TY - CPAPER T1 - Confirmation and Quantitation of Peanut Allergens in Foods by Mass Spectrometry T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39226801; 4354826 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Musser, Steven M AU - Shefcheck, Kevin J AU - Callahan, John H Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Mass spectroscopy KW - Allergens KW - Food KW - Nuts KW - Quantitation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39226801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Confirmation+and+Quantitation+of+Peanut+Allergens+in+Foods+by+Mass+Spectrometry&rft.au=Musser%2C+Steven+M%3BShefcheck%2C+Kevin+J%3BCallahan%2C+John+H&rft.aulast=Musser&rft.aufirst=Steven&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Mycotoxins in Botanical Roots and Finished Products T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39207909; 4354925 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Trucksess, Mary W AU - Weaver, Carol M AU - Oles, Carolyn J AU - Rader, Jeanne I Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Mycotoxins KW - Roots KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39207909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Determination+of+Mycotoxins+in+Botanical+Roots+and+Finished+Products&rft.au=Trucksess%2C+Mary+W%3BWeaver%2C+Carol+M%3BOles%2C+Carolyn+J%3BRader%2C+Jeanne+I&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Allergens: Methods of Detection and the Importance of Validation T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39174597; 4354820 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Garber, Eric A.E. Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Allergens KW - Food hypersensitivity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39174597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Food+Allergens%3A+Methods+of+Detection+and+the+Importance+of+Validation&rft.au=Garber%2C+Eric+A.E.&rft.aulast=Garber&rft.aufirst=Eric&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The US Orphan Drug Act: Benefits to Patients, Benefits to Community T2 - Second Eastern European Conference on Rare Diseases and Orphan Drugs AN - 40409429; 4449181 JF - Second Eastern European Conference on Rare Diseases and Orphan Drugs AU - Haffner, Marlene E Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40409429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Eastern+European+Conference+on+Rare+Diseases+and+Orphan+Drugs&rft.atitle=The+US+Orphan+Drug+Act%3A+Benefits+to+Patients%2C+Benefits+to+Community&rft.au=Haffner%2C+Marlene+E&rft.aulast=Haffner&rft.aufirst=Marlene&rft.date=2006-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Eastern+European+Conference+on+Rare+Diseases+and+Orphan+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.conf2006.raredis.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gender and Age Differences in Posttraumatic Stress Disorder and Depression Among Buffalo Police Officers AN - 877591961; 13617252 AB - Because of the stressful nature of police work, officers may be at increased risk for posttraumatic stress disorder (PTSD) and depression. The Impact of Event Scale (IES) and Center for Epidemiologic Studies-Depression (CES-D) survey were administered to 100 officers. Mean IES and CES-D scores and prevalence of PTSD and depression were compared across gender and age. Female officers had higher mean IES and CES-D scores than male officers. Mean CES-D scores tended to increase with age, whereas mean IES scores varied little across age. Prevalence of depression was greater among women (22.0%) than men (12.1%), yet differences were less evident for PTSD (36.6% women, 34.5% men). Depression and PTSD tended to increase with age and were not explained by gender, marital status, or education. JF - Traumatology AU - Darensburg, Tahera AU - Andrew, Michael E AU - Hartley, Tara A AU - Burchfiel, Cecil M AU - Fekedulegn, Desta AU - Violanti, John M AD - Rollins School of Public Health, Emory University; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, cburchfiel@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 220 EP - 228 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 3 SN - 1534-7656, 1534-7656 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877591961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Gender+and+Age+Differences+in+Posttraumatic+Stress+Disorder+and+Depression+Among+Buffalo+Police+Officers&rft.au=Darensburg%2C+Tahera%3BAndrew%2C+Michael+E%3BHartley%2C+Tara+A%3BBurchfiel%2C+Cecil+M%3BFekedulegn%2C+Desta%3BViolanti%2C+John+M&rft.aulast=Darensburg&rft.aufirst=Tahera&rft.date=2006-09-01&rft.volume=12&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765606296271 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/1534765606296271 ER - TY - JOUR T1 - Unrestrained Acoustic Plethysmograph for Measuring Tidal Volume in Mice AN - 831174421; 13866787 AB - The traditional method for measurement of tidal volume in unrestrained mice relies on pressure changes induced by a freely respiring animal in a whole body plethysmograph. These changes have been assumed to be the result of thermo-hygrometric differences between respired air and gas within the chamber. It is known, however, that gas compression in the lung can also contribute significantly to changes in plethysmograph pressure. This study describes an acoustic plethysmograph for mice that is capable of measuring the tidal volume time series without the errors associated with the traditional method. The plethysmograph was designed as a resonating cavity at a fixed frequency. It had a sharp resonant peak and was tuned so that changes in body volume produced nearly linear changes in sound amplitude. The plethysmograph was tested with a water filled balloon connected to a syringe pump. The volume of the balloon was varied as a triangle wave with an amplitude of 250kL. The RMS error between measured and delivered volume was 4.43kL. A volume step test, performed to assess the response time of the system, showed that the plethysmograph responded in less than one millisecond. JF - Annals of Biomedical Engineering AU - Reynolds, Jeffrey S AU - Frazer, David G AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, jsr0@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1494 EP - 1499 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 34 IS - 9 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Cavities KW - Acoustics KW - Lung KW - Sound KW - Syringes KW - Waves KW - Pressure KW - Balloons KW - Compression KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831174421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Unrestrained+Acoustic+Plethysmograph+for+Measuring+Tidal+Volume+in+Mice&rft.au=Reynolds%2C+Jeffrey+S%3BFrazer%2C+David+G&rft.aulast=Reynolds&rft.aufirst=Jeffrey&rft.date=2006-09-01&rft.volume=34&rft.issue=9&rft.spage=1494&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-006-9159-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Cavities; Lung; Acoustics; Sound; Syringes; Waves; Pressure; Compression; Balloons DO - http://dx.doi.org/10.1007/s10439-006-9159-8 ER - TY - JOUR T1 - Single-laboratory validation of a method for the determination of furan in foods by using static headspace sampling and gas chromatography/mass spectrometry. AN - 68963501; 17042194 AB - A headspace gas chromatography/mass spectrometry method was developed and validated in-house for the determination of furan in foods. The method of standard additions with d4-furan as the internal standard was used to quantitate furan. The limit of detection and limit of quantitation (LOQ) values ranged from 0.2 and 0.6 nglg, respectively, in apple juice to 0.9 and 2.9 ng/g, respectively, in peanut butter. Recoveries were obtained at 0.5, 1, 2, and 3 times the LOQ. At 1, 2, and 3 times the LOQ, the recoveries ranged from 89.4 to 108%, and the relative standard deviations ranged from 3.3 to 17.3% for all the matrixes. For apple juice, chicken broth, and infant formula, the averaged coefficients of determination from the linear regression analyses were >0.99 with each food fortified at 0.5, 1, 2, and 3 times the LOQ. The coefficients of determination were >0.99 for green beans and 0.96 for peanut butter with the foods fortified at 1, 2, and 3 times the LOQ. Within-laboratory precision was determined by comparing the amounts of furan found in 18 samples by 2 analysts on different days with different instruments. For most of the foods, the difference between the amounts found by each analyst was 300 foods. The furan levels found ranged from none detected to 174 ng/g. JF - Journal of AOAC International AU - Nyman, Patricia J AU - Morehouse, Kim M AU - McNeal, Timothy P AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. patricia.nyman@fda.hhs.gov PY - 2006 SP - 1417 EP - 1424 VL - 89 IS - 5 SN - 1060-3271, 1060-3271 KW - Carcinogens KW - 0 KW - Furans KW - Index Medicus KW - Reproducibility of Results KW - Carcinogens -- standards KW - Reference Standards KW - Carcinogens -- analysis KW - Food Analysis -- statistics & numerical data KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Furans -- standards KW - Food Contamination -- statistics & numerical data KW - Food Contamination -- analysis KW - Gas Chromatography-Mass Spectrometry -- statistics & numerical data KW - Gas Chromatography-Mass Spectrometry -- standards KW - Furans -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68963501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Single-laboratory+validation+of+a+method+for+the+determination+of+furan+in+foods+by+using+static+headspace+sampling+and+gas+chromatography%2Fmass+spectrometry.&rft.au=Nyman%2C+Patricia+J%3BMorehouse%2C+Kim+M%3BMcNeal%2C+Timothy+P%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Two rapid methods for detection of Escherichia coli exceeding 10(4)/g action levels: precollaborative study. AN - 68963318; 17042182 AB - The current AOAC Method 966.24 for enumeration of Escherichia coli in foods uses a most probable number (MPN) procedure with extensive confirmation steps. Two new methods based on membrane filtration (MF) were compared to the MPN reference method for detection of high levels of E. coli in 5 food types, some of which represent categories for which the U.S. Food and Drug Administration (FDA) mandates additional testing if an action level of 10(4)/g E. coli is exceeded. Ground beef, which is not FDA regulated, was also tested. The 5 food types were all inoculated at 3 levels: 10(2)/g, > or = 10(4)/g, and > or = 10(5)/g E. coli. An MF protocol using either m-ColiBlue24 (CB) or lauryl sulfate tryptose plus BCIG (LST/BCIG) was an effective potential alternative to the reference method. Sensitivity and specificity for both CB and LST/BCIG were 98 and 100%, respectively. Agreement between MPN and both CB and LST/BCIG was 98%. The 2 proposed methods allow completion of both presumptive and confirmatory steps in 1-3 days, whereas the reference method requires as many as 11 days. Exclusivity testing with 50 non-E. coli strains indicated 100% were correctly ruled out by the proposed protocols. Inclusivity testing was used to determine whether typical results were obtained after incubation of E. coli cultures on CB or LST/BCIG for 24 h. Of 50 E. coli strains tested, 100% yielded typical results after incubation on CB, and 98% yielded typical results after incubation on LST/BCIG. JF - Journal of AOAC International AU - Grant, Michael A AU - Wernberg, Jane S AU - Van, Khanh T AU - Albert, Angelina M AD - U.S. Food and Drug Administration, Pacific Regional Laboratory, Northwest, Bothell, WA 98021, USA. mike.grant@fda.hhs.gov PY - 2006 SP - 1317 EP - 1326 VL - 89 IS - 5 SN - 1060-3271, 1060-3271 KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Filtration -- methods KW - Cooperative Behavior KW - United States Food and Drug Administration KW - Time Factors KW - Food Microbiology -- standards KW - Colony Count, Microbial -- methods KW - Escherichia coli -- isolation & purification KW - Colony Count, Microbial -- statistics & numerical data KW - Colony Count, Microbial -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68963318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Two+rapid+methods+for+detection+of+Escherichia+coli+exceeding+10%284%29%2Fg+action+levels%3A+precollaborative+study.&rft.au=Grant%2C+Michael+A%3BWernberg%2C+Jane+S%3BVan%2C+Khanh+T%3BAlbert%2C+Angelina+M&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial personality disorder with childhood- vs. adolescence-onset conduct disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68851074; 16971818 AB - This study, based on a nationally representative, epidemiologic sample (N = 43,093, response rate 81%), compared sociodemographic and family history correlates, antisocial personality disorder (ASPD) symptom patterns, and Axis I and Axis II comorbidity, among adults with DSM-IV ASPD who reported onset of conduct disorder (CD) in childhood ( or =age 10). Prevalence of each ASPD diagnostic criterion and comorbid lifetime disorder was estimated. Logistic regression was used to examine associations of childhood-onset CD with ASPD symptom patterns and comorbid disorders. Among the 1422 respondents with ASPD, 447 reported childhood-onset CD. Childhood-onset respondents were more likely than adolescence-onset respondents to endorse CD criteria involving aggression against persons, animals, and property before age 15, and to endorse more childhood criteria and lifetime violent behaviors. Childhood-onset respondents displayed significantly elevated odds of lifetime social phobia, generalized anxiety disorder, drug dependence, and paranoid, schizoid, and avoidant personality disorders, but significantly decreased odds for lifetime tobacco dependence. Childhood-onset CD appears to identify a more polysymptomatic and violent form of ASPD, associated with greater lifetime comorbidity for selected Axis I and Axis II disorders, in nonclinical populations. JF - The Journal of nervous and mental disease AU - Goldstein, Risë B AU - Grant, Bridget F AU - Ruan, W June AU - Smith, Sharon M AU - Saha, Tulshi D AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 667 EP - 675 VL - 194 IS - 9 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Violence -- statistics & numerical data KW - Age of Onset KW - Mental Disorders -- epidemiology KW - Humans KW - Mental Disorders -- psychology KW - Child KW - Comorbidity KW - Cross-Sectional Studies KW - Mental Disorders -- diagnosis KW - Logistic Models KW - Adult KW - Health Surveys KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Violence -- psychology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Alcohol-Related Disorders -- epidemiology KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Conduct Disorder -- epidemiology KW - Conduct Disorder -- psychology KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68851074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Antisocial+personality+disorder+with+childhood-+vs.+adolescence-onset+conduct+disorder%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F%3BRuan%2C+W+June%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2006-09-01&rft.volume=194&rft.issue=9&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-13 N1 - Date created - 2006-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Nerv Ment Dis. 2008 Mar;196(3):263 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transformation of the antibacterial agent norfloxacin by environmental mycobacteria. AN - 68837059; 16957195 AB - Because fluoroquinolone antimicrobial agents may be released into the environment, the potential for environmental bacteria to biotransform these drugs was investigated. Eight Mycobacterium sp. cultures in a sorbitol-yeast extract medium were dosed with 100 microg ml(-1) of norfloxacin and incubated for 7 days. The MICs of norfloxacin for these strains, tested by an agar dilution method, were 1.6 to 25 microg ml(-1). Cultures were extracted with ethyl acetate, and potential metabolites in the extracts were purified by high-performance liquid chromatography. The metabolites were identified using mass spectrometry and nuclear magnetic resonance spectroscopy. N-Acetylnorfloxacin (5 to 50% of the total absorbance at 280 nm) was produced by the eight Mycobacterium strains. N-Nitrosonorfloxacin (5 to 30% of the total absorbance) was also produced by Mycobacterium sp. strain PYR100 and Mycobacterium gilvum PYR-GCK. The MICs of N-nitrosonorfloxacin and N-acetylnorfloxacin were 2- to 38- and 4- to 1,000-fold higher, respectively, than those of norfloxacin for several different bacteria, including the two strains that produced both metabolites. Although N-nitrosonorfloxacin had less antibacterial activity, nitrosamines are potentially carcinogenic. The biotransformation of fluoroquinolones by mycobacteria may serve as a resistance mechanism. JF - Applied and environmental microbiology AU - Adjei, Michael D AU - Heinze, Thomas M AU - Deck, Joanna AU - Freeman, James P AU - Williams, Anna J AU - Sutherland, John B AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5790 EP - 5793 VL - 72 IS - 9 SN - 0099-2240, 0099-2240 KW - Anti-Bacterial Agents KW - 0 KW - Environmental Pollutants KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Environmental Pollutants -- metabolism KW - Biotransformation KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Environmental Microbiology KW - Anti-Bacterial Agents -- metabolism KW - Norfloxacin -- pharmacology KW - Mycobacterium -- drug effects KW - Anti-Bacterial Agents -- chemistry KW - Mycobacterium -- metabolism KW - Mycobacterium -- isolation & purification KW - Anti-Bacterial Agents -- pharmacology KW - Norfloxacin -- metabolism KW - Norfloxacin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68837059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Transformation+of+the+antibacterial+agent+norfloxacin+by+environmental+mycobacteria.&rft.au=Adjei%2C+Michael+D%3BHeinze%2C+Thomas+M%3BDeck%2C+Joanna%3BFreeman%2C+James+P%3BWilliams%2C+Anna+J%3BSutherland%2C+John+B&rft.aulast=Adjei&rft.aufirst=Michael&rft.date=2006-09-01&rft.volume=72&rft.issue=9&rft.spage=5790&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-09-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Ind Microbiol Biotechnol. 2001 Mar;26(3):140-4 [11420653] Nat Med. 2006 Jan;12(1):83-8 [16369542] Int J Syst Evol Microbiol. 2001 Sep;51(Pt 5):1715-22 [11594601] J Antimicrob Chemother. 2001 Dec;48(6):895-901 [11733475] Vet Res Commun. 2001 Dec;25(8):641-9 [11767010] Arch Biochem Biophys. 2003 Aug 15;416(2):209-17 [12893299] J Agric Food Chem. 2004 Jun 2;52(11):3473-7 [15161218] Nat Rev Microbiol. 2004 Jul;2(7):593-602 [15197394] Antimicrob Agents Chemother. 2004 Jul;48(7):2415-23 [15215089] Appl Environ Microbiol. 2004 Oct;70(10):6005-11 [15466544] Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 May 20;89(1):69-73 [141802] J Pharm Sci. 1984 Jan;73(1):99-102 [6229625] Eur J Clin Microbiol. 1987 Oct;6(5):584-6 [3125050] J Gen Microbiol. 1988 Jan;134(1):221-6 [3141563] Appl Environ Microbiol. 1988 Oct;54(10):2549-55 [3202633] Anal Chem. 2001 Aug 1;73(15):3632-8 [11510827] Mol Microbiol. 1990 Nov;4(11):1911-9 [2082148] Appl Environ Microbiol. 1993 Jun;59(6):1927-30 [8328808] Antimicrob Agents Chemother. 1994 Apr;38(4):773-80 [8031045] Appl Environ Microbiol. 1996 Jan;62(1):13-9 [8572690] Carcinogenesis. 1996 Mar;17(3):533-6 [8631140] Appl Microbiol Biotechnol. 1996 Oct;46(3):307-12 [8933844] Carcinogenesis. 1997 Feb;18(2):383-9 [9054633] Appl Environ Microbiol. 1997 Nov;63(11):4272-81 [9361414] J Ind Microbiol Biotechnol. 1997 Nov-Dec;19(5-6):378-84 [9451835] Antimicrob Agents Chemother. 1998 Apr;42(4):795-800 [9559785] Br Poult Sci. 1998 Mar;39(1):42-6 [9568297] J Bacteriol. 1999 Feb;181(4):1343-7 [9973365] Mutat Res. 1999 Jul 15;443(1-2):129-38 [10415436] FEMS Microbiol Lett. 1999 Aug 1;177(1):131-5 [10436931] J Control Release. 2005 Jan 3;101(1-3):343-5 [15838943] Adv Drug Deliv Rev. 2005 Jul 29;57(10):1451-70 [15950313] Microb Ecol. 2005 Jul;50(1):110-9 [16132428] Appl Microbiol Biotechnol. 2001 Aug;56(3-4):474-7 [11549022] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Waste incineration--how big is the health risk? A quantitative method to allow comparison with other health risks. AN - 68816874; 16868310 AB - To assess the health risk from a medium-sized waste incinerator and develop a single comparable figure to quantify overall risk. We used a prospective health risk assessment utilizing US Environmental Protection Agency Human Health Risk Assessment Protocol (HHRAP) for Hazardous Waste Combustion Facilities and UK coefficients for the impact of sulphur dioxide and particulates. Calculations were based on a resident population of 25,398 living within 5.5 km of the site. Anxiety, employment, noise, occupational risks, road accidents, and reduced use of landfill were all considered to have a potential, but unquantifiable, effect on health. Stack emissions over 25 years in a population of 25,398 within 5.5 km of the stack would result in an additional 0.018 cancers, 0.46 deaths brought forward due to sulphur dioxide and 0.02 deaths due to fine particles. The overall risk of dying due to emissions in any one year was 2.49 x 10(-7) or 1 in 4 million. To facilitate better public understanding of the comparative risk of incinerator emissions, we propose a simple method of deriving a single annual risk figure allowing comparison with the risk of dying from other causes with which the public is more familiar. JF - Journal of public health (Oxford, England) AU - Roberts, Richard J AU - Chen, Mengfang AD - National Public Health Service for Wales, Abton House, Wedal Road, Cardiff, CF14 3QX, UK. richard.roberts@nphs.wales.nhs.uk Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 261 EP - 266 VL - 28 IS - 3 SN - 1741-3842, 1741-3842 KW - Air Pollutants KW - 0 KW - Carcinogens KW - Dioxins KW - Hazardous Waste KW - Index Medicus KW - Humans KW - Carcinogens -- toxicity KW - Wales KW - Dioxins -- toxicity KW - Air Pollutants -- toxicity KW - Incineration KW - Hazardous Waste -- adverse effects KW - Air Pollution -- adverse effects KW - Environmental Exposure -- adverse effects KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+public+health+%28Oxford%2C+England%29&rft.atitle=Waste+incineration--how+big+is+the+health+risk%3F+A+quantitative+method+to+allow+comparison+with+other+health+risks.&rft.au=Roberts%2C+Richard+J%3BChen%2C+Mengfang&rft.aulast=Roberts&rft.aufirst=Richard&rft.date=2006-09-01&rft.volume=27&rft.issue=8&rft.spage=1713&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation. AN - 68769122; 16546258 AB - Serious questions have been raised regarding a possible causal association between neurological effects in welders and the presence of manganese in welding fume. An experimental model is needed that could examine the potential neurotoxic effect of manganese after pulmonary exposure to welding fume. The National Institute for Occupational Safety and Health (NIOSH) has recently finished construction of a completely automated, computer controlled welding fume generation and inhalation exposure system for laboratory animals. The system is comprised of a programmable six-axis robotic welding arm and a water-cooled arc welding torch. A flexible trunk has been attached to the robotic arm of the welder and is used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Preliminary fume characterization studies have indicated that particle morphology, size, and chemical composition were comparable to welding fume generated in the workplace. Animal inhalation studies are currently underway. With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system. JF - Neurotoxicology AU - Antonini, James M AU - O'Callaghan, James P AU - Miller, Diane B AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. jga6@cdc.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 745 EP - 751 VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Models, Animal KW - Neurotoxicity Syndromes -- etiology KW - Welding KW - Neurotoxicity Syndromes -- physiopathology KW - Air Pollutants, Occupational -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68769122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Development+of+an+animal+model+to+study+the+potential+neurotoxic+effects+associated+with+welding+fume+inhalation.&rft.au=Antonini%2C+James+M%3BO%27Callaghan%2C+James+P%3BMiller%2C+Diane+B&rft.aulast=Antonini&rft.aufirst=James&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analytical model for residual stresses in polymeric containers during cryogenic storage of hematopoietic stem cells. AN - 68734131; 16844438 AB - Hematopoietic stem cell (HSC) therapy can significantly lower instances of infection in chemotherapy patients by accelerating the recovery of white blood cells in the body. However, therapy requires that HSCs be stored at cryogenic temperatures to retain the cells' ability to proliferate. Currently, cells are stored in polymeric blood bags that are subject to fracture at the extremely low storage temperatures, which leads to cell contamination, thereby reducing their effectiveness. Therefore, we have developed an analytical model to predict the accumulation of stresses that ultimately lead to crack initiation and bag fracture during cryogenic storage. Our model gives explicit relationships between stress state in the container and thermoelastic properties of the container material, container geometry, and environmental factors that include temperature of the system and pressure induced by excess gas evolving from the stored medium. Predictions based on the model are consistent with experimental observations of bag failures that occurred during cryogenic storage applications. Finally, the model can provide guidance in material selection and bag design to fabricate bags that will be less susceptible to fracture. JF - Acta biomaterialia AU - Saylor, David M AU - McDermott, Martin K AU - Fuller, Edwin R AD - Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Rockville, MD 20852, USA. david.saylor@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 537 EP - 546 VL - 2 IS - 5 SN - 1742-7061, 1742-7061 KW - Antineoplastic Agents KW - 0 KW - Biocompatible Materials KW - Polymers KW - Index Medicus KW - Neoplasms -- drug therapy KW - Humans KW - Transplantation, Autologous KW - Neoplasms -- therapy KW - Antineoplastic Agents -- adverse effects KW - Equipment Design KW - Leukopenia -- chemically induced KW - Stress, Mechanical KW - In Vitro Techniques KW - Hematopoietic Stem Cell Transplantation KW - Materials Testing KW - Elasticity KW - Leukopenia -- therapy KW - Models, Theoretical KW - Cryopreservation -- instrumentation KW - Hematopoietic Stem Cells KW - Cryopreservation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68734131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+biomaterialia&rft.atitle=Analytical+model+for+residual+stresses+in+polymeric+containers+during+cryogenic+storage+of+hematopoietic+stem+cells.&rft.au=Saylor%2C+David+M%3BMcDermott%2C+Martin+K%3BFuller%2C+Edwin+R&rft.aulast=Saylor&rft.aufirst=David&rft.date=2006-09-01&rft.volume=2&rft.issue=5&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Acta+biomaterialia&rft.issn=17427061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-17 N1 - Date created - 2006-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. AN - 68721110; 16489464 AB - We performed a 28-day repeated-dose toxicity study of vinclozolin, a widely used fungicide, based on the draft protocol of the "Enhanced OECD Test Guideline 407" (Enhanced TG407) to investigate whether vinclozolin has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with vinclozolin daily by oral gavage at dose rates of 0, 3.125, 12.5, 50 and 200 mg/kg/day for at least 28 days. The vinclozolin-treated male rats showed a reduction of epididymis and accessory sex organ weights and an alteration of hormonal patterns. A slight prolongation of the estrous cycle and changes in the estrogen/testosterone ratio and luteinizing hormone level were observed in vinclozolin-treated female rats. Thyroxin concentrations were decreased and thyroid-stimulating hormone concentrations were increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of vinclozolin could be detected by the parameters examined in the present study based on the OECD protocol, suggesting the Enhanced TG407 protocol should be a suitable screening test for the detection of endocrine-mediated effects of chemicals. JF - Archives of toxicology AU - Shin, Jae-Ho AU - Moon, Hyun Ju AU - Kim, Tae Sung AU - Kang, Il Hyun AU - Ki, Ho Yeon AU - Choi, Kwang Sik AU - Han, Soon Young AD - Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Korea. jaehoshin@hanmir.com Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 547 EP - 554 VL - 80 IS - 9 SN - 0340-5761, 0340-5761 KW - Androgen Antagonists KW - 0 KW - Estrogens KW - Fungicides, Industrial KW - Oxazoles KW - Testosterone KW - 3XMK78S47O KW - Luteinizing Hormone KW - 9002-67-9 KW - Thyrotropin KW - 9002-71-5 KW - vinclozolin KW - JJ258EZN1I KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Thyrotropin -- blood KW - Dose-Response Relationship, Drug KW - Thyroxine -- blood KW - Estrous Cycle -- blood KW - Estrous Cycle -- drug effects KW - Estrogens -- blood KW - Rats KW - Rats, Sprague-Dawley KW - European Union KW - Testosterone -- blood KW - Guidelines as Topic KW - Luteinizing Hormone -- blood KW - Female KW - Male KW - Androgen Antagonists -- toxicity KW - Genitalia, Male -- drug effects KW - Genitalia, Male -- pathology KW - Toxicity Tests -- methods KW - Fungicides, Industrial -- toxicity KW - Oxazoles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68721110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Repeated+28-day+oral+toxicity+study+of+vinclozolin+in+rats+based+on+the+draft+protocol+for+the+%22Enhanced+OECD+Test+Guideline+No.+407%22+to+detect+endocrine+effects.&rft.au=Shin%2C+Jae-Ho%3BMoon%2C+Hyun+Ju%3BKim%2C+Tae+Sung%3BKang%2C+Il+Hyun%3BKi%2C+Ho+Yeon%3BChoi%2C+Kwang+Sik%3BHan%2C+Soon+Young&rft.aulast=Shin&rft.aufirst=Jae-Ho&rft.date=2006-09-01&rft.volume=80&rft.issue=9&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relation of body mass index to cancer risk in 362,552 Swedish men. AN - 68637311; 16841257 AB - Obesity has been linked with increased risk for cancers of the colon, kidney, breast, endometrium and gallbladder. For other cancer sites, the relationship with obesity is less well quantified, and the effect of weight change on cancer risk is unclear. We examined the health records of 362,552 Swedish men who underwent at least one physical examination from 1971 to 1992, and were followed until death or the end of 1999. Incident cancer cases were identified by linkage to the Swedish cancer registry. Poisson regression models were used to estimate relative risks of cancer for both body-mass index (BMI) at baseline exam and, in a subgroup of 107,815 men, change in BMI after six years of follow-up, adjusting for age and smoking status. Compared to men of normal weight, obese men had a significantly increased risk of all cancers combined (RR = 1.1; 95% CI = 1.0-1.2). The risks were most pronounced for esophageal adenocarcinoma (RR = 2.7; 95% CI = 1.3-5.6), renal cell carcinoma (RR = 1.8; 95% CI = 1.4-2.4), malignant melanoma (RR = 1.4; 95% CI = 1.1-1.7), and cancers of the colon (RR = 1.7; 95% CI = 1.5-2.0), rectum (RR = 1.4; 95% CI = 1.1-1.7), and liver (RR = 3.6; 95% CI = 2.6-5.0). Risk of esophageal squamous cell carcinoma was elevated for underweight men whose BMI was less than 18.5 (RR = 3.1; 95% CI = 1.1-8.3). An excess risk for cancers of the pancreas and connective tissue was observed only among nonsmokers. Compared to men whose weight remained stable, men with more than a 15% increase in BMI after six years of follow-up had an elevated risk of pancreas and renal cell cancers. Obesity and weight gain increase the risk for several forms of cancer in men, and underscore the need for further study into carcinogenic mechanisms and preventive interventions. JF - Cancer causes & control : CCC AU - Samanic, Claudine AU - Chow, Wong-Ho AU - Gridley, Gloria AU - Jarvholm, Bengt AU - Fraumeni, Joseph F AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Room 8115, Bethesda, MD 20892, USA. samanicc@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 901 EP - 909 VL - 17 IS - 7 SN - 0957-5243, 0957-5243 KW - Index Medicus KW - Waist-Hip Ratio KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Sweden -- epidemiology KW - Middle Aged KW - Follow-Up Studies KW - Weight Gain KW - Male KW - Obesity -- complications KW - Neoplasms -- epidemiology KW - Body Mass Index KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68637311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Volatile+organic+compounds+and+pulmonary+function+in+the+Third+National+Health+and+Nutrition+Examination+Survey%2C+1988-1994.&rft.au=Elliott%2C+Leslie%3BLongnecker%2C+Matthew+P%3BKissling%2C+Grace+E%3BLondon%2C+Stephanie+J&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung dosimetry and risk assessment of nanoparticles: evaluating and extending current models in rats and humans. AN - 68077629; 16774860 AB - Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment for species differences in the relationship between airborne exposure and internal dose. Another approach is lung dosimetry modeling, which provides a biologically-based, mechanistic method to extrapolate doses from animals to humans. However, current mass-based lung dosimetry models may not fully account for differences in the clearance and translocation of nanoparticles. In this article, key steps in quantitative risk assessment are illustrated, using dose-response data in rats chronically exposed to either fine or ultrafine titanium dioxide (TiO2), carbon black (CB), or diesel exhaust particulate (DEP). The rat-based estimates of the working lifetime airborne concentrations associated with 0.1% excess risk of lung cancer are approximately 0.07 to 0.3 mg/m3 for ultrafine TiO2, CB, or DEP, and 0.7 to 1.3 mg/m3 for fine TiO2. Comparison of observed versus model-predicted lung burdens in rats shows that the dosimetry models predict reasonably well the retained mass lung burdens of fine or ultrafine poorly soluble particles in rats exposed by chronic inhalation. Additional model validation is needed for nanoparticles of varying characteristics, as well as extension of these models to include particle translocation to organs beyond the lungs. Such analyses would provide improved prediction of nanoparticle dose for risk assessment. JF - Inhalation toxicology AU - Kuempel, E D AU - Tran, C L AU - Castranova, V AU - Bailer, A J AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. ekuempel@cdc.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 717 EP - 724 VL - 18 IS - 10 KW - Air Pollutants, Occupational KW - 0 KW - Soot KW - Vehicle Emissions KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Rats KW - Animals KW - Vehicle Emissions -- toxicity KW - Dose-Response Relationship, Drug KW - Humans KW - Species Specificity KW - Likelihood Functions KW - Risk Assessment KW - Titanium -- toxicity KW - Soot -- toxicity KW - Soot -- pharmacokinetics KW - Air Pollutants, Occupational -- toxicity KW - Lung -- metabolism KW - Soot -- chemistry KW - Air Pollutants, Occupational -- chemistry KW - Models, Biological KW - Nanoparticles KW - Lung Neoplasms -- etiology KW - Titanium -- chemistry KW - Lung -- drug effects KW - Air Pollutants, Occupational -- pharmacokinetics KW - Titanium -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68077629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+dosimetry+and+risk+assessment+of+nanoparticles%3A+evaluating+and+extending+current+models+in+rats+and+humans.&rft.au=Kuempel%2C+E+D%3BTran%2C+C+L%3BCastranova%2C+V%3BBailer%2C+A+J&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2006-09-01&rft.volume=18&rft.issue=10&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2006-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Inhal Toxicol. 2007 Feb;19(2):195; author reply 197-8 [17169866] N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - NIH News in Health: September 2006 AN - 62032145; ED495342 AB - News in Health, is a monthly newsletter that provides practical health news and information. As college students arrive on campus this fall, it is a time of new experiences, new friendships and making memories that will last a lifetime. Unfortunately for many, it can also be a time of excessive drinking and dealing with its aftermath--vandalism, violence, sexual aggression and even death. For those beginning their college experience, a rapid increase in heavy drinking over a relatively short period of time can cause serious problems with the transition to college. This period is also marked by taking risks. This can include risky drinking and early drinking is associated with other risky behavior, such as academic failure, unsafe sexual behavior and drug use. This issue contains the following articles: (1) Discussing Drinking: A Back-to-School Conversation You Need to Have; (2) Drugs are a Drag: Help Your Child Avoid Drugs of Abuse; (3) Stay Skeptical about Genetic Testing; (4) Get Active for a Healthy Heart; and (5) Web Site: College Drinking. AU - Wein, Harrison Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 4 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Higher Education KW - At Risk Persons KW - Alcohol Abuse KW - College Students KW - Definitions KW - Drug Education KW - Mental Health KW - Narcotics KW - Newsletters KW - Scholastic Journalism KW - Behavior Problems KW - Screening Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62032145?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Workplace Violence Prevention Strategies and Research Needs AN - 58753145; 2007-20606 AB - Since the 1980s, violence has been recognized as a leading cause of occupational mortality and morbidity. On average, 1.7 million workers are injured each year, and more than 800 die as a result of workplace violence (WPV). These tragic deaths and injuries stress the need for a proactive and collaborative WPV prevention effort at the national level. In November 2004, NIOSH organized a conference seeking a reduction in the toll of WPV. This report summarizes discussions that took place during the conference. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2006, 52 pp. AU - [Unknown] Y1 - 2006/09// PY - 2006 DA - September 2006 EP - 52p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Occupational health and safety KW - Workplace violence - Research KW - Workplace violence - Prevention KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58753145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=%5BUnknown%5D&rft.aulast=%5BUnknown%5D&rft.aufirst=&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=52p&rft.isbn=&rft.btitle=Workplace+Violence+Prevention+Strategies+and+Research+Needs&rft.title=Workplace+Violence+Prevention+Strategies+and+Research+Needs&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2006-144/pdfs/2006-144.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - DHHS (NIOSH) Publication No. 2006-144 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Ergonomics and Mining: Charting a Path to a Safer Workplace AN - 58751896; 2007-20605 AB - Ergonomics processes described in the literature have been associated mostly with manufacturing, financial, electronics, and office settings where working conditions tend to be rather constant and repetitive. The information presented in this document describes how Bridger Coal Company implemented an ergonomics process at its Jim Bridger Mine from 2001 through 2004. The process developed by the Ergonomics Committee, the promotion of the process to management and employees, and the impacts of the process on working conditions at the mine are reviewed. Barriers overcome and lessons learned are also described. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2006, 44 pp. AU - Gust, Paul AU - Johnson, Kean AU - Lewis, Pauline AU - Steiner, Lisa AU - Torma-Krajewski, Janet Y1 - 2006/09// PY - 2006 DA - September 2006 EP - 44p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Labor conditions and policy - Occupational health and safety KW - Mining industry - Safety measures KW - Human engineering - United States KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58751896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gust%2C+Paul%3BJohnson%2C+Kean%3BLewis%2C+Pauline%3BSteiner%2C+Lisa%3BTorma-Krajewski%2C+Janet&rft.aulast=Gust&rft.aufirst=Paul&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=44p&rft.isbn=&rft.btitle=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.title=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2006-141.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - NIOSH Publication No. 2006-141 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1 AN - 228355169; 16906159 AB - Receptor oligomerization is vital for activating intracellular signaling, in part by initiating events that recruit effector and adaptor proteins to sites of active signaling. Whether these distal molecules themselves oligomerize is not well appreciated. In this study, we examined the molecular interactions of the adaptor protein GRB2. In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL. Using biochemical and biophysical techniques in conjunction with confocal microscopy, we observed that the simultaneous association of GRB2, via its SH2 and SH3 domains, with multivalent ligands led to the oligomerization of these ligands, which affected signaling. These data suggest that multipoint binding of distal adaptor proteins mediates the formation of oligomeric signaling clusters vital for intracellular signaling. JF - Nature Structural & Molecular Biology AU - Houtman, Jon C D AU - Yamaguchi, Hiroshi AU - Barda-Saad, Mira AU - Braiman, Alex AU - Bowden, Brent AU - Appella, Ettore AU - Schuck, Peter AU - Samelson, Lawrence E Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 798 EP - 805 CY - New York PB - Nature Publishing Group VL - 13 IS - 9 SN - 15459993 KW - Biology KW - Adaptor Proteins, Signal Transducing KW - GRB2 Adaptor Protein KW - GRB2 protein, human KW - LAT protein, human KW - Ligands KW - Membrane Proteins KW - Phosphopeptides KW - Receptors, Antigen, T-Cell KW - SOS1 Protein KW - Proline KW - Molecular biology KW - Cellular biology KW - Signal transduction KW - Proteins KW - Binding sites KW - GRB2 Adaptor Protein -- chemistry KW - SOS1 Protein -- chemistry KW - Membrane Proteins -- chemistry KW - Humans KW - Receptors, Antigen, T-Cell -- metabolism KW - Jurkat Cells KW - Amino Acid Sequence KW - Models, Biological KW - Protein Binding KW - src Homology Domains KW - Adaptor Proteins, Signal Transducing -- chemistry KW - Phosphopeptides -- metabolism KW - Proline -- metabolism KW - Molecular Sequence Data KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Membrane Proteins -- metabolism KW - SOS1 Protein -- metabolism KW - Signal Transduction KW - Protein Structure, Quaternary KW - GRB2 Adaptor Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/228355169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=Oligomerization+of+signaling+complexes+by+the+multipoint+binding+of+GRB2+to+both+LAT+and+SOS1&rft.au=Houtman%2C+Jon+C+D%3BYamaguchi%2C+Hiroshi%3BBarda-Saad%2C+Mira%3BBraiman%2C+Alex%3BBowden%2C+Brent%3BAppella%2C+Ettore%3BSchuck%2C+Peter%3BSamelson%2C+Lawrence+E&rft.aulast=Houtman&rft.aufirst=Jon+C&rft.date=2006-09-01&rft.volume=13&rft.issue=9&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb1133 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Sep 2006 N1 - Last updated - 2014-04-29 DO - http://dx.doi.org/10.1038/nsmb1133 ER - TY - JOUR T1 - Toxicogenomics-A New Systems Toxicology Approach to Understanding of Gene-Environment Interactions AN - 20724169; 7220765 AB - Toxicogenomics is a new interdisciplinary area of research being developed to monitor the expression of multiple genes, proteins, and metabolites simultaneously. It combines new technologies in genomics, proteomics, and metabolomics with traditional tools of pathology and toxicology to study biological response to drugs and other environmental xenobiotics. The biological response to environmental exposure is so complex and involves so many interactive factors that the use of a systems biology analytical approach is required. In my opinion, the development of the field of toxicogenomics will provide powerful and relatively inexpensive tools to identify biomarkers and to relate exposure and biological events during disease progression. JF - Annals of the New York Academy of Sciences AU - Olden, Kenneth AD - Cell Adhesion and Metastasis Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, olden@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 703 EP - 706 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 IS - 1 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Genetics Abstracts KW - Metabolites KW - proteomics KW - Xenobiotics KW - genomics KW - Drugs KW - biomarkers KW - metabolomics KW - X 24300:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Toxicogenomics-A+New+Systems+Toxicology+Approach+to+Understanding+of+Gene-Environment+Interactions&rft.au=Olden%2C+Kenneth&rft.aulast=Olden&rft.aufirst=Kenneth&rft.date=2006-09-01&rft.volume=1076&rft.issue=1&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1371.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - References, 8. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metabolites; genomics; Xenobiotics; proteomics; biomarkers; Drugs; metabolomics DO - http://dx.doi.org/10.1196/annals.1371.026 ER - TY - JOUR T1 - Effect of Fluoridated Public Water Supplies on Dental Caries Prevalence AN - 20493202; 7791463 AB - As early as 1942, it had been adequately demonstrated that the use of fluoride-bearing drinking waters produces a marked reduction in the incidence of dental caries. It was also known by that time that this beneficial effect occurs in populations using water supplies containing fluoride from natural sources in concentrations below the level established as the threshold for mottled enamel or endemic fluorosis. JF - Bulletin of The World Health Organization AU - Arnold, FA Jr AU - Dean, H T AU - Jay, P AU - Knutson, J W AD - National Institute of Dental Research, National Institutes of Health, Public Health Service Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 761 VL - 84 IS - 9 SN - 0042-9686, 0042-9686 KW - Aqualine Abstracts KW - Drinking Water KW - Water Supply KW - Public Waters KW - Fluorides KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20493202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+The+World+Health+Organization&rft.atitle=Effect+of+Fluoridated+Public+Water+Supplies+on+Dental+Caries+Prevalence&rft.au=Arnold%2C+FA+Jr%3BDean%2C+H+T%3BJay%2C+P%3BKnutson%2C+J+W&rft.aulast=Arnold&rft.aufirst=FA&rft.date=2006-09-01&rft.volume=84&rft.issue=9&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+The+World+Health+Organization&rft.issn=00429686&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drinking Water; Water Supply; Public Waters; Fluorides ER - TY - JOUR T1 - Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering AN - 20295516; 7536776 AB - The feasibility of size exclusion chromotography (SEC)-multiangle laser-light scattering as a technique to investigate aggregation and degradation of glycosylated and nonglycosylated proteins, and antibodies under various conditions such as addition of detergent, changes in pH, and variation of protein concentration and heat stress temperature was examined. Separation of proteins and their aggregates was performed using SEC-high-performance liquid chromatography. Detection of analytes was carried out with on-line UV, refractive index, and multiangle laser light-scattering detectors. Quantification and molecular weight determination were performed using commercial software. Aggregation and degradation were examined under various conditions and quantitative results are presented for bovine serum albumin, choriogonadotropin, glyceraldehyde-3-phosphate dehydrogenase, Herceptin, and ReoPro. This method can simultaneously determine both the quantities and the molecular weights of macromolecules from a single injection. The determination of molecular weight is absolute which avoids misleading results caused by molecular shape or interactions with the column matrix. This technique is valuable not only for assessing the extent of aggregation but also for effectively monitoring molecule degradation as evidenced by molecular weight reduction and change in monomer amount. JF - Analytical Biochemistry AU - Ye, Hongping AD - Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA, yeh@cder.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 76 EP - 85 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 356 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - SEC-MALLS KW - Protein aggregation KW - Absolute molecular weight KW - Protein degradation KW - Pharmaceutical proteins KW - Glycoproteins KW - Temperature effects KW - Macromolecules KW - Detergents KW - Light scattering KW - Stress KW - Monomers KW - Computer programs KW - Glyceraldehyde-3-phosphate dehydrogenase KW - software KW - Antibodies KW - Bovine serum albumin KW - Liquid chromatography KW - Heat KW - Molecular weight KW - Lasers KW - pH effects KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20295516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Simultaneous+determination+of+protein+aggregation%2C+degradation%2C+and+absolute+molecular+weight+by+size+exclusion+chromatography-multiangle+laser+light+scattering&rft.au=Ye%2C+Hongping&rft.aulast=Ye&rft.aufirst=Hongping&rft.date=2006-09-01&rft.volume=356&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2006.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Macromolecules; Detergents; Light scattering; Stress; Monomers; Computer programs; Antibodies; software; Glyceraldehyde-3-phosphate dehydrogenase; Bovine serum albumin; Heat; Liquid chromatography; Molecular weight; Lasers; pH effects; Protein interaction DO - http://dx.doi.org/10.1016/j.ab.2006.05.025 ER - TY - JOUR T1 - Hazardous Anticancer Drugs in Health Care: Environmental Exposure Assessment AN - 20161852; 7191057 AB - Exposure of healthcare workers to anticancer drugs became problematic in the 1970s. Shortly thereafter, studies began documenting exposure of healthcare workers to these drugs. Investigations employing biological markers, such as urine mutagenicity, chromosomal aberrations, sister chromatid exchanges, and micronuclei, demonstrated associations between occupational exposures and elevated marker levels. Other analytical methods emerged to monitor workplaces where drugs were handled. These contemporary studies uncovered widespread contamination of drugs on work surfaces, trace amounts in air samples, and their presence in the urine of workers. Vials containing these drugs are often contaminated with the drug when they are shipped. Most workplace surfaces are contaminated with the drugs being prepared and used in that area. Other anticancer/hazardous drugs would most likely be used in these areas. The interior surfaces of biological safety cabinets and isolators, floors, countertops, carts, storage bins, waste containers, treatment areas, tabletops, chairs, linen, and other items are all potential sources of exposure to anticancer drugs. Patient body fluids contain the drugs and/or metabolites, often more biologically active than the parent compounds. An exposure assessment of areas where anticancer/hazardous drugs are handled must consider every potential source and route of exposure. Data from surface contamination and inhalation studies suggest that dermal exposure is the primary route of exposure. Assessment of exposure is the first step in providing a safe work environment for these workers. However, because of the many drugs to which they are exposed, any assessment can only be an estimation of the overall exposure. JF - Annals of the New York Academy of Sciences AU - Connor, Thomas H AD - NIOSH MS C-23, Cincinnati, Ohio 45226, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 615 EP - 623 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Containers KW - Contamination KW - Micronuclei KW - Metabolites KW - Medical personnel KW - Workers KW - Air sampling KW - Chromosome aberrations KW - Drugs KW - Body fluids KW - Occupational exposure KW - Mutagenicity KW - Data processing KW - Skin KW - Wastes KW - sister chromatids KW - biomarkers KW - Antitumor agents KW - Storage KW - Health care KW - Urine KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20161852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Hazardous+Anticancer+Drugs+in+Health+Care%3A+Environmental+Exposure+Assessment&rft.au=Connor%2C+Thomas+H&rft.aulast=Connor&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Mutagenicity; Skin; Data processing; Contamination; Micronuclei; Wastes; sister chromatids; Metabolites; Antitumor agents; biomarkers; Medical personnel; Workers; Urine; Drugs; Chromosome aberrations; Occupational exposure; Body fluids; Storage; Containers; Health care; Air sampling ER - TY - JOUR T1 - Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats AN - 19856498; 6969111 AB - Aristolochic acid (AA) is present in at least 65 different kinds of plants, many of which are used as herbal folk remedies. AA is considered one of the most potent plant carcinogens in humans and animals. It has been associated with the development of urothelial cancers in humans, and kidney and forestomach tumors in rats. In the present study, we used the Big Blue transgenic rat model to evaluate the mutagenicity of AA in kidney of rats and to define the mechanism of action for the tumor induction by AA. Groups of six male Big Blue transgenic rats were gavaged with 0, 0.1, 1.0 and 10.0 mg AA/kg body weight 5 times a week for 12 weeks, a treatment protocol that resulted in tumors in kidneys and other tissues. The animals were sacrificed 1 day after the final treatment and the kidneys were isolated for assays to determine the mutant frequencies (MFs) and types of mutations induced by AA in the transgenic cII gene. AA treatment resulted in a strong linear relationship between MF inductions and treatment dose (R super(2) = 0.998). The cII MFs were 29 +/- 6 x 10 super(-6), 78 +/- 21 x 10 super(-6), 242 +/- 104 x 10 super(-6) and 1319 +/- 360 x 10 super(-6) in the control, low, medium and high dose treatment groups, respectively (p - 0.001 for all pair wise comparisons among the four treatment groups). These MFs correlated strongly with tumor incidences induced by the different doses of AA (Mengs et al., 1982). Sequence analysis of the cII mutants revealed that there was a statistically significant difference between the mutational spectra in the AA- treated and control rats (p - 0.05). A:T --> T:A transversion was the predominant type of mutation in the AA-treated rats whereas G:C --> A:T transition was the main type of mutations in the control rats. These results suggest that AA induces kidney tumors in rats though a mutagenic mechanism of action. JF - Toxicology Letters AU - Chen, Ling AU - Mei, Nan AU - Yao, Lei AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA, tchen@nctr.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 250 EP - 256 PB - Elsevier Science Ireland Ltd., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 165 IS - 3 SN - 0378-4274, 0378-4274 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Aristolochic acid KW - Mutagenicity KW - Kidney KW - Herb KW - Mutational spectrum KW - Carcinogenesis KW - Statistical analysis KW - Animal models KW - Mutant frequency KW - Tumors KW - Carcinogens KW - urothelial cancer KW - Transversion KW - Transgenic animals KW - Body weight KW - Herbal medicines KW - Mutation KW - W 30950:Waste Treatment & Pollution Clean-up KW - G 07800:Plants and Algae KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Science+and+Biotechnology&rft.atitle=Occurrence+of+Vibrio+parahaemolyticus+in+Fishery+Products+from+the+Southwestern+Coast+of+Korea&rft.au=Yoon%2C+CY%3BKang%2C+K+J&rft.aulast=Yoon&rft.aufirst=CY&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Food+Science+and+Biotechnology&rft.issn=12267708&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Animal models; Statistical analysis; Mutant frequency; Carcinogens; Tumors; urothelial cancer; Transversion; Transgenic animals; Body weight; Aristolochic acid; Kidney; Herbal medicines; Mutation DO - http://dx.doi.org/10.1016/j.toxlet.2006.04.008 ER - TY - JOUR T1 - TRANSFUSION COMPLICATIONS: Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety AN - 19847086; 7103131 AB - BACKGROUND:Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS:A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS:Vaccinia viremia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viremia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION:The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low. JF - Transfusion AU - Srinivasan, Kumar AU - Akolkar, Pradip N AU - Taffs, Rolf E AU - Hewlett, Indira K AD - Kumar Srinivasan, PhD, HFM-315, FDA, CBER, DETTD, 1401 Rockville Pike, Rockville MD 20852-1448, kumar.srinivasan@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1589 EP - 1592 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 46 IS - 9 SN - 0041-1132, 0041-1132 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Blood donors KW - vaccines KW - Vero cells KW - bioterrorism KW - Disasters KW - Cell culture KW - clinical trials KW - Vaccination KW - Clinical trials KW - Smallpox KW - Peripheral blood mononuclear cells KW - Vaccinia virus KW - Blood transfusion KW - Viremia KW - Vaccines KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=TRANSFUSION+COMPLICATIONS%3A+Absence+of+detectable+viremia+in+plasma+and+peripheral+blood+mononuclear+cells+from+smallpox+vaccinees%3A+implications+for+blood+safety&rft.au=Srinivasan%2C+Kumar%3BAkolkar%2C+Pradip+N%3BTaffs%2C+Rolf+E%3BHewlett%2C+Indira+K&rft.aulast=Srinivasan&rft.aufirst=Kumar&rft.date=2006-09-01&rft.volume=46&rft.issue=9&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2006.04.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Tables, 2; references, 8. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smallpox; Blood donors; Peripheral blood mononuclear cells; Blood transfusion; Vero cells; bioterrorism; Cell culture; Vaccines; Viremia; Clinical trials; Vaccination; vaccines; Disasters; clinical trials; Vaccinia virus DO - http://dx.doi.org/10.1111/j.1537-2995.2006.00936.x ER - TY - JOUR T1 - Inactivation of Clostridium botulinum nonproteolytic type B spores by high pressure processing at moderate to elevated high temperatures AN - 19844254; 6989855 AB - The effect of high pressure and high temperature treatments at various process times on the inactivation of spores of Clostridium botulinum nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B, suspended in phosphate buffer (0.067 M, pH 7.0) and a crabmeat blend was investigated. Spores of KAP8-B were less resistant to high pressure treatment than the spores of 2-B, 17-B, and KAP9-B in both phosphate buffer and crabmeat blend. No survivors of initial counts (> 4.3 log units) of KAP8-B spores were detected in these menstura after processing at 827 MPa and 60 degree C for 10 min. The amount of inactivation of spores of 2-B, 17-B, and KAP9-B in phosphate buffer or crabmeat blend increased with the increase in processing time from 10 to 30 min at 827 MPa and 75 degree C. Similar inactivation patterns were observed for these spores in both phosphate buffer and crabmeat blend. A reduction of > 6-log units of 2-B, 17-B, and KAP9-B spores in phosphate buffer and crabmeat blend was observed at 827 MPa and 75 degree C for a processing time of between 20 and 30 min. Crabmeat blend as a suspension menstrum provided no protection against inactivation of spores of 2-B, 17-B, and KAP9-B by high pressure processing. High temperature (> 95 degree C) and lower pressure (620 MPa) treatments for up to 10 min were also found to inactivate 17-B spores in phosphate buffer. Spores of nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B in phosphate buffer and crabmeat blend can be inactivated by a combination of high pressure and temperature treatments. Industrial relevance Spores of nonproteolytic type B strains of Clostridium botulinum are of primary concern because they have been involved in the foodborne botulism outbreaks associated with marine products. Foodborne botulism results from consumption of these foods in which C. botulinum has grown and produced neurotoxin. Recently, high pressure processing (HPP) received a great deal of interest because of its ability to destroy vegetative pathogens, viruses, and certain bacterial spores and results in a product with natural sensory, quality, and nutritional attributes. Currently, HPP is being evaluated at the National Center for Food Safety and Technology as an alternative to other traditional thermal processes for its ability to inactivate C. botulinum spores. In this study, the effects of high pressure in conjunction with moderate to elevated high temperatures on inactivation of C. botulinum nonproteolytic type B spores were investigated. Based on limited number of strains tested, HPP showed a potential of destroying spores of nonproteolytic type B strains of C. botulinum when process temperature is above 75 degree C. JF - Innovative Food Science and Emerging Technologies AU - Reddy, N R AU - Tetzloff, R C AU - Solomon, H M AU - Larkin, J W AD - National Center for Food Safety and Technology, Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA, rukma.reddy@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 169 EP - 175 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 7 IS - 3 SN - 1466-8564, 1466-8564 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - High pressure processing KW - Inactivation KW - Clostridium botulinum KW - Spores KW - inactivation KW - buffers KW - Food KW - Viruses KW - Nutrition KW - Food consumption KW - Pressure KW - pH effects KW - pH KW - Temperature effects KW - Botulism KW - Temperature KW - outbreaks KW - Pathogens KW - Food contamination KW - Sensory properties KW - Phosphates KW - Phosphate KW - innovations KW - Neurotoxins KW - high temperature KW - Technology KW - V 22490:Miscellaneous KW - X 24370:Natural Toxins KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Innovative+Food+Science+and+Emerging+Technologies&rft.atitle=Inactivation+of+Clostridium+botulinum+nonproteolytic+type+B+spores+by+high+pressure+processing+at+moderate+to+elevated+high+temperatures&rft.au=Reddy%2C+N+R%3BTetzloff%2C+R+C%3BSolomon%2C+H+M%3BLarkin%2C+J+W&rft.aulast=Reddy&rft.aufirst=N&rft.date=2006-09-01&rft.volume=7&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Innovative+Food+Science+and+Emerging+Technologies&rft.issn=14668564&rft_id=info:doi/10.1016%2Fj.ifset.2006.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sensory properties; Temperature effects; Food consumption; Phosphate; Botulism; Food; Pathogens; Neurotoxins; Pressure; Spores; pH effects; inactivation; buffers; Viruses; Temperature; outbreaks; Food contamination; Nutrition; Phosphates; innovations; pH; high temperature; Technology; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.ifset.2006.03.002 ER - TY - RPRT T1 - Ergonomics and Mining: Charting a Path to a Safer Workplace AN - 19638144; 7371898 AB - Ergonomics processes described in the literature have been associated mostly with manufacturing, financial, electronics, and office settings where working conditions tend to be rather constant and repetitive. The information presented in this document demonstrates, however, that an ergonomics process can also be implemented in a setting such as mining where working conditions frequently change and workers are periodically exposed to extreme weather conditions. This document describes how Bridger Coal Company implemented an ergonomics process at its Jim Bridger Mine from 2001 through 2004. The process developed by the Ergonomics Committee, the promotion of the process to management and employees, and the impacts of the process on working conditions at the mine are reviewed. Barriers overcome and lessons learned are also described. Quotes from Bridger Coal Company employees are included in the document to add a personal perspective. Other industries with working conditions similar to mining, such as construction and agriculture, may find this information useful. JF - Ergonomics and mining: charting a path to a safer workplace. [np]. Sep 2006. AU - Torma-Krajewski, J AU - Steiner, L AU - Lewis, P AU - Gust, P AU - Johnson, K Y1 - 2006/09// PY - 2006 DA - Sep 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - NIOSH 2006-104 KW - Weather KW - Reviews KW - agriculture KW - committees KW - Coal KW - Mines KW - Ergonomics KW - working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19638144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Torma-Krajewski%2C+J%3BSteiner%2C+L%3BLewis%2C+P%3BGust%2C+P%3BJohnson%2C+K&rft.aulast=Torma-Krajewski&rft.aufirst=J&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.title=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 ER - TY - JOUR T1 - Impact of microarray data quality on genomic data submissions to the FDA AN - 19613933; 7333120 AB - How can microarray data best be exploited and integrated into the regulatory decision-making process? JF - Nature Biotechnology AU - Frueh, F W AD - US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluationand Research, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA, felix.frueh@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1105 EP - 1107 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Decision making KW - Data processing KW - genomics KW - DNA microarrays KW - W 30900:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Impact+of+microarray+data+quality+on+genomic+data+submissions+to+the+FDA&rft.au=Frueh%2C+F+W&rft.aulast=Frueh&rft.aufirst=F&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0906-1105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Decision making; Data processing; genomics; DNA microarrays DO - http://dx.doi.org/10.1038/nbt0906-1105 ER - TY - JOUR T1 - Apoptosis and Bax Expression are Increased by Coal Dust in the Polycyclic Aromatic Hydrocarbon-Exposed Lung AN - 19546992; 7263161 AB - BACKGROUND: Miners inhaling respirable coal dust (CD) frequently develop coal workers' pneumoconiosis, a dust-associated pneumoconiosis characterized by lung inflammation and variable fibrosis. Many coal miners are also exposed to polycyclic aromatic hydrocarbon (PAH) components of diesel engine exhaust and cigarette smoke, which may contribute to lung disease in these workers. Recently, apoptosis was reported to play a critical role in the development of another pneumoconiosis of miners, silicosis. In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs. METHODS: We investigated the hypothesis that apoptosis plays a critical role in lung injury and down-regulation of CYP1A1 induction in mixed exposures to CD and PAHs. We exposed rats intratracheally to 0.0, 2.5, 10.0, 20.0, or 40.0 mg/rat CD and, 11 days later, to intraperitoneal beta -naphthoflavone (BNF), a PAH. In another group of rats exposed to CD and BNF, caspase activity was inhibited by injection of the pan-caspase inhibitor Q-VD-OPH [quinoline-Val-Asp (OMe)-CH sub(2)-OPH]. RESULTS: In rats exposed to BNF, CD exposure increased alveolar expression of the proapoptotic mediator Bax but decreased CYP1A1 induction relative to BNF exposure alone. Pan-caspase inhibition decreased CD-associated Bax expression and apoptosis but did not restore CYP1A1 activity. Further, CD-induced lung inflammation and alveolar epithelial cell hypertrophy and hyperplasia were not suppressed by caspase inhibition. CONCLUSIONS: Combined BNF and CD exposure increased Bax expression and apoptosis in the lung, but Bax and apoptosis were not the major determinants of early lung injury in this model. JF - Environmental Health Perspectives AU - Ghanem, M M AU - Battelli, LA AU - Mercer, R R AU - Scabilloni, J F AU - Kashon, M L AU - Ma, JYC AU - Nath, J AU - Hubbs, A F AD - Pathology and Physiology Research Branch, Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505 USA, Ahubbs@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1367 EP - 1373 VL - 114 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Inhalation KW - Epithelial cells KW - Apoptosis KW - Injuries KW - Fibrosis KW - Pneumoconiosis KW - Animal models KW - Cigarette smoke KW - Coal KW - Dust KW - Silicosis KW - Occupational exposure KW - Polycyclic aromatic hydrocarbons KW - Lung diseases KW - Alveoli KW - Inflammation KW - Exhausts KW - Smoke KW - Hyperplasia KW - Hypertrophy KW - Cytochrome KW - beta -Naphthoflavone KW - Lung KW - Bax protein KW - Diesel KW - Caspase KW - Coal dust KW - Mining KW - Cytochrome P450 KW - Diesel engines KW - Aromatics KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19546992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Apoptosis+and+Bax+Expression+are+Increased+by+Coal+Dust+in+the+Polycyclic+Aromatic+Hydrocarbon-Exposed+Lung&rft.au=Ghanem%2C+M+M%3BBattelli%2C+LA%3BMercer%2C+R+R%3BScabilloni%2C+J+F%3BKashon%2C+M+L%3BMa%2C+JYC%3BNath%2C+J%3BHubbs%2C+A+F&rft.aulast=Ghanem&rft.aufirst=M&rft.date=2006-09-01&rft.volume=114&rft.issue=9&rft.spage=1367&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8906 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Polycyclic aromatic hydrocarbons; Apoptosis; Fibrosis; Lung diseases; Animal models; Pneumoconiosis; Cigarette smoke; Coal; Alveoli; Exhausts; Inflammation; Hypertrophy; Hyperplasia; beta -Naphthoflavone; Silicosis; Bax protein; Coal dust; Caspase; Diesel; Cytochrome P450; Aromatics; Occupational exposure; Inhalation; Injuries; Dust; Smoke; Cytochrome; Lung; Mining; Diesel engines DO - http://dx.doi.org/10.1289/ehp.8906 ER - TY - JOUR T1 - Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids AN - 19545383; 7259769 AB - We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report that DHP-derived DNA adducts are formed in the liver of female F344 rats, gavaged with three dietary supplements (comfrey root extract, comfrey compound oil, and coltsfoot root extract), or an extract of a Chinese herbal plant, flos farfara (Kuan Tong Hua). JF - Toxicology and Industrial Health AU - Chou, M W AU - Fu, P P AD - Division of Biochemical Toxicology, HFT-140, National Center for Toxicological Research, Jefferson, AR 72079, USA, mchou@nctr.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 321 EP - 327 VL - 22 IS - 8 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - pyrrolizidine alkaloids KW - Oil KW - DNA adducts KW - Dietary supplements KW - Herbal medicines KW - Liver KW - Tumorigenicity KW - Plant extracts KW - biomarkers KW - Metabolism KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19545383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Formation+of+DHP-derived+DNA+adducts+in+vivo+from+dietary+supplements+and+Chinese+herbal+plant+extracts+containing+carcinogenic+pyrrolizidine+alkaloids&rft.au=Chou%2C+M+W%3BFu%2C+P+P&rft.aulast=Chou&rft.aufirst=M&rft.date=2006-09-01&rft.volume=22&rft.issue=8&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233706071765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oil; pyrrolizidine alkaloids; DNA adducts; Dietary supplements; Liver; Herbal medicines; Tumorigenicity; Plant extracts; biomarkers; Metabolism DO - http://dx.doi.org/10.1177/0748233706071765 ER - TY - JOUR T1 - Potential Health Effects of Occupational Chlorinated Solvent Exposure AN - 19507027; 7191021 AB - Based on toxicology, metabolism, animal studies, and human studies, occupational exposure to chlorinated aliphatic solvents (methanes, ethanes, and ethenes) has been associated with numerous adverse health effects, including central nervous system, reproductive, liver, and kidney toxicity, and carcinogenicity. However, many of these solvents remain in active, large-volume use. This article reviews the recent occupational epidemiology literature on the most widely used solvents, methylene chloride, chloroform, trichloroethylene, and tetrachloroethylene, and discusses other chlorinated aliphatics. The impact of studies to date has been lessened because of small study size, inability to control for confounding factors, particularly smoking and mixed occupational exposures, and the lack of evidence for a solid pathway from occupational exposure to biological evidence of exposure, to precursors of health effects, and to health effects. International differences in exposure limits may provide a "natural experiment" in the coming years if countries that have lowered exposure limits subsequently experience decreased adverse health effects among exposed workers. Such decreases could provide some evidence that higher levels of adverse health effects were associated with higher levels of solvent exposure. The definitive studies, which should be prospective biomarker studies incorporating body burden of solvents as well as markers of effect, remain to be done. JF - Annals of the New York Academy of Sciences AU - Ruder, Avima M AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 207 EP - 227 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - ethene KW - Chlorides KW - Chloroform KW - Smoking KW - Carcinogenicity KW - Trichloroethylene KW - Occupational exposure KW - Bioindicators KW - Methane KW - Solvents KW - Toxicity KW - biomarkers KW - Epidemiology KW - Reviews KW - Kidney KW - Liver KW - Tetrachloroethylene KW - Metabolism KW - Methylene chloride KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19507027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Potential+Health+Effects+of+Occupational+Chlorinated+Solvent+Exposure&rft.au=Ruder%2C+Avima+M&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Methane; ethene; Solvents; Toxicity; biomarkers; Smoking; Chloroform; Epidemiology; Carcinogenicity; Reviews; Liver; Kidney; Trichloroethylene; Tetrachloroethylene; Methylene chloride; Metabolism; Occupational exposure; Bioindicators; Chlorides ER - TY - JOUR T1 - Comparison of Performance of Three Different Types of Respiratory Protection Devices AN - 19392263; 7152827 AB - Respiratory protection is offered to American workers in a variety of ways to guard against potential inhalation hazards. Two of the most common ways are elastomeric N95 respirators and N95 filtering-facepiece respirators. Some in the health care industry feel that surgical masks provide an acceptable level of protection in certain situations against particular hazards. This study compared the performance of these types of respiratory protection during a simulated workplace test that measured both filter penetration and face-seal leakage. A panel of 25 test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020, and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. The results of these tests produced a simulated workplace protection factor (SWPF). The geometric mean (GM) and the 5th percentile values of the SWPFs were computed by category of respiratory protection using the six overall SWPF values. The level of protection provided by each of the three respiratory protection types was compared. The GM and 5th percentile SWPF values without fit testing were used for the comparison, as surgical masks were not intended to be fit tested. The GM values were 36 for elastomeric N95 respirators, 21 for N95 filtering-facepiece respirators, and 3 for surgical masks. An analysis of variance demonstrated a statistically significant difference between all three. Elastomeric N95 respirators had the highest 5th percentile SWPF of 7. N95 filtering-facepiece respirators and surgical masks had 5th percentile SWPFs of 3 and 1, respectively. A Fisher Exact Test revealed that the 5th percentile SWPFs for all three types of respiratory protection were statistically different. In addition, both qualitative (Bitrex and saccharin) and quantitative (N95-Companion)fit testing were performed on the N95 filtering- and elastomeric-facepiece respirators. It was found that passing a fit test generally improves the protection afforded the wearer. Passing the Bitrex fit test resulted in 5th percentile SWPFs of 11.1 and 7.9 for elastomeric and filtering-facepiece respirators, respectively. After passing the saccharin tests, the elastomeric respirators provided a 5th percentile of 11.7, and the filtering-facepiece respirators provided a 5th percentile of 11.0. The 5th percentiles after passing the N95-Companion were 13.0 for the elastomeric respirators and 20.5 for the filtering-facepiece respirators. The data supports fit testing as an essential element of a complete respiratory protection program. JF - Journal of Occupational and Environmental Hygiene AU - Lawrence, R B AU - Duling, M G AU - Calvert, CA AU - Coffey, C C AD - NIOSH, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, rbl2@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 465 EP - 474 VL - 3 IS - 9 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Filters KW - Leakage KW - Performance KW - Respirators KW - Hygiene KW - Protective equipment KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+Cashew+Nut+DNA+in+Spiked+Baked+Goods+Using+a+Real-Time+Polymerase+Chain+Reaction+Method&rft.au=Brzezinski%2C+J+L&rft.aulast=Brzezinski&rft.aufirst=J&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Filters; Inhalation; Leakage; Performance; Hygiene; Respirators; Protective equipment; Occupational exposure DO - http://dx.doi.org/10.1080/15459620600829211 ER - TY - JOUR T1 - Mycobacterium tuberculosis Delta RD1 Delta panCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis AN - 19338132; 7079555 AB - The global epidemic of tuberculosis (TB), fueled by the growing HIV pandemic, warrants the development of a safe and effective vaccine against TB. We report the construction and characterization of an unlinked double deletion mutant of Mycobacterium tuberculosis H37Rv that deletes both the primary attenuating mutation of BCG ( Delta RD1) and two genes required for the synthesis of pantothenate ( Delta panCD). The M. tuberculosis Delta RD1 Delta panCD (mc super(2)6030) mutant undergoes limited replication in mice, and yet is both significantly safer than BCG in immunocompromised mice and also safe in guinea pigs. Additionally, the mc super(2)6030 strain does not reactivate in a mouse chemo- immunosuppression model. Importantly, long-lived protective immune responses following immunization with the mc super(2)6030 strain prolong the survival of wild type mice, and CD4-deficient mice against an aerosol challenge with virulent M. tuberculosis. Given its overall safety and effectiveness, the mc super(2)6030 live attenuated strain should be considered as a human vaccine candidate for protecting both healthy and HIV-infected individuals against TB. JF - Vaccine AU - Sambandamurthy, Vasan K AU - Derrick, Steven C AU - Hsu, Tsungda AU - Chen, Bing AU - Larsen, Michelle H AU - Jalapathy, Kripa V AU - Chen, Mei AU - Kim, John AU - Porcelli, Steven A AU - Chan, John AU - Morris, Sheldon L AU - Jacobs, William R AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States, jacobsw@hhmi.org Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 6309 EP - 6320 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 24 IS - 37-39 SN - 0264-410X, 0264-410X KW - HIV KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Tuberculosis KW - Mycobacterial vaccines KW - BCG KW - Attenuated strains KW - Aerosols KW - Deletion mutant KW - Epidemics KW - Replication KW - Animal models KW - Survival KW - Immunization KW - pandemics KW - CD4 antigen KW - Human immunodeficiency virus KW - Vaccines KW - Mutation KW - Mycobacterium tuberculosis KW - Immunosuppression KW - J 02310:Genetics & Taxonomy KW - F 06905:Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Mycobacterium+tuberculosis+Delta+RD1+Delta+panCD%3A+A+safe+and+limited+replicating+mutant+strain+that+protects+immunocompetent+and+immunocompromised+mice+against+experimental+tuberculosis&rft.au=Sambandamurthy%2C+Vasan+K%3BDerrick%2C+Steven+C%3BHsu%2C+Tsungda%3BChen%2C+Bing%3BLarsen%2C+Michelle+H%3BJalapathy%2C+Kripa+V%3BChen%2C+Mei%3BKim%2C+John%3BPorcelli%2C+Steven+A%3BChan%2C+John%3BMorris%2C+Sheldon+L%3BJacobs%2C+William+R&rft.aulast=Sambandamurthy&rft.aufirst=Vasan&rft.date=2006-09-01&rft.volume=24&rft.issue=37-39&rft.spage=6309&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Aerosols; Epidemics; Deletion mutant; Replication; Animal models; Survival; Immunization; CD4 antigen; pandemics; BCG; Tuberculosis; Vaccines; Mutation; Immunosuppression; Human immunodeficiency virus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2006.05.097 ER - TY - JOUR T1 - Maternal infection and white matter toxicity AN - 19326631; 7074634 AB - Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology. JF - Neurotoxicology AU - Harry, GJean AU - Lawler, Cindy AU - Brunssen, Susan H AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA, harry@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 658 EP - 670 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Microglia KW - White matter damage KW - Inflammation KW - Oligodendrocyte KW - Immune status KW - Neurological diseases KW - Oligodendrocytes KW - Risk factors KW - Disseminated infection KW - Substantia alba KW - Progeny KW - Toxicity KW - Pregnancy KW - Infants KW - N3 11028:Neuropharmacology & toxicology KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19326631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Maternal+infection+and+white+matter+toxicity&rft.au=Harry%2C+GJean%3BLawler%2C+Cindy%3BBrunssen%2C+Susan+H&rft.aulast=Harry&rft.aufirst=GJean&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2006.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immune status; Neurological diseases; Oligodendrocytes; Risk factors; Disseminated infection; Substantia alba; Progeny; Toxicity; Infants; Inflammation; Pregnancy DO - http://dx.doi.org/10.1016/j.neuro.2006.05.004 ER - TY - JOUR T1 - Separate Pathways for O Acetylation of Polymeric and Monomeric Sialic Acids and Identification of Sialyl O-Acetyl Esterase in Escherichia coli K1 AN - 19325474; 7061479 AB - O acetylation at carbon positions 7 or 9 of the sialic acid residues in the polysialic acid capsule of Escherichia coli K1 is catalyzed by a phase-variable contingency locus, neuO, carried by the K1-specific prophage, CUS-3. Here we describe a novel method for analyzing polymeric sialic acid O acetylation that involves the release of surface sialic acids by endo-N-acetylneuraminidase digestion, followed by fluorescent labeling and detection of quinoxalinone derivatives by chromatography. The results indicated that NeuO is responsible for the majority of capsule modification that takes place in vivo. However, a minor neuO-independent O acetylation pathway was detected that is dependent on the bifunctional polypeptide encoded by neuD. This pathway involves O acetylation of monomeric sialic acid and is regulated by another bifunctional enzyme, NeuA, which includes N-terminal synthetase and C-terminal sialyl O-esterase domains. A homologue of the NeuA C-terminal domain (Pm1710) in Pasteurella multocida was also shown to be an esterase, suggesting that it functions in the catabolism of acetylated environmental sialic acids. Our combined results indicate a previously unexpected complexity in the synthesis and catabolism of microbial sialic and polysialic acids. These findings are key to understanding the biological functions of modified sialic acids in E. coli K1 and other species and may provide new targets for drug or vaccine development. JF - Journal of Bacteriology AU - Steenbergen, Susan M AU - Lee, Young-Choon AU - Vann, Willie F AU - Vionnet, Justine AU - Wright, Lori F AU - Vimr, Eric R AD - Laboratory of Sialobiology and Comparative Metabolomics, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois. Department of Biotechnology, Dong-A University, Busan, South Korea. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland. Department of Microbiology and Immunology, University of Rochester, Rochester, New York Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 6195 EP - 6206 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 17 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Chromatography KW - esterase KW - Bifunctional enzymes KW - Pasteurella multocida KW - Drug development KW - Prophages KW - Digestion KW - Acetylation KW - Carbon KW - Escherichia coli KW - polysialic acid KW - Vaccines KW - Sialic acids KW - Contingency KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19325474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Separate+Pathways+for+O+Acetylation+of+Polymeric+and+Monomeric+Sialic+Acids+and+Identification+of+Sialyl+O-Acetyl+Esterase+in+Escherichia+coli+K1&rft.au=Steenbergen%2C+Susan+M%3BLee%2C+Young-Choon%3BVann%2C+Willie+F%3BVionnet%2C+Justine%3BWright%2C+Lori+F%3BVimr%2C+Eric+R&rft.aulast=Steenbergen&rft.aufirst=Susan&rft.date=2006-09-01&rft.volume=188&rft.issue=17&rft.spage=6195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Digestion; Acetylation; Carbon; Chromatography; esterase; Bifunctional enzymes; Drug development; Vaccines; polysialic acid; Prophages; Contingency; Sialic acids; Escherichia coli; Pasteurella multocida ER - TY - JOUR T1 - Quinupristin-Dalfopristin Resistance in Enterococcus faecium Isolates from Humans, Farm Animals, and Grocery Store Meat in the United States AN - 19324597; 7062396 AB - Three hundred sixty-one quinupristin-dalfopristin (Q-D)-resistant Enterococcus faecium (QDREF) isolates were isolated from humans, turkeys, chickens, swine, dairy and beef cattle from farms, chicken carcasses, and ground pork from grocery stores in the United States from 1995 to 2003. These isolates were evaluated by pulsed-field gel electrophoresis (PFGE) to determine possible commonality between QDREF isolates from human and animal sources. PCR was performed to detect the streptogramin resistance genes vatD, vatE, and vgbA and the macrolide resistance gene ermB to determine the genetic mechanism of resistance in these isolates. QDREF from humans did not have PFGE patterns similar to those from animal sources. vatE was found in 35%, 26%, and 2% of QDREF isolates from turkeys, chickens, and humans, respectively, and was not found in QDREF isolates from other sources. ermB was commonly found in QDREF isolates from all sources. Known streptogramin resistance genes were absent in the majority of isolates, suggesting the presence of other, as-yet-undetermined, mechanisms of Q-D resistance. JF - Journal of Clinical Microbiology AU - Donabedian, S M AU - Perri, M B AU - Vager, D AU - Hershberger, E AU - Malani, P AU - Simjee, S AU - Chow, J AU - Vergis, EN AU - Muder, R R AU - Gay, K AU - Angulo, F J AU - Bartlett, P AU - Zervos, MJ AD - Henry Ford Hospital, Detroit, Michigan. University of Michigan Medical Center, Ann Arbor, Michigan. Food and Drug Administration, Centers for Veterinary Medicine, Rockville, Maryland. Wayne State University, Detroit, Michigan. Veterans Affairs Medical Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Centers for Disease Control and Prevention, Emerging Infections Program, Atlanta, Georgia. Michigan State University College of Veterinary Medicine, Lansing, Michigan Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3361 EP - 3365 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Farms KW - Streptogramins KW - quinupristin-dalfopristin KW - Pork KW - Enterococcus faecium KW - Meat KW - USA KW - Dairies KW - Carcasses KW - Beef KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19324597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Quinupristin-Dalfopristin+Resistance+in+Enterococcus+faecium+Isolates+from+Humans%2C+Farm+Animals%2C+and+Grocery+Store+Meat+in+the+United+States&rft.au=Donabedian%2C+S+M%3BPerri%2C+M+B%3BVager%2C+D%3BHershberger%2C+E%3BMalani%2C+P%3BSimjee%2C+S%3BChow%2C+J%3BVergis%2C+EN%3BMuder%2C+R+R%3BGay%2C+K%3BAngulo%2C+F+J%3BBartlett%2C+P%3BZervos%2C+MJ&rft.aulast=Donabedian&rft.aufirst=S&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=3361&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Meat; Dairies; Carcasses; Farms; Beef; Streptogramins; quinupristin-dalfopristin; Pork; Pulsed-field gel electrophoresis; Polymerase chain reaction; Enterococcus faecium; USA ER - TY - JOUR T1 - Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209) AN - 19322736; 7062798 AB - Our recent studies have shown that the dendritic cell-specific ICAM nonintegrin CD209 (DC-SIGN) specifically binds to the core LPS of Escherichia coli K12 (E. coli), promoting bacterial adherence and phagocytosis. In this current study, we attempted to map the sites within the core LPS that are directly involved in LPS-DC-SIGN interaction. We took advantage of four sets of well-defined core LPS mutants, which are derived from E. coli, Salmonella enterica serovar Typhimurium, Neisseria gonorrhoeae, and Haemophilus ducreyi and determined interaction of each of these four sets with DC-SIGN. Our results demonstrated that N-acetylglucosamine (GlcNAc) sugar residues within the core LPS in these bacteria play an essential role in targeting the DC-SIGN receptor. Our results also imply that DC-SIGN is an innate immune receptor and the interaction of bacterial core LPS and DC-SIGN may represent a primeval interaction between Gram-negative bacteria and host phagocytic cells. JF - Journal of Immunology AU - Zhang, Pei AU - Snyder, Scott AU - Feng, Peter AU - Azadi, Parastoo AU - Zhang, Shusheng AU - Bulgheresi, Silvia AU - Sanderson, Kenneth E AU - He, Johnny AU - Klena, John AU - Chen, Tie AD - Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Rockford, IL 61107. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602. Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, MD 20740. Faculty of Life Sciences, Department of Marine Biology, University of Vienna, Vienna, Austria. Salmonella Genetic Stock Centre, Department of Biological Sciences, Alberta, Canada. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202. School of Biological Sciences, University of Canterbury, Christchurch, New Zealand Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 4002 EP - 4011 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Sugar KW - N-Acetylglucosamine KW - Neisseria gonorrhoeae KW - Cores KW - DC-SIGN protein KW - Phagocytes KW - Salmonella enterica KW - Gram-negative bacteria KW - Escherichia coli KW - Lipopolysaccharides KW - Phagocytosis KW - Haemophilus ducreyi KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19322736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Role+of+N-Acetylglucosamine+within+Core+Lipopolysaccharide+of+Several+Species+of+Gram-Negative+Bacteria+in+Targeting+the+DC-SIGN+%28CD209%29&rft.au=Zhang%2C+Pei%3BSnyder%2C+Scott%3BFeng%2C+Peter%3BAzadi%2C+Parastoo%3BZhang%2C+Shusheng%3BBulgheresi%2C+Silvia%3BSanderson%2C+Kenneth+E%3BHe%2C+Johnny%3BKlena%2C+John%3BChen%2C+Tie&rft.aulast=Zhang&rft.aufirst=Pei&rft.date=2006-09-01&rft.volume=177&rft.issue=6&rft.spage=4002&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sugar; Cores; Phagocytes; DC-SIGN protein; Gram-negative bacteria; Lipopolysaccharides; N-Acetylglucosamine; Phagocytosis; Salmonella enterica; Escherichia coli; Neisseria gonorrhoeae; Haemophilus ducreyi ER - TY - JOUR T1 - The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements AN - 19319430; 7046484 AB - Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings. JF - Nature Biotechnology AU - Reid, Laura H AU - Jones, Wendell D AU - Shippy, Richard AU - Warrington, Janet A AU - Baker, Shawn C AU - Collins, Patrick J AU - De Longueville, Francoise AU - Kawasaki, Ernest S AU - Lee, Kathleen Y AU - Luo, Yuling AU - Sun, Yongming Andrew AU - Willey, James C AU - Setterquist, Robert A AU - Fischer, Gavin M AU - Tong, Weida AU - Dragan, Yvonne P AU - Dix, David J AU - Frueh, Felix W AU - Goodsaid, Federico M AU - Herman, Damir AU - Jensen, Roderick V AU - Johnson, Charles D AU - Lobenhofer, Edward K AU - Puri, Raj K AU - Scherf, Uwe AU - Thierry-Mieg, Jean AU - Wang, Charles AU - Wilson, Mike AU - Wolber, Paul K AU - Zhang, Lu AU - Amur, Shashi AU - Bao, Wenjun AU - Barbacioru, Catalin C AU - Lucas, Anne Bergstrom AU - Bertholet, Vincent AU - Boysen, Cecilie AU - Bromley, Bud AU - Brown, Donna AU - Brunner, Alan AU - Canales, Roger AU - Cao, Xiaoxi Megan AU - Cebula, Thomas A AU - Chen, James J AU - Cheng, Jing AU - Chu, Tzu-Ming AU - Chudin, Eugene AU - Corson, John AU - Corton, J Christopher AU - Croner, Lisa J AU - Davies, Christopher AU - Davison, Timothy S AU - Delenstarr, Glenda AU - Deng, Xutao AU - Dorris, David AU - Eklund, Aron C AU - Fan, Xiao-Hui AU - Fang, Hong AU - Fulmer-Smentek, Stephanie AU - Fuscoe, James C AU - Gallagher, Kathryn AU - Ge, Weigong AU - Guo, Lei AU - Guo, Xu AU - Hager, Janet AU - Haje, Paul K AU - Han, Jing AU - Han, Tao AU - Harbottle, Heather C AU - Harris, Stephen C AU - Hatchwell, Eli AU - Hauser, Craig A AU - Hester, Susan AU - Hong, Huixiao AU - Hurban, Patrick AU - Jackson, Scott A AU - Ji, Hanlee AU - Knight, Charles R AU - Kuo, Winston P AU - LeClerc, J Eugene AU - Levy, Shawn AU - Li, Quan-Zhen AU - Liu, Chunmei AU - Liu, Ying AU - Lombardi, Michael J AU - Ma, Yunqing AU - Magnuson, Scott R AU - Maqsodi, Botoul AU - McDaniel, Tim AU - Mei, Nan AU - Myklebost, Ola AU - Ning, Baitang AU - Novoradovskaya, Natalia AU - Orr, Michael S AU - Osborn, Terry W AU - Papallo, Adam AU - Patterson, Tucker A AU - Perkins, Roger G AU - Peters, Elizabeth H AU - Peterson, Ron AU - Philips, Kenneth L AU - Pine, P Scott AU - Pusztai, Lajos AU - Qian, Feng AU - Ren, Hongzu AU - Rosen, Mitch AU - Rosenzweig, Barry A AU - Samaha, Raymond R AU - Schena, Mark AU - Schroth, Gary P AU - Shchegrova, Svetlana AU - Smith, Dave D AU - Staedtler, Frank AU - Su, Zhenqiang AU - Sun, Hongmei AU - Szallasi, Zoltan AU - Tezak, Zivana AU - Thierry-Mieg, Danielle AU - Thompson, Karol L AU - Tikhonova, Irina AU - Turpaz, Yaron AU - Vallanat, Beena AU - Van, Christophe AU - Walker, Stephen J AU - Wang, Sue Jane AU - Wang, Yonghong AU - Wolfinger, Russ AU - Wong, Alex AU - Wu, Jie AU - Xiao, Chunlin AU - Xie, Qian AU - Xu, Jun AU - Yang, Wen AU - Zhang, Liang AU - Zhong, Sheng AU - Zong, Yaping AU - Slikker, William AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA., leming.shi@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1151 EP - 1161 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Quality control KW - DNA probes KW - Titration KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19319430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=The+MicroArray+Quality+Control+%28MAQC%29+project+shows+inter-+and+intraplatform+reproducibility+of+gene+expression+measurements&rft.au=Reid%2C+Laura+H%3BJones%2C+Wendell+D%3BShippy%2C+Richard%3BWarrington%2C+Janet+A%3BBaker%2C+Shawn+C%3BCollins%2C+Patrick+J%3BDe+Longueville%2C+Francoise%3BKawasaki%2C+Ernest+S%3BLee%2C+Kathleen+Y%3BLuo%2C+Yuling%3BSun%2C+Yongming+Andrew%3BWilley%2C+James+C%3BSetterquist%2C+Robert+A%3BFischer%2C+Gavin+M%3BTong%2C+Weida%3BDragan%2C+Yvonne+P%3BDix%2C+David+J%3BFrueh%2C+Felix+W%3BGoodsaid%2C+Federico+M%3BHerman%2C+Damir%3BJensen%2C+Roderick+V%3BJohnson%2C+Charles+D%3BLobenhofer%2C+Edward+K%3BPuri%2C+Raj+K%3BScherf%2C+Uwe%3BThierry-Mieg%2C+Jean%3BWang%2C+Charles%3BWilson%2C+Mike%3BWolber%2C+Paul+K%3BZhang%2C+Lu%3BAmur%2C+Shashi%3BBao%2C+Wenjun%3BBarbacioru%2C+Catalin+C%3BLucas%2C+Anne+Bergstrom%3BBertholet%2C+Vincent%3BBoysen%2C+Cecilie%3BBromley%2C+Bud%3BBrown%2C+Donna%3BBrunner%2C+Alan%3BCanales%2C+Roger%3BCao%2C+Xiaoxi+Megan%3BCebula%2C+Thomas+A%3BChen%2C+James+J%3BCheng%2C+Jing%3BChu%2C+Tzu-Ming%3BChudin%2C+Eugene%3BCorson%2C+John%3BCorton%2C+J+Christopher%3BCroner%2C+Lisa+J%3BDavies%2C+Christopher%3BDavison%2C+Timothy+S%3BDelenstarr%2C+Glenda%3BDeng%2C+Xutao%3BDorris%2C+David%3BEklund%2C+Aron+C%3BFan%2C+Xiao-Hui%3BFang%2C+Hong%3BFulmer-Smentek%2C+Stephanie%3BFuscoe%2C+James+C%3BGallagher%2C+Kathryn%3BGe%2C+Weigong%3BGuo%2C+Lei%3BGuo%2C+Xu%3BHager%2C+Janet%3BHaje%2C+Paul+K%3BHan%2C+Jing%3BHan%2C+Tao%3BHarbottle%2C+Heather+C%3BHarris%2C+Stephen+C%3BHatchwell%2C+Eli%3BHauser%2C+Craig+A%3BHester%2C+Susan%3BHong%2C+Huixiao%3BHurban%2C+Patrick%3BJackson%2C+Scott+A%3BJi%2C+Hanlee%3BKnight%2C+Charles+R%3BKuo%2C+Winston+P%3BLeClerc%2C+J+Eugene%3BLevy%2C+Shawn%3BLi%2C+Quan-Zhen%3BLiu%2C+Chunmei%3BLiu%2C+Ying%3BLombardi%2C+Michael+J%3BMa%2C+Yunqing%3BMagnuson%2C+Scott+R%3BMaqsodi%2C+Botoul%3BMcDaniel%2C+Tim%3BMei%2C+Nan%3BMyklebost%2C+Ola%3BNing%2C+Baitang%3BNovoradovskaya%2C+Natalia%3BOrr%2C+Michael+S%3BOsborn%2C+Terry+W%3BPapallo%2C+Adam%3BPatterson%2C+Tucker+A%3BPerkins%2C+Roger+G%3BPeters%2C+Elizabeth+H%3BPeterson%2C+Ron%3BPhilips%2C+Kenneth+L%3BPine%2C+P+Scott%3BPusztai%2C+Lajos%3BQian%2C+Feng%3BRen%2C+Hongzu%3BRosen%2C+Mitch%3BRosenzweig%2C+Barry+A%3BSamaha%2C+Raymond+R%3BSchena%2C+Mark%3BSchroth%2C+Gary+P%3BShchegrova%2C+Svetlana%3BSmith%2C+Dave+D%3BStaedtler%2C+Frank%3BSu%2C+Zhenqiang%3BSun%2C+Hongmei%3BSzallasi%2C+Zoltan%3BTezak%2C+Zivana%3BThierry-Mieg%2C+Danielle%3BThompson%2C+Karol+L%3BTikhonova%2C+Irina%3BTurpaz%2C+Yaron%3BVallanat%2C+Beena%3BVan%2C+Christophe%3BWalker%2C+Stephen+J%3BWang%2C+Sue+Jane%3BWang%2C+Yonghong%3BWolfinger%2C+Russ%3BWong%2C+Alex%3BWu%2C+Jie%3BXiao%2C+Chunlin%3BXie%2C+Qian%3BXu%2C+Jun%3BYang%2C+Wen%3BZhang%2C+Liang%3BZhong%2C+Sheng%3BZong%2C+Yaping%3BSlikker%2C+William&rft.aulast=Reid&rft.aufirst=Laura&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; RNA; DNA probes; Quality control; Titration; DNA microarrays DO - http://dx.doi.org/10.1038/nbt1239 ER - TY - JOUR T1 - Evaluation of external RNA controls for the assessment of microarray performance AN - 19317343; 7046482 AB - External RNA controls (ERCs), although important for microarray assay performance assessment, have yet to be fully implemented in the research community. As part of the MicroArray Quality Control (MAQC) study, two types of ERCs were implemented and evaluated; one was added to the total RNA in the samples before amplification and labeling; the other was added to the copyRNAs (cRNAs) before hybridization. ERC concentration-response curves were used across multiple commercial microarray platforms to identify problematic assays and potential sources of variation in the analytical process. In addition, the behavior of different ERC types was investigated, resulting in several important observations, such as the sample-dependent attributes of performance and the potential of using these control RNAs in a combinatorial fashion. This multiplatform investigation of the behavior and utility of ERCs provides a basis for articulating specific recommendations for their future use in evaluating assay performance across multiple platforms. JF - Nature Biotechnology AU - Tong, Weida AU - Lucas, Anne Bergstrom AU - Shippy, Richard AU - Fan, Xiaohui AU - Fang, Hong AU - Hong, Huixiao AU - Orr, Michael S AU - Chu, Tzu-Ming AU - Guo, Xu AU - Collins, Patrick J AU - Sun, Yongming Andrew AU - Wang, Sue-Jane AU - Bao, Wenjun AU - Wolfinger, Russell D AU - Shchegrova, Svetlana AU - Guo, Lei AU - Warrington, Janet A AU - Shi, Leming AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA., weida.tong@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1132 EP - 1139 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - RNA KW - Quality control KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19317343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Evaluation+of+external+RNA+controls+for+the+assessment+of+microarray+performance&rft.au=Tong%2C+Weida%3BLucas%2C+Anne+Bergstrom%3BShippy%2C+Richard%3BFan%2C+Xiaohui%3BFang%2C+Hong%3BHong%2C+Huixiao%3BOrr%2C+Michael+S%3BChu%2C+Tzu-Ming%3BGuo%2C+Xu%3BCollins%2C+Patrick+J%3BSun%2C+Yongming+Andrew%3BWang%2C+Sue-Jane%3BBao%2C+Wenjun%3BWolfinger%2C+Russell+D%3BShchegrova%2C+Svetlana%3BGuo%2C+Lei%3BWarrington%2C+Janet+A%3BShi%2C+Leming&rft.aulast=Tong&rft.aufirst=Weida&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1132&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA microarrays; RNA; Quality control DO - http://dx.doi.org/10.1038/nbt1237 ER - TY - JOUR T1 - Rat toxicogenomic study reveals analytical consistency across microarray platforms AN - 19316101; 7046483 AB - To validate and extend the findings of the MicroArray Quality Control (MAQC) project, a biologically relevant toxicogenomics data set was generated using 36 RNA samples from rats treated with three chemicals (aristolochic acid, riddelliine and comfrey) and each sample was hybridized to four microarray platforms. The MAQC project assessed concordance in intersite and cross-platform comparisons and the impact of gene selection methods on the reproducibility of profiling data in terms of differentially expressed genes using distinct reference RNA samples. The real-world toxicogenomic data set reported here showed high concordance in intersite and cross-platform comparisons. Further, gene lists generated by fold-change ranking were more reproducible than those obtained by t-test P value or Significance Analysis of Microarrays. Finally, gene lists generated by fold-change ranking with a nonstringent P- value cutoff showed increased consistency in Gene Ontology terms and pathways, and hence the biological impact of chemical exposure could be reliably deduced from all platforms analyzed. JF - Nature Biotechnology AU - Guo, Lei AU - Lobenhofer, Edward K AU - Wang, Charles AU - Shippy, Richard AU - Harris, Stephen C AU - Zhang, Lu AU - Mei, Nan AU - Chen, Tao AU - Herman, Damir AU - Goodsaid, Federico M AU - Hurban, Patrick AU - Phillips, Kenneth L AU - Xu, Jun AU - Deng, Xutao AU - Sun, Yongming Andrew AU - Tong, Weida AU - Dragan, Yvonne P AU - Shi, Leming AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA., lei.guo@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1162 EP - 1169 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - rats KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Toxicology Abstracts KW - RNA KW - Quality control KW - Aristolochic acid KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19316101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Rat+toxicogenomic+study+reveals+analytical+consistency+across+microarray+platforms&rft.au=Guo%2C+Lei%3BLobenhofer%2C+Edward+K%3BWang%2C+Charles%3BShippy%2C+Richard%3BHarris%2C+Stephen+C%3BZhang%2C+Lu%3BMei%2C+Nan%3BChen%2C+Tao%3BHerman%2C+Damir%3BGoodsaid%2C+Federico+M%3BHurban%2C+Patrick%3BPhillips%2C+Kenneth+L%3BXu%2C+Jun%3BDeng%2C+Xutao%3BSun%2C+Yongming+Andrew%3BTong%2C+Weida%3BDragan%2C+Yvonne+P%3BShi%2C+Leming&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1238 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - RNA; Quality control; Aristolochic acid DO - http://dx.doi.org/10.1038/nbt1238 ER - TY - JOUR T1 - Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project AN - 19315497; 7046486 AB - Microarray-based expression profiling experiments typically use either a one-color or a two-color design to measure mRNA abundance. The validity of each approach has been amply demonstrated. Here we provide a simultaneous comparison of results from one- and two-color labeling designs, using two independent RNA samples from the Microarray Quality Control (MAQC) project, tested on each of three different microarray platforms. The data were evaluated in terms of reproducibility, specificity, sensitivity and accuracy to determine if the two approaches provide comparable results. For each of the three microarray platforms tested, the results show good agreement with high correlation coefficients and high concordance of differentially expressed gene lists within each platform. Cumulatively, these comparisons indicate that data quality is essentially equivalent between the one- and two-color approaches and strongly suggest that this variable need not be a primary factor in decisions regarding experimental microarray design. JF - Nature Biotechnology AU - Patterson, Tucker A AU - Lobenhofer, Edward K AU - Fulmer-Smentek, Stephanie B AU - Collins, Patrick J AU - Chu, Tzu-Ming AU - Bao, Wenjun AU - Fang, Hong AU - Kawasaki, Ernest S AU - Hager, Janet AU - Tikhonova, Irina R AU - Walker, Stephen J AU - Zhang, Liang AU - Hurban, Patrick AU - De Longueville, Francoise AU - Fuscoe, James C AU - Tong, Weida AU - Shi, Leming AU - Wolfinger, Russell D AD - National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA., tucker.patterson@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1140 EP - 1150 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Abundance KW - DNA microarrays KW - Color KW - mRNA KW - Quality control KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19315497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Performance+comparison+of+one-color+and+two-color+platforms+within+the+Microarray+Quality+Control+%28MAQC%29+project&rft.au=Patterson%2C+Tucker+A%3BLobenhofer%2C+Edward+K%3BFulmer-Smentek%2C+Stephanie+B%3BCollins%2C+Patrick+J%3BChu%2C+Tzu-Ming%3BBao%2C+Wenjun%3BFang%2C+Hong%3BKawasaki%2C+Ernest+S%3BHager%2C+Janet%3BTikhonova%2C+Irina+R%3BWalker%2C+Stephen+J%3BZhang%2C+Liang%3BHurban%2C+Patrick%3BDe+Longueville%2C+Francoise%3BFuscoe%2C+James+C%3BTong%2C+Weida%3BShi%2C+Leming%3BWolfinger%2C+Russell+D&rft.aulast=Patterson&rft.aufirst=Tucker&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1140&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1242 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Quality control; DNA microarrays; Abundance; mRNA; Color DO - http://dx.doi.org/10.1038/nbt1242 ER - TY - JOUR T1 - Serum Brain-Derived Neurotrophic Factor Concentrations in Lean and Overweight Children and Adolescents AN - 19315369; 7062272 AB - CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. Design/Setting/Patients: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean plus or minus SD, 39.8 plus or minus 24.8 vs. 47.0 plus or minus 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function. JF - Journal of Clinical Endocrinology and Metabolism AU - El-Gharbawy, Areeg H AU - Adler-Wailes, Diane C AU - Mirch, Margaret C AU - Theim, Kelly R AU - Ranzenhofer, Lisa AU - Tanofsky-Kraff, Marian AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1103 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3548 EP - 3552 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 91 IS - 9 SN - 0021-972X, 0021-972X KW - Physical Education Index; CSA Neurosciences Abstracts KW - Measurement KW - Age KW - Animal subjects KW - Body mass KW - Body weight KW - Weight KW - Regression analysis KW - Races KW - Sex KW - Brain-derived neurotrophic factor KW - Obesity KW - Enzyme-linked immunosorbent assay KW - Adolescence KW - Multiple regression analysis KW - Patients KW - Children KW - TrkB receptors KW - Energy balance KW - Analysis KW - haploinsufficiency KW - Platelets KW - Adipose tissue KW - Body fat KW - Body mass index KW - Mutation KW - N3 11009:Neuroendocrinology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19315369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Serum+Brain-Derived+Neurotrophic+Factor+Concentrations+in+Lean+and+Overweight+Children+and+Adolescents&rft.au=El-Gharbawy%2C+Areeg+H%3BAdler-Wailes%2C+Diane+C%3BMirch%2C+Margaret+C%3BTheim%2C+Kelly+R%3BRanzenhofer%2C+Lisa%3BTanofsky-Kraff%2C+Marian%3BYanovski%2C+Jack+A&rft.aulast=El-Gharbawy&rft.aufirst=Areeg&rft.date=2006-09-01&rft.volume=91&rft.issue=9&rft.spage=3548&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Age; Weight; Body mass; Animal subjects; Analysis; Adolescence; Patients; Children; Sex; Brain-derived neurotrophic factor; Enzyme-linked immunosorbent assay; Multiple regression analysis; TrkB receptors; Body weight; Energy balance; haploinsufficiency; Regression analysis; Platelets; Body fat; Adipose tissue; Body mass index; Mutation; Races ER - TY - JOUR T1 - Evaluation of DNA microarray results with quantitative gene expression platforms AN - 19312602; 7046481 AB - We have evaluated the performance characteristics of three quantitative gene expression technologies and correlated their expression measurements to those of five commercial microarray platforms, based on the MicroArray Quality Control (MAQC) data set. The limit of detection, assay range, precision, accuracy and fold-change correlations were assessed for 997 TaqMan Gene Expression Assays, 205 Standardized RT (Sta)RT-PCR assays and 244 QuantiGene assays. TaqMan is a registered trademark of Roche Molecular Systems, Inc. We observed high correlation between quantitative gene expression values and microarray platform results and found few discordant measurements among all platforms. The main cause of variability was differences in probe sequence and thus target location. A second source of variability was the limited and variable sensitivity of the different microarray platforms for detecting weakly expressed genes, which affected interplatform and intersite reproducibility of differentially expressed genes. From this analysis, we conclude that the MAQC microarray data set has been validated by alternative quantitative gene expression platforms thus supporting the use of microarray platforms for the quantitative characterization of gene expression. JF - Nature Biotechnology AU - Canales, Roger D AU - Luo, Yuling AU - Willey, James C AU - Austermiller, Bradley AU - Barbacioru, Catalin C AU - Boysen, Cecilie AU - Hunkapiller, Kathryn AU - Jensen, Roderick V AU - Knight, Charles R AU - Lee, Kathleen Y AU - Ma, Yunqing AU - Maqsodi, Botoul AU - Papallo, Adam AU - Peters, Elizabeth Herness AU - Poulter, Karen AU - Ruppel, Patricia L AU - Samaha, Raymond R AU - Shi, Leming AU - Yang, Wen AU - Zhang, Lu AU - Goodsaid, Federico M AD - Applied Biosystems, 850 Lincoln Centre Dr., Foster City, California 94404, USA., Federico.Goodsaid@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1115 EP - 1122 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Gene expression KW - Data processing KW - DNA probes KW - Quality control KW - Probes KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19312602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Evaluation+of+DNA+microarray+results+with+quantitative+gene+expression+platforms&rft.au=Canales%2C+Roger+D%3BLuo%2C+Yuling%3BWilley%2C+James+C%3BAustermiller%2C+Bradley%3BBarbacioru%2C+Catalin+C%3BBoysen%2C+Cecilie%3BHunkapiller%2C+Kathryn%3BJensen%2C+Roderick+V%3BKnight%2C+Charles+R%3BLee%2C+Kathleen+Y%3BMa%2C+Yunqing%3BMaqsodi%2C+Botoul%3BPapallo%2C+Adam%3BPeters%2C+Elizabeth+Herness%3BPoulter%2C+Karen%3BRuppel%2C+Patricia+L%3BSamaha%2C+Raymond+R%3BShi%2C+Leming%3BYang%2C+Wen%3BZhang%2C+Lu%3BGoodsaid%2C+Federico+M&rft.aulast=Canales&rft.aufirst=Roger&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1115&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Quality control; DNA probes; Probes; DNA microarrays DO - http://dx.doi.org/10.1038/nbt1236 ER - TY - JOUR T1 - Heterogeneity of vat(E)-carrying plasmids in Enterococcus faecium recovered from human and animal sources AN - 19296343; 7045450 AB - In this study, quinupristin/dalfopristin (Q/D)-resistant Enterococcus faecium isolates (33 from poultry farms and 1 from a human outpatient) with Q/D minimal inhibitory concentrations ranging from 4 mu g/mL to 32 mu g/mL were analysed. Polymerase chain reaction detected the presence of vat(E) in all isolates. Using pulsed-field gel electrophoresis (PFGE), 14 distinct PFGE patterns were identified. The human E. faecium isolate was distinguishable from the 33 farm isolates by PFGE. Southern hybridisation localised the vat(E) gene to an 11 kb plasmid and resulted in five plasmid hybridisation types. The vat(E)-carrying plasmid from the human isolate showed a nearly identical hybridisation pattern to a plasmid from a farm isolate. This study showed that the vat(E) gene, conferring resistance to Q/D, was carried on different plasmids in a heterogeneous group of E. faecium, some of which may be acquired by E. faecium capable of infecting humans. JF - International Journal of Antimicrobial Agents AU - Simjee, Shabbir AU - Zhang, Yifan AU - McDermott, Patrick F AU - Donabedian, Susan M AU - Zervos, Marcus J AU - Meng, Jianghong AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD, USA, jmeng@umd.edu Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 200 EP - 205 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 28 IS - 3 SN - 0924-8579, 0924-8579 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - E. faecium KW - Plasmids KW - Streptogramin resistance KW - Virginiamycin KW - Dalfopristin KW - Poultry KW - Farms KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - quinupristin KW - Enterococcus faecium KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19296343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Bovine+kidney+tissue%2Fbiological+fluid+correlation+for+penicillin.&rft.au=Chiesa%2C+O+A%3BVon+Bredow%2C+J%3BSmith%2C+M%3BHeller%2C+D%3BCondon%2C+R%3BThomas%2C+M+H&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-08-01&rft.volume=29&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=01407783&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Poultry; Dalfopristin; Farms; Pulsed-field gel electrophoresis; Polymerase chain reaction; quinupristin; Plasmids; Antimicrobial agents; Enterococcus faecium DO - http://dx.doi.org/10.1016/j.ijantimicag.2006.04.004 ER - TY - JOUR T1 - Toxic cyanobacteria in the lakes located in Riga (the capital of Latvia) and its surroundings: present state of knowledge AN - 19292257; 7354439 AB - The intensity and toxicity of cyanobacterial blooms in lakes located near Riga (the capital of Latvia) were investigated between 1998 and 2004. These lakes are shallow eutrophic water bodies with a high surface to depth ratio and are widely used for recreational and fishing activities. Intense cyanobacterial blooms were associated with calm weather, high water temperatures (>20 degree C), and low oxygen saturation in surface (40-70%) and bottom (1-30%) waters. The maximum biomass of harmful cyanobacteria occurred during August-September. Cyanobacterial blooms were dominated by Anabaena spp., Aphanizomenon flos-aquae and Microcystis spp. A significant decrease of the Shannon-Wiener species diversity index was observed during bloom periods. Hepatotoxins (microcystins) were detected in 50% of the surveyed lakes. High-performance liquid chromatography analysis of algal biomass indicated the presence of microcystins MC-LR, MC-YR, MC-RR and MC-LA. The most abundant was MC-LR, contributing on average 43% of the total microcystins. Microcystin concentrations showed a significant interannual variation. The highest concentration of microcystins was observed in Lake Lielais Baltezers. JF - African Journal of Marine Science AU - Balode, M AU - Purina, I AU - Strake, S AU - Purvina, S AU - Pfeifere, M AU - Barda, I AU - Povidisa, K Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 225 EP - 230 VL - 28 IS - 2 SN - 1814-232X, 1814-232X KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Ecology Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - High-performance liquid chromatography KW - Aphanizomenon flos-aquae KW - Algal blooms KW - Eutrophic waters KW - Microcystins KW - Eutrophic environments KW - marine sciences KW - Phytoplankton KW - Anabaena KW - Freshwater KW - Freshwater fish KW - Public health KW - Microcystis KW - Fishing KW - Lakes KW - eutrophic water KW - Latvia KW - Algae KW - Weather KW - Biological poisons KW - microcystins KW - Toxicity KW - Water temperature KW - Biomass KW - Oxygen KW - Cyanobacteria KW - Recreation KW - Liquid chromatography KW - Recreation areas KW - Species diversity KW - fishing KW - Cyanophyta KW - water temperature KW - X 24370:Natural Toxins KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09183:Physics and chemistry KW - K 03450:Ecology KW - Q1 08481:Productivity KW - Q5 08524:Public health, medicines, dangerous organisms KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19292257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=African+Journal+of+Marine+Science&rft.atitle=Toxic+cyanobacteria+in+the+lakes+located+in+Riga+%28the+capital+of+Latvia%29+and+its+surroundings%3A+present+state+of+knowledge&rft.au=Balode%2C+M%3BPurina%2C+I%3BStrake%2C+S%3BPurvina%2C+S%3BPfeifere%2C+M%3BBarda%2C+I%3BPovidisa%2C+K&rft.aulast=Balode&rft.aufirst=M&rft.date=2006-09-01&rft.volume=28&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=African+Journal+of+Marine+Science&rft.issn=1814232X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Algal blooms; Lakes; Recreation; Eutrophic waters; Biological poisons; Phytoplankton; Freshwater fish; Public health; High-performance liquid chromatography; Oxygen; Fishing; Weather; Eutrophic environments; Microcystins; Species diversity; Water temperature; Toxicity; Biomass; Algae; marine sciences; microcystins; Recreation areas; Liquid chromatography; eutrophic water; fishing; water temperature; Microcystis; Aphanizomenon flos-aquae; Cyanobacteria; Anabaena; Cyanophyta; Latvia; Freshwater ER - TY - JOUR T1 - Inhibition of mammalian target of rapamycin modulates expression of adhesion molecules in endothelial cells AN - 17241892; 6969110 AB - Neointimal hyperplasia often follows angioplasty-induced arterial injury or stenting and results in restenosis. Previous reports have suggested that arterial injury activates complement which amplifies inflammatory responses that may initiate and sustain neointimal hyperplasia. The effects of rapamycin on complement-induced expression of intracellular adhesion molecules (ICAMs) were examined in porcine arterial endothelial cell (PAEC) line that was transformed with large T antigen. Porcine complement was activated by treating sera with zymosan (PO ZYM) to generate C5b-9. C5b-9 binds to PAEC in a concentration- and time-dependent manner. PO ZYM-induced expression of ICAMs was maximally induced by 18 h. Rapamycin reduced the expression of vascular cell adhesion molecule (VCAM) and P-selectin in a concentration-dependent manner. Adhesion of monocytes was reduced by rapamycin and the inhibition was prevented by antibodies to vascular cell adhesion molecule, P-selectin and endothelial-leukocyte adhesion molecule (ELAM). In summary, inhibition of the mammalian target of rapamycin down regulates complement-induced ICAMs expression which may modulate inflammatory responses that follow stent implant-induced restenosis during percutanous coronary interventions. JF - Toxicology Letters AU - Wood, Steven C AU - Bushar, Grace AU - Tesfamariam, Belay AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, CDRH, FDA, Building 64, Rm 3026, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA, steven.wood@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 242 EP - 249 PB - Elsevier Science Ireland Ltd., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 165 IS - 3 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Rapamycin KW - Cell adhesion molecules KW - Endothelial cells KW - mTOR signaling KW - Complement KW - restenosis KW - P-selectin KW - Inflammation KW - Hyperplasia KW - Antibodies KW - Monocytes KW - TOR protein KW - Vascular system KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17241892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Inhibition+of+mammalian+target+of+rapamycin+modulates+expression+of+adhesion+molecules+in+endothelial+cells&rft.au=Wood%2C+Steven+C%3BBushar%2C+Grace%3BTesfamariam%2C+Belay&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Antibodies; Hyperplasia; Complement; restenosis; P-selectin; Monocytes; TOR protein; Rapamycin; Cell adhesion molecules; Vascular system; Inflammation DO - http://dx.doi.org/10.1016/j.toxlet.2006.04.009 ER - TY - JOUR T1 - Effects of zearalenone on in utero development in rats AN - 17238341; 6968598 AB - Zearalenone (ZE), an estrogenic mycotoxin produced by Fusarium graminearum or F. roseum, is one of the most common contaminants of cereal grains world-wide. The objective of this study was to determine the effects of ZE on in utero development of rats. Pregnant female Charles River Sprague-Dawley rats were gavaged once daily with ZE (in corn oil) at doses of 0, 1, 2, 4, or 8 mg/kg body weight on gestation days (GD) 6-19. All females survived to cesarean section on GD 20. At cesarean section, reproductive and developmental parameters were measured and blood was taken for hormone analysis. Dose-related decreases were seen in maternal feed consumption and body weight gain in all treated groups. Delayed fetal development was linked to maternal toxicity. Fetal body weight was significantly decreased in both sexes in all treated groups. ZE retarded skeletal ossification at 4 and 8 mg/kg. Fetal anogenital index (anogenital distance normalized for body weight) was increased in all treated groups, indicating an androgenic effect of ZE during fetal development. Fetal viability was significantly decreased at 8 mg/kg; significant decreases were observed in number of viable fetuses, and number of litters totally resorbed. At 4 and 8 mg/kg, maternal liver-body weight ratios were significantly increased and organ-brain weight ratios for weights of liver, heart, spleen, kidneys, and ovaries were significantly decreased. Gonadotropins (LH, FSH, and prolactin) and sex steroids (progesterone and estradiol) were analyzed from the blood serum obtained at cesarean section. LH in the 0, 1, 2, and 4 mg/kg groups showed minimal variation, and slightly increased at 8 mg/kg. FSH was decreased in the 1, 2, and 4 mg/kg groups, but the level at 8 mg/kg was slightly higher than the control level. Prolactin level was not affected at 1 mg/kg, slightly increased at 2 and 4 mg/kg, and significantly increased at 8 mg/kg. Progesterone was decreased at 2, 4, and 8 mg/kg and the decreases were significant at 2 and 4 mg/kg. Estradiol level was not affected at 1 mg/kg, but dose-related decreases were observed at 2, 4, and 8 mg/kg. Only the 8 mg/kg level of estradiol was significantly decreased. In summary, ZE was maternally toxic and fetotoxic but not teratogenic. The increased anogenital distance observed in male and female fetuses was considered a hormonal change rather than a teratologic response. The increased anogenital distance indicated an androgenic effect. Based on the dose- related maternal and fetal toxicity in all treated groups, the NOEL for reproductive and teratogenic effects was less than 1 mg/kg. JF - Food and Chemical Toxicology AU - Collins, Thomas FX AU - Sprando, Robert L AU - Black, Thomas N AU - Olejnik, Nicholas AU - Eppley, Robert M AU - Alam, Hamida Z AU - Rorie, James AU - Ruggles, Dennis I AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA, tcollins@cfsan.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1455 EP - 1465 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 9 SN - 0278-6915, 0278-6915 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Zearalenone KW - Estrogenic mycotoxin KW - Developmental toxicity KW - Rat KW - Follicle-stimulating hormone KW - Progesterone KW - Anogenital KW - Development KW - Hormones KW - Oil KW - Cereals KW - Body weight KW - Gestation KW - Sex KW - Rivers KW - Heart KW - Litter KW - Gonadotropins KW - Spleen KW - Toxicity KW - Steroid hormones KW - Fusarium graminearum KW - Fetuses KW - Estradiol KW - Pregnancy KW - Prolactin KW - Blood KW - Mycotoxins KW - Ossification KW - Liver KW - Kidney KW - Grain KW - Cesarean section KW - Teratogenicity KW - Ovaries KW - Body weight gain KW - Contaminants KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03410:Animal Diseases KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17238341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+zearalenone+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BAlam%2C+Hamida+Z%3BRorie%2C+James%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Zearalenone; Follicle-stimulating hormone; Progesterone; Anogenital; Development; Hormones; Oil; Body weight; Cereals; Gestation; Sex; Heart; Rivers; Litter; Gonadotropins; Spleen; Steroid hormones; Toxicity; Estradiol; Fetuses; Pregnancy; Prolactin; Blood; Mycotoxins; Ossification; Grain; Kidney; Liver; Cesarean section; Teratogenicity; Ovaries; Contaminants; Body weight gain; Fusarium graminearum DO - http://dx.doi.org/10.1016/j.fct.2006.04.015 ER - TY - JOUR T1 - Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma AN - 1709177478; 15622683 AB - In this study, we hypothesized that the altered insulin and glucose levels in male pancreatic cancer patients reported in a recent JAMA article would result in an altered lipid profile in the blood of pancreatic cancer patients when compared to controls (Stolzenberg-Solomon et al., 2005). Proton nuclear magnetic resonance (NMR) spectra of human lipophilic plasma extracts were used in order to build partial least squares discriminant function (PLS-DF) models that classified samples as belonging to the pancreatic control group or to the pancreatic cancer group. The sensitivity, specificity, and overall accuracy of the PLS-DF models based on 4 bins were 96%, 88%, and 92%, respectively. The sensitivity, specificity, and overall accuracy of the PLS-DF models based on 5 bins were 98%, 94%, and 96%, respectively. The sensitivity, specificity and overall accuracy of both the 4-bin and 5-bin PLS-DF models dropped only 1-2% during leave-25%-out cross-validation testing. Mass spectrometric profiling of phospholipids in plasma found three phosphatidylinositols that were significantly lower in pancreatic cancer patients than in healthy controls. The cancer models are based upon changes in lipid profiles that may provide a more sensitive and accurate diagnosis of pancreatic cancer than current methods that are based upon a single biomarker. JF - Metabolomics AU - Beger, Richard D AU - Schnackenberg, Laura K AU - Holland, Ricky D AU - Li, Donghui AU - Dragan, Yvonne AD - Division of Systems Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, 72079-9502, USA, Richard.Beger@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 125 EP - 134 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 2 IS - 3 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Protons KW - phosphatidylinositol KW - Lipids KW - Glucose KW - Pancreatic cancer KW - biomarkers KW - Insulin KW - Lipophilic KW - Models KW - Blood KW - N.M.R. KW - metabolomics KW - Phospholipids KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709177478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabonomic+models+of+human+pancreatic+cancer+using+1D+proton+NMR+spectra+of+lipids+in+plasma&rft.au=Beger%2C+Richard+D%3BSchnackenberg%2C+Laura+K%3BHolland%2C+Ricky+D%3BLi%2C+Donghui%3BDragan%2C+Yvonne&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2006-09-01&rft.volume=2&rft.issue=3&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-006-0026-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - phosphatidylinositol; Protons; Lipids; Pancreatic cancer; Glucose; biomarkers; Lipophilic; Insulin; Models; Blood; N.M.R.; metabolomics; Phospholipids DO - http://dx.doi.org/10.1007/s11306-006-0026-2 ER - TY - CPAPER T1 - Optical Coherence Tomography Signal Enhancement with Gold Nanoshells T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40190772; 4333573 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Agrawal, Anant AU - Lin, Alex AU - Lee, Min-Ho AU - Drezek, Rebekah AU - Pfefer, Josh Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Gold KW - Tomography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40190772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Optical+Coherence+Tomography+Signal+Enhancement+with+Gold+Nanoshells&rft.au=Agrawal%2C+Anant%3BLin%2C+Alex%3BLee%2C+Min-Ho%3BDrezek%2C+Rebekah%3BPfefer%2C+Josh&rft.aulast=Agrawal&rft.aufirst=Anant&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection. AN - 68730360; 16750659 AB - A liquid chromatographic (LC) method for determining 14 sulfonamide (SA) (sulfanilamide, sulfadiazine (SDZ), sulfathiazole, sulfapyridine, sulfamerazine (SMR), sulfamethazine (SMZ), sulfamethizole, sulfamethoxypyridazine, sulfachloropyridazine (SCP), sulfamonomethoxine, sulfadoxine, sulfamethoxazole, sulfadimethoxine (SDM), and sulfaquinoxaline (SQX)) residues in edible catfish, shrimp and salmon tissues was developed and validated at 5, 10 or 20 ng g(-1). The method was then used to determine residues in tissues of catfish, shrimp and salmon dosed with six selected sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine, sulfachloropyridazine, sulfadimethoxine and sulfaquinoxaline). All assays were within U.S. Food and Drug Administration guidelines for recovery and intra-assay variability. The method was developed to determine possible sulfonamide residues in aquacultured catfish, shrimp and salmon produced for food. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Gehring, Theresa A AU - Griffin, Bill AU - Williams, Rod AU - Geiseker, Charles AU - Rushing, Larry G AU - Siitonen, Paul H AD - Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Tgehring@nctr.fda.gov Y1 - 2006/08/18/ PY - 2006 DA - 2006 Aug 18 SP - 132 EP - 138 VL - 840 IS - 2 SN - 1570-0232, 1570-0232 KW - Sulfonamides KW - 0 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Salmon KW - Sulfonamides -- analysis KW - Catfishes KW - Spectrometry, Fluorescence -- methods KW - Drug Residues -- analysis KW - Crustacea KW - Chromatography, High Pressure Liquid -- methods KW - Fish Products -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68730360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Multiresidue+determination+of+sulfonamides+in+edible+catfish%2C+shrimp+and+salmon+tissues+by+high-performance+liquid+chromatography+with+postcolumn+derivatization+and+fluorescence+detection.&rft.au=Gehring%2C+Theresa+A%3BGriffin%2C+Bill%3BWilliams%2C+Rod%3BGeiseker%2C+Charles%3BRushing%2C+Larry+G%3BSiitonen%2C+Paul+H&rft.aulast=Gehring&rft.aufirst=Theresa&rft.date=2006-08-18&rft.volume=840&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-27 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Popcorn worker's lung: in vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine. AN - 68703627; 16545411 AB - Workers who inhale microwave popcorn butter flavorings experience decrements in lung function and can develop clinical bronchiolitis obliterans, i.e., "popcorn worker's lung" (Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E.J., Enright, P.L., 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347, 330-338.). In a rat inhalation model, vapors of an artificial butter flavoring damaged the epithelium of the upper and lower airways (Hubbs, A.F., Battelli, L.A., Goldsmith, W.T., Porter, D.W., Frazer, D., Friend, S., Schwegler-Berry, D., Mercer, R.R., Reynolds, J.S., Grote, A., Castranova, V., Kullman, G., Fedan, J.S., Dowdy, J., Jones, W.G., 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185, 128-135.). Diacetyl, a butter flavoring component, is a major volatile ketone in the popcorn-processing workplace. We investigated the effects of diacetyl on epithelium of guinea pig isolated airway preparations and the effects of diacetyl in vitro on reactivity to bronchoactive agents. In the isolated, perfused trachea preparation, diacetyl added to the intraluminal (mucosal) bath elicited responses that began with contraction (threshold ca. 3 mM) and ended with relaxation. After a 4-h incubation with intraluminal diacetyl (3 mM), contractions to extraluminal (serosal) methacholine (MCh) were slightly increased; however, sensitivity to intraluminally (mucosally) applied MCh was increased by 10-fold. Relaxation responses of MCh (3 x 10(-7) M)-contracted tracheas to extraluminally applied terbutaline and intraluminally applied 120 mM KCl, to evoke epithelium-derived relaxing factor release, were unaffected by diacetyl. Exposure of the tracheal epithelium in Ussing chambers to diacetyl decreased transepithelial potential difference and resistance. These findings suggest that diacetyl exposure compromised epithelial barrier function, leading to hyperreactivity to mucosally applied MCh. The respiratory epithelium appears to serve as an initial target for the toxic effects of diacetyl in the airways. JF - Toxicology and applied pharmacology AU - Fedan, J S AU - Dowdy, J A AU - Fedan, K B AU - Hubbs, A F AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. jsf2@cdc.gov Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 17 EP - 22 VL - 215 IS - 1 SN - 0041-008X, 0041-008X KW - Flavoring Agents KW - 0 KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Butter KW - 8029-34-3 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Trachea -- drug effects KW - Occupational Exposure KW - Methacholine Chloride -- pharmacology KW - Flavoring Agents -- toxicity KW - Diacetyl -- toxicity KW - Lung -- drug effects KW - Food Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Popcorn+worker%27s+lung%3A+in+vitro+exposure+to+diacetyl%2C+an+ingredient+in+microwave+popcorn+butter+flavoring%2C+increases+reactivity+to+methacholine.&rft.au=Fedan%2C+J+S%3BDowdy%2C+J+A%3BFedan%2C+K+B%3BHubbs%2C+A+F&rft.aulast=Fedan&rft.aufirst=J&rft.date=2006-08-15&rft.volume=215&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-20 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - A Theory-Based, Tailored, Interactive Intervention Directed at MSM who Meet Sexual Partners through Internet Chat Sites: Effective for MSM who Practice UAI with Casual Partners T2 - XVI International AIDS Conference (AIDS 2006) AN - 40166790; 4314351 JF - XVI International AIDS Conference (AIDS 2006) AU - Harterink, P AU - Hospers, H AU - Vriens, P AU - Kok, G AU - De Zwart, O Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Internet KW - Sexual partners KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40166790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=A+Theory-Based%2C+Tailored%2C+Interactive+Intervention+Directed+at+MSM+who+Meet+Sexual+Partners+through+Internet+Chat+Sites%3A+Effective+for+MSM+who+Practice+UAI+with+Casual+Partners&rft.au=Chearwae%2C+Wanida%3BShukla%2C+Suneet%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Chearwae&rft.aufirst=Wanida&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaboration with Arab and Muslim-Americans to Break the Silence Surrounding HIV/AIDS T2 - XVI International AIDS Conference (AIDS 2006) AN - 40166548; 4314584 JF - XVI International AIDS Conference (AIDS 2006) AU - Gomez, M AU - Samuels-Atse, S Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40166548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Collaboration+with+Arab+and+Muslim-Americans+to+Break+the+Silence+Surrounding+HIV%2FAIDS&rft.au=Gomez%2C+M%3BSamuels-Atse%2C+S&rft.aulast=Gomez&rft.aufirst=M&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loop Deletions in gp120 Expose the CD4 Binding Site for Improved Binding of 1b12 and F105 Antibodies T2 - XVI International AIDS Conference (AIDS 2006) AN - 40150157; 4314435 JF - XVI International AIDS Conference (AIDS 2006) AU - Berkower, I AU - Ni, Y. AU - Patel, C AU - Spadaccini, A Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Antibodies KW - Deletion KW - CD4 antigen KW - Glycoprotein gp120 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Loop+Deletions+in+gp120+Expose+the+CD4+Binding+Site+for+Improved+Binding+of+1b12+and+F105+Antibodies&rft.au=Berkower%2C+I%3BNi%2C+Y.%3BPatel%2C+C%3BSpadaccini%2C+A&rft.aulast=Berkower&rft.aufirst=I&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells. AN - 68940582; 17031537 AB - Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are a new class of oral drugs designed to treat insulin-resistant diabetes (i.e., type 2 diabetes). However, troglitazone, the first compound in the class approved by the US Food and Drug Administration (FDA) in 1997 was found to be hepatotoxic and was withdrawn from the market after reports of severe liver failure. The mechanism of PPAR gamma agonist-induced hepatotoxicity remains unknown. In this study, we examined the hepatotoxic effects of five PPAR gamma agonists (ciglitazone, pioglitazone, rosiglitazone, troglitazone, and JTT-501) on rat primary hepatocytes and human HepG2 cells. We also compared the gene expression profiles of rat primary hepatocytes after exposure to PPAR gamma agonists by using the Rat Genome Survey Microarray system from Applied Biosystems in order to understand the mechanisms of hepatotoxicities induced by PPARgamma agonists. Consistent with the hepatotoxicity data, our results demonstrate that the gene expression profiles affected by troglitazone and ciglitazone can be clearly distinguished from those by pioglitazone and rosiglitazone. Genes that are differentially expressed between the more toxic troglitazone/ciglitazone group and the less toxic rosiglitazone/pioglitazone group are involved in necrotic, apoptotic, and cell proliferative pathways. The five compounds were also clustered based on a set of molecular descriptors. The clustering based on chemical structural information is in good agreement with the clustering of compounds based on cytotoxicity or gene expression data, indicating a strong relationship between chemical structure and biological endpoints. Our work suggests that microarray analysis together with toxicological observations can be used to rank drugs for hepatotoxicity and to evaluate the safety of new compounds. JF - Molecular diversity AU - Guo, Lei AU - Zhang, Lu AU - Sun, Yongming AU - Muskhelishvili, Levan AU - Blann, Ernice AU - Dial, Stacey AU - Shi, Leming AU - Schroth, Gary AU - Dragan, Yvonne P AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. lei.guo@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 349 EP - 360 VL - 10 IS - 3 SN - 1381-1991, 1381-1991 KW - Chromans KW - 0 KW - Hypoglycemic Agents KW - PPAR gamma KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - troglitazone KW - I66ZZ0ZN0E KW - ciglitazone KW - U8QXS1WU8G KW - pioglitazone KW - X4OV71U42S KW - Index Medicus KW - Animals KW - Chromans -- toxicity KW - Liver Neoplasms -- metabolism KW - Humans KW - Transcription, Genetic KW - Cells, Cultured -- drug effects KW - Thiazolidinediones -- toxicity KW - Rats KW - Carcinoma, Hepatocellular -- metabolism KW - Rats, Sprague-Dawley KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Cluster Analysis KW - Gene Expression Profiling KW - Hepatocytes -- drug effects KW - Hypoglycemic Agents -- toxicity KW - Gene Expression Regulation -- drug effects KW - PPAR gamma -- agonists KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68940582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+diversity&rft.atitle=Differences+in+hepatotoxicity+and+gene+expression+profiles+by+anti-diabetic+PPAR+gamma+agonists+on+rat+primary+hepatocytes+and+human+HepG2+cells.&rft.au=Guo%2C+Lei%3BZhang%2C+Lu%3BSun%2C+Yongming%3BMuskhelishvili%2C+Levan%3BBlann%2C+Ernice%3BDial%2C+Stacey%3BShi%2C+Leming%3BSchroth%2C+Gary%3BDragan%2C+Yvonne+P&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2006-08-01&rft.volume=10&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Molecular+diversity&rft.issn=13811991&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-25 N1 - Date created - 2006-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A federal perspective on the abuse of prescription stimulants. AN - 68869678; 16986454 JF - Pediatric annals AU - Clark, H Westley AU - Bizzell, Anton C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD 20857, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 594 EP - 597 VL - 35 IS - 8 SN - 0090-4481, 0090-4481 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Child KW - Adolescent KW - United States -- epidemiology KW - Central Nervous System Stimulants -- administration & dosage KW - Substance-Related Disorders -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68869678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+annals&rft.atitle=A+federal+perspective+on+the+abuse+of+prescription+stimulants.&rft.au=Clark%2C+H+Westley%3BBizzell%2C+Anton+C&rft.aulast=Clark&rft.aufirst=H&rft.date=2006-08-01&rft.volume=35&rft.issue=8&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-006-9117-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anisotropic imaging performance in indirect x-ray imaging detectors. AN - 68845896; 16967568 AB - We report on the variability in imaging system performance due to oblique x-ray incidence, and the associated transport of quanta (both x rays and optical photons) through the phosphor, in columnar indirect digital detectors. The analysis uses MANTIS, a combined x-ray, electron, and optical Monte Carlo transport code freely available. We describe the main features of the simulation method and provide some validation of the phosphor screen models considered in this work. We report x-ray and electron three-dimensional energy deposition distributions and point-response functions (PRFs), including optical spread in columnar phosphor screens of thickness 100 and 500 microm, for 19, 39, 59, and 79 keV monoenergetic x-ray beams incident at 0 degrees, 10 degrees, and 15 degrees. In addition, we present pulse-height spectra for the same phosphor thickness, x-ray energies, and angles of incidence. Our results suggest that the PRF due to the phosphor blur is highly nonsymmetrical, and that the resolution properties of a columnar screen in a tomographic, or tomosynthetic imaging system varies significantly with the angle of x-ray incidence. Moreover, we find that the noise due to the variability in the number of light photons detected per primary x-ray interaction, summarized in the information or Swank factor, is somewhat independent of thickness and incidence angle of the x-ray beam. Our results also suggest that the anisotropy in the PRF is not less in screens with absorptive backings, while the noise introduced by variations in the gain and optical transport is larger. Predictions from MANTIS, after additional validation, can provide the needed understanding of the extent of such variations, and eventually, lead to the incorporation of the changes in imaging performance with incidence angle into the reconstruction algorithms for volumetric x-ray imaging systems. JF - Medical physics AU - Badano, Aldo AU - Kyprianou, Iacovos S AU - Sempau, Josep AD - Division of Imaging and Applied Mathematics, Office of Science and Engineering Labs, Center for Devices and Radiological Health, U.S. Food & Drug Administration, 12720 Twinbrook Parkway, Rockville, Maryland 20857, USA. aldo.badano@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 2698 EP - 2713 VL - 33 IS - 8 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Equipment Design KW - Computer Simulation KW - Anisotropy KW - Reproducibility of Results KW - Equipment Failure Analysis KW - Monte Carlo Method KW - Image Interpretation, Computer-Assisted -- methods KW - Transducers KW - Radiographic Image Enhancement -- instrumentation KW - Radiographic Image Enhancement -- methods KW - Models, Statistical KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Anisotropic+imaging+performance+in+indirect+x-ray+imaging+detectors.&rft.au=Badano%2C+Aldo%3BKyprianou%2C+Iacovos+S%3BSempau%2C+Josep&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2006-08-01&rft.volume=33&rft.issue=8&rft.spage=2698&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-09-12 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 ER - TY - JOUR T1 - Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth. AN - 68792175; 16606643 AB - To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1,712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP). The highest prenatal concentrations of p,p'-DDE (>or=60 microg/l), as compared with the lowest (<15 microg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1,540], 4 years [-1.14 cm (0.56), n = 1,289], and 7 years [-2.19 (0.46), n = 1,371]. Among subjects in lower categories of exposure no association was observed. The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected. JF - International journal of epidemiology AU - Ribas-Fitó, Núria AU - Gladen, Beth C AU - Brock, John W AU - Klebanoff, Mark A AU - Longnecker, Matthew P AD - Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA. nribas@imim.es Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 853 EP - 858 VL - 35 IS - 4 SN - 0300-5771, 0300-5771 KW - Environmental Pollutants KW - 0 KW - Insecticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Index Medicus KW - Sex Factors KW - Humans KW - Linear Models KW - African Americans KW - Child KW - Maternal Exposure KW - Pregnancy KW - Child, Preschool KW - Infant KW - Prospective Studies KW - European Continental Ancestry Group KW - Adult KW - Case-Control Studies KW - Body Height -- drug effects KW - Female KW - Male KW - Insecticides -- toxicity KW - Environmental Pollutants -- toxicity KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Growth -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68792175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Prenatal+exposure+to+1%2C1-dichloro-2%2C2-bis+%28p-chlorophenyl%29ethylene+%28p%2Cp%27-DDE%29+in+relation+to+child+growth.&rft.au=Ribas-Fit%C3%B3%2C+N%C3%BAria%3BGladen%2C+Beth+C%3BBrock%2C+John+W%3BKlebanoff%2C+Mark+A%3BLongnecker%2C+Matthew+P&rft.aulast=Ribas-Fit%C3%B3&rft.aufirst=N%C3%BAria&rft.date=2006-08-01&rft.volume=35&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-13 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Epidemiol. 2006 Aug;35(4):858-61 [16847017] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. AN - 68788344; 16930414 AB - Induction of the immediate early gene protein product Fos has been used extensively to assess neural activation in the striatum after repeated cocaine administration to rats in their home cages but rarely after repeated administration outside the home cage, which produces more robust locomotor sensitization. In the present study, we found cocaine-induced Fos expression in nucleus accumbens, but not caudate-putamen, was enhanced 1 and 6 months after repeated drug administration in locomotor activity chambers. Double-labelling of Fos protein and enkephalin mRNA indicated that Fos expression in nucleus accumbens was enhanced in enkephalin-positive, but not enkephalin-negative, medium spiny neurons. In contrast, cocaine-induced Fos expression was absent altogether in nucleus accumbens and unaltered in caudate-putamen 1 month after repeated cocaine administration in the home cage. As cocaine-induced locomotor activity was also enhanced 1 and 6 months after repeated cocaine administration in locomotor activity chambers, we wanted to confirm that neuronal activity in nucleus accumbens mediates cocaine-induced locomotor activity using our particular treatment regimen. Bilateral infusions of the GABA agonists baclofen and muscimol (1 microg/side) into nucleus accumbens of sensitized rats blocked cocaine-induced Fos expression and locomotor activity. Thus, while neuronal activity in both D1- and D2-type neurons in nucleus accumbens can mediate acute cocaine-induced locomotor activity, the enhanced activation of enkephalinergic D2-type neurons suggests that these latter neurons mediate the enhancement of cocaine-induced locomotor activity for up to 6 months after repeated drug administration outside the home cage. JF - The European journal of neuroscience AU - Hope, Bruce T AU - Simmons, Danielle E AU - Mitchell, Tim B AU - Kreuter, Justin D AU - Mattson, Brandi J AD - Behavioural Neuroscience Branch, Intramural Research Program, The National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. bhope@intra.nida.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 867 EP - 875 VL - 24 IS - 3 SN - 0953-816X, 0953-816X KW - Dopamine Uptake Inhibitors KW - 0 KW - Enkephalins KW - GABA Agonists KW - Proto-Oncogene Proteins c-fos KW - Receptors, Dopamine D2 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Drug Administration Schedule KW - Dopamine Uptake Inhibitors -- adverse effects KW - Disease Models, Animal KW - Drug Interactions -- physiology KW - Receptors, Dopamine D2 -- metabolism KW - Up-Regulation -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Neostriatum -- metabolism KW - Time KW - GABA Agonists -- pharmacology KW - Up-Regulation -- drug effects KW - Neostriatum -- drug effects KW - Receptors, Dopamine D2 -- drug effects KW - Enkephalins -- metabolism KW - Gene Expression -- physiology KW - Time Factors KW - Male KW - Proto-Oncogene Proteins c-fos -- drug effects KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Nucleus Accumbens -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Nucleus Accumbens -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Cocaine-induced+locomotor+activity+and+Fos+expression+in+nucleus+accumbens+are+sensitized+for+6+months+after+repeated+cocaine+administration+outside+the+home+cage.&rft.au=Hope%2C+Bruce+T%3BSimmons%2C+Danielle+E%3BMitchell%2C+Tim+B%3BKreuter%2C+Justin+D%3BMattson%2C+Brandi+J&rft.aulast=Hope&rft.aufirst=Bruce&rft.date=2006-08-01&rft.volume=24&rft.issue=3&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humans. AN - 68788151; 16934071 AB - Cross-species infection of humans with simian foamy virus (SFV) has been reported in European and North American nonhuman primate (NHP) handlers, primarily due to wound injuries involving infected animals in research centers and zoos. Additionally, African hunters have been found to be infected with SFV by exposure to body fluids, blood, or tissues of infected NHPs in the wild. The persistence of infectious virus in peripheral blood mononuclear cells (PBMNC) and the recent identification of some infected blood donors has raised safety concerns regarding potential virus transmission by blood transfusion. SFV infection by blood transfusion was evaluated by whole-blood transfer from two naturally-infected rhesus macaques (designated as D1 and D2) to retrovirus-free monkeys. Blood from D1 was transfused to two recipient monkeys R1 and R2 and from D2 to monkeys R3 and R4. Virus transmission was evaluated by immunoassays, polymerase chain reaction assays, and coculture of PBMNC for SFV isolation. SFV infection was seen in R1 and R2 based on development of virus-specific antibodies, identification of SFV sequences in monkey PBMNC, and isolation of infectious virus from PBMNC. Furthermore, both R1 and R2 remained SFV-positive at about 1 year after transfusion, which was the last time tested. No evidence of SFV infection was seen in R3 and R4. SFV transmission in macaques occurred by transfusion of blood from one of two infected donor animals. These results indicate the potential of SFV transfusion transmission in humans, which may depend on virus-specific or donor-related factors. JF - Transfusion AU - Khan, Arifa S AU - Kumar, Dhanya AD - Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA. arifa.khan@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1352 EP - 1359 VL - 46 IS - 8 SN - 0041-1132, 0041-1132 KW - Antibodies, Viral KW - 0 KW - RNA, Viral KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Coculture Techniques KW - Animals, Zoo -- blood KW - Humans KW - Disease Models, Animal KW - Leukocytes, Mononuclear -- immunology KW - Antibodies, Viral -- immunology KW - Antibodies, Viral -- blood KW - Animals, Zoo -- virology KW - Leukocytes, Mononuclear -- virology KW - Cells, Cultured KW - Macaca mulatta KW - RNA, Viral -- blood KW - Spumavirus -- isolation & purification KW - Retroviridae Infections -- immunology KW - Blood Transfusion -- adverse effects KW - Zoonoses -- virology KW - Retroviridae Infections -- transmission KW - Retroviridae Infections -- blood KW - Spumavirus -- immunology KW - Zoonoses -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Simian+foamy+virus+infection+by+whole-blood+transfer+in+rhesus+macaques%3A+potential+for+transfusion+transmission+in+humans.&rft.au=Khan%2C+Arifa+S%3BKumar%2C+Dhanya&rft.aulast=Khan&rft.aufirst=Arifa&rft.date=2006-08-01&rft.volume=46&rft.issue=8&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-22 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Transfusion. 2007 May;47(5):949-50 [17465966] Transfusion. 2006 Aug;46(8):1276-8 [16934059] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin. AN - 68782130; 16928820 AB - Curcumin (curcumin I), demethoxycurcumin (curcumin II), and bisdemethoxycurcumin (curcumin III) are the major forms of curcuminoids found in the turmeric powder, which exhibit anticancer, antioxidant, and anti-inflammatory activities. In this study, we evaluated the ability of purified curcuminoids to modulate the function of either the wild-type 482R or the mutant 482T ABCG2 transporter stably expressed in HEK293 cells and drug-selected MCF-7 FLV1000 and MCF-7 AdVp3000 cells. Curcuminoids inhibited the transport of mitoxantrone and pheophorbide a from ABCG2-expressing cells. However, both cytotoxicity and [(3)H]curcumin I accumulation assays showed that curcuminoids are not transported by ABCG2. Nontoxic concentration of curcumin I, II, and III sensitized the ABCG2-expressing cells to mitoxantrone, topotecan, SN-38, and doxorubicin. This reversal was not due to reduced expression because ABCG2 protein levels were unaltered by treatment with 10 mumol/L curcuminoids for 72 hours. Curcumin I, II, and III stimulated (2.4- to 3.3-fold) ABCG2-mediated ATP hydrolysis and the IC(50)s were in the range of 7.5 to 18 nmol/L, suggesting a high affinity of curcuminoids for ABCG2. Curcuminoids also inhibited the photolabeling of ABCG2 with [(125)I]iodoarylazidoprazosin and [(3)H]azidopine as well as the transport of these two substrates in ABCG2-expressing cells. Curcuminoids did not inhibit the binding of [alpha-(32)P]8-azidoATP to ABCG2, suggesting that they do not interact with the ATP-binding site of the transporter. Collectively, these data show that, among curcuminoids, curcumin I is the most potent modulator of ABCG2 and thus should be considered as a treatment to increase the efficacy of conventional chemotherapeutic drugs. JF - Molecular cancer therapeutics AU - Chearwae, Wanida AU - Shukla, Suneet AU - Limtrakul, Pornngarm AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute/NIH, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1995 EP - 2006 VL - 5 IS - 8 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Anticarcinogenic Agents KW - Azides KW - Dihydropyridines KW - Neoplasm Proteins KW - Chlorophyll KW - 1406-65-1 KW - 8-azidoadenosine 5'-triphosphate KW - 53696-59-6 KW - azidopine KW - 63XR70204A KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - azidoprazosin KW - 90990-97-9 KW - Mitoxantrone KW - BZ114NVM5P KW - pheophorbide a KW - IA2WNI2HO2 KW - Curcumin KW - IT942ZTH98 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Prazosin -- metabolism KW - Prazosin -- analogs & derivatives KW - Chlorophyll -- metabolism KW - Mitoxantrone -- metabolism KW - Humans KW - Biological Transport KW - Dihydropyridines -- metabolism KW - Hydrolysis KW - Azides -- metabolism KW - Tumor Cells, Cultured KW - Adenosine Triphosphate -- analogs & derivatives KW - Adenosine Triphosphate -- metabolism KW - Toxicity Tests KW - Chlorophyll -- analogs & derivatives KW - Mutation KW - Neoplasm Proteins -- drug effects KW - ATP-Binding Cassette Transporters -- drug effects KW - Curcumin -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - Anticarcinogenic Agents -- pharmacology KW - ATP-Binding Cassette Transporters -- genetics KW - Drug Resistance, Neoplasm KW - Neoplasm Proteins -- metabolism KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68782130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Modulation+of+the+function+of+the+multidrug+resistance-linked+ATP-binding+cassette+transporter+ABCG2+by+the+cancer+chemopreventive+agent+curcumin.&rft.au=Chearwae%2C+Wanida%3BShukla%2C+Suneet%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Chearwae&rft.aufirst=Wanida&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interpreting periodic lung function tests in individuals: the relationship between 1- to 5-year and long-term FEV1 changes. AN - 68742922; 16899850 AB - Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV(1) declines. We sought to describe the relationship between FEV(1) changes over 1 to 5 years and FEV(1) declines over longer terms, using 21,821 test results from 1,884 workers who participated in an annual health monitoring program at a chemical plant between 1973 and 2003. Test results from workers with five or more valid results over > or = 10 years were included in our analysis (mean initial worker age, 35 years; range, 18 to 62 years; 91% male; 35% current smokers and 41% nonsmokers). For each worker, long-term FEV(1) slopes (milliliters per year) were calculated by simple linear regression using all available results and compared to changes in FEV(1) between two tests over 1 to 5 years, expressed in both milliliters and percentage of initial value. Long-term (mean, 18 years; range, 10 to 30 years) slopes averaged - 29.1 mL/yr (- 27, - 29, and - 37 mL/yr for male never-smokers, former smokers, and current smokers, and - 20, - 26, and - 27 mL/yr for female never-smokers, former smokers, and current smokers, respectively). Excessive short-term and long-term declines were defined by lower fifth percentile values. Individuals with abnormal short-term declines were found to be 3 to 18 times more likely to ultimately show excessive long-term declines; with the strength of the association increasing with the length of the short-term testing interval. Better test operating characteristics resulted if abnormal short-term FEV(1) change was based on percentage change (ie, percentage per year) rather than absolute change (ie, milliliters per year). Our findings provide guidance for interpreting periodic spirometry results from individuals exposed to respiratory hazards. JF - Chest AU - Wang, Mei Lin AU - Avashia, Bipin H AU - Petsonk, Edward L AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 493 EP - 499 VL - 130 IS - 2 SN - 0012-3692, 0012-3692 KW - Abridged Index Medicus KW - Index Medicus KW - Spirometry KW - Reproducibility of Results KW - Humans KW - Adult KW - Disease Progression KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Lung Diseases -- diagnosis KW - Occupational Diseases -- physiopathology KW - Lung Diseases -- physiopathology KW - Forced Expiratory Volume -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68742922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Interpreting+periodic+lung+function+tests+in+individuals%3A+the+relationship+between+1-+to+5-year+and+long-term+FEV1+changes.&rft.au=Wang%2C+Mei+Lin%3BAvashia%2C+Bipin+H%3BPetsonk%2C+Edward+L&rft.aulast=Wang&rft.aufirst=Mei&rft.date=2006-08-01&rft.volume=130&rft.issue=2&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The medical response to trench nephritis in World War One. AN - 68733634; 16820794 AB - Around the 90-year anniversary of the Battle of the Somme, it is important to remember the international effort that went into responding to the new diseases, which appeared during the First World War, such as trench nephritis. This condition arose among soldiers in spring 1915, characterized by breathlessness, swelling of the face or legs, headache, sore throat, and the presence of albumin and renal casts in urine. It was speedily investigated by the military-medical authorities. There was debate over whether it was new condition or streptococcal nephritis, and the experts agreed that it was a new condition. The major etiologies proposed were infection, exposure, and diet (including poisons). Research pointed to the origin of the disease as being infective rather than toxic, but no definite cause was discovered. A number of labels were given to the disease, including war nephritis. However, trench nephritis was the one used most widely. Trench nephritis was a serious problem for the Allies, leading to 35 000 casualties in the British and 2000 in the American forces. There were also hundreds of deaths. The condition was treated in line with pre-war regimens designed for acute nephritis. No significant preventative methods were implemented for trench nephritis, as there was no consensus regarding causation. The medical response to trench nephritis was largely ineffective, with medical commentators recognizing that there had been a lack of medical progress. JF - Kidney international AU - Atenstaedt, R L AD - National Public Health Service for Wales and Institute of Medical and Social Care Research (IMSCaR), University of Wales, Bangor, UK. Robert.Atenstaedt@nphs.wales.nhs.uk Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 635 EP - 640 VL - 70 IS - 4 SN - 0085-2538, 0085-2538 KW - Index Medicus KW - History, 20th Century KW - Humans KW - Incidence KW - Europe -- epidemiology KW - Nephritis -- epidemiology KW - Nephritis -- therapy KW - Nephritis -- etiology KW - World War I KW - Military Medicine -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=The+medical+response+to+trench+nephritis+in+World+War+One.&rft.au=Atenstaedt%2C+R+L&rft.aulast=Atenstaedt&rft.aufirst=R&rft.date=2006-08-01&rft.volume=70&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-26 N1 - Date created - 2006-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco use in adult long-term survivors of retinoblastoma. AN - 68719311; 16896033 AB - A significant risk of lung cancer was identified among hereditary, but not nonhereditary, retinoblastoma (Rb) patients. Tobacco use was investigated to determine whether differences in smoking prevalence might explain the lung cancer excess and to characterize smoking patterns in adult survivors of Rb. Subjects were 441 hereditary and 395 nonhereditary 1-year survivors of Rb, age >or=18 years, who responded to a telephone survey about current health behavior, including tobacco use. Response rates were 76% for hereditary and 73% for nonhereditary survivors. We compared patterns and predictors of current tobacco use among hereditary and nonhereditary survivors with other childhood cancer survivor studies and the U.S. population. Hereditary Rb survivors currently smoke cigarettes significantly less frequently than nonhereditary survivors (16. 8% versus 24.3%), although among current smokers, age at smoking initiation (17 years old) and average cigarettes (1.5 packs) smoked daily are similar. Predictors of current and ever cigarette smoking include nonhereditary Rb, older age, being female, less education, and use of other tobacco products. Rb survivors smoke cigarettes significantly less than the U.S. population (rate ratio, 0.63; 95% confidence interval, 0.5-0.8 for males; rate ratio, 0.75; 95% confidence interval, 0.6-0.9 for females), but Rb survivors have comparable smoking rates with other childhood cancer survivors. Smoking did not account for the increased risk of lung cancer among hereditary Rb patients, and this may point to an enhanced sensitivity to the carcinogenic effects of tobacco. Adult survivors of Rb should be encouraged to stop smoking. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Foster, Meredith C AU - Kleinerman, Ruth A AU - Abramson, David H AU - Seddon, Johanna M AU - Tarone, Robert E AU - Tucker, Margaret A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7044, 6120 Executive Boulevard, Rockville, MD 20852, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1464 EP - 1468 VL - 15 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Retinoblastoma -- mortality KW - Retinal Neoplasms -- mortality KW - Retinal Neoplasms -- epidemiology KW - Survivors KW - Smoking -- epidemiology KW - Retinoblastoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68719311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Tobacco+use+in+adult+long-term+survivors+of+retinoblastoma.&rft.au=Foster%2C+Meredith+C%3BKleinerman%2C+Ruth+A%3BAbramson%2C+David+H%3BSeddon%2C+Johanna+M%3BTarone%2C+Robert+E%3BTucker%2C+Margaret+A&rft.aulast=Foster&rft.aufirst=Meredith&rft.date=2006-08-01&rft.volume=15&rft.issue=8&rft.spage=1464&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. AN - 68718683; 16797171 AB - Transdermal drug delivery systems (TDDS), also known as "patches," are dosage forms designed to deliver a therapeutically effective amount of drug across a patient's skin. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. In the Drug Quality Reporting System (DQRS), the United States Food and Drug Administration (FDA) has received numerous reports of "adhesion lacking" for transdermal drug delivery systems. This article provides an overview of types of transdermals, their anatomy, the role of adhesion, the possible adhesion failure modes and how adhesion can be measured. Excerpts from FDA reports on the lack of adhesion of transdermal system products are presented. Pros and cons of in vitro techniques, such as peel adhesion, tack and shear strength, in vivo techniques used to evaluate adhesive properties are discussed. To see a decrease in "adhesion lacking" reports, adhesion needs to become an important design parameter and suitable methods need to be available to assess quality and in vivo performance. This article provides a framework for further discussion and scientific work to improve transdermal adhesive performance. JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V AU - Wokovich, Anna M AU - Prodduturi, Suneela AU - Doub, William H AU - Hussain, Ajaz S AU - Buhse, Lucinda F AD - Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA. anna.wokovich@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1 EP - 8 VL - 64 IS - 1 SN - 0939-6411, 0939-6411 KW - Delayed-Action Preparations KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - United States KW - Chemistry, Pharmaceutical KW - Adverse Drug Reaction Reporting Systems KW - Skin Absorption KW - Humans KW - Safety KW - Quality Control KW - Administration, Cutaneous KW - Technology, Pharmaceutical -- methods KW - Drug Delivery Systems -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68718683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmaceutics+and+biopharmaceutics+%3A+official+journal+of+Arbeitsgemeinschaft+fur+Pharmazeutische+Verfahrenstechnik+e.V&rft.atitle=Transdermal+drug+delivery+system+%28TDDS%29+adhesion+as+a+critical+safety%2C+efficacy+and+quality+attribute.&rft.au=Wokovich%2C+Anna+M%3BProdduturi%2C+Suneela%3BDoub%2C+William+H%3BHussain%2C+Ajaz+S%3BBuhse%2C+Lucinda+F&rft.aulast=Wokovich&rft.aufirst=Anna&rft.date=2006-08-01&rft.volume=64&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmaceutics+and+biopharmaceutics+%3A+official+journal+of+Arbeitsgemeinschaft+fur+Pharmazeutische+Verfahrenstechnik+e.V&rft.issn=09396411&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994. AN - 68706334; 16882527 AB - Volatile organic compounds (VOCs) are present in much higher concentrations indoors, where people spend most of their time, than outdoors and may have adverse health effects. VOCs have been associated with respiratory symptoms, but few studies address objective respiratory end points such as pulmonary function. Blood levels of VOCs may be more indicative of personal exposures than are air concentrations; no studies have addressed their relationship with respiratory outcomes. We examined whether concentrations of 11 VOCs that were commonly identified in blood from a sample of the U.S. population were associated with pulmonary function. We used data from 953 adult participants (20-59 years of age) in the Third National Health and Nutrition Examination Survey (1988-1994) who had VOC blood measures as well as pulmonary function measures. Linear regression models were used to evaluate the relationship between 11 VOCs and measures of pulmonary function. After adjustment for smoking, only 1,4-dichlorobenzene (1,4-DCB) was associated with reduced pulmonary function. Participants in the highest decile of 1,4-DCB concentration had decrements of -153 mL [95% confidence interval (CI) , -297 to -8] in forced expiratory volume in 1 sec and -346 mL/sec (95% CI, -667 to -24) in maximum mid-expiratory flow rate, compared with participants in the lowest decile. Exposure to 1,4-DCB, a VOC related to the use of air fresheners, toilet bowl deodorants, and mothballs, at levels found in the U.S. general population, may result in reduced pulmonary function. This common exposure may have long-term adverse effects on respiratory health. JF - Environmental health perspectives AU - Elliott, Leslie AU - Longnecker, Matthew P AU - Kissling, Grace E AU - London, Stephanie J AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709-2233, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1210 EP - 1214 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Organic Chemicals KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Regression Analysis KW - Humans KW - Adult KW - Middle Aged KW - Forced Expiratory Volume -- physiology KW - Environmental Exposure -- adverse effects KW - United States -- epidemiology KW - Smoking -- epidemiology KW - Male KW - Female KW - Health Surveys KW - Organic Chemicals -- analysis KW - Nutrition Surveys KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68706334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Volatile+organic+compounds+and+pulmonary+function+in+the+Third+National+Health+and+Nutrition+Examination+Survey%2C+1988-1994.&rft.au=Elliott%2C+Leslie%3BLongnecker%2C+Matthew+P%3BKissling%2C+Grace+E%3BLondon%2C+Stephanie+J&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Environ Med. 1995 Jun;52(6):388-95 [7627316] Environ Health Perspect. 2006 Mar;114(3):453-9 [16507471] J Anal Toxicol. 1995 Sep;19(5):323-9 [7500620] BMJ. 1996 Sep 21;313(7059):711-5; discussion 715-6 [8819439] Int Arch Occup Environ Health. 1997;69(2):115-24 [9001918] Arch Environ Health. 1997 Jan-Feb;52(1):26-33 [9039854] Chem Biol Interact. 1997 Jan 24;103(1):17-33 [9051121] AMA Arch Ind Health. 1956 Aug;14(2):138-47 [13353999] Arch Environ Health. 2003 Oct;58(10):633-41 [15562635] Clin Exp Allergy. 1997 Nov;27(11):1270-8 [9420130] Int J Occup Environ Health. 2000 Jan-Mar;6(1):1-8 [10637531] Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):665-73 [10673213] Int J Hyg Environ Health. 2000 Mar;203(1):23-8 [10956586] Arch Environ Health. 2001 Mar-Apr;56(2):157-66 [11339680] Environ Health Perspect. 2002 Aug;110(8):765-70 [12153756] Am J Epidemiol. 2002 Oct 15;156(8):738-46 [12370162] Environ Health Perspect. 2003 Apr;111(4):647-56 [12676630] Thorax. 2003 Nov;58(11):955-60 [14586048] Thorax. 2004 Sep;59(9):746-51 [15333849] Environ Res. 1987 Aug;43(2):290-307 [3608934] Am J Public Health. 1989 Mar;79(3):340-9 [2916724] Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):751-4 [2008987] Arch Environ Health. 1992 Jan-Feb;47(1):39-44 [1540001] Anal Chem. 1992 May 1;64(9):1021-9 [1590585] Environ Health Perspect. 1991 Nov;95:7-13 [1821381] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):157-92 [1824315] Clin Chem. 1994 Jul;40(7 Pt 2):1376-84 [8013122] Clin Chem. 1994 Jul;40(7 Pt 2):1401-4 [8013127] Environ Health Perspect. 2005 Mar;113(3):342-9 [15743726] Environ Health Perspect. 2005 Nov;113(11):1542-8 [16263509] Arch Environ Health. 1995 Jul-Aug;50(4):277-80 [7677426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to cyanazine in the agricultural health study. AN - 68703795; 16882534 AB - Cyanazine is a common pesticide used frequently in the United States during the 1980s and 1990s. Animal and human studies have suggested that triazines may be carcinogenic, but results have been mixed. We evaluated cancer incidence in cyanazine-exposed pesticide applicators among the 57,311 licensed pesticide applicators in the Agricultural Health Study (AHS). We obtained detailed pesticide exposure information from a self-administered questionnaire completed at enrollment (1993-1997). Cancer incidence was followed through January 2002. Over half of cyanazine-exposed applicators had >or=6 years of exposure at enrollment, and approximately 85% had begun using cyanazine before the 1990s. We used adjusted Poisson regression to calculate rate ratios (RRs) and 95% confidence intervals (CIs) of multiple cancer sites among cyanazine-exposed applicators. We calculated ptrend values, and all statistical tests were two-sided. Two exposure metrics were used: tertiles of lifetime days of exposure (LD) and intensity-weighted LD. A total of 20,824 cancer-free AHS applicators reported ever using cyanazine at enrollment. Cancer incidence comparisons between applicators with the lowest cyanazine exposure and those with the highest exposure yielded the following for the LD metric: all cancers, RR=0.99 (95% CI, 0.80-1.24); prostate cancer, RR=1.23 (95% CI, 0.87-1.70); all lymphohematopoietic cancers, RR=0.92 (95% CI, 0.50-1.72); non-Hodgkin lymphoma, RR=1.25 (95% CI, 0.47-3.35); lung cancer, RR=0.52 (95% CI, 0.22-1.25). We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. The number of sites was small for certain cancers, limiting any conclusion with regard to ovarian, breast, and some other cancers. JF - Environmental health perspectives AU - Lynch, Shannon M AU - Rusiecki, Jennifer A AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Lubin, Jay AU - Sandler, Dale AU - Hoppin, Jane A AU - Lynch, Charles F AU - Alavanja, Michael C R AD - Clinical and Genetic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1248 EP - 1252 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Herbicides KW - 0 KW - Triazines KW - cyanazine KW - W34C4P18WD KW - Index Medicus KW - Prostatic Neoplasms -- epidemiology KW - Humans KW - Aged KW - Poisson Distribution KW - Risk Assessment KW - Colonic Neoplasms -- epidemiology KW - Prospective Studies KW - Lung Neoplasms -- epidemiology KW - Lymphoma -- epidemiology KW - Adult KW - Cohort Studies KW - Follow-Up Studies KW - Middle Aged KW - Hematologic Neoplasms -- epidemiology KW - Female KW - Male KW - Herbicides -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Triazines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+cyanazine+in+the+agricultural+health+study.&rft.au=Lynch%2C+Shannon+M%3BRusiecki%2C+Jennifer+A%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay%3BSandler%2C+Dale%3BHoppin%2C+Jane+A%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+C+R&rft.aulast=Lynch&rft.aufirst=Shannon&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2004 Sep 15;96(18):1375-82 [15367570] Occup Environ Med. 2003 Sep;60(9):E11 [12937207] Lancet. 1985 Jun 1;1(8440):1277-8 [2860478] JAMA. 1986 Sep 5;256(9):1141-7 [3801091] Cancer Res. 1987 Nov 1;47(21):5777-81 [3664481] Scand J Work Environ Health. 1989 Feb;15(1):47-53 [2922589] J Environ Sci Health B. 1990 Feb;25(1):1-29 [2187918] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Am J Ind Med. 1990;18(3):295-301 [2220834] Epidemiology. 1993 Jan;4(1):55-62 [8420582] Mutat Res. 1994 Jun;321(4):219-28 [7515160] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Environ Health Perspect. 1997 Nov;105(11):1222-7 [9370519] Environ Res. 1999 Feb;80(2 Pt 1):172-9 [10092410] Am J Epidemiol. 2005 Jan 15;161(2):121-35 [15632262] J Appl Toxicol. 2005 May-Jun;25(3):179-83 [15856525] Arch Environ Contam Toxicol. 2002 Jan;42(1):127-36 [11706377] J Toxicol Environ Health A. 2000 Aug 25;60(8):567-86 [10983523] J Environ Qual. 2001 May-Jun;30(3):831-45 [11401272] Mutat Res. 2001 Jun 27;493(1-2):1-10 [11516710] J Environ Qual. 2001 Nov-Dec;30(6):2120-6 [11790022] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] J Occup Environ Med. 2002 Nov;44(11):1048-58 [12448356] J Toxicol Environ Health A. 2003 Mar 28;66(6):501-17 [12712593] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Occup Environ Med. 2004 Nov;61(11):945-51 [15477289] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phorate exposure and incidence of cancer in the agricultural health study. AN - 68702558; 16882526 AB - We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS). This finding, together with findings of associations between other organophosphate pesticides and cancer more broadly, prompted us to examine phorate exposure and overall cancer incidence in the AHS. Adding 3 years of follow-up and using more detailed exposure information allowed us to see whether the prostate cancer finding held. The AHS is a prospective study of licensed restricted-use pesticide applicators from North Carolina and Iowa. To our knowledge, this is the largest examination of workers occupationally exposed to phorate. Pesticide exposure and other information was collected using two self-administered questionnaires completed from 1993 to 1997. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI), adjusting for potential confounders. Phorate use was not related to the incidence of all cancers combined or to any individual cancer, although we had insufficient numbers to study non-Hodgkin lymphoma or leukemia, which have been linked to organophosphates in other studies. Although prostate cancer risk was not significantly related to phorate use overall or among those without a family history, the risk tended to increase among applicators with a family history of prostate cancer. The interaction RR was 1.53 (95% CI, 0.99-2.37). The observed statistical interaction suggests a gene-environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible. JF - Environmental health perspectives AU - Mahajan, Rajeev AU - Bonner, Matthew R AU - Hoppin, Jane A AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1205 EP - 1209 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Insecticides KW - 0 KW - Phorate KW - 3W54X3W9IV KW - Index Medicus KW - Socioeconomic Factors KW - Zea mays KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - North Carolina -- epidemiology KW - Alcohol Drinking -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Insecticides -- adverse effects KW - Prostatic Neoplasms -- epidemiology KW - Agricultural Workers' Diseases -- epidemiology KW - Phorate -- adverse effects KW - Occupational Exposure -- adverse effects KW - Insecticides -- analysis KW - Phorate -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68702558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Multiresidue+determination+of+sulfonamides+in+edible+catfish%2C+shrimp+and+salmon+tissues+by+high-performance+liquid+chromatography+with+postcolumn+derivatization+and+fluorescence+detection.&rft.au=Gehring%2C+Theresa+A%3BGriffin%2C+Bill%3BWilliams%2C+Rod%3BGeiseker%2C+Charles%3BRushing%2C+Larry+G%3BSiitonen%2C+Paul+H&rft.aulast=Gehring&rft.aufirst=Theresa&rft.date=2006-08-18&rft.volume=840&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Feb 7;143(1):1-118 [10675783] Int Arch Occup Environ Health. 2004 Nov;77(8):559-70 [15688248] Drug Metab Dispos. 2001 Sep;29(9):1201-4 [11502728] J Pharmacol Exp Ther. 2001 Dec;299(3):825-31 [11714865] Int J Occup Med Environ Health. 2001;14(4):339-47 [11885917] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):418-26 [12415490] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Drug Metab Dispos. 2004 Mar;32(3):333-9 [14977868] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Scand J Work Environ Health. 1985 Dec;11(6):397-407 [3912986] Mutat Res. 1986 Aug-Sep;171(2-3):131-8 [3528835] Prostate. 1987;10(1):79-88 [2434937] Mutat Res. 1987 Jul;188(3):241-50 [3600690] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Prostate. 1990;17(4):337-47 [2251225] J Urol. 1991 Nov;146(5):1305-7 [1942282] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] IARC Monogr Eval Carcinog Risks Hum. 1991;53:45-92 [1842588] Am J Epidemiol. 1993 Feb 1;137(3):270-80 [8452135] Arch Environ Health. 1993 Sep-Oct;48(5):353-8 [8215601] J Urol. 1994 Nov;152(5 Pt 1):1484-7; discussion 1487-9 [7933190] J Toxicol Environ Health. 1994 Nov;43(3):271-89 [7966438] Am J Epidemiol. 1995 Apr 15;141(8):732-40 [7535977] Prostate. 1995 Nov;27(5):250-7 [7479392] Br J Urol. 1996 Jan;77(1):6-14 [8653318] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Scand J Work Environ Health. 1996 Aug;22(4):285-93 [8881017] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Urology. 1998 Sep;52(3):441-3 [9730457] J Occup Environ Med. 1999 Apr;41(4):279-88 [10224594] J Toxicol Environ Health B Crit Rev. 1999 Apr-Jun;2(2):161-81 [10230392] Cancer. 1999 Aug 1;86(3):477-83 [10430256] Eur J Cancer. 1999 Feb;35(2):272-7 [10448270] Cancer. 2004 Nov 15;101(10 Suppl):2371-490 [15495199] J Occup Environ Med. 2000 May;42(5):517-25 [10824305] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. AN - 68689331; 16880481 AB - Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression. To examine the relative acute effects of bupropion, sertraline and venlafaxine as adjuncts to mood stabilisers. In a 10-week trial, participants receiving out-patient treatment for bipolar disorder (stratified for rapid cycling) were randomly treated with a flexible dose of one of the antidepressants, or their respective matching placebos, as adjuncts to mood stabilisers. A total of 174 adults with bipolar disorder I, II or not otherwise specified, currently in the depressed phase, were included. All three antidepressants were associated with a similar range of acute response (49-53%) and remission (34-41%). There was a significantly increased risk of switches into hypomania or mania in participants treated with venlafaxine compared with bupropion or sertraline. More caution appears indicated in the use of venlafaxine rather than bupropion or sertraline in the adjunctive treatment of bipolar depression, especially if there is a prior history of rapid cycling. JF - The British journal of psychiatry : the journal of mental science AU - Post, R M AU - Altshuler, L L AU - Leverich, G S AU - Frye, M A AU - Nolen, W A AU - Kupka, R W AU - Suppes, T AU - McElroy, S AU - Keck, P E AU - Denicoff, K D AU - Grunze, H AU - Walden, J AU - Kitchen, C M R AU - Mintz, J AD - Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA. postr@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 124 EP - 131 VL - 189 SN - 0007-1250, 0007-1250 KW - Adjuvants, Pharmaceutic KW - 0 KW - Antidepressive Agents KW - Antidepressive Agents, Second-Generation KW - Cyclohexanols KW - Bupropion KW - 01ZG3TPX31 KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Severity of Illness Index KW - Adjuvants, Pharmaceutic -- adverse effects KW - Double-Blind Method KW - Depressive Disorder -- chemically induced KW - Humans KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Affect KW - Female KW - Male KW - Bipolar Disorder -- drug therapy KW - Bupropion -- adverse effects KW - Bipolar Disorder -- psychology KW - Sertraline -- adverse effects KW - Antidepressive Agents -- adverse effects KW - Cyclohexanols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.atitle=Mood+switch+in+bipolar+depression%3A+comparison+of+adjunctive+venlafaxine%2C+bupropion+and+sertraline.&rft.au=Post%2C+R+M%3BAltshuler%2C+L+L%3BLeverich%2C+G+S%3BFrye%2C+M+A%3BNolen%2C+W+A%3BKupka%2C+R+W%3BSuppes%2C+T%3BMcElroy%2C+S%3BKeck%2C+P+E%3BDenicoff%2C+K+D%3BGrunze%2C+H%3BWalden%2C+J%3BKitchen%2C+C+M+R%3BMintz%2C+J&rft.aulast=Post&rft.aufirst=R&rft.date=2006-08-01&rft.volume=189&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.issn=00071250&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Br J Psychiatry. 2006 Dec;189:569 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trends in cancer risk among people with AIDS in the United States 1980-2002. AN - 68671987; 16868446 AB - People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends. AIDS and cancer registries in 11 US regions (1980-2002) were used to identify cancers in 375 933 people with AIDS. Cancer risk relative to the general population was measured using the standardized incidence ratio (SIR), focusing on the 2 years after AIDS onset for those with AIDS in 1990-1995 and 1996-2002 (HAART era). Time trends were assessed with Poisson regression. Between 1990-1995 and 1996-2002, risk declined for the two major AIDS-defining cancers: Kaposi sarcoma [(KS) n = 5131; SIR, 22 100 and 3640, respectively; P < 0.0001] and non-Hodgkin lymphoma [(NHL) n = 3412; SIR, 53.2 and 22.6, respectively; P < 0.0001]. Declines began in the 1980s, but risk fell sharply in 1996 and was stable thereafter. Risk of cervical cancer did not change (n = 64; SIR, 4.2 and 5.3, respectively; P = 0.33). Among non-AIDS malignancies, lung cancer was most common, but risk declined between 1990-1995 and 1996-2002 (n = 344; SIR, 3.3 and 2.6, respectively; P = 0.02). Risk of Hodgkin lymphoma increased substantially over the 1990-2002 period (n = 149; SIR, 8.1 and 13.6, respectively; P = 0.003). Dramatic declines in KS and NHL were temporally related to improving therapies, especially introduction of HAART, but those with AIDS remain at marked risk. Among non-AIDS-related cancers, a recent increase in Hodgkin lymphoma was observed. JF - AIDS (London, England) AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Goedert, James J AU - Virgo, Phillip AU - McNeel, Timothy S AU - Scoppa, Steven M AU - Biggar, Robert J AU - HIV/AIDS Cancer Match Study AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. engelse@exchange.nih.gov ; HIV/AIDS Cancer Match Study Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1645 EP - 1654 VL - 20 IS - 12 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Lung Neoplasms -- complications KW - Uterine Cervical Neoplasms -- complications KW - Humans KW - Lung Neoplasms -- immunology KW - Hodgkin Disease -- immunology KW - Lymphoma, Non-Hodgkin -- immunology KW - Hodgkin Disease -- epidemiology KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lung Neoplasms -- epidemiology KW - Adult KW - Kidney Neoplasms -- complications KW - Adolescent KW - Sarcoma, Kaposi -- immunology KW - Male KW - Lymphoma, Non-Hodgkin -- complications KW - Kidney Neoplasms -- epidemiology KW - Sarcoma, Kaposi -- epidemiology KW - Sarcoma, Kaposi -- complications KW - Hodgkin Disease -- complications KW - Age Distribution KW - Uterine Cervical Neoplasms -- epidemiology KW - Risk Factors KW - Incidence KW - Middle Aged KW - Uterine Cervical Neoplasms -- immunology KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Kidney Neoplasms -- immunology KW - Acquired Immunodeficiency Syndrome -- complications KW - Neoplasms -- complications KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68671987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Trends+in+cancer+risk+among+people+with+AIDS+in+the+United+States+1980-2002.&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BGoedert%2C+James+J%3BVirgo%2C+Phillip%3BMcNeel%2C+Timothy+S%3BScoppa%2C+Steven+M%3BBiggar%2C+Robert+J%3BHIV%2FAIDS+Cancer+Match+Study&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2006-08-01&rft.volume=20&rft.issue=12&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of surface wipe media for sampling lead on hands. AN - 68666968; 16862713 AB - Hand contamination by toxic agents such as lead presents a potentially significant health hazard to workers if the contamination is transferred to the mouth by food, smoking, or touching the mouth. One method to sample the mass of contamination on hands is to wipe the skin and analyze the wipe media for the analyte. Several commercially available, prewetted wipe media were evaluated and compared. The Palintest and Wash'n Dri media are made of cellulose fiber; the Ghost wipe is made of a nonwoven polyvinyl alcohol fiber. ASTM test method E1792 for surface lead sampling provides some specified minimum requirements and some general, nonspecific criteria that these media should meet. However, no objective determination of the performance or characteristics of these different wiping media were found in the open literature for sampling lead on hands, particularly relating to typical collection efficiency. To test the recovery of lead oxide dust collected from two hands, two different loading levels were used for each wipe medium. Four successive wipes were collected and analyzed individually. The results of this study indicate that only about 52-62% of the total lead loading is recovered with the first wipe, but that up to 75% recovery could be obtained by combining all three successive wipes. This study also describes testing several physical aspects of these wipes that included tensile strength, wetness, and drying rate, which are characteristics that are not specified by ASTM E1792. The results indicate a higher fragility among the cellulosic wipes, less moisture content, and higher drying rates than the Ghost wipe. This information should be helpful when selecting a wipe material that is best suited for an environmental or industrial hygiene surface or skin sampling task and might also be useful for improving such media in the future. JF - Journal of occupational and environmental hygiene AU - Boeniger, Mark AD - National Institute for Occupational Safety and Health, 8380 Jakaro Drive, Cincinnati, OH 45255, USA. mfboeniger@worldnet.att.net Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 428 EP - 434 VL - 3 IS - 8 SN - 1545-9624, 1545-9624 KW - Air Pollutants KW - 0 KW - Dust KW - Oxides KW - Lead KW - 2P299V784P KW - lead oxide KW - 4IN6FN8492 KW - Index Medicus KW - Humans KW - Textiles -- analysis KW - Oxides -- analysis KW - Dust -- analysis KW - Hand KW - Air Pollutants -- analysis KW - Lead -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68666968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=A+comparison+of+surface+wipe+media+for+sampling+lead+on+hands.&rft.au=Boeniger%2C+Mark&rft.aulast=Boeniger&rft.aufirst=Mark&rft.date=2006-08-01&rft.volume=3&rft.issue=8&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited commentary: on the road to improved exposure assessment using geographic information systems. AN - 68655124; 16707652 JF - American journal of epidemiology AU - Ward, Mary H AU - Wartenberg, Daniel AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. wardm@exchange.nih.gov Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 208 EP - 211 VL - 164 IS - 3 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Risk Assessment KW - Epidemiologic Methods KW - Environmental Exposure -- analysis KW - Geographic Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68655124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+on+the+road+to+improved+exposure+assessment+using+geographic+information+systems.&rft.au=Ward%2C+Mary+H%3BWartenberg%2C+Daniel&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-08-01&rft.volume=164&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2006 Aug 1;164(3):200-7 [16754633] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The frequency of workplace exacerbation among health maintenance organisation members with asthma. AN - 68652559; 16601014 AB - Workplace conditions can potentially contribute to the worsening of asthma, yet it is unclear what percentage of adults with asthma experience workplace exacerbation of symptoms. The objective of this investigation was to determine the prevalence of workplace exacerbation of asthma (WEA). Adults with asthma aged 18-44 were enrolled into the baseline survey of a longitudinal study. Members of a health maintenance organisation were considered candidates for participation if they fulfilled membership, diagnostic, and treatment criteria based on automated review of electronic billing, claims, and pharmacy records. Diagnosis and treatment were confirmed by manual review of medical records. A telephone questionnaire was administered. A work related symptom score was assigned to each participant based on responses to questions about work related asthma symptoms, medication use, and symptom triggers. Blinded to participants' answers to these questions, two researchers independently reviewed the self-reported work histories and assigned exposure ratings. A final exposure score was then calculated. Participants with sufficient evidence for work related symptoms and exposure were classified as having WEA. Of the 598 participants with complete data, 557 (93%) were working, and 136 (23%) fulfilled the criteria for WEA. Those with WEA were more likely to be male and to report that they had been bothered by asthma symptoms during the past seven days. Workplace exacerbation of asthma was common in this study population, occurring in over a fifth of these adults with asthma. Physicians should consider that work can contribute to the exacerbation of symptoms when treating adults with asthma. JF - Occupational and environmental medicine AU - Henneberger, P K AU - Derk, S J AU - Sama, S R AU - Boylstein, R J AU - Hoffman, C D AU - Preusse, P A AU - Rosiello, R A AU - Milton, D K AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health/CDC, Morgantown, WV 26501, USA. pkh0@cdc.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 551 EP - 557 VL - 63 IS - 8 KW - Index Medicus KW - Humans KW - Adult KW - Workplace KW - Bias (Epidemiology) KW - Adolescent KW - Male KW - Female KW - Asthma -- etiology KW - Health Maintenance Organizations KW - Occupational Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68652559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=The+frequency+of+workplace+exacerbation+among+health+maintenance+organisation+members+with+asthma.&rft.au=Henneberger%2C+P+K%3BDerk%2C+S+J%3BSama%2C+S+R%3BBoylstein%2C+R+J%3BHoffman%2C+C+D%3BPreusse%2C+P+A%3BRosiello%2C+R+A%3BMilton%2C+D+K&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2006-08-01&rft.volume=63&rft.issue=8&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1993;22 Suppl 2:S57-64 [8132395] Chest. 1993 Sep;104(3):816-20 [8365294] Med J Aust. 1995 Jan 16;162(2):78-81 [7838030] Chest. 1995 Mar;107(3):634-41 [7874929] Chest. 1995 Oct;108(4):1084-117 [7555124] Chest. 1996 Mar;109(3 Suppl):56S-57S [8598157] Chest. 1996 Mar;109(3):688-96 [8617077] Am J Ind Med. 1998 Jan;33(1):1-10 [9408523] Am J Ind Med. 1998 Feb;33(2):114-22 [9438044] West J Med. 1998 Feb;168(2):98-104 [9499743] J Occup Environ Med. 1998 May;40(5):481-91 [9604186] MMWR CDC Surveill Summ. 1999 Jun 25;48(3):1-20 [10421216] Environ Health. 2003 Aug 7;2(1):10 [12952547] Arch Environ Health. 2003 Dec;58(12):781-8 [15859513] Chest. 1999 Dec;116(6):1780-5 [10593805] Am J Epidemiol. 2001 Sep 1;154(5):477-83 [11532790] Int J Occup Environ Health. 2002 Oct-Dec;8(4):291-6 [12412844] Am J Respir Crit Care Med. 2003 Mar 1;167(5):787-97 [12598220] Occup Environ Med. 2004 Jun;61(6):512-7 [15150390] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Chest. 1987 Oct;92(4):613-7 [2958247] Chest. 1990 Nov;98(5 Suppl):148S-161S [2226002] J Clin Epidemiol. 1992 May;45(5):461-72 [1588352] Eur Respir J. 1994 May;7(5):954-60 [8050554] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bovine kidney tissue/biological fluid correlation for penicillin. AN - 68650896; 16846467 AB - Penicillin is one of the most commonly misused drugs in steers and dairy cows. In the US, at slaughter the tolerance is 50 ng/g in kidney and other edible tissues. If the tolerance is exceeded, the carcass may not be used for human food. A preslaughter test for penicillin in an easily accessible biological fluid is needed to predict if the concentration of penicillin is below tolerance in the kidney before the bovine is slaughtered. In this study, 12 steers were injected three times with the approved dose (7000 IU) of penicillin at 12-h intervals. Blood and urine samples were collected at intervals after the final dose of penicillin. At each sampling point, one kidney biopsy sample was collected by laparoscopic surgery in the live animal. Another kidney sample was collected at slaughter. Correlations between plasma and kidney concentrations and between urine and kidney concentrations were determined. These correlations predict with 95% confidence that 99% of the animals will have kidney tissue below penicillin tolerance when the plasma concentration of penicillin is below 0.4 ng/mL and/or the urine penicillin concentration is below 140 ng/mL. JF - Journal of veterinary pharmacology and therapeutics AU - Chiesa, O A AU - Von Bredow, J AU - Smith, M AU - Heller, D AU - Condon, R AU - Thomas, M H AD - Division of Residue Chemistry, Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708, USA. ochiesa@cvm.fda.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 299 EP - 306 VL - 29 IS - 4 SN - 0140-7783, 0140-7783 KW - Anti-Bacterial Agents KW - 0 KW - Penicillins KW - Index Medicus KW - Urinalysis -- veterinary KW - Animals KW - Blood Chemical Analysis -- veterinary KW - Biopsy -- veterinary KW - Abattoirs KW - Injections, Intramuscular -- veterinary KW - Male KW - Female KW - Penicillins -- pharmacology KW - Kidney -- metabolism KW - Anti-Bacterial Agents -- metabolism KW - Kidney -- pathology KW - Cattle -- urine KW - Drug Residues -- analysis KW - Penicillins -- administration & dosage KW - Cattle -- metabolism KW - Cattle -- blood KW - Penicillins -- metabolism KW - Kidney -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Anti-Bacterial Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68650896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Bovine+kidney+tissue%2Fbiological+fluid+correlation+for+penicillin.&rft.au=Chiesa%2C+O+A%3BVon+Bredow%2C+J%3BSmith%2C+M%3BHeller%2C+D%3BCondon%2C+R%3BThomas%2C+M+H&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-08-01&rft.volume=29&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=01407783&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. AN - 68644202; 16847422 AB - Animal studies suggest that lymphomagenesis can be induced by exposure to carcinogenic aromatic and heterocyclic amines found in diet, cigarette smoke and the environment, but human epidemiologic investigations of these exogenous exposures have yielded conflicting results. As part of our evaluation of the role of aromatic and heterocyclic amines, which are metabolized by N-acetyltransferase (NAT) enzymes, in the etiology of non-Hodgkin lymphoma (NHL), we examined NHL risk in relation to genetic variation in NAT1 and NAT2 and exposure to cigarette smoke and dietary heterocyclic amines and mutagens. We genotyped 10 common single nucleotide polymorphisms (SNPs) in NAT1 and NAT2 among 1136 cases and 922 controls from a population-based case-control study in four geographical areas of the USA. Relative risk of NHL for NAT1 and NAT2 genotypes, NAT2 acetylation phenotype, and exposure to cigarette smoke and dietary heterocyclic amines and mutagens was estimated using odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic regression models. We observed increased risk of NHL among individuals with the NAT1*10/*10 genotype compared with individuals with other NAT1 genotypes (OR = 1.60, 95% CI = 1.04-2.46, P = 0.03). We also observed increased NHL risk in a dose-dependent model among NAT2 intermediate- and rapid-acetylators compared with slow-acetylators, although only the trend was statistically significant (intermediate: OR = 1.18, 95% CI = 0.97-1.44, P = 0.1; rapid: OR = 1.43, 95% CI = 0.97-2.14, P = 0.07; P for linear trend = 0.03). Compared with non-smokers, NHL risk estimates for current cigarette smoking were increased only among NAT2 intermediate/rapid-acetylators (OR = 2.44, 95% CI = 1.15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL. JF - Pharmacogenetics and genomics AU - Morton, Lindsay M AU - Schenk, Maryjean AU - Hein, David W AU - Davis, Scott AU - Zahm, Shelia Hoar AU - Cozen, Wendy AU - Cerhan, James R AU - Hartge, Patricia AU - Welch, Robert AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. mortonli@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 537 EP - 545 VL - 16 IS - 8 SN - 1744-6872, 1744-6872 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Variation KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Genetic+variation+in+N-acetyltransferase+1+%28NAT1%29+and+2+%28NAT2%29+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Morton%2C+Lindsay+M%3BSchenk%2C+Maryjean%3BHein%2C+David+W%3BDavis%2C+Scott%3BZahm%2C+Shelia+Hoar%3BCozen%2C+Wendy%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2006-08-01&rft.volume=16&rft.issue=8&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenet Genomics. 2005 Aug;15(8):535-46 [16006997] Mutat Res. 2005 Jul 1;574(1-2):156-72 [15914214] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Carcinogenesis. 2006 Feb;27(2):293-7 [16113054] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] J Natl Cancer Inst. 1999 Oct 20;91(20):1751-8 [10528026] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2003 Mar;24(3):483-9 [12663508] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Jpn J Cancer Res. 1989 Dec;80(12):1176-8 [2516847] DNA Cell Biol. 1990 Apr;9(3):193-203 [2340091] Carcinogenesis. 1993 Aug;14(8):1633-8 [8353847] Arch Toxicol. 1994;68(2):129-33 [8179482] Blood. 1994 Sep 1;84(5):1361-92 [8068936] Cancer Res. 1995 Nov 15;55(22):5226-9 [7585580] JAMA. 1996 May 1;275(17):1315-21 [8614116] Carcinogenesis. 1996 Oct;17(10):2221-7 [8895492] Carcinogenesis. 1997 May;18(5):975-80 [9163683] Pharmacogenetics. 1998 Feb;8(1):55-66 [9511182] Pharmacogenetics. 1998 Feb;8(1):67-72 [9511183] Leuk Res. 1998 May;22(5):445-52 [9652731] Cancer Epidemiol Biomarkers Prev. 1999 Mar;8(3):233-9 [10090301] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Pol J Pharmacol. 2004 Jul-Aug;56(4):445-9 [15520499] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33 [15824165] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of L-carnitine pretreatment in methamphetamine and 3-nitropropionic acid-induced neurotoxicity. AN - 68150701; 17105904 AB - Adult, male Sprague-Dawley rats were injected with 3-ni-tropropionic acid (3-NPA) at 30 mg/kg or methamphetamine (METH) at 20 mg/kg alone or following pretreatment with L-cartnitine (LC) at 100 mg/kg. Rectal temperature was measured before and 4 h following treatment. Animals were sacrificed at 4 h posttreatment. Monoamine neurotransmitters, dopamine (DA) and serotonin (5-HT), and their metabolites were analyzed in the striatum using high-performance liquid chromatography method coupled with electrochemical detection (HPLC/ED). Transcripts of several genes related to DA metabolism were quantified using real time reverse transciption polymerase chain reaction (RT-PCR). Core temperature decreased significantly after 3-NPA acid and increased in METH-treated rats (P < 0.05). Temperature change at 4 h exhibited a significant LC effect for 3-NPA, preventing hypothermia (P < 0.05) and no effect for METH. Concentration of DA and 5-HT, and their metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), increased significantly in 3-NPA and decreased in METH-treated rats. An increase in DOPAC/DA turnover and serotonin observed after 3-NPA was abolished in LC-/3-NPA-treated rats. In both 3-NPA- and METH-treated rats, LC prevented an increase in DA receptor D(1) gene expression. It appears that carnitine effect preventing hypothermia after 3-NPA treatments may be related not only to its mitochondriotropic actions but also to inhibitory effect on the DA and 5-HT systems activated after the exposure to 3-NPA. The same effect observed at the transcriptional level, at least for the DA receptor D(1), may account for protection against METH toxicity. JF - Annals of the New York Academy of Sciences AU - Binienda, Zbigniew K AU - Przybyla, Beata D AU - Robinson, Bonnie L AU - Salem, Nadia AU - Virmani, Ashraf AU - Amato, Antonino AU - Ali, Syed F AD - Division of Neurotoxicology, HFT-132, FDA/NCTR, Jefferson, AR 72079-9502, USA. zbinienda@nctr.fda.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 74 EP - 83 VL - 1074 SN - 0077-8923, 0077-8923 KW - Antihypertensive Agents KW - 0 KW - Dopamine Agents KW - Nitro Compounds KW - Propionates KW - Vitamin B Complex KW - 12001-76-2 KW - Methamphetamine KW - 44RAL3456C KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Neurotoxicity Syndromes -- therapy KW - Vitamin B Complex -- pharmacology KW - Carnitine -- pharmacology KW - Dopamine Agents -- pharmacology KW - Propionates -- pharmacology KW - Methamphetamine -- pharmacology KW - Nitro Compounds -- pharmacology KW - Antihypertensive Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68150701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+zearalenone+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BAlam%2C+Hamida+Z%3BRorie%2C+James%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-10 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - Overview of Diabetes in Children and Adolescents. A Fact Sheet from the National Diabetes Education Program AN - 62028548; ED496109 AB - Type 1 diabetes in U.S. children and adolescents may be increasing and many more new cases of type 2 diabetes are being reported in young people. Standards of care for managing children with diabetes issued by the American Diabetes Association in January 2005 provide more guidance than previously given. To update primary care providers and their staff members on this rapidly changing area of diabetes care, the National Diabetes Education Program (NDEP) has developed this overview of the current literature. This fact sheet describes type 1 and type 2 diabetes and presents statistics, identifying children with diabetes, treatment strategies, monitoring complications and reducing CVD risk, visiting the health care team, helping children manage diabetes, prevention strategies for type 2 diabetes, and such special issues as family support, transition to independence, diabetes at school, and camps and support groups. The fact sheet also lists resources for further information about diabetes, target goals for blood glucose levels, educational materials, and support programs. [The U.S. Department of Health and Human Services' National Diabetes Education Program (NDEP) is jointly sponsored by the National Institutes of Heath (NIH) and the Centers for Disease Control and Prevention (CDC) with the support of more than 200 partner organizations.] Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 13 PB - National Diabetes Education Program. One Diabetes Way, Bethesda, MD 20814-9692. KW - ERIC, Resources in Education (RIE) KW - Prevention KW - Symptoms (Individual Disorders) KW - Therapy KW - Child Health KW - Identification KW - Children KW - Adolescents KW - Medical Services KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62028548?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Emerging Technologies and the Safety and Health of Working People AN - 58743385; 2007-20604 AB - Changes in technologies have far outpaced our knowledge about the implications of these changes for the quality of working life and for safety and health on the job. This gap in knowledge is one of the 21 priority areas for research under the National Occupational Research Agenda (NORA) -- a framework crafted by the National Institute for Occupational Safety and Health (NIOSH) and its partners to guide research into the next decade. This report was developed under NORA as a foundation for a comprehensive research agenda for investigating and reducing occupational safety and health risks as well as intervention opportunities associated with emerging technologies. Research and development needs identified in the agenda include (1) improved surveillance mechanisms to better track the emergence of technology, (2) accelerated research on safety and health implications of emerging technology, (3) increased research focus on protecting and promoting safety and health in emerging technology fields, and (4) steps to formalize and nurture emerging technology as a distinct field within occupational safety and health. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Aug 2006, 28 pp. AU - Johnson, Barry L AU - Myers, Melvin L Y1 - 2006/08// PY - 2006 DA - August 2006 EP - 28p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Science and technology policy - Technology and technology policy KW - Technological innovations KW - United States - Occupational safety and health administration KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58743385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+Barry+L%3BMyers%2C+Melvin+L&rft.aulast=Johnson&rft.aufirst=Barry&rft.date=2006-08-01&rft.volume=&rft.issue=&rft.spage=28p&rft.isbn=&rft.btitle=Emerging+Technologies+and+the+Safety+and+Health+of+Working+People&rft.title=Emerging+Technologies+and+the+Safety+and+Health+of+Working+People&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2006-136/pdfs/2006-136.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - DHHS (NIOSH) Publication No. 2006-136 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - The Novel Use of 'Asian' as an Ethnic Category in the New Zealand Health Sector AN - 57216386; 200613341 AB - 'Asian' is increasingly used as an ethnic category in the health sector in New Zealand but does not have a 'natural', fixed, uncontested meaning. Two differing constructions of 'Asian' are commonly used in New Zealand. One is racially based & includes only East & Southeast Asian peoples. It is commonly employed in popular discourse & by the media. The other construction includes peoples from East, South & Southeast Asia, but excludes peoples from the Middle East & Central Asia. This construction is recent & unique to New Zealand & is being increasingly operationalised in the health sector. This use for planning & research is problematic. For the health sector, 'Asian' does not differentiate a group of people with shared characteristics in terms of health status or needs. The diversity of the 'Asian' category, with several axes of difference, will result in an averaging of health indicators. This may result in the high health needs of groups within this category being masked or the inappropriate targeting of services. Another major concern is the general lack of acknowledgement of the contestable nature of the 'Asian' category or justification for its use. However, the 'Asian' category provides a political platform to advocate for resources & enable research into the previously ignored health status of the diverse 'Asian' population. Despite its shortcomings, usage of the category is likely to continue in the New Zealand health sector. As such, the sector needs to be aware of the limitations of the category & show greater precision in its use. 1 Table, 2 Figures, 56 References. Adapted from the source document. JF - Ethnicity & Health AU - Rasanathan, Kumanan AU - Craig, David AU - Perkins, Rod AD - Auckland Regional Public Health Service, New Zealand kumananr@yahoo.com Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 211 EP - 227 PB - Taylor & Francis, Abingdon UK VL - 11 IS - 3 SN - 1355-7858, 1355-7858 KW - Ethnicity KW - Asian KW - Indian KW - Chinese KW - New Zealand KW - Asian people KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+dosimetry+and+risk+assessment+of+nanoparticles%3A+evaluating+and+extending+current+models+in+rats+and+humans.&rft.au=Kuempel%2C+E+D%3BTran%2C+C+L%3BCastranova%2C+V%3BBailer%2C+A+J&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2006-09-01&rft.volume=18&rft.issue=10&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - ETHEFR N1 - SubjectsTermNotLitGenreText - New Zealand; Health services; Asian people; Ethnicity DO - http://dx.doi.org/10.1080/13557850600565525 ER - TY - JOUR T1 - Unraveling Cultural Threads: A Qualitative Study of Culture and Ethnic Identity among Urban Southwestern American Indian Youth Parents and Elders AN - 57056374; 200616437 AB - We utilized qualitative methods to explore ethnic & cultural identity among urban Southwestern American Indian youth, parents, & elders. Twenty-four respondents ranging in age from approximately 13 to 90 years were interviewed in focus groups divided by age. Six major themes & seventeen sub-themes related to tribal & pan-American Indian ethnic identity were identified. Two important findings emerging from our study were that common ethnic identity constructs can be validated & new identity constructs discovered through qualitative methods. These & other findings suggest the importance of qualitative methods in better understanding cultural & ethnic identity. Of particular significance was the notion that the most salient & relevant identity constructs can be learned from the voices & perspectives of ethnic identity members themselves across generations, age, tribal groups, gender, & reservation & urban residence. Tables, References. Adapted from the source document. JF - Journal of Child and Family Studies AU - House, Laura E AU - Stiffman, Arlene R AU - Brown, Eddie AD - Substance Abuse & Mental Health Services Administration, Health & Human Services, Organization & Finance Bra laura.house@samhsa.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 393 EP - 407 PB - Springer, Dordrecht The Netherlands VL - 15 IS - 4 SN - 1062-1024, 1062-1024 KW - american indian youth KW - pan-American indian identity KW - ethnic and cultural identity KW - qualitative methods KW - intergenerational contexts KW - American Indian people KW - Cultural identity KW - Ethnic identity KW - Young people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57056374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Unraveling+Cultural+Threads%3A+A+Qualitative+Study+of+Culture+and+Ethnic+Identity+among+Urban+Southwestern+American+Indian+Youth+Parents+and+Elders&rft.au=House%2C+Laura+E%3BStiffman%2C+Arlene+R%3BBrown%2C+Eddie&rft.aulast=House&rft.aufirst=Laura&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-006-9038-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JCFSES N1 - SubjectsTermNotLitGenreText - American Indian people; Ethnic identity; Young people; Cultural identity DO - http://dx.doi.org/10.1007/s10826-006-9038-9 ER - TY - JOUR T1 - A Regulatory View on Adaptive/Flexible Clinical Trial Design AN - 21139613; 11158057 AB - Recently there is growing interest in use of adaptive or flexible designs for development of pharmaceutical products. Statistical methodology has been greatly advanced in the literature. However, there are still some important issues with the methodology and application. In addition, there are many other challenges with these designs, including efficiency of these designs in the entire development program, trial conduct and logistics, the infrastructure of an adaptive trial, the regulatory evaluation of trial results and trial conduct, etc. Up till now, regulatory experience in these designs is very limited. We share some of the challenges. JF - Biometrical Journal AU - Hung, H M James AU - O'Neill, Robert T AU - Wang, Sue-Jane AU - Lawrence, John AD - Division of Biometrics I, OB/OTS/CDER/FDA, Rockville, MD, USA, hsienming.hung@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 565 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Pharmaceuticals KW - Biometrics KW - Clinical trials KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21139613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=A+Regulatory+View+on+Adaptive%2FFlexible+Clinical+Trial+Design&rft.au=Hung%2C+H+M+James%3BO%27Neill%2C+Robert+T%3BWang%2C+Sue-Jane%3BLawrence%2C+John&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Clinical trials; Statistics; Biometrics; Pharmaceuticals DO - http://dx.doi.org/10.1002/bimj.200610229 ER - TY - JOUR T1 - Some Aspects of the Application of Internal Pilot Studies AN - 21125684; 11158054 AB - This is a discussion of the paper' Sample size recalculation in internal pilot study designs' by Tim Friede and Meinhard Kieser, appearing in this special issue on adaptive designs. JF - Biometrical Journal AU - Lachenbruch, Peter A AU - Wittes, Janet AD - US Food and Drug Administration (retired), lachenbruchpa@aol.com Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 556 EP - 557 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Biometrics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21125684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Some+Aspects+of+the+Application+of+Internal+Pilot+Studies&rft.au=Lachenbruch%2C+Peter+A%3BWittes%2C+Janet&rft.aulast=Lachenbruch&rft.aufirst=Peter&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610243 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Biometrics; Statistics DO - http://dx.doi.org/10.1002/bimj.200610243 ER - TY - JOUR T1 - Rejoinder AN - 21089418; 11132871 AB - Abstract not available. JF - Biometrical Journal AU - Hung, H M James AU - O'Neill, Robert T AU - Wang, Sue-Jane AU - Lawrence, John Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 613 EP - 615 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Biometrics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21089418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Rejoinder&rft.au=Hung%2C+H+M+James%3BO%27Neill%2C+Robert+T%3BWang%2C+Sue-Jane%3BLawrence%2C+John&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610258 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Biometrics; Statistics DO - http://dx.doi.org/10.1002/bimj.200610258 ER - TY - JOUR T1 - FDA's Critical Path Initiative: A Perspective on Contributions of Biostatistics AN - 21073740; 11132863 AB - This article describes the motivation for, description of, and the objectives and plans for the FDA's initiative that was introduced in March of 2004 by way of a report titled Innovation or Stagnation? - Challenge and Opportunity on the Critical Path to New Medical Products. The FDA initiative is very much an outreach effort and a wake-up call to many constituencies to contribute and partner to improve the product development process and thereby to contribute to the success rate of new products that will benefit the public. We discuss in general terms where some of the opportunities and challenges exist for the discipline of biostatistics to make contributions to this effort over the next few years. In particular, guidance development in five areas is considered as is the need to devote new energy and efforts to quantitative risk assessment and safety evaluation, an area that has lagged the attention received in the efficacy evaluation area. JF - Biometrical Journal AU - O'Neill, R T AD - Office of Biostatistics, OTS/CDER/FDA, 10903 New Hampshire Avenue, Bldg 22, Room 6012, Silver Spring, MD 20993-0002, USA, oneill@cder.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 559 EP - 564 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Vocalization behavior KW - Motivation KW - Medical equipment KW - Energy KW - Development KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=FDA%27s+Critical+Path+Initiative%3A+A+Perspective+on+Contributions+of+Biostatistics&rft.au=O%27Neill%2C+R+T&rft.aulast=O%27Neill&rft.aufirst=R&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200510237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Development; Risk assessment; Energy; Motivation; Medical equipment; Vocalization behavior DO - http://dx.doi.org/10.1002/bimj.200510237 ER - TY - RPRT T1 - Farmer Crushed Under Falling Dump Trailer Box While Repairing Lift Cylinder AN - 20967543; 11069915 AB - A 64-year-old, part-time farmer was working in the machinery shed on his farm late in the spring of 2004. He was repairing the hydraulic cylinder lift system for the box on a tandem wheel dump trailer. He used a skid steer equipped with a pallet fork attachment to lift and hold the front of the trailer box in a raised position. This provided clearance for the farmer to access the hydraulic cylinder and lift linkage area under the middle of the dump trailer box. The man was working alone in his machine shed at the time of the incident. He had disconnected the hydraulic cylinder from the underside of the trailer box. The skid steer forks reaching in from outside the doorway held the front of the box in an elevated position similar to when a load is being dumped from the wagon box. As he leaned across the frailer frame under the box to remove the hydraulic cylinder, the trailer moved rearward. The front edge of the wagon slipped off the forks of the skid steer and the trailer box fell suddenly. The man was crushed over the lift linkage and frame by the underside of the trailer box. A few moments after the incident a relative discovered the farmer trapped under the wagon's box. Emergency crews were summoned. They used jacks and struts to secure both the wagon and the raised lift arms of the skid steer. Resuscitative efforts were not successful and the farmer was pronounced dead at the scene. RECOMMENDATIONS: Dump trailers should be equipped with rigid mechanical means to secure the trailer box in a raised position and they must be put into place without entering the area under the raised wagon box before making inspections, adjustments, or repairs under a raised box. Persons planning repairs underneath a dump trailer should securely block (chock) the rear axle wheels to prevent unexpected, inadvertent movement of the trailer. Persons inspecting or working on dump trailer lift systems should, when possible, choose to perform the task with the trailer box in its lowest position. Dump trailers should be designed to accommodate, when practicable, service and replacement of the lift system while the trailer box is in its lowest position. JF - Farmer Crushed Under Falling Dump Trailer Box While Repairing Lift Cylinder. [np]. Aug 2006. Y1 - 2006/08// PY - 2006 DA - Aug 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Hydraulics KW - Machinery KW - farms KW - inspection KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2006-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Farmer+Crushed+Under+Falling+Dump+Trailer+Box+While+Repairing+Lift+Cylinder&rft.title=Farmer+Crushed+Under+Falling+Dump+Trailer+Box+While+Repairing+Lift+Cylinder&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F sub(1) mice and F344 rats AN - 20722810; 6930423 AB - Malachite green is a triphenylmethane dye used in the fish industry as an anti-fungal agent. Leucomalachite green is formed by the metabolic reduction of malachite green and persists in the tissues of exposed fish. In this study, we examined the carcinogenicity of malachite green chloride and leucomalachite green. Female F344 rats (48 per group) were fed diets containing 0, 100, 300, or 600 ppm malachite green chloride for 104 weeks, at which time the extent of tumorigenesis was assessed. Additional groups of 48 female and 48 male F344 rats were fed diets containing 0, 91, 272, or 543 ppm leucomalachite green for 104 weeks. Groups of 48 female B6C3F sub(1) mice were fed diets containing 0, 100, 225, or 450 ppm malachite green chloride or 0, 91, 204, or 408 ppm leucomalachite green for 104 weeks. For each of the exposures, food consumption in the treatment groups was similar to the controls. Rats fed malachite green chloride or leucomalachite green had dose-dependent reductions in body weight; in mice, there were no consistent effects upon body weights with either compound. Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma. Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia. In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis. There were no treatment-related neoplasms in female B6C3F sub(1) mice fed malachite green chloride. Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group. JF - Food and Chemical Toxicology AU - Culp, Sandra J AU - Mellick, Paul W AU - Trotter, Ronald W AU - Greenlees, Kevin J AU - Kodell, Ralph L AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States, frederick.beland@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1204 EP - 1212 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 8 SN - 0278-6915, 0278-6915 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Malachite green KW - Leucomalachite green KW - Carcinogenesis KW - Testes KW - Diets KW - Leukocytes (mononuclear) KW - Mammary gland KW - Tumorigenesis KW - Thyroid KW - Chloride KW - Carcinoma KW - Leukemia KW - Food consumption KW - Body weight KW - Pituitary KW - Interstitial cells KW - Carcinogenicity KW - Adenoma KW - Hepatocellular carcinoma KW - K 03410:Animal Diseases KW - X 24135:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Single-laboratory+validation+of+a+method+for+the+determination+of+furan+in+foods+by+using+static+headspace+sampling+and+gas+chromatography%2Fmass+spectrometry.&rft.au=Nyman%2C+Patricia+J%3BMorehouse%2C+Kim+M%3BMcNeal%2C+Timothy+P%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Testes; Leukocytes (mononuclear); Mammary gland; Tumorigenesis; Thyroid; Chloride; Carcinoma; Food consumption; Leukemia; Body weight; Carcinogenicity; Interstitial cells; Pituitary; Adenoma; Hepatocellular carcinoma DO - http://dx.doi.org/10.1016/j.fct.2006.01.016 ER - TY - JOUR T1 - Adjuvant Activity of CpG Oligodeoxynucleotides AN - 20559215; 8071186 AB - Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Th1 and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5- to 500-fold. The CpG motifs present in bacterial DNA plasmids may contribute to the immunogenicity of DNA vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans and can improve vaccine-induced immune responses. JF - International Reviews of Immunology AU - Klinman, Dennis M AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 135 EP - 154 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3-4 SN - 0883-0185, 0883-0185 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphocytes B KW - Helper cells KW - Adjuvants KW - CpG islands KW - Plasmids KW - Oligonucleotides KW - Cell activation KW - Inflammation KW - Dendritic cells KW - DNA vaccines KW - Immunogenicity KW - Lymphocytes T KW - Cytokines KW - Vaccines KW - Antigen-presenting cells KW - Immune response KW - F 06905:Vaccines KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Separate+Pathways+for+O+Acetylation+of+Polymeric+and+Monomeric+Sialic+Acids+and+Identification+of+Sialyl+O-Acetyl+Esterase+in+Escherichia+coli+K1&rft.au=Steenbergen%2C+Susan+M%3BLee%2C+Young-Choon%3BVann%2C+Willie+F%3BVionnet%2C+Justine%3BWright%2C+Lori+F%3BVimr%2C+Eric+R&rft.aulast=Steenbergen&rft.aufirst=Susan&rft.date=2006-09-01&rft.volume=188&rft.issue=17&rft.spage=6195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Helper cells; CpG islands; Adjuvants; Plasmids; Oligonucleotides; Inflammation; Cell activation; Dendritic cells; DNA vaccines; Immunogenicity; Lymphocytes T; Cytokines; Immune response; Antigen-presenting cells; Vaccines DO - http://dx.doi.org/10.1080/08830180600743057 ER - TY - JOUR T1 - Human infections with Fusobacterium necrophorum AN - 20517617; 9203177 AB - Fusobacterium necrophorum is a Gram-negative anaerobic bacillus that can be a primary pathogen causing either localised abscesses and throat infections or systemic life-threatening disease. Systemic infections due to F. necrophorum are referred to as either Lemierre's disease/syndrome, post-anginal sepsis or necrobacillosis, but in the context of this mini-review, all are included under the umbrella term of 'invasive F. necrophorum disease' (IFND). Although IFND has been well documented for over a century, it is quite a rare condition and modern-day clinicians of various medical disciplines are frequently unaware of this organism and the severity of symptoms that it can cause. IFND classically occurs in previously healthy young people although the factors that trigger the invasive process are not fully understood. There are countless descriptive case histories and small series of cases of IFND disease in the literature and although commonly referred to as a forgotten' disease, in truth, it is probably best described as a repeatedly 'discovered' disease, as it may not always be included in medical curricula, and neither is it mentioned in some major medical textbooks. There is some evidence that IFND may be on the increase, particularly in the UK. The potential reasons for this are considered in this review along with an historical overview, and updates on disease incidence, patient demography, pathogenesis and laboratory diagnosis. JF - Anaerobe AU - Brazier, J S AD - Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 165 EP - 172 VL - 12 IS - 4 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Demography KW - Sepsis KW - Pharynx KW - Reviews KW - Disseminated infection KW - Fusobacterium necrophorum KW - Pathogens KW - Abscesses KW - Bacillus KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20517617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Human+infections+with+Fusobacterium+necrophorum&rft.au=Brazier%2C+J+S&rft.aulast=Brazier&rft.aufirst=J&rft.date=2006-08-01&rft.volume=12&rft.issue=4&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2005.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; Sepsis; Pharynx; Reviews; Disseminated infection; Pathogens; Abscesses; Fusobacterium necrophorum; Bacillus DO - http://dx.doi.org/10.1016/j.anaerobe.2005.11.003 ER - TY - JOUR T1 - Calpain Activation in Apoptosis of Motoneurons in Cell Culture Models of Experimental Parkinsonism AN - 20243330; 7165285 AB - Parkinson's disease (PD) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (SN). The present study briefly describes our findings to support the hypothesis that there is a possibility of degeneration of spinal cord (SC) motoneurons in course of parkinsonism. In cell culture models of experimental parkinsonism, we examined the degeneration of ventral SC motoneuron cell line (VSC4.1) following exposure to two different toxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone. Our studies suggested calpain activation in the apoptosis of VSC4.1 motoneurons due to exposure to these parkinsonian toxins. Furthermore, our study showed the toxic effects of the dopaminergic toxin methamphetamine (METH) on VSC4.1 cells. The results strongly implicated a possible role for calpain in the mechanism of motoneuron apoptosis during parkinsonian degeneration, at large. Hence, we examined the neuroprotective efficacy of calpeptin, a specific inhibitor of calpain, in cell culture model of experimental parkinsonism. JF - Annals of the New York Academy of Sciences AU - Samantaray, Supriti AU - Ray, Swapan K AU - Ali, Syed F AU - Banik, Naren L AD - Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research-FDA, Jefferson, Arkansas 72079, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 349 EP - 356 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1074 SN - 0077-8923, 0077-8923 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts; CSA Neurosciences Abstracts KW - Substantia nigra KW - Apoptosis KW - Spinal cord KW - MPTP KW - Parkinson's disease KW - Neuroprotection KW - Cell culture KW - Toxins KW - Neurodegenerative diseases KW - Motor neurons KW - Methamphetamine KW - Dopamine KW - Movement disorders KW - Rotenone KW - Neurons KW - Central nervous system diseases KW - Calpain KW - Degeneration KW - Basal ganglia KW - T 2000:Cellular Calcium KW - W 30945:Fermentation & Cell Culture KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Calpain+Activation+in+Apoptosis+of+Motoneurons+in+Cell+Culture+Models+of+Experimental+Parkinsonism&rft.au=Samantaray%2C+Supriti%3BRay%2C+Swapan+K%3BAli%2C+Syed+F%3BBanik%2C+Naren+L&rft.aulast=Samantaray&rft.aufirst=Supriti&rft.date=2006-08-01&rft.volume=1074&rft.issue=&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Substantia nigra; Apoptosis; MPTP; Spinal cord; Parkinson's disease; Cell culture; Neuroprotection; Toxins; Motor neurons; Neurodegenerative diseases; Methamphetamine; Movement disorders; Dopamine; Rotenone; Neurons; Central nervous system diseases; Calpain; Degeneration; Basal ganglia ER - TY - JOUR T1 - Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis AN - 20232871; 7131045 AB - Tamoxifen is a non-steroidal anti-estrogen used for the treatment of breast cancer and, more recently, as a chemopreventive agent in healthy women at high risk of developing breast cancer. On the other hand, tamoxifen is a potent hepatocarcinogen in rats, with both tumor-initiating and tumor-promoting properties. There is substantial evidence that hepatic tumors in rats are initiated as a result of formation of tamoxifen-DNA adducts; however, events subsequent to DNA adduct formation are not clear. Recently, it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations. In the current study, we investigated whether or not the mechanism of tamoxifen-induced hepatocarcinogenesis includes both genotoxic and epigenetic components. Female Fisher 344 rats were fed a 420 p.p.m. tamoxifen diet for 6, 12, 18 or 24 weeks. Hepatic tamoxifen-DNA adduct levels, as assessed by high-performance liquid chromatography and electrospray tandem mass spectrometry, were 580 adducts/10 super(8) nt at 6 weeks, and increased to similar to 1700 adducts/10 super(8) nt by 18 weeks. Global liver DNA hypomethylation, as determined by an HpaII-based cytosine extension assay, was increased at all time points, with the maximum increase ( similar to 200%) occurring at 6 weeks. Protein expressions of maintenance (DNMT1) DNA methyltransferase and de novo DNA methyltransferases DNMT3a and DNMT3b were decreased at all time points. Likewise, trimethylation of histone H4 lysine 20 was significantly decreased at all time points. In contrast, non-target tissues (i.e. mammary gland, pancreas and spleen) did not show any changes in global DNA methylation or DNA methyltransferase activity. These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis. JF - Carcinogenesis AU - Tryndyak, Volodymyr P AU - Muskhelishvili, Levan AU - Kovalchuk, Olga AU - Rodriguez-Juarez, Rocio AU - Montgomery, Beverly AU - Churchwell, Mona I AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research Jefferson, AR 72079, USA. Toxicologic Pathology Associates, National Center for Toxicological Research Jefferson, AR 72079, USA. Department of Biological Sciences, University of Lethbridge AB T1K 3M4, Canada. Division of Cancer Prevention, National Cancer Institute Bethesda, MD 20892, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1713 EP - 1720 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Genetics Abstracts KW - High-performance liquid chromatography KW - Risk assessment KW - Pancreas KW - Lysine KW - Carcinogens KW - Mass spectroscopy KW - Cytosine KW - Histone H4 KW - epigenetics KW - Risk factors KW - DNA methylation KW - DNA methyltransferase KW - chemopreventive agents KW - Diets KW - DNA adducts KW - Etiology KW - Data processing KW - Mammary gland KW - DNMT1 protein KW - Genotoxicity KW - Spleen KW - Tumors KW - Tamoxifen KW - Carcinogenesis KW - Liver KW - Breast cancer KW - Proteins KW - Methylation KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20232871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Effect+of+long-term+tamoxifen+exposure+on+genotoxic+and+epigenetic+changes+in+rat+liver%3A+implications+for+tamoxifen-induced+hepatocarcinogenesis&rft.au=Tryndyak%2C+Volodymyr+P%3BMuskhelishvili%2C+Levan%3BKovalchuk%2C+Olga%3BRodriguez-Juarez%2C+Rocio%3BMontgomery%2C+Beverly%3BChurchwell%2C+Mona+I%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1713&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; High-performance liquid chromatography; Pancreas; Lysine; Carcinogens; Mass spectroscopy; Cytosine; Histone H4; epigenetics; Risk factors; DNA methylation; chemopreventive agents; DNA methyltransferase; Diets; DNA adducts; Etiology; Data processing; DNMT1 protein; Mammary gland; Genotoxicity; Spleen; Tumors; Tamoxifen; Carcinogenesis; Liver; Proteins; Breast cancer; Methylation ER - TY - JOUR T1 - Occurrence of Vibrio parahaemolyticus in Fishery Products from the Southwestern Coast of Korea AN - 19987372; 7223231 AB - Fishery products were collected in seafood markets located on the southwestern coast of Korea between 2000 and 2004 and examined for the presence of Vibrio parahaemolyticus. This strain was detected in 138 of 843 samples (16.4%) that included clams, eels, crabs, octopuses, and cockles. The number of positive findings for V. parahaemolyticus among fishery products was the highest in clams at 23.6% followed by eels at 22.1%, crabs at 21.1%, octopuses at 18.0%, and cockles at 14.3%. V. parahaemolyticus was detected with overall frequencies of 15.3, 14.8, 13.8, 21.6, and 18.6% from 2000 to 2004, respectively. The monthly occurrence of the organism rapidly increased to over 20% between June and October. The monthly cases of food borne disease caused by V. parahaemolyticus in Korea over the last five years began to increase in August and reached its peak in September. However, the potential for outbreaks of food borne disease caused by V. parahaemolyticus was relatively minor between November and April. Consequently, this study shows that fishery products harvested from June to October must be handled sanitarily in Korea. JF - Food Science and Biotechnology AU - Yoon, CY AU - Kang, K J AD - Korea Food and Drug Administration, Gwangju Regional KFDA, Gwangju 500-480, Korea, kjkang@kfda.go.kr Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 578 EP - 581 VL - 15 IS - 4 SN - 1226-7708, 1226-7708 KW - Crabs KW - Crayfishes KW - Lobsters KW - Prawns KW - Shrimp KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Decapoda KW - Vibrio parahaemolyticus KW - Food KW - Seafood KW - Fishery products KW - Coasts KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19987372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Science+and+Biotechnology&rft.atitle=Occurrence+of+Vibrio+parahaemolyticus+in+Fishery+Products+from+the+Southwestern+Coast+of+Korea&rft.au=Yoon%2C+CY%3BKang%2C+K+J&rft.aulast=Yoon&rft.aufirst=CY&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Food+Science+and+Biotechnology&rft.issn=12267708&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Food; Seafood; Coasts; Fishery products; Decapoda; Vibrio parahaemolyticus ER - TY - JOUR T1 - Sequencing of the intergenic 16S-23S rRNA spacer (ITS) region of Mollicutes species and their identification using microarray-based assay and DNA sequencing AN - 19974062; 7242833 AB - We have completed sequencing the 16S-23S rRNA intergenic transcribed spacer (ITS) region of most known Mycoplasma, Acholeplasma, Ureaplasma, Mesoplasma, and Spiroplasma species. Analysis of the sequence data revealed a significant interspecies variability and low intraspecies polymorphism of the ITS region among Mollicutes. This finding enabled the application of a combined polymerase chain reaction-microarray technology for identifying Mollicutes species. The microarray included individual species-specific oligonucleotide probes for characterizing human Mollicutes species and other species known to be common cell line contaminants. Evaluation of the microarray was conducted using multiple, previously characterized, Mollicutes species. The microarray analysis of the samples used demonstrated a highly specific assay, which is capable of rapid and accurate discrimination among Mollicutes species. JF - Applied Microbiology and Biotechnology AU - Volokhov, Dmitriy V AU - George, Joseph AU - Liu, Sue X AU - Ikonomi, Pranvera AU - Anderson, Christine AU - Chizhikov, Vladimir AD - US Food and Drug Administration, HFM-470, 1401 Rockville Pike, Rockville, MD, 20852, USA, volokhov@cber.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 680 EP - 698 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 71 IS - 5 SN - 0175-7598, 0175-7598 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Mollicutes KW - Data processing KW - DNA probes KW - Acholeplasma KW - Probes KW - Spacer KW - DNA microarrays KW - Oligonucleotides KW - rRNA KW - DNA sequencing KW - Ureaplasma KW - Spiroplasma KW - Contaminants KW - Mycoplasma KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Sequencing+of+the+intergenic+16S-23S+rRNA+spacer+%28ITS%29+region+of+Mollicutes+species+and+their+identification+using+microarray-based+assay+and+DNA+sequencing&rft.au=Volokhov%2C+Dmitriy+V%3BGeorge%2C+Joseph%3BLiu%2C+Sue+X%3BIkonomi%2C+Pranvera%3BAnderson%2C+Christine%3BChizhikov%2C+Vladimir&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2006-08-01&rft.volume=71&rft.issue=5&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-005-0280-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - rRNA; DNA sequencing; Data processing; DNA probes; Probes; Spacer; Contaminants; Oligonucleotides; DNA microarrays; Mollicutes; Ureaplasma; Spiroplasma; Acholeplasma; Mycoplasma DO - http://dx.doi.org/10.1007/s00253-005-0280-7 ER - TY - JOUR T1 - Immunization to Protect the US Armed Forces: Heritage, Current Practice, and Prospects AN - 19852686; 7128186 AB - Americans serving with the US Armed Forces need protection from the dangerous infections that they can contract during training, based on occupation, during overseas deployment, or because of underlying health status. For over 230 years, the military health-care system has immunized troops to protect them personally and to help them accomplish their missions. Military researchers have invented, developed, and improved vaccines and immunization delivery methods against more than 20 diseases. This article consolidates content from several previous historical reviews, adds additional sources, and cites primary literature regarding military contributions and accomplishments. Discussion emphasizes smallpox, typhoid fever, tetanus, influenza, meningococcal disease, adenovirus, yellow fever, pneumococcal disease, and anthrax. Delivery issues include documentation, simultaneous immunization, seroscreening, safety surveillance, jet injection, and cold-chain management. Immunization policies for each major US conflict are described. Military immunization programs need to be individualized on the basis of personal contraindications and prior immunity. The proper conduct of military immunization programs respects the need for detailed education of military personnel, maximizes quality in immunization delivery, and supports quality clinical care to prevent and treat adverse events after immunization. Military immunization programs maintain the health of soldiers, marines, sailors, airmen, and coast guardsmen, the resources most critical to military success. JF - Epidemiologic Reviews AU - Grabenstein, John D AU - Pittman, Phillip R AU - Greenwood, John T AU - Engler, Renata JM AD - Office of the Surgeon General, US Army, Falls Church, VA. US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD. Allergy-Immunology Department, Vaccine Healthcare Centers Network, Walter Reed Army Medical Center, Washington, DC Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 3 EP - 26 PB - Johns Hopkins University, School of Hygiene & Public Health, Candler Bldg., Ste. 840 111 Market Place Baltimore MD 21202-6709 USA VL - 28 IS - 1 SN - 0193-936X, 0193-936X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Historical account KW - vaccines KW - meningococcal disease KW - Neisseria meningitidis KW - anthrax KW - Infection KW - Tetanus KW - immunization KW - Influenza KW - Yellow fever KW - infection KW - Anthrax KW - Military KW - Typhoid fever KW - Coasts KW - Training KW - Adenovirus KW - Immunity KW - Immunization KW - Smallpox KW - USA KW - Streptococcus pneumoniae KW - Education KW - Reviews KW - Soldiers KW - Vaccines KW - Military personnel KW - Occupational health KW - V 22350:Immunology KW - J 02350:Immunology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19852686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+Performance+of+Three+Different+Types+of+Respiratory+Protection+Devices&rft.au=Lawrence%2C+R+B%3BDuling%2C+M+G%3BCalvert%2C+CA%3BCoffey%2C+C+C&rft.aulast=Lawrence&rft.aufirst=R&rft.date=2006-09-01&rft.volume=3&rft.issue=9&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600829211 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Historical account; meningococcal disease; Immunity; Tetanus; Infection; Immunization; Smallpox; Influenza; Yellow fever; Reviews; Soldiers; Anthrax; Vaccines; Typhoid fever; Military personnel; Coasts; immunization; vaccines; Education; Training; infection; anthrax; Military; Occupational health; Streptococcus pneumoniae; Adenovirus; Neisseria meningitidis; USA ER - TY - JOUR T1 - Intratumoral Therapy with IL13-PE38 Results in Effective CTL-Mediated Suppression of IL-13R alpha 2-Expressing Contralateral Tumors AN - 19850245; 7131201 AB - PURPOSE: IL13-PE38, a targeted cytotoxin comprised of interleukin 13 (IL-13) and a mutated form of Pseudomonas exotoxin, induces specific killing of tumor cells expressing abundant levels of the IL-13R alpha 2 chain. We hypothesized that tumor cells killed by the cytotoxin may release antigens and/or apoptotic bodies when cells are dying, which then induce adoptive immunity, and that the PE38 portion of IL13-PE38 may act as a stimulant for the induction of a CTL response. Experimental Design: To test this hypothesis, we established D5 melanoma tumors with or without expression of the IL-13R alpha 2 chain in both flanks of C57BL/6 mice, and then IL13-PE38 was injected in the right flank tumors only. RESULTS: and Conclusions: When animals with IL-13R alpha 2-expressing D5 tumor (right) were injected with IL13-PE38, right flank tumors expressing the IL-13R alpha 2 chain not only showed dramatic regression but contralateral tumors (left flank) also showed tumor regression. Cell depletion experiments in tumor-bearing animals indicated that both CD8 super(+) and CD4 super(+) T cells contribute to the regression of contralateral tumors through CTL activation in the periphery and cellular infiltration into tumors. In addition, intratumoral treatment into s.c. tumors of mice bearing metastatic lung tumors with IL13-PE38 showed not only the reduction of treated s.c. tumor but also the reduction of lung metastasis. Thus, IL13-PE38 mediates an antitumor effect not only directly but also indirectly by inducing a host CD8 super(+) T cell immune response. Accordingly, targeted cytotoxins may be used to treat local disease even if they cannot be administered systemically, and yet may still induce a reasonable systemic antitumor response. JF - Clinical Cancer Research AU - Kawakami, Koji AU - Terabe, Masaki AU - Kioi, Mitomu AU - Berzofsky, Jay A AU - Puri, Raj K AD - Authors' Affiliations: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville Pike, Rockville Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 4678 EP - 4686 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 15 SN - 1078-0432, 1078-0432 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Cytotoxins KW - Interleukin 1 KW - Pseudomonas KW - Stimulants KW - CD8 antigen KW - Tumors KW - Immunity KW - Tumor cells KW - Exotoxins KW - Cell activation KW - Melanoma KW - Metastases KW - CD4 antigen KW - Cytotoxicity KW - Interleukin 13 KW - Lung KW - Lymphocytes T KW - Antitumor activity KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Intratumoral+Therapy+with+IL13-PE38+Results+in+Effective+CTL-Mediated+Suppression+of+IL-13R+alpha+2-Expressing+Contralateral+Tumors&rft.au=Kawakami%2C+Koji%3BTerabe%2C+Masaki%3BKioi%2C+Mitomu%3BBerzofsky%2C+Jay+A%3BPuri%2C+Raj+K&rft.aulast=Kawakami&rft.aufirst=Koji&rft.date=2006-08-01&rft.volume=12&rft.issue=15&rft.spage=4678&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Cytotoxins; Interleukin 1; Stimulants; Immunity; Tumors; CD8 antigen; Tumor cells; Exotoxins; Melanoma; Cell activation; Metastases; Interleukin 13; Cytotoxicity; CD4 antigen; Lung; Lymphocytes T; Antitumor activity; Pseudomonas ER - TY - JOUR T1 - Optimization of extrusion conditions for elimination of mesophilic bacteria during thermal processing of animal feed mash AN - 19839251; 6965338 AB - Salmonella and other pathogenic organisms that infect poultry and other livestock can originate from feed and environmental sources. Thus, measures are taken to control Salmonella infection in animals to improve food safety and reduce production losses. The current study was designed to investigate and optimize extrusion conditions for reducing bacterial counts in a surrogate feed matrix. A single-screw extruder was used to process feed artificially inoculated with Bacillus stearothermophilus 12980 (ATCC, Reston, Virginia). Preliminary experiments demonstrated that Salmonella typhimurium (S. typhimurium NAL super(r)) was eliminated from feed under conditions of moderate extrusion stringency (285 g moisture/kg mash feed, 83 degree C extruder barrel exit temperature, 7 s retention time in the extruder barrel) and, therefore, a more thermotolerant organism was required to conduct the study. Spores of B. stearothermophilus 12980 inoculated into a surrogate feed matrix consisting of 600 g maize meal/kg, 300 g soya bean meal/kg and 100 g animal protein blend/kg, respectively, was used to investigate the effect of three extrusion variables on microbial killing. The three variables were extruder barrel exit temperature (T), mash feed moisture content (M sub(c)), and mean retention time of feed in the extruder barrel (R sub(t)). A rotatable central composite statistical design was used with three independent variables and five levels each. The quadratic response surface model fit to spore count data was used to predict extrusion conditions that maximized bacterial killing. The response surface indicated a stationary point within the design region that was a saddle. An estimated ridge of maximum killing indicated that a maximum reduction of 1.03 log cycles would occur under the following extruder settings: T = 110 degree C, M sub(c) = 245 g/kg and R sub(t) = 11 s. Because the moderate stringency condition (T = 83 degree C, M sub(c) = 285 g/kg and R sub(t) = 7 s) completely eliminated detectable S. typhimurium in the test feed matrix, it would appear that all S. typhimurium cells and all mesophilic organisms of similar thermal tolerance would be eliminated at most extruder conditions within the central composite design region. JF - Animal Feed Science and Technology AU - Okelo, PO AU - Wagner, D D AU - Carr, LE AU - Wheaton, F W AU - Douglass, L W AU - Joseph, S W AD - Center for Veterinary Medicine, US Food and Drug Administration, Rockville, MD 20855, United States, Phares.Okelo@fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 116 EP - 137 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 129 IS - 1-2 SN - 0377-8401, 0377-8401 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella typhimurium KW - Bacillus stearothermophilus KW - Bacteria KW - Feeds KW - Extrusion KW - Mash KW - Thermal processing KW - Temperature effects KW - Mesophilic bacteria KW - Poultry KW - Statistics KW - Data processing KW - Food KW - Temperature requirements KW - Infection KW - Beans KW - Livestock KW - Zea mays KW - Food sources KW - Spores KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Animal+Feed+Science+and+Technology&rft.atitle=Optimization+of+extrusion+conditions+for+elimination+of+mesophilic+bacteria+during+thermal+processing+of+animal+feed+mash&rft.au=Okelo%2C+PO%3BWagner%2C+D+D%3BCarr%2C+LE%3BWheaton%2C+F+W%3BDouglass%2C+L+W%3BJoseph%2C+S+W&rft.aulast=Okelo&rft.aufirst=PO&rft.date=2006-08-01&rft.volume=129&rft.issue=1-2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Animal+Feed+Science+and+Technology&rft.issn=03778401&rft_id=info:doi/10.1016%2Fj.anifeedsci.2005.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Mesophilic bacteria; Poultry; Data processing; Statistics; Food; Food sources; Temperature requirements; Infection; Spores; Beans; Livestock; Bacillus stearothermophilus; Zea mays; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.anifeedsci.2005.12.011 ER - TY - JOUR T1 - Oligonucleotide-based Analysis of Differentially Expressed Genes in Hippocampus of Transgenic Mice Expressing NSE-controlled APPsw AN - 19821696; 7138225 AB - The complexity of Alzheimer's disease (AD) has made it difficult to examine its underlying mechanisms. A gene microarray offers a solution to the complexity through parallel analysis of most of the genes expressed in the hippocampal tissues from AD-transgenic and age-matched control littermates. This study examined the potential effect of APPsw over-expression on the modulation of genes for AD. To accomplish this, an oligonucleotide array was used with the large-scale screening of the hippocampus mRNA from 12-month-old APPsw-transgenic and control mice. There was a total of 116 differentially expressed genes, 59 up-regulated and 57 down-regulated, in the hippocampal region of the transgenic mice compared with the control mice. Initially, two of each of the down-regulated (Xlr3b and Mup3) and up-regulated genes (Serpina9 and Ccr6) were chosen for further investigation if the magnitude of change in these genes on the oligonucleotide array would correspond to those in the RT-PCR analysis from APPsw-transgenic mice. We also found that the changes in the differentially expressed genes are reliable. Thus, these genes might associate with AD neuropathology in neurodegenerative process of AD, although relevance of long lists altered genes should be evaluated in a future study. JF - Neurochemical Research AU - Jee, Seung W AU - Cho, Jung S AU - Kim, Chuel K AU - Hwang, Dae Y AU - Shim, Sun B AU - Lee, Su H AU - Sin, Ji S AU - Park, Jin H AU - Kim, Yang S AU - Choi, Soo Y AU - Kim, Yong K AD - National Institute of Toxicological Research, Korea FDA, Seoul, 122-704, Republic of Korea, kimyongkyu@hanmail.net Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1035 EP - 1044 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 31 IS - 8 SN - 0364-3190, 0364-3190 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Neuromodulation KW - Hippocampus KW - Overexpression KW - CCR6 protein KW - Alzheimer's disease KW - Polymerase chain reaction KW - Transgenic mice KW - DNA microarrays KW - Neuropathology KW - mRNA KW - W 30925:Genetic Engineering KW - N3 11008:Neurochemistry KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19821696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Oligonucleotide-based+Analysis+of+Differentially+Expressed+Genes+in+Hippocampus+of+Transgenic+Mice+Expressing+NSE-controlled+APPsw&rft.au=Jee%2C+Seung+W%3BCho%2C+Jung+S%3BKim%2C+Chuel+K%3BHwang%2C+Dae+Y%3BShim%2C+Sun+B%3BLee%2C+Su+H%3BSin%2C+Ji+S%3BPark%2C+Jin+H%3BKim%2C+Yang+S%3BChoi%2C+Soo+Y%3BKim%2C+Yong+K&rft.aulast=Jee&rft.aufirst=Seung&rft.date=2006-08-01&rft.volume=31&rft.issue=8&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-006-9117-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Neuromodulation; Hippocampus; CCR6 protein; Overexpression; Alzheimer's disease; Polymerase chain reaction; Transgenic mice; DNA microarrays; Neuropathology; mRNA DO - http://dx.doi.org/10.1007/s11064-006-9117-8 ER - TY - JOUR T1 - Subunit Recombinant Vaccine Protects against Monkeypox AN - 19773087; 7132018 AB - The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in combination with the equivalent recombinant proteins produced in Escherichia coli. Animals that received only DNA failed to produce high titer Abs, developed innumerable skin lesions after challenge, and died in a manner similar to placebo controls. By contrast, the animals vaccinated with proteins developed moderate to severe disease (20-155 skin lesions) but survived. Importantly, those immunized with DNA and boosted with proteins had mild disease with 15 or fewer lesions that resolved within days. DNA/protein immunization elicited Th responses and binding Ab titers to all four proteins that correlated negatively with the total lesion number. The sera of the immunized macaques recognized a limited number of linear B cell epitopes that are highly conserved among orthopoxviruses. Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox. JF - Journal of Immunology AU - Heraud, Jean-Michel AU - Edghill-Smith, Yvette AU - Ayala, Victor AU - Kalisz, Irene AU - Parrino, Janie AU - Kalyanaraman, Vaniambadi S AU - Manischewitz, Jody AU - King, Lisa R AU - Hryniewicz, Anna AU - Trindade, Christopher J AU - Hassett, Meredith AU - Tsai, Wen-Po AU - Venzon, David AU - Nalca, Aysegul AU - Vaccari, Monica AU - Silvera, Peter AU - Bray, Mike AU - Graham, Barney S AU - Golding, Hana AU - Hooper, Jay W AU - Franchini, Genoveffa AD - Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892. Southern Research Institute, Frederick, MD 21701. Advanced BioScience Laboratories, Kensington, MD 20895. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of General and Experimental Pathology, Medical University of Bialystok, Bialystok, Poland. Biostatistics and Data Management Section, National Cancer Institute, Bethesda, MD 20892. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702. Biodefense Clinical Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2552 EP - 2564 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 4 SN - 0022-1767, 0022-1767 KW - Rhesus macaque KW - Rhesus monkey KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Monkeypox KW - Lymphocytes B KW - Antibody response KW - Plasmids KW - Immunization KW - Smallpox KW - Antibodies KW - Vaccinia virus KW - Skin diseases KW - Escherichia coli KW - DNA KW - Macaca mulatta KW - Vaccines KW - Epitopes KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Subunit+Recombinant+Vaccine+Protects+against+Monkeypox&rft.au=Heraud%2C+Jean-Michel%3BEdghill-Smith%2C+Yvette%3BAyala%2C+Victor%3BKalisz%2C+Irene%3BParrino%2C+Janie%3BKalyanaraman%2C+Vaniambadi+S%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BHryniewicz%2C+Anna%3BTrindade%2C+Christopher+J%3BHassett%2C+Meredith%3BTsai%2C+Wen-Po%3BVenzon%2C+David%3BNalca%2C+Aysegul%3BVaccari%2C+Monica%3BSilvera%2C+Peter%3BBray%2C+Mike%3BGraham%2C+Barney+S%3BGolding%2C+Hana%3BHooper%2C+Jay+W%3BFranchini%2C+Genoveffa&rft.aulast=Heraud&rft.aufirst=Jean-Michel&rft.date=2006-08-01&rft.volume=177&rft.issue=4&rft.spage=2552&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smallpox; Antibodies; Monkeypox; Skin diseases; Lymphocytes B; DNA; Antibody response; Vaccines; Plasmids; Immunization; Epitopes; Vaccinia virus; Escherichia coli; Macaca mulatta ER - TY - JOUR T1 - Widening socioeconomic inequalities in US life expectancy, 1980-2000 AN - 19631550; 7361695 AB - Background This study examines changes in the extent of inequalities in life expectancy at birth and other ages in the United States between 1980 and 2000 by gender and socioeconomic deprivation levels. Methods A factor-based deprivation index consisting of 11 education, occupation, wealth, income distribution, unemployment, poverty, and housing quality indicators was used to define deprivation deciles, which were then linked to the US mortality data at the county-level. Life expectancy estimates were developed by age, gender, and deprivation levels for three 3 year time periods: 1980-82, 1989-91, and 1998-2000. Inequalities in life expectancy were measured by the absolute difference between the least-deprived group and each of the other deprivation deciles. Slope indices of inequality for each gender and time period were calculated by regressing life expectancy estimates on deprivation levels using weighted least squares models. Results Those in less-deprived groups experienced a longer life expectancy at each age than their counterparts in more-deprived groups. In 1980-82, the overall life expectancy at birth was 2.8 years longer for the least-deprived group than for the most-deprived group (75.8 vs 73.0 years). By 1998-2000, the absolute difference in life expectancy at birth had increased to 4.5 years (79.2 vs 74.7 years). The inequality indices also showed a substantial widening of the deprivation gradient in life expectancy during the study period for both males and females. Conclusions Between 1980 and 2000, those in higher socioeconomic groups experienced larger gains in life expectancy than those in more-deprived groups, contributing to the widening gap. JF - International Journal of Epidemiology AU - Singh, G K AU - Siahpush, M AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA, gsingh@hrsa.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 969 EP - 979 VL - 35 IS - 4 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - Mortality KW - USA KW - Education KW - unemployment KW - Housing KW - poverty KW - income KW - Gender KW - Socioeconomics KW - life span KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19631550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Widening+socioeconomic+inequalities+in+US+life+expectancy%2C+1980-2000&rft.au=Singh%2C+G+K%3BSiahpush%2C+M&rft.aulast=Singh&rft.aufirst=G&rft.date=2006-08-01&rft.volume=35&rft.issue=4&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdyl083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Education; unemployment; Housing; poverty; income; Gender; Socioeconomics; life span; USA DO - http://dx.doi.org/10.1093/ije/dyl083 ER - TY - JOUR T1 - Detection of Cashew Nut DNA in Spiked Baked Goods Using a Real-Time Polymerase Chain Reaction Method AN - 19500862; 7195763 AB - The detection of potentially allergenic foods, such as tree nuts, in food products is a major concern for the food processing industry. A real-time polymerase chain reaction (PCR) method was designed to determine the presence of cashew DNA in food products. The PCR amplifies a 67 bp fragment of the cashew 2S albumin gene, which is detected with a cashew-specific, dual-labeled TaqMan probe. This reaction will not amplify DNA derived from other tree nut species, such as almond, Brazil nut, hazelnut, and walnut, as well as 4 varieties of peanut. This assay was sensitive enough to detect 5 pg purified cashew DNA as well as cashew DNA in a spiked chocolate cookie sample containing 0.01% (100 mg/kg) cashew. JF - Journal of AOAC International AU - Brzezinski, J L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Dr, Cincinnati, OH 45237, USA, jennifer.brzezinski@fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1035 EP - 1038 VL - 89 IS - 4 SN - 1060-3271, 1060-3271 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Food processing KW - Arachis hypogaea KW - Prunus dulcis KW - Trees KW - Food KW - Probes KW - Nuts KW - Chocolate KW - Juglans KW - Anacardium KW - Prunus KW - Albumin KW - Polymerase chain reaction KW - Corylus KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+Cashew+Nut+DNA+in+Spiked+Baked+Goods+Using+a+Real-Time+Polymerase+Chain+Reaction+Method&rft.au=Brzezinski%2C+J+L&rft.aulast=Brzezinski&rft.aufirst=J&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Food processing; Trees; Food; Albumin; Probes; Chocolate; Nuts; Polymerase chain reaction; Arachis hypogaea; Prunus dulcis; Juglans; Anacardium; Corylus; Prunus ER - TY - JOUR T1 - Studies of the Effects of Neonatal Exposure to Genistein on the Developing Female Reproductive System AN - 19499246; 7195765 AB - Studies have shown that developmental exposure to genistein alters murine reproductive differentiation, resulting in abnormal ovarian development (multioocyte follicles) and uterine neoplasia later in life. Further, reproductive function was altered. Prolonged estrous cyclicity was observed following neonatal genistein treatment (0.5-50 mg/kg) on Days 1-5 with doseand age-related increase in severity. Fertility, determined at 2, 4, and 6 months, showed decreased numbers of genistein-treated females (0.5 or 5 mg/kg) delivering live pups and reduced numbers of pups. At 6 months, 60% of 0.5 mg/kg and 40% of 5 mg/kg groups delivered live pups compared to 100% of controls. At 2 months, half the mice treated with 25 mg/kg of genistein and none treated with 50 mg/kg delivered live pups, although half of the latter group showed signs of pregnancy with few small implantation sites. Ovarian function was disrupted in the low genistein-dosed mice with increased numbers of corpora lutea (CLs) compared to controls and increased ovulated oocytes following exogenous gonadotropins treatment. In contrast, mice treated with high genistein doses had decreased numbers of CLs; ovulation could be restored with exogenous gonadotropins. Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function. JF - Journal of AOAC International AU - Jefferson, W N AU - Padilla-Banks, E AU - Newbold, R R AD - National Institute of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA, jeffers1@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1189 EP - 1196 VL - 89 IS - 4 SN - 1060-3271, 1060-3271 KW - Toxicology Abstracts KW - Uterus KW - Fertility KW - Follicles KW - Gonadotropins KW - Reproductive system KW - Neoplasia KW - Pregnancy KW - Differentiation KW - Ovulation KW - Oocytes KW - Neonates KW - Estrus cycle KW - Genistein KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19499246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Studies+of+the+Effects+of+Neonatal+Exposure+to+Genistein+on+the+Developing+Female+Reproductive+System&rft.au=Jefferson%2C+W+N%3BPadilla-Banks%2C+E%3BNewbold%2C+R+R&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fertility; Uterus; Follicles; Gonadotropins; Neoplasia; Reproductive system; Pregnancy; Differentiation; Ovulation; Oocytes; Neonates; Genistein; Estrus cycle ER - TY - JOUR T1 - Methamphetamine Induces Autophagy and Apoptosis in a Mesencephalic Dopaminergic Neuronal Culture Model: Role of Cathepsin-D in Methamphetamine-Induced Apoptotic Cell Death AN - 19468642; 7165272 AB - Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-induced oxidative damage in dopaminergic neuronal systems remains unclear. The goals of the present article were twofold: (a) to develop an in vitro dopaminergic cell culture model to study cellular and molecular mechanisms underlying METH-ind-uced autophagy and apoptosis, and (b) to determine whether lysosomal protease cathepsin-D activation, resulting from the loss of lysosomal membrane integrity, contributes to METH-induced apoptosis. To accomplish these goals, we characterized morphological and biochemical changes in an immortalized mesencephalic dopaminergic neuronal cell line (N27 cells) following treatment with METH. Exposure of METH (2 mM) to N27 cells resulted in the appearance of cytoplasmic vacuolar structures reminiscent of autophagic vacuoles within 3 h. In order to ascertain the identity of the vacuolar structures that are formed following METH exposure, immunohistochemical staining for markers of autophagy were performed. LAMP 2, a classical marker of autophagolysosomes, revealed an extensive punctuate pattern of distribution on the vacuolar membrane surface, with exclusive localization in the cytoplasm. Additionally, using DNA fragmentation analysis we showed a dose-dependent increase in fragmented DNA in METH treated N27 cells. Since METH-induced autophagy preceded DNA fragmentation, we tested whether dysfunction of the autophagolysosomal system contributes to nuclear damage. Immunofluorescence studies with cathepsin-D demonstrated a granular pattern of staining in untreated cells, whereas an increased cathepsin- D immunoreactivity with a globular pattern of staining was observed in METH-treated cells. Nevertheless, blockade of cathepsin-D activation by pepstatin-A, cathepsin-D inhibitor, failed to alter METH-induced DNA fragmentation. Collectively, these results demonstrate that N27 dopaminergic neuronal cell model may serve as an excellent in vitro model to study the mechanisms of METH-induced autophagy and apoptosis. Furthermore, it is less likely that cathepsin-D may serve as a trigger for the induction of apoptosis subsequent to exposure of N27 dopaminergic neuronal cells to METH. JF - Annals of the New York Academy of Sciences AU - Kanthasamy, Arthi AU - Anantharam, V AU - Ali, Syed F AU - Kanthasamy, A G AD - Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011-1250, USA Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, Arkansas 72079, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 234 EP - 244 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1074 SN - 0077-8923, 0077-8923 KW - Sustainability Science Abstracts; CSA Neurosciences Abstracts KW - Phylogeny KW - Mortality KW - Molecular modelling KW - Membranes KW - Apoptosis KW - Biochemistry KW - Stress KW - Cell culture KW - Immunofluorescence KW - DNA fragmentation KW - Methamphetamine KW - Dopamine KW - Oxidative stress KW - Cytoplasm KW - Neurotoxicity KW - Immunoreactivity KW - Vacuoles KW - DNA KW - Proteins KW - Proteinase KW - Organelles KW - M3 1010:Issues in Sustainable Development KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Methamphetamine+Induces+Autophagy+and+Apoptosis+in+a+Mesencephalic+Dopaminergic+Neuronal+Culture+Model%3A+Role+of+Cathepsin-D+in+Methamphetamine-Induced+Apoptotic+Cell+Death&rft.au=Kanthasamy%2C+Arthi%3BAnantharam%2C+V%3BAli%2C+Syed+F%3BKanthasamy%2C+A+G&rft.aulast=Kanthasamy&rft.aufirst=Arthi&rft.date=2006-08-01&rft.volume=1074&rft.issue=&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Molecular modelling; Apoptosis; Cell culture; Immunofluorescence; DNA fragmentation; Methamphetamine; Dopamine; Oxidative stress; Cytoplasm; Vacuoles; Immunoreactivity; Neurotoxicity; Proteinase; Organelles; Mortality; Membranes; Biochemistry; DNA; Proteins; Stress ER - TY - JOUR T1 - Current and future issues in the manufacturing and development of monoclonal antibodies AN - 19454168; 7040814 AB - Despite a slow beginning, monoclonal antibodies have had many successes over the past decade. It is important that these successes continue, bringing more products for more indications to market. Although manufacturing is not the most common cause of product failure, product quality issues can delay antibody development. Manufacturing has depended on the triad of process validation, process control and product testing. Applying product knowledge proactively to manufacturing (quality by design) may allow greater flexibility and maintain or improve product quality. An integrated approach to biological characterization is an important aspect of product knowledge. Greater product knowledge also facilitates development in other disciplines. Independent of manufacturing strategy, there are a number of regulatory hurdles in initial and ongoing antibody development. These are described to help prevent unnecessary delays. JF - Advanced Drug Delivery Reviews AU - Kozlowski, Steven AU - Swann, Patrick AD - Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, steven.kozlowski@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 707 EP - 722 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 58 IS - 5-6 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Monoclonal antibodies KW - Reviews KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Current+and+future+issues+in+the+manufacturing+and+development+of+monoclonal+antibodies&rft.au=Kozlowski%2C+Steven%3BSwann%2C+Patrick&rft.aulast=Kozlowski&rft.aufirst=Steven&rft.date=2006-08-01&rft.volume=58&rft.issue=5-6&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2006.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Reviews; Drug delivery DO - http://dx.doi.org/10.1016/j.addr.2006.05.002 ER - TY - JOUR T1 - A Nationwide Population-Based Study Identifying Health Disparities Between American Indians/Alaska Natives and the General Populations Living in Select Urban Counties AN - 19367981; 7127222 AB - OBJECTIVES: Despite their increasing numbers, little is known about the health of American Indians/Alaska Natives living in urban areas. We examined the health status of American Indian/Alaska Native populations served by 34 federally funded urban Indian health organizations. METHODS: We analyzed US census data and vital statistics data for the period 1990 to 2000. RESULTS: Disparities were revealed in socioeconomic, maternal and child health, and mortality indicators between American Indians/Alaska Natives and the general populations in urban Indian health organization service areas and nationwide. American Indians/Alaska Natives were approximately twice as likely as these general populations to be poor, to be unemployed, and to not have a college degree. Similar differences were observed in births among mothers who received late or no prenatal care or consumed alcohol and in mortality attributed to sudden infant death syndrome, chronic liver disease, and alcohol consumption. CONCLUSIONS: We found health disparities between American Indians/Alaska Natives and the general populations living in selected urban areas and nationwide. Such disparities can be addressed through improvements in health care access, high-quality data collection, and policy initiatives designed to provide sufficient resources and a more unified vision of the health of urban American Indians/Alaska Natives. JF - American Journal of Public Health AU - Castor, Mei L AU - Smyser, Michael S AU - Taualii, Maile M AU - Park, Alice N AU - Lawson, Shelley A AU - Forquera, Ralph A AD - Mei L. Castor, Maile M. Taualii, Alice N. Park, and Ralph A. Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, Wash. Mei L. Castor is also with the Indian Health Service, Albuquerque, NM. Michael S. Smyser and Shelly A. Lawson are with Public Health-Seattle and King County, Seattle Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1478 EP - 1484 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 8 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - Alcohol KW - Mortality KW - Data collection KW - Health care KW - Liver KW - Socioeconomics KW - INE, USA, Alaska KW - vital statistics KW - Urban areas KW - Public health KW - sudden infant death syndrome KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=A+Nationwide+Population-Based+Study+Identifying+Health+Disparities+Between+American+Indians%2FAlaska+Natives+and+the+General+Populations+Living+in+Select+Urban+Counties&rft.au=Castor%2C+Mei+L%3BSmyser%2C+Michael+S%3BTaualii%2C+Maile+M%3BPark%2C+Alice+N%3BLawson%2C+Shelley+A%3BForquera%2C+Ralph+A&rft.aulast=Castor&rft.aufirst=Mei&rft.date=2006-08-01&rft.volume=96&rft.issue=8&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Alcohol; Data collection; Health care; Liver; Socioeconomics; vital statistics; sudden infant death syndrome; Public health; Urban areas; INE, USA, Alaska ER - TY - JOUR T1 - CXCL16 Influences the Nature and Specificity of CpG-Induced Immune Activation AN - 19367723; 7129082 AB - Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. This work establishes that CXCL16, a membrane-bound scavenger receptor, influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. This is the first example of a surface receptor modifying the cellular specificity and nature of the immune response mediated by an intracellular TLR. JF - Journal of Immunology AU - Gursel, Mayda AU - Gursel, Ihsan AU - Mostowski, Howard S AU - Klinman, Dennis M AD - Section of Retroviral Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1575 EP - 1580 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 3 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chemokines KW - Lymphocytes B KW - Helper cells KW - Immune system KW - CpG islands KW - Oligonucleotides KW - Inflammation KW - Dendritic cells KW - Lymphocytes T KW - Cytokines KW - Immune response KW - CXCL16 protein KW - scavenger receptors KW - F 06960:Molecular Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CXCL16+Influences+the+Nature+and+Specificity+of+CpG-Induced+Immune+Activation&rft.au=Gursel%2C+Mayda%3BGursel%2C+Ihsan%3BMostowski%2C+Howard+S%3BKlinman%2C+Dennis+M&rft.aulast=Gursel&rft.aufirst=Mayda&rft.date=2006-08-01&rft.volume=177&rft.issue=3&rft.spage=1575&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemokines; Lymphocytes B; Immune system; Helper cells; CpG islands; Oligonucleotides; Inflammation; Dendritic cells; Lymphocytes T; Cytokines; CXCL16 protein; Immune response; scavenger receptors ER - TY - JOUR T1 - A novel ceftazidime-hydrolysing extended-spectrum {szligbeta}-lactamase, CTX-M-54, with a single amino acid substitution at position 167 in the omega loop AN - 19366310; 7128463 AB - OBJECTIVES: To characterize a novel ceftazidime-hydrolysing CTX-M mutant, designated CTX-M-54, produced by Klebsiella pneumoniae clinical isolate BDK0419 and to investigate its genetic environment. METHODS: Antimicrobial susceptibilities were determined by disc diffusion and agar dilution methods, and the double-disc synergy test was carried out. Detection of genes encoding class A {szligbeta}-lactamases was performed by PCR amplification, and the genetic organization of the bla sub(CTX-M-54) gene was investigated by PCR and sequencing of the regions surrounding this gene. Kinetic parameters were determined from purified CTX-M-54. RESULTS: The strain BDK0419 contained a transferable plasmid with a molecular size of similar to 21 kbp that carries both bla sub(SHV-2a) and bla sub(CTX-M-54) {szligbeta}-lactamase genes, along with two other plasmids. The bla sub(CTX-M-54) gene was flanked upstream by an ISEcp1 insertion sequence and downstream by an IS903-like element. CTX-M-54 had a P167Q substitution within the omega loop region of class A {szligbeta}-lactamases compared with the sequence of CTX-M-3. The MIC of ceftazidime for K. pneumoniae BDK0419 was 16-fold higher than that of cefotaxime; however, the kinetic parameter of CTX-M-54 against ceftazidime revealed a low catalytic efficiency. CONCLUSIONS: This work shows once again that novel CTX-M enzymes with an expanded activity towards ceftazidime through a single amino acid substitution can be identified from clinical isolates. Thus, detection of CTX-M enzymes can no longer be based solely on the resistance phenotypes of clinical isolates towards ceftazidime and cefotaxime. JF - Journal of Antimicrobial Chemotherapy AU - Bae, Il Kwon AU - Lee, Byung Ho AU - Hwang, Hyun Yong AU - Jeong, Seok Hoon AU - Hong, Seong Geun AU - Chang, Chulhun L AU - Kwak, Hyo-Sun AU - Kim, Hyoung Jin AU - Youn, Hasik AD - Department of Laboratory Medicine, Kosin University College of Medicine 602-030, 34 Amnam-Dong, Suh-Gu, Busan, Korea. Department of Laboratory Medicine, Pochon CHA University College of Medicine 463-712, 351 Yatap-Dong, Bundang-Gu, Sungnam, Korea. Department of Laboratory Medicine, Pusan National University School of Medicine 602-739, Suh-Gu, Ami-Dong 1-10, Busan, Korea. Center for Food Safety Evaluation, Korea Food and Drug Administration 122-704, 231 Jinheung-Ro, Eunpyung-Gu, Seoul, Korea. R&D Park, LG Life Sciences Ltd 305-380, 104-1 Moonji-Dong, Yuseong-Gu, Daejeon, Korea Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 315 EP - 319 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 2 SN - 0305-7453, 0305-7453 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Agar KW - Cefotaxime KW - Amino acid substitution KW - Enzymes KW - Plasmids KW - Insertion sequences KW - Minimum inhibitory concentration KW - Ceftazidime KW - Kinetics KW - Polymerase chain reaction KW - Diffusion KW - Klebsiella pneumoniae KW - W 30915:Pharmaceuticals & Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=A+novel+ceftazidime-hydrolysing+extended-spectrum+%7Bszligbeta%7D-lactamase%2C+CTX-M-54%2C+with+a+single+amino+acid+substitution+at+position+167+in+the+omega+loop&rft.au=Bae%2C+Il+Kwon%3BLee%2C+Byung+Ho%3BHwang%2C+Hyun+Yong%3BJeong%2C+Seok+Hoon%3BHong%2C+Seong+Geun%3BChang%2C+Chulhun+L%3BKwak%2C+Hyo-Sun%3BKim%2C+Hyoung+Jin%3BYoun%2C+Hasik&rft.aulast=Bae&rft.aufirst=Il&rft.date=2006-08-01&rft.volume=58&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Ceftazidime; Agar; Amino acid substitution; Cefotaxime; Kinetics; Polymerase chain reaction; Enzymes; Diffusion; Insertion sequences; Plasmids; Minimum inhibitory concentration; Klebsiella pneumoniae ER - TY - JOUR T1 - Hemoglobin adducts in workers exposed to benzidine and azo dyes AN - 19364928; 7131032 AB - Benzidine (Bz) is a known human carcinogen. Several azo dyes have been synthesized with Bz. Bz can be metabolically released from azo dyes. In a group of Indian workers producing Bz and azo dyes the presence of hemoglobin (Hb) adducts was investigated. The following Hb adducts were identified and quantified by GC-MS: Bz, N-acetylbenzidine (AcBz), 4-aminobiphenyl (4ABP), aniline. 4ABP and aniline were quantitatively the major adducts. In the exposed workers (n = 33) all correlations between 4ABP, Bz and AcBz were r = 0.89 (P < 0.01) or greater. The group of workers exposed to Bz (Bz workers, n = 15) had 10-17-fold higher adduct levels than the workers exposed to dyes (dye workers, n = 18). 4ABP can be metabolically released from Bz and azo dyes. Aniline can be metabolically released from azo dyes. Therefore, the presence of 4ABP and aniline as Hb adducts is a consequence of exposure to the parent compounds or to the exposure of Bz and azo dyes and a consequent metabolical release of the arylamine moiety. The mean adduct ratios of 4ABP/(AcBz + Bz) varied up to 4-fold across all seven factories. Therefore, it is possible that 4ABP may have derived from general contamination in the work environment or endogenous metabolism, or a combination of the two. Since 4ABP is also a known human carcinogen, tumors observed in workers exposed to Bz or Bz dyes might be caused by both compounds. Further, these results suggest that understanding the role that genetic variants in NAT1 and NAT2 play in modifying the impact of Bz on bladder cancer risk may be complicated, as N-acetylation detoxifies 4ABP and activates Bz. JF - Carcinogenesis AU - Beyerbach, Armin AU - Rothman, Nathaniel AU - Bhatnagar, Vijai K AU - Kashyap, Rekha AU - Sabbioni, Gabriele AD - Institute of Environmental and Occupational Toxicology Casella Postale 108, CH-6780 Airolo, Switzerland. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, 20892, USA. National Institute of Occupational Health Ahmedabad, India. Walther-Straub-Institut fuer Pharmakologie und Toxikologie, Ludwig-Maximilians-Universitaet Muenchen Nussbaumstrasse 26, 80336 Muenchen, Germany Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1600 EP - 1606 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - N-Acetylbenzidine KW - Contamination KW - Azo dyes KW - Urinary bladder KW - Adducts KW - Tumors KW - Carcinogens KW - Cancer KW - Hemoglobin KW - Dyes KW - Carcinogenesis KW - Metabolism KW - Occupational exposure KW - Aniline KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19364928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hemoglobin+adducts+in+workers+exposed+to+benzidine+and+azo+dyes&rft.au=Beyerbach%2C+Armin%3BRothman%2C+Nathaniel%3BBhatnagar%2C+Vijai+K%3BKashyap%2C+Rekha%3BSabbioni%2C+Gabriele&rft.aulast=Beyerbach&rft.aufirst=Armin&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - N-Acetylbenzidine; Contamination; Urinary bladder; Azo dyes; Adducts; Carcinogens; Tumors; Cancer; Hemoglobin; Dyes; Carcinogenesis; Occupational exposure; Metabolism; Aniline ER - TY - JOUR T1 - Analysis of secA1 Gene Sequences for Identification of Nocardia Species AN - 19362620; 7131836 AB - Molecular methodologies, especially 16S rRNA gene sequence analysis, have allowed the recognition of many new species of Nocardia and to date have been the most precise methods for identifying isolates reliably to the species level. We describe here a novel method for identifying Nocardia isolates by using sequence analysis of a portion of the secA1 gene. A region of the secA1 gene of 30 type or reference strains of Nocardia species was amplified using secA1-specific primers. Sequence analysis of 468 bp allowed clear differentiation of all species, with a range of interspecies similarity of 85.0% to 98.7%. Corresponding 16S rRNA gene sequences of a 1,285-bp region for the same isolates showed a range of interspecies similarity of 94.4 to 99.8%. In addition to the type and reference strains, a 468-bp fragment of the secA1 gene was sequenced from 40 clinical isolates of 12 Nocardia species previously identified by 16S rRNA gene sequence analysis. The secA1 gene sequences of most isolates showed >99.0% similarity to the secA1 sequences of the type or reference strain to which their identification corresponded, with a range of 95.3 to 100%. Comparison of the deduced 156 amino acid sequences of the SecA1 proteins of the clinical isolates showed between zero and two amino acid residue differences compared to that of the corresponding type or reference strain. Sequencing of the secA1 gene, and using deduced amino acid sequences of the SecA1 protein, may provide a more discriminative and precise method for the identification of Nocardia isolates than 16S rRNA gene sequencing. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Zelazny, Adrian M AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2760 EP - 2766 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 8 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Differentiation KW - Primers KW - Nocardia KW - rRNA 16S KW - New species KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19362620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Analysis+of+secA1+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BZelazny%2C+Adrian+M%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2006-08-01&rft.volume=44&rft.issue=8&rft.spage=2760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Differentiation; Primers; rRNA 16S; New species; Nocardia ER - TY - JOUR T1 - Arsenic Induces NAD(P)H-quinone Oxidoreductase I by Disrupting the Nrf2.Keap1.Cul3 Complex and Recruiting Nrf2.Maf to the Antioxidant Response Element Enhancer AN - 19328853; 7061610 AB - The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adaptive responses in mammalian species. The biological targets of arsenic are largely unknown at present. We analyzed the signaling pathway for induction of detoxification gene NAD(P)H-quinone oxidoreductase (Nqo1) by arsenic. Genetic and biochemical evidence revealed that induction required cap `n' collar basic leucine zipper transcription factor Nrf2 and the antioxidant response element (ARE) of Nqo1. Arsenic stabilized Nrf2 protein, extending the t one half of Nrf2 from 21 to 200 min by inhibiting the Keap1.Cul3-dependent ubiquitination and proteasomal turnover of Nrf2. Arsenic markedly inhibited the ubiquitination of Nrf2 but did not disrupt the Nrf2.Keap1.Cul3 association in the cytoplasm. In the nucleus, arsenic, but not phenolic antioxidant tert-butylhydroquinone, dissociated Nrf2 from Keap1 and Cul3 followed by dimerization of Nrf2 with a Maf protein (Maf G/Maf K). Chromatin immunoprecipitation demonstrated that Nrf2 and Maf associated with the endogenous Nqo1 ARE enhancer constitutively. Arsenic substantially increased the ARE occupancy by Nrf2 and Maf. In addition, Keap1 was shown to be ubiquitinated in the cytoplasm and deubiquitinated in the nucleus in the presence of arsenic without changing the protein level, implicating nuclear-cytoplasmic recycling of Keap1. Our data reveal that arsenic activates the Nrf2/Keap1 signaling pathway through a distinct mechanism from that by antioxidants and suggest an "on-switch" model of Nqo1 transcription in which the binding of Nrf2.Maf to ARE controls both the basal and inducible expression of Nqo1. JF - Journal of Biological Chemistry AU - He, Xiaoqing AU - Chen, Michael G AU - Lin, Gary X AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 23620 EP - 23631 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 33 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts KW - Detoxification KW - Arsenic KW - Antioxidants KW - Chromatin KW - Regulatory sequences KW - Immunoprecipitation KW - NRF2 protein KW - Recycling KW - Maf protein KW - Models KW - Enhancers KW - ubiquitination KW - Transcription factors KW - Cytoplasm KW - oxidoreductase KW - phenolic compounds KW - NAD(P)H dehydrogenase (quinone) KW - Leucine zipper proteins KW - Nuclei KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19328853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Arsenic+Induces+NAD%28P%29H-quinone+Oxidoreductase+I+by+Disrupting+the+Nrf2.Keap1.Cul3+Complex+and+Recruiting+Nrf2.Maf+to+the+Antioxidant+Response+Element+Enhancer&rft.au=He%2C+Xiaoqing%3BChen%2C+Michael+G%3BLin%2C+Gary+X%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2006-08-01&rft.volume=281&rft.issue=33&rft.spage=23620&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Detoxification; Arsenic; Antioxidants; Chromatin; Regulatory sequences; Immunoprecipitation; NRF2 protein; Maf protein; Recycling; Models; ubiquitination; Enhancers; Cytoplasm; Transcription factors; phenolic compounds; oxidoreductase; NAD(P)H dehydrogenase (quinone); Leucine zipper proteins; Nuclei; Signal transduction ER - TY - JOUR T1 - Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles AN - 19327415; 7070914 AB - Diesel exhaust particles (DEPs) have been shown to activate oxidant generation by alveolar macrophages (AMs), alter xenobiotic metabolic pathways, and modify the balance of pro-antiinflammatory cytokines. In this study we investigated the role of nitric oxide (NO) in DEP-mediated and DEP organic extract (DEPE)-mediated inflammatory responses and evaluated the interaction of inducible NO synthase (iNOS) and cytochrome P450 1A1 (CYP1A1). Male Sprague-Dawley rats were intratracheally (IT) instilled with saline, DEPs (35 mg/kg), or DEPEs (equivalent to 35 mg DEP/kg), with or without further treatment with an iNOS inhibitor, aminoguanidine (AG; 100 mg/kg), by intraperitoneal injection 30 min before and 3, 6, and 9 hr after IT exposure. At 1 day postexposure, both DEPs and DEPEs induced iNOS expression and NO production by AMs. AG significantly lowered DEP- and DEPE-induced iNOS activity but not the protein level while attenuating DEPE- but not DEP-mediated pulmonary inflammation, airway damage, and oxidant generation by AMs. DEP or DEPE exposure resulted in elevated secretion of both interleukin (IL)-12 and IL-10 by AMs. AG significantly reduced DEP- and DEPE-activated AMs in IL-12 production. In comparison, AG inhibited IL-10 production by DEPE-exposed AMs but markedly increased its production by DEP-exposed AMs, suggesting that NO differentially regulates the pro- and antiinflammatory cytokine balance in the lung. Both DEPs and DEPEs induced CYP1A1 expression. AG strongly inhibited CYP1A1 activity and lung S9 activity-dependent 2-aminoanthracene mutagenicity. These studies show that NO plays a major role in DEPE-induced lung inflammation and CYP-dependent mutagen activation but a lesser role in particulate-induced inflammatory damage. JF - Environmental Health Perspectives AU - Zhao, Hongwen AU - Barger, M W AU - Ma, JKH AU - Castranova, V AU - Ma, JYC AD - Pathology and Physiology Research Branch, HELD, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA, jym1@cdc.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1253 EP - 1258 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Macrophages KW - Mutagens KW - Cooperation KW - Environmental health KW - Particulates KW - Xenobiotics KW - Interleukin 10 KW - Rats KW - Interleukin 12 KW - Metabolic pathways KW - Cytokines KW - Exhaust emissions KW - Respiratory tract KW - Mutagenicity KW - 2-Aminoanthracene KW - Exhausts KW - Inflammation KW - Nitric-oxide synthase KW - Cytochrome KW - Lung KW - Proteins KW - Diesel KW - Nitric oxide KW - Cytochrome P450 KW - Oxidants KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19327415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cooperation+of+the+Inducible+Nitric+Oxide+Synthase+and+Cytochrome+P450+1A1+in+Mediating+Lung+Inflammation+and+Mutagenicity+Induced+by+Diesel+Exhaust+Particles&rft.au=Zhao%2C+Hongwen%3BBarger%2C+M+W%3BMa%2C+JKH%3BCastranova%2C+V%3BMa%2C+JYC&rft.aulast=Zhao&rft.aufirst=Hongwen&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Mutagens; Mutagenicity; Cooperation; Xenobiotics; 2-Aminoanthracene; Interleukin 10; Inflammation; Exhausts; Nitric-oxide synthase; Interleukin 12; Lung; Metabolic pathways; Cytokines; Nitric oxide; Diesel; Cytochrome P450; Oxidants; Respiratory tract; Rats; Cytochrome; Proteins; Environmental health; Particulates; Exhaust emissions DO - http://dx.doi.org/10.1289/ehp.9063 ER - TY - JOUR T1 - Hierarchical models for probabilistic dose-response assessment AN - 19297085; 7042919 AB - Probabilistic risk assessment is gaining acceptance as the most appropriate way to characterize and communicate uncertainties in estimates of human health risk and/or reference levels of exposure such as benchmark doses. Although probabilistic techniques are well established in the exposure-assessment component of the National Research Council's risk-assessment paradigm, they are less well developed in the dose-response-assessment component. This paper proposes the use of hierarchical statistical models as tools for implementing probabilistic dose-response assessments, in that such models provide a natural connection between the pharmacokinetic (PK) and pharmacodynamic (PD) components of dose-response models. The results show that incorporating internal dose information into dose-response assessments via the coupling of PK and PD models in a hierarchical structure can reduce the uncertainty in the dose-response assessment of risk. However, information on the mean of the internal dose distribution is sufficient; having information on the variance of internal dose does not affect the uncertainty in the resulting estimates of excess risks or benchmark doses. In addition, the complexity of a PK model of internal dose does not affect how the variability in risk is measured via the ultimate endpoint. JF - Regulatory Toxicology and Pharmacology AU - Kodell, R L AU - Chen, J J AU - Delongchamp, R R AU - Young, J F AD - National Center for Toxicological Research, 3900 NCTR Road, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, rkodell@nctr.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 265 EP - 272 PB - Elsevier Inc. VL - 45 IS - 3 SN - 0273-2300, 0273-2300 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Risk assessment KW - Mathematical models KW - Dose-response effects KW - Statistical analysis KW - Pharmacokinetics KW - Pharmacodynamics KW - H 14000:Toxicology KW - R2 23060:Medical and environmental health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19297085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Hierarchical+models+for+probabilistic+dose-response+assessment&rft.au=Kodell%2C+R+L%3BChen%2C+J+J%3BDelongchamp%2C+R+R%3BYoung%2C+J+F&rft.aulast=Kodell&rft.aufirst=R&rft.date=2006-08-01&rft.volume=45&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2006.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mathematical models; Statistical analysis; Pharmacodynamics; Pharmacokinetics; Dose-response effects DO - http://dx.doi.org/10.1016/j.yrtph.2006.05.002 ER - TY - JOUR T1 - Exposure to school children as a risk factor in a community outbreak of hepatitis A in young adults: a case control study AN - 19284284; 7026779 AB - To investigate risk factors during a community outbreak of hepatitis A we carried out a case- control study of 35 cases and 49 matched controls using an interviewer-administered questionnaire on clinical history, travel, household details including domestic toilet facilities, infectious contacts, and food history. Of 99 cases notified in the city during the outbreak year, 50 (51%) were young adults age 15-34 years. Hepatitis A infection was independently associated with household contact with a case (P=0.0005), and sharing a household with children in primary school (OR 3.4, 95% CI 1.2-9.5, P=0.008) with risk increasing with number of primary-school pupils in the household (X super(2) for linear trend 6.47, P=0.01). We concluded that in a population with a low prevalence of hepatitis A, adults who live in the same household as primary-school-age children are at increased risk of acquiring the infection during community outbreaks. JF - Epidemiology and Infection AU - Roberts, R J AU - Palmer AD - National Public Health Service, Preswylfa, Mold, Flintshire, UK, richard.roberts@nphs.wales.nhs.uk Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 803 EP - 807 PB - Cambridge University Press, UK, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 134 IS - 4 SN - 0950-2688, 0950-2688 KW - Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - Travel KW - Historical account KW - Inventories KW - Toilets KW - Food KW - Hepatitis A virus KW - outbreaks KW - Children KW - Infection KW - hepatitis A KW - infectious diseases KW - Schools KW - Risk factors KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Exposure+to+school+children+as+a+risk+factor+in+a+community+outbreak+of+hepatitis+A+in+young+adults%3A+a+case+control+study&rft.au=Roberts%2C+R+J%3BPalmer&rft.aulast=Roberts&rft.aufirst=R&rft.date=2006-08-01&rft.volume=134&rft.issue=4&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268805005625 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Travel; Risk assessment; Inventories; Toilets; Food; Risk factors; Infection; Children; Historical account; infectious diseases; Schools; outbreaks; hepatitis A; Hepatitis A virus DO - http://dx.doi.org/10.1017/S0950268805005625 ER - TY - JOUR T1 - Determining the microbiological criteria for lot rejection from the performance objective or food safety objective AN - 17271463; 6989901 AB - The Microbiological Criteria (MC) is a set of parameters used to determine whether a specific lot of food is acceptable or not. These parameters are the microbial test protocol and its sensitivity, the confidence level that an unacceptable lot will be detected, the number of samples to be taken and the number of positive samples that are allowed before rejecting the lot. Determining the microbiological criteria begins with knowledge of the distribution of contamination from samples within a lot, particularly within a lot that is just at the unacceptable level of the microbial hazard. The just unacceptable lot can be defined by the Food Safety Objective (FSO) or Performance Objectives (PO), the small fraction of samples that can exceed these values and the standard deviation of the samples from the lot. With this information, a microbial test protocol is chosen to have a sensitivity level that would detect between approximately 15% and 45% of the samples. A confidence level for the MC and the number of positive samples that would be acceptable (c value which is usually zero) are also chosen. With this information the number of samples (n) required can be calculated. A critical factor in setting the microbiological criteria is the sensitivity of the microbiological test (m value). The sample size (weight) and sampling procedure can affect the standard deviation of the samples, particularly foods with non-homogeneous distribution and low numbers of microorganisms. Sampling, sample preparation and analytical procedures that reduce the variation between the samples will affect the choice of m value and maximum lot mean that meets the MC. JF - International Journal of Food Microbiology AU - Whiting, R C AU - Rainosek, A AU - Buchanan, R L AU - Miliotis, M AU - LaBarre, D AU - Long, W AU - Ruple, A AU - Schaub, S AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA, richard.whiting@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 263 EP - 267 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 110 IS - 3 SN - 0168-1605, 0168-1605 KW - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Risk analysis KW - Risk assessment KW - Attribute testing KW - Standard deviation KW - Microorganisms KW - Standards KW - Microbial contamination KW - Sampling KW - Food contamination KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17271463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Determining+the+microbiological+criteria+for+lot+rejection+from+the+performance+objective+or+food+safety+objective&rft.au=Whiting%2C+R+C%3BRainosek%2C+A%3BBuchanan%2C+R+L%3BMiliotis%2C+M%3BLaBarre%2C+D%3BLong%2C+W%3BRuple%2C+A%3BSchaub%2C+S&rft.aulast=Whiting&rft.aufirst=R&rft.date=2006-08-01&rft.volume=110&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2006.04.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Standard deviation; Microorganisms; Sampling; Food contamination; Standards; Microbial contamination DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2006.04.038 ER - TY - JOUR T1 - Increased susceptibility of the lungs of hyperthyroid rats to oxidant injury: Specificity of effects AN - 17256118; 6989387 AB - Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. This observation raised the possibility that pulmonary damage from other oxidant substances might be greater in a hyperthyroid state. To address this hypothesis, pulmonary responses to crystalline silica, a particulate with oxidant properties, were evaluated in normal or hyperthyroid adult male rats. To induce a hyperthyroid condition, time-release pellets containing thyroxine were implanted subcutaneously; control rats received placebo pellets. After 7 days, the animals were exposed to saline or silica (0.1 mg/100 g BW or 1.0 mg/100 g BW) by intratracheal instillation. Following silica treatment, there was a dose-related increase in bronchoalveolar lavage (BAL) albumin levels and neutrophil numbers. However, the effects of silica were similar in both normal and hyperthyroid rats. These findings were confirmed and contrasted with those regarding ozone (1 ppm, 4 h inhalation) in a subsequent experiment. The results indicated that, although exposure to either ozone or silica resulted in increases in BAL albumin levels and neutrophil numbers, only responses to ozone were enhanced in hyperthyroid rats. These findings suggest that specificity exists in regards to the modulation of oxidant-induced lung damage and inflammation by thyroid hormones. JF - Toxicology AU - Huffman, L J AU - Beighley, C M AU - Frazer, D G AU - McKinney, W G AU - Porter, D W AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S 2015, 1095 Willowdale Road, Morgantown, WV 26505, United States, DPorter@cdc.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 119 EP - 127 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 225 IS - 2-3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Silica KW - Ozone KW - Thyroid hormone KW - Rat KW - Inhalation KW - Injuries KW - Leukocytes (neutrophilic) KW - Toxicity KW - Alveoli KW - Inflammation KW - Thyroid hormones KW - Bronchus KW - Lung KW - Albumin KW - Thyroxine KW - Trachea KW - Oxidants KW - Hyperthyroidism KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17256118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Increased+susceptibility+of+the+lungs+of+hyperthyroid+rats+to+oxidant+injury%3A+Specificity+of+effects&rft.au=Huffman%2C+L+J%3BBeighley%2C+C+M%3BFrazer%2C+D+G%3BMcKinney%2C+W+G%3BPorter%2C+D+W&rft.aulast=Huffman&rft.aufirst=L&rft.date=2006-08-01&rft.volume=225&rft.issue=2-3&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2006.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Injuries; Leukocytes (neutrophilic); Toxicity; Alveoli; Inflammation; Thyroid hormones; Silica; Bronchus; Lung; Albumin; Thyroxine; Trachea; Hyperthyroidism; Oxidants; Ozone DO - http://dx.doi.org/10.1016/j.tox.2006.05.008 ER - TY - JOUR T1 - Understanding recombinant expression of membrane proteins AN - 17044927; 7003405 AB - Over the past 15 years, numerous reports have been published on the recombinant expression of integral membrane proteins. Some proteins accumulate in the membrane to high levels, whereas other often closely related proteins are barely detected. Understanding the underlying reasons for this variation has proven difficult. Recent studies in this area have provided new insight into the response of host cells to membrane protein expression and into the mechanism of membrane insertion. The successful overproduction of some membrane proteins was shown to be linked to the avoidance of stress responses in the host cell. Furthermore, the cell response to membrane protein production has been quantified and several genes that are either upregulated or downregulated when yields of a membrane-inserted protein are poor were identified. Progress has also been made in understanding how the translocon, which is the site of protein translocation and membrane insertion, decides whether a protein segment is integrated into the membrane or not. Building upon such experiments will lead to targeted approaches for recombinant membrane protein expression. JF - Current Opinion in Biotechnology AU - Grisshammer, Reinhard AD - super(a)Laboratory of Molecular Biology of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA, rkgriss@helix.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 337 EP - 340 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Protein transport KW - Protein biosynthesis KW - Reviews KW - Stress KW - Membrane proteins KW - W3 33340:Other proteins, peptides, amino acids KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17044927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Understanding+recombinant+expression+of+membrane+proteins&rft.au=Grisshammer%2C+Reinhard&rft.aulast=Grisshammer&rft.aufirst=Reinhard&rft.date=2006-08-01&rft.volume=17&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Protein biosynthesis; Reviews; Stress; Membrane proteins DO - http://dx.doi.org/10.1016/j.copbio.2006.06.001 ER - TY - CPAPER T1 - Bioinformatics, the Multiple-Biomarker Classifier Problem, Complexity, and Uncertainty T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40216709; 4342198 JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Wagner, R F Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=Bioinformatics%2C+the+Multiple-Biomarker+Classifier+Problem%2C+Complexity%2C+and+Uncertainty&rft.au=Wagner%2C+R+F&rft.aulast=Wagner&rft.aufirst=R&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - In situ structure characterization of airborne carbon nanofibres by a tandem mobility-mass analysis. AN - 733576648; 19661613 AB - Carbon nanofibres aerosolized by the agitation of as-produced commercial powder have been characterized in situ by using the differential mobility analyser-aerosol particle mass analyser (DMA-APM) method to determine their structural properties such as the effective density and fractal dimension for toxicology study. The effective density of the aerosolized carbon nanofibres decreased from 1.2 to 0.4 g cm(-3) as the mobility diameters increased from 100 to 700 nm, indicating that the carbon nanofibres had open structures with an overall void that increased with increasing diameter, due to increased agglomeration of the nanofibres. This was confirmed by transmission electron microscopy (TEM) observation, showing that 100 nm mobility diameter nanofibres were predominantly single fibres, while doubly or triply attached fibres were seen at mobility diameters of 200 and 400 nm. Effective densities calculated using Cox's theory were in reasonable agreement with experimental values. The mass fractal dimension of the carbon nanofibres was found to be 2.38 over the size range measured and higher than that of single-walled carbon nanotubes (SWCNTs), suggesting that the carbon nanofibres have more compact structure than SWCNTs. JF - Nanotechnology AU - Ku, Bon Ki AU - Emery, Mark S AU - Maynard, Andrew D AU - Stolzenburg, Mark R AU - McMurry, Peter H AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA. Y1 - 2006/07/28/ PY - 2006 DA - 2006 Jul 28 SP - 3613 EP - 3621 VL - 17 IS - 14 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733576648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotechnology&rft.atitle=In+situ+structure+characterization+of+airborne+carbon+nanofibres+by+a+tandem+mobility-mass+analysis.&rft.au=Ku%2C+Bon+Ki%3BEmery%2C+Mark+S%3BMaynard%2C+Andrew+D%3BStolzenburg%2C+Mark+R%3BMcMurry%2C+Peter+H&rft.aulast=Ku&rft.aufirst=Bon&rft.date=2006-07-28&rft.volume=17&rft.issue=14&rft.spage=3613&rft.isbn=&rft.btitle=&rft.title=Nanotechnology&rft.issn=1361-6528&rft_id=info:doi/10.1088%2F0957-4484%2F17%2F14%2F042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1088/0957-4484/17/14/042 ER - TY - JOUR T1 - Development of multiclass methods for drug residues in eggs: hydrophilic solid-phase extraction cleanup and liquid chromatography/tandem mass spectrometry analysis of tetracycline, fluoroquinolone, sulfonamide, and beta-lactam residues. AN - 68647499; 16848505 AB - A method was developed for detection of a variety of polar drug residues in eggs via liquid chromatography/tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). A total of twenty-nine target analytes from four drug classes-sulfonamides, tetracyclines, fluoroquinolones, and beta-lactams-were extracted from eggs using a hydrophilic-lipophilic balance polymer solid-phase extraction (SPE) cartridge. The extraction technique was developed for use at a target concentration of 100 ng/mL (ppb), and it was applied to eggs containing incurred residues from dosed laying hens. The ESI source was tuned using a single, generic set of tuning parameters, and analytes were separated with a phenyl-bonded silica cartridge column using an LC gradient. In a related study, residues of beta-lactam drugs were not found by LC/MS/MS in eggs from hens dosed orally with beta-lactam drugs. LC/MS/MS performance was evaluated on two generations of ion trap mass spectrometers, and key operational parameters were identified for each instrument. The ion trap acquisition methods could be set up for screening (a single product ion) or confirmation (multiple product ions). The lower limit of detection for screening purposes was 10-50 ppb (sulfonamides), 10-20 ppb (fluoroquinolones), and 10-50 ppb (tetracyclines), depending on the drug, instrument, and acquisition method. Development of this method demonstrates the feasibility of generic SPE, LC, and MS conditions for multiclass LC/MS residue screening. JF - Journal of agricultural and food chemistry AU - Heller, David N AU - Nochetto, Cristina B AU - Rummel, Nathan G AU - Thomas, Michael H AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA. david.heller@fda.hhs.gov Y1 - 2006/07/26/ PY - 2006 DA - 2006 Jul 26 SP - 5267 EP - 5278 VL - 54 IS - 15 SN - 0021-8561, 0021-8561 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Sulfonamides KW - Tetracyclines KW - beta-Lactams KW - Index Medicus KW - Fluoroquinolones -- analysis KW - Sulfonamides -- analysis KW - Animals KW - Chickens KW - Tetracyclines -- analysis KW - beta-Lactams -- analysis KW - Female KW - Spectrometry, Mass, Electrospray Ionization KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Eggs -- analysis KW - Anti-Bacterial Agents -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68647499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Development+of+multiclass+methods+for+drug+residues+in+eggs%3A+hydrophilic+solid-phase+extraction+cleanup+and+liquid+chromatography%2Ftandem+mass+spectrometry+analysis+of+tetracycline%2C+fluoroquinolone%2C+sulfonamide%2C+and+beta-lactam+residues.&rft.au=Heller%2C+David+N%3BNochetto%2C+Cristina+B%3BRummel%2C+Nathan+G%3BThomas%2C+Michael+H&rft.aulast=Heller&rft.aufirst=David&rft.date=2006-07-26&rft.volume=54&rft.issue=15&rft.spage=5267&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-29 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study. AN - 68572237; 16730138 AB - Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis. The first 18 patients received 1 g of intrarectal amifostine suspension placed 30-45 min before each radiation treatment. The following 12 patients received 2 g of amifostine. Total dose prescribed ranged from 66 to 76 Gy. All patients were treated with three-dimensional conformal radiation therapy. The suspension remained intrarectal during treatment and was expelled after treatment. For gastrointestinal symptoms, during treatment and follow-up, all patients had a Radiation Therapy Oncology Group (RTOG) grade recorded. Median follow-up was 18 months (range, 6-24 months). With 2 g vs. 1 g amifostine, there was a nearly significant decrease in RTOG Grade 2 acute rectal toxicity. Seven weeks after the start of radiation therapy, the incidence of Grade 2 toxicity was 33% in the 1-g group (6/18) compared with 0% (0/12) in the 2-g group (p=0.06). No Grade 3 toxicity or greater occurred in this study. This trial suggests greater rectal radioprotection from acute effects with 2 g vs. 1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis. JF - International journal of radiation oncology, biology, physics AU - Singh, Anurag K AU - Ménard, Cynthia AU - Guion, Peter AU - Simone, Nicole L AU - Smith, Sharon AU - Crouse, Nancy Sears AU - Godette, Denise J AU - Cooley-Zgela, Theresa AU - Sciuto, Linda C AU - Coleman, Jonathan AU - Pinto, Peter AU - Albert, Paul S AU - Camphausen, Kevin AU - Coleman, C Norman AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 1008 EP - 1013 VL - 65 IS - 4 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Radiotherapy, Conformal KW - Humans KW - Aged KW - Pilot Projects KW - Administration, Rectal KW - Statistics, Nonparametric KW - Male KW - Radiation-Protective Agents -- administration & dosage KW - Radiation Injuries -- prevention & control KW - Rectum -- radiation effects KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Proctitis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+suspension+may+protect+against+acute+proctitis+during+radiation+therapy+for+prostate+cancer%3A+a+pilot+study.&rft.au=Singh%2C+Anurag+K%3BM%C3%A9nard%2C+Cynthia%3BGuion%2C+Peter%3BSimone%2C+Nicole+L%3BSmith%2C+Sharon%3BCrouse%2C+Nancy+Sears%3BGodette%2C+Denise+J%3BCooley-Zgela%2C+Theresa%3BSciuto%2C+Linda+C%3BColeman%2C+Jonathan%3BPinto%2C+Peter%3BAlbert%2C+Paul+S%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-07-15&rft.volume=65&rft.issue=4&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Mutations of the Flavivirus Conserved 3_Squote_Sl in the West Nile Genome Result in Attenuation of Neurovirulence T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40218922; 4339243 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Yu, Li AU - Putnak, Robert AU - Pletnev, Alexander AU - Markoff, Lewis Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Mutation KW - Genomes KW - Neurovirulence KW - Flavivirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40218922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Mutations+of+the+Flavivirus+Conserved+3_Squote_Sl+in+the+West+Nile+Genome+Result+in+Attenuation+of+Neurovirulence&rft.au=Yu%2C+Li%3BPutnak%2C+Robert%3BPletnev%2C+Alexander%3BMarkoff%2C+Lewis&rft.aulast=Yu&rft.aufirst=Li&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Characterization of the Role of F and HN Surface Proteins in Neurovirulence of Mumps Virus Strains Urabe AM9 and 88-1961 using Reverse Genetics Technology T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40218621; 4339398 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Sauder, Christian AU - Vandenburgh, Kari AU - Zhang, Cheryl AU - Duprex, Paul AU - Carbone, Kathryn AU - Rubin, Steven Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Genetics KW - Mumps KW - Neurovirulence KW - Strains KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40218621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=In+Vivo+Characterization+of+the+Role+of+F+and+HN+Surface+Proteins+in+Neurovirulence+of+Mumps+Virus+Strains+Urabe+AM9+and+88-1961+using+Reverse+Genetics+Technology&rft.au=Sauder%2C+Christian%3BVandenburgh%2C+Kari%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Influenza Virus Gene Sequence Associated with Variability in Neurotoxicity T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40212932; 4339268 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Qi, Li AU - Carbone, Kathryn AU - Ye, Zhiping AU - Rubin, Steven Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Neurotoxicity KW - Influenza KW - Influenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40212932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Changes+in+Influenza+Virus+Gene+Sequence+Associated+with+Variability+in+Neurotoxicity&rft.au=Qi%2C+Li%3BCarbone%2C+Kathryn%3BYe%2C+Zhiping%3BRubin%2C+Steven&rft.aulast=Qi&rft.aufirst=Li&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repair of 3_Squote_-End Deletions in Dengue 2 Virus T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40206840; 4339559 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Teramoto, Tadahisa AU - Mattoo, Pravina AU - Kohno, Yukari AU - Padmanabhan, R AU - Markoff, Lewis AU - Falgout, Barry Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Deletion KW - Dengue virus type 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40206840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Inhibition+of+mammalian+target+of+rapamycin+modulates+expression+of+adhesion+molecules+in+endothelial+cells&rft.au=Wood%2C+Steven+C%3BBushar%2C+Grace%3BTesfamariam%2C+Belay&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.009 L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis and the Role of dsRNA Activated Mechanisms in HAV 18F Infected Frhk4 Cells T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40205280; 4339910 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Kulka, M AU - Goswami, B AU - Ayodeji, M AU - Ngo, D AU - Cebula, T Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Double-stranded RNA KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40205280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Apoptosis+and+the+Role+of+dsRNA+Activated+Mechanisms+in+HAV+18F+Infected+Frhk4+Cells&rft.au=Kulka%2C+M%3BGoswami%2C+B%3BAyodeji%2C+M%3BNgo%2C+D%3BCebula%2C+T&rft.aulast=Kulka&rft.aufirst=M&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Evaluation of Genetic Stability of New Live WNV Vaccine Candidate by Hybridization with Microarrays of Overlapping Oligonucleotides T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40204993; 4339475 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Laassri, Majid AU - Alexander, Pletnev AU - Chumakov, Konstantin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Vaccines KW - Oligonucleotides KW - Hybridization KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40204993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Mutations+induced+by+carcinogenic+doses+of+aristolochic+acid+in+kidney+of+Big+Blue+transgenic+rats&rft.au=Chen%2C+Ling%3BMei%2C+Nan%3BYao%2C+Lei%3BChen%2C+Tao&rft.aulast=Chen&rft.aufirst=Ling&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.008 L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Partition Coefficients for Toxic Agents in Multiple Phase Foods: Separation of Raw Whole Milk T2 - 2006 Joint Annual Meeting of the American Dairy Science Association and American Society of Animal Science AN - 40136656; 4300621 JF - 2006 Joint Annual Meeting of the American Dairy Science Association and American Society of Animal Science AU - Schlesser, J E AU - Jablonski, J E AU - Mariappagoudar, P Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Milk KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40136656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+American+Society+of+Animal+Science&rft.atitle=Partition+Coefficients+for+Toxic+Agents+in+Multiple+Phase+Foods%3A+Separation+of+Raw+Whole+Milk&rft.au=Schlesser%2C+J+E%3BJablonski%2C+J+E%3BMariappagoudar%2C+P&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2006/Scientific_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacology and Toxicology of Peroxisome Proliferator Activated Receptor Agonists: Differential Apoptosis of Troglitazone and Rosiglitazone T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40250957; 4364587 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Rhee, Herman M Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Pharmacology KW - Apoptosis KW - Peroxisome proliferator-activated receptors KW - Rosiglitazone KW - Troglitazone KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40250957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Pharmacology+and+Toxicology+of+Peroxisome+Proliferator+Activated+Receptor+Agonists%3A+Differential+Apoptosis+of+Troglitazone+and+Rosiglitazone&rft.au=Rhee%2C+Herman+M&rft.aulast=Rhee&rft.aufirst=Kumar&rft.date=2006-09-01&rft.volume=46&rft.issue=9&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2006.00936.x L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Fluoroquinolones on the Cardiovascular System in Telemetered Conscious Dogs T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40249400; 4364644 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Hee, Lee Yun AU - Hwan, Choi Ki AU - Suk, Yun Jae AU - Deahyun, Cho AU - Joo-Il, Kim Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Cardiovascular system KW - Fluoroquinolones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40249400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Effects+of+Fluoroquinolones+on+the+Cardiovascular+System+in+Telemetered+Conscious+Dogs&rft.au=Hee%2C+Lee+Yun%3BHwan%2C+Choi+Ki%3BSuk%2C+Yun+Jae%3BDeahyun%2C+Cho%3BJoo-Il%2C+Kim&rft.aulast=Hee&rft.aufirst=Lee&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tracheal Epithelial Cell Shrinkage Induced by Hyperosmolar Solution T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40247974; 4366497 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Fedan, J S AU - Jing, Y AU - Dowdy, J A AU - Ismailoglu, U B Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Osmotic pressure KW - Epithelial cells KW - Atrophy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Tracheal+Epithelial+Cell+Shrinkage+Induced+by+Hyperosmolar+Solution&rft.au=Fedan%2C+J+S%3BJing%2C+Y%3BDowdy%2C+J+A%3BIsmailoglu%2C+U+B&rft.aulast=Darensburg&rft.aufirst=Tahera&rft.date=2006-09-01&rft.volume=12&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765606296271 L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Agencies Role in Educational Program Related to Drug Development and Regulatory Science T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40247541; 4364487 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Lesko, Lawrence J Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Drug development KW - Education KW - Governments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Regulatory+Agencies+Role+in+Educational+Program+Related+to+Drug+Development+and+Regulatory+Science&rft.au=Lesko%2C+Lawrence+J&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discussion on the Chinese, American and European Guidelines for the Medicines in the Treatment of Hypertension T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40243606; 4365090 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Lin, Yan AU - Zhen-gang, Wang Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Hypertension UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40243606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Discussion+on+the+Chinese%2C+American+and+European+Guidelines+for+the+Medicines+in+the+Treatment+of+Hypertension&rft.au=Lin%2C+Yan%3BZhen-gang%2C+Wang&rft.aulast=Lin&rft.aufirst=Yan&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Emerging issues in occupational safety and health. AN - 68855925; 16967836 AB - In developed countries, changes in the nature of work and the workforce may necessitate recalibrating the vision of occupational safety and health (OSH) researchers, practitioners, and policymakers to increase the focus on the most important issues. New methods of organizing the workplace, extensive labor contracting, expansion of service and knowledge sectors, increase in small business, aging and immigrant workers, and the continued existence of traditional hazards in high-risk sectors such as construction, mining, agriculture, health care, and transportation support the need to address: 1) broader consideration of the role and impact of work, 2) relationship between work and psychological dysfunction, 3) increased surveillance basis for research and intervention, 4) overcoming barriers to the conduct and use of epidemiologic research, 5) information and knowledge transfer and application, 6) economic issues in prevention, and 7) the global interconnectedness of OSH. These issues are offered to spur thinking as new national research agendas for OSH are considered for developed countries. JF - International journal of occupational and environmental health AU - Schulte, Paul A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226-1922, USA. PY - 2006 SP - 273 EP - 277 VL - 12 IS - 3 SN - 1077-3525, 1077-3525 KW - Index Medicus KW - Information Dissemination -- methods KW - International Cooperation KW - Humans KW - Occupational Diseases -- prevention & control KW - Employment -- trends KW - Employment -- economics KW - Occupational Diseases -- psychology KW - Occupational Health KW - Workplace -- standards KW - Workplace -- organization & administration KW - Public Policy KW - Workplace -- economics KW - Developed Countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68855925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Mycobacterium+tuberculosis+Delta+RD1+Delta+panCD%3A+A+safe+and+limited+replicating+mutant+strain+that+protects+immunocompetent+and+immunocompromised+mice+against+experimental+tuberculosis&rft.au=Sambandamurthy%2C+Vasan+K%3BDerrick%2C+Steven+C%3BHsu%2C+Tsungda%3BChen%2C+Bing%3BLarsen%2C+Michelle+H%3BJalapathy%2C+Kripa+V%3BChen%2C+Mei%3BKim%2C+John%3BPorcelli%2C+Steven+A%3BChan%2C+John%3BMorris%2C+Sheldon+L%3BJacobs%2C+William+R&rft.aulast=Sambandamurthy&rft.aufirst=Vasan&rft.date=2006-09-01&rft.volume=24&rft.issue=37-39&rft.spage=6309&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: Results of the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68714974; 16889449 AB - To present national data on the prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders for sedatives, tranquilizers, opioids, and amphetamines. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a face-to-face nationally representative survey of 43,093 adults conducted during 2001 and 2002. Lifetime prevalences of nonmedical use of sedatives, tranquilizers, opioids, and amphetamines were 4.1%, 3.4%, 4.7%, and 4.7%, respectively. Corresponding rates of abuse and/or dependence on these substances were 1.1%, 1.0%, 1.4%, and 2.0%. The odds of nonmedical prescription drug use and drug use disorders were generally greater among men, Native Americans, young and middle-aged, those who were widowed/ separated/divorced or never married, and those residing in the West. Abuse/dependence liability was greatest for amphetamines, and nonmedical prescription drug use disorders were highly comorbid with other Axis I and II disorders. The majority of individuals with non-medical prescription drug use disorders never received treatment. Nonmedical prescription drug use and disorders are pervasive in the U.S. population and highly comorbid with other psychiatric disorders. Native Americans had significantly greater rates of nonmedical prescription drug use and drug use disorders, highlighting the need for culturally-sensitive prevention and intervention programs. Unprecedented comorbidity between nonmedical prescription drug use disorders and between nonmedical prescription drug use disorders and illicit drug use disorders suggests that the typical individual abusing or dependent on these drugs obtained them illegally, rather than through a physician. Amphetamines had the greatest abuse/dependence liability, and recent increases in the potency of illegally manufactured amphetamines may portend an epidemic in the youngest NESARC cohort. JF - The Journal of clinical psychiatry AU - Huang, Boji AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Hasin, Deborah S AU - Ruan, W June AU - Saha, Tulshi D AU - Smith, Sharon M AU - Goldstein, Risë B AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1062 EP - 1073 VL - 67 IS - 7 SN - 0160-6689, 0160-6689 KW - Hypnotics and Sedatives KW - 0 KW - Psychotropic Drugs KW - Street Drugs KW - Tranquilizing Agents KW - Index Medicus KW - Amphetamine-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Humans KW - Street Drugs -- adverse effects KW - Health Surveys KW - Adult KW - Psychotropic Drugs -- adverse effects KW - Hypnotics and Sedatives -- adverse effects KW - Tranquilizing Agents -- adverse effects KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Drug Prescriptions -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68714974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+and+comorbidity+of+nonmedical+prescription+drug+use+and+drug+use+disorders+in+the+United+States%3A+Results+of+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Huang%2C+Boji%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BHasin%2C+Deborah+S%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BSmith%2C+Sharon+M%3BGoldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=67&rft.issue=7&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The indirect detection of bleach (sodium hypochlorite) in beverages as evidence of product tampering. AN - 68700509; 16882227 AB - Bleach (sodium hypochlorite) has been identified as the adulterant in a relatively large number of product tamperings that have been investigated by the Forensic Chemistry Center (FCC) of the U.S. Food and Drug Administration. In this work, household bleach was added to 23 different beverages at each of three levels. The impact of sodium hypochlorite on these beverages over a 13-day study period was evaluated using the following techniques: diphenylamine spot test for oxidizing agents, potassium iodide-starch test paper for oxidizing agents, pH, iodometric titration for quantitating hypochlorite, ion chromatography for chloride and chlorate quantitation, automated headspace sampling with gas chromatography-flame ionization detection (GC-FID) for determination of chloroform, and visual and organoleptic observations. This study has shown that hypochlorite is fragile when added to most common beverages and typically breaks down either partially or completely over time. In cases where a beverage is suspected of being adulterated with bleach but tests for hypochlorite are negative, it is still possible to characterize the product to demonstrate that the results are consistent with the addition of bleach. An adulterated product will give a positive test for oxidizing agents using the diphenylamine spot test. It is likely that the pH of the adulterated product will be higher than a control of that product. Ion chromatographic analysis shows elevated chloride and chlorate as compared with a control. And, chloroform may also be detected by GC-FID especially if the beverage that was adulterated contains citric acid. JF - Journal of forensic sciences AU - Jackson, David S AU - Crockett, David F AU - Wolnik, Karen A AD - Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, OH 45237, USA. david.jackson@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 827 EP - 831 VL - 51 IS - 4 SN - 0022-1198, 0022-1198 KW - Disinfectants KW - 0 KW - Sodium Hypochlorite KW - DY38VHM5OD KW - Index Medicus KW - Flame Ionization KW - Hydrogen-Ion Concentration KW - Chromatography, Ion Exchange KW - Disinfectants -- poisoning KW - Sodium Hypochlorite -- poisoning KW - Beverages -- analysis KW - Forensic Medicine -- methods KW - Sodium Hypochlorite -- chemistry KW - Disinfectants -- chemistry KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68700509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+forensic+sciences&rft.atitle=The+indirect+detection+of+bleach+%28sodium+hypochlorite%29+in+beverages+as+evidence+of+product+tampering.&rft.au=Jackson%2C+David+S%3BCrockett%2C+David+F%3BWolnik%2C+Karen+A&rft.aulast=Jackson&rft.aufirst=David&rft.date=2006-07-01&rft.volume=51&rft.issue=4&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Journal+of+forensic+sciences&rft.issn=00221198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMAM methods update: a laboratory response to concerns about technologically outdated and problematic methods. AN - 68640878; 16835165 AB - The National Institute for Occupational Safety Health (NIOSH) publishes the NIOSH Manual of Analytical Methods (NMAM). The NMAM, although subject to various revisions and the incorporation of supplemental editions over the years, still contains many methods that are technologically outdated or problematic, as identified in a recent survey of the various users of the NMAM. Whereas the survey identified a number of problematic methods based on various chromatographic techniques, those selected for inclusion in this project employed analysis by gas chromatography (GC). The GC methods selected for evaluation were categorized as Phases 1, 2, 3, and 4 based on necessity as determined by the results of the client survey or internal assessment. The Phase 1 methods included: NMAM 1606 (Acetonitrile), NMAM 2005 (Nitroaromatic Compounds), and NMAM 1453 (Vinyl Acetate); the Phase 2 methods: NMAM 1003 (Halogenated Hydrocarbons), NMAM 1501 (Aromatic Hydrocarbons), NMAM 2555 (Ketones I), and NMAM 1403 (Alcohols IV); the Phase 3 methods: NMAM 2552 (Methyl Acrylate), NMAM 2537 (Methyl and Ethyl Methacrylate), and NMAM 2553 (Ketones II), and the Phase 4 methods: NMAM 2556 (Isophorone), NMAM 1460 (Isopropyl Acetate), and NMAM 1618 (Isopropyl Ether). All methods previously specifying packed column chromatography have been evaluated using the appropriate fused silica capillary column. Improvements in individual analyte desorption efficiencies were achieved at concentrations substantially lower than those used in the previous methods. Most analytes evaluated had their respective limit of detection lowered by a factor of ten-to twentyfold. Thirty-day storage stability studies, previously lacking in a number of methods or for new analytes, were successfully completed to meet current method development criteria. Additional benefits resulting from this effort included the incorporation of single analyte methods into chemically related multianalyte methods and the evaluation of certain isomers, such as the methylstyrenes and xylenes, which previously could not be separated. JF - Journal of occupational and environmental hygiene AU - Pendergrass, Stephanie M AU - Ernst, Jennifer L AU - Dollberg, Donald D AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. smp5@cdc.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 390 EP - 396 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Air Pollution, Indoor -- analysis KW - Environmental Monitoring -- methods KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68640878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=NMAM+methods+update%3A+a+laboratory+response+to+concerns+about+technologically+outdated+and+problematic+methods.&rft.au=Pendergrass%2C+Stephanie+M%3BErnst%2C+Jennifer+L%3BDollberg%2C+Donald+D&rft.aulast=Pendergrass&rft.aufirst=Stephanie&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of laboratory simulated road paving-like asphalt by high-performance liquid chromatography and gas chromatography-mass spectrometry. AN - 68634783; 16835160 AB - Prolonged, extensive exposure to asphalt fume has been associated with several adverse health effects. Inhaled polycyclic aromatic hydrocarbons (PAHs) from asphalt fume exposure are of concern. The objective of this study was to characterize both qualitative and quantitative differences between fumes generated at 150 degrees C and 180 degrees C using a well-controlled laboratory road paving fume generation system. Fumes were characterized by total volatile and particulate concentration, simulated boiling point profile, and specific PAH content. The mean concentrations of the volatile fractions generated at 180 degrees C and 150 degrees C were 23.3 mg/m3 and 11.2 mg/m3, respectively, demonstrating a statistically significant shift in concentration. The mean concentrations of the particulate fractions generated at 180 degrees C and 150 degrees C were 42.4 mg/m3 and 28.0 mg/m3, respectively. The simulated boiling point profile did not show a significant qualitative difference between the fumes generated at the two temperatures. Naphthalene, acenaphthene, fluorene, phenanthrene, fluoranthene, pyrene, and chrysene were identified and quantified from the fumes. JF - Journal of occupational and environmental hygiene AU - Law, Brandon F AU - Stone, Samuel AU - Frazer, David AU - Siegel, Paul D AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. bhl7@cdc.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 343 EP - 350 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Hydrocarbons KW - Polycyclic Compounds KW - asphalt KW - 8052-42-4 KW - Index Medicus KW - Transition Temperature KW - Air Pollutants, Occupational -- isolation & purification KW - Gas Chromatography-Mass Spectrometry KW - Volatilization KW - Occupational Exposure -- analysis KW - Chromatography, High Pressure Liquid KW - Polycyclic Compounds -- chemistry KW - Hydrocarbons -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68634783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Characterization+of+laboratory+simulated+road+paving-like+asphalt+by+high-performance+liquid+chromatography+and+gas+chromatography-mass+spectrometry.&rft.au=Law%2C+Brandon+F%3BStone%2C+Samuel%3BFrazer%2C+David%3BSiegel%2C+Paul+D&rft.aulast=Law&rft.aufirst=Brandon&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of multilocus sequence typing, pulsed-field gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates. AN - 68617516; 16825363 AB - In the United States, multidrug-resistant phenotypes of Salmonella enterica serotype Newport (commonly referred to as MDR-AmpC) have emerged in animals and humans and have become a major public health problem. Although pulsed-field gel electrophoresis (PFGE) is the current "gold standard" typing method for Salmonella, multilocus sequence typing (MLST) may be more relevant to investigations exploring evolutionary and population biology relationships. In this study, 81 Salmonella enterica serotype Newport isolates from humans, food animals, and retail foods were examined for antimicrobial susceptibility and characterized using PFGE and MLST of seven genes, aroC, dnaN, hemD, hisD, purE, sucA, and thrA. Forty-nine percent of the isolates were resistant to nine or more of the tested antimicrobials. Salmonella isolates displayed resistance most often to sulfamethoxazole (57%), streptomycin (56%), tetracycline (56%), ampicillin (52%), and ceftiofur (49%) and, to a lesser extent, to kanamycin (19%), trimethoprim-sulfamethoxazole (17%), and gentamicin (11%). A total of 43 PFGE patterns were generated using XbaI, indicating a genetically diverse population. The largest PFGE cluster contained isolates from clinically ill swine, cattle, and humans. MLST resulted in 12 sequence types (STs), with one type encompassing 62% of the strains. Ten new sequence types and one novel allele type were identified. Furthermore, MLST typing showed that strains closely related by PFGE clustered in major STs, whereas more distantly related strains were separated into two clusters by PFGE. The results of this study demonstrated that the MLST scheme employed here clustered S. enterica serovar Newport isolates in distinct molecular populations, and strain discrimination was enhanced by combining PFGE, antimicrobial susceptibility, and MLST results. JF - Journal of clinical microbiology AU - Harbottle, H AU - White, D G AU - McDermott, P F AU - Walker, R D AU - Zhao, S AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Rd., Laurel, MD 20708, USA. heather.harbottle@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 2449 EP - 2457 VL - 44 IS - 7 SN - 0095-1137, 0095-1137 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - endodeoxyribonuclease XBAI KW - EC 3.1.21.- KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - Index Medicus KW - Salmonella Infections, Animal -- microbiology KW - Animals KW - Genes, Bacterial KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Chickens -- microbiology KW - Serotyping KW - DNA Fingerprinting KW - Salmonella Infections -- microbiology KW - Drug Resistance, Multiple, Bacterial KW - Swine -- microbiology KW - Cattle KW - Turkeys -- microbiology KW - Food Microbiology KW - Polymorphism, Restriction Fragment Length KW - Meat Products -- microbiology KW - DNA, Bacterial -- chemistry KW - DNA, Bacterial -- genetics KW - Salmonella enterica -- isolation & purification KW - Salmonella enterica -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Sequence Analysis, DNA KW - Salmonella enterica -- classification KW - Bacterial Typing Techniques KW - Salmonella enterica -- drug effects KW - Microbial Sensitivity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68617516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+multilocus+sequence+typing%2C+pulsed-field+gel+electrophoresis%2C+and+antimicrobial+susceptibility+typing+for+characterization+of+Salmonella+enterica+serotype+Newport+isolates.&rft.au=Harbottle%2C+H%3BWhite%2C+D+G%3BMcDermott%2C+P+F%3BWalker%2C+R+D%3BZhao%2C+S&rft.aulast=Harbottle&rft.aufirst=H&rft.date=2006-07-01&rft.volume=44&rft.issue=7&rft.spage=2449&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Microbiol. 2003 Oct;11(10):479-87 [14557031] J Microbiol Methods. 2005 Nov;63(2):173-84 [16226640] J Clin Microbiol. 2003 Dec;41(12):5366-71 [14662912] Clin Infect Dis. 2003 Dec 15;37(12):1585-90 [14689335] Appl Environ Microbiol. 2004 Jan;70(1):318-23 [14711658] Int J Food Microbiol. 2004 Feb 15;91(1):51-62 [14967560] J Bacteriol. 2004 Mar;186(5):1518-30 [14973027] J Food Prot. 2004 Apr;67(4):651-7 [15083714] J Clin Microbiol. 2000 Mar;38(3):1008-15 [10698988] Appl Environ Microbiol. 2000 Dec;66(12):5273-81 [11097902] J Clin Microbiol. 2000 Dec;38(12):4492-8 [11101585] Emerg Infect Dis. 2001 May-Jun;7(3):382-9 [11384513] Avian Dis. 2001 Oct-Dec;45(4):875-86 [11785892] J Clin Microbiol. 2002 May;40(5):1626-35 [11980932] J Clin Microbiol. 2002 Jun;40(6):1963-71 [12037049] J Clin Microbiol. 2002 Dec;40(12):4544-6 [12454149] J Clin Microbiol. 2002 Dec;40(12):4679-84 [12454172] J Appl Microbiol. 2003;94(1):65-72 [12492925] J Clin Microbiol. 2003 Feb;41(2):675-9 [12574266] Emerg Infect Dis. 2003 Apr;9(4):496-9 [12702235] J Clin Microbiol. 2003 Sep;41(9):4270-8 [12958256] J Clin Microbiol. 2003 Sep;41(9):4279-84 [12958257] J Clin Microbiol. 2003 Oct;41(10):4578-82 [14532185] J Clin Microbiol. 2003 Oct;41(10):4833-5 [14532235] Clin Infect Dis. 2004 Apr 15;38 Suppl 3:S127-34 [15095181] MMWR Morb Mortal Wkly Rep. 2004 Apr 30;53(16):338-43 [15123986] J Clin Microbiol. 2004 May;42(5):2314-6 [15131222] Appl Environ Microbiol. 2004 Jul;70(7):4030-4 [15240279] Trends Microbiol. 2004 Aug;12(8):373-7 [15276613] Epidemiol Infect. 2004 Aug;132(4):571-7 [15310157] Appl Environ Microbiol. 2004 Sep;70(9):5305-14 [15345414] J Clin Microbiol. 2004 Sep;42(9):4275-83 [15365023] J Infect. 2004 Nov;49(4):291-6 [15474626] N Engl J Med. 1987 Mar 5;316(10):565-70 [3807951] J Clin Microbiol. 1988 Nov;26(11):2465-6 [3069867] J Med Microbiol. 1994 Jan;40(1):15-22 [7904649] Microbiol Immunol. 1995;39(9):673-6 [8577280] Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9869-74 [9275218] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3140-5 [9501229] Vet Microbiol. 1998 Mar 31;61(3):215-27 [9631533] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] J Clin Microbiol. 2004 Dec;42(12):5681-8 [15583299] J Clin Microbiol. 2004 Dec;42(12):5722-30 [15583305] J Clin Microbiol. 2005 Jan;43(1):340-7 [15634992] J Clin Microbiol. 2005 Mar;43(3):1205-9 [15750084] Ugeskr Laeger. 2005 Feb 14;167(7):764-6 [15779263] J Clin Microbiol. 2005 Apr;43(4):1604-11 [15814973] J Clin Microbiol. 2005 Apr;43(4):1776-81 [15814998] J Clin Microbiol. 2005 May;43(5):2215-9 [15872244] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W728-33 [15980573] J Clin Microbiol. 2005 Jul;43(7):3519-21 [16000495] J Clin Microbiol. 2005 Aug;43(8):3688-98 [16081897] Antimicrob Agents Chemother. 2005 Oct;49(10):4061-7 [16189081] J Infect Dis. 2003 Dec 1;188(11):1707-16 [14639542] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlates of public health workforce acceptance of smallpox immunization in Virginia. AN - 68602294; 16817805 AB - By October 24, 2003, 38,577 of 500,000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Cross-sectional survey, conducted in May 2004. We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Among nonvaccinees (n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees (n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6-85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1-22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6-81.1). Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed. JF - Public health nursing (Boston, Mass.) AU - Bryant-Genevier, Marthe AU - Sommer, Sandra AU - McMahon, Ann AU - Ball, Robert AU - Braun, M Miles AD - CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland 20852-1448, USA. marthe.bryant-genevier@fda.hhs.gov PY - 2006 SP - 339 EP - 346 VL - 23 IS - 4 SN - 0737-1209, 0737-1209 KW - Index Medicus KW - Nursing KW - Cross-Sectional Studies KW - Virginia KW - Humans KW - Adult KW - Disaster Planning KW - Aged KW - Middle Aged KW - Bioterrorism KW - Male KW - Female KW - Attitude of Health Personnel KW - Occupational Diseases -- prevention & control KW - Immunization Programs KW - Health Knowledge, Attitudes, Practice KW - Smallpox -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68602294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+nursing+%28Boston%2C+Mass.%29&rft.atitle=Correlates+of+public+health+workforce+acceptance+of+smallpox+immunization+in+Virginia.&rft.au=Bryant-Genevier%2C+Marthe%3BSommer%2C+Sandra%3BMcMahon%2C+Ann%3BBall%2C+Robert%3BBraun%2C+M+Miles&rft.aulast=Bryant-Genevier&rft.aufirst=Marthe&rft.date=2006-07-01&rft.volume=23&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Public+health+nursing+%28Boston%2C+Mass.%29&rft.issn=07371209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. AN - 68598132; 16815813 AB - The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins, which transport a variety of compounds through the membrane against a concentration gradient at the cost of ATP hydrolysis. Substrates of the ABC transporters include lipids, bile acids, xenobiotics, and peptides for antigen presentation. As they transport exogenous and endogenous compounds, they reduce the body load of potentially harmful substances. One by-product of such protective function is that they also eliminate various useful drugs from the body, causing drug resistance. This review is a brief summary of the structure, function, and expression of the important drug resistance-conferring members belonging to three subfamilies of the human ABC family; these are ABCB1 (MDR1/P-glycoprotein of subfamily ABCB), subfamily ABCC (MRPs), and ABCG2 (BCRP of subfamily ABCG), which are expressed in various organs. In the text, the transporter symbol that carries the subfamily name (such as ABCB1, ABCC1, etc.) is used interchangeably with the corresponding original names, such as MDR1P-glycoprotein, MRP1, etc., respectively. Both nomenclatures are maintained in the text because both are still used in the transporter literature. This helps readers relate various names that they encounter in the literature. It now appears that P-glycoprotein, MRP1, MRP2, and BCRP can explain the phenomenon of multidrug resistance in all cell lines analyzed thus far. Also discussed are the gene structure, regulation of expression, and various polymorphisms in these genes. Because genetic polymorphism is thought to underlie interindividual differences, including their response to drugs and other xenobiotics, the importance of polymorphism in these genes is also discussed. JF - International journal of toxicology AU - Choudhuri, Supratim AU - Klaassen, Curtis D AD - Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA. Suratim.Choudhuri@fda.hhs.gov PY - 2006 SP - 231 EP - 259 VL - 25 IS - 4 SN - 1091-5818, 1091-5818 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Neoplasm Proteins KW - P-Glycoprotein KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Biodegradation, Environmental KW - Genes, MDR -- genetics KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68598132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+toxicology&rft.atitle=Structure%2C+function%2C+expression%2C+genomic+organization%2C+and+single+nucleotide+polymorphisms+of+human+ABCB1+%28MDR1%29%2C+ABCC+%28MRP%29%2C+and+ABCG2+%28BCRP%29+efflux+transporters.&rft.au=Choudhuri%2C+Supratim%3BKlaassen%2C+Curtis+D&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2006-07-01&rft.volume=25&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=International+journal+of+toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic variability and the miracle of modern analytical chemistry. AN - 68593045; 16810094 JF - Epidemiology (Cambridge, Mass.) AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. longnec1@niehs.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 350 EP - 351 VL - 17 IS - 4 SN - 1044-3983, 1044-3983 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Humans KW - Cohort Studies KW - Body Mass Index KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Male KW - Female KW - Chemistry Techniques, Analytical -- methods KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68593045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Pharmacokinetic+variability+and+the+miracle+of+modern+analytical+chemistry.&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2006-07-01&rft.volume=17&rft.issue=4&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Epidemiology. 2006 Jul;17(4):352-9 [16755267] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. AN - 68587844; 16805835 AB - Although endogenous cannabinoid systems have been implicated in the modulation of the rewarding effects of abused drugs and food, little is known about the direct effects of endogenous ligands for cannabinoid receptors on brain reward processes. Here we show for the first time that the intravenous administration of anandamide, an endogenous ligand for cannabinoid receptors, and its longer-lasting synthetic analog methanandamide, increase the extracellular dopamine levels in the nucleus accumbens shell of awake, freely moving rats, an effect characteristic of most drugs abused by humans. Anandamide produced two distinctly different effects on dopamine levels: (1) a rapid, transient increase that was blocked by the cannabinoid CB1 receptor antagonist rimonabant, but not by the vanilloid VR1 receptor antagonist capsazepine, and was magnified and prolonged by the fatty acid amide hydrolase (FAAH) enzyme inhibitor, URB597; (2) a smaller delayed and long-lasting increase, not sensitive to CB1, VR1 or FAAH blockade. Both effects were blocked by infusing either tetrodotoxin (TTX, 1 microm) or calcium-free Ringer's solution through the microdialysis probe, demonstrating that they were dependent on the physiologic activation of dopaminergic neurotransmission. Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes. JF - Journal of neurochemistry AU - Solinas, Marcello AU - Justinova, Zuzana AU - Goldberg, Steven R AU - Tanda, Gianluigi AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 408 EP - 419 VL - 98 IS - 2 SN - 0022-3042, 0022-3042 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Cannabinoids KW - Carbamates KW - Endocannabinoids KW - Enzyme Inhibitors KW - Polyunsaturated Alkamides KW - Receptor, Cannabinoid, CB1 KW - TRPV Cation Channels KW - TRPV1 receptor KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Tetrodotoxin KW - 4368-28-9 KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - Calcium KW - SY7Q814VUP KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Carbamates -- pharmacology KW - Animals KW - TRPV Cation Channels -- drug effects KW - Synaptic Transmission -- drug effects KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Cannabinoids -- pharmacology KW - Microdialysis KW - Rats KW - Rats, Sprague-Dawley KW - Benzamides -- pharmacology KW - Calcium -- physiology KW - Data Interpretation, Statistical KW - Tetrodotoxin -- pharmacology KW - Male KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Amidohydrolases -- antagonists & inhibitors KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68587844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Anandamide+administration+alone+and+after+inhibition+of+fatty+acid+amide+hydrolase+%28FAAH%29+increases+dopamine+levels+in+the+nucleus+accumbens+shell+in+rats.&rft.au=Solinas%2C+Marcello%3BJustinova%2C+Zuzana%3BGoldberg%2C+Steven+R%3BTanda%2C+Gianluigi&rft.aulast=Solinas&rft.aufirst=Marcello&rft.date=2006-07-01&rft.volume=98&rft.issue=2&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. AN - 68072888; 16154368 AB - The fluoroquinolones are a class of compounds that comprise a large and expanding group of synthetic antimicrobial agents. Structurally, all fluoroquinolones contain a fluorine molecule at the 6-position of the basic quinolone nucleus. Despite the basic similarity in the core structure of these molecules, their physicochemical properties, pharmacokinetic characteristics and microbial activities can vary markedly across compounds. The first of the fluoroquinolones approved for use in animals, enrofloxacin, was approved in the late 1980s. Since then, five other fluoroquinolones have been marketed for use in animals in the United States, with others currently under investigation. This review focuses on the use of fluoroquinolones within veterinary medicine, providing an overview of the structure-activity relationship of the various members of the group, the clinical uses of fluoroquinolones in veterinary medicine, their pharmacokinetics and potential interspecies differences, an overview of the current understanding of the pharmacokinetic/pharmacodynamic relationships associated with fluoroquinolones, a summary of toxicities that have been associated with this class of compounds, their use in both in human and veterinary species, mechanisms associated with the development of microbial resistance to the fluoroquinolones, and a discussion of fluoroquinolone dose optimization. Although the review contains a large body of basic research information, it is intended that the contents of this review have relevance to both the research scientist and the veterinary medical practitioner. JF - Veterinary journal (London, England : 1997) AU - Martinez, Marilyn AU - McDermott, Patrick AU - Walker, Robert AD - US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 20855, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 10 EP - 28 VL - 172 IS - 1 SN - 1090-0233, 1090-0233 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Veterinary Drugs KW - Index Medicus KW - Animals, Domestic KW - Animals KW - Drug Resistance, Bacterial KW - Drug Approval KW - Legislation, Drug KW - Species Specificity KW - Anti-Bacterial Agents -- therapeutic use KW - Animal Diseases -- drug therapy KW - Fluoroquinolones -- therapeutic use KW - Anti-Bacterial Agents -- pharmacology KW - Fluoroquinolones -- pharmacokinetics KW - Fluoroquinolones -- pharmacology KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68072888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+journal+%28London%2C+England+%3A+1997%29&rft.atitle=Pharmacology+of+the+fluoroquinolones%3A+a+perspective+for+the+use+in+domestic+animals.&rft.au=Martinez%2C+Marilyn%3BMcDermott%2C+Patrick%3BWalker%2C+Robert&rft.aulast=Martinez&rft.aufirst=Marilyn&rft.date=2006-07-01&rft.volume=172&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Veterinary+journal+%28London%2C+England+%3A+1997%29&rft.issn=10900233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-21 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002. AN - 68070008; 16769298 AB - The objective of this study was to compare the current prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and mood, anxiety, and personality disorders among whites, blacks, Native Americans, Asians, and Hispanics in a large representative sample of the US population. Striking mental health disparities were observed in the prevalences of psychiatric disorders, especially among Native Americans. Disparities in psychiatric comorbidity differed from those associated with prevalence. Most significantly, the association between alcohol disorders and personality disorders was significantly greater among Asians relative to whites, blacks, and Native Americans, despite lower prevalences of these disorders among Asians. Taken together, the results of this study highlight the need of future studies that help unravel the risk factors underlying the disparities in both prevalence and comorbidity of psychiatric disorders observed among race-ethnic groups in the United States. JF - Comprehensive psychiatry AU - Huang, Boji AU - Grant, Bridget F AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Chou, S Patricia AU - Saha, Tulshi D AU - Goldstein, Risë B AU - Smith, Sharon M AU - Ruan, W June AU - Pickering, Roger P AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA. HuangBo@mail.nih.gov PY - 2006 SP - 252 EP - 257 VL - 47 IS - 4 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Personality Disorders -- epidemiology KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Alcoholism -- ethnology KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Mental Disorders -- ethnology KW - Substance-Related Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68070008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Race-ethnicity+and+the+prevalence+and+co-occurrence+of+Diagnostic+and+Statistical+Manual+of+Mental+Disorders%2C+Fourth+Edition%2C+alcohol+and+drug+use+disorders+and+Axis+I+and+II+disorders%3A+United+States%2C+2001+to+2002.&rft.au=Huang%2C+Boji%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BChou%2C+S+Patricia%3BSaha%2C+Tulshi+D%3BGoldstein%2C+Ris%C3%AB+B%3BSmith%2C+Sharon+M%3BRuan%2C+W+June%3BPickering%2C+Roger+P&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=47&rft.issue=4&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race/ethnic differences in the prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68046980; 16650344 AB - Very few large national epidemiologic surveys have examined the prevalence of psychiatric disorders among Asians and Native Americans due to small sample sizes. Very little is also known about the co-occurrences between substance use disorders and mood and anxiety disorders among these two minority groups and how their rates compare to Whites, Blacks, and Hispanics. Analyses were based on a large (n = 43093) nationally representative survey of the adult (18+ years), U.S. population supplemented by a group quarters sampling frame. Prevalences and associations of major DSM-IV mood, anxiety and substance use disorders were examined among all major race/ethnic subgroups of the population. Twelve-month rates of most mood, anxiety and substance use disorders were generally greatest among Native Americans and lowest among Asians. For most race/ethnic subgroups, alcohol and drug dependence, but not abuse, were significantly associated with mood disorders. With few exceptions, there were no significant associations between alcohol and drug abuse and anxiety disorders. In contrast, alcohol dependence was associated with most anxiety disorders among Whites, Blacks and Asians, but not among Native Americans. The 12-month prevalence of substance use, mood, and anxiety disorders varied greatly across the five major race/ethnic subgroups of the population. Twelve-month co-occurrence of substance use disorders and mood and anxiety disorders was pervasive among all race/ethnic subgroups. Future research is also needed to understand race/ethnic differentials in prevalence and co-occurrence of these disorders with a particular focus on factors that may give rise to them. JF - Psychological medicine AU - Smith, Sharon M AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Goldstein, Rise AU - Huang, Boji AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 987 EP - 998 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Hispanic Americans KW - Humans KW - European Continental Ancestry Group KW - National Institutes of Health (U.S.) KW - Adult KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - African Continental Ancestry Group KW - Male KW - Comorbidity KW - Prevalence KW - Alcoholism -- epidemiology KW - Ethnic Groups KW - Continental Population Groups KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68046980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Race%2Fethnic+differences+in+the+prevalence+and+co-occurrence+of+substance+use+disorders+and+independent+mood+and+anxiety+disorders%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Smith%2C+Sharon+M%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise%3BHuang%2C+Boji%3BGrant%2C+Bridget+F&rft.aulast=Smith&rft.aufirst=Sharon&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Psychol Med. 2008 Apr;38(4):606 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward an alcohol use disorder continuum using item response theory: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68044782; 16563205 AB - Item response theory (IRT) was used to determine whether the DSM-IV diagnostic criteria for alcohol abuse and dependence are arrayed along a continuum of severity. Data came from a large nationally representative sample of the US population, 18 years and older. A two-parameter logistic IRT model was used to determine the severity and discrimination of each DSM-IV criterion. Differential criterion functioning (DCF) was also assessed across subgroups of the population defined by sex, age and race-ethnicity. All DSM-IV alcohol abuse and dependence criteria, except alcohol-related legal problems, formed a continuum of alcohol use disorder severity. Abuse and dependence criteria did not consistently tap the mildest or more severe end of the continuum respectively, and several criteria were identified as potentially redundant. The drinking in larger amounts or for longer than intended dependence criterion had the greatest discrimination and lowest severity than any other criterion. Although several criteria were found to function differentially between subgroups defined in terms of sex and age, there was evidence that the generalizability and validity of the criterion forming the continuum remained intact at the test score level. DSM-IV diagnostic criteria for alcohol abuse and dependence form a continuum of severity, calling into question the abuse-dependence distinction in the DSM-IV and the interpretation of abuse as a milder disorder than dependence. The criteria tapped the more severe end of the alcohol use disorder continuum, highlighting the need to identify other criteria capturing the mild to intermediate range of the severity. The drinking larger amounts or longer than intended dependence criterion may be a bridging criterion between drinking patterns that incur risk of alcohol use disorder at the milder end of the continuum, with tolerance, withdrawal, impaired control and serious social and occupational dysfunction at the more severe end of the alcohol use disorder continuum. Future IRT and other dimensional analyses hold great promise in informing revisions to categorical classifications and constructing new dimensional classifications of alcohol use disorders based on the DSM and the ICD. JF - Psychological medicine AU - Saha, Tulshi D AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 931 EP - 941 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Diagnosis, Differential KW - Ethnic Groups KW - Humans KW - National Institutes of Health (U.S.) KW - Adult KW - Disease Progression KW - Interviews as Topic KW - Models, Statistical KW - Alcohol Drinking -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68044782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Toward+an+alcohol+use+disorder+continuum+using+item+response+theory%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Saha%2C+Tulshi+D%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of deaeration methods on dissolution testing in aqueous media: a study using a total dissolved gas pressure meter. AN - 68026292; 16732563 AB - Dissolution testing is a critical method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test method temperature, typically 37 degrees C. JF - Journal of pharmaceutical sciences AU - Gao, Zongming AU - Moore, Terry W AU - Doub, William H AU - Westenberger, B J AU - Buhse, Lucinda F AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101, USA. gaoz@cder.fda.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1606 EP - 1613 VL - 95 IS - 7 SN - 0022-3549, 0022-3549 KW - Gases KW - 0 KW - Water KW - 059QF0KO0R KW - Oxygen KW - S88TT14065 KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Solubility KW - Water -- chemistry KW - Temperature KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation KW - Prednisone -- chemistry KW - Gases -- analysis KW - Chemistry, Pharmaceutical -- instrumentation KW - Oxygen -- analysis KW - Chemistry, Pharmaceutical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68026292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Effects+of+deaeration+methods+on+dissolution+testing+in+aqueous+media%3A+a+study+using+a+total+dissolved+gas+pressure+meter.&rft.au=Gao%2C+Zongming%3BMoore%2C+Terry+W%3BDoub%2C+William+H%3BWestenberger%2C+B+J%3BBuhse%2C+Lucinda+F&rft.aulast=Gao&rft.aufirst=Zongming&rft.date=2006-07-01&rft.volume=95&rft.issue=7&rft.spage=1606&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mothers' Work and Child Care AN - 61682227; 200724020 AB - In "Mothers' Work and Child Care': Julia B. Isaacs, director of the Division of Data and Technical Analysis of the Department of Health and Human Services (HHS) Office of Planning, She describes the strengths and weakness of the child care data in the main national surveys. Isaacs also examines the main data sources that HHS uses to measure the availability and quality of child care for low-income families: the Current Population Survey (CPS); the Survey of Income and Program Participation (SIPP); the National Household Education Survey (NHES); the National Survey of America's Families (NSAF); state administrative data collected by the federal government that include aggregate numbers of children receiving subsidies as well as some of the characteristics of those subsidies, such as type of provider and age of child, and state studies of those who have left the welfare rolls (leaver studies). Adapted from the source document. JF - Gender Issues AU - Isaacs, Julia B AD - Office of the Assistant Secretary for Planning and Evaluation (ASPE), U.S. Department of Health and Human Services Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 11 EP - 20 PB - Transaction Periodicals Consortium, Piscataway NJ VL - 23 IS - 3 SN - 1098-092X, 1098-092X KW - Low Income Groups KW - Mothers KW - United States of America KW - Surveys KW - Children KW - Data Quality KW - Child Care Services KW - Social Welfare KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gender+Issues&rft.atitle=Mothers%27+Work+and+Child+Care&rft.au=Isaacs%2C+Julia+B&rft.aulast=Isaacs&rft.aufirst=Julia&rft.date=2006-07-01&rft.volume=23&rft.issue=3&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Gender+Issues&rft.issn=1098092X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-03 N1 - Number of references - 8 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child Care Services; Data Quality; Social Welfare; Mothers; Children; Low Income Groups; Surveys; United States of America ER - TY - JOUR T1 - Commentary on eyler and jeste: practical issues in consent capacity and mental disorders AN - 57250110; 200816580 AB - Comments on the theoretically informed suggestions offered by Lisa T. Eyler & Dilip V. Jeste (2006) for improving the informed consent process & enhancing the ability of persons with reduced mental capacity to provide informed consent. More practical matters deserving empirical consideration are addressed, including developing simpler & more effective ways of assessing consent capacity, understanding the motivations & desired outcomes of the mentally impaired for participating in research, & diagnostic factors that can make decision making about consent more difficult. References. K. Hyatt Stewart [Copyright 2006 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Shore, David AU - Shell, Pamela Hayes AU - Wishnoff, Christine Moretto AD - National Institute of Mental Health (NIMH), Bethesda, MD (a component of the NIH and the US Department of Health and Human Services HHS dshore@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 569 EP - 572 PB - John Wiley & Sons, Chichester UK VL - 24 IS - 4 SN - 0735-3936, 0735-3936 KW - Assessment KW - Comments KW - Informed consent KW - Capacity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Commentary+on+eyler+and+jeste%3A+practical+issues+in+consent+capacity+and+mental+disorders&rft.au=Shore%2C+David%3BShell%2C+Pamela+Hayes%3BWishnoff%2C+Christine+Moretto&rft.aulast=Shore&rft.aufirst=David&rft.date=2006-07-01&rft.volume=24&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.690 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Capacity; Informed consent; Comments; Assessment DO - http://dx.doi.org/10.1002/bsl.690 ER - TY - JOUR T1 - Smoking and Bladder Cancer in Spain: Effects of Tobacco Type, Timing, Environmental Tobacco Smoke, and Gender AN - 20855579; 6994536 AB - We examined the effects of dose, type of tobacco, cessation, inhalation, and environmental tobacco smoke exposure on bladder cancer risk among 1,219 patients with newly diagnosed bladder cancer and 1,271 controls recruited from 18 hospitals in Spain. We used unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the association between bladder cancer risk and various characteristics of cigarette smoking. Current smokers (men: OR, 7.4; 95% CI, 5.3-10.4; women: OR, 5.1; 95% CI, 1.6-16.4) and former smokers (men: OR, 3.8; 95% CI, 2.8-5.3; women: OR, 1.8; 95% CI, 0.5-7.2) had significantly increased risks of bladder cancer compared with nonsmokers. We observed a significant positive trend in risk with increasing duration and amount smoked. After adjustment for duration, risk was only 40% higher in smokers of black tobacco than that in smokers of blond tobacco (OR, 1.4; 95% CI, 0.98-2.0). Compared with risk in current smokers, a significant inverse trend in risk with increasing time since quitting smoking blond tobacco was observed ( greater than or equal to 20 years cessation: OR, 0.2; 95% CI, 0.1-0.9). No trend in risk with cessation of smoking black tobacco was apparent. Compared with men who inhaled into the mouth, risk increased for men who inhaled into the throat (OR, 1.7; 95% CI, 1.1-2.6) and chest (OR, 1.5; 95% CI, 1.1-2.1). Cumulative occupational exposure to environmental tobacco smoke seemed to confer increased risk among female nonsmokers but not among male nonsmokers. After eliminating the effect of cigarette smoking on bladder cancer risk in our study population, the male-to-female incidence ratio decreased from 8.2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens. (Cancer Epidemiol Biomarkers Prev 2006; 15(7):1348-54) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Samanic, Claudine AU - Kogevinas, Manolis AU - Dosemeci, Mustafa AU - Malats, Nuria AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Sala, Maria AU - Lloreta, Josep AU - Tardon, Adonina AU - Rothman, Nathaniel AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1348 EP - 1354 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 7 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts KW - Bioindicators KW - Inhalation KW - Spain KW - Carcinogens KW - Cancer KW - urinary bladder KW - Passive smoking KW - Cigarette smoking KW - Gender KW - Tobacco KW - prevention KW - Occupational exposure KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Smoking+and+Bladder+Cancer+in+Spain%3A+Effects+of+Tobacco+Type%2C+Timing%2C+Environmental+Tobacco+Smoke%2C+and+Gender&rft.au=Samanic%2C+Claudine%3BKogevinas%2C+Manolis%3BDosemeci%2C+Mustafa%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BSala%2C+Maria%3BLloreta%2C+Josep%3BTardon%2C+Adonina%3BRothman%2C+Nathaniel%3BSilverman%2C+Debra+T&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1348&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Bioindicators; urinary bladder; Passive smoking; Gender; Cigarette smoking; prevention; Tobacco; Carcinogens; Occupational exposure; Cancer; Hospitals; Spain ER - TY - JOUR T1 - Food-processing enzymes from recombinant microorganisms-a review AN - 20721816; 6999824 AB - Enzymes are commonly used in food processing and in the production of food ingredients. Enzymes traditionally isolated from culturable microorganisms, plants, and mammalian tissues are often not well-adapted to the conditions used in modern food production methods. The use of recombinant DNA technology has made it possible to manufacture novel enzymes suitable for specific food-processing conditions. Such enzymes may be discovered by screening microorganisms sampled from diverse environments or developed by modification of known enzymes using modern methods of protein engineering or molecular evolution. As a result, several important food-processing enzymes such as amylases and lipases with properties tailored to particular food applications have become available. Another important achievement is improvement of microbial production strains. For example, several microbial strains recently developed for enzyme production have been engineered to increase enzyme yield by deleting native genes encoding extracellular proteases. Moreover, certain fungal production strains have been modified to reduce or eliminate their potential for production of toxic secondary metabolites. In this article, we discuss the safety of microorganisms used as hosts for enzyme-encoding genes, the construction of recombinant production strains, and methods of improving enzyme properties. We also briefly describe the manufacture and safety assessment of enzyme preparations and summarize options for submitting information on enzyme preparations to the US Food and Drug Administration. JF - Regulatory Toxicology and Pharmacology AU - Olempska-Beer, Z S AU - Merker, R I AU - Ditto, MD AU - DiNovi, MJ AD - Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA, zofia.olempskabeer@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 144 EP - 158 PB - Elsevier Inc. VL - 45 IS - 2 SN - 0273-2300, 0273-2300 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts KW - Food processing KW - Triacylglycerol lipase KW - molecular evolution KW - Protein engineering KW - Reviews KW - Microorganisms KW - DNA KW - Enzymes KW - Secondary metabolites KW - Proteinase KW - Food plants KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - A 01330:Food Microbiology KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Food-processing+enzymes+from+recombinant+microorganisms-a+review&rft.au=Olempska-Beer%2C+Z+S%3BMerker%2C+R+I%3BDitto%2C+MD%3BDiNovi%2C+MJ&rft.aulast=Olempska-Beer&rft.aufirst=Z&rft.date=2006-07-01&rft.volume=45&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2006.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Triacylglycerol lipase; molecular evolution; Protein engineering; Reviews; DNA; Microorganisms; Secondary metabolites; Enzymes; Proteinase; Food plants DO - http://dx.doi.org/10.1016/j.yrtph.2006.05.001 ER - TY - JOUR T1 - Populations at Risk Across the Lifespan: Case Reports: Correlates of Public Health Workforce Acceptance of Smallpox Immunization in Virginia AN - 20720133; 6962394 AB - By October 24, 2003, 38,577 of 500,000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Design: Cross-sectional survey, conducted in May 2004. Sample: We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Results: Among nonvaccinees (n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees (n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6-85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1-22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6-81.1). Conclusion: Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed. JF - Public Health Nursing AU - Bryant-Genevier, Marthe AU - Sommer, Sandra AU - McMahon, Ann AU - Ball, Robert AU - Braun, MMiles AD - Marthe Bryant-Genevier, Vaccine Safety Branch, Suite 268 S, HFM-222, CBER-OBE-DE-Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, marthe.bryant-genevier@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 339 EP - 346 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 23 IS - 4 SN - 0737-1209, 0737-1209 KW - Virology & AIDS Abstracts; Risk Abstracts KW - vaccines KW - Motivation KW - bioterrorism KW - Life span KW - Disasters KW - USA, Virginia KW - Vaccination KW - Public health KW - immunization KW - Smallpox KW - safety engineering KW - Health care KW - Case reports KW - Perception KW - Personnel KW - Nursing KW - Vigilance KW - Vaccines KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nursing&rft.atitle=Populations+at+Risk+Across+the+Lifespan%3A+Case+Reports%3A+Correlates+of+Public+Health+Workforce+Acceptance+of+Smallpox+Immunization+in+Virginia&rft.au=Bryant-Genevier%2C+Marthe%3BSommer%2C+Sandra%3BMcMahon%2C+Ann%3BBall%2C+Robert%3BBraun%2C+MMiles&rft.aulast=Bryant-Genevier&rft.aufirst=Marthe&rft.date=2006-07-01&rft.volume=23&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nursing&rft.issn=07371209&rft_id=info:doi/10.1111%2Fj.1525-1446.2006.00570.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 3; references, 9. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smallpox; Motivation; Case reports; Personnel; Perception; bioterrorism; Nursing; Life span; Vigilance; Vaccines; Vaccination; Public health; immunization; vaccines; safety engineering; Health care; Disasters; USA, Virginia DO - http://dx.doi.org/10.1111/j.1525-1446.2006.00570.x ER - TY - JOUR T1 - Absorption, Distribution, and Excretion of Ammonium Perfluorooctanoate (APFO) After Oral Administration to Various Species AN - 20336794; 7692132 AB - Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h (168 h in the rabbit). Substantial sex and species differences in the excretion and disposition of 14C-radioactivity derived from 14C-labeled APFO were observed in this study. The female rat and the male hamster excreted more than 99% of the original 14C activity by 120 h after dosing; conversely, the male rat and the female hamster excreted only 39% and 60% of the original 14C activity, respectively, by 120 h postdosing. The male and female rabbits excreted the 14C activity as rapidly and completely as the female rat and the male hamster, whereas male and female mice excreted only 21% of the original 14C activity by 120 h postdosing. The rapid excretors (female rat, male hamster, and male and female rabbits) contained negligible amounts of 14C in organs and tissues at sacrifice. The slow excretors exhibited the highest 14C concentrations in the blood and liver followed by the kidneys, lungs, and skin. JF - Drug and Chemical Toxicology AU - Hundley, S G AU - Sarrif, A M AU - Kennedy Jr, G L AD - Food and Drug Administration, Center for Drug and Evaluation and Research, Rockville, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 137 EP - 145 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 29 IS - 2 SN - 0148-0545, 0148-0545 KW - Toxicology Abstracts KW - Blood KW - Ammonium KW - Skin KW - Lung KW - Kidney KW - Liver KW - Oral administration KW - Excretion KW - Disposition KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20336794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Chemical+Toxicology&rft.atitle=Absorption%2C+Distribution%2C+and+Excretion+of+Ammonium+Perfluorooctanoate+%28APFO%29+After+Oral+Administration+to+Various+Species&rft.au=Hundley%2C+S+G%3BSarrif%2C+A+M%3BKennedy+Jr%2C+G+L&rft.aulast=Hundley&rft.aufirst=S&rft.date=2006-07-01&rft.volume=29&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Drug+and+Chemical+Toxicology&rft.issn=01480545&rft_id=info:doi/10.1080%2F01480540600561361 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ammonium; Blood; Skin; Lung; Oral administration; Liver; Kidney; Disposition; Excretion DO - http://dx.doi.org/10.1080/01480540600561361 ER - TY - JOUR T1 - Human NK cells can lyse porcine endothelial cells independent of their expression of Gal alpha (1,3)-Gal and killing is enhanced by activation of either effector or target cells AN - 20234438; 6963277 AB - Background:Xenotransplantation of pig organs may provide an approach to alleviate the severe shortage of human organs. Natural antibodies against Gal alpha (1,3)-Gal ( alpha Gal) epitopes cause hyperacute rejection of pig organs in primates. However, evidence for the role of alpha Gal in the natural killer (NK) cell-mediated xenoresponse has been contradictory. Methods:We investigated the recognition of alpha Gal by human NK cells using endo- beta -galactosidase C, an enzyme that cleaves alpha Gal, and endothelial cells (EC) from alpha 1,3-galactosyltransferase null pigs that do not synthesize alpha Gal. Endo- beta -galactosidase C treatment variably reduced the susceptibility of porcine EC to lysis by fresh human NK cells. Results:Removal of alpha Gal from porcine EC using endo- beta -galactosidase C, produced variable results, i.e. cytotoxicity was decreased in half of the human NK cell donors tested. The two EC strains from alpha Gal-/- pigs were marginally, and not significantly, less susceptible to lysis by naive human NK cells compared with alpha Gal-expressing cells obtained from animals from the same herd, but these differences were not statistically significant (P > 0.10). Treatment of porcine EC with recombinant human tumor necrosis factor (TNF)- alpha , which is known to activate porcine EC, enhanced the susceptibility of all target cells to lysis by fresh human NK cells. Surface expression of MHC or adhesion molecules on alpha Gal-/- cells, compared with wild type cells, showed no consistent difference in either MHC or adhesion molecules CD106 (VCAM-1), CD31 (PECAM) or CD62E (E-selectin), either with or without TNF- alpha stimulation, that could explain the differential susceptibility to lysis. Strikingly, all alpha Gal-/- and wild type EC exhibited similar susceptibility to human NK cells that had been cultured for 5 days with or without interleukin-2. Conclusions:These findings demonstrate that human NK cells can kill porcine targets in the absence of alpha Gal, and donor variability plays a major role in whether alpha Gal has a role in determining susceptibility of porcine EC to lysis. Moreover, susceptibility to lysis of alpha Gal null EC is enhanced to the level of wild type EC by activation of either effector or target cells. Elimination of alpha Gal alone from source pigs will be insufficient to circumvent the NK cell mediated destruction of porcine EC. JF - Xenotransplantation AU - Horvath-Arcidiacono, Judith A AU - Porter, Cynthia M AU - Bloom, Eda T AD - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA, bloom@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 318 EP - 327 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 13 IS - 4 SN - 0908-665X, 0908-665X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 2 KW - Statistical analysis KW - Natural killer cells KW - Enzymes KW - Major histocompatibility complex KW - Primates KW - Effector cells KW - Endothelial cells KW - vascular cell adhesion molecule 1 KW - Cytotoxicity KW - Antibodies KW - Xenografts KW - Tumor necrosis factor- alpha KW - Epitopes KW - E-selectin KW - Cell adhesion molecules KW - W 30925:Genetic Engineering KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Human+NK+cells+can+lyse+porcine+endothelial+cells+independent+of+their+expression+of+Gal+alpha+%281%2C3%29-Gal+and+killing+is+enhanced+by+activation+of+either+effector+or+target+cells&rft.au=Horvath-Arcidiacono%2C+Judith+A%3BPorter%2C+Cynthia+M%3BBloom%2C+Eda+T&rft.aulast=Horvath-Arcidiacono&rft.aufirst=Judith&rft.date=2006-07-01&rft.volume=13&rft.issue=4&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2006.00316.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 6. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 2; Natural killer cells; Statistical analysis; Major histocompatibility complex; Enzymes; Effector cells; Endothelial cells; vascular cell adhesion molecule 1; Antibodies; Cytotoxicity; Tumor necrosis factor- alpha; Xenografts; Cell adhesion molecules; E-selectin; Epitopes; Primates DO - http://dx.doi.org/10.1111/j.1399-3089.2006.00316.x ER - TY - JOUR T1 - Contribution of interferon- beta to the immune activation induced by double-stranded DNA AN - 20193763; 6959835 AB - Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial-viral factors. Current findings indicate that interferon- beta (IFN- beta ) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN- beta ) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA. JF - Immunology AU - Shirota, Hidekazu AU - Ishii, Ken J AU - Takakuwa, Hiroki AU - Klinman, Dennis M AD - Section of Retroviral Immunology, klinman@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 302 EP - 310 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 118 IS - 3 SN - 0019-2805, 0019-2805 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Macrophages KW - beta -Interferon KW - Chemokines KW - MyD88 protein KW - Infection KW - DNA-dependent protein kinase KW - Cell activation KW - Costimulator KW - Dendritic cells KW - Cytoplasm KW - Cytokines KW - Immune response KW - Antigen-presenting cells KW - V 22320:Replication KW - N 14845:Miscellaneous KW - F 06960:Molecular Immunology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Contribution+of+interferon-+beta+to+the+immune+activation+induced+by+double-stranded+DNA&rft.au=Shirota%2C+Hidekazu%3BIshii%2C+Ken+J%3BTakakuwa%2C+Hiroki%3BKlinman%2C+Dennis+M&rft.aulast=Shirota&rft.aufirst=Hidekazu&rft.date=2006-07-01&rft.volume=118&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/10.1111%2Fj.1365-2567.2006.02367.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 7; tables, 1; references, 35. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Macrophages; Chemokines; MyD88 protein; Infection; DNA-dependent protein kinase; Cell activation; Dendritic cells; Costimulator; Cytoplasm; Cytokines; Antigen-presenting cells; Immune response DO - http://dx.doi.org/10.1111/j.1365-2567.2006.02367.x ER - TY - JOUR T1 - Molecular characterization of cytochrome P450 genes in the polycyclic aromatic hydrocarbon degrading Mycobacterium vanbaalenii PYR-1 AN - 20001294; 7240895 AB - Mycobacterium vanbaalenii PYR-1 has the ability to degrade low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs). In addition to dioxygenases, cytochrome P450 monooxygenases have been implicated in PAH degradation. Three cytochrome P450 genes, cyp151 (pipA), cyp150, and cyp51, were detected and amplified by polymerase chain reaction from M. vanbaalenii PYR-1. The complete sequence of these genes was determined. The translated putative proteins were greater than or equal to 80% identical to other GenBank-listed mycobacterial CYP151, CYP150, and CYP51. Genes pipA and cyp150 were cloned, and the proteins partially expressed in Escherchia coli as soluble heme-containing cytochrome P450s that exhibited a characteristic peak at 450 nm in reduced carbon monoxide difference spectra. Monooxygenation metabolites of pyrene, dibenzothiophene, and 7-methylbenz[ alpha ]anthracene were detected in whole cell biotransformations, with E. coli expressing pipA or cyp150 when analyzed by gas chromatography/mass spectrometry. The cytochrome P450 inhibitor metyrapone strongly inhibited the S-oxidation of dibenzothiophene. Thirteen other Mycobacterium strains were screened for the presence of pipA, cyp150, and cyp51 genes, as well as the initial PAH dioxygenase (nidA and nidB). The results indicated that many of the Mycobacterium spp. surveyed contain both monooxygenases and dioxygenases to degrade PAHs. Our results provide further evidence for the diverse enzymatic capability of Mycobacterium spp. to metabolize polycylic aromatic hydrocarbons. JF - Applied Microbiology and Biotechnology AU - Brezna, Barbara AU - Kweon, Ohgew AU - Stingley, Robin L AU - Freeman, James P AU - Khan, Ashraf A AU - Polek, Bystrik AU - Jones, Richard C AU - Cerniglia, Carl E AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, ccerniglia@nctr.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 522 EP - 532 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 71 IS - 4 SN - 0175-7598, 0175-7598 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Pipa KW - Mycobacterium vanbaalenii KW - Polycyclic aromatic hydrocarbons KW - Cytochrome P450 monooxygenase KW - Biodegradation KW - monooxygenase KW - Mycobacterium KW - Thioxanthene KW - biotransformation KW - Metabolites KW - Pyrene KW - Mass spectroscopy KW - Carbon monoxide KW - Gas chromatography KW - Escherichia coli KW - Aromatic hydrocarbons KW - Polymerase chain reaction KW - Cytochrome P450 KW - Dioxygenase KW - Dibenzothiophene KW - J 02310:Genetics & Taxonomy KW - W 30950:Waste Treatment & Pollution Clean-up KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Molecular+characterization+of+cytochrome+P450+genes+in+the+polycyclic+aromatic+hydrocarbon+degrading+Mycobacterium+vanbaalenii+PYR-1&rft.au=Brezna%2C+Barbara%3BKweon%2C+Ohgew%3BStingley%2C+Robin+L%3BFreeman%2C+James+P%3BKhan%2C+Ashraf+A%3BPolek%2C+Bystrik%3BJones%2C+Richard+C%3BCerniglia%2C+Carl+E&rft.aulast=Brezna&rft.aufirst=Barbara&rft.date=2006-07-01&rft.volume=71&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-005-0190-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytochrome P450 monooxygenase; Polycyclic aromatic hydrocarbons; monooxygenase; Biodegradation; Thioxanthene; biotransformation; Metabolites; Pyrene; Mass spectroscopy; Carbon monoxide; Gas chromatography; Polymerase chain reaction; Aromatic hydrocarbons; Cytochrome P450; Dioxygenase; Dibenzothiophene; Pipa; Mycobacterium vanbaalenii; Mycobacterium; Escherichia coli DO - http://dx.doi.org/10.1007/s00253-005-0190-8 ER - TY - JOUR T1 - The Defined Combination of Growth Factors Controls Generation of Long-Term-Replicating Islet Progenitor-Like Cells from Cultures of Adult Mouse Pancreas AN - 19975784; 6999344 AB - Application of pancreatic islet transplantation to treatment of diabetes is severely hampered by the inadequate islet supply. This problem could in principle be overcome by generating islet cells from adult pancreas in vitro. Although it is possible to obtain replicating cells from cultures of adult pancreas, these cells, when significantly expanded in vitro, progressively lose pancreatic-specific gene expression, including that of a "master" homeobox transcription factor Pdx1. Here we show for the first time that long-term proliferating islet progenitor-like cells (IPLCs) stably expressing high levels of Pdx1 and other genes that control early pancreatic development can be derived from cultures of adult mouse pancreas under serum-free defined culture conditions. Moreover, we show that cells derived thus can be maintained in continuous culture for at least 6 months without any substantial loss of early pancreatic phenotype. Upon growth factor withdrawal, the IPLCs organize into cell clusters and undergo endocrine differentiation of various degrees in a line-dependent manner. We propose that our experimental strategy will provide a framework for developing efficient approaches for ex vivo expansion of islet cell mass. JF - Stem Cells AU - Ta, Malancha AU - Choi, Yong AU - Atouf, Fouad AU - Park, Cheol Hong AU - Lumelsky, Nadya AD - Islet and Autoimmunity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1738 EP - 1749 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Transplantation KW - Pancreas KW - Homeobox KW - Islet cells KW - Islets of Langerhans KW - Cell culture KW - Diabetes mellitus KW - Gene expression KW - Differentiation KW - Stem cells KW - Continuous culture KW - Transcription factors KW - Allografts KW - Growth factors KW - Pancreatic islet transplantation KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Defined+Combination+of+Growth+Factors+Controls+Generation+of+Long-Term-Replicating+Islet+Progenitor-Like+Cells+from+Cultures+of+Adult+Mouse+Pancreas&rft.au=Ta%2C+Malancha%3BChoi%2C+Yong%3BAtouf%2C+Fouad%3BPark%2C+Cheol+Hong%3BLumelsky%2C+Nadya&rft.aulast=Ta&rft.aufirst=Malancha&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1738&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transplantation; Pancreas; Cell culture; Islets of Langerhans; Islet cells; Homeobox; Gene expression; Diabetes mellitus; Differentiation; Stem cells; Continuous culture; Transcription factors; Allografts; Pancreatic islet transplantation; Growth factors ER - TY - JOUR T1 - Identification and Functional Analysis of Candidate Genes Regulating Mesenchymal Stem Cell Self-Renewal and Multipotency AN - 19959893; 6999341 AB - Adult human mesenchymal stem cells (hMSCs) possess multilineage differentiation potential, and differentiated hMSCs have recently been shown to have the ability to transdifferentiate into other lineages. However, the molecular signature of hMSCs is not well-known, and the mechanisms regulating their self-renewal, differentiation, and transdifferentiation are not completely understood. In this study, we demonstrate that fully differentiated hMSCs could dedifferentiate, a likely critical step for transdifferentiation. By comparing the global gene expression profiles of undifferentiated, differentiated, and dedifferentiation cells in three mesenchymal lineages (osteogenesis, chondrogenesis, and adipogenesis), we identified a number of "stemness" and "differentiation" genes that might be essential to maintain adult stem cell multipotency as well as to drive lineage-specific commitment. These genes include those that encode cell surface molecules, as well as components of signaling pathways. These genes may be valuable for developing methods to isolate, enrich, and purify homogeneous population of hMSCs and/or maintain and propagate hMSCs as well as guide or regulate their differentiation for gene and cell-based therapy. Using small interfering RNA gene inactivation, we demonstrate that five genes (actin filament-associated protein, frizzled 7, dickkopf 3, protein tyrosine phosphatase receptor F, and RAB3B) promote cell survival without altering cell proliferation, as well as exhibiting different effects on the commitment of hMSCs into multiple mesenchymal lineages. JF - Stem Cells AU - Song, Lin AU - Webb, Nicole E AU - Song, Yingjie AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1707 EP - 1718 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Cell surface KW - Frizzled protein KW - Protein-tyrosine-phosphatase KW - Gene expression KW - Stem cells KW - siRNA KW - Actin KW - Cell proliferation KW - Mesenchyme KW - adipogenesis KW - Chondrogenesis KW - Osteogenesis KW - Signal transduction KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Identification+and+Functional+Analysis+of+Candidate+Genes+Regulating+Mesenchymal+Stem+Cell+Self-Renewal+and+Multipotency&rft.au=Song%2C+Lin%3BWebb%2C+Nicole+E%3BSong%2C+Yingjie%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1707&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Cell surface; Frizzled protein; Protein-tyrosine-phosphatase; Gene expression; Stem cells; siRNA; Actin; adipogenesis; Mesenchyme; Cell proliferation; Signal transduction; Osteogenesis; Chondrogenesis ER - TY - JOUR T1 - High Level Expression and Characterization of the Cyclophilin B Gene from the Anaerobic Fungus Orpinomyces sp. Strain PC-2 AN - 19794516; 7659566 AB - Cyclophilins are an evolutionarily conserved family of peptidyl-prolyl cis-trans isomerases (PPIases). A cyclophilin B (cypB) gene from the anaerobic fungus Orpinomyces sp. strain PC-2 was cloned and overexpressed in Escherichia coli. It was expressed as an amino-terminal 6 x His-tagged recombinant protein to facilitate purification. Highly purified protein (26.5 kDa) was isolated by two chromatographic steps involving affinity and gel filtration for biochemical studies of the enzyme. The recombinant CypB displayed PPIase activity with a kcat/Km of 8.9 x 106 M-1 s-1 at 10 degree C and pH 7.8. It was inhibited by cyclosporin A (CsA) with an IC50 of 23.5 nM, similar to those of the native protein and other cyclophilin B enzymes from animals. Genomic DNA analysis of cypB revealed that it was present as a single copy in Orpinomyces PC-2 and contained two introns, indicating it has a eukaryotic origin. It is one of the most heavily interrupted genes with intron sequences found in anaerobic fungi. The three-dimensional model of Orpinomyces PC-2 CypB was predicted with a homology modeling approach using the Swiss-Model Protein Modeling Server and three dimensional structure of human CypB as a template. The overall architecture of the CypB molecule is very similar to that of human CypB. JF - Protein & Peptide Letters AU - Chen, Huizhong AU - Li, Xin-Liang AU - Xu, Haiyan AU - Ljungdahl, Lars G AU - Cerniglia, Carl E AD - Division of Microbiology,National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd.,Jefferson, AR 72079, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 727 EP - 732 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 13 IS - 7 SN - 0929-8665, 0929-8665 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Cyclophilin B KW - PPIase KW - Orpinomyces sp. strain PC-2 KW - characterization KW - introns KW - gene analysis KW - Fungi KW - Enzymes KW - protein purification KW - Models KW - Filtration KW - Orpinomyces KW - Homology KW - Peptidylprolyl isomerase KW - Escherichia coli KW - DNA KW - Introns KW - genomics KW - Cyclosporin A KW - pH effects KW - Evolution KW - J 02410:Animal Diseases KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+%26+Peptide+Letters&rft.atitle=High+Level+Expression+and+Characterization+of+the+Cyclophilin+B+Gene+from+the+Anaerobic+Fungus+Orpinomyces+sp.+Strain+PC-2&rft.au=Chen%2C+Huizhong%3BLi%2C+Xin-Liang%3BXu%2C+Haiyan%3BLjungdahl%2C+Lars+G%3BCerniglia%2C+Carl+E&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2006-07-01&rft.volume=13&rft.issue=7&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Protein+%26+Peptide+Letters&rft.issn=09298665&rft_id=info:doi/10.2174%2F092986606777790511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fungi; Enzymes; protein purification; Models; Filtration; Peptidylprolyl isomerase; Homology; Introns; DNA; Cyclosporin A; genomics; pH effects; Evolution; Orpinomyces; Escherichia coli DO - http://dx.doi.org/10.2174/092986606777790511 ER - TY - JOUR T1 - Diffusion of limonene in polyethylene AN - 19750134; 8681659 AB - Diffusion coefficients of limonene in various linear low-density polyethylene (LLDPE) and low-density polyethylene (LDPE) resins have been determined from sorption data using a thermogravimetric methodology. From these data, one can determine whether polymer synthesis parameters such as the choice of catalytic process or co-monomer result in substantial differences in how much food packaging additives might migrate to food. For example, LLDPE is currently manufactured using either one of two distinct catalytic processes: Ziegler-Natta (ZN) and metallocene, a single-site catalyst. ZN catalysis is a heterogeneous process that has dominated polyolefin synthesis over the last half-century. It involves a transition metal compound containing a metal-carbon bond that can handle repeated insertion of olefin units. In contrast, metallocene catalysis has fewer than 20 years of history, but has generated much interest due to its ability to produce highly stereospecific polymers at a very high yield. In addition to high stereospecificity, metallocene-catalysed polymers are significantly lower in polydispersity than traditional ZN counterparts. Absorption and desorption testing of heat-pressed films made from LLDPE and LDPE resins of varying processing parameters indicates that diffusion coefficients of limonene in these resins do not change substantially. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Limm, W AU - Begley, T H AU - Lickly, T AU - Hentges, S G AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (HFS-245), College Park, MD 20740, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 738 EP - 746 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 23 IS - 7 SN - 0265-203X, 0265-203X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Absorption KW - Diffusion KW - Packaging KW - Sorption KW - Metals KW - Resins KW - Risk assessment KW - Food additives KW - Catalysts KW - Desorption KW - Polymers KW - Additives KW - Catalysis KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19750134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Diffusion+of+limonene+in+polyethylene&rft.au=Limm%2C+W%3BBegley%2C+T+H%3BLickly%2C+T%3BHentges%2C+S+G&rft.aulast=Limm&rft.aufirst=W&rft.date=2006-07-01&rft.volume=23&rft.issue=7&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030600654408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Polymers; Diffusion; Resins; Absorption; Catalysis; Metals; Food additives; Packaging; Risk assessment; Desorption; Sorption; Additives; Historical account; Catalysts DO - http://dx.doi.org/10.1080/02652030600654408 ER - TY - JOUR T1 - Bacillus tequilensis sp. nov., isolated from a 2000-year-old Mexican shaft-tomb, is closely related to Bacillus subtilis AN - 19555088; 7271292 AB - A Gram-positive, spore-forming bacillus was isolated from a sample taken from an approximately 2000-year-old shaft-tomb located in the Mexican state of Jalisco, near the city of Tequila. Tentative identification using conventional biochemical analysis consistently identified the isolate as Bacillus subtilis. DNA isolated from the tomb isolate, strain 10b super(T), and closely related species was used to amplify a Bacillus-specific portion of the highly conserved 16S rRNA gene and an internal region of the superoxide dismutase gene (sodA sub(int)). Trees derived from maximum-likelihood methods applied to the sodA sub(int) sequences yielded non-zero branch lengths between strain 10b super(T) and its closest relative, whereas a comparison of a Bacillus-specific 546 bp amplicon of the 16S rRNA gene demonstrated 99 % similarity with B. subtilis. Although the 16S rRNA gene sequences of strain 10b super(T) and B. subtilis were 99 % similar, PFGE of NotI-digested DNA of strain 10b super(T) revealed a restriction profile that was considerably different from those of B. subtilis and other closely related species. Whereas qualitative differences in whole-cell fatty acids were not observed, significant quantitative differences were found to exist between strain 10b super(T) and each of the other closely related Bacillus species examined. In addition, DNA-DNA hybridization studies demonstrated that strain 10b super(T) had a relatedness value of less than 70 % with B. subtilis and other closely related species. Evidence from the sodA sub(int) sequences, whole-cell fatty acid profiles and PFGE analysis, together with results from DNA-DNA hybridization studies, justify the classification of strain 10b super(T) as representing a distinct species, for which the name Bacillus tequilensis sp. nov. is proposed. The type strain is 10b super(T) (=ATCC BAA-819 super(T)=NCTC 13306 super(T)). The GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequence of strain 10b super(T) is AY197613 and those for the sodA sub(int) gene sequences of strain 10b super(T), Bacillus amyloliquefaciens ATCC 23842, Bacillus atrophaeus NRRL NRS-213 super(T), Paenibacillus lentimorbus ATCC 14707 super(T), Bacillus mojavensis NRRL B-14698 super(T) and Bacillus vallismortis NRRL B-14890 super(T) are AY197614-AY197619, respectively. A comparison of phenotypic characteristics of Bacillus tequilensis sp. nov. 10b super(T) and other Bacillus species is available as supplementary material in IJSEM Online. JF - International Journal of Systematic and Evolutionary Microbiology AU - Gatson, Joshua W AU - Benz, Bruce F AU - Chandrasekaran, Chitra AU - Satomi, Masataka AU - Venkateswaran, Kasthuri AU - Hart, Mark E AD - Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA, mark.hart@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1475 EP - 1484 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 56 IS - 7 SN - 1466-5026, 1466-5026 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Classification KW - Superoxide dismutase KW - Nucleotide sequence KW - Paenibacillus lentimorbus KW - Fatty acids KW - DNA KW - Biochemical analysis KW - Bacillus amyloliquefaciens KW - rRNA 16S KW - Bacillus tequilensis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19555088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.atitle=Bacillus+tequilensis+sp.+nov.%2C+isolated+from+a+2000-year-old+Mexican+shaft-tomb%2C+is+closely+related+to+Bacillus+subtilis&rft.au=Gatson%2C+Joshua+W%3BBenz%2C+Bruce+F%3BChandrasekaran%2C+Chitra%3BSatomi%2C+Masataka%3BVenkateswaran%2C+Kasthuri%3BHart%2C+Mark+E&rft.aulast=Gatson&rft.aufirst=Joshua&rft.date=2006-07-01&rft.volume=56&rft.issue=7&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.issn=14665026&rft_id=info:doi/10.1099%2Fijs.0.63946-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Classification; Superoxide dismutase; Nucleotide sequence; DNA; Fatty acids; Biochemical analysis; rRNA 16S; Bacillus subtilis; Paenibacillus lentimorbus; Bacillus amyloliquefaciens; Bacillus tequilensis DO - http://dx.doi.org/10.1099/ijs.0.63946-0 ER - TY - JOUR T1 - A Numerical and Experimental Investigation of Crystalline Silica Exposure Control During Tuck Pointing AN - 19481447; 7178798 AB - National Institute for Occupational Safety and Health researchers investigated control measures for the removal of mortar between bricks, using a grinder. This task, "tuck pointing," is associated with crystalline silica exposures many times greater than the permissible exposure limit enforced by the Occupational Safety and Health Administration. Previous studies showed that local exhaust ventilation (LEV) of the grinding wheel through a shroud was often ineffective. Tuck pointing occurs on a scaffold. For practical purposes, this limits the size and power of the LEV system. Thus, the goal of this study was to develop a recommended flow rate for exposure control. Flow induced by the rotating grinding wheel, flow induced by the mortar particle stream, and particle momentum are potential control challenges. Computational fluid dynamic (CFD) simulation of the grinder, supported by some experimental measurements, showed the relative importance of these factors through varying parameters and tracking particles. In a simulation of the shroud and grinding wheel, with the wheel inserted to a cutting depth of 0.750 inch flush into the brick wall, -0.461 cubic feet per meter (0.461 into the exhaust takeoff) was induced by the rotating wheel. The more realistic situation of the wheel in a cut in the wall 1.25 inches deep (forming a trench circumferentially 0.500 inch below the wheel edge) induced an airflow of 8.24 cfm out of the shroud exhaust. Experimental measurements taken for validation were 7.3% lower than the CFD value. The trench effect disappeared when a stream of 10- mu m particles was launched from the grinding wheel edge, as the simulations with and without the trench had nearly identical induced flow rates, 10.8 cfm and 10.9 cfm. We thus interpreted the particle stream as more important than the wheel in inducing flow. This insight was possible because of the power of CFD, compared to intuition and classical boundary layer analysis. In this situation of no forced exhaust, all particles escaped through the gap between the shroud edge and the brick wall into the worker's environment. Experiments and simulations indicated that approximately 85 cfm was required for good control of silica exposure, clearly demonstrating that the exhaust rate must accomplish much more than balancing the induced flow. The simulations showed that the exhaust must create a vacuum in the shroud sufficient to bend the particle paths into the shroud. In the simulations, stopping the particle stream through collision (effectively removing or reducing the "daylight" between the wall and shroud) greatly lessened the required flow rate. This is difficult in practice because the gaps between the shroud and the brick and between bricks create escape paths. JF - Journal of Occupational and Environmental Hygiene AU - Heitbrink, W AU - Bennett, J AD - NIOSH-DART/EPHB, 4676 Columbia Parkway, MS R5, Cincinnati, OH 45226-1998, USA, jbennett@cdc.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 366 EP - 378 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Simulation KW - Vacuum KW - Particulates KW - Computer applications KW - Streams KW - Flow rates KW - scaffolds KW - Exhausts KW - Silica KW - silica KW - Boundary layers KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19481447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Numerical+and+Experimental+Investigation+of+Crystalline+Silica+Exposure+Control+During+Tuck+Pointing&rft.au=Heitbrink%2C+W%3BBennett%2C+J&rft.aulast=Heitbrink&rft.aufirst=W&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600762057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Silica; Ventilation; Boundary layers; Vacuum; Computer applications; Streams; scaffolds; Occupational exposure; Environmental hygiene; Exhausts; silica; Simulation; Particulates; Flow rates DO - http://dx.doi.org/10.1080/15459620600762057 ER - TY - JOUR T1 - The impact of affect and frequency on lexical decision: The role of the amygdala and inferior frontal cortex AN - 19446772; 6931190 AB - The current study used event-related fMRI to examine BOLD responses associated with two factors that behaviorally determine speed of lexical decision: frequency and emotion. Thirteen healthy adults performed a visual lexical decision task, discriminating between words and orthographically and phonologically legal nonwords. The study involved a 2 (Frequency: high and low) x 3 (Emotional arousal: highly negative, mildly negative, and neutral words) design with word categories matched for number of letters and concreteness. There were significant main effects for both frequency and emotion in lexical decision reaction times but no significant interaction. Negative word lexical decisions were associated with increased activation in bilateral amygdala and middle temporal cortex as well as rostral anterior and posterior cingulate cortex. Low-frequency word lexical decisions, relative to high-frequency word lexical decisions, were associated with increased bilateral activity in inferior frontal cortex. Inferior frontal cortex activation was particularly low during lexical decision for high-frequency emotional words but significant for high- frequency neutral emotional words. We suggest that this is because the semantic representation of high-frequency emotional words may receive sufficient additional augmentation via the reciprocal activation from the amygdala such that selective augmentation by inferior frontal cortex to achieve lexical decision is unnecessary. JF - NeuroImage AU - Nakic, Marina AU - Smith, Bruce W AU - Busis, Sarah AU - Vythilingam, Meena AU - Blair, RJames R AD - Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, nakicm@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1752 EP - 1761 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Emotions KW - Arousal KW - Functional magnetic resonance imaging KW - Cortex (frontal) KW - Cortex (temporal) KW - Cortex (cingulate) KW - Decision making KW - Reaction time task KW - Cortex (visual) KW - Amygdala KW - Language KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+impact+of+affect+and+frequency+on+lexical+decision%3A+The+role+of+the+amygdala+and+inferior+frontal+cortex&rft.au=Nakic%2C+Marina%3BSmith%2C+Bruce+W%3BBusis%2C+Sarah%3BVythilingam%2C+Meena%3BBlair%2C+RJames+R&rft.aulast=Nakic&rft.aufirst=Marina&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1752&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Language; Emotions; Cortex (frontal); Cortex (cingulate); Cortex (temporal); Amygdala; Cortex (visual); Reaction time task; Arousal; Decision making; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2006.02.022 ER - TY - JOUR T1 - Brain abnormalities in human obesity: A voxel-based morphometric study AN - 19446314; 6931161 AB - Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m super(2)) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m super(2)) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P - 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post- central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity. JF - NeuroImage AU - Pannacciulli, Nicola AU - Del Parigi, Angelo AU - Chen, Kewei AU - Le, Duc Son NT AU - Reiman, Eric M AU - Tataranni, Pietro A AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N. 16th St., Rm. 5-28, Phoenix, AZ 85016, USA, nicolap@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1419 EP - 1425 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - Physical Education Index; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Alzheimer's disease KW - Anatomy KW - Evaluation KW - Body weight KW - Weight KW - Sex KW - Handedness KW - Brain KW - Morphometry KW - Adipose tissue KW - Body fat KW - Body mass index KW - Substantia grisea KW - Body mass KW - Magnetic resonance imaging KW - Techniques KW - Putamen KW - Reward KW - Risk factors KW - Reinforcement KW - Brain architecture KW - frontal gyrus KW - Obesity KW - Taste KW - Neurodegenerative diseases KW - operculum KW - Scanning KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Brain+abnormalities+in+human+obesity%3A+A+voxel-based+morphometric+study&rft.au=Pannacciulli%2C+Nicola%3BDel+Parigi%2C+Angelo%3BChen%2C+Kewei%3BLe%2C+Duc+Son+NT%3BReiman%2C+Eric+M%3BTataranni%2C+Pietro+A&rft.aulast=Pannacciulli&rft.aufirst=Nicola&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.01.047 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Obesity; Brain; Alzheimer's disease; Evaluation; Scanning; Techniques; Reward; Risk factors; Handedness; Sex; Weight; Body mass; Magnetic resonance imaging; Neurodegenerative diseases; Body fat; Brain architecture; Body mass index; Putamen; Taste; Reinforcement; operculum; frontal gyrus; Anatomy; Morphometry; Adipose tissue; Body weight; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2006.01.047 ER - TY - JOUR T1 - Fabrication and characterization of six electrospun poly( alpha -hydroxy ester)- based fibrous scaffolds for tissue engineering applications AN - 19439289; 6868568 AB - The most common synthetic biodegradable polymers being investigated for tissue engineering applications are FDA approved, clinically used poly( alpha - hydroxy esters). To better assess the applicability of the electrospinning technology for scaffold fabrication, six commonly used poly( alpha -hydroxy esters) were used to prepare electrospun fibrous scaffolds, and their physical and biological properties were also characterized. Our results suggest that specific, optimized fabrication parameters are required for each polymer to produce scaffolds that consist of uniform structures morphologically similar to native extracellular matrix. Scanning electron microscopy (SEM) revealed a highly porous, three-dimensional structure for all scaffolds, with average fiber diameter ranging from 300 nm to 1.5 mu m, depending on the polymer type used. The poly(glycolic acid) (PGA) and poly(d,l-lactic-co-glycolic acid 50:50) (PLGA5050) fibrous structures were mechanically stiffest, whereas the poly(l- lactic acid) (PLLA) and poly( epsilon -caprolactone) (PCL) scaffolds were most compliant. Upon incubation in physiological solution, severe structural destruction due to polymer degradation was found in the PGA, poly(d,l-lactic acid) (PDLLA), PLGA5050, and poly(d,l-lactic-co-glycolic acid 85:15) (PLGA8515) fibrous scaffolds, whereas PLLA and PCL fibrous scaffolds maintained a robust scaffold structure during the same time period, based on macroscopic and SEM observations. In addition, PLLA scaffolds supported the highest rate of proliferation of seeded cells (chondrocytes and mesenchymal stem cells) than other polymeric scaffolds. Our findings showed that PLLA and PCL based fibrous scaffolds exhibited the most optimal structural integrity and supported desirable cellular response in culture, suggesting that such scaffolds may be promising candidate biomaterials for tissue engineering applications. JF - Acta Biomaterialia AU - Li, Wan-Ju AU - Cooper, James A AU - Mauck, Robert L AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Room 1523, Bldg 50, MSC 8022, Department of Health and Human Services, Bethesda, MD 20892, United States, tuanr@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 377 EP - 385 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 2 IS - 4 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Scanning electron microscopy KW - Chondrocytes KW - polylactic acid KW - Cell culture KW - Esters KW - Tissue engineering KW - scaffolds KW - Fibers KW - Stem cells KW - Extracellular matrix KW - Lactic acid KW - Biomaterials KW - Cell proliferation KW - Mesenchyme KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Fabrication+and+characterization+of+six+electrospun+poly%28+alpha+-hydroxy+ester%29-+based+fibrous+scaffolds+for+tissue+engineering+applications&rft.au=Li%2C+Wan-Ju%3BCooper%2C+James+A%3BMauck%2C+Robert+L%3BTuan%2C+Rocky+S&rft.aulast=Li&rft.aufirst=Wan-Ju&rft.date=2006-07-01&rft.volume=2&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2006.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - scaffolds; polylactic acid; Tissue engineering; Esters; Stem cells; Chondrocytes; Biomaterials; Mesenchyme; Cell culture; Cell proliferation; Scanning electron microscopy; Extracellular matrix; Fibers; Lactic acid DO - http://dx.doi.org/10.1016/j.actbio.2006.02.005 ER - TY - JOUR T1 - Serum Concentrations of 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and Risk of Primary Liver Cancer AN - 19367881; 7129144 AB - BACKGROUND: 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) exposure has been demonstrated to cause liver tumors in laboratory rodents. DDT's persistent metabolite and environmental degradation product, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also been associated with liver tumors in laboratory animals. Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear. METHODS: We carried out a nested case-control study among the participants of the Nutritional Intervention Trials in Linxian, China. The case group included 168 individuals who developed liver cancer during the trials, and the control group included 385 individuals frequency-matched on age and sex who were alive and well at the end of the study. Serum concentrations of DDT and DDE were measured by gas chromatography-mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable analysis. RESULTS: In multivariable-adjusted models, the risk of developing liver cancer increased with increased serum DDT concentration (OR for quintile 1 versus quintile 5 = 3.8, 95% CI = 1.7 to 8.6, P sub(trend) = .0024). In contrast, there was no statistically significant association between liver cancer and serum DDE concentration. The association between high serum DDT concentration and liver cancer was stronger among individuals with DDE concentrations below the median value (odds ratio for tertile 3 versus tertile 1 = 3.55, 95% CI = 1.45 to 8.74) than those with concentrations above the median (OR = 1.70, 95% CI = 0.97 to 2.98). A calculation of crude liver cancer risk found that there would be 26 liver cancers per 100 000 persons per year in the lowest quintile of DDT exposure versus 46 liver cancers per 100 000 persons per year in the highest quintile of DDT exposure. CONCLUSIONS: DDT may be a risk factor for liver cancer, particularly among persons with lower DDE concentrations. Risk may be particularly increased among persons exposed directly to DDT (resulting in a higher ratio of DDT to DDE) or, alternatively, risk may be associated with individual ability to metabolize DDT to DDE. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Zhang, Mingdong AU - Sun, Xiu-Di AU - Fan, Jin-Hu AU - O'Brien, Thomas R AU - Wei, Wen-Qiang AU - Ortiz-Conde, Betty A AU - Dawsey, Sanford M AU - Weber, Jean-Philippe AU - Taylor, Philip R AU - Katki, Hormuzd AU - Mark, Steven D AU - Qiao, You-Lin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (KAM, CCA, MZ, TRO, SMD, PRT, HK, SDM) Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1005 EP - 1010 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts KW - Environmental degradation KW - Liver cancer KW - DDE KW - Laboratory animals KW - Statistical analysis KW - Metabolites KW - Tumors KW - Cancer KW - Mass spectroscopy KW - Spectrometry KW - Models KW - Insecticides KW - Nitrous oxide KW - Gas chromatography KW - Risk factors KW - DDT KW - Liver KW - China, People's Rep. KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Serum+Concentrations+of+1%2C1%2C1-Trichloro-2%2C2-bis%28p-chlorophenyl%29ethane+%28DDT%29+and+1%2C1-Dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+Risk+of+Primary+Liver+Cancer&rft.au=McGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BZhang%2C+Mingdong%3BSun%2C+Xiu-Di%3BFan%2C+Jin-Hu%3BO%27Brien%2C+Thomas+R%3BWei%2C+Wen-Qiang%3BOrtiz-Conde%2C+Betty+A%3BDawsey%2C+Sanford+M%3BWeber%2C+Jean-Philippe%3BTaylor%2C+Philip+R%3BKatki%2C+Hormuzd%3BMark%2C+Steven+D%3BQiao%2C+You-Lin&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2006-07-01&rft.volume=98&rft.issue=14&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Environmental degradation; Gas chromatography; Risk factors; Liver cancer; DDE; DDT; Statistical analysis; Laboratory animals; Metabolites; Tumors; Mass spectroscopy; Models; Insecticides; Nitrous oxide; Liver; Cancer; Spectrometry; China, People's Rep. ER - TY - JOUR T1 - Characterization of polar brevetoxin derivatives isolated from Karenia brevis cultures and natural blooms AN - 19290634; 6985236 AB - Several novel brevetoxin derivatives were isolated and identified in Karenia brevis cultures and natural blooms by using solid phase extraction (SPE) and LC/MS(MS) techniques. These analogs were more polar compared with previously described brevetoxins, and were poorly extractable by conventional non-polar solvent (chloroform) partitioning. Brevetoxin analogs were structurally confirmed as hydrolyzed (open A-ring) forms of brevetoxins PbTx-1, PbTx-7, PbTx-2, and PbTx-3, and of oxidized PbTx-1 and PbTx-2. Some of these open A-ring derivatives were in greater abundance than their non-hydrolyzed counterparts. All were in much greater abundance in bloom water filtrate compared with cell-rich fractions. Open A-ring compounds were cytotoxic in mouse neuroblastoma (N2a) cell assay. In the K. brevis bloom-exposed Eastern oyster, brevetoxin metabolites with opened A rings were identified (e.g., open- ring cysteine-PbTx conjugates), contributing to their overall toxin burden. JF - Toxicon AU - Abraham, Ann AU - Plakas, Steven M AU - Wang, Zhihong AU - Jester, Edward LE AU - El Said, Kathleen R AU - Granade, Hudson R AU - Henry, Michael S AU - Blum, Patricia C AU - Pierce, Richard H AU - Dickey, Robert W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA, ann.abraham@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 104 EP - 115 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 48 IS - 1 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Brevetoxins KW - Karenia brevis KW - Eastern oyster KW - LC/MS KW - Molecular structure KW - Marine KW - Algal blooms KW - Toxicants KW - Analogs KW - Solvents KW - Phytoplankton KW - Cell culture KW - Metabolites KW - Animal physiology KW - Toxicity KW - Toxins KW - Neuroblastoma KW - Chloroform KW - Cytotoxicity KW - K 03410:Animal Diseases KW - Q1 08461:Plankton KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19290634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Characterization+of+polar+brevetoxin+derivatives+isolated+from+Karenia+brevis+cultures+and+natural+blooms&rft.au=Abraham%2C+Ann%3BPlakas%2C+Steven+M%3BWang%2C+Zhihong%3BJester%2C+Edward+LE%3BEl+Said%2C+Kathleen+R%3BGranade%2C+Hudson+R%3BHenry%2C+Michael+S%3BBlum%2C+Patricia+C%3BPierce%2C+Richard+H%3BDickey%2C+Robert+W&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2006-07-01&rft.volume=48&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Molecular structure; Algal blooms; Toxicants; Analogs; Solvents; Phytoplankton; Animal physiology; Metabolites; Toxicity; Chloroform; Cytotoxicity; Brevetoxins; Cell culture; Neuroblastoma; Toxins; Karenia brevis; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2006.04.015 ER - TY - JOUR T1 - Functional Heterogeneity of RpoS in Stress Tolerance of Enterohemorrhagic Escherichia coli Strains AN - 17264482; 6992642 AB - The stationary-phase sigma factor (RpoS) regulates many cellular responses to environmental stress conditions such as heat, acid, and alkali shocks. On the other hand, mutations at the rpoS locus have frequently been detected among pathogenic as well as commensal strains of Escherichia coli. The objective of this study was to perform a functional analysis of the RpoS-mediated stress responses of enterohemorrhagic E. coli strains from food-borne outbreaks. E. coli strains belonging to serotypes O157:H7, O111:H11, and O26:H11 exhibited polymorphisms for two phenotypes widely used to monitor rpoS mutations, heat tolerance and glycogen synthesis, as well as for two others, alkali tolerance and adherence to Caco-2 cells. However, these strains synthesized the oxidative acid resistance system through an rpoS-dependent pathway. During the transition from mildly acidic growth conditions (pH 5.5) to alkaline stress (pH 10.2), cell survival was dependent on rpoS functionality. Some strains were able to overcome negative regulation by RpoS and induced higher {szligbeta}-galactosidase activity without compromising their acid resistance. There were no major differences in the DNA sequences in the rpoS coding regions among the tested strains. The heterogeneity of rpoS-dependent phenotypes observed for stress-related phenotypes was also evident in the Caco-2 cell adherence assay. Wild-type O157:H7 strains with native rpoS were less adherent than rpoS-complemented counterpart strains, suggesting that rpoS functionality is needed. These results show that some pathogenic E. coli strains can maintain their acid tolerance capability while compromising other RpoS-dependent stress responses. Such adaptation processes may have significant impact on a pathogen's survival in food processing environments, as well in the host's stomach and intestine. JF - Applied and Environmental Microbiology AU - Bhagwat, Arvind A AU - Tan, Jasmine AU - Sharma, Manan AU - Kothary, Mahendra AU - Low, Sharon AU - Tall, Ben D AU - Bhagwat, Medha AD - Produce Quality and Safety Laboratory. Food Technology and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, Maryland 20705-2350. Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland 20708. National Center for Biotechnology Information, Bldg. 38A, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 4978 EP - 4986 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 7 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Food processing KW - Serotypes KW - Adaptations KW - Growth conditions KW - Nucleotide sequence KW - Commensals KW - Heat tolerance KW - Glycogen KW - Shock KW - Heat KW - Escherichia coli KW - Intestine KW - Environmental stress KW - Sigma factor KW - Alkalis KW - Mutation KW - pH effects KW - Stomach KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Functional+Heterogeneity+of+RpoS+in+Stress+Tolerance+of+Enterohemorrhagic+Escherichia+coli+Strains&rft.au=Bhagwat%2C+Arvind+A%3BTan%2C+Jasmine%3BSharma%2C+Manan%3BKothary%2C+Mahendra%3BLow%2C+Sharon%3BTall%2C+Ben+D%3BBhagwat%2C+Medha&rft.aulast=Bhagwat&rft.aufirst=Arvind&rft.date=2006-07-01&rft.volume=72&rft.issue=7&rft.spage=4978&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Cell survival; Adaptations; Serotypes; Growth conditions; Nucleotide sequence; Heat tolerance; Commensals; Glycogen; Shock; Heat; Intestine; Environmental stress; Alkalis; Sigma factor; pH effects; Mutation; Stomach; Escherichia coli ER - TY - JOUR T1 - Retrospective Assessment of Radiation Exposure Using Biological Dosimetry: Chromosome Painting, Electron Paramagnetic Resonance and the Glycophorin A Mutation Assay AN - 17264168; 7002787 AB - Biological monitoring of dose can contribute important, independent estimates of cumulative radiation exposure in epidemiological studies, especially in studies in which the physical dosimetry is lacking. Three biodosimeters that have been used in epidemiological studies to estimate past radiation exposure from external sources will be highlighted: chromosome painting or FISH (fluorescence in situ hybridization), the glycophorin A somatic mutation assay (GPA), and electron paramagnetic resonance (EPR) with teeth. All three biodosimeters have been applied to A-bomb survivors, Chernobyl clean-up workers, and radiation workers. Each biodosimeter has unique advantages and limitations depending upon the level and type of radiation exposure. Chromosome painting has been the most widely applied biodosimeter in epidemiological studies of past radiation exposure, and results of these studies provide evidence that dose-related translocations persist for decades. EPR tooth dosimetry has been used to validate dose models of acute and chronic radiation exposure, although the present requirement of extracted teeth has been a disadvantage. GPA has been correlated with physically based radiation dose after high-dose, acute exposures but not after low-dose, chronic exposures. Interindividual variability appears to be a limitation for both chromosome painting and GPA. Both of these techniques can be used to estimate the level of past radiation exposure to a population, whereas EPR can provide individual dose estimates of past exposure. This paper will review each of these three biodosimeters and compare their application in selected epidemiological studies. JF - Radiation Research AU - Kleinerman, R A AU - Romanyukha, A A AU - Schauer, DA AU - Tucker, J D AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 287 EP - 302 PB - Radiation Research Society VL - 166 IS - 1 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; Toxicology Abstracts KW - E.S.R. KW - Teeth KW - alpha Radiation KW - Dosimetry KW - Models KW - Workers KW - Chromosomes KW - Chromosome translocations KW - Radiation KW - Chronic exposure KW - Reviews KW - Mutation KW - Translocation KW - Fluorescence in situ hybridization KW - X 24390:Radioactive Materials KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Retrospective+Assessment+of+Radiation+Exposure+Using+Biological+Dosimetry%3A+Chromosome+Painting%2C+Electron+Paramagnetic+Resonance+and+the+Glycophorin+A+Mutation+Assay&rft.au=Kleinerman%2C+R+A%3BRomanyukha%2C+A+A%3BSchauer%2C+DA%3BTucker%2C+J+D&rft.aulast=Kleinerman&rft.aufirst=R&rft.date=2006-07-01&rft.volume=166&rft.issue=1&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR3273.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=166&issue=1&page=287 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Teeth; E.S.R.; alpha Radiation; Dosimetry; Models; Workers; Chromosomes; Radiation; Chromosome translocations; Chronic exposure; Reviews; Translocation; Mutation; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1667/RR3273.1 ER - TY - JOUR T1 - National Estimates of Hospital Use by Children With HIV Infection in the United States: Analysis of Data From the 2000 KIDS Inpatient Database AN - 17254807; 6998593 AB - OBJECTIVES. The purpose of this research was to describe hospital use patterns of HIV-infected children in the United States. STUDY DESIGN. We analyzed a nationwide, stratified probability sample of 2.5 million hospital discharges of children and adolescents during the year 2000, weighted to 7.3 million discharges nationally. We excluded discharges after hospitalizations related to pregnancy/childbirth and their complications and discharges of neonates 18 years of age. Diagnoses were identified through the use of the Clinical Classification Software with grouping of related diagnoses. RESULTS. We estimated that there were 4107 hospitalizations of HIV-infected children in 2000 and that these hospitalizations accounted for similar to $100 million in hospital charges and >30000 hospital days. Infections, including sepsis and pneumonia, were among the most frequent diagnoses in such hospitalizations, followed by diagnoses related to gastrointestinal conditions, nutritional deficiencies and anemia, fluid/electrolyte disorders, central nervous system disorders, cardiovascular disorders, and respiratory illnesses. Compared with hospitalizations of non-HIV-infected children, hospitalizations of HIV-infected ones were more likely to be in urban areas, in pediatric/teaching hospitals, and in the Northeast, and the expected payer was more likely to be Medicaid (77.6% vs 37.2%). Compared with children without HIV, those with HIV tended to be older (median age: 9.5 years vs 5.2 years), to have been hospitalized longer (mean: 7.8 days vs 3.9 days), and to have incurred higher hospital costs (mean: $23221 vs $11215); HIV-associated hospitalizations ended in the patient's death more frequently than non-HIV ones (1.8% vs 0.4%), and complications of medical care were also more common (10.8% vs 6.2%). CONCLUSIONS. Infections account for the majority of hospitalizations of HIV-infected children in the United States, although nutritional deficiencies, anemia and other hematologic disorders, gastrointestinal and renal disorders, and complications of medical care are also more common among hospitalized children with HIV than among those without HIV. JF - Pediatrics AU - Kourtis, Athena P AU - Paramsothy, Pangaja AU - Posner, Samuel F AU - Meikle, Susan F AU - Jamieson, Denise J AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Eastern Virginia Medical School, Norfolk, Virginia. CONRAD Program, Arlington, Virginia. Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - e167 EP - e173 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 118 IS - 1 SN - 0031-4005, 0031-4005 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Central nervous system KW - Age KW - Data processing KW - Pediatrics KW - Adolescence KW - Anemia KW - Children KW - Infection KW - Pregnancy KW - Computer programs KW - Databases KW - Nutrient deficiency KW - Sepsis KW - software KW - Classification KW - Human immunodeficiency virus KW - Kidney KW - Geriatrics KW - Neonates KW - Pneumonia KW - Hospitals KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17254807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=National+Estimates+of+Hospital+Use+by+Children+With+HIV+Infection+in+the+United+States%3A+Analysis+of+Data+From+the+2000+KIDS+Inpatient+Database&rft.au=Kourtis%2C+Athena+P%3BParamsothy%2C+Pangaja%3BPosner%2C+Samuel+F%3BMeikle%2C+Susan+F%3BJamieson%2C+Denise+J&rft.aulast=Kourtis&rft.aufirst=Athena&rft.date=2006-07-01&rft.volume=118&rft.issue=1&rft.spage=e167&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Central nervous system; Age; Data processing; Pediatrics; Adolescence; Anemia; Infection; Children; Pregnancy; Databases; Computer programs; software; Sepsis; Nutrient deficiency; Classification; Geriatrics; Kidney; Neonates; Pneumonia; Hospitals; Human immunodeficiency virus ER - TY - JOUR T1 - "Islands of Risk": Subgroups of Adolescents at Risk for HIV AN - 17254349; 6997643 AB - OBJECTIVE: To use cluster analysis to determine profiles of adolescents at risk for HIV. METHODS: Adolescents 15-21 years old (N = 1153) with a history of unprotected sex were assessed in five domains of risk (unprotected sex, alcohol/marijuana use, other drug use, mental health crises, and arrest/school dropout) as well as demographic, contextual, and behavioral variables. RESULTS: Cluster analysis revealed separate three-cluster solutions for males and females. Among males, clusters were characterized by (a) mental health crises and unprotected sex, (b) alcohol/marijuana use and unprotected sex, and (c) lower risk. Among females, clusters were distinguished by (a) unprotected sex, (b) substance use and mental health crises, and (c) lower risk. Cluster membership was associated with secondary variables related to sexual risk. CONCLUSIONS: Even within populations of high-risk adolescents, subgroups exist for which specific risk factors co-occur, particularly unprotected sex, mental health crises, and substance use. These patterns suggest that effective HIV prevention interventions may need to target the association between mental health and/or substance abuse with sexual risk for some adolescents. JF - Journal of Pediatric Psychology AU - Houck, Christopher D AU - Lescano, Celia M AU - Brown, Larry K AU - Tolou-Shams, Marina AU - Thompson, Jonathon AU - DiClemente, Ralph AU - Fernandez, MIsabel AU - Pugatch, David AU - Schlenger, William E AU - Silver, Barbara J AD - Rhode Island Hospital and Brown Medical School, Emory University, University of Miami, Research Triangle Institute, and Substance Abuse and Mental Health Services Administration Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 619 EP - 629 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 31 IS - 6 SN - 0146-8693, 0146-8693 KW - Risk Abstracts KW - substance abuse KW - Alcohol KW - Historical account KW - Mental disorders KW - Human immunodeficiency virus KW - Psychology KW - prevention KW - Drug abuse KW - Sexual behavior KW - Adolescents KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17254349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=%22Islands+of+Risk%22%3A+Subgroups+of+Adolescents+at+Risk+for+HIV&rft.au=Houck%2C+Christopher+D%3BLescano%2C+Celia+M%3BBrown%2C+Larry+K%3BTolou-Shams%2C+Marina%3BThompson%2C+Jonathon%3BDiClemente%2C+Ralph%3BFernandez%2C+MIsabel%3BPugatch%2C+David%3BSchlenger%2C+William+E%3BSilver%2C+Barbara+J&rft.aulast=Houck&rft.aufirst=Christopher&rft.date=2006-07-01&rft.volume=31&rft.issue=6&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - substance abuse; Historical account; Alcohol; Mental disorders; Psychology; prevention; Drug abuse; Sexual behavior; Adolescents; Human immunodeficiency virus ER - TY - JOUR T1 - Real-time, quantitative PCR assays for the detection of virus-specific DNA in samples with mixed populations of polyomaviruses AN - 17209532; 6909640 AB - Mixtures of polyomaviruses can be present in the central nervous system, the gastrointestinal tract, the genitourinary tract, blood, and urban sewage. We have developed 12 primer/probe sets (four per virus) for real-time, quantitative PCR assays (TaqMan) that can specifically detect BKV, JCV, and SV40 genomes present in mixtures of these viruses. The specificities of these primer/probe sets were determined by evaluating their level of interaction with the DNA from other polyomaviruses and their ability to estimate the number of copies of homologous viral DNA in blinded samples of defined mixtures of three polyomaviral DNAs. Three early region and three late region primer/probe sets determined, within a two-fold range, the number of copies of their respective DNAs. Four sets of SV40 primer/probes also detected 1.1-2.4 copies of SV40 DNA per COS-1 cell, cells estimated to contain a single copy of SV40 DNA. Three JCV primer/probe sets detected 3.7-4.2 copies per cell of JCV DNA in the JCV-transformed cell line M1-HR, cells estimated to contain between 0.5 and 1 copy of the JCV genome. We suggest that the virus-specific primer/probe sets in this study be considered sufficiently characterized to initiate the quantification of polyomavirus DNA in biological samples. JF - Journal of Virological Methods AU - Pal, A AU - Sirota, L AU - Maudru, T AU - Peden, K AU - Lewis, A M AD - Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States, lewisa@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 32 EP - 42 VL - 135 IS - 1 SN - 0166-0934, 0166-0934 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Genomes KW - Central nervous system KW - DNA probes KW - Polyomavirus KW - Genitourinary tract KW - Late region KW - JC virus KW - Blood KW - Digestive tract KW - Sewage KW - Early region KW - Simian virus 40 KW - Polymerase chain reaction KW - Primers KW - Gastrointestinal tract KW - A 01114:Viruses KW - N 14810:Methods KW - V 22121:Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17209532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Real-time%2C+quantitative+PCR+assays+for+the+detection+of+virus-specific+DNA+in+samples+with+mixed+populations+of+polyomaviruses&rft.au=Pal%2C+A%3BSirota%2C+L%3BMaudru%2C+T%3BPeden%2C+K%3BLewis%2C+A+M&rft.aulast=Pal&rft.aufirst=A&rft.date=2006-07-01&rft.volume=135&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2006.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Blood; Central nervous system; Digestive tract; Sewage; Early region; DNA probes; Polymerase chain reaction; Genitourinary tract; Primers; Gastrointestinal tract; Late region; Simian virus 40; Polyomavirus; JC virus DO - http://dx.doi.org/10.1016/j.jviromet.2006.01.018 ER - TY - JOUR T1 - Ignition of hydraulic fluid sprays by open flames and hot surfaces AN - 17082746; 6708350 AB - A study of the ignition of non-fire-resistant hydraulic fluid sprays was conducted by the National Institute for Occupational Safety and Health. Both an open flame and a hot steel surface were used as the external heat sources. With the open flame as the heat source, the minimum oil temperature and minimum spray nozzle pressure that resulted in an ignition were measured. The effects of the distance between the open flame and the nozzle and the nozzle orifice diameter on the ignitability of the hydraulic fluid sprays were examined. With the hot surface as the heat source, the minimum surface ignition temperature was determined. The degree of oil atomization and the relative direction of oil injection with respect to the hot surface are discussed. The ignition of oil sprays from the impingement of oil jets onto a vertical surface was also investigated. Finally, the results are compared with those obtained for fire-resistant hydraulic fluids. JF - Journal of Loss Prevention in the Process Industries AU - Yuan, L AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 353 EP - 361 VL - 19 IS - 4 KW - Health & Safety Science Abstracts KW - Oil KW - Hydraulics KW - Fires KW - Sprays KW - Occupational safety KW - Temperature KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17082746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Loss+Prevention+in+the+Process+Industries&rft.atitle=Ignition+of+hydraulic+fluid+sprays+by+open+flames+and+hot+surfaces&rft.au=Yuan%2C+L&rft.aulast=Yuan&rft.aufirst=L&rft.date=2006-07-01&rft.volume=19&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Loss+Prevention+in+the+Process+Industries&rft.issn=&rft_id=info:doi/10.1016%2Fj.jlp.2005.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Oil; Fires; Hydraulics; Occupational safety; Sprays; Temperature DO - http://dx.doi.org/10.1016/j.jlp.2005.09.001 ER - TY - JOUR T1 - Quantitative and confirmatory analyses of malachite green and leucomalachite green residues in fish and shrimp. AN - 68099667; 16786992 AB - Liquid chromatographic methods are presented for the quantitative and confirmatory determination of malachite green (MG) and leucomalachite green (LMG) for channel catfish, rainbow trout, tilapia, basa, Atlantic salmon, and tiger shrimp. Residues were extracted from tissues with ammonium acetate buffer and acetonitrile and isolated by partitioning into dichloromethane. LMG was quantitatively oxidized to the chromic MG with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Extracts were analyzed for total MG by liquid chromatography with both visible detection (LC-VIS) at 618 nm for routine screening and ion trap mass spectrometry (LC-MSn) with no discharge-atmospheric pressure chemical ionization for residue confirmation. The method was validated in each species fortified with LMG at 1, 2, 4, and 10 ng/g (ppb), and average recoveries ranged from 85.9 to 93.9%. Quantitative data were consistent for the two detection methods, with measured method detection limits of 1.0 ng/g for LC-VIS and 0.25 ng/g for LC-MSn. Incurred tissues from catfish, trout, tilapia, and salmon that had been treated with MG were also extracted and analyzed as part of this study. JF - Journal of agricultural and food chemistry AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Roybal, José E AD - Animal Drugs Research Center, Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087, USA. Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 SP - 4517 EP - 4523 VL - 54 IS - 13 SN - 0021-8561, 0021-8561 KW - Aniline Compounds KW - 0 KW - Rosaniline Dyes KW - malachite green KW - 12058M7ORO KW - leucomalachite green KW - 8U61G37Z20 KW - Index Medicus KW - Animals KW - Chromatography, Liquid -- methods KW - Ictaluridae KW - Oncorhynchus mykiss KW - Tilapia KW - Aquaculture KW - Salmo salar KW - Penaeidae KW - Fishes KW - Food Contamination -- analysis KW - Aniline Compounds -- analysis KW - Rosaniline Dyes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68099667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Quantitative+and+confirmatory+analyses+of+malachite+green+and+leucomalachite+green+residues+in+fish+and+shrimp.&rft.au=Andersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BRoybal%2C+Jos%C3%A9+E&rft.aulast=Andersen&rft.aufirst=Wendy&rft.date=2006-06-28&rft.volume=54&rft.issue=13&rft.spage=4517&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - US FDA Regulation of Computerized and Robotic Surgical Systems T2 - 10th Annual Conference of the International Society for Computer Aided Surgery (ISCAS) AN - 40122576; 4260572 JF - 10th Annual Conference of the International Society for Computer Aided Surgery (ISCAS) AU - Yen, D AU - Roxolana, H AU - Neil, O Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - FDA KW - Robotics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40122576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Conference+of+the+International+Society+for+Computer+Aided+Surgery+%28ISCAS%29&rft.atitle=US+FDA+Regulation+of+Computerized+and+Robotic+Surgical+Systems&rft.au=Yen%2C+D%3BRoxolana%2C+H%3BNeil%2C+O&rft.aulast=Yen&rft.aufirst=D&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Conference+of+the+International+Society+for+Computer+Aided+Surgery+%28ISCAS%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cars-int.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current Status of TB Vaccine Development T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40211491; 4334890 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Brennan, Michael J Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40211491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Current+Status+of+TB+Vaccine+Development&rft.au=Brennan%2C+Michael+J&rft.aulast=Brennan&rft.aufirst=Michael&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patient Reported Outcome Measures in Clinical Trials of Infectious Diseases: How they can Help us T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208749; 4334886 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Burke, Laurie B Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Patient+Reported+Outcome+Measures+in+Clinical+Trials+of+Infectious+Diseases%3A+How+they+can+Help+us&rft.au=Burke%2C+Laurie+B&rft.aulast=Burke&rft.aufirst=Laurie&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiological Cut-Off Values for Four Antimicrobial Agents against Aeromonas salmonicida Isolates using MIC and Zone Diameter Frequency Distributions T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208360; 4334914 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Miller, R A AU - Walker, R D AU - Reimschuessel, R Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Fish diseases KW - Bacterial diseases KW - Aeromonas salmonicida UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Epidemiological+Cut-Off+Values+for+Four+Antimicrobial+Agents+against+Aeromonas+salmonicida+Isolates+using+MIC+and+Zone+Diameter+Frequency+Distributions&rft.au=Miller%2C+R+A%3BWalker%2C+R+D%3BReimschuessel%2C+R&rft.aulast=Miller&rft.aufirst=R&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pandemic Flu Preparedness and Emerging Resistance in Flu Strains T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208326; 4334891 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Robinson, Robin Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Pandemics KW - Strains UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Pandemic+Flu+Preparedness+and+Emerging+Resistance+in+Flu+Strains&rft.au=Robinson%2C+Robin&rft.aulast=Robinson&rft.aufirst=Robin&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptive Designs in Clinical Trials of Infectious Diseases: What it is and What it isnt T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208191; 4334887 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Lin, Daphne T.Y. 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T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40207648; 4334888 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Powers, John H Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40207648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Increasing+the+Efficiency+of+Clinical+Trials+in+Infectious+Diseases%3A+Where+do+we+go+from+here%3F&rft.au=Powers%2C+John+H&rft.aulast=Powers&rft.aufirst=John&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Misclassification Bias and Measurement Error in Clinical Trials for Infectious Diseases: How they Affect the Efficiency of Trials T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40202958; 4334885 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Cooper, Charles K Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40202958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Misclassification+Bias+and+Measurement+Error+in+Clinical+Trials+for+Infectious+Diseases%3A+How+they+Affect+the+Efficiency+of+Trials&rft.au=Cooper%2C+Charles+K&rft.aulast=Cooper&rft.aufirst=Charles&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aminoglycoside Resistance Genes Found in Enterococcus spp. Recovered from Retail Meats T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40199545; 4334901 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Bodeis-Jones, S M AU - White, D G Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Meat KW - Enterococcus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40199545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Aminoglycoside+Resistance+Genes+Found+in+Enterococcus+spp.+Recovered+from+Retail+Meats&rft.au=Bodeis-Jones%2C+S+M%3BWhite%2C+D+G&rft.aulast=Bodeis-Jones&rft.aufirst=S&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Local Perspective: The Sanitarian's Role During Disaster Relief Efforts T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40178122; 4323295 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bhatt, Chirag H Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Disasters KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40178122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Local+Perspective%3A+The+Sanitarian%27s+Role+During+Disaster+Relief+Efforts&rft.au=Bhatt%2C+Chirag+H&rft.aulast=Bhatt&rft.aufirst=Chirag&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What is Reduced-Oxygen Packaging and What are the Food Safety Concerns and Controls? T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40177759; 4323177 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bohm, Shirley B Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Packaging KW - Food KW - Public health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40177759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=What+is+Reduced-Oxygen+Packaging+and+What+are+the+Food+Safety+Concerns+and+Controls%3F&rft.au=Bohm%2C+Shirley+B&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Federal Perspective: CDC Response to Environmental Health Concerns from Hurricane Katrina in New Orleans T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40176507; 4323297 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Manwaring, Jan C AU - Herring, Michael E Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - USA, Louisiana, New Orleans KW - Hurricanes KW - Environmental health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40176507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Federal+Perspective%3A+CDC+Response+to+Environmental+Health+Concerns+from+Hurricane+Katrina+in+New+Orleans&rft.au=Manwaring%2C+Jan+C%3BHerring%2C+Michael+E&rft.aulast=Manwaring&rft.aufirst=Jan&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perception as RealityStrengths, Successes, and Solutions to Community-Based Sheltering T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40176185; 4323196 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bhatt, Chirag H AU - Bock, Courtney AU - Frank, Cory AU - Lane, Janet AU - Maloney, Joe AU - Miller, Mark D Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Perception KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40176185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Perception+as+RealityStrengths%2C+Successes%2C+and+Solutions+to+Community-Based+Sheltering&rft.au=Bhatt%2C+Chirag+H%3BBock%2C+Courtney%3BFrank%2C+Cory%3BLane%2C+Janet%3BMaloney%2C+Joe%3BMiller%2C+Mark+D&rft.aulast=Bhatt&rft.aufirst=Chirag&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Controlling Foodborne Viruses: Moving into the Next Millenium of Food Safety T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40175161; 4323302 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Fanaselle, Wendy Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Viruses KW - Food KW - Public health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40175161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Controlling+Foodborne+Viruses%3A+Moving+into+the+Next+Millenium+of+Food+Safety&rft.au=Fanaselle%2C+Wendy&rft.aulast=Fanaselle&rft.aufirst=Wendy&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethnic Foods: Meeting the Challenge T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40173036; 4323265 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Chamberlin, Clint R Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Food KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40173036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Ethnic+Foods%3A+Meeting+the+Challenge&rft.au=Chamberlin%2C+Clint+R&rft.aulast=Chamberlin&rft.aufirst=Clint&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple SalmonellaOutbreaks Associated with Tomatoes, 2004 T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40168780; 4323306 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Hill, Thomas A Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Environmental health KW - Education KW - Lycopersicon esculentum KW - Salmonidae KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40168780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Multiple+SalmonellaOutbreaks+Associated+with+Tomatoes%2C+2004&rft.au=Hill%2C+Thomas+A&rft.aulast=Hill&rft.aufirst=Thomas&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Seal Quality and Imperfections in Flexible Pouches by Infrared Imaging Thermography T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144718; 4293744 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Song, Y AU - Setikaite, I AU - Hancock, E AU - Sadler, G Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Thermography KW - Marine mammals KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Evaluation+of+Seal+Quality+and+Imperfections+in+Flexible+Pouches+by+Infrared+Imaging+Thermography&rft.au=Song%2C+Y%3BSetikaite%2C+I%3BHancock%2C+E%3BSadler%2C+G&rft.aulast=Song&rft.aufirst=Y&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Medium and Incubation Conditions on Recovery of High Pressure-Injured Clostridium Botulinum Spores T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144412; 4293629 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Reddy, N AU - Tetzloff, R Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Spores KW - Clostridium botulinum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Effect+of+Medium+and+Incubation+Conditions+on+Recovery+of+High+Pressure-Injured+Clostridium+Botulinum+Spores&rft.au=Reddy%2C+N%3BTetzloff%2C+R&rft.aulast=Reddy&rft.aufirst=N&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of CO@@d2@ and O@@d2@ on High Pressure Inactivation of Listeria Innocua T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144298; 4293626 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Murakami, E AU - Larkin, J AU - Ravishankar, S AU - Chen, L AU - Patazca, E AU - Chirtel, S Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Carbon dioxide KW - Pressure KW - Listeria innocua UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=The+Effect+of+CO%40%40d2%40+and+O%40%40d2%40+on+High+Pressure+Inactivation+of+Listeria+Innocua&rft.au=Murakami%2C+E%3BLarkin%2C+J%3BRavishankar%2C+S%3BChen%2C+L%3BPatazca%2C+E%3BChirtel%2C+S&rft.aulast=Murakami&rft.aufirst=E&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thermal Stability of Ricin in Infant Formula T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40124284; 4293223 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Jackson, L AU - Tolleson, W AU - Palucki, D Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Infant formulas KW - Ricin KW - Thermal stability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Thermal+Stability+of+Ricin+in+Infant+Formula&rft.au=Jackson%2C+L%3BTolleson%2C+W%3BPalucki%2C+D&rft.aulast=Jackson&rft.aufirst=L&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Intake Estimate of Folic Acid in the U.S. Population T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40078268; 4293381 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Lee, H Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - USA KW - Dietary intake KW - Folic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Dietary+Intake+Estimate+of+Folic+Acid+in+the+U.S.+Population&rft.au=Lee%2C+H&rft.aulast=Lee&rft.aufirst=H&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multilocus Sequence Analysis of Housekeeping Genes of the Mycoplasma and Acholeplasma Genera: Phylogeny and Species Identification T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40116995; 4258744 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Volokhov, D V AU - George, J AU - Neverov, A A AU - Ikonomi, P AU - Anderson, C M AU - Chizhikov, V E Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Phylogeny KW - Nucleotide sequence KW - Acholeplasma KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Multilocus+Sequence+Analysis+of+Housekeeping+Genes+of+the+Mycoplasma+and+Acholeplasma+Genera%3A+Phylogeny+and+Species+Identification&rft.au=Volokhov%2C+D+V%3BGeorge%2C+J%3BNeverov%2C+A+A%3BIkonomi%2C+P%3BAnderson%2C+C+M%3BChizhikov%2C+V+E&rft.aulast=Volokhov&rft.aufirst=D&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Response after Hurricane Katrina by the Houston and Harris County Departments of Health T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 39999813; 4257924 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Arafat, R AU - Palacio, H AU - Shah, U Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - USA, Texas, Houston KW - Public health KW - Hurricanes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39999813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Public+Health+Response+after+Hurricane+Katrina+by+the+Houston+and+Harris+County+Departments+of+Health&rft.au=Arafat%2C+R%3BPalacio%2C+H%3BShah%2C+U&rft.aulast=Arafat&rft.aufirst=R&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Medical devices; exception from general requirements for informed consent. Interim final rule. AN - 68575102; 16795934 AB - The Food and Drug Administration (FDA) is issuing this interim final rule to amend its regulations to establish a new exception from the general requirements for informed consent, to permit the use of investigational in vitro diagnostic devices to identify chemical, biological, radiological, or nuclear agents without informed consent in certain circumstances. The agency is taking this action because it is concerned that, during a potential terrorism event or other potential public health emergency, delaying the testing of specimens to obtain informed consent may threaten the life of the subject. In many instances, there may also be others who have been exposed to, or who may be at risk of exposure to, a dangerous chemical, biological, radiological, or nuclear agent, thus necessitating identification of the agent as soon as possible. FDA is creating this exception to help ensure that individuals who may have been exposed to a chemical, biological, radiological, or nuclear agent are able to benefit from the timely use of the most appropriate diagnostic devices, including those that are investigational. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2006/06/07/ PY - 2006 DA - 2006 Jun 07 SP - 32827 EP - 32834 VL - 71 IS - 109 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Public Health -- legislation & jurisprudence KW - Humans KW - In Vitro Techniques KW - Therapies, Investigational KW - Device Approval -- legislation & jurisprudence KW - Terrorism -- legislation & jurisprudence KW - Disaster Planning -- legislation & jurisprudence KW - Informed Consent -- legislation & jurisprudence KW - Diagnostic Equipment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68575102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Medical+devices%3B+exception+from+general+requirements+for+informed+consent.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2006-06-07&rft.volume=71&rft.issue=109&rft.spage=32827&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Birth weight and breast cancer risk AN - 899129478; 13759221 AB - Exploring whether the positive association between birth weight and breast cancer risk differs by other breast cancer risk factors may help inform speculation about biological mechanism. In these data, high birth weight was associated with breast cancer risk in younger and in more educated women, but was not associated overall.British Journal of Cancer (2006) 94, 1734-1737. doi:10.1038/sj.bjc.6603122 www.bjcancer.com Published online 25 April 2006 JF - British Journal of Cancer AU - Troisi, R AU - Hatch, E E AU - Titus-Ernstoff, L AU - Palmer, J R AU - Hyer, M AU - Strohsnitter, W C AU - Robboy, S J AU - Kaufman, R AU - Herbst, A AU - Adam, E AU - Hoover, R N AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA Y1 - 2006/06/05/ PY - 2006 DA - 2006 Jun 05 SP - 1734 EP - 1737 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 94 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Breast cancer KW - birth weight KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Birth+weight+and+breast+cancer+risk&rft.au=Troisi%2C+R%3BHatch%2C+E+E%3BTitus-Ernstoff%2C+L%3BPalmer%2C+J+R%3BHyer%2C+M%3BStrohsnitter%2C+W+C%3BRobboy%2C+S+J%3BKaufman%2C+R%3BHerbst%2C+A%3BAdam%2C+E%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2006-06-05&rft.volume=94&rft.issue=11&rft.spage=1734&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - birth weight; Breast cancer; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6603122 ER - TY - JOUR T1 - UvrB Domain 4, an Autoinhibitory Gate for Regulation of DNA Binding and ATPase Activity AN - 17231352; 6947544 AB - UvrB, a central DNA damage recognition protein in bacterial nucleotide excision repair, has weak affinity for DNA, and its ATPase activity is activated by UvrA and damaged DNA. Regulation of DNA binding and ATP hydrolysis by UvrB is poorly understood. Using atomic force microscopy and biochemical assays, we found that truncation of domain 4 of Bacillus caldotenax UvrB (UvrB Delta 4) leads to multiple changes in protein function. Protein dimerization decreases with an similar to 8-fold increase of the equilibrium dissociation constant and an increase in DNA binding. Loss of domain 4 causes the DNA binding mode of UvrB to change from dimer to monomer, and affinity increases with the apparent dissociation constants on nondamaged and damaged single-stranded DNA decreasing 22- and 14-fold, respectively. ATPase activity by UvrB Delta 4 increases 14- and 9-fold with and without single-stranded DNA, respectively, and UvrB Delta 4 supports UvrA-independent damage-specific incision by Cho on a bubble DNA substrate. We propose that other than its previously discovered role in regulating protein-protein interactions, domain 4 is an autoinhibitory domain regulating the DNA binding and ATPase activities of UvrB. JF - Journal of Biological Chemistry AU - Wang, Hong AU - DellaVecchia, Matthew J AU - Skorvaga, Milan AU - Croteau, Deborah L AU - Erie, Dorothy A AU - Van Houten, Bennett AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovakia, and the Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 Y1 - 2006/06/02/ PY - 2006 DA - 2006 Jun 02 SP - 15227 EP - 15237 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Monomers KW - DNA damage KW - Adenosinetriphosphatase KW - Nucleotide excision repair KW - atomic force microscopy KW - ATP KW - Single-stranded DNA KW - Bacillus KW - Hydrolysis KW - Protein interaction KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17231352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=UvrB+Domain+4%2C+an+Autoinhibitory+Gate+for+Regulation+of+DNA+Binding+and+ATPase+Activity&rft.au=Wang%2C+Hong%3BDellaVecchia%2C+Matthew+J%3BSkorvaga%2C+Milan%3BCroteau%2C+Deborah+L%3BErie%2C+Dorothy+A%3BVan+Houten%2C+Bennett&rft.aulast=Wang&rft.aufirst=Hong&rft.date=2006-06-02&rft.volume=281&rft.issue=22&rft.spage=15227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; DNA damage; Adenosinetriphosphatase; Nucleotide excision repair; atomic force microscopy; ATP; Single-stranded DNA; Hydrolysis; Protein interaction; Bacillus ER - TY - JOUR T1 - Use of nontraditional animals for evaluation of pharmaceutical products. AN - 68670076; 16863438 AB - Although the International Conference on Harmonization Guideline ICH M3 indicates the use of nonrodents for some studies of pharmaceutical products, the specific nonrodent species is not specified. Dogs are used most frequently; however, there may be reasons why dogs are not the best model for a particular drug. Minipigs are being used increasingly for evaluation of toxicity, especially for dermally applied drugs, and for various efficacy models. Hamsters may be used for the evaluation of intraoral drugs and for carcinogenicity studies. Less commonly, pharmaceutical manufacturers may choose on their own to use marmosets, when a nonhuman primate is considered critical to evaluation, or to use ferrets for specific purposes. When nontraditional species are used, there may be less historical information available and unique issues of their care, and differences in physiology and anatomy and susceptibility to infection need to be understood. Nonmammalian test species, such as zebrafish and Caenorhabditis elegans may be used by drug sponsors in screening assays, but are not yet ready for use in pivotal toxicology studies because of the difficulty in extrapolating to mammalian species. Use of nontraditional animal species may be proposed by a drug sponsor to a reviewing division with supporting data and reasons for using a particular species. JF - Expert opinion on drug metabolism & toxicology AU - Jacobs, Abigail AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. abigail.jacobs@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 345 EP - 349 VL - 2 IS - 3 SN - 1742-5255, 1742-5255 KW - Index Medicus KW - Swine KW - Animals KW - Ferrets KW - Caenorhabditis elegans KW - Callithrix KW - Species Specificity KW - Zebrafish KW - Cricetinae KW - Models, Animal KW - Toxicity Tests -- methods KW - Drug Evaluation, Preclinical -- methods KW - Swine, Miniature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68670076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Use+of+nontraditional+animals+for+evaluation+of+pharmaceutical+products.&rft.au=Jacobs%2C+Abigail&rft.aulast=Jacobs&rft.aufirst=Abigail&rft.date=2006-06-01&rft.volume=2&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-08 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photoirradiation of retinyl palmitate in ethanol with ultraviolet light--formation of photodecomposition products, reactive oxygen species, and lipid peroxides. AN - 68616261; 16823091 AB - We have previously reported that photoirradiation of retinyl palmitate (RP), a storage and ester form of vitamin A (retinol), with UVA light resulted in the formation of photodecomposition products, generation of reactive oxygen species, and induction of lipid peroxidation. In this paper, we report our results following the photoirradiation of RP in ethanol by an UV lamp with approximately equal UVA and UVB light. The photodecomposition products were separated by reversed-phase HPLC and characterized spectroscopically by comparison with authentic standards. The identified products include: 4-keto-RP, 11-ethoxy-12-hydroxy-RP, 13-ethoxy-14-hydroxy-RP, anhydroretinol (AR), and trans- and cis-15-ethoxy-AR. Photoirradiation of RP in the presence of a lipid, methyl linoleate, resulted in induction of lipid peroxidation. Lipid peroxidation was inhibited when sodium azide was present during photoirradiation which suggests free radicals were formed. Our results demonstrate that, similar to irradiation with UVA light, RP can act as a photosensitizer leading to free radical formation and induction of lipid peroxidation following irradiation with UVB light. JF - International journal of environmental research and public health AU - Xia, Qingsu AU - Yin, Jun J AU - Wamer, Wayne G AU - Cherng, Shu-Hui AU - Boudreau, Mary D AU - Howard, Paul C AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 185 EP - 190 VL - 3 IS - 2 SN - 1661-7827, 1661-7827 KW - Linoleic Acids KW - 0 KW - Reactive Oxygen Species KW - Vitamin A KW - 11103-57-4 KW - retinol palmitate KW - 1D1K0N0VVC KW - methyl linoleate KW - 24N6726DE5 KW - Ethanol KW - 3K9958V90M KW - Sodium Azide KW - 968JJ8C9DV KW - Deuterium Oxide KW - J65BV539M3 KW - Index Medicus KW - Ethanol -- radiation effects KW - Sodium Azide -- chemistry KW - Reactive Oxygen Species -- chemistry KW - Ethanol -- chemistry KW - Deuterium Oxide -- chemistry KW - Lipid Peroxidation KW - Linoleic Acids -- radiation effects KW - Ultraviolet Rays KW - Vitamin A -- analogs & derivatives KW - Vitamin A -- chemistry KW - Vitamin A -- radiation effects KW - Linoleic Acids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68616261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Photoirradiation+of+retinyl+palmitate+in+ethanol+with+ultraviolet+light--formation+of+photodecomposition+products%2C+reactive+oxygen+species%2C+and+lipid+peroxides.&rft.au=Xia%2C+Qingsu%3BYin%2C+Jun+J%3BWamer%2C+Wayne+G%3BCherng%2C+Shu-Hui%3BBoudreau%2C+Mary+D%3BHoward%2C+Paul+C%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2006-06-01&rft.volume=3&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=16617827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-07 N1 - Date created - 2006-07-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477] Toxicol Lett. 2006 May 5;163(1):30-43 [16384671] Eye (Lond). 2001 Jun;15(Pt 3):371-5 [11450760] J Invest Dermatol. 2003 Nov;121(5):1163-7 [14708621] Curr Med Chem. 2004 May;11(9):1163-82 [15134513] Crit Rev Food Sci Nutr. 1992;31(1-2):103-63 [1734916] Cancer Res. 1994 Apr 1;54(7 Suppl):1890s-1894s [8137306] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7491-5 [8052609] Biochem Biophys Res Commun. 1995 Nov 22;216(3):1110-7 [7488187] J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511] Chem Res Toxicol. 1997 May;10(5):485-94 [9168245] Free Radic Biol Med. 1999 Jan;26(1-2):202-26 [9890655] Mutat Res. 1999 Jul 16;428(1-2):5-10 [10517972] J Nutr Sci Vitaminol (Tokyo). 1999 Jun;45(3):353-8 [10524354] Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116] Mutagenesis. 2005 Mar;20(2):81-92 [15784692] Toxicol Ind Health. 2005 Sep;21(7-8):167-75 [16149731] Toxicol Sci. 2005 Nov;88(1):142-9 [16107546] Exp Gerontol. 2001 Apr;36(4-6):619-40 [11295504] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Decision threshold adjustment in class prediction. AN - 68600916; 16815772 AB - Standard classification algorithms are generally designed to maximize the number of correct predictions (concordance). The criterion of maximizing the concordance may not be appropriate in certain applications. In practice, some applications may emphasize high sensitivity (e.g., clinical diagnostic tests) and others may emphasize high specificity (e.g., epidemiology screening studies). This paper considers effects of the decision threshold on sensitivity, specificity, and concordance for four classification methods: logistic regression, classification tree, Fisher's linear discriminant analysis, and a weighted k-nearest neighbor. We investigated the use of decision threshold adjustment to improve performance of either sensitivity or specificity of a classifier under specific conditions. We conducted a Monte Carlo simulation showing that as the decision threshold increases, the sensitivity decreases and the specificity increases; but, the concordance values in an interval around the maximum concordance are similar. For specified sensitivity and specificity levels, an optimal decision threshold might be determined in an interval around the maximum concordance that meets the specified requirement. Three example data sets were analyzed for illustrations. JF - SAR and QSAR in environmental research AU - Chen, J J AU - Tsai, C-A AU - Moon, H AU - Ahn, H AU - Young, J J AU - Chen, C-H AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. jchen@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 337 EP - 352 VL - 17 IS - 3 SN - 1062-936X, 1062-936X KW - Receptors, Estrogen KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Discriminant Analysis KW - Colonic Neoplasms -- genetics KW - Computer Simulation KW - Logistic Models KW - Artificial Intelligence KW - Humans KW - Decision Trees KW - Liver Neoplasms -- chemically induced KW - Databases, Factual KW - Algorithms KW - Receptors, Estrogen -- metabolism KW - Monte Carlo Method KW - Structure-Activity Relationship KW - Classification KW - Decision Support Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68600916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+environmental+research&rft.atitle=Decision+threshold+adjustment+in+class+prediction.&rft.au=Chen%2C+J+J%3BTsai%2C+C-A%3BMoon%2C+H%3BAhn%2C+H%3BYoung%2C+J+J%3BChen%2C+C-H&rft.aulast=Chen&rft.aufirst=J&rft.date=2006-06-01&rft.volume=17&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+environmental+research&rft.issn=1062936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-occurring disorders of adolescents in primary care: closing the gaps. AN - 68595486; 16814702 AB - The increasing prevalence of co-occurring mental health and substance use disorders in adolescents is a serious challenge for the primary care system. The needs of these youth continue to be underrecognized, poorly diagnosed, and inappropriately treated in primary care settings, which are often the first point of contact with the health provider system. This article highlights the need for changes at the clinical, organizational, and policy levels to create a system of care that can effectively identify, refer, treat, and coordinate the care for these adolescents and their families. JF - Adolescent medicine clinics AU - Huang, Larke N AU - Freed, Rachel AU - Espiritu, Rachele C AD - American Institutes for Research, 1000 Thomas Jefferson Street, Washington, DC 20007, USA. Larke.huang@samhsa.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 453 EP - 467 VL - 17 IS - 2 SN - 1547-3368, 1547-3368 KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Mass Screening -- organization & administration KW - Humans KW - Referral and Consultation KW - Diagnosis, Dual (Psychiatry) KW - Adolescent KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Community Mental Health Services -- organization & administration KW - Mental Disorders -- therapy KW - Primary Health Care -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68595486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adolescent+medicine+clinics&rft.atitle=Co-occurring+disorders+of+adolescents+in+primary+care%3A+closing+the+gaps.&rft.au=Huang%2C+Larke+N%3BFreed%2C+Rachel%3BEspiritu%2C+Rachele+C&rft.aulast=Huang&rft.aufirst=Larke&rft.date=2006-06-01&rft.volume=17&rft.issue=2&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Adolescent+medicine+clinics&rft.issn=15473368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adolescent smokers screened for a nicotine replacement treatment trial: correlates of eligibility and enrollment. AN - 68577731; 16801302 AB - The enrollment process determines the study sample and external validity of clinical trial results; however, few reports describe the process and outcome of screening efforts for smoking cessation studies among adolescents. We describe and evaluate a screening protocol to enroll adolescent smokers for a randomized clinical trial of nicotine replacement therapy. Adolescent smokers obtained the recruitment call-in number (1-800-NO-SMOKE) via media and other advertisements. Trained recruitment staff collected information using an internally developed, targeted telephone screening interview, which was used to determine pre-eligibility for the clinical trial. Correlates of qualification and of study enrollment were determined. Among 1,347 adolescents screened, 329 (24.4%) were eligible to participate in the trial. Light smoking (39.1%) and lack of parental support (14.8%) were the biggest contributors to ineligibility. Eligible adolescents were more likely to be female (66.9% vs. 58.2%, p = .0052) and more likely to be European American (63.5% vs. 52.2%, p = .0003). The higher rates of ineligibility for African Americans and boys were partly explained by lower scores on the Fagerström Test for Nicotine Dependence. Of those eligible to participate in the trial, 159 (48.3%) enrolled. Results underscore the need for screening instruments that are measurement-invariant across ethnicities and gender, and for enrollment strategies that maximize inclusion of eligible participants. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Robinson, Miqun L AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - Clinical Pharmacology and Treatment Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services, MD 21224, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 447 EP - 454 VL - 8 IS - 3 SN - 1462-2203, 1462-2203 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Randomized Controlled Trials as Topic -- standards KW - Adolescent KW - Male KW - Female KW - Smoking -- therapy KW - Nicotine -- therapeutic use KW - Eligibility Determination KW - Adolescent Behavior KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68577731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Adolescent+smokers+screened+for+a+nicotine+replacement+treatment+trial%3A+correlates+of+eligibility+and+enrollment.&rft.au=Robinson%2C+Miqun+L%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Robinson&rft.aufirst=Miqun&rft.date=2006-06-01&rft.volume=8&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of workplace aerosol sampling procedures and their relevance to the assessment of beryllium exposures. AN - 68061622; 16767225 AB - Standardized conventions governing the fractions of airborne particles that can penetrate the human head airways, the thoracic airways and the alveolar spaces have been internationally (although not universally) adopted. Several agencies involved in setting limit values for occupational exposure concentrations have taken these conventions into account when considering the appropriate standard for specific chemicals, in order to ensure the standards are biologically relevant. A convention is selected based on the characteristic health effects, and forms the basis of measurement against the limiting concentration value. In order to assess exposure for comparison to this metric or any other purposes, it is necessary to choose a sampler whose performance matches the convention, and protocols have been developed and used to test sampler performance. Several aerosol sampling devices are available, nominally at least, for each of the conventions. Some considerations important to the sampling of airborne particles containing beryllium with regard to the sampling conventions, the test protocols and sampler performance are discussed. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 598 EP - 604 VL - 8 IS - 6 SN - 1464-0325, 1464-0325 KW - Aerosols KW - 0 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Inhalation Exposure KW - Humans KW - Occupational Exposure KW - Beryllium -- administration & dosage KW - Workplace UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68061622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=A+review+of+workplace+aerosol+sampling+procedures+and+their+relevance+to+the+assessment+of+beryllium+exposures.&rft.au=Harper%2C+Martin&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2006-06-01&rft.volume=8&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States. AN - 68047888; 16294364 AB - To estimate the number of acetaminophen-associated overdoses in the United States and identify possible risk factors for intervention. The investigators obtained estimates of acetaminophen-associated overdoses using different national databases. Two emergency room databases, a hospital discharge database, a national mortality file, and a poison surveillance database were used to identify cases. The FDA's spontaneous reporting system was searched to identify possible root causes for overdoses. Analysis of national databases show that acetaminophen-associated overdoses account for about 56,000 emergency room visits and 26,000 hospitalizations yearly. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. The poison surveillance database showed near-doubling in the number of fatalities associated with acetaminophen from 98 in 1997 to 173 in 2001. AERS data describe a number of possible causes for unintentional acetaminophen-associated overdoses. Each year a substantial numbers of Americans experience intentional and unintentional acetaminophen-associated overdoses that, in severe cases, lead to serious illness and possible death. This summary of a series of analyses highlights the need for strategies to reduce this public health burden. Copyright (c) 2005 John Wiley & Sons, Ltd JF - Pharmacoepidemiology and drug safety AU - Nourjah, Parivash AU - Ahmad, Syed Rizwanuddin AU - Karwoski, Claudia AU - Willy, Mary AD - Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. NOURJAHP@CDER.FDA.GOV Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 398 EP - 405 VL - 15 IS - 6 SN - 1053-8569, 1053-8569 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - United States KW - Hospitals -- statistics & numerical data KW - Humans KW - Aged KW - Child KW - Poison Control Centers -- statistics & numerical data KW - Adult KW - Drug Overdose KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Databases, Factual KW - Emergency Service, Hospital -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Acetaminophen -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68047888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Estimates+of+acetaminophen+%28Paracetomal%29-associated+overdoses+in+the+United+States.&rft.au=Nourjah%2C+Parivash%3BAhmad%2C+Syed+Rizwanuddin%3BKarwoski%2C+Claudia%3BWilly%2C+Mary&rft.aulast=Nourjah&rft.aufirst=Parivash&rft.date=2006-06-01&rft.volume=15&rft.issue=6&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pharmacoepidemiol Drug Saf. 2006 Jun;15(6):406-9 [16739246] Pharmacoepidemiol Drug Saf. 2006 Jun;15(6):410-1 [16739243] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental exposure assessment of pesticides in farmworker homes. AN - 68043971; 16759997 AB - Farmworkers and their families are exposed to pesticides both at work and in their homes. Environmental exposure assessment provides a means to evaluate pesticides in the environment and human contact with these chemicals through identification of sources and routes of exposure. To date, a variety of methods have been used to assess pesticide exposure among farmworker families, mostly focusing on dust and handwipe samples. While many of the methods are similar, differences in the collection, chemical analysis, and statistical analysis, can limit the comparability of results from farmworker studies. This mini-monograph discusses the strategies used to assess pesticide exposures, presents limitations in the available data for farmworkers, and suggests research needs for future studies of pesticide exposure among farmworker families. JF - Environmental health perspectives AU - Hoppin, Jane A AU - Adgate, John L AU - Eberhart, Monty AU - Nishioka, Marcia AU - Ryan, P Barry AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. hoppin1@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 929 EP - 935 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Index Medicus KW - Water Supply -- analysis KW - Humans KW - Food Analysis KW - Food Contamination KW - Population Surveillance KW - Agriculture KW - Environmental Exposure KW - Family KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68043971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+exposure+assessment+of+pesticides+in+farmworker+homes.&rft.au=Hoppin%2C+Jane+A%3BAdgate%2C+John+L%3BEberhart%2C+Monty%3BNishioka%2C+Marcia%3BRyan%2C+P+Barry&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):494-501 [10554151] Environ Health Perspect. 2006 Jun;114(6):943-52 [16759999] J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):521-9 [10554154] J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):145-58 [10791596] J Air Waste Manag Assoc. 2001 Mar;51(3):339-51 [11266098] Environ Health Perspect. 2001 Feb;109(2):145-50 [11266324] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):231-52 [11477521] Bull Environ Contam Toxicol. 2001 Dec;67(6):771-9 [11692189] Bull Environ Contam Toxicol. 2001 Dec;67(6):780-6 [11692190] Bull Environ Contam Toxicol. 2001 Dec;67(6):787-94 [11692191] Environ Health Perspect. 2001 Nov;109(11):1185-91 [11713005] J Expo Anal Environ Epidemiol. 2001 Nov-Dec;11(6):501-9 [11791166] J AOAC Int. 2002 Jan-Feb;85(1):36-43 [11878617] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] Rev Environ Contam Toxicol. 2002;175:1-46 [12206053] J Expo Anal Environ Epidemiol. 2003 Mar;13(2):100-11 [12679790] J Expo Anal Environ Epidemiol. 2003 May;13(3):203-10 [12743614] Environ Health Perspect. 2003 Oct;111(13):1640-8 [14527844] Environ Health Perspect. 2004 Mar;112(3):382-7 [14998757] Annu Rev Public Health. 2004;25:155-97 [15015917] Environ Health Perspect. 2004 Apr;112(5):636-42 [15064174] J Expo Anal Environ Epidemiol. 1991 Jan;1(1):11-30 [1824309] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] Arch Environ Contam Toxicol. 1994 Jan;26(1):47-59 [8110023] Am Ind Hyg Assoc J. 1994 May;55(5):425-32 [7516116] J Expo Anal Environ Epidemiol. 1994 Jan-Mar;4(1):49-63 [7894268] Am J Public Health. 1995 Aug;85(8 Pt 1):1168 [7625524] Environ Health Perspect. 1995 Apr;103 Suppl 3:13-29 [7635107] J Expo Anal Environ Epidemiol. 1995 Jan-Mar;5(1):21-34 [7663147] Arch Environ Contam Toxicol. 1996 Jan;30(1):132-8 [8579382] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] Environ Health Perspect. 1996 Feb;104(2):202-9 [8820589] Bull Environ Contam Toxicol. 1997 May;58(5):681-7 [9115128] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Occup Med. 1997 Apr-Jun;12(2):221-37 [9220483] Environ Health Perspect. 1998 Jan;106(1):9-16 [9417768] Environ Health Perspect. 1998 Jun;106 Suppl 3:827-32 [9646045] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 1998 Nov;106(11):725-31 [9799188] Environ Health Perspect. 1999 Jun;107(6):463-7 [10339446] J Expo Anal Environ Epidemiol. 2005 Jan;15(1):1-5 [15562291] Scand J Work Environ Health. 2005;31 Suppl 1:33-8; discussion 5-7 [16190147] Environ Health Perspect. 2006 Jun;114(6):923-8 [16759996] Environ Health Perspect. 2006 Jun;114(6):936-42 [16759998] J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):513-20 [10554153] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proximity to crops and residential exposure to agricultural herbicides in iowa. AN - 68043272; 16759991 AB - Rural residents can be exposed to agricultural pesticides through the proximity of their homes to crop fields. Previously, we developed a method to create historical crop maps using a geographic information system. The aim of the present study was to determine whether crop maps are useful for predicting levels of crop herbicides in carpet dust samples from residences. From homes of participants in a case-control study of non-Hodgkin lymphoma in Iowa (1998-2000), we collected vacuum cleaner dust and measured 14 herbicides with high use on corn and soybeans in Iowa. Of 112 homes, 58% of residences had crops within 500 m of their home, an intermediate distance for primary drift from aerial and ground applications. Detection rates for herbicides ranged from 0% for metribuzin and cyanazine to 95% for 2,4-dichlorophenoxyacetic acid. Six herbicides used almost exclusively in agriculture were detected in 28% of homes. Detections and concentrations were highest in homes with an active farmer. Increasing acreage of corn and soybean fields within 750 m of homes was associated with significantly elevated odds of detecting agricultural herbicides compared with homes with no crops within 750 m (adjusted odds ratio per 10 acres = 1.06; 95% confidence interval, 1.02-1.11). Herbicide concentrations also increased significantly with increasing acreage within 750 m. We evaluated the distance of crop fields from the home at < 100, 101-250, 251-500, and 501-750 m. Including the crop buffer distance parameters in the model did not significantly improve the fit compared with a model with total acres within 750 m. Our results indicate that crop maps may be a useful method for estimating levels of herbicides in homes from nearby crop fields. JF - Environmental health perspectives AU - Ward, Mary H AU - Lubin, Jay AU - Giglierano, James AU - Colt, Joanne S AU - Wolter, Calvin AU - Bekiroglu, Nural AU - Camann, David AU - Hartge, Patricia AU - Nuckols, John R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. wardm@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 893 EP - 897 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Herbicides KW - 0 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Iowa KW - Crops, Agricultural KW - Environmental Exposure KW - Herbicides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68043272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Proximity+to+crops+and+residential+exposure+to+agricultural+herbicides+in+iowa.&rft.au=Ward%2C+Mary+H%3BLubin%2C+Jay%3BGiglierano%2C+James%3BColt%2C+Joanne+S%3BWolter%2C+Calvin%3BBekiroglu%2C+Nural%3BCamann%2C+David%3BHartge%2C+Patricia%3BNuckols%2C+John+R&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Jan;108(1):5-12 [10622770] J Occup Environ Hyg. 2005 Jul;2(7):357-67 [16020099] Epidemiology. 2001 Mar;12(2):148-56 [11246574] J Expo Anal Environ Epidemiol. 2001 Jan-Feb;11(1):56-65 [11246803] J Environ Qual. 2001 May-Jun;30(3):697-701 [11401259] Environ Health Perspect. 2002 Mar;110(3):319-24 [11882484] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] Environ Health Perspect. 2002 Dec;110(12):1175-84 [12460795] Environ Health Perspect. 2002 Dec;110(12):A787-92 [12460819] Environ Health Perspect. 2003 Oct;111(13):1582-9 [14527836] Environ Sci Technol. 2003 Oct 15;37(20):4543-53 [14594359] J Expo Anal Environ Epidemiol. 2004 Jan;14(1):74-83 [14726946] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Epidemiology. 2005 Jul;16(4):542-7 [15951673] Environ Res. 2000 Nov;84(3):290-302 [11097803] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. AN - 68021461; 16497704 AB - The field of cancer epigenetics has received much attention in recent years. However, the relationship of cancer epigenetics with cancer etiology is not clear. Recent studies suggest the involvement of altered DNA methylation and histone modifications in the emergence of epigenetically reprogrammed cells with specific tumor-related phenotypes at premalignant stages of tumor development. In this study, we used a methyl-deficient model of rodent hepatocarcinogenesis to examine the roles of DNA, histone H3 lysine 9 and histone H4 lysine 20 methylation, and the level of the expression of Suv39h1 and Suv4-20h2 histone methyltransferases in the carcinogenic process. We demonstrated that the development of liver tumors was characterized by progressive demethylation of DNA repeats, decrease in histone H4 lysine 20 trimethylation, and a gradual decrease in the expression of Suv4-20h2 histone methyltransferase. A prominent increase in the trimethylation of histone H3 lysine 9 and in the expression of Suv39h1 histone methyltransferase was observed in preneoplastic nodules and liver tumors indicating the promotional role of these epigenetic alterations at later stages of carcinogenesis. The appearance of tumor-specific epigenetic alterations (demethylation of repetitive elements, loss of histone H4 lysine 20 trimethylation, altered expression of Suv4-20h2 and Suv39h1 histone methyltransferases) at preneoplastic stages of hepatocarcinogenesis provides experimental support for the epigenetic hypothesis of tumorigenesis that considers stress-induced epigenetic reprogramming of the cell as an important prerequisite to succeeding mutations. JF - Carcinogenesis AU - Pogribny, Igor P AU - Ross, Sharon A AU - Tryndyak, Volodymyr P AU - Pogribna, Marta AU - Poirier, Lionel A AU - Karpinets, Tatiana V AD - National Center for Toxicological Research, Jefferson, AR 72078, National Cancer Institute, Bethesda, MD 20892 and University of Tennessee, Knoxville, TN 37996, USA. ipogribny@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1180 EP - 1186 VL - 27 IS - 6 SN - 0143-3334, 0143-3334 KW - Histones KW - 0 KW - Repressor Proteins KW - Suv39h1 protein, mouse KW - EC 2.1.1. KW - Suv39h1 protein, rat KW - Methyltransferases KW - EC 2.1.1.- KW - Protein Methyltransferases KW - histone methyltransferase KW - Suv4-20h2 protein, rat KW - EC 2.1.1.125 KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Long Interspersed Nucleotide Elements KW - DNA Methylation KW - Epigenesis, Genetic KW - Mutation KW - Methylation KW - Male KW - Repressor Proteins -- biosynthesis KW - Liver Neoplasms -- metabolism KW - Histones -- metabolism KW - Histones -- chemistry KW - Methyltransferases -- chemistry KW - Methyltransferases -- biosynthesis KW - Histone-Lysine N-Methyltransferase -- chemistry KW - Repressor Proteins -- chemistry KW - Histone-Lysine N-Methyltransferase -- metabolism KW - Histone-Lysine N-Methyltransferase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68021461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Histone+H3+lysine+9+and+H4+lysine+20+trimethylation+and+the+expression+of+Suv4-20h2+and+Suv-39h1+histone+methyltransferases+in+hepatocarcinogenesis+induced+by+methyl+deficiency+in+rats.&rft.au=Pogribny%2C+Igor+P%3BRoss%2C+Sharon+A%3BTryndyak%2C+Volodymyr+P%3BPogribna%2C+Marta%3BPoirier%2C+Lionel+A%3BKarpinets%2C+Tatiana+V&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2006-06-01&rft.volume=27&rft.issue=6&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transfusion-related acute lung injury. AN - 68014027; 16728851 JF - The American journal of nursing AU - Knippen, Maureen A AD - Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration in Rockville, MD, USA. maureen.knippen@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 61 EP - 64 VL - 106 IS - 6 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - United States KW - Humans KW - Rare Diseases KW - United States Food and Drug Administration KW - Histocompatibility Testing KW - Adverse Drug Reaction Reporting Systems KW - Risk Factors KW - Adult KW - Practice Guidelines as Topic KW - Nurse's Role KW - Middle Aged KW - Early Diagnosis KW - Time Factors KW - Female KW - Respiratory Distress Syndrome, Adult -- diagnosis KW - Blood Transfusion -- adverse effects KW - Respiratory Distress Syndrome, Adult -- therapy KW - Transplantation, Homologous -- adverse effects KW - Blood Transfusion -- nursing KW - Transplantation, Homologous -- nursing KW - Respiratory Distress Syndrome, Adult -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68014027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Transfusion-related+acute+lung+injury.&rft.au=Knippen%2C+Maureen+A&rft.aulast=Knippen&rft.aufirst=Maureen&rft.date=2006-06-01&rft.volume=106&rft.issue=6&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-23 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. AN - 68004871; 16716128 AB - To analyze the disproportionality of reporting of hyperprolactinemia, galactorrhea, and pituitary tumors with seven widely used antipsychotic drugs. Retrospective pharmacovigilance study. United States Food and Drug Administration's Adverse Event Reporting System (AERS) database. We initially identified higher-than-expected postmarketing reports of pituitary tumors associated with risperidone, a potent dopamine D2-receptor antagonist antipsychotic, by analyzing reporting patterns of these tumors in the AERS database. To further examine this association, we analyzed disproportionate reporting patterns of pituitary tumor reports for seven antipsychotics with different affinities for blocking D2 receptors: aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, and haloperidol. To conduct both of these analyses, we used the Multi-item Gamma Poisson Shrinker (MGPS) data mining algorithm applied to the AERS database. The MGPS uses a Bayesian model to calculate adjusted observed:expected ratios of drug-adverse event associations (Empiric Bayes Geometric Mean [EBGM] values) in huge drug safety databases. The higher the adjusted reporting ratio, or EBGM value, the greater the strength of the association between a drug and an adverse event. Risperidone had the highest adjusted reporting ratios for hyperprolactinemia (EBGM 34.9, 90% confidence interval [CI] 32.8-37.1]), galactorrhea (EBGM 19.9, 90% CI 18.6-21.4), and pituitary tumor (EBGM 18.7, 90% CI 14.9-23.3) among the seven antipsychotics, and one of the highest scores for all drugs in the AERS database. Some tumors were associated with visual field defects, hemorrhage, convulsions, surgery, and severe (>10-fold) prolactin elevations. The EBGM values for risperidone for these adverse events were higher in women, but high EBGM values for these events were also seen in men and children. Moreover, the rank order of the EBGM values for pituitary tumors corresponded to the affinities of these seven drugs for D2 receptors. Treatment with potent D2-receptor antagonists, such as risperidone, may be associated with pituitary tumors. These findings are consistent with animal (mice) studies and raise the need for clinical awareness and longitudinal studies. JF - Pharmacotherapy AU - Szarfman, Ana AU - Tonning, Joseph M AU - Levine, Jonathan G AU - Doraiswamy, P Murali AD - Office of Pharmacoepidemiology and Statistical Sciences, Immediate Office, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. szarfman@cder.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 748 EP - 758 VL - 26 IS - 6 SN - 0277-0008, 0277-0008 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Piperazines KW - Quinolones KW - Thiazoles KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - ziprasidone KW - 6UKA5VEJ6X KW - Aripiprazole KW - 82VFR53I78 KW - Clozapine KW - J60AR2IKIC KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - United States KW - Haloperidol -- adverse effects KW - Quinolones -- adverse effects KW - Galactorrhea -- chemically induced KW - Sex Factors KW - Humans KW - Retrospective Studies KW - Child KW - Thiazoles -- adverse effects KW - Piperazines -- adverse effects KW - Clozapine -- adverse effects KW - United States Food and Drug Administration KW - Dibenzothiazepines -- adverse effects KW - Benzodiazepines -- adverse effects KW - Gynecomastia -- chemically induced KW - Risperidone -- adverse effects KW - Hyperprolactinemia -- chemically induced KW - Adolescent KW - Amenorrhea -- chemically induced KW - Male KW - Female KW - Pituitary Neoplasms -- chemically induced KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68004871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Atypical+antipsychotics+and+pituitary+tumors%3A+a+pharmacovigilance+study.&rft.au=Szarfman%2C+Ana%3BTonning%2C+Joseph+M%3BLevine%2C+Jonathan+G%3BDoraiswamy%2C+P+Murali&rft.aulast=Szarfman&rft.aufirst=Ana&rft.date=2006-06-01&rft.volume=26&rft.issue=6&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pilot measurements of ELF contact currents in some electric utility occupations. AN - 67995704; 16718950 AB - Contact currents from touching objects with different voltages can produce electric fields within the body that produce neurological and other biological effects. To begin measuring these exposures among electric utility workers, a new contact current meter (CCM) was tested in a pilot study at Southern California Edison. The CCM was worn for 82 full-shift measurements by 76 volunteers from eight occupations who did not work directly with energized electrical equipment. The volunteers were exposed to an average of 285.8 contact current events above the meter's 1-microA threshold, but most of these were electrostatic spark discharges. Fourteen employees experienced an average of 135.1 contact currents events whose primary frequency was 60 Hz. Using a circuit model of the human body, the average contact currents going from arm to arm was 9.8 microA (maximum = 178.0 microA), and the average going down the torso was 25.5 microA (maximum = 662.0). The maximum exposures were experienced by a technical support employee working in a substation. All measurements in this pilot study were below the 3000 microA maximum permissible exposure for contact currents set by the Institute of Electrical and Electronic Engineers (IEEE). Combining these current measurements with the results of high-resolution dosimetry, the internal electric fields averaged an estimated 1.7 mV/m in the heart (maximum = 21.0 mV/m), and 1.9 mV/m in the hematopoietic bone marrow in the torso (maximum = 56.5 mV/m). These internal electric fields from contact currents are below the basic restriction of 943 mV/m in the IEEE exposure standards but are above 1 mV/m, a level where biological effects have been often reported in laboratory studies. Safety concerns limited the measurements to de-energized equipment, so we did not obtain data on work in energized high-voltage environments, the most likely sources of high contact currents. This pilot study identified other improvements to the contact current meter that would make it better able to measure exposures in future health studies. JF - Journal of occupational and environmental hygiene AU - Bowman, Joseph AU - Niple, John AU - Kavet, Rob AD - NIOSH Physical Hazards Team, Engineering and Physical Hazards Branch, National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. jdb0@cdc.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 323 EP - 333 VL - 3 IS - 6 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - California KW - Maximum Allowable Concentration KW - Humans KW - Body Burden KW - Pilot Projects KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Electromagnetic Fields KW - Electric Conductivity KW - Occupational Exposure -- standards KW - Electrophysiology -- standards KW - Electrophysiology -- instrumentation KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67995704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Pilot+measurements+of+ELF+contact+currents+in+some+electric+utility+occupations.&rft.au=Bowman%2C+Joseph%3BNiple%2C+John%3BKavet%2C+Rob&rft.aulast=Bowman&rft.aufirst=Joseph&rft.date=2006-06-01&rft.volume=3&rft.issue=6&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-05-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Occup Environ Hyg. 2007 Jul;4(7):D65-6 [17497395] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Focusing in on dose reduction: the FDA perspective. AN - 67994405; 16714664 JF - AJR. American journal of roentgenology AU - Barr, Helen J AU - Ohlhaber, Thomas AU - Finder, Charles AD - Food and Drug Administration, Center for Devices and Radiological Health, Division of Mammography Quality and Radiation Programs, 1350 Piccard Dr., Rockville, MD 20850, USA. helen.barr@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1716 EP - 1717 VL - 186 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Radiation Dosage KW - United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67994405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AJR.+American+journal+of+roentgenology&rft.atitle=Focusing+in+on+dose+reduction%3A+the+FDA+perspective.&rft.au=Barr%2C+Helen+J%3BOhlhaber%2C+Thomas%3BFinder%2C+Charles&rft.aulast=Barr&rft.aufirst=Helen&rft.date=2006-06-01&rft.volume=186&rft.issue=6&rft.spage=1716&rft.isbn=&rft.btitle=&rft.title=AJR.+American+journal+of+roentgenology&rft.issn=1546-3141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. AN - 67980526; 16700620 AB - The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two years. Novel approaches for brain tumor therapy are needed. Recently, targeted therapies have emerged as promising modality for cancer targeting. We have discovered that high affinity plasma membrane receptor for interleukin-13 (IL-13), an immune regulatory cytokine, is over-expressed in 60-80% of malignant brain tumors. To target these IL-13R, we generated a chimeric fusion protein, composed of human IL-13 and mutated Pseudomonas exotoxin (PE), termed IL-13 cytotoxin (IL13-PE), and tested its cytotoxicity to IL-13R-expressing GBM cells. IL-13 cytotoxin was highly potent and selective in killing IL-13R-expressing GBM cells. In contrast, normal cells including brain, immune, and endothelial cells were generally not affected by this cytotoxin due to no or low expression of IL-13R. In vivo pre-clinical studies for safety and toxicity were also performed in mice, rats, and monkeys, and IL-13 cytotoxin was found to be well tolerated by both systemic and intracerebral administrations. IL-13 cytotoxin was found to mediate remarkable efficacy in animal models of human brain tumors. Encouraged by these pre-clinical studies, four Phase 1/2 clinical trials in adult patients with recurrent malignant glioma have been completed. These clinical trials involved convection-enhanced delivery (CED) of IL-13 cytotoxin either intratumoral or intraparenchymal after resection of tumor. CED is a novel loco-regional drug delivery method for intracranial tumors that relies on a continuous pressure gradient to distribute drug into interstitial space. This route of IL-13 cytotoxin administration appears to be very well tolerated and have a good risk-benefit profile. Most recently, a randomized controlled Phase 3 clinical trial (PRECISE) with intraparenchymal IL-13 cytotoxin administration was completed and subjects are being monitored for safety and survival. JF - Technology in cancer research & treatment AU - Kioi, Mitomu AU - Husain, Syed R AU - Croteau, David AU - Kunwar, Sandeep AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 239 EP - 250 VL - 5 IS - 3 SN - 1533-0346, 1533-0346 KW - Exotoxins KW - 0 KW - IL13-PE38QQR KW - IL13RA1 protein, human KW - Interleukin-13 KW - Interleukin-13 Receptor alpha1 Subunit KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Index Medicus KW - Animals KW - Receptors, Interleukin -- metabolism KW - Humans KW - Clinical Trials as Topic KW - Convection KW - Interleukin-13 -- administration & dosage KW - Drug Delivery Systems KW - Exotoxins -- administration & dosage KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Interleukin-13 -- therapeutic use KW - Brain Neoplasms -- metabolism KW - Exotoxins -- toxicity KW - Glioma -- metabolism KW - Exotoxins -- therapeutic use KW - Interleukin-13 -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67980526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technology+in+cancer+research+%26+treatment&rft.atitle=Convection-enhanced+delivery+of+interleukin-13+receptor-directed+cytotoxin+for+malignant+glioma+therapy.&rft.au=Kioi%2C+Mitomu%3BHusain%2C+Syed+R%3BCroteau%2C+David%3BKunwar%2C+Sandeep%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2006-06-01&rft.volume=5&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Technology+in+cancer+research+%26+treatment&rft.issn=15330346&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Bone marrow dose estimates from work-related medical x-ray examinations given between 1943 and 1966 for personnel from five U.S. nuclear facilities. AN - 67965412; 16691102 AB - Inclusion of dose from work-related medical x-ray examinations with occupational external dose in an epidemiological study may reduce misclassification of exposures and provide more accurate assessment of leukemia risk from occupational exposure to ionizing radiation. In a multi-site leukemia case-control study, annual bone marrow doses due to work-related x-ray examinations given between 1943 and 1966 were estimated for cases and controls employed at five nuclear facilities. Only active bone marrow dose from photofluorographic chest and routine lumbar spine x rays were included. Bone marrow dose assigned for a single exposure ranged from 1.0 to 1.4 mGy. Mean and median cumulative bone marrow doses for each of the five sites from work-related x-ray examinations ranged from 2.0 to 14 mGy and 2.1 to 8.8 mGy, respectively. Results suggest that bone marrow dose from work-related photofluorographic and lumbar spine x-ray examinations given during the time period of this study may be significant compared to occupational bone marrow dose. JF - Health physics AU - Anderson, Jeri L AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, PHS/DHHS, 4676 Columbia Pkwy, Mail Stop R-44, Cincinnati, OH 45226, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 544 EP - 553 VL - 90 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Risk Factors KW - Humans KW - Body Burden KW - United States -- epidemiology KW - Bone Marrow KW - Radiation Monitoring -- methods KW - Nuclear Reactors -- statistics & numerical data KW - Power Plants -- statistics & numerical data KW - Radiography -- statistics & numerical data KW - Risk Assessment -- methods KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67965412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Bone+marrow+dose+estimates+from+work-related+medical+x-ray+examinations+given+between+1943+and+1966+for+personnel+from+five+U.S.+nuclear+facilities.&rft.au=Anderson%2C+Jeri+L%3BDaniels%2C+Robert+D&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2006-06-01&rft.volume=90&rft.issue=6&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-08 N1 - Date created - 2006-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of Dithiocarbamates in Agricultural Products Circulated in Korea AN - 21292726; 12537009 AB - To revise the dithiocarbamates residue analysis method and survey the residues in agricultural products that were treated with these fungicides in Korea, we purchased 20 types of foodstuffs (rice, potato, cabbage, apple etc.) from markets in five major cities. 236 samples of the purchased foodstuffs were then analyzed for the presence of dithiocarbamates by HPLC/UV and HPLC/APCI-MS. The R super(2), LOD and LOQ in the range of 0.5-107.3 mg/L were as follows: DCC: y=174.34x+18.315, R super(2)=0.9999, 0.01 mg/L, and 0.04 mg/L; EBDC: y=227.38x-14.715, R super(2)=1.0000, 0.01 mg/L and 0.02 mg/L; PBDC: y=38.46x-21.412, R super(2)=0.9999, 0.04 mg/L, and 0.1 mg/L; ETU: y=52.752x-4.4819, R super(2)=0.9-998, 0.02 mg/L and 0.03 mg/L; PTU: y=128.28x+4.4624, R super(2)=0.9998, 0.02 mg/L, and 0.04 mg/L. The levels of DDC, EBDC, PBDC, ETU and PTU in 20 agricultural products fortified to 10.0-107.3 mg/L ranged from 61.7-117.5%, 65.3-110.1%, 61.5-109.6%, 69.3-116.3% and 70.2-97.2%, respectively. Overall, dithiocarbamates were detected in 100 samples and the detection ratio was 42.4%. Among these, only 3 samples (1.3%) of Lycii fructus had residue levels that were above the action limits, while the remaining samples (233 samples) contained levels of dithiocarbamates below the detection limit or below the Korea MRLs (Maximum Residue Limits). JF - Korean Journal of Food Science and Technology AU - Kim, H-Y AU - Choi, H-J AU - Eom, J-Y AU - Seo, E-C AU - Choi, S-H AU - Cheong, S-Y AU - Lee, H-J AU - Choi, J-C AD - Gyeongin Regional Korea Food and Drug Administration, Incheon 402-835, Korea, chjatu@kfda.go.kr Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1 EP - 7 VL - 38 IS - 3 SN - 0367-6293, 0367-6293 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Solanum tuberosum KW - Food KW - Agricultural products KW - Fungicides KW - Malus KW - Oryza sativa KW - Brassica KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21292726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Determination+of+Dithiocarbamates+in+Agricultural+Products+Circulated+in+Korea&rft.au=Kim%2C+H-Y%3BChoi%2C+H-J%3BEom%2C+J-Y%3BSeo%2C+E-C%3BChoi%2C+S-H%3BCheong%2C+S-Y%3BLee%2C+H-J%3BChoi%2C+J-C&rft.aulast=Kim&rft.aufirst=H-Y&rft.date=2006-06-01&rft.volume=38&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Food; Fungicides; Agricultural products; Solanum tuberosum; Oryza sativa; Malus; Brassica ER - TY - JOUR T1 - Steady State Pharmacokinetics of Oral Treatment with 13-cis-Retinoic Acid or all-trans-Retinoic Acid in Male and Female Adult Rats AN - 21035317; 6881562 AB - Male and female Sprague-Dawley rats were orally gavaged with 13-cis-retinoic acid (7.5 or 15 mg-kg) or all-trans-retinoic acid (10 or 15 mg-kg) for 7 consecutive days. Blood was collected out to 8 hr after the last gavage on day 7. HPLC serum concentrations of 13-cis-retinoic acid, all-trans-retinoic acid, and 13-cis-4-oxo-retinoic acid were subjected to model independent pharmacokinetic analyses. Peak serum levels of 563 to 1640 ng-ml were observed for rats treated with 13-cis-retinoic acid at 1.5-2 hr after gavage. Peak serum levels of 183 to 267 ng-ml at 1.5 hr after gavage were observed for all-trans-retinoic acids. The elimination half-life of 13-cis-retinoic acid was about 1.5 hr while the elimination half-life of all-trans-retinoic acid was slightly longer. There were no sex differences for any parameter. Serum levels resulting from the 7.5 mg-kg 13-cis-retinoic acid were similar to those of human Accutane super( registered ) users. JF - Basic & Clinical Pharmacology & Toxicology AU - Ferguson, Sherry A AU - Siitonen, Paul H AU - Cisneros, FJavier AU - Gough, Bobby AU - Young, John F AD - Division of Neurotoxicology, sferguson@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 582 EP - 587 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 98 IS - 6 SN - 1742-7835, 1742-7835 KW - Toxicology Abstracts KW - Serum levels KW - High-performance liquid chromatography KW - Blood KW - Retinoic acid KW - Sex differences KW - Pharmacokinetics KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.atitle=Steady+State+Pharmacokinetics+of+Oral+Treatment+with+13-cis-Retinoic+Acid+or+all-trans-Retinoic+Acid+in+Male+and+Female+Adult+Rats&rft.au=Ferguson%2C+Sherry+A%3BSiitonen%2C+Paul+H%3BCisneros%2C+FJavier%3BGough%2C+Bobby%3BYoung%2C+John+F&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2006-06-01&rft.volume=98&rft.issue=6&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.issn=17427835&rft_id=info:doi/10.1111%2Fj.1742-7843.2006.pto_359.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Tables, 1; references, 31. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Serum levels; Blood; Retinoic acid; Sex differences; Pharmacokinetics; Models DO - http://dx.doi.org/10.1111/j.1742-7843.2006.pto_359.x ER - TY - JOUR T1 - The advisory process for anticancer drug regulation: a global perspective AN - 20246829; 6945035 AB - PURPOSE: This paper summarizes the role of external advisors in oncology drug development and regulation from a global perspective. DESIGN: Recently, representatives from the United States Food and Drug Administration, European Medicines Agency, the Japanese Pharmaceuticals and Medical Devices Agency, the Australian Therapeutic Goods Administration and Health Canada held a meeting in conjunction with the American Society of Clinical Oncology meeting. The role of external advisors in oncology drug development and regulation in each of these jurisdictions was presented and discussed. RESULTS: All regulatory bodies described have experience with two forms of outside expertise: advice from individual experts and advice from a group of experts assembled as an advisory group. Regulatory jurisdictions use individual experts variably. In some regions, individual experts provide advice based on knowledge and experience during the drug development phase or in the planning phase for the submission of a drug registration package. In other regions, these individuals serve as external evaluators with the primary responsibility for the review of a clinical trials package submitted for drug registration. Advisory boards have been formalized in all jurisdictions discussed. Advisory boards have a role in discussing specific applications as well as broad policy issues. A common theme is a composition of a core panel of experts with augmentation by additional expertise as needed for consideration of specific scientific questions. In all jurisdictions, advisory board recommendations are not binding on the regulatory body. CONCLUSIONS: Global oncology drug development and registration involves the use of experts by regulatory authorities. The types of experts needed, the expert's role and the transparency of the advisory process reflect the individual needs in different regions. JF - Annals of Oncology AU - Farrell, A T AU - Papadouli, I AU - Hori, A AU - Harczy, M AU - Harrison, B AU - Asakura, W AU - Marty, M AU - Dagher, R AU - Pazdur, R AD - United States Food and Drug Administration, Center for Drug Evaluation and Research Office of New Drugs, Office of Oncology Drug Products, Division of Drug Oncology Products, Silver Spring, MD, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 889 EP - 896 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 17 IS - 6 SN - 0923-7534, 0923-7534 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Pharmaceuticals KW - Drug development KW - Oncology KW - Antitumor agents KW - Clinical trials KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20246829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=The+advisory+process+for+anticancer+drug+regulation%3A+a+global+perspective&rft.au=Farrell%2C+A+T%3BPapadouli%2C+I%3BHori%2C+A%3BHarczy%2C+M%3BHarrison%2C+B%3BAsakura%2C+W%3BMarty%2C+M%3BDagher%2C+R%3BPazdur%2C+R&rft.aulast=Farrell&rft.aufirst=A&rft.date=2006-06-01&rft.volume=17&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Pharmaceuticals; Oncology; Drug development; Clinical trials; Antitumor agents ER - TY - JOUR T1 - MicroRNAs and cell differentiation in mammalian development AN - 20205879; 7596922 AB - MicroRNAs (miRNAs) are a group of recently discovered small RNAs produced by the cell using a unique process, involving RNA polymerase II, Microprocessor protein complex, and the RNAase III/Dicer endonuclease complex, and subsequently sequestered in an miRNA ribonucleoprotein complex. The biological functions of miRNAs depend on their ability to silence gene expression, primarily via degradation of the target mRNA and/or translational suppression, mediated by the RNA-induced silencing complex (RISC). First discovered in Caenorhabditis elegans (lin-4), miRNAs have now been identified in a wide array of organisms, including plants, zebrafish, Drosophila, and mammals. The expression of miRNAs in multicellular organisms exhibits spatiotemporal, and tissue- and cell-specificity, suggesting their involvement in tissue morphogenesis and cell differentiation. More than 200 miRNAs have been identified or predicted in mammalian cells. Recent studies have demonstrated the importance of miRNAs in embryonic stem cell differentiation, limb development, adipogenesis, myogenesis, angiogenesis and hematopoiesis, neurogenesis, and epithelial morphogenesis. Overexpression (gain-of-function) and inactivation (loss-of-function) are currently the primary approaches to studying miRNA functions. Another family of small RNAs related to miRNAs is the small interfering RNAs (siRNAs), generated by Dicer from long double-stranded RNAs (dsRNAs), and produced from an induced transgene, a viral intruder, or a rogue genetic element. siRNAs silence genes via either mRNA degradation, using the RISC, or DNA methylation. siRNAs are actively being applied in basic, functional genetic studies, particularly in the generation of gene knockdown animals, as well as in gene knockdown studies of cultured cells. These studies have provided invaluable information on the specific function(s) of individual genes. siRNA technology also presents exciting potential as a therapeutic approach in disease prevention and treatment, as suggested by a recent study targeting apolipoprotein B (ApoB) in primates. Further elucidation of how miRNAs and other small RNAs interact with known and yet-to-be identified gene regulatory pathways in the cell should provide us with a more in-depth understanding of the mechanisms regulating cellular function and differentiation, and facilitate the application of small RNA technology in disease control and treatment. Birth Defects Research (Part C) 78:140-149, 2006. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Song, Lin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch of the National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, tuanr@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 140 EP - 149 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 78 IS - 2 SN - 1542-975X, 1542-975X KW - Zebra danio KW - Zebra fish KW - Entomology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - myogenesis KW - Translation KW - Apolipoprotein B KW - Double-stranded RNA KW - Morphogenesis KW - Disease control KW - Angiogenesis KW - Gene expression KW - Differentiation KW - DNA-directed RNA polymerase KW - Stem cells KW - Neurogenesis KW - Mammalian cells KW - Embryo cells KW - Caenorhabditis elegans KW - DNA methylation KW - Congenital defects KW - RNA-induced silencing complex KW - Endonuclease KW - adipogenesis KW - miRNA KW - Transgenes KW - Primates KW - Danio rerio KW - Intruder KW - Limbs KW - siRNA KW - Ribonucleoproteins KW - Hemopoiesis KW - Drosophila KW - Gene silencing KW - W 30925:Genetic Engineering KW - Z 05360:Genetics and Evolution KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20205879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=MicroRNAs+and+cell+differentiation+in+mammalian+development&rft.au=Song%2C+Lin%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-06-01&rft.volume=78&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - myogenesis; Translation; Apolipoprotein B; Double-stranded RNA; Morphogenesis; Angiogenesis; Disease control; Gene expression; Differentiation; Neurogenesis; Stem cells; DNA-directed RNA polymerase; Embryo cells; Mammalian cells; DNA methylation; Congenital defects; RNA-induced silencing complex; adipogenesis; Endonuclease; Transgenes; miRNA; Intruder; Limbs; siRNA; Ribonucleoproteins; Hemopoiesis; Gene silencing; Danio rerio; Caenorhabditis elegans; Primates; Drosophila DO - http://dx.doi.org/10.1002/bdrc.20069 ER - TY - JOUR T1 - Glucocorticoids Promote Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells by Enhancing Expression of Cartilage Extracellular Matrix Genes AN - 19986137; 6999317 AB - In the adult human, mesenchymal stem cells (hMSCs) resident in the bone marrow retain the capacity to proliferate and differentiate along multiple connective tissue lineages, including cartilage. Glucocorticoids (GCs) are required for chondrogenic differentiation of hMSCs in vitro; however, the exact role of GCs in this process is not known. In this study, we examined the effects of dexamethasone (DEX) on chondrogenic differentiation of hMSCs in the presence or absence of DEX, transforming growth factor-{szligbeta} (TGF-{szligbeta}), or DEX plus TGF-{szligbeta}. GC treatment upregulated gene expression of cartilage matrix components aggrecan, dermatopontin, and collagen type XI; enhanced TGF-{szligbeta}-mediated upregulation of collagen type II and cartilage oligomeric matrix protein; and increased aggrecan and collagen type II production as well as cartilage matrix-sulfated proteoglycans as assessed by immunohistochemistry and alcian blue staining. Inclusion of an antagonist of GCs inhibited expression of chondrogenic differentiation markers, suggesting that the GC effects during chondrogenesis are mediated by the GC receptor (GR). Steady levels of the major active form of GR, GR alpha , were detected in both undifferentiated and differentiating hMSCs, whereas the dominant-negative isoform GR{szligbeta}, present at low levels in undifferentiated hMSCs, was downregulated during chondrogenesis. In the presence of DEX and TGF-{szligbeta}, expression of a collagen type II gene promoter luciferase reporter construct in hMSCs was upregulated. However, coexpression of GR{szligbeta} dramatically inhibited promoter activity, suggesting that GR alpha is required for GC-mediated modulation of chondrogenesis and that GCs may play an important role in the maintenance of cartilage homeostasis. JF - Stem Cells AU - Derfoul, Assia AU - Perkins, Geraldine L AU - Hall, David J AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, Cartilage Genetics Group, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1487 EP - 1495 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Calcium & Calcified Tissue Abstracts KW - Cartilage oligomeric matrix protein KW - Dexamethasone KW - Connective tissues KW - Cartilage KW - Bone marrow KW - Glucocorticoids KW - Proteoglycans KW - Promoters KW - Stem cells KW - Extracellular matrix KW - Collagen (type II) KW - aggrecan KW - Mesenchyme KW - Immunohistochemistry KW - Chondrogenesis KW - G 07880:Human Genetics KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Glucocorticoids+Promote+Chondrogenic+Differentiation+of+Adult+Human+Mesenchymal+Stem+Cells+by+Enhancing+Expression+of+Cartilage+Extracellular+Matrix+Genes&rft.au=Derfoul%2C+Assia%3BPerkins%2C+Geraldine+L%3BHall%2C+David+J%3BTuan%2C+Rocky+S&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Cartilage oligomeric matrix protein; Connective tissues; Cartilage; Bone marrow; Glucocorticoids; Proteoglycans; Promoters; Stem cells; Extracellular matrix; Collagen (type II); Mesenchyme; aggrecan; Immunohistochemistry; Chondrogenesis ER - TY - JOUR T1 - In vitro antimicrobial susceptibility, genetic diversity and prevalence of UDP-glucose 4-epimerase (galE) gene in Campylobacter coli and Campylobacter jejuni from Turkey production facilities AN - 19980911; 6742834 AB - This study evaluated the genetic diversity of multi-drug resistant Campylobacter jejuni (n=44) and C. coli (n=30) isolated from 18 turkey houses. Antimicrobial resistances to ampicillin, ciprofloxacin and nalidixic acid were higher (P<0.05) in C. coli than in C. jejuni strains. PCR analysis indicated that 82% of total isolates tested, including 91% of C. jejuni and 70% of C. coli tested positive for a 496-bp UDP-glucose 4-epimerase (galE) gene. The diversity of isolates was mapped by antibiogram, SmaI-PFGE and flaA-RFLP typing methods using the discriminatory index (DI). RFLP was more suitable in discriminating C. coli (DI=0.895) than PFGE (DI=0.816) or antibiogram profile (DI=0.552), while either PFGE (DI=0.941) or RFLP (DI=0.942) could be used in discriminating C. jejuni strains. The combined PFGE and antibiogram dendrogram had the highest DI for both C. coli (0.910) and C. jejuni (0.968), suggesting that a combination of typing methods is more useful in examining the diverse Campylobacter population on turkey farms. JF - Food Microbiology AU - Nayak, R AU - Stewart, T AU - Nawaz, M AU - Cerniglia, C AD - National Center for Toxicological Research, Division of Microbiology, 3900 NCTR Road, Jefferson, AR 72079, USA, rnayak@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 379 EP - 392 VL - 23 IS - 4 SN - 0740-0020, 0740-0020 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Poultry KW - Houses KW - Farms KW - Campylobacter coli KW - Genetic diversity KW - Ampicillin KW - Microbial contamination KW - Antimicrobial agents KW - Ciprofloxacin KW - Typing KW - Food processing industry KW - Campylobacter jejuni KW - Nalidixic acid KW - Polymerase chain reaction KW - Multidrug resistance KW - Antibiotic resistance KW - J 02310:Genetics & Taxonomy KW - A 01064:Microbial resistance KW - G 07770:Bacteria KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=In+vitro+antimicrobial+susceptibility%2C+genetic+diversity+and+prevalence+of+UDP-glucose+4-epimerase+%28galE%29+gene+in+Campylobacter+coli+and+Campylobacter+jejuni+from+Turkey+production+facilities&rft.au=Nayak%2C+R%3BStewart%2C+T%3BNawaz%2C+M%3BCerniglia%2C+C&rft.aulast=Nayak&rft.aufirst=R&rft.date=2006-06-01&rft.volume=23&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2005.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ciprofloxacin; Houses; Farms; Typing; Nalidixic acid; Ampicillin; Polymerase chain reaction; Genetic diversity; Multidrug resistance; Antibiotic resistance; Antimicrobial agents; Poultry; Food processing industry; Microbial contamination; Campylobacter jejuni; Campylobacter coli DO - http://dx.doi.org/10.1016/j.fm.2005.04.007 ER - TY - JOUR T1 - Using PCR amplification to increase the confidence level of Salmonella typhimurium DNA microarray chip hybridization AN - 19969191; 6822923 AB - In order to design and validate a method to identify virulence genes of Salmonella typhimurium using DNA microarray, a protocol was developed to label the isolated bacterial DNA directly and to use PCR amplification of limited numbers of genes to validate the hybridization signals. Therefore, a DNA microarray chip of 71 virulence genes of S. typhimurium was developed and evaluated using 10 isolates. Each gene was represented by 65 bp oligonucleotide probes (oligoprobes) and immobilized on the surface of chemically modified slides. Whole DNA genomes were digested with Hinf1 and Sau3AI, labeled with a fluorescent tag of Cy3 and then hybridized. The presence of virulence genes in 10 strains of S. typhimurium was established by measuring a fluorescent signal above the background noise of the chip. PCR amplification of 10 genes (orgA, ORF319, ttrB, rmbA, misL, spi4F, spi4H, spi4N, rRNA, and purR) of S. typhimurium was used as a standard to verify the confidence level of the DNA microarray chip. In conclusion, using PCR amplification to increase the confidence level of the microarray hybridization data was successful. JF - Molecular and Cellular Probes AU - Courtney, Shannon AU - Mossoba, Miriam E AU - Hammack, Thomas S AU - Keys, Christine AU - Al-Khaldi, Sufian F AD - HFS-517, Division of Microbiological Studies, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA, sufian.alkhaldi@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 163 EP - 171 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 20 IS - 3-4 SN - 0890-8508, 0890-8508 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - DNA microarray KW - Salmonella typhimurium KW - PCR KW - Virulence KW - Genomes KW - rRNA KW - Data processing KW - DNA probes KW - Polymerase chain reaction KW - DNA microarrays KW - Oligonucleotides KW - W 30910:Imaging KW - A 01116:Bacteria KW - N 14810:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19969191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Using+PCR+amplification+to+increase+the+confidence+level+of+Salmonella+typhimurium+DNA+microarray+chip+hybridization&rft.au=Courtney%2C+Shannon%3BMossoba%2C+Miriam+E%3BHammack%2C+Thomas+S%3BKeys%2C+Christine%3BAl-Khaldi%2C+Sufian+F&rft.aulast=Courtney&rft.aufirst=Shannon&rft.date=2006-06-01&rft.volume=20&rft.issue=3-4&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2005.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; rRNA; Data processing; DNA probes; Polymerase chain reaction; Oligonucleotides; DNA microarrays; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.mcp.2005.12.001 ER - TY - JOUR T1 - In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques AN - 19964604; 6999323 AB - Immunodeficiency after peripheral blood progenitor cell (PBPC) transplantation may be influenced by graft composition, underlying disease, and/or pre-treatment. These factors are difficult to study independently in humans. Ex vivo culture and genetic manipulation of PBPC grafts may also affect immune reconstitution, with relevance to gene therapy applications. We directly compared the effects of three clinically relevant autologous graft compositions on immune reconstitution after myeloblative total body irradiation in rhesus macaques, the first time these studies have been performed in a large animal model with direct clinical relevance. Animals received CD34 super(+) cell dose-matched grafts of either peripheral blood mononuclear cells, purified CD34 super(+) PBPCs, or purified CD34 super(+) PBPCs expanded in vitro and retrovirally transduced. We evaluated the reconstitution of T, B, natural killer, dendritic cells, and monocytes in blood and lymph nodes for up to 1 year post-transplantation. Animals receiving selected-transduced CD34 super(+) cells had the fastest recovery of T-cell numbers, along with the highest T-cell-receptor gene rearrangement excision circles levels, the fewest proliferating Ki-67 super(+) T-cells in the blood, and the best-preserved thymic architecture. Selected-transduced CD34 super(+) cells may therefore repopulate the thymus more efficiently and promote a higher output of naive T-cells. These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation. JF - Stem Cells AU - Lore, Karin AU - Seggewiss, Ruth AU - Guenaga, FJavier AU - Pittaluga, Stefania AU - Donahue, Robert E AU - Krouse, Allen AU - Metzger, Mark E AU - Koup, Richard A AU - Reilly, Cavan AU - Douek, Daniel C AU - Dunbar, Cynthia E AD - Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland. Hematopathology Section, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Division of Biostatistics, University of Minnesota, Twin Cities, Minnesota Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1539 EP - 1548 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Gene therapy KW - Thymus KW - Animal models KW - Immunodeficiency KW - Natural killer cells KW - Cell culture KW - CD34 antigen KW - Clinical trials KW - Lymph nodes KW - Immune reconstitution KW - Dendritic cells KW - Stem cells KW - Peripheral blood mononuclear cells KW - Radiation KW - gene rearrangement KW - Lymphocytes T KW - Hemopoiesis KW - Macaca mulatta KW - Monocytes KW - W 30905:Medical Applications KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=In+Vitro+Culture+During+Retroviral+Transduction+Improves+Thymic+Repopulation+and+Output+After+Total+Body+Irradiation+and+Autologous+Peripheral+Blood+Progenitor+Cell+Transplantation+in+Rhesus+Macaques&rft.au=Lore%2C+Karin%3BSeggewiss%2C+Ruth%3BGuenaga%2C+FJavier%3BPittaluga%2C+Stefania%3BDonahue%2C+Robert+E%3BKrouse%2C+Allen%3BMetzger%2C+Mark+E%3BKoup%2C+Richard+A%3BReilly%2C+Cavan%3BDouek%2C+Daniel+C%3BDunbar%2C+Cynthia+E&rft.aulast=Lore&rft.aufirst=Karin&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Thymus; Natural killer cells; Immunodeficiency; Animal models; CD34 antigen; Cell culture; Clinical trials; Lymph nodes; Immune reconstitution; Dendritic cells; Peripheral blood mononuclear cells; Stem cells; Radiation; gene rearrangement; Lymphocytes T; Hemopoiesis; Monocytes; Macaca mulatta ER - TY - JOUR T1 - Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building AN - 19960506; 6878486 AB - We investigated the associations of fungal and endotoxin levels in office dust with respiratory health in 888 (67% participation) occupants of a water-damaged building. We analyzed floor and chair dusts from 338 workstations for culturable fungi and endotoxin. Based on averages, we ranked each floor of the building as low, medium, or high for occupants' exposure to each of these agents. Multivariate logistic regression models for building-related symptoms included this ranking of fungi and endotoxin, age, gender, race, smoking status, and duration of occupancy. Using floor dust measures, we found significantly increased odds for lower respiratory symptoms [wheeze, chest tightness, attacks of shortness of breath, and attacks of cough: odds ratios (OR) = 1.7 (95% confidence interval (CI): 1.02-2.77) to 2.4 (95% CI: 1.29-4.59)], throat irritation [OR = 1.7, (95% CI: 1.06-2.82)], and rash/itchy skin [OR = 3.0, (95% CI: 1.47-6.19)] in the highest fungal exposure group compared to the lowest, with generally linear exposure-response relationships. Nonlinear relationships were observed for many of these symptoms and endotoxin in floor dust. Interaction models showed that endotoxin modified effects of fungi on respiratory symptoms. Our findings of exposure interactions and exposure-response relationships of fungal and endotoxin with increased risk of building-related symptoms contribute to an understanding of the role of microbial agents in building-related asthma and respiratory and systemic symptoms. JF - Indoor Air AU - Park, J-H AU - Cox-Ganser, J AU - Rao, C AU - Kreiss, K AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, Morgantown WV, USA, gzp8@cdc.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 192 EP - 203 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 16 IS - 3 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Health & Safety Science Abstracts KW - Endotoxins KW - Age KW - Pharynx KW - Airborne microorganisms KW - Respiratory diseases KW - Chest KW - Dust KW - Models KW - Smoking KW - Exanthema KW - Dose-response effects KW - Regression analysis KW - Occupational exposure KW - Races KW - Skin KW - Fungi KW - Cough KW - Asthma KW - Irritation KW - Gender KW - Indoor environments KW - H 3000:Environment and Ecology KW - P 0000:AIR POLLUTION KW - A 01490:Miscellaneous KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Fungal+and+endotoxin+measurements+in+dust+associated+with+respiratory+symptoms+in+a+water-damaged+office+building&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J%3BRao%2C+C%3BKreiss%2C+K&rft.aulast=Park&rft.aufirst=J-H&rft.date=2006-06-01&rft.volume=16&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2005.00415.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - SuppNotes - Figures, 4; tables, 4. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Age; Skin; Pharynx; Fungi; Asthma; Cough; Chest; Dust; Irritation; Models; Exanthema; Smoking; Dose-response effects; Regression analysis; Races; Gender; Airborne microorganisms; Respiratory diseases; Indoor environments; Occupational exposure DO - http://dx.doi.org/10.1111/j.1600-0668.2005.00415.x ER - TY - JOUR T1 - Novel Conjugate of Moxifloxacin and Carboxymethylated Glucan with Enhanced Activity against Mycobacterium tuberculosis AN - 19959928; 6944482 AB - Mycobacterium tuberculosis is an intracellular pathogen that persists within macrophages of the human host. One approach to improving the treatment of tuberculosis (TB) is the targeted delivery of antibiotics to macrophages using ligands to macrophage receptors. The moxifloxacin-conjugated dansylated carboxymethylglucan (M-DCMG) conjugate was prepared by chemically linking dansylcadaverine (D) and moxifloxacin (M) to carboxymethylglucan (CMG), a known ligand of macrophage scavenger receptors. The targeted delivery to macrophages and the antituberculosis activity of the conjugate M-DCMG were studied in vitro and in vivo. Using fluorescence microscopy, fluorimetry, and the J774 macrophage cell line, M-DCMG was shown to accumulate in macrophages through scavenger receptors in a dose-dependent (1 to 50 mu g/ml) manner. After intravenous administration of M-DCMG into C57BL/6 mice, the fluorescent conjugate was concentrated in the macrophages of the lungs and spleen. Analyses of the pharmacokinetics of the conjugate demonstrated that M-DCMG was more rapidly accumulated and more persistent in tissues than free moxifloxacin. Importantly, therapeutic studies of mycobacterial growth in C57BL/6 mice showed that the M-DCMG conjugate was significantly more potent than free moxifloxacin. JF - Antimicrobial Agents & Chemotherapy AU - Schwartz, Y S AU - Dushkin, MI AU - Vavilin, V A AU - Melnikova, E V AU - Khoschenko, OM AU - Kozlov, V A AU - Agafonov, A P AU - Alekseev, A Y AU - Rassadkin, Y AU - Shestapalov, A M AU - Azaev AU - Saraev, D V AU - Filimonov, P N AU - Kurunov, Y AU - Svistelnik, A V AU - Krasnov, V A AU - Pathak, A AU - Derrick, S C AU - Reynolds, R C AU - Morris, S AU - Blinov, V M AD - Institute of Clinical Immunology SD RAMS, Novosibirsk, Russia. State Research Center of Virology and Biotechnology Vector, Russian Ministry of Public Health, Koltsovo, Novosibirsk Region, Russia. Novosibirsk Institute of Tuberculosis, Russian Ministry of Public Health, Novosibirsk, Russia. Southern Research Institute, Birmingham, Alabama. FDA/CBER, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1982 EP - 1988 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Intravenous administration KW - Fluorescence KW - Spleen KW - Antibiotics KW - Pathogens KW - Pharmacokinetics KW - Antimicrobial agents KW - Lung KW - Moxifloxacin KW - Microscopy KW - Tuberculosis KW - scavenger receptors KW - glucans KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Novel+Conjugate+of+Moxifloxacin+and+Carboxymethylated+Glucan+with+Enhanced+Activity+against+Mycobacterium+tuberculosis&rft.au=Schwartz%2C+Y+S%3BDushkin%2C+MI%3BVavilin%2C+V+A%3BMelnikova%2C+E+V%3BKhoschenko%2C+OM%3BKozlov%2C+V+A%3BAgafonov%2C+A+P%3BAlekseev%2C+A+Y%3BRassadkin%2C+Y%3BShestapalov%2C+A+M%3BAzaev%3BSaraev%2C+D+V%3BFilimonov%2C+P+N%3BKurunov%2C+Y%3BSvistelnik%2C+A+V%3BKrasnov%2C+V+A%3BPathak%2C+A%3BDerrick%2C+S+C%3BReynolds%2C+R+C%3BMorris%2C+S%3BBlinov%2C+V+M&rft.aulast=Schwartz&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=50&rft.issue=6&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Intravenous administration; Fluorescence; Spleen; Antibiotics; Pathogens; Pharmacokinetics; Antimicrobial agents; Moxifloxacin; Lung; Microscopy; Tuberculosis; glucans; scavenger receptors; Mycobacterium tuberculosis ER - TY - JOUR T1 - Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts AN - 19776359; 6950190 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies were performed to screen for potential toxicities (intrinsic and immunotoxicities). All treatment-related toxicities identified in these repeated-dose toxicology studies have been confined primarily to the sites of injection and seem to be the result of both the delivery method (as they are seen in both control and treated animals) and the intended immune response to the vaccine (as they occur with greater frequency and severity in treated animals). Reactogenicity at the site of injection is generally seen to be reversible as the frequency and severity diminished between doses and between the immediate and recovery termination time points. This observation also correlated with the biodistribution data reported in the companion article (Sheets et al., 2006), in which DNA plasmid vaccine was shown to remain at the site of injection, rather than biodistributing widely, and to clear over time. The results of these safety studies have been submitted to the Food and Drug Administration to support the safety of initiating clinical studies with these and related DNA plasmid vaccines. Thus far, standard repeated-dose toxicology studies have not identified any target organs for toxicity (other than the injection site) for our DNA plasmid vaccines at doses up to 8 mg per immunization, regardless of disease indication (i.e., expressed gene-insert) and despite differences (strengths) in the promoters used to drive this expression. As clinical data accumulate with these products, it will be possible to retrospectively compare the safety profiles of the products in the clinic to the results of the repeated-dose toxicology studies, in order to determine the utility of such toxicology studies for signaling potential immunotoxicities or intrinsic toxicities from DNA vaccines. These data build on the biodistribution studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Andrews, Charla AU - Bailer, Robert AU - Rathmann, John AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 620 EP - 630 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Toxicology Abstracts KW - vaccines KW - Data processing KW - severe acute respiratory syndrome KW - Severe acute respiratory syndrome KW - Ebola virus KW - Toxicity KW - Plasmids KW - Immunization KW - immunization KW - infectious diseases KW - Promoters KW - Immunotoxicity KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Cytokines KW - Immune response KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - Signal transduction KW - V 22360:AIDS and HIV KW - H 14000:Toxicology KW - X 24221:Toxicity testing KW - N 14810:Methods KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicological+Safety+Evaluation+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar+Despite+Differing+Plasmid+Backbones+or+Gene-Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BAndrews%2C+Charla%3BBailer%2C+Robert%3BRathmann%2C+John%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Toxicity; Plasmids; Immunization; Promoters; Immunotoxicity; DNA vaccines; Infectious diseases; Cytokines; Vaccines; Immune response; Signal transduction; Immunoglobulins; immunization; infectious diseases; vaccines; severe acute respiratory syndrome; DNA; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - Purchaser strategies to influence quality of care: from rhetoric to global applications AN - 19553417; 8747484 AB - The potential of purchasers to influence the quality and safety of care has captured the attention of health sector leaders worldwide. Quality based purchasing explicitly seeks to hold providers accountable for the quality and safety of care. Three strategies are available to purchasers: (1) selective contracting based on quality; (2) payment differentials based on quality; and (3) sponsorship of comparative provider report cards. Examples are given to illustrate each of the three strategies. Governments, employers, social insurance funds, community based insurance organizations, health plans, donors, and other buyers of health services are encouraged to explore and debate these purchaser strategies within the context of an overarching national or local quality framework. Public and private funders of operations research are encouraged to support and disseminate evaluations of purchaser efforts to improve quality. This paper is designed to highlight and frame purchasers' strategies explicitly crafted to enhance the quality and safety of care. The ultimate aim is to encourage thoughtful discussion about whether or not one or more purchaser strategy might support a particular country's goals to improve care. Experiences from both developed and developing countries are included to facilitate the exchange of ideas and provide the broadest of perspectives. JF - Quality & Safety in Health Care AU - McNamara, P AD - Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA, pmcnamar@ahrq.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 VL - 15 IS - 3 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - community involvement KW - Insurance KW - funds KW - Health care KW - operations research KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19553417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Purchaser+strategies+to+influence+quality+of+care%3A+from+rhetoric+to+global+applications&rft.au=McNamara%2C+P&rft.aulast=McNamara&rft.aufirst=P&rft.date=2006-06-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Insurance; operations research; funds; Health care; community involvement; Developing countries ER - TY - JOUR T1 - Histopathological Effects in Fish Exposed to the Toxins from Karlodinium micrum AN - 19462459; 7026224 AB - Karlodinium micrum (family Dinophyceae) produces toxic compounds (KmTx's) that are associated with fish kills. For zebrafish Danio rerio larvae (24 h old) exposed to either KmTx 1 or KmTx 2, mortality (100% in 24 h) was observed at toxin concentrations of 1 mu g/mL or more, whereas no mortality occurred after 24 h at concentrations of 0.5 mu g/mL or less. Zebrafish and sheepshead minnow Cyprinodon variegatus juveniles (60-90 d old) exposed to KmTx 2 were more sensitive to the toxin's effects than larvae were; mortalities in the juveniles began at 0.1-0.5 mu g/mL. In whole, sectioned juvenile zebrafish, gills were the primary site showing injury by light microscopy. Histology of gills in both species treated with 0.5 mu g KmTx 2/mL (100% mortality in 1 h) showed epithelial necrosis and shortening or loss of secondary lamellae. Histology of zebrafish gills treated with 0.05 and 0.1 mu g/mL (0-44% mortality in 4 h) showed clubbing and bridging between secondary lamellae within 4 h of exposure. Sheepshead minnow exposed to 0.1 mu g/mL showed similar gill pathology but no mortality after 6 h. Sheepshead minnow exposed to KmTx 2 at 0.5 mu g/mL or more all died in less than 1 h. Transmission electron microscopy of gills of moribund zebrafish exposed to 0.1 mu g/mL revealed extensive cellular hypertrophy and lysis of epithelial and chloride cells. Because concentrations of KmTx 1 and KmTx 2 range from 0.1 to 0.8 mu g/mL in filtered water samples from K. micrum-associated fish kills, these results suggest that the concentrations of KmTx 1 and KmTx 2 found during fish kills are acutely toxic to fish and that gills are a primary target. JF - Journal of Aquatic Animal Health AU - Deeds, Jonathan R AU - Reimschuessel, Renate AU - Place, Allen R AD - University of Maryland Biotechnology Institute, Center of Marine Biotechnology, 701 East Pratt Street, Suite 236, Baltimore, Maryland 21202, USA; and U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Seafood, 8301 Muirkirk Road, Laurel, Maryland 20708, USA Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 136 EP - 148 PB - American Fisheries Society, 5410 Grosvenor Ln. Ste. 110 Bethesda MD 20814-2199 USA VL - 18 IS - 2 SN - 0899-7659, 0899-7659 KW - Sheepshead minnow KW - Zebra danio KW - Zebra fish KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Aquatic animals KW - Injuries KW - Toxicants KW - Pathology KW - Transmission electron microscopy KW - Lamellae KW - Phytoplankton KW - Histopathology KW - Chloride KW - Dinophyceae KW - Freshwater KW - Freshwater fish KW - Toxicity tests KW - Fish larvae KW - Fish kill KW - Necrosis KW - Gills KW - Mortality KW - Biological poisons KW - Toxins KW - Danio rerio KW - Hypertrophy KW - Microscopy KW - Karlodinium micrum KW - Cyprinodon variegatus KW - Mortality causes KW - Q1 08346:Physiology, biochemistry, biophysics KW - X 24370:Natural Toxins KW - K 03039:Algae KW - Q5 08504:Effects on organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19462459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aquatic+Animal+Health&rft.atitle=Histopathological+Effects+in+Fish+Exposed+to+the+Toxins+from+Karlodinium+micrum&rft.au=Deeds%2C+Jonathan+R%3BReimschuessel%2C+Renate%3BPlace%2C+Allen+R&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2006-06-01&rft.volume=18&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aquatic+Animal+Health&rft.issn=08997659&rft_id=info:doi/10.1577%2FH05-027.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Fish kill; Pathology; Toxicants; Biological poisons; Histopathology; Phytoplankton; Freshwater fish; Fish larvae; Toxicity tests; Gills; Mortality causes; Aquatic animals; Mortality; Necrosis; Hypertrophy; Injuries; Transmission electron microscopy; Microscopy; Lamellae; Chloride; Toxins; Danio rerio; Dinophyceae; Karlodinium micrum; Cyprinodon variegatus; Freshwater DO - http://dx.doi.org/10.1577/H05-027.1 ER - TY - JOUR T1 - Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity AN - 19455424; 6996344 AB - Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced .OH and [Formula: see text] radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF- Kappa B and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor- alpha . These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumor xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumor cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo. JF - Journal of Biological Chemistry AU - Ding, Min AU - Feng, Rentian AU - Wang, Shiow Y AU - Bowman, Linda AU - Lu, Yongju AU - Qian, Yong AU - Castranova, Vincent AU - Jiang, Bing-Hua AU - Shi, Xianglin AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, the Fruit Laboratory, Beltsville Agricultural Research Center, U. S. Department of Agriculture, Beltsville, Maryland 20705, and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia 26505 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17359 EP - 17368 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 25 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Anthocyanins KW - Cyclooxygenase-2 KW - Transformation KW - Fruits KW - MAP kinase KW - Vegetables KW - Skin KW - Lung carcinoma KW - Food KW - natural products KW - Tumors KW - Tumor cells KW - TPA KW - NF- Kappa B protein KW - Metastases KW - Tumor cell lines KW - U.V. radiation KW - Carcinogenesis KW - Tumor necrosis factor- alpha KW - Cell migration KW - Xenografts KW - Radicals KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19455424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cyanidin-3-glucoside%2C+a+Natural+Product+Derived+from+Blackberry%2C+Exhibits+Chemopreventive+and+Chemotherapeutic+Activity&rft.au=Ding%2C+Min%3BFeng%2C+Rentian%3BWang%2C+Shiow+Y%3BBowman%2C+Linda%3BLu%2C+Yongju%3BQian%2C+Yong%3BCastranova%2C+Vincent%3BJiang%2C+Bing-Hua%3BShi%2C+Xianglin&rft.aulast=Ding&rft.aufirst=Min&rft.date=2006-06-01&rft.volume=281&rft.issue=25&rft.spage=17359&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Cyclooxygenase-2; Anthocyanins; Fruits; Vegetables; MAP kinase; Skin; Lung carcinoma; Food; natural products; Tumors; Tumor cells; TPA; NF- Kappa B protein; Metastases; Tumor cell lines; U.V. radiation; Carcinogenesis; Xenografts; Cell migration; Tumor necrosis factor- alpha; Radicals ER - TY - BOOK T1 - Modeling of hand-arm vibration AN - 19395381; 7157617 AB - The aerospace and automotive industries are facing a significant risk for cumulative trauma disorders from high-repetition, long-duration tasks. Additional risk factors such as shocks, vibrations and sustained uncomfortable postures oftentimes contribute to musculoskeletal, neurological injuries associated with the hand-arm system. The power tools used for the operation reduce the comfort and working efficiency of the operators, thus lowering their health and safety and the quality of operation. This paper investigates the fastening operation on the assembly line of a major aerospace company for quantifying hand-arm vibrations with the objective of developing a dynamic model of the hand-arm system. The model will be used to ascertain the effect of the various risk factors on the quality of the operation. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Joshi, A AU - Guttenberg, R AU - Leu, M C AU - Murray, S L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - cumulative trauma disorders KW - Injuries KW - Vibration KW - Automotive industry KW - Occupational exposure KW - musculoskeletal system KW - posture KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Joshi%2C+A%3BGuttenberg%2C+R%3BLeu%2C+M+C%3BMurray%2C+S+L&rft.aulast=Joshi&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Modeling+of+hand-arm+vibration&rft.title=Modeling+of+hand-arm+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Design of a test bench to evaluate the vibration emission values of jackleg rock drills AN - 19395351; 7157603 AB - Jackleg rock drills are widely used in the mining industry and are known to generate high levels of hand-arm vibration which contribute to the development of the hand-arm vibration syndrome for exposed miners. To reduce the vibration levels, a prototype of an antivibration handle was developed as part of a previous study. To provide some bench marking for this handle prototype and to follow the evolution of its performance over time, a test bench was developed to characterize the vibration emission values of jackleg drills under controlled operating conditions. As the current ISO 8662 series of standards could not apply directly to this type of tool, there was a need to design and validate a test bench to evaluate the vibration emission values of jackleg drills, while taking into account the conditions specific to the operation of this type of tool. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Marcotte, P AU - Ouellette, S AU - Boutin, J AU - Boileaul, P-E AU - Leblanc, G AU - Oddo, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Emissions KW - Emission standards KW - hand-arm vibration syndrome KW - Working conditions KW - Ergonomics KW - Occupational exposure KW - Design KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Marcotte%2C+P%3BOuellette%2C+S%3BBoutin%2C+J%3BBoileaul%2C+P-E%3BLeblanc%2C+G%3BOddo%2C+R&rft.aulast=Marcotte&rft.aufirst=P&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Design+of+a+test+bench+to+evaluate+the+vibration+emission+values+of+jackleg+rock+drills&rft.title=Design+of+a+test+bench+to+evaluate+the+vibration+emission+values+of+jackleg+rock+drills&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Characteristics of whole-body vibration frequencies and low back pain in urban taxi drivers AN - 19395300; 7157591 AB - Occupational exposures to whole-body vibration (WBV) at different frequency domains may differentially affect human comfort and the musculoskeletal system. Under this presumption, a frequency-based weighting scheme has been adapted in many widely accepted standards for WBV measurement. However, there is very little human data showing a direct link between WBV frequency and musculoskeletal disorders. We conducted an epidemiologic study to examine the association between WBV frequency and prevalence of low back pain (LBP) and to identify determinants of specific frequencies associated with LBP in urban taxi drivers. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Chen, J-C AU - Chang, W-R AU - Hatfield, B H AU - Christiani, D C Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - low back pain KW - musculoskeletal system KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chen%2C+J-C%3BChang%2C+W-R%3BHatfield%2C+B+H%3BChristiani%2C+D+C&rft.aulast=Chen&rft.aufirst=J-C&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Characteristics+of+whole-body+vibration+frequencies+and+low+back+pain+in+urban+taxi+drivers&rft.title=Characteristics+of+whole-body+vibration+frequencies+and+low+back+pain+in+urban+taxi+drivers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Pneumatic active suspension design for heavy vehicle seats and operator ride comfort AN - 19395273; 7157571 AB - Handling of heavy vehicles such as tractors, trucks and buses require a large roll stiffness which causes large high accelerations at the seat level during impacts. To provide comfort and minimize the energy transfer from the chassis and the seat a pneumatic active seat suspension is proposed. An active seat suspension design and control algorithm under development at the University of Illinois at Chicago, UIC, is being developed and tested. Preliminary results are presented in this paper. The design of a passive suspension typically consists of optimizing the value of two parameters: the stiffness and the damping of the suspension. The general dynamic performance of the suspension is limited to the conditions under which these parameters were obtained. A change in the input conditions might lead to poor suspension and an amplification of the vibration transmitted to the body. The focus of this paper is a robust, semi-active suspension system with a variable controlled damping and using the body response an index measure to minimize the acceleration at the interface of the seat and operator. A summary of existing suspensions, such as MR and ER fluids, and spring loaded and dual valve shock absorbent will be discussed to highlight the need of a semi-active pneumatic suspension system design. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Valero, B AU - Amirouche, F AU - Mayton, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Illinois, Chicago KW - buses KW - USA, Illinois KW - Vibration KW - Materials handling KW - Trucks KW - Design KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Valero%2C+B%3BAmirouche%2C+F%3BMayton%2C+A&rft.aulast=Valero&rft.aufirst=B&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Pneumatic+active+suspension+design+for+heavy+vehicle+seats+and+operator+ride+comfort&rft.title=Pneumatic+active+suspension+design+for+heavy+vehicle+seats+and+operator+ride+comfort&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of whole-body vibration comfort AN - 19395243; 7157557 AB - The purpose of using experimental subjective and/or perception methods is: (a) to understand human subjective impressions of the physical characteristics of vibration; (b) to determine the relationship between the subjective perception of some aspect of the vibration and an evaluation index of the physical vibration characteristics; and (c) the establishment of target values for design of vibration environments in terms of human sensation of vibration characteristics. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Maeda, S AU - Mansfield, N J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Maeda%2C+S%3BMansfield%2C+N+J&rft.aulast=Maeda&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+whole-body+vibration+comfort&rft.title=Evaluation+of+whole-body+vibration+comfort&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of the capability of seat suspension to reduce the operator exposure to vibration in Track Type Tractors AN - 19394053; 7157608 AB - The European Union (EU) completed a new directive 2002/44/EC called the Physical Agents Directive (PAD) that establishes action and limit values for hand-arm and whole body vibrations. The directive specifies that: "...workers shall not be exposed above the exposure `limit value'." and "...once the exposure action values ... are exceeded, the employer shall establish and implement a programme of technical and/or organisational measures intended to reduce to a minimum exposure to mechanical vibration and the attendant risks... " The PAD limit value is effective for new machines starting July 6, 2007 and for used machines by at least July 6, 2010. These requirements apply to the users of machines, but machine manufacturers will be challenged to provide machines and information to help the users comply with the directive. Caterpillar manufactures machines with the goal of enabling our customers to comply with all regulations dealing with health and safety. Caterpillar designs all of our machines to provide a safe, comfortable and productive work environment. This study was to determine if seat suspensions could provide a reduction in the vibration environment experienced by operators of Caterpillar mid sized (<50,000KG) Track Type Tractors. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Contratto AU - Brodersen, T AU - Marshall, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - tractors KW - Health & Safety Science Abstracts KW - European Union KW - Vibration KW - Occupational exposure KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Contratto%3BBrodersen%2C+T%3BMarshall%2C+D&rft.aulast=Contratto&rft.aufirst=&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+the+capability+of+seat+suspension+to+reduce+the+operator+exposure+to+vibration+in+Track+Type+Tractors&rft.title=Evaluation+of+the+capability+of+seat+suspension+to+reduce+the+operator+exposure+to+vibration+in+Track+Type+Tractors&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Influence of back support conditions on the absorbed power of seated occupants under horizontal vibration AN - 19394028; 7157594 AB - The absorbed power (P sub(Abs)) has been suggested as a better measure of human responses to whole-body vibration, since it relates to the cumulative energy dissipated by the body exposed over a given duration. Moreover, unlike the other measures, the P sub(Abs) can adequately account for the intensity of exposure. Although, the vast majority of off-road vehicles impose considerably severe vibration along the horizontal axes, the vast majority of studies on biodynamic response characterization consider only vertical vibration. Only a few studies have reported P sub(Abs) responses of the seated human body exposed to horizontal vibration and the major contributing factors. This study aims to characterize the P sub(Abs) responses of seated human subjects to horizontal (uncoupled x- and y-axis) vibration as functions of the vibration intensity, subject mass, seat height and the, type of back support. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Mandapuram, S AU - Rakheja, S AU - Ma, S AU - Boileau, P-E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mandapuram%2C+S%3BRakheja%2C+S%3BMa%2C+S%3BBoileau%2C+P-E&rft.aulast=Mandapuram&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Influence+of+back+support+conditions+on+the+absorbed+power+of+seated+occupants+under+horizontal+vibration&rft.title=Influence+of+back+support+conditions+on+the+absorbed+power+of+seated+occupants+under+horizontal+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Comfort evaluation for mine shuttle car seat designs AN - 19394007; 7157567 AB - Industrial equipment exposes individuals to whole-body vibration (WBV) and mechanical shock. This exposure can negatively impact their health, safety, comfort, and working efficiency and performance. Accordingly, proper seat design is an important consideration in reducing the adverse effects of WBV exposure to vehicle operators. Since the human body is sensitive to low frequency WBV, ride quality is a basic and important element of good seat design. When designing a suitable seat, it is essential to understand vibration exposure environment of workers and how well they can tolerate this environment This is particularly true in the mining industry. Mayton et al. reported on a low-coal shuttle car seat design that underwent limited, yet successful underground mine trials. Building on this work, a follow-up study compared NIOSH and existing seat designs on low- and mid-coal seam shuttle cars. The NIOSH seat designs included viscoelastic foam, which has properties similar to those found in a mechanical spring/damper suspension system. The seats also included an adjustable lumbar support and a fore-aft seat adjustment. The NIOSH seat designs contrast with the existing seat design, which have little or no lumbar support and include inexpensive foam padding of the type commonly used in furniture. This paper will focus on the seat designs for the mid-coal seam shuttle car and compare subjective comfort data collected from five vehicle operators with ISO 2631 - based reduced comfort boundary (RCB) analysis of recorded vibration levels. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Mayton, A AU - Jobes, C AU - Kittusamy, N K AU - Amirouche, F Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - safety engineering KW - Vibration KW - Mines KW - USA, Connecticut, Hartford Basin, Newark Supergroup, Shuttle KW - Protective equipment KW - Occupational exposure KW - Side effects KW - Design KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mayton%2C+A%3BJobes%2C+C%3BKittusamy%2C+N+K%3BAmirouche%2C+F&rft.aulast=Mayton&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Comfort+evaluation+for+mine+shuttle+car+seat+designs&rft.title=Comfort+evaluation+for+mine+shuttle+car+seat+designs&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Training Simulators Extend Laboratory Testing Techniques for WBV Analysis AN - 19392903; 7157613 AB - Human testing has always been a needed way to provide information on the effects of vehicle vibration, however, the manner of testing has not reflected the real situations of driver's hands on a steering wheel and a seat with back support and driving tasks. The typical system have used a standard sinusoidal excitation rather than the typical types of road - truck excitations The new truck driver training simulators provide the combination of road roughness, speed effects, cab environment and individual tasks. The system has a full six axis simulation potential. The simulators have the protection of the individual by a combination of two ways for the individual to stop the motion as well as an operator with visual capability who can stop the testing. The closed simulator, has the potential for providing motion during v the operation. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wasserman, J AU - Mullinix, L AU - Khanal, S AU - Hinton, G AU - Wasserman, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Laboratory testing KW - Training KW - driving ability KW - Vibration KW - Simulation KW - Trucks KW - Highways KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wasserman%2C+J%3BMullinix%2C+L%3BKhanal%2C+S%3BHinton%2C+G%3BWasserman%2C+D&rft.aulast=Wasserman&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Training+Simulators+Extend+Laboratory+Testing+Techniques+for+WBV+Analysis&rft.title=Training+Simulators+Extend+Laboratory+Testing+Techniques+for+WBV+Analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration time and rest time during sinusoidal vibration experiments: Do these factors affect comfort ratings? AN - 19392868; 7157623 AB - Industrial exposure to whole-body vibration is associated with injury and discomfort. Certain industries, notably mining, construction, and forestry, involve complex 6 degrees of freedom vibration. Laboratory-based studies of vibration are essential for controlled and systematic evaluation of the human responses to vibration. The purpose of this pilot study was to evaluate whether the duration of the vibration exposure, and rest between vibrations, significantly influence the subjective ratings of comfort during laboratory-based studies of vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dickey, J P AU - Oliver, M L AU - Shee, NKL AU - Boileau, P-E AU - Eger, T R AU - Trick, L M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Vibration KW - Occupational exposure KW - Working conditions KW - Forestry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dickey%2C+J+P%3BOliver%2C+M+L%3BShee%2C+NKL%3BBoileau%2C+P-E%3BEger%2C+T+R%3BTrick%2C+L+M&rft.aulast=Dickey&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+time+and+rest+time+during+sinusoidal+vibration+experiments%3A+Do+these+factors+affect+comfort+ratings%3F&rft.title=Vibration+time+and+rest+time+during+sinusoidal+vibration+experiments%3A+Do+these+factors+affect+comfort+ratings%3F&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Head-trunk motion increase with arm-rest controls AN - 19392864; 7157610 AB - Heavy equipment manufacturers have made a long-term commitment to minimize operator vibration exposure for comfort, performance, and health reasons. Domestic and international guidelines/standards and EC laws dictate exposure limits based on measurement of vibration at the interface between the seat and the operator's buttocks using seat-pad accelerometry. This is historically based on the assumption that the only major source of vibration is transmitted through the seat pan. However, vibration may also be imparted to the head and neck via the steering wheel and/or arm-rest controls and a relatively rigid upper body. Unfortunately, little is known regarding the influence of arm position on head and neck motion. The purpose of this study was to investigate relative head and trunk motions during riding simulations of large construction equipment, using three different arm control options. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Rahmatalla, S AU - Contratto, M AU - Xia, T AU - Frey-Law, L AU - Kopp, G AU - Grosland, N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Vibration KW - Simulation KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BRahmatalla%2C+S%3BContratto%2C+M%3BXia%2C+T%3BFrey-Law%2C+L%3BKopp%2C+G%3BGrosland%2C+N&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Head-trunk+motion+increase+with+arm-rest+controls&rft.title=Head-trunk+motion+increase+with+arm-rest+controls&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Clinical assessment and characteristics of men and women exposed to high level of hand-arm vibration AN - 19392839; 7157619 AB - While the neurological and vascular aspects of Hand-Arm Vibration Syndrome (HAVS) has been generally accepted as a medical condition, the medical criteria and the clinical findings used to establish the diagnosis has been more difficult to bring to consensus. The criteria was first quantified by the Taylor-Palmear scale. This criteria was subsequently modified in 1986 at the 1 Stockholm Workshop to included more acceptance for the neurological effects that characterized the predominate findings in some workers. The relationship between hand-arm vibration and Carpal Tunnel Syndrome was defined in NIOSH 97-141. The purpose of this study is to look at recent case studies of men and women exposed to jobs with high levels of hand-arm vibration with extensive clinical testing for both the neurological and vascular components of HAVS as well as other associated upper extremity conditions such as Carpal Tunnel Syndrome. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jetzer, T AU - Ketcham, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Sweden, Stockholm KW - Vibration KW - carpal tunnel syndrome KW - overuse injuries KW - males KW - hand-arm vibration syndrome KW - Females KW - musculoskeletal system KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jetzer%2C+T%3BKetcham%2C+D&rft.aulast=Jetzer&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Clinical+assessment+and+characteristics+of+men+and+women+exposed+to+high+level+of+hand-arm+vibration&rft.title=Clinical+assessment+and+characteristics+of+men+and+women+exposed+to+high+level+of+hand-arm+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A portable measurement system for the assessment of time weighted and impulsive exposures to whole body vibration AN - 19392823; 7157593 AB - Bus drivers represent a large segment of the US transportation industry and research has shown an association between exposure to Whole Body Vibration (WBV) and the high rates of low back disorders. Impulsive WBV exposures have been recognized as a risk factor for low back injury and new guidelines exist for their measurement and assessment (ISO 2631, Part 5). Methods to accurately and better characterize the impulsiveness of WBV along with the temporal patterns of the exposures are needed. The development of a hardware and software system to measure continuous TWA and raw, impulsive WBV exposures and the design of a subsequent study are presented. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Johnson, P W AU - Ploger, J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Computer programs KW - Transportation KW - Injuries KW - Vibration KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+P+W%3BPloger%2C+J&rft.aulast=Johnson&rft.aufirst=P&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+portable+measurement+system+for+the+assessment+of+time+weighted+and+impulsive+exposures+to+whole+body+vibration&rft.title=A+portable+measurement+system+for+the+assessment+of+time+weighted+and+impulsive+exposures+to+whole+body+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A novel theory: Ellipse of grip force AN - 19392816; 7157615 AB - Hand forces are important factors for risk assessment of hand-arm vibration syndrome (HAVS) Grip force is one of the most important force components in the operation of powered hand tools. A considerable number of studies on grip force have been reported. It is well known that the grip force applied on a cylindrical handle is not uniformly distributed on each axis across the center of the handle cross-section. Therefore, maximum and minimum orientations of grip force exist around the handle. Such orientations have not been clearly identified. In a recently proposed international standard (ISO/CD 15230, 2005), it is stated that "the direction of the main gripping force is generally parallel to the z-axis defined in ISO 8727." This assertion is questionable, and further examinations are required. The objective of this study was to establish a fundamental theory on the distribution of the grip force around cylindrical handles. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dong, R G AU - Welcome, DE AU - Warren, C AU - Dong, CL AU - McDowell, T W AU - Wu, J Z Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Vibration KW - hand-arm vibration syndrome KW - hand tools KW - Occupational exposure KW - International standardization KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BWarren%2C+C%3BDong%2C+CL%3BMcDowell%2C+T+W%3BWu%2C+J+Z&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+novel+theory%3A+Ellipse+of+grip+force&rft.title=A+novel+theory%3A+Ellipse+of+grip+force&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Upper body joint coordination under vibration AN - 19392795; 7157583 AB - Whole body vibration is known to affect movement accuracy, however little is known about changes in the organization of movement and movement strategies used to limit the influences of perturbations. The specific aim of this work is to analyze the motion and coordination of upper body segments of seated operators performing reaching tasks under whole-body sinusoidal vibration exposure and simulated vehicle ride motion. The long-term objective is to model reach coordination and predict the dynamic behavior of the upper body motion under vehicle vibration exposure. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Lee, J AU - Yoon, J-H AU - Rider, K AU - Martin, B J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lee%2C+J%3BYoon%2C+J-H%3BRider%2C+K%3BMartin%2C+B+J&rft.aulast=Lee&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Upper+body+joint+coordination+under+vibration&rft.title=Upper+body+joint+coordination+under+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Arm and shoulder muscle activity are greater with steering wheel vs. seat mounted controls AN - 19392768; 7157611 AB - Chronic whole-body vibration exposure, as expected in large construction and mining vehicles, has been associated with neck and back pain and injury. While work has been done towards gaining a better understanding of the relationship between vibration and shock and muscle activity of the back musculature, relatively little information regarding the activity of neck, shoulder and upper arm muscles is known. Today's equipment designs must conform to domestic and international standards, however these standards do not specifically address the vibration exposure in the head and upper quarter. Further it is not well known how the control configuration within a vehicle (e.g. steering wheel versus arm controls) influences muscle voluntary and reflex activity levels. Greater muscle activity may lead to greater muscle fatigue -which in turn may be associated with greater risk of injury. Thus, muscle contractions needed to maintain static postures as well as those resulting reflexively should be considered during an analysis of seating position. Unfortunately, little is known regarding the influence of arm position on head and neck muscle function. The purpose of this study was to investigate the relative muscle activities of 5 neck, shoulder, and upper arm muscles during riding simulations of large construction equipment, using three different arm control options. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Law, L F AU - Rahmatalla, S AU - Wilder, D AU - Grosland, N AU - Xia, T AU - Hunstad, T AU - Contratto, M AU - Kopp, G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Vibration KW - Muscles KW - Simulation KW - Mining KW - back pain KW - Construction industry KW - fatigue KW - International standardization KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Law%2C+L+F%3BRahmatalla%2C+S%3BWilder%2C+D%3BGrosland%2C+N%3BXia%2C+T%3BHunstad%2C+T%3BContratto%2C+M%3BKopp%2C+G&rft.aulast=Law&rft.aufirst=L&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Arm+and+shoulder+muscle+activity+are+greater+with+steering+wheel+vs.+seat+mounted+controls&rft.title=Arm+and+shoulder+muscle+activity+are+greater+with+steering+wheel+vs.+seat+mounted+controls&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Simulation of human motion, muscle forces and lumbar spine stresses due to whole-body-vibration: Application of the dynamic human model casimir for the development of commercial vehicles and passenger cars AN - 19392753; 7157575 AB - In the development of commercial vehicles as well as of passenger cars, the effects of vehicle vibrations on operating safety, health and comfort can only be predicted by numerical simulation when appropriate occupant models are available. Such models must be based on human anatomy and have dynamic properties of real humans in order to achieve realistic results. Since human dynamic behavior depend on posture and percentile, the occupant model needs to be adjustable to these parameters with respect to geometry and dynamic properties. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Pankoke, S AU - Siefert, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Vibration KW - Muscles KW - Simulation KW - Stress KW - Occupational exposure KW - Anatomy KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pankoke%2C+S%3BSiefert%2C+A&rft.aulast=Pankoke&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Simulation+of+human+motion%2C+muscle+forces+and+lumbar+spine+stresses+due+to+whole-body-vibration%3A+Application+of+the+dynamic+human+model+casimir+for+the+development+of+commercial+vehicles+and+passenger+cars&rft.title=Simulation+of+human+motion%2C+muscle+forces+and+lumbar+spine+stresses+due+to+whole-body-vibration%3A+Application+of+the+dynamic+human+model+casimir+for+the+development+of+commercial+vehicles+and+passenger+cars&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Establishment of an experimental system for measring biodynamic response of hand-arm AN - 19392749; 7157612 AB - This paper addresses establishment of an experimental system for measuring biodynamic response (BR) of hand-arm system at the NIIH in Japan. BR measurement system at the NIIH is nearly equivalent to NIOSH installed system. The feasibility of the system is examined through the apparent mass (AM) measurement of the empty handle and a set of calibration masses. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Hosoya, N AU - Maeda, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Feasibility studies KW - Hand-arm vibration syndrome KW - Conferences KW - Vibration KW - Japan KW - Working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hosoya%2C+N%3BMaeda%2C+S&rft.aulast=Hosoya&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Establishment+of+an+experimental+system+for+measring+biodynamic+response+of+hand-arm&rft.title=Establishment+of+an+experimental+system+for+measring+biodynamic+response+of+hand-arm&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Measurement and evaluation of vibration exposure for locomotive crew members AN - 19392743; 7157606 AB - The vibration and impact environment for crew members on locomotives has been investigated in a series of studies conducted by Exponent Failure Analysis Associates (Exponent) beginning in 1990. Locomotive cab vibration and impact levels were measured on a variety of locomotive models operating over many different track sections across the Union Pacific, Burlington Northern Santa Fe, CSX, Norfolk Southern, and CONRAIL systems. The comfort and health implications of exposure to the measured locomotive vibration levels were evaluated by comparison with the human vibration exposure boundaries given in the International Standards Organization (ISO) standard 2631-1:1997, the British Standard 6841:1987, European Union (EU) Directive 2002/44/EC, measurements made by Exponent on various commercial and recreational vehicles, and vibration exposure measurement data found in the literature. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Larson, R AU - Raasch, C AU - Pierce, J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - European Union KW - locomotives KW - USA, Vermont, Burlington KW - Vibration KW - IN, Pacific KW - Crew safety KW - ANE, British Isles, England, Norfolk KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Larson%2C+R%3BRaasch%2C+C%3BPierce%2C+J&rft.aulast=Larson&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Measurement+and+evaluation+of+vibration+exposure+for+locomotive+crew+members&rft.title=Measurement+and+evaluation+of+vibration+exposure+for+locomotive+crew+members&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration spectral class characterization of long haul dump mining vehicles and seat performance evaluation AN - 19392712; 7157560 AB - Long-haul dump (LHD) vehicles used in underground mining are known to expose workers to important levels of whole-body vibration. These vehicles are generally designed without suspension and may be categorized as small or large LHDs depending on whether their respective load capacities are lower or larger than 3.5 cubic yards. While the majority of older vehicles are equipped with a rigid or unsuspended seat, more recent LHDs often incorporate a suspension seat. The objective of this study was to define the vibration spectral characteristics of most commonly encountered large and small LHD vehicles operating in mining operations. This was done in an effort to categorize the vehicles in terms of vibration spectral classes to be reproduced on a laboratory whole-body vibration simulator to assess the vibration attenuation performance of a typical LHD suspension seat. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Boileau, P-E AU - Boutin, J AU - Eger, T AU - Smets, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Mining KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Boileau%2C+P-E%3BBoutin%2C+J%3BEger%2C+T%3BSmets%2C+M&rft.aulast=Boileau&rft.aufirst=P-E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+spectral+class+characterization+of+long+haul+dump+mining+vehicles+and+seat+performance+evaluation&rft.title=Vibration+spectral+class+characterization+of+long+haul+dump+mining+vehicles+and+seat+performance+evaluation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Whole-body vibration exposure and driver posture evaluation during the operation of LHD vehicles in underground mining AN - 19392711; 7157605 AB - Load-haul dump vehicles (LHDs) are used to move waste rock and ore in underground mining operations. The LHD is designed for bi-directional operation and the driver sits sideways to the direction of travel. LHD operators have higher reports of low back pain and neck discomfort than other mobile equipment operators who do not sit sideways in the vehicle, but are exposed to whole-body vibration (WBV). Exposure to WBV is linked with reports of lower-back pain, neck problems and spinal degeneration. Static sitting postures, sitting with the neck and back twisted, and sitting with the back in an unsupported posture are also linked with an increased risk of developing back pain. The objective of this study was to determine typical vibration exposure levels and driving postures for LHD operators. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Eger, T AU - Stevenson, J AU - Grenier, S AU - Boileau, P-E AU - Smets, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - low back pain KW - Mining KW - Ergonomics KW - Working conditions KW - Occupational exposure KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Eger%2C+T%3BStevenson%2C+J%3BGrenier%2C+S%3BBoileau%2C+P-E%3BSmets%2C+M&rft.aulast=Eger&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Whole-body+vibration+exposure+and+driver+posture+evaluation+during+the+operation+of+LHD+vehicles+in+underground+mining&rft.title=Whole-body+vibration+exposure+and+driver+posture+evaluation+during+the+operation+of+LHD+vehicles+in+underground+mining&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Effects of short-term exposure to whole-body vibration on wakefulness AN - 19392707; 7157584 AB - Whole-body vibration occurs when the body is supported on a surface which is vibrating. Occupational exposures to whole-body vibration mainly occurs in the transportation industry, but also in association with other industrial process. Epidemiological studies have frequently indicated an elevated health risk for the spine in workers exposed to whole-body vibration. With regarding to train or bus operators, a fall of drivers' wakefulness level because of fatigue is often pointed out. This decrease in wakefulness results in an increase of the occurrence of accidents. However, a study of how whole-body vibration affects people's level of wakefulness has not been done. To test the hypothesis that exposure to whole-body vibration has a certain effects on level of wakefulness, the change of a subjective wakefulness level and changes of electroencephalogram (EEG) were observed under experimental exposure to short-term whole-body vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Satou, Y AU - Ando, H AU - Ishitake, T Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Accidents KW - spine KW - Transportation KW - Conferences KW - Vibration KW - Occupational exposure KW - fatigue KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Satou%2C+Y%3BAndo%2C+H%3BIshitake%2C+T&rft.aulast=Satou&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Effects+of+short-term+exposure+to+whole-body+vibration+on+wakefulness&rft.title=Effects+of+short-term+exposure+to+whole-body+vibration+on+wakefulness&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Computational simulation of a pneumatic chipping hammer AN - 19392704; 7157602 AB - Occupational exposure to hand transmitted vibration (HTV) arises from the hand held powered tools extensively used in the mining and construction industry such as rock drills, chipping hammers, chain saws etc. Regular exposure to HTV is the major cause of a range of permanent injuries to human hands and arms which are commonly referred to as hand-arm vibration syndrome (HAVS). In addition to this, the percussive tools generate overall sound power levels in excess of 1 10dBA in most cases. Such a high sound power level greatly exceeds the maximum permissible exposure limit (PEL) of organizations such as National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA). Long term occupational exposure to this noise has been diagnosed as the main reason for permanent hearing loss in the operators. It is therefore important to develop an understanding of the mechanisms which lead to these high vibration and sound levels and in order to do this a detailed computational model of a pneumatic chipping hammer has been made. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kadam, R AU - Schwartz, K AU - Johnson, M AU - Burdisso, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Federal regulations KW - Injuries KW - Vibration KW - Simulation KW - safety regulations KW - hand-arm vibration syndrome KW - Hearing loss KW - Occupational exposure KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kadam%2C+R%3BSchwartz%2C+K%3BJohnson%2C+M%3BBurdisso%2C+R&rft.aulast=Kadam&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Computational+simulation+of+a+pneumatic+chipping+hammer&rft.title=Computational+simulation+of+a+pneumatic+chipping+hammer&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Comparison of anti-vibration interventions for use with fastening tools in metal AN - 19392683; 7157599 AB - Tool manufacturers continue to incorporate new designs to the internal mechanism of tools in order to decrease the vibration that is delivered to the hand during operation. Modification of some tools to minimize tool vibration is not easily resolved through internal tool design. For this reason, vibration damping materials applied between the tool and the hand are a simple alternative. The damping materials may be applied to the area of the tool directly contacted by the operator or in a glove containing a vibration absorbing pad. These interventions are developed specifically to damp vibration but are not necessarily produced and tested under the same work conditions that a company may expose their workers. Therefore, it is important to test the value of the proposed interventions for the specific applications. This study evaluates the effectiveness of anti-vibration interventions currently in use at a local manufacturing company. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dale, A M AU - Standeven, J AU - Evanoff, B Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Manufacturing industry KW - Vibration KW - gloves KW - Occupational exposure KW - Hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dale%2C+A+M%3BStandeven%2C+J%3BEvanoff%2C+B&rft.aulast=Dale&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Comparison+of+anti-vibration+interventions+for+use+with+fastening+tools+in+metal&rft.title=Comparison+of+anti-vibration+interventions+for+use+with+fastening+tools+in+metal&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Response to sudden load by patients with back pain AN - 19392663; 7157582 AB - As mechanical shock and vibration environments evolve, it is important to understand their potential effect on human operators. Human beings are sophisticated mechanisms comprised not only of passive components with mass, damping, and stiffness characteristics, but also of components that can actively affect apparent mass, stiffness, and damping. Because the lumbar spine can exhibit local, short-column buckling, stability of the human trunk depends on the responsiveness of the neuromuscular control system. We have been evaluating the ability of patients with back pain to respond to a series of sudden loads. We believe the results have implications for isolation design and standards development. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Xia, T AU - Gudavalli, R AU - Owens, E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Conferences KW - Vibration KW - back pain KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BXia%2C+T%3BGudavalli%2C+R%3BOwens%2C+E&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Response+to+sudden+load+by+patients+with+back+pain&rft.title=Response+to+sudden+load+by+patients+with+back+pain&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Using an air bladder seat shock isolation system to protect military vehicle occupants from mine blasts AN - 19392660; 7157559 AB - Landmines are a great threat to military vehicles and their occupants. Mine blasts can completely destroy vehicles and kill all the occupants or disable the vehicle and leave the occupants severely injured. Injuries sustained during a landmine blast come from fragmentation that enters the vehicle through a hull breach, hot gasses expanding through the vehicle, or shock created from the extreme pressure of the blast (Lafrance, L.P. 1998). Mitigating the high acceleration experienced by the occupants during survivable mine blasts is the focus of the research being addressed in this paper. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Reynolds, D D AU - Liu, Q AU - Deeb, T Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - landmines KW - Injuries KW - Vibration KW - Military KW - Explosions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reynolds%2C+D+D%3BLiu%2C+Q%3BDeeb%2C+T&rft.aulast=Reynolds&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Using+an+air+bladder+seat+shock+isolation+system+to+protect+military+vehicle+occupants+from+mine+blasts&rft.title=Using+an+air+bladder+seat+shock+isolation+system+to+protect+military+vehicle+occupants+from+mine+blasts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Neuromotor habituation as a mechanism for vibration induced low back pain AN - 19392653; 7157570 AB - Occupational exposure to whole body vibration has long been associated with increased incidence of low back pain and low back injuries. A number of studies have investigated transmissibility of seat pan vibration. While transmissibility has been well researched, the mechanism by which vibration may induce injury has not been thoroughly studied. Winter et al. identified increased reflex response delay after vibration exposure and speculated that muscular fatigue may be the cause of this increase. However, a mechanism has yet to be demonstrated completely. A potential mechanism that may explain the increased risk is neuromotor habituation. Muscle spindle organs have been shown in the extremities to be sensitive to muscle and tendon vibration. Rapid length changes in muscle have been shown to result in kinesthetic illusions as the regular firing of the muscle spindles is interpreted as muscle lengthening. These illusions have also been demonstrated in the paraspinal musculature. With removal of vibration, research in the extremities has demonstrated increased positioning errors, probably due to neuromotor habituation. In this research, it has been hypothesized that neuromotor habituation after exposure to occupational vibration will increase positioning errors. It is further hypothesized that these errors can be shown to be linked to increased reflex response time. Such increased reflex response time could, in turn, decrease spinal stability and increase low back injury risk. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilson, SE AU - Li, L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Conferences KW - Vibration KW - Muscles KW - low back pain KW - extremities KW - Organs KW - fatigue KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilson%2C+SE%3BLi%2C+L&rft.aulast=Wilson&rft.aufirst=SE&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Neuromotor+habituation+as+a+mechanism+for+vibration+induced+low+back+pain&rft.title=Neuromotor+habituation+as+a+mechanism+for+vibration+induced+low+back+pain&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Seated human response to simple and complex impacts AN - 19392633; 7157581 AB - The human lumbar spine is inherently an unstable structure and requires sophisticated neuromuscular control to maintain its stability and for performing physical tasks. As a consequence, it is important to understand the potential health effects on human operators of mechanical stimuli such as shock and vibration. Impact applied to a vehicle operator combines the risk of sudden, unexpected load with the mechanical stress of the seated posture. Because many work environments contain the potential for multiple, unexpected impacts, it is important to understand how the trunk muscles respond to complex conditions. We believe the results have implications for isolation design and standards development. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Xia, T AU - Ankrum, J AU - Spratt, K Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Vibration KW - Muscles KW - Stress KW - Ergonomics KW - Working conditions KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BXia%2C+T%3BAnkrum%2C+J%3BSpratt%2C+K&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seated+human+response+to+simple+and+complex+impacts&rft.title=Seated+human+response+to+simple+and+complex+impacts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Perception thresholds for lateral vibration at the hand, seat, and foot AN - 19392627; 7157569 AB - Discomfort, annoyance, or interference with activities due to exposure to vibration is only expected if the vibration exceeds the threshold for the perception of vibration. When there is more than one vibration input to the body (e.g. at the hands, seat and feet), the sensation is first experienced at the location with greatest sensitivity. Knowledge of differences in the thresholds of perception for vibration at the hand, seat, and feet should assist the identification of sources of discomfort caused by vibration. Perception thresholds for vibration have been determined in several studies, but only a few studies have investigated perception thresholds in the horizontal direction for hand-transmitted vibration or whole-body vibration, and there has been little consideration of perception thresholds for the foot resting on a vibrating surface. This study determines absolute thresholds for the perception of sinusoidal lateral vibration, examining the effect of vibration frequency (8 to 315 Hz for the hand and foot; 2 to 315 Hz for the seat) and the effect of input location (the hand, the seat and the foot). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Morioka, M AU - Griffin, MJ Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Perception KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Morioka%2C+M%3BGriffin%2C+MJ&rft.aulast=Morioka&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Perception+thresholds+for+lateral+vibration+at+the+hand%2C+seat%2C+and+foot&rft.title=Perception+thresholds+for+lateral+vibration+at+the+hand%2C+seat%2C+and+foot&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Challenges and uncertainties in designing field studies to measure hand vibration AN - 19392604; 7157564 AB - We encountered several areas of methodologic uncertainty during development of a data collection method for use with vibrating hand tools in metal assembly. A local manufacturer sought our assistance designing a data collection method for evaluating and predicting risks of upper extremity disorders associated with use of vibrating hand tools. Current methods of vibration measurement are described in ISO 5349 [2]. However, the complexity of measuring vibration along with other exposures such as force and posture has limited the number of workplace-based studies of upper extremity disorders that have included direct measurements of vibration. Data from this preliminary study was used to look at two issues: a comparison of vibration values between production and non-production workers when performing the same task, and a comparison of worker ratings of vibration comfort to direct measurement of tool vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dale, A M AU - Standeven, J AU - Evanoff, B Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Data collection KW - Conferences KW - Vibration KW - musculoskeletal system KW - hand tools KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dale%2C+A+M%3BStandeven%2C+J%3BEvanoff%2C+B&rft.aulast=Dale&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Challenges+and+uncertainties+in+designing+field+studies+to+measure+hand+vibration&rft.title=Challenges+and+uncertainties+in+designing+field+studies+to+measure+hand+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Railroad locomotive whole-body vibration study: Vibration, shocks and seat ergonomics AN - 19392514; 7157618 AB - North American railroad locomotive operators (engineers and conductors) are exposed to multi-axis vibration and shocks. A recent epidemiological survey showed a prevalence of serious type of neck and lower back disorders nearly double that of a control group. Ergonomic working conditions are important co-factors in a vibration and shock exposure risk assessment The goal of this study is to illustrate typical work stations (cabs and seats) in US/Canadian type locomotives and assess shock related exposure risk by calculations of the new proposed shock risk indicators according to the new ISO 2631-5 (2004). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Johanning, E AU - Fischer, S AU - Christ, E AU - Gores, B AU - Luhrman, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - locomotives KW - Vibration KW - Railroads KW - working conditions KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johanning%2C+E%3BFischer%2C+S%3BChrist%2C+E%3BGores%2C+B%3BLuhrman%2C+R&rft.aulast=Johanning&rft.aufirst=E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Railroad+locomotive+whole-body+vibration+study%3A+Vibration%2C+shocks+and+seat+ergonomics&rft.title=Railroad+locomotive+whole-body+vibration+study%3A+Vibration%2C+shocks+and+seat+ergonomics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Instrumented handles for studying hand-transmitted vibration exposure AN - 19392473; 7157614 AB - Instrumented handles or dynamometers are widely used to measure hand forces and/or the biodynamic response of hand-arm system. To study hand-transmitted vibration exposure, six generations of instrument handles were constructed or initially developed by researchers in ECTB/HELD/NIOSH. This presentation provided a summary of these handles. Their basic characteristics, limitations, and usefulness are described, which may help their appropriate applications and further improvements. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Welcome, DE AU - Dong, R G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Occupational exposure KW - Working conditions KW - Hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Welcome%2C+DE%3BDong%2C+R+G&rft.aulast=Welcome&rft.aufirst=DE&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Instrumented+handles+for+studying+hand-transmitted+vibration+exposure&rft.title=Instrumented+handles+for+studying+hand-transmitted+vibration+exposure&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Investigation into the uncertainty in measurements and evaluation of hand-transmitted vibration AN - 19392449; 7157592 AB - Accurate measurement and evaluation of hand-transmitted vibration from a power tool is an important issue for tool manufacturers, because they are obliged to develop low-hazard power tools for workers. The International Standard ISO 5349 dictates a systematic procedure for the measurement and evaluation of hand-transmitted vibration. However, the uncertainty in this measurement is too large for manufacturers to apply such data to the design and modification of power tools. There can be several sources of this uncertainty in such measurements; e.g., operator-dependent, power tool-dependent, and operational conditions For a manufacturer to characterize the exposure of a power tool's use to a given level of vibration, the relationship between these uncertainty factors and the measured vibration must be elucidated. In this study, we investigated the effect of several factors on the uncertainty in measurements. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jang, H-K AU - Song, C-M AU - Hong, S-I AU - Choi, S-H Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jang%2C+H-K%3BSong%2C+C-M%3BHong%2C+S-I%3BChoi%2C+S-H&rft.aulast=Jang&rft.aufirst=H-K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Investigation+into+the+uncertainty+in+measurements+and+evaluation+of+hand-transmitted+vibration&rft.title=Investigation+into+the+uncertainty+in+measurements+and+evaluation+of+hand-transmitted+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Device for measuring daylong vibration exposure and grip force levels for during hand-tool use AN - 19392392; 7157563 AB - Over the past two decades, there have been significant reductions in industrial exposures to hand-arm vibration, especially when specific tools and work processes have been redesigned to incorporate anti-vibration and ergonomic principles. Nevertheless, Hand-Arm Vibration Syndrome (HAVS) remains a significant occupational health problem as disease symptoms continue to occur even when vibration exposure levels believed to incur low risks have been reached. This inconsistency may be related to the methodology that is typically used to estimate workday vibration exposure levels, involving laboratory and/or very short duration field measurements coupled with estimates of overall eight-hour tool operation times determined from brief observations of tool tasks and/or self-reported surveys. One solution is to use small, commercially-available, personal vibration dosimeters to calculate, record, and display long-duration vector sums and energy equivalents of vibration. However, since these devices are attached to the worker and require tool-mounted accelerometers, they are incompatible with the worker performing normal duties involving putting down or changing tools. In addition, these commercial systems do not allow for the characterization of the transmission of vibration to the hand such as monitoring the mechanical coupling between the hand and the tool handle (e.g., grip forces). O'Boyle and Griffin showed that variations in applied force can alter vibration transmission characteristics by 50% or more indicating that the measurement of grip force is essential for modeling vibration transmissibility and vibration exposures. In summary, a need exists for the development of a method and device that will more accurately characterize workday-long vibration exposures. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Peterson AU - Brammer, A J AU - Cherniack, M G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - Ergonomics KW - working conditions KW - Hand tools KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Peterson%3BBrammer%2C+A+J%3BCherniack%2C+M+G&rft.aulast=Peterson&rft.aufirst=&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Device+for+measuring+daylong+vibration+exposure+and+grip+force+levels+for+during+hand-tool+use&rft.title=Device+for+measuring+daylong+vibration+exposure+and+grip+force+levels+for+during+hand-tool+use&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Time-frequency analysis of hand-transmitted vibration of impact tools using analytic wavelet transform AN - 19392361; 7157561 AB - Prolonged, extensive exposure to hand-transmitted vibration could cause a series of vibration-induced disorders in the vascular, sensorineural, and musculoskeletal structures of the human hand-arm system, which have been collectively called hand-arm vibration syndrome (HAVS). To assess the risk of HAVS the international standard ISO 5349-1 (2001) recommends using the root-mean-square (rms) acceleration of the measured vibration with a frequency weighting. While a few epidemiological studies have reported results consistent with the predictions made according to the recommendation, many other studies have reported results with large discrepancies. This may be partially attributed to the time-averaging effect involved in calculation of the frequency components, especially for impact type tools. Because the spectral characteristics of impact tools change dramatically with time, a time-frequency (T-F) analysis can provide better characterizations of such highly transient vibrations. The analytic wavelet transform (AWT) is an ideal T-F analysis tool because it possesses the advantages of both the Fourier transform and the wavelet transform. The objective of this study was to explore the application of the AWT method for characterizing the impact tool vibrations and assessing their exposure risk. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kim, J AU - Welcome, DE AU - Dong, R G AU - Song, W J AU - Hayden, C Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - musculoskeletal system KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kim%2C+J%3BWelcome%2C+DE%3BDong%2C+R+G%3BSong%2C+W+J%3BHayden%2C+C&rft.aulast=Kim&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Time-frequency+analysis+of+hand-transmitted+vibration+of+impact+tools+using+analytic+wavelet+transform&rft.title=Time-frequency+analysis+of+hand-transmitted+vibration+of+impact+tools+using+analytic+wavelet+transform&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Revision of ANSI S3.34 (2.70-2006) - guide for the measurement and evaluation of human exposure to vibration transmitted to the hand AN - 19391811; 7157588 AB - Intense vibration can be transmitted to the hands and arms of workers who use hand-held percussive or vibrating devices, tools, and work pieces. Continued habitual exposure to vibration directed to the hands can cause patterns of various symptoms associated with hand-arm vibration syndrome (HVAS). The International Organization for Standardization (ISO) first published ISO 5349 in 1986. This standard specified methods for measuring and evaluating vibration directed into the hands from hand-held vibrating devices, tools, and work pieces. The American National Standards Institute (ANSI) published ANSI S3.34 the same year. This standard was modeled after ISO 5349-1986 and specified methods for assessing exposure to hand-arm vibration. The Parliament of the European Union has issued the European Union Human Vibration Directive-2002/44/EC, which specifies vibration daily exposure action values (DEAV) of 2.5 m/s super(2) and daily exposure limit values (DELV) of 5.0 m/s super(2). These values have generally been accepted by medical experts, scientists, and engineers in governmental agencies, research institutions, and industry in the USA and other countries. When they are achieved, they will reduce the potential for the development of symptoms related to HAVS among workers exposed to hand-arm vibration. Significant improvements in measurement and analysis instrumentation, miniature and subminiature accelerometers, and medical diagnostic and assessment protocols have being introduced since 1986 when ANSI S3.34 was first published. In response to these improvements and the introduction of the EU Human Vibration Directive, ANSI Working Group S2.39 developed the revision to ANSI S3.34, which has now been published as ANSI S2.70-2006. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Reynolds, D D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - European Union KW - Vibration KW - Standards KW - hand-arm vibration syndrome KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reynolds%2C+D+D&rft.aulast=Reynolds&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Revision+of+ANSI+S3.34+%282.70-2006%29+-+guide+for+the+measurement+and+evaluation+of+human+exposure+to+vibration+transmitted+to+the+hand&rft.title=Revision+of+ANSI+S3.34+%282.70-2006%29+-+guide+for+the+measurement+and+evaluation+of+human+exposure+to+vibration+transmitted+to+the+hand&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Shock and impact on North American locomotives evaluated with ISO 2631 Parts 1 and 5 AN - 19391784; 7157587 AB - The International Organization for Standardization (ISO) standard ISO 2631 provides three methods for evaluation of human exposure to vibrations that contain occasional shocks or impacts. Part 1 of the standard specifies the running r.m.s. or maximum transient vibration method (MTVV) and the fourth power vibration dose value (VDV). Part 5 of the standard provides a method of computing the stress in the lumbar spine for humans exposed to multiple shocks. Alem et al have reported application of these methods to data for tactical ground vehicles. This paper reports and compares VDV and spinal stress evaluations of more than 90 hours of vibration and shock measurements on North American locomotives engaged in through freight operations. The measurements evaluated in this paper were obtained for full crew shifts on 19 freight locomotive runs on mainline track in locations from New York to California. The shifts ranged in duration from 187 minutes to 497 minutes. The average speeds for the shifts were from 21.0 mph to 54.6 mph. All measurements were made on locomotives hauling freight trains in regular revenue service. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Cooperrider, N K AU - Gordon, J J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - locomotives KW - Conferences KW - Vibration KW - Stress KW - Standards KW - USA, California KW - USA, New York KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cooperrider%2C+N+K%3BGordon%2C+J+J&rft.aulast=Cooperrider&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Shock+and+impact+on+North+American+locomotives+evaluated+with+ISO+2631+Parts+1+and+5&rft.title=Shock+and+impact+on+North+American+locomotives+evaluated+with+ISO+2631+Parts+1+and+5&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Acute vibration exposure shifts the current perception threshold of A beta fibers in a rat tail model of vibration AN - 19391751; 7157580 AB - Occupational exposure to hand-arm vibration through the use of powered hand tools can result in reductions in tactile sensitivity, grip strength and manual dexterity. In fact, even acute exposures to vibration cause shifts in vibrotactile thresholds in exposed fingers. Although reductions in tactile sensitivity after acute vibration exposures are transient, cellular changes associated with this shift in sensitivity could lead to the more permanent reductions in tactile sensitivity that are a common symptom of hand-arm vibration syndrome (HAVS). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Perception KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Krajnak%2C+K+M&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Acute+vibration+exposure+shifts+the+current+perception+threshold+of+A+beta+fibers+in+a+rat+tail+model+of+vibration&rft.title=Acute+vibration+exposure+shifts+the+current+perception+threshold+of+A+beta+fibers+in+a+rat+tail+model+of+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Dynamic responses of a fingertip to vibration - 3D finite element analysis AN - 19391700; 7157573 AB - Although the exact mechanisms underlying vibration white finger (VWF) are not clear, it has been speculated that VWF is associated with variations of the blood flow patterns due to the physical damage and/or degeneration in neural and vascular tissue caused by vibration loading. Excessive dynamic deformation of the soft tissues in the fingertip under vibration loading is believed to induce multiple occupation-related hand/finger disorders. However, the in vivo distributions of the dynamic stress/strain of the tissues in the fingertip under vibration conditions have not been studied because they cannot be measured experimentally to date. The goal of this study is to analyze, theoretically, the location and frequency-dependent dynamic deformation of the soft tissue in the fingertip during vibration exposures. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wu, J Z AU - Krajnak, K AU - Welcome, DE AU - Dong, R G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Blood KW - Vibration KW - Stress KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wu%2C+J+Z%3BKrajnak%2C+K%3BWelcome%2C+DE%3BDong%2C+R+G&rft.aulast=Wu&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Dynamic+responses+of+a+fingertip+to+vibration+-+3D+finite+element+analysis&rft.title=Dynamic+responses+of+a+fingertip+to+vibration+-+3D+finite+element+analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Musculoskeletal symptoms among operators of heavy mobile equipment AN - 19390849; 7157609 AB - The purpose of this study was to assess the adequacy of the cab design and to determine the percentage of musculoskeletal symptoms among operators of mobile equipment used in mining and construction. A questionnaire was designed to assess demographics, work information, job history, and musculoskeletal symptoms in operators of heavy mobile equipment. Information concerning equipment included design of the seat/chair, levers, pedals, bothersome vibration, quality of ingress/egress from the equipment, proper preventative maintenance and repairs, and age of the equipment. The body regions that were evaluated included the neck, middle/upper back, low-back, shoulder/upper-arm, elbow/forearm, wrist/hand, hip, knee, and ankle/foot. Five hundred and eighty six operators completed the questionnaire. The results indicate that these workers are at risk for developing musculoskeletal disorders, and the need to quantify risk factors (i.e., whole-body vibration and static sitting postures). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kittusamy, N K Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Conferences KW - Vibration KW - musculoskeletal system KW - Maintenance KW - Occupational exposure KW - Working conditions KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kittusamy%2C+N+K&rft.aulast=Kittusamy&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Musculoskeletal+symptoms+among+operators+of+heavy+mobile+equipment&rft.title=Musculoskeletal+symptoms+among+operators+of+heavy+mobile+equipment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Health perception in workers exposed to hand-arm vibration: Prerequisite for putting in place an effective preventive program in the workplace AN - 19390800; 7157586 AB - Knowledge of risks from exposure to hand-arm vibrations is usually presented by clinicians and researchers from a medical and engineering point of view. There is a strong need to develop innovative health promotion programs for exposed workers. Risk perceptions by vibration exposed workers and HAVS (hand-arm vibration syndrome) affected workers are less well known. In 1983, Brubaker demonstrated that 75% of studied fellers thought that whitening of the fingers was part of the job and/or an unrelated nuisance, while only 25% believed it was a disease. Grounds also showed that even though there were a very high number of forestry workers with white fingers, none considered quitting because of their condition. It seems that many workers hesitate to declare the illness or believe they are less affected than they really are, perhaps from fear of losing their jobs and livelihood. Risk awareness, on the part of exposed workers and their employers, as well as knowledge and acceptance of available preventive solutions are necessary steps before installing adequate preventive measures, whether organizational, behavioral or environmental. Workers need to understand fully the hazards and risks in order to be able to make informed decisions under uncertain conditions. Prerequisites include the following: workers knowledge about the risk, their attitude towards it, which in turn, can be influenced by values, needs and interests. Also, knowledge and attitudes towards safety behaviour, organizational or environmental barriers must be taken into account. Our research focuses on these key elements, which help bridge the gap between health promotion research and practice. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Turcot, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - safety engineering KW - Perception KW - Vibration KW - hand-arm vibration syndrome KW - health promotion KW - Occupational exposure KW - Forestry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Turcot%2C+A&rft.aulast=Turcot&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+perception+in+workers+exposed+to+hand-arm+vibration%3A+Prerequisite+for+putting+in+place+an+effective+preventive+program+in+the+workplace&rft.title=Health+perception+in+workers+exposed+to+hand-arm+vibration%3A+Prerequisite+for+putting+in+place+an+effective+preventive+program+in+the+workplace&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The effects of vibration on psychophysical grip and push force-recall accuracy AN - 19390755; 7157566 AB - Workers using vibrating hand tools have the potential for developing health problems associated with repeated forceful actions and exposures to hand-transmitted vibration. Hand-arm vibration syndrome (HAVS) and other hand-arm system disorders have been associated with such exposures. To better assess health risks, comprehensive evaluations of these exposures must include quantitative assessments of hand-tool coupling forces; unfortunately, no standardized method for quantifying hand forces exists. Handle instrumentation may be ill-suited for some field environments. Psychophysical force-recall techniques may provide alternatives to handle instrumentation. A thorough understanding of the effects of vibration and other factors on force-recall accuracy and reliability is important before such methods are applied in risk assessments. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - McDowell, T W AU - Wiker, S F AU - Dong, R G AU - Welcome, DE Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McDowell%2C+T+W%3BWiker%2C+S+F%3BDong%2C+R+G%3BWelcome%2C+DE&rft.aulast=McDowell&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+effects+of+vibration+on+psychophysical+grip+and+push+force-recall+accuracy&rft.title=The+effects+of+vibration+on+psychophysical+grip+and+push+force-recall+accuracy&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Ride motion effects on the accuracy of rapid pointing tasks AN - 19390713; 7157565 AB - Reaching movements are planned and subsequently executed using visual and somatosensory feedbacks where absence of visual feedback is known to increase endpoint variability. Visual occlusion decreases the ability to make rapid online compensatory movements, which results in initial radial deviations that are highly correlated with radial dispersion at the target. Perturbations of rapid, visually-guided reaches are compensated on-line and result in endpoint dispersions poorly correlated with initial deviations, emphasizing the strong effect of visual feedback in temporally-constrained reaching tasks. In control conditions (no vibration), these uncompensated, rapid reaches serve as estimates of the individual's intended trajectory. When ride motion is present, trajectories of rapid, visually-occluded reaches provide a measure of the natural biodynamic response of the cantilevered spine-arm-hand linkage. These intended movement trajectories and the biodynamic response (vibration feedthrough) are used to predict the effect of ride motion on the performance of rapid reaching tasks. Goals of this study are to investigate the influences of vehicle motion on human reaching and pointing, and to reveal movement strategies used in visually-occluded reaching tasks. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Rider, KA AU - Martin, B J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - Materials handling KW - Working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rider%2C+KA%3BMartin%2C+B+J&rft.aulast=Rider&rft.aufirst=KA&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ride+motion+effects+on+the+accuracy+of+rapid+pointing+tasks&rft.title=Ride+motion+effects+on+the+accuracy+of+rapid+pointing+tasks&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A field study: Measurement and evaluation of whole body vibration for MH-60S pilots AN - 19390123; 7157616 AB - Pilots of the MH-60S helicopter are exposed to continuous whole body vibration (WBV). Pilot fatigue is a growing operational concern due to the increased frequency of extended durations of missions (6-8+hours) in support of Operations Iraqi Freedom and Enduring Freedom. Endurance aspects of the currently used rotary wing seating systems were not optimized for the longer missions and wide range of pilot anthropometric measurements, which is now typical of naval aviation. The current seating systems were designed primarily to meet crashworthiness requirements, not for the wide range of pilot anthropometry or to mitigate WBV. Albeit, an issue, pilot fatigue and reduced mission effectiveness are also critical concerns. Current Hazard Reports indicated that pain in pilots' legs and backs begin two to four hours into the flight and increase with time. Mission readiness also decreases with an increase in flight duration due to the constant distraction of pilots shifting in their seats while trying to get comfortable. Froom, et al reported a dose-response relationship between the length of military helicopter flights and back discomfort. He also concluded that this pain is typically dull, over the lower back, and its prevalence and intensity are dependent on the total flight hours of exposure. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Harrer, K AU - Estrada, N AU - Lavery, C AU - Nowell, J AU - Jennings, C AU - Yniguez, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - crashworthiness KW - Vibration KW - Dose-response effects KW - pain KW - Military KW - helicopters KW - fatigue KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Harrer%2C+K%3BEstrada%2C+N%3BLavery%2C+C%3BNowell%2C+J%3BJennings%2C+C%3BYniguez%2C+D&rft.aulast=Harrer&rft.aufirst=K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+field+study%3A+Measurement+and+evaluation+of+whole+body+vibration+for+MH-60S+pilots&rft.title=A+field+study%3A+Measurement+and+evaluation+of+whole+body+vibration+for+MH-60S+pilots&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Seat cushion and posture effects in military propeller aircraft vibration environments AN - 19390060; 7157598 AB - Annoyance, fatigue, and musculoskeletal pain have been reported during prolonged exposures to propulsion-generated vibration in military propeller aircraft. The objective of this study was to determine the vibration mitigation properties of selected seat cushions and the effects of occupant seating posture during exposure to higher frequency multi-axis vibration associated with military propeller aircraft. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Smith, S D AU - Smith, JA Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Aircraft KW - Vibration KW - pain KW - Military KW - Occupational exposure KW - musculoskeletal system KW - fatigue KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Smith%2C+S+D%3BSmith%2C+JA&rft.aulast=Smith&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seat+cushion+and+posture+effects+in+military+propeller+aircraft+vibration+environments&rft.title=Seat+cushion+and+posture+effects+in+military+propeller+aircraft+vibration+environments&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of scraper operator exposure to whole-body vibration in the construction industry: A task analysis AN - 19390038; 7157590 AB - Kittusamy (Kittusamy & Buchholz, 2004) state that there have been few studies conducted to assess exposure to whole-body vibration (WBV) in the construction industry. They suggest that there is very little reliable data from the construction industry that characterizes exposure levels to various hazards including WBV or the health outcomes from such exposure and that there is a need for more exposure data. In a recent exploratory study of heavy construction equipment Cann (Cann, Salmoni, Vi, & Eger, 2003) looked at vibration levels for 14 different types of construction equipment. Eight of the 14 pieces of equipment tested exposed operators to levels of WBV that exceeded the recommended limits for an 8-hour period when comparing the measured VDV to the ISO 2631-1 standards. The purpose of the present research was not only to test a larger number of scrapers but also to investigate scraper operator exposure to whole body vibration (WBV) separately for each task. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Gillin, E K AU - Cannl, A AU - Vi, P AU - Eger, T AU - Hunt, M AU - Salmoni, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Salmonidae KW - Construction industry KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gillin%2C+E+K%3BCannl%2C+A%3BVi%2C+P%3BEger%2C+T%3BHunt%2C+M%3BSalmoni%2C+A&rft.aulast=Gillin&rft.aufirst=E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+scraper+operator+exposure+to+whole-body+vibration+in+the+construction+industry%3A+A+task+analysis&rft.title=Evaluation+of+scraper+operator+exposure+to+whole-body+vibration+in+the+construction+industry%3A+A+task+analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Standard tests for suspended seats - can these contribute to protection against whole-body vibration? - commentary on historical development and current work in CEN/TC231/WG9 (Seating) AN - 19390013; 7157589 AB - Suspended seats perform two functions: Reduce effect of occasional large bumps; Reduce more continuous vibration at a lower level. The former needs high damping. The latter needs low damping. For most mobile work machines the inevitable compromise is generally better than a simple cushion seat, because that amplifies vibration at around 4 Hz which is a sensitive frequency for human vertical WBV. Why have standard tests for seat suspensions? Seat suspensions are non-linear so any measure of performance depends on operating conditions. For comparison these need to be defined. Seat manufacturers need benchmarks for product development; Machine makers choose dynamic characteristics appropriate to their products; Occupational health specialists wish to control operator exposure to Standard tests should be representative, repeatable and reproducible. These requirements are reviewed in relation to the history of seat test standards and the current position. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Stayner, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Vibration KW - Reviews KW - Standards KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stayner%2C+R&rft.aulast=Stayner&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Standard+tests+for+suspended+seats+-+can+these+contribute+to+protection+against+whole-body+vibration%3F+-+commentary+on+historical+development+and+current+work+in+CEN%2FTC231%2FWG9+%28Seating%29&rft.title=Standard+tests+for+suspended+seats+-+can+these+contribute+to+protection+against+whole-body+vibration%3F+-+commentary+on+historical+development+and+current+work+in+CEN%2FTC231%2FWG9+%28Seating%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Hand force-dependent modeling of the hand-arm under Z sub(H)-axis vibration AN - 19389969; 7157572 AB - A number of biodynamic models of the hand-arm system have evolved on the basis of measured driving-point mechanical impedance (DPMI) responses to facilitate analyses of the coupled hand-tool system. The parameter identifications in such models are based upon minimization of an error function of the model and the target impedance data, which may not yield a unique solution. Consequently, a number of model structures and parameter sets could be realized that would equally satisfy the target curve. Moreover, the vast majority of the reported models exhibit acute deficiencies due to excessive static deflections of model masses, presence of a low frequency mode and very light masses in the order of 1.2- 4.8 grams. The models also do not characterize the dependency of the biodynamic responses on many factors, namely the hand forces, hand-arm posture and vibration intensity. This study aims at development of a hand-arm biodynamic model with considerations of the hand forces, and both the DPMI and power absorption measures, to enhance the uniqueness of the model. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Aldien, Y AU - Rakheja, S AU - Marcotte, P AU - Boileau, P-E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Absorption KW - Occupational exposure KW - Working conditions KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Aldien%2C+Y%3BRakheja%2C+S%3BMarcotte%2C+P%3BBoileau%2C+P-E&rft.aulast=Aldien&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hand+force-dependent+modeling+of+the+hand-arm+under+Z+sub%28H%29-axis+vibration&rft.title=Hand+force-dependent+modeling+of+the+hand-arm+under+Z+sub%28H%29-axis+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A method of evaluating vehicle seat vibration with consideration of subjective judgment AN - 19389945; 7157568 AB - Vibration magnitude and frequency of the z-axis vehicle seat are time-variant, which are influenced by not only vehicle vibration characteristics themselves but also road surfaces, speeds and the human body. There is little in the current reporting about evaluating and analyzing automobile seat vibration that focuses on the time-variant. Yaguchi et al. has proposed a method to evaluate automobile seat vibration that is based on judgments using a subjective mental state. Their method focuses on the time-variant magnitude of the peak frequency on a power spectrum density. However, their method has no consideration of all the frequency contents of the discomfort, nor comparison between different peak frequency vibrations. Suzuki has emphasized that the vehicle vibration should be judged by a series of vibration stimuli to evaluate, because the vehicle vibration is time-variant, which isn't a matter of the relationship between a single vibration stimulus and a subjective response. He clarified that the human sensation to the vehicle vibration discomfort changes every moment showing the relationship between the frequency-weighted r.m.s. acceleration calculated every 5 seconds and the category judgment to vehicle vibration discomfort every 5 seconds. However, his study doesn't show what parameter connects to the subjective final judgment to vehicle vibration. Therefore, we applied the method similar to ISO 10056 considering the time-variant to the vehicle seat z-axis vibration evaluation. The new method for the vehicle seat vibration considering the time-variant was examined on the hypothesis that the final subjective evaluation must be conducted from the judgment summarizing a series of vibration stimuli. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Nakashima, Y AU - Maeda, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Motor vehicles KW - Highways KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Nakashima%2C+Y%3BMaeda%2C+S&rft.aulast=Nakashima&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+method+of+evaluating+vehicle+seat+vibration+with+consideration+of+subjective+judgment&rft.title=A+method+of+evaluating+vehicle+seat+vibration+with+consideration+of+subjective+judgment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Effects of repeated vibration exposures in muscle tissue AN - 19389668; 7157620 AB - Workers exposed to vibrating hand tools are at risk of developing symptoms such as cold-induced vasospasms, loss of tactile sensitivity, and loss of grip strength in the fingers and hands. These symptoms are known collectively as vibration white finger (VWF) or hand-arm vibration syndrome (HAVS). Symptoms of VWF or HAVS are in part due to repeated and prolonged peripheral vasoconstriction. The reduction in blood flow that occurs with vasoconstriction can result in oxygen deprivation (hypoxia) in soft tissues, such as nerves and muscle, and lead to functional and structural changes in these tissues. The present study examined muscle tissue to determine if vibration-induced changes in transcript levels and protein concentrations result in enhanced vasoconstriction and hypoxia. Manual dexterity was also assessed intermittently to determine if vibration-induced changes in cellular factors are accompanied by performance deficits. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wirth, O AU - Waugh, S AU - Johnson, C AU - Miller, G R AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Oxygen KW - Vibration KW - Hypoxia KW - Muscles KW - Proteins KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wirth%2C+O%3BWaugh%2C+S%3BJohnson%2C+C%3BMiller%2C+G+R%3BKrajnak%2C+K+M&rft.aulast=Wirth&rft.aufirst=O&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Effects+of+repeated+vibration+exposures+in+muscle+tissue&rft.title=Effects+of+repeated+vibration+exposures+in+muscle+tissue&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration emission measurement methods for Grinders AN - 19389623; 7157601 AB - ISO8662-4, "Hand-held portable power tools - Measurement of vibrations at the handle -Part 4: Grinders" is under revision. The new revision shall harmonize ISO 20643 "Mechanical vibration - Hand-held and hand-guided machinery - Principles for evaluation of vibration emission" which, among others, requires measurements in three directions and declared values related to the upper quartile of real-use vibration. To get the most suitable test method, a round robin test was made for evaluation of the two test methods proposed by the ad-hoc group working with this standard revision. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Persson, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Machinery KW - Emission measurements KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Persson%2C+M&rft.aulast=Persson&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+emission+measurement+methods+for+Grinders&rft.title=Vibration+emission+measurement+methods+for+Grinders&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A novel 3-D hand-arm vibration test system and its preliminary evaluations AN - 19389598; 7157596 AB - Vibration exposure at workplaces is generally multi-axial. The health effects of vibration exposure also likely depend on the vibration direction. Therefore, there is a wide interest in the simulation of multi-axial vibration in laboratory experiments. Advances in technology have led to the development of a new 3-D test system for studying hand-transmitted vibration exposure and health effects. The purposes of this paper are to introduce the system and to present the results of its preliminary evaluations. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dong, R G AU - Welcome, DE AU - McCormick, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Simulation KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BMcCormick%2C+R&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+novel+3-D+hand-arm+vibration+test+system+and+its+preliminary+evaluations&rft.title=A+novel+3-D+hand-arm+vibration+test+system+and+its+preliminary+evaluations&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A case study of whole-body vibration exposures associated with ordinary passenger and recreational vehicles AN - 19389579; 7157576 AB - Measurements and analyses were conducted of whole-body vibration aboard seven commercially available passenger and/or recreational vehicles: sedan; sport-utility vehicle (SUV); pickup truck; moving truck; motorcycle; all-terrain vehicle (ATV); and boat. The purpose of the testing was to measure and assess whole-body vibration exposure in a range of typical vehicle environments in order to gain understanding of typical exposure levels characteristic of activities of daily living. Vehicle models tested (and model year) were: Ford Taurus (1995); Jeep Cherokee Sport (2000); Toyota Tundra SR5 (2002); Ford F-350 (1997); Harley-Davidson Electra Glide Classic (2004); Yamaha Kodiak 400 4x4; and Steiger Craft Model 21 Montauk. All vehicles were tested with their standard factory-installed seats and were operated under a range of normal operating conditions and speeds typical of intended vehicle use. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Gibson, R G AU - Gibbons, J D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, New York, Long I., Montauk KW - Recreation areas KW - all-terrain vehicles KW - Electra KW - Vibration KW - Motor vehicles KW - boats KW - Trucks KW - Motorcycles KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gibson%2C+R+G%3BGibbons%2C+J+D&rft.aulast=Gibson&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+case+study+of+whole-body+vibration+exposures+associated+with+ordinary+passenger+and+recreational+vehicles&rft.title=A+case+study+of+whole-body+vibration+exposures+associated+with+ordinary+passenger+and+recreational+vehicles&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Handle design for optimal hand function AN - 19388820; 7157622 AB - Tubular Handles can negatively affect the contents of the carpal tunnel Years of injuries from grasping handles for tools and machines can cause carpal tunnel syndrome, tendonitis and wrist joint injuries. The can cause inability to use a hand and resulted in the longer absences from work than injuries from falls, accidents or fires. Cylindrical, tubular and rectangular handles are rolled flat structures. They place the hand on a rolled flat surface where the ends of the middle and ring fingers overlap the index and small fingers. They are pulled along a series of lines that contact the end joint of the index finger, the middle bones of the middle and ring fingers and the end bone of the small finger. Cylinders are pulled diagonally in the hand toward the carpal tunnel (CT) area. Gripping in this manner tenses asymmetric muscle groups in the forearm. Handles could work better if they do not place pressure on the CT and conform to the natural function or neutral hand position where the hand rests or dangles at the side of the body, the finger tips form a diagonal, the palm and fingers form a cup, the thumb rests between the index and middle fingers and the wrist is mildly extended. However, handles designed for the neutral position are pulled by diagonally oriented fingers into the valley between the thenar and hypothenar muscles where they can compress the median nerve and tendons exiting the CT. Seven principles for handles that do not place pressure on the carpal tunnel and employ optimal hand position are presented. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Tillim, S L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Bone KW - Accidents KW - Injuries KW - Conferences KW - Vibration KW - carpal tunnel syndrome KW - Occupational safety KW - overuse injuries KW - Muscles KW - Design KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Tillim%2C+S+L&rft.aulast=Tillim&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Handle+design+for+optimal+hand+function&rft.title=Handle+design+for+optimal+hand+function&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Use of tungsten to reduce vibration exposure in aircraft manufacturing AN - 19388794; 7157621 AB - Riveting operations in aircraft manufacturing involves the use of power tools for manually drilling holes for the rivets, power drills for the setting of the holes for the rivets, as well as rivet guns to drive and set the rivets. To close the rivet, the rivet is driven against a metallic bar commonly called a "bucking bar". The bucking bars are typically held firmly to increase the quality of the riveting, as well as keep the bucking bar from "dancing" against the metal piece being riveted. Thus, employees in aircraft manufacturing involved in riveting are exposed to hand-arm vibration from several sources, and epidemiological evidence suggests that vibration-related musculoskeletal disorders are associated with long term exposure to riveting tasks in the aircraft manufacturing of aircraft. Recently, tungsten technology has been introduced into aircraft manufacturing for bucking bars, which are heavier than traditional steel bucking bars of the same size. Rivet guns with tungsten pistons instead of steel pistons have also recently been introduced with the objective of reducing vibration exposure to the riveter. The objective of this study was to assess vibration characteristics of steel and tungsten bucking bars and rivet guns to identify the combination that simultaneously reduced the combined exposure to both the "riveter" and "bucker". JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jorgensen, MJ AU - Khan, K S AU - Polsani, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Aircraft KW - Conferences KW - Vibration KW - Steel KW - Occupational exposure KW - musculoskeletal system KW - Tungsten KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jorgensen%2C+MJ%3BKhan%2C+K+S%3BPolsani%2C+A&rft.aulast=Jorgensen&rft.aufirst=MJ&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+tungsten+to+reduce+vibration+exposure+in+aircraft+manufacturing&rft.title=Use+of+tungsten+to+reduce+vibration+exposure+in+aircraft+manufacturing&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Measuring physiological and biochemical changes in work-related vibration AN - 19388026; 7157579 AB - Until now there has been controversy about which tests should be performed to diagnose early Hand-Arm Vibration Syndrome (HAVS). Initial screening questions, especially about tingling and numbness, routinely given to patients prior to examinations proved to be a very important tool in the diagnostic process. However, standardized tests that are simple, quick, valid and reliable are needed to support a diagnosis of HAVS. Purpose: To find the most valid and reliable tests to diagnose HAVS. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Yan, J-G AU - Matloub, H S AU - Zhang, L-L AU - Sanger, J R AU - Yan, Y AU - Riley, DA AU - Agresti, M AU - Rowe, D AU - Galaviz, P AU - Marchant-Hanson, J AU - Lifchez, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - Physiology KW - hand-arm vibration syndrome KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Yan%2C+J-G%3BMatloub%2C+H+S%3BZhang%2C+L-L%3BSanger%2C+J+R%3BYan%2C+Y%3BRiley%2C+DA%3BAgresti%2C+M%3BRowe%2C+D%3BGalaviz%2C+P%3BMarchant-Hanson%2C+J%3BLifchez%2C+S&rft.aulast=Yan&rft.aufirst=J-G&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Measuring+physiological+and+biochemical+changes+in+work-related+vibration&rft.title=Measuring+physiological+and+biochemical+changes+in+work-related+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Prospective studies of vibration exposed cohorts: Hand-arm vibration international consortium (HAVIC) AN - 19388006; 7157577 AB - HAVIC is a collaboration of investigators from North America, Sweden, and Finland having a scientific mandate from NIOSH, to study the exposure response relationship between vibratory tool exposure and adverse health effects. Five cohorts, the Suomossalmi forest workers cohort, Volvo truck cab workers, Connecticut shipyard workers, and matriculating dental hygiene students and experienced dental hygienists have been under study. In the case of shipyard workers, there was survey and tool exposure data from 1988, although detailed subject testing was only available within the timeframe of the study. The truck cab assembly workforce was an inception cohort that had been followed from 1994 along with age-matched controls. The Finnish forest workers had cumulative health data on a cohort (n=52) that had been studied from 1976. For a subset of these subjects, there was detailed tactometry testing in 1990, 1995, and 2003. Accordingly, there was historical as well as new prospective data for the industrial cohorts. The Suomossalmi cohort was reassembled only for our study, which precluded follow-up evaluation and because of retirement is almost certainly the last time this historic group will be studied. The study features are: Characterization of the exposure response relationship for hand-arm vibration through a study design, incorporating multiple cohorts, some having existing historical data, Selection of cohorts to include different types of vibration: oscillatory (forest workers) impact (truck cab workers), high frequency (dental hygienists) and mixed (shipyard workers), Inclusion of two inception cohorts: dental hygiene students and Swedish truck cab workers, Methods for multi-site and historical integration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Cherniack, M AU - Brammer, A J AU - Lundstrom, R AU - Meyer, J D AU - Morse, T F AU - Neely, G AU - Nilsson, T AU - Peterson, D AU - Toppila, E AU - Warren, N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Conferences KW - Finland KW - USA, Connecticut KW - Vibration KW - Forests KW - Trucks KW - Occupational exposure KW - Medical personnel KW - Sweden KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cherniack%2C+M%3BBrammer%2C+A+J%3BLundstrom%2C+R%3BMeyer%2C+J+D%3BMorse%2C+T+F%3BNeely%2C+G%3BNilsson%2C+T%3BPeterson%2C+D%3BToppila%2C+E%3BWarren%2C+N&rft.aulast=Cherniack&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Prospective+studies+of+vibration+exposed+cohorts%3A+Hand-arm+vibration+international+consortium+%28HAVIC%29&rft.title=Prospective+studies+of+vibration+exposed+cohorts%3A+Hand-arm+vibration+international+consortium+%28HAVIC%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A pilot study of the transmissibility of the rat tail compared to that of the human finger AN - 19387349; 7157597 AB - Continual occupational exposure to vibrating hand tools can damage the neural, vascular and other soft tissues of the fingers. Rat tail models have been developed to investigate the biological responses of the tissues to vibration. However, the biodynamic response of the tail relative to that of the human fingers has not been characterized. The objective of this pilot study was to compare the transmissibilities of rat tails measured via a scanning laser vibrometer to those of human fingers gripping a handle. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Welcome, D AU - Dong, R G AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Vibration KW - Working conditions KW - hand tools KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Welcome%2C+D%3BDong%2C+R+G%3BKrajnak%2C+K+M&rft.aulast=Welcome&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+pilot+study+of+the+transmissibility+of+the+rat+tail+compared+to+that+of+the+human+finger&rft.title=A+pilot+study+of+the+transmissibility+of+the+rat+tail+compared+to+that+of+the+human+finger&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A multi-body dynamic biomechanical model of a seated human exposed to vertical whole-body vibration AN - 19387328; 7157595 AB - Ethical concerns of in-vivo procedures and poor repeatability of non-invasive techniques have been major limitations in estimating vibration-induced spine loads through experiments. The biodynamic models of seated human body exposed to whole-body vibration (WBV) have evolved for defining the frequency-weightings, enhancement of human responses to WBV, and developing anthropodynamic manikins for seating assessment activities. The widely reported mechanical-equivalent models, solely based on through- or to-the-body biodynamic response functions, do not seem to resemble the biomechanical structure and do not yield information on the dynamic loading and deflections of segments of concern, namely the spine. On the other hand, biomechanical models with representative anatomical structure and anthropometry are being attempted to simulate segmental movements and the coupling effects, using Finite elements (FE) or multi-body dynamics (MBD) formalisms, which could provide important insights into the inter-vertebral forces. While the FE models pose considerable complexities primarily related to characteristics of the bio-material properties, the MBD technique with discrete rigid bodies offers the flexibility to create multi-segment models with relative ease and lower computational cost. In this study, a preliminary multibody dynamic model of a seated human body exposed to WBV along the vertical direction is formulated using MSC/ADAMS software. The model validity is demonstrated by comparing selected responses with the available measured data. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Pranesh, A AU - Rakheja, S AU - Demont, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Computer programs KW - spine KW - Vibration KW - biomechanics KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pranesh%2C+A%3BRakheja%2C+S%3BDemont%2C+R&rft.aulast=Pranesh&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+multi-body+dynamic+biomechanical+model+of+a+seated+human+exposed+to+vertical+whole-body+vibration&rft.title=A+multi-body+dynamic+biomechanical+model+of+a+seated+human+exposed+to+vertical+whole-body+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Regional cerebral oxygenation and blood volume responses in healthy women during seated whole-body vibration (WBV) AN - 19387300; 7157585 AB - Landstrom et al. (1985) suggested the possibility of cortical activation during exposure to WBV, however, it is not known how cerebral physiology (oxygenation and blood volume) responds in healthy women during different vibration frequencies. This study examined the role of backrest support and handgrip work on cerebral oxygenation and blood volume responses, during exposure to seated WBV. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Maikala, R V AU - Bhambhani, Y N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Blood KW - Vibration KW - Physiology KW - Oxygenation KW - Females KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Maikala%2C+R+V%3BBhambhani%2C+Y+N&rft.aulast=Maikala&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Regional+cerebral+oxygenation+and+blood+volume+responses+in+healthy+women+during+seated+whole-body+vibration+%28WBV%29&rft.title=Regional+cerebral+oxygenation+and+blood+volume+responses+in+healthy+women+during+seated+whole-body+vibration+%28WBV%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Numerical models and hardware dummies for simulating whole-body vibration of human - an overview AN - 19387258; 7157574 AB - The goal of biodynamic models is to simulate the vibration behaviour of the human body. In combination with experimental studies biodynamical models can be a powerful tool for the analysis of the effects of vibration exposure on health and comfort. This paper gives an overview of the state of the art of biodynamic whole-body vibration models of humans, addressing both numerical models and hardware dummies. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - WOelfel, H P Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mathematical models KW - Vibration KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=WOelfel%2C+H+P&rft.aulast=WOelfel&rft.aufirst=H&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Numerical+models+and+hardware+dummies+for+simulating+whole-body+vibration+of+human+-+an+overview&rft.title=Numerical+models+and+hardware+dummies+for+simulating+whole-body+vibration+of+human+-+an+overview&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Modifiable Environmental and Behavioral Determinants of Overweight among Children and Adolescents: Report of a Workshop AN - 19366975; 7129867 AB - The number of children at risk for overweight and the number of overweight children are increasing and have become a serious public health concern. Interventions that could be applied at the population level have not been proven effective. The development of effective strategies is thought to be hampered by the lack of understanding of which behavioral and environmental factors need to be modified. On June 14 and 15, 2004, the NIH held a meeting of experts to discuss the issue of modifiable determinants of obesity in children and adolescents. Included were presentations on interventions among children that have been proven effective, dietary and physical activity behavioral determinants, physical, social, and family environmental determinants, and the quality of measures of determinants and correlates of overweight. JF - Obesity Research AU - Johnson-Taylor, Wendy L AU - Everhart, James E AD - Division of Nutrition Research Coordination, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Clinical Trials Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 929 EP - 966 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Issues KW - Adolescence KW - Strategy KW - Family KW - Exercise KW - Children KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Modifiable+Environmental+and+Behavioral+Determinants+of+Overweight+among+Children+and+Adolescents%3A+Report+of+a+Workshop&rft.au=Johnson-Taylor%2C+Wendy+L%3BEverhart%2C+James+E&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2006-06-01&rft.volume=14&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Issues; Adolescence; Strategy; Family; Exercise; Children; Public health ER - TY - JOUR T1 - Genetic Requirements for Growth of Escherichia coli K12 on Methyl- alpha -D-glucopyranoside and the Five alpha -D-Glucosyl-D-fructose Isomers of Sucrose AN - 17258135; 6996402 AB - Strains of Escherichia coli K12, including MG-1655, accumulate methyl- alpha -D-glucopyranoside via the phosphoenolpyruvate-dependent glucose:phosphotransferase system (IICB super(Glc)/IIA super(Glc)). High concentrations of intracellular methyl- alpha -D-glucopyranoside 6-phosphate are toxic, and cell growth is prevented. However, transformation of E. coli MG-1655 with a plasmid (pAP1) encoding the gene aglB from Klebsiella pneumoniae resulted in excellent growth of the transformant MG-1655 (pAP1) on the glucose analog. AglB is an unusual NAD super(+)/Mn super(2+)-dependent phospho- alpha -glucosidase that promotes growth of MG-1655 (pAP1) by catalyzing the in vivo hydrolysis of methyl- alpha -D-glucopyranoside 6-phosphate to yield glucose 6-phosphate and methanol. When transformed with plasmid pAP2 encoding the K. pneumoniae genes aglB and aglA (an alpha -glucoside-specific transporter AglA (IICB super(Agl))), strain MG-1655 (pAP2) metabolized a variety of other alpha -linked glucosides, including maltitol, isomaltose, and the following five isomers of sucrose: trehalulose alpha (1 arrow right 1), turanose alpha (1 arrow right 3), maltulose alpha (1 arrow right 4), leucrose alpha (1 arrow right 5), and palatinose alpha (1 arrow right 6). Remarkably, MG-1655 (pAP2) failed to metabolize sucrose alpha (1 arrow right 2). The E. coli K12 strain ZSC112L (ptsG::cat manXYZ nagE glk lac) can neither grow on glucose nor transport methyl- alpha -D-glucopyranoside. However, when transformed with pTSGH11 (encoding ptsG) or pAP2, this organism provided membranes that contained either the PtsG or AglA transporters, respectively. In vitro complementation of transporter-specific membranes with purified general phosphotransferase components showed that although PtsG and AglA recognized glucose and methyl- alpha -D-glucopyranoside, only AglA accepted other alpha -D-glucosides as substrates. Complementation experiments also revealed that IIA super(Glc) was required for functional activity of both PtsG and AglA transporters. We conclude that AglA, AglB, and IIA super(Glc) are necessary and sufficient for growth of E. coli K12 on methyl- alpha -D-glucoside and related alpha -D-glucopyranosides. JF - Journal of Biological Chemistry AU - Pikis, Andreas AU - Hess, Sonja AU - Arnold, Ingrid AU - Erni, Bernhard AU - Thompson, John AD - Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, NIDCR, and the Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 and the Departement fuer Chemie und Biochemie, Universitaet Bern, CH-3012 Bern, Switzerland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17900 EP - 17908 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 26 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Transformation KW - Methanol KW - phosphotransferase KW - Plasmids KW - glucosides KW - Hydrolysis KW - Isomers KW - Growth KW - Complementation KW - Sucrose KW - Glucose transport KW - Escherichia coli KW - Klebsiella pneumoniae KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17258135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Genetic+Requirements+for+Growth+of+Escherichia+coli+K12+on+Methyl-+alpha+-D-glucopyranoside+and+the+Five+alpha+-D-Glucosyl-D-fructose+Isomers+of+Sucrose&rft.au=Pikis%2C+Andreas%3BHess%2C+Sonja%3BArnold%2C+Ingrid%3BErni%2C+Bernhard%3BThompson%2C+John&rft.aulast=Pikis&rft.aufirst=Andreas&rft.date=2006-06-01&rft.volume=281&rft.issue=26&rft.spage=17900&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Growth; Complementation; Sucrose; Methanol; Glucose transport; phosphotransferase; glucosides; Plasmids; Hydrolysis; Isomers; Escherichia coli; Klebsiella pneumoniae ER - TY - JOUR T1 - Immunologic Consequences of Francisella tularensis Live Vaccine Strain Infection: Role of the Innate Immune Response in Infection and Immunity AN - 17240406; 6948147 AB - Francisella tularensis (Ft), a Gram-negative intracellular bacterium, is the etiologic agent of tularemia. Although attenuated for humans, i.p. infection of mice with 10 super(6) organisms. To examine the immunological consequences of Ft LVS infection on the innate immune response, the inflammatory responses of mice infected i.p. or intradermally were compared. Mice infected i.p. displayed greater bacterial burden and increased expression of proinflammatory genes, particularly in the liver. In contrast to most LPS, highly purified Ft LVS LPS (10 mu g/ml) was found to be only minimally stimulatory in primary murine macrophages and in HEK293T cells transiently transfected with TLR4/MD-2/CD14, whereas live Ft LVS bacteria were highly stimulatory for macrophages and TLR2-expressing HEK293T cells. Despite the poor stimulatory activity of Ft LVS LPS in vitro, administration of 100 ng of Ft LVS LPS 2 days before Ft LVS challenge severely limited both bacterial burden and cytokine mRNA and protein expression in the absence of detectable Ab at the time of bacterial challenge, yet these mice developed a robust IgM Ab response within 2 days of infection and survived. These data suggest that prior administration of Ft LVS LPS protects the host by diminishing bacterial burden and blunting an otherwise overwhelming inflammatory response, while priming the adaptive immune response for development of a strong Ab response. JF - Journal of Immunology AU - Cole, Leah E AU - Elkins, Karen L AU - Michalek, Suzanne M AU - Qureshi, Nilofer AU - Eaton, Linda J AU - Rallabhandi, Prasad AU - Cuesta, Natalia AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research/Food and Drug Administration, Bethesda, MD 20852. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294. Department of Basic Medical Science and/or Surgery, Shock/Trauma Research Center, University of Missouri-Kansas City, School of Medicine, Kansas City, MO 64108. List Biological Laboratories, Campbell, CA 95008 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 6888 EP - 6899 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 11 SN - 0022-1767, 0022-1767 KW - innate immunity KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Francisella tularensis KW - Antibody response KW - Infection KW - CD14 antigen KW - mRNA KW - Inflammation KW - Gene expression KW - Tularemia KW - Liver KW - Cytokines KW - Lipopolysaccharides KW - Vaccines KW - Immune response KW - TLR4 protein KW - Immunoglobulin M KW - Toll-like receptors KW - F 06100:Vaccines - active immunity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17240406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Immunologic+Consequences+of+Francisella+tularensis+Live+Vaccine+Strain+Infection%3A+Role+of+the+Innate+Immune+Response+in+Infection+and+Immunity&rft.au=Cole%2C+Leah+E%3BElkins%2C+Karen+L%3BMichalek%2C+Suzanne+M%3BQureshi%2C+Nilofer%3BEaton%2C+Linda+J%3BRallabhandi%2C+Prasad%3BCuesta%2C+Natalia%3BVogel%2C+Stefanie+N&rft.aulast=Cole&rft.aufirst=Leah&rft.date=2006-06-01&rft.volume=176&rft.issue=11&rft.spage=6888&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Antibody response; CD14 antigen; Infection; Inflammation; mRNA; Gene expression; Tularemia; Liver; Lipopolysaccharides; Cytokines; Immune response; Vaccines; TLR4 protein; Toll-like receptors; Immunoglobulin M; Francisella tularensis ER - TY - JOUR T1 - Determination of Airborne Isocyanates Generated During the Thermal Degradation of Car Paint in Body Repair Shops AN - 17232983; 6945016 AB - Polyurethanes are widely used in car paint formulations. During thermal degradation, such polymeric systems can generate powerful asthmatic sensitizing agents named isocyanates. In body repair shops, the thermal degradation of car paint can occur during abrasive processes that generate enough heat to involve release of isocyanates in air. An environmental monitoring study was performed in two body repair training schools and in a body repair shop to evaluate the workers' exposure to isocyanates during cutting, grinding and orbital sanding operations. For sampling, cassettes containing two 1-(2-methoxyphenyl)piperazine (MOPIP)-coated glass fiber filters (MFs) ( similar to 5 mg of MOPIP per filter) and bubblers containing 15 ml of MOPIP solution in toluene (1.0 mg ml super(-1)) backed at the outlet with cassettes containing two MFs were used. Tandem mass spectrometry was used to analyze the MOPIP derivatives of isocyanic acid (HNCO), all the linear aliphatic isocyanates ranging from methyl isocyanate (Me-i) to hexyl isocyanate, all the alkenyl isocyanates ranging from propylene isocyanate to hexylene isocyanate, 1,6-hexamethylene diisocyanate (HDI), trans- and cis-isophorone diisocyanate (IPDI), 2,4- and 2,6-toluene diisocyanate (TDI), 2,4'-; 2,2'- and 4,4'-methylenediphenyl diisocyanate (MDI), phenyl isocyanate (Ph-i) and p-toluene isocyanate (p-Tol-i). The instrumental detection limits (LOD) were in the 0.13-0.75 mu g of NCO per m super(3) range for 15 l air samples converted into 3 ml liquid samples. The isocyanate concentrations detected in the workers' breathing zone were in the 1.07-9.80 mu g of NCO per m super(3) range for cutting, 0.63-3.62 mu g of NCO per m super(3) range for grinding and 0-1.29 mu g of NCO per m super(3) range for sanding. However, a rapid decrease of the isocyanate concentration was observed while moving away from the emission source. Among the isocyanates detected the most abundant were the monomers (MDI, HDI, TDI and IPDI) and Me-i. JF - Annals of Occupational Hygiene AU - Boutin, Michel AU - Dufresne, Andre AU - Ostiguy, Claude AU - Lesage, Jacques AD - McGill University, 3450 University Street, FDA Building, Room 31, Montreal, Quebec, Canada H3A 2A7 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 385 EP - 393 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 50 IS - 4 SN - 0003-4878, 0003-4878 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Filters KW - Toluene KW - Automotive industry KW - Air sampling KW - Isocyanates KW - Occupational exposure KW - Industrial emissions KW - Paints KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Determination+of+Airborne+Isocyanates+Generated+During+the+Thermal+Degradation+of+Car+Paint+in+Body+Repair+Shops&rft.au=Boutin%2C+Michel%3BDufresne%2C+Andre%3BOstiguy%2C+Claude%3BLesage%2C+Jacques&rft.aulast=Boutin&rft.aufirst=Michel&rft.date=2006-06-01&rft.volume=50&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Filters; Toluene; Automotive industry; Air sampling; Isocyanates; Industrial emissions; Occupational exposure; Paints ER - TY - JOUR T1 - Completeness of cause of injury coding in healthcare administrative databases in the United States, 2001 AN - 17232833; 6947035 AB - OBJECTIVES: To determine the completeness of external cause of injury coding (E-coding) within healthcare administrative databases in the United States and to identify factors that contribute to variations in E-code reporting across states. DESIGN: Cross sectional analysis of the 2001 Healthcare Cost and Utilization Project (HCUP), including 33 State Inpatient Databases (SID), a Nationwide Inpatient Sample (NIS), and nine State Emergency Department Databases (SEDD). To assess state reporting practices, structured telephone interviews were conducted with the data organizations that participate in HCUP. RESULTS: The percent of injury records with an injury E-code was 86% in HCUP's nationally representative database, the NIS. For the 33 states represented in the SID, completeness averaged 87%, with more than half of the states reporting E-codes on at least 90% of injuries. In the nine states also represented in the SEDD, completeness averaged 93%. Twenty two states had mandates for E-code reporting, but only eight had provisions for enforcing the mandates. These eight states had the highest rates of E-code completeness. CONCLUSIONS: E-code reporting in administrative databases is relatively complete, but there is significant variation in completeness across the states. States with mandates for the collection of E-codes and with a mechanism to enforce those mandates had the highest rates of E-code reporting. Nine statewide ED data systems demonstrate consistently high E-coding completeness. JF - Injury Prevention AU - Coben, J H AU - Steiner, C A AU - Barrett, M AU - Merrill, C T AU - Adamson, D AD - Injury Control Research Center, West Virginia University, Morgantown, WV, USA. Agency for Healthcare Research and Quality, Center for Delivery, Organization, and Markets, Rockville, MD, USA. M.L. Barrett, Inc, San Diego, CA, USA. Medstat, Washington, DC, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 199 EP - 201 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 12 IS - 3 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - USA KW - Data collection KW - Injuries KW - Health care KW - Data bases KW - Emergency medical services KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Completeness+of+cause+of+injury+coding+in+healthcare+administrative+databases+in+the+United+States%2C+2001&rft.au=Coben%2C+J+H%3BSteiner%2C+C+A%3BBarrett%2C+M%3BMerrill%2C+C+T%3BAdamson%2C+D&rft.aulast=Coben&rft.aufirst=J&rft.date=2006-06-01&rft.volume=12&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data collection; Health care; Injuries; Data bases; Emergency medical services; USA ER - TY - JOUR T1 - Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts AN - 17232482; 6950189 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies have been performed in mice or rabbits to determine where in the body these plasmid vaccines would biodistribute and how rapidly they would clear. In the course of these studies, it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis. Even though similar to 10 super(14) molecules are inoculated in the studies in rabbits, by day 8 or 9 ( similar to 1 week postinoculation), already all but on the order of 10 super(4)-10 super(6) molecules per microgram of DNA extracted from tissue have been cleared at the injection site. Over the course of 2 months, the plasmid clears from the site of injection with only a small percentage of animals (generally 10-20%) retaining a small number of copies (generally around 100 copies) in the muscle at the injection site. This pattern of biodistribution (confined to the injection site) and clearance (within 2 months) is consistent regardless of differences in the promoter in the plasmid backbone or differences in the gene insert being expressed by the plasmid vaccine. In addition, integration has not been observed with plasmid vaccine candidates inoculated i.m. by Biojector 2000 or by needle and syringe. These data build on the repeated-dose toxicology studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Duffy, Chris AU - Nason, Martha AU - Andrews, Charla AU - Kong, Wing-Pui AU - Nabel, Gary J AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 610 EP - 619 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Severe acute respiratory syndrome KW - Muscles KW - Ebola virus KW - Adjuvants KW - Plasmids KW - Integration KW - Promoters KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Syringes KW - Cytokines KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - X 24240:Miscellaneous KW - N 14810:Methods KW - V 22004:AIDS: Clinical aspects KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Biodistribution+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar%2C+without+Integration%2C+despite+Differing+Plasmid+Backbones+or+Gene+Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BDuffy%2C+Chris%3BNason%2C+Martha%3BAndrews%2C+Charla%3BKong%2C+Wing-Pui%3BNabel%2C+Gary+J%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Muscles; Adjuvants; Plasmids; Promoters; Integration; DNA vaccines; Infectious diseases; DNA; Cytokines; Syringes; Vaccines; Immunoglobulins; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - Dietary Modulation of p-Nonylphenol-Induced Polycystic Kidneys in Male Sprague-Dawley Rats AN - 17231474; 6950191 AB - We had previously found that p-nonylphenol (NP) at 1000-2000 ppm in a soy- and alfalfa-free diet induced severe polycystic kidney disease (PKD) in both male and female pups exposed from gestation day 7 through postnatal day (PND) 50 and hypothesized that differences in dietary components contributed to the severity of lesions relative to those reported in other studies using similar doses of NP. The present study investigated the dietary modulation of NP-induced PKD using the same exposure regimen with 2000 ppm NP in four different diets: the natural ingredient soy- and alfalfa-free diet that had been used in the earlier study, Purina 5K96; two defined diets AIN-93G, designated AIN-CAS, and a modified AIN-93G with soy protein isolate replacing casein as the protein source (AIN-SPI); and the commonly used natural ingredient diet Purina 5001 (P5001). Serum isoflavone levels were negligible in animals fed the soy-free AIN-CAS and 5K96 diets and were 2- to 18-fold higher in animals fed P5001 than in those fed AIN-SPI. Consumption of P5001 was significantly greater than consumption of the other diets, and those animals fed P5001 were generally significantly heavier than animals receiving the other diets. NP significantly reduced body weight gain in male pups regardless of the diet fed. There was no evidence of NP-induced kidney toxicity in male pups at PND 2, 14, or 21 or in the dams. In PND 50 male pups, serum blood urea nitrogen was significantly elevated by NP in all diet groups. Urine volume and urinary N-acetyl {beta}-glucuronidase were significantly increased by NP in the soy-free 5K96 and AIN-CAS diet groups. Relative kidney weights were increased by NP in all diet groups except P5001, with the greatest increase in AIN-CAS and 5K96 diet groups. Microscopic evaluation of kidneys from the PND 50 males showed that NP induced PKD in all diet groups but with marked variation in the severity depending on the diet. PKD was severe in 100% of the NP-treated animals in the AIN-CAS and 5K96 groups, moderate in 88% of the AIN-SPI diet group, and mild in only 40% of the P5001 diet group. Thus, diet can significantly modulate the development of PKD induced by dietary NP in rats. Soy components, as well as other complex dietary factors, may account for the level of protection afforded by the P5001 diet. JF - Toxicological Sciences AU - Cooper, Steven AU - Latendresse, John R AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Fu, Xin AU - Delclos, KBarry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 631 EP - 642 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Diets KW - Polycystic kidney KW - Urea KW - 4-Nonylphenol KW - Toxicity KW - Casein KW - Soybeans KW - Protein sources KW - Blood KW - Urine KW - Gestation KW - Kidney KW - Isoflavone KW - Body weight gain KW - Nitrogen KW - X 24154:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17231474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Dietary+Modulation+of+p-Nonylphenol-Induced+Polycystic+Kidneys+in+Male+Sprague-Dawley+Rats&rft.au=Cooper%2C+Steven%3BLatendresse%2C+John+R%3BDoerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BFu%2C+Xin%3BDelclos%2C+KBarry&rft.aulast=Cooper&rft.aufirst=Steven&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Polycystic kidney; Urea; Toxicity; 4-Nonylphenol; Casein; Soybeans; Protein sources; Blood; Urine; Gestation; Isoflavone; Kidney; Body weight gain; Nitrogen ER - TY - JOUR T1 - An Evaluation of Conditions That May Affect the Performance of Houseboat Exhaust Stacks in Prevention of Carbon Monoxide Poisonings from Generators AN - 17229739; 6943887 AB - National Institute for Occupational Safety and Health (NIOSH) researchers evaluated two exhaust stack designs for reducing carbon monoxide (CO) exposures from gasoline-powered generator exhaust on houseboats. Tests were conducted (a) after dark, (b) in high-temperature and high-humidity environments, (c) during temperature inversions, (d) under various generator loads, and (e) at different houseboat trim angles. Two different designs of houseboat exhaust stacks were evaluated and compared with the side-exhaust configuration, which is standard on many houseboats. The two designs were flagpole and vertical stack. Both exhaust stacks performed dramatically better than the standard water level, side-exhaust configuration. The highest mean CO concentrations on the upper and lower decks of the houseboat with the vertical exhaust stack were 27 ppm and 17 ppm. The highest mean CO concentrations on the upper and lower decks of the houseboat with the modified flagpole stack were 5 ppm and 2 ppm. These findings are much lower than the 67 ppm and 341 ppm for the highest mean CO concentrations found on the upper and lower decks of houseboats having the usual side-exhausted configuration. The NIOSH evaluation also indicated that high-temperature and high-humidity levels, temperature inversions, generator loading, and houseboat trim angles had little effect on the exhaust stack performance. It also demonstrated the importance of proper design and installation of exhaust stacks to ensure that all exhaust gases are released through the stack. Based on the results of this work, NIOSH investigators continue to recommend that houseboat manufacturers, rental companies, and owners retrofit their gasoline-powered generators with exhaust stacks to reduce the hazard of CO poisoning and death to individuals on or near the houseboat. JF - Journal of Occupational and Environmental Hygiene AU - Hammond AU - Earnest, G S AU - Hall, R M AU - Feng, A AD - NIOSH, Division of Applied Research and Technogy, 4676 Columbia Parkway, MS-R5, Cincinnati, Ohio 45226, USA, ahz0@cdc.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 308 EP - 316 VL - 3 IS - 6 SN - 1545-9624, 1545-9624 KW - house boats KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Carbon monoxide KW - Inhalation KW - Mortality KW - Gasoline KW - Temperature KW - Poisoning KW - prevention KW - Stack emissions KW - H 14000:Toxicology KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17229739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=An+Evaluation+of+Conditions+That+May+Affect+the+Performance+of+Houseboat+Exhaust+Stacks+in+Prevention+of+Carbon+Monoxide+Poisonings+from+Generators&rft.au=Hammond%3BEarnest%2C+G+S%3BHall%2C+R+M%3BFeng%2C+A&rft.aulast=Hammond&rft.aufirst=&rft.date=2006-06-01&rft.volume=3&rft.issue=6&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600691249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Carbon monoxide; Mortality; Gasoline; prevention; Poisoning; Temperature; Stack emissions DO - http://dx.doi.org/10.1080/15459620600691249 ER - TY - JOUR T1 - Pesticides associated with Wheeze among Commercial Pesticide Applicators in the Agricultural Health Study AN - 17227252; 6944919 AB - Pesticides are potential risk factors for respiratory disease among farmers, but farmers are also exposed to other respiratory toxicants. To explore the association of pesticides with wheeze in a population without other farming exposures, the authors analyzed data from 2,255 Iowa commercial pesticide applicators enrolled in the Agricultural Health Study. Controlling for age, smoking status, asthma and atopy history, and body mass index, the authors calculated odds ratios for the relationship between wheeze and 36 individual pesticides participants had used during the year before enrollment (1993-1997). Eight of 16 herbicides were associated with wheeze in single-agent models; however, the risk was almost exclusively associated with the herbicide chlorimuron-ethyl (odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.25, 2.10). Inclusion of chlorimuron-ethyl in models for the other herbicides virtually eliminated the associations. The odds ratios for four organophosphate insecticides (terbufos, fonofos, chlorpyrifos, and phorate) were elevated when these chemicals were modeled individually and remained elevated, though attenuated somewhat, when chlorimuron-ethyl was included. The association for dichlorvos, another organophosphate insecticide, was not attenuated by chlorimuron-ethyl (OR = 2.48, 95% CI: 1.08, 5.66). Dose-response trends were observed for chlorimuron-ethyl, chlorpyrifos, and phorate; the strongest odds ratio was for applying chlorpyrifos on more than 40 days per year (OR = 2.40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl. JF - American Journal of Epidemiology AU - Hoppin, Jane A AU - Umbach, David M AU - London, Stephanie J AU - Lynch, Charles F AU - Alavanja, Michael CR AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1129 EP - 1137 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 163 IS - 12 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Toxicants KW - Organophosphates KW - phorate KW - Respiratory diseases KW - Models KW - Smoking KW - Insecticides KW - Dose-response effects KW - Risk factors KW - Occupational exposure KW - Dichlorvos KW - Data processing KW - Asthma KW - Herbicides KW - organophosphates KW - Agrochemicals KW - Chlorpyrifos KW - Atopy KW - USA, Iowa KW - Pesticides KW - Body mass index KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17227252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Pesticides+associated+with+Wheeze+among+Commercial+Pesticide+Applicators+in+the+Agricultural+Health+Study&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+CR%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-06-01&rft.volume=163&rft.issue=12&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Toxicants; phorate; Asthma; Herbicides; organophosphates; Models; Chlorpyrifos; Smoking; Insecticides; Atopy; Risk factors; Pesticides; Body mass index; Dichlorvos; Organophosphates; Dose-response effects; Respiratory diseases; Agrochemicals; Occupational exposure; USA, Iowa ER - TY - JOUR T1 - Using induced accelerations to understand knee stability during gait of individuals with muscle weakness AN - 17168131; 6836826 AB - The purpose of this case series was to quantify the effectiveness of different compensatory strategies used by individuals with muscle weakness to produce knee extension during the stance phase gait. Subjects were three males with less than anti-gravity strength in the quadriceps femoris and a variable pattern of weakness elsewhere in the lower extremity. They walked independently at a self-selected speed without assistive devices. Gait analysis of the pelvis and bilateral lower extremity segments was performed with a six-camera, two force platform motion capture system. Joint angles and net internal moments were computed from the motion data. Induced acceleration analysis was performed to quantify the relative ability of each lower extremity joint moment and gravity to produce knee angular acceleration. Results showed that a variety of adaptive strategies both within and across limbs can control knee position during gait. One subject generated knee extension almost exclusively via the hip extensor moment. Another relied less on the hip extensor moment (39%) and more on the ankle plantar flexor moment (61%) to create knee extension. The third subject used the ipsilateral hip extensor moment (24%) and the contralateral ankle plantar flexor moment (67%) to assist knee extension. The strategy selected by each subject likely was influenced by both their total pattern of impairments and the effectiveness of the available compensations. This case series demonstrates how an induced acceleration analysis can augment a traditional gait analysis to expand and enhance our understanding of compensatory movement control strategies. JF - Gait & Posture AU - Siegel, Karen Lohmann AU - Kepple, Thomas M AU - Stanhope, Steven J AD - Physical Disabilities Branch, National Institutes of Health, Department of Health and Human Services, Building 10, CRC, Room 1-1469, 10 Center Drive, MSC 1604, Bethesda, MD 20892, USA, karen_siegel@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 435 EP - 440 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 23 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Weakness KW - Gait KW - Quadriceps femoris KW - Compensation KW - Motor control KW - Gravity KW - Strategy KW - Force platforms KW - Ankles KW - Knees KW - Legs KW - Muscles (fatigue) KW - Stability KW - Movement KW - Acceleration KW - Hips KW - Joints KW - Pelvis KW - Speed KW - Strength KW - Analysis KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Using+induced+accelerations+to+understand+knee+stability+during+gait+of+individuals+with+muscle+weakness&rft.au=Siegel%2C+Karen+Lohmann%3BKepple%2C+Thomas+M%3BStanhope%2C+Steven+J&rft.aulast=Siegel&rft.aufirst=Karen&rft.date=2006-06-01&rft.volume=23&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2005.05.007 LA - English DB - Physical Education Index N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gravity; Force platforms; Strategy; Knees; Ankles; Legs; Muscles (fatigue); Stability; Acceleration; Movement; Hips; Joints; Pelvis; Strength; Speed; Analysis; Gait; Motor control DO - http://dx.doi.org/10.1016/j.gaitpost.2005.05.007 ER - TY - RPRT T1 - Your Rights under Section 504 of the Rehabilitation Act. Fact Sheet AN - 1697491294; ED553179 AB - Section 504 of the Rehabilitation Act of 1973 is a national law that protects qualified individuals from discrimination based on their disability. The nondiscrimination requirements of the law apply to employers and organizations that receive financial assistance from any Federal department or agency, including the U.S. Department of Health and Human Services (DHHS). These organizations and employers include many hospitals, nursing homes, mental health centers and human service programs. Section 504 forbids organizations and employers from excluding or denying individuals with disabilities an equal opportunity to receive program benefits and services. It defines the rights of individuals with disabilities to participate in, and have access to, program benefits and services. This Fact Sheet outlines who is protected from discrimination, as well as prohibited discriminatory acts in health care and human services settings. Contact information on how to file a complaint of discrimination, or to obtain information of a civil rights nature, is also provided. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 2 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Rehabilitation Act 1973 (Section 504) KW - ERIC, Resources in Education (RIE) KW - Disability Discrimination KW - Health Services KW - Federal Legislation KW - Civil Rights KW - Eligibility KW - Civil Rights Legislation KW - Related Services (Special Education) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697491294?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - CPAPER T1 - Dietary Antioxidant Supplementation Enhances Aged Skeletal Muscle Adaptability to Repeated Exposures of Stretch-Shortening Contractions T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40130424; 4274300 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Cutlip, Robert G AU - Baker, Brent A AU - Geronilla, Ken B AU - Alway, Stephen E Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Skeletal muscle KW - Muscle contraction KW - Antioxidants KW - Dietary supplements KW - Adaptability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40130424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Dietary+Antioxidant+Supplementation+Enhances+Aged+Skeletal+Muscle+Adaptability+to+Repeated+Exposures+of+Stretch-Shortening+Contractions&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BGeronilla%2C+Ken+B%3BAlway%2C+Stephen+E&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic SSC-Exercise Results in Differential Physiological and Morphological Adaptation in Young and Old Rats T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40101771; 4275787 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Baker, Brent A AU - Geronilla, Kenneth B AU - Kashon, Mike L AU - Miller, Gerald R AU - Alway, Stephen E AU - Cutlip, Robert G Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Rats KW - Physiology KW - Adaptations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Chronic+SSC-Exercise+Results+in+Differential+Physiological+and+Morphological+Adaptation+in+Young+and+Old+Rats&rft.au=Baker%2C+Brent+A%3BGeronilla%2C+Kenneth+B%3BKashon%2C+Mike+L%3BMiller%2C+Gerald+R%3BAlway%2C+Stephen+E%3BCutlip%2C+Robert+G&rft.aulast=Baker&rft.aufirst=Brent&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stereological Analysis of Rat Skeletal Muscle Following Dietary Antioxidant Supplementation and Stretch-Shortening Cycle Exercise T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40088338; 4274301 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Mercer, Robert R AU - Baker, Brent A AU - Geronilla, Kenneth B AU - Alway, Stephen E AU - Cutlip, Robert G Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Skeletal muscle KW - Antioxidants KW - Dietary supplements KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40088338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Stereological+Analysis+of+Rat+Skeletal+Muscle+Following+Dietary+Antioxidant+Supplementation+and+Stretch-Shortening+Cycle+Exercise&rft.au=Mercer%2C+Robert+R%3BBaker%2C+Brent+A%3BGeronilla%2C+Kenneth+B%3BAlway%2C+Stephen+E%3BCutlip%2C+Robert+G&rft.aulast=Mercer&rft.aufirst=Robert&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Measurement of Multisite Oxidation Kinetics Reveals an Active Site Conformational Change in Spo0F as a Result of Protein Oxidation AN - 19398659; 7156838 AB - When most proteins undergo oxidative damage, they yield a variety of products containing oxidative damage at a large number of sites, most of which are modified substoichiometrically. The resulting complex mixture of products is not amenable to high-resolution structural analyses. The previous methods of structural analysis have relied upon either very generalized structural analyses such as circular dichroism or the creation of a battery of mutants to try to isolate single-residue damage effects. We present a methodology using mass spectrometry to measure the kinetics of oxidation at many sites simultaneously. Previous studies have shown that these kinetics are determined by the chemical nature of the damage site and by the accessibility of that site to the radical. By measuring deviations in the rate of oxidation from the expected pseudo-zero-order kinetics, we can detect and characterize local structural changes due to the oxidative damage. We demonstrate the application of this new technique to the Spo0F protein, a regulator of sporulation in Bacillus subtilis. Circular dichroism studies suggest a partial loss of helical structure of Spo0F as a result of oxidative damage. We report that oxidation causes a three-stage conformational change in Spo0F. Furthermore, we find the dramatic structural changes affect only the region surrounding the active site, while the remainder of the structure remains relatively unperturbed. Finally, we are able to determine that the specific oxidation event that triggers the conformational change at the active site of Spo0F occurs at Met81, a partially conserved methionine in the CheY superfamily. JF - Biochemistry (Washington) AU - Sharp, J S AU - Sullivan, D M AU - Cavanagh, J AU - Tomer, K B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 SP - 6260 EP - 6266 VL - 45 IS - 20 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Kinetics KW - C.D. KW - Oxidation KW - Sporulation KW - Mass spectroscopy KW - Methionine KW - Radicals KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19398659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Measurement+of+Multisite+Oxidation+Kinetics+Reveals+an+Active+Site+Conformational+Change+in+Spo0F+as+a+Result+of+Protein+Oxidation&rft.au=Sharp%2C+J+S%3BSullivan%2C+D+M%3BCavanagh%2C+J%3BTomer%2C+K+B&rft.aulast=Sharp&rft.aufirst=J&rft.date=2006-05-23&rft.volume=45&rft.issue=20&rft.spage=6260&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi060470r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - C.D.; Kinetics; Oxidation; Sporulation; Methionine; Mass spectroscopy; Radicals; Bacillus subtilis DO - http://dx.doi.org/10.1021/bi060470r ER - TY - CPAPER T1 - Animal Rule Regulatory Issues T2 - 106th General Meeting of the American Society for Microbiology AN - 40150625; 4152788 JF - 106th General Meeting of the American Society for Microbiology AU - Schrager, Lewis K Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Bioterrorism KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Animal+Rule+Regulatory+Issues&rft.au=Schrager%2C+Lewis+K&rft.aulast=Schrager&rft.aufirst=Lewis&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enterobacter sakazakii in Spray-Dried Infant Formula T2 - 106th General Meeting of the American Society for Microbiology AN - 40150556; 4152763 JF - 106th General Meeting of the American Society for Microbiology AU - Buchanan, Robert L Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Infant formulas KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Enterobacter+sakazakii+in+Spray-Dried+Infant+Formula&rft.au=Buchanan%2C+Robert+L&rft.aulast=Buchanan&rft.aufirst=Robert&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimal Response Adaptive Biased Coin Designs for Randomization to More than Two Treatment Arms T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40128474; 4270142 DE: JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Gwise, Thomas Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40128474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Optimal+Response+Adaptive+Biased+Coin+Designs+for+Randomization+to+More+than+Two+Treatment+Arms&rft.au=Gwise%2C+Thomas&rft.aulast=Gwise&rft.aufirst=Thomas&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Statistical Design and Analysis Issues with Pharmacogenomic Drug-Diagnostic Co-Development T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40125772; 4270068 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Pennello, Gene Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Statistics KW - Pharmacogenomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40125772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Statistical+Design+and+Analysis+Issues+with+Pharmacogenomic+Drug-Diagnostic+Co-Development&rft.au=Pennello%2C+Gene&rft.aulast=Pennello&rft.aufirst=Gene&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Views from a Clinical Trials Participant: Issues Related to Subjective Patient Reported Outcome Responses Including a Comparison of Two Simulated Treatment Groups in which Extreme Values of Ordinal Responses are Under-Reported T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40123391; 4270161 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Massie, Tammy Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Clinical trials KW - Extreme values UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Views+from+a+Clinical+Trials+Participant%3A+Issues+Related+to+Subjective+Patient+Reported+Outcome+Responses+Including+a+Comparison+of+Two+Simulated+Treatment+Groups+in+which+Extreme+Values+of+Ordinal+Responses+are+Under-Reported&rft.au=Massie%2C+Tammy&rft.aulast=Massie&rft.aufirst=Tammy&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Stress Responses in Survival of Gram-Negative Pathogens in Non-PHFs T2 - 106th General Meeting of the American Society for Microbiology AN - 40076584; 4152764 JF - 106th General Meeting of the American Society for Microbiology AU - Zink, Don L Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Pathogens KW - Stress KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40076584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Role+of+Stress+Responses+in+Survival+of+Gram-Negative+Pathogens+in+Non-PHFs&rft.au=Zink%2C+Don+L&rft.aulast=Zink&rft.aufirst=Don&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What are Non-Potentially Hazardous Foods? T2 - 106th General Meeting of the American Society for Microbiology AN - 39166743; 4152760 JF - 106th General Meeting of the American Society for Microbiology AU - Woody, Jon Mikel Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39166743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=What+are+Non-Potentially+Hazardous+Foods%3F&rft.au=Woody%2C+Jon+Mikel&rft.aulast=Woody&rft.aufirst=Jon&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Fluorescein and Phycoerythrin Conjugates for Quantifying CD20 Expression on Normal and Leukemic Bcells T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40021577; 4219917 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Marti, Gerald AU - Wang, Lili AU - Abbasi, Fatima AU - Gaigalas, Adolfas AU - Vogt, Robert F Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Fluorescein KW - Leukemia KW - Phycoerythrins KW - CD20 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Comparison+of+Fluorescein+and+Phycoerythrin+Conjugates+for+Quantifying+CD20+Expression+on+Normal+and+Leukemic+Bcells&rft.au=Marti%2C+Gerald%3BWang%2C+Lili%3BAbbasi%2C+Fatima%3BGaigalas%2C+Adolfas%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiparameter Flow Cytometric Assays for the Study of Apoptosis T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 39949891; 4219972 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Bortner, Carl AU - Sifre, Maria AU - Cidlowski, John Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Multiparameter+Flow+Cytometric+Assays+for+the+Study+of+Apoptosis&rft.au=Bortner%2C+Carl%3BSifre%2C+Maria%3BCidlowski%2C+John&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Analysis of veterinary drug residues in shrimp: a multi-class method by liquid chromatography-quadrupole ion trap mass spectrometry. AN - 67965942; 16597519 AB - A liquid chromatography-mass spectrometry (LC-MS) method was developed to screen and confirm veterinary drug residues in raw shrimp meat. This method simultaneously monitors 18 drugs of different classes, including oxytetracycline (OTC), sulfonamides, quinolones, cationic dyes, and toltrazuril sulfone (TOLS). The homogenized shrimp meat is extracted with 5% trichloroacetic acid. The extract is further cleaned using polymer-based SPE. A 50 mm phenyl column separates the analytes, prior to analysis with an ion trap mass spectrometer interfaced with an atmospheric pressure chemical ionization source. This method is able to confirm oxytetracycline residues at 200 ng/g, toltrazuril sulfone at 50 ng/g, sulfaquinoxaline at 20 ng/g, and the other 15 drugs at 10 ng/g or lower levels. An estimate of the level of residues can also be made so that only confirmed samples above action levels will be sent for quantitation. The method is validated with both fortified and incurred samples, using multiple shrimp species as well. This multi-class method can provide a means to simultaneously monitor for a wide range of illegal drug residues in shrimp. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Li, Hui AU - Kijak, Philip James AU - Turnipseed, Sherri B AU - Cui, Wei AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD 20708, USA. Y1 - 2006/05/19/ PY - 2006 DA - 2006 May 19 SP - 22 EP - 38 VL - 836 IS - 1-2 SN - 1570-0232, 1570-0232 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Spectrometry, Fluorescence KW - Spectrophotometry, Ultraviolet KW - Quality Control KW - Crustacea -- chemistry KW - Veterinary Drugs -- analysis KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67965942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Analysis+of+veterinary+drug+residues+in+shrimp%3A+a+multi-class+method+by+liquid+chromatography-quadrupole+ion+trap+mass+spectrometry.&rft.au=Li%2C+Hui%3BKijak%2C+Philip+James%3BTurnipseed%2C+Sherri+B%3BCui%2C+Wei&rft.aulast=Li&rft.aufirst=Hui&rft.date=2006-05-19&rft.volume=836&rft.issue=1-2&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. AN - 67982844; 16707588 AB - On March 25, 2005, bortezomib (Velcade for Injection; Millennium Pharmaceuticals, Inc., Cambridge, MA, and Johnson & Johnson Pharmaceutical Research & Development, L.L.C.) received regular approval from the U.S. Food and Drug Administration (U.S. FDA) for the treatment of multiple myeloma (MM) progressing after at least one prior therapy. This approval was based on bortezomib's efficacy and safety which was shown in a single, large, comparative international open-label phase 3 trial that randomized 669 patients with MM previously treated with at least one systemic regimen to receive single-agent bortezomib or high-dose dexamethasone. The FDA analysis of the trial data and bortezomib's regulatory development are summarized here. Following a preplanned interim analysis of time to disease progression (the primary end point), an independent data-monitoring committee advised the sponsor to halt the study and offer bortezomib to all dexamethasone-treated study patients. Time to progression was significantly prolonged in the bortezomib treatment arm (median, 6.2 months) compared with the dexamethasone arm (median, 3.5 months; log-rank test, P < 0.0001; hazard ratio, 0.55; 95% confidence interval, 0.44-0.69). Analysis of overall survival done on the interim database (with 20% of events) showed the superiority of bortezomib for patients (log-rank test, P < 0.05; hazard ratio, 0.57; 95% confidence interval, 0.40-0.81). Using criteria from the European Group for Blood and Marrow Transplantation, the response rate (complete plus partial response) with bortezomib was also superior to dexamethasone (38% versus 18%; P < 0.0001). Adverse events on the bortezomib arm were similar to those previously observed in phase 2 studies; some notable adverse events included asthenia, peripheral neuropathy, thrombocytopenia, and neutropenia. The U.S. FDA had earlier (May 2003) granted bortezomib accelerated approval for the treatment of patients with MM progressing after two prior therapies. The results of the phase 3 trial and the FDA analysis of the data, along with the sponsor's completion of other postmarketing commitments, confirm bortezomib's benefit and support regular approval. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kane, Robert C AU - Farrell, Ann T AU - Sridhara, Rajeshwari AU - Pazdur, Richard AD - Division of Drug Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0004, USA. robert.kane@fda.hhs.gov Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 2955 EP - 2960 VL - 12 IS - 10 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Boronic Acids KW - Pyrazines KW - Bortezomib KW - 69G8BD63PP KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - United States KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Dexamethasone -- therapeutic use KW - Clinical Trials, Phase III as Topic KW - Humans KW - Disease Progression KW - Aged KW - United States Food and Drug Administration KW - Dexamethasone -- adverse effects KW - Middle Aged KW - Female KW - Male KW - Survival Analysis KW - Pyrazines -- therapeutic use KW - Multiple Myeloma -- drug therapy KW - Drug Approval KW - Boronic Acids -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Boronic Acids -- therapeutic use KW - Pyrazines -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67982844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=United+States+Food+and+Drug+Administration+approval+summary%3A+bortezomib+for+the+treatment+of+progressive+multiple+myeloma+after+one+prior+therapy.&rft.au=Kane%2C+Robert+C%3BFarrell%2C+Ann+T%3BSridhara%2C+Rajeshwari%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2006-05-15&rft.volume=12&rft.issue=10&rft.spage=2955&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-26 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus. AN - 67901240; 16504399 AB - Expression of the chemokine (C-C motif) ligand 2 (CCL2), also known as, monocyte chemoattractant protein (MCP)-1, increases in response to disease-, trauma-, or toxicant-induced damage to the central nervous system (CNS). In the periphery, endogenous and exogenous glucocorticoids are known to suppress CCL2 expression associated with inflammatory conditions. However, such actions of glucocorticoids on CCL2 expression in the CNS remain unknown. Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats. An immunosuppressive regimen of CORT did not alter the mRNA expression of CCL2 or its receptors in the hippocampus. ADX, however, markedly increased the expression of CCL2 and CCR2 mRNAs in the hippocampus, while CORT replacement reversed the effects of ADX on CCL2 gene expression. Hippocampal damage resulting from systemic administration of the organometallic neurotoxicant, TMT, was associated with microglial activation, as evidenced by enhanced expression of microglial markers integrin alphaM (CD11b) and F4/80, as well as, microglia-associated factors, CCL2 and IL-1alpha. An immunosuppressive dose of CORT, suppressed TMT-induced expression of CCL2. Given the association of CCL2 with microglial activation, it appears that CORT may play a role in regulating microglial activation. However, CORT treatment did not alter TMT-mediated neuronal damage and astrogliosis. Such observations suggest that injury-related expression of microglia-associated chemokines and cytokines may subserve a role unrelated to neuronal damage. In summary, our data indicate that in the CNS, CCL2 gene expression is under negative regulation by glucocorticoids. JF - Neuroscience letters AU - Little, Alvin R AU - Sriram, Krishnan AU - O'Callaghan, James P AD - Molecular Neurotoxicology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, CDC-NIOSH, TMBB-HELD, MS 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 162 EP - 166 VL - 399 IS - 1-2 SN - 0304-3940, 0304-3940 KW - Antigens, CD11b KW - 0 KW - Ccl2 protein, rat KW - Ccr2 protein, rat KW - Chemokine CCL2 KW - Glucocorticoids KW - Immunosuppressive Agents KW - RNA, Messenger KW - Receptors, CCR2 KW - Receptors, CCR5 KW - Receptors, Chemokine KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Rats, Long-Evans KW - Antigens, CD11b -- biosynthesis KW - Antigens, CD11b -- genetics KW - Astrocytes -- drug effects KW - Neurons -- drug effects KW - Receptors, Chemokine -- genetics KW - Adrenalectomy KW - Receptors, CCR5 -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Neurons -- pathology KW - Receptors, Chemokine -- biosynthesis KW - Rats KW - Gliosis -- pathology KW - Receptors, CCR5 -- genetics KW - Gliosis -- chemically induced KW - Astrocytes -- pathology KW - Male KW - Corticosterone -- metabolism KW - Chemokine CCL2 -- genetics KW - Hippocampus -- metabolism KW - Chemokine CCL2 -- biosynthesis KW - Hippocampus -- pathology KW - Corticosterone -- pharmacology KW - Trimethyltin Compounds -- toxicity KW - Glucocorticoids -- pharmacology KW - Immunosuppressive Agents -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67901240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Corticosterone+regulates+expression+of+CCL2+in+the+intact+and+chemically+injured+hippocampus.&rft.au=Little%2C+Alvin+R%3BSriram%2C+Krishnan%3BO%27Callaghan%2C+James+P&rft.aulast=Little&rft.aufirst=Alvin&rft.date=2006-05-15&rft.volume=399&rft.issue=1-2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Common Ground for the Control of Multidrug-Resistant Salmonella in Ground Beef AN - 19996130; 6858271 AB - A strategy to combat multidrug-resistant (MDR) Salmonella in ground beef is urgently needed. A national multi-disciplinary meeting reviewed the epidemiology of MDR Salmonella infection and contamination in humans, animals, and retail meat. In spite of a recent overall decrease in human MDR Salmonella isolates, certain types, such as Salmonella enterica serotype Newport multidrug-resistant-AmpC strain and Salmonella enterica serotype Typhimurium definitive type (DT) 104, have persisted, and several recent large outbreaks of human infection have occurred. Key agencies that contribute to a safe ground beef supply were represented at the meeting and contributed to the discussion of possible control strategies from the farm to the table. Several of the control strategies suggested are unpopular to some, including restricting the use of antimicrobial agents in food animals, designation of multidrug-resistant Salmonella as an adulterant in ground beef, and improving the mechanisms for product trace-back investigations. Nevertheless, enhanced farm-based animal infection control, judicious veterinary and human antibiotic use, regulatory controls, and consumer practices will lead to important industry, veterinary, and public health outcomes. JF - Clinical Infectious Diseases AU - Talbot, E A AU - Gagnon, E R AU - Greenblatt, J AD - New Hampshire Department of Health and Human Services, Concord, NH, USA Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 1455 EP - 1462 VL - 42 IS - 10 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Farms KW - Serotypes KW - Drug resistance KW - Food KW - Antibiotics KW - Food contamination KW - Infection KW - Antimicrobial agents KW - Public health KW - Meat KW - Epidemiology KW - Beef KW - Salmonella enterica KW - Reviews KW - Consumers KW - A 01019:Sterilization, preservation & packaging KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19996130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Common+Ground+for+the+Control+of+Multidrug-Resistant+Salmonella+in+Ground+Beef&rft.au=Talbot%2C+E+A%3BGagnon%2C+E+R%3BGreenblatt%2C+J&rft.aulast=Talbot&rft.aufirst=E&rft.date=2006-05-15&rft.volume=42&rft.issue=10&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serotypes; Farms; Food; Drug resistance; Antibiotics; Infection; Food contamination; Public health; Antimicrobial agents; Meat; Epidemiology; Beef; Reviews; Consumers; Salmonella enterica ER - TY - CPAPER T1 - Identification of Risk Factors Leading to Injuries Among Package Delivery Drivers T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40109603; 4241498 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Pan, C AU - Pratt, S AU - Hoskin, A AU - Lin, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Injuries KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40109603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Identification+of+Risk+Factors+Leading+to+Injuries+Among+Package+Delivery+Drivers&rft.au=Pan%2C+C%3BPratt%2C+S%3BHoskin%2C+A%3BLin%2C+M&rft.aulast=Pan&rft.aufirst=C&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Computer Database of Skin Sensitizers T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40108807; 4241729 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Fedorowicz, A AU - Michette, T Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Skin KW - Databases KW - Computers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40108807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Development+of+a+Computer+Database+of+Skin+Sensitizers&rft.au=Fedorowicz%2C+A%3BMichette%2C+T&rft.aulast=Fedorowicz&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Surrogate Standards for GC/MS Quantitation of Asphalt Fume Condensate T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40108733; 4241706 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Law, B AU - Stone, S AU - Frazer, D AU - Siegel, P Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Fumes KW - Guanylate cyclase KW - Condensates KW - Asphalt KW - Quantitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40108733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Surrogate+Standards+for+GC%2FMS+Quantitation+of+Asphalt+Fume+Condensate&rft.au=Law%2C+B%3BStone%2C+S%3BFrazer%2C+D%3BSiegel%2C+P&rft.aulast=Law&rft.aufirst=B&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Occupational Hygiene Capacity in Developing Nations, NIOSH Activities 1997-2005 T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107683; 4241531 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Sussell, A AU - Fingerhut, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Hygiene KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Building+Occupational+Hygiene+Capacity+in+Developing+Nations%2C+NIOSH+Activities+1997-2005&rft.au=Sussell%2C+A%3BFingerhut%2C+M&rft.aulast=Sussell&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Body Mass Index with Facial Dimensions for Defining Respirator Fit Panels T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107386; 4241500 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Roberge, R AU - Zhuang, Z AU - Stein, L Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Body mass index KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Association+of+Body+Mass+Index+with+Facial+Dimensions+for+Defining+Respirator+Fit+Panels&rft.au=Roberge%2C+R%3BZhuang%2C+Z%3BStein%2C+L&rft.aulast=Roberge&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Airborne Hexamethylene Diisocyanate and Particulate Exposures During Fire/Rescue Vehicle Ladder Finishing Operations T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107041; 4241718 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Methner, M AU - Achutan, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Particulates KW - Fires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Airborne+Hexamethylene+Diisocyanate+and+Particulate+Exposures+During+Fire%2FRescue+Vehicle+Ladder+Finishing+Operations&rft.au=Methner%2C+M%3BAchutan%2C+C&rft.aulast=Methner&rft.aufirst=M&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silo Explosion at a Lumber Company - A Case Study on Extinguishing a Fire in an Oxygen-Limiting Silo T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40106941; 4241684 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Berardinelli, S AU - Guglielmo, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Explosions KW - Fires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40106941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Silo+Explosion+at+a+Lumber+Company+-+A+Case+Study+on+Extinguishing+a+Fire+in+an+Oxygen-Limiting+Silo&rft.au=Berardinelli%2C+S%3BGuglielmo%2C+C&rft.aulast=Berardinelli&rft.aufirst=S&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fungal Genera and Species Observed on Wide Body Commercial Passenger Aircraft and Airport Terminals T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40106009; 4241575 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Taylor, L AU - Wallingford, K AU - Hein, M AU - Burge, H AU - Herrick, R Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Aircraft KW - Airports UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40106009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Fungal+Genera+and+Species+Observed+on+Wide+Body+Commercial+Passenger+Aircraft+and+Airport+Terminals&rft.au=Taylor%2C+L%3BWallingford%2C+K%3BHein%2C+M%3BBurge%2C+H%3BHerrick%2C+R&rft.aulast=Taylor&rft.aufirst=L&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Systems Approach to the Optimal Design of Safe Rooms for Shelter-in-Place Scenarios T2 - 8th International Conference on Ventilation (VENT 2006) AN - 40104165; 4241397 DE: JF - 8th International Conference on Ventilation (VENT 2006) AU - Bennett, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40104165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.atitle=A+Systems+Approach+to+the+Optimal+Design+of+Safe+Rooms+for+Shelter-in-Place+Scenarios&rft.au=Bennett%2C+J&rft.aulast=Bennett&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/aihce06/vent-sessions-ataglance.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Major Human Metabolite of Acetochlor in Exposed Herbicide Applicators by High Performance Liquid Chromatography-Tandem Mass Spectrometry T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40089525; 4241653 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Hines, C AU - Striley, C AU - Barr, D AU - Olsson, A AU - Bravo, R AU - Norrgran, J AU - Needham, L AU - Deddens, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Mass spectroscopy KW - Metabolites KW - Herbicides KW - Pesticides KW - Acetochlor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40089525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Identification+of+a+Major+Human+Metabolite+of+Acetochlor+in+Exposed+Herbicide+Applicators+by+High+Performance+Liquid+Chromatography-Tandem+Mass+Spectrometry&rft.au=Hines%2C+C%3BStriley%2C+C%3BBarr%2C+D%3BOlsson%2C+A%3BBravo%2C+R%3BNorrgran%2C+J%3BNeedham%2C+L%3BDeddens%2C+J&rft.aulast=Hines&rft.aufirst=C&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Guidance for the Evaluation of Direct-Reading Gas and Vapor Monitors T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069745; 4241617 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Kennedy, E AU - Woebkenberg, M AU - Schlecht, P AU - Bartley, D AU - Shulman, S AU - Feng, H AU - Song, R AU - Cowherd, C AU - Grelinger, M AU - Bauer, K Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Vapors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Guidance+for+the+Evaluation+of+Direct-Reading+Gas+and+Vapor+Monitors&rft.au=Kennedy%2C+E%3BWoebkenberg%2C+M%3BSchlecht%2C+P%3BBartley%2C+D%3BShulman%2C+S%3BFeng%2C+H%3BSong%2C+R%3BCowherd%2C+C%3BGrelinger%2C+M%3BBauer%2C+K&rft.aulast=Kennedy&rft.aufirst=E&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Respirable Dust Exposures of Workers Using an Improved Clothes Cleaning Process T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069649; 4241602 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Cecala, A AU - Pollock, D AU - O'Brien, A AU - Howell, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Cleaning process KW - Dust KW - Occupational exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Reducing+Respirable+Dust+Exposures+of+Workers+Using+an+Improved+Clothes+Cleaning+Process&rft.au=Cecala%2C+A%3BPollock%2C+D%3BO%27Brien%2C+A%3BHowell%2C+J&rft.aulast=Cecala&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suspension Tolerance in Men and Women Wearing Safety Harnesses T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069306; 4241601 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Turner, N AU - Weaver, D AU - Whisler, R AU - Zwiener, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Suspension UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Suspension+Tolerance+in+Men+and+Women+Wearing+Safety+Harnesses&rft.au=Turner%2C+N%3BWeaver%2C+D%3BWhisler%2C+R%3BZwiener%2C+J&rft.aulast=Turner&rft.aufirst=N&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respirator Use and Practices by National Demolition Association Member Companies T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40068433; 4241734 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Doney, B AU - Greskevitch, M AU - Groce, D Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40068433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Respirator+Use+and+Practices+by+National+Demolition+Association+Member+Companies&rft.au=Doney%2C+B%3BGreskevitch%2C+M%3BGroce%2C+D&rft.aulast=Doney&rft.aufirst=B&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissolution of Finely Divided Single-Constituent and Multi-Constituent Beryllium Aerosol Materials Associated with Beryllium Sensitization and Chronic Beryllium Disease T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40068220; 4241682 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Stefaniak, A AU - Hoover, M AU - Day, G AU - Breysse, P AU - Scripsick, R Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Beryllium KW - Aerosols KW - Berylliosis KW - Dissolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40068220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Dissolution+of+Finely+Divided+Single-Constituent+and+Multi-Constituent+Beryllium+Aerosol+Materials+Associated+with+Beryllium+Sensitization+and+Chronic+Beryllium+Disease&rft.au=Stefaniak%2C+A%3BHoover%2C+M%3BDay%2C+G%3BBreysse%2C+P%3BScripsick%2C+R&rft.aulast=Stefaniak&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Questionnaire Modes and Distribution Methods in a Large Medical Center -- Results of a Pilot Test T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40060355; 4241719 DE: JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Boiano, J AU - Piacitelli, G AU - Sieber, K AU - Catalano, J AU - Heyer, N AU - Payne, B Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Questionnaire+Modes+and+Distribution+Methods+in+a+Large+Medical+Center+--+Results+of+a+Pilot+Test&rft.au=Boiano%2C+J%3BPiacitelli%2C+G%3BSieber%2C+K%3BCatalano%2C+J%3BHeyer%2C+N%3BPayne%2C+B&rft.aulast=Boiano&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineering Controls for Cutting Concrete Tiles T2 - 8th International Conference on Ventilation (VENT 2006) AN - 40059488; 4241429 JF - 8th International Conference on Ventilation (VENT 2006) AU - Sheehy, J AU - Echt, A AU - Garcia, A Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Concrete UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40059488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.atitle=Engineering+Controls+for+Cutting+Concrete+Tiles&rft.au=Sheehy%2C+J%3BEcht%2C+A%3BGarcia%2C+A&rft.aulast=Sheehy&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/aihce06/vent-sessions-ataglance.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of X-Ray Fluorescence and Wet Chemical Analysis of Air Filter Samples from a Lead/Zinc/Silver Ore Concentrator Mill T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40021264; 4241637 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Harper, M AU - Pacolay, B AU - Hintz, P AU - Andrew, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Pollutant removal KW - Zinc KW - Chemical analysis KW - Silver KW - Fluorescence KW - Air purification KW - Lead KW - Filters KW - Heavy metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+Comparison+of+X-Ray+Fluorescence+and+Wet+Chemical+Analysis+of+Air+Filter+Samples+from+a+Lead%2FZinc%2FSilver+Ore+Concentrator+Mill&rft.au=Harper%2C+M%3BPacolay%2C+B%3BHintz%2C+P%3BAndrew%2C+M&rft.aulast=Harper&rft.aufirst=M&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of Fecal Contamination Within a Machine at a Manufacturing Site T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40021090; 4241643 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Ewers, L AU - Tapp, L AU - Achutan, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evidence+of+Fecal+Contamination+Within+a+Machine+at+a+Manufacturing+Site&rft.au=Ewers%2C+L%3BTapp%2C+L%3BAchutan%2C+C&rft.aulast=Ewers&rft.aufirst=L&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Respirator Fit Test Panel Based on Principal Component Analysis T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40020874; 4241499 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Zhuang, Z AU - Shaffer, R AU - Bradtmiller, B Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Principal components analysis KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+New+Respirator+Fit+Test+Panel+Based+on+Principal+Component+Analysis&rft.au=Zhuang%2C+Z%3BShaffer%2C+R%3BBradtmiller%2C+B&rft.aulast=Zhuang&rft.aufirst=Z&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIOSH Health Hazard Evaluation of a Cultured Marble Manufacturing Facility T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019991; 4241721 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - McCleery, R AU - Tubbs, R AU - Warren, A Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Marble KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=NIOSH+Health+Hazard+Evaluation+of+a+Cultured+Marble+Manufacturing+Facility&rft.au=McCleery%2C+R%3BTubbs%2C+R%3BWarren%2C+A&rft.aulast=McCleery&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Proposed Ventilation Equations for Exothermic Process Control T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019942; 4241693 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - McKernan, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Ventilation KW - Mathematical models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Proposed+Ventilation+Equations+for+Exothermic+Process+Control&rft.au=McKernan%2C+J&rft.aulast=McKernan&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Storage Conditions on Recovering Culturable Fungi from Dust Samples T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019854; 4241701 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Park, J AU - Pearce, T AU - Cox-Ganser, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Dust KW - Fungi KW - Airborne microorganisms KW - Storage KW - Storage conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Effects+of+Storage+Conditions+on+Recovering+Culturable+Fungi+from+Dust+Samples&rft.au=Park%2C+J%3BPearce%2C+T%3BCox-Ganser%2C+J&rft.aulast=Park&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laboratory Evaluation to Reduce Respirable Crystalline Silica Dust when Cutting Cement Roofing Tiles Using a Masonry Saw T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40004021; 4241603 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Valladares, R AU - Sieber, W AU - Kratzer, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Dust KW - Silica KW - Cement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Laboratory+Evaluation+to+Reduce+Respirable+Crystalline+Silica+Dust+when+Cutting+Cement+Roofing+Tiles+Using+a+Masonry+Saw&rft.au=Valladares%2C+R%3BSieber%2C+W%3BKratzer%2C+J&rft.aulast=Valladares&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of X-Ray Fluorescence and Wet Chemical Analysis of Air Filter Samples From a Lead-Acid Battery Recycling Plant (Secondary Lead Smelter) T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 39965373; 4241539 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Hintz, P AU - Harper, M AU - Pacolay, B AU - Andrew, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Pollutant removal KW - Chemical analysis KW - Waste management KW - Recycling KW - Fluorescence KW - Smelters KW - Batteries KW - Air purification KW - Mining KW - Lead KW - Filters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39965373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+Comparison+of+X-Ray+Fluorescence+and+Wet+Chemical+Analysis+of+Air+Filter+Samples+From+a+Lead-Acid+Battery+Recycling+Plant+%28Secondary+Lead+Smelter%29&rft.au=Hintz%2C+P%3BHarper%2C+M%3BPacolay%2C+B%3BAndrew%2C+M&rft.aulast=Hintz&rft.aufirst=P&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lower Extremity Balance Demand for Construction Workers on Stilts T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 39965137; 4241489 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Chiou, S AU - Pan, C AU - Zwiener, J AU - Cantis, D AU - Ronaghi, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Construction industry KW - Extremities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39965137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Lower+Extremity+Balance+Demand+for+Construction+Workers+on+Stilts&rft.au=Chiou%2C+S%3BPan%2C+C%3BZwiener%2C+J%3BCantis%2C+D%3BRonaghi%2C+M&rft.aulast=Chiou&rft.aufirst=S&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-Strand DNA Breaks Associated with Class Switch Recombination T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39245752; 4229159 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Arudchandran, Arulvathani AU - Bernstein, Ralph AU - Max, Edward Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - DNA KW - Recombination KW - Class switching KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39245752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Single-Strand+DNA+Breaks+Associated+with+Class+Switch+Recombination&rft.au=Arudchandran%2C+Arulvathani%3BBernstein%2C+Ralph%3BMax%2C+Edward&rft.aulast=Arudchandran&rft.aufirst=Arulvathani&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Statins, Inhibitors of HmG CoA Reductase, Directly Affect Morphology and Migration of Activated CD4 T Lymphocytes. T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39191531; 4228504 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Arora, Kamalpreet AU - Chen, Trina AU - Hill, Chris AU - Kozlowski, Steven AU - Reischl, Ilona Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes KW - Morphology KW - Hydroxymethylglutaryl-CoA reductase KW - Lymphocytes T KW - CD4 antigen KW - Cell migration KW - Statins KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39191531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Statins%2C+Inhibitors+of+HmG+CoA+Reductase%2C+Directly+Affect+Morphology+and+Migration+of+Activated+CD4+T+Lymphocytes.&rft.au=Arora%2C+Kamalpreet%3BChen%2C+Trina%3BHill%2C+Chris%3BKozlowski%2C+Steven%3BReischl%2C+Ilona&rft.aulast=Arora&rft.aufirst=Kamalpreet&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Double-Stranded RNA-Induced Type I IFN Induces Immunoproteasomes during Viral Infection T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39191427; 4229470 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Feinstone, Stephen AU - Kloetzel, Peter-M AU - Rehermann, Barbara AU - Rice, Charles AU - Seifert, Ulrike AU - Cheol, EuiShin Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Infection KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39191427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Double-Stranded+RNA-Induced+Type+I+IFN+Induces+Immunoproteasomes+during+Viral+Infection&rft.au=Feinstone%2C+Stephen%3BKloetzel%2C+Peter-M%3BRehermann%2C+Barbara%3BRice%2C+Charles%3BSeifert%2C+Ulrike%3BCheol%2C+EuiShin&rft.aulast=Feinstone&rft.aufirst=Stephen&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biota-Bound Cyanobacterial Hepatotoxins in Lakes Surrounding the City of Riga, Latvia, and in Southern Gulf of Riga (the Baltic Sea) T2 - 16th Europe Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC 2006) AN - 39206263; 4217792 JF - 16th Europe Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC 2006) AU - Balode, M AU - Kankaanpaa, H AU - Purina, A AU - Olin, M AU - Sjovall, O AU - Bumane, D AU - Barda, I AU - Meriluoto, J Y1 - 2006/05/07/ PY - 2006 DA - 2006 May 07 KW - Baltic Sea, Riga Gulf KW - Latvia KW - Urban areas KW - Lakes KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39206263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Europe+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2006%29&rft.atitle=Biota-Bound+Cyanobacterial+Hepatotoxins+in+Lakes+Surrounding+the+City+of+Riga%2C+Latvia%2C+and+in+Southern+Gulf+of+Riga+%28the+Baltic+Sea%29&rft.au=Balode%2C+M%3BKankaanpaa%2C+H%3BPurina%2C+A%3BOlin%2C+M%3BSjovall%2C+O%3BBumane%2C+D%3BBarda%2C+I%3BMeriluoto%2C+J&rft.aulast=Balode&rft.aufirst=M&rft.date=2006-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Europe+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/welcome.do?type=public&congress =44_AM06 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real Time Measurement of Heating Near Metallic Implants Throughout a Phantom using Phase-Shift MR Thermometry T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40021137; 4243391 DE: JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bassen, Howard AU - Kam, Anthony AU - Kainz, Wolfgang AU - Mendoza, Gonzalo AU - Wang, Honghui Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Real+Time+Measurement+of+Heating+Near+Metallic+Implants+Throughout+a+Phantom+using+Phase-Shift+MR+Thermometry&rft.au=Bassen%2C+Howard%3BKam%2C+Anthony%3BKainz%2C+Wolfgang%3BMendoza%2C+Gonzalo%3BWang%2C+Honghui&rft.aulast=Bassen&rft.aufirst=Howard&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficient, Robust, Nonlinear, and Guaranteed Positive Definite Diffusion Tensor Estimation T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39992677; 4242560 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Cox, Robert W AU - Glen, Daniel Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Efficient%2C+Robust%2C+Nonlinear%2C+and+Guaranteed+Positive+Definite+Diffusion+Tensor+Estimation&rft.au=Cox%2C+Robert+W%3BGlen%2C+Daniel&rft.aulast=Cox&rft.aufirst=Robert&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Determination of 17alpha-methyltestosterone in muscle tissues of tilapia, rainbow trout, and salmon using liquid chromatography-tandem mass spectrometry. AN - 67901422; 16637671 AB - An analytical method was developed to quantitate and confirm the presence of 17alpha-methyltestosterone in the muscles of tilapia, rainbow trout, and salmon. The method employed two liquid-liquid partitioning steps and two solid-phase extraction columns for sample cleanup. The final extracts were analyzed on an isocratic reverse-phase liquid chromatography-tandem mass spectrometry system with atmospheric-pressure chemical ionization in the positive ion mode. The method was validated at levels from 0.40 to 1.6 ng/g, with MT-d3 used as an internal standard. The accuracy was between 100% and 110%, and coefficients of variation of <10% were obtained for all three fish species. Muscle tissues from dosed fish were also assayed to demonstrate the effectiveness of the method for recovering the parent drug. JF - Journal of agricultural and food chemistry AU - Chu, Pak-Sin AU - Lopez, Mayda AU - Serfling, Stan AU - Gieseker, Charlie AU - Reimschuessel, Renate AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA. Pak.Chu@FDA.GOV Y1 - 2006/05/03/ PY - 2006 DA - 2006 May 03 SP - 3193 EP - 3198 VL - 54 IS - 9 SN - 0021-8561, 0021-8561 KW - Methyltestosterone KW - V9EFU16ZIF KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Food Contamination -- analysis KW - Salmon KW - Muscles -- chemistry KW - Chromatography, Liquid -- methods KW - Mass Spectrometry -- methods KW - Oncorhynchus mykiss KW - Methyltestosterone -- analysis KW - Tilapia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67901422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+17alpha-methyltestosterone+in+muscle+tissues+of+tilapia%2C+rainbow+trout%2C+and+salmon+using+liquid+chromatography-tandem+mass+spectrometry.&rft.au=Chu%2C+Pak-Sin%3BLopez%2C+Mayda%3BSerfling%2C+Stan%3BGieseker%2C+Charlie%3BReimschuessel%2C+Renate&rft.aulast=Chu&rft.aufirst=Pak-Sin&rft.date=2006-05-03&rft.volume=54&rft.issue=9&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-20 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Preaching or Teaching: The Power of Stories to Change Worker Behavior T2 - 8th World Conference on Injury Prevention and Safety Promotion AN - 40064677; 4250715 JF - 8th World Conference on Injury Prevention and Safety Promotion AU - Cullen, E Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 KW - Education KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40064677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.atitle=Preaching+or+Teaching%3A+The+Power+of+Stories+to+Change+Worker+Behavior&rft.au=Cullen%2C+E&rft.aulast=Cullen&rft.aufirst=E&rft.date=2006-05-02&rft.volume=&rf