage=5717&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.02.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Thrombocytopenia; Food; Disease control; Children; Drugs; Immunization; Hospitals; immunization; vaccines; guidelines; prevention; disease control DO - http://dx.doi.org/10.1016/j.vaccine.2007.02.067 ER - TY - JOUR T1 - Influence of Mycobacterium avium subsp. paratuberculosis on Colitis Development and Specific Immune Responses during Disease AN - 20303548; 7530462 AB - The granulomatous and intramural inflammation observed in cases of inflammatory bowel diseases (IBD) and veterinary Johne's disease suggests that Mycobacterium avium subsp. paratuberculosis is a causative agent. However, an incomplete understanding of the immunological steps responsible for the pathologies of IBD makes this conclusion uncertain. Sera from interleukin-10-deficient (IL-10 super(-/-)) mice with spontaneous colitis displayed significantly higher M. avium subsp. paratuberculosis-specific immunoglobulin G2a antibody responses than did sera from similar mice without disease. Pathogen-free IL-10 super(-/-) mice received control vehicle or the vehicle containing heat-killed or live M. avium subsp. paratuberculosis. Mucosal CD4 super(+) T cells from the mice that developed colitis proliferated and secreted higher levels of gamma interferon and tumor necrosis factor alpha after ex vivo stimulation with a V{szligbeta}11 super(+) T-cell receptor-restricted peptide from the MPT59 antigen (Ag85B) than those secreted from cells from mice before the onset of colitis. The data from this study provide important information regarding the mechanisms of colitis in IL-10 super(-/-) mice, which are driven in part by Ag85B-specific T cells. The data suggest a plausible mechanism of Ag-specific T-cell responses in colitis driven by potent Ags conserved in Mycobacterium species. JF - Infection and Immunity AU - Singh, Udai P AU - Singh, Shailesh AU - Singh, Rajesh AU - Karls, Russell K AU - Quinn, Frederick D AU - Potter, Morris E AU - Lillard, James WJr AD - Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia. Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia. Center for Food Safety and Applied Nutrition, Food and Drug Administration, Atlanta, Georgia Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3722 EP - 3728 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - CD4 antigen KW - Mycobacterium avium KW - Inflammatory bowel diseases KW - Paratuberculosis KW - Mucosa KW - Lymphocytes T KW - Immunoglobulin G KW - Tumor necrosis factor- alpha KW - Colitis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20303548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Influence+of+Mycobacterium+avium+subsp.+paratuberculosis+on+Colitis+Development+and+Specific+Immune+Responses+during+Disease&rft.au=Singh%2C+Udai+P%3BSingh%2C+Shailesh%3BSingh%2C+Rajesh%3BKarls%2C+Russell+K%3BQuinn%2C+Frederick+D%3BPotter%2C+Morris+E%3BLillard%2C+James+WJr&rft.aulast=Singh&rft.aufirst=Udai&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=3722&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; CD4 antigen; Inflammatory bowel diseases; Mucosa; Paratuberculosis; Immunoglobulin G; Lymphocytes T; Tumor necrosis factor- alpha; Colitis; Mycobacterium avium ER - TY - JOUR T1 - Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates AN - 20302787; 7640983 AB - Previously, we identified several attenuating mutations in the L polymerase protein of human parainfluenza virus type 2 (HPIV2) and genetically stabilized those mutations using reverse genetics [Nolan SM, Surman S, Amaro-Carambot E, Collins PL, Murphy BR, Skiadopoulos MH. Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses. Vaccine 2005; 39(23):4765-74]. Here we describe the discovery of an attenuating mutation at nucleotide 15 (15T->C) in the 3' genomic promoter that was also present in the previously characterized mutants. We evaluated the properties of this promoter mutation alone and in various combinations with the L polymerase mutations. Amino acid substitutions at L protein positions 460 (460A or 460P) or 948 (948L), or deletion of amino acids 1724 and 1725 ( Delta 1724), each conferred a temperature sensitivity (ts) phenotype whereas the 15T->C mutation did not. The 460A and 948L mutations each contributed to restricted replication in the lower respiratory tract of African green monkeys, but the Delta 1724 mutation increased attenuation only in certain combinations with other mutations. We constructed two highly attenuated viruses, rV94(15C)/460A/948L and rV94(15C)/948L/ Delta 1724, that were immunogenic and protective against challenge with wild-type HPIV2 in African green monkeys and, therefore, appear to be suitable for evaluation in humans. JF - Vaccine AU - Nolan, Sheila M AU - Skiadopoulos, Mario H AU - Bradley, Konrad AU - Kim, Olivia S AU - Bier, Stacia AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Davis, Stephanie AU - Claire, Marisa St AU - Elkins, Randy AU - Collins, Peter L AU - Murphy, Brian R AU - Schaap-Nutt, Anne AD - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, schaapa@niaid.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 6409 EP - 6422 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 34 SN - 0264-410X, 0264-410X KW - Primates KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human parainfluenza virus KW - Live attenuated vaccine candidates KW - Non-human primate study KW - Temperature effects KW - double prime L protein KW - Amino acid substitution KW - Replication KW - Nucleotides KW - Parainfluenza virus KW - Parainfluenza KW - Promoters KW - Gene deletion KW - Immunogenicity KW - genomics KW - Vaccines KW - Mutation KW - Respiratory tract KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Recombinant+human+parainfluenza+virus+type+2+vaccine+candidates+containing+a+3%27+genomic+promoter+mutation+and+L+polymerase+mutations+are+attenuated+and+protective+in+non-human+primates&rft.au=Nolan%2C+Sheila+M%3BSkiadopoulos%2C+Mario+H%3BBradley%2C+Konrad%3BKim%2C+Olivia+S%3BBier%2C+Stacia%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BDavis%2C+Stephanie%3BClaire%2C+Marisa+St%3BElkins%2C+Randy%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSchaap-Nutt%2C+Anne&rft.aulast=Nolan&rft.aufirst=Sheila&rft.date=2007-08-01&rft.volume=25&rft.issue=34&rft.spage=6409&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; double prime L protein; Amino acid substitution; Replication; Nucleotides; Parainfluenza; Promoters; Gene deletion; Immunogenicity; Vaccines; genomics; Mutation; Respiratory tract; Primates; Parainfluenza virus DO - http://dx.doi.org/10.1016/j.vaccine.2007.06.028 ER - TY - JOUR T1 - Core-linked LPS expression of Shigella dysenteriae serotype 1 O-antigen in live Salmonella Typhi vaccine vector Ty21a: Preclinical evidence of immunogenicity and protection AN - 20301772; 7640953 AB - Shigella dysenteriae serotype 1 (S. dysenteriae 1) causes severe shigellosis that is typically associated with high mortality. Antibodies against Shigella serotype-specific O-polysaccharide (O-Ps) have been shown to be host protective. In this study, the rfb locus and the rfp gene with their cognate promoter regions were PCR-amplified from S. dysenteriae 1, cloned, and sequenced. Deletion analysis showed that eight rfb ORFs plus rfp are necessary for biosynthesis of this O-Ps. A tandemly-linked rfb-rfp gene cassette was cloned into low copy plasmid pGB2 to create pSd1. Avirulent Salmonella enterica serovar Typhi (S. Typhi) Ty21a harboring pSd1 synthesized S. Typhi 9, 12 LPS as well as typical core-linked S. dysenteriae 1 LPS. Animal immunization studies showed that Ty21a (pSd1) induces protective immunity against high stringency challenge with virulent S. dysenteriae 1 strain 1617. These data further demonstrate the utility of S. Typhi Ty21a as a live, bacterial vaccine delivery system for heterologous O-antigens, supporting the promise of a bifunctional oral vaccine for prevention of shigellosis and typhoid fever. JF - Vaccine AU - Xu, De Qi AU - Cisar, John O AU - Osorio, Manuel AU - Wai, Tint T AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, FDA-CBER, Bethesda, MD 20892, United States, dennis.kopecko@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 6167 EP - 6175 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 33 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bifunctional vaccine KW - Oral vaccine KW - Typhoid-Shigella vaccine KW - Heterologous LPS expression KW - Shigella dysenteriae 1 KW - Salmonella Typhi Ty21a KW - Live bacterial vector KW - Mortality KW - Serotypes KW - Salmonella typhi KW - Shigella KW - Immunity KW - Plasmids KW - Immunization KW - Shigella dysenteriae KW - Expression vectors KW - Promoters KW - Antibodies KW - Immunogenicity KW - Shigellosis KW - Salmonella enterica KW - Lipopolysaccharides KW - Vaccines KW - Typhoid fever KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Core-linked+LPS+expression+of+Shigella+dysenteriae+serotype+1+O-antigen+in+live+Salmonella+Typhi+vaccine+vector+Ty21a%3A+Preclinical+evidence+of+immunogenicity+and+protection&rft.au=Xu%2C+De+Qi%3BCisar%2C+John+O%3BOsorio%2C+Manuel%3BWai%2C+Tint+T%3BKopecko%2C+Dennis+J&rft.aulast=Xu&rft.aufirst=De&rft.date=2007-08-01&rft.volume=25&rft.issue=33&rft.spage=6167&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Serotypes; Immunity; Plasmids; Immunization; Expression vectors; Promoters; Antibodies; Shigellosis; Immunogenicity; Lipopolysaccharides; Vaccines; Typhoid fever; Salmonella typhi; Salmonella enterica; Shigella; Shigella dysenteriae DO - http://dx.doi.org/10.1016/j.vaccine.2007.06.003 ER - TY - JOUR T1 - Rapid and widespread dissemination of multidrug-resistant bla sub(CMY-2) Salmonella Typhimurium in Mexico AN - 20299574; 7530557 AB - OBJECTIVES: We describe the emergence and dissemination of multidrug-resistant (MDR) Salmonella Typhimurium in humans, retail meat and food animals from Yucatan, Mexico. METHODS: Salmonella Typhimurium isolates were collected through an active surveillance system and tested for susceptibility to 12 antimicrobial agents. Isolates that were non-susceptible to ceftriaxone were tested with 10 additional antimicrobials and assayed by PCR for the presence of CMY, CTX-M, SHV, TEM and OXA {szligbeta}-lactamase genes. Plasmid-borne phenotypes were identified by transfer to susceptible Escherichia coli. Isolates from humans, retail meat and food animals were compared by PFGE to determine genetic relatedness. RESULTS: MDR Salmonella Typhimurium containing a plasmid-mediated bla sub(CMY-2) AmpC {szligbeta}-lactamase rose from 0% (0/27) during 2000 and 2001 to 75% (63/84) in 2004 and 2005 (P < 0.0001). MDR bla sub(CMY-2) Salmonella Typhimurium (n = 115) was most common in ill children (44.3%) and pork or swine intestine (36.5%). In several cities, MDR bla sub(CMY-2) Salmonella Typhimurium from retail meat or swine intestine exhibited PFGE patterns and antibiograms indistinguishable from those in strains recovered from hospitalized children. The CMY gene was transferred to E. coli by electroporation, along with resistance to three to six other antimicrobials. Children with MDR bla sub(CMY-2) Salmonella Typhimurium infection (n = 39) had a higher frequency of systemic infection (13% versus 0%), mortality (8% versus 0%) and hospital re-admission due to protracted diarrhoea (28% versus 17%) than children with non-MDR-Salmonella Typhimurium (n = 24), although the difference was not statistically significant. CONCLUSIONS: The rapid and widespread dissemination of MDR bla sub(CMY-2) Salmonella Typhimurium in Mexico calls for urgent interventions to contain this potentially fatal pathogen. JF - Journal of Antimicrobial Chemotherapy AU - Zaidi, Mussaret B AU - Leon, Veronica AU - Canche, Claudia AU - Perez, Carolina AU - Zhao, Shaohua AU - Hubert, Susannah K AU - Abbott, Jason AU - Blickenstaff, Karen AU - McDermott, Patrick F AD - Depto. de Investigacion, Laboratorio de Investigacion, Hospital General O'Horan, Av. Itzaes x Jacinto Canek, Merida C.P. 97000, Yucatan, Mexico. Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 398 EP - 401 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 2 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Diarrhea KW - Electroporation KW - Food KW - Disseminated infection KW - Pork KW - Statistical analysis KW - Pathogens KW - Ceftriaxone KW - Salmonella typhimurium KW - Children KW - Antimicrobial agents KW - Meat KW - Escherichia coli KW - Intestine KW - Polymerase chain reaction KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20299574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Rapid+and+widespread+dissemination+of+multidrug-resistant+bla+sub%28CMY-2%29+Salmonella+Typhimurium+in+Mexico&rft.au=Zaidi%2C+Mussaret+B%3BLeon%2C+Veronica%3BCanche%2C+Claudia%3BPerez%2C+Carolina%3BZhao%2C+Shaohua%3BHubert%2C+Susannah+K%3BAbbott%2C+Jason%3BBlickenstaff%2C+Karen%3BMcDermott%2C+Patrick+F&rft.aulast=Zaidi&rft.aufirst=Mussaret&rft.date=2007-08-01&rft.volume=60&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Diarrhea; Electroporation; Food; Disseminated infection; Statistical analysis; Pork; Ceftriaxone; Pathogens; Children; Antimicrobial agents; Meat; Intestine; Polymerase chain reaction; Hospitals; Escherichia coli; Salmonella typhimurium ER - TY - JOUR T1 - Toll-Like Receptor 2-Mediated Signaling Requirements for Francisella tularensis Live Vaccine Strain Infection of Murine Macrophages AN - 20298806; 7530505 AB - Francisella tularensis, an aerobic, non-spore-forming, gram-negative coccobacillus, is the causative agent of tularemia. We reported previously that F. tularensis live vaccine strain (LVS) elicited strong, dose-dependent NF- Kappa B reporter activity in Toll-like receptor 2 (TLR2)-expressing HEK293T cells and proinflammatory gene expression in primary murine macrophages. Herein, we report that F. tularensis LVS-induced murine macrophage proinflammatory cytokine gene and protein expression are overwhelmingly TLR2 dependent, as evidenced by the abrogated responses of TLR2 super(-/-) macrophages. F. tularensis LVS infection also increased expression of TLR2 both in vitro, in mouse macrophages, and in vivo, in livers from F. tularensis LVS-infected mice. Colocalization of intracellular F. tularensis LVS, TLR2, and MyD88 was visualized by confocal microscopy. Signaling was abrogated if the F. tularensis LVS organisms were heat or formalin killed or treated with chloramphenicol, indicating that the TLR2 agonist activity is dependent on new bacterial protein synthesis. F. tularensis LVS replicates in macrophages; however, bacterial replication was not required for TLR2 signaling because LVS Delta guaA, an F. tularensis LVS guanine auxotroph that fails to replicate in the absence of exogenous guanine, activated NF- Kappa B in TLR2-transfected HEK293T cells and induced cytokine expression in wild-type macrophages comparably to wild-type F. tularensis LVS. Collectively, these data indicate that the primary macrophage response to F. tularensis LVS is overwhelmingly TLR2 dependent, requires de novo bacterial protein synthesis, and is independent of intracellular F. tularensis replication. JF - Infection and Immunity AU - Cole, Leah E AU - Shirey, Kari Ann AU - Barry, Eileen AU - Santiago, Araceli AU - Rallabhandi, Prasad AU - Elkins, Karen L AU - Puche, Adam C AU - Michalek, Suzanne M AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology. Center for Vaccine Development. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, CBER, Food and Drug Administration, Bethesda, Maryland 20852. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 4127 EP - 4137 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Chloramphenicol KW - Protein biosynthesis KW - Replication KW - Auxotrophs KW - MyD88 protein KW - TLR2 protein KW - Formaldehyde KW - Francisella tularensis KW - Infection KW - Inflammation KW - NF- Kappa B protein KW - Gene expression KW - Tularemia KW - Guanine KW - Heat KW - Confocal microscopy KW - Liver KW - Cytokines KW - Vaccines KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20298806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Toll-Like+Receptor+2-Mediated+Signaling+Requirements+for+Francisella+tularensis+Live+Vaccine+Strain+Infection+of+Murine+Macrophages&rft.au=Cole%2C+Leah+E%3BShirey%2C+Kari+Ann%3BBarry%2C+Eileen%3BSantiago%2C+Araceli%3BRallabhandi%2C+Prasad%3BElkins%2C+Karen+L%3BPuche%2C+Adam+C%3BMichalek%2C+Suzanne+M%3BVogel%2C+Stefanie+N&rft.aulast=Cole&rft.aufirst=Leah&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=4127&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Chloramphenicol; Protein biosynthesis; MyD88 protein; Auxotrophs; Replication; TLR2 protein; Formaldehyde; Infection; NF- Kappa B protein; Inflammation; Gene expression; Guanine; Tularemia; Heat; Confocal microscopy; Liver; Cytokines; Vaccines; Toll-like receptors; Signal transduction; Francisella tularensis ER - TY - JOUR T1 - The Large Clostridial Toxins from Clostridium sordellii and C. difficile Repress Glucocorticoid Receptor Activity AN - 20297720; 7530484 AB - We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay system for GR transactivation. We also report that C. sordellii lethal toxin inhibited GR function in an ex vivo assay, where toxin reduced the dexamethasone suppression of the proinflammatory cytokine tumor necrosis factor alpha (TNF- alpha ). Furthermore, the glucocorticoid antagonist RU-486 in combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF- alpha . These findings corroborate the fact that GR is a target for the toxin and suggest a physiological role for toxin-associated GR repression in inflammation. Finally, we show that this repression is associated with toxins that inactivate p38 mitogen-activated protein kinase (MAPK). JF - Infection and Immunity AU - Tait, ASasha AU - Dalton, Monique AU - Geny, Blandine AU - D'Agnillo, Felice AU - Popoff, Michel R AU - Sternberg, Esther M AD - Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, Rockville, Maryland. Unite des Bacteries Anaerobes et Toxines, Institut Pasteur, Paris, France. Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3935 EP - 3940 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Dexamethasone KW - MAP kinase KW - Glucocorticoid receptors KW - Clostridium sordellii KW - Transfection KW - Cytokines KW - Tumor necrosis factor- alpha KW - Bacillus anthracis KW - Glucocorticoids KW - Toxins KW - Inflammation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20297720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Large+Clostridial+Toxins+from+Clostridium+sordellii+and+C.+difficile+Repress+Glucocorticoid+Receptor+Activity&rft.au=Tait%2C+ASasha%3BDalton%2C+Monique%3BGeny%2C+Blandine%3BD%27Agnillo%2C+Felice%3BPopoff%2C+Michel+R%3BSternberg%2C+Esther+M&rft.aulast=Tait&rft.aufirst=ASasha&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=3935&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Dexamethasone; MAP kinase; Glucocorticoid receptors; Transfection; Cytokines; Tumor necrosis factor- alpha; Glucocorticoids; Toxins; Inflammation; Clostridium sordellii; Bacillus anthracis ER - TY - JOUR T1 - Development and Validation of DNA Microarray for Genotyping Group A Rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) Genes AN - 20091633; 7558216 AB - Previously, we reported the development of a microarray-based method for the identification of five clinically relevant G genotypes (G1 to G4 and G9) (V. Chizhikov et al., J. Clin. Microbiol. 40:2398-2407, 2002). The expanded version of the rotavirus microarray assay presented herein is capable of identifying (i) five clinically relevant human rotavirus VP4 genotypes (P[4], P[6], P[8], P[9], and P[14]) and (ii) five additional human rotavirus VP7 genotypes (G5, G6, G8, G10, and G12) on one chip. Initially, a total of 80 cell culture-adapted human and animal reference rotavirus strains of known P (P[1] to P[12], P[14], P[16], and P[20]) and G (G1-6, G8 to G12, and G14) genotypes isolated in various parts of the world were employed to evaluate the new microarray assay. All rotavirus strains bearing P[4], P[6], P[8], P[9], or P[14] and/or G1 to G6, G8 to G10, or G12 specificity were identified correctly. In addition, cross-reactivity to viruses of genotype G11, G13, or G14 or P[1] to P[3], P[5], P[7], P[10] to P[12], P[16], or P[20] was not observed. Next, we analyzed a total of 128 rotavirus-positive human stool samples collected in three countries (Brazil, Ghana, and the United States) by this assay and validated its usefulness. The results of this study showed that the assay was sensitive and specific and capable of unambiguously discriminating mixed rotavirus infections from nonspecific cross-reactivity; the inability to discriminate mixed infections from nonspecific cross-reactivity is one of the inherent shortcomings of traditional multiplex reverse transcription-PCR genotyping. Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses. JF - Journal of Clinical Microbiology AU - Honma, Shinjiro AU - Chizhikov, Vladimir AU - Santos, Norma AU - Tatsumi, Masatoshi AU - do Carmo S. T. Timenetsky, Maria AU - Linhares, Alexandre C AU - Mascarenhas, Joana D'Arc P AU - Ushijima, Hiroshi AU - Armah, George E AU - Gentsch, Jon R AU - Hoshino, Yasutaka AD - Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janerio, Brazil. Instituto Adolfo Lutz, Sao Paulo, Brazil. Instituto Evandro Chagas, Secretaria de Vigilancia em Saude, Belem, Brazil. University of Tokyo, Tokyo, Japan. University of Ghana, Legon, Ghana. Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2641 EP - 2648 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 8 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Rotavirus KW - Cross-reactivity KW - Human rotavirus KW - Genotyping KW - Gene polymorphism KW - Genotypes KW - Feces KW - Group a rotavirus KW - DNA microarrays KW - Mixed infection KW - W 30910:Imaging KW - V 22300:Methods KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Development+and+Validation+of+DNA+Microarray+for+Genotyping+Group+A+Rotavirus+VP4+%28P%5B4%5D%2C+P%5B6%5D%2C+P%5B8%5D%2C+P%5B9%5D%2C+and+P%5B14%5D%29+and+VP7+%28G1+to+G6%2C+G8+to+G10%2C+and+G12%29+Genes&rft.au=Honma%2C+Shinjiro%3BChizhikov%2C+Vladimir%3BSantos%2C+Norma%3BTatsumi%2C+Masatoshi%3Bdo+Carmo+S.+T.+Timenetsky%2C+Maria%3BLinhares%2C+Alexandre+C%3BMascarenhas%2C+Joana+D%27Arc+P%3BUshijima%2C+Hiroshi%3BArmah%2C+George+E%3BGentsch%2C+Jon+R%3BHoshino%2C+Yasutaka&rft.aulast=Honma&rft.aufirst=Shinjiro&rft.date=2007-08-01&rft.volume=45&rft.issue=8&rft.spage=2641&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cross-reactivity; Gene polymorphism; Genotyping; Genotypes; Feces; DNA microarrays; Mixed infection; Rotavirus; Human rotavirus; Group a rotavirus ER - TY - JOUR T1 - Significance analysis of groups of genes in expression profiling studies AN - 20043296; 7609323 AB - MOTIVATION: Gene class testing (GCT) is a statistical approach to determine whether some functionally predefined classes of genes express differently under two experimental conditions. GCT computes the P-value of each gene class based on the null distribution and the gene classes are ranked for importance in accordance with their P-values. Currently, two null hypotheses have been considered: the Q1 hypothesis tests the relative strength of association with the phenotypes among the gene classes, and the Q2 hypothesis assesses the statistical significance. These two hypotheses are related but not equivalent. METHOD: We investigate three one-sided and two two-sided test statistics under Q1 and Q2. The null distributions of gene classes under Q1 are generated by permuting gene labels and the null distributions under Q2 are generated by permuting samples. RESULTS: We applied the five statistics to a diabetes dataset with 143 gene classes and to a breast cancer dataset with 508 GO (Gene Ontology) terms. In each statistic, the null distributions of the gene classes under Q1 are different from those under Q2 in both datasets, and their rankings can be different too. We clarify the one-sided and two-sided hypotheses, and discuss some issues regarding the Q1 and Q2 hypotheses for gene class ranking in the GCT. Because Q1 does not deal with correlations among genes, we prefer test based on Q2. CONTACT: jchenatnctr.fda.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Chen, James J AU - Lee, Taewon AU - Delongchamp, Robert R AU - Chen, Tao AU - Tsai, Chen-An AD - Division of Personalized Nutrition and Medicine, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA Institute of Statistical Science, Academia Sinica, Taipei, Taiwan and Biostatistics Center, China Medical University, Taichung, Taiwan Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2104 EP - 2112 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 16 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Diabetes mellitus KW - Statistics KW - Data processing KW - Statistical analysis KW - Breast cancer KW - Bioinformatics KW - double prime GO gene KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20043296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Significance+analysis+of+groups+of+genes+in+expression+profiling+studies&rft.au=Chen%2C+James+J%3BLee%2C+Taewon%3BDelongchamp%2C+Robert+R%3BChen%2C+Tao%3BTsai%2C+Chen-An&rft.aulast=Chen&rft.aufirst=James&rft.date=2007-08-01&rft.volume=23&rft.issue=16&rft.spage=2104&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Data processing; Statistics; Statistical analysis; Breast cancer; Bioinformatics; double prime GO gene ER - TY - JOUR T1 - Occurrence of Listeria monocytogenes in Sandwiches Available to Hospital Patients in Wales, United Kingdom AN - 20033550; 7652946 AB - A survey for the presence of Listeria monocytogenes in hospital sandwiches was carried out in Wales, United Kingdom, between October 2005 and March 2006. The main aim of the survey was to establish the baseline rate of L. monocytogenes in hospital sandwiches after an outbreak of listeriosis among hospital patients in 2004 was epidemiologically linked to the consumption of contaminated sandwiches. The overall positive rate found in hospital sandwiches was 2.84% for enriched culture and 0.21% for direct counts. The unsatisfactory rate (>100 CFU/g) for hospital sandwiches was 0.1%. The conclusion was that hospital sandwiches generally presented a low hazard to consumers. In addition to establishing the overall baseline and the unsatisfactory rates in hospital sandwiches in Wales for this period, the study compared the rates found in hospital sandwiches with the rates found in sandwiches simultaneously sampled from general retailers. The aim of this part of the study was to compare the relative rates associated with hospital and retail sandwiches to ascertain if there were any differences in the positive rate. The conclusion of this part of the survey was that there was not a statistically significant difference in rates between sandwiches sampled from hospitals and those sampled from general retailers. JF - Journal of Food Protection AU - Meldrum, R J AU - Smith, RMM AD - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1958 EP - 1960 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 70 IS - 8 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Listeria monocytogenes KW - Listeriosis KW - Colony-forming cells KW - Statistical analysis KW - Consumers KW - outbreaks KW - Food contamination KW - British Isles, Wales KW - Hospitals KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20033550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Occurrence+of+Listeria+monocytogenes+in+Sandwiches+Available+to+Hospital+Patients+in+Wales%2C+United+Kingdom&rft.au=Meldrum%2C+R+J%3BSmith%2C+RMM&rft.aulast=Meldrum&rft.aufirst=R&rft.date=2007-08-01&rft.volume=70&rft.issue=8&rft.spage=1958&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282007%290702.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Listeriosis; Colony-forming cells; Statistical analysis; Consumers; Hospitals; outbreaks; Food contamination; Listeria monocytogenes; British Isles, Wales DO - http://dx.doi.org/10.1043/0362-028X(2007)070[1958:RNOOMI]2.3.CO;2 ER - TY - JOUR T1 - The identification of antibacterial compounds for the development of enhanced media for the detection of foodborne fungi AN - 19985550; 7585117 AB - In an effort to identify a more suitable antibiotic for utilization in mycological media, 12 food borne fungal species from various genera including Alternaria alternata, Aspergillus flavus, A. niger, Eurotium chevalieri, Fusarium moniliforme, Penicillium sp., Rhizopus stolonifer, Saccharomyces cerevisiae, Candida tropicalis, Geotrichum candidum, Rhodotorula glutinis and Kluyveromyces thermotolerans along with 21 chloramphenicol-resistant bacterial isolates from fresh produce and ATCC cultures of Pseudomonas aeruginosa, P. fluorescens, E. coli, Pectobacterium carotovorum, Bacillus cereus and Staphylococcus spp. were tested for their abilities to grow on dichloran rose bengal agar containing various levels of gentamicin, chlortetracycline or chloramphenicol. Results indicated that all fungal isolates except for Rh. glutinis and R. stolonifer grew well on all media tested. Rh. glutinis did not grow on media containing gentamicin whereas R. stolonifer produced very restricted or no growth on these media. All bacterial isolates from fresh produce, P. aeruginosa (ATCC 27853) and P. fluorescens (ATCC BAA-477) grew well at 100, 125 and 150mg chloramphenicol/liter medium, but they did not grow on media containing chlortetracycline (100, 125, or 150mg/L) or gentamicin (15, 25, or 35mg/L). P. aeruginosa (ATCC 10145) grew well on media containing chloramphenicol or gentamicin, but not in the presence of chlortetracycline. P. carotovorum, E. coli, B. cereus and Staphylococcus spp. did not grow on any of the selective media tested. JF - International Journal of Food Microbiology AU - Tournas, V H AU - Kohn, J S AU - Katsoudas, E J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA, valerie.tournas@fda.hhs.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 83 EP - 86 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 118 IS - 1 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Chloramphenicol KW - Chlortetracycline KW - Gentamicin KW - Bacterial and fungal resistance KW - Agar KW - Kluyveromyces thermotolerans KW - Aspergillus flavus KW - Penicillium KW - Food KW - Bacillus cereus KW - Antibiotics KW - Alternaria alternata KW - Geotrichum candidum KW - Pectobacterium KW - Escherichia coli KW - Eurotium chevalieri KW - Rhizopus stolonifer KW - Pseudomonas aeruginosa KW - Rhodotorula glutinis KW - Fungi KW - Staphylococcus KW - Media (selective) KW - Saccharomyces cerevisiae KW - Fusarium moniliforme KW - Candida tropicalis KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19985550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=The+identification+of+antibacterial+compounds+for+the+development+of+enhanced+media+for+the+detection+of+foodborne+fungi&rft.au=Tournas%2C+V+H%3BKohn%2C+J+S%3BKatsoudas%2C+E+J&rft.aulast=Tournas&rft.aufirst=V&rft.date=2007-08-01&rft.volume=118&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2007.04.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gentamicin; Agar; Chloramphenicol; Chlortetracycline; Fungi; Food; Antibiotics; Media (selective); Kluyveromyces thermotolerans; Aspergillus flavus; Penicillium; Staphylococcus; Bacillus cereus; Alternaria alternata; Saccharomyces cerevisiae; Fusarium moniliforme; Geotrichum candidum; Pectobacterium; Escherichia coli; Candida tropicalis; Eurotium chevalieri; Pseudomonas aeruginosa; Rhizopus stolonifer; Rhodotorula glutinis DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2007.04.013 ER - TY - JOUR T1 - FDA Drug Approval Summary: Pegaspargase (Oncaspar registered ) for the First-Line Treatment of Children with Acute Lymphoblastic Leukemia (ALL) AN - 19779517; 7561054 AB - On July 24, 2006, the U.S. Food and Drug Administration granted approval to pegaspargase (Oncaspar registered ; Enzon Pharmaceuticals, Inc., Bridgewater, NJ; hereafter, O) for the first-line treatment of patients with acute lymphoblastic leukemia (ALL) as a component of a multiagent chemotherapy regimen. O was previously approved in February 1994 for the treatment of patients with ALL who were hypersensitive to native forms of L-asparaginase. The trial supporting this new indication was an open label, randomized, multicenter clinical trial that enrolled 118 children (age, 1-9 years) with previously untreated, standard risk ALL. Patients received either native Escherichia coli asparaginase (Elspar registered ; Merck, Whitehouse Station, NJ; hereafter, E) or O along with multiagent chemotherapy during remission induction and delayed intensification (DI) phases of treatment. O, at a dose of 2,500 IU/m super(2), was administered i.m. on day 3 of the 4-week induction phase and on day 3 of each of two 8-week DI phases. E, at a dose of 6,000 IU/m super(2), was administered i.m. three times weekly for nine doses during induction and for six doses during each DI phase. This study allowed direct comparison of O and E for asparagine depletion, asparaginase activity, and development of asparaginase antibodies. An unplanned comparison of event-free survival (EFS) was conducted to rule out a deleterious O efficacy effect. Following induction and DI treatment there was complete ( less than or equal to 1 mu M) or moderate (1-10 mu M) depletion of serum asparagine levels in the large majority of samples tested over the 4-week period in both O-treated and E-treated subjects. Similarly, depletion of cerebrospinal fluid asparagine levels during induction was similar between O-treated and E-treated subjects. The number of days asparaginase activity exceeded >0.03 IU/ml in O-treated subjects was greater than the number of days in E-treated subjects during both the induction and DI phases of treatment. There was no correlation, however, between asparaginase activity and serum asparagine levels, making the former determination less clinically relevant. Using the protocol-prespecified threshold for a positive result of >2.5 times the control, 7 of 56 (12%) O subjects tested at any time during the study demonstrated antiasparaginase antibodies and 16 of 57 (28%) E subjects tested at any time during the study had antiasparaginase antibodies. In both study arms EFS was in the range of 80% at 3 years. The most serious, sometimes fatal, O toxicities were anaphylaxis, other serious allergic reactions, thrombosis (including sagittal sinus thrombosis), pancreatitis, glucose intolerance, and coagulopathy. The most common adverse events were allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases. Disclosure of potential conflicts of interest is found at the end of this article. JF - Oncologist AU - Dinndorf, Patricia Anne AU - Gootenberg, Joseph AU - Cohen, Martin H AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 991 EP - 998 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 12 IS - 8 SN - 1083-7159, 1083-7159 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Central nervous system KW - Age KW - Anaphylaxis KW - Chemotherapy KW - Survival KW - Clinical trials KW - Asparagine KW - transaminase KW - Hypersensitivity KW - Cerebrospinal fluid KW - Hyperglycemia KW - Acute lymphatic leukemia KW - Hyperbilirubinemia KW - Escherichia coli KW - Asparaginase KW - Remission KW - Sinus KW - Toxicity KW - L-asparaginase KW - Children KW - Thrombosis KW - Antibodies KW - Pharmaceuticals KW - Glucose tolerance KW - Pancreatitis KW - F 06915:Cancer Immunology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19779517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=FDA+Drug+Approval+Summary%3A+Pegaspargase+%28Oncaspar+registered+%29+for+the+First-Line+Treatment+of+Children+with+Acute+Lymphoblastic+Leukemia+%28ALL%29&rft.au=Dinndorf%2C+Patricia+Anne%3BGootenberg%2C+Joseph%3BCohen%2C+Martin+H%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Dinndorf&rft.aufirst=Patricia&rft.date=2007-08-01&rft.volume=12&rft.issue=8&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Asparaginase; Central nervous system; Age; Anaphylaxis; Chemotherapy; Survival; Remission; Sinus; L-asparaginase; Toxicity; Children; Asparagine; Clinical trials; transaminase; Thrombosis; Cerebrospinal fluid; Antibodies; Hypersensitivity; Hyperglycemia; Hyperbilirubinemia; Acute lymphatic leukemia; Glucose tolerance; Pharmaceuticals; Pancreatitis; Escherichia coli ER - TY - JOUR T1 - Comparative Mortality for 621 Second Cancers in 29356 Testicular Cancer Survivors and 12420 Matched First Cancers AN - 19743285; 7558835 AB - BACKGROUND: Testicular cancer survivors, many of whom have undergone radiotherapy, are at substantial risk of second cancers. Treatment for testicular cancer may limit treatment options for second cancers, thereby adversely affecting survival after the second cancer. However, no data on outcomes of testicular cancer survivors with second cancers compared to patients with comparable first cancers exist. METHODS: Among 29356 white testicular cancer patients reported to the Surveillance, Epidemiology, and End Results (SEER) program (1973-2002), 621 developed a second cancer with known stage and were matched to a random sample of 12420 white male first cancer patients in the SEER program by cancer site, stage, diagnosis year, and age at diagnosis. Mortality was ascertained through 2002. Cancer-specific and all-cause mortality following second cancers were compared with those of matched first cancers, and rate ratios (RRs) were estimated using proportional hazards analysis. Survival functions were calculated using product-limit estimates. RESULTS: During the study period, 284 testicular cancer survivors with second cancers died, 191 from their second cancer; 5443 matched first cancer patients died, 3929 from their first cancer. Rate ratios for cancer-specific and all-cause mortality for second cancers compared with matched first cancers were 1.05 (95% confidence interval [CI] = 0.90 to 1.23) and 1.09 (95% CI = 0.96 to 1.23), respectively. However, among testicular cancer patients who were diagnosed during 1973-1979, an era in which radiation therapy was given at high doses and to the chest area, all-cause mortality following second cancers at sites below the diaphragm (79 deaths) and second lung cancers (29 deaths) was statistically significantly higher than that from matched first cancers (RR = 1.44, 95% CI = 1.13 to 1.83, and RR = 1.65, 95% CI = 1.12 to 2.42, respectively). CONCLUSIONS: Mortality from second cancers following testicular cancer was similar to matched first cancers, except for selected tumors in the radiotherapy field among testicular cancer patients who were diagnosed during 1973-1979, a time when radiotherapy doses for treatment of testicular cancer were high and chest irradiation was an option in standard practice. JF - Journal of the National Cancer Institute AU - Schairer, Catherine AU - Hisada, Michie AU - Chen, Bingshu E AU - Brown, Linda M AU - Howard, Regan AU - Fossaa, Sophie D AU - Gail, Mitchell AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (CS, MH, BEC, LMB, RH, MG, LBT) Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1248 EP - 1256 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 16 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Radiation therapy KW - Mortality KW - survival KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19743285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Comparative+Mortality+for+621+Second+Cancers+in+29356+Testicular+Cancer+Survivors+and+12420+Matched+First+Cancers&rft.au=Schairer%2C+Catherine%3BHisada%2C+Michie%3BChen%2C+Bingshu+E%3BBrown%2C+Linda+M%3BHoward%2C+Regan%3BFossaa%2C+Sophie+D%3BGail%2C+Mitchell%3BTravis%2C+Lois+B&rft.aulast=Schairer&rft.aufirst=Catherine&rft.date=2007-08-01&rft.volume=99&rft.issue=16&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Radiation therapy; Mortality; survival; Lung cancer ER - TY - JOUR T1 - Salmonella and Campylobacter in United Kingdom Retail Raw Chicken in 2005 AN - 19456078; 7652942 AB - The United Kingdom Food Standards Agency commissioned a survey of Salmonella and Campylobacter in raw, whole chickens at retail in Wales and Northern Ireland between March and December 2005 to measure the baseline prevalence rates of these two significant pathogens. In total, 877 retail samples were examined for Campylobacter and Salmonella by enrichment methods. Overall contamination rates of 70.2% for Campylobacter and 4.0% for Salmonella were found. There was a statistically significant difference in Campylobacter rates between fresh and frozen samples, with fresh samples having a higher rate. There was no statistically significant difference between samples taken from retailers and butchers. Campylobacter was significantly more common in Northern Ireland than in Wales. Salmonella was significantly more common in Wales. The findings indicate the need for further investigation to explore why measures that have been successful in reducing Salmonella in the United Kingdom in recent years have failed to contribute to the control of Campylobacter. Identifying the factors responsible could lead to the introduction of more effective controls throughout the industry. JF - Journal of Food Protection AU - Meldrum, Richard J AU - Wilson, Ian G AD - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, UK Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1937 EP - 1939 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 70 IS - 8 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Poultry KW - Food KW - British Isles, Northern Ireland KW - Statistical analysis KW - Campylobacter KW - Pathogens KW - Food contamination KW - Salmonella KW - British Isles, Wales KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Salmonella+and+Campylobacter+in+United+Kingdom+Retail+Raw+Chicken+in+2005&rft.au=Meldrum%2C+Richard+J%3BWilson%2C+Ian+G&rft.aulast=Meldrum&rft.aufirst=Richard&rft.date=2007-08-01&rft.volume=70&rft.issue=8&rft.spage=1937&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282007%290702.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Food; Statistical analysis; Pathogens; Food contamination; Poultry; Campylobacter; Salmonella; British Isles, Northern Ireland; British Isles, Wales DO - http://dx.doi.org/10.1043/0362-028X(2007)070[1937:RNAIUK]2.3.CO;2 ER - TY - RPRT T1 - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. [Part 2 of 2] T2 - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. AN - 756824416; 12872-070329_0002 AB - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.). JF - EPA number: 070329, 722 pages, July 30, 2007 PY - 2007 VL - 2 KW - Land Use KW - Buildings KW - Farmlands KW - Forests KW - Health Hazard Analyses KW - Health Hazards KW - Noise KW - Research Facilities KW - Safety KW - Safety Analyses KW - Wetlands KW - Ohio KW - Federal Water Pollution Control Act of 1972, Section 404 Permits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.title=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: July 30, 2007 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. [Part 1 of 2] T2 - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. AN - 756824382; 12872-070329_0001 AB - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.). JF - EPA number: 070329, 722 pages, July 30, 2007 PY - 2007 VL - 1 KW - Land Use KW - Buildings KW - Farmlands KW - Forests KW - Health Hazard Analyses KW - Health Hazards KW - Noise KW - Research Facilities KW - Safety KW - Safety Analyses KW - Wetlands KW - Ohio KW - Federal Water Pollution Control Act of 1972, Section 404 Permits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.title=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: July 30, 2007 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. AN - 36343617; 12872 AB - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.). JF - EPA number: 070329, 722 pages, July 30, 2007 PY - 2007 KW - Land Use KW - Buildings KW - Farmlands KW - Forests KW - Health Hazard Analyses KW - Health Hazards KW - Noise KW - Research Facilities KW - Safety KW - Safety Analyses KW - Wetlands KW - Ohio KW - Federal Water Pollution Control Act of 1972, Section 404 Permits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36343617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.title=NATIONAL+INSTITUTE+FOR+OCCUPATIONAL+SAFETY+AND+HEALTH+%28NIOSH%29+CINCINNATI+LABORATORY+CONSOLIDATION%2C+HAMILTON+AND+CLERMONT+COUNTIES%2C+OHIO.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: July 30, 2007 N1 - Last updated - 2011-12-16 ER - TY - CPAPER T1 - The U.S. Perspective on the Global Strategy for Diet, Physical Activity and Health T2 - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AN - 39426545; 4599467 JF - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AU - Schneeman, Barbara O Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - USA KW - Physical activity KW - Diets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39426545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.atitle=The+U.S.+Perspective+on+the+Global+Strategy+for+Diet%2C+Physical+Activity+and+Health&rft.au=Schneeman%2C+Barbara+O&rft.aulast=Schneeman&rft.aufirst=Barbara&rft.date=2007-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - When is a New Dietary Supplement Reasonably Expected to be Safe? T2 - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AN - 39356493; 4599440 JF - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AU - Frankos, Vasilios Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.atitle=When+is+a+New+Dietary+Supplement+Reasonably+Expected+to+be+Safe%3F&rft.au=Frankos%2C+Vasilios&rft.aulast=Frankos&rft.aufirst=Vasilios&rft.date=2007-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scientific Evidence for Making Health Claims on Foods and Food Ingredients T2 - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AN - 39345860; 4599713 JF - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AU - Kavanaugh, C Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Application+of+allometric+principles+for+the+prediction+of+pharmacokinetics+in+human+and+veterinary+drug+development&rft.au=Mahmood%2C+Iftekhar&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2007-09-01&rft.volume=59&rft.issue=11&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.05.015 L2 - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Survival of Francisella tularensis in Various Beverages T2 - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AN - 39338946; 4598616 JF - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007) AU - Laird, David T AU - Stewart, Diana AU - Reineke, Karl AU - Tortorello, Mary Lou Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - Survival KW - Beverages KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39338946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.atitle=Comparison+of+Survival+of+Francisella+tularensis+in+Various+Beverages&rft.au=Laird%2C+David+T%3BStewart%2C+Diana%3BReineke%2C+Karl%3BTortorello%2C+Mary+Lou&rft.aulast=Laird&rft.aufirst=David&rft.date=2007-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists+%28IFT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - National Ambulatory Medical Care Survey: terrorism preparedness among office-based physicians, United States, 2003-2004. AN - 68174803; 17702147 AB - This investigation describes terrorism preparedness among U.S. office-based physicians and their staffs in identification and diagnosis of terrorism-related conditions, training methods and sources, and assistance with diagnosis and reporting. The National Ambulatory Medical Care Survey (NAMCS) is an annual national probability survey of approximately 3,000 U.S. nonfederal, office-based physicians. Terrorism preparedness items were added in 2003 and 2004. About 40 percent of physicians or their staffs received training for anthrax or smallpox, but less than one-third received training for any of the other exposures. About 42.2 percent of physicians, 13.5 percent of nurses, and 9.4 percent of physician assistants and nurse practitioners received training in at least one exposure. Approximately 56.2 percent of physicians indicated that they would contact state or local public health officials for diagnostic assistance more frequently than federal agencies and other sources. About 67.1 percent of physicians indicated that they would report a suspected terrorism-related condition to the state or local health department, 50.9 percent to the Centers for Disease Control and Prevention (CDC), 27.5 percent to the local hospital, and 1.8 percent to a local elected official's office. Approximately 78.8 percent of physicians had contact information for the local health department readily available. About 53.7 percent had reviewed the diseases reportable to health departments since September 2001, 11.3 percent had reviewed them before that month, and 35 percent had never reviewed them. JF - Advance data AU - Niska, Richard W AU - Burt, Catharine W AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA. Y1 - 2007/07/24/ PY - 2007 DA - 2007 Jul 24 SP - 1 EP - 10 IS - 390 SN - 0147-3956, 0147-3956 KW - Health administration KW - United States KW - Teaching KW - Health Care Surveys KW - Humans KW - Ambulatory Care KW - Physicians' Offices KW - Chemical Terrorism KW - Disaster Planning KW - Bioterrorism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68174803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advance+data&rft.atitle=National+Ambulatory+Medical+Care+Survey%3A+terrorism+preparedness+among+office-based+physicians%2C+United+States%2C+2003-2004.&rft.au=Niska%2C+Richard+W%3BBurt%2C+Catharine+W&rft.aulast=Niska&rft.aufirst=Richard&rft.date=2007-07-24&rft.volume=&rft.issue=390&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Advance+data&rft.issn=01473956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-12 N1 - Date created - 2007-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of mobile radiographic screening on tuberculosis among drug users and homeless persons. AN - 70703610; 17413123 AB - In 2002, a mobile radiographic screening program was started in Rotterdam to respond to high rates of tuberculosis (TB) among illicit drug users and homeless persons. We studied trends and characteristics of TB among these risk groups and assessed the impact of the screening program on transmission, using molecular typing. Description of trends, and of demographic and disease-related characteristics of tuberculosis cases among these risk groups between 1993 and 2005. TB was considered to result from recent transmission if the mycobacterial DNA fingerprints of cases were identical to those of other cases in the risk groups in the previous 2 years. During the study period, 206 individuals with TB among illicit drug users and homeless persons were notified, representing 11.4% of the total case load of 1,811 in Rotterdam. The annual number of tuberculosis cases declined from 24 at the start of the screening program to 11 cases in 2005. The screening program identified 28 cases (a prevalence rate of 327 per 100,000 radiographs), of which 12 were smear positive. In 1997-2002, more than 80% of the illicit drug users or homeless persons with TB were infected with one of the Mycobacterium tuberculosis strains prevalent among these risk groups. After nearly 4 years of systematic radiographic screening this proportion declined to 45% in 2005. DNA fingerprinting can be a useful tool to evaluate the impact of a TB screening program. We advocate that screening of illicit drug users and homeless persons should be continued to prevent a resurgence of TB. JF - American journal of respiratory and critical care medicine AU - de Vries, Gerard AU - van Hest, Rob A H AU - Richardus, Jan H AD - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands. devriesg@ggd.rotterdam.nl Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 201 EP - 207 VL - 176 IS - 2 SN - 1073-449X, 1073-449X KW - Street Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Netherlands -- epidemiology KW - Humans KW - Child KW - DNA Fingerprinting KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Radiography KW - Adolescent KW - Cluster Analysis KW - Female KW - Male KW - Mass Screening KW - Tuberculosis, Pulmonary -- transmission KW - Substance-Related Disorders -- microbiology KW - Substance-Related Disorders -- diagnostic imaging KW - Tuberculosis, Pulmonary -- diagnostic imaging KW - Mobile Health Units KW - Tuberculosis, Pulmonary -- epidemiology KW - Homeless Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70703610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Impact+of+mobile+radiographic+screening+on+tuberculosis+among+drug+users+and+homeless+persons.&rft.au=de+Vries%2C+Gerard%3Bvan+Hest%2C+Rob+A+H%3BRichardus%2C+Jan+H&rft.aulast=de+Vries&rft.aufirst=Gerard&rft.date=2007-07-15&rft.volume=176&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Respir Crit Care Med. 2008 Mar 1;177(5):557-8 [18296473] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Attenuation and Efficacy of Human Parainfluenza Virus Type 1 (HPIV1) Vaccine Candidates Containing Stabilized Mutations in the P/C and L Genes. T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502073; 4677927 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bartlett, Emmalene J AU - Castano, Adam AU - Surman, Sonja R AU - Collins, Peter L AU - Skiadopoulos, Mario H AU - Murphy, Brian R Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mutation KW - Vaccines KW - Parainfluenza KW - Disease control KW - Parainfluenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Attenuation+and+Efficacy+of+Human+Parainfluenza+Virus+Type+1+%28HPIV1%29+Vaccine+Candidates+Containing+Stabilized+Mutations+in+the+P%2FC+and+L+Genes.&rft.au=Bartlett%2C+Emmalene+J%3BCastano%2C+Adam%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BSkiadopoulos%2C+Mario+H%3BMurphy%2C+Brian+R&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Influenza a Matrix Gene Mutant Protected Mice Against Both Homologous and Heterologous Wild Type Influenza Viruses T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39501757; 4677816 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Xie, Hang AU - Liu, Teresa AU - Ye, Zhiping Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Influenza KW - Mice KW - Mutants KW - Viruses KW - Influenza A KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39501757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=An+Influenza+a+Matrix+Gene+Mutant+Protected+Mice+Against+Both+Homologous+and+Heterologous+Wild+Type+Influenza+Viruses&rft.au=Xie%2C+Hang%3BLiu%2C+Teresa%3BYe%2C+Zhiping&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mumps Virus Strain-Specific Antibody Neutralization and Waning Immunity Following Vaccination T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39488096; 4677925 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Rubin, Steven AU - Li, Qi AU - Audet, Susette AU - Lebaron, Charles AU - Bellini, William AU - Rota, Paul AU - Carbone, Kathryn AU - Beeler, Judy Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Neutralization KW - Vaccination KW - Antibodies KW - Mumps KW - Immunity KW - Mumps virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39488096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Mumps+Virus+Strain-Specific+Antibody+Neutralization+and+Waning+Immunity+Following+Vaccination&rft.au=Rubin%2C+Steven%3BLi%2C+Qi%3BAudet%2C+Susette%3BLebaron%2C+Charles%3BBellini%2C+William%3BRota%2C+Paul%3BCarbone%2C+Kathryn%3BBeeler%2C+Judy&rft.aulast=Rubin&rft.aufirst=Steven&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Amino Acid Changes within the Mumps Virus Hemagglutinin-Neuraminidase, Fusion and Polymerase Proteins Affect Protein Function and are Associated with Reduced Neurovirulence. T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39415692; 4677309 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Malik, Tahir H AU - Wolbert, Candie AU - Mauldin, Jeremy AU - Sauder, Christian AU - Carbone, Kathryn M AU - Rubin, Steven A Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Amino acids KW - Mumps KW - Amino acid sequence KW - Neurovirulence KW - Mumps virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39415692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Single+Amino+Acid+Changes+within+the+Mumps+Virus+Hemagglutinin-Neuraminidase%2C+Fusion+and+Polymerase+Proteins+Affect+Protein+Function+and+are+Associated+with+Reduced+Neurovirulence.&rft.au=Malik%2C+Tahir+H%3BWolbert%2C+Candie%3BMauldin%2C+Jeremy%3BSauder%2C+Christian%3BCarbone%2C+Kathryn+M%3BRubin%2C+Steven+A&rft.aulast=Malik&rft.aufirst=Tahir&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action. AN - 70722121; 17620536 AB - Warfarin sodium is widely used and causes bleeding; a review might suggest the need for regulatory action by the US Food and Drug Administration (FDA). We accessed warfarin prescriptions from the National Prescription Audit Plus database of IMS Health (Plymouth Meeting, Pennsylvania), adverse event reports submitted to the FDA, deaths due to therapeutic use of anticoagulants from vital statistics data, and warfarin bleeding complications from national hospital emergency department data. The number of dispensed outpatient prescriptions for warfarin increased 45%, from 21 million in 1998 to nearly 31 million in 2004. The FDA's Adverse Event Reporting System indicated that warfarin is among the top 10 drugs with the largest number of serious adverse event reports submitted during the 1990 and 2000 decades. From US death certificates, anticoagulants ranked first in 2003 and 2004 in the number of total mentions of deaths for drugs causing "adverse effects in therapeutic use." Data from hospital emergency departments for 1999 through 2003 indicated that warfarin was associated with about 29 000 visits for bleeding complications per year, and it was among the drugs with the most visits. These data are consistent with literature reports of major bleeding frequencies for warfarin as high as 10% to 16%. Use of warfarin has increased, and bleeding from warfarin use is a prevalent reaction and an important cause of mortality. Consequently, a "black box" warning about warfarin's bleeding risk was added to the US product labeling in 2006. Physicians and nurses should tell patients to immediately report signs and symptoms of bleeding. A Medication Guide, which is required to be provided with each prescription, reinforces this message. JF - Archives of internal medicine AU - Wysowski, Diane K AU - Nourjah, Parivash AU - Swartz, Lynette AD - Division of Drug Risk Evaluation, Food and Drug Administration, White Oak, Bldg 22, Room 3424, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. diane.wysowski@fda.hhs.gov Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 SP - 1414 EP - 1419 VL - 167 IS - 13 SN - 0003-9926, 0003-9926 KW - Anticoagulants KW - 0 KW - Warfarin KW - 5Q7ZVV76EI KW - Abridged Index Medicus KW - Index Medicus KW - United States Food and Drug Administration KW - Drug and Narcotic Control KW - Humans KW - International Normalized Ratio KW - Death Certificates KW - United States -- epidemiology KW - Cause of Death KW - Drug Prescriptions -- statistics & numerical data KW - Hemorrhage -- epidemiology KW - Hemorrhage -- chemically induced KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70722121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Bleeding+complications+with+warfarin+use%3A+a+prevalent+adverse+effect+resulting+in+regulatory+action.&rft.au=Wysowski%2C+Diane+K%3BNourjah%2C+Parivash%3BSwartz%2C+Lynette&rft.aulast=Wysowski&rft.aufirst=Diane&rft.date=2007-07-09&rft.volume=167&rft.issue=13&rft.spage=1414&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Clin Pract Cardiovasc Med. 2008 Jan;5(1):14-5 [17940514] Arch Intern Med. 2008 Jan 28;168(2):236-7; author reply 237 [18227374] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Produce Time Temperature Control for Safety Where Do Lettuce and Leafy Greens Fits? T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39542791; 4647959 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Bohm, Shirley B Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Temperature effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39542791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Produce+Time+Temperature+Control+for+Safety+Where+Do+Lettuce+and+Leafy+Greens+Fits%3F&rft.au=Bohm%2C+Shirley+B&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancer Risk Estimation Derived from Studies of Nuclear Workers. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39496512; 4659301 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AU - Silver, Sharon R Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39496512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Cancer+Risk+Estimation+Derived+from+Studies+of+Nuclear+Workers.&rft.au=Howard%2C+George%3BLabarthe%2C+Darwin+R%3BHu%2C+Jianfang%3BYoon%2C+Sarah%3BHoward%2C+Virginia+J&rft.aulast=Howard&rft.aufirst=George&rft.date=2007-09-01&rft.volume=17&rft.issue=9&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ecological Problems in the Shallow Eutrophic Latvian Lakes T2 - Fifth Symposium for European Freshwater Sciences (SEFS 5) AN - 39475756; 4677056 JF - Fifth Symposium for European Freshwater Sciences (SEFS 5) AU - Balode, Maija AU - Barda, Ieva AU - Purina, Ingrida Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Eutrophication KW - Lakes KW - Eutrophic waters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39475756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+Symposium+for+European+Freshwater+Sciences+%28SEFS+5%29&rft.atitle=Ecological+Problems+in+the+Shallow+Eutrophic+Latvian+Lakes&rft.au=Balode%2C+Maija%3BBarda%2C+Ieva%3BPurina%2C+Ingrida&rft.aulast=Balode&rft.aufirst=Maija&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+Symposium+for+European+Freshwater+Sciences+%28SEFS+5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sefs5.it/Programme_1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Antimicrobial Resistance of Salmonella Isolated from Retail Meat: National Antimicrobial Resistance Monitoring System (NARMS): 20022005 T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39472866; 4647972 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Zhao, Shaohua AU - White, D G AU - Hall-Robinson, E AU - Ayers, L AU - Glenn, A AU - Friedman, S L AU - Abbott, J W AU - Harbottle, H AU - McDermott, P F Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Meat KW - Monitoring systems KW - Anadromous species KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39472866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Prevalence+and+Antimicrobial+Resistance+of+Salmonella+Isolated+from+Retail+Meat%3A+National+Antimicrobial+Resistance+Monitoring+System+%28NARMS%29%3A+20022005&rft.au=Zhao%2C+Shaohua%3BWhite%2C+D+G%3BHall-Robinson%2C+E%3BAyers%2C+L%3BGlenn%2C+A%3BFriedman%2C+S+L%3BAbbott%2C+J+W%3BHarbottle%2C+H%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=Shaohua&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Model for Assessing the Training Needs of Retail Food Safety Inspection Officers T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39464624; 4647598 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Tart, Alan M Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Inspection KW - Training KW - Food KW - Models KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39464624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=A+Model+for+Assessing+the+Training+Needs+of+Retail+Food+Safety+Inspection+Officers&rft.au=Tart%2C+Alan+M&rft.aulast=Tart&rft.aufirst=Alan&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Defense Research Activities at FDA-CFSAN T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39463076; 4647510 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Acheson, David Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39463076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Food+Defense+Research+Activities+at+FDA-CFSAN&rft.au=Acheson%2C+David&rft.aulast=Acheson&rft.aufirst=David&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Diversity of Salmonella enterica Serovar Weltevreden Isolates from Imported Seafood T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39462841; 4647555 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Ponce, Elizabeth AU - Khan, Ashaf AU - Cheng, Chorng-Ming AU - Summage, Christine AU - Cerniglia, Carl E Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Seafood KW - Genetic diversity KW - Anadromous species KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39462841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Genetic+Diversity+of+Salmonella+enterica+Serovar+Weltevreden+Isolates+from+Imported+Seafood&rft.au=Ponce%2C+Elizabeth%3BKhan%2C+Ashaf%3BCheng%2C+Chorng-Ming%3BSummage%2C+Christine%3BCerniglia%2C+Carl+E&rft.aulast=Ponce&rft.aufirst=Elizabeth&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recovery of Staphylococcal Enterotoxin in Multiple Phase Foods T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39456055; 4647949 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Bennett, Reginald W Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39456055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Emergence+of+a+Virulent+Clade+of+Vibrio+vulnificus+and+Correlation+with+the+Presence+of+a+33-Kilobase+Genomic+Island&rft.au=Cohen%2C+Ana+Luisa+V%3BOliver%2C+James+D%3BDePaola%2C+Angelo%3BFeil%2C+Edward+J%3BFidelma+Boyd%2C+E&rft.aulast=Cohen&rft.aufirst=Ana+Luisa&rft.date=2007-09-01&rft.volume=73&rft.issue=17&rft.spage=5553&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficiency of Transport Media for Recovery of Listeria from Milk Biofilm and Meat Processing Plant Environmental Swabs T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39455633; 4647822 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Reineke, Karl AU - Stewart, Diana AU - Tortorello, Mary Lou Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Milk KW - Biofilms KW - Meat KW - Media (transport) KW - Listeria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39455633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Efficiency+of+Transport+Media+for+Recovery+of+Listeria+from+Milk+Biofilm+and+Meat+Processing+Plant+Environmental+Swabs&rft.au=Reineke%2C+Karl%3BStewart%2C+Diana%3BTortorello%2C+Mary+Lou&rft.aulast=Reineke&rft.aufirst=Karl&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Molecular Characterization of Class 1 Integron Resistance Genes Cassettes among Salmonella Strains from Imported Seafood T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39454607; 4647998 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Khan, Ashaf A AU - Cheng, Chorng-Ming AU - Ponce, Elizabeth AU - Khan, Junaid A AU - West, Christine S Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Seafood KW - Anadromous species KW - Strains KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39454607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Identification+and+Molecular+Characterization+of+Class+1+Integron+Resistance+Genes+Cassettes+among+Salmonella+Strains+from+Imported+Seafood&rft.au=Khan%2C+Ashaf+A%3BCheng%2C+Chorng-Ming%3BPonce%2C+Elizabeth%3BKhan%2C+Junaid+A%3BWest%2C+Christine+S&rft.aulast=Khan&rft.aufirst=Ashaf&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Heat Treatment on the Quantitation of Peanut Allergens by ELISA Test Kits T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39451609; 4647941 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Fu, Tong-Jen AU - Maks, Nicole Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Allergens KW - ELISA KW - Heat treatments KW - Nuts KW - Quantitation KW - Arachis hypogaea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39451609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Effect+of+Heat+Treatment+on+the+Quantitation+of+Peanut+Allergens+by+ELISA+Test+Kits&rft.au=Fu%2C+Tong-Jen%3BMaks%2C+Nicole&rft.aulast=Fu&rft.aufirst=Tong-Jen&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Allergy Regulatory Update T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39450323; 4647729 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Harden, Elizabeth L Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Food hypersensitivity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39450323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Food+Allergy+Regulatory+Update&rft.au=Harden%2C+Elizabeth+L&rft.aulast=Harden&rft.aufirst=Elizabeth&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of the Combination of pH, Water Activity and Temperature on the Growth of Bacillus anthracis T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39449748; 4647981 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Hao, Yun-Yun D AU - Whiting, Richard C Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Temperature effects KW - PH KW - PH effects KW - Water temperature KW - Water activity KW - Abiotic factors KW - Growth KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39449748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Effect+of+the+Combination+of+pH%2C+Water+Activity+and+Temperature+on+the+Growth+of+Bacillus+anthracis&rft.au=Hao%2C+Yun-Yun+D%3BWhiting%2C+Richard+C&rft.aulast=Hao&rft.aufirst=Yun-Yun&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Other May 2007 Critical Decisions T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39440529; 4647624 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Sims, Steven Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Milk KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39440529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Other+May+2007+Critical+Decisions&rft.au=Sims%2C+Steven&rft.aulast=Sims&rft.aufirst=Steven&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarrays for Analysis and Detection of Microbial Pathogens and Their Toxins T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39440242; 4647962 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Rasooly, Avraham Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Pathogens KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39440242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Microarrays+for+Analysis+and+Detection+of+Microbial+Pathogens+and+Their+Toxins&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Safety Strategic Plan to Open Estuary T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39437121; 4647738 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Depaola, Angelo Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Estuaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39437121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=A+Safety+Strategic+Plan+to+Open+Estuary&rft.au=Depaola%2C+Angelo&rft.aulast=Depaola&rft.aufirst=Angelo&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asian Traditional Food Safety Case Study Georgia T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39432780; 4647851 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Livsey, Kimberly Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - USA, Georgia KW - Case studies KW - Food KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39432780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Asian+Traditional+Food+Safety+Case+Study+Georgia&rft.au=Livsey%2C+Kimberly&rft.aulast=Livsey&rft.aufirst=Kimberly&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing Risk Profiles to Assist Regulatory Decision Making T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39429227; 4648067 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Miliotis, Marianne AU - Dennis, Sherri AU - Buchanan, Robert AU - Hicks, John Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Decision making KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39429227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Developing+Risk+Profiles+to+Assist+Regulatory+Decision+Making&rft.au=Miliotis%2C+Marianne%3BDennis%2C+Sherri%3BBuchanan%2C+Robert%3BHicks%2C+John&rft.aulast=Miliotis&rft.aufirst=Marianne&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDAs Use of Epidemiologic Data, Traceback Investigations and Farm Investigations as Regulatory Tools during Outbreaks of Cyclospora cayetanensis Associated with Produce, 19952005 T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39428333; 4647756 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Timbo, Babgaleh B AU - Ross, Marianne P AU - Street, Debra A AU - Guzewich, Jack J Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Farms KW - Outbreaks KW - FDA KW - Cyclospora cayetanensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39428333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=FDAs+Use+of+Epidemiologic+Data%2C+Traceback+Investigations+and+Farm+Investigations+as+Regulatory+Tools+during+Outbreaks+of+Cyclospora+cayetanensis+Associated+with+Produce%2C+19952005&rft.au=Timbo%2C+Babgaleh+B%3BRoss%2C+Marianne+P%3BStreet%2C+Debra+A%3BGuzewich%2C+Jack+J&rft.aulast=Timbo&rft.aufirst=Babgaleh&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pasteurization Requirements for Dairy Products T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39411958; 4648063 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Larkin, John Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Dairy products KW - Pasteurization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39411958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Pasteurization+Requirements+for+Dairy+Products&rft.au=Larkin%2C+John&rft.aulast=Larkin&rft.aufirst=John&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outbreak Investigation: Different Agencies and Compelling Priorities T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39410175; 4647845 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Bohm, Shirley B Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Outbreaks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39410175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Outbreak+Investigation%3A+Different+Agencies+and+Compelling+Priorities&rft.au=Bohm%2C+Shirley+B&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survival of Bacillus anthracis Vegetative Cells in Beverages T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39404943; 4647887 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Hao, Yun-Yun D AU - Whiting, Richard C Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Survival KW - Vegetative cells KW - Beverages KW - Cell survival KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Survival+of+Bacillus+anthracis+Vegetative+Cells+in+Beverages&rft.au=Hao%2C+Yun-Yun+D%3BWhiting%2C+Richard+C&rft.aulast=Hao&rft.aufirst=Yun-Yun&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Real-time PCR with Conventional Culture for Detection of Yersinia enterocolitica in Environmental Swabs T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39404686; 4647802 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Stewart, Diana AU - Laird, David AU - Reineke, Karl AU - Tortorello, Mary Lou Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Polymerase chain reaction KW - Nucleotide sequence KW - Yersinia enterocolitica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ciencia+%26+saude+coletiva&rft.atitle=Ethical+and+scientific+issues+of+nanotechnology+in+the+workplace.&rft.au=Schulte%2C+Paul+A%3BSalamanca-Buentello%2C+Fabio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2007-09-01&rft.volume=12&rft.issue=5&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Ciencia+%26+saude+coletiva&rft.issn=1678-4561&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Determination of Three Macrolide Antibiotics in Foodstuffs by High-performance Liquid Chromatography T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39361608; 4647945 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Kim, Su-Ok AU - Bhan, K N AU - Lee, S H AU - Won, S Y AU - Lee, H J AU - Park, S W AU - Ok, H M AU - Kang, H I AU - Kim, S H AU - Kim, D B Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Antibiotics KW - Liquid chromatography KW - High-performance liquid chromatography KW - Food KW - Macrolide antibiotics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Simultaneous+Determination+of+Three+Macrolide+Antibiotics+in+Foodstuffs+by+High-performance+Liquid+Chromatography&rft.au=Kim%2C+Su-Ok%3BBhan%2C+K+N%3BLee%2C+S+H%3BWon%2C+S+Y%3BLee%2C+H+J%3BPark%2C+S+W%3BOk%2C+H+M%3BKang%2C+H+I%3BKim%2C+S+H%3BKim%2C+D+B&rft.aulast=Kim&rft.aufirst=Su-Ok&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Managing an Outbreak Investigation: The Role of an Enforcement Officer: Two Perspectives T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39361381; 4647847 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Bohm, Shirley B AU - Sprenger, Richard Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Outbreaks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Managing+an+Outbreak+Investigation%3A+The+Role+of+an+Enforcement+Officer%3A+Two+Perspectives&rft.au=Bohm%2C+Shirley+B%3BSprenger%2C+Richard&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Universal M13 Tailed Primers for Use in Sequencing PCR Products with Degenerative Primers or Short Amplicons T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39361294; 4647797 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Woods, Jacquelina W AU - Gonzalez-Escalona, Narjol AU - Burkhardt III, William Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Primers KW - Polymerase chain reaction KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Universal+M13+Tailed+Primers+for+Use+in+Sequencing+PCR+Products+with+Degenerative+Primers+or+Short+Amplicons&rft.au=Woods%2C+Jacquelina+W%3BGonzalez-Escalona%2C+Narjol%3BBurkhardt+III%2C+William&rft.aulast=Woods&rft.aufirst=Jacquelina&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Investigation of Carrot Juice Processor and Regulatory Response T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39352499; 4647501 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Zink, Donald Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Juices KW - Daucus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39352499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Environmental+Investigation+of+Carrot+Juice+Processor+and+Regulatory+Response&rft.au=Mishra%2C+Mark+V%3BSingh%2C+Anurag+K&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The dependence of time-domain speed-of-sound measurements on center frequency, bandwidth, and transit-time marker in human calcaneus in vitro. AN - 742772857; pmid-17614520 AB - Time-domain speed-of-sound (SOS) measurements in calcaneus are effective predictors of osteoporotic fracture risk. High attenuation and dispersion in bone, however, produce severe distortion of transmitted pulses that leads to ambiguity of time-domain SOS measurements. An equation to predict the effects of system parameters (center frequency and bandwidth), algorithm parameters (pulse arrival-time marker), and bone properties (attenuation coefficient and thickness) on time-domain SOS estimates is derived for media with attenuation that varies linearly with frequency. The equation is validated using data from a bone-mimicking phantom and from 30 human calcaneus samples in vitro. The data suggest that the effects of dispersion are small compared with the effects of frequency-dependent attenuation. The equation can be used to retroactively compensate data. System-related variations in SOS are shown to decrease as the pulse-arrival-time marker is moved toward the pulse center. Therefore, compared with other time-domain measures of SOS, group velocity exhibits the minimum system dependence. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-140, Rockville, Maryland 20852, USA. kaw@cdrh.fda.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 636 EP - 644 VL - 122 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Osteoporosis -- diagnosis KW - Computer Simulation KW - Reproducibility of Results KW - Ultrasonography -- instrumentation KW - Humans KW - Fractures, Bone -- etiology KW - Algorithms KW - Time Factors KW - Models, Biological KW - Male KW - Female KW - Osteoporosis -- complications KW - Phantoms, Imaging KW - Artifacts KW - Calcaneus -- ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742772857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=The+dependence+of+time-domain+speed-of-sound+measurements+on+center+frequency%2C+bandwidth%2C+and+transit-time+marker+in+human+calcaneus+in+vitro.&rft.au=Wear%2C+Keith+A&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2007-07-01&rft.volume=122&rft.issue=1&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Lack of evidence for contact sensitization by Pfiesteria extract. AN - 70726704; 17637917 AB - Members of the estuarine dinoflagellate genus Pfiesteria are reported to have been responsible for massive fish kills in the southeastern United States. Some reports suggest that exposure to waters having Pfiesteria blooms or occupation-related exposure might result in Pfiesteria-induced dermal irritation and inflammation. Although the toxin has not been isolated and purified, the original data suggested both hydrophilic and hydrophobic toxic components. Some investigators propose that dermonecrotic properties are associated with a hydrophobic fraction. A bioactive C18-bound putative toxin (CPE) extracted from Pfiesteria-laden aquarium water during active fish-killing conditions was examined in the present study to evaluate its potential to produce inflammation and dermal sensitization and to determine whether the inflammation and dermatitis reported in early human exposure studies were allergic or irritant in nature. This fraction was cytotoxic to mouse Neuro-2A cells and primary human epidermal keratinocytes (NHEK) at a concentration of 1 mg/mL. Balb/C mice exposed to 50-200% CPE by skin painting exhibited a 6-10% increase in ear swelling relative to vehicle-treated mice in a primary irritancy assay. There was no increase in lymph node cell proliferation as measured using the local lymph node assay. Exposure to CPE in culture up-regulated interleukin-8 in NHEK, whereas granulocyte macrophage-colony-stimulating factor and tumor necrosis factor alpha were only minimally altered. This study suggests that CPE is cytotoxic to keratinocytes in culture at high concentrations and that it induces mild, localized irritation but not dermal sensitization. JF - Environmental health perspectives AU - Patterson, Rachel M AU - Noga, Edward AU - Germolec, Dori AD - Toxicology Operations Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1023 EP - 1028 VL - 115 IS - 7 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Cell Line KW - Pfiesteria piscicida -- immunology KW - Dermatitis, Contact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Lack+of+evidence+for+contact+sensitization+by+Pfiesteria+extract.&rft.au=Patterson%2C+Rachel+M%3BNoga%2C+Edward%3BGermolec%2C+Dori&rft.aulast=Patterson&rft.aufirst=Rachel&rft.date=2007-07-01&rft.volume=115&rft.issue=7&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Jan 17;142(3):203-11 [10667891] Environ Health Perspect. 2006 Jul;114(7):1038-43 [16835056] J Toxicol Environ Health A. 2001 Aug 24;63(8):553-64 [11549115] Environ Health Perspect. 2001 Oct;109 Suppl 5:731-7 [11677182] Environ Health Perspect. 2001 Oct;109 Suppl 5:739-43 [11677183] Environ Health Perspect. 2001 Oct;109 Suppl 5:745-56 [11677184] Environ Health Perspect. 2001 Oct;109 Suppl 5:781-6 [11677189] Environ Health Perspect. 2001 Oct;109 Suppl 5:639-59 [11687383] Regul Toxicol Pharmacol. 2001 Dec;34(3):258-73 [11754530] Neurotoxicol Teratol. 2001 Nov-Dec;23(6):609-16 [11792529] Clin Exp Dermatol. 2002 Mar;27(2):138-46 [11952708] South Med J. 2002 Jul;95(7):720-6 [12144078] Food Chem Toxicol. 2002 Nov;40(11):1719-25 [12176099] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):10970-5 [12163648] Nature. 2002 Aug 29;418(6901):967-70 [12198545] Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6 [12426128] Neurotoxicol Teratol. 2003 Jul-Aug;25(4):419-26 [12798959] Toxicol In Vitro. 2004 Jun;18(3):231-43 [15046769] Nature. 1992 Jul 30;358(6385):407-10 [1641022] J Toxicol Environ Health. 1995 Dec;46(4):501-22 [8523474] Md Med J. 1997 Nov-Dec;46(10):521-3 [9392940] Environ Health Perspect. 1997 Dec;105(12):1320-5 [9405328] Md Med J. 1998 Feb-Mar;47(2):64-6 [9524412] Md Med J. 1998 May;47(3):124-6 [9601197] Md Med J. 1998 May;47(3):137-43 [9601201] Lancet. 1998 Aug 15;352(9127):532-9 [9716058] Sci Am. 1999 Aug;281(2):42-9 [10443037] Drug Chem Toxicol. 1999 Aug;22(3):491-506 [10445160] Appl Environ Microbiol. 2005 Jan;71(1):519-29 [15640229] Neurotoxicol Teratol. 2005 Sep-Oct;27(5):701-10 [16198085] J Immunol. 2000 Mar 15;164(6):3392-401 [10706735] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. AN - 70725176; 17637929 AB - Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity. We assessed the use of bloodborne MT transcript as a reflection of tissue MT levels and examined the potential role of MT in arsenic toxicity in an environmentally exposed human population. Rodents were treated with zinc or nonmetallic MT inducers for 4 days, and the blood and tissues were collected for MT transcript analysis by real-time reverse transcriptase-polymerase chain reaction and MT protein determination by the cadmium-hemoglobin assay. Blood and buccal cell samples were collected from arsenicosis patients and healthy subjects residing in Guizhou, China, and total RNA was isolated for MT transcript analysis. There was a positive correlation between blood MT-1 and MT-2 transcripts and corresponding hepatic or renal MT transcript levels in rats and mice. Furthermore, there was a positive correlation between blood MT-1 and MT-2 transcript and tissue MT protein levels in these animals. A positive correlation also occurred between human blood MT and buccal cell MT transcript levels. MT-1A and MT-2A were the major isoform transcripts in human blood and buccal cells, and significantly lower MT levels were seen in arsenicosis patients compared with healthy subjects. Blood MT transcript appears to be a useful biomarker of tissue MT levels. Arsenicosis patients in Guizhou show significantly lower MT transcript levels in blood, which may have predisposed this population to arsenic intoxication. JF - Environmental health perspectives AU - Liu, Jie AU - Cheng, Min-Liang AU - Yang, Qin AU - Shan, Ke-Ren AU - Shen, Jun AU - Zhou, Yushu AU - Zhang, Xinjiang AU - Dill, Anna L AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1101 EP - 1106 VL - 115 IS - 7 SN - 0091-6765, 0091-6765 KW - Biomarkers KW - 0 KW - DNA Primers KW - RNA, Messenger KW - Metallothionein KW - 9038-94-2 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - Rats, Inbred F344 KW - Base Sequence KW - Humans KW - Male KW - Female KW - China KW - Arsenic -- toxicity KW - RNA, Messenger -- blood KW - Metallothionein -- genetics KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70725176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Blood+metallothionein+transcript+as+a+biomarker+for+metal+sensitivity%3A+low+blood+metallothionein+transcripts+in+arsenicosis+patients+from+Guizhou%2C+China.&rft.au=Liu%2C+Jie%3BCheng%2C+Min-Liang%3BYang%2C+Qin%3BShan%2C+Ke-Ren%3BShen%2C+Jun%3BZhou%2C+Yushu%3BZhang%2C+Xinjiang%3BDill%2C+Anna+L%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2007-07-01&rft.volume=115&rft.issue=7&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 1999 Nov 12;58(5):313-27 [10598956] Toxicol Appl Pharmacol. 1985 Mar 30;78(1):63-8 [4035673] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] J Toxicol Environ Health A. 2000 Dec 15;61(7):553-67 [11127411] Toxicol Sci. 2001 Jan;59(1):185-92 [11134558] Br J Nutr. 2000 Nov;84(5):747-56 [11177190] Toxicology. 2001 Jun 21;163(2-3):93-100 [11516518] J Toxicol Environ Health A. 2001 Nov 23;64(6):473-84 [11732698] J Prev Soc Med. 1999 Jun;18(1):35-40 [12179653] Environ Health Perspect. 2002 Feb;110(2):119-22 [11836136] J Biochem. 2002 Aug;132(2):217-21 [12153718] Environ Health Perspect. 2002 Oct;110 Suppl 5:827-30 [12426140] Carcinogenesis. 2003 Jan;24(1):25-9 [12538345] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Int J Cancer. 2003 May 10;104(6):735-44 [12640681] Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421] Pathol Oncol Res. 2004;10(2):74-9 [15188022] Toxicol Sci. 2004 Jul;80(1):69-73 [15071173] Int J Oncol. 2004 Aug;25(2):325-33 [15254729] Yale J Biol Med. 2003;76(2):55-62 [15369632] Cell. 1981 Jul;25(1):233-40 [6168387] Toxicology. 1986 Mar;38(3):261-8 [3952754] Experientia Suppl. 1987;52:519-23 [2959543] Int Arch Occup Environ Health. 1988;60(6):413-7 [3410551] Methods Enzymol. 1991;205:613-26 [1779825] Arch Neurol. 1992 Jul;49(7):721-4 [1497498] Chem Biol Interact. 1992 Dec;85(2-3):127-40 [1493605] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Biochemistry. 1994 Jun 14;33(23):7250-9 [8003488] J Pharmacol Exp Ther. 1996 May;277(2):1026-33 [8627513] Cancer Chemother Pharmacol. 1997;40(4):358-62 [9225956] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 2004 Nov 1;64(21):7766-72 [15520181] Toxicol Lett. 2005 Feb 15;155(2):319-27 [15603927] Toxicol Sci. 2005 Feb;83(2):372-9 [15509664] Environ Health Perspect. 2006 Mar;114(3):404-11 [16507464] Int J Cancer. 2006 Jul 1;119(1):28-32 [16432836] Biomed Environ Sci. 2006 Apr;19(2):104-9 [16827180] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] Toxicol Lett. 2006 Nov 1;167(1):47-53 [17029826] Hum Genet. 2006 Nov;120(4):553-60 [16927099] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):419-33 [10774930] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-air pollution interactions in asthma. AN - 70672060; 17607002 AB - Genetic and environmental factors interact to cause asthma. However, genetic studies have generally ignored environmental factors and environmental studies have generally ignored genetics. Thus, there are few examples from the literature of specific gene-environment interactions in relation to asthma. The clearest examples of genetic interactions for inhaled pollutants exist for endotoxin, environmental tobacco smoke, and ozone. Endotoxin-genetic interactions in asthma are the focus of two other manuscripts from this conference, so this review focuses on environmental tobacco smoke and ozone. In the sparse literature, there is evidence for the role of specific genes involved in oxidative stress, notably GSTM1 and TNF, in the respiratory responses to ozone and environmental tobacco smoke. There are few data on genes involved in innate immune pathways, which are crucial in response to endotoxin and may play a role in response to ozone and environmental tobacco smoke. Genes involved in oxidative stress may interact with both air pollutants and diet in relation to asthma phenotypes. Future directions to advance the field include whole genome association studies, better assessment of exposure and phenotypes, and consideration of joint interactions with diet and other co-factors that influence individual susceptibility. JF - Proceedings of the American Thoracic Society AU - London, Stephanie J AD - Epidemiology Branch and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. London2@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 217 EP - 220 VL - 4 IS - 3 SN - 1546-3222, 1546-3222 KW - Tobacco Smoke Pollution KW - 0 KW - Tumor Necrosis Factor-alpha KW - Ozone KW - 66H7ZZK23N KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Glutathione Transferase KW - glutathione S-transferase M1 KW - Index Medicus KW - Phenotype KW - Glutathione S-Transferase pi -- genetics KW - Genotype KW - Polymorphism, Genetic KW - Humans KW - Glutathione Transferase -- genetics KW - Genetic Predisposition to Disease KW - Tumor Necrosis Factor-alpha -- genetics KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70672060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+American+Thoracic+Society&rft.atitle=Gene-air+pollution+interactions+in+asthma.&rft.au=London%2C+Stephanie+J&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2007-07-01&rft.volume=4&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+American+Thoracic+Society&rft.issn=15463222&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2001 May;163(6):1426-31 [11371413] Am J Respir Crit Care Med. 2006 Dec 15;174(12):1335-41 [17023730] Am J Respir Crit Care Med. 2002 Aug 15;166(4):457-63 [12186820] Toxicol Lett. 2002 Aug 5;134(1-3):219-25 [12191881] Nat Genet. 2003 Feb;33(2):177-82 [12524541] Am J Respir Crit Care Med. 2003 Apr 15;167(8):1083-9 [12522030] J Allergy Clin Immunol. 2003 Apr;111(4):840-6 [12704367] JAMA. 2003 Oct 8;290(14):1859-67 [14532314] JAMA. 2003 Oct 8;290(14):1915-7 [14532321] Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204 [12969868] Thorax. 2004 Jan;59(1):8-10 [14694237] Thorax. 2004 Apr;59(4):295-302 [15047948] Am J Respir Cell Mol Biol. 2004 Jul;31(1):69-77 [14975936] Am J Respir Crit Care Med. 2004 Jul 15;170(2):126-32 [15020293] Am J Respir Crit Care Med. 2004 Aug 1;170(3):279-87 [15117740] Pharmacogenetics. 1991 Nov;1(2):110-3 [1844868] Am J Respir Crit Care Med. 1996 Jan;153(1):3-50 [8542133] Environ Health Perspect. 2007 Apr;115(4):616-22 [17450233] Nat Genet. 1997 Dec;17(4):471-4 [9398853] Nat Genet. 1997 Dec;17(4):475-8 [9398854] Am J Respir Crit Care Med. 1998 Jul;158(1):226-32 [9655734] Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6 [15486341] J Allergy Clin Immunol. 2005 Jun;115(6):1169-75 [15940130] Am J Respir Crit Care Med. 2005 Jul 15;172(2):173-82 [15879416] Thorax. 2005 Dec;60(12):1052-8 [16131525] Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8 [16166621] Am J Respir Crit Care Med. 2006 Feb 1;173(3):264-70 [16239624] Genes Immun. 2006 Mar;7(2):95-100 [16395390] Environ Health Perspect. 2006 Apr;114(4):627-33 [16581557] Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L931-45 [16361358] Am J Respir Crit Care Med. 2006 May 1;173(9):970-6 [16456144] Pediatrics. 2006 Aug;118(2):710-6 [16882827] Lancet. 2006 Aug 26;368(9537):733-43 [16935684] Eur Respir J. 2006 Nov;28(5):953-9 [16870661] Epidemiology. 2001 Sep;12(5):577-83 [11505179] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preeclampsia risk in women exposed in utero to diethylstilbestrol. AN - 70667429; 17601905 AB - To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters. This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia cases (210 exposed and 75 unexposed) occurred in 7,313 live births (4,759 DES exposed and 2,554 unexposed). Poisson regression analysis estimated relative risks and 95% confidence intervals (CI) for preeclampsia adjusted for age at the index pregnancy, parity, education, smoking, body mass index, year of diagnosis, and cohort. In utero DES exposure was associated with nearly a 50% elevation in preeclampsia risk. Adjustment for preeclampsia risk factors attenuated the relative risk slightly (1.42, 95% CI 1.04-1.94). The excess risk with DES was concentrated among women who developed preeclampsia in their first pregnancies (relative risk 1.81, 95% CI 1.17-2.79), who were exposed before 15 weeks of gestation (relative risk 1.57, 95% CI 1.11-2.23), and who were treated with magnesium sulfate (relative risk 2.10, 95% CI 0.82-5.42). Among DES-exposed women who had a prior hysterosalpingogram, preeclampsia prevalence was higher in those with uterine abnormalities (12.4%) than in those without (7.7%). These data suggest that in utero exposure to DES is associated with a slightly elevated risk of preeclampsia, and that one possible biological mechanism involves uterine abnormalities. JF - Obstetrics and gynecology AU - Troisi, Rebecca AU - Titus-Ernstoff, Linda AU - Hyer, Marianne AU - Hatch, Elizabeth E AU - Robboy, Stanley J AU - Strohsnitter, William AU - Palmer, Julie R AU - Øglaend, Bjørn AU - Adam, Ervin AU - Kaufman, Raymond AU - Herbst, Arthur L AU - Hoover, Robert N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. troisir@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 113 EP - 120 VL - 110 IS - 1 SN - 0029-7844, 0029-7844 KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Health Surveys KW - Cohort Studies KW - Adult KW - Uterus -- abnormalities KW - Follow-Up Studies KW - Uterus -- drug effects KW - Female KW - Proportional Hazards Models KW - Pregnancy KW - Diethylstilbestrol -- adverse effects KW - Pre-Eclampsia -- epidemiology KW - Pre-Eclampsia -- chemically induced KW - Estrogens, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70667429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Preeclampsia+risk+in+women+exposed+in+utero+to+diethylstilbestrol.&rft.au=Troisi%2C+Rebecca%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BHatch%2C+Elizabeth+E%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William%3BPalmer%2C+Julie+R%3B%C3%98glaend%2C+Bj%C3%B8rn%3BAdam%2C+Ervin%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-01&rft.volume=110&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70658413; 17335637 AB - There is a lack of current detailed national data on the prevalence, correlates, disability and co-morbidity of DSM-IV specific phobia (SP), the prevalence of specific objects and situations feared, and associations between impairment, treatment and co-morbidity and the number of specific situations and objects feared, among adults in the USA. The data were derived from a large (43093) representative sample of the adult population in the USA. Prevalences of 12-month and lifetime DSM-IV SP were 7.1% and 9.4% respectively. Being female, young, and low income increased risk, while being Asian or Hispanic decreased risk (p<0.05). The mean age at onset of SP was 9.7 years, the mean duration of episode was 20.1 years and only 8.0% reported treatment specifically for SP. Most specific phobias involved multiple fears, and an increasing number of fears, regardless of content, was associated with greater disability and impairment, treatment seeking and co-morbidity with other Axis I and II disorders. SP is a highly prevalent, disabling and co-morbid disorder in the US adult population. The early onset of SP and the disorders most strongly associated with it highlights the need for longitudinal studies beginning in early childhood. Results suggest the existence of a generalized subtype of SP much like social phobia, which, once revealed, may lead to a classification of SP that is more etiologically and therapeutically meaningful. JF - Psychological medicine AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Patricia Chou, S AU - Smith, Sharon AU - Goldstein, Rise B AU - June Ruan, W AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1047 EP - 1059 VL - 37 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Age of Onset KW - Humans KW - Aged KW - Comorbidity KW - Psychiatric Status Rating Scales KW - Adult KW - Health Surveys KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Phobic Disorders -- therapy KW - Phobic Disorders -- epidemiology KW - Phobic Disorders -- diagnosis KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70658413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=The+epidemiology+of+DSM-IV+specific+phobia+in+the+USA%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Stinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BPatricia+Chou%2C+S%3BSmith%2C+Sharon%3BGoldstein%2C+Rise+B%3BJune+Ruan%2C+W%3BGrant%2C+Bridget+F&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=2007-07-01&rft.volume=37&rft.issue=7&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2007-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Decline in lung function and mortality: implications for medical monitoring. AN - 70646571; 17332137 AB - To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEV(1)). Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEV(1) rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. The risk ratios (compared to "below 30 ml/year") were 1.39 (95% CI 0.99 to 1.97) in the "60 to less than 90 ml/year" category and 1.90 (95% CI 1.32 to 2.76) in the "90 ml/year and above" category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with increased mortality. Risk of death increases in individuals with rates of decline above about 60 ml/year and is statistically significant with declines of 90 ml/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals. JF - Occupational and environmental medicine AU - Sircar, Kanta AU - Hnizdo, Eva AU - Petsonk, Edward AU - Attfield, Michael AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. KSircar@cdc.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 461 EP - 466 VL - 64 IS - 7 KW - Index Medicus KW - Humans KW - Adult KW - Disease Progression KW - Middle Aged KW - Follow-Up Studies KW - Monitoring, Physiologic KW - Risk Assessment -- methods KW - Forced Expiratory Volume KW - Male KW - Proportional Hazards Models KW - Occupational Diseases -- physiopathology KW - Lung Diseases -- physiopathology KW - Coal Mining KW - Lung Diseases -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70646571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Decline+in+lung+function+and+mortality%3A+implications+for+medical+monitoring.&rft.au=Sircar%2C+Kanta%3BHnizdo%2C+Eva%3BPetsonk%2C+Edward%3BAttfield%2C+Michael&rft.aulast=Sircar&rft.aufirst=Kanta&rft.date=2007-07-01&rft.volume=64&rft.issue=7&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-09 N1 - Date created - 2007-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Diabet Med. 2000 Feb;17(2):119-23 [10746481] Chest. 2005 Jun;127(6):1952-9 [15947307] Thorax. 2001 Sep;56(9):703-7 [11514691] Thorax. 2003 May;58(5):388-93 [12728157] Occup Environ Med. 2004 Oct;61(10):854-60 [15377772] Arch Environ Health. 1974 Apr;28(4):182-9 [4814954] Am Rev Respir Dis. 1979 May;119(5):831-8 [453705] Thorax. 1982 Mar;37(3):193-7 [6980496] Am J Epidemiol. 1982 Jul;116(1):102-13 [7102646] Br Med J (Clin Res Ed). 1983 Jan 22;286(6361):249-51 [6402057] Thorax. 1985 Feb;40(2):132-7 [3975864] J Chronic Dis. 1985;38(8):703-10 [4019706] Int J Epidemiol. 1986 Mar;15(1):56-64 [3957544] Am Rev Respir Dis. 1986 Jun;133(6):974-80 [3717769] Am J Epidemiol. 1986 Dec;124(6):942-8 [3776976] Stat Med. 1988 Jan-Feb;7(1-2):11-8 [3353600] Am Rev Respir Dis. 1991 Nov;144(5):1202-18 [1952453] Am Rev Respir Dis. 1992 Mar;145(3):605-9 [1546842] Eur Respir J. 1992 Apr;5(4):452-62 [1563504] Am J Public Health. 1992 Jul;82(7):964-70 [1535182] Chest. 1993 Feb;103(2):536-40 [8432150] Br J Ind Med. 1993 Oct;50(10):929-37 [8217853] Am J Public Health. 1994 Jul;84(7):1086-93 [8017530] Am J Epidemiol. 1994 Sep 1;140(5):398-408 [8067332] Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):390-8 [7842197] Am J Ind Med. 1995 Aug;28(2):167-84 [8585515] BMJ. 1996 Sep 21;313(7059):711-5; discussion 715-6 [8819439] Ann Epidemiol. 1996 May;6(3):217-27 [8827157] Chest. 1997 Jun;111(6):1526-32 [9187168] Occup Environ Med. 1997 Oct;54(10):708-13 [9404317] Ann Epidemiol. 1998 Feb;8(2):99-106 [9491934] Am J Epidemiol. 1998 Jun 1;147(11):1011-8 [9620044] Am J Respir Crit Care Med. 1999 Jan;159(1):179-87 [9872837] J Epidemiol Community Health. 1999 Apr;53(4):230-4 [10396549] J Clin Invest. 1958 Jul;37(7):1049-60 [13563634] Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):633-9 [11254516] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling. AN - 70644586; 17482223 AB - Consistent with the U.S. Food and Drug Administration (FDA) Critical Path Initiative, predictive toxicology software programs employing quantitative structure-activity relationship (QSAR) models are currently under evaluation for regulatory risk assessment and scientific decision support for highly sensitive endpoints such as carcinogenicity, mutagenicity and reproductive toxicity. At the FDA's Center for Food Safety and Applied Nutrition's Office of Food Additive Safety and the Center for Drug Evaluation and Research's Informatics and Computational Safety Analysis Staff (ICSAS), the use of computational SAR tools for both qualitative and quantitative risk assessment applications are being developed and evaluated. One tool of current interest is MDL-QSAR predictive discriminant analysis modeling of rodent carcinogenicity, which has been previously evaluated for pharmaceutical applications by the FDA ICSAS. The study described in this paper aims to evaluate the utility of this software to estimate the carcinogenic potential of small, organic, naturally occurring chemicals found in the human diet. In addition, a group of 19 known synthetic dietary constituents that were positive in rodent carcinogenicity studies served as a control group. In the test group of naturally occurring chemicals, 101 were found to be suitable for predictive modeling using this software's discriminant analysis modeling approach. Predictions performed on these compounds were compared to published experimental evidence of each compound's carcinogenic potential. Experimental evidence included relevant toxicological studies such as rodent cancer bioassays, rodent anti-carcinogenicity studies, genotoxic studies, and the presence of chemical structural alerts. Statistical indices of predictive performance were calculated to assess the utility of the predictive modeling method. Results revealed good predictive performance using this software's rodent carcinogenicity module of over 1200 chemicals, comprised primarily of pharmaceutical, industrial and some natural products developed under an FDA-MDL cooperative research and development agreement (CRADA). The predictive performance for this group of dietary natural products and the control group was 97% sensitivity and 80% concordance. Specificity was marginal at 53%. This study finds that the in silico QSAR analysis employing this software's rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity. It is the first study to demonstrate successful QSAR predictive modeling of naturally occurring carcinogens found in the human diet using an external validation test. Further test validation of this software and expansion of the training data set for dietary chemicals will help to support the future use of such QSAR methods for screening and prioritizing the risk of dietary chemicals when actual animal data are inadequate, equivocal, or absent. JF - Toxicology and applied pharmacology AU - Valerio, Luis G AU - Arvidson, Kirk B AU - Chanderbhan, Ronald F AU - Contrera, Joseph F AD - Division of Biotechnology and GRAS Notice Review, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA. luis.valerio@FDA.HHS.gov Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 1 EP - 16 VL - 222 IS - 1 SN - 0041-008X, 0041-008X KW - Biological Products KW - 0 KW - Carcinogens KW - Xenobiotics KW - Index Medicus KW - Rats KW - Software KW - Animals KW - Humans KW - Databases, Factual KW - Models, Statistical KW - Mice KW - Forecasting KW - Models, Biological KW - Risk Assessment KW - Quantitative Structure-Activity Relationship KW - Carcinogens -- toxicity KW - Xenobiotics -- toxicity KW - Diet KW - Biological Products -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70644586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Prediction+of+rodent+carcinogenic+potential+of+naturally+occurring+chemicals+in+the+human+diet+using+high-throughput+QSAR+predictive+modeling.&rft.au=Valerio%2C+Luis+G%3BArvidson%2C+Kirk+B%3BChanderbhan%2C+Ronald+F%3BContrera%2C+Joseph+F&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2007-07-01&rft.volume=222&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies. AN - 70627209; 17431034 AB - CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. The impact of CYP1A induction on the carcinogenic and toxic potentials of environmental, occupational, dietary, and therapeutic chemicals has been a central focus of human risk evaluation and has broadly influenced the fields of cancer research, toxicology, pharmacology, and risk assessment over the past half-century. From the early discovery of CYP1A induction and its role in protection against chemical carcinogenesis in intact animals, to the establishment of CYP1A enzymes as the principal cytochromes P450 for bioactivation of PAHs and HAAs in in vitro assays, to the recent realization of an essential protective role of CYP1A in benzo[a]pyrene-induced lethality and carcinogenesis with CYP1A knockout mice, the understanding of the interrelation between CYP1A induction and chemical safety has followed a full circle. This unique path of CYP1A research underscores the importance of whole animal and human studies in chemical safety evaluation. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Ma, Qiang AU - Lu, Anthony Y H AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. qam1@cdc.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1009 EP - 1016 VL - 35 IS - 7 SN - 0090-9556, 0090-9556 KW - Amines KW - 0 KW - Anti-Ulcer Agents KW - Carcinogens KW - Heterocyclic Compounds KW - Polycyclic Aromatic Hydrocarbons KW - Receptors, Aryl Hydrocarbon KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Receptors, Aryl Hydrocarbon -- drug effects KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Animals KW - Drug Interactions KW - Anti-Ulcer Agents -- adverse effects KW - Omeprazole -- adverse effects KW - Humans KW - Mice KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Risk Assessment KW - Mice, Knockout KW - Enzyme Induction -- drug effects KW - Biotransformation KW - Amines -- toxicity KW - Benzo(a)pyrene -- toxicity KW - Toxicity Tests -- methods KW - Heterocyclic Compounds -- toxicity KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Cytochrome P-450 CYP1A1 -- genetics KW - Neoplasms -- enzymology KW - Carcinogens -- metabolism KW - Cytochrome P-450 CYP1A2 -- genetics KW - Cell Transformation, Neoplastic -- metabolism KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Cell Transformation, Neoplastic -- drug effects KW - Cytochrome P-450 CYP1A2 -- biosynthesis KW - Neoplasms -- genetics KW - Cytochrome P-450 CYP1A1 -- biosynthesis KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70627209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=CYP1A+induction+and+human+risk+assessment%3A+an+evolving+tale+of+in+vitro+and+in+vivo+studies.&rft.au=Ma%2C+Qiang%3BLu%2C+Anthony+Y+H&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2007-07-01&rft.volume=35&rft.issue=7&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking cigarettes before first childbirth and risk of breast cancer. AN - 70621877; 17426039 AB - Inconsistent epidemiologic findings on cigarette smoking and female breast cancer risk may reflect insufficient assessment of smoking onset and amount relative to reproductive events. To determine the risk of breast cancer associated with smoking during different periods of reproductive life, the authors evaluated 906 incident breast cancer cases in a nationwide cohort of 56,042 female US radiologic technologists (1983-1998) who responded to two questionnaire surveys. After they accounted for age, birth cohort, and established breast cancer risk factors, smoking-related breast cancer risks differed by smoking during three reproductive time periods (p = 0.003), with a statistically significant 3% increase per pack-year of smoking between menarche and first childbirth (relative risk = 1.03, 95% confidence interval: 1.02, 1.05) and no significant association for smoking after first childbirth. Risk also increased with younger age at smoking initiation (p-trend = 0.06), after adjustment for pack-years of smoking before and after first childbirth, indicating an independent effect of age at smoking initiation. The findings from this study suggest that sensitivity of the female breast to tobacco carcinogens is increased during adolescence and early adulthood but decreases after first childbirth, when most breast tissue has terminally differentiated. JF - American journal of epidemiology AU - Ha, Mina AU - Mabuchi, Kiyohiko AU - Sigurdson, Alice J AU - Freedman, D Michal AU - Linet, Martha S AU - Doody, Michele Morin AU - Hauptmann, Michael AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. minaha@dankook.ac.kr Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 55 EP - 61 VL - 166 IS - 1 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Parity KW - Humans KW - Premenopause KW - Aged KW - Pregnancy KW - Postmenopause KW - Risk Factors KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Breast Neoplasms -- etiology KW - Smoking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70621877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Smoking+cigarettes+before+first+childbirth+and+risk+of+breast+cancer.&rft.au=Ha%2C+Mina%3BMabuchi%2C+Kiyohiko%3BSigurdson%2C+Alice+J%3BFreedman%2C+D+Michal%3BLinet%2C+Martha+S%3BDoody%2C+Michele+Morin%3BHauptmann%2C+Michael&rft.aulast=Ha&rft.aufirst=Mina&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-02 N1 - Date created - 2007-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey. AN - 70603817; 17084837 AB - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31.1 microg/dl. The estimated geometric mean was 2.2 microg/dl, and the estimated arithmetic mean was 2.8 microg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1.7 microg/dl for follicle stimulating hormone and 2.8 microg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries. JF - Environmental research AU - Krieg, Edward F AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, MS C-22, Cincinnati, OH 45226, USA. erk3@cdc.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 374 EP - 382 VL - 104 IS - 3 SN - 0013-9351, 0013-9351 KW - Follicle Stimulating Hormone, Human KW - 0 KW - Lead KW - 2P299V784P KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - United States KW - Regression Analysis KW - Humans KW - Premenopause KW - Aged KW - Nutrition Surveys KW - Multivariate Analysis KW - Postmenopause KW - Adult KW - Surveys and Questionnaires KW - Bone Density KW - Middle Aged KW - Ovariectomy KW - Female KW - Environmental Monitoring KW - Health Surveys KW - Luteinizing Hormone -- blood KW - Lead -- blood KW - Follicle Stimulating Hormone, Human -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70603817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Acute+oral+toxicity+of+colchicine+in+rats%3A+effects+of+gender%2C+vehicle+matrix+and+pre-exposure+to+lipopolysaccharide.&rft.au=Wiesenfeld%2C+Paddy+L%3BGarthoff%2C+Larry+H%3BSobotka%2C+Thomas+J%3BSuagee%2C+Jessica+K%3BBarton%2C+Curtis+N&rft.aulast=Wiesenfeld&rft.aufirst=Paddy&rft.date=2007-09-01&rft.volume=27&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-03 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. AN - 70569688; 17182183 AB - Although lumbar radicular pain is the most common chronic neuropathic pain syndrome, there have been few randomized studies of drug treatments. We compared the efficacy of morphine (15-90 mg), nortriptyline (25-100 mg), their combination, and a benztropine "active placebo" (0.25-1 mg) in patients with chronic sciatica. Each period consisted of 5 weeks of dose escalation, 2 weeks of maintenance at the highest tolerated doses, and 2 weeks of dose tapering. The primary outcome was the mean daily leg pain score on a 0-10 scale during the maintenance period. Secondary outcomes included a 6-point ordinal global pain relief scale, the Beck Depression Inventory (BDI), the Oswestry Back Pain Disability Index (ODI) and the SF-36. In the 28 out of 61 patients who completed the study, none of the treatments produced significant reductions in average leg pain or other leg or back pain scores. Pain reduction, relative to placebo treatment was, 14% for nortriptyline (95% CI=[-2%, 30%]), 7% for morphine (95% CI=[-8%, 22%]), and 7% for the combination treatment (95% CI=[-4%, 18%]). Mean doses were: nortriptyline alone, 84+/-24.44 (SD) mg/day; morphine alone, 62+/-29 mg/day; and combination, morphine, 49+/-27 mg/day plus nortriptyline, 55 mg+/-33.18 mg/day. Over half of the study completers reported some adverse effect with morphine, nortriptyline or their combination. Within the limitations of the modest sample size and high dropout rate, these results suggest that nortriptyline, morphine and their combination may have limited effectiveness in the treatment of chronic sciatica. JF - Pain AU - Khoromi, Suzan AU - Cui, Lihong AU - Nackers, Lisa AU - Max, Mitchell B AD - Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. khoromisu@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 66 EP - 75 VL - 130 IS - 1-2 KW - Analgesics, Opioid KW - 0 KW - Antidepressive Agents, Tricyclic KW - Placebos KW - Morphine KW - 76I7G6D29C KW - Nortriptyline KW - BL03SY4LXB KW - Index Medicus KW - Spinal Nerve Roots KW - Humans KW - Aged KW - Drug Therapy, Combination KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Chronic Disease KW - Middle Aged KW - Female KW - Male KW - Lumbar Vertebrae KW - Antidepressive Agents, Tricyclic -- administration & dosage KW - Sciatica -- drug therapy KW - Morphine -- adverse effects KW - Nortriptyline -- adverse effects KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Morphine -- administration & dosage KW - Nortriptyline -- administration & dosage KW - Radiculopathy -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70569688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Morphine%2C+nortriptyline+and+their+combination+vs.+placebo+in+patients+with+chronic+lumbar+root+pain.&rft.au=Khoromi%2C+Suzan%3BCui%2C+Lihong%3BNackers%2C+Lisa%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2007-07-01&rft.volume=130&rft.issue=1-2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=1872-6623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Med Res Opin. 2006 Feb;22(2):375-84 [16466610] Pain. 2005 Dec 5;118(3):289-305 [16213659] J Rheumatol. 2000 Mar;27(3):772-8 [10743823] Spine (Phila Pa 1976). 2000 Dec 15;25(24):3130-9 [11124729] Spine (Phila Pa 1976). 2001 Mar 1;26(5):E93-E113 [11242399] Pain. 2001 Nov;94(2):149-58 [11690728] Anesthesiology. 2002 May;96(5):1053-61 [11981142] Neurology. 2002 Oct 8;59(7):1015-21 [12370455] Neurology. 2003 Mar 25;60(6):927-34 [12654955] N Engl J Med. 2003 Mar 27;348(13):1223-32 [12660386] Neurology. 2003 Apr 22;60(8):1274-83 [12707429] Neurology. 2003 Apr 22;60(8):1284-9 [12707430] Pain. 2003 Sep;105(1-2):71-8 [14499422] Arch Neurol. 2003 Nov;60(11):1524-34 [14623723] Am J Med. 2004 Sep 6;117 Suppl 5A:2S-7S [15478846] Br J Clin Pharmacol. 1979 Jul;8(1):7-20 [552299] Physiotherapy. 1980 Aug;66(8):271-3 [6450426] Neurology. 1982 Jun;32(6):671-3 [6283422] Pain. 1986 Oct;27(1):117-26 [3785962] J Chronic Dis. 1987;40(3):251-8 [3818881] Pain. 1988 Apr;33(1):11-23 [2454440] Neurology. 1988 Sep;38(9):1427-32 [3412591] Arthritis Rheum. 1990 Feb;33(2):160-72 [2306288] Clin Pharmacol Ther. 1990 Mar;47(3):305-12 [2178851] Neurology. 1991 Jul;41(7):1024-8 [1712433] N Engl J Med. 1992 May 7;326(19):1250-6 [1560801] Pain. 1993 Nov;55(2):259-66 [8309713] Lancet. 1996 Jan 20;347(8995):143-7 [8544547] Lancet. 1997 Mar 15;349(9054):753-8 [9074573] Neurology. 1998 Jun;50(6):1837-41 [9633737] Psychosomatics. 1998 May-Jun;39(3):263-72 [9664773] Pain. 1998 Jun;76(3):287-96 [9718247] Neurology. 1998 Oct;51(4):1166-71 [9781549] Pain. 1999 Dec;83(3):389-400 [10568846] J Pain Symptom Manage. 1998 Oct;16(4):220-9 [9803049] Neurology. 2004 Dec 14;63(11):2104-10 [15596757] N Engl J Med. 2005 Mar 31;352(13):1324-34 [15800228] J Pain. 2005 Apr;6(4):253-60 [15820913] JAMA. 2005 Jun 22;293(24):3043-52 [15972567] Expert Rev Neurother. 2005 Nov;5(6):823-30 [16274339] J Pain. 2005 Dec;6(12):829-36 [16326371] Anesthesiology. 2006 Jun;104(6):1283-92 [16732101] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ATSDR evaluation of potential for human exposure to zinc. AN - 70121662; 18386523 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for zinc. The primary purpose of this article is to provide interested individuals with environmental information on zinc that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories. JF - Toxicology and industrial health AU - Roney, Nickolette AU - Osier, Mark AU - Paikoff, Sari J AU - Smith, Cassandra V AU - Williams, Malcolm AU - De Rosa, Christopher T AU - Agency for Toxic Substances and Disease Registry AD - Agency for Toxic Substances and Disease Registry, DTEM, U.S. Department of Health and Human Services, 1600 Clifton Road, Mailstop F32, Atlanta, GA 30333, USA. nroney@cdc.gov ; Agency for Toxic Substances and Disease Registry PY - 2007 SP - 247 EP - 308 VL - 23 IS - 5-6 SN - 0748-2337, 0748-2337 KW - Environmental Pollutants KW - 0 KW - Hazardous Waste KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - United States KW - Registries KW - Hazardous Waste -- legislation & jurisprudence KW - Humans KW - United States Dept. of Health and Human Services KW - Environmental Pollutants -- analysis KW - Environmental Monitoring KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70121662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+potential+for+human+exposure+to+zinc.&rft.au=Roney%2C+Nickolette%3BOsier%2C+Mark%3BPaikoff%2C+Sari+J%3BSmith%2C+Cassandra+V%3BWilliams%2C+Malcolm%3BDe+Rosa%2C+Christopher+T%3BAgency+for+Toxic+Substances+and+Disease+Registry&rft.aulast=Roney&rft.aufirst=Nickolette&rft.date=2007-07-01&rft.volume=23&rft.issue=5-6&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - ATSDR evaluation of potential for human exposure to tungsten. AN - 70121562; 18386524 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act, National Priorities List sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Tungsten. The primary purpose of this article is to provide interested individuals with environmental information on tungsten that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories. JF - Toxicology and industrial health AU - Keith, L Samuel AU - Wohlers, David W AU - Moffett, Daphne B AU - Rosemond, Zemoria A AU - Agency for Toxic Substances and Disease Registry AD - Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. skeith@cdc.gov ; Agency for Toxic Substances and Disease Registry PY - 2007 SP - 309 EP - 345 VL - 23 IS - 5-6 SN - 0748-2337, 0748-2337 KW - Environmental Pollutants KW - 0 KW - Hazardous Waste KW - Tungsten KW - V9306CXO6G KW - Index Medicus KW - United States KW - Registries KW - Hazardous Waste -- legislation & jurisprudence KW - Humans KW - United States Dept. of Health and Human Services KW - Environmental Pollutants -- analysis KW - Environmental Monitoring KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70121562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+potential+for+human+exposure+to+tungsten.&rft.au=Keith%2C+L+Samuel%3BWohlers%2C+David+W%3BMoffett%2C+Daphne+B%3BRosemond%2C+Zemoria+A%3BAgency+for+Toxic+Substances+and+Disease+Registry&rft.aulast=Keith&rft.aufirst=L&rft.date=2007-07-01&rft.volume=23&rft.issue=5-6&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Use of multitoxin immunoaffinity columns for determination of aflatoxins and ochratoxin A in ginseng and ginger. AN - 68217539; 17760342 AB - Conditions were optimized for the simultaneous, alkaline, aqueous methanol extraction of aflatoxins (AFL), i.e., B1 (AFB1), B2 (AFB2), G1 (AFG1), and G2 (AFG2), and ochratoxin A (OTA) with subsequent purification, isolation, and determination of the toxins in ginseng and ginger. Powdered roots were extracted with methanol-0.5% NaHCO3 solution (7 + 3). After shaking and centrifugation, the supernatant was diluted with 100 mM phosphate buffer containing 1% Tween 20 and filtered through glass microfiber filter paper. The filtrate was then passed through an immunoaffinity column, and the toxins were eluted with methanol. The AFL were separated and determined by reversed-phase liquid chromatography (RPLC) with fluorescence detection after postcolumn UV photochemical derivatization. OTA was separated and determined by RPLC with fluorescence detection. Recoveries of AFL added at 2-16 ng/g and OTA added at 1-8 ng/g to ginseng were 72-80 and 86-95%, respectively. Recoveries of AFL and OTA added to ginger were similar to those for ginseng. A total of 39 commercially available ginger products from 6 manufacturers were analyzed. Twenty-six samples were found to be contaminated with AFL at 1-31 ng/g and 29 samples, with OTA at 1-10 ng/g. Ten samples contained no AFL or OTA. Ten ginseng finished products were also analyzed; 3 contained AFL at 0.1 ng/g and 4 contained OTA at levels ranging from 0.4 to 1.8 ng/g. LC/tandem mass spectrometry with multiple-reaction monitoring of 3 collisionally induced product ions from the protonated molecular ions of OTA, AFB1, and AFG1 was used to confirm the identities of the toxins in extracts of the finished products. JF - Journal of AOAC International AU - Trucksess, Mary W AU - Weaver, Carol M AU - Oles, Carolyn J AU - Rump, Lydia V AU - White, Kevin D AU - Betz, Joseph M AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov PY - 2007 SP - 1042 EP - 1049 VL - 90 IS - 4 SN - 1060-3271, 1060-3271 KW - Aflatoxins KW - 0 KW - Ochratoxins KW - Plant Extracts KW - Solvents KW - ochratoxin A KW - 1779SX6LUY KW - Index Medicus KW - Mass Spectrometry KW - Centrifugation KW - Chromatography, Liquid -- methods KW - Plant Extracts -- metabolism KW - Panax -- metabolism KW - Spectrophotometry, Ultraviolet -- methods KW - Food Contamination KW - Plant Roots -- metabolism KW - Ochratoxins -- analysis KW - Food Analysis -- methods KW - Aflatoxins -- analysis KW - Ginger -- metabolism KW - Immunoassay -- methods KW - Chromatography, Ion Exchange -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68217539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Use+of+multitoxin+immunoaffinity+columns+for+determination+of+aflatoxins+and+ochratoxin+A+in+ginseng+and+ginger.&rft.au=Trucksess%2C+Mary+W%3BWeaver%2C+Carol+M%3BOles%2C+Carolyn+J%3BRump%2C+Lydia+V%3BWhite%2C+Kevin+D%3BBetz%2C+Joseph+M%3BRader%2C+Jeanne+I&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2007-07-01&rft.volume=90&rft.issue=4&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-29 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Food and Drug Administration Office of Women's Health: impact of science on regulatory policy. AN - 68128542; 17678451 AB - In 1994, the Food and Drug Administration Office of Women's Health (FDA-OWH) was created to provide leadership and policy direction for the Agency regarding issues of women's health. Within its first year, the FDA-OWH established a science program for women's health research, promoting the development of sound policy and regulation. In a little over a decade, the program has provided approximately 14 million dollars to fund more than 100 women's health research studies covering a broad range of health topics affecting women across their lifespan. Some studies, such as those elucidating drug effects on QT prolongation in women and drug-dietary supplement interaction, have had significant influence on regulatory decisions. Other studies have provided sound scientific data on sex and gender differences supporting FDA guidelines to protect women's health. This paper describes the science program at the FDA-OWH, providing examples of how funded research impacts regulatory policy. JF - Journal of women's health (2002) AU - Obias-Manno, Dulce AU - Scott, Pamela E AU - Kaczmarczyk, Joseph AU - Miller, Margaret AU - Pinnow, Ellen AU - Lee-Bishop, Lynda AU - Jones-London, Michelle AU - Chapman, Kennerly AU - Kallgren, Deborah AU - Uhl, Kathleen AD - Food and Drug Administration, FDA/OC/Office of Women's Health, Rockville, Maryland 20857, USA. PY - 2007 SP - 807 EP - 817 VL - 16 IS - 6 SN - 1540-9996, 1540-9996 KW - Index Medicus KW - United States KW - Policy Making KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Humans KW - Budgets KW - Leadership KW - Female KW - Women's Health KW - Research -- legislation & jurisprudence KW - United States Food and Drug Administration -- economics KW - Research -- economics KW - Health Policy -- legislation & jurisprudence KW - United States Food and Drug Administration -- organization & administration KW - Health Policy -- trends KW - Health Policy -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68128542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=The+Food+and+Drug+Administration+Office+of+Women%27s+Health%3A+impact+of+science+on+regulatory+policy.&rft.au=Obias-Manno%2C+Dulce%3BScott%2C+Pamela+E%3BKaczmarczyk%2C+Joseph%3BMiller%2C+Margaret%3BPinnow%2C+Ellen%3BLee-Bishop%2C+Lynda%3BJones-London%2C+Michelle%3BChapman%2C+Kennerly%3BKallgren%2C+Deborah%3BUhl%2C+Kathleen&rft.aulast=Obias-Manno&rft.aufirst=Dulce&rft.date=2007-07-01&rft.volume=16&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=15409996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Womens Health (Larchmt). 2007 Jul-Aug;16(6):818-21 [17678452] N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Explosion Pressure Design Criteria for New Seals in U.S. Coal Mines AN - 58755850; 2007-23621 AB - Seals are used in underground coal mines throughout the United States to isolate abandoned mining areas from the active workings. Prior to the Sago Mine disaster in 2006, mining regulations required seals to withstand a 140-kPa (20-psig) explosion pressure (30 CFR4 75.335). However, Program Information Bulletin No. P06-16 issued by MSHA on July 19, 2006, requires seals to withstand a 345-kPa (50-psig) explosion pressure. The recently enacted MINER Act requires MSHA to increase this design standard by the end of 2007. This report provides a sound scientific and engineering justification to recommend a three-tiered explosion pressure design criterion for new seals in coal mines in response to the MINER Act. The recommendations contained herein apply to new seal design and construction in U.S. coal mines. Tables, Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), July 2007, 84 pp. AU - Brune, Jurgen AU - Sapko, Michael AU - Zipf, Karl Y1 - 2007/07// PY - 2007 DA - July 2007 EP - 84p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Energy resources and policy - Coal and synthetic gas industry KW - Environment and environmental policy - Mining and mineral resources KW - Social conditions and policy - Public safety and security KW - Mining industry - Accidents - Prevention KW - Coal industry - Safety measures KW - Explosions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brune%2C+Jurgen%3BSapko%2C+Michael%3BZipf%2C+Karl&rft.aulast=Brune&rft.aufirst=Jurgen&rft.date=2007-07-01&rft.volume=&rft.issue=&rft.spage=84p&rft.isbn=&rft.btitle=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.title=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2007-144.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Mental Health Benefits in Employer-sponsored Health Plans, 1997--2003 AN - 57305639; 200917160 AB - Data drawn from the Mercer National Survey of Employer-sponsored Health Plans in 1997 and 2003 indicate that a large majority of employers continue to provide some level of coverage for mental health (MH) services in their primary plans. However, a majority of plans continue to impose different benefit limitations for MH than for other medical treatment. Among plans with limitations on MH coverage, there was a sharp increase in the use of limits on inpatient days and outpatient visits between 1997 and 2003. The proportion of employers providing coverage for some MH services decreased; e.g., among small employers, 88% provided coverage for inpatient MH care in 2003, compared with 94% in 1997. These results suggest that parity legislation has had a noticeable but limited effect, but that, at least in the short-term, it is unlikely that universal parity in employer-based plans will be achieved through a legislative strategy. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Teich, Judith L AU - Buck, Jeffrey A AD - Office of Organization and Financing, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 6-1065, Rockville, MD 20857, USA judith.teich@samhsa.hhs.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 343 EP - 348 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 34 IS - 3 SN - 1094-3412, 1094-3412 KW - Coverage KW - Mental health services KW - Corporate health insurance KW - Health insurance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57305639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Mental+Health+Benefits+in+Employer-sponsored+Health+Plans%2C+1997--2003&rft.au=Teich%2C+Judith+L%3BBuck%2C+Jeffrey+A&rft.aulast=Teich&rft.aufirst=Judith&rft.date=2007-07-01&rft.volume=34&rft.issue=3&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-006-9050-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Coverage; Health insurance; Corporate health insurance; Mental health services DO - http://dx.doi.org/10.1007/s11414-006-9050-2 ER - TY - JOUR T1 - Developmental regression and autism reported to the Vaccine Adverse Event Reporting System AN - 57232591; 200805499 AB - We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression. [Reprinted by permission; copyright 2007 Sage Publications Ltd. and The National Autistic Society.] JF - Autism AU - Woo, Emily Jane AU - Ball, Robert AU - Landa, Rebecca AU - Zimmerman, Andrew W AU - Braun, M Miles AD - Center for Biologics Evaluation, Research, Food and Drug Administration, Maryland, USA jane.woo@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 301 EP - 310 PB - Sage Publications, London UK VL - 11 IS - 4 SN - 1362-3613, 1362-3613 KW - Critical incidents KW - Developmental delays KW - Reporting KW - Autism KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=Developmental+regression+and+autism+reported+to+the+Vaccine+Adverse+Event+Reporting+System&rft.au=Woo%2C+Emily+Jane%3BBall%2C+Robert%3BLanda%2C+Rebecca%3BZimmerman%2C+Andrew+W%3BBraun%2C+M+Miles&rft.aulast=Woo&rft.aufirst=Emily&rft.date=2007-07-01&rft.volume=11&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361307078126 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Reporting; Immunization; Autism; Developmental delays; Critical incidents DO - http://dx.doi.org/10.1177/1362361307078126 ER - TY - JOUR T1 - A re-examination of distance as a proxy for severity of illness and the implications for differences in utilization by race/ethnicity AN - 57137450; 200801484 AB - The study analyzes the hospitalization patterns of elderly residents to examine whether the relation between distant travel and severity of illness is uniform across racial/ethnic subgroups. A hypothesis is made that severity thresholds could be higher for minorities than whites. Hospital discharge data from the Healthcare Cost and Utilization Project (HCUP-SID) of the Agency for Health Care Research and Quality for New York residents is used, with a link to the Area Resource File and American Hospital Association's survey files. Logistic models compare the association of distant admission with severity corresponding to each local threshold level, race, and type of hospital admission. The study uses four discrete distance thresholds in contrast to recent work. Also, an examination of severity thresholds for distant travel for different types of admission may clarify different sources of disparities in health care utilization. The findings indicate that minorities are likely to have higher severity thresholds than whites in seeking distant hospital care, although these conclusions depend on the type of condition. The study results imply that if costly elective services were regionalized to get the advantages of high volume for both cost and quality of care, some extra effort at outreach may be desirable to reduce disparities in appropriate care. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Health Economics AU - Basu, Jayasree AU - Friedman, Bernard AD - Agency for Healthcare Research and Quality, Rockville, USA Jbasu@ahrq.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 687 EP - 701 PB - John Wiley, Chichester UK VL - 16 IS - 7 SN - 1057-9230, 1057-9230 KW - Travel KW - Health costs KW - Quality of care KW - Health care KW - Hospitalization KW - Ethnicity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57137450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=A+re-examination+of+distance+as+a+proxy+for+severity+of+illness+and+the+implications+for+differences+in+utilization+by+race%2Fethnicity&rft.au=Basu%2C+Jayasree%3BFriedman%2C+Bernard&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-07-01&rft.volume=16&rft.issue=7&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1192 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Hospitalization; Health care; Quality of care; Ethnicity; Health costs; Travel DO - http://dx.doi.org/10.1002/hec.1192 ER - TY - JOUR T1 - Reservoir simulation-based modeling for characterizing longwall methane emissions and gob gas venthole production AN - 50257419; 2007-098286 AB - Longwall mining alters the fluid-flow-related reservoir properties of the rocks overlying and underlying an extracted panel due to fracturing and relaxation of the strata. These mining-related disturbances create new pressure depletion zones and new flow paths for gas migration and may cause unexpected or uncontrolled migration of gas into the underground workplace. One common technique to control methane emissions in longwall mines is to drill vertical gob gas ventholes into each longwall panel to capture the methane within the overlying fractured strata before it enters the work environment. Thus, it is important to optimize the well parameters, e.g., the borehole diameter, and the length and position of the slotted casing interval relative to the fractured gas-bearing zones. This paper presents the development and results of a comprehensive, "dynamic," three-dimensional reservoir model of a typical multi-panel Pittsburgh coalbed longwall mine. The alteration of permeability fields in and above the panels as a result of the mining-induced disturbances has been estimated from mechanical modeling of the overlying rock mass. Model calibration was performed through history matching the gas production from gob gas ventholes in the study area. Results presented in this paper include a simulation of gas flow patterns from the gas-bearing zones in the overlying strata to the mine environment, as well as the influence of completion practices on optimizing gas production from gob gas ventholes. JF - International Journal of Coal Geology AU - Karacan, C O AU - Esterhuizen, G S AU - Schatzel, S J AU - Diamond, W P Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 225 EP - 245 PB - Elsevier, Amsterdam VL - 71 IS - 2-3 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - Pittsburgh Coal KW - geologic hazards KW - underground mining KW - Pennsylvanian KW - natural gas KW - data processing KW - petroleum KW - rock mechanics KW - reservoir rocks KW - ventilation KW - digital simulation KW - numerical models KW - Paleozoic KW - Carboniferous KW - relaxation KW - gases KW - Allegheny County Pennsylvania KW - safety KW - longwall mining KW - coalbed methane KW - Pennsylvania KW - Pittsburgh Pennsylvania KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50257419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Reservoir+simulation-based+modeling+for+characterizing+longwall+methane+emissions+and+gob+gas+venthole+production&rft.au=Karacan%2C+C+O%3BEsterhuizen%2C+G+S%3BSchatzel%2C+S+J%3BDiamond%2C+W+P&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-07-01&rft.volume=71&rft.issue=2-3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2006.08.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2007-01-01 N1 - Number of references - 33 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Allegheny County Pennsylvania; Carboniferous; coalbed methane; data processing; digital simulation; gases; geologic hazards; longwall mining; mining; natural gas; numerical models; Paleozoic; Pennsylvania; Pennsylvanian; petroleum; Pittsburgh Coal; Pittsburgh Pennsylvania; relaxation; reservoir rocks; rock mechanics; safety; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2006.08.003 ER - TY - JOUR T1 - Incorporation of an Internal Ribosome Entry Site-Dependent Mechanism in Arsenic-Induced GADD45 alpha Expression AN - 20753839; 7529303 AB - We have previously shown that trivalent arsenic (arsenite, As super(3+)) is able to induce GADD45 alpha expression in human bronchial epithelial cells through activation of c-Jun NH sub(2)-terminal kinase and nucleolin-dependent mRNA stabilization. In the present report, we show that As super(3+) is capable of inducing translation of the GADD45 alpha protein through a cap-independent, or rather, an internal ribosome entry site (IRES)-dependent mechanism. In growth-arrested cells, As super(3+) elevated the GADD45 alpha protein level in a dose- and time-dependent manner which did not correlate with the GADD45 alpha mRNA expression. Pretreatment of the cells with rapamycin, an inhibitor for the cap-dependent translation machinery through the suppression of mTOR and p70S6 kinase, failed to affect the induction of the GADD45 alpha protein induced by As super(3+). Sequence analysis revealed a potential IRES element in the 5'-untranslated region of the GADD45 alpha mRNA. This IRES element in the 5'-untranslated region of the GADD45 alpha mRNA is functional in mediating As super(3+)-induced translation of the GADD45 alpha protein in a dicistronic reporter gene activity assay. Immunoprecipitation and proteomic studies suggest that As super(3+) impairs the assembly of the cap-dependent initiating complex for general protein translation but increases the association of human elongation factor 2 and human heterogeneous nuclear ribonucleoprotin with this complex. Thus, these results suggest that in growth-arrested cells, As super(3+) is still capable of inducing GADD45 alpha expression through an IRES-dependent translational regulation. [Cancer Res 2007; 67(13):6146-54] JF - Cancer Research AU - Chang, Qingshan AU - Bhatia, Deepak AU - Zhang, Yadong AU - Meighan, Terry AU - Castranova, Vince AU - Shi, Xianglin AU - Chen, Fei AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 6146 EP - 6154 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 13 SN - 0008-5472, 0008-5472 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Epithelial cells KW - Translation KW - Gadd45A protein KW - Arsenic KW - c-Jun amino-terminal kinase KW - Immunoprecipitation KW - Arsenite KW - Ribosomes KW - Cancer KW - Gene expression KW - Elongation KW - Reporter gene KW - Ribosomal protein S6 kinase KW - Internal ribosome entry site KW - proteomics KW - 5' Untranslated Regions KW - Rapamycin KW - X 24360:Metals KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Incorporation+of+an+Internal+Ribosome+Entry+Site-Dependent+Mechanism+in+Arsenic-Induced+GADD45+alpha+Expression&rft.au=Chang%2C+Qingshan%3BBhatia%2C+Deepak%3BZhang%2C+Yadong%3BMeighan%2C+Terry%3BCastranova%2C+Vince%3BShi%2C+Xianglin%3BChen%2C+Fei&rft.aulast=Chang&rft.aufirst=Qingshan&rft.date=2007-07-01&rft.volume=67&rft.issue=13&rft.spage=6146&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gadd45A protein; Translation; Epithelial cells; Arsenic; c-Jun amino-terminal kinase; Arsenite; Immunoprecipitation; Ribosomes; Cancer; Gene expression; Elongation; Reporter gene; Ribosomal protein S6 kinase; Internal ribosome entry site; proteomics; 5' Untranslated Regions; Rapamycin ER - TY - JOUR T1 - Body Mass and Colorectal Cancer Risk in the NIH-AARP Cohort AN - 20729798; 7460162 AB - In most studies, body mass index (BMI) has been associated with increased risk of colorectal or colon cancer in men, but the relation is weaker and less consistent for women, possibly because of interactions with age or hormone replacement therapy. The authors examined the relation between BMI and colorectal cancer incidence in a large, prospective US cohort of 307,708 men and 209,436 women from the NIH-AARP Diet and Health Study. During follow-up of the cohort from 1995 to 2000, 2,314 cases of colorectal cancer were observed in men and 1,029 in women. BMI was related to increased risk of incident colon cancer, but not rectal cancer, for both men and women. For men, relative risks of colon cancer for a BMI of 18.5-<23, 23-<25, 25-<27.5, 27.5-<30, 30-<32.5, 32.5-<35, 35-<40, and greater than or equal to 40 kg/m super(2) were 1.0 (referent), 1.11, 1.22, 1.44, 1.53, 1.57, 1.71, and 2.39, respectively (95% confidence interval: 1.59, 3.58; p-trend < 0.0005). Corresponding relative risks for women were 1.0, 1.20, 1.29, 1.31, 1.28, 1.13, 1.46, and 1.49 (95% confidence interval: 0.98, 2.25; p-trend = 0.02). BMI was related to colon cancer risk for younger (aged 50-66 years) but not older (aged 67-71 years) women. The association was not modified by hormone replacement therapy in women or physical activity in men or women. JF - American Journal of Epidemiology AU - Adams, Kenneth F AU - Leitzmann, Michael F AU - Albanes, Demetrius AU - Kipnis, Victor AU - Mouw, Traci AU - Hollenbeck, Al AU - Schatzkin, Arthur AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 36 EP - 45 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - Age KW - colorectal carcinoma KW - body mass KW - physical activity KW - Cancer KW - hormone replacement therapy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Body+Mass+and+Colorectal+Cancer+Risk+in+the+NIH-AARP+Cohort&rft.au=Adams%2C+Kenneth+F%3BLeitzmann%2C+Michael+F%3BAlbanes%2C+Demetrius%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BHollenbeck%2C+Al%3BSchatzkin%2C+Arthur&rft.aulast=Adams&rft.aufirst=Kenneth&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Age; body mass; colorectal carcinoma; physical activity; hormone replacement therapy; Cancer ER - TY - JOUR T1 - Cancer risk in women prenatally exposed to diethylstilbestrol AN - 20649261; 8079485 AB - Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in the DES Combined Cohort Follow-up Study using age- and calendar-year specific standardized incidence rate ratios (SIR), and age-adjusted incidence rate ratios (RR) comparing DES exposed and unexposed women. A total of 143 and 49 cancer cases occurred in 97,831 and 34,810 person-years among the exposed and unexposed, respectively. There was no overall excess risk among exposed women when compared with external rates (SIR 1.01; 95% confidence interval [CI] 0.86-1.2). The overall RR comparing exposed with unexposed women was 1.32 (95% CI 0.94-1.8). Breast cancer risk was elevated only among women over 40 years (RR 1.83; 95% CI 1.1-3.2). The CCA SIR among exposed women was nearly 40, and the estimated attack rate through age 39 was 1.6/1,000 women. CCA incidence decreased by over 80% after age 25 when compared with 20-24 years. Excluding CCA and breast cancer, the overall RR was 1.21 (95% CI 0.74-2.0). DES was not associated with excess risks of either endometrial or ovarian cancer. These data suggest that the DES associated increase in CCA incidence remains elevated through the reproductive years. There was no consistent evidence of risk excesses for cancers other than CCA, and breast cancer in older women. Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure. JF - International Journal of Cancer AU - Troisi, Rebecca AU - Hatch, Elizabeth E AU - Titus-Ernstoff, Linda AU - Hyer, Marianne AU - Palmer, Julie R AU - Robboy, Stanley J AU - Strohsnitter, William C AU - Kaufman, Raymond AU - Herbst, Arthur L AU - Hoover, Robert N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, troisir@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 356 EP - 360 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 2 SN - 0020-7136, 0020-7136 KW - diethylstilbestrol KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Ovarian cancer KW - Age KW - Endometrium KW - Prenatal experience KW - Clear cells KW - Chromated copper arsenate KW - Breast cancer KW - Females KW - Diethylstilbestrol KW - Adenocarcinoma KW - H 11000:Diseases/Injuries/Trauma KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cancer+risk+in+women+prenatally+exposed+to+diethylstilbestrol&rft.au=Troisi%2C+Rebecca%3BHatch%2C+Elizabeth+E%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BPalmer%2C+Julie+R%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William+C%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-01&rft.volume=121&rft.issue=2&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22631 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Endometrium; Age; Prenatal experience; Clear cells; Breast cancer; Adenocarcinoma; Diethylstilbestrol; Chromated copper arsenate; Females DO - http://dx.doi.org/10.1002/ijc.22631 ER - TY - JOUR T1 - Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology AN - 20479722; 7499744 AB - Many therapeutic agents are prepared in prodrug forms, which are classified into Type I, II and subtypes A, B based on their sites of conversion. Recently, an increasing number of INDs have appeared as Type II prodrugs that often contain dual tracks of toxicity profile exploration, one on the prodrug and another on the active drug. A comparative toxicology analysis is introduced here to assist reviewers to evaluate the dual toxicity profiles effectively. The analysis helps determine which toxicity is contributed by the prodrug itself, its intermediates, or the active drug itself. As prodrug INDs, or any other new molecular entity (NME) INDs progress into advanced phases of toxicology development, analysis of time-dependent component of toxicity expression, regarding the emergence of new target organs over time, becomes more significant. A strategy is developed to address Pharm/Tox issues such as what duration is required for a toxicity to emerge at the exposure level achieved or dose studied, how many animals in the group are affected, whether the toxicity is a cross-species phenomenon, and whether it is reversible, etc. In conclusion, dual-track comparative toxicology can be useful in the understanding of Type II prodrug's mechanism of toxicity, and that time-dependent toxicology analysis offers means to detecting new toxicity emergence over time. Both approaches could significantly facilitate secondary and tertiary review processes during IND development of a prodrug or NME. JF - Toxicology AU - Wu, K M AU - Farrelly, J G AD - Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States, kueimeng.wu@fda.hhs.gov Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 1 EP - 6 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 236 IS - 1-2 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - prodrugs KW - Reviews KW - Exploration KW - Toxicity KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20479722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Regulatory+perspectives+of+Type+II+prodrug+development+and+time-dependent+toxicity+management%3A+Nonclinical+Pharm%2FTox+analysis+and+the+role+of+comparative+toxicology&rft.au=Wu%2C+K+M%3BFarrelly%2C+J+G&rft.aulast=Wu&rft.aufirst=K&rft.date=2007-07-01&rft.volume=236&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - prodrugs; Reviews; Exploration; Toxicity; Drugs DO - http://dx.doi.org/10.1016/j.tox.2007.04.005 ER - TY - JOUR T1 - Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors AN - 20463923; 9145628 AB - Escherichia coli K92 produces a capsular polysialic acid with alternating alpha 2,8 alpha 2,9 NeuNAc linkages. This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. Synthesis can be blocked by CMP-9-azido-NeuNAc. These results suggest that the K92 PST forms both alpha 2,8 and alpha 2,9 linkages in a successive and nonprocessive fashion. JF - Glycobiology AU - Vionnet, Justine AU - Vann, Willie F AD - Laboratory of Bacterial Polysaccharides , Center for Biologics Evaluation and Research, FDA , Bethesda, MD 20892, wvann@helix.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 735 EP - 743 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 17 IS - 7 SN - 0959-6658, 0959-6658 KW - Microbiology Abstracts B: Bacteriology KW - capsular polysaccharide KW - chain extension KW - polysialyltransferase KW - processivity KW - sialic acid KW - High-performance liquid chromatography KW - Invasiveness KW - oligosaccharides KW - Polymerization KW - Neisseria meningitidis KW - Pathogens KW - Polysaccharides KW - Elongation KW - Escherichia coli KW - polysialic acid KW - Sialic acids KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20463923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=Successive+glycosyltransfer+of+sialic+acid+by+Escherichia+coli+K92+polysialyltransferase+in+elongation+of+oligosialic+acceptors&rft.au=Vionnet%2C+Justine%3BVann%2C+Willie+F&rft.aulast=Vionnet&rft.aufirst=Justine&rft.date=2007-07-01&rft.volume=17&rft.issue=7&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Glycobiology&rft.issn=09596658&rft_id=info:doi/10.1093%2Fglycob%2Fcwm032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Elongation; Invasiveness; Polymerization; oligosaccharides; polysialyltransferase; Pathogens; polysialic acid; Polysaccharides; Sialic acids; Escherichia coli; Neisseria meningitidis DO - http://dx.doi.org/10.1093/glycob/cwm032 ER - TY - JOUR T1 - Completeness of Notification of Tuberculosis in the Netherlands: How Reliable Is Record-Linkage and Capture-Recapture Analysis? AN - 20462163; 7663136 AB - The aim of this study was to describe a systematic process of record-linkage, cross-validation, case- ascertainment and capture-recapture analysis to assess the quality of tuberculosis registers and to estimate the completeness of notification of incident tuberculosis cases in The Netherlands in 1998. After record- linkage and cross-validation 1499 tuberculosis patients were identified, of whom 1298 were notified, resulting in an observed under-notification of 13.4%. After adjustment for possible imperfect record-linkage and remaining false-positive hospital cases observed under-notification was 7.3%. Log-linear capture- recapture analysis initially estimated a total number of 2053 (95% CI 1871-2443) tuberculosis cases, resulting in an estimated under-notification of 36.8%. After adjustment for possible imperfect record- linkage and remaining false-positive hospital cases various capture-recapture models estimated under- notification at 13.6%. One of the reasons for the higher than expected estimated under-notification in a country with a well-organized system of tuberculosis control might be that some tuberculosis cases, e.g. extrapulmonary tuberculosis, are managed by clinicians less familiar with notification of infectious diseases. This study demonstrates the possible impact of violation of assumptions underlying capture- recapture analysis, especially the perfect record-linkage, perfect positive predictive value and absent three-way interaction assumptions. JF - Epidemiology and Infection AU - van hest, NAH AU - Smit, F AU - Baars, HWM AU - de Vries, G AU - de Haas, PEW AU - Westenend, P J AU - Nagelkerke, NJD AU - Richardus, J H AD - Department of Infectious Disease Control, Rotterdam Public Health Service, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1021 EP - 1029 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 135 IS - 6 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - Infectious diseases KW - Mycobacterium KW - Tuberculosis KW - Hospitals KW - Models KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20462163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Completeness+of+Notification+of+Tuberculosis+in+the+Netherlands%3A+How+Reliable+Is+Record-Linkage+and+Capture-Recapture+Analysis%3F&rft.au=van+hest%2C+NAH%3BSmit%2C+F%3BBaars%2C+HWM%3Bde+Vries%2C+G%3Bde+Haas%2C+PEW%3BWestenend%2C+P+J%3BNagelkerke%2C+NJD%3BRichardus%2C+J+H&rft.aulast=van+hest&rft.aufirst=NAH&rft.date=2007-07-01&rft.volume=135&rft.issue=6&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268806007540 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Tuberculosis; Models; Hospitals; Mycobacterium DO - http://dx.doi.org/10.1017/S0950268806007540 ER - TY - JOUR T1 - Characterization of multidrug resistant Salmonella recovered from diseased animals AN - 20440225; 7641286 AB - Three hundred and eighty Salmonella isolates recovered from animal diagnostic samples obtained from four state veterinary diagnostic laboratories (AZ, NC, MO, and TN) between 2002 and 2003 were tested for antimicrobial susceptibilities and further characterized for blaCMY beta-lactamase genes, class 1 integrons and genetic relatedness using PFGE. Forty-seven serovars were identified, the most common being S. Typhimurium (26%), S. Heidelberg (9%), S, Dublin (8%), S. Newport (8%), S. Derby (7%), and S. Choleraesuis (7%). Three hundred and thirteen (82%) isolates were resistant to at least one antimicrobial, and 265 (70%) to three or more antimicrobials. Resistance was most often observed to tetracycline (78%), followed by streptomycin (73%), sulfamethoxazole (68%), and ampicillin (54%), and to a lesser extent chloramphenicol (37%), kanamycin (37%), amoxicillin-clavulanic acid (20%), and ceftiofur (17%). With regards to animal of origin, swine Salmonella isolates displayed the highest rate of resistance, being resistant to at least one antimicrobial (92%), followed by those recovered from turkey (91%), cattle (77%), chicken (68%), and equine (20%). Serovars commonly showing multidrug resistance (MDR) to >=9 antimicrobials were S. Uganda (100%), S. Agona (79%), and S. Newport (62%), compared to S. Heidelberg (11%) and S. Typhimurium (7%). Class-1 integrons were detected in 43% of all isolates, and were found to contain aadA, aadB, dhfr, cmlA and sat1 gene cassettes alone or in various combinations. All ceftiofur resistant isolates (n=66) carried the blaCMY beta-lactamase gene. A total of 230 PFGE patterns were generated among the 380 isolates tested using XbaI, indicating extensive genetic diversity across recovered Salmonella serovars, however, several MDR clones were repeatedly recovered from different diseased animals. JF - Veterinary Microbiology AU - Zhao, S AU - McDermott, P F AU - White, D G AU - Qaiyumi, S AU - Friedman, S L AU - Abbott, J W AU - Glenn, A AU - Ayers, S L AU - Post, K W AU - Fales, W H AU - Wilson, R B AU - Reggiardo, C AU - Walker, R D AD - Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD 20708, United States, shaohua.zhao@FDA.HHS.GOV Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 122 EP - 132 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 123 IS - 1-3 SN - 0378-1135, 0378-1135 KW - Microbiology Abstracts B: Bacteriology KW - Salmonella KW - Antimicrobial resistance KW - Diseased animals KW - Chloramphenicol KW - Sulfamethoxazole KW - Genetic diversity KW - Ampicillin KW - Kanamycin KW - Multidrug resistance KW - Streptomycin KW - Tetracyclines KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20440225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Characterization+of+multidrug+resistant+Salmonella+recovered+from+diseased+animals&rft.au=Zhao%2C+S%3BMcDermott%2C+P+F%3BWhite%2C+D+G%3BQaiyumi%2C+S%3BFriedman%2C+S+L%3BAbbott%2C+J+W%3BGlenn%2C+A%3BAyers%2C+S+L%3BPost%2C+K+W%3BFales%2C+W+H%3BWilson%2C+R+B%3BReggiardo%2C+C%3BWalker%2C+R+D&rft.aulast=Zhao&rft.aufirst=S&rft.date=2007-07-01&rft.volume=123&rft.issue=1-3&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chloramphenicol; Sulfamethoxazole; Ampicillin; Genetic diversity; Multidrug resistance; Kanamycin; Streptomycin; Tetracyclines; Salmonella DO - http://dx.doi.org/10.1016/j.vetmic.2007.03.001 ER - TY - JOUR T1 - Thermally induced filter bias in TEOM mass measurement AN - 20397227; 7553320 AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) have long used stationary tapered element oscillating microbalances (TEOMs registered ) in laboratory settings. They have served to assess the mass concentration of laboratory-generated particulates in experimental dust chambers and they provide a reference method for comparison with other particulate-measuring instruments. Current NIOSH research is focused on further adapting TEOM technology as a wearable personal dust monitor (PDM) for coal mining occupations. This investigation's goal is to help identify, quantify, and provide means for resolving certain TEOM-related error. The present research investigated bias caused by thermal effects on filter assemblies. New filters used in the PDM for 8 h tests show an average positive bias of 25.5 mu g, while similar tests of equivalent filters used in two 1400A model TEOMs show an average positive bias of 34.3 mu g. The derived bias values allow correction of previously collected biased data. Also, preheating the filters for 24 h at 46 degree C shows significant bias reduction, with PDM pre-heated filters subsequently averaging -3.3 mu g and 1400A TEOM filters averaging 5.9 mu g. On a single-point comparison to gravimetric sampling, a 25.5 mu g bias is only significant at low mass loadings. At 2.5 mg, this bias represents a negligible 1% of the mass measurement. If ordinary linear regression is used, the bias is still insignificant. However, if the more valid weighted linear regression is used, it gives more weight to the smaller dependent variable values, which are more impacted by the bias. Consequently, what is 1% bias on a single high-mass value can translate into a larger bias percentage at high-mass values when performing a weighted regression on data that include a large number of low-mass values. JF - Journal of Environmental Monitoring AU - Page, S J AU - Tuchman, D P AU - Vinson, R P AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 760 EP - 767 VL - 9 IS - 7 SN - 1464-0325, 1464-0325 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Filters KW - Occupational safety KW - Coal KW - Particulates KW - Mining KW - Dust KW - Technology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Thermally+induced+filter+bias+in+TEOM+mass+measurement&rft.au=Page%2C+S+J%3BTuchman%2C+D+P%3BVinson%2C+R+P&rft.aulast=Page&rft.aufirst=S&rft.date=2007-07-01&rft.volume=9&rft.issue=7&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb704424k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Filters; Occupational safety; Mining; Particulates; Coal; Dust; Technology DO - http://dx.doi.org/10.1039/b704424k ER - TY - JOUR T1 - Citronellal reactions with ozone and OH radical: Rate constants and gas-phase products detected using PFBHA derivatization AN - 20358902; 7499358 AB - The bimolecular rate constants, k sub(O) sub(H) sub(+) sub(c) sub(i) sub(t) sub(r) sub(o) sub(n) sub(e) sub(l) sub(l) sub(a) sub(l), (150+ /-40)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) and, k sub(O) sub(3) sub(+) sub(c) sub(i) sub(t) sub(r) sub(o) sub(n) sub(e) sub(l) sub(l) sub(a) sub(l), (3.5+ /-1.2)x10 super(-) super(1) super(6)cm super(3)molecule super(-) super(1)s super(-) super(1), were measured using the relative rate technique for the reactions of the hydroxyl radical (OH) and ozone (O sub(3)) with 3,7-dimethyl-6-octen-1-al ((R)-(+)-citronellal) at (297+/-3)K and 1atm total pressure. To more clearly define part of citronellal's indoor environment degradation mechanism, the products of the citronellal+OH and citronellal+O sub(3) reactions were also investigated. The positively identified citronellal/OH and citronellal/O sub(3) reaction products were: 3-methylhexanedial HC(?O)CH sub(2)CH sub(2)CH(CH sub(3))CH sub(2)C(?O)H and 2-oxopropanal (methylglyoxal, CH sub(3)C(?O)C(?O)H). The use of derivatizing agent O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) was used to propose 3-methylhexanedial as a major citronellal/OH and citronellal/O sub(3) reaction product. The elucidation of this reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible citronellal/OH and citronellal/O sub(3) reaction mechanisms based on previously published volatile organic compound/OH and volatile organic compound/O sub(3) gas-phase reaction mechanisms. JF - Atmospheric Environment AU - Harrison, J C AU - Ham, JE AU - Wells, J R AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road Morgantown, WV 26505, USA, ozw0@cdc.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 4482 EP - 4491 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 21 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone measurements KW - Mass spectrometry KW - Hydroxyl photochemistry KW - Indoor environments KW - Volatile organic compounds KW - Hydroxyl radicals KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Citronellal+reactions+with+ozone+and+OH+radical%3A+Rate+constants+and+gas-phase+products+detected+using+PFBHA+derivatization&rft.au=Harrison%2C+J+C%3BHam%2C+JE%3BWells%2C+J+R&rft.aulast=Harrison&rft.aufirst=J&rft.date=2007-07-01&rft.volume=41&rft.issue=21&rft.spage=4482&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2007.01.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Indoor environments; Volatile organic compounds; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.atmosenv.2007.01.042 ER - TY - JOUR T1 - Characterization and expansion of baboon CD4 super(+)CD25 super(+) Treg cells for potential use in a non-human primate xenotransplantation model AN - 20253217; 8009459 AB - Abstract: Background: It is well established that CD4 super(+)CD25 super(+) regulatory T (Treg) cells can modulate allogeneic immune responses. Xenotransplantation, proposed as a means to address the critical shortage of human organs, may also benefit from similar approaches to avert rejection. Baboons are a preferred preclinical animal model for xenogeneic organ transplantation experiments, and the characterization of baboon Treg cells will be beneficial to future tolerance studies in this animal model. Methods: We analyzed CD4 super(+)CD25 super(+) T cells from baboon lymph nodes, spleens, and blood by flow cytometry, then purified and expanded porcine antigen-specific baboon CD4 super(+)CD25 super(high) cells in vitro to evaluate their regulatory activity in the baboon anti-pig xenogeneic responses. Results: CD4 super(+)CD25 super(high) T cells were 1.7%, 3.1%, and 1.9% of baboon splenic, lymph node, and blood T cells, respectively. The CD4 super(+)CD25 super(high) T cells expressed the Treg cell-associated transcription factor, FoxP3. Proliferation-suppression assays using irradiated pig peripheral blood mononuclear cells as stimulators showed that Treg cells suppressed the vigorous baboon CD4 super(+)CD25 super(-) T-cell anti-pig proliferation response and cytokine secretion. Expanded baboon Treg cells suppressed baboon anti-pig CD4 super(+)CD25 super(-) T-cell proliferation similar to 4- to 10-fold more than freshly isolated Treg cells. Expanded Treg cells suppressed proliferation to primary cells from the same pig used for expansion more effectively than proliferation to stimulators from a different strain of pig, suggesting a level of antigen specificity. Conclusion: We demonstrate that baboon Treg cells suppress immune responses to xenogeneic stimulation. These studies suggest that adoptive transfer of expanded Treg cells into transplant recipients may provide an approach to prevent cell-mediated rejection of grafts and potentially induce tolerance in the pig to baboon xenotransplantation preclinical model. JF - Xenotransplantation AU - Porter, Cynthia M AU - Horvath-Arcidiacono, Judith A AU - Singh, Avneesh K AU - Horvath, Keith A AU - Bloom, Eda T AU - Mohiuddin, Muhammad M AD - Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, cynthia.porter@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 298 EP - 308 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 14 IS - 4 SN - 0908-665X, 0908-665X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - baboon KW - immune tolerance KW - regulatory T cells KW - transplantation tolerance KW - xenotransplantation KW - Papio KW - Graft rejection KW - Animal models KW - Spleen KW - CD25 antigen KW - Primates KW - Immunological tolerance KW - Lymph nodes KW - Flow cytometry KW - CD4 antigen KW - Peripheral blood mononuclear cells KW - Foxp3 protein KW - Transcription factors KW - Adoptive transfer KW - Lymphocytes T KW - Cytokines KW - Xenografts KW - Immune response KW - Cell proliferation KW - F 06920:Transplantation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20253217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Characterization+and+expansion+of+baboon+CD4+super%28%2B%29CD25+super%28%2B%29+Treg+cells+for+potential+use+in+a+non-human+primate+xenotransplantation+model&rft.au=Porter%2C+Cynthia+M%3BHorvath-Arcidiacono%2C+Judith+A%3BSingh%2C+Avneesh+K%3BHorvath%2C+Keith+A%3BBloom%2C+Eda+T%3BMohiuddin%2C+Muhammad+M&rft.aulast=Porter&rft.aufirst=Cynthia&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00416.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Graft rejection; Animal models; Spleen; CD25 antigen; Immunological tolerance; Lymph nodes; Flow cytometry; Peripheral blood mononuclear cells; CD4 antigen; Foxp3 protein; Transcription factors; Lymphocytes T; Adoptive transfer; Cytokines; Immune response; Xenografts; Cell proliferation; Papio; Primates DO - http://dx.doi.org/10.1111/j.1399-3089.2007.00416.x ER - TY - JOUR T1 - National policies for xenotransplantation in the USA AN - 20253192; 8009443 AB - Abstract: An overview of xenotransplantation regulatory policies in the USA was presented at the Satellite Symposium, ''Xenotransplantation - Current Standards for Clinical Trials,'' held in conjunction with the World Transplant Congress, Boston, MA, USA 2006. This article summarizes that overview. JF - Xenotransplantation AU - Bloom, Eda T AD - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA, eda.bloom@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 345 EP - 346 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 14 IS - 4 SN - 0908-665X, 0908-665X KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Xenografts KW - Clinical trials KW - Satellites KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20253192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=National+policies+for+xenotransplantation+in+the+USA&rft.au=Bloom%2C+Eda+T&rft.aulast=Bloom&rft.aufirst=Eda&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00396.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Xenografts; Satellites; Clinical trials DO - http://dx.doi.org/10.1111/j.1399-3089.2007.00396.x ER - TY - JOUR T1 - Particle size-dependent radical generation from wildland fire smoke AN - 20168149; 7499745 AB - Firefighting, along with construction, mining and agriculture, ranks among the most dangerous occupations. In addition, the work environment of firefighters is unlike that of any other occupation, not only because of the obvious physical hazards but also due to the respiratory and systemic health hazards of smoke inhalation resulting from combustion. A significant amount of research has been devoted to studying municipal firefighters; however, these studies may not be useful in wildland firefighter exposures, because the two work environments are so different. Not only are wildland firefighters exposed to different combustion products, but their exposure profiles are different. The combustion products wildland firefighters are exposed to can vary greatly in characteristics due to the type and amount of material being burned, soil conditions, temperature and exposure time. Smoke inhalation is one of the greatest concerns for firefighter health and it has been shown that the smoke consists of a large number of particles. These smoke particles contain intermediates of hydrogen, carbon and oxygen free radicals, which may pose a potential health risk. Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. Samples were collected in discrete aerodynamic particle sizes from a wildfire in Alaska, preserved and then shipped to our laboratory for analysis. Electron spin resonance was used to measure carbon-centered as well as hydroxyl radicals produced by a Fenton-like reaction with wildfire smoke. Further study of reactive oxygen species was conducted using analysis of cellular H sub(2)O sub(2) generation, lipid peroxidation of cellular membranes and DNA damage. Results demonstrate that coarse size-range particles contained more carbon radicals per unit mass than the ultrafine particles; however, the ultrafine particles generated more ?OH radicals in the acellular Fenton-like reaction. The ultrafine particles also caused significant increases in H sub(2)O sub(2) production by monocytes and lipid peroxidation. All particle sizes showed the ability to cause DNA damage. These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size. JF - Toxicology AU - Leonard, S S AU - Castranova, V AU - Chen, B T AU - Schwegler-Berry, D AU - Hoover, M AU - Piacitelli, C AU - Gaughan, D M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, SEL5@cdc.gov Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 103 EP - 113 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 236 IS - 1-2 SN - 0300-483X, 0300-483X KW - Sustainability Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Inhalation KW - Agriculture KW - wildfire KW - firefighter services KW - Combustion products KW - Lipids KW - Soil temperature KW - Particulates KW - Hydrogen KW - Soil KW - Carbon KW - Reactive oxygen species KW - Hydrogen peroxide KW - Monocytes KW - USA, Alaska KW - Particle size KW - Fires KW - Free radicals KW - Surface area KW - Temperature KW - agriculture KW - oxygen free radicals KW - Toxicity KW - peroxidation KW - Lipid peroxidation KW - Hydroxyl radicals KW - Combustion KW - Smoke KW - Oxygen KW - DNA damage KW - Wildfire KW - DNA KW - Mining KW - surface area KW - M3 1010:Issues in Sustainable Development KW - X 24490:Other KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20168149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Particle+size-dependent+radical+generation+from+wildland+fire+smoke&rft.au=Leonard%2C+S+S%3BCastranova%2C+V%3BChen%2C+B+T%3BSchwegler-Berry%2C+D%3BHoover%2C+M%3BPiacitelli%2C+C%3BGaughan%2C+D+M&rft.aulast=Leonard&rft.aufirst=S&rft.date=2007-07-01&rft.volume=236&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Agriculture; Particle size; Inhalation; Fires; Combustion products; Surface area; Free radicals; Soil temperature; oxygen free radicals; Hydrogen; Toxicity; Lipid peroxidation; Combustion; Soil; Smoke; DNA damage; Wildfire; Carbon; Reactive oxygen species; Hydrogen peroxide; Mining; Monocytes; wildfire; firefighter services; Lipids; agriculture; Temperature; Particulates; peroxidation; Hydroxyl radicals; Oxygen; DNA; surface area; USA, Alaska DO - http://dx.doi.org/10.1016/j.tox.2007.04.008 ER - TY - JOUR T1 - Antibacterial activities of some mosses including Hylocomium splendens from South Western British Columbia AN - 19975896; 7580605 AB - The antibacterial activity of methanol extracts of ten moss species and fractions prepared from 80% methanol extract of Hylocomium splendens were evaluated by disk diffusion method. Nine moss species showed antibacterial activity against Gram (+) bacteria, in particular H. splendens and its ethyl acetate fractions showed stronger activity. Enhancement of antibacterial activity against Staphylococci by UV-A light irradiation was demonstrated in the extracts of Bartramia pomiformis, Ceratodon purpureus and Neckera douglasii. JF - Fitoterapia AU - Kang, S J AU - Kim, SH AU - Liu, P AU - Jovel, E AU - Towers, GHN AD - Korea Food and Drug Administration, Jinheungno, Seoul, 122-704, Republic of Korea, sapium@yahoo.com Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 373 EP - 376 VL - 78 IS - 5 SN - 0367-326X, 0367-326X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Hylocomium splendens KW - U.V. radiation KW - Antibacterial activity KW - Ceratodon purpureus KW - Neckera KW - Methanol KW - Ethyl acetate KW - Bartramia pomiformis KW - Diffusion KW - Light effects KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fitoterapia&rft.atitle=Antibacterial+activities+of+some+mosses+including+Hylocomium+splendens+from+South+Western+British+Columbia&rft.au=Kang%2C+S+J%3BKim%2C+SH%3BLiu%2C+P%3BJovel%2C+E%3BTowers%2C+GHN&rft.aulast=Kang&rft.aufirst=S&rft.date=2007-07-01&rft.volume=78&rft.issue=5&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Fitoterapia&rft.issn=0367326X&rft_id=info:doi/10.1016%2Fj.fitote.2007.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - U.V. radiation; Antibacterial activity; Ethyl acetate; Methanol; Diffusion; Light effects; Hylocomium splendens; Ceratodon purpureus; Neckera; Bartramia pomiformis DO - http://dx.doi.org/10.1016/j.fitote.2007.03.008 ER - TY - JOUR T1 - Genome Sequence of a Clinical Isolate of Campylobacter jejuni from Thailand AN - 19861413; 7462134 AB - Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence. JF - Infection and Immunity AU - Poly, Frederic AU - Read, Timothy AU - Tribble, David R AU - Baqar, Shahida AU - Lorenzo, Maria AU - Guerry, Patricia AD - Enteric Diseases. Biological Defense Research Directorates, Naval Medical Research Center, Silver Spring, Maryland. Food and Drug Administration, Beltsville, Maryland Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 3425 EP - 3433 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 7 SN - 0019-9567, 0019-9567 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Clinical isolates KW - Epithelial cells KW - Diarrhea KW - Data processing KW - Nucleotide sequence KW - Inflammation KW - Virulence KW - Mustela KW - Campylobacter jejuni KW - Carbohydrates KW - Gene mapping KW - N 14845:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19861413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Genome+Sequence+of+a+Clinical+Isolate+of+Campylobacter+jejuni+from+Thailand&rft.au=Poly%2C+Frederic%3BRead%2C+Timothy%3BTribble%2C+David+R%3BBaqar%2C+Shahida%3BLorenzo%2C+Maria%3BGuerry%2C+Patricia&rft.aulast=Poly&rft.aufirst=Frederic&rft.date=2007-07-01&rft.volume=75&rft.issue=7&rft.spage=3425&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virulence; Clinical isolates; Genomes; Epithelial cells; Data processing; Diarrhea; Nucleotide sequence; Carbohydrates; Gene mapping; Inflammation; Mustela; Campylobacter jejuni ER - TY - JOUR T1 - Characterization of the Zinc-Containing Metalloprotease Encoded by zpx and Development of a Species-Specific Detection Method for Enterobacter sakazakii AN - 19861283; 7459696 AB - Enterobacter sakazakii causes a severe form of neonatal meningitis that occurs as sporadic cases as well as outbreaks. The disease has been epidemiologically associated with consumption of reconstituted, dried infant formulas. Very little information is available regarding pathogenicity of the organism and production of virulence factors. Clinical and environmental strains were screened for production of factors which have activity against Chinese hamster ovary (CHO) cells in tissue culture. Polymyxin B lysate and sonicate preparations but not culture supernatants from the strains caused "rounding" of CHO cells. Subsequent studies showed that the CHO cell-rounding factor is a proteolytic enzyme that has activity against azocasein. The cell-bound protease was isolated by using a combination of polymyxin B lysis, followed by sonication of cells harvested from tryptone broth. The protease was purified to homogeneity by sequential ammonium sulfate precipitation, gel filtration chromatography with Sephadex G-100, hydrophobic interaction chromatography with phenyl-Sepharose CL-4B, and a second gel filtration with Sephadex G-100. In addition to activity against azocasein, the purified protease also exhibits activity against azocoll and insoluble casein but not elastin. The protease has a molecular weight of 38,000 and an isoelectric point of 4.4. It is heat labile and for maximal activity against azocasein has an optimum temperature of 37 degree C and a pH range of 5 to 7. Proteolytic activity is inhibited by ortho-phenanthroline and Zincov but is not affected by phenylmethylsulfonyl fluoride, N-ethylmaleimide, and trypsin inhibitors, which demonstrates that the protease is a zinc-containing metalloprotease. The metalloprotease does not hemagglutinate chicken or sheep erythrocytes. Twenty-three to 27 of the first 42 N-terminal amino acid residues of the metalloprotease are identical to proteases produced by Serratia proteamaculans, Pectobacterium carotovorum, and Anabaena sp. PCR analysis using primers designed from a consensus nucleotide sequence showed that 135 E. sakazakii strains possessed the metalloprotease gene, zpx, and 25 non-E. sakazakii strains did not. The cloned zpx gene of strain 29544 consists of 1,026 nucleotides, and the deduced amino acid sequence of the metalloprotease has 341 amino acid residues, which corresponds to a theoretical protein size of 37,782 with a theoretical pI of 5.23. The sequence possesses three well-characterized zinc-binding and active-site motifs present in other bacterial zinc metalloproteases. JF - Applied and Environmental Microbiology AU - Kothary, M H AU - McCardell, BA AU - Frazar, C D AU - Deer, D AU - Tall, B D AD - U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 4142 EP - 4151 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 13 SN - 0099-2240, 0099-2240 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Proteolysis KW - Infant formulas KW - virulence factors KW - Nucleotide sequence KW - Erythrocytes KW - Anabaena KW - Cell culture KW - Hydrophobicity KW - Serratia proteamaculans KW - Azocasein KW - Meningitis KW - Pectobacterium KW - Pathogenicity KW - Ammonium sulfate KW - Molecular weight KW - phenylmethylsulfonyl fluoride KW - Polymerase chain reaction KW - Elastin KW - pH effects KW - Proteolytic enzymes KW - Temperature effects KW - Isoelectric points KW - Trypsin KW - Chromatography KW - Enterobacter sakazakii KW - polymyxin B KW - Tissue culture KW - Precipitation KW - Sonication KW - Metalloproteinase KW - Filtration KW - Heat KW - Primers KW - Amino acid sequence KW - N 14810:Methods KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19861283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Characterization+of+the+Zinc-Containing+Metalloprotease+Encoded+by+zpx+and+Development+of+a+Species-Specific+Detection+Method+for+Enterobacter+sakazakii&rft.au=Kothary%2C+M+H%3BMcCardell%2C+BA%3BFrazar%2C+C+D%3BDeer%2C+D%3BTall%2C+B+D&rft.aulast=Kothary&rft.aufirst=M&rft.date=2007-07-01&rft.volume=73&rft.issue=13&rft.spage=4142&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Infant formulas; virulence factors; Nucleotide sequence; Erythrocytes; Hydrophobicity; Cell culture; Azocasein; Meningitis; Ammonium sulfate; Pathogenicity; Molecular weight; Elastin; Polymerase chain reaction; phenylmethylsulfonyl fluoride; pH effects; Proteolytic enzymes; Temperature effects; Isoelectric points; Trypsin; Chromatography; Precipitation; Tissue culture; polymyxin B; Sonication; Metalloproteinase; Filtration; Heat; Primers; Amino acid sequence; Pectobacterium; Enterobacter sakazakii; Anabaena; Serratia proteamaculans ER - TY - JOUR T1 - Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey AN - 19858927; 7465380 AB - Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death. Additional studies are needed to determine if ketamine anesthesia results in brain cell death in the nonhuman primate and if so, to begin to define the stage of development and the duration of ketamine anesthesia necessary to produce brain cell death. Rhesus monkeys (N = 3 for each treatment and control group) at three stages of development (122 days of gestation and 5 and 35 postnatal days [PNDs]) were administered ketamine intravenously for 24 h to maintain a surgical anesthetic plane, followed by a 6-h withdrawal period. Similar studies were performed in PND 5 animals with 3 h of ketamine anesthesia. Animals were subsequently perfused and brain tissue processed for analyses. Ketamine (24-h infusion) produced a significant increase in the number of caspase 3-, Fluoro-Jade C- and silver stain-positive cells in the cortex of gestational and PND 5 animals but not in PND 35 animals. Electron microscopy indicated typical nuclear condensation and fragmentation in some neuronal cells, and cell body swelling was observed in others indicating that ketamine-induced neuronal cell death is most likely both apoptotic and necrotic in nature. Ketamine increased N-methyl-D-aspartate (NMDA) receptor NR1 subunit messenger RNA in the frontal cortex where enhanced cell death was apparent. Earlier developmental stages (122 days of gestation and 5 PNDs) appear more sensitive to ketamine-induced neuronal cell death than later in development (35 PNDs). However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey. JF - Toxicological Sciences AU - Slikker, William Jr AU - Zou, Xiaoju AU - Hotchkiss, Charlotte E AU - Divine, Rebecca L AU - Sadovova, Natalya AU - Twaddle, Nathan C AU - Doerge, Daniel R AU - Scallet, Andrew C AU - Patterson, Tucker A AU - Hanig, Joseph P AU - Paule, Merle G AU - Wang, Cheng AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration. Bionetics Corporation. Toxicologic Pathology Associates. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, Arkansas 72079. Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food & Drug Administration, Silver Spring, Maryland 20993 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 145 EP - 158 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 1 SN - 1096-6080, 1096-6080 KW - Rhesus macaque KW - Rhesus monkey KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - N-Methyl-D-aspartic acid receptors KW - Apoptosis KW - Pediatrics KW - Brain KW - Cortex (frontal) KW - Anesthetics KW - Developmental stages KW - Primates KW - Glutamic acid receptors KW - Glutamic acid receptors (ionotropic) KW - mRNA KW - Cell death KW - Anesthesia KW - Cell body KW - Gestation KW - Ketamine KW - Macaca mulatta KW - Condensation KW - Caspase KW - Electron microscopy KW - X 24310:Pharmaceuticals KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19858927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Ketamine-Induced+Neuronal+Cell+Death+in+the+Perinatal+Rhesus+Monkey&rft.au=Slikker%2C+William+Jr%3BZou%2C+Xiaoju%3BHotchkiss%2C+Charlotte+E%3BDivine%2C+Rebecca+L%3BSadovova%2C+Natalya%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel+R%3BScallet%2C+Andrew+C%3BPatterson%2C+Tucker+A%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BWang%2C+Cheng&rft.aulast=Slikker&rft.aufirst=William&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - N-Methyl-D-aspartic acid receptors; Apoptosis; Pediatrics; Brain; Developmental stages; Anesthetics; Cortex (frontal); Glutamic acid receptors; Glutamic acid receptors (ionotropic); mRNA; Cell death; Anesthesia; Gestation; Cell body; Ketamine; Caspase; Condensation; Electron microscopy; Macaca mulatta; Primates ER - TY - JOUR T1 - A Polyomic Approach To Elucidate the Fluoranthene-Degradative Pathway in Mycobacterium vanbaalenii PYR-1 AN - 19850960; 7462521 AB - Mycobacterium vanbaalenii PYR-1 is capable of degrading a wide range of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs), including fluoranthene. We used a combination of metabolomic, genomic, and proteomic technologies to investigate fluoranthene degradation in this strain. Thirty-seven fluoranthene metabolites including potential isomers were isolated from the culture medium and analyzed by high-performance liquid chromatography, gas chromatography-mass spectrometry, and UV-visible absorption. Total proteins were separated by one-dimensional gel and analyzed by liquid chromatography-tandem mass spectrometry in conjunction with the M. vanbaalenii PYR-1 genome sequence (http://jgi.doe.gov), which resulted in the identification of 1,122 proteins. Among them, 53 enzymes were determined to be likely involved in fluoranthene degradation. We integrated the metabolic information with the genomic and proteomic results and proposed pathways for the degradation of fluoranthene. According to our hypothesis, the oxidation of fluoranthene is initiated by dioxygenation at the C-1,2, C-2,3, and C-7,8 positions. The C-1,2 and C-2,3 dioxygenation routes degrade fluoranthene via fluorene-type metabolites, whereas the C-7,8 routes oxidize fluoranthene via acenaphthylene-type metabolites. The major site of dioxygenation is the C-2,3 dioxygenation route, which consists of 18 enzymatic steps via 9-fluorenone-1-carboxylic acid and phthalate with the initial ring-hydroxylating oxygenase, NidA3B3, oxidizing fluoranthene to fluoranthene cis-2,3-dihydrodiol. Nonspecific monooxygenation of fluoranthene with subsequent O methylation of dihydroxyfluoranthene also occurs as a detoxification reaction. JF - Journal of Bacteriology AU - Kweon, Ohgew AU - Kim, Seong-Jae AU - Jones, Richard C AU - Freeman, James P AU - Adjei, Michael D AU - Edmondson, Ricky D AU - Cerniglia, Carl E AD - Division of Microbiology. Division of Systems Toxicology. Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079 Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 4635 EP - 4647 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 13 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Detoxification KW - High-performance liquid chromatography KW - Genomes KW - Fluoranthene KW - Mycobacterium vanbaalenii KW - Polycyclic aromatic hydrocarbons KW - Biodegradation KW - Nucleotide sequence KW - Enzymes KW - Metabolites KW - Mass spectroscopy KW - Isomers KW - Phthalic acid KW - Gas chromatography KW - Oxidation KW - genomics KW - proteomics KW - Methylation KW - Oxygenase KW - metabolomics KW - N 14820:DNA Metabolism & Structure KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=A+Polyomic+Approach+To+Elucidate+the+Fluoranthene-Degradative+Pathway+in+Mycobacterium+vanbaalenii+PYR-1&rft.au=Kweon%2C+Ohgew%3BKim%2C+Seong-Jae%3BJones%2C+Richard+C%3BFreeman%2C+James+P%3BAdjei%2C+Michael+D%3BEdmondson%2C+Ricky+D%3BCerniglia%2C+Carl+E&rft.aulast=Kweon&rft.aufirst=Ohgew&rft.date=2007-07-01&rft.volume=189&rft.issue=13&rft.spage=4635&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; High-performance liquid chromatography; Detoxification; Fluoranthene; Polycyclic aromatic hydrocarbons; Biodegradation; Nucleotide sequence; Enzymes; Metabolites; Mass spectroscopy; Phthalic acid; Isomers; Gas chromatography; Oxidation; proteomics; genomics; Oxygenase; Methylation; metabolomics; Mycobacterium vanbaalenii ER - TY - JOUR T1 - Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry AN - 19786670; 7516723 AB - The quinolones, oxolinic acid (OXO), flumequine (FLU), and nalidixic acid (NAL), are antibacterial drugs effective against Gram-negative bacteria. Quinolones are used in both human and veterinary medicine, but are currently not approved by the U.S. Food and Drug Administration for use in food fish. A liquid chromatography-fluorescence (LC-FL) method was developed to determine OXO, FLU, and NAL residues in shrimp. An additional liquid chromatography-mass spectrometry (LC-MSn) method was created to confirm these residues using the same sample extract. Samples were prepared with a simple ethyl acetate extraction followed by solvent exchange into 0.2% formic acid and cleaned-up with hexane. Reverse phase chromatography was used to separate the three compounds in both procedures. For the LC-FL determinative method, fluorescence emission was monitored at 369nm with excitation at 327nm. With electrospray ionization, the three most abundant ions from the MS3 product ion spectrum were used to identify OXO, FLU, and NAL in the confirmation procedure. Shrimp samples fortified at levels ranging from 7.5 to 100ngg-1 were used to validate both methods. JF - Analytica Chimica Acta AU - Karbiwnyk, Christine M AU - Carr, Lori E AU - Turnipseed, Sherri B AU - Andersen, Wendy C AU - Miller, Keith E AD - Animal Drugs Research Center, Food and Drug Administration, Denver, CO, United States, christine.karbiwnyk@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 257 EP - 263 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com] VL - 596 IS - 2 SN - 0003-2670, 0003-2670 KW - Crabs KW - Microbiology Abstracts B: Bacteriology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Quinolones KW - Residue analysis KW - Shrimp KW - Fluorescence KW - Mass spectrometry KW - Confirmation KW - Disease control KW - Antibiotics KW - Mass spectroscopy KW - Veterinary medicine KW - Gram-negative bacteria KW - Nalidixic acid KW - Marine crustaceans KW - Drugs KW - Marine KW - Flumequine KW - Ions KW - Decapoda KW - Solvents KW - Spectrometry KW - Food fish KW - USA KW - Formic acid KW - Liquid chromatography KW - Ethyl acetate KW - Marine aquaculture KW - Oxolinic acid KW - Ionization KW - n-Hexane KW - Q1 08587:Diseases of Cultured Organisms KW - Q3 08587:Diseases of Cultured Organisms KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19786670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Determination+of+quinolone+residues+in+shrimp+using+liquid+chromatography+with+fluorescence+detection+and+residue+confirmation+by+mass+spectrometry&rft.au=Karbiwnyk%2C+Christine+M%3BCarr%2C+Lori+E%3BTurnipseed%2C+Sherri+B%3BAndersen%2C+Wendy+C%3BMiller%2C+Keith+E&rft.aulast=Karbiwnyk&rft.aufirst=Christine&rft.date=2007-07-01&rft.volume=596&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2007.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Fluorescence; Disease control; Antibiotics; Marine aquaculture; Drugs; Marine crustaceans; Food fish; Ions; Flumequine; Quinolones; Solvents; Mass spectroscopy; Spectrometry; Veterinary medicine; Formic acid; Liquid chromatography; Gram-negative bacteria; Ethyl acetate; Nalidixic acid; Oxolinic acid; Ionization; n-Hexane; Decapoda; USA; Marine DO - http://dx.doi.org/10.1016/j.aca.2007.06.018 ER - TY - JOUR T1 - Extracellular structure of polysialic acid explored by on cell solution NMR AN - 19780324; 7533167 AB - The capsular polysaccharide of the pathogens Neisseria meningitidis serogroup B and of Escherichia coli K1, alpha (2 arrow right 8) polysialic acid (PSA), is unusual, because when injected into adult humans, it generates little or no antibody. In contrast, people infected with these pathogens generate specific serum antibodies. A structural study on cells is used to address this anomaly by characterizing antigen structures in vivo. We introduce on cell multidimensional solution NMR spectroscopy for direct observation of PSA on E. coli bacteria. Using super(13)C, super(15)N-labeled PSA, we applied a combination of heteronuclear NMR methods, such as heteronuclear single quantum coherence, HNCA, and HNCO, in vivo. Analysis reveals that free and cell-bound PSA are structurally similar, indicating that the poor immunogenicity of PSA is not due to major structural differences between cells and purified PSA. The super(13)C linewidths of PSA on cells are 2 to 3 times larger than the corresponding ones in free PSA. The possible implications of the differences between free and on cell PSA are discussed. In addition, we demonstrate the suitability of the method for in vivo kinetic studies. JF - Proceedings of the National Academy of Sciences, USA AU - Azurmendi, Hugo F AU - Vionnet, Justine AU - Wrightson, Lauren AU - Trinh, Loc B AU - Shiloach, Joseph AU - Freedberg, Daron I AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 11557 EP - 11561 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 28 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Antibodies KW - Immunogenicity KW - Kinetics KW - Magnetic resonance spectroscopy KW - Escherichia coli KW - N.M.R. KW - Neisseria meningitidis KW - Pathogens KW - polysialic acid KW - Capsular polysaccharides KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19780324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Extracellular+structure+of+polysialic+acid+explored+by+on+cell+solution+NMR&rft.au=Azurmendi%2C+Hugo+F%3BVionnet%2C+Justine%3BWrightson%2C+Lauren%3BTrinh%2C+Loc+B%3BShiloach%2C+Joseph%3BFreedberg%2C+Daron+I&rft.aulast=Azurmendi&rft.aufirst=Hugo&rft.date=2007-07-01&rft.volume=104&rft.issue=28&rft.spage=11557&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Antibodies; Immunogenicity; Magnetic resonance spectroscopy; Kinetics; N.M.R.; polysialic acid; Pathogens; Capsular polysaccharides; Escherichia coli; Neisseria meningitidis ER - TY - JOUR T1 - Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine AN - 19735891; 7531670 AB - Flagellin is a key component of the flagella of many pathogens, including Pseudomonas aeruginosa. Flagellin is an attractive vaccine candidate because it is readily produced and manipulated as a recombinant protein and has intrinsic adjuvant activity mediated through TLR5. Although DNA vaccines encoding native Pseudomonas B-type (FliC) or A-type (FlaA) flagellin are strongly immunogenic, the resultant Ab response interferes with the interaction of homologous flagellin with TLR5. This reduces the ability of the host to clear homologous, but not heterologous, flagellin-expressing P. aeruginosa. To circumvent this problem, a DNA vaccine encoding a mutant FliC R90A flagellin was developed. The mutant Ag encoded by this vaccine was highly immunogenic, but its ability to interact with TLR5 was reduced by >100-fold. Vaccination with this flagellin mutant DNA vaccine induced cross-reactive Abs against both FliC and FlaA, but few Abs capable of interfering with TLR5 activation. The flagellin mutant DNA vaccine provided excellent protection against both FliC- and FlaA-expressing P. aeruginosa. These findings suggest that vaccines against flagellated pathogens should avoid inducing Abs against TLR5 and raise the possibility that flagellated bacteria evade host elimination by facilitating the production of Abs that reduce the host's ability to mount an innate immune response. JF - Journal of Immunology AU - Saha, Sukumar AU - Takeshita, Fumihiko AU - Matsuda, Tomoko AU - Jounai, Nao AU - Kobiyama, Kouji AU - Matsumoto, Tetsuya AU - Sasaki, Shin AU - Yoshida, Atsushi AU - Xin, Ke-Qin AU - Klinman, Dennis M AU - Uematsu, Satoshi AU - Ishii, Ken J AU - Akira, Shizuo AU - Okuda, Kenji AD - Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. Department of Microbiology, Tokyo Medical University School of Medicine, Tokyo, Japan. Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of Host Defense, Research Institute for Microbial Diseases, Osaka, Japan. Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka, Japan Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1147 EP - 1154 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 2 SN - 0022-1767, 0022-1767 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - FlaA protein KW - Pathogens KW - Adjuvants KW - Antibody response KW - DNA vaccines KW - TLR5 protein KW - Immunogenicity KW - Immune response KW - Pseudomonas aeruginosa KW - Flagellin KW - Toll-like receptors KW - Flagella KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Blocking+of+the+TLR5+Activation+Domain+Hampers+Protective+Potential+of+Flagellin+DNA+Vaccine&rft.au=Saha%2C+Sukumar%3BTakeshita%2C+Fumihiko%3BMatsuda%2C+Tomoko%3BJounai%2C+Nao%3BKobiyama%2C+Kouji%3BMatsumoto%2C+Tetsuya%3BSasaki%2C+Shin%3BYoshida%2C+Atsushi%3BXin%2C+Ke-Qin%3BKlinman%2C+Dennis+M%3BUematsu%2C+Satoshi%3BIshii%2C+Ken+J%3BAkira%2C+Shizuo%3BOkuda%2C+Kenji&rft.aulast=Saha&rft.aufirst=Sukumar&rft.date=2007-07-01&rft.volume=179&rft.issue=2&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - FlaA protein; TLR5 protein; DNA vaccines; Immunogenicity; Antibody response; Immune response; Adjuvants; Pathogens; Flagellin; Toll-like receptors; Flagella; Pseudomonas aeruginosa ER - TY - JOUR T1 - Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide AN - 19734207; 7529437 AB - Organic peroxides, widely used in the chemical and pharmaceutical industries, can act as skin tumor promoters and cause epidermal hyperplasia. They are also known to trigger free radical generation. The present study evaluated the effect of cumene hydroperoxide (Cum-OOH) on the induction of activator protein-1 (AP-1), which is linked to the expression of genes regulating cell proliferation, growth and transformation. Previously, we reported that topical exposure to Cum-OOH caused formation of free radicals and oxidative stress in the skin of vitamin E-deficient mice. The present study used JB6 P+ mouse epidermal cells and AP-1-luciferase reporter transgenic mice to identify whether exposure to Cum-OOH caused activation of AP-1, oxidative stress, depletion of antioxidants and tumor formation during two-stage carcinogenesis. In vitro studies found that exposure to Cum-OOH reduced the level of glutathione (GSH) in mouse epidermal cells (JB6 P+) and caused the induction of AP-1. Mice primed with dimethyl-benz[a]anthracene (DMBA) were topically exposed to Cum-OOH (82.6 mu mol) or the positive control, 12-O-tetradecanoylphorbol-13-acetate (TPA, 17 nmol), twice weekly for 29 weeks. Activation of AP-1 in skin was detected as early as 2 weeks following Cum-OOH or TPA exposure. No AP-1 expression was found 19 weeks after initiation. Papilloma formation was observed in both the DMBA-TPA- and DMBA-Cum-OOH-exposed animals, whereas skin carcinomas were found only in the DMBA-Cum-OOH-treated mice. A greater accumulation of peroxidative products (thiobarbituric acid-reactive substances), inflammation and decreased levels of GSH and total antioxidant reserves were also observed in the skin of DMBA-Cum-OOH-exposed mice. These results suggest that Cum-OOH-induced carcinogenesis is accompanied by increased AP-1 activation and changes in antioxidant status. JF - Carcinogenesis AU - Murray, A R AU - Kisin, E R AU - Kommineni, C AU - Vallyathan, V AU - Castranova, V AU - Shvedova, A A AD - Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26505, USA. Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, m/s 2015, 1095 Willowdale Road, Morgantown, WV 26505, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1582 EP - 1588 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Transformation KW - Antioxidants KW - Glutathione KW - Free radicals KW - Activator protein 1 KW - Tumors KW - Transgenic mice KW - cumene hydroperoxide KW - TPA KW - 12-O-Tetradecanoylphorbol-13-acetate KW - skin carcinoma KW - Inflammation KW - Promoters KW - Hyperplasia KW - Oxidative stress KW - Vitamins KW - Transcription factors KW - 9,10-Dimethyl-1,2-benzanthracene KW - Carcinogenesis KW - peroxide KW - Pharmaceuticals KW - Papilloma KW - Cell proliferation KW - X 24310:Pharmaceuticals KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19734207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Pro%2Fantioxidant+status+and+AP-1+transcription+factor+in+murine+skin+following+topical+exposure+to+cumene+hydroperoxide&rft.au=Murray%2C+A+R%3BKisin%2C+E+R%3BKommineni%2C+C%3BVallyathan%2C+V%3BCastranova%2C+V%3BShvedova%2C+A+A&rft.aulast=Murray&rft.aufirst=A&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1582&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Antioxidants; Glutathione; Free radicals; Activator protein 1; Tumors; Transgenic mice; cumene hydroperoxide; 12-O-Tetradecanoylphorbol-13-acetate; TPA; Inflammation; skin carcinoma; Promoters; Hyperplasia; Oxidative stress; 9,10-Dimethyl-1,2-benzanthracene; Transcription factors; Vitamins; Carcinogenesis; Pharmaceuticals; peroxide; Cell proliferation; Papilloma ER - TY - JOUR T1 - Organisms Designated as Nocardia asteroides Drug Pattern Type VI Are Members of the Species Nocardia cyriacigeorgica AN - 19728639; 7531482 AB - Nocardia cyriacigeorgica has recently been described as an "emerging" pathogen. However, DNA-DNA hybridization results confirm that Nocardia asteroides drug pattern type VI, which has long been recognized as a common and significant pathogen in the United States, belongs to the species N. cyriacigeorgica. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 2257 EP - 2259 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 7 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Pathogens KW - Drugs KW - Nocardia asteroides KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Organisms+Designated+as+Nocardia+asteroides+Drug+Pattern+Type+VI+Are+Members+of+the+Species+Nocardia+cyriacigeorgica&rft.au=Conville%2C+Patricia+S%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2007-07-01&rft.volume=45&rft.issue=7&rft.spage=2257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pathogens; Drugs; Nocardia asteroides ER - TY - JOUR T1 - Urban Feral Pigeons (Columba livia) as a Source for Air- and Waterborne Contamination with Enterocytozoon bieneusi Spores AN - 19714830; 7459724 AB - This study demonstrated that a person with 30 min of occupational or nonoccupational exposure to urban feral pigeons, such as exposure through the cleaning of surfaces contaminated with pigeon excrement, could inhale approximately 3.5 x 10 super(3) Enterocytozoon bieneusi spores and that 1.3 x 10 super(3) spores could be inhaled by a nearby person. JF - Applied and Environmental Microbiology AU - Graczyk, Thaddeus K AU - Sunderland, Deirdre AU - Rule, Ana M AU - da Silva, Alexandre J AU - Moura, Iaci NS AU - Tamang, Leena AU - Girouard, Autumn S AU - Schwab, Kellogg J AU - Breysse, Patrick N AD - Division of Environmental Health Engineering, Department of Environmental Health Sciences. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205. Division of Parasitic Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Public Services, Atlanta, Georgia 30341. Atlanta Research and Education Foundation and Atlanta VA Medical Center, Decatur, Georgia 30333 Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 4357 EP - 4358 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 13 SN - 0099-2240, 0099-2240 KW - Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Contamination KW - Enterocytozoon bieneusi KW - Spores KW - occupational exposure KW - Columba livia KW - Occupational exposure KW - K 03410:Animal Diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19714830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Urban+Feral+Pigeons+%28Columba+livia%29+as+a+Source+for+Air-+and+Waterborne+Contamination+with+Enterocytozoon+bieneusi+Spores&rft.au=Graczyk%2C+Thaddeus+K%3BSunderland%2C+Deirdre%3BRule%2C+Ana+M%3Bda+Silva%2C+Alexandre+J%3BMoura%2C+Iaci+NS%3BTamang%2C+Leena%3BGirouard%2C+Autumn+S%3BSchwab%2C+Kellogg+J%3BBreysse%2C+Patrick+N&rft.aulast=Graczyk&rft.aufirst=Thaddeus&rft.date=2007-07-01&rft.volume=73&rft.issue=13&rft.spage=4357&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Contamination; Spores; Occupational exposure; occupational exposure; Enterocytozoon bieneusi; Columba livia ER - TY - JOUR T1 - Supplementary breaks and stretching exercises for data entry operators: A follow-up field study AN - 19710780; 7512418 AB - Background This study expanded previous NIOSH-IRS research examining the effects of rest breaks and stretching exercises on symptoms and performance in data-entry workers. Methods All workers spent 4 weeks with conventional breaks (two 15 min breaks per day) and 4 weeks with supplementary breaks (two 15 min breaks plus four 5 min breaks per day). One-half were assigned at random to a group instructed to perform brief stretching exercises during breaks. The remainder comprised the no stretching (control) group. Results 51 workers (stretch group n=21; no stretch group n=30) completed the study symptom questionnaires. Discomfort and eyestrain were significantly lower with supplementary breaks, and supplementary breaks attenuated accumulation of discomfort and eyestrain during work sessions. Data-entry speed was significantly faster with supplementary breaks so that work output was maintained, despite replacing 20 min of work time with break time. In the stretch group, workers reported stretching during only 25% of conventional breaks and 39% of supplementary breaks, and no significant effects of stretching on discomfort or performance were observed. Conclusions These results provide further converging evidence that supplementary breaks reliably minimize discomfort and eyestrain without impairing productivity. Low compliance in performing stretches prevented valid assessment of stretching effects. Further research on stretching exercises and exercise compliance is warranted. Am. J. Ind. Med. 50:519-527, 2007. Published 2007 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Galinsky, Traci AU - Swanson, Naomi AU - Sauter, Steven AU - Dunkin, Robin AU - Hurrell, Joseph AU - Schleifer, Lawrence AD - National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, tgalinsky@cdc.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 519 EP - 527 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 50 IS - 7 SN - 0271-3586, 0271-3586 KW - data entry KW - Physical Education Index; Health & Safety Science Abstracts KW - Work capacity KW - Physical activity KW - Compliance KW - Automation KW - Surveys KW - Exercise KW - Working conditions KW - Stretching KW - Evaluation KW - Speed KW - Rest KW - Performance KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Supplementary+breaks+and+stretching+exercises+for+data+entry+operators%3A+A+follow-up+field+study&rft.au=Galinsky%2C+Traci%3BSwanson%2C+Naomi%3BSauter%2C+Steven%3BDunkin%2C+Robin%3BHurrell%2C+Joseph%3BSchleifer%2C+Lawrence&rft.aulast=Galinsky&rft.aufirst=Traci&rft.date=2007-07-01&rft.volume=50&rft.issue=7&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20472 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Speed; Work capacity; Compliance; Rest; Surveys; Performance; Exercise; Stretching; Physical activity; Automation; Working conditions; Ergonomics; Occupational health DO - http://dx.doi.org/10.1002/ajim.20472 ER - TY - JOUR T1 - Prior antibiotics and risk of antibiotic-resistant community-acquired urinary tract infection: a case-control study AN - 19688640; 7462238 AB - BACKGROUND: To assess the effect of previous antibiotic use on the risk of a resistant Escherichia coli urinary tract infection (UTI), we undertook a case-control study with prospective measurement of outcomes in 10 general practices in the UK. METHODS: Urinary samples from all patients with symptoms suggestive of UTIs were sought, and those with a laboratory-proven E. coli infection were interviewed and their medical records examined. Case patients were those with ampicillin- or trimethoprim-resistant infections and control patients had infections that were susceptible to antibiotics, including ampicillin and trimethoprim. RESULTS: Risk of ampicillin-resistant E. coli infection in 903 patients was associated with amoxicillin prescriptions of greater than or equal to 7 days duration in the previous 1 month [odds ratio (OR) = 3.91, 95% CI 1.64-9.34] and previous 2-3 months (2.29, 1.12-4.70) before illness onset. For prescriptions <7 days duration, there was no statistically significant association. Higher doses of amoxicillin were associated with lower risk of ampicillin resistance. For trimethoprim-resistant E. coli infections, the OR was 8.44 (3.12-22.86) for prescriptions of trimethoprim of greater than or equal to 7 days in the previous month and 13.91 (3.32-58.31) for the previous 2-3 months. For trimethoprim prescriptions of <7 days, the OR was 4.03 (1.69-9.59) for the previous month but prescribing in earlier periods was not significantly associated with resistance. CONCLUSIONS: Within the community setting, exposure to antibiotics is a strong risk factor for a resistant E. coli UTI. High-dose, shorter-duration antibiotic regimens may reduce the pressure on the emergence of antibiotic resistance. JF - Journal of Antimicrobial Chemotherapy AU - Hillier, Sharon AU - Roberts, Zoe AU - Dunstan, Frank AU - Butler, Chris AU - Howard, Anthony AU - Palmer, Stephen AD - Department of Epidemiology, Statistics and Public Health, Centre for Health Sciences Research, Cardiff University, Neuadd Meirionydd, Heath Park, Cardiff CF14 4YS, UK. Department of General Practice, Centre for Health Sciences Research, Cardiff University, Neuadd Meirionydd, Heath Park, Cardiff CF14 4YS, UK. National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 92 EP - 99 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Trimethoprim KW - Amoxicillin KW - medical records KW - Training KW - Statistical analysis KW - Ampicillin KW - Antibiotics KW - Urinary tract KW - Infection KW - Risk factors KW - Escherichia coli KW - Pressure KW - Antibiotic resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19688640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Prior+antibiotics+and+risk+of+antibiotic-resistant+community-acquired+urinary+tract+infection%3A+a+case-control+study&rft.au=Hillier%2C+Sharon%3BRoberts%2C+Zoe%3BDunstan%2C+Frank%3BButler%2C+Chris%3BHoward%2C+Anthony%3BPalmer%2C+Stephen&rft.aulast=Hillier&rft.aufirst=Sharon&rft.date=2007-07-01&rft.volume=60&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amoxicillin; Trimethoprim; Training; medical records; Risk factors; Statistical analysis; Ampicillin; Antibiotics; Urinary tract; Pressure; Infection; Antibiotic resistance; Escherichia coli ER - TY - JOUR T1 - Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice AN - 19687312; 7465391 AB - Topical exposure to nanoscale materials is likely from a variety of sources including sunscreens and cosmetics. Because the in vivo disposition of nanoscale materials is not well understood, we have evaluated the distribution of quantum dots (QDs) following intradermal injection into female SKH-1 hairless mice as a model system for determining tissue localization following intradermal infiltration. The QD (CdSe core, CdS capped, poly[ethylene glycol] coated, 37 nm diameter, 621 nm fluorescence emission) were injected intradermally (ID) on the right dorsal flank. Within minutes following intradermal injection, the highly UV fluorescent QD could be observed moving from the injection sites apparently through the lymphatic duct system to regional lymph nodes. Residual fluorescent QD remained at the site of injection until necropsy at 24 h. Quantification of cadmium and selenium levels after 0, 4, 8, 12, or 24 h in multiple tissues, using inductively coupled plasma mass spectrometry (ICP-MS), showed a time-dependent loss of cadmium from the injection site, and accumulation in the liver, regional draining lymph nodes, kidney, spleen, and hepatic lymph node. Fluorescence microscopy corroborated the ICP-MS results regarding the tissue distribution of QD. The results indicated that (1) ID injected nanoscale QD remained as a deposit in skin and penetrated the surrounding viable subcutis, (2) QD were distributed to draining lymph nodes through the sc lymphatics and to the liver and other organs, and (3) sentinel organs are effective locations for monitoring transdermal penetration of nanoscale materials into animals. JF - Toxicological Sciences AU - Gopee, Neera V AU - Roberts, Dean W AU - Webb, Peggy AU - Cozart, Christy R AU - Siitonen, Paul H AU - Warbritton, Alan R AU - Yu, William W AU - Colvin, Vicki L AU - Walker, Nigel J AU - Howard, Paul C AD - National Center for Toxicological Research. National Toxicology Program Center for Phototoxicology, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Toxicology Pathology Associates, Jefferson, Arkansas 72079. Center for Biological and Environmental Nanotechnology and Department of Chemistry, Rice University, Houston, Texas, 77251. National Institute of Environmental Health Sciences, National Institutes of Health, and the National Toxicology Program, Research Triangle Park, North Carolina, 27709 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 249 EP - 257 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Deposits KW - Autopsy KW - Fluorescence KW - Skin KW - Spleen KW - Cosmetics KW - Disposition KW - Mass spectroscopy KW - Lymph nodes KW - Selenium KW - Quantum dots KW - Kidney KW - Liver KW - Sunscreens KW - Cadmium KW - Hairless KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Migration+of+Intradermally+Injected+Quantum+Dots+to+Sentinel+Organs+in+Mice&rft.au=Gopee%2C+Neera+V%3BRoberts%2C+Dean+W%3BWebb%2C+Peggy%3BCozart%2C+Christy+R%3BSiitonen%2C+Paul+H%3BWarbritton%2C+Alan+R%3BYu%2C+William+W%3BColvin%2C+Vicki+L%3BWalker%2C+Nigel+J%3BHoward%2C+Paul+C&rft.aulast=Gopee&rft.aufirst=Neera&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autopsy; Deposits; Skin; Fluorescence; Spleen; Disposition; Cosmetics; Lymph nodes; Mass spectroscopy; Selenium; Quantum dots; Liver; Kidney; Sunscreens; Hairless; Cadmium ER - TY - JOUR T1 - Protection against Chromium (VI)-Induced Oxidative Stress and Apoptosis by Nrf2. Recruiting Nrf2 into the Nucleus and Disrupting the Nuclear Nrf2/Keap1 Association AN - 19686226; 7465395 AB - Chromium (Cr) (VI) is a major environmental toxic metal and a human carcinogen. The molecular events mediating cellular responses to Cr(VI) are not clear at present. We show that Cr(VI) potently induced apoptosis and production of reactive oxygen species (ROS) in mouse hepa1c1c7 cells in a concentration-dependent manner. Mouse embryonic fibroblast cells lacking Nrf2 exhibited elevated ROS production and apoptosis, which were markedly further increased by Cr(VI), suggesting a protective role of Nrf2 against Cr(VI) toxicity. Protection by Nrf2 correlated with induction of cytoprotective genes Ho-1 and Nqo1. Induction of the genes by Cr(VI) involved inhibition of ubiquitination of Nrf2 and accumulation of Nrf2 into the nucleus. In the nucleus, treatment with Cr(VI), but not phenolic antioxidant tert-butylhydroquinone, librates Nrf2 from the Nrf2/Keap1 association and recruits Nrf2 to the antioxidant response elements (ARE) located in the enhancers of Ho-1 and Nqo1. Activation of Nrf2 by Cr(VI) was accompanied by the nuclear translocation and deubiquitination of Keap1 implicating recycling of Keap1 in Nrf2 signaling. Thus, protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 by the toxic metal, transcription of ARE-driven genes, and reduction of ROS production. JF - Toxicological Sciences AU - He, Xiaoqing AU - Lin, Gary X AU - Chen, Michael G AU - Zhang, Jennifer X AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, Mailstop 3014, 1095 Willowdale Road, West Virginia 26505 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 298 EP - 309 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Antioxidants KW - Apoptosis KW - Chromium KW - Heavy metals KW - Regulatory sequences KW - Transcription KW - Carcinogens KW - Toxicity KW - Recycling KW - Fibroblasts KW - Nuclear transport KW - ubiquitination KW - Enhancers KW - Reactive oxygen species KW - Oxidative stress KW - phenolic compounds KW - Embryos KW - NAD(P)H dehydrogenase (quinone) KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Protection+against+Chromium+%28VI%29-Induced+Oxidative+Stress+and+Apoptosis+by+Nrf2.+Recruiting+Nrf2+into+the+Nucleus+and+Disrupting+the+Nuclear+Nrf2%2FKeap1+Association&rft.au=He%2C+Xiaoqing%3BLin%2C+Gary+X%3BChen%2C+Michael+G%3BZhang%2C+Jennifer+X%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Apoptosis; Antioxidants; Chromium; Heavy metals; Regulatory sequences; Transcription; Toxicity; Carcinogens; Recycling; Fibroblasts; Enhancers; ubiquitination; Nuclear transport; Reactive oxygen species; Oxidative stress; phenolic compounds; NAD(P)H dehydrogenase (quinone); Embryos; Signal transduction ER - TY - JOUR T1 - Lead in pharmaceutical products and dietary supplements AN - 19673680; 7435516 AB - The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products. Lead concentrations of 45 products were measured with inductively-coupled plasma mass spectrometry. Six products had lead concentrations greater than 100 parts per billion (ppb), and the highest measured concentration was 500ppb. The average mass of lead delivered to consumers by all products examined in this study when taken as directed was 0.22 micrograms per day, which is expected to increase the blood lead level of an adult by less than 1%. Five products were found to deliver more than 1 mu g of lead per day when used as directed. Current tolerable lead limits in pharmaceutical substances vary widely, and in some cases exceed 10,000ppb. The products examined in this study have lead concentrations far below these levels. However, in light of recent research demonstrating adverse effects in both children and adults from low level lead exposure, current lead limits for pharmaceutical substances are unacceptably high. Uniform lead limits that reflect current manufacturing capabilities are needed to insure the lowest achievable exposure to lead from these products. JF - Regulatory Toxicology and Pharmacology AU - Kauffman, J F AU - Westenberger, B J AU - Robertson, J D AU - Guthrie, J AU - Jacobs, A AU - Cummins, S K AD - Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, USA, John.Kauffman@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 128 EP - 134 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 48 IS - 2 SN - 0273-2300, 0273-2300 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Consumer products KW - dietary supplements KW - Heavy metals KW - Mass spectrometry KW - Children KW - Lead KW - Mass spectroscopy KW - Blood KW - Dietary supplements KW - Pharmaceuticals KW - Consumers KW - Side effects KW - H 14000:Toxicology KW - X 24360:Metals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19673680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Lead+in+pharmaceutical+products+and+dietary+supplements&rft.au=Kauffman%2C+J+F%3BWestenberger%2C+B+J%3BRobertson%2C+J+D%3BGuthrie%2C+J%3BJacobs%2C+A%3BCummins%2C+S+K&rft.aulast=Kauffman&rft.aufirst=J&rft.date=2007-07-01&rft.volume=48&rft.issue=2&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; Dietary supplements; Pharmaceuticals; Consumers; Children; Side effects; Mass spectroscopy; Lead; dietary supplements; Consumer products; Heavy metals; Mass spectrometry DO - http://dx.doi.org/10.1016/j.yrtph.2007.03.001 ER - TY - JOUR T1 - Dinitrophenol and obesity: An early twentieth-century regulatory dilemma AN - 19603084; 7435514 AB - In the early 1930s, the industrial chemical dinitrophenol found widespread favor as a weight-loss drug, due principally to the work of Maurice Tainter, a clinical pharmacologist from Stanford University. Unfortunately the compound's therapeutic index was razor thin and it was not until thousands of people suffered irreversible harm that mainstream physicians realized that dinitrophenol's risks outweighed its benefits and abandoned its use. Yet, it took passage of the Food, Drug, and Cosmetic Act in 1938 before federal regulators had the ability to stop patent medicine men from selling dinitrophenol to Americans lured by the promise of a drug that would safely melt one's fat away. JF - Regulatory Toxicology and Pharmacology AU - Colman, E AD - Office of Drug Evaluation II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Room 3360, Silver Spring, MD 20993, USA, eric.colman@fda.hhs.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 115 EP - 117 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 48 IS - 2 SN - 0273-2300, 0273-2300 KW - Dinitrophenol KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Hazards KW - Obesity KW - Patents KW - obesity KW - Drugs KW - Side effects KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Dinitrophenol+and+obesity%3A+An+early+twentieth-century+regulatory+dilemma&rft.au=Colman%2C+E&rft.aulast=Colman&rft.aufirst=E&rft.date=2007-07-01&rft.volume=48&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Patents; Hazards; obesity; Drugs; Side effects DO - http://dx.doi.org/10.1016/j.yrtph.2007.03.006 ER - TY - JOUR T1 - New Respirator Fit Test Panels Representing the Current U.S. Civilian Work Force AN - 19584072; 8501980 AB - The fit test panels currently used for respirator research, design, and certification are 25-subject panels developed by Los Alamos National Laboratory (LANL) and are based on data from the 1967 and 1968 anthropometric surveys of U.S. Air Force personnel. Military data do not represent the great diversity in face size and shape seen in civilian populations. In addition, the demographics of the U.S. population have changed over the last 30 years. Thus, it is necessary to assess and refine the LANL fit test panels. This paper presents the development of new respirator fit test panels representative of current U.S. civilian workers based on an anthropometric survey of 3997 respirator users conducted in 2003. One panel was developed using face length and face width (bivariate approach) and weighting subjects to match the age and race distribution of the U.S. population as determined from the 2000 census. Another panel was developed using the first two principal components obtained from a set of 10 facial dimensions (age and race adjusted). These 10 dimensions are associated with respirator fit and leakage and can predict the remaining face dimensions well. Respirators designed to fit these panels are expected to accommodate more than 95% of the current U.S. civilian workers. Both panels are more representative of the U.S. population than the existing LANL panel and may be appropriate for testing both half-masks and full-facepiece respirators. Respirator manufacturers, standards development organizations, and government respirator certification bodies need to select the appropriate fit test panel for their particular needs. The bivariate panel is simpler to use than the principal component analysis (PCA) panel and is most similar to the LANL panel currently used. The inclusion of the eight additional facial measurements allows the PCA panel to provide better criteria for excluding extreme face sizes from being used. Because the boundaries of the two new panels are significantly different from the LANL panel, it may be necessary to develop new respirator sizing systems. A new five-category sizing system is proposed. JF - Journal of Occupational and Environmental Hygiene AU - Zhuang, Ziqing AU - Bradtmiller, Bruce AU - Shaffer, Ronald E AD - National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 647 EP - 659 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 9 SN - 1545-9624, 1545-9624 KW - fit testing KW - Health & Safety Science Abstracts KW - census KW - demography KW - Age KW - Leakage KW - principal components analysis KW - USA, New Mexico, Los Alamos KW - Protective equipment KW - certification KW - USA KW - research design KW - Respirators KW - Military KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19584072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=New+Respirator+Fit+Test+Panels+Representing+the+Current+U.S.+Civilian+Work+Force&rft.au=Zhuang%2C+Ziqing%3BBradtmiller%2C+Bruce%3BShaffer%2C+Ronald+E&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2007-07-01&rft.volume=4&rft.issue=9&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701497538 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - demography; census; certification; Age; Leakage; principal components analysis; research design; Military; Respirators; Protective equipment; Occupational exposure; USA; USA, New Mexico, Los Alamos DO - http://dx.doi.org/10.1080/15459620701497538 ER - TY - JOUR T1 - Determining the Spatial Variability of Personal Sampler Inlet Locations AN - 19580739; 8501984 AB - This article examines the spatial variability of dust concentrations within a coal miner's breathing zone and the impact of sampling location at the cap lamp, nose, and lapel. Tests were conducted in the National Institute for Safety and Health Pittsburgh Research Laboratory full-scale, continuous miner gallery using three prototype personal dust monitors (PDM). The dust masses detected by the PDMs were used to calculate the percentage difference of dust mass between the cap lamp and the nose and between the lapel and the nose. The calculated percentage differences of the masses ranged from plus 12% to minus 25%. Breathing zone tests were also conducted in four underground coal mines using the torso of a mannequin to simulate a miner. Coal mine dust was sampled with multi-cyclone sampling cans mounted directly in front of the mannequin near the cap lamp, nose, and lapel. These four coal mine tests found that the spatial variability of dust levels and imprecision of the current personal sampler is a greater influence than the sampler location within the breathing zone. However, a one-sample t-test of this data did find that the overall mean value of the cap lamp/nose ratio was not significantly different than 1 (p-value = 0.21). However, when applied to the overall mean value of the lapel/nose ratio there was a significant difference from 1 (p-value < .0001). This finding is important because the lapel has always been the sampling location for coal mine dust samples. But these results suggest that the cap location is slightly more indicative of what is breathed through the nose area. JF - Journal of Occupational and Environmental Hygiene AU - Vinson, Robert AU - Volkwein, Jon AU - McWilliams, Linda AD - Pittsburgh Research Laboratory, NIOSH, Pittsburgh, Pennsylvania Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 708 EP - 714 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Prototypes KW - prototypes KW - Coal KW - Mines KW - Dust KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Determining+the+Spatial+Variability+of+Personal+Sampler+Inlet+Locations&rft.au=Vinson%2C+Robert%3BVolkwein%2C+Jon%3BMcWilliams%2C+Linda&rft.aulast=Vinson&rft.aufirst=Robert&rft.date=2007-07-01&rft.volume=4&rft.issue=9&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701540618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Prototypes; prototypes; Coal; Mines; Occupational exposure; Dust DO - http://dx.doi.org/10.1080/15459620701540618 ER - TY - JOUR T1 - Assessment of Noise Exposure for Indoor and Outdoor Firing Ranges AN - 19580236; 8501983 AB - The National Institute for Occupational Safety and Health (NIOSH) received an employee request for a health hazard evaluation of a Special Weapons Assault Team (SWAT) in January 2002. The department was concerned about noise exposures and potential hearing damage from weapons training on their indoor and outdoor firing ranges. NIOSH investigators conducted noise sampling with an acoustic mannequin head and 1/4 -inch microphone to characterize the noise exposures that officers might experience during small arms qualification and training when wearing a variety of hearing protection devices provided by the department. The peak sound pressure levels for the various weapons ranged from 156 to 170 decibels (dB SPL), which are greater than the recommended allowable 140 dB SPL exposure guideline from NIOSH. The earplugs, ear muffs, and customized SWAT team hearing protectors provided between 25 and 35 dB of peak reduction. Double hearing protection (plugs plus muffs) added 15-20 dB of peak reduction. JF - Journal of Occupational and Environmental Hygiene AU - Murphy, William J AU - Tubbs, Randy L AD - Division of Applied Research and Technology, Hearing Loss Prevention Team, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 688 EP - 697 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 9 SN - 1545-9624, 1545-9624 KW - firing ranges KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Head KW - Training KW - Acoustics KW - microphones KW - Noise levels KW - Ear KW - Sound pressure KW - Weapons KW - guidelines KW - Sound KW - Noise KW - Sampling KW - Hearing KW - Pressure KW - Environmental hygiene KW - H 3000:Environment and Ecology KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - P 7000:NOISE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Assessment+of+Noise+Exposure+for+Indoor+and+Outdoor+Firing+Ranges&rft.au=Murphy%2C+William+J%3BTubbs%2C+Randy+L&rft.aulast=Murphy&rft.aufirst=William&rft.date=2007-07-01&rft.volume=4&rft.issue=9&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701537390 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Head; Acoustics; Noise; Sound; Ear; Sampling; Pressure; Hearing; Environmental hygiene; Weapons; guidelines; Training; microphones; Noise levels; Sound pressure DO - http://dx.doi.org/10.1080/15459620701537390 ER - TY - JOUR T1 - Concerning Sampler Wall Deposits in the Chemical Analysis of Airborne Metals AN - 19578318; 8501978 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Harper, Martin AU - Demange, Martine AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - D81 EP - D86 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Air pollution KW - Metals KW - Air sampling KW - Chemical analysis KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19578318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Concerning+Sampler+Wall+Deposits+in+the+Chemical+Analysis+of+Airborne+Metals&rft.au=Ashley%2C+Kevin%3BHarper%2C+Martin%3BDemange%2C+Martine&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2007-07-01&rft.volume=4&rft.issue=9&rft.spage=D81&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701493149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Air pollution; Metals; Air sampling; Chemical analysis; Occupational exposure DO - http://dx.doi.org/10.1080/15459620701493149 ER - TY - JOUR T1 - Research article: Tuberculosis Control Among People in U.S. Immigration and Customs Enforcement Custody AN - 19562314; 8791305 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Schneider, Diana L AU - Lobato, Mark N AD - Division of Immigration Health Services, U.S. Public Health Service, Washington, DC, Diana.Schneider@dhs.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 9 EP - 14 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 33 IS - 1 SN - 0749-3797, 0749-3797 KW - Microbiology Abstracts B: Bacteriology KW - Immigration KW - Mycobacterium KW - Tuberculosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19562314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Research+article%3A+Tuberculosis+Control+Among+People+in+U.S.+Immigration+and+Customs+Enforcement+Custody&rft.au=Schneider%2C+Diana+L%3BLobato%2C+Mark+N&rft.aulast=Schneider&rft.aufirst=Diana&rft.date=2007-07-01&rft.volume=33&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.02.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immigration; Tuberculosis; Mycobacterium DO - http://dx.doi.org/10.1016/j.amepre.2007.02.044 ER - TY - JOUR T1 - A Population-Based Job Exposure Matrix for Power-Frequency Magnetic Fields AN - 19538459; 8501985 AB - A population-based job exposure matrix (JEM) was developed to assess personal exposures to power-frequency magnetic fields (MF) for epidemiologic studies. The JEM compiled 2317 MF measurements taken on or near workers by 10 studies in the United States, Sweden, New Zealand, Finland, and Italy. A database was assembled from the original data for six studies plus summary statistics grouped by occupation from four other published studies. The job descriptions were coded into the 1980 Standard Occupational Classification system (SOC) and then translated to the 1980 job categories of the U.S. Bureau of the Census (BOC). For each job category, the JEM database calculated the arithmetic mean, standard deviation, geometric mean, and geometric standard deviation of the workday-average MF magnitude from the combined data. Analysis of variance demonstrated that the combining of MF data from the different sources was justified, and that the homogeneity of MF exposures in the SOC occupations was comparable to JEMs for solvents and particulates. BOC occupation accounted for 30% of the MF variance (p << 10-6), and the contrast (ratio of the between-job variance to the total of within- and between-job variances) was 88%. Jobs lacking data had their exposures inferred from measurements on similar occupations. The JEM provided MF exposures for 97% of the person-months in a population-based case-control study and 95% of the jobs on death certificates in a registry study covering 22 states. Therefore, we expect this JEM to be useful in other population-based epidemiologic studies. [Supplementary materials are available for this article. Go to the publisher's online edition of the Journal of Occupational and Environmental Hygiene for the following free Supplemental resources: Appendices A-D and Formula Proofs.] JF - Journal of Occupational and Environmental Hygiene AU - Bowman, Joseph D AU - Touchstone, Jennifer A AU - Yost, Michael G AD - Engineering and Physical Hazards Branch, NIOSH, Cincinnati, Ohio Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 715 EP - 728 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 9 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - census KW - Classification systems KW - Mortality KW - Data processing KW - Finland KW - Solvents KW - Statistical analysis KW - Particulates KW - Italy KW - Mathematics KW - Magnetic fields KW - Databases KW - Workers KW - USA KW - Standard deviation KW - Census KW - New Zealand KW - Occupational exposure KW - Sweden KW - Environmental hygiene KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19538459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Population-Based+Job+Exposure+Matrix+for+Power-Frequency+Magnetic+Fields&rft.au=Bowman%2C+Joseph+D%3BTouchstone%2C+Jennifer+A%3BYost%2C+Michael+G&rft.aulast=Bowman&rft.aufirst=Joseph&rft.date=2007-07-01&rft.volume=4&rft.issue=9&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701528001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Classification systems; Workers; Databases; Magnetic fields; Standard deviation; Data processing; Statistical analysis; Solvents; Census; Mathematics; Environmental hygiene; census; Mortality; Particulates; Occupational exposure; USA; Finland; New Zealand; Italy; Sweden DO - http://dx.doi.org/10.1080/15459620701528001 ER - TY - JOUR T1 - The U.S. Food and Drug Administration's Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer AN - 19454440; 7531918 AB - Several studies have reported an inverse association between tomato and/or lycopene intake and the risk of some types of cancer. In 2004, the U.S. Food and Drug Administration (FDA) received two petitions for qualified health claims regarding tomatoes, lycopene, and the risk reduction for some forms of cancer. Health claims that characterize the relationship between a food or food component and a disease or health-related condition require premarket approval by FDA to be included on the labels of conventional foods and dietary supplements. Here we describe FDA's review of the scientific data for tomato and/or lycopene intake with respect to risk reduction for certain forms of cancer. The FDA found no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer. The FDA also found no credible evidence for an assocaition between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer. The FDA found very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers. JF - Journal of the National Cancer Institute AU - Kavanaugh, Claudine J AU - Trumbo, Paula R AU - Ellwood, Kathleen C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1074 EP - 1085 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Lycopersicon esculentum KW - risk reduction KW - USA KW - dietary supplements KW - Reviews KW - FDA KW - Nutrients KW - Drugs KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=The+U.S.+Food+and+Drug+Administration%27s+Evidence-Based+Review+for+Qualified+Health+Claims%3A+Tomatoes%2C+Lycopene%2C+and+Cancer&rft.au=Kavanaugh%2C+Claudine+J%3BTrumbo%2C+Paula+R%3BEllwood%2C+Kathleen+C&rft.aulast=Kavanaugh&rft.aufirst=Claudine&rft.date=2007-07-01&rft.volume=99&rft.issue=14&rft.spage=1074&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - risk reduction; dietary supplements; Reviews; FDA; Nutrients; Drugs; Cancer; Lycopersicon esculentum; USA ER - TY - JOUR T1 - Leveraging Philanthropic Investments To Advance Policy Change AN - 1504422362; 201406554 AB - The current Assistant Secretary for Aging, of the U.S. Department of Health and Human Services, describes how the department's Administration on Aging has leveraged the investments of a number of private foundations and entered into a partnership with them to develop, test, and support the initiatives that were eventually included in the Bush administration's Choices for Independence Reauthorization Proposal. An important example of government-foundation partnerships, Choices for Independence was embraced by Congress, and incorporated into the federal Older Americans Act. Adapted from the source document. JF - Generations AU - Carbonell, Josefina G AD - Department of Health and Human Services, Washington, D.C. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 29 EP - 34 PB - American Society on Aging, San Francisco CA VL - 31 IS - 2 SN - 0738-7806, 0738-7806 KW - Human Services KW - Bush Administration KW - Aging KW - Choices KW - Health Behavior KW - Legislative Bodies KW - article KW - 1022: social differentiation; generations/intergenerational relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504422362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Generations&rft.atitle=Leveraging+Philanthropic+Investments+To+Advance+Policy+Change&rft.au=Carbonell%2C+Josefina+G&rft.aulast=Carbonell&rft.aufirst=Josefina&rft.date=2007-07-01&rft.volume=31&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Generations&rft.issn=07387806&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2014-03-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GENREC N1 - SubjectsTermNotLitGenreText - Choices; Aging; Legislative Bodies; Human Services; Health Behavior; Bush Administration ER - TY - JOUR T1 - Petition to request an exemption from 100 percent identity testing of dietary ingredients: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements. Interim final rule. AN - 68123238; 17674485 AB - The Food and Drug Administration (FDA) is issuing an interim final rule (IFR) that sets forth a procedure for requesting an exemption from the requirement in the final rule "Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements," published elsewhere in this issue of the Federal Register, that the manufacturer conduct at least one appropriate test or examination to verify the identity of any component that is a dietary ingredient. This IFR allows for submission to, and review by, FDA of an alternative to the required 100 percent identity testing of components that are dietary ingredients, provided certain conditions are met and establishes a requirement for retention of records relating to the FDA's response to an exemption request. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2007/06/25/ PY - 2007 DA - 2007 Jun 25 SP - 34959 EP - 34969 VL - 72 IS - 121 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - Food Contamination -- prevention & control KW - Food Handling -- legislation & jurisprudence KW - Humans KW - Food Packaging -- legislation & jurisprudence KW - Food Labeling -- legislation & jurisprudence KW - Food Industry -- legislation & jurisprudence KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Dietary Supplements -- standards KW - Quality Control KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Petition+to+request+an+exemption+from+100+percent+identity+testing+of+dietary+ingredients%3A+Current+Good+Manufacturing+Practice+in+Manufacturing%2C+Packaging%2C+Labeling%2C+or+Holding+Operations+for+Dietary+Supplements.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-06-25&rft.volume=72&rft.issue=121&rft.spage=34959&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. Final rule. AN - 68123085; 17674484 AB - The Food and Drug Administration (FDA) is issuing a final rule regarding current good manufacturing practice (CGMP) for dietary supplements. The final rule establishes the minimum CGMPs necessary for activities related to manufacturing, packaging, labeling, or holding dietary supplements to ensure the quality of the dietary supplement. The final rule is one of many actions related to dietary supplements that we are taking to promote and protect the public health. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2007/06/25/ PY - 2007 DA - 2007 Jun 25 SP - 34751 EP - 34958 VL - 72 IS - 121 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - Food Contamination -- prevention & control KW - Public Health KW - Sanitation -- legislation & jurisprudence KW - Humans KW - Food Handling -- legislation & jurisprudence KW - Food Industry -- legislation & jurisprudence KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Food Packaging -- legislation & jurisprudence KW - Dietary Supplements -- standards KW - Quality Control KW - Food Labeling -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Current+good+manufacturing+practice+in+manufacturing%2C+packaging%2C+labeling%2C+or+holding+operations+for+dietary+supplements.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-06-25&rft.volume=72&rft.issue=121&rft.spage=34751&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. AN - 70605547; 17482224 AB - Exposure of mice to single-walled carbon nanotubes (SWCNTs) induces an unusually robust pulmonary inflammatory response with an early onset of fibrosis, which is accompanied by oxidative stress and antioxidant depletion. The role of specific components of the antioxidant protective system, specifically vitamin E, the major lipid-soluble antioxidant, in the SWCNT-induced reactions has not been characterized. We used C57BL/6 mice, maintained on vitamin E-sufficient or vitamin E-deficient diets, to explore and compare the pulmonary inflammatory reactions to aspired SWCNTs. The vitamin E-deficient diet caused a 90-fold depletion of alpha-tocopherol in the lung tissue and resulted in a significant decline of other antioxidants (GSH, ascorbate) as well as accumulation of lipid peroxidation products. A greater decrease of pulmonary antioxidants was detected in SWCNT-treated vitamin E-deficient mice as compared to controls. Lowered levels of antioxidants in vitamin E-deficient mice were associated with a higher sensitivity to SWCNT-induced acute inflammation (total number of inflammatory cells, number of polymorphonuclear leukocytes, released LDH, total protein content and levels of pro-inflammatory cytokines, TNF-alpha and IL-6) and enhanced profibrotic responses (elevation of TGF-beta and collagen deposition). Exposure to SWCNTs markedly shifted the ratio of cleaved to full-length extracellular superoxide dismutase (EC-SOD). Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies. JF - Toxicology and applied pharmacology AU - Shvedova, Anna A AU - Kisin, Elena R AU - Murray, Ashley R AU - Gorelik, Olga AU - Arepalli, Sivaram AU - Castranova, Vincent AU - Young, Shih-Hong AU - Gao, Fei AU - Tyurina, Yulia Y AU - Oury, Tim D AU - Kagan, Valerian E AD - Pathology/Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA. ats1@cdc.gov Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 339 EP - 348 VL - 221 IS - 3 SN - 0041-008X, 0041-008X KW - Antioxidants KW - 0 KW - Cytokines KW - Nanotubes, Carbon KW - Particulate Matter KW - Sod3 protein, mouse KW - EC 1.15.1.1 KW - Superoxide Dismutase KW - Glutathione KW - GAN16C9B8O KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Animals KW - Lipid Peroxidation -- immunology KW - Glutathione -- metabolism KW - Cytokines -- immunology KW - Lipid Peroxidation -- drug effects KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- drug effects KW - Cytokines -- metabolism KW - Mice KW - Glutathione -- drug effects KW - Antioxidants -- metabolism KW - Oxidative Stress -- drug effects KW - Mice, Inbred C57BL KW - Ascorbic Acid -- metabolism KW - Oxidative Stress -- immunology KW - Female KW - Vitamin E Deficiency -- complications KW - Particulate Matter -- toxicity KW - Vitamin E Deficiency -- immunology KW - Lung Diseases -- chemically induced KW - Foreign-Body Reaction -- immunology KW - Foreign-Body Reaction -- chemically induced KW - Foreign-Body Reaction -- metabolism KW - Lung Diseases -- metabolism KW - Particulate Matter -- immunology KW - Lung Diseases -- complications KW - Nanotubes, Carbon -- toxicity KW - Lung Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70605547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Vitamin+E+deficiency+enhances+pulmonary+inflammatory+response+and+oxidative+stress+induced+by+single-walled+carbon+nanotubes+in+C57BL%2F6+mice.&rft.au=Shvedova%2C+Anna+A%3BKisin%2C+Elena+R%3BMurray%2C+Ashley+R%3BGorelik%2C+Olga%3BArepalli%2C+Sivaram%3BCastranova%2C+Vincent%3BYoung%2C+Shih-Hong%3BGao%2C+Fei%3BTyurina%2C+Yulia+Y%3BOury%2C+Tim+D%3BKagan%2C+Valerian+E&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2007-06-15&rft.volume=221&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-25 N1 - Date created - 2007-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1983 Feb 15;221(1):281-90 [6830261] Am J Respir Cell Mol Biol. 2006 Sep;35(3):289-97 [16574944] Prostaglandins Leukot Med. 1987 Mar;26(3):265-80 [3554268] Ann N Y Acad Sci. 1989;570:121-35 [2698101] J Biol Chem. 1991 Apr 5;266(10):6188-94 [2007576] Ann Clin Biochem. 1991 Sep;28 ( Pt 5):504-8 [1958055] Proc Soc Exp Biol Med. 1992 Jun;200(2):271-6 [1579593] Eur J Clin Invest. 2000 May;30(5):454-9 [10809906] FEBS Lett. 2000 Jul 14;477(1-2):1-7 [10899301] Biochem Biophys Res Commun. 2000 Aug 28;275(2):542-8 [10964700] Curr Opin Pulm Med. 2001 Jan;7(1):20-6 [11140402] Free Radic Biol Med. 2001 May 15;30(10):1145-53 [11369505] Free Radic Biol Med. 2001 Nov 15;31(10):1198-207 [11705698] Ann N Y Acad Sci. 2002 Apr;959:188-98 [11976196] Nat Rev Drug Discov. 2002 May;1(5):367-74 [12120412] Methods Enzymol. 2002;352:159-74 [12125344] Toxicology. 2002 Aug 15;177(2-3):285-97 [12135630] Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L777-84 [12225954] Nutrition. 2002 Oct;18(10):904-12 [12361786] Am J Respir Cell Mol Biol. 2003 Feb;28(2):199-207 [12540487] Am J Respir Crit Care Med. 2003 Jun 15;167(12):1600-19 [12796054] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Free Radic Biol Med. 2003 Aug 1;35(3):236-56 [12885586] Arch Biochem Biophys. 2004 Mar 1;423(1):162-9 [14871478] J Biol Chem. 2004 May 21;279(21):22152-7 [15044467] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2065-98 [15370472] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2239-66 [15370480] J Appl Physiol (1985). 2004 Nov;97(5):2006-13 [15298984] Histochem J. 1979 Jul;11(4):447-55 [91593] Methods Enzymol. 1994;234:316-20 [7808300] Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6264-8 [7603981] Respir Med. 2005 Feb;99(2):241-9 [15715193] Environ Sci Technol. 2005 Mar 1;39(5):1378-83 [15787380] Annu Rev Nutr. 2005;25:151-74 [16011463] J Comp Pathol. 2005 Aug-Oct;133(2-3):146-54 [16033696] IEEE Trans Nanobioscience. 2005 Jun;4(2):180-95 [16117026] Toxicol Appl Pharmacol. 2005 Sep 15;207(3):221-31 [16129115] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] J Occup Environ Med. 2005 Dec;47(12):1285-91 [16340710] Am J Respir Cell Mol Biol. 2006 Feb;34(2):226-32 [16224105] Mayo Clin Proc. 2006 Feb;81(2):205-12 [16471076] Histochem Cell Biol. 2006 Jun;125(6):661-9 [16307278] Toxicol Lett. 2006 Aug 1;165(1):88-100 [16527436] Anal Biochem. 1986 Aug 15;157(1):106-16 [3766953] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell shrinkage and monovalent cation fluxes: role in apoptosis. AN - 70602753; 17321483 AB - The loss of cell volume or cell shrinkage has been a morphological hallmark of the programmed cell death process known as apoptosis. This isotonic loss of cell volume has recently been term apoptotic volume decrease or AVD to distinguish it from inherent volume regulatory responses that occurs in cells under anisotonic conditions. Recent studies examining the intracellular signaling pathways that result in this unique cellular characteristic have determined that a fundamental movement of ions, particularly monovalent ions, underlie the AVD process and plays an important role on controlling the cell death process. An efflux of intracellular potassium was shown to be a critical aspect of the AVD process, as preventing this ion loss could protect cells from apoptosis. However, potassium plays a complex role as a loss of intracellular potassium has also been shown to be beneficial to the health of the cell. Additionally, the mechanisms that a cell employs to achieve this loss of intracellular potassium vary depending on the cell type and stimulus used to induce apoptosis, suggesting multiple ways exist to accomplish the same goal of AVD. Additionally, sodium and chloride have been shown to play a vital role during cell death in both the signaling and control of AVD in various apoptotic model systems. This review examines the relationship between this morphological change and intracellular monovalent ions during apoptosis. JF - Archives of biochemistry and biophysics AU - Bortner, Carl D AU - Cidlowski, John A AD - The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA. bortner@neihs.nih.gov Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 176 EP - 188 VL - 462 IS - 2 SN - 0003-9861, 0003-9861 KW - Apoptosis Regulatory Proteins KW - 0 KW - Cations KW - Ion Channels KW - Chlorine KW - 4R7X1O2820 KW - Sodium KW - 9NEZ333N27 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Oxidative Stress -- physiology KW - Models, Biological KW - Chlorine -- metabolism KW - Potassium -- metabolism KW - Cytoprotection -- physiology KW - Sodium -- metabolism KW - Ion Channel Gating -- physiology KW - Cell Size KW - Apoptosis -- physiology KW - Apoptosis Regulatory Proteins -- metabolism KW - Ion Channels -- physiology KW - Water-Electrolyte Balance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Cell+shrinkage+and+monovalent+cation+fluxes%3A+role+in+apoptosis.&rft.au=Bortner%2C+Carl+D%3BCidlowski%2C+John+A&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2007-06-15&rft.volume=462&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1996 Sep;271(3 Pt 1):C950-61 [8843726] Am J Physiol. 1997 Jan;272(1 Pt 1):G106-15 [9038883] Am J Physiol Cell Physiol. 2002 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30;275(26):19609-19 [10867019] Am J Physiol Cell Physiol. 2000 Jul;279(1):C158-65 [10898727] Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9487-92 [10900263] Biol Reprod. 2000 Sep;63(3):851-7 [10952931] Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1307-12 [9448327] J Neurochem. 1998 May;70(5):1925-34 [9572276] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6169-74 [9600936] J Immunol. 1998 Jun 1;160(11):5605-15 [9605166] EMBO J. 1998 Aug 17;17(16):4723-34 [9707431] Neurobiol Dis. 1998 Aug;5(2):81-8 [9746905] Am J Physiol Cell Physiol. 2006 Feb;290(2):C638-49 [16162654] Apoptosis. 2005 Dec;10(6):1317-31 [16215671] J Biol Chem. 2006 Jan 27;281(4):2232-41 [16299378] Mol Cell Biol. 2006 Feb;26(3):1038-50 [16428456] Neurosci Lett. 2006 May 1;398(1-2):22-7 [16434141] J Membr Biol. 2006 Jan;209(1):3-20 [16685597] J Membr Biol. 2006 Jan;209(1):21-9 [16685598] J Membr Biol. 2006 Jan;209(1):43-58 [16685600] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats AN - 20607357; 7435552 AB - The soluble metals of the pollutant, residual oil fly ash (ROFA), have been shown to alter pulmonary bacterial clearance in rats. The goal of this study was to determine the potential effects on both the innate and adaptive lung immune responses after bacterial infection in rats pre-exposed to the soluble metals in ROFA. Sprague-Dawley rats were intratracheally dosed (i.t.) at day 0 with ROFA (R-Total) (1.0 mg/100 g body weight), the soluble fraction of ROFA (R-Soluble), the soluble sample subject to a chelator (R-Chelex), or phosphate-buffered saline (Saline). On day 3, rats were administered an i.t. dose of 5x10 super(4)Listeria monocytogenes. On days 6, 8, and 10, bacterial pulmonary clearance was monitored and bronchoalveolar lavage (BAL) was performed on days 3 (pre-infection), 6, 8, and 10. A concentrated first fraction of lavage fluid was retained for analysis of lactate dehydrogenase and albumin to assess lung injury. BAL cell number, phenotype, and production of reactive oxygen (ROS) and nitrogen species (RNS) were assessed, and a variety of cytokines were measured in the BAL fluid. Rats pre-treated with R-Soluble showed elevated lung injury /cytotoxicity and increased cellular influx into the lungs. R-Soluble-treatment also altered ROS, RNS, and cytokine levels, and caused a degree of macrophage and T cell inhibition. These effects of R-Soluble result in increased pulmonary bacterial burden after infection. The results suggest that soluble metals in ROFA increase lung injury and inflammation, and alter both innate and adaptive pulmonary immune responses. JF - Toxicology and Applied Pharmacology AU - Roberts, J R AU - Young, SH AU - Castranova, V AU - Antonini, J M AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA, jur6@cdc.gov Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 306 EP - 319 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 221 IS - 3 SN - 0041-008X, 0041-008X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Bacteria KW - Metals KW - Injuries KW - Cell number KW - Fly ash KW - Chelating agents KW - Infection KW - Alveoli KW - L-Lactate dehydrogenase KW - Inflammation KW - Oil KW - Oxygen KW - Cytotoxicity KW - Bronchus KW - Pollutants KW - Body weight KW - Lung KW - Albumin KW - Lymphocytes T KW - Cytokines KW - Immune response KW - Nitrogen KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02350:Immunology KW - X 24360:Metals KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20607357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Soluble+metals+in+residual+oil+fly+ash+alter+innate+and+adaptive+pulmonary+immune+responses+to+bacterial+infection+in+rats&rft.au=Roberts%2C+J+R%3BYoung%2C+SH%3BCastranova%2C+V%3BAntonini%2C+J+M&rft.aulast=Roberts&rft.aufirst=J&rft.date=2007-06-15&rft.volume=221&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.03.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Metals; Cell number; Injuries; Fly ash; Infection; Chelating agents; Alveoli; Inflammation; L-Lactate dehydrogenase; Oil; Oxygen; Cytotoxicity; Body weight; Pollutants; Bronchus; Lung; Albumin; Lymphocytes T; Cytokines; Immune response; Nitrogen; Bacteria DO - http://dx.doi.org/10.1016/j.taap.2007.03.022 ER - TY - JOUR T1 - Backpropagation Artificial Neural Network Classifier to Detect Changes in Heart Sound due to Mitral Valve Regurgitation AN - 757014938; 17622023 AB - The phonocardiograph (PCG) can provide a non-invasive diagnostic ability to the clinicians and technicians to compare the heart acoustic signal obtained from normal and that of pathological heart (cardiac patient). This instrument was connected to the computer through the analog to digital (A/D) converter. The digital data stored for the normal and diseased (mitral valve regurgitation) heart in the computer were decomposed through the Coifman 4th order wavelet kernel. The decomposed phonocardiographic (PCG) data were tested by backpropagation artificial neural network (ANN). The network was containing 64 nodes in the input layer, weighted from the decomposed components of the PCG in the input layer, 16 nodes in the hidden layer and an output node. The ANN was found effective in differentiating the wavelet components of the PCG from mitral valve regurgitation confirmed person (93%) to normal subjects (98%) with an overall performance of 95.5%. This system can also be used to detect the defects in cardiac valves especially, and other several cardiac disorders in general.[PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Sinha, Rakesh Kumar AU - Aggarwal, Yogender AU - Das, Barda Nand Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 205 EP - 9 CY - New York PB - Springer Science & Business Media VL - 31 IS - 3 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Neural networks KW - Cardiology KW - Back propagation KW - Humans KW - Mitral Valve Insufficiency -- diagnosis KW - Neural Networks (Computer) KW - Signal Processing, Computer-Assisted -- instrumentation KW - Phonocardiography -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757014938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Backpropagation+Artificial+Neural+Network+Classifier+to+Detect+Changes+in+Heart+Sound+due+to+Mitral+Valve+Regurgitation&rft.au=Sinha%2C+Rakesh+Kumar%3BAggarwal%2C+Yogender%3BDas%2C+Barda+Nand&rft.aulast=Sinha&rft.aufirst=Rakesh&rft.date=2007-06-01&rft.volume=31&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9056-1 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2007 N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-007-9056-1 ER - TY - JOUR T1 - Synthesis and photoirradiation of isomeric ethylchrysenes by UVA light leading to lipid peroxidation. AN - 70681366; 17617678 AB - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants. We have recently demonstrated that photoirradiation of PAHs leads to cytotoxicity, DNA damage, and induction of lipid peroxidation. In this paper we report the synthesis of all the six isomeric ethylchrysenes and the study of light-induced lipid peroxidation by these ethylchrysenes. 5-Ethylchrysene was synthesized by reaction of 5-keto-5,6,6a,7,8,9,10,10a-octahydrochrysene with CH3CH2MgBr followed by dehydration catalyzed by p-toluenesulfonic acid and dehydrogenation with DDQ in benzene. 1- and 4-Ethylchrysenes were similarly prepared by reaction of 1-keto-1,2,3,4,5,6-hexahydrochrysene and 4-keto-1,2,3,4-tetrahydrochrysenes, respectively with CH3CH2MgBr followed by dehydration and dehydrogenation. Direct acetylation of chrysene followed by Wolff-Kishner or Clemmensen reduction resulted in the formation of 2-, 3-, and 6-ethylchrysenes in 4%, 16%, and 43% yields, respectively. Photoirradiation of these compounds with 7 and 21 J/cm2 UVA light in the presence of methyl linoleate all resulted in lipid peroxidation. For comparison, photoirradiation of 4-methylchrysene and 5-methylchrysene was similarly conducted. For irradiation at a UVA light dose of 21 J/cm2, the level of induced lipid peroxidation is in the order 4-methylchrysene = 5-methylchrysene = 5-ethylchrysene = 4-ethylchrysene = chrysene > 1-ethylchrysene = 2-ethylchrysene > 3-ethylchrysene > 6-ethylchrysene. Compared with chrysene, these results indicate that the ethyl group at C4 or C5 position either slightly enhances or has no effect on the light-induced lipid peroxidation, while at C1-, C2-, C3-, or C6 position reduces light-induced lipid peroxidation. JF - International journal of environmental research and public health AU - Chen, Hui-Chan AU - Xia, Qingsu AU - Cherng, Shu-Hui AU - Chen, Shoujun AU - Lai, Ching-Cheng AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 145 EP - 152 VL - 4 IS - 2 SN - 1661-7827, 1661-7827 KW - Chrysenes KW - 0 KW - Lipid Peroxides KW - Polycyclic Aromatic Hydrocarbons KW - Reactive Oxygen Species KW - ethylchrysene KW - hexahydrochrysene KW - octahydrochrysene KW - chrysene KW - 084HCM49PT KW - Index Medicus KW - DNA Damage KW - Humans KW - Phototherapy KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Chrysenes -- toxicity KW - Ultraviolet Rays -- adverse effects KW - Lipid Peroxidation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70681366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Synthesis+and+photoirradiation+of+isomeric+ethylchrysenes+by+UVA+light+leading+to+lipid+peroxidation.&rft.au=Chen%2C+Hui-Chan%3BXia%2C+Qingsu%3BCherng%2C+Shu-Hui%3BChen%2C+Shoujun%3BLai%2C+Ching-Cheng%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Chen&rft.aufirst=Hui-Chan&rft.date=2007-06-01&rft.volume=4&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=16617827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-08 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477] Int J Environ Res Public Health. 2006 Dec;3(4):348-54 [17159277] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):149-83 [12515673] Methods Enzymol. 1984;105:539-50 [6328205] Anal Biochem. 1987 Jun;163(2):343-9 [3116881] Chem Res Toxicol. 1992 Mar-Apr;5(2):220-6 [1643251] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7491-5 [8052609] Carcinogenesis. 1995 Aug;16(8):1941-5 [7634425] Ecotoxicol Environ Saf. 1996 Feb;33(1):1-24 [8744919] J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511] Solid State Nucl Magn Reson. 1998 Oct;12(4):251-6 [9800270] Chem Res Toxicol. 1999 Jan;12(1):1-18 [9894013] Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116] Toxicol Ind Health. 2006 May;22(4):147-56 [16786836] Eye (Lond). 2001 Jun;15(Pt 3):371-5 [11450760] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medical fitness evaluation for respirator users: results of a national survey of private sector employers. AN - 70610984; 17563613 AB - To provide information on medical evaluation procedures for respirator use in private sector establishments. In 2001, data on respirator use and practices were collected in a survey of private sector establishments. Of establishments where respirators were required, 46% did not evaluate employees' medical fitness. Evaluations for fitness increased with establishment size, ranging from 35% in small establishments (1-10 workers) to 95% in large establishments (>or=1000 workers). Questionnaire with a follow-up examination, as needed, was the most common method of evaluating medical fitness (48%). Results suggest that about half of all private sector establishments where respirators are required do not comply with Occupational Safety and Health Administration requirements for medical fitness evaluations. Improved awareness among employers and workers and identification of methods to increase medical evaluation practices, especially among smaller establishments, is needed. JF - Journal of occupational and environmental medicine AU - Syamlal, Girija AU - Doney, Brent AU - Bang, Ki Moon AU - Greskevitch, Mark AU - Groce, Dennis AU - Ganocy, Stephen AU - Hoffman, William AD - National Institute for Occupational Safety and Health (NIOSH), Division of Respiratory Disease Studies, Morgantown, WV 26505, USA. gsyamlal@cdc.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 691 EP - 699 VL - 49 IS - 6 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - United States KW - Humans KW - Health Status KW - Surveys and Questionnaires KW - Equipment Safety -- utilization KW - United States Occupational Safety and Health Administration -- standards KW - Respiratory Protective Devices -- utilization KW - Private Sector KW - Occupational Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70610984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Medical+fitness+evaluation+for+respirator+users%3A+results+of+a+national+survey+of+private+sector+employers.&rft.au=Syamlal%2C+Girija%3BDoney%2C+Brent%3BBang%2C+Ki+Moon%3BGreskevitch%2C+Mark%3BGroce%2C+Dennis%3BGanocy%2C+Stephen%3BHoffman%2C+William&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2007-06-01&rft.volume=49&rft.issue=6&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of military and civilian reporting rates for smallpox vaccine adverse events. AN - 70598745; 17154344 AB - US smallpox vaccination (SMA) started most recently in December 2002. Military and civilian personnel report adverse events (AEs) to the Vaccine Adverse Event Reporting System (VAERS), a surveillance system that relies on spontaneous reports. Although reported rates of probable myo/pericarditis after SMA in the literature are similar between military personnel and civilian healthcare workers, some civilian AE reporting rates after SMA appeared higher than those in the military. Determine if SMA-associated reporting rates are different in civilians than in the military, considering age, sex, seriousness, and expectedness of the AE, as well as self-reporting. Numerators were SMA reports in VAERS from 12/12/02 to 3/1/04. Limitations of VAERS include underreporting and lack of diagnostic confirmation. Denominators were number of military and civilian vaccinees. Reporting rates stratified by age and sex of serious and non-serious AEs were significantly higher in civilian than military personnel ages <55 years (rate ratios 4-27). These rate ratios decreased with increasing age. Reporting rates in VAERS differed significantly and substantially in civilians compared to military personnel <55 years of age. Differences in stimulated passive surveillance systems, and AE reporting practices, including the 'threshold' for reporting most likely explain these findings. These results suggest that in the case of smallpox vaccine AEs, there may be systematic differences in reporting completeness between the civilian and military sectors, and that passive surveillance data should be interpreted with caution. Copyright (c) 2006 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - McMahon, A W AU - Zinderman, C AU - Ball, R AU - Gupta, G AU - Braun, M M AD - Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, MD, USA. ann.mcmahon@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 597 EP - 604 VL - 16 IS - 6 SN - 1053-8569, 1053-8569 KW - Smallpox Vaccine KW - 0 KW - Index Medicus KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Vaccination KW - Male KW - Female KW - Military Personnel KW - Smallpox Vaccine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70598745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Comparison+of+military+and+civilian+reporting+rates+for+smallpox+vaccine+adverse+events.&rft.au=McMahon%2C+A+W%3BZinderman%2C+C%3BBall%2C+R%3BGupta%2C+G%3BBraun%2C+M+M&rft.aulast=McMahon&rft.aufirst=A&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. AN - 70575050; 17543868 AB - The yeast Vps27/Hse1 complex and the homologous mammalian Hrs/STAM complex deliver ubiquitinated transmembrane proteins to the ESCRT endosomal-sorting pathway. The Vps27/Hse1 complex directly binds to ubiquitinated transmembrane proteins and recruits both ubiquitin ligases and deubiquitinating enzymes. We have solved the crystal structure of the core responsible for the assembly of the Vps27/Hse1 complex at 3.0 A resolution. The structure consists of two intertwined GAT domains, each consisting of two helices from one subunit and one from the other. The two GAT domains are connected by an antiparallel coiled coil, forming a 90 A-long barbell-like structure. This structure places the domains of Vps27 and Hse1 that recruit ubiquitinated cargo and deubiquitinating enzymes close to each other. Coarse-grained Monte Carlo simulations of the Vps27/Hse1 complex on a membrane show how the complex binds cooperatively to lipids and ubiquitinated membrane proteins and acts as a scaffold for ubiquitination reactions. JF - Developmental cell AU - Prag, Gali AU - Watson, Hadiya AU - Kim, Young C AU - Beach, Bridgette M AU - Ghirlando, Rodolfo AU - Hummer, Gerhard AU - Bonifacino, Juan S AU - Hurley, James H AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 973 EP - 986 VL - 12 IS - 6 SN - 1534-5807, 1534-5807 KW - Endosomal Sorting Complexes Required for Transport KW - 0 KW - Hse1 protein, S cerevisiae KW - Receptors, Cytoplasmic and Nuclear KW - Saccharomyces cerevisiae Proteins KW - Ubiquitin KW - VPS27 protein, S cerevisiae KW - Vesicular Transport Proteins KW - Index Medicus KW - Models, Molecular KW - Immunoprecipitation KW - Amino Acid Sequence KW - Protein Binding KW - Mutagenesis, Site-Directed KW - Ubiquitin -- metabolism KW - Chromatography, Gel KW - Molecular Sequence Data KW - Mutation -- genetics KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Protein Transport KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Vesicular Transport Proteins -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- chemistry KW - Saccharomyces cerevisiae -- chemistry KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Vesicular Transport Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Vesicular Transport Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+cell&rft.atitle=The+Vps27%2FHse1+complex+is+a+GAT+domain-based+scaffold+for+ubiquitin-dependent+sorting.&rft.au=Prag%2C+Gali%3BWatson%2C+Hadiya%3BKim%2C+Young+C%3BBeach%2C+Bridgette+M%3BGhirlando%2C+Rodolfo%3BHummer%2C+Gerhard%3BBonifacino%2C+Juan+S%3BHurley%2C+James+H&rft.aulast=Prag&rft.aufirst=Gali&rft.date=2007-06-01&rft.volume=12&rft.issue=6&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Developmental+cell&rft.issn=15345807&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Expr Purif. 2001 Feb;21(1):224-34 [11162410] Nat Rev Mol Cell Biol. 2001 Mar;2(3):169-78 [11265246] Nat Rev Mol Cell Biol. 2001 Mar;2(3):195-201 [11265249] J Cell Sci. 2001 Jun;114(Pt 12):2255-63 [11493665] Cell. 2001 Jul 27;106(2):145-55 [11511343] Traffic. 2001 Sep;2(9):612-21 [11555415] J Cell Sci. 2001 Sep;114(Pt 17):3075-81 [11590234] Mol Cell Biol. 2001 Dec;21(23):7981-94 [11689690] Annu Rev Biochem. 2001;70:503-33 [11395416] Cell. 2002 Jan 25;108(2):261-9 [11832215] Nat Cell Biol. 2002 May;4(5):389-93 [11988742] Nat Cell Biol. 2002 May;4(5):394-8 [11988743] Protein Sci. 2002 Jun;11(6):1285-99 [12021428] Nat Cell Biol. 2002 Jul;4(7):534-9 [12055639] J Biol Chem. 2002 Jul 19;277(29):26379-88 [12006563] Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 [12461556] Dev Cell. 2003 Mar;4(3):321-32 [12636914] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4451-6 [12668765] J Mol Biol. 2003 May 2;328(3):721-36 [12706728] Nat Struct Biol. 2003 May;10(5):386-93 [12679809] Biochemistry. 2003 Jun 3;42(21):6392-9 [12767220] Nucleic Acids Res. 2003 Jul 1;31(13):3300-4 [12824312] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31 [12802020] J Biol Chem. 2003 Aug 1;278(31):28976-84 [12750381] Biochem J. 2006 Nov 1;399(3):361-72 [17034365] Mol Biol Cell. 2007 Jan;18(1):324-35 [17079730] Curr Opin Cell Biol. 2003 Aug;15(4):446-55 [12892785] Anal Biochem. 2003 Sep 1;320(1):104-24 [12895474] J Cell Biol. 2003 Aug 4;162(3):413-23 [12900393] EMBO J. 2003 Sep 15;22(18):4597-606 [12970172] J Cell Biol. 2003 Oct 27;163(2):237-43 [14581452] Trends Biochem Sci. 2003 Nov;28(11):598-603 [14607090] J Biol Chem. 2003 Nov 28;278(48):48162-8 [13129930] J Biol Chem. 2003 Dec 26;278(52):52865-72 [14563850] Nat Rev Mol Cell Biol. 2004 Jan;5(1):23-32 [14708007] J Biol Chem. 2004 Feb 20;279(8):7105-11 [14660606] Nat Cell Biol. 2004 Mar;6(3):244-51 [15039775] Nat Cell Biol. 2004 Mar;6(3):252-9 [15039776] Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23 [15071556] Traffic. 2004 Mar;5(3):194-210 [15086794] J Biochem. 2004 Mar;135(3):385-96 [15113837] J Biol Chem. 2004 Jun 4;279(23):24435-43 [15047686] J Biol Chem. 2004 Jul 23;279(30):31409-18 [15143060] Annu Rev Cell Dev Biol. 2004;20:395-425 [15473846] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] J Cell Biol. 1995 Nov;131(3):603-17 [7593183] Trends Biochem Sci. 1995 Nov;20(11):478-80 [8578593] J Mol Biol. 1996 Mar 1;256(3):623-44 [8604144] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Cell. 1999 May 28;97(5):657-66 [10367894] Virus Res. 2004 Dec;106(2):87-102 [15567490] Traffic. 2005 Jan;6(1):2-9 [15569240] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Biochem. 2005 Jan;137(1):1-8 [15713877] Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2334-9 [15701688] J Biol Chem. 2005 Mar 11;280(10):9258-64 [15611048] Genes Cells. 2005 Jul;10(7):639-54 [15966896] Biochim Biophys Acta. 2005 Jul 10;1744(3):438-54 [15913810] Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21 [16064137] FEBS Lett. 2005 Oct 10;579(24):5385-91 [16199040] Curr Biol. 2006 Jan 24;16(2):160-5 [16431367] Nat Struct Mol Biol. 2006 Mar;13(3):272-7 [16462748] Cell. 2006 Mar 24;124(6):1133-6 [16564007] Structure. 2006 Apr;14(4):661-71 [16615908] Annu Rev Biophys Biomol Struct. 2006;35:277-98 [16689637] J Cell Sci. 2006 Jun 15;119(Pt 12):2414-24 [16720641] Trends Cell Biol. 2006 Jun;16(6):317-26 [16716591] Cell. 2000 Feb 18;100(4):447-56 [10693761] Nat Cell Biol. 2000 Aug;2(8):E153-7 [10934491] Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):965-72 [10944333] Nat Med. 2000 Oct;6(10):1073-81 [11017125] J Biol Chem. 2000 Dec 1;275(48):37481-7 [10982817] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A probabilistic framework for non-cancer risk assessment. AN - 70571410; 17166641 AB - Risk assessment involves an analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level or to estimate a low-dose risk. Acceptable levels of human exposure for non-cancer effects generally are derived by dividing an experimental no-observed-adverse-effect-level or a lower confidence limit benchmark dose by a product of several uncertainty factors. This paper presents a hierarchical modeling framework for a probabilistic approach to non-cancer risk assessment. The hierarchical model integrates the distributions of uncertainty factors and the distribution of the actual exposure level to construct the dose-response model for the proportion of population at risk and the dose-response model for the expected proportion of population at risk for a given exposure distribution. The proposed approach is based on the use of the BMDL (lower confidence limit on the benchmark dose) as a POD (point of departure) for risk assessment of non-cancer effects. JF - Regulatory toxicology and pharmacology : RTP AU - Chen, James J AU - Moon, Hojin AU - Kodell, Ralph L AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 45 EP - 50 VL - 48 IS - 1 SN - 0273-2300, 0273-2300 KW - Index Medicus KW - Probability KW - Animals KW - No-Observed-Adverse-Effect Level KW - Environmental Health KW - Dose-Response Relationship, Drug KW - Humans KW - Likelihood Functions KW - Risk Assessment KW - Models, Theoretical KW - Models, Statistical KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70571410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+probabilistic+framework+for+non-cancer+risk+assessment.&rft.au=Chen%2C+James+J%3BMoon%2C+Hojin%3BKodell%2C+Ralph+L&rft.aulast=Chen&rft.aufirst=James&rft.date=2007-06-01&rft.volume=48&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions. AN - 70563668; 17331631 AB - Multiple types of outcomes are sometimes measured on each animal in toxicology dose-response experiments. The potential false-positive rate from statistical tests on each endpoint may be inflated. We introduce a method of deriving a composite score that combines information from discrete and continuous outcomes through the use of desirability functions. These functions transform observed responses of any type to a 0-to-1 unitless scale. The geometric mean is used to combine the scores and then a statistical model is fit to the dose-response curve of the overall score. The overall desirability score is more sensitive to toxicity evident in only a few endpoints than other composite scores that are based on sums of components. We analyze the overall score using a nonlinear exponential model with a threshold parameter. In this example, the threshold parameter was statistically significant and its estimate was less than the lowest dose. Compared to the vehicle control, the lower overall scores at this dose group were due to lower levels of brain and blood cholinesterase (90% and 82% of control, respectively) whereas other endpoints were not altered, thus demonstrating the sensitivity of the desirability function to detect low levels of toxicity in a small number of outcomes. JF - Regulatory toxicology and pharmacology : RTP AU - Coffey, Todd AU - Gennings, Chris AU - Moser, Virginia C AD - Department of Biostatistics, Virginia Commonwealth University, PO Box 980032, Richmond, VA 23298, USA. jchen@nctr.fda.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 51 EP - 58 VL - 48 IS - 1 SN - 0273-2300, 0273-2300 KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Sensitivity and Specificity KW - Rats KW - Animals KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Surveys and Questionnaires KW - Male KW - Toxicity Tests -- methods KW - Models, Statistical KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70563668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+simultaneous+analysis+of+discrete+and+continuous+outcomes+in+a+dose-response+study%3A+using+desirability+functions.&rft.au=Coffey%2C+Todd%3BGennings%2C+Chris%3BMoser%2C+Virginia+C&rft.aulast=Coffey&rft.aufirst=Todd&rft.date=2007-06-01&rft.volume=48&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The 2006 Report of the Surgeon General: the health consequences of involuntary exposure to tobacco smoke. AN - 70549024; 17533072 JF - American journal of preventive medicine AU - Moritsugu, Kenneth P AD - Office of the Acting U.S. Surgeon General, U.S. Public Health Service, Washington DC, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 542 EP - 543 VL - 32 IS - 6 SN - 0749-3797, 0749-3797 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - United States KW - Inhalation Exposure KW - Humans KW - Public Health KW - Tobacco Smoke Pollution -- adverse effects KW - Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70549024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=The+2006+Report+of+the+Surgeon+General%3A+the+health+consequences+of+involuntary+exposure+to+tobacco+smoke.&rft.au=Moritsugu%2C+Kenneth+P&rft.aulast=Moritsugu&rft.aufirst=Kenneth&rft.date=2007-06-01&rft.volume=32&rft.issue=6&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-27 N1 - Date created - 2007-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells. AN - 70547093; 17455326 AB - The molecular mechanisms involved in N-methyl-D-aspartate (NMDA)-induced cell death and Delta9-tetrahydrocannabinol (THC)-induced neuroprotection were investigated in vitro with an AF5 neural progenitor cell line model. By microarray analysis, Ywhah, CK1, Hsp60, Pdcd 4, and Pdcd 7 were identified as being strongly regulated by both NMDA toxicity and THC neuroprotection. The 14-3-3 eta (14-3-3eta; gene symbol Ywhah) and 14-3-3 zeta (14-3-3zeta; gene symbol Ywhaz) transcripts were deceased by NMDA treatment and increased by THC treatment prior to NMDA, as measured by cDNA microarray analysis and quantitative real-time RT-PCR. Other 14-3-3 isoforms were unchanged. Whereas up-regulation of 14-3-3zeta expression was observed 30 min after treatment with THC plus NMDA, down-regulation by NMDA alone was not seen until 16 hr after treatment. By Western blotting, THC increased 14-3-3 protein only in cells that were also treated with NMDA. Overexpression of 14-3-3eta or 14-3-3zeta by transient plasmid transfection increased 14-3-3 protein levels and decreased NMDA-induced cell death. These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress. Copyright (c) 2007 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Chen, Jia AU - Lee, Chun-Ting AU - Errico, Stacie L AU - Becker, Kevin G AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. jichen@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1724 EP - 1733 VL - 85 IS - 8 SN - 0360-4012, 0360-4012 KW - 14-3-3 Proteins KW - 0 KW - Neuroprotective Agents KW - N-Methylaspartate KW - 6384-92-5 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Transfection KW - Plasmids KW - Mesencephalon -- cytology KW - Cell Line KW - N-Methylaspartate -- physiology KW - Dronabinol -- pharmacology KW - 14-3-3 Proteins -- biosynthesis KW - N-Methylaspartate -- toxicity KW - N-Methylaspartate -- antagonists & inhibitors KW - 14-3-3 Proteins -- genetics KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70547093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Increases+in+expression+of+14-3-3+eta+and+14-3-3+zeta+transcripts+during+neuroprotection+induced+by+delta9-tetrahydrocannabinol+in+AF5+cells.&rft.au=Chen%2C+Jia%3BLee%2C+Chun-Ting%3BErrico%2C+Stacie+L%3BBecker%2C+Kevin+G%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2007-06-01&rft.volume=85&rft.issue=8&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Feb 1;19(3):349-58 [10654934] Neurosci Res. 2006 Sep;56(1):61-72 [16797759] Mol Cell. 2000 Jul;6(1):41-51 [10949026] Physiol Genomics. 2000 Sep 8;3(3):175-85 [11015613] Nat Genet. 2001 May;28(1):17-8 [11326268] Brain Res Bull. 2001 Jul 15;55(5):641-50 [11576761] Bioessays. 2001 Oct;23(10):936-46 [11598960] J Biol Chem. 2001 Nov 30;276(48):45193-200 [11577088] Exp Neurol. 2002 Jun;175(2):318-37 [12061863] Biochem Soc Trans. 2002 Aug;30(4):360-5 [12196095] Chem Phys Lipids. 2002 Dec 31;121(1-2):257-66 [12505705] Mol Psychiatry. 2003 Feb;8(2):156-66 [12610648] Mol Cell Biol. 2003 Apr;23(7):2362-78 [12640121] J Mol Diagn. 2003 May;5(2):73-81 [12707371] Curr Mol Med. 2003 Aug;3(5):437-46 [12942997] Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):153-62 [14741760] Exp Cell Res. 2004 Apr 1;294(2):581-91 [15023544] FEBS Lett. 1993 Oct 4;331(3):296-303 [8375512] Brain Res Mol Brain Res. 1994 Aug;25(1-2):113-21 [7984035] Mol Neurobiol. 1995 Aug-Dec;11(1-3):223-30 [8561965] Genomics. 1996 Aug 15;36(1):63-9 [8812417] Science. 1997 Jan 3;275(5296):90-4 [8974401] J Biol Chem. 1997 May 23;272(21):13717-24 [9153224] Cell Tissue Res. 1998 Feb;291(2):175-89 [9426306] Cell. 1999 Mar 19;96(6):857-68 [10102273] Am J Med Genet. 1999 Apr 16;88(2):164-7 [10206237] J Pharmacol Exp Ther. 1999 Jun;289(3):1559-63 [10336553] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8511-5 [10411906] J Cereb Blood Flow Metab. 2005 Mar;25(3):338-47 [15660102] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Neurosci Lett. 2005 Dec 2;389(2):99-103 [16098661] Handb Exp Pharmacol. 2006;(172):171-98 [16610360] Acta Neuropathol. 2006 May;111(5):413-21 [16557393] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9127-32 [10922068] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient handling tasks with high risk for musculoskeletal disorders in critical care. AN - 70525944; 17512469 AB - Critical care nurses are at high risk for development of work-related musculoskeletal disorders (WMSDs). Many patient handling tasks in critical care require physical demands that may result in excessive internal forces, increasing the risk for WMSDs. There are solutions for performing these tasks safely, using technology. This article describes risk factors associated with high-risk patient handling tasks and presents solutions for reducing risk for WMSDs. Studies show that implementing a safe patient handling and movement program that incorporates new technology can pay for itself in a short period of time and provide long-term benefit for health care facilities and nursing staff. JF - Critical care nursing clinics of North America AU - Waters, Thomas R AU - Nelson, Audrey AU - Proctor, Caren AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway (MS-C24), Cincinnati, OH 45226, USA. trw1@cdc.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 131 EP - 143 VL - 19 IS - 2 SN - 0899-5885, 0899-5885 KW - Nursing KW - Occupational Health KW - Human Engineering KW - Bed Rest -- nursing KW - Humans KW - Algorithms KW - Weight-Bearing KW - Risk Assessment KW - Body Weight KW - Biomechanical Phenomena KW - Risk Factors KW - Decision Trees KW - Transportation of Patients -- organization & administration KW - Nurse's Role KW - Workload -- statistics & numerical data KW - United States -- epidemiology KW - Safety Management -- organization & administration KW - Nursing Staff, Hospital -- organization & administration KW - Musculoskeletal Diseases -- etiology KW - Musculoskeletal Diseases -- prevention & control KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Lifting -- adverse effects KW - Musculoskeletal Diseases -- epidemiology KW - Critical Care -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70525944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+nursing+clinics+of+North+America&rft.atitle=Patient+handling+tasks+with+high+risk+for+musculoskeletal+disorders+in+critical+care.&rft.au=Waters%2C+Thomas+R%3BNelson%2C+Audrey%3BProctor%2C+Caren&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2007-06-01&rft.volume=19&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Critical+care+nursing+clinics+of+North+America&rft.issn=08995885&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-20 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine administration causes death of dopaminergic neurons in the mouse olfactory bulb. AN - 70516689; 17161385 AB - Methamphetamine (METH) is an addictive drug that can cause neurological and psychiatric disorders. In the rodent brain, toxic doses of METH cause damage of dopaminergic terminals and apoptosis of nondopaminergic neurons. The olfactory bulb (OB) is a brain region that is rich with dopaminergic neurons and terminals. Rats were given a single injection of METH (40 mg/kg) and sacrificed at various time points afterward. The toxic effects of this injection on the OB were assessed by measuring monoamine levels, tyrosine hydroxylase (TH) immunocytochemistry, terminal deoxynucleotidyl transferase-mediated deoxyribonucleotide triphosphate (dNTP) nick end labeling (TUNEL) histochemistry, and caspase-3 immunochemistry. Methamphetamine administration caused marked decreases in dopamine (DA) levels and TH-like immunostaining in the mouse OB. The drug also caused increases in TUNEL-labeled OB neurons, some of which were also positive for TH expression. Moreover, there was METH-induced expression of activated caspase-3 in TH-positive cells. Finally, the METH injection was associated with increased expression of the proapoptotic proteins, Bax and Bid, but with decreased expression of the antideath protein, Bcl2. These observations show, for the first time, that METH can cause loss of OB DA terminals and death of DA neurons, in part, via mechanisms that are akin to an apoptotic process. JF - Biological psychiatry AU - Deng, Xiaolin AU - Ladenheim, Bruce AU - Jayanthi, Subramaniam AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA. Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 1235 EP - 1243 VL - 61 IS - 11 SN - 0006-3223, 0006-3223 KW - Central Nervous System Stimulants KW - 0 KW - RTI 121 KW - 146145-21-3 KW - Methamphetamine KW - 44RAL3456C KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Tyrosine 3-Monooxygenase -- metabolism KW - Mice, Inbred ICR KW - Cerebral Cortex -- drug effects KW - Mice KW - Autoradiography KW - Cell Death -- drug effects KW - Chromatography, High Pressure Liquid KW - In Situ Nick-End Labeling KW - Presynaptic Terminals -- drug effects KW - Blotting, Western KW - Cocaine -- analogs & derivatives KW - Neostriatum -- drug effects KW - Apoptosis -- drug effects KW - Neostriatum -- cytology KW - Immunohistochemistry KW - Male KW - Olfactory Bulb -- physiology KW - Central Nervous System Stimulants -- toxicity KW - Neurons -- drug effects KW - Dopamine -- physiology KW - Olfactory Bulb -- cytology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70516689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Methamphetamine+administration+causes+death+of+dopaminergic+neurons+in+the+mouse+olfactory+bulb.&rft.au=Deng%2C+Xiaolin%3BLadenheim%2C+Bruce%3BJayanthi%2C+Subramaniam%3BCadet%2C+Jean+Lud&rft.aulast=Deng&rft.aufirst=Xiaolin&rft.date=2007-06-01&rft.volume=61&rft.issue=11&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-10 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. AN - 70417341; 17343880 AB - Micro RNAs (miRNAs) are small non-coding RNA molecules that function as negative regulators of gene expression. They play a crucial role in the regulation of genes involved in the control of development, cell proliferation, apoptosis, and stress response. Although miRNA levels are substantially altered in tumors, their role in carcinogenesis, specifically at the early pre-cancerous stages, has not been established. Here we report that exposure of Fisher 344 rats to tamoxifen, a potent hepatocarcinogen in rats, for 24 weeks leads to substantial changes in the expression of miRNA genes in the liver. We noted a significant up-regulation of known oncogenic miRNAs, such as the 17-92 cluster, miR-106a, and miR-34. Furthermore, we confirmed the corresponding changes in the expression of proteins targeted by these miRNAs, which include important cell cycle regulators, chromatin modifiers, and expression regulators implicated in carcinogenesis. All these miRNA changes correspond to previously reported alterations in full-fledged tumors, including hepatocellular carcinomas. Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state. JF - Mutation research AU - Pogribny, Igor P AU - Tryndyak, Volodymyr P AU - Boyko, Alex AU - Rodriguez-Juarez, Rocio AU - Beland, Frederick A AU - Kovalchuk, Olga AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. igor.pogribny@fda.hhs.gov Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 30 EP - 37 VL - 619 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Carcinogens KW - MicroRNAs KW - Tamoxifen KW - 094ZI81Y45 KW - Index Medicus KW - Liver Neoplasms, Experimental -- genetics KW - Animals KW - Carcinogens -- administration & dosage KW - Oligonucleotide Array Sequence Analysis KW - Carcinogens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - DNA Replication -- drug effects KW - Antineoplastic Agents, Hormonal -- toxicity KW - Rats KW - Gene Expression Profiling KW - Rats, Inbred F344 KW - Apoptosis -- genetics KW - DNA Replication -- genetics KW - Antineoplastic Agents, Hormonal -- administration & dosage KW - Apoptosis -- drug effects KW - Cell Cycle -- genetics KW - Cell Cycle -- drug effects KW - Female KW - Tamoxifen -- toxicity KW - Liver -- cytology KW - MicroRNAs -- metabolism KW - MicroRNAs -- genetics KW - Liver -- drug effects KW - Liver -- metabolism KW - Tamoxifen -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70417341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Induction+of+microRNAome+deregulation+in+rat+liver+by+long-term+tamoxifen+exposure.&rft.au=Pogribny%2C+Igor+P%3BTryndyak%2C+Volodymyr+P%3BBoyko%2C+Alex%3BRodriguez-Juarez%2C+Rocio%3BBeland%2C+Frederick+A%3BKovalchuk%2C+Olga&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2007-06-01&rft.volume=619&rft.issue=1-2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-21 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6. AN - 70413252; 17374475 AB - We previously demonstrated that high doses of environmental cigarette smoke (ECS) induce alopecia in mice. This effect was prevented by the oral administration of N-acetylcysteine (NAC), an analogue and precursor of L-cysteine and reduced glutathione. The present study aimed at assessing whether L-cystine, the oxidized form of L-cysteine, which is a key hair component, may behave like NAC in inhibiting ECS-induced alopecia and modulating the mechanisms responsible for this condition. C57BL/6 mice were exposed whole-body to ECS in a smoking machine. Groups of mice received in the diet, at three dose levels, a mixture of L-cystine with vitamin B6, which plays a role in L-cystine incorporation in hair cells. Occurrence of alopecia areas and apoptosis of hair bulb cells were evaluated for up to 6 months of exposure, and the time course induction of micronucleated erythrocytes in peripheral blood was investigated. The frequency of micronucleated erythrocytes was increased by ECS, irrespective of treatment with L-cystine/vitamin B6. ECS-induced alopecia and apoptosis of hair bulb cells in all exposed mice. L-Cystine/vitamin B6 inhibited alopecia in a dose-dependent fashion. High-dose ECS induces apoptosis-related alopecia in mice, and oral administration of L-cystine/vitamin B6 is an effective preventive treatment. JF - Journal of dermatological science AU - D'Agostini, Francesco AU - Fiallo, Paolo AU - Pennisi, Tanya M AU - De Flora, Silvio AD - Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy. fda@unige.it Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 189 EP - 198 VL - 46 IS - 3 SN - 0923-1811, 0923-1811 KW - Tobacco Smoke Pollution KW - 0 KW - Cystine KW - 48TCX9A1VT KW - Vitamin B 6 KW - 8059-24-3 KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Body Weight KW - Administration, Oral KW - Animals KW - Hair Follicle -- pathology KW - Apoptosis KW - Hair Follicle -- metabolism KW - Dose-Response Relationship, Drug KW - Acetylcysteine -- administration & dosage KW - Mice, Inbred C57BL KW - Mice KW - Acetylcysteine -- pharmacology KW - Female KW - Cystine -- metabolism KW - Alopecia -- pathology KW - Cystine -- pharmacology KW - Alopecia -- etiology KW - Vitamin B 6 -- administration & dosage KW - Tobacco Smoke Pollution -- adverse effects KW - Chemoprevention -- methods KW - Cystine -- administration & dosage KW - Alopecia -- prevention & control KW - Vitamin B 6 -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70413252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dermatological+science&rft.atitle=Chemoprevention+of+smoke-induced+alopecia+in+mice+by+oral+administration+of+L-cystine+and+vitamin+B6.&rft.au=D%27Agostini%2C+Francesco%3BFiallo%2C+Paolo%3BPennisi%2C+Tanya+M%3BDe+Flora%2C+Silvio&rft.aulast=D%27Agostini&rft.aufirst=Francesco&rft.date=2007-06-01&rft.volume=46&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+dermatological+science&rft.issn=09231811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Noninvasive assessment of cytokines in occupational respiratory diseases. AN - 70146158; 19075972 AB - A major goal in studying occupational respiratory diseases is to show relationships between occupational exposures and health outcomes. Due to the nature of these diseases, accurate, practical, and objective measurement techniques are needed in field investigations. Pulmonary function tests, such as spirometry, are important objective health outcome measures. However, they reflect the functional changes of the lung, often in relatively late stages, which may be irreversible. Direct monitoring of airways inflammations, in response to occupational exposures, are receiving an increasing attention since they may pick up inflammatory changes before the injury becomes irreversible. Invasive approaches such as bronchoalveolar lavage and bronchial biopsies have been used to assess airways inflammation: but these methods are not practical for use in occupational field investigations. Thus, much work has focused on the development of noninvasive methods for monitoring inflammation in occupational respiratory diseases. The three recent most commonly used noninvasive techniques in occupational respiratory diseases investigations are induced sputum, exhaled breath condensate, and nasal lavage. In this review, we discuss the practical application of these techniques, patents and cytokines measured with them. Since variation of cytokine genes contribute to the inflammatory processes, we briefly discuss the genetic polymorphisms on the expression of occupational respiratory diseases. Details of genetic polymorphism were beyond the focus of this review. Our primary focus was cytokines measured with these three noninvasive techniques in occupational respiratory investigations. JF - Recent patents on inflammation & allergy drug discovery AU - Akpinar-Elci, Muge AU - Yucesoy, Berran AU - Elci, Omur Cinar AU - Weissman, David N AD - CDC/NIOSH Division of Respiratory Diseases Studies, Morgantown WV, USA. akpinarelcim@ecu.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 100 EP - 107 VL - 1 IS - 2 SN - 1872-213X, 1872-213X KW - Cytokines KW - 0 KW - Index Medicus KW - Sputum -- chemistry KW - Inflammation -- physiopathology KW - Polymorphism, Genetic KW - Humans KW - Breath Tests -- methods KW - Inflammation -- genetics KW - Gene Expression Regulation KW - Patents as Topic KW - Nasal Lavage Fluid -- chemistry KW - Inflammation -- diagnosis KW - Occupational Diseases -- diagnosis KW - Cytokines -- analysis KW - Occupational Diseases -- genetics KW - Cytokines -- genetics KW - Respiratory Tract Diseases -- diagnosis KW - Respiratory Tract Diseases -- genetics KW - Occupational Diseases -- physiopathology KW - Cytokines -- metabolism KW - Respiratory Tract Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70146158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+patents+on+inflammation+%26+allergy+drug+discovery&rft.atitle=Noninvasive+assessment+of+cytokines+in+occupational+respiratory+diseases.&rft.au=Akpinar-Elci%2C+Muge%3BYucesoy%2C+Berran%3BElci%2C+Omur+Cinar%3BWeissman%2C+David+N&rft.aulast=Akpinar-Elci&rft.aufirst=Muge&rft.date=2007-06-01&rft.volume=1&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Recent+patents+on+inflammation+%26+allergy+drug+discovery&rft.issn=1872213X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medical toxicology and public health--update on research and activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry. AN - 69057803; 18074626 JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Schier, Joshua AU - Algren, Adam AD - US Public Health Service, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 85 VL - 3 IS - 2 SN - 1556-9039, 1556-9039 KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - United States KW - Public Health KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Disease Outbreaks KW - Fentanyl -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69057803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.atitle=Medical+toxicology+and+public+health--update+on+research+and+activities+at+the+Centers+for+Disease+Control+and+Prevention+and+the+Agency+for+Toxic+Substances+and+Disease+Registry.&rft.au=Schier%2C+Joshua%3BAlgren%2C+Adam&rft.aulast=Schier&rft.aufirst=Joshua&rft.date=2007-06-01&rft.volume=3&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.issn=15569039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Divergent roles for tumor necrosis factor-alpha in the brain. AN - 68542302; 18040839 AB - Proinflammatory cytokines and chemokines have been implicated in the pathogenesis of several neurological and neurodegenerative disorders. Prominent among such factors is the pleiotropic cytokine, tumor necrosis factor (TNF)-alpha. Under normal physiological conditions, TNF-alpha orchestrates a diverse array of functions involved in immune surveillance and defense, cellular homeostasis, and protection against certain neurological insults. However, paradoxical effects of this cytokine have been observed. TNF-alpha is elicited in the brain following injury (ischemia, trauma), infection (HIV, meningitis), neurodegeneration (Alzheimer's, Parkinson's), and chemically induced neurotoxicity. The multifarious identity for this cytokine appears to be influenced by several mechanisms. Among the most prominent are the regulation of TNFalpha-induced NF-kappaB activation by adapter proteins such as TRADD and TRAF, and second, the heterogeneity of microglia and their distribution pattern across brain regions. Here, we review the differential role of TNF-alpha in response to brain injury, with emphasis on neurodegeneration, and discuss the possible mechanisms for such diverse and region-specific effects. JF - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology AU - Sriram, Krishnan AU - O'Callaghan, James P AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 140 EP - 153 VL - 2 IS - 2 KW - Inflammation Mediators KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Immunologic Surveillance -- immunology KW - Animals KW - Homeostasis -- immunology KW - Humans KW - Immunity, Cellular -- immunology KW - Inflammation Mediators -- toxicity KW - Tumor Necrosis Factor-alpha -- toxicity KW - Brain Chemistry -- immunology KW - Brain Injuries -- immunology KW - Inflammation Mediators -- adverse effects KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- adverse effects KW - Brain Injuries -- prevention & control KW - Inflammation Mediators -- physiology KW - Brain Injuries -- pathology KW - Brain Injuries -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68542302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.atitle=Divergent+roles+for+tumor+necrosis+factor-alpha+in+the+brain.&rft.au=Sriram%2C+Krishnan%3BO%27Callaghan%2C+James+P&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2007-06-01&rft.volume=2&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.issn=1557-1904&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2007-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility. AN - 68453363; 17970221 AB - There is a real need to discover new drugs that are active on drug-resistant tuberculosis (TB), and for drugs that will shorten the time of therapy. Large pharmaceutical companies have traditionally led the quest for discovering and developing new antiinfective agents but this is not the case when it comes to diseases like tuberculosis that primarily occur in resource restricted countries. Throughout the world many research groups are actively engaged in the scientific discovery of new TB drugs. Unfortunately, most research laboratories do not have the necessary safety facilities or resources for all facets of TB drug discovery. The Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) was established in order to make comprehensive testing services available at no cost to research laboratories with an interest in discovering new TB drugs. The TAACF is a consortium of contracts managed and funded by the National Institute of Allergy and Infectious Diseases (National Institutes of Health, Bethesda, MD) as a resource to support preclinical drug discovery and development. The core of the TAACF is the Southern Research Institute, Birmingham, AL, which supports compound acquisition, storage, medicinal chemistry, and high throughput assays. Other collaborating groups provide biological data on antimycobacterial activity and cytotoxicity, preliminary in vivo toxicity, oral bioavailability and efficacy in animal models, specialty testing (such as activity against non-replicating persistent bacteria), and assistance in technology transfer for developing comprehensive promotional packages and facilitating partnerships with pharmaceutical companies for drug development. The TAACF program and recent progress that has been publicly disclosed by suppliers is reviewed. There are many aspects promising of the program that will not be discussed due to confidentially. JF - Infectious disorders drug targets AU - Goldman, R C AU - Laughon, B E AU - Reynolds, R C AU - Secrist, J A AU - Maddry, J A AU - Guié, M-A AU - Poffenberger, A C AU - Kwong, C A AU - Ananthan, S AD - Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Division of AIDS, Therapeutics Research Program, Complications and Coinfections Research Branch, Bethesda, Maryland 20892, USA. rgoldman@niaid.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 92 EP - 104 VL - 7 IS - 2 SN - 1871-5265, 1871-5265 KW - Antitubercular Agents KW - 0 KW - Index Medicus KW - Animals KW - Tuberculosis -- drug therapy KW - Humans KW - Maximum Tolerated Dose KW - Biological Availability KW - Antitubercular Agents -- pharmacokinetics KW - Antitubercular Agents -- pharmacology KW - Drug Evaluation, Preclinical KW - Drug Design KW - Antitubercular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68453363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disorders+drug+targets&rft.atitle=Programs+to+facilitate+tuberculosis+drug+discovery%3A+the+tuberculosis+antimicrobial+acquisition+and+coordinating+facility.&rft.au=Goldman%2C+R+C%3BLaughon%2C+B+E%3BReynolds%2C+R+C%3BSecrist%2C+J+A%3BMaddry%2C+J+A%3BGui%C3%A9%2C+M-A%3BPoffenberger%2C+A+C%3BKwong%2C+C+A%3BAnanthan%2C+S&rft.aulast=Goldman&rft.aufirst=R&rft.date=2007-06-01&rft.volume=7&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Infectious+disorders+drug+targets&rft.issn=18715265&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-20 N1 - Date created - 2007-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a proposed velocity equation for improved exothermic process control. AN - 68193951; 17519275 AB - Exothermic or heated processes create potentially unsafe work environments for an estimated 5-10 million American workers each year. Excessive heat and process contaminants have the potential to cause adverse health effects in exposed workers. Owing to the potential hazards, engineering controls are recommended for these processes. Our understanding of heat transfer and meteorological theories, and their applications for engineering controls have evolved since seminal work was published by Hemeon in 1955. These refined theories were reviewed and used to develop a proposed equation to estimate buoyant plume mean velocity. Mean velocity is a key parameter used to estimate the plume volumetric flow required for controlling effluents from exothermic processes. Subsequent to developing the proposed equation, plume velocity data were collected with a thermal anemometer for a model exothermic process in the laboratory, and an actual exothermic process in the field. Laboratory and field results were then compared to solutions provided by the proposed, American Conference of Governmental Industrial Hygienists (ACGIH), and Hemeon mean velocity equations. To determine which equation most closely matched the laboratory and field data, either t-tests or Wilcoxon Signed Rank tests were conducted (based on examination of data normality) to determine the difference between collected data and solutions from the proposed, ACGIH, and Hemeon equations. Median differences and P-values from Wilcoxon Signed Rank tests (nonparametric) indicate that the ACGIH mean velocity equation provides significantly different estimates from the laboratory and the field mean velocity data. However, the proposed and Hemeon equation provided solutions that were not significantly different from the collected data. These results were unexpected due to the similar developmental backgrounds between the ACGIH and Hemeon equations. Findings indicate that radiant heat flux is an important consideration when using horizontal plate heat transfer equations to estimate plume mean velocity over the range of parameters investigated. Results indicate that the mean velocity equation currently recommended by ACGIH is not as accurate as either the proposed or Hemeon equations over the range of parameters investigated. JF - The Annals of occupational hygiene AU - McKernan, John L AU - Ellenbecker, Michael J AU - Holcroft, Christina A AU - Petersen, Martin R AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation and Field Studies, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA. JMcKernan@cdc.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 357 EP - 369 VL - 51 IS - 4 SN - 0003-4878, 0003-4878 KW - Index Medicus KW - Occupational Exposure KW - Engineering KW - Humans KW - Ventilation KW - Hot Temperature -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68193951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Evaluation+of+a+proposed+velocity+equation+for+improved+exothermic+process+control.&rft.au=McKernan%2C+John+L%3BEllenbecker%2C+Michael+J%3BHolcroft%2C+Christina+A%3BPetersen%2C+Martin+R&rft.aulast=McKernan&rft.aufirst=John&rft.date=2007-06-01&rft.volume=51&rft.issue=4&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychiatric comorbidity and acculturation stress among Puerto Rican substance abusers. AN - 68126725; 17543714 AB - Although acculturation to the United States has been associated with an increase in substance, mood, and anxiety disorders in Latino populations, few studies have examined this concept relative to comorbidity among these syndromes. This study compares the prevalence and patterns of psychiatric comorbidity among Puerto Ricans with substance use disorders living in San Juan (Puerto Rico) to those who have migrated to New Haven (Connecticut) and examines the association between acculturation-related stress and the prevalence and patterns of psychiatric comorbidity among those who have migrated to New Haven. Lifetime levels of nearly all comorbid psychiatric disorders among respondents with substance use disorders were generally similar across sites. However, the risk of any co-occurring psychiatric disorder was higher among substance use disorder cases in New Haven who reported high levels of total acculturation stress and family-specific acculturation stress. These findings were generally accounted for by associations between affective disorders and high scores on these indicators of acculturation stress. The overall prevalence and patterns of psychiatric comorbidity are remarkably similar among Puerto Rican substance abusers whether they live in San Juan or have migrated to New Haven, thereby demonstrating robustness to differences in geographic location. Nevertheless, the degree of acculturation-related family stress is positively associated with co-occurring substance and psychiatric disorders, particularly affective disorders. Intervention in family strain related to the acculturation process may diminish the development of comorbid mental disorders and assist in implementing successful treatment of substance abuse. JF - American journal of preventive medicine AU - Conway, Kevin P AU - Swendsen, Joel D AU - Dierker, Lisa AU - Canino, Glorisa AU - Merikangas, Kathleen R AD - Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-9589, USA. kconway@nida.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - S219 EP - S225 VL - 32 IS - 6 Suppl SN - 0749-3797, 0749-3797 KW - Index Medicus KW - Hispanic Americans KW - Puerto Rico -- ethnology KW - Humans KW - Connecticut -- epidemiology KW - Adult KW - Male KW - Female KW - Comorbidity KW - Acculturation KW - Mental Disorders -- epidemiology KW - Stress, Psychological -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68126725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=Psychiatric+comorbidity+and+acculturation+stress+among+Puerto+Rican+substance+abusers.&rft.au=Conway%2C+Kevin+P%3BSwendsen%2C+Joel+D%3BDierker%2C+Lisa%3BCanino%2C+Glorisa%3BMerikangas%2C+Kathleen+R&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2007-06-01&rft.volume=32&rft.issue=6+Suppl&rft.spage=S219&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Compr Psychiatry. 1988 May-Jun;29(3):309-22 [3378418] J Nerv Ment Dis. 1990 Mar;178(3):161-71 [2307968] Arch Gen Psychiatry. 1989 May;46(5):437-43 [2712662] Br J Addict. 1989 Jul;84(7):801-14 [2758153] J Nerv Ment Dis. 2000 Feb;188(2):90-100 [10695837] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] Br J Psychiatry. 1991 Feb;158:177-82 [2012908] Am Psychol. 1991 Jun;46(6):585-97 [1952420] Br J Psychiatry. 1991 Nov;159:645-53, 658 [1756340] Acta Psiquiatr Psicol Am Lat. 1991 Sep;37(3):191-204 [1811404] Br J Psychiatry. 1992 Jun;160:815-8 [1617365] J Nerv Ment Dis. 1993 Mar;181(3):166-75 [8445375] J Psychiatr Res. 1994 Jan-Feb;28(1):57-84 [8064641] Am Psychol. 1994 Aug;49(8):701-8 [8092613] Am J Orthopsychiatry. 1996 Jan;66(1):17-31 [8720638] J Subst Abuse. 1995;7(4):481-97 [8838629] Soc Psychiatry Psychiatr Epidemiol. 1998 Feb;33(2):80-8 [9503991] Compr Psychiatry. 1998 Jul-Aug;39(4):176-84 [9675501] Arch Gen Psychiatry. 1998 Sep;55(9):771-8 [9736002] Psychiatr Serv. 1999 Oct;50(10):1309-15 [10506299] Arch Gen Psychiatry. 2004 Dec;61(12):1226-33 [15583114] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Clin Psychiatry. 2006 Jan;67(1):56-65 [16426089] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Clin Psychol Rev. 2000 Mar;20(2):173-89 [10721496] Am J Public Health. 2000 Apr;90(4):608-14 [10754977] J Nerv Ment Dis. 2000 Nov;188(11):728-35 [11093374] Arch Gen Psychiatry. 2002 Apr;59(4):375-80 [11926938] Subst Use Misuse. 2002 Mar;37(4):429-56 [12064428] Am J Psychiatry. 2003 May;160(5):890-5 [12727692] Am J Public Health. 2003 Jul;93(7):1057-64 [12835179] J Nerv Ment Dis. 2004 Aug;192(8):532-41 [15387155] J Health Soc Behav. 1987 Mar;28(1):89-102 [3571910] Arch Gen Psychiatry. 1987 Jun;44(6):505-13 [3579499] Arch Gen Psychiatry. 1987 Aug;44(8):720-6 [3498455] Arch Gen Psychiatry. 1987 Dec;44(12):1064-8 [3689094] J Stud Alcohol. 1988 May;49(3):219-24 [3374135] Arch Gen Psychiatry. 1988 Dec;45(12):1069-77 [2848472] N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Preventing Fire Fighter Fatalities Due to Heart Attacks and Other Sudden Cardiovascular Events AN - 58757082; 2007-23622 AB - The National Institute for Occupational Safety and Health (NIOSH) requests assistance in preventing on-duty cardiovascular deaths among U.S. fire fighters. To reduce these deaths, NIOSH recommends that fire departments and fire fighters follow established medical screening guidelines, adopt risk reduction measures during fire fighting operations, and develop and participate in comprehensive wellness/fitness programs. To bring the information and recommendations in this Alert to the attention of the fire service community, NIOSH requests help from the following individuals and organizations: fire commissioners, fire chiefs, State and local fire district administrators, State fire marshals, safety and health officials, health care providers (physicians, nurses, etc.), human resource specialists, unions, labor organizations, insurance companies and editors of trade journals and other publications. Figures. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2007, 32 pp. AU - Baldwin, Tommy AU - Hales, Thomas AU - Jackson, Scott Y1 - 2007/06// PY - 2007 DA - June 2007 EP - 32p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Social conditions and policy - Public safety and security KW - Health conditions and policy - Diseases and disorders KW - Firefighters - Physical and mental fitness KW - Heart disease - Prevention KW - United States - National institute of occupational safety and health KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58757082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Baldwin%2C+Tommy%3BHales%2C+Thomas%3BJackson%2C+Scott&rft.aulast=Baldwin&rft.aufirst=Tommy&rft.date=2007-06-01&rft.volume=&rft.issue=&rft.spage=32p&rft.isbn=&rft.btitle=Preventing+Fire+Fighter+Fatalities+Due+to+Heart+Attacks+and+Other+Sudden+Cardiovascular+Events&rft.title=Preventing+Fire+Fighter+Fatalities+Due+to+Heart+Attacks+and+Other+Sudden+Cardiovascular+Events&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2007-133/pdfs/2007-133.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Illness severity and propensity to travel along the urban-rural continuum AN - 57223495; 200714831 AB - In this paper, we examine whether the relationship between severity of illness and the propensity to travel greater distance relative to the norm (defined by peers in one's county of residence) is uniform across the urban-rural continuum of geography or over time. We focus on the elderly in New York State who have been admitted to hospital for ambulatory care sensitive conditions (ACSCs), admissions which are presumed to be representative of usual travel patterns. The two periods of time examined span the implementation of the Balanced Budget Act (BBA) of 1997, which established the Medicare Rural Hospital Flexibility Program, a major national initiative to strengthen rural health care with the development of rural Critical Access Hospitals (CAHs). As the number of NY rural hospitals certified as CAH increased with the expanded funding from the BBA, one might expect to see increased distance traveled by more severely ill rural elderly, as their CAHs referred them to their affiliated support hospitals. The logistic regression estimates support this expectation, highlighting an asymmetrical relationship between relative distance and severity across patients in rural and urban areas. Despite a general decline in average propensity to travel further than the norm across the landscape, severity had a larger impact on travel propensity in rural areas, which increased over time. [Copyright 2006 Elsevier Ltd.] JF - Health & Place AU - Basu, Jayasree AU - Mobley, Lee R AD - Agency Healthcare Research & Quality, Rockville, MD Jbasu@ahrq.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 381 EP - 399 PB - Elsevier Science, Amsterdam The Netherlands VL - 13 IS - 2 SN - 1353-8292, 1353-8292 KW - Severity of illness, Elderly managed care, Urban and rural, Distance, Travel patterns, Critical access hospital KW - Travel KW - Ambulatory care sensitive KW - Managed care KW - Sick elderly people KW - Rural areas KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57223495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+%26+Place&rft.atitle=Illness+severity+and+propensity+to+travel+along+the+urban-rural+continuum&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-06-01&rft.volume=13&rft.issue=2&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Health+%26+Place&rft.issn=13538292&rft_id=info:doi/10.1016%2Fj.healthplace.2006.03.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - HEPLFG N1 - SubjectsTermNotLitGenreText - Sick elderly people; Ambulatory care sensitive; Hospitals; Rural areas; Managed care; Travel DO - http://dx.doi.org/10.1016/j.healthplace.2006.03.002 ER - TY - JOUR T1 - Challenges in Replicating Interventions AN - 57076038; 200720161 AB - Purpose To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. Methods Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. Results Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention 'to scale' are not discussed. Conclusions Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations. [Copyright 2007 The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Bell, Stephanie G AU - Newcomer, Susan F AU - Bachrach, Christine AU - Borawski, Elaine AU - Jemmott, John B, III AU - Morrison, Diane AU - Stanton, Bonita AU - Tortolero, Susan AU - Zimmerman, Richard AD - Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 514 EP - 520 PB - Elsevier, New York NY VL - 40 IS - 6 SN - 1054-139X, 1054-139X KW - Adolescents KW - Interventions KW - Sexual behavior KW - HIV risk KW - Health risks KW - Sexual behaviour KW - Risk behaviour KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57076038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Challenges+in+Replicating+Interventions&rft.au=Bell%2C+Stephanie+G%3BNewcomer%2C+Susan+F%3BBachrach%2C+Christine%3BBorawski%2C+Elaine%3BJemmott%2C+John+B%2C+III%3BMorrison%2C+Diane%3BStanton%2C+Bonita%3BTortolero%2C+Susan%3BZimmerman%2C+Richard&rft.aulast=Bell&rft.aufirst=Stephanie&rft.date=2007-06-01&rft.volume=40&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2006.09.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Adolescents; Interventions; Risk behaviour; Health risks; HIV; Sexual behaviour DO - http://dx.doi.org/10.1016/j.jadohealth.2006.09.005 ER - TY - JOUR T1 - Properties of model-averaged BMDLs: a study of model averaging in dichotomous response risk estimation AN - 36849295; 3520793 AB - Model averaging (MA) has been proposed as a method of accounting for model uncertainty in benchmark dose (BMD) estimation. The technique has been used to average BMD dose estimates derived from dichotomous dose-response experiments, microbial dose-response experiments, as well as observational epidemiological studies. While MA is a promising tool for the risk assessor, a previous study suggested that the simple strategy of averaging individual models' BMD lower limits did not yield interval estimators that met nominal coverage levels in certain situations, and this performance was very sensitive to the underlying model space chosen. We present a different, more computationally intensive, approach in which the BMD is estimated using the average dose-response model and the corresponding benchmark dose lower bound (BMDL) is computed by bootstrapping. This method is illustrated with TiO2 dose-response rat lung cancer data, and then systematically studied through an extensive Monte Carlo simulation. The results of this study suggest that the MA-BMD, estimated using this technique, performs better, in terms of bias and coverage, than the previous MA methodology. Further, the MA-BMDL achieves nominal the benchmark dose. Although these results show utility of MA for benchmark dose risk estimation, they continue to highlight the importance of choosing an adequate model space as well as proper model fir diagnostic. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Wheeler, Matthew W AU - Bailer, A John AD - National Institute for Occupational Safety and Health Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 659 EP - 670 VL - 27 IS - 3 SN - 0272-4332, 0272-4332 KW - Sociology KW - Risk management KW - Model testing KW - Epidemiology KW - Medical research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36849295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Properties+of+model-averaged+BMDLs%3A+a+study+of+model+averaging+in+dichotomous+response+risk+estimation&rft.au=Wheeler%2C+Matthew+W%3BBailer%2C+A+John&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2007-06-01&rft.volume=27&rft.issue=3&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2007.00920.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11038 7625; 7886 10902; 4357 7894; 8160 8163 DO - http://dx.doi.org/10.1111/j.1539-6924.2007.00920.x ER - TY - JOUR T1 - FDA Drug Approval Summary: Bevacizumab (Avastin+) Plus Carboplatin and Paclitaxel as First-Line Treatment of Advanced/Metastatic Recurrent Nonsquamous Non-Small Cell Lung Cancer AN - 21351958; 7533749 AB - On October 11, 2006, the U.S. Food and Drug Administration granted approval for bevacizumab (Avastin+; Genentech, Inc., South San Francisco, CA), administered in combination with carboplatin and paclitaxel, for the initial treatment of patients with unresectable, locally advanced, recurrent, or metastatic, nonsquamous, non-small cell lung cancer (NSCLC). Approval is based on a significant improvement in overall survival (OS). A randomized, open label, multicenter clinical trial, conducted by the Eastern Cooperative Oncology Group (ECOG), in chemotherapy-naive patients with stage IIIB/IV nonsquamous NSCLC, evaluated bevacizumab plus carboplatin and paclitaxel (BV/CP, n = 434) versus carboplatin and paclitaxel alone (CP, n = 444). Exclusion of patients with squamous or predominantly squamous histology was based on life-threatening or fatal hemoptysis occurring in 4 of 13 patients with squamous histology who received a BV/CP regimen in a phase II study. Among the 878 randomized patients, the median age was 63, 46% were female, 76% had stage IV disease, 12% had stage IIIB disease with malignant pleural effusion, 11% had recurrent disease, and 40% had an ECOG performance status score of 0. OS was significantly longer in patients receiving BV/CP than in those receiving CP alone (median OS, 12.3 versus 10.3 months; hazard ratio [HR], 0.80; p = .013, stratified log rank test). Although a consistent effect was observed across most subgroups, in an exploratory analysis, evidence of a survival benefit was not observed in women (HR, 0.99; 95% confidence interval, 0.79-1.25). Severe and life-threatening adverse events occurring more frequently in patients receiving BV/CP were neutropenia (27% versus 17%), fatigue (16% versus 13%), hypertension (8% versus 0.7%), infection without neutropenia (7% versus 3%), thrombosis/embolism (5% versus 3%), pneumonitis or pulmonary infiltrate (5% versus 3%), infection with grade 3 or 4 neutropenia (5% versus 2%), febrile neutropenia (5% versus 2%), hyponatremia (4% versus 1%), proteinuria (3% versus 0), and headache (3% versus 0.5%). Fatal, treatment-related adverse events in patients receiving bevacizumab were pulmonary hemorrhage (2.3% versus 0.5%), gastrointestinal hemorrhage, central nervous system infarction, gastrointestinal perforation, myocardial infarction, and neutropenic sepsis. The most serious, and sometimes fatal, bevacizumab toxicities are gastrointestinal perforation, wound healing complications, hemorrhage, arterial thromboembolic events, hypertensive crisis, nephrotic syndrome, congestive heart failure, and neutropenic sepsis. The most common adverse events in patients receiving bevacizumab are asthenia, pain, abdominal pain, headache, hypertension, diarrhea, nausea, vomiting, anorexia, stomatitis, constipation, upper respiratory infection, epistaxis, dyspnea, exfoliative dermatitis, and proteinuria. Disclosure of potential conflicts of interest is found at the end of this article. JF - Oncologist AU - Cohen, Martin H AU - Gootenberg, Joe AU - Keegan, Patricia AU - Pazdur, Richard AD - Division of Biological Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 713 EP - 718 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 12 IS - 6 SN - 1083-7159, 1083-7159 KW - Microbiology Abstracts B: Bacteriology KW - Central nervous system KW - Vomiting KW - Nephrotic syndrome KW - Hyponatremia KW - Respiration KW - Non-small cell lung carcinoma KW - Pain KW - Bevacizumab KW - Hemorrhage KW - Thromboembolism KW - Metastases KW - Headache KW - Nausea KW - Dyspnea KW - Diarrhea KW - Fatigue KW - Stomatitis KW - Asthenia KW - Carboplatin KW - Toxicity KW - congestive heart failure KW - Thrombosis KW - Neutropenia KW - Sepsis KW - Proteinuria KW - Embolism KW - anorexia KW - Paclitaxel KW - Constipation KW - Hypertension KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21351958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=FDA+Drug+Approval+Summary%3A+Bevacizumab+%28Avastin%2B%29+Plus+Carboplatin+and+Paclitaxel+as+First-Line+Treatment+of+Advanced%2FMetastatic+Recurrent+Nonsquamous+Non-Small+Cell+Lung+Cancer&rft.au=Cohen%2C+Martin+H%3BGootenberg%2C+Joe%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2007-06-01&rft.volume=12&rft.issue=6&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Central nervous system; Vomiting; Nephrotic syndrome; Hyponatremia; Respiration; Non-small cell lung carcinoma; Pain; Bevacizumab; Hemorrhage; Thromboembolism; Metastases; Headache; Nausea; Dyspnea; Fatigue; Diarrhea; Stomatitis; Asthenia; Toxicity; Carboplatin; congestive heart failure; Thrombosis; Neutropenia; Proteinuria; Sepsis; Paclitaxel; anorexia; Embolism; Constipation; Hypertension ER - TY - JOUR T1 - Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends AN - 21130305; 11176443 AB - This study was aimed at enhancing the physical stability of the drug clotrimazole (CT) and the polymer contained within hot-melt extrusion (HME) films using polymer blends of hydroxypropyl cellulose (HPC) and poly(ethylene oxide) (PEO). The HME films were investigated for solid-state characteristics, moisture sorption, bioadhesivity, mechanical properties, glass transition temperature, release characteristics, and physical and chemical stability of the drug and the polymer within the HME films. The solid-state characterization of the drug and the polymer was performed using differential scanning calorimetry, x-ray diffractometry, and dynamic mechanical analysis. A texture analyzer was used to study the bioadhesive and mechanical properties of the HME films. The physical and chemical stability of the films, stored at 25°C/60% relative humidity or in a desiccator, was studied for up to 12 months. CT was found to be in solid solution within all of the formulations extruded. The physical stability of the drug and PEO in the HME films increased with increasing HPC concentration, but the bioadhesivity and flexibility of the PEO films decreased with increasing HPC concentration. Films containing HPC: PEO∶ CT in the ratio of 55∶ 35∶ 10 demonstrated optimum physical-mechanical, bioadhesive, and release properties. In conclusion, polymer blends of HPC and PEO were used successfully to tailor the drug release, mechanical and bio-adhesive properties, and stability of the HME films. JF - AAPS PharmSciTech AU - Prodduturi, Suneela AU - Urman, Kevin L AU - Otaigbe, Joshua U AU - Repka, Michael A AD - Division of Pharmaceutical Analysis, Food and Drug Administration, 63101 St Louis, MO, marepka@olemiss.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - E152 EP - E161 PB - Springer New York LLC VL - 8 IS - 2 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Relative humidity KW - Temperature effects KW - Drug delivery KW - Sorption KW - Clotrimazole KW - Cellulose KW - Ionizing radiation KW - oxides KW - Drugs KW - Films KW - Mechanical properties KW - Differential scanning calorimetry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21130305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Stabilization+of+hot-melt+extrusion+formulations+containing+solid+solutions+using+polymer+blends&rft.au=Prodduturi%2C+Suneela%3BUrman%2C+Kevin+L%3BOtaigbe%2C+Joshua+U%3BRepka%2C+Michael+A&rft.aulast=Prodduturi&rft.aufirst=Suneela&rft.date=2007-06-01&rft.volume=8&rft.issue=2&rft.spage=E152&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fpt0802050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Relative humidity; Sorption; Drug delivery; Clotrimazole; Ionizing radiation; Cellulose; oxides; Drugs; Differential scanning calorimetry; Mechanical properties; Films DO - http://dx.doi.org/10.1208/pt0802050 ER - TY - JOUR T1 - Murine Aerosol Challenge Model of Anthrax AN - 20983697; 7418037 AB - The availability of relevant and useful animal models is critical for progress in the development of effective vaccines and therapeutics. The infection of rabbits and non-human primates with fully virulent Bacillus anthracis spores provides two excellent models of anthrax disease. However, the high cost of procuring and housing these animals and the specialized facilities required to deliver fully virulent spores limit their practical use in early stages of product development. Conversely, the small size and low cost associated with using mice makes this animal model more practical for conducting experiments in which large numbers of animals are required. In addition, the availability of knockout strains and well-characterized immunological reagents makes it possible to perform studies in mice that cannot be performed easily in other species. Although we, along with others, have used the mouse aerosol challenge model to examine the outcome of B. anthracis infection, a detailed characterization of the disease is lacking. The current study utilizes a murine aerosol challenge model to investigate disease progression, innate cytokine responses, and histological changes during the course of anthrax after challenge with aerosolized spores. Our results show that anthrax disease progression in a complement-deficient mouse after challenge with aerosolized Sterne spores is similar to that described for other species, including rabbits and non-human primates, challenged with fully virulent B. anthracis. Thus, the murine aerosol challenge model is both useful and relevant and provides a means to further investigate the host response and mechanisms of B. anthracis pathogenesis. JF - Infection and Immunity AU - Loving, Crystal L AU - Kennett, Mary AU - Lee, Gloria M AU - Grippe, Vanessa K AU - Merkel, Tod J AD - Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892. Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, State College, Pennysylvania Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2689 EP - 2698 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Aerosols KW - Housing KW - Animal models KW - Anthrax KW - Cytokines KW - Developmental stages KW - Vaccines KW - Bacillus anthracis KW - Spores KW - Infection KW - Primates KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20983697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Murine+Aerosol+Challenge+Model+of+Anthrax&rft.au=Loving%2C+Crystal+L%3BKennett%2C+Mary%3BLee%2C+Gloria+M%3BGrippe%2C+Vanessa+K%3BMerkel%2C+Tod+J&rft.aulast=Loving&rft.aufirst=Crystal&rft.date=2007-06-01&rft.volume=75&rft.issue=6&rft.spage=2689&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Aerosols; Housing; Animal models; Developmental stages; Cytokines; Anthrax; Vaccines; Infection; Spores; Bacillus anthracis; Primates ER - TY - JOUR T1 - Behavioral effects associated with chronic ketamine or remacemide exposure in rats AN - 20845234; 8253002 AB - The effects of chronic exposure to ketamine or remacemide on the acquisition and performance of food-reinforced operant behaviors was assessed in female Sprague-Dawley rats. Ketamine is an anesthetic N-methyl-d-aspartate (NMDA) receptor antagonist, whereas remacemide is an active central nervous system compound with both NMDA receptor antagonist and sodium channel blocking properties. Learning, audio/visual discrimination and motivation were modeled using incremental repeated acquisition (IRA), audio/visual discrimination (AVD) and progressive ratio (PR) tasks, respectively. Ketamine (10 or 100 mg/kg/day), remacemide (100 or 150 mg/kg/day) or water was administered daily (7 days/week) via orogastric gavage beginning on postnatal day (PND) 23 and continuing until PND 257. Monday through Friday behavioral assessments began on PND 27 and continued until PND 383. Chronic treatment with the high dose of ketamine decreased response rate in all tasks suggesting decreased motivation or motoric capabilities. Chronic treatment with ketamine or remacemide had no effect on the acquisition of IRA task performance at any dose tested. While chronic treatment with either high-dose ketamine or low-dose remacemide only delayed the acquisition of AVD task performance for a brief period midway through treatment, chronic treatment with high-dose remacemide delayed the acquisition of AVD task performance until late in treatment. The findings for ketamine are quite different from those of MK-801 (the prototypic NMDA receptor antagonist) in a previous rat study in which MK-801 severely disrupted the acquisition of both IRA and AVD task performances. These observations suggest important differences in the mechanism of action between ketamine and MK-801. For example, ketamine has a much lower binding affinity than MK-801 for the NMDA receptor, the dopamine transporter and the dopamine D2 receptor. In addition, the findings for remacemide observed in rats are in marked contrast with those seen in monkeys where chronic remacemide had profound disruptive effects on the acquisition of both IRA and AVD task performances and suggest important species differences. JF - Neurotoxicology and Teratology AU - Wright, LKM AU - Pearson, E C AU - Hammond, T G AU - Paule, M G AD - National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA, merle.paule@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 348 EP - 359 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 29 IS - 3 SN - 0892-0362, 0892-0362 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Dopamine D2 receptors KW - Central nervous system KW - N-Methyl-D-aspartic acid receptors KW - Motivation KW - Receptor mechanisms KW - Operant conditioning KW - Food KW - Anesthetics KW - Glutamic acid receptors KW - MK-801 KW - Glutamic acid receptors (ionotropic) KW - Visual discrimination learning KW - Dopamine transporter KW - Chronic exposure KW - Ketamine KW - Sodium channels KW - Visual discrimination KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Behavioral+effects+associated+with+chronic+ketamine+or+remacemide+exposure+in+rats&rft.au=Wright%2C+LKM%3BPearson%2C+E+C%3BHammond%2C+T+G%3BPaule%2C+M+G&rft.aulast=Wright&rft.aufirst=LKM&rft.date=2007-06-01&rft.volume=29&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2006.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Central nervous system; N-Methyl-D-aspartic acid receptors; Operant conditioning; Receptor mechanisms; Motivation; Food; Anesthetics; Glutamic acid receptors; Glutamic acid receptors (ionotropic); MK-801; Visual discrimination learning; Dopamine transporter; Chronic exposure; Ketamine; Sodium channels; Visual discrimination DO - http://dx.doi.org/10.1016/j.ntt.2006.12.004 ER - TY - JOUR T1 - History of diabetes mellitus and subsequent prostate cancer risk in the NIH-AARP Diet and Health Study AN - 20728346; 7465839 AB - Objective: A history of diabetes has been hypothesized to decrease prostate cancer risk, but studies have not always considered confounding or effect modification by dietary or lifestyle factors. Methods: We examined the association between diabetes history and subsequent prostate cancer risk in 328,316 men enrolled in the NIH-AARP Diet and Health Study. Participants were ages 50-71 years and without a prostate cancer diagnosis at baseline in 1995. A prior history of physician-diagnosed diabetes was assessed using a self-administered mailed questionnaire. Cases of prostate cancer were ascertained by matching the cohort to state cancer registries. Multivariable relative risks (RR) and 95% confidence intervals (CI) of prostate cancer were estimated using Cox regression. Results: During 5 years and 1,432,676 person-years of follow-up, 11,193 prostate cancer cases were ascertained. The age-adjusted and multivariable RRs of prostate cancer comparing men with diabetes to those without diabetes were 0.69 (95% CI = 0.64, 0.74) and 0.71 (95% CI = 0.66, 0.76), respectively, indicating no important confounding. The inverse association between diabetes and prostate cancer was particularly strong among men in the highest category of routine physical activity at work or home (RR = 0.41; 95% CI = 0.23, 0.74; p value for test of interaction = 0.03). Findings were similar for organ-confined and advanced prostate cancer. Conclusion: Results from this large prospective study suggest that a history of diabetes is associated with a decreased risk of prostate cancer. The relationship strengthened with high levels of routine physical activity. Because increased physical activity is associated with lower circulating levels of insulin and testosterone, our findings support a role of hypoinsulinemia and low androgenicity linking diabetes to decreased prostate cancer risk. JF - Cancer Causes & Control AU - Calton, Brook A AU - Chang, Shih Chen AU - Wright, Margaret E AU - Kipnis, Victor AU - Lawson, Karla AU - Thompson, Frances E AU - Subar, Amy F AU - Mouw, Traci AU - Campbell, David S AU - Hurwitz, Paul AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd., EPS-MSC 7232, Bethesda, MD, 20892, USA, brook.calton@ucsf.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 493 EP - 503 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 5 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - Historical account KW - diabetes mellitus KW - Age KW - insulin KW - prostate cancer KW - physical activity KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20728346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=History+of+diabetes+mellitus+and+subsequent+prostate+cancer+risk+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Calton%2C+Brook+A%3BChang%2C+Shih+Chen%3BWright%2C+Margaret+E%3BKipnis%2C+Victor%3BLawson%2C+Karla%3BThompson%2C+Frances+E%3BSubar%2C+Amy+F%3BMouw%2C+Traci%3BCampbell%2C+David+S%3BHurwitz%2C+Paul%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Calton&rft.aufirst=Brook&rft.date=2007-06-01&rft.volume=18&rft.issue=5&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-0126-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Historical account; Age; diabetes mellitus; insulin; physical activity; prostate cancer; Cancer DO - http://dx.doi.org/10.1007/s10552-007-0126-y ER - TY - JOUR T1 - Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer AN - 20651412; 8079390 AB - We have previously reported significant inverse associations between bladder cancer risk and dietary intake of vitamins B2, B6, B12, folate and protein in a hospital-based bladder cancer case-control study conducted in Spain (1,150 cases; 1,149 controls). Because these dietary factors are involved in the one-carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway. Two SNPs in the CTH gene were significantly associated with bladder cancer risk. OR (95% CI) for heterozygous and the homozygous variants compared to homozygous wild-type individuals were: 1.37 (1.04-1.80) IVS3-66 A > C and 1.22 (1.02-1.45) IVS10-430 C > T. Because the CTH gene is important for glutathione synthesis, we examined interactions with the GSTM1 gene, which codes for glutathione S-transferase u. Increased risk for individuals with the IVS10-430 CT or TT genotype was limited to those with the GSTM1 null genotype (p-interaction = 0.02). No other SNPs were associated with risk of bladder cancer. These findings suggest that common genetic variants in the one-carbon pathway may not play an important role in the etiology of bladder cancer. However, our results provide some evidence that variation in glutathione synthesis may contribute to risk, particularly among individuals who carry a deletion in GSTM1. Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk. JF - International Journal of Cancer AU - Moore, Lee E AU - Malats, Nuria AU - Rothman, Nathaniel AU - Real, Francisco X AU - Kogevinas, Manolis AU - Karami, Sara AU - Garcia-Closas, Reina AU - Silverman, Debra AU - Chanock, Stephen AU - Welch, Robert AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - Dosemeci, Mustafa AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, moorele@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2452 EP - 2458 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 11 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Spain KW - Gene polymorphism KW - Vitamin B6 KW - Methylenetetrahydrofolate reductase KW - Genotypes KW - Glutathione transferase KW - Dietary intake KW - GSTM1 protein KW - vitamins KW - genomics KW - Folic acid KW - GSTM1 gene KW - Diets KW - Etiology KW - Urinary bladder KW - Ingestion KW - Cancer KW - Vitamin B12 KW - Single-nucleotide polymorphism KW - Proteins KW - Metabolism KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Polymorphisms+in+one-carbon+metabolism+and+trans-sulfuration+pathway+genes+and+susceptibility+to+bladder+cancer&rft.au=Moore%2C+Lee+E%3BMalats%2C+Nuria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BKogevinas%2C+Manolis%3BKarami%2C+Sara%3BGarcia-Closas%2C+Reina%3BSilverman%2C+Debra%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BDosemeci%2C+Mustafa%3BGarcia-Closas%2C+Montserrat&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2007-06-01&rft.volume=120&rft.issue=11&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22565 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Etiology; Urinary bladder; Gene polymorphism; Vitamin B6; Methylenetetrahydrofolate reductase; Glutathione transferase; Dietary intake; Cancer; GSTM1 protein; Vitamin B12; Single-nucleotide polymorphism; genomics; Folic acid; GSTM1 gene; Metabolism; Diets; vitamins; Proteins; Genotypes; Ingestion; Spain DO - http://dx.doi.org/10.1002/ijc.22565 ER - TY - JOUR T1 - Knowledge, Attitudes, and Practices Related to Mold Exposure Among Residents and Remediation Workers in Posthurricane New Orleans AN - 20639455; 7518955 AB - To assess knowledge, attitudes, and practices related to mold exposure in postflood New Orleans, the authors surveyed 159 residents and 76 remediation workers, using logistic regression to explore associations. Nearly all answered "yes" to the questionnaire item, "Do you think mold can make people sick?" and most knew respirators were recommended for cleaning mold. Residents (87%) and workers (47%) said they believed that television or radio were the best ways to communicate information about mold. Workers (24%) also suggested employers provided the best means for communication of this information. Few participants reliably used all recommended protective equipment. Residents cited respirator discomfort and unavailability as reasons for noncompliance; workers cited discomfort and inadequate training, with 50% reporting respirator fit testing. Spanish-speaking workers relied on employers for information. Self-employed workers used protective equipment infrequently. The authors recommend that information on postflood mold exposure be disseminated through media and employers, that protective equipment be made readily available for residents, and that workers receive better training and fit testing. In addition, they suggest that targeted approaches may benefit Spanish-speaking workers and the self-employed. JF - Archives of Environmental and Occupational Health AU - Cummings, K J AU - Van Sickle, D AU - Rao, CY AU - Riggs, MA AU - Brown, C M AU - Moolenaar, R L AD - Division of Respiratory Disease Studies, NIOSH/CDC, 1095 Willowdale Rd, MS 2800, Morgantown, WV 26505, USA, cvx5@cdc.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 101 EP - 108 VL - 61 IS - 3 SN - 1933-8244, 1933-8244 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Inventories KW - Bioremediation KW - Training KW - Communication KW - Molds KW - Microbial contamination KW - USA, Louisiana, New Orleans KW - Protective equipment KW - attitudes KW - Natural disasters KW - Hurricanes KW - Communications KW - Respirators KW - Occupational exposure KW - X 24490:Other KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+and+Occupational+Health&rft.atitle=Knowledge%2C+Attitudes%2C+and+Practices+Related+to+Mold+Exposure+Among+Residents+and+Remediation+Workers+in+Posthurricane+New+Orleans&rft.au=Cummings%2C+K+J%3BVan+Sickle%2C+D%3BRao%2C+CY%3BRiggs%2C+MA%3BBrown%2C+C+M%3BMoolenaar%2C+R+L&rft.aulast=Cummings&rft.aufirst=K&rft.date=2007-06-01&rft.volume=61&rft.issue=3&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+and+Occupational+Health&rft.issn=19338244&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inventories; Communication; Molds; Respirators; Occupational exposure; Hurricanes; Communications; Bioremediation; Training; Microbial contamination; Protective equipment; attitudes; Natural disasters; USA, Louisiana, New Orleans ER - TY - JOUR T1 - Ambient UVB and Melanoma Risk in the United States: A Case-Control Analysis AN - 20561324; 9271062 AB - Purpose Exposure to ultraviolet-B (UVB) radiation is a well-established risk factor for human cutaneous malignant melanoma. Intermittent and cumulative exposures from UVB have been estimated most often by interview questionnaire. This study assessed cumulative UVB using a ground-based measurement instrument to estimate the association between UVB and melanoma. Methods Population-based, incident cases of melanoma (n = 380) and frequency-matched controls (n = 364) residing in Connecticut at diagnosis were interviewed between 1987 and 1989 about recreational and vacation activities, sun-protection practices, occupation, and other factors. Using a residential history, regression estimates of lifetime UVB were derived from ambient measures of UVB, adjusted for intermittent exposure. Results Cases and controls received 29% of lifetime mean UVB in the first 15 years of life. Number of days per year in recreational activity during childhood and late adulthood were associated with increased melanoma risk. When estimating lifetime UVB adjusted for intermittent exposure, melanoma risk peaked at a 5.7-fold increased risk in the ninth decile. Conclusion Sporadic and chronic sun exposure play a role in melanoma etiology. Skin-protection practices should be encouraged across levels of sun intensity, not only in childhood but throughout adulthood. Key Words: Malignant Melanoma; Epidemiology; Exposure Assessment; Ultraviolet Rays Abbreviations: OR, odds ratio; CI, confidence interval; UVR, ultraviolet radiation; UVB, ultraviolet radiation-B; MED, minimum erythemal dose; RB, Robertson-Berger JF - Annals of Epidemiology AU - Lea, C Suzanne AU - Scotto, Joseph A AU - Buffler, Patricia A AU - Fine, Judith AU - Barnhill, Raymond L AU - Berwick, Marianne AD - From the Department of Epidemiology and Public Health Biology (C.S.L., P.A.B.), University of California, Berkeley, Berkeley, CA; U.S. Public Health Service (retired, Captain) (J.A.S.); Department of Surgery (J.F.), University of Connecticut Health Center , Farmington, CT; Department of Pathology, University of Miami School of Medicine, Miami, FL (R.L.B.); Cancer Research and Treatment Center, Department of Internal Medicine (M.B.), University of New Mexico, Albuquerque, NM; and Research Triangle Institute, International (C.S.L.), Research Triangle Park, NC, SLea@rti.org Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 447 EP - 453 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 6 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - Historical account KW - Etiology KW - USA, Connecticut KW - Recreation areas KW - Ultraviolet radiation KW - melanoma KW - Children KW - sun KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Ambient+UVB+and+Melanoma+Risk+in+the+United+States%3A+A+Case-Control+Analysis&rft.au=Lea%2C+C+Suzanne%3BScotto%2C+Joseph+A%3BBuffler%2C+Patricia+A%3BFine%2C+Judith%3BBarnhill%2C+Raymond+L%3BBerwick%2C+Marianne&rft.aulast=Lea&rft.aufirst=C&rft.date=2007-06-01&rft.volume=17&rft.issue=6&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; Etiology; Recreation areas; Ultraviolet radiation; melanoma; Children; sun; USA, Connecticut ER - TY - JOUR T1 - The influence of velocity of stretch-shortening contractions on muscle performance during chronic exposure: age effects AN - 20560529; 9280269 AB - Aging increases injury susceptibility and impairs the ability to adapt to repetitive exposures of mechanical loading. The objective of this research was to investigate if movement velocity affects muscle response to a chronic administration of stretch-shortening cycles (SSCs) differently in young vs. old rats. Dorsiflexor muscles of old (30 months, n = 5) and young rats (12 weeks, n = 6) were exposed 3 times/week for 4.5 weeks to a protocol of 80 maximal SSCs per exposure in vivo. Skeletal muscle response was characterized by high- (500/s) and low- (60/s) velocity dynamic performance, which was evaluated using peak eccentric force, isometric pre-stretch force, eccentric force enhancement above the isometric pre-stretch force, negative work, and positive work. The performance of the young and old groups was not statistically different at the start of the exposure. By the end of the exposure, however, a statistical difference was noted-performance increased significantly in the young animals and decreased significantly in the old animals. The SSC velocity had a profound effect on muscle response. The young animals' high- and low-velocity performances increased during the chronic exposure period, whereas the old animals' performances declined. High-velocity performance increased more than low-velocity performance in young animals. In contrast, old animals suffered the most loss in high-velocity performance over the chronic exposure period. A chronic exposure of SSCs results in a significant performance increase in young animals, and a significant performance decrease in old animals. These differences are more profound during high-velocity movements. These findings suggest that age may impair the ability of skeletal muscle to adapt to repetitive mechanical loading, particularly during high-velocity movements.Original Abstract: Le vieillissement augmente le risque de blessures et reduit l'aptitude a s'adapter aux seances repetees de mise en charge. Le but de cette etude est de verifier si la velocite de mouvement suscite la meme reponse musculaire selon l'age chez des rats jeunes et ages a la suite d'une administration chronique d'actions d'etirement-contraction (SSCs) du muscle. Durant 4,5 semaines a raison de 3 fois par semaine, on administre in vivo une serie de 80 SSCs maximales aux flechisseurs dorsaux de jeunes rats (12 semaines, n = 6) et de rats plus ages (30 mois, n = 5). La reponse du muscle squelettique, caracterisee par sa performance dynamique a faible (60/s) et a haute velocite (500/s), est evaluee par la force pliometrique de pointe, la force isometrique precedant l'etirement, le surplus de force pliometrique observe au-dela de la force isometrique precedant l'etirement, le travail negatif et le travail positif. Au debut de la seance, la performance des jeunes rats ne differe pas statistiquement de celles des rats ages. Vers la fin de la seance, on observe une difference statistiquement significative : la performance des jeunes rats augmente significativement et celle des rats ages diminue significativement. La velocite de l'action d'etirement-contraction a un effet marque sur la reponse. La performance a basse et a haute velocite des jeunes rats augmente au cours de la seance d'administration chronique des actions d'etirement-contraction et celle des rats ages diminue. Chez les jeunes rats, la performance a haute velocite augmente plus que celle a basse velocite. En contrepartie, on observe chez les rats plus ages une plus grande diminution de la performance a haute velocite que celle observee a basse velocite au cours de la seance d'administration chronique d'actions d'etirement-contraction. Une seance d'administration chronique d'actions d'etirement-contraction cause une augmentation significative de la performance chez les jeunes rats et une diminution significative chez les rats plus ages. Ces differences sont plus importantes au cours de mouvements executes a haute velocite. Ces observations laissent entendre que le vieillissement peut reduire l'aptitude du muscle squelettique a s'adapter a une mise en charge repetitive, et ce, particulierement au cours de mouvements executes a haute velocite. JF - Applied Physiology, Nutrition, and Metabolism AU - Cutlip, Robert G AU - Baker, Brent A AU - Geronilla, Ken B AU - Kashon, Michael L AU - Wu, John Z AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA., rgc8@cdc.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 443 EP - 453 PB - NRC Research Press VL - 32 IS - 3 SN - 1715-5312, 1715-5312 KW - Physical Education Index KW - in vivo dynamometry KW - SSCs KW - skeletal muscle KW - chronic exposure KW - dynamometrie in vivo KW - actions d'etirement-contraction KW - muscle squelettique KW - exposition repetee KW - Muscles (function) KW - Animal subjects KW - Muscles KW - Velocity KW - Work KW - Isometrics KW - Performance KW - Movement KW - Youth KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20560529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.atitle=The+influence+of+velocity+of+stretch-shortening+contractions+on+muscle+performance+during+chronic+exposure%3A+age+effects&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BGeronilla%2C+Ken+B%3BKashon%2C+Michael+L%3BWu%2C+John+Z&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2007-06-01&rft.volume=32&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.issn=17155312&rft_id=info:doi/10.1139%2FH07-014 LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Muscles (function); Animal subjects; Muscles; Isometrics; Work; Velocity; Performance; Movement; Youth DO - http://dx.doi.org/10.1139/H07-014 ER - TY - JOUR T1 - The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression AN - 20553834; 7894365 AB - The secreted Mycobacterium tuberculosis protein, ESAT6, has been studied extensively in pathogenicity and vaccine experiments. Despite these studies little is known about the function of this protein. In this report, we demonstrate that ESAT6 induces apoptosis in THP-1 human macrophages using fluorescein isothiocyanate-Annexin V and intracellular caspase staining. We show that the induction of apoptosis by ESAT6 is dependent on the dose of the protein and the expression of caspase genes. Using real-time RT-PCR, we found that expression of caspase-1, -3, -5, -7 and -8 genes was upregulated in cells treated with ESAT6 relative to untreated cells. Furthermore, we show that while infection of THP-1 cells with wild-type M. tuberculosis strain H37Rv resulted in significant apoptosis 48 h post infection, a deletion mutant that does not express ESAT6 failed to induce significant apoptosis. Finally, experimental results using a cell impermeable fluorescent stain suggests that the formation of membrane pores may be a primary mechanism by which ESAT6 evokes an apoptotic response. JF - Cellular Microbiology AU - Derrick, Steven C AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA., steven.derrick@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1547 EP - 1555 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 6 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Deletion mutant KW - Apoptosis KW - Stains KW - Infection KW - fluorescein KW - Pores KW - Pathogenicity KW - Polymerase chain reaction KW - Caspase-1 KW - Tuberculosis KW - Vaccines KW - ESAT-6 antigen KW - Mycobacterium tuberculosis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20553834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=The+ESAT6+protein+of+Mycobacterium+tuberculosis+induces+apoptosis+of+macrophages+by+activating+caspase+expression&rft.au=Derrick%2C+Steven+C%3BMorris%2C+Sheldon+L&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2007-06-01&rft.volume=9&rft.issue=6&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00892.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Apoptosis; Deletion mutant; Stains; Infection; fluorescein; Pores; Pathogenicity; Polymerase chain reaction; Tuberculosis; Caspase-1; Vaccines; ESAT-6 antigen; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1462-5822.2007.00892.x ER - TY - JOUR T1 - Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity AN - 20479453; 8017914 AB - Nanoparticles agglomerate and clump in solution, making it difficult to accurately deliver them for in vivo or in vitro experiments. Thus, experiments were conducted to determine the best method to suspend nanosized particles. Ultrafine and fine carbon black and titanium dioxide were suspended in phosphate buffered saline (PBS), rat and mouse bronchoalveolar lavage fluid (BALF), and PBS containing dipalmitoyl phosphatidylcholine (DPPC) and/or mouse serum albumin. To assess and compare how these various suspension media dispersed the nanoparticles, images were taken using light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results of this study show that PBS is not a satisfactory medium to prepare nanoparticle suspensions. However, BALF was an excellent media in which to suspend nanoparticles. The use of PBS containing protein or DPPC alone, in concentrations found in BALF, did not result in satisfactory particle dispersion. However, PBS-containing protein plus DPPC was satisfactory, although less effective than BALF. JF - Nanotoxicology AU - Sager, Tina M AU - Porter, Dale W AU - Robinson, Victor A AU - Lindsley, William G AU - Schwegler-Berry, Diane E AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 118 EP - 129 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 1 IS - 2 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Scanning electron microscopy KW - Carbon KW - Titanium dioxide KW - Bronchus KW - Phosphate KW - Transmission electron microscopy KW - Albumin KW - Lecithin KW - Toxicity KW - nanoparticles KW - Alveoli KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20479453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Improved+method+to+disperse+nanoparticles+for+in+vitro+and+in+vivo+investigation+of+toxicity&rft.au=Sager%2C+Tina+M%3BPorter%2C+Dale+W%3BRobinson%2C+Victor+A%3BLindsley%2C+William+G%3BSchwegler-Berry%2C+Diane+E%3BCastranova%2C+Vincent&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2007-06-01&rft.volume=1&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390701381596 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Scanning electron microscopy; Titanium dioxide; Carbon; Phosphate; Bronchus; Transmission electron microscopy; Albumin; Lecithin; Toxicity; nanoparticles; Alveoli DO - http://dx.doi.org/10.1080/17435390701381596 ER - TY - JOUR T1 - Selection of differentially expressed genes in microarray data analysis AN - 20457159; 7520884 AB - One common objective in microarray experiments is to identify a subset of genes that express differentially among different experimental conditions, for example, between drug treatment and no drug treatment. Often, the goal is to determine the underlying relationship between poor versus good gene signatures for identifying biological functions or predicting specific therapeutic outcomes. Because of the complexity in studying hundreds or thousands of genes in an experiment, selection of a subset of genes to enhance relationships among the underlying biological structures or to improve prediction accuracy of clinical outcomes has been an important issue in microarray data analysis. Selection of differentially expressed genes is a two-step process. The first step is to select an appropriate test statistic and compute the P-value. The genes are ranked according to their P-values as evidence of differential expression. The second step is to assign a significance level, that is, to determine a cutoff threshold from the P-values in accordance with the study objective. In this paper, we consider four commonly used statistics, t-, S- (SAM), U-(Mann-Whitney) and M-statistics to compute the P-values for gene ranking. We consider the family-wise error and false discovery rate false-positive error-controlled procedures to select a limited number of genes, and a receiver-operating characteristic (ROC) approach to select a larger number of genes for assigning the significance level. The ROC approach is particularly useful in genomic/genetic profiling studies. The well-known colon cancer data containing 22 normal and 40 tumor tissues are used to illustrate different gene ranking and significance level assignment methods for applications to genomic/genetic profiling studies. The P-values computed from the t-, U- and M-statistics are very similar. We discuss the common practice that uses the P-value, false-positive error probability, as the primary criterion, and then uses the fold-change as a surrogate measure of biological significance for gene selection. The P-value and the fold-change can be pictorially shown simultaneously in a volcano plot. We also address several issues on gene selection. JF - Pharmacogenomics Journal AU - Chen, J J AU - Wang, S-J AU - Tsai, C-A AU - Lin, C-J AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, US Food and Drug Administration, HFT-20, Jefferson, AR 72079, USA, jchen@nctr.fda.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 212 EP - 220 VL - 7 IS - 3 SN - 1470-269X, 1470-269X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Data processing KW - Training KW - genomics KW - Colon cancer KW - Tumors KW - Drugs KW - W 30915:Pharmaceuticals & Vaccines KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics+Journal&rft.atitle=Selection+of+differentially+expressed+genes+in+microarray+data+analysis&rft.au=Chen%2C+J+J%3BWang%2C+S-J%3BTsai%2C+C-A%3BLin%2C+C-J&rft.aulast=Chen&rft.aufirst=J&rft.date=2007-06-01&rft.volume=7&rft.issue=3&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics+Journal&rft.issn=1470269X&rft_id=info:doi/10.1038%2Fsj.tpj.6500412 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Training; Tumors; Colon cancer; genomics; Drugs DO - http://dx.doi.org/10.1038/sj.tpj.6500412 ER - TY - JOUR T1 - Building systems to support development of drugs for biodefense AN - 20378747; 7761832 AB - The mission of the National Institute of Allergy and Infectious Diseases (NIAID), Division of Microbiology and Infectious Diseases (DMID), is to support research and product development that addresses the control and prevention of infectious diseases. This mission includes the development of new drugs to mitigate illness, suffering, and death resulting from an expanding spectrum of naturally emerging diseases and potential biological weapons. DMID has established new resources and additional infrastructure to address these challenges. In addition, DMID plans to transition to a new paradigm for research and development approaches based on three concepts that comprise a broad spectrum approach: products with broad spectrum activity; broad spectrum technology that can be applied to improve specific drug characteristics (e.g., shelf life); and broad spectrum platforms that will reduce the time and cost to manufacture and evaluate products. JF - Drug Development Research AU - Taylor, Katherine A AD - Office of Biodefense Research Affairs, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, kataylor@niaid.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 183 EP - 185 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 68 IS - 4 SN - 0272-4391, 0272-4391 KW - Biotechnology and Bioengineering Abstracts KW - Hypersensitivity KW - Infectious diseases KW - Drug development KW - Shelf life KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20378747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Building+systems+to+support+development+of+drugs+for+biodefense&rft.au=Taylor%2C+Katherine+A&rft.aulast=Taylor&rft.aufirst=Katherine&rft.date=2007-06-01&rft.volume=68&rft.issue=4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.20180 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Infectious diseases; Drug development; Shelf life DO - http://dx.doi.org/10.1002/ddr.20180 ER - TY - JOUR T1 - Tubulin Is a Neuronal Target of Autoantibodies in Sydenham's Chorea AN - 19878698; 7419321 AB - Sydenham's chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbs 24.3.1, 31.1.1, and 37.2.1 derived from chorea and selected for cross-reactivity with group A streptococci and brain Ags. Our novel findings reveal that Sydenham's chorea mAbs target a 55-kDa brain protein with an N-terminal amino acid sequence of MREIVHLQ corresponding to beta -tubulin. Chorea mAb specificity for purified brain tubulin was confirmed in ELISA and Western immunoblot, and significant levels of anti-tubulin IgG were found in acute chorea sera and cerebrospinal fluid. Lysoganglioside G sub(M1) inhibited binding of chorea mAbs to tubulin and mAb reactivity with human caudate and putamen brain sections was blocked by anti-tubulin mAb. The chorea mAbs labeled both intra- and extracellular Ags of a neuronal cell line providing evidence suggesting mimicry between intracellular brain protein tubulin and extracellular lysoganglioside. In addition, chorea mAb 24.3.1 and acute chorea sera induced calcium/calmodulin-dependent protein kinase II activity in human neuronal cells. Nucleotide sequence analysis of the chorea mAb V sub(H) genes revealed that mAb 24.3.1 V sub(H) gene was encoded by the V sub(H)1 germline gene family which encodes other anti-ganglioside V sub(H) genes associated with motor neuropathies. mAb recognition of tubulin and the neuronal cell surface with initiation of cell signaling and dopamine release supports an emerging theme in autoimmunity whereby cross-reactive or polyreactive autoantibodies against intracellular Ags recognize cell surface epitopes potentially leading to disease. JF - Journal of Immunology AU - Kirvan, Christine A AU - Cox, Carol J AU - Swedo, Susan E AU - Cunningham, Madeleine W AD - Department of Biological Sciences, California State University, Sacramento, CA 95819. Department of Microbiology and Immunology, University of Oklahoma, Oklahoma, City, OK 73104. Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 7412 EP - 7421 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 11 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; CSA Neurosciences Abstracts KW - Cell surface KW - Central nervous system KW - Cross-reactivity KW - Calcium KW - Nucleotide sequence KW - Autoimmune diseases KW - Infection KW - Putamen KW - Mental disorders KW - Cerebrospinal fluid KW - Dopamine KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - Epitopes KW - Neuropathy KW - Streptococcus KW - Intracellular signalling KW - Mimicry KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Brain KW - Chorea KW - Autoantibodies KW - Ca super(2+)/calmodulin-dependent protein kinase KW - Immunoglobulin G KW - Tubulin KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - J 02350:Immunology KW - F 06930:Autoimmunity KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19878698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Tubulin+Is+a+Neuronal+Target+of+Autoantibodies+in+Sydenham%27s+Chorea&rft.au=Kirvan%2C+Christine+A%3BCox%2C+Carol+J%3BSwedo%2C+Susan+E%3BCunningham%2C+Madeleine+W&rft.aulast=Kirvan&rft.aufirst=Christine&rft.date=2007-06-01&rft.volume=178&rft.issue=11&rft.spage=7412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Cell surface; Calcium; Cross-reactivity; Nucleotide sequence; Autoimmune diseases; Infection; Putamen; Cerebrospinal fluid; Mental disorders; Dopamine; Ca super(2+)/calmodulin-dependent protein kinase II; Epitopes; Neuropathy; Mimicry; Intracellular signalling; Enzyme-linked immunosorbent assay; Monoclonal antibodies; Brain; Chorea; Autoantibodies; Ca super(2+)/calmodulin-dependent protein kinase; Immunoglobulin G; Tubulin; Amino acid sequence; Streptococcus ER - TY - JOUR T1 - QA/QC issues to aid regulatory acceptance of microarray gene expression data AN - 19878420; 7763388 AB - The U.S. Food and Drug Administration is responsible for (1) promoting and protecting public health by assuring the safety and effectiveness of medicines and medical devices and (2) advancing public health by helping to speed innovations that make medicines and foods safer, more effective, and more affordable. The genomics revolution has dramatically increased our knowledge of basic biology but this has not resulted in the expected acceleration of new medical product development. The Agency's Critical Path to New Medical Products stresses that new tools are needed to address this pipeline problem. Microarray technology is one of these promising tools although questions have risen about the reproducibility of measurements. The Microarray Quality Control (MAQC) Project was initiated by FDA scientists to address this issue. This large project, which evaluated reference RNA samples on seven microarray platforms, found good intralaboratory repeatability and interlaboratory reproducibility. In addition, there was high cross-platform consistency. All data are available free of cost and the reference RNA samples are available for proficiency testing. Thus, current microarray technology appears to provide both reliability and consistency for regulatory submissions. JF - Environmental and Molecular Mutagenesis AU - Fuscoe, James C AU - Tong, Weida AU - Shi, Leming AD - Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, james.fuscoe@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 349 EP - 353 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 5 SN - 0893-6692, 0893-6692 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Quality control KW - Stress KW - genomics KW - DNA microarrays KW - Public health KW - Mutagenesis KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19878420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=QA%2FQC+issues+to+aid+regulatory+acceptance+of+microarray+gene+expression+data&rft.au=Fuscoe%2C+James+C%3BTong%2C+Weida%3BShi%2C+Leming&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2007-06-01&rft.volume=48&rft.issue=5&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; RNA; Quality control; Stress; genomics; DNA microarrays; Mutagenesis; Public health DO - http://dx.doi.org/10.1002/em.20293 ER - TY - JOUR T1 - Blood Folate Levels and Risk of Liver Damage and Hepatocellular Carcinoma in a Prospective High-Risk Cohort AN - 19854802; 7461226 AB - Background: Studies in experimental animals suggest that low folate levels may play a role in liver damage and hepatocarcinogenesis. To examine this association in humans, folate levels in blood and risk for subsequent liver damage and hepatocellular carcinoma (HCC) were assessed in a population at high risk of liver cancer in China. Methods: Four hundred fifteen hepatitis B surface antigen-positive participants of the Haimen City Cohort were prospectively followed between 1998 and 2002. Serum and RBC folate levels were determined at baseline. Alanine aminotransferase (ALT) and hepatitis B virus DNA levels were measured semiannually. Logistic regression modeling was used to examine the presence of hepatitis B virus DNA and HCC, whereas linear regression with a log-link function was used to examine ALT levels. Results: There was a statistically significant inverse association between serum folate level and ALT level. ALT levels decreased with each quartile increase in serum folate (adjusted odds ratio, 0.86; 95% confidence interval, 0.76-0.97 for the highest compared with the lowest quartile; P sub(trend) = 0.002). After exclusion of three persons with prevalent HCC, 20 (4.9%) of the 412 study participants developed HCC during follow-up, with a median time between enrollment and HCC diagnosis of 2.66 years (interquartile range, 1.8-4.1). When comparing persons in the lowest quartile RBC folate to persons in all other quartiles, the analysis found that higher RBC folate levels were associated with reduced risk of hepatocarcinogenesis (odds ratio, 0.33, 95% confidence interval, 0.13-0.86; P sub(trend) = 0.02). Conclusions: This study suggests that increased folate levels in humans may be inversely associated with the development of liver damage and HCC. (Cancer Epidemiol Biomarkers Prev 2007; 6(6):1279-82) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Welzel, Tania M AU - Katki, Hormuzd A AU - Sakoda, Lori C AU - Evans, Alison A AU - London, WThomas AU - Chen, Gang AU - O'Broin, Sean AU - Shen, Fu-Min AU - Lin, Wen-Yao AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1279 EP - 1282 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Bioindicators KW - Hepatitis B virus KW - Liver cancer KW - Statistical analysis KW - hepatitis B KW - Alanine transaminase KW - biomarkers KW - Cancer KW - risk reduction KW - Blood KW - Risk factors KW - Liver KW - prevention KW - DNA KW - Hepatitis B KW - Risk groups KW - China, People's Rep. KW - Folic acid KW - Urban areas KW - Hepatocellular carcinoma KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Blood+Folate+Levels+and+Risk+of+Liver+Damage+and+Hepatocellular+Carcinoma+in+a+Prospective+High-Risk+Cohort&rft.au=Welzel%2C+Tania+M%3BKatki%2C+Hormuzd+A%3BSakoda%2C+Lori+C%3BEvans%2C+Alison+A%3BLondon%2C+WThomas%3BChen%2C+Gang%3BO%27Broin%2C+Sean%3BShen%2C+Fu-Min%3BLin%2C+Wen-Yao%3BMcGlynn%2C+Katherine+A&rft.aulast=Welzel&rft.aufirst=Tania&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; Liver cancer; Risk factors; Statistical analysis; Hepatitis B; DNA; Risk groups; Alanine transaminase; Folic acid; biomarkers; Hepatocellular carcinoma; Bioindicators; risk reduction; prevention; Liver; hepatitis B; Cancer; Urban areas; Hepatitis B virus; China, People's Rep. ER - TY - JOUR T1 - In-cab noise reduction on an air-rotary drill rig AN - 19711300; 7520143 AB - The National Institute for Occupational Safety and Health (NIOSH) has investigated engineering noise controls to reduce sound levels in cabs on air-rotary drill rigs. A recent investigation revealed that some drillers are exposed to A-weighted sound levels exceeding 85 dB even though a cab is used. NIOSH studied the in-cab sound levels of one such rig. First, preliminary tests were conducted in a controlled environment using accelerometers and microphones with spectral analysis to identify the dominant noise sources for in-cab sound levels. The results indicate that vibration transmitted from multiple hydraulic pumps to the control panel produces a dominant spike in the sound level spectrum in the 400 Hz 1/3-octave band. Next, field tests were performed in a production environment to evaluate noise controls to reduce in-cab sound levels. It was found that utilizing hydraulic noise suppressors reduces the structure-borne noise transmitted to the control panel. Further, using hydraulic noise suppressors and enhancing soundproofing reduced the in-cab A-weighted sound levels by as much as 4 dB. JF - Noise Control Engineering Journal AU - Yantek, D S AU - Ingram, D K AU - Matetic, R J AD - NIOSH Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh PA 15236, USA, DYantek@cdc.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 294 EP - 310 VL - 55 IS - 3 SN - 0736-2501, 0736-2501 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Hydraulics KW - Vibration KW - Machinery KW - microphones KW - accelerometers KW - Noise reduction KW - Occupational exposure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=In-cab+noise+reduction+on+an+air-rotary+drill+rig&rft.au=Yantek%2C+D+S%3BIngram%2C+D+K%3BMatetic%2C+R+J&rft.aulast=Yantek&rft.aufirst=D&rft.date=2007-06-01&rft.volume=55&rft.issue=3&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hydraulics; Machinery; Vibration; microphones; accelerometers; Noise reduction; Occupational exposure ER - TY - JOUR T1 - Preventing Excessive Weight Gain in Adolescents: Interpersonal Psychotherapy for Binge Eating AN - 19695341; 7464276 AB - The most prevalent disordered eating pattern described in overweight youth is loss of control (LOC) eating, during which individuals experience an inability to control the type or amount of food they consume. LOC eating is associated cross-sectionally with greater adiposity in children and adolescents and seems to predispose youth to gain weight or body fat above that expected during normal growth, thus likely contributing to obesity in susceptible individuals. No prior studies have examined whether LOC eating can be decreased by interventions in children or adolescents without full-syndrome eating disorders or whether programs reducing LOC eating prevent inappropriate weight gain attributable to LOC eating. Interpersonal psychotherapy, a form of therapy that was designed to treat depression and has been adapted for the treatment of eating disorders, has shown efficacy in reducing binge eating episodes and inducing weight stabilization among adults diagnosed with binge eating disorder. In this paper, we propose a theoretical model of excessive weight gain in adolescents at high risk for adult obesity who engage in LOC eating and associated overeating patterns. A rationale is provided for interpersonal psychotherapy as an intervention to slow the trajectory of weight gain in at-risk youth, with the aim of preventing or ameliorating obesity in adulthood. JF - Obesity Research AU - Tanofsky-Kraff, Marian AU - Wilfley, Denise E AU - Young, Jami F AU - Mufson, Laura AU - Yanovski, Susan Z AU - Glasofer, Deborah R AU - Salaita, Christine G AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, Maryland. Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Weight Management and Eating Disorders Program, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York. Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1345 EP - 1355 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Programs KW - Depression KW - Eating disorders KW - Adolescence KW - Diet (weight control) KW - Therapy KW - Adults KW - Children KW - Experience KW - Youth KW - Self efficacy KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Preventing+Excessive+Weight+Gain+in+Adolescents%3A+Interpersonal+Psychotherapy+for+Binge+Eating&rft.au=Tanofsky-Kraff%2C+Marian%3BWilfley%2C+Denise+E%3BYoung%2C+Jami+F%3BMufson%2C+Laura%3BYanovski%2C+Susan+Z%3BGlasofer%2C+Deborah+R%3BSalaita%2C+Christine+G&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2007-06-01&rft.volume=15&rft.issue=6&rft.spage=1345&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Experience; Obesity; Programs; Depression; Eating disorders; Adolescence; Therapy; Diet (weight control); Adults; Children; Youth; Self efficacy ER - TY - JOUR T1 - Serum and Dietary Vitamin E in Relation to Prostate Cancer Risk AN - 19695237; 7461222 AB - alpha -Tocopherol supplementation (50 mg daily for 5-8 years) reduced prostate cancer incidence by 32% in the alpha -Tocopherol, {szligbeta}-Carotene Cancer Prevention Study. We investigated whether serum alpha -tocopherol or intake of vitamin E (eight tocopherols and tocotrienols) was associated with prostate cancer risk with up to 19 years of follow-up in the alpha -Tocopherol, {szligbeta}-Carotene Cancer Prevention Study cohort. Of the 29,133 Finnish male smokers, ages 50 to 69 years recruited into the study, 1,732 were diagnosed with incident prostate cancer between 1985 and 2004. Baseline serum alpha -tocopherol was measured by high-performance liquid chromatography and the components of vitamin E intake were estimated based on a 276-item food frequency questionnaire and food chemistry analyses. Proportional hazard models were used to determine multivariate-adjusted relative risks (RR) and 95% confidence intervals (95% CI). Higher serum alpha -tocopherol was associated with reduced risk of prostate cancer (RR, 0.80; 95% CI, 0.66-0.96 for highest versus lowest quintile; P sub(trend) = 0.03) and was strongly and inversely related to the risk of developing advanced disease (RR, 0.56; 95% CI, 0.36-0.85; P sub(trend) = 0.002). The inverse serum alpha -tocopherol-prostate cancer association was greater among those who were supplemented with either alpha -tocopherol or {szligbeta}-carotene during the trial. There were no associations between prostate cancer and the individual dietary tocopherols and tocotrienols. In summary, higher prediagnostic serum concentrations of alpha -tocopherol, but not dietary vitamin E, was associated with lower risk of developing prostate cancer, particularly advanced prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007; 16(6):1253-9) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Weinstein, Stephanie J AU - Wright, Margaret E AU - Lawson, Karla A AU - Snyder, Kirk AU - Maennistoe, Satu AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1253 EP - 1259 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - vitamins KW - Risk Abstracts KW - Diets KW - Bioindicators KW - risk reduction KW - Liquid chromatography KW - prevention KW - prostate cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+and+Dietary+Vitamin+E+in+Relation+to+Prostate+Cancer+Risk&rft.au=Weinstein%2C+Stephanie+J%3BWright%2C+Margaret+E%3BLawson%2C+Karla+A%3BSnyder%2C+Kirk%3BMaennistoe%2C+Satu%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Weinstein&rft.aufirst=Stephanie&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bioindicators; Diets; risk reduction; Liquid chromatography; prevention; prostate cancer ER - TY - JOUR T1 - Birth Weight, Postnatal Growth, and Risk for High Blood Pressure at 7 Years of Age: Results From the Collaborative Perinatal Project AN - 19687763; 7464414 AB - OBJECTIVE. A physiologic predisposition toward hypertension is theorized to result from the combination of intrauterine growth restriction followed by rapid catch-up growth. The objective of this study was to evaluate the effects of birth weight and weight gain during childhood on the risk for high blood pressure in childhood and to identify discrete periods of catch-up growth that put children with intrauterine growth restriction at increased risk for the development of high blood pressure later in life. METHODS. The US Collaborative Perinatal Project (1959-1974) studied 55908 pregnancies in an observational cohort at 12 medical centers in the United States and followed the offspring through 7 years of age. All white or black children who were born at term and completed the follow-up without kidney or heart disease were included in this posthoc analysis. z scores were calculated for weight at birth, 4 months, 1 year, 4 years, and 7 years on the basis of study means and SD. Changes in z scores were calculated for each interval. RESULTS. Each 1-kg increase in birth weight increased the odds for high systolic blood pressure by 2.19 and high diastolic blood pressure by 1.82 when race and change in weight z scores were also included in the regression model. An increase in weight z score of 1 SD above the previous weight z score increased the odds for high systolic blood pressure at 7 years by 1.65 (birth to 4 months), 1.79 (4 months to 1 year), 1.71 (1-4 years), and 1.94 (4-7 years) in the full model. White race increased the odds for high systolic blood pressure by 1.51. CONCLUSIONS. In this large biracial US cohort, infants who were small for gestational age were not at increased risk for high blood pressure at 7 years of age. However, children who crossed weight percentiles upward during early childhood did demonstrate an increased risk. JF - Pediatrics AU - Hemachandra, Anusha H AU - Howards, Penelope P AU - Furth, Susan L AU - Klebanoff, Mark A AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Divisions of Neonatology. Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - e1264 EP - e1270 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 119 IS - 6 SN - 0031-4005, 0031-4005 KW - Risk Abstracts KW - USA KW - Growth KW - Age KW - low-birth-weight KW - hypertension KW - Kidney KW - birth weight KW - Children KW - offspring KW - Infants KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Birth+Weight%2C+Postnatal+Growth%2C+and+Risk+for+High+Blood+Pressure+at+7+Years+of+Age%3A+Results+From+the+Collaborative+Perinatal+Project&rft.au=Hemachandra%2C+Anusha+H%3BHowards%2C+Penelope+P%3BFurth%2C+Susan+L%3BKlebanoff%2C+Mark+A&rft.aulast=Hemachandra&rft.aufirst=Anusha&rft.date=2007-06-01&rft.volume=119&rft.issue=6&rft.spage=e1264&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Growth; hypertension; low-birth-weight; Kidney; birth weight; Children; Pregnancy; Infants; offspring; USA ER - TY - JOUR T1 - Comparison of Proliferative and Multilineage Differentiation Potential of Human Mesenchymal Stem Cells Derived from Umbilical Cord and Bone Marrow AN - 19687284; 7465189 AB - Human umbilical cord perivascular cells (HUCPVCs) have been shown to have a high proliferative potential and the capacity to differentiate into an osteogenic phenotype. HUCPVCs have thus been considered a possible extra-embryonic mesenchymal stem cell (MSC) source for cell-based therapies. To assess this potential, we compared HUCPVCs to the "gold standard" bone marrow mesenchymal stromal cells (BMSCs) with respect to their proliferation, differentiation, and transfection capacities. HUCPVCs showed a higher proliferative potential than BMSCs and were capable of osteogenic, chondrogenic, and adipogenic differentiation. Interestingly, osteogenic differentiation of HUCPVCs proceeded more rapidly than BMSCs. Additionally, HUCPVCs expressed higher levels of CD146, a putative MSC marker, relative to BMSCs. HUCPVCs showed comparable transfection efficiency as BMSCs using a nucleofection method but were more amenable to transfection with liposomal methods (FuGENE). Gene array analysis showed that HUCPVCs also expressed Wnt signaling pathway genes that have been implicated in the regulation of MSCs. The similar characteristics between HUCPVCs and MSCs support the applicability of HUCPVCs for cell-based therapies. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Baksh, Dolores AU - Yao, Raphael AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1384 EP - 1392 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Stem cells KW - Wnt protein KW - stromal cells KW - Transfection KW - Bone marrow KW - Mesenchyme KW - Cell proliferation KW - Umbilical cord KW - Signal transduction KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Comparison+of+Proliferative+and+Multilineage+Differentiation+Potential+of+Human+Mesenchymal+Stem+Cells+Derived+from+Umbilical+Cord+and+Bone+Marrow&rft.au=Baksh%2C+Dolores%3BYao%2C+Raphael%3BTuan%2C+Rocky+S&rft.aulast=Baksh&rft.aufirst=Dolores&rft.date=2007-06-01&rft.volume=25&rft.issue=6&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Wnt protein; stromal cells; Transfection; Bone marrow; Cell proliferation; Mesenchyme; Umbilical cord; Signal transduction ER - TY - JOUR T1 - A Prospective Study of Tobacco, Alcohol, and the Risk of Esophageal and Gastric Cancer Subtypes AN - 19686292; 7460149 AB - Rates of esophageal adenocarcinoma and gastric cardia adenocarcinoma have increased, while rates of esophageal squamous cell carcinoma (ESCC) and gastric noncardia adenocarcinoma have decreased, suggesting distinct etiologies. The authors prospectively investigated the associations of alcohol and tobacco with these cancers in 474,606 US participants using Cox models adjusted for potential confounders. Between 1995/1996 and 2000, 97 incident cases of ESCC, 205 of esophageal adenocarcinoma, 188 of gastric cardia, and 187 of gastric noncardia cancer occurred. Compared with nonsmokers, current smokers were at increased risk for ESCC (hazard ratio (HR) = 9.27, 95% confidence interval (CI): 4.04, 21.29), esophageal adenocarcinoma (HR = 3.70, 95% CI: 2.20, 6.22), gastric cardia (HR = 2.86, 95% CI: 1.73, 4.70), and gastric noncardia (HR = 2.04, 95% CI: 1.32, 3.16). Assuming causality, ever smoking had population attributable risks of 77% (95% CI: 0.55, 0.89) for ESCC, 58% (95% CI: 0.38, 0.72) for esophageal adenocarcinoma, 47% (95% CI: 0.27, 0.63) for gastric cardia, and 19% (95% CI: 0.00, 0.37) for gastric noncardia. For drinkers of more than three alcoholic beverages per day, compared with those whose intake was up to one drink per day, the authors found significant associations between alcohol intake and ESCC risk (HR = 4.93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma. JF - American Journal of Epidemiology AU - Freedman, Neal D AU - Abnet, Christian C AU - Leitzmann, Michael F AU - Mouw, Traci AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1424 EP - 1433 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 12 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Alcohol KW - Smoking KW - Etiology KW - Tobacco KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=A+Prospective+Study+of+Tobacco%2C+Alcohol%2C+and+the+Risk+of+Esophageal+and+Gastric+Cancer+Subtypes&rft.au=Freedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-06-01&rft.volume=165&rft.issue=12&rft.spage=1424&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smoking; Alcohol; Etiology; Tobacco; Cancer ER - TY - JOUR T1 - Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine IgE and Airway Hyperreactivity Response to Ovalbumin AN - 19678731; 7421951 AB - These studies were conducted to investigate the role of dermal exposure to perfluorooctanoic acid (PFOA), a known immunosuppressant, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. PFOA has had widespread use as a carpet and fabric protectant. BALB/c mice were exposed dermally, on the dorsal surface of each ear, to concentrations of PFOA ranging from 0.01 to 1.5% (applied dose 0.25-50 mg/kg) for 4 days. In hypersensitivity studies, mice were also ip injected with 7.5 mu g OVA and 2 mg alum on days 1 and 10 and in some studies challenged with 250 mu g OVA by pharyngeal aspiration on days 17 and 26. Following exposure to PFOA, an increase in liver weights and a decrease in thymus and spleen weights and cellularities were observed. Similar immunomodulatory trends were demonstrated in mice coadministered PFOA and OVA. Compared to the OVA alone-exposed animals, an increase in total IgE was demonstrated when mice were coexposed to OVA and concentrations of PFOA ranging from 0.75 to 1.5%, while the OVA-specific IgE response peaked with 0.75% PFOA coexposure (p less than or equal to 0.05). OVA-specific airway hyperreactivity was increased in the 1.0% PFOA coexposed group (p less than or equal to 0.05), with an increased pleiotropic cell response characterized by eosinophilia and mucin production, in animals coexposed to concentrations of PFOA up to 1.0%, as compared to the OVA alone-exposed animals. In a murine model, PFOA was demonstrated to be immunotoxic following dermal exposure, with an enhancement of the hypersensitivity response to OVA, suggesting that PFOA exposure may augment the IgE response to environmental allergens. JF - Toxicological Sciences AU - Fairley, Kimberly J AU - Purdy, Rich AU - Kearns, Shaun AU - Anderson, Stacey E AU - Meade, B J AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505. Baldur Toxicology, N7659 950th Street, River Falls, Wisconsin 54022 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 375 EP - 383 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 97 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts; Immunology Abstracts KW - Ovalbumin KW - Skin KW - Pharynx KW - Thymus KW - Animal models KW - Spleen KW - Asthma KW - perfluorooctanoic acid KW - Ear KW - Immunosuppressive agents KW - Eosinophilia KW - Alum KW - Fabrics KW - Hypersensitivity KW - Aluminum sulfate KW - Carpets KW - Allergens KW - Immunoglobulin E KW - Liver KW - mucin KW - Respiratory tract KW - F 06925:Hypersensitivity KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19678731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Exposure+to+the+Immunosuppresant%2C+Perfluorooctanoic+Acid%2C+Enhances+the+Murine+IgE+and+Airway+Hyperreactivity+Response+to+Ovalbumin&rft.au=Fairley%2C+Kimberly+J%3BPurdy%2C+Rich%3BKearns%2C+Shaun%3BAnderson%2C+Stacey+E%3BMeade%2C+B+J&rft.aulast=Fairley&rft.aufirst=Kimberly&rft.date=2007-06-01&rft.volume=97&rft.issue=2&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ovalbumin; Pharynx; Skin; Thymus; Animal models; Asthma; Spleen; Ear; perfluorooctanoic acid; Eosinophilia; Immunosuppressive agents; Alum; Fabrics; Hypersensitivity; Aluminum sulfate; Carpets; Immunoglobulin E; Allergens; mucin; Liver; Respiratory tract ER - TY - JOUR T1 - Evaluation of the Contact and Respiratory Sensitization Potential of Volatile Organic Compounds Generated by Simulated Indoor Air Chemistry AN - 19667987; 7421949 AB - Up to 60 million people working indoors experience symptoms such as eye, nose and throat irritation, headache, and fatigue. Investigations into these complaints have ascribed the effects to volatile organic compounds (VOCs) emitted from building materials, cleaning formulations, or other consumer products. New compounds can result when the VOCs react with hydroxyl or nitrate radicals or ozone present in indoor environments. Several oxygenated organic compounds, such as glyoxal, methylglyoxal, glycolaldehyde, and diacetyl, have been identified as possible reaction products of indoor environment chemistry. Although research has previously identified diacetyl and glyoxal as sensitizers, additional experiments were conducted in these studies to further classify their sensitization potential. Sensitization potential of these four compounds was assessed using quantitative structure-activity relationship (QSAR) programs. Derek for Windows and National Institute for Occupational Safety and Health logistic regression predicted all compounds to be sensitizers, while TOPKAT 6.2 predicted all compounds except for methylglyoxal. All compounds were tested in a combined irritancy and local lymph node assay (LLNA). All compounds except for glyoxal were found to be irritants and all tested positive in the LLNA with EC3 values ranging from 0.42 to 1.9%. Methylglyoxal significantly increased both the B220 super(+) and IgE super(+)B220 super(+) cell populations in the draining lymph nodes and total serum IgE levels. The four compounds generated by indoor air chemistry were predicted by QSAR and animal modeling to be sensitizers, with the potential for methylglyoxal to induce IgE. The identification of these compounds as sensitizers may help to explain some of the health effects associated with indoor air complaints. JF - Toxicological Sciences AU - Anderson, Stacey E AU - Wells, J R AU - Fedorowicz, Adam AU - Butterworth, Leon F AU - Meade, B J AU - Munson, Albert E AD - National Institute for Occupational Safety and Health, 1095 Willowdale Drive, Morgantown, West Virginia 26505 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 355 EP - 363 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 97 IS - 2 SN - 1096-6080, 1096-6080 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Immunology Abstracts; Pollution Abstracts KW - Nitrate KW - Pharynx KW - Consumer products KW - Eye KW - Occupational safety KW - Pollution effects KW - fatigue KW - Headache KW - glycolaldehyde KW - Consumers KW - Pyruvaldehyde KW - Ozone KW - Fatigue KW - Nitrates KW - Free radicals KW - Local lymph node assay KW - Construction materials KW - Irritation KW - Diacetyl KW - Lymph nodes KW - Immunoglobulin E KW - Atmospheric chemistry KW - volatile organic compounds KW - Nose KW - Organic compounds KW - Indoor environments KW - Structure-activity relationships KW - Volatile organic compounds KW - F 06925:Hypersensitivity KW - X 24490:Other KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19667987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Evaluation+of+the+Contact+and+Respiratory+Sensitization+Potential+of+Volatile+Organic+Compounds+Generated+by+Simulated+Indoor+Air+Chemistry&rft.au=Anderson%2C+Stacey+E%3BWells%2C+J+R%3BFedorowicz%2C+Adam%3BButterworth%2C+Leon+F%3BMeade%2C+B+J%3BMunson%2C+Albert+E&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2007-06-01&rft.volume=97&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Nitrate; Pharynx; Fatigue; Eye; Free radicals; Local lymph node assay; Lymph nodes; Diacetyl; Irritation; Immunoglobulin E; Headache; glycolaldehyde; volatile organic compounds; Consumers; Nose; Organic compounds; Pyruvaldehyde; Structure-activity relationships; Ozone; Nitrates; Consumer products; Occupational safety; Atmospheric chemistry; Construction materials; Pollution effects; Indoor environments; fatigue; Volatile organic compounds ER - TY - JOUR T1 - Assessment of Medical Imaging Systems and Computer Aids: A Tutorial Review AN - 19651422; 8604013 AB - This article reviews the central issues that arise in the assessment of diagnostic imaging and computer-assist modalities. The paradigm of the receiver operating characteristic (ROC) curve - the dependence of the true- positive fraction versus the false-positive fraction as a function of the level of aggressiveness of the reader/radiologist toward a positive call - is essential to this field because diagnostic imaging systems are used in multiple settings, including controlled laboratory studies in which the prevalence of disease is different from that encountered in a study in the field. The sic equation of statistical decision theory is used to display how readers can vary their level of aggressiveness according to this diagnostic context. Most studies of diagnostic modalities in the last 15 years have demonstrated not only a range of levels of reader aggressiveness, but also a range of level of reader performance. These characteristics require a multivariate approach to ROC analysis that accounts for both the variation of case difficulty and the variation of reader skill in a study. The resulting paradigm is called the multiple-reader, multiple-case ROC paradigm. Highlights of historic as well as contemporary work in this field are reviewed. Many practical issues related to study design and resulting statistical power are included, together with recent developments and availability of analytical software. JF - Academic Radiology AU - Wagner, Robert F AU - Metz, Charles E AU - Campbell, Gregory AD - Office of Science and Engineering Laboratories, robert.wagner@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 723 EP - 748 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 6 SN - 1076-6332, 1076-6332 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - ROC analysis KW - Multiple-reader multiple-case (MRMC) ROC analysis KW - Assessment methodologies KW - Computer programs KW - software KW - Statistics KW - Mathematical models KW - Vocalization behavior KW - Reviews KW - Computers KW - imaging KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19651422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+Radiology&rft.atitle=Assessment+of+Medical+Imaging+Systems+and+Computer+Aids%3A+A+Tutorial+Review&rft.au=Wagner%2C+Robert+F%3BMetz%2C+Charles+E%3BCampbell%2C+Gregory&rft.aulast=Wagner&rft.aufirst=Robert&rft.date=2007-06-01&rft.volume=14&rft.issue=6&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Academic+Radiology&rft.issn=10766332&rft_id=info:doi/10.1016%2Fj.acra.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Mathematical models; Statistics; Vocalization behavior; Computers; Reviews; imaging DO - http://dx.doi.org/10.1016/j.acra.2007.03.001 ER - TY - JOUR T1 - Performance Testing of NIOSH Method 5524/ASTM Method D-7049-04, for Determination of Metalworking Fluids AN - 19582899; 8501974 AB - A performance test of NIOSH Method 5524/ASTM Method D-7049-04 for analysis of metalworking fluids (MWF) was conducted. These methods involve determination of the total and extractable weights of MWF samples; extractions are performed using a ternary blend of toluene:dichloromethane:methanol and a binary blend of methanol:water. Six laboratories participated in this study. A preliminary analysis of 20 blank samples was made to familiarize the laboratories with the procedure(s) and to estimate the methods' limits of detection/quantitation (LODs/LOQs). Synthetically generated samples of a semisynthetic MWF aerosol were then collected on tared polytetrafluoroethylene (PTFE) filters and analyzed according to the methods by all participants. Sample masses deposited (~ 400-500 m g) corresponded to amounts expected in an 8-hr shift at the NIOSH recommended exposure levels (REL) of 0.4 mg/m3 (thoracic) and 0.5 mg/m3 (total particulate). The generator output was monitored with a calibrated laser particle counter. One laboratory significantly underreported the sampled masses relative to the other five labs. A follow-up study compared only gravimetric results of this laboratory with those of two other labs. In the preliminary analysis of blanks; the average LOQs were 0.094 mg for the total weight analysis and 0.136 mg for the extracted weight analyses. For the six-lab study, the average LOQs were 0.064 mg for the total weight analyses and 0.067 mg for the extracted weight analyses. Using ASTM conventions, h and k statistics were computed to determine the degree of consistency of each laboratory with the others. One laboratory experienced problems with precision but not bias. The precision estimates for the remaining five labs were not different statistically (a = 0.005) for either the total or extractable weights. For all six labs, the average fraction extracted was >=0.94 (CV = 0.025). Pooled estimates of the total coefficients of variation of analysis were 0.13 for the total weight samples and 0.13 for the extracted weight samples. An overall method bias of -5% was determined by comparing the overall mean concentration reported by the participants to that determined by the particle counter. In the three-lab follow-up study, the nonconsistent lab reported results that were unbiased but statistically less precise than the others; the average LOQ was 0.133 mg for the total weight analyses. It is concluded that aerosolized MWF sampled at concentrations corresponding to either of the NIOSH RELs can generally be shipped unrefrigerated, stored refrigerated up to 7 days, and then analyzed quantitatively and precisely for MWF using the NIOSH/ASTM procedures. JF - Journal of Occupational and Environmental Hygiene AU - Glaser, Robert AU - Kurimo, Robert AU - Shulman, Stanley AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 583 EP - 595 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 8 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Filters KW - Aerosols KW - metal-working fluids KW - Particulates KW - particle counters KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Performance+Testing+of+NIOSH+Method+5524%2FASTM+Method+D-7049-04%2C+for+Determination+of+Metalworking+Fluids&rft.au=Glaser%2C+Robert%3BKurimo%2C+Robert%3BShulman%2C+Stanley&rft.aulast=Glaser&rft.aufirst=Robert&rft.date=2007-06-01&rft.volume=4&rft.issue=8&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701473281 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Filters; Aerosols; metal-working fluids; Particulates; particle counters; Occupational exposure DO - http://dx.doi.org/10.1080/15459620701473281 ER - TY - JOUR T1 - Hexavalent Chromium Exposures and Exposure-Control Technologies in American Enterprise: Results of a NIOSH Field Research Study AN - 19539675; 8501975 AB - The National Institute for Occupational Safety and Health (NIOSH) conducted 21 field surveys in selected industries to characterize workers' exposures to hexavalent chromium-containing airborne particulate and to evaluate existing technologies for controlling these exposures. Hexavalent chromium Cr(VI) is a respiratory irritant and chronic inhalation may cause lung cancer. Primary evaluation methods included collection of full work shift, personal breathing-zone (PBZ) air samples for Cr(VI), measurement of ventilation system parameters, and documentation of processes and work practices. This study emphasized evaluation of engineering exposure control measures, so PBZ exposures were measured on the outside of personal protective equipment, for example, respirators. Field surveys were conducted in two chromium electroplating facilities, including one where full-shift PBZ exposures to Cr(VI) ranged from 3.0 to 16 times the 1 is a subset of g/m3NIOSH recommended exposure limit (REL) despite several engineering controls on the plating tanks. At a painting and coating facility that used Cr(VI)-containing products, full-shift exposures of painters and helpers (2.4 to 55 is a subset of g/m3) exceeded the REL, but LEV effectiveness was limited. Other operations evaluated included welding in construction; metal cutting operations on chromium-containing materials in ship breaking; chromate-paint removal with abrasive blasting; atomized alloy-spray coating; foundry operations; printing; and the manufacture of refractory brick, colored glass, prefabricated concrete products, and treated wood products. NIOSH researchers concluded that, in many of the evaluated processes, Cr(VI) exposures at or below the current NIOSH REL are achievable. However, for some processes, it is unclear whether controlling exposures to this range is consistently achievable without respirator use. Some operations involving the application of coatings and finishes may be among those most difficult to control to this range. Most operations judged to be moderately difficult to control to this range involve joining and cutting metals with relatively high chromium content. Nonetheless, exposures in a wide variety of other processes were judged more easily controllable to the current REL or below, or were found to be minimal, including some operations meeting the general descriptions named above but with different specific operating parameters producing lower Cr(VI) exposures. JF - Journal of Occupational and Environmental Hygiene AU - Blade, L M AU - Yencken, M Story AU - Wallace, M E AU - Catalano, J D AU - Khan, A AU - Topmiller, J L AU - Shulman, S A AU - Martinez, A AU - Crouch, K G AU - Bennett, J S AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 596 EP - 618 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 8 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Ships KW - Inhalation KW - Printing KW - Ventilation KW - Heavy metals KW - Occupational safety KW - Particulates KW - cuttings KW - Concrete KW - Airborne particulates KW - blasting KW - Foundries KW - Air sampling KW - Metal finishing industry KW - Welding KW - Occupational exposure KW - Lung cancer KW - Environmental hygiene KW - Metals KW - Chromium KW - Wood KW - Protective equipment KW - Respirators KW - Technology KW - Coatings KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Hexavalent+Chromium+Exposures+and+Exposure-Control+Technologies+in+American+Enterprise%3A+Results+of+a+NIOSH+Field+Research+Study&rft.au=Blade%2C+L+M%3BYencken%2C+M+Story%3BWallace%2C+M+E%3BCatalano%2C+J+D%3BKhan%2C+A%3BTopmiller%2C+J+L%3BShulman%2C+S+A%3BMartinez%2C+A%3BCrouch%2C+K+G%3BBennett%2C+J+S&rft.aulast=Blade&rft.aufirst=L&rft.date=2007-06-01&rft.volume=4&rft.issue=8&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701463183 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inhalation; Printing; Airborne particulates; Ventilation; Chromium; Heavy metals; Welding; Respirators; Occupational exposure; Environmental hygiene; Lung cancer; Coatings; Ships; Metals; Occupational safety; Wood; Particulates; cuttings; Concrete; Protective equipment; blasting; Foundries; Air sampling; Metal finishing industry; Technology DO - http://dx.doi.org/10.1080/15459620701463183 ER - TY - JOUR T1 - Review of Chamber Design Requirements for Testing of Personal Protective Clothing Ensembles AN - 19539489; 8501972 AB - This review focuses on the physical requirements for conducting ensemble testing and describes the salient issues that organizations involved in the design, test, or certification of personal protective equipment (PPE) and protective clothing ensembles need to consider for strategic planning. Several current and proposed PPE ensemble test practices and standards were identified. The man-in-simulant test (MIST) is the primary procedure used by the military to evaluate clothing ensembles for protection against chemical and biological warfare agents. MIST has been incorporated into the current editions of protective clothing and equipment standards promulgated by the National Fire Protection Association (NFPA). ASTM has recently developed a new test method (ASTM F 2588-06) for MIST evaluation of protective ensembles. Other relevant test methods include those described in International Organization for Standardization (ISO) standards. The primary differences among the test methods were the choice of test challenge material (e.g., sulfur hexafluoride, methyl salicylate, sodium chloride particles, corn oil, fluorophore-impregnated silica) and the exercise protocol for the subject(s). Although ensemble test methods and standards provide detailed descriptions of the test procedures, none give specific requirements for chamber design. A literature survey identified 28 whole-body exposure chambers that have been or could potentially be used for testing protective clothing ensembles using human test subjects. Median chamber size, median floor space, and median volume per subject were calculated from 15 chambers (involving human test subjects), where size information is available. Based on the literature survey of existing chambers and the review of the current and proposed standards and test methods, chamber design requirements will be dictated by the test methods selected. Due to widely different test conditions for aerosol/particulate and vapor ensemble testing, it is unlikely that a single chamber could accommodate all types of ensemble testing. With increasing use of the MIST protocol by NFPA for CBRN certification of structural firefighting gear and protective ensembles for first responders, the need for MIST laboratory capability is clear. However, existing chambers can likely be adapted to accommodate MIST with some modifications. JF - Journal of Occupational and Environmental Hygiene AU - Gao, Pengfei AU - King, William P AU - Shaffer, Ronald AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 562 EP - 571 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 8 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Sulfur KW - Fires KW - Aerosols KW - Mists KW - Particulates KW - Protective equipment KW - corn KW - Design KW - Oil KW - certification KW - International Organization for Standardization KW - Vapors KW - Protective clothing KW - silica KW - Reviews KW - Military KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Review+of+Chamber+Design+Requirements+for+Testing+of+Personal+Protective+Clothing+Ensembles&rft.au=Gao%2C+Pengfei%3BKing%2C+William+P%3BShaffer%2C+Ronald&rft.aulast=Gao&rft.aufirst=Pengfei&rft.date=2007-06-01&rft.volume=4&rft.issue=8&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701448416 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sulfur; Fires; Aerosols; Mists; Particulates; Protective equipment; corn; Design; Oil; International Organization for Standardization; certification; Protective clothing; Vapors; Reviews; silica; Military; International standardization DO - http://dx.doi.org/10.1080/15459620701448416 ER - TY - JOUR T1 - Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene AN - 19527221; 8029528 AB - Adverse events associated with the use of live smallpox vaccines have led to the development of a new generation of attenuated smallpox vaccines that are prepared in cultured cells as alternatives. The inability to conduct direct clinical evaluation of their efficacy in humans demands that licensure be based on animal studies and exhaustive evaluation of their in vitro properties. One of the most important characteristics of live viral vaccines is their genetic stability, including reversion of the vaccine strain to more virulent forms, recombination with other viral sequences to produce potentially pathogenic viruses, and genetic drift that can result in decrease of immunogenicity and efficacy. To study genetic stability of an immunoessential vaccinia virus gene in a new generation smallpox vaccine, an advanced oligonucleotide microchip was developed and used to assay for mutations that could emerge in B5R gene, a vaccinia virus gene encoding for a protein that contains very important neutralizing epitopes. This microarray contained overlapping oligonucleotides covering the B5R gene of modified vaccinia virus Ankara (MVA), a well-studied candidate smallpox vaccine. The microarray assay was shown to be able to detect even a single point mutation, and to differentiate between vaccinia strains. At the same time, it could detect newly emerged mutations in clones of vaccinia strains. In the work described here, it was shown that MVA B5R gene was stable after 34 passages in Vero and MRC-5 cells that were proposed for use as cell substrates for vaccine manufacture. Potentially, the proposed method could be used as an identity test and could be extended for the entire viral genome and used to monitor consistency of vaccine production. J. Med. Virol. 79: 791-802, 2007. JF - Journal of Medical Virology AU - Laassri, Majid AU - Meseda, Clement A AU - Williams, Ollie AU - Merchlinsky, Michael AU - Weir, Jerry P AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, Maryland 20852, majid.laassri@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 791 EP - 802 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 79 IS - 6 SN - 0146-6615, 0146-6615 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Vaccinia KW - Point mutation KW - Reversion KW - Oligonucleotides KW - Smallpox KW - Recombination KW - Vaccinia virus KW - Immunogenicity KW - microchips KW - Vaccines KW - Genetic drift KW - Epitopes KW - V 22300:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19527221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Virology&rft.atitle=Microarray+assay+for+evaluation+of+the+genetic+stability+of+modified+vaccinia+virus+Ankara+B5R+gene&rft.au=Laassri%2C+Majid%3BMeseda%2C+Clement+A%3BWilliams%2C+Ollie%3BMerchlinsky%2C+Michael%3BWeir%2C+Jerry+P%3BChumakov%2C+Konstantin&rft.aulast=Laassri&rft.aufirst=Majid&rft.date=2007-06-01&rft.volume=79&rft.issue=6&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Virology&rft.issn=01466615&rft_id=info:doi/10.1002%2Fjmv.20889 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Smallpox; Recombination; Immunogenicity; Vaccinia; Point mutation; microchips; Reversion; Vaccines; Genetic drift; Oligonucleotides; Epitopes; Vaccinia virus DO - http://dx.doi.org/10.1002/jmv.20889 ER - TY - JOUR T1 - Common variants in genes that mediate immunity and risk of multiple myeloma AN - 19521735; 8079427 AB - Multiple myeloma (MM) is a B-cell malignancy characterized by aberrant immune function. Using genomic DNA extracted from 127 MM cases aged 21-84 years and 545 population-based controls, we examined the risk of MM associated with 82 common variants in 45 genes that mediate immunity among women of European American descent. Genotyping was determined using validated and optimized TaqMan assays. We estimated haplotype frequencies from unphased genotype data for 20 of these genes using the expectation-maximization progressive insertion algorithm. Compared with controls, MM risk was positively associated with homozygotes of single loci, IL4R (-28120T, rs2107356) and FCGR2A (-120G, rs1801274) (OR = 1.91, 95% CI 1.08-3.38 and 1.95, 95% CI 1.06-3.60, respectively). For genes in which linkage disequilibrium was observed between multiple loci, MM risk was positively associated with the haplotype block covering part of the LTA*TNF complex (LTA -82C/-90G *TNF -1036C/-487G/-417G, OR = 1.63, 95% CI 1.02-2.16) compared with the most frequently occurring haplotype observed among controls (LTA -82A/-90A *TNF -1036C/-487G/-417G). Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM. JF - International Journal of Cancer AU - Brown, Elizabeth E AU - Lan, Qing AU - Zheng, Tongzhang AU - Zhang, Yawei AU - Wang, Sophia S AU - Hoar-Zahm, Shelia AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Baris, Dalsu AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, elbrown@uab.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2715 EP - 2722 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 12 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts; Immunology Abstracts KW - Data processing KW - double prime Fc receptors KW - multiple myeloma KW - Lymphocytes B KW - Genotyping KW - Tumor necrosis factor KW - Algorithms KW - haplotypes KW - Immunity KW - Genotypes KW - Interleukin 4 receptors KW - Cancer KW - Homozygotes KW - Linkage disequilibrium KW - Malignancy KW - Multiple myeloma KW - Haplotypes KW - Insertion KW - DNA KW - Immune response KW - genomics KW - G 07720:Immunogenetics KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Common+variants+in+genes+that+mediate+immunity+and+risk+of+multiple+myeloma&rft.au=Brown%2C+Elizabeth+E%3BLan%2C+Qing%3BZheng%2C+Tongzhang%3BZhang%2C+Yawei%3BWang%2C+Sophia+S%3BHoar-Zahm%2C+Shelia%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BBaris%2C+Dalsu&rft.aulast=Brown&rft.aufirst=Elizabeth&rft.date=2007-06-01&rft.volume=120&rft.issue=12&rft.spage=2715&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; double prime Fc receptors; Lymphocytes B; Tumor necrosis factor; Genotyping; Algorithms; Genotypes; Immunity; Interleukin 4 receptors; Homozygotes; Linkage disequilibrium; Malignancy; Haplotypes; Multiple myeloma; Insertion; genomics; Immune response; multiple myeloma; DNA; haplotypes; Cancer DO - http://dx.doi.org/10.1002/ijc.22618 ER - TY - JOUR T1 - Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants AN - 1709167274; 15622702 AB - Single low and high doses of several compounds with known renal toxic effects (para-aminophenol, puromycin aminonucleoside, sodium chromate, and hexachlorobutadiene,) or known liver toxic effects (galactosamine, allyl alcohol, and thioacetamide) were administered to male Wistar rats in groups of 4 or 8 for each compound. Predose urine samples (Day 0) and samples from post-dosing (Days 1-4) were collected for each rat and monitored by 1D super(1)H NMR. Principal component analysis (PCA) of the NMR spectra was used to investigate differences between dose levels for each compound individually. The findings from PCA at both dose levels for each compound were examined in the context of the corresponding clinical chemistry and pathology data collected during the study. The PCA clustering of NMR spectra from rats dosed with each individual compound were shown to be associated with the measured levels of creatinine, BUN, AST, ALT and histopathology findings. Finally, scaled-to-maximum, aligned, and reduced trajectories (SMART) analysis was applied to compare the temporal metabolic trajectories obtained for each animal at each dose level of the administered compounds. By day 4, the SMART trajectories for allyl alcohol and hexachlorobutadiene had returned to predose levels indicating a recovery response, however, the high dose SMART trajectories for para-aminophenol, puromycin aminonucleoside, sodium chromate, and galactosamine did not appear to return to predose levels indicating a prolonged toxic effect. JF - Metabolomics AU - Schnackenberg, Laura K AU - Dragan, Yvonne P AU - Reily, Michael D AU - Robertson, Donald G AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, 72079-9502, USA, richard.beger@fda.hhs.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 87 EP - 100 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 3 IS - 2 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - sodium chromate KW - Data processing KW - Toxicants KW - Thioacetamide KW - Creatinine KW - Urine KW - Principal components analysis KW - allyl alcohol KW - Liver KW - Kidney KW - N.M.R. KW - metabolomics KW - puromycin KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709167274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Evaluation+of+NMR+spectral+data+of+urine+in+conjunction+with+measured+clinical+chemistry+and+histopathology+parameters+to+assess+the+effects+of+liver+and+kidney+toxicants&rft.au=Schnackenberg%2C+Laura+K%3BDragan%2C+Yvonne+P%3BReily%2C+Michael+D%3BRobertson%2C+Donald+G%3BBeger%2C+Richard+D&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2007-06-01&rft.volume=3&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-006-0046-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - sodium chromate; Data processing; Toxicants; Thioacetamide; Creatinine; Urine; Principal components analysis; allyl alcohol; Kidney; Liver; N.M.R.; metabolomics; puromycin DO - http://dx.doi.org/10.1007/s11306-006-0046-y ER - TY - JOUR T1 - Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System. AN - 70514025; 17502736 AB - The risk of nephrolithiasis associated with atazanavir is not well characterized. The US Food and Drug Administration's Adverse Event Reporting System was searched for reports of nephrolithiasis in HIV-infected patients taking an atazanavir-based regimen. Thirty cases were identified. Many patients required hospitalization for management, including lithotripsy, ureteral stent insertion, or endoscopic stone removal. Some cases of nephrolithiasis resulted in atazanavir discontinuation. Healthcare professionals and patients should be informed that nephrolithiasis is a possible adverse event with atazanavir. JF - AIDS (London, England) AU - Chan-Tack, Kirk M AU - Truffa, Melissa M AU - Struble, Kimberly A AU - Birnkrant, Debra B AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2007/05/31/ PY - 2007 DA - 2007 May 31 SP - 1215 EP - 1218 VL - 21 IS - 9 SN - 0269-9370, 0269-9370 KW - HIV Protease Inhibitors KW - 0 KW - Oligopeptides KW - Organophosphonates KW - Pyridines KW - Reverse Transcriptase Inhibitors KW - Atazanavir Sulfate KW - 4MT4VIE29P KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Organophosphonates -- therapeutic use KW - Humans KW - Adenine -- therapeutic use KW - Drug Therapy, Combination KW - Ritonavir -- therapeutic use KW - Hospitalization KW - Adverse Drug Reaction Reporting Systems KW - Adult KW - Middle Aged KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - United States -- epidemiology KW - Adenine -- analogs & derivatives KW - Female KW - Male KW - Nephrolithiasis -- chemically induced KW - Oligopeptides -- therapeutic use KW - HIV Infections -- drug therapy KW - Pyridines -- therapeutic use KW - HIV Protease Inhibitors -- therapeutic use KW - Oligopeptides -- adverse effects KW - Nephrolithiasis -- epidemiology KW - HIV Protease Inhibitors -- adverse effects KW - Pyridines -- adverse effects KW - Nephrolithiasis -- surgery KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70514025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Atazanavir-associated+nephrolithiasis%3A+cases+from+the+US+Food+and+Drug+Administration%27s+Adverse+Event+Reporting+System.&rft.au=Chan-Tack%2C+Kirk+M%3BTruffa%2C+Melissa+M%3BStruble%2C+Kimberly+A%3BBirnkrant%2C+Debra+B&rft.aulast=Chan-Tack&rft.aufirst=Kirk&rft.date=2007-05-31&rft.volume=21&rft.issue=9&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-06 N1 - Date created - 2007-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differentiation of Enterobacter sakazakii from closely related Enterobacter and Citrobacter species using fatty acid profiles. AN - 70527086; 17472390 AB - Capillary gas chromatography with flame ionization detection (GC-FID) was used to determine the cellular fatty acid (CFA) profiles of 134 Enterobacter sakazakii strains, and these were compared to the CFA profiles of other closely related Enterobacter and Citrobacter species. For GC-FID analysis, whole cell fatty acid methyl esters (FAMEs) from cells cultured on brain heart infusion (BHI) agar at 37 degrees C for 24 h were obtained by saponification, methylation, and extraction into hexane/methyl tert-butyl ether. A database for E. sakazakii was prepared using fatty acid profiles from the 134 strains. Major fatty acids of E. sakazakii strains evaluated in this study were straight-chain 12:0, 14:0, and 16:0, unsaturated 18:1 omega7c, and 17:0 omegacyclo 7-8. Principal component analysis (PCA) based on CFA profiles for E. sakazakii strains shows separation of E. sakazakii subgroups A and B. The CFA profiles for E. sakazakii and Enterobacter cloacae show that there are several fatty acids, 14:0, 17:0 omegacyclo 7-8, 18:1 omega7c, and summed 16:1 omega6c/16:1 omega7c, that differ significantly between these two species. A PCA model based on CFA profiles for E. sakazakii strains clearly shows separation of E. sakazakii from closely related Enterobacter and Citrobacter species. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by a rapid GC-FID method can provide a sensitive procedure for the identification of this organism, and this analytical method provides a confirmatory procedure for the differentiation of E. sakazakii strains from closely related Enterobacter and Citrobacter species. JF - Journal of agricultural and food chemistry AU - Whittaker, Paul AU - Keys, Christine E AU - Brown, Eric W AU - Fry, Frederick S AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740-3835, USA. paul.whittaker@fda.hhs.gov Y1 - 2007/05/30/ PY - 2007 DA - 2007 May 30 SP - 4617 EP - 4623 VL - 55 IS - 11 SN - 0021-8561, 0021-8561 KW - Fatty Acids KW - 0 KW - Index Medicus KW - Food Microbiology KW - Enterobacteriaceae Infections -- microbiology KW - Chromatography, Gas KW - Humans KW - Cronobacter sakazakii -- classification KW - Cronobacter sakazakii -- metabolism KW - Citrobacter -- metabolism KW - Citrobacter -- classification KW - Fatty Acids -- analysis KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70527086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Differentiation+of+Enterobacter+sakazakii+from+closely+related+Enterobacter+and+Citrobacter+species+using+fatty+acid+profiles.&rft.au=Whittaker%2C+Paul%3BKeys%2C+Christine+E%3BBrown%2C+Eric+W%3BFry%2C+Frederick+S&rft.aulast=Whittaker&rft.aufirst=Paul&rft.date=2007-05-30&rft.volume=55&rft.issue=11&rft.spage=4617&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interrogating genomic diversity of E. coli O157:H7 using DNA tiling arrays AN - 19737191; 7476265 AB - Here, we describe a novel microarray-based approach for investigating the genomic diversity of Escherichia coli O157:H7 in a semi-high throughput manner using a high density, oligonucleotide-based microarray. This microarray, designed to detect polymorphisms at each of 60,000 base-pair (bp) positions within an E. coli genome, is composed of overlapping 29-mer oligonucleotides specific for 60 equally spaced, 1000-bp loci of the E. coli O157:H7 strain EDL933 chromosome. By use of a novel 12-well microarray that permitted the simultaneous investigation of 12 strains, the genomes of 44 individual isolates of E. coli O157:H7 were interrogated. These analyses revealed more than 150 single nucleotide polymorphisms (SNPs) and several deletions and amplifications in the test strains. Pyrosequencing was used to confirm the usefulness of the novel SNPs by determining their allelic frequency among a collection of diverse isolates of E. coli O157:H7. The tiling DNA microarray system would be useful for the tracking and identification of individual strains of E. coli O157:H7 needed for forensic investigations. JF - Forensic Science International AU - Jackson, SA AU - Mammel, M K AU - Patel, IR AU - Mays, T AU - Albert, T J AU - LeClerc, JE AU - Cebula, T A AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA, Thomas.Cebula@fda.hhs.gov Y1 - 2007/05/24/ PY - 2007 DA - 2007 May 24 SP - 183 EP - 199 VL - 168 IS - 2-3 SN - 0379-0738, 0379-0738 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Gene deletion KW - Chromosomes KW - Single-nucleotide polymorphism KW - Escherichia coli KW - Forensic science KW - genomics KW - DNA microarrays KW - Oligonucleotides KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19737191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+Science+International&rft.atitle=Interrogating+genomic+diversity+of+E.+coli+O157%3AH7+using+DNA+tiling+arrays&rft.au=Jackson%2C+SA%3BMammel%2C+M+K%3BPatel%2C+IR%3BMays%2C+T%3BAlbert%2C+T+J%3BLeClerc%2C+JE%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=SA&rft.date=2007-05-24&rft.volume=168&rft.issue=2-3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Forensic+Science+International&rft.issn=03790738&rft_id=info:doi/10.1016%2Fj.forsciint.2006.06.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Chromosomes; Gene deletion; Single-nucleotide polymorphism; Forensic science; genomics; Oligonucleotides; DNA microarrays; Escherichia coli DO - http://dx.doi.org/10.1016/j.forsciint.2006.06.079 ER - TY - JOUR T1 - Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samples AN - 19668660; 7430235 AB - Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus type-1 (HIV-1) are transfusion-transmitted human pathogens that have a major impact on blood safety and public health worldwide. We developed a microarray multiplex assay for the simultaneous detection and discrimination of these three viruses. The microarray consists of 16 oligonucleotide probes, immobilized on a silylated glass slide. Amplicons from multiplex PCR were labeled with Cy-5 and hybridized to the microarray. The assay detected 1 International Unit (IU), 10IU, 20IU of HBV, HCV, and HIV-1, respectively, in a single multiplex reaction. The assay also detected and discriminated the presence of two or three of these viruses in a single sample. Our data represent a proof-of-concept for the possible use of highly sensitive multiplex microarray assay to screen and confirm the presence of these viruses in blood donors and patients. JF - Biochemical and Biophysical Research Communications AU - Hsia, C C AU - Chizhikov, V E AU - Yang, A X AU - Selvapandiyan, A AU - Hewlett, I AU - Duncan, R AU - Puri, R K AU - Nakhasi, H L AU - Kaplan, G G AD - Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA, chuchieh.hsia@fda.hhs.gov Y1 - 2007/05/18/ PY - 2007 DA - 2007 May 18 SP - 1017 EP - 1023 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 356 IS - 4 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Blood donors KW - Hepatitis B virus KW - Immunodeficiency KW - Pathogens KW - Oligonucleotides KW - Public health KW - Hepatitis C virus KW - Human immunodeficiency virus 1 KW - Hepatitis B KW - Polymerase chain reaction KW - Hepatitis C KW - V 22360:AIDS and HIV KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Microarray+multiplex+assay+for+the+simultaneous+detection+and+discrimination+of+hepatitis+B%2C+hepatitis+C%2C+and+human+immunodeficiency+type-1+viruses+in+human+blood+samples&rft.au=Hsia%2C+C+C%3BChizhikov%2C+V+E%3BYang%2C+A+X%3BSelvapandiyan%2C+A%3BHewlett%2C+I%3BDuncan%2C+R%3BPuri%2C+R+K%3BNakhasi%2C+H+L%3BKaplan%2C+G+G&rft.aulast=Hsia&rft.aufirst=C&rft.date=2007-05-18&rft.volume=356&rft.issue=4&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.03.087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hepatitis B virus; Hepatitis C virus; Human immunodeficiency virus 1; Public health; Immunodeficiency; Pathogens; Oligonucleotides; Hepatitis C; Hepatitis B; Blood donors; Polymerase chain reaction DO - http://dx.doi.org/10.1016/j.bbrc.2007.03.087 ER - TY - JOUR T1 - Incorporation of a lambda phage recombination system and EGFP detection to simplify mutagenesis of Herpes simplex virus bacterial artificial chromosomes. AN - 70552924; 17501993 AB - Targeted mutagenesis of the herpesvirus genomes has been facilitated by the use of bacterial artificial chromosome (BAC) technology. Such modified genomes have potential uses in understanding viral pathogenesis, gene identification and characterization, and the development of new viral vectors and vaccines. We have previously described the construction of a herpes simplex virus 2 (HSV-2) BAC and the use of an allele replacement strategy to construct HSV-2 recombinants. While the BAC mutagenesis procedure is a powerful method to generate HSV-2 recombinants, particularly in the absence of selective marker in eukaryotic culture, the mutagenesis procedure is still difficult and cumbersome. Here we describe the incorporation of a phage lambda recombination system into an allele replacement vector. This strategy enables any DNA fragment containing the phage attL recombination sites to be efficiently inserted into the attR sites of the allele replacement vector using phage lambda clonase. We also describe how the incorporation of EGFP into the allele replacement vector can facilitate the selection of the desired cross-over recombinant BACs when the allele replacement reaction is a viral gene deletion. Finally, we incorporate the lambda phage recombination sites directly into an HSV-2 BAC vector for direct recombination of gene cassettes using the phage lambda clonase-driven recombination reaction. Together, these improvements to the techniques of HSV BAC mutagenesis will facilitate the construction of recombinant herpes simplex viruses and viral vectors. JF - BMC biotechnology AU - Schmeisser, Falko AU - Weir, Jerry P AD - Laboratory of DNA Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. falko.schmeisser@fda.hhs.gov Y1 - 2007/05/14/ PY - 2007 DA - 2007 May 14 SP - 22 VL - 7 KW - Recombinant Fusion Proteins KW - 0 KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Recombination, Genetic -- genetics KW - Transfection -- methods KW - Bacteriophage lambda -- genetics KW - Mutagenesis, Site-Directed -- methods KW - Simplexvirus -- genetics KW - Chromosomes, Artificial, Bacterial -- genetics KW - Genetic Vectors -- genetics KW - Green Fluorescent Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70552924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+biotechnology&rft.atitle=Incorporation+of+a+lambda+phage+recombination+system+and+EGFP+detection+to+simplify+mutagenesis+of+Herpes+simplex+virus+bacterial+artificial+chromosomes.&rft.au=Schmeisser%2C+Falko%3BWeir%2C+Jerry+P&rft.aulast=Schmeisser&rft.aufirst=Falko&rft.date=2007-05-14&rft.volume=7&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=BMC+biotechnology&rft.issn=1472-6750&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gene Ther. 2006 Apr;13(8):705-14 [16421599] J Gen Virol. 2006 Mar;87(Pt 3):509-17 [16476972] Trends Genet. 2000 Jun;16(6):254-9 [10827452] J Virol. 2000 Aug;74(15):6964-74 [10888635] J Virol. 2000 Dec;74(23):11088-98 [11070004] J Virol. 2002 Mar;76(5):2316-28 [11836410] Trends Microbiol. 2002 Jul;10(7):318-24 [12110210] J Virol. 2003 Jan;77(2):1382-91 [12502854] Virology. 2003 Mar 1;307(1):164-77 [12667824] J Virol. 2003 May;77(9):5073-83 [12692210] J Gen Virol. 2003 Dec;84(Pt 12):3393-403 [14645920] J Virol. 2004 Jan;78(1):539-43 [14671136] Virology. 2004 Jan 5;318(1):420-8 [14972567] Methods Mol Biol. 2004;256:281-302 [15024173] J Virol. 1988 May;62(5):1486-94 [2833603] J Mol Biol. 1992 Aug 5;226(3):735-45 [1324324] Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8794-7 [1528894] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10847-51 [1438287] Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14759-63 [9405686] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8245-50 [9653172] J Virol. 1999 Aug;73(8):6405-14 [10400733] Methods Enzymol. 1999;306:337-52 [10432464] J Virol. 1999 Oct;73(10):8320-9 [10482582] Gene Ther. 1999 May;6(5):922-30 [10505118] Nucleic Acids Res. 2005;33(4):e36 [15731329] J Virol. 2005 Apr;79(7):4066-79 [15767408] J Gen Virol. 2005 Apr;86(Pt 4):907-17 [15784885] Cancer Res. 2005 Dec 1;65(23):10663-8 [16322208] J Virol Methods. 2006 Aug;135(2):197-206 [16647145] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tau overexpression in transgenic mice induces glycogen synthase kinase 3 beta and beta -catenin phosphorylation AN - 19879572; 7497494 AB - The abnormal phosphorylations of tau, GSK3 beta , and beta -catenin have been shown to perform a crucial function in the neuropathology of Alzheimer's disease (AD). The primary objective of the current study was to determine the manner in which overexpressed htau23 interacts and regulates the behavior and phosphorylation characteristics of tau, GSK3 beta , and beta -catenin. In order to accomplish this, transgenic mice expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE/htau23) were created. Transgenic mice evidenced the following: (i) tendency toward memory impairments at later stages, (ii) dramatic overexpression of the tau transgene, coupled with increased tau phosphorylation and paired helical filaments (PHFs), (iii) high levels of GSK3 beta phosphorylation with advanced age, resulting in increases in the phosphorylations of tau and beta -catenin, (iv) an inhibitory effect of lithium on the phosphorylations of tau, GSK3 beta , and beta -catenin, but not in the non-transgenic littermate group. Therefore, the overexpression of NSE/htau23 in the brains of transgenic mice induces abnormal phosphorylations of tau, GSK3 beta , and beta -catenin, which are ultimately linked to neuronal degeneration in cases of AD. These transgenic mice are expected to prove useful for the development of new drugs for the treatment of AD. JF - Neuroscience AU - Shim, S B AU - Lim, HJ AU - Chae, K R AU - Kim, C K AU - Hwang, D Y AU - Jee, S W AU - Lee, SH AU - Sin, J S AU - Leem, Y H AU - Cho, J S AU - Lee, H H AU - Choi, SY AU - Kim, Y K AD - Korea FDA, National Institute of Toxicological Research, 5 Nokbun-dong Eunpyung-ku, Seoul 122-704, Korea, kimyongkyu@hanmail.net Y1 - 2007/05/11/ PY - 2007 DA - 2007 May 11 SP - 730 EP - 740 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 146 IS - 2 SN - 0306-4522, 0306-4522 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Age KW - Alzheimer's disease KW - Brain KW - Drug development KW - Glycogen synthase kinase 3 KW - Transgenic mice KW - Neurodegenerative diseases KW - Memory KW - Nervous system KW - catenin KW - Phosphorylation KW - Tau protein KW - Degeneration KW - Phosphopyruvate hydratase KW - Filaments KW - Lithium KW - Neuropathology KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19879572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Tau+overexpression+in+transgenic+mice+induces+glycogen+synthase+kinase+3+beta+and+beta+-catenin+phosphorylation&rft.au=Shim%2C+S+B%3BLim%2C+HJ%3BChae%2C+K+R%3BKim%2C+C+K%3BHwang%2C+D+Y%3BJee%2C+S+W%3BLee%2C+SH%3BSin%2C+J+S%3BLeem%2C+Y+H%3BCho%2C+J+S%3BLee%2C+H+H%3BChoi%2C+SY%3BKim%2C+Y+K&rft.aulast=Shim&rft.aufirst=S&rft.date=2007-05-11&rft.volume=146&rft.issue=2&rft.spage=730&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2007.01.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Alzheimer's disease; Brain; Drug development; Glycogen synthase kinase 3; Transgenic mice; Neurodegenerative diseases; Nervous system; Memory; catenin; Phosphorylation; Tau protein; Degeneration; Phosphopyruvate hydratase; Filaments; Neuropathology; Lithium DO - http://dx.doi.org/10.1016/j.neuroscience.2007.01.041 ER - TY - CPAPER T1 - Night Driving Performance in the National Advanced Driving Simulator vs. Clinical Tests of Vision T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636289; 4567856 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Drum, B A AU - Rorer, E M AU - Calogero, D Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Vision KW - Simulators KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Night+Driving+Performance+in+the+National+Advanced+Driving+Simulator+vs.+Clinical+Tests+of+Vision&rft.au=Drum%2C+B+A%3BRorer%2C+E+M%3BCalogero%2C+D&rft.aulast=Drum&rft.aufirst=B&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Rapid gas chromatography/mass spectrometry determination and confirmation of patulin in apple juice. AN - 70638920; 17580643 AB - A gas chromatography/mass spectrometry (GC/MS) method was developed for the quantitative determination and confirmation of patulin extracted from apple juice. Juice is alkalized and extracted with ethyl acetate-hexane, a portion concentrated under N2, then resolubilized in acetonitrile for simple derivatization with bis(trimethylsilyl)trifluoracetamide. Patulin was determined by GC/MS using an electron-impact source and selected ion monitoring of characteristic ions. Spike levels of 20-100 microg/L gave an average recovery of 86%, and 6 ions of sample and standard spectra matched within 10% absolute for confirmation. The limits of quantitation and detection were 10 and 3 microg/L, respectively. JF - Journal of AOAC International AU - Marks, Heidi S AD - U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021, USA. heidi.marks@fda.hhs.gov PY - 2007 SP - 879 EP - 883 VL - 90 IS - 3 SN - 1060-3271, 1060-3271 KW - Ions KW - 0 KW - Mycotoxins KW - Patulin KW - 95X2BV4W8R KW - Index Medicus KW - Mass Spectrometry KW - Beverages KW - Reproducibility of Results KW - Food Contamination KW - Malus KW - Calibration KW - Time Factors KW - Mycotoxins -- analysis KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Chemistry Techniques, Analytical -- methods KW - Patulin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70638920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Rapid+gas+chromatography%2Fmass+spectrometry+determination+and+confirmation+of+patulin+in+apple+juice.&rft.au=Marks%2C+Heidi+S&rft.aulast=Marks&rft.aufirst=Heidi&rft.date=2007-05-01&rft.volume=90&rft.issue=3&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-20 N1 - Date created - 2007-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Respirator donning in post-hurricane New Orleans. AN - 70601289; 17553247 AB - We evaluated correctness of N95 filtering facepiece respirator donning by the public in post-hurricane New Orleans, where respirators were recommended for mold remediation. We randomly selected, interviewed, and observed 538 participants, using multiple logistic regression for analysis. Only 129 (24%) participants demonstrated proper donning. Errors included nose clip not tightened (71%) and straps incorrectly placed (52%); 22% put on the respirator upside down. Factors independently associated with proper donning were as follows: ever having used a mask or respirator (odds ratio [OR] 5.28; 95% confidence interval [CI], 1.79-22.64); ever having had a respirator fit test (OR 4.40; 95% CI, 2.52-7.81); being male (OR 2.44; 95% CI, 1.50-4.03); Caucasian race (OR 2.09; 95% CI, 1.32-3.33); having a certified respirator (OR 1.99, 95% CI, 1.20-3.28); and having participated in mold clean-up (OR 1.82; 95% CI,1.00-3.41). Interventions to improve respirator donning should be considered in planning for influenza epidemics and disasters. JF - Emerging infectious diseases AU - Cummings, Kristin J AU - Cox-Ganser, Jean AU - Riggs, Margaret A AU - Edwards, Nicole AU - Kreiss, Kathleen AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 700 EP - 707 VL - 13 IS - 5 SN - 1080-6040, 1080-6040 KW - Index Medicus KW - Cross-Sectional Studies KW - Equipment Failure Analysis KW - Mycoses -- prevention & control KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Data Collection KW - Louisiana KW - Male KW - Female KW - Respiratory Protective Devices -- utilization KW - Inhalation Exposure -- prevention & control KW - Disasters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70601289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+infectious+diseases&rft.atitle=Respirator+donning+in+post-hurricane+New+Orleans.&rft.au=Cummings%2C+Kristin+J%3BCox-Ganser%2C+Jean%3BRiggs%2C+Margaret+A%3BEdwards%2C+Nicole%3BKreiss%2C+Kathleen&rft.aulast=Cummings&rft.aufirst=Kristin&rft.date=2007-05-01&rft.volume=13&rft.issue=5&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Emerging+infectious+diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Occup Environ Hyg. 1999 Dec;14(12):827-37 [10633954] Arch Environ Occup Health. 2006 May-Jun;61(3):101-8 [17672351] Clin Infect Dis. 2003 Oct 15;37(8):1094-101 [14523774] J Occup Environ Hyg. 2004 Apr;1(4):262-71 [15204866] J Formos Med Assoc. 2004 Aug;103(8):624-8 [15340662] Proc Soc Exp Biol Med. 1966 Jul;122(3):800-4 [5918954] J Exp Med. 1967 Mar 1;125(3):479-88 [6016901] Am J Epidemiol. 1979 Jul;110(1):1-6 [463858] Am Ind Hyg Assoc J. 1984 Jan;45(1):63-6 [6702601] Am Ind Hyg Assoc J. 1988 Apr;49(4):199-204 [3287880] Infect Control Hosp Epidemiol. 1996 Oct;17(10):636-40 [8899436] J Med Assoc Thai. 2004 Oct;87(10):1182-7 [15560695] Int J Tuberc Lung Dis. 2005 May;9(5):545-9 [15875927] J Occup Environ Hyg. 2005 Aug;2(8):391-99 [16080261] MMWR Recomm Rep. 2005 Dec 30;54(RR-17):1-141 [16382216] MMWR Morb Mortal Wkly Rep. 2006 Jan 20;55(2):41-4 [16424858] Emerg Infect Dis. 2006 Jan;12(1):88-94 [16494723] MMWR Recomm Rep. 2006 Jun 9;55(RR-8):1-27 [16760892] Emerg Infect Dis. 2006 Nov;12(11):1657-62 [17283614] Infect Control Hosp Epidemiol. 2000 Jan;21(1):28-32 [10656351] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease. AN - 70532491; 17439248 AB - Recent evidence suggests that a deficiency in one or more hepatoprotective regulatory mechanisms may contribute to determining susceptibility in drug-induced liver disease. In the present study, we investigated the role of interleukin (IL)-13 in acetaminophen (APAP)-induced liver disease (AILD). Following APAP (200 mg/kg) administration to male C57BL/6 wild-type (WT) mice, hepatotoxicity developed up to 24 h post-APAP, with a concomitant increase in serum IL-13 concentration. Pretreatment of these mice with an IL-13-neutralizing antibody exacerbated liver injury, as did APAP administration to IL-13 knockout (KO) mice in comparison to WT mice. No difference was observed in either overall APAP-protein adduct formation or liver glutathione levels between KO and WT mice following APAP administration, suggesting that the increased susceptibility of IL-13 KO mice to AILD was not due to enhanced APAP bioactivation but rather injurious downstream events. In this regard, multiplex antibody arrays were used to identify potential IL-13-regulated biomarkers, including various cytokines and chemokines, as well as nitric oxide (NO), associated with AILD that were present at higher concentrations in the sera of APAP-treated IL-13 KO mice than in WT mice. Subsequent inhibition studies determined interferon-gamma, NO, neutrophils, natural killer cells, and natural killer cells with T-cell receptors had pathologic roles in AILD in IL-13 KO mice. Taken together, these results suggest that IL-13 is a critical hepatoprotective factor modulating the susceptibility to AILD and may provide hepatoprotection, in part, by down-regulating protoxicant factors and cells associated with the innate immune system. JF - Chemical research in toxicology AU - Yee, Steven B AU - Bourdi, Mohammed AU - Masson, Mary Jane AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. yees@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 734 EP - 744 VL - 20 IS - 5 SN - 0893-228X, 0893-228X KW - Analgesics, Non-Narcotic KW - 0 KW - Antibodies, Blocking KW - Biomarkers KW - Interleukin-13 KW - Acetaminophen KW - 362O9ITL9D KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Neutrophils -- pathology KW - Liver -- pathology KW - Gene Silencing KW - Antibodies, Blocking -- pharmacology KW - Glutathione -- metabolism KW - Disease Models, Animal KW - Liver -- metabolism KW - Mice KW - Mice, Knockout KW - Neutrophils -- metabolism KW - Neutrophils -- drug effects KW - Alanine Transaminase -- blood KW - Liver -- drug effects KW - Mice, Inbred C57BL KW - Drug Synergism KW - Biomarkers -- blood KW - Male KW - Interleukin-13 -- immunology KW - Interleukin-13 -- blood KW - Chemical and Drug Induced Liver Injury -- blood KW - Chemical and Drug Induced Liver Injury -- prevention & control KW - Interleukin-13 -- deficiency KW - Chemical and Drug Induced Liver Injury -- pathology KW - Analgesics, Non-Narcotic -- toxicity KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity KW - Analgesics, Non-Narcotic -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70532491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Hepatoprotective+role+of+endogenous+interleukin-13+in+a+murine+model+of+acetaminophen-induced+liver+disease.&rft.au=Yee%2C+Steven+B%3BBourdi%2C+Mohammed%3BMasson%2C+Mary+Jane%3BPohl%2C+Lance+R&rft.aulast=Yee&rft.aufirst=Steven&rft.date=2007-05-01&rft.volume=20&rft.issue=5&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-05 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA drug approval summary: panitumumab (Vectibix). AN - 70518862; 17522246 AB - On September 27, 2006, the U.S. Food and Drug Administration granted approval to panitumumab (Vectibix, Amgen, Inc., Thousand Oaks, CA) for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Panitumumab approval is based on the results of a single, open-label, randomized, multinational study that enrolled 463 patients with EGFR-expressing (at least 1+ membrane staining in > or =1% of tumor cells) metastatic colorectal cancer. Patients were randomized to either best supportive care (BSC) alone or BSC plus panitumumab, 6 mg/kg i.v., every other week. The primary study endpoint was progression-free survival (PFS), determined by an independent review committee that was blinded as to treatment assignment. BSC patients who progressed were eligible to receive panitumumab. The study patients' median age was 62 years, with 40% aged > or =65; 63% were male, 99% were white, 86% had a baseline Eastern Cooperative Oncology Group performance status score of 0 or 1, and 67% had colon cancer. The median time from diagnosis of metastases was approximately 19 months and the median number of prior therapies was 2.4. The PFS duration was significantly longer among patients randomized to receive panitumumab in addition to BSC (n = 231) compared with BSC alone (n = 232). The median and mean PFS times were 56 and 96.4 days, respectively, for patients receiving panitumumab and 51 and 59.7 days, respectively, for patients receiving BSC alone. Nineteen partial responses (8%, 95% confidence interval [CI], 5.3%-12.5%) were observed in panitumumab treated patients. The median duration of response was 17 weeks (95% CI, 16-25 weeks). Approximately 75% of patients in the BSC alone arm crossed over to receive panitumumab after disease progression. There was no difference in overall survival between the two study arms. The most common adverse events were skin rash, hypomagnesemia, paronychia, fatigue, abdominal pain, nausea, and diarrhea. The most serious adverse events were pulmonary fibrosis, severe dermatologic toxicity complicated by infectious sequelae and septic death, infusion reactions, abdominal pain, hypomagnesemia, nausea, vomiting, diarrhea, and constipation. JF - The oncologist AU - Giusti, Ruthann M AU - Shastri, Kaushikkumar A AU - Cohen, Martin H AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. ruthann.giusti@fda.hhs.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 577 EP - 583 VL - 12 IS - 5 SN - 1083-7159, 1083-7159 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - panitumumab KW - 6A901E312A KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Analysis of Variance KW - Colorectal Neoplasms -- mortality KW - Disease-Free Survival KW - Infusions, Intravenous KW - Lymphatic Metastasis KW - Colorectal Neoplasms -- metabolism KW - Humans KW - Disease Progression KW - Palliative Care KW - Aged KW - Colorectal Neoplasms -- drug therapy KW - Aged, 80 and over KW - Colorectal Neoplasms -- pathology KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Receptor, Epidermal Growth Factor -- drug effects KW - Receptor, Epidermal Growth Factor -- metabolism KW - Drug Approval KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Receptor, Epidermal Growth Factor -- biosynthesis KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70518862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+panitumumab+%28Vectibix%29.&rft.au=Giusti%2C+Ruthann+M%3BShastri%2C+Kaushikkumar+A%3BCohen%2C+Martin+H%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Giusti&rft.aufirst=Ruthann&rft.date=2007-05-01&rft.volume=12&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Case report: three farmworkers who gave birth to infants with birth defects closely grouped in time and place-Florida and North Carolina, 2004-2005. AN - 70515786; 17520069 AB - There is little evidence linking adverse reproductive effects to exposure to specific pesticides during pregnancy. In February 2005, three infants with congenital anomalies were identified in Collier County, Florida, who were born within 8 weeks of one another and whose mothers worked for the same tomato grower. The mothers worked on the grower's Florida farms in 2004 before transferring to its North Carolina farms. All three worked during the period of organogenesis in fields recently treated with several pesticides. The Florida and North Carolina farms were inspected by regulatory agencies, and in each state a large number of violations were identified and record fines were levied. Despite the suggestive evidence, a causal link could not be established between pesticide exposures and the birth defects in the three infants. Nonetheless, the prenatal pesticide exposures experienced by the mothers of the three infants is cause for concern. Farmworkers need greater protections against pesticides. These include increased efforts to publicize and comply with both the U.S. Environmental Protections Agency's Worker Protection Standard and pesticide label requirements, enhanced procedures to ensure pesticide applicator competency, and recommendations to growers to adopt work practices to reduce pesticide exposures. RELEVANCE TO PROFESSIONAL PRACTICE: The findings from this report reinforce the need to reduce pesticide exposures among farmworkers. In addition, they support the need for epidemiologic studies to examine the role of pesticide exposure in the etiology of congenital anomalies. JF - Environmental health perspectives AU - Calvert, Geoffrey M AU - Alarcon, Walter A AU - Chelminski, Ann AU - Crowley, Mark S AU - Barrett, Rosanna AU - Correa, Adolfo AU - Higgins, Sheila AU - Leon, Hugo L AU - Correia, Jane AU - Becker, Alan AU - Allen, Ruth H AU - Evans, Elizabeth AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. jac6@CDC.GOV Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 787 EP - 791 VL - 115 IS - 5 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Index Medicus KW - Humans KW - North Carolina KW - Infant, Newborn KW - Florida KW - Cluster Analysis KW - Male KW - Female KW - Agriculture -- methods KW - Occupational Exposure -- adverse effects KW - Agriculture -- legislation & jurisprudence KW - Congenital Abnormalities -- etiology KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70515786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Case+report%3A+three+farmworkers+who+gave+birth+to+infants+with+birth+defects+closely+grouped+in+time+and+place-Florida+and+North+Carolina%2C+2004-2005.&rft.au=Calvert%2C+Geoffrey+M%3BAlarcon%2C+Walter+A%3BChelminski%2C+Ann%3BCrowley%2C+Mark+S%3BBarrett%2C+Rosanna%3BCorrea%2C+Adolfo%3BHiggins%2C+Sheila%3BLeon%2C+Hugo+L%3BCorreia%2C+Jane%3BBecker%2C+Alan%3BAllen%2C+Ruth+H%3BEvans%2C+Elizabeth&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2007-05-01&rft.volume=115&rft.issue=5&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-05-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Teratology. 2002;66 Suppl 1:S50-8 [12239745] Occup Med (Lond). 2006 Dec;56(8):532-43 [17151389] Int J Occup Med Environ Health. 2004;17(2):223-43 [15387079] Teratology. 1976 Oct;14(2):171-83 [982313] Toxicol Appl Pharmacol. 1977 Jul;41(1):35-55 [898190] Scand J Work Environ Health. 1990 Jun;16(3):203-7 [2382123] Occup Med. 1997 Apr-Jun;12(2):305-25 [9220488] Reprod Toxicol. 2005 Jul-Aug;20(2):267-70 [15907662] Neurotoxicology. 2005 Aug;26(4):491-510 [16112317] Scand J Work Environ Health. 2005;31 Suppl 1:74-81; discussion 63-5 [16190152] Environ Health Perspect. 2006 Feb;114(2):237-41 [16451860] Pharmacogenet Genomics. 2006 Mar;16(3):183-90 [16495777] MMWR Recomm Rep. 2006 Apr 21;55(RR-6):1-23 [16617292] Environ Health Perspect. 2006 Jul;114(7):985-91 [16835048] Ann Occup Hyg. 2003 Nov;47(8):591-3 [14602666] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. AN - 70470872; 17485608 AB - Current and comprehensive information on the epidemiology of DSM-IV 12-month and lifetime drug use disorders in the United States has not been available. To present detailed information on drug abuse and dependence prevalence, correlates, and comorbidity with other Axis I and II disorders. Face-to-face interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule of the National Institute on Alcohol Abuse and Alcoholism in a large representative sample of US adults (N=43093). Twelve-month and lifetime prevalence of drug abuse and dependence and the associated correlates, treatment rates, disability, and comorbidity with other Axis I and II disorders. Prevalences of 12-month and lifetime drug abuse (1.4% and 7.7%, respectively) exceeded rates of drug dependence (0.6% and 2.6%, respectively). Rates of abuse and dependence were generally greater among men, Native Americans, respondents aged 18 to 44 years, those of lower socioeconomic status, those residing in the West, and those who were never married or widowed, separated, or divorced (all P<.05). Associations of drug use disorders with other substance use disorders and antisocial personality disorder were diminished but remained strong when we controlled for psychiatric disorders. Dependence associations with most mood disorders and generalized anxiety disorder also remained significant. Lifetime treatment- or help-seeking behavior was uncommon (8.1%, abuse; 37.9%, dependence) and was not associated with sociodemographic characteristics but was associated with psychiatric comorbidity. Most individuals with drug use disorders have never been treated, and treatment disparities exist among those at high risk, despite substantial disability and comorbidity. Comorbidity of drug use disorders with other substance use disorders and antisocial personality disorder, as well as dependence with mood disorders and generalized anxiety disorder, appears to be due in part to unique factors underlying each pair of these disorders studied. The persistence of low treatment rates despite the availability of effective treatments indicates the need for vigorous educational efforts for the public and professionals. JF - Archives of general psychiatry AU - Compton, Wilson M AU - Thomas, Yonette F AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 566 EP - 576 VL - 64 IS - 5 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Indians, North American -- statistics & numerical data KW - Comorbidity KW - Antisocial Personality Disorder -- epidemiology KW - Mental Disorders -- diagnosis KW - Adult KW - Health Surveys KW - Disability Evaluation KW - Antisocial Personality Disorder -- diagnosis KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70470872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+disability%2C+and+comorbidity+of+DSM-IV+drug+abuse+and+dependence+in+the+United+States%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Compton%2C+Wilson+M%3BThomas%2C+Yonette+F%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2007-05-01&rft.volume=64&rft.issue=5&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A cross-sectional study of a prototype carcinogenic human papillomavirus E6/E7 messenger RNA assay for detection of cervical precancer and cancer. AN - 70455551; 17473189 AB - To evaluate carcinogenic human papillomavirus (HPV) mRNA for E6 and E7 mRNA detection on clinical specimens to identify women with cervical precancer and cancer. We evaluated a prototype assay that collectively detects oncogenes E6/E7 mRNA for 14 carcinogenic HPV genotypes on a sample of liquid cytology specimens (n=531), masked to clinical data and to the presence of HPV genotypes detected by PGMY09/11 L1 consensus primer PCR assay. We found an increasing likelihood of testing positive for carcinogenic HPV E6/E7 mRNA with increasing severity of cytology (P(Trend) < 0.0001) and histology (P(Trend) < 0.0001), with 94% of cervical intraepithelial neoplasia grade 3 (CIN3) histology cases (46 of 49) and all five cancer cases testing positive for carcinogenic HPV E6/E7 mRNA. Overall, fewer specimens tested positive for carcinogenic HPV E6/E7 mRNA than for carcinogenic HPV DNA (P<0.0001, McNemar's chi(2) test), especially in women with 1 m above exothermic processes. With an accurate solution for the total volumetric flow, ventilation engineers and practicing industrial hygienists are equipped with the necessary information to design and size hoods, as well as place them at an optimal distance from the source to provide adequate control of the rising plume. The equations developed will allow researchers and practitioners to determine the critical control parameters for exothermic processes, such as the exhaust flow necessary to improve efficacy and efficiency, while ensuring adequate worker protection. JF - The Annals of occupational hygiene AU - McKernan, John L AU - Ellenbecker, Michael J AD - National Institute for Occupational Safety and Health, Division of Surveillance Hazard Evaluation and Field Studies, Cincinnati, OH 45226, USA. jmckernan@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 269 EP - 279 VL - 51 IS - 3 SN - 0003-4878, 0003-4878 KW - Index Medicus KW - Physical Phenomena KW - Environment Design KW - Physics KW - Engineering KW - Humans KW - Algorithms KW - Occupational Exposure -- prevention & control KW - Ventilation KW - Hot Temperature -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70493817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Ventilation+equations+for+improved+exothermic+process+control.&rft.au=McKernan%2C+John+L%3BEllenbecker%2C+Michael+J&rft.aulast=McKernan&rft.aufirst=John&rft.date=2007-04-01&rft.volume=51&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The NIDA Methamphetamine Clinical Trials Group: a strategy to increase clinical trials research capacity. AN - 70480549; 17493059 AB - In order to increase the number of investigative teams and sites conducting research on pharmacological treatments for methamphetamine use disorders, the National Institute on Drug Abuse (NIDA) established an infrastructure of clinical sites in areas where methamphetamine addiction is prevalent. This multi-site infrastructure would serve to run multiple Phases II and III protocols effectively and expeditiously. NIDA collaborated with investigators from the University of California at Los Angeles (UCLA) to set up the Methamphetamine Clinical Trials Group (MCTG). This paper describes the development process, as well as data from a test trial to assess the capability of research-naive sites to recruit research participants and conduct study procedures according to research protocol. Subsequent trials are also described. A total of 151 candidates signed consent; 65 individuals were enrolled and 35 (53.8%) completed the 12 weeks' behavioral trial. Self-reported substance use report (SUR) showed comparable use of methamphetamine across sites with the individual site means ranging from 59% (site 5) to 80% (site 3). Drug use as measured by urinalysis was greatly reduced at week 13 compared to the baseline measure; the average rate of methamphetamine-free urine samples across all participants in sites at week 13 was 53%. The highest percentage of methamphetamine-free samples was 85% at site 5; the lowest was at site 1 (40%). Addiction severity index (ASI) composite scores at baseline and protocol completion for all participants demonstrated improvement in all categories over time, except for the medical composite score. The largest composite score reduction in baseline-protocol completion was in the drug domain (0.23 versus 0.15). The changes in the ASI scores from baseline to week 13 were consistent across all five sites. Outcomes of the behavioral trial indicated that the MCTG recruited well; collected study data accurately and reliably; and created a vehicle that can assess promising pharmacotherapies for methamphetamine addiction treatment medications. The MCTG strategy appears to be a feasible approach to increase NIDA's capacity to conduct clinical trials to evaluate potential pharmacotherapies for methamphetamine addiction. JF - Addiction (Abingdon, England) AU - Elkashef, Ahmed AU - Rawson, Richard A AU - Smith, Edwina AU - Pearce, Valerie AU - Flammino, Frank AU - Campbell, Jan AU - Donovick, Roger AU - Gorodetzky, Charles AU - Haning, William AU - Mawhinney, Joseph AU - McCann, Michael AU - Weis, Dennis AU - Williams, Lorie AU - Ling, Walter AU - Vocci, Frank AD - Division of Treatment Research and Development, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 107 EP - 113 VL - 102 Suppl 1 SN - 0965-2140, 0965-2140 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Patient Compliance KW - Humans KW - Adult KW - Treatment Outcome KW - Pilot Projects KW - Substance Abuse Detection -- methods KW - Male KW - Female KW - Amphetamine-Related Disorders -- urine KW - Amphetamine-Related Disorders -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70480549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=The+NIDA+Methamphetamine+Clinical+Trials+Group%3A+a+strategy+to+increase+clinical+trials+research+capacity.&rft.au=Elkashef%2C+Ahmed%3BRawson%2C+Richard+A%3BSmith%2C+Edwina%3BPearce%2C+Valerie%3BFlammino%2C+Frank%3BCampbell%2C+Jan%3BDonovick%2C+Roger%3BGorodetzky%2C+Charles%3BHaning%2C+William%3BMawhinney%2C+Joseph%3BMcCann%2C+Michael%3BWeis%2C+Dennis%3BWilliams%2C+Lorie%3BLing%2C+Walter%3BVocci%2C+Frank&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2007-04-01&rft.volume=102+Suppl+1&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approaches to the development of medications for the treatment of methamphetamine dependence. AN - 70475408; 17493058 AB - Methamphetamine abuse has become an increasing problem in both the United States and globally with concomitant increases in adverse medical, social and environmental sequelae. Behavioral therapies have been used with some success to treat methamphetamine abusers and dependent individuals, but are not universally efficacious. Methamphetamine has a rich pharmacology that theoretically provides many opportunities for potential pharmacotherapeutic intervention. Nevertheless, there are no approved medications with an indication for treating methamphetamine abusers or addicts at this time. To describe briefly how methamphetamine functions and affects function in brain and report how basic researchers and clinicians are attempting to exploit and exploiting this knowledge to discover and develop effective pharmacotherapies. Scientifically based approaches to medications development by evaluating medications that limit brain exposure to methamphetamine; modulate methamphetamine effects at vesicular monoamine transporter-2 (VMAT-2); or affect dopaminergic, serotonergic, GABAergic, and/or glutamatergic brain pathways that participate in methamphetamine's reinforcing effects are presented. The evidence supports the rationale that pharmacotherapies to decrease methamphetamine use, or reduce craving during abstinence may be developed from altering the pharmacokinetics and pharmacodynamics of methamphetamine or its effects on appetitive systems in the brain. JF - Addiction (Abingdon, England) AU - Vocci, Frank J AU - Appel, Nathan M AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 96 EP - 106 VL - 102 Suppl 1 SN - 0965-2140, 0965-2140 KW - Central Nervous System Stimulants KW - 0 KW - GABA Agents KW - Narcotics KW - Serotonin Agents KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Serotonin Agents -- pharmacology KW - Humans KW - Narcotics -- metabolism KW - Dopamine -- metabolism KW - Mice KW - Forecasting KW - Homeostasis KW - GABA Agents -- pharmacology KW - Renin-Angiotensin System -- drug effects KW - Male KW - Female KW - Methamphetamine -- pharmacokinetics KW - Central Nervous System Stimulants -- pharmacology KW - Methamphetamine -- pharmacology KW - Amphetamine-Related Disorders -- drug therapy KW - Immunotherapy -- methods KW - Central Nervous System Stimulants -- pharmacokinetics KW - Amphetamine-Related Disorders -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70475408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Approaches+to+the+development+of+medications+for+the+treatment+of+methamphetamine+dependence.&rft.au=Vocci%2C+Frank+J%3BAppel%2C+Nathan+M&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2007-04-01&rft.volume=102+Suppl+1&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rayon flock: a new cause of respiratory morbidity in a card processing plant. AN - 70459834; 17370318 AB - Following employee respiratory concerns, we investigated the health effects of rayon flock exposure at a card manufacturing plant. We conducted a cross-sectional survey including environmental evaluation, standardized questionnaires, spirometry, carbon monoxide diffusing capacity testing, and methacholine challenge testing. From a total of 239 participants, 146 (61%) reported working at least 1 hr per week in areas where flock-coated cards are processed (flock workers) and 47 (20%) reported cleaning equipment with compressed air. These workers had generally higher prevalences of respiratory symptoms. Flock workers and employees with longer tenure at areas where flock-coated cards are processed were more likely to have restrictive impairment of lung function. Although dust and fiber samples were largely below the detection limits, peak exposures to airborne particulate occurred during cleaning with compressed air. Working with rayon flock and cleaning with compressed air were associated with health effects in workers at this plant. JF - American journal of industrial medicine AU - Antao, Vinicius C S AU - Piacitelli, Chris A AU - Miller, William E AU - Pinheiro, Germania A AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. vinicius.antao@yahoo.com Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 274 EP - 284 VL - 50 IS - 4 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Cellulose KW - 9004-34-6 KW - rayon, purified KW - BX81F82EWG KW - Index Medicus KW - Humans KW - Vital Capacity KW - Forced Expiratory Volume KW - Cross-Sectional Studies KW - Spirometry KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Middle Aged KW - West Virginia -- epidemiology KW - Female KW - Male KW - Prevalence KW - Occupational Diseases -- etiology KW - Cellulose -- toxicity KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Lung Diseases, Interstitial -- etiology KW - Air Pollutants, Occupational -- toxicity KW - Textile Industry KW - Lung Diseases, Interstitial -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70459834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Rayon+flock%3A+a+new+cause+of+respiratory+morbidity+in+a+card+processing+plant.&rft.au=Antao%2C+Vinicius+C+S%3BPiacitelli%2C+Chris+A%3BMiller%2C+William+E%3BPinheiro%2C+Germania+A%3BKreiss%2C+Kathleen&rft.aulast=Antao&rft.aufirst=Vinicius+C&rft.date=2007-04-01&rft.volume=50&rft.issue=4&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential work-related exposures to bloodborne pathogens by industry and occupation in the United States Part II: A telephone interview study. AN - 70442915; 17340611 AB - The companion surveillance portion of this study [Chen and Jenkins, 2007] reported the frequency and rate of potential work-related exposures to bloodborne pathogens (BBP) treated in emergency departments (EDs) by industry and occupation, but it lacks details on the circumstances of the exposure and other relevant issues such as BBP safety training, use of personal protective equipment (PPE) or safety needles, or reasons for seeking treatment in a hospital ED. Telephone interviews were conducted with workers who had been treated in EDs for potential work-related exposures to BBP in 2000-2002. Respondents were drawn from the National Electronic Injury Surveillance System. Of the 593 interviews, 382 were from hospitals, 51 were from emergency medical service/firefighting (EMS/FF), 86 were from non-hospital healthcare settings (e.g., nursing homes, doctors' offices, home healthcare providers, etc.), 22 were from law enforcement (including police and correctional facilities), and 52 were from other non-healthcare settings (i.e., schools, hotels, and restaurants). Needlestick/sharps injuries were the primary source of exposure in hospitals and non-hospital healthcare settings. Skin and mucous membrane was the primary route of exposure in EMS/FF. Human bites accounted for a significant portion of the exposures in law enforcement and other non-healthcare settings. In general, workers from non-hospital settings were less likely to use PPE, to have BBP safety training, to be aware of the BBP standards and exposure treatment procedures, and to report or seek treatment for a work-related exposure compared to hospital workers. This study suggests that each industry group has unique needs that should be addressed. JF - American journal of industrial medicine AU - Chen, Guang X AU - Jenkins, E Lynn AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia, USA. gchen@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 285 EP - 292 VL - 50 IS - 4 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Needlestick Injuries -- complications KW - Telephone KW - Humans KW - Adult KW - Interviews as Topic KW - Middle Aged KW - Needlestick Injuries -- microbiology KW - United States -- epidemiology KW - Population Surveillance KW - Occupational Health KW - Occupational Exposure -- prevention & control KW - Sepsis -- epidemiology KW - Blood-Borne Pathogens KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Emergency Service, Hospital -- utilization KW - Workplace KW - Occupational Diseases -- microbiology KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70442915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Potential+work-related+exposures+to+bloodborne+pathogens+by+industry+and+occupation+in+the+United+States+Part+II%3A+A+telephone+interview+study.&rft.au=Chen%2C+Guang+X%3BJenkins%2C+E+Lynn&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2007-04-01&rft.volume=50&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biocidal activity of three wood essential oils against Ixodes scapularis (Acari: Ixodidae), Xenopsylla cheopis (Siphonaptera: Pulicidae), and Aedes aegypti (Diptera: Culicidae). AN - 70432028; 17461093 AB - The biocidal activity of three steam distilled wood essential oils-incense cedar, Calocedrus decurrens (Torr.) Florin; Port-Orford-cedar, Chamaecyparis lawsoniana (A. Murr.) Parl.; and western juniper, Juniperus occidentalis (Hook)--were evaluated against adult Aedes aegypti (L.) (Diptera: Culicidae) and Xenopsylla cheopis (Rothchild) (Siphonaptera: Pulicidae) and nymphal Ixodes scapularis Say (Acari: Ixodidae). In vitro laboratory bioassays were conducted to establish baseline dose-mortality data through 24 h. Incense cedar heartwood was the most toxic to all three vector species followed in order of activity by western juniper and Port-Orford-cedar based on LC50 and LC90 values. Ae. aegypti were substantially more susceptible to the oils than either I. scapularis or X. cheopis. JF - Journal of economic entomology AU - Dolan, Marc C AU - Dietrich, Gabrielle AU - Panella, Nicholas A AU - Montenieri, John A AU - Karchesy, Joseph J AD - Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA. mcd4@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 622 EP - 625 VL - 100 IS - 2 SN - 0022-0493, 0022-0493 KW - Oils, Volatile KW - 0 KW - Plant Oils KW - cedarwood oil KW - 8023-85-6 KW - Index Medicus KW - Animals KW - Toxicity Tests KW - Cupressaceae -- chemistry KW - Oils, Volatile -- isolation & purification KW - Aedes -- drug effects KW - Plant Oils -- toxicity KW - Wood -- chemistry KW - Siphonaptera -- drug effects KW - Oils, Volatile -- toxicity KW - Ixodes -- drug effects KW - Plant Oils -- isolation & purification KW - Insect Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70432028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+economic+entomology&rft.atitle=Biocidal+activity+of+three+wood+essential+oils+against+Ixodes+scapularis+%28Acari%3A+Ixodidae%29%2C+Xenopsylla+cheopis+%28Siphonaptera%3A+Pulicidae%29%2C+and+Aedes+aegypti+%28Diptera%3A+Culicidae%29.&rft.au=Dolan%2C+Marc+C%3BDietrich%2C+Gabrielle%3BPanella%2C+Nicholas+A%3BMontenieri%2C+John+A%3BKarchesy%2C+Joseph+J&rft.aulast=Dolan&rft.aufirst=Marc&rft.date=2007-04-01&rft.volume=100&rft.issue=2&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Journal+of+economic+entomology&rft.issn=00220493&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-21 N1 - Date created - 2007-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. AN - 70407149; 17450226 AB - Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes. JF - Environmental health perspectives AU - Auman, J Todd AU - Chou, Jeff AU - Gerrish, Kevin AU - Huang, Qihong AU - Jayadev, Supriya AU - Blanchard, Kerry AU - Paules, Richard S AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 572 EP - 578 VL - 115 IS - 4 SN - 0091-6765, 0091-6765 KW - Histamine H1 Antagonists KW - 0 KW - Methapyrilene KW - A01LX40298 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Kidney -- pathology KW - Dose-Response Relationship, Drug KW - Kidney -- drug effects KW - Male KW - Gene Expression Profiling KW - Liver -- pathology KW - Liver -- drug effects KW - Up-Regulation -- drug effects KW - Methapyrilene -- toxicity KW - Histamine H1 Antagonists -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70407149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Identification+of+genes+implicated+in+methapyrilene-induced+hepatotoxicity+by+comparing+differential+gene+expression+in+target+and+nontarget+tissue.&rft.au=Auman%2C+J+Todd%3BChou%2C+Jeff%3BGerrish%2C+Kevin%3BHuang%2C+Qihong%3BJayadev%2C+Supriya%3BBlanchard%2C+Kerry%3BPaules%2C+Richard+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2007-04-01&rft.volume=115&rft.issue=4&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 1999 Jul 30;108(1):37-46 [10472808] Toxicol Sci. 1998 Nov;46(1):185-96 [9928682] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2063-8 [15684063] J Pharmacol Exp Ther. 2005 May;313(2):780-9 [15665138] Nat Methods. 2005 May;2(5):351-6 [15846362] Toxicol Sci. 2005 Jul;86(1):185-93 [15814895] Annu Rev Biochem. 2005;74:739-89 [15952902] Oncogene. 2005 Jul 21;24(31):4921-33 [15897896] Cell Biol Toxicol. 2005 Sep-Nov;21(5-6):215-31 [16323058] Int J Biochem Cell Biol. 2006 Mar;38(3):317-32 [16290097] Environ Health Perspect. 2006 Jan;114(1):92-9 [16393664] Toxicology. 2006 Feb 15;219(1-3):175-86 [16368179] Cell Death Differ. 2006 Mar;13(3):363-73 [16397583] Environ Health Perspect. 2006 Apr;114(4):553-9 [16581545] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E275-81 [16492686] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Chem Biol Interact. 2000 Dec 15;129(3):279-95 [11137066] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Hepatology. 2001 May;33(5):1239-58 [11343254] Curr Opin Cell Biol. 2001 Jun;13(3):349-55 [11343907] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Pharmacogenetics. 2002 Jan;12(1):55-65 [11773865] Pharmacogenomics J. 2002;2(2):117-26 [12049174] Biochem Biophys Res Commun. 2002 Apr 26;293(1):145-9 [12054576] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] J Biol Chem. 2003 Jan 24;278(4):2563-70 [12421815] Biochem Pharmacol. 2003 Mar 1;65(5):857-75 [12628495] Gastroenterology. 2003 May;124(5):1488-99 [12730887] Toxicol Sci. 2003 Jun;73(2):315-28 [12700408] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Environ Health Perspect. 2004 Mar;112(4):439-48 [15033593] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Mutat Res. 2004 May 18;549(1-2):101-13 [15120965] Mutat Res. 2004 May 18;549(1-2):169-83 [15120969] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] Science. 1980 Aug 15;209(4458):817-9 [7403848] Biochem Pharmacol. 1991 Aug 8;42(5):1093-7 [1872894] Toxicology. 1998 Sep 15;130(2-3):79-93 [9865476] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TNF-alpha polymorphisms in chronic beryllium disease and beryllium sensitization. AN - 70375830; 17426528 AB - Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine involved in normal immune functions. The aim of this study was to investigate if there is an association between chronic beryllium disease or beryllium sensitization and two variants of the TNF-alpha gene located at -308 and -238 called TNF-alpha-308*02 and TNF-alpha-238*02. TNF-alpha-308 and TNF-alpha-238 genotyping was conducted in a large, population-based cohort consisting of 886 beryllium workers (92 individuals with chronic beryllium disease, 64 who were beryllium sensitized, and 730 individuals without sensitization or disease). The odds of chronic beryllium disease in the presence of at least one TNF-alpha-308*02 or TNF-alpha-238*02 allele was not significant (OR=1.0; 95% CI=0.7, 1.7 and OR=0.8; 95% CI=0.4, 1.6). This was true regardless of whether a worker was homozygous or heterozygous for TNF-alpha-308*02 or TNF-alpha-238*02. Similarly, neither allele was associated with sensitization (P>0.05). Unlike an earlier report, there was no association between these specific TNF-alpha alleles and either chronic beryllium disease or sensitization to beryllium. JF - Journal of occupational and environmental medicine AU - McCanlies, Erin C AU - Schuler, Christine R AU - Kreiss, Kathleen AU - Frye, Bonnie L AU - Ensey, James S AU - Weston, Ainsley AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. EIM4@CDC/GOV Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 446 EP - 452 VL - 49 IS - 4 SN - 1076-2752, 1076-2752 KW - HLA-DP Antigens KW - 0 KW - HLA-DP beta-Chains KW - HLA-DPB1 antigen KW - Tumor Necrosis Factor-alpha KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - United States KW - Sequence Analysis, Protein KW - Lymphocyte Activation KW - Genotype KW - Alleles KW - Risk Factors KW - Humans KW - HLA-DP Antigens -- genetics KW - Chronic Disease KW - Berylliosis -- immunology KW - Tumor Necrosis Factor-alpha -- chemistry KW - Polymorphism, Genetic KW - Beryllium -- immunology KW - Hypersensitivity -- etiology KW - Occupational Exposure -- adverse effects KW - Hypersensitivity -- genetics KW - Tumor Necrosis Factor-alpha -- genetics KW - Berylliosis -- genetics KW - Beryllium -- blood KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70375830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=TNF-alpha+polymorphisms+in+chronic+beryllium+disease+and+beryllium+sensitization.&rft.au=McCanlies%2C+Erin+C%3BSchuler%2C+Christine+R%3BKreiss%2C+Kathleen%3BFrye%2C+Bonnie+L%3BEnsey%2C+James+S%3BWeston%2C+Ainsley&rft.aulast=McCanlies&rft.aufirst=Erin&rft.date=2007-04-01&rft.volume=49&rft.issue=4&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Perinatal hepatitis B transmission and vaccination timing in a managed care cohort: assessment of the temporary delay in newborn hepatitis B vaccination due to thimerosal content. AN - 70365621; 17414397 AB - From July to September 1999, due to a concern of toxicity from exposure to thimerosal-containing vaccines, the American Academy of Pediatrics and U.S. Public Health Service temporarily recommended delaying the administration of first dose of hepatitis B vaccine until the age of 2-6 months for infants born to hepatitis B surface antigen negative mothers. Our objectives were to determine whether the recommendation affected the rate of perinatal hepatitis B infection in a multistate managed care population; to describe neonatal and early childhood cases of hepatitis B infection and to evaluate a possible role of the recommendation; and to assess the timeliness, with respect to the U.S. childhood immunization schedule, of vaccinations during the first 2 years of life. We identified 3 cohorts of infants born before (July 1998 to June 1999), during (July 1999 to September 1999) and after (October 1999 to September 2000) the recommendation period. We used automated claims data to identify possible neonatal and early childhood hepatitis B cases using specific ICD-9 diagnosis and CPT procedure codes and validated cases through medical record review. Using Health Plan Employer Data and Information Set (HEDIS) data, we calculated vaccination coverage for the first dose of hepatitis B vaccine at 3-month intervals from January 1999 to September 2000. The eligible populations in the "before," "during" and "after" cohorts were 29,347, 7791 and 29,215 infants, respectively. Of 41 possible hepatitis B cases identified in the 3 cohorts, we confirmed 1 case in the after cohort with medical record review. Despite receiving the first dose of hepatitis B vaccine and hepatitis B immunoglobulin within 12-24 hours of birth, the infant was diagnosed with laboratory-confirmed chronic hepatitis B at age of 9 months. An analysis of HEDIS data showed that vaccination coverage for the first dose of hepatitis B vaccine was 98% (January to March 1999) and 96% (April to June 1999) for the "before" cohort and 66% for the "during" cohort. For the "after" cohort the coverage was 72% (October to December 1999), 83% (January to March 2000), 91% (April to June 2000) and 95% (July to September 2000). This study did not identify any perinatal hepatitis B transmission among health plan enrollees associated with the 1999 recommendation. The recommendation did result in a delay of hepatitis B birth dose in the "during" cohort as intended for infants born to hepatitis B surface antigen negative mothers. Six months after the recommendation was rescinded there was still a delay in the timing of first dose of hepatitis B vaccine, but the timing had returned to the prerecommendation level after 9-12 months. JF - The Pediatric infectious disease journal AU - Chang, Soju AU - Begier, Elizabeth M AU - Schech, Stephanie D AU - Venus, Patricia AU - Shatin, Deborah AU - Braun, M Miles AU - Ball, Robert AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 20852, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 329 EP - 333 VL - 26 IS - 4 SN - 0891-3668, 0891-3668 KW - Hepatitis B Vaccines KW - 0 KW - Preservatives, Pharmaceutical KW - Thimerosal KW - 2225PI3MOV KW - Index Medicus KW - United States KW - Infant KW - Humans KW - Immunization Programs -- standards KW - Cohort Studies KW - Infant, Newborn KW - Vaccination KW - Male KW - Female KW - Child, Preschool KW - Thimerosal -- adverse effects KW - Infectious Disease Transmission, Vertical KW - Thimerosal -- administration & dosage KW - Managed Care Programs KW - Hepatitis B -- prevention & control KW - Hepatitis B Vaccines -- adverse effects KW - Hepatitis B Vaccines -- administration & dosage KW - Immunization Schedule KW - Preservatives, Pharmaceutical -- adverse effects KW - Preservatives, Pharmaceutical -- administration & dosage KW - Hepatitis B -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70365621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Perinatal+hepatitis+B+transmission+and+vaccination+timing+in+a+managed+care+cohort%3A+assessment+of+the+temporary+delay+in+newborn+hepatitis+B+vaccination+due+to+thimerosal+content.&rft.au=Chang%2C+Soju%3BBegier%2C+Elizabeth+M%3BSchech%2C+Stephanie+D%3BVenus%2C+Patricia%3BShatin%2C+Deborah%3BBraun%2C+M+Miles%3BBall%2C+Robert&rft.aulast=Chang&rft.aufirst=Soju&rft.date=2007-04-01&rft.volume=26&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=08913668&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding. AN - 70311649; 17141178 AB - The realization that there existed a G-protein coupled signal transduction mechanism developed gradually and was initially the result of an ill fated quest for uncovering the mechanism of action of insulin, followed by a refocused research in many laboratories, including mine, on how GTP acted to increase hormonal stimulation of adenylyl cyclase. Independent research into how light-activated rhodopsin triggers a response in photoreceptor cells of the retina and the attendant biochemical studies joined midway and, without the left hand knowing well what the right hand was doing, preceded classical G protein research in identifying the molecular players responsible for signal transduction by G proteins. JF - Biochimica et biophysica acta AU - Birnbaumer, Lutz AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. birnbau1@niehs.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 756 EP - 771 VL - 1768 IS - 4 SN - 0006-3002, 0006-3002 KW - Guanine Nucleotides KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - GTP-Binding Protein alpha Subunits, Gi-Go KW - EC 3.6.5.1 KW - GTP-Binding Protein alpha Subunits, Gs KW - Heterotrimeric GTP-Binding Proteins KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Animals KW - GTP-Binding Protein alpha Subunits, Gi-Go -- metabolism KW - GTP-Binding Protein alpha Subunits, Gs -- history KW - History, 21st Century KW - History, 20th Century KW - Cholera Toxin -- history KW - Adenylyl Cyclases -- metabolism KW - GTP-Binding Protein alpha Subunits, Gi-Go -- history KW - Pertussis Toxin -- metabolism KW - GTP-Binding Protein alpha Subunits, Gs -- metabolism KW - Binding Sites KW - Pertussis Toxin -- history KW - Adenylyl Cyclases -- drug effects KW - GTP Phosphohydrolases -- metabolism KW - Guanine Nucleotides -- metabolism KW - Guanine Nucleotides -- history KW - Adenylyl Cyclases -- history KW - Cholera Toxin -- metabolism KW - Heterotrimeric GTP-Binding Proteins -- history KW - Heterotrimeric GTP-Binding Proteins -- genetics KW - Heterotrimeric GTP-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70311649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=The+discovery+of+signal+transduction+by+G+proteins%3A+a+personal+account+and+an+overview+of+the+initial+findings+and+contributions+that+led+to+our+present+understanding.&rft.au=Birnbaumer%2C+Lutz&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2007-04-01&rft.volume=1768&rft.issue=4&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1971 Mar 25;246(6):1861-71 [4323237] J Biol Chem. 1971 Mar 25;246(6):1872-6 [4993962] J Biol Chem. 1971 Mar 25;246(6):1877-82 [4926550] Nature. 1971 Jan 22;229(5282):266-9 [4323551] J Clin Endocrinol Metab. 1971 Jun;32(6):860-3 [5577166] Biochem Biophys Res Commun. 1971 Apr 16;43(2):400-8 [5577450] Endocrinology. 1971 Nov;89(5):1186-90 [4328932] Science. 1971 Oct 15;174(4006):295-7 [4330304] J Biol Chem. 1981 Nov 25;256(22):11517-26 [6271754] J Biol Chem. 1984 Feb 25;259(4):2039-42 [6321456] J Biol Chem. 1984 May 10;259(9):5871-86 [6325453] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2424-8 [2833739] Physiol Rev. 2005 Oct;85(4):1159-204 [16183910] J Biol Chem. 1966 Apr 10;241(7):1651-3 [5946622] J Clin Invest. 1967 Jan;46(1):86-94 [6018752] Ann N Y Acad Sci. 1967 Feb 10;139(3):703-23 [5342361] Recent Prog Horm Res. 1968;24:215-54 [4302429] Science. 1969 May 2;164(3879):566-7 [4305077] Proc Natl Acad Sci U S A. 1971 Aug;68(8):1833-7 [4331561] Proc Natl Acad Sci U S A. 1970 Oct;67(2):851-6 [4331724] Science. 1972 Mar 24;175(4028):1363-4 [5059564] J Biol Chem. 1972 Apr 10;247(7):2038-43 [5016642] J Biol Chem. 1972 Apr 10;247(7):2253-4 [4335870] J Biol Chem. 1973 Jul 25;248(14):4901-4 [4352181] J Biol Chem. 1973 Sep 10;248(17):6239-45 [4353635] Biochim Biophys Acta. 1973 Sep 10;300(2):129-58 [4356127] Proc Natl Acad Sci U S A. 1973 Dec;70(12):3820-4 [4359491] Adv Cyclic Nucleotide Res. 1974;4(0):239-81 [4369121] Proc Natl Acad Sci U S A. 1974 Aug;71(8):3087-90 [4607368] Science. 1975 Feb 28;187(4178):750-2 [163487] J Biol Chem. 1975 Mar 25;250(6):2232-7 [163823] J Biol Chem. 1975 Feb 10;250(3):867-76 [1120776] Proc Natl Acad Sci U S A. 1975 Jun;72(6):2064-8 [166378] Biochemistry. 1975 Jun 17;14(12):2760-6 [167806] J Biol Chem. 1975 Aug 25;250(16):6320-7 [169236] FEBS Lett. 1976 Sep 1;67(3):354-8 [964369] Biochim Biophys Acta. 1976 Dec 8;452(2):538-51 [188466] J Biol Chem. 1977 Oct 25;252(20):6966-9 [903346] J Biol Chem. 1977 Oct 25;252(20):7224-34 [903360] Proc Natl Acad Sci U S A. 1977 Aug;74(8):3307-11 [198781] Nature. 1977 Oct 27;269(5631):822-4 [200847] Proc Natl Acad Sci U S A. 1977 Oct;74(10):4238-42 [200909] Proc Natl Acad Sci U S A. 1978 Jun;75(6):2669-73 [208069] Proc Natl Acad Sci U S A. 1978 Jul;75(7):3050-4 [210449] Proc Natl Acad Sci U S A. 1978 Sep;75(9):4155-9 [212737] J Supramol Struct. 1979;10(2):185-90 [222967] J Biol Chem. 1979 Aug 25;254(16):7874-84 [224037] Proc Natl Acad Sci U S A. 1980 Mar;77(3):1408-11 [6103534] J Biol Chem. 1980 Oct 25;255(20):9580-8 [6253447] Proc Natl Acad Sci U S A. 1980 Nov;77(11):6516-20 [6935665] Proc Natl Acad Sci U S A. 1981 Jan;78(1):152-6 [6264430] Biochemistry. 1981 Dec 8;20(25):7068-74 [6119110] J Biol Chem. 1982 Jun 10;257(11):6452-60 [7076677] Proc Natl Acad Sci U S A. 1982 May;79(10):3129-33 [6954463] Biochemistry. 1982 Oct 26;21(22):5516-22 [6293544] J Biol Chem. 1983 Feb 25;258(4):2072-5 [6296122] Nature. 1983 Apr 21;302(5910):706-9 [6300694] Endocrinology. 1983 Aug;113(2):711-9 [6307649] Proc Natl Acad Sci U S A. 1983 Jul;80(14):4276-80 [6308612] J Biol Chem. 1983 Sep 25;258(18):11361-8 [6309843] J Biol Chem. 1983 Sep 25;258(18):11369-76 [6309844] Biochemistry. 1983 Sep 13;22(19):4357-62 [6138091] J Biol Chem. 1981 Aug 25;256(16):8310-7 [7021547] J Biol Chem. 1969 Jul 10;244(13):3468-76 [4307452] J Biol Chem. 1969 Jul 10;244(13):3477-82 [4307453] J Biol Chem. 1970 Feb 25;245(4):718-22 [4313606] Nature. 1970 May 16;226(5246):658-9 [4315553] Proc Natl Acad Sci U S A. 1970 Mar;65(3):745-52 [4315615] Acta Diabetol Lat. 1970 Sep;7 Suppl 1:9-63 [5474742] Endocrinology. 1971 Feb;88(2):332-7 [5540047] Proc Natl Acad Sci U S A. 1971 Mar;68(3):561-2 [4322522] J Biol Chem. 1971 Mar 25;246(6):1849-56 [4993961] J Biol Chem. 1971 Mar 25;246(6):1857-60 [4323236] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC. AN - 70310297; 17358030 AB - Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC can increase the genotoxicity of AZT. Since p53 plays a key role in human and mouse tumorigenesis, p53-haplodeficient mice are currently being evaluated as a model for assessing the carcinogenicity of perinatal exposure to NRTIs. In the present study, male C57BL/6 p53(+/+) and p53(-/-) mice were mated with C3H p53(+/+) females; the pregnant females were treated on gestation day 12 through parturition with 40, 80, and 160 mg/kg of AZT or a combination of 160 mg/kg AZT and 100 mg/kg 3TC (AZT-3TC); the p53(+/+) and p53(+/-) offspring were treated daily after birth through postnatal day (PND) 28. The frequencies of micronucleated reticulocytes (MN-RETs) and micronucleated normochromatic erythrocytes (MN-NCEs) were determined on PND1, PND10, and PND28; the frequency of Hprt mutant lymphocytes was measured on PND28. The frequencies of MN-RETs and MN-NCEs were increased in treated animals at all time points; there were no differences in the responses of p53(+/+) and p53(+/-) animals treated with identical doses of NRTIs. After correction for clonal expansion, both AZT and AZT-3TC treatments induced small but significant increases in the frequency of Hprt mutant lymphocytes in p53(+/-) mice, but not in p53(+/+) mice. The data indicate that p53 haplodeficiency affects the genotoxicity of NRTIs; thus, p53(+/-) mice may be a sensitive model for evaluating the carcinogenicity of perinatal exposure to NRTIs. (c) 2006 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Dobrovolsky, Vasily N AU - Shaddock, Joseph G AU - Mittelstaedt, Roberta A AU - Bishop, Michelle E AU - Lewis, Sherry M AU - Lee, Fei W AU - Aidoo, Anane AU - Leakey, Julian E A AU - Dunnick, June K AU - Heflich, Robert H AD - US Food and Drug Administration, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. PY - 2007 SP - 270 EP - 282 VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Anti-HIV Agents KW - 0 KW - Reverse Transcriptase Inhibitors KW - Tumor Suppressor Protein p53 KW - Lamivudine KW - 2T8Q726O95 KW - Zidovudine KW - 4B9XT59T7S KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Mice KW - Mice, Transgenic KW - Pregnancy KW - Animals, Newborn KW - Maternal-Fetal Exchange KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Tumor Suppressor Protein p53 -- genetics KW - Mutation KW - Lymphocytes -- drug effects KW - Female KW - Male KW - Tumor Suppressor Protein p53 -- deficiency KW - Anti-HIV Agents -- toxicity KW - Lamivudine -- toxicity KW - Zidovudine -- toxicity KW - Reverse Transcriptase Inhibitors -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70310297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Frequency+of+Hprt+mutant+lymphocytes+and+micronucleated+erythrocytes+in+p53-haplodeficient+mice+treated+perinatally+with+AZT+and+AZT+in+combination+with+3TC.&rft.au=Dobrovolsky%2C+Vasily+N%3BShaddock%2C+Joseph+G%3BMittelstaedt%2C+Roberta+A%3BBishop%2C+Michelle+E%3BLewis%2C+Sherry+M%3BLee%2C+Fei+W%3BAidoo%2C+Anane%3BLeakey%2C+Julian+E+A%3BDunnick%2C+June+K%3BHeflich%2C+Robert+H&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2007-04-01&rft.volume=48&rft.issue=3-4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine. AN - 70307741; 16850453 AB - In previous studies, we have shown that zidovudine (3'-azido-3'-deoxythymidine; AZT), but not lamivudine [(-)2',3'-dideoxy-3'-thiacytidine; 3TC], is genotoxic when administered to neonatal mice, and that 3TC when coadministered with AZT does not alter the responses observed with AZT alone (Von Tungeln et al. [2002] Carcinogenesis 23:1427-1432). We now have investigated the transplacental transfer of these drugs and the induction of mutants and micronuclei in the neonatal offspring. From gestational day 12 until parturition, female C57BL/6N and C57BL/6N/Tk(+/-) mice, which had been mated to male C3H/HeNMTV mice, were treated daily by gavage with AZT, 3TC, or a combination of AZT and 3TC. In both dams and fetuses, AZT was found at much higher levels than its metabolites, AZT 5'-glucuronide and 3'-azido-3'-deoxythymidine. In the neonates, AZT and the mixture of AZT and 3TC caused a decrease in the percentage of reticulocytes (RETs) and an increase in the percentage of micronucleated RETs and micronucleated normochromatic erythrocytes. When assessed 3 weeks after birth, AZT and the combination of AZT and 3TC increased the thymidine kinase (Tk) mutant frequency in male mice; at 5 weeks, 3TC increased the Tk mutant frequency in female mice. The increase in Tk mutants in mice treated with AZT and the mixture of AZT and 3TC was associated with loss of the wild-type (Tk(+)) allele (loss of heterozygosity; LOH) and a pattern of discontinuous LOH. These data indicate that AZT, 3TC, and the combination of AZT and 3TC are transplacental mutagens and that the increase in mutants resulting from AZT is due mainly to large-scale genetic alterations. (c) 2006 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Von Tungeln, Linda S AU - Williams, Lee D AU - Doerge, Daniel R AU - Shaddock, Joseph G AU - McGarrity, Lynda J AU - Morris, Suzanne M AU - Mittelstaedt, Roberta A AU - Heflich, Robert H AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. PY - 2007 SP - 258 EP - 269 VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Anti-HIV Agents KW - 0 KW - Mutagens KW - Reverse Transcriptase Inhibitors KW - Lamivudine KW - 2T8Q726O95 KW - Zidovudine KW - 4B9XT59T7S KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Animals KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Polymorphism, Single Nucleotide -- drug effects KW - Mice KW - Pregnancy KW - Animals, Newborn KW - Maternal-Fetal Exchange KW - Mice, Inbred Strains KW - Loss of Heterozygosity -- drug effects KW - Lymphocytes -- drug effects KW - Female KW - Male KW - Thymidine Kinase -- genetics KW - Anti-HIV Agents -- toxicity KW - Lamivudine -- toxicity KW - Zidovudine -- pharmacokinetics KW - Lamivudine -- pharmacokinetics KW - Anti-HIV Agents -- pharmacokinetics KW - Zidovudine -- toxicity KW - Reverse Transcriptase Inhibitors -- pharmacokinetics KW - Mutagens -- toxicity KW - Mutagens -- pharmacokinetics KW - Reverse Transcriptase Inhibitors -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70307741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Transplacental+drug+transfer+and+frequency+of+Tk+and+Hprt+lymphocyte+mutants+and+peripheral+blood+micronuclei+in+mice+treated+transplacentally+with+zidovudine+and+lamivudine.&rft.au=Von+Tungeln%2C+Linda+S%3BWilliams%2C+Lee+D%3BDoerge%2C+Daniel+R%3BShaddock%2C+Joseph+G%3BMcGarrity%2C+Lynda+J%3BMorris%2C+Suzanne+M%3BMittelstaedt%2C+Roberta+A%3BHeflich%2C+Robert+H%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2007-04-01&rft.volume=48&rft.issue=3-4&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells. AN - 70305715; 17358034 AB - 3'-Azido-3'-deoxythymidine (AZT), a nucleoside analogue used for the treatment of acquired immunodeficiency syndrome (AIDS), induced a significant dose-related increase in the thymidine kinase (Tk) mutant frequency (MF) in L5178Y/Tk(+/-) 3.7.2C mouse lymphoma cells. Treatment with 1 mg/ml (3,742 muM) AZT for 24 hr resulted in a MF of 407 x 10(-6) compared to a control MF of 84 x 10(-6). The MFs of the large and small colony mutants resulting from AZT exposure were 142 x 10(-6) and 265 x 10(-6), respectively. One hundred and fifty mutants from the 1 mg/ml (3,742 muM) AZT-treated culture and sixty-nine mutants from independent untreated cultures were isolated and analyzed. LOH analysis using a heteromorphic microsatellite locus located in the Tk gene was performed to determine the presence or absence of the Tk(+) allele. Eight other microsatellite markers spanning the entire mouse chromosome 11 also were examined for heterozygosity to determine the extent of LOH. In addition, Tk gene dosage analysis was conducted using Real-Time PCR in those mutants showing LOH at the Tk locus. The presence of only one Tk allele based on Real-Time PCR indicated that the mutant resulted from deletion while the presence of two alleles was consistent with a recombination event. More mutants from the AZT-treated culture showed Tk LOH than did independent mutants from the untreated cultures (91% vs. 64%) and the induced mutants also showed distinct chromosome 11 LOH patterns. The mutation spectrum of mutants from AZT-treated cells was also significantly different from that of spontaneous mutants. More deletions and fewer intragenic mutations were observed in the mutants from the AZT-treated culture than independent mutants from the untreated control. Our data indicate that AZT primarily induced LOH mutations in L5178Y mouse lymphoma cells and a large number of LOH mutations resulted from deletions. (c) 2006 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Wang, Jianyong AU - Chen, Tao AU - Honma, Masamitsu AU - Chen, Ling AU - Moore, Martha M AD - Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. jianyong.wang@fda.hhs.gov PY - 2007 SP - 248 EP - 257 VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Anti-HIV Agents KW - 0 KW - Reverse Transcriptase Inhibitors KW - Zidovudine KW - 4B9XT59T7S KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Animals KW - Mice KW - Cell Line, Tumor KW - Loss of Heterozygosity -- drug effects KW - Thymidine Kinase -- genetics KW - Anti-HIV Agents -- toxicity KW - Zidovudine -- toxicity KW - Reverse Transcriptase Inhibitors -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70305715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=3%27-azido-3%27-deoxythymidine+induces+deletions+in+L5178Y+mouse+lymphoma+cells.&rft.au=Wang%2C+Jianyong%3BChen%2C+Tao%3BHonma%2C+Masamitsu%3BChen%2C+Ling%3BMoore%2C+Martha+M&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2007-04-01&rft.volume=48&rft.issue=3-4&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complexities of the herbal nomenclature system in traditional Chinese medicine (TCM): lessons learned from the misuse of Aristolochia-related species and the importance of the pharmaceutical name during botanical drug product development. AN - 70279446; 16863692 AB - Herbs used in traditional Chinese medicine (TCM) have diverse cultural/historical backgrounds and are described based on complex nomenclature systems. Using the family Aristolochiaceae as an example, at least three categories of nomenclature could be identified: (1) one-to-one (one plant part from one species): the herb guan mutong refers to the root of Aristolochia manshuriensis; (2) multiple-to-one (multiple plant parts from the same species serve as different herbs): three herbs, madouling, qingmuxiang and tianxianteng, derived respectively from the fruit, root and stem of Aristolochia debilis; and (3) one-to-multiple (one herb refers to multiple species): the herb fangji refers to the root of either Aristolochia fangchi, Stephania tetrandra or Cocculus trilobus; in this case, the first belongs to a different family (Aristolochiaceae) than the latter two (Menispermaceae), and only the first contains aristolochic acid (AA), as demonstrated by independent analytical data provided in this article. Further, mutong (Akebia quinata) is allowed in TCM herbal medicine practice to be substituted with either guan mutong (Aristolochia manshuriensis) or chuan mutong (Clematis armandii); and mu fangji (Cocculus trilobus) by guang fanchi (Aristolochia fangchi) or hanzhong fangji (Aristolochia heterophylla), thereby increasing the risk of exposing renotoxic AA-containing Aristolochia species to patients. To avoid these and other confusions, we wish to emphasize the importance of a pharmaceutical name, which defines the species name, the plant part, and sometimes the special process performed on the herb, including cultivating conditions. The pharmaceutical name as referred to in this article is defined, and is limited to those botanicals that are intended to be used as drug. It is hoped that by following the pharmaceutical name, toxic herbs can be effectively identified and substitution or adulteration avoided. JF - Phytomedicine : international journal of phytotherapy and phytopharmacology AU - Wu, K M AU - Farrelly, J G AU - Upton, R AU - Chen, J AD - Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. kueimeng.wu@fda.hhs.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 273 EP - 279 VL - 14 IS - 4 SN - 0944-7113, 0944-7113 KW - Drugs, Chinese Herbal KW - 0 KW - Index Medicus KW - Humans KW - Medicine, Chinese Traditional KW - Terminology as Topic KW - Drug Labeling KW - Phytotherapy KW - Aristolochia -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70279446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Phytomedicine+%3A+international+journal+of+phytotherapy+and+phytopharmacology&rft.atitle=Complexities+of+the+herbal+nomenclature+system+in+traditional+Chinese+medicine+%28TCM%29%3A+lessons+learned+from+the+misuse+of+Aristolochia-related+species+and+the+importance+of+the+pharmaceutical+name+during+botanical+drug+product+development.&rft.au=Wu%2C+K+M%3BFarrelly%2C+J+G%3BUpton%2C+R%3BChen%2C+J&rft.aulast=Wu&rft.aufirst=K&rft.date=2007-04-01&rft.volume=14&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Phytomedicine+%3A+international+journal+of+phytotherapy+and+phytopharmacology&rft.issn=09447113&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational noise levels during emergency relief operations in the aftermath of Hurricane Katrina. AN - 70272089; 17365492 JF - Journal of occupational and environmental hygiene AU - Achutan, Chandran AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - D33 EP - 5; quiz D36-7 VL - 4 IS - 4 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - Humans KW - Relief Work KW - Occupational Exposure KW - Rescue Work KW - Disasters KW - Noise, Occupational KW - Emergencies -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Occupational+noise+levels+during+emergency+relief+operations+in+the+aftermath+of+Hurricane+Katrina.&rft.au=Achutan%2C+Chandran&rft.aulast=Achutan&rft.aufirst=Chandran&rft.date=2007-04-01&rft.volume=4&rft.issue=4&rft.spage=D33&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A theoretical framework for evaluating analytical digestion methods for poorly soluble particulate beryllium. AN - 70248375; 17124574 AB - Complete digestion of all chemical forms and sizes of particulate analytes in environmental samples is usually necessary to obtain accurate results with atomic spectroscopy. In the current study, we investigate the physicochemical properties of beryllium particles likely to be encountered in samples collected from different occupational environments and present a hypothesis that a dissolution theory can be used as a conceptual framework to guide development of strategies for digestion procedures. For monodisperse single-chemical constituent primary particles, such as those encountered when handling some types of beryllium oxide (BeO) powder, theory predicts that a digestion procedure is sufficient when it completely dissolves all primary particles, independent of cluster size. For polydisperse single-chemical constituent particles, such as those encountered during the handling of some types of beryllium metal powder, theory predicts that a digestion procedure is sufficient only when it completely dissolves the largest particle in the sample. For samples with unknown or multi-chemical constituent particles and with particles having undefined sizes, e.g., fume emissions from a copper-beryllium alloy furnace operation or dust from a beryl ore crushing operation, a surface area-limited and single-constituent-dependent dissolution theory may not predict complete dissolution, thereby requiring non-routine robust treatment procedures with post-digestion filtration, followed by examination of residual particulate material. Additionally, for beryllium, and likely other poorly soluble materials, particulate reference materials of various chemical forms and size distributions are needed to better evaluate and harmonize analytical digestion procedures. Figure Generation of aerosol particles during machining of beryllium oxide. JF - Analytical and bioanalytical chemistry AU - Stefaniak, Aleksandr B AU - Brink, Christopher A AU - Dickerson, Robert M AU - Day, Gregory A AU - Brisson, Michael J AU - Hoover, Mark D AU - Scripsick, Ronald C AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. AStefaniak@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 2411 EP - 2417 VL - 387 IS - 7 SN - 1618-2642, 1618-2642 KW - Aerosols KW - 0 KW - Air Pollutants KW - Dust KW - Powders KW - beryllium oxide KW - 2S8NLR37S3 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Microscopy, Electron, Transmission KW - Solubility KW - Particle Size KW - Models, Statistical KW - Chemistry, Physical -- methods KW - Environmental Monitoring -- methods KW - Chemistry Techniques, Analytical -- methods KW - Beryllium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70248375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=A+theoretical+framework+for+evaluating+analytical+digestion+methods+for+poorly+soluble+particulate+beryllium.&rft.au=Stefaniak%2C+Aleksandr+B%3BBrink%2C+Christopher+A%3BDickerson%2C+Robert+M%3BDay%2C+Gregory+A%3BBrisson%2C+Michael+J%3BHoover%2C+Mark+D%3BScripsick%2C+Ronald+C&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2007-04-01&rft.volume=387&rft.issue=7&rft.spage=2411&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=16182642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Flavoring-related bronchiolitis obliterans. AN - 70246350; 17351470 AB - In 2000, inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Toxicologic and epidemiologic studies in the succeeding 5 years have intervention and research implications. Irreversible obstructive disease exists in workers throughout the microwave popcorn industry, in flavoring manufacture, and in the chemical synthesis of diacetyl, a predominant chemical in butter flavoring. Biologic plausibility of the role of diacetyl and other components of butter flavoring in causing bronchiolitis obliterans exists in rodent experiments which demonstrate respiratory epithelial necrosis. Some risky jobs were associated with short-term peak flavoring exposures, and average 8-h diacetyl exposures as low as 0.02 parts per million were measured in a work area where disease occurred in workers mixing butter flavorings with heated oil. Until safe levels of flavoring chemicals are determined, prevention requires substitution, engineering controls, improved work practices, and personal protective equipment to lower exposure, in conjunction with medical surveillance for accelerated declines in pulmonary function. An epidemiologic approach to longitudinal medical surveillance and flavoring chemical exposures, paired with inhalation toxicology studies of flavoring components, will lay the basis for determining health-protective exposure limits for various flavoring chemicals. JF - Current opinion in allergy and clinical immunology AU - Kreiss, Kathleen AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. kkreiss@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 162 EP - 167 VL - 7 IS - 2 SN - 1528-4050, 1528-4050 KW - Flavoring Agents KW - 0 KW - Butter KW - 8029-34-3 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Humans KW - Bronchiolitis Obliterans -- chemically induced KW - Flavoring Agents -- poisoning KW - Bronchiolitis Obliterans -- epidemiology KW - Occupational Diseases -- epidemiology KW - Diacetyl -- poisoning KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70246350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+allergy+and+clinical+immunology&rft.atitle=Flavoring-related+bronchiolitis+obliterans.&rft.au=Kreiss%2C+Kathleen&rft.aulast=Kreiss&rft.aufirst=Kathleen&rft.date=2007-04-01&rft.volume=7&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+allergy+and+clinical+immunology&rft.issn=15284050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Work-exacerbated asthma. AN - 70243093; 17351467 AB - To summarize recent findings on work-exacerbated asthma, based on medical literature published during 2005 and the first 10 months of 2006. Although prevalence estimates varied considerably among six recent epidemiologic studies, collectively they contribute to the conclusion that work-exacerbated asthma is common. Median work-exacerbated asthma prevalence estimates were 18% of adults with asthma, 25% of working adults with asthma and 45% of all work-related asthma cases. Work-exacerbated asthma can result from a variety of occupational triggers, including physical factors (e.g. extreme temperatures, exercise), behavioral states (e.g. strong emotions, stress), odors (e.g. perfume), general irritants and dust, and second-hand cigarette smoke. Work-exacerbated asthma cases have many of the same demographic and clinical traits as other adults with asthma and occupational asthma cases, although some differences have been reported. Recent review articles have offered some recommendations on the management of work-exacerbated asthma, but more comprehensive advice is anticipated from a professional medical society in the next few years. Epidemiologic studies indicate that work-exacerbated asthma is common. Researchers have started to pay attention to work-exacerbated asthma, but more studies are needed on all aspects of this condition in order to improve diagnosis, management and prevention. JF - Current opinion in allergy and clinical immunology AU - Henneberger, Paul K AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505-2888, USA. pkh0@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 146 EP - 151 VL - 7 IS - 2 SN - 1528-4050, 1528-4050 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Occupational Diseases -- diagnosis KW - Asthma -- epidemiology KW - Occupational Diseases -- immunology KW - Occupational Diseases -- prevention & control KW - Asthma -- prevention & control KW - Occupational Diseases -- epidemiology KW - Asthma -- diagnosis KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70243093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+allergy+and+clinical+immunology&rft.atitle=Work-exacerbated+asthma.&rft.au=Henneberger%2C+Paul+K&rft.aulast=Henneberger&rft.aufirst=Paul&rft.date=2007-04-01&rft.volume=7&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+allergy+and+clinical+immunology&rft.issn=15284050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of dioxins/furans and methyl mercury in fish from the Penobscot river, located near Lincoln, Maine. AN - 70069830; 18220156 AB - The Agency for Toxic Substances and Disease Registry (ATSDR) was requested to review the analytical results of tissue samples from fish caught in the Penobscot river in Maine, calculate fish consumption limits and provide a public health opinion regarding the health implications associated with eating the contaminated fish. Fish consumption limits were calculated to provide guidance on the amount of fish that a person may eat monthly that would probably not pose a public health threat. Earlier, in 1987, the Maine Bureau of Health (BOH) issued a fish consumption advisory for portions of the Penobscot river to protect the public from exposures to dioxins/furans and methyl mercury-contaminated fish. From 1988 to 2003 the state of Maine conducted fish surveys at four locations along the Penobscot river to monitor the levels of dioxins/furans and methyl mercury contamination. In 2005, ATSDR reviewed the sampling results for two fish species (i.e., bottom feeders and predators) collected from the Penobscot river that revealed various levels of dioxins/furans and methyl mercury. The United States Environmental Protection Agency's (US EPA) guidance for evaluating potential health threats associated with contaminated fish recommends that a minimum of two target species be sampled including one predatory and one bottom feeding species. Target species are chosen to meet the following criteria: (1) known to accumulate high concentrations of target contaminants in their tissues; (2) normally populate the freshwater system being studied; (3) are routinely caught and consumed by anglers; (4) nonmigratory; (5) pollutant-tolerant; (6) easily identified; (7) abundant and easy to collect and (8) of sufficient size to provide adequate tissue samples for analyses of contaminants (US EPA, 2000). The analytical results of these fish tissue samples appear to indicate that toxic equivalency quotients concentrations of dioxins/furans have slightly decreased since 1988. In contrast, fish tissue levels of methyl mercury appear to have increased slightly since 1988. Dioxins/furans and methyl mercury levels detected in fish tissue samples caught in the Penobscot river located near Lincoln, Maine, may continue to pose a public health hazard to persons who consume the fish daily, depending on the amount consumed. The ATSDR concurred with Maine BOH's fish advisory for dioxins/furans and methyl mercury, that is, currently in place for portions of the Penobscot river near Lincoln. JF - Toxicology and industrial health AU - Williams, Robert L AU - Cseh, Larry AD - US Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology and Environmental Medicine, 4770 Buford Highway, Mail Stop F-32, Atlanta, GA 30341-3724, USA. RLWilliams@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 147 EP - 153 VL - 23 IS - 3 SN - 0748-2337, 0748-2337 KW - Dioxins KW - 0 KW - Furans KW - Methylmercury Compounds KW - Water Pollutants, Chemical KW - Index Medicus KW - Rivers KW - Animals KW - Environmental Exposure -- analysis KW - Food Contamination KW - Maine KW - Time Factors KW - Dioxins -- analysis KW - Water Pollutants, Chemical -- analysis KW - Fishes KW - Methylmercury Compounds -- analysis KW - Furans -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70069830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=A+review+of+dioxins%2Ffurans+and+methyl+mercury+in+fish+from+the+Penobscot+river%2C+located+near+Lincoln%2C+Maine.&rft.au=Williams%2C+Robert+L%3BCseh%2C+Larry&rft.aulast=Williams&rft.aufirst=Robert&rft.date=2007-04-01&rft.volume=23&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - GEN T1 - Tips for Talking to Children and Youth after Traumatic Events: A Guide for Parents and Educators AN - 62048199; ED499053 AB - Children respond to trauma in many different ways. Some may have reactions very soon after the event; others may do fine for weeks or months, and then begin to show troubling behavior. Knowing the signs that are common at different ages can help parents and teachers recognize problems and respond appropriately. This guide lists common symptoms of emotional stress and trauma at preschool age, in early childhood, and in adolescence. Tips for helping children through a traumatic time are suggested. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 3 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Parents KW - Teachers KW - Symptoms (Individual Disorders) KW - Parent Child Relationship KW - Guidelines KW - Intervention KW - Stress Variables KW - Children KW - Preschool Children KW - Violence KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62048199?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - A Path Toward Interracial Marriage: Women's First Partners and Husbands across Racial Lines AN - 61674653; 200724032 AB - We examine interracial marriage as a culminating event in a sequence of intimate relationships across the life course. Using data from the 1995 National Survey of Family Growth, we analyze the background characteristics associated with selecting a first sex partner and first husband who differ in race/ethnicity from the respondent as well as the continuity across both outcomes. Our results show that respondents' race/ethnicity, parents' education, and region of birth are significant predictors of both choices. Selecting partners across racial lines for first sex is significantly associated with the selection of a first husband across race; the association between both outcomes is particularly strong for non-Hispanic black women, implying that social integration across race may be a life course phenomenon. Adapted from the source document. JF - The Sociological Quarterly AU - King, Rosalind Berkowitz AU - Bratter, Jenifer L AD - Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, 6100 Executive Blvd., Room 8B07, Bethesda, MD 20892-7510 E-mail: rozking@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 343 EP - 369 PB - Blackwell Publishing, Malden MA VL - 48 IS - 2 SN - 0038-0253, 0038-0253 KW - Parental Influence KW - Ethnicity KW - Black White Relations KW - Regional Differences KW - Social Integration KW - Mate Selection KW - Sociodemographic Factors KW - Interpersonal Attraction KW - Intermarriage KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61674653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Sociological+Quarterly&rft.atitle=A+Path+Toward+Interracial+Marriage%3A+Women%27s+First+Partners+and+Husbands+across+Racial+Lines&rft.au=King%2C+Rosalind+Berkowitz%3BBratter%2C+Jenifer+L&rft.aulast=King&rft.aufirst=Rosalind&rft.date=2007-04-01&rft.volume=48&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=The+Sociological+Quarterly&rft.issn=00380253&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-03 N1 - Last updated - 2016-09-28 N1 - CODEN - SOLQAR N1 - SubjectsTermNotLitGenreText - Intermarriage; Mate Selection; Interpersonal Attraction; Sociodemographic Factors; Parental Influence; Social Integration; Black White Relations; Regional Differences; Ethnicity ER - TY - BOOK T1 - Medical Surveillance for Health Care Workers Exposed to Hazardous Drugs AN - 58755696; 2007-23625 AB - Health care workers who handle, prepare, or administer hazardous drugs may face risks to their own health such as skin rashes, cancer, and reproductive disorders. NIOSH recommends that employers establish a medical surveillance program to protect workers who handle hazardous drugs in the workplace. Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Apr 2007, 4 pp. AU - Whalen, John J Y1 - 2007/04// PY - 2007 DA - April 2007 EP - 4p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Radioactive and dangerous substances KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Health conditions and policy - Physicians, nurses, and other health personnel KW - Hazardous materials - Safety measures KW - Medical workers KW - Labor conditions - Medical workers KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Whalen%2C+John+J&rft.aulast=Whalen&rft.aufirst=John&rft.date=2007-04-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Medical+Surveillance+for+Health+Care+Workers+Exposed+to+Hazardous+Drugs&rft.title=Medical+Surveillance+for+Health+Care+Workers+Exposed+to+Hazardous+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/wp-solutions/2007-117/pdfs/2007-117.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - A Technology Review of Smart Sensors with Wireless Networks for Applications in Hazardous Work Environments AN - 58753846; 2007-23626 AB - Workers in hazardous environments such as mining are constantly exposed to the health and safety hazards of dynamic and unpredictable conditions. One approach to enable them to manage these hazards is to provide them with situational awareness: real-time data (environmental, physiological, and physical location data) obtained from wireless, wearable, smart sensor technologies deployed at the work area. Three critical technologies emerge and converge to support this technical approach: smart-wearable sensors, wireless sensor networks, and low-power embedded computing. The major focus of this report is on smart sensors and wireless sensor networks. The "Future Research" section pulls together the three critical technologies by proposing applications that are relevant to mining. Tables. JF - United States National Institute for Occupational Safety and Health (NIOSH), Apr 2007, 59 pp. AU - Fries, Edward F AU - Karra, Vijia K AU - Paddock, Robert AU - Sammarco, John J Y1 - 2007/04// PY - 2007 DA - April 2007 EP - 59p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Science and technology policy - Telecommunications and communication systems KW - Science and technology policy - Technology and technology policy KW - Wireless communication systems KW - Technological innovations - Labor aspects KW - Mining industry - Safety measures KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58753846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fries%2C+Edward+F%3BKarra%2C+Vijia+K%3BPaddock%2C+Robert%3BSammarco%2C+John+J&rft.aulast=Fries&rft.aufirst=Edward&rft.date=2007-04-01&rft.volume=&rft.issue=&rft.spage=59p&rft.isbn=&rft.btitle=A+Technology+Review+of+Smart+Sensors+with+Wireless+Networks+for+Applications+in+Hazardous+Work+Environments&rft.title=A+Technology+Review+of+Smart+Sensors+with+Wireless+Networks+for+Applications+in+Hazardous+Work+Environments&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2007-114.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Progression to Daily Smoking: Is There a Gender Difference among Cessation Treatment Seekers? AN - 57097241; 200801184 AB - The goal of this study was to develop an understanding the developmental trajectory of smoking behaviors in adolescents who seek smoking cessation treatment to inform tailored prevention and treatment efforts; this includes identifying gender differences in smoking behaviors. Smoking trajectory was examined retrospectively in 639 treatment-seeking adolescents (59% female; 44% African American, 50% European American, mean - SD daily cigarettes per day [CPD] 19.16 - 7.2 for both girls and boys). Smoking trajectory variables examined included age at first cigarette, age at daily smoking (a proxy measure for onset of dependence), and age at treatment request. The time interval from first cigarette to daily smoking was shorter for girls than for boys (mean - SD 0.9 - 1.1 years for girls, 1.3 - 1.5 years for boys, p < 0.01). From this clinical sample of adolescent smokers, findings suggest only a brief window of opportunity for secondary preventive interventions before the development of tobacco dependence. Additional research is needed to explore the specific factors that differentially affect smoking trajectory in girls compared to boys. Adapted from the source document. JF - Substance Use & Misuse AU - Thorner, Elissa D AU - Jaszyna-Gasior, Maria AU - Epstein, David H AU - Moolchan, Eric T AD - Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland, USA Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 829 EP - 835 PB - Taylor & Francis, Philadelphia PA VL - 42 IS - 5 SN - 1082-6084, 1082-6084 KW - Smoking KW - Age of onset KW - Gender differences KW - Treatment methods KW - Preventive programmes KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57097241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Progression+to+Daily+Smoking%3A+Is+There+a+Gender+Difference+among+Cessation+Treatment+Seekers%3F&rft.au=Thorner%2C+Elissa+D%3BJaszyna-Gasior%2C+Maria%3BEpstein%2C+David+H%3BMoolchan%2C+Eric+T&rft.aulast=Thorner&rft.aufirst=Elissa&rft.date=2007-04-01&rft.volume=42&rft.issue=5&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080701202486 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-01-04 N1 - Last updated - 2016-09-27 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Adolescents; Smoking; Treatment methods; Age of onset; Gender differences; Preventive programmes DO - http://dx.doi.org/10.1080/10826080701202486 ER - TY - JOUR T1 - On the use of hierarchical probabilistic models for characterizing and managing uncertainty in risk/safety assessment AN - 36808793; 3507782 AB - A general probabilistically-based approach is proposed for both cancer and noncancer risk/safety assessments. The familiar framework of the original ADI/RfD formulation is used, substituting in the numerator a benchmark dose derived from a hierarchical pharmacokinetic/pharmacodynamic model and in the denominator a unitary uncertainty factor derived from a hierarchical animal/average human/sensitive human model. The empirical probability distributions of the numerator and denominator can be combined to produce an empirical human-equivalent distribution for an animal-derived benchmark dose in external-exposure units. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Kodell, Ralph L AU - Chen, James J AD - University of Arkansas ; National Center for Toxicological Research, Jefferson AR Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 433 EP - 438 VL - 27 IS - 2 SN - 0272-4332, 0272-4332 KW - Economics KW - Uncertainty KW - Risk management KW - Probability theory KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36808793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=On+the+use+of+hierarchical+probabilistic+models+for+characterizing+and+managing+uncertainty+in+risk%2Fsafety+assessment&rft.au=Kodell%2C+Ralph+L%3BChen%2C+James+J&rft.aulast=Kodell&rft.aufirst=Ralph&rft.date=2007-04-01&rft.volume=27&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2007.00895.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11038 7625; 13078; 10217 10214 12224 971; 1512 3865 4025 DO - http://dx.doi.org/10.1111/j.1539-6924.2007.00895.x ER - TY - JOUR T1 - Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys AN - 36665514; 3423631 AB - Aim To assess the degree to which methodological differences might influence estimates of prevalence and correlates of substance use and disorders by comparing results from two recent surveys administered to nationally representative US samples. Methods Post-hoc comparison of data from the 2002 National Survey on Drug Use and Health (NSDUH) with data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) administered in 2001-02. Results Prevalence estimates for all substance use outcomes were higher in the NSDUH than in the NESARC: ratios of NSDUH to NESARC prevalences ranged from 2.1 to 5.7 for illegal drug use outcomes. In the NSDUH, past-year substance use disorder (SUD) prevalence estimates were higher for cocaine and heroin, but were similar to NESARC estimates for alcohol, marijuana and hallucinogens. However, prevalence estimates for past-year SUD conditional on past-year use were substantially lower in the NSDUH for marijuana, hallucinogens and cocaine. Associations among drug and SUD outcomes were substantially higher in the NESARC. Total SUD prevalence did not differ between surveys, but estimates for blacks and Hispanics were higher in the NSDUH. Conclusion A number of methodological variables might have contributed to such discrepancies; among plausible candidates are factors related to privacy and anonymity, which may have resulted in higher use estimates in the NSDUH, and differences in SUD diagnostic instrumentation, which may have resulted in higher SUD prevalence among past-year substance users in the NESARC. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Grucza, Richard A AU - Abbacchi, Anna M AU - Przybeck, Thomas R AU - Gfroerer, Joseph C AD - Washington University, St Louis ; Substance Abuse and Mental Health Services Administration, Rockville Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 623 EP - 629 VL - 102 IS - 4 SN - 0965-2140, 0965-2140 KW - Sociology KW - Consumption patterns KW - Survey data KW - Heroin KW - Drug users KW - Social problems KW - Health KW - Addiction KW - Drug abuse KW - Cocaine KW - Substance abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36665514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Discrepancies+in+estimates+of+prevalence+and+correlates+of+substance+use+and+disorders+between+two+national+surveys&rft.au=Grucza%2C+Richard+A%3BAbbacchi%2C+Anna+M%3BPrzybeck%2C+Thomas+R%3BGfroerer%2C+Joseph+C&rft.aulast=Grucza&rft.aufirst=Richard&rft.date=2007-04-01&rft.volume=102&rft.issue=4&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01745.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12356 12357; 561 6220; 5824 3755; 12427 12429; 3754 3755; 2811 2805 3872 554 971; 2435 3755; 3742 1121 11776 3753 3755; 5772; 11893 11979 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01745.x ER - TY - RPRT T1 - Table of contents AN - 236520924 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236520924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-04-01&rft.volume=&rft.issue=537&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236459978 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236459978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-04-01&rft.volume=&rft.issue=537&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIBROMOACETIC ACID (CAS NO. 631-64-1) IN F344/N RATS AND B6C3F^sub 1^ MICE (DRINKING WATER STUDIES) AN - 236441390; 17554398 AB - Dibromoacetic acid occurs as a by-product of chlorination of drinking water. We studied the effects of dibromoacetic acid in drinking water on male and female rats and mice to identify potential toxic or cancer-related hazards. We gave drinking water containing 50, 500 or 1,000 mg of dibromoacetic acid per liter of water to groups of 50 male and female rats and mice for 2 years. Control animals received the same tap water with no chemical added. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival was similar for animals receiving dibromoacetic acid and the controls. Male rats receiving dibromoacetic acid had increased rates of malignant mesotheliomas. The rates of mononuclear cell leukemia increased in exposed female rats and, to a lesser extent, in exposed male rats. Male and female mice exposed to dibromoacetic acid had increased rates of a variety of liver cancer, and lung tumors were increased in male mice and, to a lesser extent, in female mice. We conclude that dibromoacetic acid in the drinking water caused mesothelioma in male rats and mononuclear cell leukemia in female rats, and also possibly in male rats. We conclude that dibromoacetic acid caused liver cancer in male and female mice and lung cancer in male, and possibly also in female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1 EP - 320 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Acetates KW - Carcinogens KW - Environmental Pollutants KW - Mutagens KW - dibromoacetic acid KW - Toxicology KW - Drinking water KW - Acids KW - Lung cancer KW - Liver KW - Animals KW - Drug-Induced Liver Injury -- pathology KW - Water Supply KW - Mesothelioma -- chemically induced KW - Salmonella typhimurium -- drug effects KW - Rats KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Liver -- drug effects KW - CHO Cells KW - Lung Neoplasms -- chemically induced KW - Salmonella typhimurium -- genetics KW - Male KW - Kidney Diseases -- chemically induced KW - Organ Size -- drug effects KW - Administration, Oral KW - Kidney Diseases -- pathology KW - Liver -- pathology KW - Cricetulus KW - Mesothelioma -- secondary KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Testis -- pathology KW - Liver Neoplasms -- chemically induced KW - Mice KW - Mice, Inbred Strains KW - Testis -- drug effects KW - Drug-Induced Liver Injury -- etiology KW - Body Weight -- drug effects KW - Female KW - Cricetinae KW - Lung Neoplasms -- pathology KW - Environmental Pollutants -- toxicity KW - Toxicity Tests KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Acetates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+DIBROMOACETIC+ACID+%28CAS+NO.+631-64-1%29+IN+F344%2FN+RATS+AND+B6C3F%5Esub+1%5E+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-04-01&rft.volume=&rft.issue=537&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2007 N1 - Document feature - Tables; Diagrams; Graphs; Photographs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium AN - 21035296; 8601382 AB - Introduction: - Challenge of guinea-pig tracheal epithelium with hyperosmolar solution alters ion transport and evokes the release of epithelium-derived relaxing factor (EpDRF). Cultured tracheal epithelial cells (CE) offer the potential to examine biochemical pathways related to EpDRF release, but whether the bioelectric properties and responses of fresh, adherent epithelial cells (FE) are modeled by CE has not been established. Methods: Tracheal epithelial cells grown in air-interface culture and fresh tracheal segments were mounted in Ussing chambers to determine short circuit current (I sub(sc)) and transepithelial resistance (R sub(t)) and to compare responses to transport inhibitors, methacholine and hyperosmolarity. Results: Significant differences in basal I sub(sc) and R sub(t) between FE and CE were observed (I sub(sc), 41.3 +/- 3.5 and 8.5 +/- 0.8 mu A/cm super(2), P < 0.05; R sub(t), 106 +/- 7 and 422 +/- 4 [Omega] cm super(2), P < 0.05; respectively); basal spontaneous potential difference values were not different (4.2 +/- 0.3 and 3.4 +/- 0.3 mV, respectively). Amiloride (mucosal, 3 x 10 super(- 5) M), bumetanide (basolateral, 10 super(- 5) M) and ouabain (basolateral, 10 super(- 5) M) reduced I sub(sc) equally in FE and CE. In contrast, NPPB (10 super(- 5) M) in the presence of amiloride had a differential effect, decreasing I sub(sc) by 11% in FE and 71% in CE (P < 0.05). Iberiotoxin (basolateral, 10 super(- 7) M) was without effect in either preparation. In FE, serosal methacholine (3 x 10 super(- 5) M) elicited an NPPB- insensitive monotonic increase in I sub(sc), but in CE caused a large, transient, NPPB-inhibitable increase which was followed by an NPPB-resistant plateau. Addition of apical d-mannitol (0.3-267 mosM) to increase osmolarity decreased I sub(sc) in FE, whereas in CE d-mannitol initially increased (0.3-84.3 mosM) and then decreased (84.3-267 mosM) I sub(sc). Discussion: Cell culture causes substantial changes in the bioelectric and pharmacological properties of respiratory epithelium. Caution should be exercised when using CE as a substitute for FE in studies of ion transport- and cell volume-dependent processes. JF - Journal of Pharmacological and Toxicological Methods AU - Fedan, Jeffrey S AU - Wu, David X-Y AU - Van Scott, Michael R AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, jsf2@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 135 EP - 143 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 55 IS - 2 SN - 1056-8719, 1056-8719 KW - Toxicology Abstracts KW - Airway KW - Bioelectric responses KW - Guinea pig KW - Epithelium KW - Cell culture effects KW - Hyperosmolarity KW - d-Mannitol KW - Methacholine KW - Methods KW - Ussing chamber KW - Epithelial cells KW - Mucosa KW - Amiloride KW - Circuits KW - Cell culture KW - Osmotic pressure KW - bumetanide KW - Mannitol KW - methacholine KW - Ouabain KW - osmolarity KW - Respiratory tract KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacological+and+Toxicological+Methods&rft.atitle=Altered+ion+transport+and+responsiveness+to+methacholine+and+hyperosmolarity+in+air+interface-cultured+guinea-pig+tracheal+epithelium&rft.au=Fedan%2C+Jeffrey+S%3BWu%2C+David+X-Y%3BVan+Scott%2C+Michael+R&rft.aulast=Fedan&rft.aufirst=Jeffrey&rft.date=2007-04-01&rft.volume=55&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacological+and+Toxicological+Methods&rft.issn=10568719&rft_id=info:doi/10.1016%2Fj.vascn.2006.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Mucosa; Amiloride; Cell culture; Circuits; Osmotic pressure; bumetanide; methacholine; Mannitol; Ouabain; Epithelium; osmolarity; Respiratory tract DO - http://dx.doi.org/10.1016/j.vascn.2006.04.005 ER - TY - JOUR T1 - Chromium in Stainless Steel Welding Fume Suppresses Lung Defense Responses Against Bacterial Infection in Rats AN - 20887200; 8403946 AB - Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine which metal component of MMA-SS welding fume alters lung defense responses. At Day 0, rats were intratracheally instilled one time with saline or MMA-SS at a concentration of 2 mg/rat. Additional rats were treated with the metal constituents, Fe2O3, NiO, or Cr2Na2O7 alone or in combination, at concentrations that are present in the dose used for MMA-SS treatment. At Day 3, rats were intratracheally inoculated with 5 t 103 Listeria monocytogenes. At Days 6, 8 and 10, homogenized left lungs were cultured, and colony-forming units were counted after an overnight incubation to assess pulmonary bacterial clearance. At Day 3 (prior to infection) and at Days 6, 8 and 10, right lungs were lavaged to recover cells and fluid from the airspaces to measure lung injury, inflammation, and cytokine secretion. The production of reactive oxygen species by phagocytes recovered from the lungs was measured. Exposure to MMA-SS, soluble Cr, or the mixture of all three metals before infection significantly increased bacterial lung burden and tissue damage when compared to control. Animals treated with NiO or Fe2O3 did not differ from control. Animals pre-treated with soluble Cr had alterations in inflammation and in the production of different cytokines (TNFa, IL-6, IL-2, and IL-12) involved in lung immune responses. This study indicates that soluble Cr present in MMA-SS is likely the primary component responsible for the suppression of lung defense responses associated with stainless steel welding fumes. JF - Journal of Immunotoxicology AU - Antonini, James M AU - Roberts, Jenny R AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 117 EP - 127 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 2 SN - 1547-691X, 1547-691X KW - Toxicology Abstracts; Immunology Abstracts KW - X 24360:Metals KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Chromium+in+Stainless+Steel+Welding+Fume+Suppresses+Lung+Defense+Responses+Against+Bacterial+Infection+in+Rats&rft.au=Antonini%2C+James+M%3BRoberts%2C+Jenny+R&rft.aulast=Antonini&rft.aufirst=James&rft.date=2007-04-01&rft.volume=4&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910701336953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15476910701336953 ER - TY - JOUR T1 - Evaluating Fungal Populations by Genera/Species on Wide Body Commercial Passenger Aircraft and in Airport Terminals AN - 20837693; 7414993 AB - Given the potential health effects of fungi and the amount of time aircrew and passengers spend inside aircraft, it is important to study fungal populations in the aircraft environment. Research objectives included documenting the genera/species of airborne culturable fungal concentrations and total spore concentrations on a twin-aisle wide body commercial passenger aircraft. Twelve flights between 4.5 and 6.5 h in duration on Boeing 767 (B-767) aircraft were evaluated. Two air cooling packs and 50% recirculation rate (i.e. 50:50 mix of outside air and filtered inside air) were utilized during flight operations. Passenger occupancy rates varied from 67 to 100%. N-6 impactors and total spore traps were used to collect sequential, triplicate air samples in the front and rear of coach class during six sampling intervals throughout each flight: boarding, mid-climb, early cruise, mid-cruise, late cruise and deplaning. Comparison air samples were also collected inside and outside the airport terminals at the origin and destination cities resulting in a total of 522 culturable and 517 total spore samples. A total of 45 surface wipe samples were collected using swabs onboard the aircraft and inside the airport terminals. A variety of taxa were observed in the culturable and total spore samples. A frequency analysis of the fungal data indicated that Cladosporium, Aspergillus and Penicillium were predominant genera in the culturable samples whereas Cladosporium, Basidiospores and Penicillium/Aspergillus were predominant in the total spore samples. Fungal populations observed inside the aircraft were comprised of similar genera, detected significantly less frequently and with lower mean concentrations than those observed in typical office buildings. Although sources internal to the aircraft could not be ruled out, our data demonstrate the importance of passenger activity as the source of the fungi observed on aircraft. Isolated fungal peak events occurred occasionally when concentrations of a particular genus or species rose sharply inside the cabin for a limited period. Overall, our research demonstrates that on the sampled flights the B-767 filtration system operated efficiently to remove fungal spores when two air cooling packs and 50% recirculation rate were utilized during flight operations. JF - Annals of Occupational Hygiene AU - Mckernan, Lauralynn Taylor AU - Burge, Harriet AU - Wallingford, Kenneth M AU - Hein, Misty J AU - Herrick, Robert AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations, and Field Studies 4676 Columbia Parkway Cincinnati, OH 45226, USA. Harvard School of Public Health, Department of Environmental Health 401 Park Drive Room 404E Boston, MA 02215, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 281 EP - 291 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 51 IS - 3 SN - 0003-4878, 0003-4878 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Health & Safety Science Abstracts KW - Penicillium KW - Airborne microorganisms KW - Aspergillus KW - taxa KW - Crew safety KW - Public health KW - Flight KW - Aircraft KW - Air sampling KW - Sampling KW - Cladosporium KW - Occupational exposure KW - Urban areas KW - Data processing KW - Fungi KW - Spore traps KW - Population studies KW - Airports KW - Basidiospores KW - Buildings KW - Filtration KW - K 03450:Ecology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20837693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Evaluating+Fungal+Populations+by+Genera%2FSpecies+on+Wide+Body+Commercial+Passenger+Aircraft+and+in+Airport+Terminals&rft.au=Mckernan%2C+Lauralynn+Taylor%3BBurge%2C+Harriet%3BWallingford%2C+Kenneth+M%3BHein%2C+Misty+J%3BHerrick%2C+Robert&rft.aulast=Mckernan&rft.aufirst=Lauralynn&rft.date=2007-04-01&rft.volume=51&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flight; Filtration; Data processing; Aircraft; Spore traps; Fungi; Population studies; Sampling; Airports; Basidiospores; Airborne microorganisms; Air sampling; taxa; Crew safety; Buildings; Occupational exposure; Urban areas; Public health; Penicillium; Aspergillus; Cladosporium ER - TY - JOUR T1 - The fate of metal (Fe) during diesel combustion: Morphology, chemistry, and formation pathways of nanoparticles AN - 20458582; 7639445 AB - This report describes an investigation in which we used iron-doped diesel fuel to generate metal-bearing diesel particles and a subsequent analysis of the particles using transmission electron microscopy (TEM) and energy-dispersive spectroscopy (EDS). For this study, DPM was generated by a 1.5-L diesel engine and the fuel was doped with ferrocene to enhance the level of iron in the system. The exhaust particles were collected on TEM grids and analyzed using the Philips CM12 TEM/EDS instrument. Results show that when the iron-to-carbon (soot) ratio (Fe/C) in the engine is low, the exhaust particles have morphologies similar to those for the undoped case, but at a threshold Fe/C value of 0.013 (for this engine), homogeneously nucleated metallic nanoparticles are formed and begin agglomerating. The number and size of these nanoparticles increase with level of doping. Metal-bearing particles that span a wider size range are also formed. Agglomeration of metallic and carbon particles is observed in two distinct modes: attachment of iron primary particles (5-10 nm in diameter) to carbon agglomerates, and coagulation of iron agglomerates (20-200 nm in diameter) with carbon agglomerates. Results of this work imply that as new engine technologies reduce soot levels in the engine and/or levels of trace metals in the fuel are increased, the generation of metallic nanoparticles may ensue, creating a potential health concern. JF - Combustion and Flame AU - Miller, Art AU - Ahlstrand, Gib AU - Kittelson, David AU - Zachariah, Michael AD - NIOSH/Spokane Research Lab, Spokane, WA 99208, USA, almiller@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 129 EP - 143 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 149 IS - 1-2 SN - 0010-2180, 0010-2180 KW - Pollution Abstracts KW - Nanoparticles KW - Particulate emissions KW - Metallic particles KW - Metal emissions KW - Metals KW - Coagulation KW - Combustion products KW - Fuels KW - Particulates KW - Spectroscopy KW - Soot KW - Microscopy KW - Morphology KW - trace metals KW - Diesel engines KW - Iron KW - Technology KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20458582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combustion+and+Flame&rft.atitle=The+fate+of+metal+%28Fe%29+during+diesel+combustion%3A+Morphology%2C+chemistry%2C+and+formation+pathways+of+nanoparticles&rft.au=Miller%2C+Art%3BAhlstrand%2C+Gib%3BKittelson%2C+David%3BZachariah%2C+Michael&rft.aulast=Miller&rft.aufirst=Art&rft.date=2007-04-01&rft.volume=149&rft.issue=1-2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Combustion+and+Flame&rft.issn=00102180&rft_id=info:doi/10.1016%2Fj.combustflame.2006.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metals; Coagulation; Combustion products; Fuels; Particulates; Spectroscopy; Soot; Morphology; Microscopy; trace metals; Iron; Diesel engines; Technology DO - http://dx.doi.org/10.1016/j.combustflame.2006.12.005 ER - TY - JOUR T1 - Potency assays for therapeutic live whole cell cancer vaccines AN - 20405632; 7428962 AB - Therapeutic cancer vaccines are under development with the goal of enhancing the body's immune response to cancer cells sufficient to arrest cancer cell growth. Among the various approaches being used are those based on whole tumor cells. Developing a suitable measure of the potency of such vaccines presents a significant challenge because neither cellular associated markers nor in vivo biological responses that are correlated with efficacy have been identified; nevertheless, manufacturers and regulatory agencies will need to develop methods to evaluate these products. At this moment, the challenge for manufacturers who are developing whole cell vaccines is to demonstrate batch-to-batch consistency for the vaccine used in clinical studies and to show that comparable vaccine batches have the same capacity to achieve an acceptable level of biological activity that may be related to efficacy. This is particularly challenging in that animal models to test that activity do not exist and direct serological or immunological correlates of clinical protection are not available because protection has not yet been established in clinical trials. In the absence of well-defined biological markers and tests for manufacturing consistency, manufacturers and regulators will need to rely heavily on a highly reproducible manufacturing process-the consistency of the process therefore becomes critical. In developing regulatory approaches to whole cell cancer vaccines, the experience from the field of infectious disease vaccines should be examined for general guidance. A framework that draws heavily on the field of infectious disease vaccines is presented and suggests that at this point in the development of this new class of products, it is reasonable to develop data on quantitative antigen expression as a measure of potency with the expectation that when clinical efficacy has been established it will confirm the appropriateness of this approach. But because this will not be known until the end of a pivotal trial, a bioassay should be considered and run in parallel. Several examples of bioassays are presented along with their advantages and disadvantages. The final selection of a potency assay for use in lot release of a commercializable therapeutic whole cell vaccine ultimately will depend on the totality of the data available at the time of approval by regulatory agencies. Based on information currently available, it is likely that quantitative antigen expression or a bioassay could be used to measure potency. If both are determined to be acceptable, the use of quantitative antigen expression could be considered for routine lot release, while the bioassay could be reserved for use as one of the elements in establishing comparability when manufacturing changes are being considered after approval. JF - Biologicals AU - Petricciani, J AU - Egan, W AU - Vicari, G AU - Furesz, J AU - Schild, G AD - FDA, USA, jpiabs@aol.com Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 107 EP - 113 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 35 IS - 2 SN - 1045-1056, 1045-1056 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cancer vaccines KW - Infectious diseases KW - Animal models KW - Immune response KW - Clinical trials KW - Tumor cells KW - biomarkers KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20405632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Potency+assays+for+therapeutic+live+whole+cell+cancer+vaccines&rft.au=Petricciani%2C+J%3BEgan%2C+W%3BVicari%2C+G%3BFuresz%2C+J%3BSchild%2C+G&rft.aulast=Petricciani&rft.aufirst=J&rft.date=2007-04-01&rft.volume=35&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/10.1016%2Fj.biologicals.2006.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Infectious diseases; Animal models; Immune response; biomarkers; Tumor cells; Clinical trials DO - http://dx.doi.org/10.1016/j.biologicals.2006.05.001 ER - TY - JOUR T1 - Vermiculite, Respiratory Disease, and Asbestos Exposure in Libby, Montana: Update of a Cohort Mortality Study AN - 20388629; 7355663 AB - BACKGROUND: Vermiculite from the mine near Libby, Montana, is contaminated with tremolite asbestos and other amphibole fibers (winchite and richterite). Asbestos-contaminated Libby vermiculite was used in loose-fill attic insulation that remains in millions of homes in the United States, Canada, and other countries. OBJECTIVE: This report describes asbestos-related occupational respiratory disease mortality among workers who mined, milled, and processed the Libby vermiculite. METHODS: This historical cohort mortality study uses life table analysis methods to compare the age-adjusted mortality experience through 2001 of 1,672 Libby workers to that of white men in the U.S. population. RESULTS: Libby workers were significantly more likely to die from asbestosis [standardized mortality ratio (SMR) = 165.8; 95% confidence interval (CI), 103.9-251.1], lung cancer (SMR = 1.7; 95% CI, 1.4-2.1), cancer of the pleura (SMR = 23.3; 95% CI, 6.3-59.5), and mesothelioma. Mortality from asbestosis and lung cancer increased with increasing duration and cumulative exposure to airborne tremolite asbestos and other amphibole fibers. CONCLUSIONS: The observed dose-related increases in asbestosis and lung cancer mortality highlight the need for better understanding and control of exposures that may occur when homeowners or construction workers (including plumbers, cable installers, electricians, telephone repair personnel, and insulators) disturb loose-fill attic insulation made with asbestos-contaminated vermiculite from libby, Montana. JF - Environmental Health Perspectives AU - Sullivan, P A AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Rd., Morgantown, WV 26505 USA, PSullivan@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 579 EP - 585 VL - 115 IS - 4 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Historical account KW - Life tables KW - Environmental health KW - Respiratory diseases KW - Asbestosis KW - Pleura KW - Workers KW - Personnel KW - USA, Montana KW - Construction industry KW - Occupational exposure KW - tremolite KW - Lung cancer KW - Mortality KW - Asbestos KW - Mines KW - Fibers KW - mesothelioma KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20388629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Vermiculite%2C+Respiratory+Disease%2C+and+Asbestos+Exposure+in+Libby%2C+Montana%3A+Update+of+a+Cohort+Mortality+Study&rft.au=Sullivan%2C+P+A&rft.aulast=Sullivan&rft.aufirst=P&rft.date=2007-04-01&rft.volume=115&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Asbestos; Life tables; Mines; Asbestosis; Workers; Fibers; Pleura; Personnel; mesothelioma; tremolite; Occupational exposure; Lung cancer; Historical account; Environmental health; Respiratory diseases; Construction industry; USA, Montana DO - http://dx.doi.org/10.1289/ehp.9481 ER - TY - JOUR T1 - Emergence of community-associated methicillin resistant Staphylococcus aureus in Hawaii, 2001-2003 AN - 20331963; 7585342 AB - Objectives We conducted a retrospective study to determine trends and characteristics of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hawaii. Methods We reviewed medical records of patients with MRSA infections during July 2001-June 2003 in four healthcare facilities. A case was defined as a patient with MRSA infection (colonization excluded), diagnosed in ambulatory settings or <=48h after hospitalization, without previous MRSA or healthcare risk factors. Pulsed-field gel electrophoresis (PFGE) and typing of resistance and toxin genes was performed in 40 MRSA isolates. Results CA-MRSA infections increased from 28 (23% of MRSA infections) to 65 (32%) per quarter over the 2-year period (P<0.05). Pacific islanders accounted for 51% of 389 case-patients, but only 24% of the Hawaii population. In the pediatric hospital, Pacific Islanders represented 76% of 90 case-patients versus 35% of the hospital population. Hospital admission, required for 40% (154/389), was associated with prior antimicrobial treatment (P<0.01). The staphylococcal cassette chromosome mec type IV was detected in 38/40 isolates; 31 isolates carried Panton-Valentine leukocidin genes and 22 belonged to the same staphylococcal lineage. Conclusions In Hawaii, prevention strategies for CA-MRSA infections should focus on Pacific Islanders. CA-MRSA infections in Hawaii appear to be related to strains causing disease throughout the United States. JF - Journal of Infection AU - Estivariz, Concepcion F AU - Park, Sarah Y AU - Hageman, Jeffrey C AU - Dvorin, Jeffrey AU - Melish, Marian M AU - Arpon, Rose AU - Coon, Pat AU - Slavish, Susan AU - Kim, Mary AU - McDougal, Linda K AU - Jensen, Bette AU - McAllister, Sigrid AU - Lonsway, David AU - Killgore, George AU - Effler, Paul E AU - Jernigan, Daniel B AD - Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA, cge3@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 349 EP - 357 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY UK, [URL:http://www.harcourt-international.com] VL - 54 IS - 4 SN - 0163-4453, 0163-4453 KW - Microbiology Abstracts B: Bacteriology KW - Methicillin-resistant Staphylococcus aureus KW - Community-associated KW - Skin infections KW - Pacific Islanders KW - Children KW - Epidemiology KW - leukocidin KW - medical records KW - Pediatrics KW - Drug resistance KW - Infection KW - Toxins KW - Colonization KW - Typing KW - Methicillin KW - Risk factors KW - Pulsed-field gel electrophoresis KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20331963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Emergence+of+community-associated+methicillin+resistant+Staphylococcus+aureus+in+Hawaii%2C+2001-2003&rft.au=Estivariz%2C+Concepcion+F%3BPark%2C+Sarah+Y%3BHageman%2C+Jeffrey+C%3BDvorin%2C+Jeffrey%3BMelish%2C+Marian+M%3BArpon%2C+Rose%3BCoon%2C+Pat%3BSlavish%2C+Susan%3BKim%2C+Mary%3BMcDougal%2C+Linda+K%3BJensen%2C+Bette%3BMcAllister%2C+Sigrid%3BLonsway%2C+David%3BKillgore%2C+George%3BEffler%2C+Paul+E%3BJernigan%2C+Daniel+B&rft.aulast=Estivariz&rft.aufirst=Concepcion&rft.date=2007-04-01&rft.volume=54&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/10.1016%2Fj.jinf.2006.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Colonization; Methicillin; Typing; leukocidin; Pediatrics; medical records; Risk factors; Drug resistance; Pulsed-field gel electrophoresis; Infection; Toxins; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.jinf.2006.08.002 ER - TY - JOUR T1 - DNA adducts in granulocytes of hospital workers exposed to ethylene oxide AN - 20293659; 7512137 AB - Background Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen. Occupational EtO exposure in many countries is regulated at 1 ppm (8-hr TWA), but levels of EtO-DNA adducts in humans with low occupational EtO exposures have not been reported. Methods We examined the formation of N7-(2-hydroxyethyl)guanine (N7-HEG), a major DNA adduct of EtO, in 58 EtO-exposed sterilizer operators and six nonexposed workers from ten hospitals. N7-HEG was quantified in granulocyte DNA (0.1-11.5 µg) by a highly sensitive and specific gas chromatography-electron capture-mass spectrometry method. Cumulative exposure to EtO (ppm-hour) was estimated during the 4-month period before the collection of blood samples. Results There was considerable inter-individual variability in the levels of N7-HEG with a range of 1.6-241.3 adducts/107 nucleotides. The mean levels in the nonexposed, low (32 ppm-hour), and high (>32 ppm-hour) EtO-exposure groups were 3.8, 16.3, and 20.3 adducts/107 nucleotides, respectively, after the adjustment for cigarette smoking and other potential confounders, but the differences were not statistically significant. Conclusions This study has demonstrated for the first time, detectable levels of N7-HEG adducts in granulocytes of hospital workers with EtO exposures at levels less than the current U.S. standard of 1 ppm (8-hr TWA). A nonsignificant increase in adduct levels with increasing EtO exposure indicates that further studies of EtO-exposed workers are needed to clarify the relationship between EtO exposure and N7-HEG adduct formation. Am. J. Ind. Med. 2007. JF - American Journal of Industrial Medicine AU - Yong, Lee C AU - Schulte, Paul A AU - Kao, Chi-Yu AU - Giese, Roger W AU - Boeniger, Mark F AU - Strauss, Gary H S AU - Petersen, Martin R AU - Wiencke, John K AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio, lay7@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 293 EP - 302 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 50 IS - 4 SN - 0271-3586, 0271-3586 KW - ethylene oxide KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Sterilizers KW - DNA adducts KW - Statistical analysis KW - Carcinogens KW - Nucleotides KW - Ethylene oxide KW - Spectrometry KW - Operators KW - Leukocytes (granulocytic) KW - USA KW - Cigarette smoking KW - DNA KW - Occupational exposure KW - Hospitals KW - X 24310:Pharmaceuticals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20293659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=DNA+adducts+in+granulocytes+of+hospital+workers+exposed+to+ethylene+oxide&rft.au=Yong%2C+Lee+C%3BSchulte%2C+Paul+A%3BKao%2C+Chi-Yu%3BGiese%2C+Roger+W%3BBoeniger%2C+Mark+F%3BStrauss%2C+Gary+H+S%3BPetersen%2C+Martin+R%3BWiencke%2C+John+K&rft.aulast=Yong&rft.aufirst=Lee&rft.date=2007-04-01&rft.volume=50&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20443 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sterilizers; Operators; DNA adducts; Leukocytes (granulocytic); Cigarette smoking; Statistical analysis; Carcinogens; Ethylene oxide; Nucleotides; Occupational exposure; Spectrometry; Hospitals; DNA; USA DO - http://dx.doi.org/10.1002/ajim.20443 ER - TY - JOUR T1 - Air Pollution Sources and Childhood Asthma Attacks in Catano, Puerto Rico AN - 20266007; 7403795 AB - Asthma prevalence in the Catano Air Basin of Puerto Rico is 27% for children aged 13-14 years and 45% for children aged 5-6 years. There is concern that these rates are related to air pollution. The authors conducted a nested case-control study to evaluate whether proximity to air pollution point sources was associated with increased risk of asthma attacks. For 1997-2001, 1,382 asthma-related medical visits (International Classification of Diseases, Ninth Revision, codes 493 and 493.9) in children under 17 were identified through health insurance claims. Controls were children with no asthma attacks who were randomly selected from enrollees in two health insurance companies by incidence density sampling (1:5) and matched to cases on gender, age, insurance company, and event date. The distance from a point source to the subject's residence area represented a surrogate exposure measurement. Odds ratios for a 1-km decrease in distance were obtained by conditional logistic regression. Risk of asthma attack was associated with residing near a grain mill (odds ratio (OR) = 1.35), petroleum refinery (OR = 1.44), asphalt plant (OR = 1.23), or power plant (OR = 1.28) (all p's 100 tons/year) increased asthma attack risk by 108% (p < 0.05). These results showed that proximity to some air pollution sources is associated with increased risks of asthma attacks. JF - American Journal of Epidemiology AU - Loyo-Berrios, Nilsa I AU - Irizarry, Rafael AU - Hennessey, Joseph G AU - Tao, Xuguang Grant AU - Matanoski, Genevieve AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, US Department of Health and Human Services, Rockville, MD Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 927 EP - 935 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 8 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts; Risk Abstracts KW - asphalt KW - Basins KW - Pollution effects KW - Asthma KW - Respiratory diseases KW - Refineries KW - Children KW - Insurance KW - Air pollution KW - Classification KW - Asphalt KW - Petroleum KW - Gender KW - Emissions KW - Power plants KW - Grain KW - ASW, Greater Antilles, Puerto Rico KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Air+Pollution+Sources+and+Childhood+Asthma+Attacks+in+Catano%2C+Puerto+Rico&rft.au=Loyo-Berrios%2C+Nilsa+I%3BIrizarry%2C+Rafael%3BHennessey%2C+Joseph+G%3BTao%2C+Xuguang+Grant%3BMatanoski%2C+Genevieve&rft.aulast=Loyo-Berrios&rft.aufirst=Nilsa&rft.date=2007-04-01&rft.volume=165&rft.issue=8&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Air pollution; Classification; Asphalt; Petroleum; Grain; Power plants; Asthma; Children; asphalt; Gender; Emissions; Pollution effects; Basins; Refineries; Respiratory diseases; Insurance; ASW, Greater Antilles, Puerto Rico ER - TY - JOUR T1 - Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells AN - 20223302; 10147257 AB - Honeybee venom hyaluronidase (Api m 2) is a major glycoprotein allergen. Previous studies have indicated that recombinant Api m 2 expressed in insect cells has enzyme activity and IgE binding comparable with that of native Api m 2. In contrast, Api m 2 expressed in Escherichia coli does not. In this study, we characterized the carbohydrate side chains of Api m 2 expressed in insect cells, and compared our data with the established carbohydrate structure of native Api m 2. We assessed both the monosaccharide and the oligosaccharide content of recombinant Api m 2 using fluorophore-assisted carbohydrate electrophoresis and HPLC. To identify the amino acid residues at which glycosylation occurs, we digested recombinant Api m 2 with endoproteinase Glu-C and identified the fragments that contained carbohydrate by specific staining. Recombinant Api m 2 expressed in insect cells contains N-acetylglucosamine, mannose, and fucose, as well as trace amounts of glucose and galactose, and the oligosaccharide analysis is consistent with heterogeneous oligosaccharide chains consisting of two to seven monosaccharides. No sialic acid or N-acetylgalactosamine were detected. These results are similar to published data for native Api m 2, although some monosaccharide components appear to be absent in the recombinant protein. Analysis of proteolytic digests indicates that of the four candidate N-glycosylation sites, carbohydrate chains are attached at asparagines 115 and 263. Recombinant Api m 2 expressed in insect cells has enzymic activity and IgE binding comparable with the native protein, and its carbohydrate composition is very similar. JF - Allergy and Asthma Proceedings AU - Soldatova, Lyudmila N AU - Tsai, Chaoming AU - Dobrovolskaia, Ekaterina AU - Markovic-Housley, Zora AU - Slater, Jay E AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 210 EP - 215 PB - OceanSide Publications, Inc. VL - 28 IS - 2 SN - 1088-5412, 1088-5412 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Immunology Abstracts KW - High-performance liquid chromatography KW - Galactose KW - Proteolysis KW - N-Acetylgalactosamine KW - Glucose KW - Apis mellifera KW - Glycosylation KW - monosaccharides KW - N-Acetylglucosamine KW - Asparagine KW - N-glycans KW - Insect cells KW - Allergens KW - Escherichia coli KW - Carbohydrates KW - Glycoproteins KW - Hyaluronoglucuronidase KW - oligosaccharides KW - Data processing KW - Electrophoresis KW - Amino acids KW - Mannose KW - Enzymes KW - fucose KW - Carbohydrate composition KW - Immunoglobulin E KW - Venom KW - Sialic acids KW - J 02410:Animal Diseases KW - Z 05300:General KW - F 06925:Hypersensitivity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20223302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Allergy+and+Asthma+Proceedings&rft.atitle=Characterization+of+the+N-glycans+of+recombinant+bee+venom+hyaluronidase+%28Api+m+2%29+expressed+in+insect+cells&rft.au=Soldatova%2C+Lyudmila+N%3BTsai%2C+Chaoming%3BDobrovolskaia%2C+Ekaterina%3BMarkovic-Housley%2C+Zora%3BSlater%2C+Jay+E&rft.aulast=Soldatova&rft.aufirst=Lyudmila&rft.date=2007-04-01&rft.volume=28&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Allergy+and+Asthma+Proceedings&rft.issn=10885412&rft_id=info:doi/10.2500%2Faap.2007.28.2947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Proteolysis; Galactose; High-performance liquid chromatography; N-Acetylgalactosamine; Glucose; N-Acetylglucosamine; monosaccharides; Glycosylation; Asparagine; Allergens; Insect cells; N-glycans; Glycoproteins; Carbohydrates; Hyaluronoglucuronidase; Amino acids; Electrophoresis; Data processing; oligosaccharides; Mannose; Enzymes; fucose; Carbohydrate composition; Immunoglobulin E; Venom; Sialic acids; Escherichia coli; Apis mellifera DO - http://dx.doi.org/10.2500/aap.2007.28.2947 ER - TY - JOUR T1 - A detailed mutagenesis study of flavivirus cross-reactive epitopes using West Nile virus-like particles AN - 19668595; 7432249 AB - Human flavivirus infections elicit virus species-specific and cross-reactive immune responses. The flavivirus envelope (E) glycoprotein is the primary antigen inducing protective immunity; however, the presence of cross-reactive antibodies in human sera creates problems for serodiagnosis. Using a West Nile virus-like particle system, we performed mutagenesis across all three E protein functional domains to identify epitope determinants for a panel of monoclonal antibodies (mAbs) raised against different flaviviruses and exhibiting diverse patterns of cross-reactivity. Residues within the highly conserved fusion peptide were the only epitope determinants identified and were important not only for broadly cross-reactive mAbs recognizing all of the medically important flavivirus serocomplexes, but also for less-broad, complex-reactive mAbs. Moreover, different substitutions at specific fusion peptide residues produced highly variable effects on antibody reactivity and virus-like particle secretion. These results support and extend the conclusion that the fusion peptide region constitutes an immunodominant epitope stimulating antibodies with diverse patterns of cross-reactivity. Primer sequences are available in Supplementary Table S1 in JGV Online. JF - Journal of General Virology AU - Crill, Wayne D AU - Trainor, Nicole B AU - Chang, Gwong-Jen J AD - Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Service, PO Box 2087, Fort Collins, CO 80522, USA, wcrill@cdc.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 1169 EP - 1174 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK VL - 88 IS - 4 SN - 0022-1317, 0022-1317 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts; Virology & AIDS Abstracts KW - Virus-like particles KW - Cross-reactivity KW - Monoclonal antibodies KW - Nucleotide sequence KW - Immunity KW - Infection KW - Flavivirus KW - Mutagenesis KW - Public health KW - Envelopes KW - Antigens KW - Viral diseases KW - Envelope protein KW - Primers KW - Glycoproteins KW - Epitopes KW - Phylogenetics KW - Q1 08205:Genetics and evolution KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Virology&rft.atitle=A+detailed+mutagenesis+study+of+flavivirus+cross-reactive+epitopes+using+West+Nile+virus-like+particles&rft.au=Crill%2C+Wayne+D%3BTrainor%2C+Nicole+B%3BChang%2C+Gwong-Jen+J&rft.aulast=Crill&rft.aufirst=Wayne&rft.date=2007-04-01&rft.volume=88&rft.issue=4&rft.spage=1169&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Virology&rft.issn=00221317&rft_id=info:doi/10.1099%2Fvir.0.82640-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Antigens; Viral diseases; Monoclonal antibodies; Nucleotide sequence; Glycoproteins; Phylogenetics; Public health; Mutagenesis; Envelopes; Cross-reactivity; Virus-like particles; Envelope protein; Primers; Immunity; Infection; Epitopes; Flavivirus DO - http://dx.doi.org/10.1099/vir.0.82640-0 ER - TY - JOUR T1 - Analysis of Multiple Differing Copies of the 16S rRNA Gene in Five Clinical Isolates and Three Type Strains of Nocardia Species and Implications for Species Assignment AN - 19655659; 7407424 AB - Five clinical isolates of Nocardia that showed ambiguous bases within the variable region of the 16S rRNA gene sequence were evaluated for the presence of multiple copies of this gene. The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which also showed ambiguous bases in the variable region, were also examined. Cloning experiments using an amplified region of the 16S rRNA that contains the variable region showed that each isolate possessed 16S rRNA genes with at least two different sequences. In addition, hybridization studies using a 16S rRNA gene-specific probe and extracted genomic DNA of the patient isolates and of the type strain of N. ignorata showed that each isolate possessed at least three copies of the gene. These multiple differing copies of the 16S rRNA gene and the results of DNA-DNA hybridization studies indicate problems of species definition and identification for such isolates. A broader species concept than that currently in vogue may be required to accommodate such organisms. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20882-1508 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1146 EP - 1151 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 4 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - DNA probes KW - genomics KW - Nocardia KW - rRNA 16S KW - Variable region KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19655659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Analysis+of+Multiple+Differing+Copies+of+the+16S+rRNA+Gene+in+Five+Clinical+Isolates+and+Three+Type+Strains+of+Nocardia+Species+and+Implications+for+Species+Assignment&rft.au=Conville%2C+Patricia+S%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2007-04-01&rft.volume=45&rft.issue=4&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; DNA probes; genomics; rRNA 16S; Variable region; Nocardia ER - TY - JOUR T1 - Simulated Workplace Protection Factors for Half-Facepiece Respiratory Protective Devices AN - 19579503; 8501956 AB - This study investigates two different methods (random effects model and 5th percentile) for determining the performance of three types of respiratory protective devices (elastomeric N95 respirators, N95 filtering-facepiece respirators, and surgical masks) during a simulated workplace test. This study recalculated the protection level of three types of respiratory protective devices using the random effects model, compared the two methods with each other and the APF of 10 for half-facepiece respirators, and determined the value of each of the fit test protocols in attaining the desired level of simulated workplace protection factor (SWPF). Twenty-five test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020 and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. Each of the six tests produced an SWPF. To determine the level of protection provided by the respiratory protective devices, a 90% lower confidence limit for the simulated workplace protection factor (SWPFLCL90%) and the 5th percentile of simulated workplace protection factor were computed. The 5th percentile method values could be up to seven times higher than the SWPFLCL90% values. Without fit testing, all half-facepiece N95 respirators had a 5th percentile of 4.6 and an SWPFLCL90% value of 2.7. N95 filtering-facepiece respirators as a class had values of 3.3 and 2.0, respectively, whereas N95 elastomeric respirators had values of 7.3 and 4.6, respectively. Surgical masks did not provide any protection, with values of 1.2 and 1.4, respectively. Passing either the Bitrex, saccharin, or Companion fit test resulted in the respirators providing the expected level of protection with 5th percentiles greater than or equal to 10 except when passing the Bitrex test with N95 filtering-facepiece respirators, which resulted in a 5th percentile of only 7.9. No substantial difference was seen between the three fit tests. All of the SWPFLCL90% values after passing a fit test were less than 10. The random model method provides a more conservative estimate of the protection provided by a respirator because it takes into account both between- and within-wearer variability. JF - Journal of Occupational and Environmental Hygiene AU - Duling, Matthew G AU - Lawrence, Robert B AU - Slaven, James E AU - Coffey, Christopher C AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 420 EP - 431 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 6 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Hazardous materials KW - Occupational safety KW - Respirators KW - Protective equipment KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19579503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Simulated+Workplace+Protection+Factors+for+Half-Facepiece+Respiratory+Protective+Devices&rft.au=Duling%2C+Matthew+G%3BLawrence%2C+Robert+B%3BSlaven%2C+James+E%3BCoffey%2C+Christopher+C&rft.aulast=Duling&rft.aufirst=Matthew&rft.date=2007-04-01&rft.volume=4&rft.issue=6&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701346925 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hazardous materials; Occupational safety; Respirators; Protective equipment DO - http://dx.doi.org/10.1080/15459620701346925 ER - TY - JOUR T1 - Trends in workplace homicides in the U.S., 1993-2002: A decade of decline AN - 19454360; 7512139 AB - Background Trends in workplace homicide rates are compared to the trends in U.S. homicides from 1993 to 2002, inclusively. The homogeneity of workplace homicide rates by victim demographics, circumstances, and types of events are also addressed. Methods Using publicly available data from several sources, Poisson models are used to statistically compare the trends of workplace homicide rates versus U.S. homicide rates and to compare trends within categories of workplace homicides. Results Overall, there was a significant decline in the rates of occupational homicide of approximately 6% per year during the study time period; this decline was found to be statistically greater than the decline of all U.S. homicides (5% per year). Taxi cab drivers and chauffeurs demonstrated the greatest decline of all occupational subgroups. When looking at the circumstances of workplace homicides, only the rate of homicides committed during a robbery or other crime demonstrated a significant decline. Conclusions While workplace homicides have declined in the U.S., the declines have not occurred uniformly across demographic and occupational categories. Am. J. Ind. Med. 2007. JF - American Journal of Industrial Medicine AU - Hendricks, Scott A AU - Jenkins, E Lynn AU - Anderson, Kristi R AD - National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, West Virginia, sah5@cdc.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 316 EP - 325 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 50 IS - 4 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - USA KW - homicide KW - Occupational safety KW - Violence KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+in+workplace+homicides+in+the+U.S.%2C+1993-2002%3A+A+decade+of+decline&rft.au=Hendricks%2C+Scott+A%3BJenkins%2C+E+Lynn%3BAnderson%2C+Kristi+R&rft.aulast=Hendricks&rft.aufirst=Scott&rft.date=2007-04-01&rft.volume=50&rft.issue=4&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - homicide; Occupational safety; Violence; USA DO - http://dx.doi.org/10.1002/ajim.20442 ER - TY - JOUR T1 - Impact of a targeted hepatitis B vaccination program in Amsterdam, The Netherlands. AN - 70297086; 16919856 AB - To evaluate hepatitis B virus (HBV) risk group vaccination in Amsterdam, which started in 1998, we examined 342 reported acute HBV-cases and sequenced 85 DNA isolates. The reported number of cases declined from 214 in 1992-1997 to 128 in 1998-2003, due to a decline in injecting drug users (IDU) and their heterosexual partners. Phylogenetic analyses showed that after 1998, the IDU cluster nearly disappeared, probably due to a decline in injecting. Acute HBV remained stable among men having sex with men; given their increased sexual risk behavior, vaccination has probably prevented an increase in their acute infections. Currently, 48-72% of the people who should be included in the program are still susceptible to HBV. JF - Vaccine AU - van Houdt, Robin AU - Sonder, Gerard J B AU - Dukers, Nicole H T M AU - Bovee, Lian P M J AU - van den Hoek, Anneke AU - Coutinho, Roel A AU - Bruisten, Sylvia M AD - GGD, Public Health Service, Department of Infectious Diseases, Amsterdam, The Netherlands. rvhoudt@ggd.amsterdam.nl Y1 - 2007/03/30/ PY - 2007 DA - 2007 Mar 30 SP - 2698 EP - 2705 VL - 25 IS - 14 SN - 0264-410X, 0264-410X KW - Hepatitis B Vaccines KW - 0 KW - Index Medicus KW - Homosexuality, Male KW - Netherlands -- epidemiology KW - Phylogeny KW - Hepatitis B virus -- classification KW - Humans KW - Retrospective Studies KW - Hepatitis B virus -- genetics KW - Hepatitis B -- etiology KW - Genotype KW - Substance Abuse, Intravenous -- complications KW - Female KW - Male KW - Hepatitis B -- epidemiology KW - Hepatitis B Vaccines -- immunology KW - Vaccination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70297086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Impact+of+a+targeted+hepatitis+B+vaccination+program+in+Amsterdam%2C+The+Netherlands.&rft.au=van+Houdt%2C+Robin%3BSonder%2C+Gerard+J+B%3BDukers%2C+Nicole+H+T+M%3BBovee%2C+Lian+P+M+J%3Bvan+den+Hoek%2C+Anneke%3BCoutinho%2C+Roel+A%3BBruisten%2C+Sylvia+M&rft.aulast=van+Houdt&rft.aufirst=Robin&rft.date=2007-03-30&rft.volume=25&rft.issue=14&rft.spage=2698&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2007-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Drive to Produce Evenly-Distributed Coatings of Reagents in the Equatorial Plane of 37-mm Glass Fiber Membrane Filters T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40579180; 4540320 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Tucker, Samuel P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Filters KW - Glass KW - Coating materials KW - Membranes KW - Fibers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40579180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Drive+to+Produce+Evenly-Distributed+Coatings+of+Reagents+in+the+Equatorial+Plane+of+37-mm+Glass+Fiber+Membrane+Filters&rft.au=Tucker%2C+Samuel+P&rft.aulast=Tucker&rft.aufirst=Samuel&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Pathway-Focused PCR Array for Expression Profiling of Drug Metabolizing Genes T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40575749; 4535124 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Guo, L AU - Dial, S AU - Shi, L AU - Ning, B AU - Sun, Y AU - Wang, J AU - Yang, J AU - Dragan, Y P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Drugs KW - Polymerase chain reaction KW - Profiling KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40575749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Evaluation+of+Pathway-Focused+PCR+Array+for+Expression+Profiling+of+Drug+Metabolizing+Genes&rft.au=Guo%2C+L%3BDial%2C+S%3BShi%2C+L%3BNing%2C+B%3BSun%2C+Y%3BWang%2C+J%3BYang%2C+J%3BDragan%2C+Y+P&rft.aulast=Guo&rft.aufirst=L&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Urinary 2-Butoxyacetic Acid: Development of an Effective Gas Chromatographic Test Method for Quantification T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40575619; 4535102 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - B'Hymer, C AU - Cheever, K L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Urine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40575619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Urinary+2-Butoxyacetic+Acid%3A+Development+of+an+Effective+Gas+Chromatographic+Test+Method+for+Quantification&rft.au=B%27Hymer%2C+C%3BCheever%2C+K+L&rft.aulast=B%27Hymer&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Pulmonary Responses to Single-Walled vs. Multi-Walled Carbon Nanotubes T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40574208; 4535066 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Castranova, V Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Carbon KW - Lung KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40574208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Comparison+of+Pulmonary+Responses+to+Single-Walled+vs.+Multi-Walled+Carbon+Nanotubes&rft.au=Castranova%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro 2-Methoxyacetaldehyde Adduct Formation Used for Proteomic-Based Glycol Ether Biomarker Development with Surface Enhanced Laser Desorption Ionization (SELDI) Analysis T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40573193; 4535100 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Cheever, K L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Bioindicators KW - Ethers KW - Lasers KW - Desorption KW - Adducts KW - Ionization KW - Biomarkers KW - Glycol ethers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=In+Vitro+2-Methoxyacetaldehyde+Adduct+Formation+Used+for+Proteomic-Based+Glycol+Ether+Biomarker+Development+with+Surface+Enhanced+Laser+Desorption+Ionization+%28SELDI%29+Analysis&rft.au=Cheever%2C+K+L&rft.aulast=Cheever&rft.aufirst=K&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - (2-Methoxyethoxy)Acetic Acid: A Urinary Biomarker of Exposure to JP-8 Jet Fuel T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40571356; 4535101 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Butler, M A AU - B'Hymer, C B AU - Cheever, K L AU - Krieg, E AU - Toennis, C A AU - Clark, J C AU - Gibson, R L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Bioindicators KW - Fuels KW - Urine KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40571356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=%282-Methoxyethoxy%29Acetic+Acid%3A+A+Urinary+Biomarker+of+Exposure+to+JP-8+Jet+Fuel&rft.au=Butler%2C+M+A%3BB%27Hymer%2C+C+B%3BCheever%2C+K+L%3BKrieg%2C+E%3BToennis%2C+C+A%3BClark%2C+J+C%3BGibson%2C+R+L&rft.aulast=Butler&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ab Initio Study of the Interaction of the Phospholipid Head-Group with Representative Quartz and Aluminosilicate Structures T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40570138; 4540138 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Snyder, James Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Phospholipids KW - Quartz KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Ab+Initio+Study+of+the+Interaction+of+the+Phospholipid+Head-Group+with+Representative+Quartz+and+Aluminosilicate+Structures&rft.au=Snyder%2C+James&rft.aulast=Snyder&rft.aufirst=James&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prenatal and Neonatal Mice are More Sensitive to Mutagenicity of Carcinogens than Adults T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40570076; 4536628 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Chen, T AU - Mei, N AU - Moore, M M AU - Heflich, R H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Carcinogens KW - Mutagenicity KW - Mice KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Prenatal+and+Neonatal+Mice+are+More+Sensitive+to+Mutagenicity+of+Carcinogens+than+Adults&rft.au=Chen%2C+T%3BMei%2C+N%3BMoore%2C+M+M%3BHeflich%2C+R+H&rft.aulast=Chen&rft.aufirst=T&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Process Map for Qualification of Genomic Biomarkers of Drug Safety T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40564545; 4536866 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Goodsaid, F M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Bioindicators KW - Drugs KW - Genomics KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40564545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Process+Map+for+Qualification+of+Genomic+Biomarkers+of+Drug+Safety&rft.au=Goodsaid%2C+F+M&rft.aulast=Goodsaid&rft.aufirst=F&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insidious Vascular Inflammatory Response and Identification of Early Predictive Biomarkers in Rat Following Oral Administration of the PDE IV Inhibitor Sch 351591. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40563932; 4536834 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Zhang, J AU - Snyder, R AU - Knapton, A AU - Miller, T J AU - Espandiari, P AU - Herman, E H AU - Honchel, R AU - Hanig, J AU - Weaver, J L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Bioindicators KW - Vascular system KW - Phosphodiesterase IV KW - Oral administration KW - Inflammation KW - Biomarkers KW - Prediction KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40563932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Insidious+Vascular+Inflammatory+Response+and+Identification+of+Early+Predictive+Biomarkers+in+Rat+Following+Oral+Administration+of+the+PDE+IV+Inhibitor+Sch+351591.&rft.au=Zhang%2C+J%3BSnyder%2C+R%3BKnapton%2C+A%3BMiller%2C+T+J%3BEspandiari%2C+P%3BHerman%2C+E+H%3BHonchel%2C+R%3BHanig%2C+J%3BWeaver%2C+J+L&rft.aulast=Zhang&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Eukaryotic Translation Elongation Factor 1d Overexpressing Cells are Resistant to Cadmium-Induced Toxicity and Apoptosis T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40562756; 4536604 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Othumpangat, S AU - Umbright, C AU - Joseph, P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Toxicity KW - Apoptosis KW - Translation elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Eukaryotic+Translation+Elongation+Factor+1d+Overexpressing+Cells+are+Resistant+to+Cadmium-Induced+Toxicity+and+Apoptosis&rft.au=Othumpangat%2C+S%3BUmbright%2C+C%3BJoseph%2C+P&rft.aulast=Othumpangat&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Gene Polymorphisms and Susceptibility to Chronic Inflammatory Diseases in Occupational Settings T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40562722; 4536863 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Yucesoy, B AU - Luster, M I Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Cytokines KW - Gene polymorphism KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Cytokine+Gene+Polymorphisms+and+Susceptibility+to+Chronic+Inflammatory+Diseases+in+Occupational+Settings&rft.au=Yucesoy%2C+B%3BLuster%2C+M+I&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and in Vitro Dibutyl Phthalate Skin Absorption in Hairless Guinea Pig Skin T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40562212; 4536823 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Yourick, J J AU - Doan, K AU - Bronaugh, R L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Skin KW - Phthalates KW - Absorption KW - Hairless KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=In+Vivo+and+in+Vitro+Dibutyl+Phthalate+Skin+Absorption+in+Hairless+Guinea+Pig+Skin&rft.au=Yourick%2C+J+J%3BDoan%2C+K%3BBronaugh%2C+R+L&rft.aulast=Yourick&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Nanotube Respiratory Exposure and Risk from Systemic Effects T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40561112; 4535699 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Simeonova, P P AU - Li, Z. AU - Erdely, A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Carbon KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40561112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Carbon+Nanotube+Respiratory+Exposure+and+Risk+from+Systemic+Effects&rft.au=Simeonova%2C+P+P%3BLi%2C+Z.%3BErdely%2C+A&rft.aulast=Simeonova&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ketamine-Induced Oxidative Stress and DNA Repair in Monkey Frontal Cortical Culture during Development T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560992; 4536433 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Wang, C AU - Sadovova, N AU - Zou, X AU - Scallet, A C AU - Charlotte, H E AU - Patterson, T A AU - Hanig, J P AU - Paule, M G AU - Slikker, W Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Stress KW - Oxidative stress KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Ketamine-Induced+Oxidative+Stress+and+DNA+Repair+in+Monkey+Frontal+Cortical+Culture+during+Development&rft.au=Wang%2C+C%3BSadovova%2C+N%3BZou%2C+X%3BScallet%2C+A+C%3BCharlotte%2C+H+E%3BPatterson%2C+T+A%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W&rft.aulast=Wang&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Glutaraldehyde Risk Assessment using Benchmark Doses: Decisions, Decisions, Decisions! T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560464; 4536492 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Dankovic, D A AU - Bailer, A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Risk assessment KW - Benchmarks KW - Glutaraldehyde KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=A+Glutaraldehyde+Risk+Assessment+using+Benchmark+Doses%3A+Decisions%2C+Decisions%2C+Decisions%21&rft.au=Dankovic%2C+D+A%3BBailer%2C+A&rft.aulast=Dankovic&rft.aufirst=D&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Buprenorphine Potentiates Methamphetamine-Induced Extracellular Dopamine Release in Rat Caudate-Putamen T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560299; 4536176 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Gough, B AU - Ali, S F AU - Binienda, Z K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Buprenorphine KW - Caudate-putamen KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Buprenorphine+Potentiates+Methamphetamine-Induced+Extracellular+Dopamine+Release+in+Rat+Caudate-Putamen&rft.au=Gough%2C+B%3BAli%2C+S+F%3BBinienda%2C+Z+K&rft.aulast=Gough&rft.aufirst=B&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accumulation of Nanoscale Quantum Dots in Multiple Organs In Vivo, Following Dermal Exposure to Dermabraded, but not Tape Stripped or Intact SKH-1 Mouse Skin T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560018; 4536151 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Gopee, N V AU - Roberts, D W AU - Cozart, C AU - Siitonen, P H AU - Walker, N J AU - Yu, W W AU - Colvin, V L AU - Howard, P C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Organs KW - Skin KW - Quantum dots KW - Bioaccumulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Accumulation+of+Nanoscale+Quantum+Dots+in+Multiple+Organs+In+Vivo%2C+Following+Dermal+Exposure+to+Dermabraded%2C+but+not+Tape+Stripped+or+Intact+SKH-1+Mouse+Skin&rft.au=Gopee%2C+N+V%3BRoberts%2C+D+W%3BCozart%2C+C%3BSiitonen%2C+P+H%3BWalker%2C+N+J%3BYu%2C+W+W%3BColvin%2C+V+L%3BHoward%2C+P+C&rft.aulast=Gopee&rft.aufirst=N&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Murine Model of Occupational Rhinitis Following Inhalation of Toluene Diisocyanate. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559618; 4536050 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Johnson, V J AU - Yucesoy, B AU - Luster, M I Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Inhalation KW - Toluene KW - Rhinitis KW - Animal models KW - Toluene diisocyanate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=A+Novel+Murine+Model+of+Occupational+Rhinitis+Following+Inhalation+of+Toluene+Diisocyanate.&rft.au=Johnson%2C+V+J%3BYucesoy%2C+B%3BLuster%2C+M+I&rft.aulast=Johnson&rft.aufirst=V&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Synephrine and Bitter Orange on Cardiovascular and Physiological Variables in Female Rats. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559573; 4536109 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Duffy, P AU - White, G AU - Appana, S AU - Pellicore, L AU - Frankos, V AU - Hansen, D K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Rats KW - Physiology KW - Citrus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Effects+of+Synephrine+and+Bitter+Orange+on+Cardiovascular+and+Physiological+Variables+in+Female+Rats.&rft.au=Duffy%2C+P%3BWhite%2C+G%3BAppana%2C+S%3BPellicore%2C+L%3BFrankos%2C+V%3BHansen%2C+D+K&rft.aulast=Duffy&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship between Low Dose Peanut Exposures and the Percent of Peanut-Sensitized and Peanut-Allergic Individuals that React T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559395; 4536264 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Assimon, S AU - Bolger, P M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nuts KW - Arachis hypogaea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Relationship+between+Low+Dose+Peanut+Exposures+and+the+Percent+of+Peanut-Sensitized+and+Peanut-Allergic+Individuals+that+React&rft.au=Assimon%2C+S%3BBolger%2C+P+M&rft.aulast=Assimon&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Genetic Variation in Acrylamide Metabolism on Hemoglobin Adduct Levels T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559166; 4536126 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Reutman, S AU - Butler, M AU - Vesper, H AU - Moorman, W AU - Toennis, C AU - Clark, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolism KW - Genetic diversity KW - Adducts KW - Acrylamide KW - Hemoglobin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Impact+of+Genetic+Variation+in+Acrylamide+Metabolism+on+Hemoglobin+Adduct+Levels&rft.au=Reutman%2C+S%3BButler%2C+M%3BVesper%2C+H%3BMoorman%2C+W%3BToennis%2C+C%3BClark%2C+J&rft.aulast=Reutman&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabonomics Evaluation of Urine from Rats Dosed with Acetaminophen using NMR and UPLC/MS T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559032; 4534860 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Beger, R D AU - Schnackenberg, L K AU - Sun, J AU - Holland, R D AU - Reily, M D AU - Robertson, D G AU - Cantor, G H AU - Dragan, Y P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - N.M.R. KW - Urine KW - Rats KW - Acetaminophen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Metabonomics+Evaluation+of+Urine+from+Rats+Dosed+with+Acetaminophen+using+NMR+and+UPLC%2FMS&rft.au=Beger%2C+R+D%3BSchnackenberg%2C+L+K%3BSun%2C+J%3BHolland%2C+R+D%3BReily%2C+M+D%3BRobertson%2C+D+G%3BCantor%2C+G+H%3BDragan%2C+Y+P&rft.aulast=Beger&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glutathione-Mediated Protection Against Chromium-Induced Dermal Toxicity T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558939; 4536815 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Joseph, P AU - Noore, J AU - Umbright, C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Toxicity KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Glutathione-Mediated+Protection+Against+Chromium-Induced+Dermal+Toxicity&rft.au=Joseph%2C+P%3BNoore%2C+J%3BUmbright%2C+C&rft.aulast=Joseph&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dispersion Significantly Enhances the Pulmonary Toxicity of Single Walled Carbon Nanotubes. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558553; 4535907 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Mercer, R R AU - Scabilloni, J F AU - Wang, L AU - Schwegler-Berry, D AU - Shvedova, A A AU - Castranova, V Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Toxicity KW - Carbon KW - Lung KW - Nanotubes KW - Dispersion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Dispersion+Significantly+Enhances+the+Pulmonary+Toxicity+of+Single+Walled+Carbon+Nanotubes.&rft.au=Mercer%2C+R+R%3BScabilloni%2C+J+F%3BWang%2C+L%3BSchwegler-Berry%2C+D%3BShvedova%2C+A+A%3BCastranova%2C+V&rft.aulast=Mercer&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk-Risk Assessment of Methylmercury (MeHg)Exposure and Fish Consumption T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558446; 4536504 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Carrington, C D AU - Murray, C W AU - Bolger, P M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Pisces KW - Methyl mercury KW - Dimethylmercury KW - Fish consumption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Risk-Risk+Assessment+of+Methylmercury+%28MeHg%29Exposure+and+Fish+Consumption&rft.au=Carrington%2C+C+D%3BMurray%2C+C+W%3BBolger%2C+P+M&rft.aulast=Carrington&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Urinary Proteomic-based Biomarker Development for Evaluation of Occupational Exposure using SELDI-TOF Mass Spectrometry T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558064; 4534852 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Mathias, P I AU - Cheever, K L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mass spectroscopy KW - Bioindicators KW - Occupational exposure KW - Urine KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Urinary+Proteomic-based+Biomarker+Development+for+Evaluation+of+Occupational+Exposure+using+SELDI-TOF+Mass+Spectrometry&rft.au=Mathias%2C+P+I%3BCheever%2C+K+L&rft.aulast=Mathias&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety Assessment of Dietary Supplements Marketed for Weight Loss: FDA Perspectives T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557887; 4536882 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Frankos, V H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - FDA KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Safety+Assessment+of+Dietary+Supplements+Marketed+for+Weight+Loss%3A+FDA+Perspectives&rft.au=Frankos%2C+V+H&rft.aulast=Frankos&rft.aufirst=V&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Therapeutic and Toxic Doses of Acetaminophen in Rat Livers T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557828; 4535416 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Orr, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Liver KW - Acetaminophen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Microarray+Analysis+of+Therapeutic+and+Toxic+Doses+of+Acetaminophen+in+Rat+Livers&rft.au=Orr%2C+M&rft.aulast=Orr&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of ALOE Vera Whole Leaf Extract on the Growth and Short Chain Fatty Acid Production by Bacteroides Fragilis, Bifidobacterium Infantis, and Eubacterium Limosum. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557751; 4536405 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Pogribna, M AU - Freeman, J P AU - Paine, D AU - Beland, F A AU - Boudreau, M D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Fatty acids KW - Leaves KW - Growth KW - Eubacterium limosum KW - Bacteroides fragilis KW - Aloe vera KW - Bifidobacterium infantis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Effects+of+ALOE+Vera+Whole+Leaf+Extract+on+the+Growth+and+Short+Chain+Fatty+Acid+Production+by+Bacteroides+Fragilis%2C+Bifidobacterium+Infantis%2C+and+Eubacterium+Limosum.&rft.au=Pogribna%2C+M%3BFreeman%2C+J+P%3BPaine%2C+D%3BBeland%2C+F+A%3BBoudreau%2C+M+D&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroinflammatory Responses Following Exposure to Engineered Nanomaterials T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557582; 4536143 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Sriram, K AU - Porter, D W AU - Tsuruoka, S AU - Endo, M AU - Jefferson, A M AU - Wolfarth, M G AU - Rogers, G M AU - Castranova, V AU - Luster, M I Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Neuroinflammatory+Responses+Following+Exposure+to+Engineered+Nanomaterials&rft.au=Sriram%2C+K%3BPorter%2C+D+W%3BTsuruoka%2C+S%3BEndo%2C+M%3BJefferson%2C+A+M%3BWolfarth%2C+M+G%3BRogers%2C+G+M%3BCastranova%2C+V%3BLuster%2C+M+I&rft.aulast=Sriram&rft.aufirst=K&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacological Differentiation of Early and Late Phase Asthma-Like Response in Trimellitic Anhydride (TMA) Sensitized and Challenged Brown Norway Rats. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557199; 4536056 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Zhang, X D AU - Siegel, P D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Norway KW - Rats KW - Differentiation KW - Trimellitic anhydride KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Pharmacological+Differentiation+of+Early+and+Late+Phase+Asthma-Like+Response+in+Trimellitic+Anhydride+%28TMA%29+Sensitized+and+Challenged+Brown+Norway+Rats.&rft.au=Zhang%2C+X+D%3BSiegel%2C+P+D&rft.aulast=Zhang&rft.aufirst=X&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin E Deficiency Enhances Pulmonary Inflammatory Response and Oxidative Stress Induced by Single Walled Carbon Nanotubes in C57BL/6 Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556910; 4534969 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Shvedova, A A AU - Kisin, E R AU - Murray, A R AU - Gorelik, O AU - Arepalli, S AU - Castranova, V AU - Young, S H AU - Gao, F AU - Tyurina, Y Y AU - Oury, T AU - Kagan, V E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Stress KW - Mice KW - Oxidative stress KW - Carbon KW - Lung KW - Nutrient deficiency KW - Vitamin E KW - Inflammation KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Vitamin+E+Deficiency+Enhances+Pulmonary+Inflammatory+Response+and+Oxidative+Stress+Induced+by+Single+Walled+Carbon+Nanotubes+in+C57BL%2F6+Mice&rft.au=Shvedova%2C+A+A%3BKisin%2C+E+R%3BMurray%2C+A+R%3BGorelik%2C+O%3BArepalli%2C+S%3BCastranova%2C+V%3BYoung%2C+S+H%3BGao%2C+F%3BTyurina%2C+Y+Y%3BOury%2C+T%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Metrics for Assessment of Microarray Assay Performance using a Mixed Tissue RNA Reference Sample T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556667; 4535784 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Pine, P S AU - Boedigheimer, M AU - Rosenzweig, B A AU - Turpaz, Y AU - He, Y. AU - Delenstarr, G AU - Shippy, R AU - Ganter, B AU - Jarnagin, K AU - Jones, W AU - Reid, L AU - Thompson, K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Evaluation+of+Metrics+for+Assessment+of+Microarray+Assay+Performance+using+a+Mixed+Tissue+RNA+Reference+Sample&rft.au=Pine%2C+P+S%3BBoedigheimer%2C+M%3BRosenzweig%2C+B+A%3BTurpaz%2C+Y%3BHe%2C+Y.%3BDelenstarr%2C+G%3BShippy%2C+R%3BGanter%2C+B%3BJarnagin%2C+K%3BJones%2C+W%3BReid%2C+L%3BThompson%2C+K&rft.aulast=Pine&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: II. Prediction of Human Liver and Kidney Effects using an Adverse Effects Database, MC4PC, and Bioepisteme T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556587; 4535776 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Matthews, E J AU - Ursem, C J AU - Kruhlak, N L AU - Benz, R AU - Prous, J AU - Aragones, D AU - Ivanov, J AU - Klopman, G AU - Contrera, J F Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Side effects KW - Kidneys KW - Liver KW - Databases KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+II.+Prediction+of+Human+Liver+and+Kidney+Effects+using+an+Adverse+Effects+Database%2C+MC4PC%2C+and+Bioepisteme&rft.au=Matthews%2C+E+J%3BUrsem%2C+C+J%3BKruhlak%2C+N+L%3BBenz%2C+R%3BProus%2C+J%3BAragones%2C+D%3BIvanov%2C+J%3BKlopman%2C+G%3BContrera%2C+J+F&rft.aulast=Matthews&rft.aufirst=E&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repeated Exposure to 1->3-ss-Glucan Suppresses Lung Defense Responses and Slows the Pulmonary Clearance of Listeria monocytogenes in Rats T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556459; 4535320 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Young, S AU - Roberts, J R AU - Antonini, J M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lung KW - Rats KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Repeated+Exposure+to+1-%26gt%3B3-ss-Glucan+Suppresses+Lung+Defense+Responses+and+Slows+the+Pulmonary+Clearance+of+Listeria+monocytogenes+in+Rats&rft.au=Young%2C+S%3BRoberts%2C+J+R%3BAntonini%2C+J+M&rft.aulast=Young&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The use of a Flow Cytometry-Based Cytokine Analysis for Bronchoalveolar Lavage with Confirmation by Real-Time RT-PCR in a Mouse Model of Pulmonary Inflammation T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556425; 4535317 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Zeidler-Erdely, P C AU - Erdely, A D AU - Young, S AU - Antonini, J M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Bronchus KW - Cytokines KW - Lung KW - Polymerase chain reaction KW - Alveoli KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+use+of+a+Flow+Cytometry-Based+Cytokine+Analysis+for+Bronchoalveolar+Lavage+with+Confirmation+by+Real-Time+RT-PCR+in+a+Mouse+Model+of+Pulmonary+Inflammation&rft.au=Zeidler-Erdely%2C+P+C%3BErdely%2C+A+D%3BYoung%2C+S%3BAntonini%2C+J+M&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lung Inflammation and Cardiovascular Outcomes - Whole Blood Gene Expression Studies in a Lipopolysaccharide (LPS) Pharyngeal Aspiration Mouse Model T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556250; 4535244 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Erdely, A AU - Salmen, R AU - Chapman, R AU - Hulderman, T AU - Simeonova, P P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lung KW - Lipopolysaccharides KW - Gene expression KW - Pharynx KW - Blood KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Lung+Inflammation+and+Cardiovascular+Outcomes+-+Whole+Blood+Gene+Expression+Studies+in+a+Lipopolysaccharide+%28LPS%29+Pharyngeal+Aspiration+Mouse+Model&rft.au=Erdely%2C+A%3BSalmen%2C+R%3BChapman%2C+R%3BHulderman%2C+T%3BSimeonova%2C+P+P&rft.aulast=Erdely&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of Brain Cell Replication and Neurotransmitter Systems during Development Leading to Cognitive Dysfunction: Developmental Neurotoxicity of Nicotine T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556187; 4535382 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Slikker, W AU - Xu , Z. AU - Levin, E D AU - Slotkin, T A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nicotine KW - Neurotoxicity KW - Brain KW - Neurotransmitters KW - Replication KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Disruption+of+Brain+Cell+Replication+and+Neurotransmitter+Systems+during+Development+Leading+to+Cognitive+Dysfunction%3A+Developmental+Neurotoxicity+of+Nicotine&rft.au=Slikker%2C+W%3BXu+%2C+Z.%3BLevin%2C+E+D%3BSlotkin%2C+T+A&rft.aulast=Slikker&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Gene-Expression Profiling of Tamoxifen-Induced Rat Hepatocarcinogenesis T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556155; 4535460 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Bagnyukova, T V AU - Pogribny, I AU - Han, T AU - Moland, C AU - Beland, F A AU - Fuscoe, J C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Gene expression KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Global+Gene-Expression+Profiling+of+Tamoxifen-Induced+Rat+Hepatocarcinogenesis&rft.au=Bagnyukova%2C+T+V%3BPogribny%2C+I%3BHan%2C+T%3BMoland%2C+C%3BBeland%2C+F+A%3BFuscoe%2C+J+C&rft.aulast=Bagnyukova&rft.aufirst=T&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exercise Provides Neuroprotection Against Kainic Acid Toxicity through Induction of the Chemokine MCP-1 in the Hippocampus of C57BL/6J Mice. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555989; 4536172 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Benkovic, S A AU - Sriram, K AU - O'Callaghan, J P AU - Miller, D B Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mice KW - Toxicity KW - Monocyte chemoattractant protein 1 KW - Kainic acid KW - Neuroprotection KW - Chemokines KW - Hippocampus KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Exercise+Provides+Neuroprotection+Against+Kainic+Acid+Toxicity+through+Induction+of+the+Chemokine+MCP-1+in+the+Hippocampus+of+C57BL%2F6J+Mice.&rft.au=Benkovic%2C+S+A%3BSriram%2C+K%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MPP+-Induced Alterations in Selective Gene Expression Correlate with Dopaminergic Depletion in MN9D Cells T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555950; 4535928 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Wang, J AU - Duhart, H M AU - Xu, Z. AU - Patterson, T A AU - Newport, G D AU - Ali, S F Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Gene expression KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=MPP%2B-Induced+Alterations+in+Selective+Gene+Expression+Correlate+with+Dopaminergic+Depletion+in+MN9D+Cells&rft.au=Wang%2C+J%3BDuhart%2C+H+M%3BXu%2C+Z.%3BPatterson%2C+T+A%3BNewport%2C+G+D%3BAli%2C+S+F&rft.aulast=Wang&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicology of Titanium Dioxide (TiO2) Nanoparticles: 1. Characterization and Tissue Distribution in Subcutaneously and Intravenously Injected Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555927; 4536139 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Umbreit, T AU - Weaver, J L AU - Miller, T J AU - Zhang, J AU - Shah, R AU - Khan, M A AU - Stratmeyer, M E AU - Tomazic-Jezic, V Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Titanium dioxide KW - Mice KW - Nanoparticles KW - Toxicology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Toxicology+of+Titanium+Dioxide+%28TiO2%29+Nanoparticles%3A+1.+Characterization+and+Tissue+Distribution+in+Subcutaneously+and+Intravenously+Injected+Mice&rft.au=Umbreit%2C+T%3BWeaver%2C+J+L%3BMiller%2C+T+J%3BZhang%2C+J%3BShah%2C+R%3BKhan%2C+M+A%3BStratmeyer%2C+M+E%3BTomazic-Jezic%2C+V&rft.aulast=Umbreit&rft.aufirst=T&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sources of Variability in Baseline Gene Expression in Rat Liver and Kidney T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555680; 4535785 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Thompson, K AU - Bass, M AU - Boedigheimer, M AU - Bushel, P AU - Chou, J AU - Corton, J C AU - Fostel, J AU - Liu, F AU - Wolfinger, R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Kidneys KW - Liver KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Sources+of+Variability+in+Baseline+Gene+Expression+in+Rat+Liver+and+Kidney&rft.au=Thompson%2C+K%3BBass%2C+M%3BBoedigheimer%2C+M%3BBushel%2C+P%3BChou%2C+J%3BCorton%2C+J+C%3BFostel%2C+J%3BLiu%2C+F%3BWolfinger%2C+R&rft.aulast=Thompson&rft.aufirst=K&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: I. Construction of a Relational Database of Adverse Human Effects using Fda Archives, Pharmapendium, and Public Sources T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555638; 4535775 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Ursem, C J AU - Matthews, E J AU - Kruhlak, N L AU - Benz, R AU - MacLaughlin, P AU - Contrera, J F Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Side effects KW - FDA KW - Databases KW - Pharmaceuticals KW - Archives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+I.+Construction+of+a+Relational+Database+of+Adverse+Human+Effects+using+Fda+Archives%2C+Pharmapendium%2C+and+Public+Sources&rft.au=Ursem%2C+C+J%3BMatthews%2C+E+J%3BKruhlak%2C+N+L%3BBenz%2C+R%3BMacLaughlin%2C+P%3BContrera%2C+J+F&rft.aulast=Ursem&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Restraint Stress Causes Phosphorylation of STAT3 in Liver of C57BL/6J Mice through Activation of Adrenergic Receptors. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555223; 4535842 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Turner, J R AU - Benkovic, S A AU - O'Callaghan, J P AU - Miller, D B Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Stress KW - Mice KW - Liver KW - Adrenergic receptors KW - Stat3 protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Restraint+Stress+Causes+Phosphorylation+of+STAT3+in+Liver+of+C57BL%2F6J+Mice+through+Activation+of+Adrenergic+Receptors.&rft.au=Turner%2C+J+R%3BBenkovic%2C+S+A%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Turner&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profile in Response to Potassium Dichromate-Induced Toxicity in Human Dermal Fibroblasts T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40554861; 4535370 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Joseph, P AU - Umbright, C AU - He, Q. Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Potassium KW - Gene expression KW - Fibroblasts KW - Toxicity KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Gene+Expression+Profile+in+Response+to+Potassium+Dichromate-Induced+Toxicity+in+Human+Dermal+Fibroblasts&rft.au=Joseph%2C+P%3BUmbright%2C+C%3BHe%2C+Q.&rft.aulast=Joseph&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation and Fate of Quantum Dots Following Pulmonary Treatment of Rats T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40554827; 4535903 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Roberts, J R AU - Mercer, R R AU - Young, S AU - Porter, D W AU - Castranova, V AU - Antonini, J M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Rats KW - Lung KW - Inflammation KW - Quantum dots KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Inflammation+and+Fate+of+Quantum+Dots+Following+Pulmonary+Treatment+of+Rats&rft.au=Roberts%2C+J+R%3BMercer%2C+R+R%3BYoung%2C+S%3BPorter%2C+D+W%3BCastranova%2C+V%3BAntonini%2C+J+M&rft.aulast=Roberts&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Thiols and Disulfide Formation in Mercaptobenzothiazole Allergenicity T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40554081; 4535838 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Chipinda, I AU - Hettick, J M AU - Simoyi, R H AU - Zhang, X AU - Siegel1, P. D. Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Thiols KW - Allergenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Role+of+Thiols+and+Disulfide+Formation+in+Mercaptobenzothiazole+Allergenicity&rft.au=Chipinda%2C+I%3BHettick%2C+J+M%3BSimoyi%2C+R+H%3BZhang%2C+X%3BSiegel1%2C+P.+D.&rft.aulast=Chipinda&rft.aufirst=I&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lead (Pb) Effect Levels and Tolerable Levels of Exposure T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40553877; 4536000 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Bolger, P M AU - Carrington, C D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lead KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40553877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Lead+%28Pb%29+Effect+Levels+and+Tolerable+Levels+of+Exposure&rft.au=Bolger%2C+P+M%3BCarrington%2C+C+D&rft.aulast=Bolger&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Improved Method to Prepare Suspensions of Nanoparticles for Treatment of Lung Cells in Culture or In Vivo Exposure by Pharyngeal Aspiration or Intratracheal Instillation. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40553659; 4535912 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Sager, T M AU - Robinson, V A AU - Porter, D W AU - Schwegler-Berry, D AU - Lindsley, W G AU - Castranova, V Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lung KW - Trachea KW - Pharynx KW - Cell culture KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40553659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=An+Improved+Method+to+Prepare+Suspensions+of+Nanoparticles+for+Treatment+of+Lung+Cells+in+Culture+or+In+Vivo+Exposure+by+Pharyngeal+Aspiration+or+Intratracheal+Instillation.&rft.au=Sager%2C+T+M%3BRobinson%2C+V+A%3BPorter%2C+D+W%3BSchwegler-Berry%2C+D%3BLindsley%2C+W+G%3BCastranova%2C+V&rft.aulast=Sager&rft.aufirst=T&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Lung Inflammatory Response Following Pharyngeal Aspiration of Stainless Steel Welding Fume or Soluble Chromium in A/J and C57BL/6J Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40553495; 4535872 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Zeidler-Erdely, P C AU - Young, S AU - Roberts, J R AU - Antonini, J M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lung KW - Welding KW - Steel KW - Fumes KW - Mice KW - Chromium KW - Pharynx KW - Stainless steel KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40553495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Acute+Lung+Inflammatory+Response+Following+Pharyngeal+Aspiration+of+Stainless+Steel+Welding+Fume+or+Soluble+Chromium+in+A%2FJ+and+C57BL%2F6J+Mice&rft.au=Zeidler-Erdely%2C+P+C%3BYoung%2C+S%3BRoberts%2C+J+R%3BAntonini%2C+J+M&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide-Associated Nephro-Toxicity in Juvenile Rats Treated with Gentamicin T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40553324; 4535265 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Espandiari, P AU - Miller, T J AU - Knapton, A AU - Clayton, N P AU - Hanig, J P AU - Zhang, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Rats KW - Gentamicin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40553324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Nitric+Oxide-Associated+Nephro-Toxicity+in+Juvenile+Rats+Treated+with+Gentamicin&rft.au=Espandiari%2C+P%3BMiller%2C+T+J%3BKnapton%2C+A%3BClayton%2C+N+P%3BHanig%2C+J+P%3BZhang%2C+J&rft.aulast=Espandiari&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diesel Exhaust Particle-Induced Oxidant Injury and Cellular Responses in Wild Type and Inducible Nitric Oxide Synthase-Deficient (iNOS KO) Mice: Roles of Particle Core and Adsorbed Organics T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40553265; 4534972 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Ma, J Y AU - Millecchia, L AU - Barger, M AU - Ma, J K AU - Castranova1, V. Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Particulates KW - Oxidants KW - Mice KW - Injuries KW - Exhaust emissions KW - Nitric-oxide synthase KW - Diesel KW - Cores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40553265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Diesel+Exhaust+Particle-Induced+Oxidant+Injury+and+Cellular+Responses+in+Wild+Type+and+Inducible+Nitric+Oxide+Synthase-Deficient+%28iNOS+KO%29+Mice%3A+Roles+of+Particle+Core+and+Adsorbed+Organics&rft.au=Ma%2C+J+Y%3BMillecchia%2C+L%3BBarger%2C+M%3BMa%2C+J+K%3BCastranova1%2C+V.&rft.aulast=Ma&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymph Nodes from Tattooed Mice Exposed to Simulated Solar Light have Sustained Protein Expression Changes T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40552700; 4536007 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Howard, P C AU - Edmondson, R D AU - Jones, R C AU - Thyparambil, S P AU - Taylor, J T AU - Wamer, W G AU - Gopee, N V Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mice KW - Lymph nodes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40552700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Lymph+Nodes+from+Tattooed+Mice+Exposed+to+Simulated+Solar+Light+have+Sustained+Protein+Expression+Changes&rft.au=Howard%2C+P+C%3BEdmondson%2C+R+D%3BJones%2C+R+C%3BThyparambil%2C+S+P%3BTaylor%2C+J+T%3BWamer%2C+W+G%3BGopee%2C+N+V&rft.aulast=Howard&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Prediction and Confirmation of Potential Respiratory Sensitizers Generated from Indoor Air Samples T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40551375; 4535829 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Anderson, S AU - Wells, R AU - Fedorowicz, A AU - Meade, B J AU - Butterworth, L F AU - Munson, A E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Air sampling KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40551375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Prediction+and+Confirmation+of+Potential+Respiratory+Sensitizers+Generated+from+Indoor+Air+Samples&rft.au=Anderson%2C+S%3BWells%2C+R%3BFedorowicz%2C+A%3BMeade%2C+B+J%3BButterworth%2C+L+F%3BMunson%2C+A+E&rft.aulast=Anderson&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Incidence of Cutaneous Melanoma in Tyr-HRAS+ Ink4a/Arf+/- Mice Correlates with Uv-Induced Photodamage in the Anagen Hair Follicle Bulbs of Neonates. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40551024; 4536009 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Tolleson, W H AU - Howard, P C AU - Melchior, W B AU - Muskhelishvili, L AU - Warbritton, A R AU - Latendresse, J R AU - Hay, A AU - Tolleson, A R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Neonates KW - Mice KW - Hair KW - U.V. radiation KW - INK4 protein KW - Bulbs KW - Cyclin-dependent kinase inhibitors KW - Melanoma KW - Follicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40551024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Increased+Incidence+of+Cutaneous+Melanoma+in+Tyr-HRAS%2B+Ink4a%2FArf%2B%2F-+Mice+Correlates+with+Uv-Induced+Photodamage+in+the+Anagen+Hair+Follicle+Bulbs+of+Neonates.&rft.au=Tolleson%2C+W+H%3BHoward%2C+P+C%3BMelchior%2C+W+B%3BMuskhelishvili%2C+L%3BWarbritton%2C+A+R%3BLatendresse%2C+J+R%3BHay%2C+A%3BTolleson%2C+A+R&rft.aulast=Tolleson&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression between Two Sexes in Heart of Rat Strain Fisher 344 T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40550875; 4535972 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Han, T AU - Branham, W AU - Moland, C AU - Holland, R AU - Schnackenberg, L AU - Beger, R AU - Jones, R AU - Edmondson, R AU - Taylor, J AU - Tong, W AU - Dragan, Y P AU - Fuscoe, J C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Gene expression KW - Heart KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Differential+Gene+Expression+between+Two+Sexes+in+Heart+of+Rat+Strain+Fisher+344&rft.au=Han%2C+T%3BBranham%2C+W%3BMoland%2C+C%3BHolland%2C+R%3BSchnackenberg%2C+L%3BBeger%2C+R%3BJones%2C+R%3BEdmondson%2C+R%3BTaylor%2C+J%3BTong%2C+W%3BDragan%2C+Y+P%3BFuscoe%2C+J+C&rft.aulast=Han&rft.aufirst=T&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICCVAM Recommendations on the use of Four In Vitro Test Methods for the Classification of Ocular Corrosives and Severe Irritants T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40550841; 4535955 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Schechtman, L AU - Wind, M AU - Merrill, J AU - Hamernik, K AU - Tice, R AU - Stokes, W Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Corrosion KW - Classification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=ICCVAM+Recommendations+on+the+use+of+Four+In+Vitro+Test+Methods+for+the+Classification+of+Ocular+Corrosives+and+Severe+Irritants&rft.au=Schechtman%2C+L%3BWind%2C+M%3BMerrill%2C+J%3BHamernik%2C+K%3BTice%2C+R%3BStokes%2C+W&rft.aulast=Schechtman&rft.aufirst=L&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Mechanism of Resistance to HIV-1 Peptide Fusion Inhibitors T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40543303; 4528289 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Weiss, Carol D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Peptides KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Novel+Mechanism+of+Resistance+to+HIV-1+Peptide+Fusion+Inhibitors&rft.au=Weiss%2C+Carol+D&rft.aulast=Weiss&rft.aufirst=Carol&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The fallout from asbestos. AN - 70317450; 17382808 JF - Lancet (London, England) AU - Wagner, Gregory R AD - National Institute for Occupational Safety and Health, Washington, DC 20201, USA. gwagner@cdc.gov Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 SP - 973 EP - 974 VL - 369 IS - 9566 KW - Asbestos KW - 1332-21-4 KW - Abridged Index Medicus KW - Index Medicus KW - Global Health KW - Humans KW - Time Factors KW - Asbestosis -- mortality KW - Mesothelioma -- etiology KW - Mesothelioma -- mortality KW - Occupational Exposure -- adverse effects KW - Asbestos -- adverse effects KW - Occupational Exposure -- legislation & jurisprudence KW - Asbestosis -- etiology KW - Occupational Exposure -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70317450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=The+fallout+from+asbestos.&rft.au=Wagner%2C+Gregory+R&rft.aulast=Wagner&rft.aufirst=Gregory&rft.date=2007-03-24&rft.volume=369&rft.issue=9566&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Lancet. 2007 Mar 10;369(9564):844-9 [17350453] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure and mechanism of kainate receptor modulation by anions. AN - 70273741; 17359918 AB - L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors by glutamate requires the presence of both Na(+) and Cl(-) in the extracellular solution, and in the absence of these ions, receptor activity is abolished. Here, we identify the site and mechanism of action of anions. Surprisingly, we find that Cl(-) ions are essential structural components of kainate receptors. Cl(-) ions bind in a cavity formed at the interface between subunits in a dimer pair. In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously. JF - Neuron AU - Plested, Andrew J R AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 829 EP - 841 VL - 53 IS - 6 SN - 0896-6273, 0896-6273 KW - Anions KW - 0 KW - Receptors, Kainic Acid KW - Glutamic Acid KW - 3KX376GY7L KW - Index Medicus KW - Drug Interactions KW - Membrane Potentials -- radiation effects KW - Models, Molecular KW - Crystallography -- methods KW - Humans KW - Mutagenesis -- physiology KW - Glutamic Acid -- pharmacology KW - Structure-Activity Relationship KW - Transfection -- methods KW - Patch-Clamp Techniques KW - Binding Sites -- drug effects KW - Membrane Potentials -- drug effects KW - Cell Line, Transformed KW - Receptors, Kainic Acid -- chemistry KW - Receptors, Kainic Acid -- drug effects KW - Anions -- pharmacology KW - Protein Conformation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70273741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Structure+and+mechanism+of+kainate+receptor+modulation+by+anions.&rft.au=Plested%2C+Andrew+J+R%3BMayer%2C+Mark+L&rft.aulast=Plested&rft.aufirst=Andrew+J&rft.date=2007-03-15&rft.volume=53&rft.issue=6&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2OJT; PDB; 2F34; 2F36 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Community-Onset Methicillin-Resistant Staphylococcus aureus Skin and Soft-Tissue Infections: Impact of Antimicrobial Therapy on Outcome AN - 19524327; 7354622 AB - Background. Conflicting data exist on the role of antimicrobial therapy for the treatment of uncomplicated community-onset methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs). Methods. We performed a retrospective cohort study of 492 adult patients with 531 independent episodes of community-onset MRSA SSTIs, which consisted of abscesses, furuncles/carbuncles, and cellulitis, at 2 tertiary care medical centers. The purpose of the study was to determine the impact of active antimicrobial therapy (i.e., the use of an agent to which the organism is susceptible) and other potential risk factors on the outcome for patients with uncomplicated community-onset MRSA SSTIs. Treatment failure was the primary outcome of interest and was defined as worsening signs of infection associated with microbiological and/or therapeutic indicators of an unsuccessful outcome. Bivariate analyses and logistic regression analyses were preformed to determine predictors of treatment failure. Results. An incision and drainage procedure was performed for the majority of patients. Treatment failure occurred in 45 (8%) of 531 episodes of community-onset MRSA SSTI. Therapy was successful for 296 (95%) of 312 patients who received an active antibiotic, compared with 190 (87%) of 219 of those who did not (P = .001 in bivariate analysis). Use of an inactive antimicrobial agent was an independent predictor of treatment failure on logistic regression analysis (adjusted odds ratio, 2.80; 95% confidence interval, 1.26--6.22; P = .01). Conclusions. Our findings suggest that certain patients with SSTIs that are likely caused by MRSA would benefit from treatment with an antimicrobial agent with activity against this organism. JF - Clinical Infectious Diseases AU - Ruhe, J J AU - Smith, N AU - Bradsher, R W AU - Menon, A AD - Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, and Arkansas Department of Health and Human Services, Little Rock, USA Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 777 EP - 784 VL - 44 IS - 6 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Furuncles KW - Skin KW - Data processing KW - Drug resistance KW - Drainage KW - Antibiotics KW - Infection KW - Abscesses KW - Antimicrobial agents KW - Cellulitis KW - Risk factors KW - Regression analysis KW - Staphylococcus aureus KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19524327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Community-Onset+Methicillin-Resistant+Staphylococcus+aureus+Skin+and+Soft-Tissue+Infections%3A+Impact+of+Antimicrobial+Therapy+on+Outcome&rft.au=Ruhe%2C+J+J%3BSmith%2C+N%3BBradsher%2C+R+W%3BMenon%2C+A&rft.aulast=Ruhe&rft.aufirst=J&rft.date=2007-03-15&rft.volume=44&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Furuncles; Cellulitis; Data processing; Skin; Risk factors; Drainage; Drug resistance; Regression analysis; Antibiotics; Abscesses; Infection; Antimicrobial agents; Staphylococcus aureus ER - TY - JOUR T1 - Validation of an in vitro method for the determination of cyanide release from ferric-hexacyanoferrate: Prussian blue. AN - 70198885; 17174056 AB - Prussian blue (PB), ferric hexacyanoferrate, Fe(4)[Fe(CN)(6)](3) is indicated for the treatment of known or suspected internal contamination with radioactive cesium, radioactive thallium, or non-radioactive thallium. Owing to the molecular properties, cyanide is likely dissociated from PB under physiologically relevant pH conditions, thus raising a concern for the safety of the product. The objective of this study was to calibrate and validate a cyanide assay over a wide pH range (from 0.5 to 12) on the basis of Spectroquant cyanide test method (Merck). Merck's photometric method requires that the measurement solution be within pH 5.5-6.0, hence samples and standards need to be adjusted to this pH range. Since the process of pH adjustment may have significant impact on the determination of cyanide, the analysis method needs to be optimized, calibrated and validated under each pH condition in the study. The validation characteristics included accuracy, precision, quantification limit, linearity, and stability. The intra-day accuracy ranged from 90% to 109% for the deionized water and solutions of pH 0.5-12. The intra-day precision (R.S.D.) ranged from 2.4% to 8.1% for the deionized water and solutions of pH 0.5-12. The analytical range was linear from 0.05 to 0.5 ppm (mg/L). The R(2) ranged from 0.9925 to 0.9998. This validated method was successfully implemented to determine cyanide release from PB under various pH conditions (from 1.0 to 12) at different time-points (from 1 to 24 h). JF - Journal of pharmaceutical and biomedical analysis AU - Yang, Yongsheng AU - Brownell, Charles R AU - Sadrieh, Nakissa AU - May, Joan C AU - Del Grosso, Alfred V AU - Lyon, Robbe C AU - Faustino, Patrick J AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research, Silver Spring, MD 20993, USA. Y1 - 2007/03/12/ PY - 2007 DA - 2007 Mar 12 SP - 1358 EP - 1363 VL - 43 IS - 4 SN - 0731-7085, 0731-7085 KW - Cyanides KW - 0 KW - Ferrocyanides KW - Reagent Kits, Diagnostic KW - Hydrogen Cyanide KW - 2WTB3V159F KW - ferric ferrocyanide KW - TLE294X33A KW - Index Medicus KW - Reproducibility of Results KW - Kinetics KW - Hydrogen-Ion Concentration KW - Reference Standards KW - In Vitro Techniques KW - Cyanides -- chemistry KW - Hydrogen Cyanide -- chemistry KW - Ferrocyanides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70198885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+and+biomedical+analysis&rft.atitle=Validation+of+an+in+vitro+method+for+the+determination+of+cyanide+release+from+ferric-hexacyanoferrate%3A+Prussian+blue.&rft.au=Yang%2C+Yongsheng%3BBrownell%2C+Charles+R%3BSadrieh%2C+Nakissa%3BMay%2C+Joan+C%3BDel+Grosso%2C+Alfred+V%3BLyon%2C+Robbe+C%3BFaustino%2C+Patrick+J&rft.aulast=Yang&rft.aufirst=Yongsheng&rft.date=2007-03-12&rft.volume=43&rft.issue=4&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+and+biomedical+analysis&rft.issn=07317085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-25 N1 - Date created - 2007-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Degradation of indulin, a kraft pine lignin, by Serratia marcescens AN - 856764804; 13897104 AB - Serratia marcescens isolated from decaying coconut pith exhibited high lignolytic activity. Growth on indicator medium, analysis of residual indulin, and infra-red spectroscopic analysis indicated the lignolytic potential of the isolate. Ortho-Coumaric acid, ferulic acid, 2,3-dihydroxy cinnamic acid and protocatechuic acid were identified as intermediates involved in indulin degradation by S. marcescens. Qualitative confirmation and quantitative estimation of the intermediates were carried out by high performance thin layer chromatography (HPTLC). JF - Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes AU - Manangeeswaran, Mohanraj AU - Ramalingam, Vijayanandraj V AU - Kumar, Karthik AU - Mohan, Natarajan AD - Centre for advanced studies in Botany, University of Madras, Chennai, India,United States Food and Drug Administration, National Institutes of Health, Bethesda, Washington, D.C., USA Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 321 EP - 327 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 42 IS - 3 SN - 0360-1234, 0360-1234 KW - Environment Abstracts; Water Resources Abstracts KW - Indulin degradation KW - Lignolytic activity KW - Lignin degrading bacteria KW - Serratia marcescens KW - Degradation KW - Chromatography KW - Agricultural wastes KW - Indicators KW - Serratia KW - Agricultural Chemicals KW - Pollutants KW - Acids KW - Pesticides KW - Farm Wastes KW - Thin Layer Chromatography KW - SW 3050:Ultimate disposal of wastes KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856764804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+B%3A+Pesticides%2C+Food+Contaminants+and+Agricultural+Wastes&rft.atitle=Degradation+of+indulin%2C+a+kraft+pine+lignin%2C+by+Serratia+marcescens&rft.au=Manangeeswaran%2C+Mohanraj%3BRamalingam%2C+Vijayanandraj+V%3BKumar%2C+Karthik%3BMohan%2C+Natarajan&rft.aulast=Manangeeswaran&rft.aufirst=Mohanraj&rft.date=2007-03-01&rft.volume=42&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+B%3A+Pesticides%2C+Food+Contaminants+and+Agricultural+Wastes&rft.issn=03601234&rft_id=info:doi/10.1080%2F03601230701229320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Number of references - 32 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Degradation; Chromatography; Agricultural wastes; Pesticides; Serratia; Agricultural Chemicals; Pollutants; Acids; Indicators; Farm Wastes; Thin Layer Chromatography; Serratia marcescens DO - http://dx.doi.org/10.1080/03601230701229320 ER - TY - JOUR T1 - Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp AN - 754568148; 13416714 AB - Mycobacterium sp. 7E1B1W and seven other mycobacterial strains known to degrade hydrocarbons were investigated to determine their ability to metabolize the piperazine ring, a substructure found in many drugs. Cultures were grown at 30C in tryptic soy broth and dosed with 3.1mM N-phenylpiperazine hydrochloride; samples were removed at intervals and extracted with ethyl acetate. Two metabolites were purified from each of the extracts by high-performance liquid chromatography; they were identified by mass spectrometry and super(1)H nuclear magnetic resonance spectroscopy as N-(2-anilinoethyl)acetamide and N-acetyl-N'-phenylpiperazi ne. The results show that mycobacteria have the ability to acetylate piperazine rings and cleave carbon-nitrogen bonds. JF - Journal of Industrial Microbiology & Biotechnology AU - Adjei, MD AU - Deck, J AU - Heinze, T M AU - Freeman, J P AU - Williams, A J AU - Sutherland, J B AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, john.sutherland@fda.hhs.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 219 EP - 224 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 34 IS - 3 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - Mycobacterium KW - Hydrocarbons KW - Ethyl acetate KW - piperazine KW - Metabolites KW - N.M.R. KW - Spectroscopy KW - Drugs KW - Mass spectroscopy KW - Soybeans KW - A 01340:Antibiotics & Antimicrobials KW - K 03330:Biochemistry KW - W 30910:Imaging KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754568148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=Identification+of+metabolites+produced+from+N-phenylpiperazine+by+Mycobacterium+spp&rft.au=Adjei%2C+MD%3BDeck%2C+J%3BHeinze%2C+T+M%3BFreeman%2C+J+P%3BWilliams%2C+A+J%3BSutherland%2C+J+B&rft.aulast=Adjei&rft.aufirst=MD&rft.date=2007-03-01&rft.volume=34&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-006-0189-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Hydrocarbons; Ethyl acetate; piperazine; N.M.R.; Metabolites; Spectroscopy; Drugs; Mass spectroscopy; Soybeans; Mycobacterium DO - http://dx.doi.org/10.1007/s10295-006-0189-x ER - TY - JOUR T1 - Large outbreaks of Salmonella Typhimurium phage type 135 infections associated with the consumption of products containing raw egg in Tasmania. AN - 70501254; 17503652 AB - This report describes one of the largest egg-associated outbreaks of foodborne illness in Australia for many years. Between June and December 2005, five outbreaks of Salmonella Typhimurium phage type 135 were identified in Tasmania, leading to 125 laboratory-confirmed cases. Public health investigations included case and food handler interviews, cohort studies, environmental health investigations of food businesses, microbiological testing, traceback, and inspections and drag swabbing of an egg farm. These investigations enabled identification of foods containing raw egg or foods contaminated through inadequate food handling and/or storage procedures as possible vehicles for infection. A particular poultry farm was reported as the common source of eggs. Interventions targeting the general public and food handlers to promote better handling of egg products, and advice to egg producers regarding harm minimisation strategies led to the series of outbreaks being brought under control. JF - Communicable diseases intelligence quarterly report AU - Stephens, Nicola AU - Sault, Cameron AU - Firestone, Simon M AU - Lightfoot, Diane AU - Bell, Cameron AD - Communicable Disease Prevention Unit, Department of Health and Human Services, Hobart, Tasmania. nicola.stephens@dhhs.tas.gov.au Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 118 EP - 124 VL - 31 IS - 1 SN - 1447-4514, 1447-4514 KW - Index Medicus KW - Tasmania -- epidemiology KW - Humans KW - Cooking KW - Food Contamination KW - Time Factors KW - Food Microbiology KW - Eggs -- microbiology KW - Salmonella typhimurium -- isolation & purification KW - Salmonella Food Poisoning -- epidemiology KW - Salmonella Food Poisoning -- microbiology KW - Disease Outbreaks KW - Salmonella typhimurium -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70501254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Communicable+diseases+intelligence+quarterly+report&rft.atitle=Large+outbreaks+of+Salmonella+Typhimurium+phage+type+135+infections+associated+with+the+consumption+of+products+containing+raw+egg+in+Tasmania.&rft.au=Stephens%2C+Nicola%3BSault%2C+Cameron%3BFirestone%2C+Simon+M%3BLightfoot%2C+Diane%3BBell%2C+Cameron&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2007-03-01&rft.volume=31&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Communicable+diseases+intelligence+quarterly+report&rft.issn=14474514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2007-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurologic symptoms in licensed pesticide applicators in the Agricultural Health Study. AN - 70388012; 17439927 AB - Exposure to high levels of many pesticides has both acute and long-term neurologic consequences, but little is known about the neurotoxicity of chronic exposure to moderate pesticide levels. We analysed cross-sectional data from 18 782 Caucasian, male, licensed pesticide applicators, enrolled in the Agricultural Health Study from 1993 to 1997. Applicators provided information on lifetime pesticide use, and 23 neurologic symptoms typically associated with pesticide intoxication. Increased risk of experiencing >/=10 symptoms during the year before enrollment was associated with cumulative pesticide use, personally mixing or applying pesticides, pesticide-related medical care, diagnosed pesticide poisoning, and events involving high personal pesticide exposure. Greatest risk was associated with use of organophosphate and organochlorine insecticides. Results were similar after stratification by pesticide use during the year before enrollment, or exclusion of applicators with a history of pesticide poisoning, or high-exposure events. Use of pesticide application methods likely to involve high personal exposure was associated with greater risk. Groups of symptoms reflecting several neurologic domains, including affect, cognition, autonomic and motor function, and vision, were also associated with pesticide exposure. These results suggest that neurologic symptoms are associated with cumulative exposure to moderate levels of organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning. JF - Human & experimental toxicology AU - Kamel, F AU - Engel, L S AU - Gladen, B C AU - Hoppin, J A AU - Alavanja, M C R AU - Sandler, D P AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA. kamel@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 243 EP - 250 VL - 26 IS - 3 SN - 0960-3271, 0960-3271 KW - Hydrocarbons, Chlorinated KW - 0 KW - Organophosphorus Compounds KW - Pesticides KW - Index Medicus KW - Agriculture KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - North Carolina -- epidemiology KW - Adolescent KW - Male KW - Iowa -- epidemiology KW - Nervous System Diseases -- epidemiology KW - Hydrocarbons, Chlorinated -- toxicity KW - Organophosphorus Compounds -- toxicity KW - Occupational Exposure -- adverse effects KW - Nervous System Diseases -- chemically induced KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70388012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Neurologic+symptoms+in+licensed+pesticide+applicators+in+the+Agricultural+Health+Study.&rft.au=Kamel%2C+F%3BEngel%2C+L+S%3BGladen%2C+B+C%3BHoppin%2C+J+A%3BAlavanja%2C+M+C+R%3BSandler%2C+D+P&rft.aulast=Kamel&rft.aufirst=F&rft.date=2007-03-01&rft.volume=26&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-18 N1 - Date created - 2007-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. AN - 70373308; 17431502 AB - We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults. JF - Environmental health perspectives AU - Shih, Regina A AU - Hu, Howard AU - Weisskopf, Marc G AU - Schwartz, Brian S AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 483 EP - 492 VL - 115 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Humans KW - Adult KW - Bone and Bones -- metabolism KW - Environmental Pollutants -- toxicity KW - Cognition -- drug effects KW - Lead -- toxicity KW - Environmental Pollutants -- analysis KW - Lead -- analysis KW - Environmental Pollutants -- blood KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cumulative+lead+dose+and+cognitive+function+in+adults%3A+a+review+of+studies+that+measured+both+blood+lead+and+bone+lead.&rft.au=Shih%2C+Regina+A%3BHu%2C+Howard%3BWeisskopf%2C+Marc+G%3BSchwartz%2C+Brian+S&rft.aulast=Shih&rft.aufirst=Regina&rft.date=2007-03-01&rft.volume=115&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-14 N1 - Date created - 2007-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Mar;108(3):239-42 [10706530] Gerontology. 2000 Jul-Aug;46(4):219-27 [10859462] Neurotoxicology. 2000 Jun;21(3):365-78 [10894126] Neurology. 2000 Jul 12;55(1):134-6 [10891924] Neurology. 2000 Oct 24;55(8):1144-50 [11071492] Neurotoxicology. 2000 Oct;21(5):805-11 [11130286] Am J Epidemiol. 2001 Mar 1;153(5):453-64 [11226977] Neurotoxicology. 2000 Dec;21(6):1069-80 [11233753] Environ Health Perspect. 2001 Apr;109(4):361-8 [11335184] Toxicol Lett. 2001 Sep 15;123(2-3):195-207 [11641047] Arch Toxicol. 2001 Sep;75(7):439-42 [11693185] Behav Brain Res. 2001 Dec 14;127(1-2):199-207 [11718892] Occup Environ Med. 2002 Apr;59(4):217-23 [11934948] Arch Toxicol. 2002 Apr;76(3):137-45 [11967618] Environ Health Perspect. 2002 May;110(5):501-5 [12003753] Arch Neurol. 2002 May;59(5):787-93 [12020261] Psychol Aging. 2002 Jun;17(2):179-93 [12061405] Int Arch Occup Environ Health. 2002 Aug;75(6):394-8 [12070635] Occup Environ Med. 2002 Sep;59(9):648-9 [12205243] Epidemiology. 2003 Jan;14(1):30-6 [12500043] Occup Environ Med. 2003 Feb;60(2):145; 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AN - 70336453; 17405901 AB - On June 20, 2006, the U.S. Food and Drug Administration (FDA) approved bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA), administered in combination with FOLFOX4 (5-fluorouracil, leucovorin, and oxaliplatin) for the second-line treatment of metastatic carcinoma of the colon or rectum. Efficacy and safety were demonstrated in one Eastern Cooperative Oncology Group (ECOG) open-label, multicenter, randomized, three-arm, active-controlled trial enrolling 829 adult patients. Patients had received a fluoropyrimidine- and irinotecan-based regimen as initial therapy for metastatic disease; or they had received prior adjuvant irinotecan-based chemotherapy and had recurred within 6 months of completing therapy. Treatments included bevacizumab, 10 mg/kg, as a 90-minute i.v. infusion on day 1, every 2 weeks, either alone or in combination with FOLFOX4, or FOLFOX4 alone. The bevacizumab monotherapy arm was closed to accrual after an interim efficacy analysis suggested a possibly shorter survival in that arm. Overall survival (OS), the primary study endpoint, was significantly longer for patients receiving bevacizumab in combination with FOLFOX4 than for those receiving FOLFOX4 alone. The objective response rate was significantly higher in the FOLFOX4 plus bevacizumab arm than in the FOLFOX4 alone arm. The duration of response was approximately 6 months for both treatment arms. Patients treated with the bevacizumab combination were also reported, based on investigator assessment, to have significantly longer progression-free survival. There were no new bevacizumab safety signals. The most serious, and sometimes fatal, bevacizumab toxicities are gastrointestinal perforation, wound-healing complications, hemorrhage, arterial thromboembolic events, hypertensive crisis, nephrotic syndrome, and congestive heart failure. JF - The oncologist AU - Cohen, Martin H AU - Gootenberg, Joe AU - Keegan, Patricia AU - Pazdur, Richard AD - Division of Biological Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, HFD-150, 5600 Fishers Lane, Rockville, Maryland 20857, USA. cohenma@cder.fda.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 356 EP - 361 VL - 12 IS - 3 SN - 1083-7159, 1083-7159 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - United States KW - Organoplatinum Compounds -- administration & dosage KW - Infusions, Intravenous KW - Injections, Intravenous KW - Leucovorin -- administration & dosage KW - Humans KW - Aged KW - Antibodies, Monoclonal -- administration & dosage KW - Fluorouracil -- administration & dosage KW - United States Food and Drug Administration KW - Drug Approval KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Antibodies, Monoclonal -- adverse effects KW - Male KW - Female KW - Survival Analysis KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70336453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+bevacizumab+plus+FOLFOX4+as+second-line+treatment+of+colorectal+cancer.&rft.au=Cohen%2C+Martin+H%3BGootenberg%2C+Joe%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2007-03-01&rft.volume=12&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental and behavioral factors and the risk of non-Hodgkin lymphoma. AN - 70282759; 17344463 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hartge, Patricia AU - Smith, Martyn T AD - National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. hartge@nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 367 EP - 368 VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Epidemiologic Studies KW - Sunlight -- adverse effects KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - Occupations KW - Life Style KW - Environment KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Environmental+and+behavioral+factors+and+the+risk+of+non-Hodgkin+lymphoma.&rft.au=Hartge%2C+Patricia%3BSmith%2C+Martyn+T&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Results from a state-based surveillance system for carbon monoxide poisoning. AN - 70269941; 17357356 AB - OBJECTIVES The purpose of this study was to describe results from a pilot surveillance system for carbon monoxide poisoning--a significant yet preventable public health issue for which most public health agencies do not conduct routine public health surveillance. METHODS The authors developed a rate-based statewide surveillance system. Cases were identified using the 1998 Council of State and Territorial Epidemiologists' case definition in hospital discharges, emergency department and hospital outpatient visits, and mortality data. Intentional and fire-related injuries were excluded. The system was supplemented with qualitative information from newspaper articles. Annual, age, and sex-specific incidence rates were estimated. Exposure source/setting was described using E-codes; occupational setting was assessed by combining E-codes and payer code. Cases occurring during a disaster-related power outage in January 1998 were compared with cases identified during routine surveillance from 1999 through 2003. RESULTS During the five years of routine surveillance, 740 cases were identified; 47 (6.4%) were hospitalized, 442 (59.7%) were seen in an emergency department, and 251 (34.3%) were seen in another outpatient setting. More cases were observed in fall/winter; 23.1% of patients aged 16 or older were classified as exposed in an occupational setting. Among disaster-related cases, more were older (> or =65 years of age; 11.9% vs. 4.2%) and female (61.6% vs. 45.3%); and fewer were in occupational settings (1.8% vs. 23.1%). CONCLUSIONS Establishing state-based public health surveillance for CO poisoning is feasible and essential for guiding prevention and control efforts. The finding that more than 20% of cases were classified as occupational should be investigated further. JF - Public health reports (Washington, D.C. : 1974) AU - Graber, Judith M AU - Smith, Andrew E AD - Environmental and Occupational Health Unit, Center for Disease Control and Prevention, Maine Department of Health and Human Services, 286 Water St., SHS 11, Augusta ME 04333, USA. PY - 2007 SP - 145 EP - 154 VL - 122 IS - 2 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - Maine -- epidemiology KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Feasibility Studies KW - Aged, 80 and over KW - Adult KW - Program Development KW - Program Evaluation KW - Middle Aged KW - Adolescent KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - State Government KW - Public Health Administration KW - Environmental Exposure -- adverse effects KW - Carbon Monoxide Poisoning -- epidemiology KW - Carbon Monoxide Poisoning -- prevention & control KW - Public Health Informatics KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Results+from+a+state-based+surveillance+system+for+carbon+monoxide+poisoning.&rft.au=Graber%2C+Judith+M%3BSmith%2C+Andrew+E&rft.aulast=Graber&rft.aufirst=Judith&rft.date=2007-03-01&rft.volume=122&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-09 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Comput Biol Med. 1992 Sep;22(5):351-61 [1424580] MMWR Morb Mortal Wkly Rep. 1999 Aug 20;48(32):705-6 [21033180] MMWR Morb Mortal Wkly Rep. 1993 Sep 3;42(34):653-6 [8350858] MMWR Morb Mortal Wkly Rep. 1993 Oct 15;42(40):777-9, 785 [8413163] MMWR Morb Mortal Wkly Rep. 1994 Jan 21;43(2):21-3 [7506348] MMWR Morb Mortal Wkly Rep. 1995 May 12;44(18):356-7, 363-4 [7731452] MMWR Morb Mortal Wkly Rep. 1995 Oct 20;44(41):765-7 [7565559] West J Med. 1995 Nov;163(5):431-4 [8533404] MMWR Morb Mortal Wkly Rep. 1996 Jan 19;45(2):32-8 [8531918] MMWR Morb Mortal Wkly Rep. 1996 Apr 5;45(13):265-7 [8596526] J Emerg Med. 1997 Jul-Aug;15(4):469-73 [9279697] MMWR Morb Mortal Wkly Rep. 1997 Dec 26;46(51):1221-4 [9427213] MMWR Morb Mortal Wkly Rep. 1997 Dec 26;46(51):1224-7 [9427214] JAMA. 1998 Mar 4;279(9):685-7 [9496987] West J Med. 1998 Mar;168(3):158-65 [9549414] J Occup Environ Med. 1998 Apr;40(4):325-31 [9571523] J Emerg Med. 2000 Jan;18(1):87-93 [10645845] MMWR Morb Mortal Wkly Rep. 2000 May 5;49(17):369-72 [10821481] Arch Environ Health. 2000 Nov-Dec;55(6):375-81 [11128873] JAMA. 2002 Aug 28;288(8):988-95 [12190369] MMWR Morb Mortal Wkly Rep. 2002 Sep 20;51(37):829-30 [12353743] MMWR Morb Mortal Wkly Rep. 2004 Apr 23;53(15):314-8 [15103294] MMWR Morb Mortal Wkly Rep. 2004 Sep 17;53(36):835-7 [15371963] JAMA. 1991 Aug 7;266(5):659-63 [1712865] MMWR Morb Mortal Wkly Rep. 1998 Oct 30;47(42):897-8 [9810013] N Engl J Med. 1998 Nov 26;339(22):1603-8 [9828249] MMWR Morb Mortal Wkly Rep. 2005 Jan 21;54(2):36-9 [15660017] MMWR Morb Mortal Wkly Rep. 2005 Jul 22;54(28):693-7 [16034314] MMWR Morb Mortal Wkly Rep. 2005 Jul 22;54(28):697-700 [16034315] MMWR Morb Mortal Wkly Rep. 2005 Oct 7;54(39):996-8 [16208314] Am J Emerg Med. 2005 Nov;23(7):838-41 [16291437] WMJ. 2006 Mar;105(2):36-40 [16628973] MMWR Morb Mortal Wkly Rep. 1992 Nov 27;41(47):881-3, 889 [1279372] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Acute pesticide poisoning in the U.S. retail industry, 1998-2004. AN - 70269369; 17357366 AB - OBJECTIVE This study was conducted to describe the national magnitude and characteristics of acute pesticide poisoning among workers and customers in retail establishments. METHODS Analyses included retail employees 15-64 years of age and customers with acute pesticide poisoning identified from the Sentinel Event Notification System for Occupational Risks-Pesticides (SENSOR-Pesticides) and California Department of Pesticide Regulation from 1998 to 2004. Pesticide poisoning incidence rates and incidence rate ratios (IRR) were calculated. RESULTS A total of 325 cases of acute pesticide poisoning were identified. Of these cases, 287 (88%) were retail employees and 38 (12%) were customers. Overall, retail employees had a significantly lower acute pesticide poisoning incidence rate compared with non-agricultural, non-retail employees (IRR=0.53; 95% confidence interval 0.47, 0.59). However, significantly elevated pesticide poisoning incidence rates were observed for four retail occupations (janitors, stock handlers/baggers, bakery/deli clerks, and shipping/receiving handlers). In addition, workers employed in two retail industry sectors (farm supply stores and hardware stores) had significantly elevated acute pesticide poisoning incidence rates. Incidence rates among the retail employees demonstrated a quadratic trend, monotonically decreasing from 1998 to 2000 and monotonically increasing from 2000 to 2003. The rates appear to have leveled off in 2003 and 2004. CONCLUSIONS Preventive measures to decrease acute pesticide poisoning incidence in the retail sector include adoption of unbreakable and tear-resistant container requirements, increased utilization of integrated pest management strategies, and advisement to store managers, employees, and customers about poisoning prevention. JF - Public health reports (Washington, D.C. : 1974) AU - Calvert, Geoffrey M AU - Petersen, Ann M AU - Sievert, Jennifer AU - Mehler, Louise N AU - Das, Rupali AU - Harter, Lucy C AU - Romioli, Cinzia AU - Becker, Alan AU - Ball, Cynthia AU - Male, Dorilee AU - Schwartz, Abby AU - Lackovic, Michelle AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. jac6@cdc.gov PY - 2007 SP - 232 EP - 244 VL - 122 IS - 2 SN - 0033-3549, 0033-3549 KW - Organophosphates KW - 0 KW - Pesticides KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Humans KW - Population Surveillance KW - Risk Factors KW - Adult KW - Food Contamination -- statistics & numerical data KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Organophosphates -- supply & distribution KW - Occupational Exposure -- statistics & numerical data KW - Commerce -- statistics & numerical data KW - Product Packaging -- standards KW - Organophosphate Poisoning KW - Pesticides -- poisoning KW - Occupational Exposure -- adverse effects KW - Pesticides -- supply & distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Acute+pesticide+poisoning+in+the+U.S.+retail+industry%2C+1998-2004.&rft.au=Calvert%2C+Geoffrey+M%3BPetersen%2C+Ann+M%3BSievert%2C+Jennifer%3BMehler%2C+Louise+N%3BDas%2C+Rupali%3BHarter%2C+Lucy+C%3BRomioli%2C+Cinzia%3BBecker%2C+Alan%3BBall%2C+Cynthia%3BMale%2C+Dorilee%3BSchwartz%2C+Abby%3BLackovic%2C+Michelle&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2007-03-01&rft.volume=122&rft.issue=2&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-09 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Vet Hum Toxicol. 1988 Jun;30(3):246-54 [3291386] Am J Ind Med. 2004 Jan;45(1):14-23 [14691965] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Risk minimization practices for pregnancy prevention: understanding risk, selecting tools. AN - 70245980; 16953517 AB - According to the March of Dimes, approximately 4% (1/28) of babies are born in the US each year with a birth defect. For the majority of birth defects the etiology is unknown, although chemicals, including drug exposures, probably account for less than 1% of all birth defects. The identification of potential human teratogenicity during drug development is important because drug-induced adverse fetal effects are potentially preventable with the application of risk assessment strategies and risk minimization tools and programs to minimize risk of pregnancy exposure while preserving access to drug benefits; risk assessment and risk minimization together comprise risk management. It is important that risk minimization programs intended to limit fetal exposure use a consistent approach and are tailored to the product-specific risk concerns in order to optimize the benefit-risk balance for a particular drug. This paper highlights general considerations in developing specific risk minimization programs to prevent fetal drug exposure including the relative advantages and disadvantages of each strategy. (c) 2007 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - Uhl, Kathleen AU - Trontell, Anne AU - Kennedy, Dianne AD - US Food and Drug Administration, Office of Women's Health, Rockville, MD 20857, USA. kathleen.uhl@fda.hhs.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 337 EP - 348 VL - 16 IS - 3 SN - 1053-8569, 1053-8569 KW - Teratogens KW - 0 KW - Index Medicus KW - Practice Patterns, Physicians' KW - Patient Education as Topic KW - Contraception KW - Humans KW - Infant, Newborn KW - Drug Labeling KW - Female KW - Risk Assessment KW - Pregnancy KW - Pregnancy Complications -- prevention & control KW - Drug-Related Side Effects and Adverse Reactions KW - Pregnancy Complications -- chemically induced KW - Risk Management KW - Abnormalities, Drug-Induced -- etiology KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70245980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Risk+minimization+practices+for+pregnancy+prevention%3A+understanding+risk%2C+selecting+tools.&rft.au=Uhl%2C+Kathleen%3BTrontell%2C+Anne%3BKennedy%2C+Dianne&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications. AN - 70232765; 17341233 AB - To determine whether resident and facility characteristics and prescription medications influence the occurrence of fractures in nursing homes (NHs). Panel study with 1-year follow-up. A nationally representative sample of NHs from the Medical Expenditure Panel Survey (MEPS). Residents aged 65 and older who were in sample NHs on January 1, 1996. Health status measures were collected from facility records and abstracted using a computer-assisted personal interview instrument. Fracture and drug data were updated every 4 months to provide a full year of information. Drug data were obtained from monthly medication administration records. The occurrences of fractures were obtained from medical records. Administered medications were classified using the Department of Veterans Affairs medication classification system. Facility characteristics were based on MEPS survey data collected from NH sources. In 1996, 6% of residents in a NH at the beginning of the year experienced a fracture during their NH stay(s). Resident risk factors included aged 85 and older, admitted from the community, exhibited agitated behaviors, and used both wheelchair and cane or walker. Use of anticonvulsants, antidepressants, opioid analgesics, iron supplements, bisphosphonates, thiazides, and laxatives were associated with fractures. A high certified nurse aide ratio was negatively associated with fractures. The findings indicate that fractures are associated with resident and facility characteristics and prescribing practices. It reaffirms the importance of medication review with special attention on opioid analgesics, antidepressants, and anticonvulsants to reduce the risk of fractures. JF - Journal of the American Geriatrics Society AU - Spector, William AU - Shaffer, Thomas AU - Potter, D E B AU - Correa-de-Araujo, Rosaly AU - Rhona Limcangco, M AD - Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. William.Spector@ahrq.hhs.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 327 EP - 333 VL - 55 IS - 3 SN - 0002-8614, 0002-8614 KW - Cathartics KW - 0 KW - Diphosphonates KW - Iron Compounds KW - Psychotropic Drugs KW - Sodium Chloride Symporter Inhibitors KW - Index Medicus KW - United States KW - Mobility Limitation KW - Cathartics -- administration & dosage KW - Cathartics -- adverse effects KW - Diphosphonates -- adverse effects KW - Sodium Chloride Symporter Inhibitors -- administration & dosage KW - Humans KW - Aged KW - Iron Compounds -- adverse effects KW - Cross-Sectional Studies KW - Sodium Chloride Symporter Inhibitors -- adverse effects KW - Aged, 80 and over KW - Risk Factors KW - Nurses' Aides -- supply & distribution KW - Diphosphonates -- administration & dosage KW - Health Surveys KW - Iron Compounds -- administration & dosage KW - Statistics as Topic KW - Geriatric Assessment -- statistics & numerical data KW - Male KW - Female KW - Fractures, Bone -- epidemiology KW - Homes for the Aged -- statistics & numerical data KW - Drug-Related Side Effects and Adverse Reactions KW - Fractures, Bone -- etiology KW - Nursing Homes -- statistics & numerical data KW - Psychotropic Drugs -- adverse effects KW - Psychotropic Drugs -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70232765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Risk+factors+associated+with+the+occurrence+of+fractures+in+U.S.+nursing+homes%3A+resident+and+facility+characteristics+and+prescription+medications.&rft.au=Spector%2C+William%3BShaffer%2C+Thomas%3BPotter%2C+D+E+B%3BCorrea-de-Araujo%2C+Rosaly%3BRhona+Limcangco%2C+M&rft.aulast=Spector&rft.aufirst=William&rft.date=2007-03-01&rft.volume=55&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Geriatr Soc. 2007 Mar;55(3):464-6 [17341253] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. AN - 70222585; 17219426 AB - Tamoxifen, a nonsteroidal anti-estrogen, is a potent genotoxic hepatocarcinogen in rats, with both tumor initiating and promoting properties. Recently it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations and these induced epigenetic changes may play important mechanistic role in carcinogenesis. In the present study, we investigated the role of tamoxifen-induced epigenetic changes in hepatocarcinogenic process. The results of the study showed that exposure of female F344 rats to tamoxifen resulted in progressive loss of CpG methylation in regulatory sequences of long interspersed nucleotide elements (LINE-1) and prominent increase in expression of LINE-1 elements and c-myc proto-oncogene. The accumulation of tamoxifen-induced DNA lesions was accompanied by the decreased level of Rad51, Ku70, and DNA polymerase beta (Polbeta) proteins that play a crucial role in maintenance of genomic stability. Furthermore, feeding rats with tamoxifen-containing diet led to increased regenerative cell proliferation, as indicated by the increased level of Ki-67 and proliferating cell nuclear antigen (PCNA) proteins. These data indicate that exposure of animals to genotoxic hepatocarcinogen tamoxifen led to early phenotypical alterations in livers characterized by emergence of epigenetically reprogrammed cells with a specific cancer-related epigenetic phenotype prior to tumor formation. (c) 2006 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Tryndyak, Volodymyr P AU - Kovalchuk, Olga AU - Muskhelishvili, Levan AU - Montgomery, Beverly AU - Rodriguez-Juarez, Rocio AU - Melnyk, Stepan AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 187 EP - 197 VL - 46 IS - 3 SN - 0899-1987, 0899-1987 KW - Antigens, Nuclear KW - 0 KW - DNA-Binding Proteins KW - Estrogen Antagonists KW - RNA, Messenger KW - Tamoxifen KW - 094ZI81Y45 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Rad51 Recombinase KW - Rad51 protein, rat KW - Xrcc6 protein, rat KW - EC 3.6.4.12 KW - Ku Autoantigen KW - EC 4.2.99.- KW - Index Medicus KW - Animals KW - DNA Polymerase beta -- genetics KW - DNA-Binding Proteins -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Antigens, Nuclear -- genetics KW - DNA Polymerase beta -- metabolism KW - Rats KW - Rats, Inbred F344 KW - Rad51 Recombinase -- metabolism KW - RNA, Messenger -- metabolism KW - Antigens, Nuclear -- metabolism KW - DNA Methylation KW - CpG Islands KW - Rad51 Recombinase -- genetics KW - Female KW - Immunoenzyme Techniques KW - Long Interspersed Nucleotide Elements -- genetics KW - DNA-Binding Proteins -- metabolism KW - Tamoxifen -- toxicity KW - Estrogen Antagonists -- toxicity KW - Liver Neoplasms, Experimental -- genetics KW - Liver Neoplasms -- pathology KW - Hepatocytes -- drug effects KW - Liver Neoplasms -- drug therapy KW - Epigenesis, Genetic -- drug effects KW - Liver Neoplasms, Experimental -- chemically induced KW - Liver Neoplasms -- etiology KW - Cell Transformation, Neoplastic KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70222585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Epigenetic+reprogramming+of+liver+cells+in+tamoxifen-induced+rat+hepatocarcinogenesis.&rft.au=Tryndyak%2C+Volodymyr+P%3BKovalchuk%2C+Olga%3BMuskhelishvili%2C+Levan%3BMontgomery%2C+Beverly%3BRodriguez-Juarez%2C+Rocio%3BMelnyk%2C+Stepan%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2007-03-01&rft.volume=46&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of birth defects according to maternal therapy among infants in the Women and Infants Transmission Study. AN - 70221585; 17159659 AB - To evaluate rate and types of birth defects according to timing of antiretroviral exposure among babies born to HIV-infected women. Anomalies identified during the prenatal, neonatal, or follow-up period were classified using criteria of the Antiretroviral Pregnancy Registry. Antiretroviral use was classified as none, second or third trimester only, or first trimester. From January 1, 1990 through June 30, 2004, 2527 live births (LBs) occurred to 2353 women. Defects were identified in 90 babies for a rate of 3.56 defects per 100 LBs. The rate of defects was 3.19 per 100 LBs (24 of 752 LBs) with first-trimester antiretroviral exposure, 3.54 per 100 LBs (41 of 1158 LBs) with exposure later in pregnancy, and 4.05 of 100 LBs (25 of 617 LBs) with no antiretroviral use. Only genital abnormalities, specifically hypospadias, were significantly increased among babies born to women with first-trimester exposure to antiretrovirals (7 of 382 male LBs) compared with the 2 other groups (2 of 892 male LBs; P = 0.007). On logistic regression, use of zidovudine in the first trimester was associated with hypospadias (adjusted odds ratio = 10.68, 95% confidence interval: 2.11 to 54.13; P = 0.004). In general, data were reassuring, although the frequency of exposure to newer agents was limited. The increased risk of hypospadias after first-trimester exposure must be explored, because this association has not been detected previously. JF - Journal of acquired immune deficiency syndromes (1999) AU - Watts, D Heather AU - Li, Daner AU - Handelsman, Ed AU - Tilson, Hugh AU - Paul, Mary AU - Foca, Marc AU - Vajaranant, Mark AU - Diaz, Clemente AU - Tuomala, Ruth AU - Thompson, Bruce AD - Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research on Mothers and Infants, National Institute of Child Health and Human Development/NIH, 6100 Executive Boulevard, Bethesda, MD 20892, USA. heather.watts@nih.hhs.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 299 EP - 305 VL - 44 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Infant KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Abnormalities, Drug-Induced KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Pregnancy Complications, Infectious -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70221585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Assessment+of+birth+defects+according+to+maternal+therapy+among+infants+in+the+Women+and+Infants+Transmission+Study.&rft.au=Watts%2C+D+Heather%3BLi%2C+Daner%3BHandelsman%2C+Ed%3BTilson%2C+Hugh%3BPaul%2C+Mary%3BFoca%2C+Marc%3BVajaranant%2C+Mark%3BDiaz%2C+Clemente%3BTuomala%2C+Ruth%3BThompson%2C+Bruce&rft.aulast=Watts&rft.aufirst=D&rft.date=2007-03-01&rft.volume=44&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Work, obesity, and occupational safety and health. AN - 69034671; 17267711 AB - There is increasing evidence that obesity and overweight may be related, in part, to adverse work conditions. In particular, the risk of obesity may increase in high-demand, low-control work environments, and for those who work long hours. In addition, obesity may modify the risk for vibration-induced injury and certain occupational musculoskeletal disorders. We hypothesized that obesity may also be a co-risk factor for the development of occupational asthma and cardiovascular disease that and it may modify the worker's response to occupational stress, immune response to chemical exposures, and risk of disease from occupational neurotoxins. We developed 5 conceptual models of the interrelationship of work, obesity, and occupational safety and health and highlighted the ethical, legal, and social issues related to fuller consideration of obesity's role in occupational health and safety. JF - American journal of public health AU - Schulte, Paul A AU - Wagner, Gregory R AU - Ostry, Aleck AU - Blanciforti, Laura A AU - Cutlip, Robert G AU - Krajnak, Kristine M AU - Luster, Michael AU - Munson, Albert E AU - O'Callaghan, James P AU - Parks, Christine G AU - Simeonova, Petia P AU - Miller, Diane B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. pas4@cdc.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 428 EP - 436 VL - 97 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Asthma -- etiology KW - Cardiovascular Diseases -- etiology KW - Humans KW - Occupational Diseases -- etiology KW - Workers' Compensation KW - Stress, Psychological -- etiology KW - Prejudice KW - Musculoskeletal Diseases -- etiology KW - Risk Factors KW - Adult KW - Privacy KW - Health Behavior KW - Middle Aged KW - Social Responsibility KW - Occupational Health KW - Obesity -- prevention & control KW - Occupational Exposure -- prevention & control KW - Work -- psychology KW - Work -- ethics KW - Occupational Exposure -- ethics KW - Occupational Exposure -- adverse effects KW - Obesity -- psychology KW - Work -- physiology KW - Obesity -- epidemiology KW - Occupational Exposure -- economics KW - Obesity -- complications KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69034671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Work%2C+obesity%2C+and+occupational+safety+and+health.&rft.au=Schulte%2C+Paul+A%3BWagner%2C+Gregory+R%3BOstry%2C+Aleck%3BBlanciforti%2C+Laura+A%3BCutlip%2C+Robert+G%3BKrajnak%2C+Kristine+M%3BLuster%2C+Michael%3BMunson%2C+Albert+E%3BO%27Callaghan%2C+James+P%3BParks%2C+Christine+G%3BSimeonova%2C+Petia+P%3BMiller%2C+Diane+B&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2007-03-01&rft.volume=97&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-12 N1 - Date created - 2007-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Public Health Policy. 2004;25(3-4):391-407 [15683074] Metabolism. 2005 May;54(5 Suppl 1):20-3 [15877308] Scand J Rheumatol. 2005;34(1):59-64 [15903028] J Occup Environ Med. 2005 Jun;47(6):607-22 [15951721] Am J Public Health. 2005 Aug;95(8):1389-95 [16006422] Ageing Res Rev. 2005 May;4(2):123-40 [15964248] J Health Soc Behav. 2005 Sep;46(3):244-59 [16259147] MMWR Recomm Rep. 2005 Oct 7;54(RR-10):1-12 [16261131] J Occup Environ Med. 2006 Jan;48(1):22-7 [16404206] Int J Epidemiol. 2006 Feb;35(1):83-92 [16339600] Scand J Work Environ Health. 2006 Feb;32(1):5-11 [16539166] BMC Public Health. 2006;6:53 [16512915] CMAJ. 2006 Apr 25;174(9):1293-9 [16636330] Med Lav. 2006 Mar-Apr;97(2):240-57 [17017356] J Appl Physiol (1985). 2004 Jun;96(6):2200-6 [14966019] Physiol Behav. 2004 Apr;81(2):243-8 [15159170] J Occup Environ Med. 2004 May;46(5):428-36 [15167389] Prev Med. 2004 Jun;38(6):848-56 [15193908] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):444-9 [15276425] Int J Obes Relat Metab Disord. 1993 Oct;17(10):597-604 [8242129] Arch Intern Med. 1999 Nov 22;159(21):2582-8 [10573048] Health Rep. 1999 Autumn;11(2):33-48(Eng); 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AN - 69030527; 17312200 AB - Some drugs used for sedation and anesthesia produce histopathologic central nervous system changes in juvenile animal models. These observations have raised concerns regarding the use of these drugs in pediatric patients. We summarized the findings in developing animals and describe the steps that the Food and Drug Administration (FDA) and others are taking to assess potential risks in pediatric patients. The FDA views this communication as opening a dialog with the anesthesia community to address this issue. We reviewed the available animal studies literature examining the potential neurotoxic effects of commonly used anesthetic drugs on the developing brain. The search strategy involved crossing the keywords neurotoxic and neuroapoptosis with the following general and specific terms: anesthetic, N-methyl-d-aspartate (NMDA), ketamine, midazolam, lorazepam, fentanyl, methadone, morphine, meperidine, isoflurane, nitrous oxide, sevoflurane, halothane, enflurane, desflurane, propofol, etomidate, barbiturate, methoxyflurane, and chloral hydrate. We summarized several studies sponsored by the FDA in rats and monkeys, initially examining the potential for ketamine, as a prototypical agent, to induce neurodegeneration in the developing brain. Numerous animal studies in rodents indicate that NMDA receptor antagonists, including ketamine, induce neurodegeneration in the developing brain. The effects of ketamine are dose dependent. The data suggest that limiting exposure limits the potential for neurodegeneration. There is also evidence that other general anesthetics, such as isoflurane, can induce neurodegeneration in rodent models, which may be exacerbated by concurrent administration of midazolam or nitrous oxide. There are very few studies that have examined the potential functional consequences of the neurodegeneration noted in the animal models. However, the studies that have been reported suggest subtle, but prolonged, behavioral changes in rodents. Although the doses and durations of ketamine exposure that resulted in neurodegeneration were slightly larger than those used in the clinical setting, those associated with isoflurane were not. There are insufficient human data to either support or refute the clinical applicability of these findings. Animal studies suggest that neurodegeneration, with possible cognitive sequelae, is a potential long-term risk of anesthetics in neonatal and young pediatric patients. The existing nonclinical data implicate not only NMDA-receptor antagonists, but also drugs that potentiate gamma-aminobutyric acid signal transduction, as potentially neurotoxic to the developing brain. The potential for the combination of drugs that have activity at both receptor systems or that can induce more or less neurotoxicity is not clear; however, recent nonclinical data suggest that some combinations may be more neurotoxic than the individual components. The lack of information to date precludes the ability to designate any one anesthetic agent or regimen as safer than any other. Ongoing studies in juvenile animals should provide additional information regarding the risks. The FDA anticipates working with the anesthesia community and pharmaceutical industry to develop strategies for further assessing the safety of anesthetics in neonates and young children, and for providing data to guide clinicians in making the most informed decisions possible when choosing anesthetic regimens for their pediatric patients. JF - Anesthesia and analgesia AU - Mellon, R Daniel AU - Simone, Arthur F AU - Rappaport, Bob A AD - Division of Anesthesia, Analgesia, and Rheumatology Products, Office of Drug Evaluation II, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland 20993, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 509 EP - 520 VL - 104 IS - 3 KW - Anesthetics KW - 0 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Animals KW - Apoptosis KW - Neurons -- metabolism KW - Humans KW - Safety KW - Infant, Newborn KW - Nerve Degeneration -- chemically induced KW - Child KW - Child, Preschool KW - Infant KW - United States Food and Drug Administration KW - gamma-Aminobutyric Acid -- metabolism KW - Signal Transduction KW - Anesthetics -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69030527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Use+of+anesthetic+agents+in+neonates+and+young+children.&rft.au=Mellon%2C+R+Daniel%3BSimone%2C+Arthur+F%3BRappaport%2C+Bob+A&rft.aulast=Mellon&rft.aufirst=R&rft.date=2007-03-01&rft.volume=104&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Anesth Analg. 2007 Sep;105(3):882; discussion 882-3 [17717262] Anesth Analg. 2007 Sep;105(3):881-2 [17717261] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. AN - 69014693; 16893525 AB - We and others reported time-dependent increases in cue-induced cocaine seeking after withdrawal, suggesting that craving incubates over time. Recently, we found that central amygdala extracellular signal-regulated kinases (ERK) and glutamate are involved in this incubation. Here, we further explored the role of central amygdala glutamate in the incubation of cocaine craving by determining the effect of systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) on cue-induced cocaine seeking during early and late withdrawal. Rats were trained to self-administer cocaine for 10 days (6 hours/day); infusions were paired with a tone-light cue. Cocaine seeking and craving after systemic or central amygdala injections of LY379268 were then assessed in extinction tests in the presence of the cocaine-associated cues during early (day 3) or late (day 21) withdrawal. Systemic (1.5 or 3 mg/kg) or central amygdala (.5 or 1.0 microg/side) injections of LY379268 attenuated enhanced extinction responding on day 21 but had no effect on lower extinction responding on day 3. Results confirm our previous findings on the role of central amygdala glutamate in the incubation of cocaine craving and together with previous reports suggest that mGluR(2/3) agonists should be considered in the treatment of drug relapse. JF - Biological psychiatry AU - Lu, Lin AU - Uejima, Jamie L AU - Gray, Sarah M AU - Bossert, Jennifer M AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. linlu@bjmu.edu.cn Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 591 EP - 598 VL - 61 IS - 5 SN - 0006-3223, 0006-3223 KW - Amino Acids KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - Dopamine Uptake Inhibitors KW - LY 379268 KW - Receptors, Metabotropic Glutamate KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Cocaine -- administration & dosage KW - Behavior, Animal KW - Drug Administration Routes KW - Rats KW - Self Administration KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Extinction, Psychological -- drug effects KW - Male KW - Amino Acids -- administration & dosage KW - Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage KW - Receptors, Metabotropic Glutamate -- administration & dosage KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Amygdala -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69014693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Systemic+and+central+amygdala+injections+of+the+mGluR%282%2F3%29+agonist+LY379268+attenuate+the+expression+of+incubation+of+cocaine+craving.&rft.au=Lu%2C+Lin%3BUejima%2C+Jamie+L%3BGray%2C+Sarah+M%3BBossert%2C+Jennifer+M%3BShaham%2C+Yavin&rft.aulast=Lu&rft.aufirst=Lin&rft.date=2007-03-01&rft.volume=61&rft.issue=5&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in rats. AN - 69010656; 16738542 AB - The hypothesis that prior cannabis exposure increases the likelihood of becoming addicted to other drugs can be evaluated by giving rats a history of tetrahydrocannabinol (THC) exposure, then allowing them to self-administer other drugs. In Experiment 1, THC pre-exposure did not alter the acquisition of cocaine self-administration or the amount of cocaine taken under a fixed-ratio 1 (FR1) schedule, with one response required for each injection. Under a progressive-ratio schedule, with the response requirement increasing exponentially with each injection, cocaine-seeking was significantly reduced in THC-exposed rats, suggesting that the regimen of THC exposure used in the present study caused cocaine to be devalued as a reinforcer. In contrast, in an earlier study that used the same regimen, a history of THC exposure did not alter the value of heroin as a reinforcer under the progressive-ratio schedule, but it increased heroin self-administration under the FR1 schedule. Experiment 2 examined how this regimen of THC pre-exposure alters the locomotor effects of cocaine and heroin. THC pre-exposure produced cross-tolerance to the motor-depressant effects of heroin; this may explain the shortened post-injection pauses exhibited by THC-exposed rats under FR1 heroin self-administration. When given cocaine, THC-exposed rats exhibited normal increases in locomotion, but they avoided the center of the open field, suggesting that this THC pre-exposure regimen enhances the anxiogenic effects of cocaine. This enhanced anxiogenic effect-which was verified in Experiment 3 using another model of anxiety, the light-dark test-may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Panlilio, Leigh V AU - Solinas, Marcello AU - Matthews, Stephanie A AU - Goldberg, Steven R AD - Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 646 EP - 657 VL - 32 IS - 3 SN - 0893-133X, 0893-133X KW - Analgesics, Non-Narcotic KW - 0 KW - Dopamine Uptake Inhibitors KW - Dronabinol KW - 7J8897W37S KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Conditioning, Operant -- drug effects KW - Reaction Time -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Self Administration KW - Reinforcement Schedule KW - Choice Behavior -- drug effects KW - Motor Activity -- drug effects KW - Behavior, Animal KW - Analgesics, Non-Narcotic -- pharmacology KW - Anxiety -- chemically induced KW - Dronabinol -- pharmacology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reinforcement (Psychology) KW - Anxiety -- physiopathology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69010656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Previous+exposure+to+THC+alters+the+reinforcing+efficacy+and+anxiety-related+effects+of+cocaine+in+rats.&rft.au=Panlilio%2C+Leigh+V%3BSolinas%2C+Marcello%3BMatthews%2C+Stephanie+A%3BGoldberg%2C+Steven+R&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New approaches to assessing the effects of mutagenic agents on the integrity of the human genome. AN - 68994705; 17174354 AB - Heritable genetic alterations, although individually rare, have a substantial collective health impact. Approximately 20% of these are new mutations of unknown cause. Assessment of the effect of exposures to DNA damaging agents, i.e. mutagenic chemicals and radiations, on the integrity of the human genome and on the occurrence of genetic disease remains a daunting challenge. Recent insights may explain why previous examination of human exposures to ionizing radiation, as in Hiroshima and Nagasaki, failed to reveal heritable genetic effects. New opportunities to assess the heritable genetic damaging effects of environmental mutagens are afforded by: (1) integration of knowledge on the molecular nature of genetic disorders and the molecular effects of mutagens; (2) the development of more practical assays for germline mutagenesis; (3) the likely use of population-based genetic screening in personalized medicine. JF - Mutation research AU - Elespuru, R K AU - Sankaranarayanan, K AD - Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, The Netherlands. Rosalie.Elespuru@fda.hhs.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 83 EP - 89 VL - 616 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Environmental Pollutants KW - 0 KW - Mutagens KW - Index Medicus KW - Registries KW - Environmental Pollutants -- toxicity KW - Humans KW - Germ Cells -- drug effects KW - Congenital Abnormalities -- epidemiology KW - Forecasting KW - Genetic Predisposition to Disease KW - Risk Assessment KW - Genetic Diseases, Inborn -- classification KW - Genomic Instability KW - Mutagens -- toxicity KW - Genetic Diseases, Inborn -- chemically induced KW - Germ-Line Mutation KW - Genome, Human -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68994705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=New+approaches+to+assessing+the+effects+of+mutagenic+agents+on+the+integrity+of+the+human+genome.&rft.au=Elespuru%2C+R+K%3BSankaranarayanan%2C+K&rft.aulast=Elespuru&rft.aufirst=R&rft.date=2007-03-01&rft.volume=616&rft.issue=1-2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional profiling for understanding the basis of mitochondrial involvement in disease and toxicity using the mitochondria-specific MitoChip. AN - 68993264; 17174985 AB - It is well documented that mitochondrial dysfunction significantly contributes to a number of degenerative diseases, metabolic disorders, and drug- and chemical-induced toxicities. Thus far, information gained by several molecular and biochemical techniques used to delineate the mechanism of impaired mitochondrial activity underlying different diseases and various toxicities is still limited due to their low throughput potential. Here, we describe the development of mitochondria-specific mouse oligonucleotide microarray and its potential to define mechanisms of disease progression and drug toxicities associated with mitochondrial dysfunction at both nuclear and mitochondrial genome level. JF - Mutation research AU - Desai, Varsha G AU - Fuscoe, James C AD - Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-130, Jefferson, AR 72079, USA. varsha.desai@fda.hhs.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 210 EP - 212 VL - 616 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA, Mitochondrial KW - 0 KW - Reverse Transcriptase Inhibitors KW - Lamivudine KW - 2T8Q726O95 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Animals KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Zidovudine -- pharmacology KW - Disease Progression KW - Lamivudine -- pharmacology KW - Mice KW - Female KW - Mitochondria -- drug effects KW - DNA, Mitochondrial -- metabolism KW - Oligonucleotide Array Sequence Analysis -- methods KW - Mitochondria -- metabolism KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68993264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Transcriptional+profiling+for+understanding+the+basis+of+mitochondrial+involvement+in+disease+and+toxicity+using+the+mitochondria-specific+MitoChip.&rft.au=Desai%2C+Varsha+G%3BFuscoe%2C+James+C&rft.aulast=Desai&rft.aufirst=Varsha&rft.date=2007-03-01&rft.volume=616&rft.issue=1-2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a standardized micro-vacuum sampling method for collection of surface dust. AN - 68928864; 17237027 AB - A standardized procedure for collecting dust samples from surfaces using a micro-vacuum sampling technique was evaluated. Experiments were carried out to investigate the collection efficiency of the vacuum sampling method described in ASTM Standard D7144, "Standard Practice for Collection of Surface Dust by Micro-Vacuum Sampling for Subsequent Metals Determination." Weighed masses ( approximately 5, approximately 10 and approximately 25 mg) of three NIST Standard Reference Materials (SRMs) were spiked onto surfaces of various substrates. The SRMs used were: (1) Powdered Lead-Based Paint; (2) Urban Particulate Matter; and (3) Trace Elements in Indoor Dust. Twelve different substrate materials were chosen to be representative of surfaces commonly encountered in occupational and/or indoor settings: (1) wood, (2) tile, (3) linoleum, (4) vinyl, (5) industrial carpet, (6) plush carpet, (7,8) concrete block (painted and unpainted), (9) car seat material, (10) denim, (11) steel, and (12) glass. Samples of SRMs originally spiked onto these surfaces were collected using the standardized micro-vacuum sampling procedure. Gravimetric analysis of material collected within preweighed Accucapinserts (housed within the samplers) was used to measure SRM recoveries. Recoveries ranged from 21.6% (+/- 10.4%, 95% confidence limit [CL]) for SRM 1579 from industrial carpet to 59.2% (+/- 11.0%, 95% CL) for SRM 1579 from glass. For most SRM/substrate combinations, recoveries ranged from approximately 25% to approximately 50%; variabilities differed appreciably. In general, SRM recoveries were higher from smooth and hard surfaces and lower from rough and porous surfaces. Material captured within collection nozzles attached to the sampler inlets was also weighed. A significant fraction of SRM originally spiked onto substrate surfaces was captured within collection nozzles. Percentages of SRMs captured within collection nozzles ranged from approximately 13% (+/- 4 - +/- 5%, 95% CLs) for SRMs 1579 and 2583 from industrial carpet to approximately 45% (+/- 7 - +/- 26%, 95% CLs) for SRM 1648 from glass, tile and steel. For some substrates, loose material from the substrate itself (i.e., substrate particles and fibers) was sometimes collected along with the SRM, both within Accucaps as well as collection nozzles. Co-collection of substrate material can bias results and contribute to sampling variability. The results of this work have provided performance data on the standardized micro-vacuum sampling procedure. JF - Journal of occupational and environmental hygiene AU - Ashley, Kevin AU - Applegate, Gregory T AU - Wise, Tamara J AU - Fernback, Joseph E AU - Goldcamp, Michael J AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. KAshley@cdc.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 215 EP - 223 VL - 4 IS - 3 SN - 1545-9624, 1545-9624 KW - Dust KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Occupational Health KW - Equipment Design KW - Humans KW - Reference Standards KW - Vacuum KW - Microscopy, Electron KW - Dust -- analysis KW - Chemistry Techniques, Analytical -- methods KW - Specimen Handling -- methods KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Evaluation+of+a+standardized+micro-vacuum+sampling+method+for+collection+of+surface+dust.&rft.au=Ashley%2C+Kevin%3BApplegate%2C+Gregory+T%3BWise%2C+Tamara+J%3BFernback%2C+Joseph+E%3BGoldcamp%2C+Michael+J&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2007-03-01&rft.volume=4&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of C-glycoside flavonoids as potential mutagenic compounds in kava. AN - 68489806; 17995826 AB - Kava (Piper methysticum) extract products have been implicated in a number of severe hepatotoxicity cases. However, systematic toxicological studies regarding kava consumption have not been reported. In this study, 6 major kavalactones and different solvent fractions of kava roots, leaves, and stem peelings were evaluated for their mutagenic potential. None of the kavalactones was found to be positive in the experimental concentration ranges tested by the umu test (a sensitive test for point mutations). However, among the different solvent fractions, the n-butanol fraction of kava leaves was positive. Further investigations using bioassay-directed isolation and analysis indicated that 2 C-glycoside flavonoid compounds accounted for the positive mutagenic results. Two isolated compounds were identified as 2''-O-rhamnosylvitexin and schaftoside by NMR and MS techniques. JF - Journal of food science AU - Jhoo, J-W AU - Ang, C Y W AU - Heinze, T M AU - Deck, J AU - Schnackenberg, L K AU - Beger, R D AU - Dragull, K AU - Tang, C-S AD - Natl. Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. jjhoo@kangwon.ac.kr Y1 - 2007/03// PY - 2007 DA - March 2007 SP - C120 EP - C125 VL - 72 IS - 2 KW - C-glycoside KW - 0 KW - Flavonoids KW - Monosaccharides KW - Plant Extracts KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Chemical and Drug Induced Liver Injury KW - Point Mutation KW - Biological Assay KW - Salmonella typhimurium -- drug effects KW - Plant Stems -- chemistry KW - Plant Leaves -- chemistry KW - Plant Roots -- chemistry KW - Flavonoids -- isolation & purification KW - Mutagenicity Tests KW - Monosaccharides -- isolation & purification KW - Plant Extracts -- toxicity KW - Kava -- chemistry KW - Monosaccharides -- toxicity KW - Flavonoids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68489806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+science&rft.atitle=Identification+of+C-glycoside+flavonoids+as+potential+mutagenic+compounds+in+kava.&rft.au=Jhoo%2C+J-W%3BAng%2C+C+Y+W%3BHeinze%2C+T+M%3BDeck%2C+J%3BSchnackenberg%2C+L+K%3BBeger%2C+R+D%3BDragull%2C+K%3BTang%2C+C-S&rft.aulast=Jhoo&rft.aufirst=J-W&rft.date=2007-03-01&rft.volume=72&rft.issue=2&rft.spage=C120&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+science&rft.issn=1750-3841&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use and tobacco abstinence among adolescents in cessation treatment: preliminary findings. AN - 68412345; 16814935 AB - Although adult alcohol use is negatively associated with tobacco cessation, this relationship has not been reported for adolescents. We assessed the relationship between alcohol use and point prevalence abstinence from smoking in a sample of tobacco-dependent adolescents undergoing cessation treatment. Alcohol use both at baseline and) during tobacco cessation treatment was examined as predicting smoking abstinence in 101 adolescents (age=15.1years, S.D.=1.31years; age at first cigarette=11.3years, S.D.=1.93years; age at first drink=12.01years, S.D.=2.87years) attending a total of 642 treatment visits. Mixed regression analysis showed that participants who reported alcohol use during tobacco cessation treatment were significantly less likely to abstain from tobacco smoking (OR=0.42, 95% CI=0.23-0.78, t=-2.78, df=540, p=0.0057). However, pre-enrollment alcohol use was not significantly associated with either short- or long-term tobacco abstinence. If confirmed in a larger group of adolescents, our findings suggest that youths attempting to quit smoking should abstain from alcohol. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 617 EP - 621 VL - 32 IS - 3 SN - 0306-4603, 0306-4603 KW - Chewing Gum KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Regression Analysis KW - Nicotine -- therapeutic use KW - Administration, Cutaneous KW - Tobacco Use Disorder -- drug therapy KW - Humans KW - Tobacco Use Disorder -- psychology KW - Adolescent KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Alcohol Drinking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68412345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Alcohol+use+and+tobacco+abstinence+among+adolescents+in+cessation+treatment%3A+preliminary+findings.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photodecomposition of vitamin A and photobiological implications for the skin. AN - 68230892; 17576350 AB - Vitamin A (retinol), an essential human nutrient, plays an important role in cellular differentiation, regulation of epidermal cell growth and normal cell maintenance. In addition to these physiological roles, vitamin A has a rich photochemistry. Photoisomerization of vitamin A, involved in signal transduction for vision, has been extensively investigated. The biological effects of light-induced degradation of vitamin A and formation of reactive species are less understood and may be important for light-exposed tissues, such as the skin. Photochemical studies have demonstrated that excitation of retinol or its esters with UV light generates a number of reactive species including singlet oxygen and superoxide radical anion. These reactive oxygen species have been shown to damage a number of cellular targets, including lipids and DNA. Consistent with the potential for damaging DNA, retinyl palmitate has been shown to be photomutagenic in an in vitro test system. The results of mechanistic studies were consistent with mutagenesis through oxidative damage. Vitamin A in the skin resides in a complex environment that in many ways is very different from the chemical environment in solution and in in vitro test systems. Relevant clinical studies or studies in animal models are therefore needed to establish whether the pro-oxidant activity of photoexcited vitamin A is observed in vivo, and to assess the related risks. JF - Photochemistry and photobiology AU - Fu, Peter P AU - Xia, Qingsu AU - Yin, Jun Jie AU - Cherng, Shu-Hui AU - Yan, Jian AU - Mei, Nan AU - Chen, Tao AU - Boudreau, Mary D AU - Howard, Paul C AU - Wamer, Wayne G AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. peter.fu@fda.hhs.gov PY - 2007 SP - 409 EP - 424 VL - 83 IS - 2 SN - 0031-8655, 0031-8655 KW - Retinoids KW - 0 KW - Vitamin A KW - 11103-57-4 KW - Index Medicus KW - Photochemistry KW - Retinoids -- metabolism KW - Retinoids -- chemistry KW - Humans KW - In Vitro Techniques KW - Ultraviolet Rays -- adverse effects KW - Spectrophotometry, Ultraviolet KW - Photobiology KW - Retinoids -- radiation effects KW - Models, Biological KW - Skin -- radiation effects KW - Vitamin A -- chemistry KW - Skin -- metabolism KW - Vitamin A -- metabolism KW - Vitamin A -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68230892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Photodecomposition+of+vitamin+A+and+photobiological+implications+for+the+skin.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BYin%2C+Jun+Jie%3BCherng%2C+Shu-Hui%3BYan%2C+Jian%3BMei%2C+Nan%3BChen%2C+Tao%3BBoudreau%2C+Mary+D%3BHoward%2C+Paul+C%3BWamer%2C+Wayne+G&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2007-03-01&rft.volume=83&rft.issue=2&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Product Quality Research Institute evaluation of cascade impactor profiles of pharmaceutical aerosols, part 1: Background for a statistical method AN - 21127413; 11176398 AB - The purpose of this article is 2-fold: (1) to document in the public domain the considerations that led to the development of a regulatory statistical test for comparison of aerodynamic particle size distribution (APSD) of aerosolized drug formulations, which was proposed in a US Food and Drug Administration (FDA) draft guidance for industry; and (2) to explain the background and process for evaluation of that test through a working group involving scientists from the FDA, industry, academia, and the US Pharmacopeia, under the umbrella of the Product Quality Research Institute (PQRI). The article and the referenced additional statistical information posted on the PQRI Web site explain the reasoning and methods used in the development of the APSD test, which is one of the key tests required for demonstrating in vitro equivalence of orally inhaled and nasal aerosol drug products. The article also describes the process by which stakeholders with different perspectives have worked collaboratively to evaluate properties of the test by drawing on statistical models, historical and practical information, and scientific reasoning. Overall, this article provides background information to accompany the companion article's discussion of the study's methods and results. JF - AAPS PharmSciTech AU - Adams, Wallace P AU - Christopher, David AU - Lee, Douglas S AU - Morgan, Beth AU - Pan, Ziqing AU - Singh, Gur Jai Pal AU - Tsong, Yi AU - Lyapustina, Svetlana AD - Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, svetlana.lyapustina@dbr.com Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - E32 EP - E37 PB - Springer New York LLC VL - 8 IS - 1 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Particle size KW - Aerosols KW - Statistics KW - Mathematical models KW - Statistical analysis KW - Pharmaceuticals KW - Drug development KW - Food quality KW - Models KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21127413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Product+Quality+Research+Institute+evaluation+of+cascade+impactor+profiles+of+pharmaceutical+aerosols%2C+part+1%3A+Background+for+a+statistical+method&rft.au=Adams%2C+Wallace+P%3BChristopher%2C+David%3BLee%2C+Douglas+S%3BMorgan%2C+Beth%3BPan%2C+Ziqing%3BSingh%2C+Gur+Jai+Pal%3BTsong%2C+Yi%3BLyapustina%2C+Svetlana&rft.aulast=Adams&rft.aufirst=Wallace&rft.date=2007-03-01&rft.volume=8&rft.issue=1&rft.spage=E32&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fpt0801004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Particle size; Aerosols; Mathematical models; Statistics; Statistical analysis; Pharmaceuticals; Drug development; Food quality; Models DO - http://dx.doi.org/10.1208/pt0801004 ER - TY - JOUR T1 - Analytical Performance Criteria AN - 20965486; 8501941 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Harper, Martin AU - Lee, Eun Gyung AU - Harvey, Bruce AU - Beard, Michael AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - D42 EP - D45 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 4 IS - 5 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20965486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Analytical+Performance+Criteria&rft.au=Ashley%2C+Kevin%3BHarper%2C+Martin%3BLee%2C+Eun+Gyung%3BHarvey%2C+Bruce%3BBeard%2C+Michael&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2007-03-01&rft.volume=4&rft.issue=5&rft.spage=D42&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701246414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15459620701246414 ER - TY - JOUR T1 - Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Acrylamide and Its Metabolites in Mice, Rats, and Humans AN - 20799550; 7599753 AB - A physiologically based pharmacokinetic model was developed for acrylamide (AA) and three of its metabolites: glycidamide (GA) and the glutathione conjugates of acrylamide (AA-GS) and glycidamide (GA-GS). Liver GA-DNA adducts and hemoglobin (Hb) adducts with AA and GA were included as pharmacodynamic components of the model. Serum AA and GA concentrations combined with urinary elimination levels for all four components from male and female mice and rats were simulated from iv and oral administration of 0.1 mg/kg AA or 0.12 mg/kg GA. Adduct formation and decay rates were determined from a 6 week exposure to approximately 1 mg/kg AA in the drinking water and subsequent 6 week nonexposure period. Human urinary excretion data and Hb adduct data were utilized to extrapolate to a human model. The steady-state human liver GA-DNA adduct level from exposure to background levels of AA in the diet was predicted to be between 0.06 and 0.26 adducts per 10 super(8) nucleotides. JF - Chemical Research in Toxicology AU - Young, J F AU - Luecke, R H AU - Doerge AD - Divisions of Biometry & Risk Assessment and Biochemical Toxicology, National Center for Toxicological Research (NCTR)/Food and Drug Administration, Jefferson, Arkansas 72079, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 388 EP - 399 VL - 20 IS - 3 SN - 0893-228X, 0893-228X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Diets KW - Data processing KW - Glutathione KW - Adducts KW - Oral administration KW - Metabolites KW - Nucleotides KW - Pharmacokinetics KW - Models KW - Hemoglobin KW - Acrylamide KW - Background levels KW - Liver KW - Excretion KW - Drinking water KW - Pharmacodynamics KW - N 14840:Antisense, Nucleotide Analogs KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Physiologically+Based+Pharmacokinetic%2FPharmacodynamic+Model+for+Acrylamide+and+Its+Metabolites+in+Mice%2C+Rats%2C+and+Humans&rft.au=Young%2C+J+F%3BLuecke%2C+R+H%3BDoerge&rft.aulast=Young&rft.aufirst=J&rft.date=2007-03-01&rft.volume=20&rft.issue=3&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx600287w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Data processing; Glutathione; Adducts; Oral administration; Metabolites; Pharmacokinetics; Nucleotides; Models; Hemoglobin; Acrylamide; Background levels; Liver; Excretion; Drinking water; Pharmacodynamics DO - http://dx.doi.org/10.1021/tx600287w ER - TY - JOUR T1 - Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study AN - 20727640; 7314986 AB - Analysis of gene expression data suggests that breast cancers are divisible into molecular subtypes which have distinct clinical features. This study evaluates whether pathologic features and etiologic associations differ among molecular subtypes. We evaluated 804 women with invasive breast cancers and 2,502 controls participating in a Polish Breast Cancer Study. Immunohistochemical stains for estrogen receptor alpha , progesterone receptor, human epidermal growth factor receptors (HER2 and HER1), and cytokeratin 5 were used to classify cases into five molecular subtypes: luminal A, luminal B, HER2-expresing, basal-like, and unclassified. Relative risks were estimated using adjusted odds ratios and 95% confidence intervals. We observed that compared with the predominant luminal A tumors (69%), other subtypes were associated with unfavorable clinical features at diagnosis, especially HER2-expressing (8%) and basal-like (12%) tumors. Increasing body mass index significantly reduced the risk of luminal A tumors among premenopausal women (odds ratios, 0.71; 95% confidence intervals, 0.57-0.88 per five-unit increase), whereas it did not reduce risk for basal-like tumors (1.18; 0.86-1.64; P sub(heterogeneity) = 0.003). On the other hand, reduced risk associated with increasing age at menarche was stronger for basal-like (0.78; 0.68-0.89 per 2-year increase) than luminal A tumors (0.90; 0.95-1.08; P sub(heterogeneity) = 0.0009). Although family history increased risk for all subtypes (except for unclassified tumors), the magnitude of the relative risk was highest for basal-like tumors. Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):439-43) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Yang, Xiaohong R AU - Sherman, Mark E AU - Rimm, David L AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Peplonska, Beata AU - Hewitt, Stephen M AU - Anderson, William F AU - Szeszenia-Dabrowska, Neonila AU - Bardin-Mikolajczak, Alicja AU - Zatonski, Witold AU - Cartun, Richard AU - Mandich, Daniza AU - Rymkiewicz, Grzegorz AU - Ligaj, Marcin AU - Lukaszek, Stanislaw AU - Kordek, Radzisaw AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, Tissue Array Research Program, Laboratory of Pathology, Center For Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 439 EP - 443 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - risk reduction KW - Genetics KW - Age KW - body mass KW - prevention KW - Breast cancer KW - tumors KW - growth factors KW - Cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Differences+in+Risk+Factors+for+Breast+Cancer+Molecular+Subtypes+in+a+Population-Based+Study&rft.au=Yang%2C+Xiaohong+R%3BSherman%2C+Mark+E%3BRimm%2C+David+L%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPeplonska%2C+Beata%3BHewitt%2C+Stephen+M%3BAnderson%2C+William+F%3BSzeszenia-Dabrowska%2C+Neonila%3BBardin-Mikolajczak%2C+Alicja%3BZatonski%2C+Witold%3BCartun%2C+Richard%3BMandich%2C+Daniza%3BRymkiewicz%2C+Grzegorz%3BLigaj%2C+Marcin%3BLukaszek%2C+Stanislaw%3BKordek%2C+Radzisaw%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Genetics; risk reduction; Age; body mass; prevention; Breast cancer; tumors; growth factors; Cancer; estrogens ER - TY - JOUR T1 - Physical Collection Efficiency of Filter Materials for Bacteria and Viruses AN - 20697889; 7314172 AB - The purpose of this study was to determine the physical collection efficiency of commercially available filters for collecting airborne bacteria, viruses, and other particles in the 10-900 nm (nanometer) size range. Laboratory experiments with various polytetrafluoroethylene (PTFE), polycarbonate (PC) and gelatin filters in conjunction with Button super(TM) Inhalable samplers and three-piece cassettes were undertaken. Both biological and non-biological test aerosols were used: Bacillus atrophaeus, MS2, polystyrene latex (PSL), and sodium chloride (NaCl). The B.atrophaeus endospores had an aerodynamic diameter of 900 nm, whereas MS2 virion particles ranged from 10 to 80 nm. Monodisperse 350 nm PSL particles were used as this size was believed to have the lowest filtration efficiency. NaCl solution (1% weight by volume) was used to create a polydisperse aerosol in the 10-600 nm range. The physical collection efficiency was determined by measuring particle concentrations size-selectively upstream and downstream of the filters. The PTFE and gelatin filters showed excellent collection efficiency (>93%) for all of the test particles. The PC filters showed lower collection efficiency for small particles especially <100 nm. Among the tested filters, the lowest collection efficiencies, 49 and 22%, were observed for 1 and 3- mu m pore size PC filters at the particle sizes of 47 and 63 nm, respectively. The results indicate that the effect of filter material is more significant for the size range of single virions than for bacteria. The effect of filter loading was examined by exposing filters to mixtures of PSL particles, which aimed at mimicking typical indoor dust levels and size distributions. A 4-h loading did not cause significant change in the physical collection efficiency of the tested filters. JF - Annals of Occupational Hygiene AU - Burton, Nancy Clark AU - Grinshpun, Sergey A AU - Reponen, Tiina AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health 4676 Columbia Parkway, MS R-11, Cincinnati, OH, 45226, USA. Department of Environmental Health, University of Cincinnati PO Box 670056, Cincinnati, OH 45267, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 143 EP - 151 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 51 IS - 2 SN - 0003-4878, 0003-4878 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Pollution Abstracts; Health & Safety Science Abstracts KW - Virions KW - Viruses KW - Gelatin KW - Particulates KW - polytetrafluoroethylene KW - Dust KW - Aerodynamics KW - polystyrene KW - Bacillus KW - Occupational exposure KW - polycarbonate KW - Sodium chloride KW - Particle size KW - Mimicry KW - Aerosols KW - Laboratory testing KW - Latex KW - Samplers KW - Filters KW - Pores KW - Filtration KW - latex KW - Airborne bacteria KW - Size distribution KW - V 22300:Methods KW - A 01450:Environmental Pollution & Waste Treatment KW - H 1000:Occupational Safety and Health KW - J 02490:Miscellaneous KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20697889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Physical+Collection+Efficiency+of+Filter+Materials+for+Bacteria+and+Viruses&rft.au=Burton%2C+Nancy+Clark%3BGrinshpun%2C+Sergey+A%3BReponen%2C+Tiina&rft.aulast=Burton&rft.aufirst=Nancy&rft.date=2007-03-01&rft.volume=51&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Mimicry; Aerosols; Gelatin; Latex; polytetrafluoroethylene; Samplers; Dust; Filters; Filtration; Pores; polystyrene; Airborne bacteria; Size distribution; Sodium chloride; polycarbonate; Particle size; Laboratory testing; Aerodynamics; Viruses; latex; Particulates; Occupational exposure; Bacillus ER - TY - JOUR T1 - Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes AN - 20684470; 7311562 AB - Background: Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT). are emerging as technologically important in different industries. Objective: The unique physical characteristics and the pulmonary toxidty of SWCNTs raised concerns that respiratory exposure to these materials may be associated with cardiovascular adverse effects. Methods: In these studies we evaluated aortic mitochondrial alterations by oxidative stress assays, including quantitative polymerase chain reaction of mitochondrial (mt) DNA and plaque formation by morphometric analysis in mice exposed to SWCNTs. Results: A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice. Furthermore, we found that C57BL/6 mice, exposed to SWCNT (10 and 40 mu g/mouse), developed aortic mtDNA damage at 7, 28, and 60 days after exposure. mtDNA damage was accompanied by changes in aortic mitochondrial glutathione and protein carbonyl levels. Because these modifications have been related to cardiovascular diseases, we evaluated whether repeated exposure to SWCNTs (20 mu g/mouse once every other week for 8 weeks) stimulates the progression of atherosclerosis in ApoE super(-/-) transgenic mice. Although SWCNT exposure did not modify the lipid profiles of these mice, it resulted in accelerated plaque formation in ApoE super(-/-) mice fed an atherogenic diet. Plaque areas in the aortas, measured by the en face method, and in the brachiocephalic arteries, measured histopathologically, were significantly increased in the SWCNT-treated mice. This response was accompanied by increased mtDNA damage but not inflammation. Conclusions: Taken together, the findings are of sufficient significance to warrant further studies to evaluate the systemic effects of SWCNT under workplace or environmental exposure paradigms. JF - Environmental Health Perspectives AU - Li, Z AU - Hulderman, T AU - Salmen, R AU - Chapman, R AU - Leonard, S S AU - Young, S-H AU - Shvedova, A AU - Luster, MI AU - Simeonova, P P AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 USA, PSimeonova@cdc.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 377 EP - 382 VL - 115 IS - 3 SN - 0091-6765, 0091-6765 KW - Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Toxicology Abstracts KW - Atherogenic diet KW - Glutathione KW - Lipids KW - Arteries KW - Mitochondria KW - Arteriosclerosis KW - Nanotechnology KW - Public health KW - Carbon KW - Oxidative stress KW - Polymerase chain reaction KW - Plaques KW - carbonyl compounds KW - Heart KW - Physical characteristics KW - Aorta KW - Stress KW - Mice KW - Heme oxygenase (decyclizing) KW - Transgenic mice KW - Inflammation KW - Mitochondrial DNA KW - Lung KW - DNA KW - Proteins KW - nanotubes KW - Cardiovascular diseases KW - carbonyls KW - Side effects KW - X 24490:Other KW - H 12000:Epidemiology and Public Health KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20684470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cardiovascular+Effects+of+Pulmonary+Exposure+to+Single-Wall+Carbon+Nanotubes&rft.au=Li%2C+Z%3BHulderman%2C+T%3BSalmen%2C+R%3BChapman%2C+R%3BLeonard%2C+S+S%3BYoung%2C+S-H%3BShvedova%2C+A%3BLuster%2C+MI%3BSimeonova%2C+P+P&rft.aulast=Li&rft.aufirst=Z&rft.date=2007-03-01&rft.volume=115&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9688 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Physical characteristics; Atherogenic diet; Glutathione; Aorta; Arteries; Lipids; Mitochondria; Heme oxygenase (decyclizing); Arteriosclerosis; Transgenic mice; Inflammation; Mitochondrial DNA; Carbon; Lung; Oxidative stress; Polymerase chain reaction; nanotubes; Plaques; Cardiovascular diseases; carbonyls; Side effects; DNA; Stress; Proteins; Mice; carbonyl compounds; Public health; Nanotechnology DO - http://dx.doi.org/10.1289/ehp.9688 ER - TY - JOUR T1 - Human stem cells, chromatin, and tissue engineering: Boosting relevancy in developmental toxicity testing AN - 20639106; 7596939 AB - Risk assessment derives its confidence from toxicology research that is based on relevancy to human health. This article focuses on two highly topical areas of current scientific research, stem cells and chromatin biology, which present new avenues for preclinical and clinical applications, and the frontier role of tissue engineering and regeneration. Appreciating the utility and necessity of chromatin and human somatic stem cells as research tools and looking toward tissue engineering may close the uncertainty gaps between animal and human cross-species toxicology evaluations. The focus will be on developmental toxicology applications, but appropriate extrapolation to any other areas of toxicology can be made. We further provide background on basic biology of these three areas and examples of how early life exposure to known and potential environmental toxicants induce malformations, childhood and adult-onset diseases, through aberrant chromatin modification of critical gene expressions (acute lymphocyte leukemia, heavy-metal nickel and cadmium-associated defects, and reproductive tract malformations and carcinomas induced by the synthetic estrogen, diethylstilbestrol). Birth Defects Research (Part C) 81:20-40, 2007. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Cho, Elizabeth AU - Li, Wan-Ju AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, chofertikh@hotmail.com Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 20 EP - 40 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 81 IS - 1 SN - 1542-975X, 1542-975X KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Estrogens KW - Toxicants KW - Chromatin KW - Nickel KW - Lymphocytes KW - Tissue engineering KW - Children KW - Carcinoma KW - Gene expression KW - Leukemia KW - Stem cells KW - Congenital defects KW - Embryos KW - Diethylstilbestrol KW - Toxicity testing KW - W 30920:Tissue Engineering KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Human+stem+cells%2C+chromatin%2C+and+tissue+engineering%3A+Boosting+relevancy+in+developmental+toxicity+testing&rft.au=Cho%2C+Elizabeth%3BLi%2C+Wan-Ju&rft.aulast=Cho&rft.aufirst=Elizabeth&rft.date=2007-03-01&rft.volume=81&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Estrogens; Chromatin; Toxicants; Nickel; Lymphocytes; Children; Tissue engineering; Carcinoma; Gene expression; Leukemia; Stem cells; Congenital defects; Embryos; Diethylstilbestrol; Toxicity testing DO - http://dx.doi.org/10.1002/bdrc.20087 ER - TY - JOUR T1 - PCR-Based Detection of Angiostrongylus cantonensis in Tissue and Mucus Secretions from Molluscan Hosts AN - 20609852; 7285410 AB - Angiostrongylus cantonensis is a common cause of human eosinophilic meningitis. Recent outbreaks of this infection have shown that there is a need to determine the distribution of this nematode in the environment in order to control transmission. A. cantonensis is generally identified morphologically in the molluscan intermediate host by microscopic examination, which can be labor-intensive. The aim of this study was to develop a PCR-based method to detect A. cantonensis directly from molluscan tissue. A total of 34 Parmarion cf. martensi (Simroth) semislugs, 25 of which were naturally infected with A. cantonensis, were used to develop this assay. Tissue pieces (approximately 25 mg) were digested with pepsin-HCl to recover third-stage larvae for morphological identification or were used for DNA extraction. PCR primers were designed to amplify 1,134 bp from the Angiostrongylus 18S rRNA gene, and the amplicons produced were sequenced for identification at the species level. Both microscopy and the PCR-DNA sequencing analysis indicated that the same 25 semislugs were positive for A. cantonensis, showing that the two methods were equally sensitive and specific for this application. However, morphological detection requires access to living mollusks, whereas molecular analysis can also be performed with frozen tissue. The PCR-DNA sequencing method was further evaluated using tissue from Veronicella cubensis (Pfeiffer) slugs and mucus secretions from infected P. martensi. To our knowledge, this is the first use of a PCR-based method to confirm the presence of A. cantonensis in mollusks collected in the environment. JF - Applied and Environmental Microbiology AU - Qvarnstrom, Yvonne AU - Sullivan, James J AU - Bishop, Henry S AU - Hollingsworth, Robert AU - da Silva, Alexandre J AD - Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia. Atlanta Research and Education Foundation in Conjunction with the Atlanta VA Medical Center, Decatur, Georgia. U.S. Pacific Basin Agricultural Research Center, U.S. Department of Agriculture, Hilo, Hawaii Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 1415 EP - 1419 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 73 IS - 5 SN - 0099-2240, 0099-2240 KW - ASFA Marine Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources KW - rRNA 18S KW - Nucleotide sequence KW - Secretion KW - Secretions KW - Angiostrongylus KW - Mucus KW - Hosts KW - Infection KW - Larval development KW - Meningitis KW - Disease transmission KW - Population genetics KW - Microbiology KW - DNA KW - Polymerase chain reaction KW - Angiostrongylus cantonensis KW - Mollusca KW - Nematoda KW - Q1 08203:Taxonomy and morphology KW - Q4 27700:Molecular Techniques KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20609852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=PCR-Based+Detection+of+Angiostrongylus+cantonensis+in+Tissue+and+Mucus+Secretions+from+Molluscan+Hosts&rft.au=Qvarnstrom%2C+Yvonne%3BSullivan%2C+James+J%3BBishop%2C+Henry+S%3BHollingsworth%2C+Robert%3Bda+Silva%2C+Alexandre+J&rft.aulast=Qvarnstrom&rft.aufirst=Yvonne&rft.date=2007-03-01&rft.volume=73&rft.issue=5&rft.spage=1415&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Population genetics; Secretion; Nucleotide sequence; Microbiology; DNA; Polymerase chain reaction; Mucus; Hosts; Larval development; rRNA 18S; Secretions; Infection; Disease transmission; Meningitis; Angiostrongylus; Mollusca; Angiostrongylus cantonensis; Nematoda ER - TY - JOUR T1 - Bactericidal activity of cefepime and ceftriaxone tested against Streptococcus pneumoniae AN - 20301239; 7583746 AB - The bactericidal activities of cefepime and ceftriaxone were assessed by testing a contemporary collection of 50 Streptococcus pneumoniae strains. Minimum inhibitory and bactericidal concentrations (MIC and MBC, respectively) of cefepime and ceftriaxone were determined, and time-kill studies were performed on 14 selected strains (10 penicillin-resistant, 2-intermediate, and 2-susceptible). Cefepime and ceftriaxone showed essentially identical potency (MIC50, 1 is a subset of g/mL and MIC90, 2 is a subset of g/mL, for both compounds) and MBC values (MBC50, 1 is a subset of g/mL for both). MBC/MIC ratios were =32 (tolerance) to the 2 cephalosporins. Time-kill curves corroborated the MBC/MIC studies. Cefepime and ceftriaxone bactericidal activity (>=3 log10 CFU/mL reduction in inoculum) was demonstrable after 24 h of exposure to 8X MIC for 13 (92.9%) of 14 strains, whereas 1 strain showed approximately 2 log10 CFU/mL reduction. In conclusion, our results indicate that cefepime and ceftriaxone exhibit comparable potency and bactericidal activities when tested against contemporary pneumococcal strains with varying penicillin susceptibility patterns. Both parenteral cephems offer alternative therapeutic choices for the treatment of invasive pneumococcal infections. JF - Diagnostic Microbiology and Infectious Disease AU - Pottumarthy, Sudha AU - Sader, Helio S AU - Jones, Ronald N AD - Houston Department of Health and Human Services, Houston, TX 77054, USA, helio-sader@jmilabs.com Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 345 EP - 349 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 57 IS - 3 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts B: Bacteriology KW - Cefepime KW - Ceftriaxone KW - Streptococcus pneumoniae KW - Bactericidal activity KW - Time kill curve KW - Tolerance KW - Bacteria KW - Cephalosporins KW - Infection KW - Minimum inhibitory concentration KW - cephems KW - Penicillin KW - Colony-forming cells KW - Inoculum KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Bactericidal+activity+of+cefepime+and+ceftriaxone+tested+against+Streptococcus+pneumoniae&rft.au=Pottumarthy%2C+Sudha%3BSader%2C+Helio+S%3BJones%2C+Ronald+N&rft.aulast=Pottumarthy&rft.aufirst=Sudha&rft.date=2007-03-01&rft.volume=57&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2006.08.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Cefepime; Colony-forming cells; Inoculum; Ceftriaxone; Infection; Bactericidal activity; Minimum inhibitory concentration; Penicillin; cephems; Bacteria; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.diagmicrobio.2006.08.022 ER - TY - JOUR T1 - Viral vectors for malaria vaccine development AN - 20281468; 7640531 AB - A workshop on viral vectors for malaria vaccine development, organized by the PATH Malaria Vaccine Initiative, was held in Bethesda, MD on October 20, 2005. Recent advancements in viral-vectored malaria vaccine development and emerging vector technologies were presented and discussed. Classic viral vectors such as poxvirus, adenovirus and alphavirus vectors have been successfully used to deliver malaria antigens. Some of the vaccine candidates have demonstrated their potential in inducing malaria-specific immunity in animal models and human trials. In addition, emerging viral-vector technologies, such as measles virus (MV), vesicular stomatitis virus (VSV) and yellow fever (YF) virus, may also be useful for malaria vaccine development. Studies in animal models suggest that each viral vector is unique in its ability to induce humoral and/or cellular immune responses. Those studies have also revealed that optimization of Plasmodium genes for mammalian expression is an important aspect of vaccine design. Codon-optimization, surface-trafficking, de-glycosylation and removal of toxic domains can lead to improved immunogenicity. Understanding the vector's ability to induce an immune response and the expression of malaria antigens in mammalian cells will be critical in designing the next generation of viral-vectored malaria vaccines. JF - Vaccine AU - Li, Shengqiang AU - Locke, Emily AU - Bruder, Joseph AU - Clarke, David AU - Doolan, Denise L AU - Havenga, Menzo J E AU - Hill, Adrian V S AU - Liljestrom, Peter AU - Monath, Thomas P AU - Naim, Hussein Y AU - Ockenhouse, Christian AU - Tang, De-chu C AU - Van Kampen, Kent R AU - Viret, Jean-Francois AU - Zavala, Fidel AU - Dubovsky, Filip AD - PATH Malaria Vaccine Initiative, Bethesda, MD, USA, sheng.li@hhs.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2567 EP - 2574 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 14 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Animal models KW - Malaria KW - Measles virus KW - Expression vectors KW - Mammalian cells KW - Vesicular stomatitis virus KW - Conferences KW - Adenovirus KW - Immunity KW - Plasmodium KW - Immunogenicity KW - Poxvirus KW - Alphavirus KW - Immune response KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20281468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Viral+vectors+for+malaria+vaccine+development&rft.au=Li%2C+Shengqiang%3BLocke%2C+Emily%3BBruder%2C+Joseph%3BClarke%2C+David%3BDoolan%2C+Denise+L%3BHavenga%2C+Menzo+J+E%3BHill%2C+Adrian+V+S%3BLiljestrom%2C+Peter%3BMonath%2C+Thomas+P%3BNaim%2C+Hussein+Y%3BOckenhouse%2C+Christian%3BTang%2C+De-chu+C%3BVan+Kampen%2C+Kent+R%3BViret%2C+Jean-Francois%3BZavala%2C+Fidel%3BDubovsky%2C+Filip&rft.aulast=Li&rft.aufirst=Shengqiang&rft.date=2007-03-01&rft.volume=25&rft.issue=14&rft.spage=2567&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.07.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Plasmodium; Poxvirus; Measles virus; Alphavirus; Adenovirus; Vesicular stomatitis virus; Vaccines; Malaria; Animal models; Expression vectors; Conferences; Immunogenicity; Immune response; Mammalian cells; Immunity DO - http://dx.doi.org/10.1016/j.vaccine.2006.07.035 ER - TY - JOUR T1 - Analysis of strategies to successfully vaccinate infants in developing countries against enterotoxigenic E. coli (ETEC) disease AN - 20278964; 7640530 AB - Enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause of diarrhoea in the world, annually affecting up to 400,000,000 children under 5 years of age living in developing countries (DCs). Although ETEC possesses numerous antigens, the relatively conserved colonization factor (CF) antigens and the heat labile enterotoxin (LT) have been associated with protection and most vaccine candidates have exploited these antigens. A safe and effective vaccine against ETEC is a feasible goal as supported by the acquisition of protective immunity. The success of an ETEC vaccine targeting infants and children in DCs will depend on a combination of maximally antigenic vaccine preparations and regimens for their delivery which will produce optimal immune responses to these antigens. Vaccine candidates having a high priority for accelerated development and clinical testing for eventual use in infants would include inactivated ETEC or Shigella hybrids expressing ETEC antigens as well as attenuated ETEC strains which express the major CF antigens and LT toxin B-subunit, as well as attenuated Shigella, Vibrio cholerae and Salmonella typhi hybrids engineered to deliver antigens of ETEC. Candidates for an ETEC vaccine would have to meet the minimal requirement of providing at least 50% protection against severe disease in DCs during the first 2 years of life. The critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded and focused effort to bring it to realization. However, a Product Development Partnership to overcome this hurdle could accelerate the time lines towards when control of ETEC disease in DCs is substantially closer. JF - Vaccine AU - Walker, Richard I AU - Steele, Duncan AU - Aguado, Teresa AD - Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20851-1448, USA, walkerri@cber.fda.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2545 EP - 2566 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 14 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enterotoxigenic Escherichia coli KW - Vaccine KW - Diarrhoeal disease KW - Age KW - Diarrhea KW - Salmonella typhi KW - Shigella KW - Immunity KW - Children KW - Toxins KW - Vibrio cholerae KW - Dendritic cells KW - Heat KW - Hybrids KW - Escherichia coli KW - Enterotoxins KW - Vaccines KW - Developing countries KW - Colonization factor KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20278964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Analysis+of+strategies+to+successfully+vaccinate+infants+in+developing+countries+against+enterotoxigenic+E.+coli+%28ETEC%29+disease&rft.au=Walker%2C+Richard+I%3BSteele%2C+Duncan%3BAguado%2C+Teresa&rft.aulast=Walker&rft.aufirst=Richard&rft.date=2007-03-01&rft.volume=25&rft.issue=14&rft.spage=2545&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.12.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Diarrhea; Immunity; Children; Toxins; Dendritic cells; Heat; Hybrids; Enterotoxins; Vaccines; Developing countries; Colonization factor; Infants; Vibrio cholerae; Salmonella typhi; Escherichia coli; Shigella DO - http://dx.doi.org/10.1016/j.vaccine.2006.12.028 ER - TY - JOUR T1 - Acoustic power calibration of high-intensity focused ultrasound transducers using a radiation force technique AN - 20134906; 7431805 AB - To address the challenges associated with measuring the ultrasonic power from high-intensity focused ultrasound transducers via radiation force, a technique based on pulsed measurements was developed and analyzed. Two focused ultrasound transducers were characterized in terms of an effective duty factor, which was then used to calculate the power during the pulse at high applied power levels. Two absorbing target designs were used, and both gave comparable results and displayed no damage and minimal temperature rise if placed near the transducer and away from the focus. The method yielded reproducible results up to the maximum pulse power generated of approximately 230 W, thus allowing the radiated power to be calibrated in terms of the peak-to-peak voltage applied to the transducer. JF - Journal of the Acoustical Society of America AU - Maruvada, Subha AU - Harris, Gerald R AU - Herman, Bruce A AU - King, Randy L AD - Center for Devices and Radiological Health, Food and Drug Administration Rockville, Maryland 20850 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1434 EP - 1439 PB - Acoustical Society of America, Suite 1NO1 2 Huntington Quadrangle Melville NY 11747-4502 USA, [mailto:asa@aip.org], [URL:http://asa.aip.org/] VL - 121 IS - 3 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - alpha Radiation KW - Ultrasonics KW - Acoustics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20134906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Acoustic+power+calibration+of+high-intensity+focused+ultrasound+transducers+using+a+radiation+force+technique&rft.au=Maruvada%2C+Subha%3BHarris%2C+Gerald+R%3BHerman%2C+Bruce+A%3BKing%2C+Randy+L&rft.aulast=Maruvada&rft.aufirst=Subha&rft.date=2007-03-01&rft.volume=121&rft.issue=3&rft.spage=1434&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; alpha Radiation; Acoustics; Ultrasonics; Ultrasound ER - TY - JOUR T1 - A Novel Chimeric Plasmodium vivax Circumsporozoite Protein Induces Biologically Functional Antibodies That Recognize both VK210 and VK247 Sporozoites AN - 20110548; 7287783 AB - A successful vaccine against Plasmodium vivax malaria would significantly improve the health and quality of the lives of more than 1 billion people around the world. A subunit vaccine is the only option in the absence of long-term culture of P. vivax parasites. The circumsporozoite protein that covers the surface of Plasmodium sporozoites is one of the best-studied malarial antigens and the most promising vaccine in clinical trials. We report here the development of a novel "immunologically optimal" recombinant vaccine expressed in Escherichia coli that encodes a chimeric CS protein encompassing repeats from the two major alleles, VK210 and VK247. This molecule is widely recognized by sera from patients naturally exposed to P. vivax infection and induces a highly potent immune response in genetically disparate strains of mice. Antibodies from immunized animals recognize both VK210 and VK247 sporozoites. Furthermore, these antibodies appear to be protective in nature since they cause the agglutination of live sporozoites, an in vitro surrogate of sporozoite infectivity. These results strongly suggest that recombinant CS is biologically active and highly immunogenic across major histocompatibility complex strains and raises the prospect that in humans this vaccine may induce protective immune responses. JF - Infection and Immunity AU - Yadava, Anjali AU - Sattabongkot, Jetsumon AU - Washington, Michael A AU - Ware, Lisa A AU - Majam, Victoria AU - Zheng, Hong AU - Kumar, Sanjai AU - Ockenhouse, Christian F AD - Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910. Department of Entomology, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok 10400, Thailand. Center for Biologics Evaluation and Research, Food and Drug Administration, 5516 Nicholson Lane, Kensington, Maryland 20895 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1177 EP - 1185 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 3 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Major histocompatibility complex KW - Sporozoites KW - Plasmodium vivax KW - Malaria KW - Infection KW - Clinical trials KW - circumsporozoite protein KW - Plasmodium KW - Infectivity KW - Agglutination KW - Antibodies KW - Immunogenicity KW - Escherichia coli KW - Immune response KW - Vaccines KW - K 03350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20110548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=A+Novel+Chimeric+Plasmodium+vivax+Circumsporozoite+Protein+Induces+Biologically+Functional+Antibodies+That+Recognize+both+VK210+and+VK247+Sporozoites&rft.au=Yadava%2C+Anjali%3BSattabongkot%2C+Jetsumon%3BWashington%2C+Michael+A%3BWare%2C+Lisa+A%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BKumar%2C+Sanjai%3BOckenhouse%2C+Christian+F&rft.aulast=Yadava&rft.aufirst=Anjali&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; Sporozoites; Major histocompatibility complex; Malaria; Infection; Clinical trials; circumsporozoite protein; Antibodies; Agglutination; Infectivity; Immunogenicity; Vaccines; Immune response; Plasmodium; Escherichia coli; Plasmodium vivax ER - TY - JOUR T1 - Substrate Competition Studies Using Whole-Cell Accumulation Assays with the Major Tripartite Multidrug Efflux Pumps of Escherichia coli AN - 19972653; 7285354 AB - AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent structural studies to bind substrates at multiple sites, suggesting that particular substrate "sets" may compete for efflux by interfering with a certain binding site(s). However, our data indicate that the general structural class does not appear to dictate a particular substrate binding site that can be competitively inhibited in whole cells. In our study, substrate competition failed to increase cell-associated levels of steroids or dyes to levels characteristic of AcrB- or AcrB/EmrAB-deficient genomic mutants or achieved with the pump inhibitor carbonyl cyanide m-chlorophenylhydrazone. In addition, this general observation was sustained even with (i) a cocktail containing seven-pump substrates supplied slightly below their respective wild-type MIC levels, (ii) competing drug substrates of the same structural class (steroids or macrolides), and (iii) hyper-MIC levels of the exogenously supplied agents. Thus, this pump system (and possibly EmrAB-TolC) may have an extraordinary capacity to simultaneously handle multiple-drug substrates that is not necessarily reflected in MIC analyses. In addition, our study has extended the range of substrates recognized by the AcrAB- and EmrAB-TolC systems. JF - Antimicrobial Agents & Chemotherapy AU - Elkins, Christopher A AU - Mullis, Lisa B AD - Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas 72079-9502 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 923 EP - 929 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Data processing KW - Antibiotics KW - Steroid hormones KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Cyanide KW - Dyes KW - Inner membranes KW - Escherichia coli KW - genomics KW - carbonyls KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19972653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Substrate+Competition+Studies+Using+Whole-Cell+Accumulation+Assays+with+the+Major+Tripartite+Multidrug+Efflux+Pumps+of+Escherichia+coli&rft.au=Elkins%2C+Christopher+A%3BMullis%2C+Lisa+B&rft.aulast=Elkins&rft.aufirst=Christopher&rft.date=2007-03-01&rft.volume=51&rft.issue=3&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Cyanide; Dyes; Inner membranes; Antibiotics; genomics; Steroid hormones; Drugs; carbonyls; Minimum inhibitory concentration; Antimicrobial agents; Escherichia coli ER - TY - JOUR T1 - Polychlorinated Biphenyls and Non-Hodgkin Lymphoma AN - 19962964; 7314974 AB - Several epidemiologic studies suggest that polychlorinated biphenyl (PCB) levels measured in peripheral blood or adipose tissue are related to increased risk of non-Hodgkin lymphoma (NHL) and, therefore, may be at least partially responsible for the rising incidence of NHL unrelated to HIV infection in recent decades. Case-control studies that measured PCBs in blood, adipose tissue, or household carpet dust, at the time of diagnosis, have observed elevated NHL risk associated with concentrations of either total PCBs or of specific congeners. Similar associations have been found in a number of prospective cohorts. These associations do not seem to be due to confounding by other organochlorines or by other known NHL risk factors. These results support evidence of PCB carcinogenicity from animal studies. However, interpretation of the epidemiologic evidence is limited by the wide range in measurement precision across congeners and by the moderate to high correlation among many congeners. Occupational cohort studies provide very limited support for a relationship between PCBs and NHL. In conclusion, there is mounting evidence of a relationship between certain PCBs and risk of NHL, but important questions remain, especially regarding the magnitude, timing, and causality of that relationship. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):373-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Engel, Lawrence S AU - Lan, Qing AU - Rothman, Nathaniel AD - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York and Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 373 EP - 376 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - HIV KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Organochlorine compounds KW - adipose tissues KW - Infection KW - Dust KW - households KW - Carpets KW - Carcinogenicity KW - Risk factors KW - infection KW - prevention KW - Congeners KW - PCB compounds KW - Lymphoma KW - PCB KW - Bioindicators KW - Peripheral blood KW - biomarkers KW - Cancer KW - polychlorinated biphenyls KW - Human immunodeficiency virus KW - Adipose tissue KW - lymphoma KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polychlorinated+Biphenyls+and+Non-Hodgkin+Lymphoma&rft.au=Engel%2C+Lawrence+S%3BLan%2C+Qing%3BRothman%2C+Nathaniel&rft.aulast=Engel&rft.aufirst=Lawrence&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Organochlorine compounds; Peripheral blood; Infection; biomarkers; Dust; Cancer; polychlorinated biphenyls; Carcinogenicity; Carpets; Risk factors; Congeners; Adipose tissue; Lymphoma; PCB; Bioindicators; households; prevention; infection; adipose tissues; lymphoma; PCB compounds; Human immunodeficiency virus ER - TY - JOUR T1 - Effects of vibration on grip and push force-recall performance AN - 19781164; 7385495 AB - Comprehensive assessments of health risks associated with the operation of vibratory tools should include evaluations of hand-tool coupling forces. The use of hand-force instrumentation in field applications can be difficult and expensive. A previous study (McDowell, T.W., Wiker, S.F., Dong, R.G., Welcome, D.E., Schopper, A.W., 2006. Evaluation of psychometric estimates of vibratory hand-tool grip and push forces. International Journal of Industrial Ergonomics 36(2), 119-128.) examined various combinations of handle vibration frequencies and grip and push force levels upon ones ability to recall those forces using psychophysical methods. The results of that study were promising. The present study is a follow-up experiment that further investigated the potential for using psychophysical force-recall methods to estimate grip and push forces when operating powered hand tools. In this experiment, 20 subjects (10 male, 10 female) grasped and pushed an instrumented handle for 45 s at one of three force levels while it vibrated sinusoidally at one of four frequencies (16, 31.5, 63, or 125 Hz) or with no vibration. Unlike the first study, two levels of vibration magnitude were examined along with gender differences. This study further clarifies relationships between vibration exposure characteristics and their effects on grip and push force-recall performance. Vibration exposure conditions and other influential factors can be accounted for in enhanced force-recall methodologies that can be incorporated into a variety of workplace exposure assessment applications.