TY - CPAPER T1 - Confirmation and Quantitation of Peanut Allergens in Foods by Mass Spectrometry T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39226801; 4354826 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Musser, Steven M AU - Shefcheck, Kevin J AU - Callahan, John H Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Mass spectroscopy KW - Allergens KW - Food KW - Nuts KW - Quantitation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39226801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Confirmation+and+Quantitation+of+Peanut+Allergens+in+Foods+by+Mass+Spectrometry&rft.au=Musser%2C+Steven+M%3BShefcheck%2C+Kevin+J%3BCallahan%2C+John+H&rft.aulast=Musser&rft.aufirst=Steven&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Mycotoxins in Botanical Roots and Finished Products T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39207909; 4354925 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Trucksess, Mary W AU - Weaver, Carol M AU - Oles, Carolyn J AU - Rader, Jeanne I Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Mycotoxins KW - Roots KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39207909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Determination+of+Mycotoxins+in+Botanical+Roots+and+Finished+Products&rft.au=Trucksess%2C+Mary+W%3BWeaver%2C+Carol+M%3BOles%2C+Carolyn+J%3BRader%2C+Jeanne+I&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Allergens: Methods of Detection and the Importance of Validation T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39174597; 4354820 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Garber, Eric A.E. Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Allergens KW - Food hypersensitivity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39174597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Food+Allergens%3A+Methods+of+Detection+and+the+Importance+of+Validation&rft.au=Garber%2C+Eric+A.E.&rft.aulast=Garber&rft.aufirst=Eric&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The US Orphan Drug Act: Benefits to Patients, Benefits to Community T2 - Second Eastern European Conference on Rare Diseases and Orphan Drugs AN - 40409429; 4449181 JF - Second Eastern European Conference on Rare Diseases and Orphan Drugs AU - Haffner, Marlene E Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40409429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Eastern+European+Conference+on+Rare+Diseases+and+Orphan+Drugs&rft.atitle=The+US+Orphan+Drug+Act%3A+Benefits+to+Patients%2C+Benefits+to+Community&rft.au=Haffner%2C+Marlene+E&rft.aulast=Haffner&rft.aufirst=Marlene&rft.date=2006-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Eastern+European+Conference+on+Rare+Diseases+and+Orphan+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.conf2006.raredis.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gender and Age Differences in Posttraumatic Stress Disorder and Depression Among Buffalo Police Officers AN - 877591961; 13617252 AB - Because of the stressful nature of police work, officers may be at increased risk for posttraumatic stress disorder (PTSD) and depression. The Impact of Event Scale (IES) and Center for Epidemiologic Studies-Depression (CES-D) survey were administered to 100 officers. Mean IES and CES-D scores and prevalence of PTSD and depression were compared across gender and age. Female officers had higher mean IES and CES-D scores than male officers. Mean CES-D scores tended to increase with age, whereas mean IES scores varied little across age. Prevalence of depression was greater among women (22.0%) than men (12.1%), yet differences were less evident for PTSD (36.6% women, 34.5% men). Depression and PTSD tended to increase with age and were not explained by gender, marital status, or education. JF - Traumatology AU - Darensburg, Tahera AU - Andrew, Michael E AU - Hartley, Tara A AU - Burchfiel, Cecil M AU - Fekedulegn, Desta AU - Violanti, John M AD - Rollins School of Public Health, Emory University; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, cburchfiel@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 220 EP - 228 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 3 SN - 1534-7656, 1534-7656 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877591961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Gender+and+Age+Differences+in+Posttraumatic+Stress+Disorder+and+Depression+Among+Buffalo+Police+Officers&rft.au=Darensburg%2C+Tahera%3BAndrew%2C+Michael+E%3BHartley%2C+Tara+A%3BBurchfiel%2C+Cecil+M%3BFekedulegn%2C+Desta%3BViolanti%2C+John+M&rft.aulast=Darensburg&rft.aufirst=Tahera&rft.date=2006-09-01&rft.volume=12&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765606296271 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/1534765606296271 ER - TY - JOUR T1 - Unrestrained Acoustic Plethysmograph for Measuring Tidal Volume in Mice AN - 831174421; 13866787 AB - The traditional method for measurement of tidal volume in unrestrained mice relies on pressure changes induced by a freely respiring animal in a whole body plethysmograph. These changes have been assumed to be the result of thermo-hygrometric differences between respired air and gas within the chamber. It is known, however, that gas compression in the lung can also contribute significantly to changes in plethysmograph pressure. This study describes an acoustic plethysmograph for mice that is capable of measuring the tidal volume time series without the errors associated with the traditional method. The plethysmograph was designed as a resonating cavity at a fixed frequency. It had a sharp resonant peak and was tuned so that changes in body volume produced nearly linear changes in sound amplitude. The plethysmograph was tested with a water filled balloon connected to a syringe pump. The volume of the balloon was varied as a triangle wave with an amplitude of 250kL. The RMS error between measured and delivered volume was 4.43kL. A volume step test, performed to assess the response time of the system, showed that the plethysmograph responded in less than one millisecond. JF - Annals of Biomedical Engineering AU - Reynolds, Jeffrey S AU - Frazer, David G AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, jsr0@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1494 EP - 1499 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 34 IS - 9 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Cavities KW - Acoustics KW - Lung KW - Sound KW - Syringes KW - Waves KW - Pressure KW - Balloons KW - Compression KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831174421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Unrestrained+Acoustic+Plethysmograph+for+Measuring+Tidal+Volume+in+Mice&rft.au=Reynolds%2C+Jeffrey+S%3BFrazer%2C+David+G&rft.aulast=Reynolds&rft.aufirst=Jeffrey&rft.date=2006-09-01&rft.volume=34&rft.issue=9&rft.spage=1494&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-006-9159-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Cavities; Lung; Acoustics; Sound; Syringes; Waves; Pressure; Compression; Balloons DO - http://dx.doi.org/10.1007/s10439-006-9159-8 ER - TY - JOUR T1 - Single-laboratory validation of a method for the determination of furan in foods by using static headspace sampling and gas chromatography/mass spectrometry. AN - 68963501; 17042194 AB - A headspace gas chromatography/mass spectrometry method was developed and validated in-house for the determination of furan in foods. The method of standard additions with d4-furan as the internal standard was used to quantitate furan. The limit of detection and limit of quantitation (LOQ) values ranged from 0.2 and 0.6 nglg, respectively, in apple juice to 0.9 and 2.9 ng/g, respectively, in peanut butter. Recoveries were obtained at 0.5, 1, 2, and 3 times the LOQ. At 1, 2, and 3 times the LOQ, the recoveries ranged from 89.4 to 108%, and the relative standard deviations ranged from 3.3 to 17.3% for all the matrixes. For apple juice, chicken broth, and infant formula, the averaged coefficients of determination from the linear regression analyses were >0.99 with each food fortified at 0.5, 1, 2, and 3 times the LOQ. The coefficients of determination were >0.99 for green beans and 0.96 for peanut butter with the foods fortified at 1, 2, and 3 times the LOQ. Within-laboratory precision was determined by comparing the amounts of furan found in 18 samples by 2 analysts on different days with different instruments. For most of the foods, the difference between the amounts found by each analyst was 300 foods. The furan levels found ranged from none detected to 174 ng/g. JF - Journal of AOAC International AU - Nyman, Patricia J AU - Morehouse, Kim M AU - McNeal, Timothy P AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. patricia.nyman@fda.hhs.gov PY - 2006 SP - 1417 EP - 1424 VL - 89 IS - 5 SN - 1060-3271, 1060-3271 KW - Carcinogens KW - 0 KW - Furans KW - Index Medicus KW - Reproducibility of Results KW - Carcinogens -- standards KW - Reference Standards KW - Carcinogens -- analysis KW - Food Analysis -- statistics & numerical data KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Furans -- standards KW - Food Contamination -- statistics & numerical data KW - Food Contamination -- analysis KW - Gas Chromatography-Mass Spectrometry -- statistics & numerical data KW - Gas Chromatography-Mass Spectrometry -- standards KW - Furans -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68963501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Single-laboratory+validation+of+a+method+for+the+determination+of+furan+in+foods+by+using+static+headspace+sampling+and+gas+chromatography%2Fmass+spectrometry.&rft.au=Nyman%2C+Patricia+J%3BMorehouse%2C+Kim+M%3BMcNeal%2C+Timothy+P%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Two rapid methods for detection of Escherichia coli exceeding 10(4)/g action levels: precollaborative study. AN - 68963318; 17042182 AB - The current AOAC Method 966.24 for enumeration of Escherichia coli in foods uses a most probable number (MPN) procedure with extensive confirmation steps. Two new methods based on membrane filtration (MF) were compared to the MPN reference method for detection of high levels of E. coli in 5 food types, some of which represent categories for which the U.S. Food and Drug Administration (FDA) mandates additional testing if an action level of 10(4)/g E. coli is exceeded. Ground beef, which is not FDA regulated, was also tested. The 5 food types were all inoculated at 3 levels: 10(2)/g, > or = 10(4)/g, and > or = 10(5)/g E. coli. An MF protocol using either m-ColiBlue24 (CB) or lauryl sulfate tryptose plus BCIG (LST/BCIG) was an effective potential alternative to the reference method. Sensitivity and specificity for both CB and LST/BCIG were 98 and 100%, respectively. Agreement between MPN and both CB and LST/BCIG was 98%. The 2 proposed methods allow completion of both presumptive and confirmatory steps in 1-3 days, whereas the reference method requires as many as 11 days. Exclusivity testing with 50 non-E. coli strains indicated 100% were correctly ruled out by the proposed protocols. Inclusivity testing was used to determine whether typical results were obtained after incubation of E. coli cultures on CB or LST/BCIG for 24 h. Of 50 E. coli strains tested, 100% yielded typical results after incubation on CB, and 98% yielded typical results after incubation on LST/BCIG. JF - Journal of AOAC International AU - Grant, Michael A AU - Wernberg, Jane S AU - Van, Khanh T AU - Albert, Angelina M AD - U.S. Food and Drug Administration, Pacific Regional Laboratory, Northwest, Bothell, WA 98021, USA. mike.grant@fda.hhs.gov PY - 2006 SP - 1317 EP - 1326 VL - 89 IS - 5 SN - 1060-3271, 1060-3271 KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Filtration -- methods KW - Cooperative Behavior KW - United States Food and Drug Administration KW - Time Factors KW - Food Microbiology -- standards KW - Colony Count, Microbial -- methods KW - Escherichia coli -- isolation & purification KW - Colony Count, Microbial -- statistics & numerical data KW - Colony Count, Microbial -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68963318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Two+rapid+methods+for+detection+of+Escherichia+coli+exceeding+10%284%29%2Fg+action+levels%3A+precollaborative+study.&rft.au=Grant%2C+Michael+A%3BWernberg%2C+Jane+S%3BVan%2C+Khanh+T%3BAlbert%2C+Angelina+M&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial personality disorder with childhood- vs. adolescence-onset conduct disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68851074; 16971818 AB - This study, based on a nationally representative, epidemiologic sample (N = 43,093, response rate 81%), compared sociodemographic and family history correlates, antisocial personality disorder (ASPD) symptom patterns, and Axis I and Axis II comorbidity, among adults with DSM-IV ASPD who reported onset of conduct disorder (CD) in childhood ( or =age 10). Prevalence of each ASPD diagnostic criterion and comorbid lifetime disorder was estimated. Logistic regression was used to examine associations of childhood-onset CD with ASPD symptom patterns and comorbid disorders. Among the 1422 respondents with ASPD, 447 reported childhood-onset CD. Childhood-onset respondents were more likely than adolescence-onset respondents to endorse CD criteria involving aggression against persons, animals, and property before age 15, and to endorse more childhood criteria and lifetime violent behaviors. Childhood-onset respondents displayed significantly elevated odds of lifetime social phobia, generalized anxiety disorder, drug dependence, and paranoid, schizoid, and avoidant personality disorders, but significantly decreased odds for lifetime tobacco dependence. Childhood-onset CD appears to identify a more polysymptomatic and violent form of ASPD, associated with greater lifetime comorbidity for selected Axis I and Axis II disorders, in nonclinical populations. JF - The Journal of nervous and mental disease AU - Goldstein, Risë B AU - Grant, Bridget F AU - Ruan, W June AU - Smith, Sharon M AU - Saha, Tulshi D AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 667 EP - 675 VL - 194 IS - 9 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Violence -- statistics & numerical data KW - Age of Onset KW - Mental Disorders -- epidemiology KW - Humans KW - Mental Disorders -- psychology KW - Child KW - Comorbidity KW - Cross-Sectional Studies KW - Mental Disorders -- diagnosis KW - Logistic Models KW - Adult KW - Health Surveys KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Violence -- psychology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Alcohol-Related Disorders -- epidemiology KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Conduct Disorder -- epidemiology KW - Conduct Disorder -- psychology KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68851074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Antisocial+personality+disorder+with+childhood-+vs.+adolescence-onset+conduct+disorder%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F%3BRuan%2C+W+June%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2006-09-01&rft.volume=194&rft.issue=9&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-13 N1 - Date created - 2006-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Nerv Ment Dis. 2008 Mar;196(3):263 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transformation of the antibacterial agent norfloxacin by environmental mycobacteria. AN - 68837059; 16957195 AB - Because fluoroquinolone antimicrobial agents may be released into the environment, the potential for environmental bacteria to biotransform these drugs was investigated. Eight Mycobacterium sp. cultures in a sorbitol-yeast extract medium were dosed with 100 microg ml(-1) of norfloxacin and incubated for 7 days. The MICs of norfloxacin for these strains, tested by an agar dilution method, were 1.6 to 25 microg ml(-1). Cultures were extracted with ethyl acetate, and potential metabolites in the extracts were purified by high-performance liquid chromatography. The metabolites were identified using mass spectrometry and nuclear magnetic resonance spectroscopy. N-Acetylnorfloxacin (5 to 50% of the total absorbance at 280 nm) was produced by the eight Mycobacterium strains. N-Nitrosonorfloxacin (5 to 30% of the total absorbance) was also produced by Mycobacterium sp. strain PYR100 and Mycobacterium gilvum PYR-GCK. The MICs of N-nitrosonorfloxacin and N-acetylnorfloxacin were 2- to 38- and 4- to 1,000-fold higher, respectively, than those of norfloxacin for several different bacteria, including the two strains that produced both metabolites. Although N-nitrosonorfloxacin had less antibacterial activity, nitrosamines are potentially carcinogenic. The biotransformation of fluoroquinolones by mycobacteria may serve as a resistance mechanism. JF - Applied and environmental microbiology AU - Adjei, Michael D AU - Heinze, Thomas M AU - Deck, Joanna AU - Freeman, James P AU - Williams, Anna J AU - Sutherland, John B AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5790 EP - 5793 VL - 72 IS - 9 SN - 0099-2240, 0099-2240 KW - Anti-Bacterial Agents KW - 0 KW - Environmental Pollutants KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Environmental Pollutants -- metabolism KW - Biotransformation KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Environmental Microbiology KW - Anti-Bacterial Agents -- metabolism KW - Norfloxacin -- pharmacology KW - Mycobacterium -- drug effects KW - Anti-Bacterial Agents -- chemistry KW - Mycobacterium -- metabolism KW - Mycobacterium -- isolation & purification KW - Anti-Bacterial Agents -- pharmacology KW - Norfloxacin -- metabolism KW - Norfloxacin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68837059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Transformation+of+the+antibacterial+agent+norfloxacin+by+environmental+mycobacteria.&rft.au=Adjei%2C+Michael+D%3BHeinze%2C+Thomas+M%3BDeck%2C+Joanna%3BFreeman%2C+James+P%3BWilliams%2C+Anna+J%3BSutherland%2C+John+B&rft.aulast=Adjei&rft.aufirst=Michael&rft.date=2006-09-01&rft.volume=72&rft.issue=9&rft.spage=5790&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-09-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Ind Microbiol Biotechnol. 2001 Mar;26(3):140-4 [11420653] Nat Med. 2006 Jan;12(1):83-8 [16369542] Int J Syst Evol Microbiol. 2001 Sep;51(Pt 5):1715-22 [11594601] J Antimicrob Chemother. 2001 Dec;48(6):895-901 [11733475] Vet Res Commun. 2001 Dec;25(8):641-9 [11767010] Arch Biochem Biophys. 2003 Aug 15;416(2):209-17 [12893299] J Agric Food Chem. 2004 Jun 2;52(11):3473-7 [15161218] Nat Rev Microbiol. 2004 Jul;2(7):593-602 [15197394] Antimicrob Agents Chemother. 2004 Jul;48(7):2415-23 [15215089] Appl Environ Microbiol. 2004 Oct;70(10):6005-11 [15466544] Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 May 20;89(1):69-73 [141802] J Pharm Sci. 1984 Jan;73(1):99-102 [6229625] Eur J Clin Microbiol. 1987 Oct;6(5):584-6 [3125050] J Gen Microbiol. 1988 Jan;134(1):221-6 [3141563] Appl Environ Microbiol. 1988 Oct;54(10):2549-55 [3202633] Anal Chem. 2001 Aug 1;73(15):3632-8 [11510827] Mol Microbiol. 1990 Nov;4(11):1911-9 [2082148] Appl Environ Microbiol. 1993 Jun;59(6):1927-30 [8328808] Antimicrob Agents Chemother. 1994 Apr;38(4):773-80 [8031045] Appl Environ Microbiol. 1996 Jan;62(1):13-9 [8572690] Carcinogenesis. 1996 Mar;17(3):533-6 [8631140] Appl Microbiol Biotechnol. 1996 Oct;46(3):307-12 [8933844] Carcinogenesis. 1997 Feb;18(2):383-9 [9054633] Appl Environ Microbiol. 1997 Nov;63(11):4272-81 [9361414] J Ind Microbiol Biotechnol. 1997 Nov-Dec;19(5-6):378-84 [9451835] Antimicrob Agents Chemother. 1998 Apr;42(4):795-800 [9559785] Br Poult Sci. 1998 Mar;39(1):42-6 [9568297] J Bacteriol. 1999 Feb;181(4):1343-7 [9973365] Mutat Res. 1999 Jul 15;443(1-2):129-38 [10415436] FEMS Microbiol Lett. 1999 Aug 1;177(1):131-5 [10436931] J Control Release. 2005 Jan 3;101(1-3):343-5 [15838943] Adv Drug Deliv Rev. 2005 Jul 29;57(10):1451-70 [15950313] Microb Ecol. 2005 Jul;50(1):110-9 [16132428] Appl Microbiol Biotechnol. 2001 Aug;56(3-4):474-7 [11549022] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Waste incineration--how big is the health risk? A quantitative method to allow comparison with other health risks. AN - 68816874; 16868310 AB - To assess the health risk from a medium-sized waste incinerator and develop a single comparable figure to quantify overall risk. We used a prospective health risk assessment utilizing US Environmental Protection Agency Human Health Risk Assessment Protocol (HHRAP) for Hazardous Waste Combustion Facilities and UK coefficients for the impact of sulphur dioxide and particulates. Calculations were based on a resident population of 25,398 living within 5.5 km of the site. Anxiety, employment, noise, occupational risks, road accidents, and reduced use of landfill were all considered to have a potential, but unquantifiable, effect on health. Stack emissions over 25 years in a population of 25,398 within 5.5 km of the stack would result in an additional 0.018 cancers, 0.46 deaths brought forward due to sulphur dioxide and 0.02 deaths due to fine particles. The overall risk of dying due to emissions in any one year was 2.49 x 10(-7) or 1 in 4 million. To facilitate better public understanding of the comparative risk of incinerator emissions, we propose a simple method of deriving a single annual risk figure allowing comparison with the risk of dying from other causes with which the public is more familiar. JF - Journal of public health (Oxford, England) AU - Roberts, Richard J AU - Chen, Mengfang AD - National Public Health Service for Wales, Abton House, Wedal Road, Cardiff, CF14 3QX, UK. richard.roberts@nphs.wales.nhs.uk Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 261 EP - 266 VL - 28 IS - 3 SN - 1741-3842, 1741-3842 KW - Air Pollutants KW - 0 KW - Carcinogens KW - Dioxins KW - Hazardous Waste KW - Index Medicus KW - Humans KW - Carcinogens -- toxicity KW - Wales KW - Dioxins -- toxicity KW - Air Pollutants -- toxicity KW - Incineration KW - Hazardous Waste -- adverse effects KW - Air Pollution -- adverse effects KW - Environmental Exposure -- adverse effects KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+public+health+%28Oxford%2C+England%29&rft.atitle=Waste+incineration--how+big+is+the+health+risk%3F+A+quantitative+method+to+allow+comparison+with+other+health+risks.&rft.au=Roberts%2C+Richard+J%3BChen%2C+Mengfang&rft.aulast=Roberts&rft.aufirst=Richard&rft.date=2006-09-01&rft.volume=27&rft.issue=8&rft.spage=1713&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation. AN - 68769122; 16546258 AB - Serious questions have been raised regarding a possible causal association between neurological effects in welders and the presence of manganese in welding fume. An experimental model is needed that could examine the potential neurotoxic effect of manganese after pulmonary exposure to welding fume. The National Institute for Occupational Safety and Health (NIOSH) has recently finished construction of a completely automated, computer controlled welding fume generation and inhalation exposure system for laboratory animals. The system is comprised of a programmable six-axis robotic welding arm and a water-cooled arc welding torch. A flexible trunk has been attached to the robotic arm of the welder and is used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Preliminary fume characterization studies have indicated that particle morphology, size, and chemical composition were comparable to welding fume generated in the workplace. Animal inhalation studies are currently underway. With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system. JF - Neurotoxicology AU - Antonini, James M AU - O'Callaghan, James P AU - Miller, Diane B AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. jga6@cdc.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 745 EP - 751 VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Models, Animal KW - Neurotoxicity Syndromes -- etiology KW - Welding KW - Neurotoxicity Syndromes -- physiopathology KW - Air Pollutants, Occupational -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68769122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Development+of+an+animal+model+to+study+the+potential+neurotoxic+effects+associated+with+welding+fume+inhalation.&rft.au=Antonini%2C+James+M%3BO%27Callaghan%2C+James+P%3BMiller%2C+Diane+B&rft.aulast=Antonini&rft.aufirst=James&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analytical model for residual stresses in polymeric containers during cryogenic storage of hematopoietic stem cells. AN - 68734131; 16844438 AB - Hematopoietic stem cell (HSC) therapy can significantly lower instances of infection in chemotherapy patients by accelerating the recovery of white blood cells in the body. However, therapy requires that HSCs be stored at cryogenic temperatures to retain the cells' ability to proliferate. Currently, cells are stored in polymeric blood bags that are subject to fracture at the extremely low storage temperatures, which leads to cell contamination, thereby reducing their effectiveness. Therefore, we have developed an analytical model to predict the accumulation of stresses that ultimately lead to crack initiation and bag fracture during cryogenic storage. Our model gives explicit relationships between stress state in the container and thermoelastic properties of the container material, container geometry, and environmental factors that include temperature of the system and pressure induced by excess gas evolving from the stored medium. Predictions based on the model are consistent with experimental observations of bag failures that occurred during cryogenic storage applications. Finally, the model can provide guidance in material selection and bag design to fabricate bags that will be less susceptible to fracture. JF - Acta biomaterialia AU - Saylor, David M AU - McDermott, Martin K AU - Fuller, Edwin R AD - Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Rockville, MD 20852, USA. david.saylor@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 537 EP - 546 VL - 2 IS - 5 SN - 1742-7061, 1742-7061 KW - Antineoplastic Agents KW - 0 KW - Biocompatible Materials KW - Polymers KW - Index Medicus KW - Neoplasms -- drug therapy KW - Humans KW - Transplantation, Autologous KW - Neoplasms -- therapy KW - Antineoplastic Agents -- adverse effects KW - Equipment Design KW - Leukopenia -- chemically induced KW - Stress, Mechanical KW - In Vitro Techniques KW - Hematopoietic Stem Cell Transplantation KW - Materials Testing KW - Elasticity KW - Leukopenia -- therapy KW - Models, Theoretical KW - Cryopreservation -- instrumentation KW - Hematopoietic Stem Cells KW - Cryopreservation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68734131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+biomaterialia&rft.atitle=Analytical+model+for+residual+stresses+in+polymeric+containers+during+cryogenic+storage+of+hematopoietic+stem+cells.&rft.au=Saylor%2C+David+M%3BMcDermott%2C+Martin+K%3BFuller%2C+Edwin+R&rft.aulast=Saylor&rft.aufirst=David&rft.date=2006-09-01&rft.volume=2&rft.issue=5&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Acta+biomaterialia&rft.issn=17427061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-17 N1 - Date created - 2006-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. AN - 68721110; 16489464 AB - We performed a 28-day repeated-dose toxicity study of vinclozolin, a widely used fungicide, based on the draft protocol of the "Enhanced OECD Test Guideline 407" (Enhanced TG407) to investigate whether vinclozolin has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with vinclozolin daily by oral gavage at dose rates of 0, 3.125, 12.5, 50 and 200 mg/kg/day for at least 28 days. The vinclozolin-treated male rats showed a reduction of epididymis and accessory sex organ weights and an alteration of hormonal patterns. A slight prolongation of the estrous cycle and changes in the estrogen/testosterone ratio and luteinizing hormone level were observed in vinclozolin-treated female rats. Thyroxin concentrations were decreased and thyroid-stimulating hormone concentrations were increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of vinclozolin could be detected by the parameters examined in the present study based on the OECD protocol, suggesting the Enhanced TG407 protocol should be a suitable screening test for the detection of endocrine-mediated effects of chemicals. JF - Archives of toxicology AU - Shin, Jae-Ho AU - Moon, Hyun Ju AU - Kim, Tae Sung AU - Kang, Il Hyun AU - Ki, Ho Yeon AU - Choi, Kwang Sik AU - Han, Soon Young AD - Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Korea. jaehoshin@hanmir.com Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 547 EP - 554 VL - 80 IS - 9 SN - 0340-5761, 0340-5761 KW - Androgen Antagonists KW - 0 KW - Estrogens KW - Fungicides, Industrial KW - Oxazoles KW - Testosterone KW - 3XMK78S47O KW - Luteinizing Hormone KW - 9002-67-9 KW - Thyrotropin KW - 9002-71-5 KW - vinclozolin KW - JJ258EZN1I KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Thyrotropin -- blood KW - Dose-Response Relationship, Drug KW - Thyroxine -- blood KW - Estrous Cycle -- blood KW - Estrous Cycle -- drug effects KW - Estrogens -- blood KW - Rats KW - Rats, Sprague-Dawley KW - European Union KW - Testosterone -- blood KW - Guidelines as Topic KW - Luteinizing Hormone -- blood KW - Female KW - Male KW - Androgen Antagonists -- toxicity KW - Genitalia, Male -- drug effects KW - Genitalia, Male -- pathology KW - Toxicity Tests -- methods KW - Fungicides, Industrial -- toxicity KW - Oxazoles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68721110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Repeated+28-day+oral+toxicity+study+of+vinclozolin+in+rats+based+on+the+draft+protocol+for+the+%22Enhanced+OECD+Test+Guideline+No.+407%22+to+detect+endocrine+effects.&rft.au=Shin%2C+Jae-Ho%3BMoon%2C+Hyun+Ju%3BKim%2C+Tae+Sung%3BKang%2C+Il+Hyun%3BKi%2C+Ho+Yeon%3BChoi%2C+Kwang+Sik%3BHan%2C+Soon+Young&rft.aulast=Shin&rft.aufirst=Jae-Ho&rft.date=2006-09-01&rft.volume=80&rft.issue=9&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relation of body mass index to cancer risk in 362,552 Swedish men. AN - 68637311; 16841257 AB - Obesity has been linked with increased risk for cancers of the colon, kidney, breast, endometrium and gallbladder. For other cancer sites, the relationship with obesity is less well quantified, and the effect of weight change on cancer risk is unclear. We examined the health records of 362,552 Swedish men who underwent at least one physical examination from 1971 to 1992, and were followed until death or the end of 1999. Incident cancer cases were identified by linkage to the Swedish cancer registry. Poisson regression models were used to estimate relative risks of cancer for both body-mass index (BMI) at baseline exam and, in a subgroup of 107,815 men, change in BMI after six years of follow-up, adjusting for age and smoking status. Compared to men of normal weight, obese men had a significantly increased risk of all cancers combined (RR = 1.1; 95% CI = 1.0-1.2). The risks were most pronounced for esophageal adenocarcinoma (RR = 2.7; 95% CI = 1.3-5.6), renal cell carcinoma (RR = 1.8; 95% CI = 1.4-2.4), malignant melanoma (RR = 1.4; 95% CI = 1.1-1.7), and cancers of the colon (RR = 1.7; 95% CI = 1.5-2.0), rectum (RR = 1.4; 95% CI = 1.1-1.7), and liver (RR = 3.6; 95% CI = 2.6-5.0). Risk of esophageal squamous cell carcinoma was elevated for underweight men whose BMI was less than 18.5 (RR = 3.1; 95% CI = 1.1-8.3). An excess risk for cancers of the pancreas and connective tissue was observed only among nonsmokers. Compared to men whose weight remained stable, men with more than a 15% increase in BMI after six years of follow-up had an elevated risk of pancreas and renal cell cancers. Obesity and weight gain increase the risk for several forms of cancer in men, and underscore the need for further study into carcinogenic mechanisms and preventive interventions. JF - Cancer causes & control : CCC AU - Samanic, Claudine AU - Chow, Wong-Ho AU - Gridley, Gloria AU - Jarvholm, Bengt AU - Fraumeni, Joseph F AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Room 8115, Bethesda, MD 20892, USA. samanicc@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 901 EP - 909 VL - 17 IS - 7 SN - 0957-5243, 0957-5243 KW - Index Medicus KW - Waist-Hip Ratio KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Sweden -- epidemiology KW - Middle Aged KW - Follow-Up Studies KW - Weight Gain KW - Male KW - Obesity -- complications KW - Neoplasms -- epidemiology KW - Body Mass Index KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68637311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Volatile+organic+compounds+and+pulmonary+function+in+the+Third+National+Health+and+Nutrition+Examination+Survey%2C+1988-1994.&rft.au=Elliott%2C+Leslie%3BLongnecker%2C+Matthew+P%3BKissling%2C+Grace+E%3BLondon%2C+Stephanie+J&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung dosimetry and risk assessment of nanoparticles: evaluating and extending current models in rats and humans. AN - 68077629; 16774860 AB - Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment for species differences in the relationship between airborne exposure and internal dose. Another approach is lung dosimetry modeling, which provides a biologically-based, mechanistic method to extrapolate doses from animals to humans. However, current mass-based lung dosimetry models may not fully account for differences in the clearance and translocation of nanoparticles. In this article, key steps in quantitative risk assessment are illustrated, using dose-response data in rats chronically exposed to either fine or ultrafine titanium dioxide (TiO2), carbon black (CB), or diesel exhaust particulate (DEP). The rat-based estimates of the working lifetime airborne concentrations associated with 0.1% excess risk of lung cancer are approximately 0.07 to 0.3 mg/m3 for ultrafine TiO2, CB, or DEP, and 0.7 to 1.3 mg/m3 for fine TiO2. Comparison of observed versus model-predicted lung burdens in rats shows that the dosimetry models predict reasonably well the retained mass lung burdens of fine or ultrafine poorly soluble particles in rats exposed by chronic inhalation. Additional model validation is needed for nanoparticles of varying characteristics, as well as extension of these models to include particle translocation to organs beyond the lungs. Such analyses would provide improved prediction of nanoparticle dose for risk assessment. JF - Inhalation toxicology AU - Kuempel, E D AU - Tran, C L AU - Castranova, V AU - Bailer, A J AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. ekuempel@cdc.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 717 EP - 724 VL - 18 IS - 10 KW - Air Pollutants, Occupational KW - 0 KW - Soot KW - Vehicle Emissions KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Rats KW - Animals KW - Vehicle Emissions -- toxicity KW - Dose-Response Relationship, Drug KW - Humans KW - Species Specificity KW - Likelihood Functions KW - Risk Assessment KW - Titanium -- toxicity KW - Soot -- toxicity KW - Soot -- pharmacokinetics KW - Air Pollutants, Occupational -- toxicity KW - Lung -- metabolism KW - Soot -- chemistry KW - Air Pollutants, Occupational -- chemistry KW - Models, Biological KW - Nanoparticles KW - Lung Neoplasms -- etiology KW - Titanium -- chemistry KW - Lung -- drug effects KW - Air Pollutants, Occupational -- pharmacokinetics KW - Titanium -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68077629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+dosimetry+and+risk+assessment+of+nanoparticles%3A+evaluating+and+extending+current+models+in+rats+and+humans.&rft.au=Kuempel%2C+E+D%3BTran%2C+C+L%3BCastranova%2C+V%3BBailer%2C+A+J&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2006-09-01&rft.volume=18&rft.issue=10&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2006-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Inhal Toxicol. 2007 Feb;19(2):195; author reply 197-8 [17169866] N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - NIH News in Health: September 2006 AN - 62032145; ED495342 AB - News in Health, is a monthly newsletter that provides practical health news and information. As college students arrive on campus this fall, it is a time of new experiences, new friendships and making memories that will last a lifetime. Unfortunately for many, it can also be a time of excessive drinking and dealing with its aftermath--vandalism, violence, sexual aggression and even death. For those beginning their college experience, a rapid increase in heavy drinking over a relatively short period of time can cause serious problems with the transition to college. This period is also marked by taking risks. This can include risky drinking and early drinking is associated with other risky behavior, such as academic failure, unsafe sexual behavior and drug use. This issue contains the following articles: (1) Discussing Drinking: A Back-to-School Conversation You Need to Have; (2) Drugs are a Drag: Help Your Child Avoid Drugs of Abuse; (3) Stay Skeptical about Genetic Testing; (4) Get Active for a Healthy Heart; and (5) Web Site: College Drinking. AU - Wein, Harrison Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 4 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Higher Education KW - At Risk Persons KW - Alcohol Abuse KW - College Students KW - Definitions KW - Drug Education KW - Mental Health KW - Narcotics KW - Newsletters KW - Scholastic Journalism KW - Behavior Problems KW - Screening Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62032145?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Workplace Violence Prevention Strategies and Research Needs AN - 58753145; 2007-20606 AB - Since the 1980s, violence has been recognized as a leading cause of occupational mortality and morbidity. On average, 1.7 million workers are injured each year, and more than 800 die as a result of workplace violence (WPV). These tragic deaths and injuries stress the need for a proactive and collaborative WPV prevention effort at the national level. In November 2004, NIOSH organized a conference seeking a reduction in the toll of WPV. This report summarizes discussions that took place during the conference. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2006, 52 pp. AU - [Unknown] Y1 - 2006/09// PY - 2006 DA - September 2006 EP - 52p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Occupational health and safety KW - Workplace violence - Research KW - Workplace violence - Prevention KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58753145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=%5BUnknown%5D&rft.aulast=%5BUnknown%5D&rft.aufirst=&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=52p&rft.isbn=&rft.btitle=Workplace+Violence+Prevention+Strategies+and+Research+Needs&rft.title=Workplace+Violence+Prevention+Strategies+and+Research+Needs&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2006-144/pdfs/2006-144.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - DHHS (NIOSH) Publication No. 2006-144 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Ergonomics and Mining: Charting a Path to a Safer Workplace AN - 58751896; 2007-20605 AB - Ergonomics processes described in the literature have been associated mostly with manufacturing, financial, electronics, and office settings where working conditions tend to be rather constant and repetitive. The information presented in this document describes how Bridger Coal Company implemented an ergonomics process at its Jim Bridger Mine from 2001 through 2004. The process developed by the Ergonomics Committee, the promotion of the process to management and employees, and the impacts of the process on working conditions at the mine are reviewed. Barriers overcome and lessons learned are also described. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2006, 44 pp. AU - Gust, Paul AU - Johnson, Kean AU - Lewis, Pauline AU - Steiner, Lisa AU - Torma-Krajewski, Janet Y1 - 2006/09// PY - 2006 DA - September 2006 EP - 44p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Labor conditions and policy - Occupational health and safety KW - Mining industry - Safety measures KW - Human engineering - United States KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58751896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gust%2C+Paul%3BJohnson%2C+Kean%3BLewis%2C+Pauline%3BSteiner%2C+Lisa%3BTorma-Krajewski%2C+Janet&rft.aulast=Gust&rft.aufirst=Paul&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=44p&rft.isbn=&rft.btitle=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.title=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2006-141.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - NIOSH Publication No. 2006-141 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1 AN - 228355169; 16906159 AB - Receptor oligomerization is vital for activating intracellular signaling, in part by initiating events that recruit effector and adaptor proteins to sites of active signaling. Whether these distal molecules themselves oligomerize is not well appreciated. In this study, we examined the molecular interactions of the adaptor protein GRB2. In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL. Using biochemical and biophysical techniques in conjunction with confocal microscopy, we observed that the simultaneous association of GRB2, via its SH2 and SH3 domains, with multivalent ligands led to the oligomerization of these ligands, which affected signaling. These data suggest that multipoint binding of distal adaptor proteins mediates the formation of oligomeric signaling clusters vital for intracellular signaling. JF - Nature Structural & Molecular Biology AU - Houtman, Jon C D AU - Yamaguchi, Hiroshi AU - Barda-Saad, Mira AU - Braiman, Alex AU - Bowden, Brent AU - Appella, Ettore AU - Schuck, Peter AU - Samelson, Lawrence E Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 798 EP - 805 CY - New York PB - Nature Publishing Group VL - 13 IS - 9 SN - 15459993 KW - Biology KW - Adaptor Proteins, Signal Transducing KW - GRB2 Adaptor Protein KW - GRB2 protein, human KW - LAT protein, human KW - Ligands KW - Membrane Proteins KW - Phosphopeptides KW - Receptors, Antigen, T-Cell KW - SOS1 Protein KW - Proline KW - Molecular biology KW - Cellular biology KW - Signal transduction KW - Proteins KW - Binding sites KW - GRB2 Adaptor Protein -- chemistry KW - SOS1 Protein -- chemistry KW - Membrane Proteins -- chemistry KW - Humans KW - Receptors, Antigen, T-Cell -- metabolism KW - Jurkat Cells KW - Amino Acid Sequence KW - Models, Biological KW - Protein Binding KW - src Homology Domains KW - Adaptor Proteins, Signal Transducing -- chemistry KW - Phosphopeptides -- metabolism KW - Proline -- metabolism KW - Molecular Sequence Data KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Membrane Proteins -- metabolism KW - SOS1 Protein -- metabolism KW - Signal Transduction KW - Protein Structure, Quaternary KW - GRB2 Adaptor Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/228355169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=Oligomerization+of+signaling+complexes+by+the+multipoint+binding+of+GRB2+to+both+LAT+and+SOS1&rft.au=Houtman%2C+Jon+C+D%3BYamaguchi%2C+Hiroshi%3BBarda-Saad%2C+Mira%3BBraiman%2C+Alex%3BBowden%2C+Brent%3BAppella%2C+Ettore%3BSchuck%2C+Peter%3BSamelson%2C+Lawrence+E&rft.aulast=Houtman&rft.aufirst=Jon+C&rft.date=2006-09-01&rft.volume=13&rft.issue=9&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb1133 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Sep 2006 N1 - Last updated - 2014-04-29 DO - http://dx.doi.org/10.1038/nsmb1133 ER - TY - JOUR T1 - Toxicogenomics-A New Systems Toxicology Approach to Understanding of Gene-Environment Interactions AN - 20724169; 7220765 AB - Toxicogenomics is a new interdisciplinary area of research being developed to monitor the expression of multiple genes, proteins, and metabolites simultaneously. It combines new technologies in genomics, proteomics, and metabolomics with traditional tools of pathology and toxicology to study biological response to drugs and other environmental xenobiotics. The biological response to environmental exposure is so complex and involves so many interactive factors that the use of a systems biology analytical approach is required. In my opinion, the development of the field of toxicogenomics will provide powerful and relatively inexpensive tools to identify biomarkers and to relate exposure and biological events during disease progression. JF - Annals of the New York Academy of Sciences AU - Olden, Kenneth AD - Cell Adhesion and Metastasis Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, olden@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 703 EP - 706 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 IS - 1 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Genetics Abstracts KW - Metabolites KW - proteomics KW - Xenobiotics KW - genomics KW - Drugs KW - biomarkers KW - metabolomics KW - X 24300:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Toxicogenomics-A+New+Systems+Toxicology+Approach+to+Understanding+of+Gene-Environment+Interactions&rft.au=Olden%2C+Kenneth&rft.aulast=Olden&rft.aufirst=Kenneth&rft.date=2006-09-01&rft.volume=1076&rft.issue=1&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1371.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - References, 8. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metabolites; genomics; Xenobiotics; proteomics; biomarkers; Drugs; metabolomics DO - http://dx.doi.org/10.1196/annals.1371.026 ER - TY - JOUR T1 - Effect of Fluoridated Public Water Supplies on Dental Caries Prevalence AN - 20493202; 7791463 AB - As early as 1942, it had been adequately demonstrated that the use of fluoride-bearing drinking waters produces a marked reduction in the incidence of dental caries. It was also known by that time that this beneficial effect occurs in populations using water supplies containing fluoride from natural sources in concentrations below the level established as the threshold for mottled enamel or endemic fluorosis. JF - Bulletin of The World Health Organization AU - Arnold, FA Jr AU - Dean, H T AU - Jay, P AU - Knutson, J W AD - National Institute of Dental Research, National Institutes of Health, Public Health Service Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 761 VL - 84 IS - 9 SN - 0042-9686, 0042-9686 KW - Aqualine Abstracts KW - Drinking Water KW - Water Supply KW - Public Waters KW - Fluorides KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20493202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+The+World+Health+Organization&rft.atitle=Effect+of+Fluoridated+Public+Water+Supplies+on+Dental+Caries+Prevalence&rft.au=Arnold%2C+FA+Jr%3BDean%2C+H+T%3BJay%2C+P%3BKnutson%2C+J+W&rft.aulast=Arnold&rft.aufirst=FA&rft.date=2006-09-01&rft.volume=84&rft.issue=9&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+The+World+Health+Organization&rft.issn=00429686&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drinking Water; Water Supply; Public Waters; Fluorides ER - TY - JOUR T1 - Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering AN - 20295516; 7536776 AB - The feasibility of size exclusion chromotography (SEC)-multiangle laser-light scattering as a technique to investigate aggregation and degradation of glycosylated and nonglycosylated proteins, and antibodies under various conditions such as addition of detergent, changes in pH, and variation of protein concentration and heat stress temperature was examined. Separation of proteins and their aggregates was performed using SEC-high-performance liquid chromatography. Detection of analytes was carried out with on-line UV, refractive index, and multiangle laser light-scattering detectors. Quantification and molecular weight determination were performed using commercial software. Aggregation and degradation were examined under various conditions and quantitative results are presented for bovine serum albumin, choriogonadotropin, glyceraldehyde-3-phosphate dehydrogenase, Herceptin, and ReoPro. This method can simultaneously determine both the quantities and the molecular weights of macromolecules from a single injection. The determination of molecular weight is absolute which avoids misleading results caused by molecular shape or interactions with the column matrix. This technique is valuable not only for assessing the extent of aggregation but also for effectively monitoring molecule degradation as evidenced by molecular weight reduction and change in monomer amount. JF - Analytical Biochemistry AU - Ye, Hongping AD - Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA, yeh@cder.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 76 EP - 85 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 356 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - SEC-MALLS KW - Protein aggregation KW - Absolute molecular weight KW - Protein degradation KW - Pharmaceutical proteins KW - Glycoproteins KW - Temperature effects KW - Macromolecules KW - Detergents KW - Light scattering KW - Stress KW - Monomers KW - Computer programs KW - Glyceraldehyde-3-phosphate dehydrogenase KW - software KW - Antibodies KW - Bovine serum albumin KW - Liquid chromatography KW - Heat KW - Molecular weight KW - Lasers KW - pH effects KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20295516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Simultaneous+determination+of+protein+aggregation%2C+degradation%2C+and+absolute+molecular+weight+by+size+exclusion+chromatography-multiangle+laser+light+scattering&rft.au=Ye%2C+Hongping&rft.aulast=Ye&rft.aufirst=Hongping&rft.date=2006-09-01&rft.volume=356&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2006.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Macromolecules; Detergents; Light scattering; Stress; Monomers; Computer programs; Antibodies; software; Glyceraldehyde-3-phosphate dehydrogenase; Bovine serum albumin; Heat; Liquid chromatography; Molecular weight; Lasers; pH effects; Protein interaction DO - http://dx.doi.org/10.1016/j.ab.2006.05.025 ER - TY - JOUR T1 - Hazardous Anticancer Drugs in Health Care: Environmental Exposure Assessment AN - 20161852; 7191057 AB - Exposure of healthcare workers to anticancer drugs became problematic in the 1970s. Shortly thereafter, studies began documenting exposure of healthcare workers to these drugs. Investigations employing biological markers, such as urine mutagenicity, chromosomal aberrations, sister chromatid exchanges, and micronuclei, demonstrated associations between occupational exposures and elevated marker levels. Other analytical methods emerged to monitor workplaces where drugs were handled. These contemporary studies uncovered widespread contamination of drugs on work surfaces, trace amounts in air samples, and their presence in the urine of workers. Vials containing these drugs are often contaminated with the drug when they are shipped. Most workplace surfaces are contaminated with the drugs being prepared and used in that area. Other anticancer/hazardous drugs would most likely be used in these areas. The interior surfaces of biological safety cabinets and isolators, floors, countertops, carts, storage bins, waste containers, treatment areas, tabletops, chairs, linen, and other items are all potential sources of exposure to anticancer drugs. Patient body fluids contain the drugs and/or metabolites, often more biologically active than the parent compounds. An exposure assessment of areas where anticancer/hazardous drugs are handled must consider every potential source and route of exposure. Data from surface contamination and inhalation studies suggest that dermal exposure is the primary route of exposure. Assessment of exposure is the first step in providing a safe work environment for these workers. However, because of the many drugs to which they are exposed, any assessment can only be an estimation of the overall exposure. JF - Annals of the New York Academy of Sciences AU - Connor, Thomas H AD - NIOSH MS C-23, Cincinnati, Ohio 45226, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 615 EP - 623 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Containers KW - Contamination KW - Micronuclei KW - Metabolites KW - Medical personnel KW - Workers KW - Air sampling KW - Chromosome aberrations KW - Drugs KW - Body fluids KW - Occupational exposure KW - Mutagenicity KW - Data processing KW - Skin KW - Wastes KW - sister chromatids KW - biomarkers KW - Antitumor agents KW - Storage KW - Health care KW - Urine KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20161852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Hazardous+Anticancer+Drugs+in+Health+Care%3A+Environmental+Exposure+Assessment&rft.au=Connor%2C+Thomas+H&rft.aulast=Connor&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Mutagenicity; Skin; Data processing; Contamination; Micronuclei; Wastes; sister chromatids; Metabolites; Antitumor agents; biomarkers; Medical personnel; Workers; Urine; Drugs; Chromosome aberrations; Occupational exposure; Body fluids; Storage; Containers; Health care; Air sampling ER - TY - JOUR T1 - Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats AN - 19856498; 6969111 AB - Aristolochic acid (AA) is present in at least 65 different kinds of plants, many of which are used as herbal folk remedies. AA is considered one of the most potent plant carcinogens in humans and animals. It has been associated with the development of urothelial cancers in humans, and kidney and forestomach tumors in rats. In the present study, we used the Big Blue transgenic rat model to evaluate the mutagenicity of AA in kidney of rats and to define the mechanism of action for the tumor induction by AA. Groups of six male Big Blue transgenic rats were gavaged with 0, 0.1, 1.0 and 10.0 mg AA/kg body weight 5 times a week for 12 weeks, a treatment protocol that resulted in tumors in kidneys and other tissues. The animals were sacrificed 1 day after the final treatment and the kidneys were isolated for assays to determine the mutant frequencies (MFs) and types of mutations induced by AA in the transgenic cII gene. AA treatment resulted in a strong linear relationship between MF inductions and treatment dose (R super(2) = 0.998). The cII MFs were 29 +/- 6 x 10 super(-6), 78 +/- 21 x 10 super(-6), 242 +/- 104 x 10 super(-6) and 1319 +/- 360 x 10 super(-6) in the control, low, medium and high dose treatment groups, respectively (p - 0.001 for all pair wise comparisons among the four treatment groups). These MFs correlated strongly with tumor incidences induced by the different doses of AA (Mengs et al., 1982). Sequence analysis of the cII mutants revealed that there was a statistically significant difference between the mutational spectra in the AA- treated and control rats (p - 0.05). A:T --> T:A transversion was the predominant type of mutation in the AA-treated rats whereas G:C --> A:T transition was the main type of mutations in the control rats. These results suggest that AA induces kidney tumors in rats though a mutagenic mechanism of action. JF - Toxicology Letters AU - Chen, Ling AU - Mei, Nan AU - Yao, Lei AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA, tchen@nctr.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 250 EP - 256 PB - Elsevier Science Ireland Ltd., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 165 IS - 3 SN - 0378-4274, 0378-4274 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Aristolochic acid KW - Mutagenicity KW - Kidney KW - Herb KW - Mutational spectrum KW - Carcinogenesis KW - Statistical analysis KW - Animal models KW - Mutant frequency KW - Tumors KW - Carcinogens KW - urothelial cancer KW - Transversion KW - Transgenic animals KW - Body weight KW - Herbal medicines KW - Mutation KW - W 30950:Waste Treatment & Pollution Clean-up KW - G 07800:Plants and Algae KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Science+and+Biotechnology&rft.atitle=Occurrence+of+Vibrio+parahaemolyticus+in+Fishery+Products+from+the+Southwestern+Coast+of+Korea&rft.au=Yoon%2C+CY%3BKang%2C+K+J&rft.aulast=Yoon&rft.aufirst=CY&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Food+Science+and+Biotechnology&rft.issn=12267708&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Animal models; Statistical analysis; Mutant frequency; Carcinogens; Tumors; urothelial cancer; Transversion; Transgenic animals; Body weight; Aristolochic acid; Kidney; Herbal medicines; Mutation DO - http://dx.doi.org/10.1016/j.toxlet.2006.04.008 ER - TY - JOUR T1 - TRANSFUSION COMPLICATIONS: Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety AN - 19847086; 7103131 AB - BACKGROUND:Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS:A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS:Vaccinia viremia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viremia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION:The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low. JF - Transfusion AU - Srinivasan, Kumar AU - Akolkar, Pradip N AU - Taffs, Rolf E AU - Hewlett, Indira K AD - Kumar Srinivasan, PhD, HFM-315, FDA, CBER, DETTD, 1401 Rockville Pike, Rockville MD 20852-1448, kumar.srinivasan@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1589 EP - 1592 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 46 IS - 9 SN - 0041-1132, 0041-1132 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Blood donors KW - vaccines KW - Vero cells KW - bioterrorism KW - Disasters KW - Cell culture KW - clinical trials KW - Vaccination KW - Clinical trials KW - Smallpox KW - Peripheral blood mononuclear cells KW - Vaccinia virus KW - Blood transfusion KW - Viremia KW - Vaccines KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=TRANSFUSION+COMPLICATIONS%3A+Absence+of+detectable+viremia+in+plasma+and+peripheral+blood+mononuclear+cells+from+smallpox+vaccinees%3A+implications+for+blood+safety&rft.au=Srinivasan%2C+Kumar%3BAkolkar%2C+Pradip+N%3BTaffs%2C+Rolf+E%3BHewlett%2C+Indira+K&rft.aulast=Srinivasan&rft.aufirst=Kumar&rft.date=2006-09-01&rft.volume=46&rft.issue=9&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2006.04.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Tables, 2; references, 8. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smallpox; Blood donors; Peripheral blood mononuclear cells; Blood transfusion; Vero cells; bioterrorism; Cell culture; Vaccines; Viremia; Clinical trials; Vaccination; vaccines; Disasters; clinical trials; Vaccinia virus DO - http://dx.doi.org/10.1111/j.1537-2995.2006.00936.x ER - TY - JOUR T1 - Inactivation of Clostridium botulinum nonproteolytic type B spores by high pressure processing at moderate to elevated high temperatures AN - 19844254; 6989855 AB - The effect of high pressure and high temperature treatments at various process times on the inactivation of spores of Clostridium botulinum nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B, suspended in phosphate buffer (0.067 M, pH 7.0) and a crabmeat blend was investigated. Spores of KAP8-B were less resistant to high pressure treatment than the spores of 2-B, 17-B, and KAP9-B in both phosphate buffer and crabmeat blend. No survivors of initial counts (> 4.3 log units) of KAP8-B spores were detected in these menstura after processing at 827 MPa and 60 degree C for 10 min. The amount of inactivation of spores of 2-B, 17-B, and KAP9-B in phosphate buffer or crabmeat blend increased with the increase in processing time from 10 to 30 min at 827 MPa and 75 degree C. Similar inactivation patterns were observed for these spores in both phosphate buffer and crabmeat blend. A reduction of > 6-log units of 2-B, 17-B, and KAP9-B spores in phosphate buffer and crabmeat blend was observed at 827 MPa and 75 degree C for a processing time of between 20 and 30 min. Crabmeat blend as a suspension menstrum provided no protection against inactivation of spores of 2-B, 17-B, and KAP9-B by high pressure processing. High temperature (> 95 degree C) and lower pressure (620 MPa) treatments for up to 10 min were also found to inactivate 17-B spores in phosphate buffer. Spores of nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B in phosphate buffer and crabmeat blend can be inactivated by a combination of high pressure and temperature treatments. Industrial relevance Spores of nonproteolytic type B strains of Clostridium botulinum are of primary concern because they have been involved in the foodborne botulism outbreaks associated with marine products. Foodborne botulism results from consumption of these foods in which C. botulinum has grown and produced neurotoxin. Recently, high pressure processing (HPP) received a great deal of interest because of its ability to destroy vegetative pathogens, viruses, and certain bacterial spores and results in a product with natural sensory, quality, and nutritional attributes. Currently, HPP is being evaluated at the National Center for Food Safety and Technology as an alternative to other traditional thermal processes for its ability to inactivate C. botulinum spores. In this study, the effects of high pressure in conjunction with moderate to elevated high temperatures on inactivation of C. botulinum nonproteolytic type B spores were investigated. Based on limited number of strains tested, HPP showed a potential of destroying spores of nonproteolytic type B strains of C. botulinum when process temperature is above 75 degree C. JF - Innovative Food Science and Emerging Technologies AU - Reddy, N R AU - Tetzloff, R C AU - Solomon, H M AU - Larkin, J W AD - National Center for Food Safety and Technology, Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA, rukma.reddy@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 169 EP - 175 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 7 IS - 3 SN - 1466-8564, 1466-8564 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - High pressure processing KW - Inactivation KW - Clostridium botulinum KW - Spores KW - inactivation KW - buffers KW - Food KW - Viruses KW - Nutrition KW - Food consumption KW - Pressure KW - pH effects KW - pH KW - Temperature effects KW - Botulism KW - Temperature KW - outbreaks KW - Pathogens KW - Food contamination KW - Sensory properties KW - Phosphates KW - Phosphate KW - innovations KW - Neurotoxins KW - high temperature KW - Technology KW - V 22490:Miscellaneous KW - X 24370:Natural Toxins KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Innovative+Food+Science+and+Emerging+Technologies&rft.atitle=Inactivation+of+Clostridium+botulinum+nonproteolytic+type+B+spores+by+high+pressure+processing+at+moderate+to+elevated+high+temperatures&rft.au=Reddy%2C+N+R%3BTetzloff%2C+R+C%3BSolomon%2C+H+M%3BLarkin%2C+J+W&rft.aulast=Reddy&rft.aufirst=N&rft.date=2006-09-01&rft.volume=7&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Innovative+Food+Science+and+Emerging+Technologies&rft.issn=14668564&rft_id=info:doi/10.1016%2Fj.ifset.2006.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sensory properties; Temperature effects; Food consumption; Phosphate; Botulism; Food; Pathogens; Neurotoxins; Pressure; Spores; pH effects; inactivation; buffers; Viruses; Temperature; outbreaks; Food contamination; Nutrition; Phosphates; innovations; pH; high temperature; Technology; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.ifset.2006.03.002 ER - TY - RPRT T1 - Ergonomics and Mining: Charting a Path to a Safer Workplace AN - 19638144; 7371898 AB - Ergonomics processes described in the literature have been associated mostly with manufacturing, financial, electronics, and office settings where working conditions tend to be rather constant and repetitive. The information presented in this document demonstrates, however, that an ergonomics process can also be implemented in a setting such as mining where working conditions frequently change and workers are periodically exposed to extreme weather conditions. This document describes how Bridger Coal Company implemented an ergonomics process at its Jim Bridger Mine from 2001 through 2004. The process developed by the Ergonomics Committee, the promotion of the process to management and employees, and the impacts of the process on working conditions at the mine are reviewed. Barriers overcome and lessons learned are also described. Quotes from Bridger Coal Company employees are included in the document to add a personal perspective. Other industries with working conditions similar to mining, such as construction and agriculture, may find this information useful. JF - Ergonomics and mining: charting a path to a safer workplace. [np]. Sep 2006. AU - Torma-Krajewski, J AU - Steiner, L AU - Lewis, P AU - Gust, P AU - Johnson, K Y1 - 2006/09// PY - 2006 DA - Sep 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - NIOSH 2006-104 KW - Weather KW - Reviews KW - agriculture KW - committees KW - Coal KW - Mines KW - Ergonomics KW - working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19638144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Torma-Krajewski%2C+J%3BSteiner%2C+L%3BLewis%2C+P%3BGust%2C+P%3BJohnson%2C+K&rft.aulast=Torma-Krajewski&rft.aufirst=J&rft.date=2006-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.title=Ergonomics+and+Mining%3A+Charting+a+Path+to+a+Safer+Workplace&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 ER - TY - JOUR T1 - Impact of microarray data quality on genomic data submissions to the FDA AN - 19613933; 7333120 AB - How can microarray data best be exploited and integrated into the regulatory decision-making process? JF - Nature Biotechnology AU - Frueh, F W AD - US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluationand Research, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA, felix.frueh@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1105 EP - 1107 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Decision making KW - Data processing KW - genomics KW - DNA microarrays KW - W 30900:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Impact+of+microarray+data+quality+on+genomic+data+submissions+to+the+FDA&rft.au=Frueh%2C+F+W&rft.aulast=Frueh&rft.aufirst=F&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0906-1105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Decision making; Data processing; genomics; DNA microarrays DO - http://dx.doi.org/10.1038/nbt0906-1105 ER - TY - JOUR T1 - Apoptosis and Bax Expression are Increased by Coal Dust in the Polycyclic Aromatic Hydrocarbon-Exposed Lung AN - 19546992; 7263161 AB - BACKGROUND: Miners inhaling respirable coal dust (CD) frequently develop coal workers' pneumoconiosis, a dust-associated pneumoconiosis characterized by lung inflammation and variable fibrosis. Many coal miners are also exposed to polycyclic aromatic hydrocarbon (PAH) components of diesel engine exhaust and cigarette smoke, which may contribute to lung disease in these workers. Recently, apoptosis was reported to play a critical role in the development of another pneumoconiosis of miners, silicosis. In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs. METHODS: We investigated the hypothesis that apoptosis plays a critical role in lung injury and down-regulation of CYP1A1 induction in mixed exposures to CD and PAHs. We exposed rats intratracheally to 0.0, 2.5, 10.0, 20.0, or 40.0 mg/rat CD and, 11 days later, to intraperitoneal beta -naphthoflavone (BNF), a PAH. In another group of rats exposed to CD and BNF, caspase activity was inhibited by injection of the pan-caspase inhibitor Q-VD-OPH [quinoline-Val-Asp (OMe)-CH sub(2)-OPH]. RESULTS: In rats exposed to BNF, CD exposure increased alveolar expression of the proapoptotic mediator Bax but decreased CYP1A1 induction relative to BNF exposure alone. Pan-caspase inhibition decreased CD-associated Bax expression and apoptosis but did not restore CYP1A1 activity. Further, CD-induced lung inflammation and alveolar epithelial cell hypertrophy and hyperplasia were not suppressed by caspase inhibition. CONCLUSIONS: Combined BNF and CD exposure increased Bax expression and apoptosis in the lung, but Bax and apoptosis were not the major determinants of early lung injury in this model. JF - Environmental Health Perspectives AU - Ghanem, M M AU - Battelli, LA AU - Mercer, R R AU - Scabilloni, J F AU - Kashon, M L AU - Ma, JYC AU - Nath, J AU - Hubbs, A F AD - Pathology and Physiology Research Branch, Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505 USA, Ahubbs@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1367 EP - 1373 VL - 114 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Inhalation KW - Epithelial cells KW - Apoptosis KW - Injuries KW - Fibrosis KW - Pneumoconiosis KW - Animal models KW - Cigarette smoke KW - Coal KW - Dust KW - Silicosis KW - Occupational exposure KW - Polycyclic aromatic hydrocarbons KW - Lung diseases KW - Alveoli KW - Inflammation KW - Exhausts KW - Smoke KW - Hyperplasia KW - Hypertrophy KW - Cytochrome KW - beta -Naphthoflavone KW - Lung KW - Bax protein KW - Diesel KW - Caspase KW - Coal dust KW - Mining KW - Cytochrome P450 KW - Diesel engines KW - Aromatics KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19546992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Apoptosis+and+Bax+Expression+are+Increased+by+Coal+Dust+in+the+Polycyclic+Aromatic+Hydrocarbon-Exposed+Lung&rft.au=Ghanem%2C+M+M%3BBattelli%2C+LA%3BMercer%2C+R+R%3BScabilloni%2C+J+F%3BKashon%2C+M+L%3BMa%2C+JYC%3BNath%2C+J%3BHubbs%2C+A+F&rft.aulast=Ghanem&rft.aufirst=M&rft.date=2006-09-01&rft.volume=114&rft.issue=9&rft.spage=1367&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8906 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Polycyclic aromatic hydrocarbons; Apoptosis; Fibrosis; Lung diseases; Animal models; Pneumoconiosis; Cigarette smoke; Coal; Alveoli; Exhausts; Inflammation; Hypertrophy; Hyperplasia; beta -Naphthoflavone; Silicosis; Bax protein; Coal dust; Caspase; Diesel; Cytochrome P450; Aromatics; Occupational exposure; Inhalation; Injuries; Dust; Smoke; Cytochrome; Lung; Mining; Diesel engines DO - http://dx.doi.org/10.1289/ehp.8906 ER - TY - JOUR T1 - Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids AN - 19545383; 7259769 AB - We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report that DHP-derived DNA adducts are formed in the liver of female F344 rats, gavaged with three dietary supplements (comfrey root extract, comfrey compound oil, and coltsfoot root extract), or an extract of a Chinese herbal plant, flos farfara (Kuan Tong Hua). JF - Toxicology and Industrial Health AU - Chou, M W AU - Fu, P P AD - Division of Biochemical Toxicology, HFT-140, National Center for Toxicological Research, Jefferson, AR 72079, USA, mchou@nctr.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 321 EP - 327 VL - 22 IS - 8 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - pyrrolizidine alkaloids KW - Oil KW - DNA adducts KW - Dietary supplements KW - Herbal medicines KW - Liver KW - Tumorigenicity KW - Plant extracts KW - biomarkers KW - Metabolism KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19545383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Formation+of+DHP-derived+DNA+adducts+in+vivo+from+dietary+supplements+and+Chinese+herbal+plant+extracts+containing+carcinogenic+pyrrolizidine+alkaloids&rft.au=Chou%2C+M+W%3BFu%2C+P+P&rft.aulast=Chou&rft.aufirst=M&rft.date=2006-09-01&rft.volume=22&rft.issue=8&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233706071765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oil; pyrrolizidine alkaloids; DNA adducts; Dietary supplements; Liver; Herbal medicines; Tumorigenicity; Plant extracts; biomarkers; Metabolism DO - http://dx.doi.org/10.1177/0748233706071765 ER - TY - JOUR T1 - Potential Health Effects of Occupational Chlorinated Solvent Exposure AN - 19507027; 7191021 AB - Based on toxicology, metabolism, animal studies, and human studies, occupational exposure to chlorinated aliphatic solvents (methanes, ethanes, and ethenes) has been associated with numerous adverse health effects, including central nervous system, reproductive, liver, and kidney toxicity, and carcinogenicity. However, many of these solvents remain in active, large-volume use. This article reviews the recent occupational epidemiology literature on the most widely used solvents, methylene chloride, chloroform, trichloroethylene, and tetrachloroethylene, and discusses other chlorinated aliphatics. The impact of studies to date has been lessened because of small study size, inability to control for confounding factors, particularly smoking and mixed occupational exposures, and the lack of evidence for a solid pathway from occupational exposure to biological evidence of exposure, to precursors of health effects, and to health effects. International differences in exposure limits may provide a "natural experiment" in the coming years if countries that have lowered exposure limits subsequently experience decreased adverse health effects among exposed workers. Such decreases could provide some evidence that higher levels of adverse health effects were associated with higher levels of solvent exposure. The definitive studies, which should be prospective biomarker studies incorporating body burden of solvents as well as markers of effect, remain to be done. JF - Annals of the New York Academy of Sciences AU - Ruder, Avima M AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 207 EP - 227 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - ethene KW - Chlorides KW - Chloroform KW - Smoking KW - Carcinogenicity KW - Trichloroethylene KW - Occupational exposure KW - Bioindicators KW - Methane KW - Solvents KW - Toxicity KW - biomarkers KW - Epidemiology KW - Reviews KW - Kidney KW - Liver KW - Tetrachloroethylene KW - Metabolism KW - Methylene chloride KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19507027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Potential+Health+Effects+of+Occupational+Chlorinated+Solvent+Exposure&rft.au=Ruder%2C+Avima+M&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Methane; ethene; Solvents; Toxicity; biomarkers; Smoking; Chloroform; Epidemiology; Carcinogenicity; Reviews; Liver; Kidney; Trichloroethylene; Tetrachloroethylene; Methylene chloride; Metabolism; Occupational exposure; Bioindicators; Chlorides ER - TY - JOUR T1 - Comparison of Performance of Three Different Types of Respiratory Protection Devices AN - 19392263; 7152827 AB - Respiratory protection is offered to American workers in a variety of ways to guard against potential inhalation hazards. Two of the most common ways are elastomeric N95 respirators and N95 filtering-facepiece respirators. Some in the health care industry feel that surgical masks provide an acceptable level of protection in certain situations against particular hazards. This study compared the performance of these types of respiratory protection during a simulated workplace test that measured both filter penetration and face-seal leakage. A panel of 25 test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020, and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. The results of these tests produced a simulated workplace protection factor (SWPF). The geometric mean (GM) and the 5th percentile values of the SWPFs were computed by category of respiratory protection using the six overall SWPF values. The level of protection provided by each of the three respiratory protection types was compared. The GM and 5th percentile SWPF values without fit testing were used for the comparison, as surgical masks were not intended to be fit tested. The GM values were 36 for elastomeric N95 respirators, 21 for N95 filtering-facepiece respirators, and 3 for surgical masks. An analysis of variance demonstrated a statistically significant difference between all three. Elastomeric N95 respirators had the highest 5th percentile SWPF of 7. N95 filtering-facepiece respirators and surgical masks had 5th percentile SWPFs of 3 and 1, respectively. A Fisher Exact Test revealed that the 5th percentile SWPFs for all three types of respiratory protection were statistically different. In addition, both qualitative (Bitrex and saccharin) and quantitative (N95-Companion)fit testing were performed on the N95 filtering- and elastomeric-facepiece respirators. It was found that passing a fit test generally improves the protection afforded the wearer. Passing the Bitrex fit test resulted in 5th percentile SWPFs of 11.1 and 7.9 for elastomeric and filtering-facepiece respirators, respectively. After passing the saccharin tests, the elastomeric respirators provided a 5th percentile of 11.7, and the filtering-facepiece respirators provided a 5th percentile of 11.0. The 5th percentiles after passing the N95-Companion were 13.0 for the elastomeric respirators and 20.5 for the filtering-facepiece respirators. The data supports fit testing as an essential element of a complete respiratory protection program. JF - Journal of Occupational and Environmental Hygiene AU - Lawrence, R B AU - Duling, M G AU - Calvert, CA AU - Coffey, C C AD - NIOSH, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, rbl2@cdc.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 465 EP - 474 VL - 3 IS - 9 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Filters KW - Leakage KW - Performance KW - Respirators KW - Hygiene KW - Protective equipment KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+Cashew+Nut+DNA+in+Spiked+Baked+Goods+Using+a+Real-Time+Polymerase+Chain+Reaction+Method&rft.au=Brzezinski%2C+J+L&rft.aulast=Brzezinski&rft.aufirst=J&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Filters; Inhalation; Leakage; Performance; Hygiene; Respirators; Protective equipment; Occupational exposure DO - http://dx.doi.org/10.1080/15459620600829211 ER - TY - JOUR T1 - Mycobacterium tuberculosis Delta RD1 Delta panCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis AN - 19338132; 7079555 AB - The global epidemic of tuberculosis (TB), fueled by the growing HIV pandemic, warrants the development of a safe and effective vaccine against TB. We report the construction and characterization of an unlinked double deletion mutant of Mycobacterium tuberculosis H37Rv that deletes both the primary attenuating mutation of BCG ( Delta RD1) and two genes required for the synthesis of pantothenate ( Delta panCD). The M. tuberculosis Delta RD1 Delta panCD (mc super(2)6030) mutant undergoes limited replication in mice, and yet is both significantly safer than BCG in immunocompromised mice and also safe in guinea pigs. Additionally, the mc super(2)6030 strain does not reactivate in a mouse chemo- immunosuppression model. Importantly, long-lived protective immune responses following immunization with the mc super(2)6030 strain prolong the survival of wild type mice, and CD4-deficient mice against an aerosol challenge with virulent M. tuberculosis. Given its overall safety and effectiveness, the mc super(2)6030 live attenuated strain should be considered as a human vaccine candidate for protecting both healthy and HIV-infected individuals against TB. JF - Vaccine AU - Sambandamurthy, Vasan K AU - Derrick, Steven C AU - Hsu, Tsungda AU - Chen, Bing AU - Larsen, Michelle H AU - Jalapathy, Kripa V AU - Chen, Mei AU - Kim, John AU - Porcelli, Steven A AU - Chan, John AU - Morris, Sheldon L AU - Jacobs, William R AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States, jacobsw@hhmi.org Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 6309 EP - 6320 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 24 IS - 37-39 SN - 0264-410X, 0264-410X KW - HIV KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Tuberculosis KW - Mycobacterial vaccines KW - BCG KW - Attenuated strains KW - Aerosols KW - Deletion mutant KW - Epidemics KW - Replication KW - Animal models KW - Survival KW - Immunization KW - pandemics KW - CD4 antigen KW - Human immunodeficiency virus KW - Vaccines KW - Mutation KW - Mycobacterium tuberculosis KW - Immunosuppression KW - J 02310:Genetics & Taxonomy KW - F 06905:Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Mycobacterium+tuberculosis+Delta+RD1+Delta+panCD%3A+A+safe+and+limited+replicating+mutant+strain+that+protects+immunocompetent+and+immunocompromised+mice+against+experimental+tuberculosis&rft.au=Sambandamurthy%2C+Vasan+K%3BDerrick%2C+Steven+C%3BHsu%2C+Tsungda%3BChen%2C+Bing%3BLarsen%2C+Michelle+H%3BJalapathy%2C+Kripa+V%3BChen%2C+Mei%3BKim%2C+John%3BPorcelli%2C+Steven+A%3BChan%2C+John%3BMorris%2C+Sheldon+L%3BJacobs%2C+William+R&rft.aulast=Sambandamurthy&rft.aufirst=Vasan&rft.date=2006-09-01&rft.volume=24&rft.issue=37-39&rft.spage=6309&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Aerosols; Epidemics; Deletion mutant; Replication; Animal models; Survival; Immunization; CD4 antigen; pandemics; BCG; Tuberculosis; Vaccines; Mutation; Immunosuppression; Human immunodeficiency virus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2006.05.097 ER - TY - JOUR T1 - Maternal infection and white matter toxicity AN - 19326631; 7074634 AB - Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology. JF - Neurotoxicology AU - Harry, GJean AU - Lawler, Cindy AU - Brunssen, Susan H AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA, harry@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 658 EP - 670 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Microglia KW - White matter damage KW - Inflammation KW - Oligodendrocyte KW - Immune status KW - Neurological diseases KW - Oligodendrocytes KW - Risk factors KW - Disseminated infection KW - Substantia alba KW - Progeny KW - Toxicity KW - Pregnancy KW - Infants KW - N3 11028:Neuropharmacology & toxicology KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19326631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Maternal+infection+and+white+matter+toxicity&rft.au=Harry%2C+GJean%3BLawler%2C+Cindy%3BBrunssen%2C+Susan+H&rft.aulast=Harry&rft.aufirst=GJean&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2006.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immune status; Neurological diseases; Oligodendrocytes; Risk factors; Disseminated infection; Substantia alba; Progeny; Toxicity; Infants; Inflammation; Pregnancy DO - http://dx.doi.org/10.1016/j.neuro.2006.05.004 ER - TY - JOUR T1 - Separate Pathways for O Acetylation of Polymeric and Monomeric Sialic Acids and Identification of Sialyl O-Acetyl Esterase in Escherichia coli K1 AN - 19325474; 7061479 AB - O acetylation at carbon positions 7 or 9 of the sialic acid residues in the polysialic acid capsule of Escherichia coli K1 is catalyzed by a phase-variable contingency locus, neuO, carried by the K1-specific prophage, CUS-3. Here we describe a novel method for analyzing polymeric sialic acid O acetylation that involves the release of surface sialic acids by endo-N-acetylneuraminidase digestion, followed by fluorescent labeling and detection of quinoxalinone derivatives by chromatography. The results indicated that NeuO is responsible for the majority of capsule modification that takes place in vivo. However, a minor neuO-independent O acetylation pathway was detected that is dependent on the bifunctional polypeptide encoded by neuD. This pathway involves O acetylation of monomeric sialic acid and is regulated by another bifunctional enzyme, NeuA, which includes N-terminal synthetase and C-terminal sialyl O-esterase domains. A homologue of the NeuA C-terminal domain (Pm1710) in Pasteurella multocida was also shown to be an esterase, suggesting that it functions in the catabolism of acetylated environmental sialic acids. Our combined results indicate a previously unexpected complexity in the synthesis and catabolism of microbial sialic and polysialic acids. These findings are key to understanding the biological functions of modified sialic acids in E. coli K1 and other species and may provide new targets for drug or vaccine development. JF - Journal of Bacteriology AU - Steenbergen, Susan M AU - Lee, Young-Choon AU - Vann, Willie F AU - Vionnet, Justine AU - Wright, Lori F AU - Vimr, Eric R AD - Laboratory of Sialobiology and Comparative Metabolomics, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois. Department of Biotechnology, Dong-A University, Busan, South Korea. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland. Department of Microbiology and Immunology, University of Rochester, Rochester, New York Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 6195 EP - 6206 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 17 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Chromatography KW - esterase KW - Bifunctional enzymes KW - Pasteurella multocida KW - Drug development KW - Prophages KW - Digestion KW - Acetylation KW - Carbon KW - Escherichia coli KW - polysialic acid KW - Vaccines KW - Sialic acids KW - Contingency KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19325474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Separate+Pathways+for+O+Acetylation+of+Polymeric+and+Monomeric+Sialic+Acids+and+Identification+of+Sialyl+O-Acetyl+Esterase+in+Escherichia+coli+K1&rft.au=Steenbergen%2C+Susan+M%3BLee%2C+Young-Choon%3BVann%2C+Willie+F%3BVionnet%2C+Justine%3BWright%2C+Lori+F%3BVimr%2C+Eric+R&rft.aulast=Steenbergen&rft.aufirst=Susan&rft.date=2006-09-01&rft.volume=188&rft.issue=17&rft.spage=6195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Digestion; Acetylation; Carbon; Chromatography; esterase; Bifunctional enzymes; Drug development; Vaccines; polysialic acid; Prophages; Contingency; Sialic acids; Escherichia coli; Pasteurella multocida ER - TY - JOUR T1 - Quinupristin-Dalfopristin Resistance in Enterococcus faecium Isolates from Humans, Farm Animals, and Grocery Store Meat in the United States AN - 19324597; 7062396 AB - Three hundred sixty-one quinupristin-dalfopristin (Q-D)-resistant Enterococcus faecium (QDREF) isolates were isolated from humans, turkeys, chickens, swine, dairy and beef cattle from farms, chicken carcasses, and ground pork from grocery stores in the United States from 1995 to 2003. These isolates were evaluated by pulsed-field gel electrophoresis (PFGE) to determine possible commonality between QDREF isolates from human and animal sources. PCR was performed to detect the streptogramin resistance genes vatD, vatE, and vgbA and the macrolide resistance gene ermB to determine the genetic mechanism of resistance in these isolates. QDREF from humans did not have PFGE patterns similar to those from animal sources. vatE was found in 35%, 26%, and 2% of QDREF isolates from turkeys, chickens, and humans, respectively, and was not found in QDREF isolates from other sources. ermB was commonly found in QDREF isolates from all sources. Known streptogramin resistance genes were absent in the majority of isolates, suggesting the presence of other, as-yet-undetermined, mechanisms of Q-D resistance. JF - Journal of Clinical Microbiology AU - Donabedian, S M AU - Perri, M B AU - Vager, D AU - Hershberger, E AU - Malani, P AU - Simjee, S AU - Chow, J AU - Vergis, EN AU - Muder, R R AU - Gay, K AU - Angulo, F J AU - Bartlett, P AU - Zervos, MJ AD - Henry Ford Hospital, Detroit, Michigan. University of Michigan Medical Center, Ann Arbor, Michigan. Food and Drug Administration, Centers for Veterinary Medicine, Rockville, Maryland. Wayne State University, Detroit, Michigan. Veterans Affairs Medical Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Centers for Disease Control and Prevention, Emerging Infections Program, Atlanta, Georgia. Michigan State University College of Veterinary Medicine, Lansing, Michigan Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3361 EP - 3365 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Farms KW - Streptogramins KW - quinupristin-dalfopristin KW - Pork KW - Enterococcus faecium KW - Meat KW - USA KW - Dairies KW - Carcasses KW - Beef KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19324597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Quinupristin-Dalfopristin+Resistance+in+Enterococcus+faecium+Isolates+from+Humans%2C+Farm+Animals%2C+and+Grocery+Store+Meat+in+the+United+States&rft.au=Donabedian%2C+S+M%3BPerri%2C+M+B%3BVager%2C+D%3BHershberger%2C+E%3BMalani%2C+P%3BSimjee%2C+S%3BChow%2C+J%3BVergis%2C+EN%3BMuder%2C+R+R%3BGay%2C+K%3BAngulo%2C+F+J%3BBartlett%2C+P%3BZervos%2C+MJ&rft.aulast=Donabedian&rft.aufirst=S&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=3361&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Meat; Dairies; Carcasses; Farms; Beef; Streptogramins; quinupristin-dalfopristin; Pork; Pulsed-field gel electrophoresis; Polymerase chain reaction; Enterococcus faecium; USA ER - TY - JOUR T1 - Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209) AN - 19322736; 7062798 AB - Our recent studies have shown that the dendritic cell-specific ICAM nonintegrin CD209 (DC-SIGN) specifically binds to the core LPS of Escherichia coli K12 (E. coli), promoting bacterial adherence and phagocytosis. In this current study, we attempted to map the sites within the core LPS that are directly involved in LPS-DC-SIGN interaction. We took advantage of four sets of well-defined core LPS mutants, which are derived from E. coli, Salmonella enterica serovar Typhimurium, Neisseria gonorrhoeae, and Haemophilus ducreyi and determined interaction of each of these four sets with DC-SIGN. Our results demonstrated that N-acetylglucosamine (GlcNAc) sugar residues within the core LPS in these bacteria play an essential role in targeting the DC-SIGN receptor. Our results also imply that DC-SIGN is an innate immune receptor and the interaction of bacterial core LPS and DC-SIGN may represent a primeval interaction between Gram-negative bacteria and host phagocytic cells. JF - Journal of Immunology AU - Zhang, Pei AU - Snyder, Scott AU - Feng, Peter AU - Azadi, Parastoo AU - Zhang, Shusheng AU - Bulgheresi, Silvia AU - Sanderson, Kenneth E AU - He, Johnny AU - Klena, John AU - Chen, Tie AD - Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Rockford, IL 61107. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602. Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, MD 20740. Faculty of Life Sciences, Department of Marine Biology, University of Vienna, Vienna, Austria. Salmonella Genetic Stock Centre, Department of Biological Sciences, Alberta, Canada. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202. School of Biological Sciences, University of Canterbury, Christchurch, New Zealand Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 4002 EP - 4011 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Sugar KW - N-Acetylglucosamine KW - Neisseria gonorrhoeae KW - Cores KW - DC-SIGN protein KW - Phagocytes KW - Salmonella enterica KW - Gram-negative bacteria KW - Escherichia coli KW - Lipopolysaccharides KW - Phagocytosis KW - Haemophilus ducreyi KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19322736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Role+of+N-Acetylglucosamine+within+Core+Lipopolysaccharide+of+Several+Species+of+Gram-Negative+Bacteria+in+Targeting+the+DC-SIGN+%28CD209%29&rft.au=Zhang%2C+Pei%3BSnyder%2C+Scott%3BFeng%2C+Peter%3BAzadi%2C+Parastoo%3BZhang%2C+Shusheng%3BBulgheresi%2C+Silvia%3BSanderson%2C+Kenneth+E%3BHe%2C+Johnny%3BKlena%2C+John%3BChen%2C+Tie&rft.aulast=Zhang&rft.aufirst=Pei&rft.date=2006-09-01&rft.volume=177&rft.issue=6&rft.spage=4002&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sugar; Cores; Phagocytes; DC-SIGN protein; Gram-negative bacteria; Lipopolysaccharides; N-Acetylglucosamine; Phagocytosis; Salmonella enterica; Escherichia coli; Neisseria gonorrhoeae; Haemophilus ducreyi ER - TY - JOUR T1 - The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements AN - 19319430; 7046484 AB - Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings. JF - Nature Biotechnology AU - Reid, Laura H AU - Jones, Wendell D AU - Shippy, Richard AU - Warrington, Janet A AU - Baker, Shawn C AU - Collins, Patrick J AU - De Longueville, Francoise AU - Kawasaki, Ernest S AU - Lee, Kathleen Y AU - Luo, Yuling AU - Sun, Yongming Andrew AU - Willey, James C AU - Setterquist, Robert A AU - Fischer, Gavin M AU - Tong, Weida AU - Dragan, Yvonne P AU - Dix, David J AU - Frueh, Felix W AU - Goodsaid, Federico M AU - Herman, Damir AU - Jensen, Roderick V AU - Johnson, Charles D AU - Lobenhofer, Edward K AU - Puri, Raj K AU - Scherf, Uwe AU - Thierry-Mieg, Jean AU - Wang, Charles AU - Wilson, Mike AU - Wolber, Paul K AU - Zhang, Lu AU - Amur, Shashi AU - Bao, Wenjun AU - Barbacioru, Catalin C AU - Lucas, Anne Bergstrom AU - Bertholet, Vincent AU - Boysen, Cecilie AU - Bromley, Bud AU - Brown, Donna AU - Brunner, Alan AU - Canales, Roger AU - Cao, Xiaoxi Megan AU - Cebula, Thomas A AU - Chen, James J AU - Cheng, Jing AU - Chu, Tzu-Ming AU - Chudin, Eugene AU - Corson, John AU - Corton, J Christopher AU - Croner, Lisa J AU - Davies, Christopher AU - Davison, Timothy S AU - Delenstarr, Glenda AU - Deng, Xutao AU - Dorris, David AU - Eklund, Aron C AU - Fan, Xiao-Hui AU - Fang, Hong AU - Fulmer-Smentek, Stephanie AU - Fuscoe, James C AU - Gallagher, Kathryn AU - Ge, Weigong AU - Guo, Lei AU - Guo, Xu AU - Hager, Janet AU - Haje, Paul K AU - Han, Jing AU - Han, Tao AU - Harbottle, Heather C AU - Harris, Stephen C AU - Hatchwell, Eli AU - Hauser, Craig A AU - Hester, Susan AU - Hong, Huixiao AU - Hurban, Patrick AU - Jackson, Scott A AU - Ji, Hanlee AU - Knight, Charles R AU - Kuo, Winston P AU - LeClerc, J Eugene AU - Levy, Shawn AU - Li, Quan-Zhen AU - Liu, Chunmei AU - Liu, Ying AU - Lombardi, Michael J AU - Ma, Yunqing AU - Magnuson, Scott R AU - Maqsodi, Botoul AU - McDaniel, Tim AU - Mei, Nan AU - Myklebost, Ola AU - Ning, Baitang AU - Novoradovskaya, Natalia AU - Orr, Michael S AU - Osborn, Terry W AU - Papallo, Adam AU - Patterson, Tucker A AU - Perkins, Roger G AU - Peters, Elizabeth H AU - Peterson, Ron AU - Philips, Kenneth L AU - Pine, P Scott AU - Pusztai, Lajos AU - Qian, Feng AU - Ren, Hongzu AU - Rosen, Mitch AU - Rosenzweig, Barry A AU - Samaha, Raymond R AU - Schena, Mark AU - Schroth, Gary P AU - Shchegrova, Svetlana AU - Smith, Dave D AU - Staedtler, Frank AU - Su, Zhenqiang AU - Sun, Hongmei AU - Szallasi, Zoltan AU - Tezak, Zivana AU - Thierry-Mieg, Danielle AU - Thompson, Karol L AU - Tikhonova, Irina AU - Turpaz, Yaron AU - Vallanat, Beena AU - Van, Christophe AU - Walker, Stephen J AU - Wang, Sue Jane AU - Wang, Yonghong AU - Wolfinger, Russ AU - Wong, Alex AU - Wu, Jie AU - Xiao, Chunlin AU - Xie, Qian AU - Xu, Jun AU - Yang, Wen AU - Zhang, Liang AU - Zhong, Sheng AU - Zong, Yaping AU - Slikker, William AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA., leming.shi@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1151 EP - 1161 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Quality control KW - DNA probes KW - Titration KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19319430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=The+MicroArray+Quality+Control+%28MAQC%29+project+shows+inter-+and+intraplatform+reproducibility+of+gene+expression+measurements&rft.au=Reid%2C+Laura+H%3BJones%2C+Wendell+D%3BShippy%2C+Richard%3BWarrington%2C+Janet+A%3BBaker%2C+Shawn+C%3BCollins%2C+Patrick+J%3BDe+Longueville%2C+Francoise%3BKawasaki%2C+Ernest+S%3BLee%2C+Kathleen+Y%3BLuo%2C+Yuling%3BSun%2C+Yongming+Andrew%3BWilley%2C+James+C%3BSetterquist%2C+Robert+A%3BFischer%2C+Gavin+M%3BTong%2C+Weida%3BDragan%2C+Yvonne+P%3BDix%2C+David+J%3BFrueh%2C+Felix+W%3BGoodsaid%2C+Federico+M%3BHerman%2C+Damir%3BJensen%2C+Roderick+V%3BJohnson%2C+Charles+D%3BLobenhofer%2C+Edward+K%3BPuri%2C+Raj+K%3BScherf%2C+Uwe%3BThierry-Mieg%2C+Jean%3BWang%2C+Charles%3BWilson%2C+Mike%3BWolber%2C+Paul+K%3BZhang%2C+Lu%3BAmur%2C+Shashi%3BBao%2C+Wenjun%3BBarbacioru%2C+Catalin+C%3BLucas%2C+Anne+Bergstrom%3BBertholet%2C+Vincent%3BBoysen%2C+Cecilie%3BBromley%2C+Bud%3BBrown%2C+Donna%3BBrunner%2C+Alan%3BCanales%2C+Roger%3BCao%2C+Xiaoxi+Megan%3BCebula%2C+Thomas+A%3BChen%2C+James+J%3BCheng%2C+Jing%3BChu%2C+Tzu-Ming%3BChudin%2C+Eugene%3BCorson%2C+John%3BCorton%2C+J+Christopher%3BCroner%2C+Lisa+J%3BDavies%2C+Christopher%3BDavison%2C+Timothy+S%3BDelenstarr%2C+Glenda%3BDeng%2C+Xutao%3BDorris%2C+David%3BEklund%2C+Aron+C%3BFan%2C+Xiao-Hui%3BFang%2C+Hong%3BFulmer-Smentek%2C+Stephanie%3BFuscoe%2C+James+C%3BGallagher%2C+Kathryn%3BGe%2C+Weigong%3BGuo%2C+Lei%3BGuo%2C+Xu%3BHager%2C+Janet%3BHaje%2C+Paul+K%3BHan%2C+Jing%3BHan%2C+Tao%3BHarbottle%2C+Heather+C%3BHarris%2C+Stephen+C%3BHatchwell%2C+Eli%3BHauser%2C+Craig+A%3BHester%2C+Susan%3BHong%2C+Huixiao%3BHurban%2C+Patrick%3BJackson%2C+Scott+A%3BJi%2C+Hanlee%3BKnight%2C+Charles+R%3BKuo%2C+Winston+P%3BLeClerc%2C+J+Eugene%3BLevy%2C+Shawn%3BLi%2C+Quan-Zhen%3BLiu%2C+Chunmei%3BLiu%2C+Ying%3BLombardi%2C+Michael+J%3BMa%2C+Yunqing%3BMagnuson%2C+Scott+R%3BMaqsodi%2C+Botoul%3BMcDaniel%2C+Tim%3BMei%2C+Nan%3BMyklebost%2C+Ola%3BNing%2C+Baitang%3BNovoradovskaya%2C+Natalia%3BOrr%2C+Michael+S%3BOsborn%2C+Terry+W%3BPapallo%2C+Adam%3BPatterson%2C+Tucker+A%3BPerkins%2C+Roger+G%3BPeters%2C+Elizabeth+H%3BPeterson%2C+Ron%3BPhilips%2C+Kenneth+L%3BPine%2C+P+Scott%3BPusztai%2C+Lajos%3BQian%2C+Feng%3BRen%2C+Hongzu%3BRosen%2C+Mitch%3BRosenzweig%2C+Barry+A%3BSamaha%2C+Raymond+R%3BSchena%2C+Mark%3BSchroth%2C+Gary+P%3BShchegrova%2C+Svetlana%3BSmith%2C+Dave+D%3BStaedtler%2C+Frank%3BSu%2C+Zhenqiang%3BSun%2C+Hongmei%3BSzallasi%2C+Zoltan%3BTezak%2C+Zivana%3BThierry-Mieg%2C+Danielle%3BThompson%2C+Karol+L%3BTikhonova%2C+Irina%3BTurpaz%2C+Yaron%3BVallanat%2C+Beena%3BVan%2C+Christophe%3BWalker%2C+Stephen+J%3BWang%2C+Sue+Jane%3BWang%2C+Yonghong%3BWolfinger%2C+Russ%3BWong%2C+Alex%3BWu%2C+Jie%3BXiao%2C+Chunlin%3BXie%2C+Qian%3BXu%2C+Jun%3BYang%2C+Wen%3BZhang%2C+Liang%3BZhong%2C+Sheng%3BZong%2C+Yaping%3BSlikker%2C+William&rft.aulast=Reid&rft.aufirst=Laura&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; RNA; DNA probes; Quality control; Titration; DNA microarrays DO - http://dx.doi.org/10.1038/nbt1239 ER - TY - JOUR T1 - Evaluation of external RNA controls for the assessment of microarray performance AN - 19317343; 7046482 AB - External RNA controls (ERCs), although important for microarray assay performance assessment, have yet to be fully implemented in the research community. As part of the MicroArray Quality Control (MAQC) study, two types of ERCs were implemented and evaluated; one was added to the total RNA in the samples before amplification and labeling; the other was added to the copyRNAs (cRNAs) before hybridization. ERC concentration-response curves were used across multiple commercial microarray platforms to identify problematic assays and potential sources of variation in the analytical process. In addition, the behavior of different ERC types was investigated, resulting in several important observations, such as the sample-dependent attributes of performance and the potential of using these control RNAs in a combinatorial fashion. This multiplatform investigation of the behavior and utility of ERCs provides a basis for articulating specific recommendations for their future use in evaluating assay performance across multiple platforms. JF - Nature Biotechnology AU - Tong, Weida AU - Lucas, Anne Bergstrom AU - Shippy, Richard AU - Fan, Xiaohui AU - Fang, Hong AU - Hong, Huixiao AU - Orr, Michael S AU - Chu, Tzu-Ming AU - Guo, Xu AU - Collins, Patrick J AU - Sun, Yongming Andrew AU - Wang, Sue-Jane AU - Bao, Wenjun AU - Wolfinger, Russell D AU - Shchegrova, Svetlana AU - Guo, Lei AU - Warrington, Janet A AU - Shi, Leming AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA., weida.tong@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1132 EP - 1139 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - RNA KW - Quality control KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19317343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Evaluation+of+external+RNA+controls+for+the+assessment+of+microarray+performance&rft.au=Tong%2C+Weida%3BLucas%2C+Anne+Bergstrom%3BShippy%2C+Richard%3BFan%2C+Xiaohui%3BFang%2C+Hong%3BHong%2C+Huixiao%3BOrr%2C+Michael+S%3BChu%2C+Tzu-Ming%3BGuo%2C+Xu%3BCollins%2C+Patrick+J%3BSun%2C+Yongming+Andrew%3BWang%2C+Sue-Jane%3BBao%2C+Wenjun%3BWolfinger%2C+Russell+D%3BShchegrova%2C+Svetlana%3BGuo%2C+Lei%3BWarrington%2C+Janet+A%3BShi%2C+Leming&rft.aulast=Tong&rft.aufirst=Weida&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1132&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA microarrays; RNA; Quality control DO - http://dx.doi.org/10.1038/nbt1237 ER - TY - JOUR T1 - Rat toxicogenomic study reveals analytical consistency across microarray platforms AN - 19316101; 7046483 AB - To validate and extend the findings of the MicroArray Quality Control (MAQC) project, a biologically relevant toxicogenomics data set was generated using 36 RNA samples from rats treated with three chemicals (aristolochic acid, riddelliine and comfrey) and each sample was hybridized to four microarray platforms. The MAQC project assessed concordance in intersite and cross-platform comparisons and the impact of gene selection methods on the reproducibility of profiling data in terms of differentially expressed genes using distinct reference RNA samples. The real-world toxicogenomic data set reported here showed high concordance in intersite and cross-platform comparisons. Further, gene lists generated by fold-change ranking were more reproducible than those obtained by t-test P value or Significance Analysis of Microarrays. Finally, gene lists generated by fold-change ranking with a nonstringent P- value cutoff showed increased consistency in Gene Ontology terms and pathways, and hence the biological impact of chemical exposure could be reliably deduced from all platforms analyzed. JF - Nature Biotechnology AU - Guo, Lei AU - Lobenhofer, Edward K AU - Wang, Charles AU - Shippy, Richard AU - Harris, Stephen C AU - Zhang, Lu AU - Mei, Nan AU - Chen, Tao AU - Herman, Damir AU - Goodsaid, Federico M AU - Hurban, Patrick AU - Phillips, Kenneth L AU - Xu, Jun AU - Deng, Xutao AU - Sun, Yongming Andrew AU - Tong, Weida AU - Dragan, Yvonne P AU - Shi, Leming AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA., lei.guo@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1162 EP - 1169 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - rats KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Toxicology Abstracts KW - RNA KW - Quality control KW - Aristolochic acid KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19316101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Rat+toxicogenomic+study+reveals+analytical+consistency+across+microarray+platforms&rft.au=Guo%2C+Lei%3BLobenhofer%2C+Edward+K%3BWang%2C+Charles%3BShippy%2C+Richard%3BHarris%2C+Stephen+C%3BZhang%2C+Lu%3BMei%2C+Nan%3BChen%2C+Tao%3BHerman%2C+Damir%3BGoodsaid%2C+Federico+M%3BHurban%2C+Patrick%3BPhillips%2C+Kenneth+L%3BXu%2C+Jun%3BDeng%2C+Xutao%3BSun%2C+Yongming+Andrew%3BTong%2C+Weida%3BDragan%2C+Yvonne+P%3BShi%2C+Leming&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1238 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - RNA; Quality control; Aristolochic acid DO - http://dx.doi.org/10.1038/nbt1238 ER - TY - JOUR T1 - Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project AN - 19315497; 7046486 AB - Microarray-based expression profiling experiments typically use either a one-color or a two-color design to measure mRNA abundance. The validity of each approach has been amply demonstrated. Here we provide a simultaneous comparison of results from one- and two-color labeling designs, using two independent RNA samples from the Microarray Quality Control (MAQC) project, tested on each of three different microarray platforms. The data were evaluated in terms of reproducibility, specificity, sensitivity and accuracy to determine if the two approaches provide comparable results. For each of the three microarray platforms tested, the results show good agreement with high correlation coefficients and high concordance of differentially expressed gene lists within each platform. Cumulatively, these comparisons indicate that data quality is essentially equivalent between the one- and two-color approaches and strongly suggest that this variable need not be a primary factor in decisions regarding experimental microarray design. JF - Nature Biotechnology AU - Patterson, Tucker A AU - Lobenhofer, Edward K AU - Fulmer-Smentek, Stephanie B AU - Collins, Patrick J AU - Chu, Tzu-Ming AU - Bao, Wenjun AU - Fang, Hong AU - Kawasaki, Ernest S AU - Hager, Janet AU - Tikhonova, Irina R AU - Walker, Stephen J AU - Zhang, Liang AU - Hurban, Patrick AU - De Longueville, Francoise AU - Fuscoe, James C AU - Tong, Weida AU - Shi, Leming AU - Wolfinger, Russell D AD - National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA., tucker.patterson@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1140 EP - 1150 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Abundance KW - DNA microarrays KW - Color KW - mRNA KW - Quality control KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19315497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Performance+comparison+of+one-color+and+two-color+platforms+within+the+Microarray+Quality+Control+%28MAQC%29+project&rft.au=Patterson%2C+Tucker+A%3BLobenhofer%2C+Edward+K%3BFulmer-Smentek%2C+Stephanie+B%3BCollins%2C+Patrick+J%3BChu%2C+Tzu-Ming%3BBao%2C+Wenjun%3BFang%2C+Hong%3BKawasaki%2C+Ernest+S%3BHager%2C+Janet%3BTikhonova%2C+Irina+R%3BWalker%2C+Stephen+J%3BZhang%2C+Liang%3BHurban%2C+Patrick%3BDe+Longueville%2C+Francoise%3BFuscoe%2C+James+C%3BTong%2C+Weida%3BShi%2C+Leming%3BWolfinger%2C+Russell+D&rft.aulast=Patterson&rft.aufirst=Tucker&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1140&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1242 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Quality control; DNA microarrays; Abundance; mRNA; Color DO - http://dx.doi.org/10.1038/nbt1242 ER - TY - JOUR T1 - Serum Brain-Derived Neurotrophic Factor Concentrations in Lean and Overweight Children and Adolescents AN - 19315369; 7062272 AB - CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. Design/Setting/Patients: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean plus or minus SD, 39.8 plus or minus 24.8 vs. 47.0 plus or minus 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function. JF - Journal of Clinical Endocrinology and Metabolism AU - El-Gharbawy, Areeg H AU - Adler-Wailes, Diane C AU - Mirch, Margaret C AU - Theim, Kelly R AU - Ranzenhofer, Lisa AU - Tanofsky-Kraff, Marian AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1103 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3548 EP - 3552 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 91 IS - 9 SN - 0021-972X, 0021-972X KW - Physical Education Index; CSA Neurosciences Abstracts KW - Measurement KW - Age KW - Animal subjects KW - Body mass KW - Body weight KW - Weight KW - Regression analysis KW - Races KW - Sex KW - Brain-derived neurotrophic factor KW - Obesity KW - Enzyme-linked immunosorbent assay KW - Adolescence KW - Multiple regression analysis KW - Patients KW - Children KW - TrkB receptors KW - Energy balance KW - Analysis KW - haploinsufficiency KW - Platelets KW - Adipose tissue KW - Body fat KW - Body mass index KW - Mutation KW - N3 11009:Neuroendocrinology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19315369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Serum+Brain-Derived+Neurotrophic+Factor+Concentrations+in+Lean+and+Overweight+Children+and+Adolescents&rft.au=El-Gharbawy%2C+Areeg+H%3BAdler-Wailes%2C+Diane+C%3BMirch%2C+Margaret+C%3BTheim%2C+Kelly+R%3BRanzenhofer%2C+Lisa%3BTanofsky-Kraff%2C+Marian%3BYanovski%2C+Jack+A&rft.aulast=El-Gharbawy&rft.aufirst=Areeg&rft.date=2006-09-01&rft.volume=91&rft.issue=9&rft.spage=3548&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Age; Weight; Body mass; Animal subjects; Analysis; Adolescence; Patients; Children; Sex; Brain-derived neurotrophic factor; Enzyme-linked immunosorbent assay; Multiple regression analysis; TrkB receptors; Body weight; Energy balance; haploinsufficiency; Regression analysis; Platelets; Body fat; Adipose tissue; Body mass index; Mutation; Races ER - TY - JOUR T1 - Evaluation of DNA microarray results with quantitative gene expression platforms AN - 19312602; 7046481 AB - We have evaluated the performance characteristics of three quantitative gene expression technologies and correlated their expression measurements to those of five commercial microarray platforms, based on the MicroArray Quality Control (MAQC) data set. The limit of detection, assay range, precision, accuracy and fold-change correlations were assessed for 997 TaqMan Gene Expression Assays, 205 Standardized RT (Sta)RT-PCR assays and 244 QuantiGene assays. TaqMan is a registered trademark of Roche Molecular Systems, Inc. We observed high correlation between quantitative gene expression values and microarray platform results and found few discordant measurements among all platforms. The main cause of variability was differences in probe sequence and thus target location. A second source of variability was the limited and variable sensitivity of the different microarray platforms for detecting weakly expressed genes, which affected interplatform and intersite reproducibility of differentially expressed genes. From this analysis, we conclude that the MAQC microarray data set has been validated by alternative quantitative gene expression platforms thus supporting the use of microarray platforms for the quantitative characterization of gene expression. JF - Nature Biotechnology AU - Canales, Roger D AU - Luo, Yuling AU - Willey, James C AU - Austermiller, Bradley AU - Barbacioru, Catalin C AU - Boysen, Cecilie AU - Hunkapiller, Kathryn AU - Jensen, Roderick V AU - Knight, Charles R AU - Lee, Kathleen Y AU - Ma, Yunqing AU - Maqsodi, Botoul AU - Papallo, Adam AU - Peters, Elizabeth Herness AU - Poulter, Karen AU - Ruppel, Patricia L AU - Samaha, Raymond R AU - Shi, Leming AU - Yang, Wen AU - Zhang, Lu AU - Goodsaid, Federico M AD - Applied Biosystems, 850 Lincoln Centre Dr., Foster City, California 94404, USA., Federico.Goodsaid@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1115 EP - 1122 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 9 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Gene expression KW - Data processing KW - DNA probes KW - Quality control KW - Probes KW - DNA microarrays KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - N 14010:Physical & Computer Methods & Assays KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19312602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Evaluation+of+DNA+microarray+results+with+quantitative+gene+expression+platforms&rft.au=Canales%2C+Roger+D%3BLuo%2C+Yuling%3BWilley%2C+James+C%3BAustermiller%2C+Bradley%3BBarbacioru%2C+Catalin+C%3BBoysen%2C+Cecilie%3BHunkapiller%2C+Kathryn%3BJensen%2C+Roderick+V%3BKnight%2C+Charles+R%3BLee%2C+Kathleen+Y%3BMa%2C+Yunqing%3BMaqsodi%2C+Botoul%3BPapallo%2C+Adam%3BPeters%2C+Elizabeth+Herness%3BPoulter%2C+Karen%3BRuppel%2C+Patricia+L%3BSamaha%2C+Raymond+R%3BShi%2C+Leming%3BYang%2C+Wen%3BZhang%2C+Lu%3BGoodsaid%2C+Federico+M&rft.aulast=Canales&rft.aufirst=Roger&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=1115&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Quality control; DNA probes; Probes; DNA microarrays DO - http://dx.doi.org/10.1038/nbt1236 ER - TY - JOUR T1 - Heterogeneity of vat(E)-carrying plasmids in Enterococcus faecium recovered from human and animal sources AN - 19296343; 7045450 AB - In this study, quinupristin/dalfopristin (Q/D)-resistant Enterococcus faecium isolates (33 from poultry farms and 1 from a human outpatient) with Q/D minimal inhibitory concentrations ranging from 4 mu g/mL to 32 mu g/mL were analysed. Polymerase chain reaction detected the presence of vat(E) in all isolates. Using pulsed-field gel electrophoresis (PFGE), 14 distinct PFGE patterns were identified. The human E. faecium isolate was distinguishable from the 33 farm isolates by PFGE. Southern hybridisation localised the vat(E) gene to an 11 kb plasmid and resulted in five plasmid hybridisation types. The vat(E)-carrying plasmid from the human isolate showed a nearly identical hybridisation pattern to a plasmid from a farm isolate. This study showed that the vat(E) gene, conferring resistance to Q/D, was carried on different plasmids in a heterogeneous group of E. faecium, some of which may be acquired by E. faecium capable of infecting humans. JF - International Journal of Antimicrobial Agents AU - Simjee, Shabbir AU - Zhang, Yifan AU - McDermott, Patrick F AU - Donabedian, Susan M AU - Zervos, Marcus J AU - Meng, Jianghong AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD, USA, jmeng@umd.edu Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 200 EP - 205 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 28 IS - 3 SN - 0924-8579, 0924-8579 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - E. faecium KW - Plasmids KW - Streptogramin resistance KW - Virginiamycin KW - Dalfopristin KW - Poultry KW - Farms KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - quinupristin KW - Enterococcus faecium KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19296343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Bovine+kidney+tissue%2Fbiological+fluid+correlation+for+penicillin.&rft.au=Chiesa%2C+O+A%3BVon+Bredow%2C+J%3BSmith%2C+M%3BHeller%2C+D%3BCondon%2C+R%3BThomas%2C+M+H&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-08-01&rft.volume=29&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=01407783&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Poultry; Dalfopristin; Farms; Pulsed-field gel electrophoresis; Polymerase chain reaction; quinupristin; Plasmids; Antimicrobial agents; Enterococcus faecium DO - http://dx.doi.org/10.1016/j.ijantimicag.2006.04.004 ER - TY - JOUR T1 - Toxic cyanobacteria in the lakes located in Riga (the capital of Latvia) and its surroundings: present state of knowledge AN - 19292257; 7354439 AB - The intensity and toxicity of cyanobacterial blooms in lakes located near Riga (the capital of Latvia) were investigated between 1998 and 2004. These lakes are shallow eutrophic water bodies with a high surface to depth ratio and are widely used for recreational and fishing activities. Intense cyanobacterial blooms were associated with calm weather, high water temperatures (>20 degree C), and low oxygen saturation in surface (40-70%) and bottom (1-30%) waters. The maximum biomass of harmful cyanobacteria occurred during August-September. Cyanobacterial blooms were dominated by Anabaena spp., Aphanizomenon flos-aquae and Microcystis spp. A significant decrease of the Shannon-Wiener species diversity index was observed during bloom periods. Hepatotoxins (microcystins) were detected in 50% of the surveyed lakes. High-performance liquid chromatography analysis of algal biomass indicated the presence of microcystins MC-LR, MC-YR, MC-RR and MC-LA. The most abundant was MC-LR, contributing on average 43% of the total microcystins. Microcystin concentrations showed a significant interannual variation. The highest concentration of microcystins was observed in Lake Lielais Baltezers. JF - African Journal of Marine Science AU - Balode, M AU - Purina, I AU - Strake, S AU - Purvina, S AU - Pfeifere, M AU - Barda, I AU - Povidisa, K Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 225 EP - 230 VL - 28 IS - 2 SN - 1814-232X, 1814-232X KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Ecology Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - High-performance liquid chromatography KW - Aphanizomenon flos-aquae KW - Algal blooms KW - Eutrophic waters KW - Microcystins KW - Eutrophic environments KW - marine sciences KW - Phytoplankton KW - Anabaena KW - Freshwater KW - Freshwater fish KW - Public health KW - Microcystis KW - Fishing KW - Lakes KW - eutrophic water KW - Latvia KW - Algae KW - Weather KW - Biological poisons KW - microcystins KW - Toxicity KW - Water temperature KW - Biomass KW - Oxygen KW - Cyanobacteria KW - Recreation KW - Liquid chromatography KW - Recreation areas KW - Species diversity KW - fishing KW - Cyanophyta KW - water temperature KW - X 24370:Natural Toxins KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09183:Physics and chemistry KW - K 03450:Ecology KW - Q1 08481:Productivity KW - Q5 08524:Public health, medicines, dangerous organisms KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19292257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=African+Journal+of+Marine+Science&rft.atitle=Toxic+cyanobacteria+in+the+lakes+located+in+Riga+%28the+capital+of+Latvia%29+and+its+surroundings%3A+present+state+of+knowledge&rft.au=Balode%2C+M%3BPurina%2C+I%3BStrake%2C+S%3BPurvina%2C+S%3BPfeifere%2C+M%3BBarda%2C+I%3BPovidisa%2C+K&rft.aulast=Balode&rft.aufirst=M&rft.date=2006-09-01&rft.volume=28&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=African+Journal+of+Marine+Science&rft.issn=1814232X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Algal blooms; Lakes; Recreation; Eutrophic waters; Biological poisons; Phytoplankton; Freshwater fish; Public health; High-performance liquid chromatography; Oxygen; Fishing; Weather; Eutrophic environments; Microcystins; Species diversity; Water temperature; Toxicity; Biomass; Algae; marine sciences; microcystins; Recreation areas; Liquid chromatography; eutrophic water; fishing; water temperature; Microcystis; Aphanizomenon flos-aquae; Cyanobacteria; Anabaena; Cyanophyta; Latvia; Freshwater ER - TY - JOUR T1 - Inhibition of mammalian target of rapamycin modulates expression of adhesion molecules in endothelial cells AN - 17241892; 6969110 AB - Neointimal hyperplasia often follows angioplasty-induced arterial injury or stenting and results in restenosis. Previous reports have suggested that arterial injury activates complement which amplifies inflammatory responses that may initiate and sustain neointimal hyperplasia. The effects of rapamycin on complement-induced expression of intracellular adhesion molecules (ICAMs) were examined in porcine arterial endothelial cell (PAEC) line that was transformed with large T antigen. Porcine complement was activated by treating sera with zymosan (PO ZYM) to generate C5b-9. C5b-9 binds to PAEC in a concentration- and time-dependent manner. PO ZYM-induced expression of ICAMs was maximally induced by 18 h. Rapamycin reduced the expression of vascular cell adhesion molecule (VCAM) and P-selectin in a concentration-dependent manner. Adhesion of monocytes was reduced by rapamycin and the inhibition was prevented by antibodies to vascular cell adhesion molecule, P-selectin and endothelial-leukocyte adhesion molecule (ELAM). In summary, inhibition of the mammalian target of rapamycin down regulates complement-induced ICAMs expression which may modulate inflammatory responses that follow stent implant-induced restenosis during percutanous coronary interventions. JF - Toxicology Letters AU - Wood, Steven C AU - Bushar, Grace AU - Tesfamariam, Belay AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, CDRH, FDA, Building 64, Rm 3026, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA, steven.wood@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 242 EP - 249 PB - Elsevier Science Ireland Ltd., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 165 IS - 3 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Rapamycin KW - Cell adhesion molecules KW - Endothelial cells KW - mTOR signaling KW - Complement KW - restenosis KW - P-selectin KW - Inflammation KW - Hyperplasia KW - Antibodies KW - Monocytes KW - TOR protein KW - Vascular system KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17241892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Inhibition+of+mammalian+target+of+rapamycin+modulates+expression+of+adhesion+molecules+in+endothelial+cells&rft.au=Wood%2C+Steven+C%3BBushar%2C+Grace%3BTesfamariam%2C+Belay&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Antibodies; Hyperplasia; Complement; restenosis; P-selectin; Monocytes; TOR protein; Rapamycin; Cell adhesion molecules; Vascular system; Inflammation DO - http://dx.doi.org/10.1016/j.toxlet.2006.04.009 ER - TY - JOUR T1 - Effects of zearalenone on in utero development in rats AN - 17238341; 6968598 AB - Zearalenone (ZE), an estrogenic mycotoxin produced by Fusarium graminearum or F. roseum, is one of the most common contaminants of cereal grains world-wide. The objective of this study was to determine the effects of ZE on in utero development of rats. Pregnant female Charles River Sprague-Dawley rats were gavaged once daily with ZE (in corn oil) at doses of 0, 1, 2, 4, or 8 mg/kg body weight on gestation days (GD) 6-19. All females survived to cesarean section on GD 20. At cesarean section, reproductive and developmental parameters were measured and blood was taken for hormone analysis. Dose-related decreases were seen in maternal feed consumption and body weight gain in all treated groups. Delayed fetal development was linked to maternal toxicity. Fetal body weight was significantly decreased in both sexes in all treated groups. ZE retarded skeletal ossification at 4 and 8 mg/kg. Fetal anogenital index (anogenital distance normalized for body weight) was increased in all treated groups, indicating an androgenic effect of ZE during fetal development. Fetal viability was significantly decreased at 8 mg/kg; significant decreases were observed in number of viable fetuses, and number of litters totally resorbed. At 4 and 8 mg/kg, maternal liver-body weight ratios were significantly increased and organ-brain weight ratios for weights of liver, heart, spleen, kidneys, and ovaries were significantly decreased. Gonadotropins (LH, FSH, and prolactin) and sex steroids (progesterone and estradiol) were analyzed from the blood serum obtained at cesarean section. LH in the 0, 1, 2, and 4 mg/kg groups showed minimal variation, and slightly increased at 8 mg/kg. FSH was decreased in the 1, 2, and 4 mg/kg groups, but the level at 8 mg/kg was slightly higher than the control level. Prolactin level was not affected at 1 mg/kg, slightly increased at 2 and 4 mg/kg, and significantly increased at 8 mg/kg. Progesterone was decreased at 2, 4, and 8 mg/kg and the decreases were significant at 2 and 4 mg/kg. Estradiol level was not affected at 1 mg/kg, but dose-related decreases were observed at 2, 4, and 8 mg/kg. Only the 8 mg/kg level of estradiol was significantly decreased. In summary, ZE was maternally toxic and fetotoxic but not teratogenic. The increased anogenital distance observed in male and female fetuses was considered a hormonal change rather than a teratologic response. The increased anogenital distance indicated an androgenic effect. Based on the dose- related maternal and fetal toxicity in all treated groups, the NOEL for reproductive and teratogenic effects was less than 1 mg/kg. JF - Food and Chemical Toxicology AU - Collins, Thomas FX AU - Sprando, Robert L AU - Black, Thomas N AU - Olejnik, Nicholas AU - Eppley, Robert M AU - Alam, Hamida Z AU - Rorie, James AU - Ruggles, Dennis I AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA, tcollins@cfsan.fda.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1455 EP - 1465 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 9 SN - 0278-6915, 0278-6915 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Zearalenone KW - Estrogenic mycotoxin KW - Developmental toxicity KW - Rat KW - Follicle-stimulating hormone KW - Progesterone KW - Anogenital KW - Development KW - Hormones KW - Oil KW - Cereals KW - Body weight KW - Gestation KW - Sex KW - Rivers KW - Heart KW - Litter KW - Gonadotropins KW - Spleen KW - Toxicity KW - Steroid hormones KW - Fusarium graminearum KW - Fetuses KW - Estradiol KW - Pregnancy KW - Prolactin KW - Blood KW - Mycotoxins KW - Ossification KW - Liver KW - Kidney KW - Grain KW - Cesarean section KW - Teratogenicity KW - Ovaries KW - Body weight gain KW - Contaminants KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03410:Animal Diseases KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17238341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+zearalenone+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BAlam%2C+Hamida+Z%3BRorie%2C+James%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Zearalenone; Follicle-stimulating hormone; Progesterone; Anogenital; Development; Hormones; Oil; Body weight; Cereals; Gestation; Sex; Heart; Rivers; Litter; Gonadotropins; Spleen; Steroid hormones; Toxicity; Estradiol; Fetuses; Pregnancy; Prolactin; Blood; Mycotoxins; Ossification; Grain; Kidney; Liver; Cesarean section; Teratogenicity; Ovaries; Contaminants; Body weight gain; Fusarium graminearum DO - http://dx.doi.org/10.1016/j.fct.2006.04.015 ER - TY - JOUR T1 - Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma AN - 1709177478; 15622683 AB - In this study, we hypothesized that the altered insulin and glucose levels in male pancreatic cancer patients reported in a recent JAMA article would result in an altered lipid profile in the blood of pancreatic cancer patients when compared to controls (Stolzenberg-Solomon et al., 2005). Proton nuclear magnetic resonance (NMR) spectra of human lipophilic plasma extracts were used in order to build partial least squares discriminant function (PLS-DF) models that classified samples as belonging to the pancreatic control group or to the pancreatic cancer group. The sensitivity, specificity, and overall accuracy of the PLS-DF models based on 4 bins were 96%, 88%, and 92%, respectively. The sensitivity, specificity, and overall accuracy of the PLS-DF models based on 5 bins were 98%, 94%, and 96%, respectively. The sensitivity, specificity and overall accuracy of both the 4-bin and 5-bin PLS-DF models dropped only 1-2% during leave-25%-out cross-validation testing. Mass spectrometric profiling of phospholipids in plasma found three phosphatidylinositols that were significantly lower in pancreatic cancer patients than in healthy controls. The cancer models are based upon changes in lipid profiles that may provide a more sensitive and accurate diagnosis of pancreatic cancer than current methods that are based upon a single biomarker. JF - Metabolomics AU - Beger, Richard D AU - Schnackenberg, Laura K AU - Holland, Ricky D AU - Li, Donghui AU - Dragan, Yvonne AD - Division of Systems Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, 72079-9502, USA, Richard.Beger@fda.hhs.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 125 EP - 134 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 2 IS - 3 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Protons KW - phosphatidylinositol KW - Lipids KW - Glucose KW - Pancreatic cancer KW - biomarkers KW - Insulin KW - Lipophilic KW - Models KW - Blood KW - N.M.R. KW - metabolomics KW - Phospholipids KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709177478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabonomic+models+of+human+pancreatic+cancer+using+1D+proton+NMR+spectra+of+lipids+in+plasma&rft.au=Beger%2C+Richard+D%3BSchnackenberg%2C+Laura+K%3BHolland%2C+Ricky+D%3BLi%2C+Donghui%3BDragan%2C+Yvonne&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2006-09-01&rft.volume=2&rft.issue=3&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-006-0026-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - phosphatidylinositol; Protons; Lipids; Pancreatic cancer; Glucose; biomarkers; Lipophilic; Insulin; Models; Blood; N.M.R.; metabolomics; Phospholipids DO - http://dx.doi.org/10.1007/s11306-006-0026-2 ER - TY - CPAPER T1 - Optical Coherence Tomography Signal Enhancement with Gold Nanoshells T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40190772; 4333573 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Agrawal, Anant AU - Lin, Alex AU - Lee, Min-Ho AU - Drezek, Rebekah AU - Pfefer, Josh Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Gold KW - Tomography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40190772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Optical+Coherence+Tomography+Signal+Enhancement+with+Gold+Nanoshells&rft.au=Agrawal%2C+Anant%3BLin%2C+Alex%3BLee%2C+Min-Ho%3BDrezek%2C+Rebekah%3BPfefer%2C+Josh&rft.aulast=Agrawal&rft.aufirst=Anant&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection. AN - 68730360; 16750659 AB - A liquid chromatographic (LC) method for determining 14 sulfonamide (SA) (sulfanilamide, sulfadiazine (SDZ), sulfathiazole, sulfapyridine, sulfamerazine (SMR), sulfamethazine (SMZ), sulfamethizole, sulfamethoxypyridazine, sulfachloropyridazine (SCP), sulfamonomethoxine, sulfadoxine, sulfamethoxazole, sulfadimethoxine (SDM), and sulfaquinoxaline (SQX)) residues in edible catfish, shrimp and salmon tissues was developed and validated at 5, 10 or 20 ng g(-1). The method was then used to determine residues in tissues of catfish, shrimp and salmon dosed with six selected sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine, sulfachloropyridazine, sulfadimethoxine and sulfaquinoxaline). All assays were within U.S. Food and Drug Administration guidelines for recovery and intra-assay variability. The method was developed to determine possible sulfonamide residues in aquacultured catfish, shrimp and salmon produced for food. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Gehring, Theresa A AU - Griffin, Bill AU - Williams, Rod AU - Geiseker, Charles AU - Rushing, Larry G AU - Siitonen, Paul H AD - Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Tgehring@nctr.fda.gov Y1 - 2006/08/18/ PY - 2006 DA - 2006 Aug 18 SP - 132 EP - 138 VL - 840 IS - 2 SN - 1570-0232, 1570-0232 KW - Sulfonamides KW - 0 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Salmon KW - Sulfonamides -- analysis KW - Catfishes KW - Spectrometry, Fluorescence -- methods KW - Drug Residues -- analysis KW - Crustacea KW - Chromatography, High Pressure Liquid -- methods KW - Fish Products -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68730360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Multiresidue+determination+of+sulfonamides+in+edible+catfish%2C+shrimp+and+salmon+tissues+by+high-performance+liquid+chromatography+with+postcolumn+derivatization+and+fluorescence+detection.&rft.au=Gehring%2C+Theresa+A%3BGriffin%2C+Bill%3BWilliams%2C+Rod%3BGeiseker%2C+Charles%3BRushing%2C+Larry+G%3BSiitonen%2C+Paul+H&rft.aulast=Gehring&rft.aufirst=Theresa&rft.date=2006-08-18&rft.volume=840&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-27 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Popcorn worker's lung: in vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine. AN - 68703627; 16545411 AB - Workers who inhale microwave popcorn butter flavorings experience decrements in lung function and can develop clinical bronchiolitis obliterans, i.e., "popcorn worker's lung" (Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E.J., Enright, P.L., 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347, 330-338.). In a rat inhalation model, vapors of an artificial butter flavoring damaged the epithelium of the upper and lower airways (Hubbs, A.F., Battelli, L.A., Goldsmith, W.T., Porter, D.W., Frazer, D., Friend, S., Schwegler-Berry, D., Mercer, R.R., Reynolds, J.S., Grote, A., Castranova, V., Kullman, G., Fedan, J.S., Dowdy, J., Jones, W.G., 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185, 128-135.). Diacetyl, a butter flavoring component, is a major volatile ketone in the popcorn-processing workplace. We investigated the effects of diacetyl on epithelium of guinea pig isolated airway preparations and the effects of diacetyl in vitro on reactivity to bronchoactive agents. In the isolated, perfused trachea preparation, diacetyl added to the intraluminal (mucosal) bath elicited responses that began with contraction (threshold ca. 3 mM) and ended with relaxation. After a 4-h incubation with intraluminal diacetyl (3 mM), contractions to extraluminal (serosal) methacholine (MCh) were slightly increased; however, sensitivity to intraluminally (mucosally) applied MCh was increased by 10-fold. Relaxation responses of MCh (3 x 10(-7) M)-contracted tracheas to extraluminally applied terbutaline and intraluminally applied 120 mM KCl, to evoke epithelium-derived relaxing factor release, were unaffected by diacetyl. Exposure of the tracheal epithelium in Ussing chambers to diacetyl decreased transepithelial potential difference and resistance. These findings suggest that diacetyl exposure compromised epithelial barrier function, leading to hyperreactivity to mucosally applied MCh. The respiratory epithelium appears to serve as an initial target for the toxic effects of diacetyl in the airways. JF - Toxicology and applied pharmacology AU - Fedan, J S AU - Dowdy, J A AU - Fedan, K B AU - Hubbs, A F AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. jsf2@cdc.gov Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 17 EP - 22 VL - 215 IS - 1 SN - 0041-008X, 0041-008X KW - Flavoring Agents KW - 0 KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Butter KW - 8029-34-3 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Trachea -- drug effects KW - Occupational Exposure KW - Methacholine Chloride -- pharmacology KW - Flavoring Agents -- toxicity KW - Diacetyl -- toxicity KW - Lung -- drug effects KW - Food Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Popcorn+worker%27s+lung%3A+in+vitro+exposure+to+diacetyl%2C+an+ingredient+in+microwave+popcorn+butter+flavoring%2C+increases+reactivity+to+methacholine.&rft.au=Fedan%2C+J+S%3BDowdy%2C+J+A%3BFedan%2C+K+B%3BHubbs%2C+A+F&rft.aulast=Fedan&rft.aufirst=J&rft.date=2006-08-15&rft.volume=215&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-20 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - A Theory-Based, Tailored, Interactive Intervention Directed at MSM who Meet Sexual Partners through Internet Chat Sites: Effective for MSM who Practice UAI with Casual Partners T2 - XVI International AIDS Conference (AIDS 2006) AN - 40166790; 4314351 JF - XVI International AIDS Conference (AIDS 2006) AU - Harterink, P AU - Hospers, H AU - Vriens, P AU - Kok, G AU - De Zwart, O Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Internet KW - Sexual partners KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40166790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=A+Theory-Based%2C+Tailored%2C+Interactive+Intervention+Directed+at+MSM+who+Meet+Sexual+Partners+through+Internet+Chat+Sites%3A+Effective+for+MSM+who+Practice+UAI+with+Casual+Partners&rft.au=Chearwae%2C+Wanida%3BShukla%2C+Suneet%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Chearwae&rft.aufirst=Wanida&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaboration with Arab and Muslim-Americans to Break the Silence Surrounding HIV/AIDS T2 - XVI International AIDS Conference (AIDS 2006) AN - 40166548; 4314584 JF - XVI International AIDS Conference (AIDS 2006) AU - Gomez, M AU - Samuels-Atse, S Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40166548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Collaboration+with+Arab+and+Muslim-Americans+to+Break+the+Silence+Surrounding+HIV%2FAIDS&rft.au=Gomez%2C+M%3BSamuels-Atse%2C+S&rft.aulast=Gomez&rft.aufirst=M&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loop Deletions in gp120 Expose the CD4 Binding Site for Improved Binding of 1b12 and F105 Antibodies T2 - XVI International AIDS Conference (AIDS 2006) AN - 40150157; 4314435 JF - XVI International AIDS Conference (AIDS 2006) AU - Berkower, I AU - Ni, Y. AU - Patel, C AU - Spadaccini, A Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Antibodies KW - Deletion KW - CD4 antigen KW - Glycoprotein gp120 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Loop+Deletions+in+gp120+Expose+the+CD4+Binding+Site+for+Improved+Binding+of+1b12+and+F105+Antibodies&rft.au=Berkower%2C+I%3BNi%2C+Y.%3BPatel%2C+C%3BSpadaccini%2C+A&rft.aulast=Berkower&rft.aufirst=I&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells. AN - 68940582; 17031537 AB - Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are a new class of oral drugs designed to treat insulin-resistant diabetes (i.e., type 2 diabetes). However, troglitazone, the first compound in the class approved by the US Food and Drug Administration (FDA) in 1997 was found to be hepatotoxic and was withdrawn from the market after reports of severe liver failure. The mechanism of PPAR gamma agonist-induced hepatotoxicity remains unknown. In this study, we examined the hepatotoxic effects of five PPAR gamma agonists (ciglitazone, pioglitazone, rosiglitazone, troglitazone, and JTT-501) on rat primary hepatocytes and human HepG2 cells. We also compared the gene expression profiles of rat primary hepatocytes after exposure to PPAR gamma agonists by using the Rat Genome Survey Microarray system from Applied Biosystems in order to understand the mechanisms of hepatotoxicities induced by PPARgamma agonists. Consistent with the hepatotoxicity data, our results demonstrate that the gene expression profiles affected by troglitazone and ciglitazone can be clearly distinguished from those by pioglitazone and rosiglitazone. Genes that are differentially expressed between the more toxic troglitazone/ciglitazone group and the less toxic rosiglitazone/pioglitazone group are involved in necrotic, apoptotic, and cell proliferative pathways. The five compounds were also clustered based on a set of molecular descriptors. The clustering based on chemical structural information is in good agreement with the clustering of compounds based on cytotoxicity or gene expression data, indicating a strong relationship between chemical structure and biological endpoints. Our work suggests that microarray analysis together with toxicological observations can be used to rank drugs for hepatotoxicity and to evaluate the safety of new compounds. JF - Molecular diversity AU - Guo, Lei AU - Zhang, Lu AU - Sun, Yongming AU - Muskhelishvili, Levan AU - Blann, Ernice AU - Dial, Stacey AU - Shi, Leming AU - Schroth, Gary AU - Dragan, Yvonne P AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. lei.guo@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 349 EP - 360 VL - 10 IS - 3 SN - 1381-1991, 1381-1991 KW - Chromans KW - 0 KW - Hypoglycemic Agents KW - PPAR gamma KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - troglitazone KW - I66ZZ0ZN0E KW - ciglitazone KW - U8QXS1WU8G KW - pioglitazone KW - X4OV71U42S KW - Index Medicus KW - Animals KW - Chromans -- toxicity KW - Liver Neoplasms -- metabolism KW - Humans KW - Transcription, Genetic KW - Cells, Cultured -- drug effects KW - Thiazolidinediones -- toxicity KW - Rats KW - Carcinoma, Hepatocellular -- metabolism KW - Rats, Sprague-Dawley KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Cluster Analysis KW - Gene Expression Profiling KW - Hepatocytes -- drug effects KW - Hypoglycemic Agents -- toxicity KW - Gene Expression Regulation -- drug effects KW - PPAR gamma -- agonists KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68940582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+diversity&rft.atitle=Differences+in+hepatotoxicity+and+gene+expression+profiles+by+anti-diabetic+PPAR+gamma+agonists+on+rat+primary+hepatocytes+and+human+HepG2+cells.&rft.au=Guo%2C+Lei%3BZhang%2C+Lu%3BSun%2C+Yongming%3BMuskhelishvili%2C+Levan%3BBlann%2C+Ernice%3BDial%2C+Stacey%3BShi%2C+Leming%3BSchroth%2C+Gary%3BDragan%2C+Yvonne+P&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2006-08-01&rft.volume=10&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Molecular+diversity&rft.issn=13811991&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-25 N1 - Date created - 2006-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A federal perspective on the abuse of prescription stimulants. AN - 68869678; 16986454 JF - Pediatric annals AU - Clark, H Westley AU - Bizzell, Anton C AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD 20857, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 594 EP - 597 VL - 35 IS - 8 SN - 0090-4481, 0090-4481 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Child KW - Adolescent KW - United States -- epidemiology KW - Central Nervous System Stimulants -- administration & dosage KW - Substance-Related Disorders -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68869678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+annals&rft.atitle=A+federal+perspective+on+the+abuse+of+prescription+stimulants.&rft.au=Clark%2C+H+Westley%3BBizzell%2C+Anton+C&rft.aulast=Clark&rft.aufirst=H&rft.date=2006-08-01&rft.volume=35&rft.issue=8&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-006-9117-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anisotropic imaging performance in indirect x-ray imaging detectors. AN - 68845896; 16967568 AB - We report on the variability in imaging system performance due to oblique x-ray incidence, and the associated transport of quanta (both x rays and optical photons) through the phosphor, in columnar indirect digital detectors. The analysis uses MANTIS, a combined x-ray, electron, and optical Monte Carlo transport code freely available. We describe the main features of the simulation method and provide some validation of the phosphor screen models considered in this work. We report x-ray and electron three-dimensional energy deposition distributions and point-response functions (PRFs), including optical spread in columnar phosphor screens of thickness 100 and 500 microm, for 19, 39, 59, and 79 keV monoenergetic x-ray beams incident at 0 degrees, 10 degrees, and 15 degrees. In addition, we present pulse-height spectra for the same phosphor thickness, x-ray energies, and angles of incidence. Our results suggest that the PRF due to the phosphor blur is highly nonsymmetrical, and that the resolution properties of a columnar screen in a tomographic, or tomosynthetic imaging system varies significantly with the angle of x-ray incidence. Moreover, we find that the noise due to the variability in the number of light photons detected per primary x-ray interaction, summarized in the information or Swank factor, is somewhat independent of thickness and incidence angle of the x-ray beam. Our results also suggest that the anisotropy in the PRF is not less in screens with absorptive backings, while the noise introduced by variations in the gain and optical transport is larger. Predictions from MANTIS, after additional validation, can provide the needed understanding of the extent of such variations, and eventually, lead to the incorporation of the changes in imaging performance with incidence angle into the reconstruction algorithms for volumetric x-ray imaging systems. JF - Medical physics AU - Badano, Aldo AU - Kyprianou, Iacovos S AU - Sempau, Josep AD - Division of Imaging and Applied Mathematics, Office of Science and Engineering Labs, Center for Devices and Radiological Health, U.S. Food & Drug Administration, 12720 Twinbrook Parkway, Rockville, Maryland 20857, USA. aldo.badano@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 2698 EP - 2713 VL - 33 IS - 8 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Equipment Design KW - Computer Simulation KW - Anisotropy KW - Reproducibility of Results KW - Equipment Failure Analysis KW - Monte Carlo Method KW - Image Interpretation, Computer-Assisted -- methods KW - Transducers KW - Radiographic Image Enhancement -- instrumentation KW - Radiographic Image Enhancement -- methods KW - Models, Statistical KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Anisotropic+imaging+performance+in+indirect+x-ray+imaging+detectors.&rft.au=Badano%2C+Aldo%3BKyprianou%2C+Iacovos+S%3BSempau%2C+Josep&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2006-08-01&rft.volume=33&rft.issue=8&rft.spage=2698&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-09-12 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 ER - TY - JOUR T1 - Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth. AN - 68792175; 16606643 AB - To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1,712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP). The highest prenatal concentrations of p,p'-DDE (>or=60 microg/l), as compared with the lowest (<15 microg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1,540], 4 years [-1.14 cm (0.56), n = 1,289], and 7 years [-2.19 (0.46), n = 1,371]. Among subjects in lower categories of exposure no association was observed. The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected. JF - International journal of epidemiology AU - Ribas-Fitó, Núria AU - Gladen, Beth C AU - Brock, John W AU - Klebanoff, Mark A AU - Longnecker, Matthew P AD - Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA. nribas@imim.es Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 853 EP - 858 VL - 35 IS - 4 SN - 0300-5771, 0300-5771 KW - Environmental Pollutants KW - 0 KW - Insecticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Index Medicus KW - Sex Factors KW - Humans KW - Linear Models KW - African Americans KW - Child KW - Maternal Exposure KW - Pregnancy KW - Child, Preschool KW - Infant KW - Prospective Studies KW - European Continental Ancestry Group KW - Adult KW - Case-Control Studies KW - Body Height -- drug effects KW - Female KW - Male KW - Insecticides -- toxicity KW - Environmental Pollutants -- toxicity KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Growth -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68792175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Prenatal+exposure+to+1%2C1-dichloro-2%2C2-bis+%28p-chlorophenyl%29ethylene+%28p%2Cp%27-DDE%29+in+relation+to+child+growth.&rft.au=Ribas-Fit%C3%B3%2C+N%C3%BAria%3BGladen%2C+Beth+C%3BBrock%2C+John+W%3BKlebanoff%2C+Mark+A%3BLongnecker%2C+Matthew+P&rft.aulast=Ribas-Fit%C3%B3&rft.aufirst=N%C3%BAria&rft.date=2006-08-01&rft.volume=35&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-13 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Epidemiol. 2006 Aug;35(4):858-61 [16847017] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. AN - 68788344; 16930414 AB - Induction of the immediate early gene protein product Fos has been used extensively to assess neural activation in the striatum after repeated cocaine administration to rats in their home cages but rarely after repeated administration outside the home cage, which produces more robust locomotor sensitization. In the present study, we found cocaine-induced Fos expression in nucleus accumbens, but not caudate-putamen, was enhanced 1 and 6 months after repeated drug administration in locomotor activity chambers. Double-labelling of Fos protein and enkephalin mRNA indicated that Fos expression in nucleus accumbens was enhanced in enkephalin-positive, but not enkephalin-negative, medium spiny neurons. In contrast, cocaine-induced Fos expression was absent altogether in nucleus accumbens and unaltered in caudate-putamen 1 month after repeated cocaine administration in the home cage. As cocaine-induced locomotor activity was also enhanced 1 and 6 months after repeated cocaine administration in locomotor activity chambers, we wanted to confirm that neuronal activity in nucleus accumbens mediates cocaine-induced locomotor activity using our particular treatment regimen. Bilateral infusions of the GABA agonists baclofen and muscimol (1 microg/side) into nucleus accumbens of sensitized rats blocked cocaine-induced Fos expression and locomotor activity. Thus, while neuronal activity in both D1- and D2-type neurons in nucleus accumbens can mediate acute cocaine-induced locomotor activity, the enhanced activation of enkephalinergic D2-type neurons suggests that these latter neurons mediate the enhancement of cocaine-induced locomotor activity for up to 6 months after repeated drug administration outside the home cage. JF - The European journal of neuroscience AU - Hope, Bruce T AU - Simmons, Danielle E AU - Mitchell, Tim B AU - Kreuter, Justin D AU - Mattson, Brandi J AD - Behavioural Neuroscience Branch, Intramural Research Program, The National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. bhope@intra.nida.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 867 EP - 875 VL - 24 IS - 3 SN - 0953-816X, 0953-816X KW - Dopamine Uptake Inhibitors KW - 0 KW - Enkephalins KW - GABA Agonists KW - Proto-Oncogene Proteins c-fos KW - Receptors, Dopamine D2 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Drug Administration Schedule KW - Dopamine Uptake Inhibitors -- adverse effects KW - Disease Models, Animal KW - Drug Interactions -- physiology KW - Receptors, Dopamine D2 -- metabolism KW - Up-Regulation -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Neostriatum -- metabolism KW - Time KW - GABA Agonists -- pharmacology KW - Up-Regulation -- drug effects KW - Neostriatum -- drug effects KW - Receptors, Dopamine D2 -- drug effects KW - Enkephalins -- metabolism KW - Gene Expression -- physiology KW - Time Factors KW - Male KW - Proto-Oncogene Proteins c-fos -- drug effects KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Nucleus Accumbens -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Nucleus Accumbens -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Cocaine-induced+locomotor+activity+and+Fos+expression+in+nucleus+accumbens+are+sensitized+for+6+months+after+repeated+cocaine+administration+outside+the+home+cage.&rft.au=Hope%2C+Bruce+T%3BSimmons%2C+Danielle+E%3BMitchell%2C+Tim+B%3BKreuter%2C+Justin+D%3BMattson%2C+Brandi+J&rft.aulast=Hope&rft.aufirst=Bruce&rft.date=2006-08-01&rft.volume=24&rft.issue=3&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humans. AN - 68788151; 16934071 AB - Cross-species infection of humans with simian foamy virus (SFV) has been reported in European and North American nonhuman primate (NHP) handlers, primarily due to wound injuries involving infected animals in research centers and zoos. Additionally, African hunters have been found to be infected with SFV by exposure to body fluids, blood, or tissues of infected NHPs in the wild. The persistence of infectious virus in peripheral blood mononuclear cells (PBMNC) and the recent identification of some infected blood donors has raised safety concerns regarding potential virus transmission by blood transfusion. SFV infection by blood transfusion was evaluated by whole-blood transfer from two naturally-infected rhesus macaques (designated as D1 and D2) to retrovirus-free monkeys. Blood from D1 was transfused to two recipient monkeys R1 and R2 and from D2 to monkeys R3 and R4. Virus transmission was evaluated by immunoassays, polymerase chain reaction assays, and coculture of PBMNC for SFV isolation. SFV infection was seen in R1 and R2 based on development of virus-specific antibodies, identification of SFV sequences in monkey PBMNC, and isolation of infectious virus from PBMNC. Furthermore, both R1 and R2 remained SFV-positive at about 1 year after transfusion, which was the last time tested. No evidence of SFV infection was seen in R3 and R4. SFV transmission in macaques occurred by transfusion of blood from one of two infected donor animals. These results indicate the potential of SFV transfusion transmission in humans, which may depend on virus-specific or donor-related factors. JF - Transfusion AU - Khan, Arifa S AU - Kumar, Dhanya AD - Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA. arifa.khan@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1352 EP - 1359 VL - 46 IS - 8 SN - 0041-1132, 0041-1132 KW - Antibodies, Viral KW - 0 KW - RNA, Viral KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Coculture Techniques KW - Animals, Zoo -- blood KW - Humans KW - Disease Models, Animal KW - Leukocytes, Mononuclear -- immunology KW - Antibodies, Viral -- immunology KW - Antibodies, Viral -- blood KW - Animals, Zoo -- virology KW - Leukocytes, Mononuclear -- virology KW - Cells, Cultured KW - Macaca mulatta KW - RNA, Viral -- blood KW - Spumavirus -- isolation & purification KW - Retroviridae Infections -- immunology KW - Blood Transfusion -- adverse effects KW - Zoonoses -- virology KW - Retroviridae Infections -- transmission KW - Retroviridae Infections -- blood KW - Spumavirus -- immunology KW - Zoonoses -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Simian+foamy+virus+infection+by+whole-blood+transfer+in+rhesus+macaques%3A+potential+for+transfusion+transmission+in+humans.&rft.au=Khan%2C+Arifa+S%3BKumar%2C+Dhanya&rft.aulast=Khan&rft.aufirst=Arifa&rft.date=2006-08-01&rft.volume=46&rft.issue=8&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-22 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Transfusion. 2007 May;47(5):949-50 [17465966] Transfusion. 2006 Aug;46(8):1276-8 [16934059] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin. AN - 68782130; 16928820 AB - Curcumin (curcumin I), demethoxycurcumin (curcumin II), and bisdemethoxycurcumin (curcumin III) are the major forms of curcuminoids found in the turmeric powder, which exhibit anticancer, antioxidant, and anti-inflammatory activities. In this study, we evaluated the ability of purified curcuminoids to modulate the function of either the wild-type 482R or the mutant 482T ABCG2 transporter stably expressed in HEK293 cells and drug-selected MCF-7 FLV1000 and MCF-7 AdVp3000 cells. Curcuminoids inhibited the transport of mitoxantrone and pheophorbide a from ABCG2-expressing cells. However, both cytotoxicity and [(3)H]curcumin I accumulation assays showed that curcuminoids are not transported by ABCG2. Nontoxic concentration of curcumin I, II, and III sensitized the ABCG2-expressing cells to mitoxantrone, topotecan, SN-38, and doxorubicin. This reversal was not due to reduced expression because ABCG2 protein levels were unaltered by treatment with 10 mumol/L curcuminoids for 72 hours. Curcumin I, II, and III stimulated (2.4- to 3.3-fold) ABCG2-mediated ATP hydrolysis and the IC(50)s were in the range of 7.5 to 18 nmol/L, suggesting a high affinity of curcuminoids for ABCG2. Curcuminoids also inhibited the photolabeling of ABCG2 with [(125)I]iodoarylazidoprazosin and [(3)H]azidopine as well as the transport of these two substrates in ABCG2-expressing cells. Curcuminoids did not inhibit the binding of [alpha-(32)P]8-azidoATP to ABCG2, suggesting that they do not interact with the ATP-binding site of the transporter. Collectively, these data show that, among curcuminoids, curcumin I is the most potent modulator of ABCG2 and thus should be considered as a treatment to increase the efficacy of conventional chemotherapeutic drugs. JF - Molecular cancer therapeutics AU - Chearwae, Wanida AU - Shukla, Suneet AU - Limtrakul, Pornngarm AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute/NIH, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1995 EP - 2006 VL - 5 IS - 8 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Anticarcinogenic Agents KW - Azides KW - Dihydropyridines KW - Neoplasm Proteins KW - Chlorophyll KW - 1406-65-1 KW - 8-azidoadenosine 5'-triphosphate KW - 53696-59-6 KW - azidopine KW - 63XR70204A KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - azidoprazosin KW - 90990-97-9 KW - Mitoxantrone KW - BZ114NVM5P KW - pheophorbide a KW - IA2WNI2HO2 KW - Curcumin KW - IT942ZTH98 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Prazosin -- metabolism KW - Prazosin -- analogs & derivatives KW - Chlorophyll -- metabolism KW - Mitoxantrone -- metabolism KW - Humans KW - Biological Transport KW - Dihydropyridines -- metabolism KW - Hydrolysis KW - Azides -- metabolism KW - Tumor Cells, Cultured KW - Adenosine Triphosphate -- analogs & derivatives KW - Adenosine Triphosphate -- metabolism KW - Toxicity Tests KW - Chlorophyll -- analogs & derivatives KW - Mutation KW - Neoplasm Proteins -- drug effects KW - ATP-Binding Cassette Transporters -- drug effects KW - Curcumin -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - Anticarcinogenic Agents -- pharmacology KW - ATP-Binding Cassette Transporters -- genetics KW - Drug Resistance, Neoplasm KW - Neoplasm Proteins -- metabolism KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68782130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Modulation+of+the+function+of+the+multidrug+resistance-linked+ATP-binding+cassette+transporter+ABCG2+by+the+cancer+chemopreventive+agent+curcumin.&rft.au=Chearwae%2C+Wanida%3BShukla%2C+Suneet%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Chearwae&rft.aufirst=Wanida&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interpreting periodic lung function tests in individuals: the relationship between 1- to 5-year and long-term FEV1 changes. AN - 68742922; 16899850 AB - Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV(1) declines. We sought to describe the relationship between FEV(1) changes over 1 to 5 years and FEV(1) declines over longer terms, using 21,821 test results from 1,884 workers who participated in an annual health monitoring program at a chemical plant between 1973 and 2003. Test results from workers with five or more valid results over > or = 10 years were included in our analysis (mean initial worker age, 35 years; range, 18 to 62 years; 91% male; 35% current smokers and 41% nonsmokers). For each worker, long-term FEV(1) slopes (milliliters per year) were calculated by simple linear regression using all available results and compared to changes in FEV(1) between two tests over 1 to 5 years, expressed in both milliliters and percentage of initial value. Long-term (mean, 18 years; range, 10 to 30 years) slopes averaged - 29.1 mL/yr (- 27, - 29, and - 37 mL/yr for male never-smokers, former smokers, and current smokers, and - 20, - 26, and - 27 mL/yr for female never-smokers, former smokers, and current smokers, respectively). Excessive short-term and long-term declines were defined by lower fifth percentile values. Individuals with abnormal short-term declines were found to be 3 to 18 times more likely to ultimately show excessive long-term declines; with the strength of the association increasing with the length of the short-term testing interval. Better test operating characteristics resulted if abnormal short-term FEV(1) change was based on percentage change (ie, percentage per year) rather than absolute change (ie, milliliters per year). Our findings provide guidance for interpreting periodic spirometry results from individuals exposed to respiratory hazards. JF - Chest AU - Wang, Mei Lin AU - Avashia, Bipin H AU - Petsonk, Edward L AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 493 EP - 499 VL - 130 IS - 2 SN - 0012-3692, 0012-3692 KW - Abridged Index Medicus KW - Index Medicus KW - Spirometry KW - Reproducibility of Results KW - Humans KW - Adult KW - Disease Progression KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Lung Diseases -- diagnosis KW - Occupational Diseases -- physiopathology KW - Lung Diseases -- physiopathology KW - Forced Expiratory Volume -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68742922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Interpreting+periodic+lung+function+tests+in+individuals%3A+the+relationship+between+1-+to+5-year+and+long-term+FEV1+changes.&rft.au=Wang%2C+Mei+Lin%3BAvashia%2C+Bipin+H%3BPetsonk%2C+Edward+L&rft.aulast=Wang&rft.aufirst=Mei&rft.date=2006-08-01&rft.volume=130&rft.issue=2&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The medical response to trench nephritis in World War One. AN - 68733634; 16820794 AB - Around the 90-year anniversary of the Battle of the Somme, it is important to remember the international effort that went into responding to the new diseases, which appeared during the First World War, such as trench nephritis. This condition arose among soldiers in spring 1915, characterized by breathlessness, swelling of the face or legs, headache, sore throat, and the presence of albumin and renal casts in urine. It was speedily investigated by the military-medical authorities. There was debate over whether it was new condition or streptococcal nephritis, and the experts agreed that it was a new condition. The major etiologies proposed were infection, exposure, and diet (including poisons). Research pointed to the origin of the disease as being infective rather than toxic, but no definite cause was discovered. A number of labels were given to the disease, including war nephritis. However, trench nephritis was the one used most widely. Trench nephritis was a serious problem for the Allies, leading to 35 000 casualties in the British and 2000 in the American forces. There were also hundreds of deaths. The condition was treated in line with pre-war regimens designed for acute nephritis. No significant preventative methods were implemented for trench nephritis, as there was no consensus regarding causation. The medical response to trench nephritis was largely ineffective, with medical commentators recognizing that there had been a lack of medical progress. JF - Kidney international AU - Atenstaedt, R L AD - National Public Health Service for Wales and Institute of Medical and Social Care Research (IMSCaR), University of Wales, Bangor, UK. Robert.Atenstaedt@nphs.wales.nhs.uk Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 635 EP - 640 VL - 70 IS - 4 SN - 0085-2538, 0085-2538 KW - Index Medicus KW - History, 20th Century KW - Humans KW - Incidence KW - Europe -- epidemiology KW - Nephritis -- epidemiology KW - Nephritis -- therapy KW - Nephritis -- etiology KW - World War I KW - Military Medicine -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=The+medical+response+to+trench+nephritis+in+World+War+One.&rft.au=Atenstaedt%2C+R+L&rft.aulast=Atenstaedt&rft.aufirst=R&rft.date=2006-08-01&rft.volume=70&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-26 N1 - Date created - 2006-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco use in adult long-term survivors of retinoblastoma. AN - 68719311; 16896033 AB - A significant risk of lung cancer was identified among hereditary, but not nonhereditary, retinoblastoma (Rb) patients. Tobacco use was investigated to determine whether differences in smoking prevalence might explain the lung cancer excess and to characterize smoking patterns in adult survivors of Rb. Subjects were 441 hereditary and 395 nonhereditary 1-year survivors of Rb, age >or=18 years, who responded to a telephone survey about current health behavior, including tobacco use. Response rates were 76% for hereditary and 73% for nonhereditary survivors. We compared patterns and predictors of current tobacco use among hereditary and nonhereditary survivors with other childhood cancer survivor studies and the U.S. population. Hereditary Rb survivors currently smoke cigarettes significantly less frequently than nonhereditary survivors (16. 8% versus 24.3%), although among current smokers, age at smoking initiation (17 years old) and average cigarettes (1.5 packs) smoked daily are similar. Predictors of current and ever cigarette smoking include nonhereditary Rb, older age, being female, less education, and use of other tobacco products. Rb survivors smoke cigarettes significantly less than the U.S. population (rate ratio, 0.63; 95% confidence interval, 0.5-0.8 for males; rate ratio, 0.75; 95% confidence interval, 0.6-0.9 for females), but Rb survivors have comparable smoking rates with other childhood cancer survivors. Smoking did not account for the increased risk of lung cancer among hereditary Rb patients, and this may point to an enhanced sensitivity to the carcinogenic effects of tobacco. Adult survivors of Rb should be encouraged to stop smoking. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Foster, Meredith C AU - Kleinerman, Ruth A AU - Abramson, David H AU - Seddon, Johanna M AU - Tarone, Robert E AU - Tucker, Margaret A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7044, 6120 Executive Boulevard, Rockville, MD 20852, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1464 EP - 1468 VL - 15 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Retinoblastoma -- mortality KW - Retinal Neoplasms -- mortality KW - Retinal Neoplasms -- epidemiology KW - Survivors KW - Smoking -- epidemiology KW - Retinoblastoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68719311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Tobacco+use+in+adult+long-term+survivors+of+retinoblastoma.&rft.au=Foster%2C+Meredith+C%3BKleinerman%2C+Ruth+A%3BAbramson%2C+David+H%3BSeddon%2C+Johanna+M%3BTarone%2C+Robert+E%3BTucker%2C+Margaret+A&rft.aulast=Foster&rft.aufirst=Meredith&rft.date=2006-08-01&rft.volume=15&rft.issue=8&rft.spage=1464&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. AN - 68718683; 16797171 AB - Transdermal drug delivery systems (TDDS), also known as "patches," are dosage forms designed to deliver a therapeutically effective amount of drug across a patient's skin. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. In the Drug Quality Reporting System (DQRS), the United States Food and Drug Administration (FDA) has received numerous reports of "adhesion lacking" for transdermal drug delivery systems. This article provides an overview of types of transdermals, their anatomy, the role of adhesion, the possible adhesion failure modes and how adhesion can be measured. Excerpts from FDA reports on the lack of adhesion of transdermal system products are presented. Pros and cons of in vitro techniques, such as peel adhesion, tack and shear strength, in vivo techniques used to evaluate adhesive properties are discussed. To see a decrease in "adhesion lacking" reports, adhesion needs to become an important design parameter and suitable methods need to be available to assess quality and in vivo performance. This article provides a framework for further discussion and scientific work to improve transdermal adhesive performance. JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V AU - Wokovich, Anna M AU - Prodduturi, Suneela AU - Doub, William H AU - Hussain, Ajaz S AU - Buhse, Lucinda F AD - Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA. anna.wokovich@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1 EP - 8 VL - 64 IS - 1 SN - 0939-6411, 0939-6411 KW - Delayed-Action Preparations KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - United States KW - Chemistry, Pharmaceutical KW - Adverse Drug Reaction Reporting Systems KW - Skin Absorption KW - Humans KW - Safety KW - Quality Control KW - Administration, Cutaneous KW - Technology, Pharmaceutical -- methods KW - Drug Delivery Systems -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68718683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmaceutics+and+biopharmaceutics+%3A+official+journal+of+Arbeitsgemeinschaft+fur+Pharmazeutische+Verfahrenstechnik+e.V&rft.atitle=Transdermal+drug+delivery+system+%28TDDS%29+adhesion+as+a+critical+safety%2C+efficacy+and+quality+attribute.&rft.au=Wokovich%2C+Anna+M%3BProdduturi%2C+Suneela%3BDoub%2C+William+H%3BHussain%2C+Ajaz+S%3BBuhse%2C+Lucinda+F&rft.aulast=Wokovich&rft.aufirst=Anna&rft.date=2006-08-01&rft.volume=64&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmaceutics+and+biopharmaceutics+%3A+official+journal+of+Arbeitsgemeinschaft+fur+Pharmazeutische+Verfahrenstechnik+e.V&rft.issn=09396411&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994. AN - 68706334; 16882527 AB - Volatile organic compounds (VOCs) are present in much higher concentrations indoors, where people spend most of their time, than outdoors and may have adverse health effects. VOCs have been associated with respiratory symptoms, but few studies address objective respiratory end points such as pulmonary function. Blood levels of VOCs may be more indicative of personal exposures than are air concentrations; no studies have addressed their relationship with respiratory outcomes. We examined whether concentrations of 11 VOCs that were commonly identified in blood from a sample of the U.S. population were associated with pulmonary function. We used data from 953 adult participants (20-59 years of age) in the Third National Health and Nutrition Examination Survey (1988-1994) who had VOC blood measures as well as pulmonary function measures. Linear regression models were used to evaluate the relationship between 11 VOCs and measures of pulmonary function. After adjustment for smoking, only 1,4-dichlorobenzene (1,4-DCB) was associated with reduced pulmonary function. Participants in the highest decile of 1,4-DCB concentration had decrements of -153 mL [95% confidence interval (CI) , -297 to -8] in forced expiratory volume in 1 sec and -346 mL/sec (95% CI, -667 to -24) in maximum mid-expiratory flow rate, compared with participants in the lowest decile. Exposure to 1,4-DCB, a VOC related to the use of air fresheners, toilet bowl deodorants, and mothballs, at levels found in the U.S. general population, may result in reduced pulmonary function. This common exposure may have long-term adverse effects on respiratory health. JF - Environmental health perspectives AU - Elliott, Leslie AU - Longnecker, Matthew P AU - Kissling, Grace E AU - London, Stephanie J AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709-2233, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1210 EP - 1214 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Organic Chemicals KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Regression Analysis KW - Humans KW - Adult KW - Middle Aged KW - Forced Expiratory Volume -- physiology KW - Environmental Exposure -- adverse effects KW - United States -- epidemiology KW - Smoking -- epidemiology KW - Male KW - Female KW - Health Surveys KW - Organic Chemicals -- analysis KW - Nutrition Surveys KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68706334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Volatile+organic+compounds+and+pulmonary+function+in+the+Third+National+Health+and+Nutrition+Examination+Survey%2C+1988-1994.&rft.au=Elliott%2C+Leslie%3BLongnecker%2C+Matthew+P%3BKissling%2C+Grace+E%3BLondon%2C+Stephanie+J&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Environ Med. 1995 Jun;52(6):388-95 [7627316] Environ Health Perspect. 2006 Mar;114(3):453-9 [16507471] J Anal Toxicol. 1995 Sep;19(5):323-9 [7500620] BMJ. 1996 Sep 21;313(7059):711-5; discussion 715-6 [8819439] Int Arch Occup Environ Health. 1997;69(2):115-24 [9001918] Arch Environ Health. 1997 Jan-Feb;52(1):26-33 [9039854] Chem Biol Interact. 1997 Jan 24;103(1):17-33 [9051121] AMA Arch Ind Health. 1956 Aug;14(2):138-47 [13353999] Arch Environ Health. 2003 Oct;58(10):633-41 [15562635] Clin Exp Allergy. 1997 Nov;27(11):1270-8 [9420130] Int J Occup Environ Health. 2000 Jan-Mar;6(1):1-8 [10637531] Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):665-73 [10673213] Int J Hyg Environ Health. 2000 Mar;203(1):23-8 [10956586] Arch Environ Health. 2001 Mar-Apr;56(2):157-66 [11339680] Environ Health Perspect. 2002 Aug;110(8):765-70 [12153756] Am J Epidemiol. 2002 Oct 15;156(8):738-46 [12370162] Environ Health Perspect. 2003 Apr;111(4):647-56 [12676630] Thorax. 2003 Nov;58(11):955-60 [14586048] Thorax. 2004 Sep;59(9):746-51 [15333849] Environ Res. 1987 Aug;43(2):290-307 [3608934] Am J Public Health. 1989 Mar;79(3):340-9 [2916724] Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):751-4 [2008987] Arch Environ Health. 1992 Jan-Feb;47(1):39-44 [1540001] Anal Chem. 1992 May 1;64(9):1021-9 [1590585] Environ Health Perspect. 1991 Nov;95:7-13 [1821381] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):157-92 [1824315] Clin Chem. 1994 Jul;40(7 Pt 2):1376-84 [8013122] Clin Chem. 1994 Jul;40(7 Pt 2):1401-4 [8013127] Environ Health Perspect. 2005 Mar;113(3):342-9 [15743726] Environ Health Perspect. 2005 Nov;113(11):1542-8 [16263509] Arch Environ Health. 1995 Jul-Aug;50(4):277-80 [7677426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to cyanazine in the agricultural health study. AN - 68703795; 16882534 AB - Cyanazine is a common pesticide used frequently in the United States during the 1980s and 1990s. Animal and human studies have suggested that triazines may be carcinogenic, but results have been mixed. We evaluated cancer incidence in cyanazine-exposed pesticide applicators among the 57,311 licensed pesticide applicators in the Agricultural Health Study (AHS). We obtained detailed pesticide exposure information from a self-administered questionnaire completed at enrollment (1993-1997). Cancer incidence was followed through January 2002. Over half of cyanazine-exposed applicators had >or=6 years of exposure at enrollment, and approximately 85% had begun using cyanazine before the 1990s. We used adjusted Poisson regression to calculate rate ratios (RRs) and 95% confidence intervals (CIs) of multiple cancer sites among cyanazine-exposed applicators. We calculated ptrend values, and all statistical tests were two-sided. Two exposure metrics were used: tertiles of lifetime days of exposure (LD) and intensity-weighted LD. A total of 20,824 cancer-free AHS applicators reported ever using cyanazine at enrollment. Cancer incidence comparisons between applicators with the lowest cyanazine exposure and those with the highest exposure yielded the following for the LD metric: all cancers, RR=0.99 (95% CI, 0.80-1.24); prostate cancer, RR=1.23 (95% CI, 0.87-1.70); all lymphohematopoietic cancers, RR=0.92 (95% CI, 0.50-1.72); non-Hodgkin lymphoma, RR=1.25 (95% CI, 0.47-3.35); lung cancer, RR=0.52 (95% CI, 0.22-1.25). We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. The number of sites was small for certain cancers, limiting any conclusion with regard to ovarian, breast, and some other cancers. JF - Environmental health perspectives AU - Lynch, Shannon M AU - Rusiecki, Jennifer A AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Lubin, Jay AU - Sandler, Dale AU - Hoppin, Jane A AU - Lynch, Charles F AU - Alavanja, Michael C R AD - Clinical and Genetic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1248 EP - 1252 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Herbicides KW - 0 KW - Triazines KW - cyanazine KW - W34C4P18WD KW - Index Medicus KW - Prostatic Neoplasms -- epidemiology KW - Humans KW - Aged KW - Poisson Distribution KW - Risk Assessment KW - Colonic Neoplasms -- epidemiology KW - Prospective Studies KW - Lung Neoplasms -- epidemiology KW - Lymphoma -- epidemiology KW - Adult KW - Cohort Studies KW - Follow-Up Studies KW - Middle Aged KW - Hematologic Neoplasms -- epidemiology KW - Female KW - Male KW - Herbicides -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Triazines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+cyanazine+in+the+agricultural+health+study.&rft.au=Lynch%2C+Shannon+M%3BRusiecki%2C+Jennifer+A%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay%3BSandler%2C+Dale%3BHoppin%2C+Jane+A%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+C+R&rft.aulast=Lynch&rft.aufirst=Shannon&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2004 Sep 15;96(18):1375-82 [15367570] Occup Environ Med. 2003 Sep;60(9):E11 [12937207] Lancet. 1985 Jun 1;1(8440):1277-8 [2860478] JAMA. 1986 Sep 5;256(9):1141-7 [3801091] Cancer Res. 1987 Nov 1;47(21):5777-81 [3664481] Scand J Work Environ Health. 1989 Feb;15(1):47-53 [2922589] J Environ Sci Health B. 1990 Feb;25(1):1-29 [2187918] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Am J Ind Med. 1990;18(3):295-301 [2220834] Epidemiology. 1993 Jan;4(1):55-62 [8420582] Mutat Res. 1994 Jun;321(4):219-28 [7515160] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Environ Health Perspect. 1997 Nov;105(11):1222-7 [9370519] Environ Res. 1999 Feb;80(2 Pt 1):172-9 [10092410] Am J Epidemiol. 2005 Jan 15;161(2):121-35 [15632262] J Appl Toxicol. 2005 May-Jun;25(3):179-83 [15856525] Arch Environ Contam Toxicol. 2002 Jan;42(1):127-36 [11706377] J Toxicol Environ Health A. 2000 Aug 25;60(8):567-86 [10983523] J Environ Qual. 2001 May-Jun;30(3):831-45 [11401272] Mutat Res. 2001 Jun 27;493(1-2):1-10 [11516710] J Environ Qual. 2001 Nov-Dec;30(6):2120-6 [11790022] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] J Occup Environ Med. 2002 Nov;44(11):1048-58 [12448356] J Toxicol Environ Health A. 2003 Mar 28;66(6):501-17 [12712593] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Occup Environ Med. 2004 Nov;61(11):945-51 [15477289] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phorate exposure and incidence of cancer in the agricultural health study. AN - 68702558; 16882526 AB - We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS). This finding, together with findings of associations between other organophosphate pesticides and cancer more broadly, prompted us to examine phorate exposure and overall cancer incidence in the AHS. Adding 3 years of follow-up and using more detailed exposure information allowed us to see whether the prostate cancer finding held. The AHS is a prospective study of licensed restricted-use pesticide applicators from North Carolina and Iowa. To our knowledge, this is the largest examination of workers occupationally exposed to phorate. Pesticide exposure and other information was collected using two self-administered questionnaires completed from 1993 to 1997. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI), adjusting for potential confounders. Phorate use was not related to the incidence of all cancers combined or to any individual cancer, although we had insufficient numbers to study non-Hodgkin lymphoma or leukemia, which have been linked to organophosphates in other studies. Although prostate cancer risk was not significantly related to phorate use overall or among those without a family history, the risk tended to increase among applicators with a family history of prostate cancer. The interaction RR was 1.53 (95% CI, 0.99-2.37). The observed statistical interaction suggests a gene-environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible. JF - Environmental health perspectives AU - Mahajan, Rajeev AU - Bonner, Matthew R AU - Hoppin, Jane A AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1205 EP - 1209 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Insecticides KW - 0 KW - Phorate KW - 3W54X3W9IV KW - Index Medicus KW - Socioeconomic Factors KW - Zea mays KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - North Carolina -- epidemiology KW - Alcohol Drinking -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Insecticides -- adverse effects KW - Prostatic Neoplasms -- epidemiology KW - Agricultural Workers' Diseases -- epidemiology KW - Phorate -- adverse effects KW - Occupational Exposure -- adverse effects KW - Insecticides -- analysis KW - Phorate -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68702558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Multiresidue+determination+of+sulfonamides+in+edible+catfish%2C+shrimp+and+salmon+tissues+by+high-performance+liquid+chromatography+with+postcolumn+derivatization+and+fluorescence+detection.&rft.au=Gehring%2C+Theresa+A%3BGriffin%2C+Bill%3BWilliams%2C+Rod%3BGeiseker%2C+Charles%3BRushing%2C+Larry+G%3BSiitonen%2C+Paul+H&rft.aulast=Gehring&rft.aufirst=Theresa&rft.date=2006-08-18&rft.volume=840&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Feb 7;143(1):1-118 [10675783] Int Arch Occup Environ Health. 2004 Nov;77(8):559-70 [15688248] Drug Metab Dispos. 2001 Sep;29(9):1201-4 [11502728] J Pharmacol Exp Ther. 2001 Dec;299(3):825-31 [11714865] Int J Occup Med Environ Health. 2001;14(4):339-47 [11885917] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):418-26 [12415490] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Drug Metab Dispos. 2004 Mar;32(3):333-9 [14977868] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Scand J Work Environ Health. 1985 Dec;11(6):397-407 [3912986] Mutat Res. 1986 Aug-Sep;171(2-3):131-8 [3528835] Prostate. 1987;10(1):79-88 [2434937] Mutat Res. 1987 Jul;188(3):241-50 [3600690] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Prostate. 1990;17(4):337-47 [2251225] J Urol. 1991 Nov;146(5):1305-7 [1942282] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] IARC Monogr Eval Carcinog Risks Hum. 1991;53:45-92 [1842588] Am J Epidemiol. 1993 Feb 1;137(3):270-80 [8452135] Arch Environ Health. 1993 Sep-Oct;48(5):353-8 [8215601] J Urol. 1994 Nov;152(5 Pt 1):1484-7; discussion 1487-9 [7933190] J Toxicol Environ Health. 1994 Nov;43(3):271-89 [7966438] Am J Epidemiol. 1995 Apr 15;141(8):732-40 [7535977] Prostate. 1995 Nov;27(5):250-7 [7479392] Br J Urol. 1996 Jan;77(1):6-14 [8653318] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Scand J Work Environ Health. 1996 Aug;22(4):285-93 [8881017] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Urology. 1998 Sep;52(3):441-3 [9730457] J Occup Environ Med. 1999 Apr;41(4):279-88 [10224594] J Toxicol Environ Health B Crit Rev. 1999 Apr-Jun;2(2):161-81 [10230392] Cancer. 1999 Aug 1;86(3):477-83 [10430256] Eur J Cancer. 1999 Feb;35(2):272-7 [10448270] Cancer. 2004 Nov 15;101(10 Suppl):2371-490 [15495199] J Occup Environ Med. 2000 May;42(5):517-25 [10824305] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. AN - 68689331; 16880481 AB - Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression. To examine the relative acute effects of bupropion, sertraline and venlafaxine as adjuncts to mood stabilisers. In a 10-week trial, participants receiving out-patient treatment for bipolar disorder (stratified for rapid cycling) were randomly treated with a flexible dose of one of the antidepressants, or their respective matching placebos, as adjuncts to mood stabilisers. A total of 174 adults with bipolar disorder I, II or not otherwise specified, currently in the depressed phase, were included. All three antidepressants were associated with a similar range of acute response (49-53%) and remission (34-41%). There was a significantly increased risk of switches into hypomania or mania in participants treated with venlafaxine compared with bupropion or sertraline. More caution appears indicated in the use of venlafaxine rather than bupropion or sertraline in the adjunctive treatment of bipolar depression, especially if there is a prior history of rapid cycling. JF - The British journal of psychiatry : the journal of mental science AU - Post, R M AU - Altshuler, L L AU - Leverich, G S AU - Frye, M A AU - Nolen, W A AU - Kupka, R W AU - Suppes, T AU - McElroy, S AU - Keck, P E AU - Denicoff, K D AU - Grunze, H AU - Walden, J AU - Kitchen, C M R AU - Mintz, J AD - Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA. postr@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 124 EP - 131 VL - 189 SN - 0007-1250, 0007-1250 KW - Adjuvants, Pharmaceutic KW - 0 KW - Antidepressive Agents KW - Antidepressive Agents, Second-Generation KW - Cyclohexanols KW - Bupropion KW - 01ZG3TPX31 KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Severity of Illness Index KW - Adjuvants, Pharmaceutic -- adverse effects KW - Double-Blind Method KW - Depressive Disorder -- chemically induced KW - Humans KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Affect KW - Female KW - Male KW - Bipolar Disorder -- drug therapy KW - Bupropion -- adverse effects KW - Bipolar Disorder -- psychology KW - Sertraline -- adverse effects KW - Antidepressive Agents -- adverse effects KW - Cyclohexanols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.atitle=Mood+switch+in+bipolar+depression%3A+comparison+of+adjunctive+venlafaxine%2C+bupropion+and+sertraline.&rft.au=Post%2C+R+M%3BAltshuler%2C+L+L%3BLeverich%2C+G+S%3BFrye%2C+M+A%3BNolen%2C+W+A%3BKupka%2C+R+W%3BSuppes%2C+T%3BMcElroy%2C+S%3BKeck%2C+P+E%3BDenicoff%2C+K+D%3BGrunze%2C+H%3BWalden%2C+J%3BKitchen%2C+C+M+R%3BMintz%2C+J&rft.aulast=Post&rft.aufirst=R&rft.date=2006-08-01&rft.volume=189&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.issn=00071250&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Br J Psychiatry. 2006 Dec;189:569 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trends in cancer risk among people with AIDS in the United States 1980-2002. AN - 68671987; 16868446 AB - People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends. AIDS and cancer registries in 11 US regions (1980-2002) were used to identify cancers in 375 933 people with AIDS. Cancer risk relative to the general population was measured using the standardized incidence ratio (SIR), focusing on the 2 years after AIDS onset for those with AIDS in 1990-1995 and 1996-2002 (HAART era). Time trends were assessed with Poisson regression. Between 1990-1995 and 1996-2002, risk declined for the two major AIDS-defining cancers: Kaposi sarcoma [(KS) n = 5131; SIR, 22 100 and 3640, respectively; P < 0.0001] and non-Hodgkin lymphoma [(NHL) n = 3412; SIR, 53.2 and 22.6, respectively; P < 0.0001]. Declines began in the 1980s, but risk fell sharply in 1996 and was stable thereafter. Risk of cervical cancer did not change (n = 64; SIR, 4.2 and 5.3, respectively; P = 0.33). Among non-AIDS malignancies, lung cancer was most common, but risk declined between 1990-1995 and 1996-2002 (n = 344; SIR, 3.3 and 2.6, respectively; P = 0.02). Risk of Hodgkin lymphoma increased substantially over the 1990-2002 period (n = 149; SIR, 8.1 and 13.6, respectively; P = 0.003). Dramatic declines in KS and NHL were temporally related to improving therapies, especially introduction of HAART, but those with AIDS remain at marked risk. Among non-AIDS-related cancers, a recent increase in Hodgkin lymphoma was observed. JF - AIDS (London, England) AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Goedert, James J AU - Virgo, Phillip AU - McNeel, Timothy S AU - Scoppa, Steven M AU - Biggar, Robert J AU - HIV/AIDS Cancer Match Study AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. engelse@exchange.nih.gov ; HIV/AIDS Cancer Match Study Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1645 EP - 1654 VL - 20 IS - 12 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Lung Neoplasms -- complications KW - Uterine Cervical Neoplasms -- complications KW - Humans KW - Lung Neoplasms -- immunology KW - Hodgkin Disease -- immunology KW - Lymphoma, Non-Hodgkin -- immunology KW - Hodgkin Disease -- epidemiology KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lung Neoplasms -- epidemiology KW - Adult KW - Kidney Neoplasms -- complications KW - Adolescent KW - Sarcoma, Kaposi -- immunology KW - Male KW - Lymphoma, Non-Hodgkin -- complications KW - Kidney Neoplasms -- epidemiology KW - Sarcoma, Kaposi -- epidemiology KW - Sarcoma, Kaposi -- complications KW - Hodgkin Disease -- complications KW - Age Distribution KW - Uterine Cervical Neoplasms -- epidemiology KW - Risk Factors KW - Incidence KW - Middle Aged KW - Uterine Cervical Neoplasms -- immunology KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Kidney Neoplasms -- immunology KW - Acquired Immunodeficiency Syndrome -- complications KW - Neoplasms -- complications KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68671987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Trends+in+cancer+risk+among+people+with+AIDS+in+the+United+States+1980-2002.&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BGoedert%2C+James+J%3BVirgo%2C+Phillip%3BMcNeel%2C+Timothy+S%3BScoppa%2C+Steven+M%3BBiggar%2C+Robert+J%3BHIV%2FAIDS+Cancer+Match+Study&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2006-08-01&rft.volume=20&rft.issue=12&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of surface wipe media for sampling lead on hands. AN - 68666968; 16862713 AB - Hand contamination by toxic agents such as lead presents a potentially significant health hazard to workers if the contamination is transferred to the mouth by food, smoking, or touching the mouth. One method to sample the mass of contamination on hands is to wipe the skin and analyze the wipe media for the analyte. Several commercially available, prewetted wipe media were evaluated and compared. The Palintest and Wash'n Dri media are made of cellulose fiber; the Ghost wipe is made of a nonwoven polyvinyl alcohol fiber. ASTM test method E1792 for surface lead sampling provides some specified minimum requirements and some general, nonspecific criteria that these media should meet. However, no objective determination of the performance or characteristics of these different wiping media were found in the open literature for sampling lead on hands, particularly relating to typical collection efficiency. To test the recovery of lead oxide dust collected from two hands, two different loading levels were used for each wipe medium. Four successive wipes were collected and analyzed individually. The results of this study indicate that only about 52-62% of the total lead loading is recovered with the first wipe, but that up to 75% recovery could be obtained by combining all three successive wipes. This study also describes testing several physical aspects of these wipes that included tensile strength, wetness, and drying rate, which are characteristics that are not specified by ASTM E1792. The results indicate a higher fragility among the cellulosic wipes, less moisture content, and higher drying rates than the Ghost wipe. This information should be helpful when selecting a wipe material that is best suited for an environmental or industrial hygiene surface or skin sampling task and might also be useful for improving such media in the future. JF - Journal of occupational and environmental hygiene AU - Boeniger, Mark AD - National Institute for Occupational Safety and Health, 8380 Jakaro Drive, Cincinnati, OH 45255, USA. mfboeniger@worldnet.att.net Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 428 EP - 434 VL - 3 IS - 8 SN - 1545-9624, 1545-9624 KW - Air Pollutants KW - 0 KW - Dust KW - Oxides KW - Lead KW - 2P299V784P KW - lead oxide KW - 4IN6FN8492 KW - Index Medicus KW - Humans KW - Textiles -- analysis KW - Oxides -- analysis KW - Dust -- analysis KW - Hand KW - Air Pollutants -- analysis KW - Lead -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68666968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=A+comparison+of+surface+wipe+media+for+sampling+lead+on+hands.&rft.au=Boeniger%2C+Mark&rft.aulast=Boeniger&rft.aufirst=Mark&rft.date=2006-08-01&rft.volume=3&rft.issue=8&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited commentary: on the road to improved exposure assessment using geographic information systems. AN - 68655124; 16707652 JF - American journal of epidemiology AU - Ward, Mary H AU - Wartenberg, Daniel AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. wardm@exchange.nih.gov Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 208 EP - 211 VL - 164 IS - 3 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Risk Assessment KW - Epidemiologic Methods KW - Environmental Exposure -- analysis KW - Geographic Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68655124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+on+the+road+to+improved+exposure+assessment+using+geographic+information+systems.&rft.au=Ward%2C+Mary+H%3BWartenberg%2C+Daniel&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-08-01&rft.volume=164&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2006 Aug 1;164(3):200-7 [16754633] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The frequency of workplace exacerbation among health maintenance organisation members with asthma. AN - 68652559; 16601014 AB - Workplace conditions can potentially contribute to the worsening of asthma, yet it is unclear what percentage of adults with asthma experience workplace exacerbation of symptoms. The objective of this investigation was to determine the prevalence of workplace exacerbation of asthma (WEA). Adults with asthma aged 18-44 were enrolled into the baseline survey of a longitudinal study. Members of a health maintenance organisation were considered candidates for participation if they fulfilled membership, diagnostic, and treatment criteria based on automated review of electronic billing, claims, and pharmacy records. Diagnosis and treatment were confirmed by manual review of medical records. A telephone questionnaire was administered. A work related symptom score was assigned to each participant based on responses to questions about work related asthma symptoms, medication use, and symptom triggers. Blinded to participants' answers to these questions, two researchers independently reviewed the self-reported work histories and assigned exposure ratings. A final exposure score was then calculated. Participants with sufficient evidence for work related symptoms and exposure were classified as having WEA. Of the 598 participants with complete data, 557 (93%) were working, and 136 (23%) fulfilled the criteria for WEA. Those with WEA were more likely to be male and to report that they had been bothered by asthma symptoms during the past seven days. Workplace exacerbation of asthma was common in this study population, occurring in over a fifth of these adults with asthma. Physicians should consider that work can contribute to the exacerbation of symptoms when treating adults with asthma. JF - Occupational and environmental medicine AU - Henneberger, P K AU - Derk, S J AU - Sama, S R AU - Boylstein, R J AU - Hoffman, C D AU - Preusse, P A AU - Rosiello, R A AU - Milton, D K AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health/CDC, Morgantown, WV 26501, USA. pkh0@cdc.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 551 EP - 557 VL - 63 IS - 8 KW - Index Medicus KW - Humans KW - Adult KW - Workplace KW - Bias (Epidemiology) KW - Adolescent KW - Male KW - Female KW - Asthma -- etiology KW - Health Maintenance Organizations KW - Occupational Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68652559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=The+frequency+of+workplace+exacerbation+among+health+maintenance+organisation+members+with+asthma.&rft.au=Henneberger%2C+P+K%3BDerk%2C+S+J%3BSama%2C+S+R%3BBoylstein%2C+R+J%3BHoffman%2C+C+D%3BPreusse%2C+P+A%3BRosiello%2C+R+A%3BMilton%2C+D+K&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2006-08-01&rft.volume=63&rft.issue=8&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1993;22 Suppl 2:S57-64 [8132395] Chest. 1993 Sep;104(3):816-20 [8365294] Med J Aust. 1995 Jan 16;162(2):78-81 [7838030] Chest. 1995 Mar;107(3):634-41 [7874929] Chest. 1995 Oct;108(4):1084-117 [7555124] Chest. 1996 Mar;109(3 Suppl):56S-57S [8598157] Chest. 1996 Mar;109(3):688-96 [8617077] Am J Ind Med. 1998 Jan;33(1):1-10 [9408523] Am J Ind Med. 1998 Feb;33(2):114-22 [9438044] West J Med. 1998 Feb;168(2):98-104 [9499743] J Occup Environ Med. 1998 May;40(5):481-91 [9604186] MMWR CDC Surveill Summ. 1999 Jun 25;48(3):1-20 [10421216] Environ Health. 2003 Aug 7;2(1):10 [12952547] Arch Environ Health. 2003 Dec;58(12):781-8 [15859513] Chest. 1999 Dec;116(6):1780-5 [10593805] Am J Epidemiol. 2001 Sep 1;154(5):477-83 [11532790] Int J Occup Environ Health. 2002 Oct-Dec;8(4):291-6 [12412844] Am J Respir Crit Care Med. 2003 Mar 1;167(5):787-97 [12598220] Occup Environ Med. 2004 Jun;61(6):512-7 [15150390] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Chest. 1987 Oct;92(4):613-7 [2958247] Chest. 1990 Nov;98(5 Suppl):148S-161S [2226002] J Clin Epidemiol. 1992 May;45(5):461-72 [1588352] Eur Respir J. 1994 May;7(5):954-60 [8050554] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bovine kidney tissue/biological fluid correlation for penicillin. AN - 68650896; 16846467 AB - Penicillin is one of the most commonly misused drugs in steers and dairy cows. In the US, at slaughter the tolerance is 50 ng/g in kidney and other edible tissues. If the tolerance is exceeded, the carcass may not be used for human food. A preslaughter test for penicillin in an easily accessible biological fluid is needed to predict if the concentration of penicillin is below tolerance in the kidney before the bovine is slaughtered. In this study, 12 steers were injected three times with the approved dose (7000 IU) of penicillin at 12-h intervals. Blood and urine samples were collected at intervals after the final dose of penicillin. At each sampling point, one kidney biopsy sample was collected by laparoscopic surgery in the live animal. Another kidney sample was collected at slaughter. Correlations between plasma and kidney concentrations and between urine and kidney concentrations were determined. These correlations predict with 95% confidence that 99% of the animals will have kidney tissue below penicillin tolerance when the plasma concentration of penicillin is below 0.4 ng/mL and/or the urine penicillin concentration is below 140 ng/mL. JF - Journal of veterinary pharmacology and therapeutics AU - Chiesa, O A AU - Von Bredow, J AU - Smith, M AU - Heller, D AU - Condon, R AU - Thomas, M H AD - Division of Residue Chemistry, Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708, USA. ochiesa@cvm.fda.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 299 EP - 306 VL - 29 IS - 4 SN - 0140-7783, 0140-7783 KW - Anti-Bacterial Agents KW - 0 KW - Penicillins KW - Index Medicus KW - Urinalysis -- veterinary KW - Animals KW - Blood Chemical Analysis -- veterinary KW - Biopsy -- veterinary KW - Abattoirs KW - Injections, Intramuscular -- veterinary KW - Male KW - Female KW - Penicillins -- pharmacology KW - Kidney -- metabolism KW - Anti-Bacterial Agents -- metabolism KW - Kidney -- pathology KW - Cattle -- urine KW - Drug Residues -- analysis KW - Penicillins -- administration & dosage KW - Cattle -- metabolism KW - Cattle -- blood KW - Penicillins -- metabolism KW - Kidney -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Anti-Bacterial Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68650896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Bovine+kidney+tissue%2Fbiological+fluid+correlation+for+penicillin.&rft.au=Chiesa%2C+O+A%3BVon+Bredow%2C+J%3BSmith%2C+M%3BHeller%2C+D%3BCondon%2C+R%3BThomas%2C+M+H&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-08-01&rft.volume=29&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=01407783&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. AN - 68644202; 16847422 AB - Animal studies suggest that lymphomagenesis can be induced by exposure to carcinogenic aromatic and heterocyclic amines found in diet, cigarette smoke and the environment, but human epidemiologic investigations of these exogenous exposures have yielded conflicting results. As part of our evaluation of the role of aromatic and heterocyclic amines, which are metabolized by N-acetyltransferase (NAT) enzymes, in the etiology of non-Hodgkin lymphoma (NHL), we examined NHL risk in relation to genetic variation in NAT1 and NAT2 and exposure to cigarette smoke and dietary heterocyclic amines and mutagens. We genotyped 10 common single nucleotide polymorphisms (SNPs) in NAT1 and NAT2 among 1136 cases and 922 controls from a population-based case-control study in four geographical areas of the USA. Relative risk of NHL for NAT1 and NAT2 genotypes, NAT2 acetylation phenotype, and exposure to cigarette smoke and dietary heterocyclic amines and mutagens was estimated using odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic regression models. We observed increased risk of NHL among individuals with the NAT1*10/*10 genotype compared with individuals with other NAT1 genotypes (OR = 1.60, 95% CI = 1.04-2.46, P = 0.03). We also observed increased NHL risk in a dose-dependent model among NAT2 intermediate- and rapid-acetylators compared with slow-acetylators, although only the trend was statistically significant (intermediate: OR = 1.18, 95% CI = 0.97-1.44, P = 0.1; rapid: OR = 1.43, 95% CI = 0.97-2.14, P = 0.07; P for linear trend = 0.03). Compared with non-smokers, NHL risk estimates for current cigarette smoking were increased only among NAT2 intermediate/rapid-acetylators (OR = 2.44, 95% CI = 1.15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL. JF - Pharmacogenetics and genomics AU - Morton, Lindsay M AU - Schenk, Maryjean AU - Hein, David W AU - Davis, Scott AU - Zahm, Shelia Hoar AU - Cozen, Wendy AU - Cerhan, James R AU - Hartge, Patricia AU - Welch, Robert AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. mortonli@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 537 EP - 545 VL - 16 IS - 8 SN - 1744-6872, 1744-6872 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Variation KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Genetic+variation+in+N-acetyltransferase+1+%28NAT1%29+and+2+%28NAT2%29+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Morton%2C+Lindsay+M%3BSchenk%2C+Maryjean%3BHein%2C+David+W%3BDavis%2C+Scott%3BZahm%2C+Shelia+Hoar%3BCozen%2C+Wendy%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2006-08-01&rft.volume=16&rft.issue=8&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenet Genomics. 2005 Aug;15(8):535-46 [16006997] Mutat Res. 2005 Jul 1;574(1-2):156-72 [15914214] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Carcinogenesis. 2006 Feb;27(2):293-7 [16113054] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] J Natl Cancer Inst. 1999 Oct 20;91(20):1751-8 [10528026] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2003 Mar;24(3):483-9 [12663508] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Jpn J Cancer Res. 1989 Dec;80(12):1176-8 [2516847] DNA Cell Biol. 1990 Apr;9(3):193-203 [2340091] Carcinogenesis. 1993 Aug;14(8):1633-8 [8353847] Arch Toxicol. 1994;68(2):129-33 [8179482] Blood. 1994 Sep 1;84(5):1361-92 [8068936] Cancer Res. 1995 Nov 15;55(22):5226-9 [7585580] JAMA. 1996 May 1;275(17):1315-21 [8614116] Carcinogenesis. 1996 Oct;17(10):2221-7 [8895492] Carcinogenesis. 1997 May;18(5):975-80 [9163683] Pharmacogenetics. 1998 Feb;8(1):55-66 [9511182] Pharmacogenetics. 1998 Feb;8(1):67-72 [9511183] Leuk Res. 1998 May;22(5):445-52 [9652731] Cancer Epidemiol Biomarkers Prev. 1999 Mar;8(3):233-9 [10090301] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Pol J Pharmacol. 2004 Jul-Aug;56(4):445-9 [15520499] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33 [15824165] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of L-carnitine pretreatment in methamphetamine and 3-nitropropionic acid-induced neurotoxicity. AN - 68150701; 17105904 AB - Adult, male Sprague-Dawley rats were injected with 3-ni-tropropionic acid (3-NPA) at 30 mg/kg or methamphetamine (METH) at 20 mg/kg alone or following pretreatment with L-cartnitine (LC) at 100 mg/kg. Rectal temperature was measured before and 4 h following treatment. Animals were sacrificed at 4 h posttreatment. Monoamine neurotransmitters, dopamine (DA) and serotonin (5-HT), and their metabolites were analyzed in the striatum using high-performance liquid chromatography method coupled with electrochemical detection (HPLC/ED). Transcripts of several genes related to DA metabolism were quantified using real time reverse transciption polymerase chain reaction (RT-PCR). Core temperature decreased significantly after 3-NPA acid and increased in METH-treated rats (P < 0.05). Temperature change at 4 h exhibited a significant LC effect for 3-NPA, preventing hypothermia (P < 0.05) and no effect for METH. Concentration of DA and 5-HT, and their metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), increased significantly in 3-NPA and decreased in METH-treated rats. An increase in DOPAC/DA turnover and serotonin observed after 3-NPA was abolished in LC-/3-NPA-treated rats. In both 3-NPA- and METH-treated rats, LC prevented an increase in DA receptor D(1) gene expression. It appears that carnitine effect preventing hypothermia after 3-NPA treatments may be related not only to its mitochondriotropic actions but also to inhibitory effect on the DA and 5-HT systems activated after the exposure to 3-NPA. The same effect observed at the transcriptional level, at least for the DA receptor D(1), may account for protection against METH toxicity. JF - Annals of the New York Academy of Sciences AU - Binienda, Zbigniew K AU - Przybyla, Beata D AU - Robinson, Bonnie L AU - Salem, Nadia AU - Virmani, Ashraf AU - Amato, Antonino AU - Ali, Syed F AD - Division of Neurotoxicology, HFT-132, FDA/NCTR, Jefferson, AR 72079-9502, USA. zbinienda@nctr.fda.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 74 EP - 83 VL - 1074 SN - 0077-8923, 0077-8923 KW - Antihypertensive Agents KW - 0 KW - Dopamine Agents KW - Nitro Compounds KW - Propionates KW - Vitamin B Complex KW - 12001-76-2 KW - Methamphetamine KW - 44RAL3456C KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Neurotoxicity Syndromes -- therapy KW - Vitamin B Complex -- pharmacology KW - Carnitine -- pharmacology KW - Dopamine Agents -- pharmacology KW - Propionates -- pharmacology KW - Methamphetamine -- pharmacology KW - Nitro Compounds -- pharmacology KW - Antihypertensive Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68150701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+zearalenone+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BAlam%2C+Hamida+Z%3BRorie%2C+James%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-09-01&rft.volume=44&rft.issue=9&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-10 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - Overview of Diabetes in Children and Adolescents. A Fact Sheet from the National Diabetes Education Program AN - 62028548; ED496109 AB - Type 1 diabetes in U.S. children and adolescents may be increasing and many more new cases of type 2 diabetes are being reported in young people. Standards of care for managing children with diabetes issued by the American Diabetes Association in January 2005 provide more guidance than previously given. To update primary care providers and their staff members on this rapidly changing area of diabetes care, the National Diabetes Education Program (NDEP) has developed this overview of the current literature. This fact sheet describes type 1 and type 2 diabetes and presents statistics, identifying children with diabetes, treatment strategies, monitoring complications and reducing CVD risk, visiting the health care team, helping children manage diabetes, prevention strategies for type 2 diabetes, and such special issues as family support, transition to independence, diabetes at school, and camps and support groups. The fact sheet also lists resources for further information about diabetes, target goals for blood glucose levels, educational materials, and support programs. [The U.S. Department of Health and Human Services' National Diabetes Education Program (NDEP) is jointly sponsored by the National Institutes of Heath (NIH) and the Centers for Disease Control and Prevention (CDC) with the support of more than 200 partner organizations.] Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 13 PB - National Diabetes Education Program. One Diabetes Way, Bethesda, MD 20814-9692. KW - ERIC, Resources in Education (RIE) KW - Prevention KW - Symptoms (Individual Disorders) KW - Therapy KW - Child Health KW - Identification KW - Children KW - Adolescents KW - Medical Services KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62028548?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Emerging Technologies and the Safety and Health of Working People AN - 58743385; 2007-20604 AB - Changes in technologies have far outpaced our knowledge about the implications of these changes for the quality of working life and for safety and health on the job. This gap in knowledge is one of the 21 priority areas for research under the National Occupational Research Agenda (NORA) -- a framework crafted by the National Institute for Occupational Safety and Health (NIOSH) and its partners to guide research into the next decade. This report was developed under NORA as a foundation for a comprehensive research agenda for investigating and reducing occupational safety and health risks as well as intervention opportunities associated with emerging technologies. Research and development needs identified in the agenda include (1) improved surveillance mechanisms to better track the emergence of technology, (2) accelerated research on safety and health implications of emerging technology, (3) increased research focus on protecting and promoting safety and health in emerging technology fields, and (4) steps to formalize and nurture emerging technology as a distinct field within occupational safety and health. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Aug 2006, 28 pp. AU - Johnson, Barry L AU - Myers, Melvin L Y1 - 2006/08// PY - 2006 DA - August 2006 EP - 28p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Science and technology policy - Technology and technology policy KW - Technological innovations KW - United States - Occupational safety and health administration KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58743385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+Barry+L%3BMyers%2C+Melvin+L&rft.aulast=Johnson&rft.aufirst=Barry&rft.date=2006-08-01&rft.volume=&rft.issue=&rft.spage=28p&rft.isbn=&rft.btitle=Emerging+Technologies+and+the+Safety+and+Health+of+Working+People&rft.title=Emerging+Technologies+and+the+Safety+and+Health+of+Working+People&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2006-136/pdfs/2006-136.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - DHHS (NIOSH) Publication No. 2006-136 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - The Novel Use of 'Asian' as an Ethnic Category in the New Zealand Health Sector AN - 57216386; 200613341 AB - 'Asian' is increasingly used as an ethnic category in the health sector in New Zealand but does not have a 'natural', fixed, uncontested meaning. Two differing constructions of 'Asian' are commonly used in New Zealand. One is racially based & includes only East & Southeast Asian peoples. It is commonly employed in popular discourse & by the media. The other construction includes peoples from East, South & Southeast Asia, but excludes peoples from the Middle East & Central Asia. This construction is recent & unique to New Zealand & is being increasingly operationalised in the health sector. This use for planning & research is problematic. For the health sector, 'Asian' does not differentiate a group of people with shared characteristics in terms of health status or needs. The diversity of the 'Asian' category, with several axes of difference, will result in an averaging of health indicators. This may result in the high health needs of groups within this category being masked or the inappropriate targeting of services. Another major concern is the general lack of acknowledgement of the contestable nature of the 'Asian' category or justification for its use. However, the 'Asian' category provides a political platform to advocate for resources & enable research into the previously ignored health status of the diverse 'Asian' population. Despite its shortcomings, usage of the category is likely to continue in the New Zealand health sector. As such, the sector needs to be aware of the limitations of the category & show greater precision in its use. 1 Table, 2 Figures, 56 References. Adapted from the source document. JF - Ethnicity & Health AU - Rasanathan, Kumanan AU - Craig, David AU - Perkins, Rod AD - Auckland Regional Public Health Service, New Zealand kumananr@yahoo.com Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 211 EP - 227 PB - Taylor & Francis, Abingdon UK VL - 11 IS - 3 SN - 1355-7858, 1355-7858 KW - Ethnicity KW - Asian KW - Indian KW - Chinese KW - New Zealand KW - Asian people KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+dosimetry+and+risk+assessment+of+nanoparticles%3A+evaluating+and+extending+current+models+in+rats+and+humans.&rft.au=Kuempel%2C+E+D%3BTran%2C+C+L%3BCastranova%2C+V%3BBailer%2C+A+J&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2006-09-01&rft.volume=18&rft.issue=10&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - ETHEFR N1 - SubjectsTermNotLitGenreText - New Zealand; Health services; Asian people; Ethnicity DO - http://dx.doi.org/10.1080/13557850600565525 ER - TY - JOUR T1 - Unraveling Cultural Threads: A Qualitative Study of Culture and Ethnic Identity among Urban Southwestern American Indian Youth Parents and Elders AN - 57056374; 200616437 AB - We utilized qualitative methods to explore ethnic & cultural identity among urban Southwestern American Indian youth, parents, & elders. Twenty-four respondents ranging in age from approximately 13 to 90 years were interviewed in focus groups divided by age. Six major themes & seventeen sub-themes related to tribal & pan-American Indian ethnic identity were identified. Two important findings emerging from our study were that common ethnic identity constructs can be validated & new identity constructs discovered through qualitative methods. These & other findings suggest the importance of qualitative methods in better understanding cultural & ethnic identity. Of particular significance was the notion that the most salient & relevant identity constructs can be learned from the voices & perspectives of ethnic identity members themselves across generations, age, tribal groups, gender, & reservation & urban residence. Tables, References. Adapted from the source document. JF - Journal of Child and Family Studies AU - House, Laura E AU - Stiffman, Arlene R AU - Brown, Eddie AD - Substance Abuse & Mental Health Services Administration, Health & Human Services, Organization & Finance Bra laura.house@samhsa.hhs.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 393 EP - 407 PB - Springer, Dordrecht The Netherlands VL - 15 IS - 4 SN - 1062-1024, 1062-1024 KW - american indian youth KW - pan-American indian identity KW - ethnic and cultural identity KW - qualitative methods KW - intergenerational contexts KW - American Indian people KW - Cultural identity KW - Ethnic identity KW - Young people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57056374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Unraveling+Cultural+Threads%3A+A+Qualitative+Study+of+Culture+and+Ethnic+Identity+among+Urban+Southwestern+American+Indian+Youth+Parents+and+Elders&rft.au=House%2C+Laura+E%3BStiffman%2C+Arlene+R%3BBrown%2C+Eddie&rft.aulast=House&rft.aufirst=Laura&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-006-9038-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JCFSES N1 - SubjectsTermNotLitGenreText - American Indian people; Ethnic identity; Young people; Cultural identity DO - http://dx.doi.org/10.1007/s10826-006-9038-9 ER - TY - JOUR T1 - A Regulatory View on Adaptive/Flexible Clinical Trial Design AN - 21139613; 11158057 AB - Recently there is growing interest in use of adaptive or flexible designs for development of pharmaceutical products. Statistical methodology has been greatly advanced in the literature. However, there are still some important issues with the methodology and application. In addition, there are many other challenges with these designs, including efficiency of these designs in the entire development program, trial conduct and logistics, the infrastructure of an adaptive trial, the regulatory evaluation of trial results and trial conduct, etc. Up till now, regulatory experience in these designs is very limited. We share some of the challenges. JF - Biometrical Journal AU - Hung, H M James AU - O'Neill, Robert T AU - Wang, Sue-Jane AU - Lawrence, John AD - Division of Biometrics I, OB/OTS/CDER/FDA, Rockville, MD, USA, hsienming.hung@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 565 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Pharmaceuticals KW - Biometrics KW - Clinical trials KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21139613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=A+Regulatory+View+on+Adaptive%2FFlexible+Clinical+Trial+Design&rft.au=Hung%2C+H+M+James%3BO%27Neill%2C+Robert+T%3BWang%2C+Sue-Jane%3BLawrence%2C+John&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Clinical trials; Statistics; Biometrics; Pharmaceuticals DO - http://dx.doi.org/10.1002/bimj.200610229 ER - TY - JOUR T1 - Some Aspects of the Application of Internal Pilot Studies AN - 21125684; 11158054 AB - This is a discussion of the paper' Sample size recalculation in internal pilot study designs' by Tim Friede and Meinhard Kieser, appearing in this special issue on adaptive designs. JF - Biometrical Journal AU - Lachenbruch, Peter A AU - Wittes, Janet AD - US Food and Drug Administration (retired), lachenbruchpa@aol.com Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 556 EP - 557 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Biometrics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21125684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Some+Aspects+of+the+Application+of+Internal+Pilot+Studies&rft.au=Lachenbruch%2C+Peter+A%3BWittes%2C+Janet&rft.aulast=Lachenbruch&rft.aufirst=Peter&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610243 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Biometrics; Statistics DO - http://dx.doi.org/10.1002/bimj.200610243 ER - TY - JOUR T1 - Rejoinder AN - 21089418; 11132871 AB - Abstract not available. JF - Biometrical Journal AU - Hung, H M James AU - O'Neill, Robert T AU - Wang, Sue-Jane AU - Lawrence, John Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 613 EP - 615 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Biometrics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21089418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Rejoinder&rft.au=Hung%2C+H+M+James%3BO%27Neill%2C+Robert+T%3BWang%2C+Sue-Jane%3BLawrence%2C+John&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610258 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Biometrics; Statistics DO - http://dx.doi.org/10.1002/bimj.200610258 ER - TY - JOUR T1 - FDA's Critical Path Initiative: A Perspective on Contributions of Biostatistics AN - 21073740; 11132863 AB - This article describes the motivation for, description of, and the objectives and plans for the FDA's initiative that was introduced in March of 2004 by way of a report titled Innovation or Stagnation? - Challenge and Opportunity on the Critical Path to New Medical Products. The FDA initiative is very much an outreach effort and a wake-up call to many constituencies to contribute and partner to improve the product development process and thereby to contribute to the success rate of new products that will benefit the public. We discuss in general terms where some of the opportunities and challenges exist for the discipline of biostatistics to make contributions to this effort over the next few years. In particular, guidance development in five areas is considered as is the need to devote new energy and efforts to quantitative risk assessment and safety evaluation, an area that has lagged the attention received in the efficacy evaluation area. JF - Biometrical Journal AU - O'Neill, R T AD - Office of Biostatistics, OTS/CDER/FDA, 10903 New Hampshire Avenue, Bldg 22, Room 6012, Silver Spring, MD 20993-0002, USA, oneill@cder.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 559 EP - 564 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Vocalization behavior KW - Motivation KW - Medical equipment KW - Energy KW - Development KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=FDA%27s+Critical+Path+Initiative%3A+A+Perspective+on+Contributions+of+Biostatistics&rft.au=O%27Neill%2C+R+T&rft.aulast=O%27Neill&rft.aufirst=R&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200510237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Development; Risk assessment; Energy; Motivation; Medical equipment; Vocalization behavior DO - http://dx.doi.org/10.1002/bimj.200510237 ER - TY - RPRT T1 - Farmer Crushed Under Falling Dump Trailer Box While Repairing Lift Cylinder AN - 20967543; 11069915 AB - A 64-year-old, part-time farmer was working in the machinery shed on his farm late in the spring of 2004. He was repairing the hydraulic cylinder lift system for the box on a tandem wheel dump trailer. He used a skid steer equipped with a pallet fork attachment to lift and hold the front of the trailer box in a raised position. This provided clearance for the farmer to access the hydraulic cylinder and lift linkage area under the middle of the dump trailer box. The man was working alone in his machine shed at the time of the incident. He had disconnected the hydraulic cylinder from the underside of the trailer box. The skid steer forks reaching in from outside the doorway held the front of the box in an elevated position similar to when a load is being dumped from the wagon box. As he leaned across the frailer frame under the box to remove the hydraulic cylinder, the trailer moved rearward. The front edge of the wagon slipped off the forks of the skid steer and the trailer box fell suddenly. The man was crushed over the lift linkage and frame by the underside of the trailer box. A few moments after the incident a relative discovered the farmer trapped under the wagon's box. Emergency crews were summoned. They used jacks and struts to secure both the wagon and the raised lift arms of the skid steer. Resuscitative efforts were not successful and the farmer was pronounced dead at the scene. RECOMMENDATIONS: Dump trailers should be equipped with rigid mechanical means to secure the trailer box in a raised position and they must be put into place without entering the area under the raised wagon box before making inspections, adjustments, or repairs under a raised box. Persons planning repairs underneath a dump trailer should securely block (chock) the rear axle wheels to prevent unexpected, inadvertent movement of the trailer. Persons inspecting or working on dump trailer lift systems should, when possible, choose to perform the task with the trailer box in its lowest position. Dump trailers should be designed to accommodate, when practicable, service and replacement of the lift system while the trailer box is in its lowest position. JF - Farmer Crushed Under Falling Dump Trailer Box While Repairing Lift Cylinder. [np]. Aug 2006. Y1 - 2006/08// PY - 2006 DA - Aug 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Hydraulics KW - Machinery KW - farms KW - inspection KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2006-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Farmer+Crushed+Under+Falling+Dump+Trailer+Box+While+Repairing+Lift+Cylinder&rft.title=Farmer+Crushed+Under+Falling+Dump+Trailer+Box+While+Repairing+Lift+Cylinder&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F sub(1) mice and F344 rats AN - 20722810; 6930423 AB - Malachite green is a triphenylmethane dye used in the fish industry as an anti-fungal agent. Leucomalachite green is formed by the metabolic reduction of malachite green and persists in the tissues of exposed fish. In this study, we examined the carcinogenicity of malachite green chloride and leucomalachite green. Female F344 rats (48 per group) were fed diets containing 0, 100, 300, or 600 ppm malachite green chloride for 104 weeks, at which time the extent of tumorigenesis was assessed. Additional groups of 48 female and 48 male F344 rats were fed diets containing 0, 91, 272, or 543 ppm leucomalachite green for 104 weeks. Groups of 48 female B6C3F sub(1) mice were fed diets containing 0, 100, 225, or 450 ppm malachite green chloride or 0, 91, 204, or 408 ppm leucomalachite green for 104 weeks. For each of the exposures, food consumption in the treatment groups was similar to the controls. Rats fed malachite green chloride or leucomalachite green had dose-dependent reductions in body weight; in mice, there were no consistent effects upon body weights with either compound. Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma. Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia. In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis. There were no treatment-related neoplasms in female B6C3F sub(1) mice fed malachite green chloride. Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group. JF - Food and Chemical Toxicology AU - Culp, Sandra J AU - Mellick, Paul W AU - Trotter, Ronald W AU - Greenlees, Kevin J AU - Kodell, Ralph L AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States, frederick.beland@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1204 EP - 1212 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 8 SN - 0278-6915, 0278-6915 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Malachite green KW - Leucomalachite green KW - Carcinogenesis KW - Testes KW - Diets KW - Leukocytes (mononuclear) KW - Mammary gland KW - Tumorigenesis KW - Thyroid KW - Chloride KW - Carcinoma KW - Leukemia KW - Food consumption KW - Body weight KW - Pituitary KW - Interstitial cells KW - Carcinogenicity KW - Adenoma KW - Hepatocellular carcinoma KW - K 03410:Animal Diseases KW - X 24135:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Single-laboratory+validation+of+a+method+for+the+determination+of+furan+in+foods+by+using+static+headspace+sampling+and+gas+chromatography%2Fmass+spectrometry.&rft.au=Nyman%2C+Patricia+J%3BMorehouse%2C+Kim+M%3BMcNeal%2C+Timothy+P%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2006-09-01&rft.volume=89&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Testes; Leukocytes (mononuclear); Mammary gland; Tumorigenesis; Thyroid; Chloride; Carcinoma; Food consumption; Leukemia; Body weight; Carcinogenicity; Interstitial cells; Pituitary; Adenoma; Hepatocellular carcinoma DO - http://dx.doi.org/10.1016/j.fct.2006.01.016 ER - TY - JOUR T1 - Adjuvant Activity of CpG Oligodeoxynucleotides AN - 20559215; 8071186 AB - Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Th1 and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5- to 500-fold. The CpG motifs present in bacterial DNA plasmids may contribute to the immunogenicity of DNA vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans and can improve vaccine-induced immune responses. JF - International Reviews of Immunology AU - Klinman, Dennis M AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 135 EP - 154 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3-4 SN - 0883-0185, 0883-0185 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphocytes B KW - Helper cells KW - Adjuvants KW - CpG islands KW - Plasmids KW - Oligonucleotides KW - Cell activation KW - Inflammation KW - Dendritic cells KW - DNA vaccines KW - Immunogenicity KW - Lymphocytes T KW - Cytokines KW - Vaccines KW - Antigen-presenting cells KW - Immune response KW - F 06905:Vaccines KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Separate+Pathways+for+O+Acetylation+of+Polymeric+and+Monomeric+Sialic+Acids+and+Identification+of+Sialyl+O-Acetyl+Esterase+in+Escherichia+coli+K1&rft.au=Steenbergen%2C+Susan+M%3BLee%2C+Young-Choon%3BVann%2C+Willie+F%3BVionnet%2C+Justine%3BWright%2C+Lori+F%3BVimr%2C+Eric+R&rft.aulast=Steenbergen&rft.aufirst=Susan&rft.date=2006-09-01&rft.volume=188&rft.issue=17&rft.spage=6195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Helper cells; CpG islands; Adjuvants; Plasmids; Oligonucleotides; Inflammation; Cell activation; Dendritic cells; DNA vaccines; Immunogenicity; Lymphocytes T; Cytokines; Immune response; Antigen-presenting cells; Vaccines DO - http://dx.doi.org/10.1080/08830180600743057 ER - TY - JOUR T1 - Human infections with Fusobacterium necrophorum AN - 20517617; 9203177 AB - Fusobacterium necrophorum is a Gram-negative anaerobic bacillus that can be a primary pathogen causing either localised abscesses and throat infections or systemic life-threatening disease. Systemic infections due to F. necrophorum are referred to as either Lemierre's disease/syndrome, post-anginal sepsis or necrobacillosis, but in the context of this mini-review, all are included under the umbrella term of 'invasive F. necrophorum disease' (IFND). Although IFND has been well documented for over a century, it is quite a rare condition and modern-day clinicians of various medical disciplines are frequently unaware of this organism and the severity of symptoms that it can cause. IFND classically occurs in previously healthy young people although the factors that trigger the invasive process are not fully understood. There are countless descriptive case histories and small series of cases of IFND disease in the literature and although commonly referred to as a forgotten' disease, in truth, it is probably best described as a repeatedly 'discovered' disease, as it may not always be included in medical curricula, and neither is it mentioned in some major medical textbooks. There is some evidence that IFND may be on the increase, particularly in the UK. The potential reasons for this are considered in this review along with an historical overview, and updates on disease incidence, patient demography, pathogenesis and laboratory diagnosis. JF - Anaerobe AU - Brazier, J S AD - Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 165 EP - 172 VL - 12 IS - 4 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Demography KW - Sepsis KW - Pharynx KW - Reviews KW - Disseminated infection KW - Fusobacterium necrophorum KW - Pathogens KW - Abscesses KW - Bacillus KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20517617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Human+infections+with+Fusobacterium+necrophorum&rft.au=Brazier%2C+J+S&rft.aulast=Brazier&rft.aufirst=J&rft.date=2006-08-01&rft.volume=12&rft.issue=4&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2005.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; Sepsis; Pharynx; Reviews; Disseminated infection; Pathogens; Abscesses; Fusobacterium necrophorum; Bacillus DO - http://dx.doi.org/10.1016/j.anaerobe.2005.11.003 ER - TY - JOUR T1 - Calpain Activation in Apoptosis of Motoneurons in Cell Culture Models of Experimental Parkinsonism AN - 20243330; 7165285 AB - Parkinson's disease (PD) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (SN). The present study briefly describes our findings to support the hypothesis that there is a possibility of degeneration of spinal cord (SC) motoneurons in course of parkinsonism. In cell culture models of experimental parkinsonism, we examined the degeneration of ventral SC motoneuron cell line (VSC4.1) following exposure to two different toxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone. Our studies suggested calpain activation in the apoptosis of VSC4.1 motoneurons due to exposure to these parkinsonian toxins. Furthermore, our study showed the toxic effects of the dopaminergic toxin methamphetamine (METH) on VSC4.1 cells. The results strongly implicated a possible role for calpain in the mechanism of motoneuron apoptosis during parkinsonian degeneration, at large. Hence, we examined the neuroprotective efficacy of calpeptin, a specific inhibitor of calpain, in cell culture model of experimental parkinsonism. JF - Annals of the New York Academy of Sciences AU - Samantaray, Supriti AU - Ray, Swapan K AU - Ali, Syed F AU - Banik, Naren L AD - Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research-FDA, Jefferson, Arkansas 72079, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 349 EP - 356 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1074 SN - 0077-8923, 0077-8923 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts; CSA Neurosciences Abstracts KW - Substantia nigra KW - Apoptosis KW - Spinal cord KW - MPTP KW - Parkinson's disease KW - Neuroprotection KW - Cell culture KW - Toxins KW - Neurodegenerative diseases KW - Motor neurons KW - Methamphetamine KW - Dopamine KW - Movement disorders KW - Rotenone KW - Neurons KW - Central nervous system diseases KW - Calpain KW - Degeneration KW - Basal ganglia KW - T 2000:Cellular Calcium KW - W 30945:Fermentation & Cell Culture KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Calpain+Activation+in+Apoptosis+of+Motoneurons+in+Cell+Culture+Models+of+Experimental+Parkinsonism&rft.au=Samantaray%2C+Supriti%3BRay%2C+Swapan+K%3BAli%2C+Syed+F%3BBanik%2C+Naren+L&rft.aulast=Samantaray&rft.aufirst=Supriti&rft.date=2006-08-01&rft.volume=1074&rft.issue=&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Substantia nigra; Apoptosis; MPTP; Spinal cord; Parkinson's disease; Cell culture; Neuroprotection; Toxins; Motor neurons; Neurodegenerative diseases; Methamphetamine; Movement disorders; Dopamine; Rotenone; Neurons; Central nervous system diseases; Calpain; Degeneration; Basal ganglia ER - TY - JOUR T1 - Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis AN - 20232871; 7131045 AB - Tamoxifen is a non-steroidal anti-estrogen used for the treatment of breast cancer and, more recently, as a chemopreventive agent in healthy women at high risk of developing breast cancer. On the other hand, tamoxifen is a potent hepatocarcinogen in rats, with both tumor-initiating and tumor-promoting properties. There is substantial evidence that hepatic tumors in rats are initiated as a result of formation of tamoxifen-DNA adducts; however, events subsequent to DNA adduct formation are not clear. Recently, it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations. In the current study, we investigated whether or not the mechanism of tamoxifen-induced hepatocarcinogenesis includes both genotoxic and epigenetic components. Female Fisher 344 rats were fed a 420 p.p.m. tamoxifen diet for 6, 12, 18 or 24 weeks. Hepatic tamoxifen-DNA adduct levels, as assessed by high-performance liquid chromatography and electrospray tandem mass spectrometry, were 580 adducts/10 super(8) nt at 6 weeks, and increased to similar to 1700 adducts/10 super(8) nt by 18 weeks. Global liver DNA hypomethylation, as determined by an HpaII-based cytosine extension assay, was increased at all time points, with the maximum increase ( similar to 200%) occurring at 6 weeks. Protein expressions of maintenance (DNMT1) DNA methyltransferase and de novo DNA methyltransferases DNMT3a and DNMT3b were decreased at all time points. Likewise, trimethylation of histone H4 lysine 20 was significantly decreased at all time points. In contrast, non-target tissues (i.e. mammary gland, pancreas and spleen) did not show any changes in global DNA methylation or DNA methyltransferase activity. These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis. JF - Carcinogenesis AU - Tryndyak, Volodymyr P AU - Muskhelishvili, Levan AU - Kovalchuk, Olga AU - Rodriguez-Juarez, Rocio AU - Montgomery, Beverly AU - Churchwell, Mona I AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research Jefferson, AR 72079, USA. Toxicologic Pathology Associates, National Center for Toxicological Research Jefferson, AR 72079, USA. Department of Biological Sciences, University of Lethbridge AB T1K 3M4, Canada. Division of Cancer Prevention, National Cancer Institute Bethesda, MD 20892, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1713 EP - 1720 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Genetics Abstracts KW - High-performance liquid chromatography KW - Risk assessment KW - Pancreas KW - Lysine KW - Carcinogens KW - Mass spectroscopy KW - Cytosine KW - Histone H4 KW - epigenetics KW - Risk factors KW - DNA methylation KW - DNA methyltransferase KW - chemopreventive agents KW - Diets KW - DNA adducts KW - Etiology KW - Data processing KW - Mammary gland KW - DNMT1 protein KW - Genotoxicity KW - Spleen KW - Tumors KW - Tamoxifen KW - Carcinogenesis KW - Liver KW - Breast cancer KW - Proteins KW - Methylation KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20232871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Effect+of+long-term+tamoxifen+exposure+on+genotoxic+and+epigenetic+changes+in+rat+liver%3A+implications+for+tamoxifen-induced+hepatocarcinogenesis&rft.au=Tryndyak%2C+Volodymyr+P%3BMuskhelishvili%2C+Levan%3BKovalchuk%2C+Olga%3BRodriguez-Juarez%2C+Rocio%3BMontgomery%2C+Beverly%3BChurchwell%2C+Mona+I%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1713&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; High-performance liquid chromatography; Pancreas; Lysine; Carcinogens; Mass spectroscopy; Cytosine; Histone H4; epigenetics; Risk factors; DNA methylation; chemopreventive agents; DNA methyltransferase; Diets; DNA adducts; Etiology; Data processing; DNMT1 protein; Mammary gland; Genotoxicity; Spleen; Tumors; Tamoxifen; Carcinogenesis; Liver; Proteins; Breast cancer; Methylation ER - TY - JOUR T1 - Occurrence of Vibrio parahaemolyticus in Fishery Products from the Southwestern Coast of Korea AN - 19987372; 7223231 AB - Fishery products were collected in seafood markets located on the southwestern coast of Korea between 2000 and 2004 and examined for the presence of Vibrio parahaemolyticus. This strain was detected in 138 of 843 samples (16.4%) that included clams, eels, crabs, octopuses, and cockles. The number of positive findings for V. parahaemolyticus among fishery products was the highest in clams at 23.6% followed by eels at 22.1%, crabs at 21.1%, octopuses at 18.0%, and cockles at 14.3%. V. parahaemolyticus was detected with overall frequencies of 15.3, 14.8, 13.8, 21.6, and 18.6% from 2000 to 2004, respectively. The monthly occurrence of the organism rapidly increased to over 20% between June and October. The monthly cases of food borne disease caused by V. parahaemolyticus in Korea over the last five years began to increase in August and reached its peak in September. However, the potential for outbreaks of food borne disease caused by V. parahaemolyticus was relatively minor between November and April. Consequently, this study shows that fishery products harvested from June to October must be handled sanitarily in Korea. JF - Food Science and Biotechnology AU - Yoon, CY AU - Kang, K J AD - Korea Food and Drug Administration, Gwangju Regional KFDA, Gwangju 500-480, Korea, kjkang@kfda.go.kr Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 578 EP - 581 VL - 15 IS - 4 SN - 1226-7708, 1226-7708 KW - Crabs KW - Crayfishes KW - Lobsters KW - Prawns KW - Shrimp KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Decapoda KW - Vibrio parahaemolyticus KW - Food KW - Seafood KW - Fishery products KW - Coasts KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19987372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Science+and+Biotechnology&rft.atitle=Occurrence+of+Vibrio+parahaemolyticus+in+Fishery+Products+from+the+Southwestern+Coast+of+Korea&rft.au=Yoon%2C+CY%3BKang%2C+K+J&rft.aulast=Yoon&rft.aufirst=CY&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Food+Science+and+Biotechnology&rft.issn=12267708&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Food; Seafood; Coasts; Fishery products; Decapoda; Vibrio parahaemolyticus ER - TY - JOUR T1 - Sequencing of the intergenic 16S-23S rRNA spacer (ITS) region of Mollicutes species and their identification using microarray-based assay and DNA sequencing AN - 19974062; 7242833 AB - We have completed sequencing the 16S-23S rRNA intergenic transcribed spacer (ITS) region of most known Mycoplasma, Acholeplasma, Ureaplasma, Mesoplasma, and Spiroplasma species. Analysis of the sequence data revealed a significant interspecies variability and low intraspecies polymorphism of the ITS region among Mollicutes. This finding enabled the application of a combined polymerase chain reaction-microarray technology for identifying Mollicutes species. The microarray included individual species-specific oligonucleotide probes for characterizing human Mollicutes species and other species known to be common cell line contaminants. Evaluation of the microarray was conducted using multiple, previously characterized, Mollicutes species. The microarray analysis of the samples used demonstrated a highly specific assay, which is capable of rapid and accurate discrimination among Mollicutes species. JF - Applied Microbiology and Biotechnology AU - Volokhov, Dmitriy V AU - George, Joseph AU - Liu, Sue X AU - Ikonomi, Pranvera AU - Anderson, Christine AU - Chizhikov, Vladimir AD - US Food and Drug Administration, HFM-470, 1401 Rockville Pike, Rockville, MD, 20852, USA, volokhov@cber.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 680 EP - 698 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 71 IS - 5 SN - 0175-7598, 0175-7598 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Mollicutes KW - Data processing KW - DNA probes KW - Acholeplasma KW - Probes KW - Spacer KW - DNA microarrays KW - Oligonucleotides KW - rRNA KW - DNA sequencing KW - Ureaplasma KW - Spiroplasma KW - Contaminants KW - Mycoplasma KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Sequencing+of+the+intergenic+16S-23S+rRNA+spacer+%28ITS%29+region+of+Mollicutes+species+and+their+identification+using+microarray-based+assay+and+DNA+sequencing&rft.au=Volokhov%2C+Dmitriy+V%3BGeorge%2C+Joseph%3BLiu%2C+Sue+X%3BIkonomi%2C+Pranvera%3BAnderson%2C+Christine%3BChizhikov%2C+Vladimir&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2006-08-01&rft.volume=71&rft.issue=5&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-005-0280-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - rRNA; DNA sequencing; Data processing; DNA probes; Probes; Spacer; Contaminants; Oligonucleotides; DNA microarrays; Mollicutes; Ureaplasma; Spiroplasma; Acholeplasma; Mycoplasma DO - http://dx.doi.org/10.1007/s00253-005-0280-7 ER - TY - JOUR T1 - Immunization to Protect the US Armed Forces: Heritage, Current Practice, and Prospects AN - 19852686; 7128186 AB - Americans serving with the US Armed Forces need protection from the dangerous infections that they can contract during training, based on occupation, during overseas deployment, or because of underlying health status. For over 230 years, the military health-care system has immunized troops to protect them personally and to help them accomplish their missions. Military researchers have invented, developed, and improved vaccines and immunization delivery methods against more than 20 diseases. This article consolidates content from several previous historical reviews, adds additional sources, and cites primary literature regarding military contributions and accomplishments. Discussion emphasizes smallpox, typhoid fever, tetanus, influenza, meningococcal disease, adenovirus, yellow fever, pneumococcal disease, and anthrax. Delivery issues include documentation, simultaneous immunization, seroscreening, safety surveillance, jet injection, and cold-chain management. Immunization policies for each major US conflict are described. Military immunization programs need to be individualized on the basis of personal contraindications and prior immunity. The proper conduct of military immunization programs respects the need for detailed education of military personnel, maximizes quality in immunization delivery, and supports quality clinical care to prevent and treat adverse events after immunization. Military immunization programs maintain the health of soldiers, marines, sailors, airmen, and coast guardsmen, the resources most critical to military success. JF - Epidemiologic Reviews AU - Grabenstein, John D AU - Pittman, Phillip R AU - Greenwood, John T AU - Engler, Renata JM AD - Office of the Surgeon General, US Army, Falls Church, VA. US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD. Allergy-Immunology Department, Vaccine Healthcare Centers Network, Walter Reed Army Medical Center, Washington, DC Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 3 EP - 26 PB - Johns Hopkins University, School of Hygiene & Public Health, Candler Bldg., Ste. 840 111 Market Place Baltimore MD 21202-6709 USA VL - 28 IS - 1 SN - 0193-936X, 0193-936X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Historical account KW - vaccines KW - meningococcal disease KW - Neisseria meningitidis KW - anthrax KW - Infection KW - Tetanus KW - immunization KW - Influenza KW - Yellow fever KW - infection KW - Anthrax KW - Military KW - Typhoid fever KW - Coasts KW - Training KW - Adenovirus KW - Immunity KW - Immunization KW - Smallpox KW - USA KW - Streptococcus pneumoniae KW - Education KW - Reviews KW - Soldiers KW - Vaccines KW - Military personnel KW - Occupational health KW - V 22350:Immunology KW - J 02350:Immunology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19852686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+Performance+of+Three+Different+Types+of+Respiratory+Protection+Devices&rft.au=Lawrence%2C+R+B%3BDuling%2C+M+G%3BCalvert%2C+CA%3BCoffey%2C+C+C&rft.aulast=Lawrence&rft.aufirst=R&rft.date=2006-09-01&rft.volume=3&rft.issue=9&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600829211 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Historical account; meningococcal disease; Immunity; Tetanus; Infection; Immunization; Smallpox; Influenza; Yellow fever; Reviews; Soldiers; Anthrax; Vaccines; Typhoid fever; Military personnel; Coasts; immunization; vaccines; Education; Training; infection; anthrax; Military; Occupational health; Streptococcus pneumoniae; Adenovirus; Neisseria meningitidis; USA ER - TY - JOUR T1 - Intratumoral Therapy with IL13-PE38 Results in Effective CTL-Mediated Suppression of IL-13R alpha 2-Expressing Contralateral Tumors AN - 19850245; 7131201 AB - PURPOSE: IL13-PE38, a targeted cytotoxin comprised of interleukin 13 (IL-13) and a mutated form of Pseudomonas exotoxin, induces specific killing of tumor cells expressing abundant levels of the IL-13R alpha 2 chain. We hypothesized that tumor cells killed by the cytotoxin may release antigens and/or apoptotic bodies when cells are dying, which then induce adoptive immunity, and that the PE38 portion of IL13-PE38 may act as a stimulant for the induction of a CTL response. Experimental Design: To test this hypothesis, we established D5 melanoma tumors with or without expression of the IL-13R alpha 2 chain in both flanks of C57BL/6 mice, and then IL13-PE38 was injected in the right flank tumors only. RESULTS: and Conclusions: When animals with IL-13R alpha 2-expressing D5 tumor (right) were injected with IL13-PE38, right flank tumors expressing the IL-13R alpha 2 chain not only showed dramatic regression but contralateral tumors (left flank) also showed tumor regression. Cell depletion experiments in tumor-bearing animals indicated that both CD8 super(+) and CD4 super(+) T cells contribute to the regression of contralateral tumors through CTL activation in the periphery and cellular infiltration into tumors. In addition, intratumoral treatment into s.c. tumors of mice bearing metastatic lung tumors with IL13-PE38 showed not only the reduction of treated s.c. tumor but also the reduction of lung metastasis. Thus, IL13-PE38 mediates an antitumor effect not only directly but also indirectly by inducing a host CD8 super(+) T cell immune response. Accordingly, targeted cytotoxins may be used to treat local disease even if they cannot be administered systemically, and yet may still induce a reasonable systemic antitumor response. JF - Clinical Cancer Research AU - Kawakami, Koji AU - Terabe, Masaki AU - Kioi, Mitomu AU - Berzofsky, Jay A AU - Puri, Raj K AD - Authors' Affiliations: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville Pike, Rockville Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 4678 EP - 4686 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 15 SN - 1078-0432, 1078-0432 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Cytotoxins KW - Interleukin 1 KW - Pseudomonas KW - Stimulants KW - CD8 antigen KW - Tumors KW - Immunity KW - Tumor cells KW - Exotoxins KW - Cell activation KW - Melanoma KW - Metastases KW - CD4 antigen KW - Cytotoxicity KW - Interleukin 13 KW - Lung KW - Lymphocytes T KW - Antitumor activity KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Intratumoral+Therapy+with+IL13-PE38+Results+in+Effective+CTL-Mediated+Suppression+of+IL-13R+alpha+2-Expressing+Contralateral+Tumors&rft.au=Kawakami%2C+Koji%3BTerabe%2C+Masaki%3BKioi%2C+Mitomu%3BBerzofsky%2C+Jay+A%3BPuri%2C+Raj+K&rft.aulast=Kawakami&rft.aufirst=Koji&rft.date=2006-08-01&rft.volume=12&rft.issue=15&rft.spage=4678&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Cytotoxins; Interleukin 1; Stimulants; Immunity; Tumors; CD8 antigen; Tumor cells; Exotoxins; Melanoma; Cell activation; Metastases; Interleukin 13; Cytotoxicity; CD4 antigen; Lung; Lymphocytes T; Antitumor activity; Pseudomonas ER - TY - JOUR T1 - Optimization of extrusion conditions for elimination of mesophilic bacteria during thermal processing of animal feed mash AN - 19839251; 6965338 AB - Salmonella and other pathogenic organisms that infect poultry and other livestock can originate from feed and environmental sources. Thus, measures are taken to control Salmonella infection in animals to improve food safety and reduce production losses. The current study was designed to investigate and optimize extrusion conditions for reducing bacterial counts in a surrogate feed matrix. A single-screw extruder was used to process feed artificially inoculated with Bacillus stearothermophilus 12980 (ATCC, Reston, Virginia). Preliminary experiments demonstrated that Salmonella typhimurium (S. typhimurium NAL super(r)) was eliminated from feed under conditions of moderate extrusion stringency (285 g moisture/kg mash feed, 83 degree C extruder barrel exit temperature, 7 s retention time in the extruder barrel) and, therefore, a more thermotolerant organism was required to conduct the study. Spores of B. stearothermophilus 12980 inoculated into a surrogate feed matrix consisting of 600 g maize meal/kg, 300 g soya bean meal/kg and 100 g animal protein blend/kg, respectively, was used to investigate the effect of three extrusion variables on microbial killing. The three variables were extruder barrel exit temperature (T), mash feed moisture content (M sub(c)), and mean retention time of feed in the extruder barrel (R sub(t)). A rotatable central composite statistical design was used with three independent variables and five levels each. The quadratic response surface model fit to spore count data was used to predict extrusion conditions that maximized bacterial killing. The response surface indicated a stationary point within the design region that was a saddle. An estimated ridge of maximum killing indicated that a maximum reduction of 1.03 log cycles would occur under the following extruder settings: T = 110 degree C, M sub(c) = 245 g/kg and R sub(t) = 11 s. Because the moderate stringency condition (T = 83 degree C, M sub(c) = 285 g/kg and R sub(t) = 7 s) completely eliminated detectable S. typhimurium in the test feed matrix, it would appear that all S. typhimurium cells and all mesophilic organisms of similar thermal tolerance would be eliminated at most extruder conditions within the central composite design region. JF - Animal Feed Science and Technology AU - Okelo, PO AU - Wagner, D D AU - Carr, LE AU - Wheaton, F W AU - Douglass, L W AU - Joseph, S W AD - Center for Veterinary Medicine, US Food and Drug Administration, Rockville, MD 20855, United States, Phares.Okelo@fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 116 EP - 137 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 129 IS - 1-2 SN - 0377-8401, 0377-8401 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella typhimurium KW - Bacillus stearothermophilus KW - Bacteria KW - Feeds KW - Extrusion KW - Mash KW - Thermal processing KW - Temperature effects KW - Mesophilic bacteria KW - Poultry KW - Statistics KW - Data processing KW - Food KW - Temperature requirements KW - Infection KW - Beans KW - Livestock KW - Zea mays KW - Food sources KW - Spores KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Animal+Feed+Science+and+Technology&rft.atitle=Optimization+of+extrusion+conditions+for+elimination+of+mesophilic+bacteria+during+thermal+processing+of+animal+feed+mash&rft.au=Okelo%2C+PO%3BWagner%2C+D+D%3BCarr%2C+LE%3BWheaton%2C+F+W%3BDouglass%2C+L+W%3BJoseph%2C+S+W&rft.aulast=Okelo&rft.aufirst=PO&rft.date=2006-08-01&rft.volume=129&rft.issue=1-2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Animal+Feed+Science+and+Technology&rft.issn=03778401&rft_id=info:doi/10.1016%2Fj.anifeedsci.2005.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Mesophilic bacteria; Poultry; Data processing; Statistics; Food; Food sources; Temperature requirements; Infection; Spores; Beans; Livestock; Bacillus stearothermophilus; Zea mays; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.anifeedsci.2005.12.011 ER - TY - JOUR T1 - Oligonucleotide-based Analysis of Differentially Expressed Genes in Hippocampus of Transgenic Mice Expressing NSE-controlled APPsw AN - 19821696; 7138225 AB - The complexity of Alzheimer's disease (AD) has made it difficult to examine its underlying mechanisms. A gene microarray offers a solution to the complexity through parallel analysis of most of the genes expressed in the hippocampal tissues from AD-transgenic and age-matched control littermates. This study examined the potential effect of APPsw over-expression on the modulation of genes for AD. To accomplish this, an oligonucleotide array was used with the large-scale screening of the hippocampus mRNA from 12-month-old APPsw-transgenic and control mice. There was a total of 116 differentially expressed genes, 59 up-regulated and 57 down-regulated, in the hippocampal region of the transgenic mice compared with the control mice. Initially, two of each of the down-regulated (Xlr3b and Mup3) and up-regulated genes (Serpina9 and Ccr6) were chosen for further investigation if the magnitude of change in these genes on the oligonucleotide array would correspond to those in the RT-PCR analysis from APPsw-transgenic mice. We also found that the changes in the differentially expressed genes are reliable. Thus, these genes might associate with AD neuropathology in neurodegenerative process of AD, although relevance of long lists altered genes should be evaluated in a future study. JF - Neurochemical Research AU - Jee, Seung W AU - Cho, Jung S AU - Kim, Chuel K AU - Hwang, Dae Y AU - Shim, Sun B AU - Lee, Su H AU - Sin, Ji S AU - Park, Jin H AU - Kim, Yang S AU - Choi, Soo Y AU - Kim, Yong K AD - National Institute of Toxicological Research, Korea FDA, Seoul, 122-704, Republic of Korea, kimyongkyu@hanmail.net Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1035 EP - 1044 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 31 IS - 8 SN - 0364-3190, 0364-3190 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Neuromodulation KW - Hippocampus KW - Overexpression KW - CCR6 protein KW - Alzheimer's disease KW - Polymerase chain reaction KW - Transgenic mice KW - DNA microarrays KW - Neuropathology KW - mRNA KW - W 30925:Genetic Engineering KW - N3 11008:Neurochemistry KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19821696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Oligonucleotide-based+Analysis+of+Differentially+Expressed+Genes+in+Hippocampus+of+Transgenic+Mice+Expressing+NSE-controlled+APPsw&rft.au=Jee%2C+Seung+W%3BCho%2C+Jung+S%3BKim%2C+Chuel+K%3BHwang%2C+Dae+Y%3BShim%2C+Sun+B%3BLee%2C+Su+H%3BSin%2C+Ji+S%3BPark%2C+Jin+H%3BKim%2C+Yang+S%3BChoi%2C+Soo+Y%3BKim%2C+Yong+K&rft.aulast=Jee&rft.aufirst=Seung&rft.date=2006-08-01&rft.volume=31&rft.issue=8&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-006-9117-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Neuromodulation; Hippocampus; CCR6 protein; Overexpression; Alzheimer's disease; Polymerase chain reaction; Transgenic mice; DNA microarrays; Neuropathology; mRNA DO - http://dx.doi.org/10.1007/s11064-006-9117-8 ER - TY - JOUR T1 - Subunit Recombinant Vaccine Protects against Monkeypox AN - 19773087; 7132018 AB - The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in combination with the equivalent recombinant proteins produced in Escherichia coli. Animals that received only DNA failed to produce high titer Abs, developed innumerable skin lesions after challenge, and died in a manner similar to placebo controls. By contrast, the animals vaccinated with proteins developed moderate to severe disease (20-155 skin lesions) but survived. Importantly, those immunized with DNA and boosted with proteins had mild disease with 15 or fewer lesions that resolved within days. DNA/protein immunization elicited Th responses and binding Ab titers to all four proteins that correlated negatively with the total lesion number. The sera of the immunized macaques recognized a limited number of linear B cell epitopes that are highly conserved among orthopoxviruses. Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox. JF - Journal of Immunology AU - Heraud, Jean-Michel AU - Edghill-Smith, Yvette AU - Ayala, Victor AU - Kalisz, Irene AU - Parrino, Janie AU - Kalyanaraman, Vaniambadi S AU - Manischewitz, Jody AU - King, Lisa R AU - Hryniewicz, Anna AU - Trindade, Christopher J AU - Hassett, Meredith AU - Tsai, Wen-Po AU - Venzon, David AU - Nalca, Aysegul AU - Vaccari, Monica AU - Silvera, Peter AU - Bray, Mike AU - Graham, Barney S AU - Golding, Hana AU - Hooper, Jay W AU - Franchini, Genoveffa AD - Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892. Southern Research Institute, Frederick, MD 21701. Advanced BioScience Laboratories, Kensington, MD 20895. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of General and Experimental Pathology, Medical University of Bialystok, Bialystok, Poland. Biostatistics and Data Management Section, National Cancer Institute, Bethesda, MD 20892. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702. Biodefense Clinical Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2552 EP - 2564 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 4 SN - 0022-1767, 0022-1767 KW - Rhesus macaque KW - Rhesus monkey KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Monkeypox KW - Lymphocytes B KW - Antibody response KW - Plasmids KW - Immunization KW - Smallpox KW - Antibodies KW - Vaccinia virus KW - Skin diseases KW - Escherichia coli KW - DNA KW - Macaca mulatta KW - Vaccines KW - Epitopes KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Subunit+Recombinant+Vaccine+Protects+against+Monkeypox&rft.au=Heraud%2C+Jean-Michel%3BEdghill-Smith%2C+Yvette%3BAyala%2C+Victor%3BKalisz%2C+Irene%3BParrino%2C+Janie%3BKalyanaraman%2C+Vaniambadi+S%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BHryniewicz%2C+Anna%3BTrindade%2C+Christopher+J%3BHassett%2C+Meredith%3BTsai%2C+Wen-Po%3BVenzon%2C+David%3BNalca%2C+Aysegul%3BVaccari%2C+Monica%3BSilvera%2C+Peter%3BBray%2C+Mike%3BGraham%2C+Barney+S%3BGolding%2C+Hana%3BHooper%2C+Jay+W%3BFranchini%2C+Genoveffa&rft.aulast=Heraud&rft.aufirst=Jean-Michel&rft.date=2006-08-01&rft.volume=177&rft.issue=4&rft.spage=2552&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smallpox; Antibodies; Monkeypox; Skin diseases; Lymphocytes B; DNA; Antibody response; Vaccines; Plasmids; Immunization; Epitopes; Vaccinia virus; Escherichia coli; Macaca mulatta ER - TY - JOUR T1 - Widening socioeconomic inequalities in US life expectancy, 1980-2000 AN - 19631550; 7361695 AB - Background This study examines changes in the extent of inequalities in life expectancy at birth and other ages in the United States between 1980 and 2000 by gender and socioeconomic deprivation levels. Methods A factor-based deprivation index consisting of 11 education, occupation, wealth, income distribution, unemployment, poverty, and housing quality indicators was used to define deprivation deciles, which were then linked to the US mortality data at the county-level. Life expectancy estimates were developed by age, gender, and deprivation levels for three 3 year time periods: 1980-82, 1989-91, and 1998-2000. Inequalities in life expectancy were measured by the absolute difference between the least-deprived group and each of the other deprivation deciles. Slope indices of inequality for each gender and time period were calculated by regressing life expectancy estimates on deprivation levels using weighted least squares models. Results Those in less-deprived groups experienced a longer life expectancy at each age than their counterparts in more-deprived groups. In 1980-82, the overall life expectancy at birth was 2.8 years longer for the least-deprived group than for the most-deprived group (75.8 vs 73.0 years). By 1998-2000, the absolute difference in life expectancy at birth had increased to 4.5 years (79.2 vs 74.7 years). The inequality indices also showed a substantial widening of the deprivation gradient in life expectancy during the study period for both males and females. Conclusions Between 1980 and 2000, those in higher socioeconomic groups experienced larger gains in life expectancy than those in more-deprived groups, contributing to the widening gap. JF - International Journal of Epidemiology AU - Singh, G K AU - Siahpush, M AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA, gsingh@hrsa.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 969 EP - 979 VL - 35 IS - 4 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - Mortality KW - USA KW - Education KW - unemployment KW - Housing KW - poverty KW - income KW - Gender KW - Socioeconomics KW - life span KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19631550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Widening+socioeconomic+inequalities+in+US+life+expectancy%2C+1980-2000&rft.au=Singh%2C+G+K%3BSiahpush%2C+M&rft.aulast=Singh&rft.aufirst=G&rft.date=2006-08-01&rft.volume=35&rft.issue=4&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdyl083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Education; unemployment; Housing; poverty; income; Gender; Socioeconomics; life span; USA DO - http://dx.doi.org/10.1093/ije/dyl083 ER - TY - JOUR T1 - Detection of Cashew Nut DNA in Spiked Baked Goods Using a Real-Time Polymerase Chain Reaction Method AN - 19500862; 7195763 AB - The detection of potentially allergenic foods, such as tree nuts, in food products is a major concern for the food processing industry. A real-time polymerase chain reaction (PCR) method was designed to determine the presence of cashew DNA in food products. The PCR amplifies a 67 bp fragment of the cashew 2S albumin gene, which is detected with a cashew-specific, dual-labeled TaqMan probe. This reaction will not amplify DNA derived from other tree nut species, such as almond, Brazil nut, hazelnut, and walnut, as well as 4 varieties of peanut. This assay was sensitive enough to detect 5 pg purified cashew DNA as well as cashew DNA in a spiked chocolate cookie sample containing 0.01% (100 mg/kg) cashew. JF - Journal of AOAC International AU - Brzezinski, J L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Dr, Cincinnati, OH 45237, USA, jennifer.brzezinski@fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1035 EP - 1038 VL - 89 IS - 4 SN - 1060-3271, 1060-3271 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Food processing KW - Arachis hypogaea KW - Prunus dulcis KW - Trees KW - Food KW - Probes KW - Nuts KW - Chocolate KW - Juglans KW - Anacardium KW - Prunus KW - Albumin KW - Polymerase chain reaction KW - Corylus KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+Cashew+Nut+DNA+in+Spiked+Baked+Goods+Using+a+Real-Time+Polymerase+Chain+Reaction+Method&rft.au=Brzezinski%2C+J+L&rft.aulast=Brzezinski&rft.aufirst=J&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Food processing; Trees; Food; Albumin; Probes; Chocolate; Nuts; Polymerase chain reaction; Arachis hypogaea; Prunus dulcis; Juglans; Anacardium; Corylus; Prunus ER - TY - JOUR T1 - Studies of the Effects of Neonatal Exposure to Genistein on the Developing Female Reproductive System AN - 19499246; 7195765 AB - Studies have shown that developmental exposure to genistein alters murine reproductive differentiation, resulting in abnormal ovarian development (multioocyte follicles) and uterine neoplasia later in life. Further, reproductive function was altered. Prolonged estrous cyclicity was observed following neonatal genistein treatment (0.5-50 mg/kg) on Days 1-5 with doseand age-related increase in severity. Fertility, determined at 2, 4, and 6 months, showed decreased numbers of genistein-treated females (0.5 or 5 mg/kg) delivering live pups and reduced numbers of pups. At 6 months, 60% of 0.5 mg/kg and 40% of 5 mg/kg groups delivered live pups compared to 100% of controls. At 2 months, half the mice treated with 25 mg/kg of genistein and none treated with 50 mg/kg delivered live pups, although half of the latter group showed signs of pregnancy with few small implantation sites. Ovarian function was disrupted in the low genistein-dosed mice with increased numbers of corpora lutea (CLs) compared to controls and increased ovulated oocytes following exogenous gonadotropins treatment. In contrast, mice treated with high genistein doses had decreased numbers of CLs; ovulation could be restored with exogenous gonadotropins. Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function. JF - Journal of AOAC International AU - Jefferson, W N AU - Padilla-Banks, E AU - Newbold, R R AD - National Institute of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA, jeffers1@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1189 EP - 1196 VL - 89 IS - 4 SN - 1060-3271, 1060-3271 KW - Toxicology Abstracts KW - Uterus KW - Fertility KW - Follicles KW - Gonadotropins KW - Reproductive system KW - Neoplasia KW - Pregnancy KW - Differentiation KW - Ovulation KW - Oocytes KW - Neonates KW - Estrus cycle KW - Genistein KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19499246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Studies+of+the+Effects+of+Neonatal+Exposure+to+Genistein+on+the+Developing+Female+Reproductive+System&rft.au=Jefferson%2C+W+N%3BPadilla-Banks%2C+E%3BNewbold%2C+R+R&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2006-08-01&rft.volume=89&rft.issue=4&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fertility; Uterus; Follicles; Gonadotropins; Neoplasia; Reproductive system; Pregnancy; Differentiation; Ovulation; Oocytes; Neonates; Genistein; Estrus cycle ER - TY - JOUR T1 - Methamphetamine Induces Autophagy and Apoptosis in a Mesencephalic Dopaminergic Neuronal Culture Model: Role of Cathepsin-D in Methamphetamine-Induced Apoptotic Cell Death AN - 19468642; 7165272 AB - Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-induced oxidative damage in dopaminergic neuronal systems remains unclear. The goals of the present article were twofold: (a) to develop an in vitro dopaminergic cell culture model to study cellular and molecular mechanisms underlying METH-ind-uced autophagy and apoptosis, and (b) to determine whether lysosomal protease cathepsin-D activation, resulting from the loss of lysosomal membrane integrity, contributes to METH-induced apoptosis. To accomplish these goals, we characterized morphological and biochemical changes in an immortalized mesencephalic dopaminergic neuronal cell line (N27 cells) following treatment with METH. Exposure of METH (2 mM) to N27 cells resulted in the appearance of cytoplasmic vacuolar structures reminiscent of autophagic vacuoles within 3 h. In order to ascertain the identity of the vacuolar structures that are formed following METH exposure, immunohistochemical staining for markers of autophagy were performed. LAMP 2, a classical marker of autophagolysosomes, revealed an extensive punctuate pattern of distribution on the vacuolar membrane surface, with exclusive localization in the cytoplasm. Additionally, using DNA fragmentation analysis we showed a dose-dependent increase in fragmented DNA in METH treated N27 cells. Since METH-induced autophagy preceded DNA fragmentation, we tested whether dysfunction of the autophagolysosomal system contributes to nuclear damage. Immunofluorescence studies with cathepsin-D demonstrated a granular pattern of staining in untreated cells, whereas an increased cathepsin- D immunoreactivity with a globular pattern of staining was observed in METH-treated cells. Nevertheless, blockade of cathepsin-D activation by pepstatin-A, cathepsin-D inhibitor, failed to alter METH-induced DNA fragmentation. Collectively, these results demonstrate that N27 dopaminergic neuronal cell model may serve as an excellent in vitro model to study the mechanisms of METH-induced autophagy and apoptosis. Furthermore, it is less likely that cathepsin-D may serve as a trigger for the induction of apoptosis subsequent to exposure of N27 dopaminergic neuronal cells to METH. JF - Annals of the New York Academy of Sciences AU - Kanthasamy, Arthi AU - Anantharam, V AU - Ali, Syed F AU - Kanthasamy, A G AD - Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011-1250, USA Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, Arkansas 72079, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 234 EP - 244 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1074 SN - 0077-8923, 0077-8923 KW - Sustainability Science Abstracts; CSA Neurosciences Abstracts KW - Phylogeny KW - Mortality KW - Molecular modelling KW - Membranes KW - Apoptosis KW - Biochemistry KW - Stress KW - Cell culture KW - Immunofluorescence KW - DNA fragmentation KW - Methamphetamine KW - Dopamine KW - Oxidative stress KW - Cytoplasm KW - Neurotoxicity KW - Immunoreactivity KW - Vacuoles KW - DNA KW - Proteins KW - Proteinase KW - Organelles KW - M3 1010:Issues in Sustainable Development KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Methamphetamine+Induces+Autophagy+and+Apoptosis+in+a+Mesencephalic+Dopaminergic+Neuronal+Culture+Model%3A+Role+of+Cathepsin-D+in+Methamphetamine-Induced+Apoptotic+Cell+Death&rft.au=Kanthasamy%2C+Arthi%3BAnantharam%2C+V%3BAli%2C+Syed+F%3BKanthasamy%2C+A+G&rft.aulast=Kanthasamy&rft.aufirst=Arthi&rft.date=2006-08-01&rft.volume=1074&rft.issue=&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Molecular modelling; Apoptosis; Cell culture; Immunofluorescence; DNA fragmentation; Methamphetamine; Dopamine; Oxidative stress; Cytoplasm; Vacuoles; Immunoreactivity; Neurotoxicity; Proteinase; Organelles; Mortality; Membranes; Biochemistry; DNA; Proteins; Stress ER - TY - JOUR T1 - Current and future issues in the manufacturing and development of monoclonal antibodies AN - 19454168; 7040814 AB - Despite a slow beginning, monoclonal antibodies have had many successes over the past decade. It is important that these successes continue, bringing more products for more indications to market. Although manufacturing is not the most common cause of product failure, product quality issues can delay antibody development. Manufacturing has depended on the triad of process validation, process control and product testing. Applying product knowledge proactively to manufacturing (quality by design) may allow greater flexibility and maintain or improve product quality. An integrated approach to biological characterization is an important aspect of product knowledge. Greater product knowledge also facilitates development in other disciplines. Independent of manufacturing strategy, there are a number of regulatory hurdles in initial and ongoing antibody development. These are described to help prevent unnecessary delays. JF - Advanced Drug Delivery Reviews AU - Kozlowski, Steven AU - Swann, Patrick AD - Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, steven.kozlowski@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 707 EP - 722 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 58 IS - 5-6 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Monoclonal antibodies KW - Reviews KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Current+and+future+issues+in+the+manufacturing+and+development+of+monoclonal+antibodies&rft.au=Kozlowski%2C+Steven%3BSwann%2C+Patrick&rft.aulast=Kozlowski&rft.aufirst=Steven&rft.date=2006-08-01&rft.volume=58&rft.issue=5-6&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2006.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Reviews; Drug delivery DO - http://dx.doi.org/10.1016/j.addr.2006.05.002 ER - TY - JOUR T1 - A Nationwide Population-Based Study Identifying Health Disparities Between American Indians/Alaska Natives and the General Populations Living in Select Urban Counties AN - 19367981; 7127222 AB - OBJECTIVES: Despite their increasing numbers, little is known about the health of American Indians/Alaska Natives living in urban areas. We examined the health status of American Indian/Alaska Native populations served by 34 federally funded urban Indian health organizations. METHODS: We analyzed US census data and vital statistics data for the period 1990 to 2000. RESULTS: Disparities were revealed in socioeconomic, maternal and child health, and mortality indicators between American Indians/Alaska Natives and the general populations in urban Indian health organization service areas and nationwide. American Indians/Alaska Natives were approximately twice as likely as these general populations to be poor, to be unemployed, and to not have a college degree. Similar differences were observed in births among mothers who received late or no prenatal care or consumed alcohol and in mortality attributed to sudden infant death syndrome, chronic liver disease, and alcohol consumption. CONCLUSIONS: We found health disparities between American Indians/Alaska Natives and the general populations living in selected urban areas and nationwide. Such disparities can be addressed through improvements in health care access, high-quality data collection, and policy initiatives designed to provide sufficient resources and a more unified vision of the health of urban American Indians/Alaska Natives. JF - American Journal of Public Health AU - Castor, Mei L AU - Smyser, Michael S AU - Taualii, Maile M AU - Park, Alice N AU - Lawson, Shelley A AU - Forquera, Ralph A AD - Mei L. Castor, Maile M. Taualii, Alice N. Park, and Ralph A. Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, Wash. Mei L. Castor is also with the Indian Health Service, Albuquerque, NM. Michael S. Smyser and Shelly A. Lawson are with Public Health-Seattle and King County, Seattle Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1478 EP - 1484 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 8 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - Alcohol KW - Mortality KW - Data collection KW - Health care KW - Liver KW - Socioeconomics KW - INE, USA, Alaska KW - vital statistics KW - Urban areas KW - Public health KW - sudden infant death syndrome KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=A+Nationwide+Population-Based+Study+Identifying+Health+Disparities+Between+American+Indians%2FAlaska+Natives+and+the+General+Populations+Living+in+Select+Urban+Counties&rft.au=Castor%2C+Mei+L%3BSmyser%2C+Michael+S%3BTaualii%2C+Maile+M%3BPark%2C+Alice+N%3BLawson%2C+Shelley+A%3BForquera%2C+Ralph+A&rft.aulast=Castor&rft.aufirst=Mei&rft.date=2006-08-01&rft.volume=96&rft.issue=8&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Alcohol; Data collection; Health care; Liver; Socioeconomics; vital statistics; sudden infant death syndrome; Public health; Urban areas; INE, USA, Alaska ER - TY - JOUR T1 - CXCL16 Influences the Nature and Specificity of CpG-Induced Immune Activation AN - 19367723; 7129082 AB - Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. This work establishes that CXCL16, a membrane-bound scavenger receptor, influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. This is the first example of a surface receptor modifying the cellular specificity and nature of the immune response mediated by an intracellular TLR. JF - Journal of Immunology AU - Gursel, Mayda AU - Gursel, Ihsan AU - Mostowski, Howard S AU - Klinman, Dennis M AD - Section of Retroviral Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1575 EP - 1580 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 3 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chemokines KW - Lymphocytes B KW - Helper cells KW - Immune system KW - CpG islands KW - Oligonucleotides KW - Inflammation KW - Dendritic cells KW - Lymphocytes T KW - Cytokines KW - Immune response KW - CXCL16 protein KW - scavenger receptors KW - F 06960:Molecular Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CXCL16+Influences+the+Nature+and+Specificity+of+CpG-Induced+Immune+Activation&rft.au=Gursel%2C+Mayda%3BGursel%2C+Ihsan%3BMostowski%2C+Howard+S%3BKlinman%2C+Dennis+M&rft.aulast=Gursel&rft.aufirst=Mayda&rft.date=2006-08-01&rft.volume=177&rft.issue=3&rft.spage=1575&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemokines; Lymphocytes B; Immune system; Helper cells; CpG islands; Oligonucleotides; Inflammation; Dendritic cells; Lymphocytes T; Cytokines; CXCL16 protein; Immune response; scavenger receptors ER - TY - JOUR T1 - A novel ceftazidime-hydrolysing extended-spectrum {szligbeta}-lactamase, CTX-M-54, with a single amino acid substitution at position 167 in the omega loop AN - 19366310; 7128463 AB - OBJECTIVES: To characterize a novel ceftazidime-hydrolysing CTX-M mutant, designated CTX-M-54, produced by Klebsiella pneumoniae clinical isolate BDK0419 and to investigate its genetic environment. METHODS: Antimicrobial susceptibilities were determined by disc diffusion and agar dilution methods, and the double-disc synergy test was carried out. Detection of genes encoding class A {szligbeta}-lactamases was performed by PCR amplification, and the genetic organization of the bla sub(CTX-M-54) gene was investigated by PCR and sequencing of the regions surrounding this gene. Kinetic parameters were determined from purified CTX-M-54. RESULTS: The strain BDK0419 contained a transferable plasmid with a molecular size of similar to 21 kbp that carries both bla sub(SHV-2a) and bla sub(CTX-M-54) {szligbeta}-lactamase genes, along with two other plasmids. The bla sub(CTX-M-54) gene was flanked upstream by an ISEcp1 insertion sequence and downstream by an IS903-like element. CTX-M-54 had a P167Q substitution within the omega loop region of class A {szligbeta}-lactamases compared with the sequence of CTX-M-3. The MIC of ceftazidime for K. pneumoniae BDK0419 was 16-fold higher than that of cefotaxime; however, the kinetic parameter of CTX-M-54 against ceftazidime revealed a low catalytic efficiency. CONCLUSIONS: This work shows once again that novel CTX-M enzymes with an expanded activity towards ceftazidime through a single amino acid substitution can be identified from clinical isolates. Thus, detection of CTX-M enzymes can no longer be based solely on the resistance phenotypes of clinical isolates towards ceftazidime and cefotaxime. JF - Journal of Antimicrobial Chemotherapy AU - Bae, Il Kwon AU - Lee, Byung Ho AU - Hwang, Hyun Yong AU - Jeong, Seok Hoon AU - Hong, Seong Geun AU - Chang, Chulhun L AU - Kwak, Hyo-Sun AU - Kim, Hyoung Jin AU - Youn, Hasik AD - Department of Laboratory Medicine, Kosin University College of Medicine 602-030, 34 Amnam-Dong, Suh-Gu, Busan, Korea. Department of Laboratory Medicine, Pochon CHA University College of Medicine 463-712, 351 Yatap-Dong, Bundang-Gu, Sungnam, Korea. Department of Laboratory Medicine, Pusan National University School of Medicine 602-739, Suh-Gu, Ami-Dong 1-10, Busan, Korea. Center for Food Safety Evaluation, Korea Food and Drug Administration 122-704, 231 Jinheung-Ro, Eunpyung-Gu, Seoul, Korea. R&D Park, LG Life Sciences Ltd 305-380, 104-1 Moonji-Dong, Yuseong-Gu, Daejeon, Korea Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 315 EP - 319 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 2 SN - 0305-7453, 0305-7453 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Agar KW - Cefotaxime KW - Amino acid substitution KW - Enzymes KW - Plasmids KW - Insertion sequences KW - Minimum inhibitory concentration KW - Ceftazidime KW - Kinetics KW - Polymerase chain reaction KW - Diffusion KW - Klebsiella pneumoniae KW - W 30915:Pharmaceuticals & Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=A+novel+ceftazidime-hydrolysing+extended-spectrum+%7Bszligbeta%7D-lactamase%2C+CTX-M-54%2C+with+a+single+amino+acid+substitution+at+position+167+in+the+omega+loop&rft.au=Bae%2C+Il+Kwon%3BLee%2C+Byung+Ho%3BHwang%2C+Hyun+Yong%3BJeong%2C+Seok+Hoon%3BHong%2C+Seong+Geun%3BChang%2C+Chulhun+L%3BKwak%2C+Hyo-Sun%3BKim%2C+Hyoung+Jin%3BYoun%2C+Hasik&rft.aulast=Bae&rft.aufirst=Il&rft.date=2006-08-01&rft.volume=58&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Ceftazidime; Agar; Amino acid substitution; Cefotaxime; Kinetics; Polymerase chain reaction; Enzymes; Diffusion; Insertion sequences; Plasmids; Minimum inhibitory concentration; Klebsiella pneumoniae ER - TY - JOUR T1 - Hemoglobin adducts in workers exposed to benzidine and azo dyes AN - 19364928; 7131032 AB - Benzidine (Bz) is a known human carcinogen. Several azo dyes have been synthesized with Bz. Bz can be metabolically released from azo dyes. In a group of Indian workers producing Bz and azo dyes the presence of hemoglobin (Hb) adducts was investigated. The following Hb adducts were identified and quantified by GC-MS: Bz, N-acetylbenzidine (AcBz), 4-aminobiphenyl (4ABP), aniline. 4ABP and aniline were quantitatively the major adducts. In the exposed workers (n = 33) all correlations between 4ABP, Bz and AcBz were r = 0.89 (P < 0.01) or greater. The group of workers exposed to Bz (Bz workers, n = 15) had 10-17-fold higher adduct levels than the workers exposed to dyes (dye workers, n = 18). 4ABP can be metabolically released from Bz and azo dyes. Aniline can be metabolically released from azo dyes. Therefore, the presence of 4ABP and aniline as Hb adducts is a consequence of exposure to the parent compounds or to the exposure of Bz and azo dyes and a consequent metabolical release of the arylamine moiety. The mean adduct ratios of 4ABP/(AcBz + Bz) varied up to 4-fold across all seven factories. Therefore, it is possible that 4ABP may have derived from general contamination in the work environment or endogenous metabolism, or a combination of the two. Since 4ABP is also a known human carcinogen, tumors observed in workers exposed to Bz or Bz dyes might be caused by both compounds. Further, these results suggest that understanding the role that genetic variants in NAT1 and NAT2 play in modifying the impact of Bz on bladder cancer risk may be complicated, as N-acetylation detoxifies 4ABP and activates Bz. JF - Carcinogenesis AU - Beyerbach, Armin AU - Rothman, Nathaniel AU - Bhatnagar, Vijai K AU - Kashyap, Rekha AU - Sabbioni, Gabriele AD - Institute of Environmental and Occupational Toxicology Casella Postale 108, CH-6780 Airolo, Switzerland. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, 20892, USA. National Institute of Occupational Health Ahmedabad, India. Walther-Straub-Institut fuer Pharmakologie und Toxikologie, Ludwig-Maximilians-Universitaet Muenchen Nussbaumstrasse 26, 80336 Muenchen, Germany Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1600 EP - 1606 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - N-Acetylbenzidine KW - Contamination KW - Azo dyes KW - Urinary bladder KW - Adducts KW - Tumors KW - Carcinogens KW - Cancer KW - Hemoglobin KW - Dyes KW - Carcinogenesis KW - Metabolism KW - Occupational exposure KW - Aniline KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19364928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hemoglobin+adducts+in+workers+exposed+to+benzidine+and+azo+dyes&rft.au=Beyerbach%2C+Armin%3BRothman%2C+Nathaniel%3BBhatnagar%2C+Vijai+K%3BKashyap%2C+Rekha%3BSabbioni%2C+Gabriele&rft.aulast=Beyerbach&rft.aufirst=Armin&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - N-Acetylbenzidine; Contamination; Urinary bladder; Azo dyes; Adducts; Carcinogens; Tumors; Cancer; Hemoglobin; Dyes; Carcinogenesis; Occupational exposure; Metabolism; Aniline ER - TY - JOUR T1 - Analysis of secA1 Gene Sequences for Identification of Nocardia Species AN - 19362620; 7131836 AB - Molecular methodologies, especially 16S rRNA gene sequence analysis, have allowed the recognition of many new species of Nocardia and to date have been the most precise methods for identifying isolates reliably to the species level. We describe here a novel method for identifying Nocardia isolates by using sequence analysis of a portion of the secA1 gene. A region of the secA1 gene of 30 type or reference strains of Nocardia species was amplified using secA1-specific primers. Sequence analysis of 468 bp allowed clear differentiation of all species, with a range of interspecies similarity of 85.0% to 98.7%. Corresponding 16S rRNA gene sequences of a 1,285-bp region for the same isolates showed a range of interspecies similarity of 94.4 to 99.8%. In addition to the type and reference strains, a 468-bp fragment of the secA1 gene was sequenced from 40 clinical isolates of 12 Nocardia species previously identified by 16S rRNA gene sequence analysis. The secA1 gene sequences of most isolates showed >99.0% similarity to the secA1 sequences of the type or reference strain to which their identification corresponded, with a range of 95.3 to 100%. Comparison of the deduced 156 amino acid sequences of the SecA1 proteins of the clinical isolates showed between zero and two amino acid residue differences compared to that of the corresponding type or reference strain. Sequencing of the secA1 gene, and using deduced amino acid sequences of the SecA1 protein, may provide a more discriminative and precise method for the identification of Nocardia isolates than 16S rRNA gene sequencing. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Zelazny, Adrian M AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2760 EP - 2766 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 8 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Differentiation KW - Primers KW - Nocardia KW - rRNA 16S KW - New species KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19362620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Analysis+of+secA1+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BZelazny%2C+Adrian+M%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2006-08-01&rft.volume=44&rft.issue=8&rft.spage=2760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Differentiation; Primers; rRNA 16S; New species; Nocardia ER - TY - JOUR T1 - Arsenic Induces NAD(P)H-quinone Oxidoreductase I by Disrupting the Nrf2.Keap1.Cul3 Complex and Recruiting Nrf2.Maf to the Antioxidant Response Element Enhancer AN - 19328853; 7061610 AB - The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adaptive responses in mammalian species. The biological targets of arsenic are largely unknown at present. We analyzed the signaling pathway for induction of detoxification gene NAD(P)H-quinone oxidoreductase (Nqo1) by arsenic. Genetic and biochemical evidence revealed that induction required cap `n' collar basic leucine zipper transcription factor Nrf2 and the antioxidant response element (ARE) of Nqo1. Arsenic stabilized Nrf2 protein, extending the t one half of Nrf2 from 21 to 200 min by inhibiting the Keap1.Cul3-dependent ubiquitination and proteasomal turnover of Nrf2. Arsenic markedly inhibited the ubiquitination of Nrf2 but did not disrupt the Nrf2.Keap1.Cul3 association in the cytoplasm. In the nucleus, arsenic, but not phenolic antioxidant tert-butylhydroquinone, dissociated Nrf2 from Keap1 and Cul3 followed by dimerization of Nrf2 with a Maf protein (Maf G/Maf K). Chromatin immunoprecipitation demonstrated that Nrf2 and Maf associated with the endogenous Nqo1 ARE enhancer constitutively. Arsenic substantially increased the ARE occupancy by Nrf2 and Maf. In addition, Keap1 was shown to be ubiquitinated in the cytoplasm and deubiquitinated in the nucleus in the presence of arsenic without changing the protein level, implicating nuclear-cytoplasmic recycling of Keap1. Our data reveal that arsenic activates the Nrf2/Keap1 signaling pathway through a distinct mechanism from that by antioxidants and suggest an "on-switch" model of Nqo1 transcription in which the binding of Nrf2.Maf to ARE controls both the basal and inducible expression of Nqo1. JF - Journal of Biological Chemistry AU - He, Xiaoqing AU - Chen, Michael G AU - Lin, Gary X AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 23620 EP - 23631 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 33 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts KW - Detoxification KW - Arsenic KW - Antioxidants KW - Chromatin KW - Regulatory sequences KW - Immunoprecipitation KW - NRF2 protein KW - Recycling KW - Maf protein KW - Models KW - Enhancers KW - ubiquitination KW - Transcription factors KW - Cytoplasm KW - oxidoreductase KW - phenolic compounds KW - NAD(P)H dehydrogenase (quinone) KW - Leucine zipper proteins KW - Nuclei KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19328853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Arsenic+Induces+NAD%28P%29H-quinone+Oxidoreductase+I+by+Disrupting+the+Nrf2.Keap1.Cul3+Complex+and+Recruiting+Nrf2.Maf+to+the+Antioxidant+Response+Element+Enhancer&rft.au=He%2C+Xiaoqing%3BChen%2C+Michael+G%3BLin%2C+Gary+X%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2006-08-01&rft.volume=281&rft.issue=33&rft.spage=23620&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Detoxification; Arsenic; Antioxidants; Chromatin; Regulatory sequences; Immunoprecipitation; NRF2 protein; Maf protein; Recycling; Models; ubiquitination; Enhancers; Cytoplasm; Transcription factors; phenolic compounds; oxidoreductase; NAD(P)H dehydrogenase (quinone); Leucine zipper proteins; Nuclei; Signal transduction ER - TY - JOUR T1 - Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles AN - 19327415; 7070914 AB - Diesel exhaust particles (DEPs) have been shown to activate oxidant generation by alveolar macrophages (AMs), alter xenobiotic metabolic pathways, and modify the balance of pro-antiinflammatory cytokines. In this study we investigated the role of nitric oxide (NO) in DEP-mediated and DEP organic extract (DEPE)-mediated inflammatory responses and evaluated the interaction of inducible NO synthase (iNOS) and cytochrome P450 1A1 (CYP1A1). Male Sprague-Dawley rats were intratracheally (IT) instilled with saline, DEPs (35 mg/kg), or DEPEs (equivalent to 35 mg DEP/kg), with or without further treatment with an iNOS inhibitor, aminoguanidine (AG; 100 mg/kg), by intraperitoneal injection 30 min before and 3, 6, and 9 hr after IT exposure. At 1 day postexposure, both DEPs and DEPEs induced iNOS expression and NO production by AMs. AG significantly lowered DEP- and DEPE-induced iNOS activity but not the protein level while attenuating DEPE- but not DEP-mediated pulmonary inflammation, airway damage, and oxidant generation by AMs. DEP or DEPE exposure resulted in elevated secretion of both interleukin (IL)-12 and IL-10 by AMs. AG significantly reduced DEP- and DEPE-activated AMs in IL-12 production. In comparison, AG inhibited IL-10 production by DEPE-exposed AMs but markedly increased its production by DEP-exposed AMs, suggesting that NO differentially regulates the pro- and antiinflammatory cytokine balance in the lung. Both DEPs and DEPEs induced CYP1A1 expression. AG strongly inhibited CYP1A1 activity and lung S9 activity-dependent 2-aminoanthracene mutagenicity. These studies show that NO plays a major role in DEPE-induced lung inflammation and CYP-dependent mutagen activation but a lesser role in particulate-induced inflammatory damage. JF - Environmental Health Perspectives AU - Zhao, Hongwen AU - Barger, M W AU - Ma, JKH AU - Castranova, V AU - Ma, JYC AD - Pathology and Physiology Research Branch, HELD, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA, jym1@cdc.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1253 EP - 1258 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Macrophages KW - Mutagens KW - Cooperation KW - Environmental health KW - Particulates KW - Xenobiotics KW - Interleukin 10 KW - Rats KW - Interleukin 12 KW - Metabolic pathways KW - Cytokines KW - Exhaust emissions KW - Respiratory tract KW - Mutagenicity KW - 2-Aminoanthracene KW - Exhausts KW - Inflammation KW - Nitric-oxide synthase KW - Cytochrome KW - Lung KW - Proteins KW - Diesel KW - Nitric oxide KW - Cytochrome P450 KW - Oxidants KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19327415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cooperation+of+the+Inducible+Nitric+Oxide+Synthase+and+Cytochrome+P450+1A1+in+Mediating+Lung+Inflammation+and+Mutagenicity+Induced+by+Diesel+Exhaust+Particles&rft.au=Zhao%2C+Hongwen%3BBarger%2C+M+W%3BMa%2C+JKH%3BCastranova%2C+V%3BMa%2C+JYC&rft.aulast=Zhao&rft.aufirst=Hongwen&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Mutagens; Mutagenicity; Cooperation; Xenobiotics; 2-Aminoanthracene; Interleukin 10; Inflammation; Exhausts; Nitric-oxide synthase; Interleukin 12; Lung; Metabolic pathways; Cytokines; Nitric oxide; Diesel; Cytochrome P450; Oxidants; Respiratory tract; Rats; Cytochrome; Proteins; Environmental health; Particulates; Exhaust emissions DO - http://dx.doi.org/10.1289/ehp.9063 ER - TY - JOUR T1 - Hierarchical models for probabilistic dose-response assessment AN - 19297085; 7042919 AB - Probabilistic risk assessment is gaining acceptance as the most appropriate way to characterize and communicate uncertainties in estimates of human health risk and/or reference levels of exposure such as benchmark doses. Although probabilistic techniques are well established in the exposure-assessment component of the National Research Council's risk-assessment paradigm, they are less well developed in the dose-response-assessment component. This paper proposes the use of hierarchical statistical models as tools for implementing probabilistic dose-response assessments, in that such models provide a natural connection between the pharmacokinetic (PK) and pharmacodynamic (PD) components of dose-response models. The results show that incorporating internal dose information into dose-response assessments via the coupling of PK and PD models in a hierarchical structure can reduce the uncertainty in the dose-response assessment of risk. However, information on the mean of the internal dose distribution is sufficient; having information on the variance of internal dose does not affect the uncertainty in the resulting estimates of excess risks or benchmark doses. In addition, the complexity of a PK model of internal dose does not affect how the variability in risk is measured via the ultimate endpoint. JF - Regulatory Toxicology and Pharmacology AU - Kodell, R L AU - Chen, J J AU - Delongchamp, R R AU - Young, J F AD - National Center for Toxicological Research, 3900 NCTR Road, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, rkodell@nctr.fda.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 265 EP - 272 PB - Elsevier Inc. VL - 45 IS - 3 SN - 0273-2300, 0273-2300 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Risk assessment KW - Mathematical models KW - Dose-response effects KW - Statistical analysis KW - Pharmacokinetics KW - Pharmacodynamics KW - H 14000:Toxicology KW - R2 23060:Medical and environmental health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19297085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Hierarchical+models+for+probabilistic+dose-response+assessment&rft.au=Kodell%2C+R+L%3BChen%2C+J+J%3BDelongchamp%2C+R+R%3BYoung%2C+J+F&rft.aulast=Kodell&rft.aufirst=R&rft.date=2006-08-01&rft.volume=45&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2006.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mathematical models; Statistical analysis; Pharmacodynamics; Pharmacokinetics; Dose-response effects DO - http://dx.doi.org/10.1016/j.yrtph.2006.05.002 ER - TY - JOUR T1 - Exposure to school children as a risk factor in a community outbreak of hepatitis A in young adults: a case control study AN - 19284284; 7026779 AB - To investigate risk factors during a community outbreak of hepatitis A we carried out a case- control study of 35 cases and 49 matched controls using an interviewer-administered questionnaire on clinical history, travel, household details including domestic toilet facilities, infectious contacts, and food history. Of 99 cases notified in the city during the outbreak year, 50 (51%) were young adults age 15-34 years. Hepatitis A infection was independently associated with household contact with a case (P=0.0005), and sharing a household with children in primary school (OR 3.4, 95% CI 1.2-9.5, P=0.008) with risk increasing with number of primary-school pupils in the household (X super(2) for linear trend 6.47, P=0.01). We concluded that in a population with a low prevalence of hepatitis A, adults who live in the same household as primary-school-age children are at increased risk of acquiring the infection during community outbreaks. JF - Epidemiology and Infection AU - Roberts, R J AU - Palmer AD - National Public Health Service, Preswylfa, Mold, Flintshire, UK, richard.roberts@nphs.wales.nhs.uk Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 803 EP - 807 PB - Cambridge University Press, UK, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 134 IS - 4 SN - 0950-2688, 0950-2688 KW - Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - Travel KW - Historical account KW - Inventories KW - Toilets KW - Food KW - Hepatitis A virus KW - outbreaks KW - Children KW - Infection KW - hepatitis A KW - infectious diseases KW - Schools KW - Risk factors KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Exposure+to+school+children+as+a+risk+factor+in+a+community+outbreak+of+hepatitis+A+in+young+adults%3A+a+case+control+study&rft.au=Roberts%2C+R+J%3BPalmer&rft.aulast=Roberts&rft.aufirst=R&rft.date=2006-08-01&rft.volume=134&rft.issue=4&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268805005625 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Travel; Risk assessment; Inventories; Toilets; Food; Risk factors; Infection; Children; Historical account; infectious diseases; Schools; outbreaks; hepatitis A; Hepatitis A virus DO - http://dx.doi.org/10.1017/S0950268805005625 ER - TY - JOUR T1 - Determining the microbiological criteria for lot rejection from the performance objective or food safety objective AN - 17271463; 6989901 AB - The Microbiological Criteria (MC) is a set of parameters used to determine whether a specific lot of food is acceptable or not. These parameters are the microbial test protocol and its sensitivity, the confidence level that an unacceptable lot will be detected, the number of samples to be taken and the number of positive samples that are allowed before rejecting the lot. Determining the microbiological criteria begins with knowledge of the distribution of contamination from samples within a lot, particularly within a lot that is just at the unacceptable level of the microbial hazard. The just unacceptable lot can be defined by the Food Safety Objective (FSO) or Performance Objectives (PO), the small fraction of samples that can exceed these values and the standard deviation of the samples from the lot. With this information, a microbial test protocol is chosen to have a sensitivity level that would detect between approximately 15% and 45% of the samples. A confidence level for the MC and the number of positive samples that would be acceptable (c value which is usually zero) are also chosen. With this information the number of samples (n) required can be calculated. A critical factor in setting the microbiological criteria is the sensitivity of the microbiological test (m value). The sample size (weight) and sampling procedure can affect the standard deviation of the samples, particularly foods with non-homogeneous distribution and low numbers of microorganisms. Sampling, sample preparation and analytical procedures that reduce the variation between the samples will affect the choice of m value and maximum lot mean that meets the MC. JF - International Journal of Food Microbiology AU - Whiting, R C AU - Rainosek, A AU - Buchanan, R L AU - Miliotis, M AU - LaBarre, D AU - Long, W AU - Ruple, A AU - Schaub, S AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA, richard.whiting@fda.hhs.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 263 EP - 267 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 110 IS - 3 SN - 0168-1605, 0168-1605 KW - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Risk analysis KW - Risk assessment KW - Attribute testing KW - Standard deviation KW - Microorganisms KW - Standards KW - Microbial contamination KW - Sampling KW - Food contamination KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17271463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Determining+the+microbiological+criteria+for+lot+rejection+from+the+performance+objective+or+food+safety+objective&rft.au=Whiting%2C+R+C%3BRainosek%2C+A%3BBuchanan%2C+R+L%3BMiliotis%2C+M%3BLaBarre%2C+D%3BLong%2C+W%3BRuple%2C+A%3BSchaub%2C+S&rft.aulast=Whiting&rft.aufirst=R&rft.date=2006-08-01&rft.volume=110&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2006.04.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Standard deviation; Microorganisms; Sampling; Food contamination; Standards; Microbial contamination DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2006.04.038 ER - TY - JOUR T1 - Increased susceptibility of the lungs of hyperthyroid rats to oxidant injury: Specificity of effects AN - 17256118; 6989387 AB - Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. This observation raised the possibility that pulmonary damage from other oxidant substances might be greater in a hyperthyroid state. To address this hypothesis, pulmonary responses to crystalline silica, a particulate with oxidant properties, were evaluated in normal or hyperthyroid adult male rats. To induce a hyperthyroid condition, time-release pellets containing thyroxine were implanted subcutaneously; control rats received placebo pellets. After 7 days, the animals were exposed to saline or silica (0.1 mg/100 g BW or 1.0 mg/100 g BW) by intratracheal instillation. Following silica treatment, there was a dose-related increase in bronchoalveolar lavage (BAL) albumin levels and neutrophil numbers. However, the effects of silica were similar in both normal and hyperthyroid rats. These findings were confirmed and contrasted with those regarding ozone (1 ppm, 4 h inhalation) in a subsequent experiment. The results indicated that, although exposure to either ozone or silica resulted in increases in BAL albumin levels and neutrophil numbers, only responses to ozone were enhanced in hyperthyroid rats. These findings suggest that specificity exists in regards to the modulation of oxidant-induced lung damage and inflammation by thyroid hormones. JF - Toxicology AU - Huffman, L J AU - Beighley, C M AU - Frazer, D G AU - McKinney, W G AU - Porter, D W AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S 2015, 1095 Willowdale Road, Morgantown, WV 26505, United States, DPorter@cdc.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 119 EP - 127 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 225 IS - 2-3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Silica KW - Ozone KW - Thyroid hormone KW - Rat KW - Inhalation KW - Injuries KW - Leukocytes (neutrophilic) KW - Toxicity KW - Alveoli KW - Inflammation KW - Thyroid hormones KW - Bronchus KW - Lung KW - Albumin KW - Thyroxine KW - Trachea KW - Oxidants KW - Hyperthyroidism KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17256118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Increased+susceptibility+of+the+lungs+of+hyperthyroid+rats+to+oxidant+injury%3A+Specificity+of+effects&rft.au=Huffman%2C+L+J%3BBeighley%2C+C+M%3BFrazer%2C+D+G%3BMcKinney%2C+W+G%3BPorter%2C+D+W&rft.aulast=Huffman&rft.aufirst=L&rft.date=2006-08-01&rft.volume=225&rft.issue=2-3&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2006.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Injuries; Leukocytes (neutrophilic); Toxicity; Alveoli; Inflammation; Thyroid hormones; Silica; Bronchus; Lung; Albumin; Thyroxine; Trachea; Hyperthyroidism; Oxidants; Ozone DO - http://dx.doi.org/10.1016/j.tox.2006.05.008 ER - TY - JOUR T1 - Understanding recombinant expression of membrane proteins AN - 17044927; 7003405 AB - Over the past 15 years, numerous reports have been published on the recombinant expression of integral membrane proteins. Some proteins accumulate in the membrane to high levels, whereas other often closely related proteins are barely detected. Understanding the underlying reasons for this variation has proven difficult. Recent studies in this area have provided new insight into the response of host cells to membrane protein expression and into the mechanism of membrane insertion. The successful overproduction of some membrane proteins was shown to be linked to the avoidance of stress responses in the host cell. Furthermore, the cell response to membrane protein production has been quantified and several genes that are either upregulated or downregulated when yields of a membrane-inserted protein are poor were identified. Progress has also been made in understanding how the translocon, which is the site of protein translocation and membrane insertion, decides whether a protein segment is integrated into the membrane or not. Building upon such experiments will lead to targeted approaches for recombinant membrane protein expression. JF - Current Opinion in Biotechnology AU - Grisshammer, Reinhard AD - super(a)Laboratory of Molecular Biology of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA, rkgriss@helix.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 337 EP - 340 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Protein transport KW - Protein biosynthesis KW - Reviews KW - Stress KW - Membrane proteins KW - W3 33340:Other proteins, peptides, amino acids KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17044927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Understanding+recombinant+expression+of+membrane+proteins&rft.au=Grisshammer%2C+Reinhard&rft.aulast=Grisshammer&rft.aufirst=Reinhard&rft.date=2006-08-01&rft.volume=17&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Protein biosynthesis; Reviews; Stress; Membrane proteins DO - http://dx.doi.org/10.1016/j.copbio.2006.06.001 ER - TY - CPAPER T1 - Bioinformatics, the Multiple-Biomarker Classifier Problem, Complexity, and Uncertainty T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40216709; 4342198 JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Wagner, R F Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=Bioinformatics%2C+the+Multiple-Biomarker+Classifier+Problem%2C+Complexity%2C+and+Uncertainty&rft.au=Wagner%2C+R+F&rft.aulast=Wagner&rft.aufirst=R&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - In situ structure characterization of airborne carbon nanofibres by a tandem mobility-mass analysis. AN - 733576648; 19661613 AB - Carbon nanofibres aerosolized by the agitation of as-produced commercial powder have been characterized in situ by using the differential mobility analyser-aerosol particle mass analyser (DMA-APM) method to determine their structural properties such as the effective density and fractal dimension for toxicology study. The effective density of the aerosolized carbon nanofibres decreased from 1.2 to 0.4 g cm(-3) as the mobility diameters increased from 100 to 700 nm, indicating that the carbon nanofibres had open structures with an overall void that increased with increasing diameter, due to increased agglomeration of the nanofibres. This was confirmed by transmission electron microscopy (TEM) observation, showing that 100 nm mobility diameter nanofibres were predominantly single fibres, while doubly or triply attached fibres were seen at mobility diameters of 200 and 400 nm. Effective densities calculated using Cox's theory were in reasonable agreement with experimental values. The mass fractal dimension of the carbon nanofibres was found to be 2.38 over the size range measured and higher than that of single-walled carbon nanotubes (SWCNTs), suggesting that the carbon nanofibres have more compact structure than SWCNTs. JF - Nanotechnology AU - Ku, Bon Ki AU - Emery, Mark S AU - Maynard, Andrew D AU - Stolzenburg, Mark R AU - McMurry, Peter H AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA. Y1 - 2006/07/28/ PY - 2006 DA - 2006 Jul 28 SP - 3613 EP - 3621 VL - 17 IS - 14 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733576648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotechnology&rft.atitle=In+situ+structure+characterization+of+airborne+carbon+nanofibres+by+a+tandem+mobility-mass+analysis.&rft.au=Ku%2C+Bon+Ki%3BEmery%2C+Mark+S%3BMaynard%2C+Andrew+D%3BStolzenburg%2C+Mark+R%3BMcMurry%2C+Peter+H&rft.aulast=Ku&rft.aufirst=Bon&rft.date=2006-07-28&rft.volume=17&rft.issue=14&rft.spage=3613&rft.isbn=&rft.btitle=&rft.title=Nanotechnology&rft.issn=1361-6528&rft_id=info:doi/10.1088%2F0957-4484%2F17%2F14%2F042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1088/0957-4484/17/14/042 ER - TY - JOUR T1 - Development of multiclass methods for drug residues in eggs: hydrophilic solid-phase extraction cleanup and liquid chromatography/tandem mass spectrometry analysis of tetracycline, fluoroquinolone, sulfonamide, and beta-lactam residues. AN - 68647499; 16848505 AB - A method was developed for detection of a variety of polar drug residues in eggs via liquid chromatography/tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). A total of twenty-nine target analytes from four drug classes-sulfonamides, tetracyclines, fluoroquinolones, and beta-lactams-were extracted from eggs using a hydrophilic-lipophilic balance polymer solid-phase extraction (SPE) cartridge. The extraction technique was developed for use at a target concentration of 100 ng/mL (ppb), and it was applied to eggs containing incurred residues from dosed laying hens. The ESI source was tuned using a single, generic set of tuning parameters, and analytes were separated with a phenyl-bonded silica cartridge column using an LC gradient. In a related study, residues of beta-lactam drugs were not found by LC/MS/MS in eggs from hens dosed orally with beta-lactam drugs. LC/MS/MS performance was evaluated on two generations of ion trap mass spectrometers, and key operational parameters were identified for each instrument. The ion trap acquisition methods could be set up for screening (a single product ion) or confirmation (multiple product ions). The lower limit of detection for screening purposes was 10-50 ppb (sulfonamides), 10-20 ppb (fluoroquinolones), and 10-50 ppb (tetracyclines), depending on the drug, instrument, and acquisition method. Development of this method demonstrates the feasibility of generic SPE, LC, and MS conditions for multiclass LC/MS residue screening. JF - Journal of agricultural and food chemistry AU - Heller, David N AU - Nochetto, Cristina B AU - Rummel, Nathan G AU - Thomas, Michael H AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA. david.heller@fda.hhs.gov Y1 - 2006/07/26/ PY - 2006 DA - 2006 Jul 26 SP - 5267 EP - 5278 VL - 54 IS - 15 SN - 0021-8561, 0021-8561 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Sulfonamides KW - Tetracyclines KW - beta-Lactams KW - Index Medicus KW - Fluoroquinolones -- analysis KW - Sulfonamides -- analysis KW - Animals KW - Chickens KW - Tetracyclines -- analysis KW - beta-Lactams -- analysis KW - Female KW - Spectrometry, Mass, Electrospray Ionization KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Eggs -- analysis KW - Anti-Bacterial Agents -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68647499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Development+of+multiclass+methods+for+drug+residues+in+eggs%3A+hydrophilic+solid-phase+extraction+cleanup+and+liquid+chromatography%2Ftandem+mass+spectrometry+analysis+of+tetracycline%2C+fluoroquinolone%2C+sulfonamide%2C+and+beta-lactam+residues.&rft.au=Heller%2C+David+N%3BNochetto%2C+Cristina+B%3BRummel%2C+Nathan+G%3BThomas%2C+Michael+H&rft.aulast=Heller&rft.aufirst=David&rft.date=2006-07-26&rft.volume=54&rft.issue=15&rft.spage=5267&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-29 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study. AN - 68572237; 16730138 AB - Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis. The first 18 patients received 1 g of intrarectal amifostine suspension placed 30-45 min before each radiation treatment. The following 12 patients received 2 g of amifostine. Total dose prescribed ranged from 66 to 76 Gy. All patients were treated with three-dimensional conformal radiation therapy. The suspension remained intrarectal during treatment and was expelled after treatment. For gastrointestinal symptoms, during treatment and follow-up, all patients had a Radiation Therapy Oncology Group (RTOG) grade recorded. Median follow-up was 18 months (range, 6-24 months). With 2 g vs. 1 g amifostine, there was a nearly significant decrease in RTOG Grade 2 acute rectal toxicity. Seven weeks after the start of radiation therapy, the incidence of Grade 2 toxicity was 33% in the 1-g group (6/18) compared with 0% (0/12) in the 2-g group (p=0.06). No Grade 3 toxicity or greater occurred in this study. This trial suggests greater rectal radioprotection from acute effects with 2 g vs. 1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis. JF - International journal of radiation oncology, biology, physics AU - Singh, Anurag K AU - Ménard, Cynthia AU - Guion, Peter AU - Simone, Nicole L AU - Smith, Sharon AU - Crouse, Nancy Sears AU - Godette, Denise J AU - Cooley-Zgela, Theresa AU - Sciuto, Linda C AU - Coleman, Jonathan AU - Pinto, Peter AU - Albert, Paul S AU - Camphausen, Kevin AU - Coleman, C Norman AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 1008 EP - 1013 VL - 65 IS - 4 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Radiotherapy, Conformal KW - Humans KW - Aged KW - Pilot Projects KW - Administration, Rectal KW - Statistics, Nonparametric KW - Male KW - Radiation-Protective Agents -- administration & dosage KW - Radiation Injuries -- prevention & control KW - Rectum -- radiation effects KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Proctitis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+suspension+may+protect+against+acute+proctitis+during+radiation+therapy+for+prostate+cancer%3A+a+pilot+study.&rft.au=Singh%2C+Anurag+K%3BM%C3%A9nard%2C+Cynthia%3BGuion%2C+Peter%3BSimone%2C+Nicole+L%3BSmith%2C+Sharon%3BCrouse%2C+Nancy+Sears%3BGodette%2C+Denise+J%3BCooley-Zgela%2C+Theresa%3BSciuto%2C+Linda+C%3BColeman%2C+Jonathan%3BPinto%2C+Peter%3BAlbert%2C+Paul+S%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-07-15&rft.volume=65&rft.issue=4&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Mutations of the Flavivirus Conserved 3_Squote_Sl in the West Nile Genome Result in Attenuation of Neurovirulence T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40218922; 4339243 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Yu, Li AU - Putnak, Robert AU - Pletnev, Alexander AU - Markoff, Lewis Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Mutation KW - Genomes KW - Neurovirulence KW - Flavivirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40218922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Mutations+of+the+Flavivirus+Conserved+3_Squote_Sl+in+the+West+Nile+Genome+Result+in+Attenuation+of+Neurovirulence&rft.au=Yu%2C+Li%3BPutnak%2C+Robert%3BPletnev%2C+Alexander%3BMarkoff%2C+Lewis&rft.aulast=Yu&rft.aufirst=Li&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Characterization of the Role of F and HN Surface Proteins in Neurovirulence of Mumps Virus Strains Urabe AM9 and 88-1961 using Reverse Genetics Technology T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40218621; 4339398 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Sauder, Christian AU - Vandenburgh, Kari AU - Zhang, Cheryl AU - Duprex, Paul AU - Carbone, Kathryn AU - Rubin, Steven Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Genetics KW - Mumps KW - Neurovirulence KW - Strains KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40218621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=In+Vivo+Characterization+of+the+Role+of+F+and+HN+Surface+Proteins+in+Neurovirulence+of+Mumps+Virus+Strains+Urabe+AM9+and+88-1961+using+Reverse+Genetics+Technology&rft.au=Sauder%2C+Christian%3BVandenburgh%2C+Kari%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Influenza Virus Gene Sequence Associated with Variability in Neurotoxicity T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40212932; 4339268 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Qi, Li AU - Carbone, Kathryn AU - Ye, Zhiping AU - Rubin, Steven Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Neurotoxicity KW - Influenza KW - Influenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40212932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Changes+in+Influenza+Virus+Gene+Sequence+Associated+with+Variability+in+Neurotoxicity&rft.au=Qi%2C+Li%3BCarbone%2C+Kathryn%3BYe%2C+Zhiping%3BRubin%2C+Steven&rft.aulast=Qi&rft.aufirst=Li&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repair of 3_Squote_-End Deletions in Dengue 2 Virus T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40206840; 4339559 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Teramoto, Tadahisa AU - Mattoo, Pravina AU - Kohno, Yukari AU - Padmanabhan, R AU - Markoff, Lewis AU - Falgout, Barry Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Deletion KW - Dengue virus type 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40206840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Inhibition+of+mammalian+target+of+rapamycin+modulates+expression+of+adhesion+molecules+in+endothelial+cells&rft.au=Wood%2C+Steven+C%3BBushar%2C+Grace%3BTesfamariam%2C+Belay&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.009 L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis and the Role of dsRNA Activated Mechanisms in HAV 18F Infected Frhk4 Cells T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40205280; 4339910 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Kulka, M AU - Goswami, B AU - Ayodeji, M AU - Ngo, D AU - Cebula, T Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Double-stranded RNA KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40205280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Apoptosis+and+the+Role+of+dsRNA+Activated+Mechanisms+in+HAV+18F+Infected+Frhk4+Cells&rft.au=Kulka%2C+M%3BGoswami%2C+B%3BAyodeji%2C+M%3BNgo%2C+D%3BCebula%2C+T&rft.aulast=Kulka&rft.aufirst=M&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Evaluation of Genetic Stability of New Live WNV Vaccine Candidate by Hybridization with Microarrays of Overlapping Oligonucleotides T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40204993; 4339475 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Laassri, Majid AU - Alexander, Pletnev AU - Chumakov, Konstantin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Vaccines KW - Oligonucleotides KW - Hybridization KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40204993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Mutations+induced+by+carcinogenic+doses+of+aristolochic+acid+in+kidney+of+Big+Blue+transgenic+rats&rft.au=Chen%2C+Ling%3BMei%2C+Nan%3BYao%2C+Lei%3BChen%2C+Tao&rft.aulast=Chen&rft.aufirst=Ling&rft.date=2006-09-01&rft.volume=165&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2006.04.008 L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Partition Coefficients for Toxic Agents in Multiple Phase Foods: Separation of Raw Whole Milk T2 - 2006 Joint Annual Meeting of the American Dairy Science Association and American Society of Animal Science AN - 40136656; 4300621 JF - 2006 Joint Annual Meeting of the American Dairy Science Association and American Society of Animal Science AU - Schlesser, J E AU - Jablonski, J E AU - Mariappagoudar, P Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Milk KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40136656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+American+Society+of+Animal+Science&rft.atitle=Partition+Coefficients+for+Toxic+Agents+in+Multiple+Phase+Foods%3A+Separation+of+Raw+Whole+Milk&rft.au=Schlesser%2C+J+E%3BJablonski%2C+J+E%3BMariappagoudar%2C+P&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2006/Scientific_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacology and Toxicology of Peroxisome Proliferator Activated Receptor Agonists: Differential Apoptosis of Troglitazone and Rosiglitazone T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40250957; 4364587 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Rhee, Herman M Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Pharmacology KW - Apoptosis KW - Peroxisome proliferator-activated receptors KW - Rosiglitazone KW - Troglitazone KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40250957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Pharmacology+and+Toxicology+of+Peroxisome+Proliferator+Activated+Receptor+Agonists%3A+Differential+Apoptosis+of+Troglitazone+and+Rosiglitazone&rft.au=Rhee%2C+Herman+M&rft.aulast=Rhee&rft.aufirst=Kumar&rft.date=2006-09-01&rft.volume=46&rft.issue=9&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2006.00936.x L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Fluoroquinolones on the Cardiovascular System in Telemetered Conscious Dogs T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40249400; 4364644 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Hee, Lee Yun AU - Hwan, Choi Ki AU - Suk, Yun Jae AU - Deahyun, Cho AU - Joo-Il, Kim Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Cardiovascular system KW - Fluoroquinolones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40249400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Effects+of+Fluoroquinolones+on+the+Cardiovascular+System+in+Telemetered+Conscious+Dogs&rft.au=Hee%2C+Lee+Yun%3BHwan%2C+Choi+Ki%3BSuk%2C+Yun+Jae%3BDeahyun%2C+Cho%3BJoo-Il%2C+Kim&rft.aulast=Hee&rft.aufirst=Lee&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tracheal Epithelial Cell Shrinkage Induced by Hyperosmolar Solution T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40247974; 4366497 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Fedan, J S AU - Jing, Y AU - Dowdy, J A AU - Ismailoglu, U B Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Osmotic pressure KW - Epithelial cells KW - Atrophy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Tracheal+Epithelial+Cell+Shrinkage+Induced+by+Hyperosmolar+Solution&rft.au=Fedan%2C+J+S%3BJing%2C+Y%3BDowdy%2C+J+A%3BIsmailoglu%2C+U+B&rft.aulast=Darensburg&rft.aufirst=Tahera&rft.date=2006-09-01&rft.volume=12&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765606296271 L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Agencies Role in Educational Program Related to Drug Development and Regulatory Science T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40247541; 4364487 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Lesko, Lawrence J Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Drug development KW - Education KW - Governments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Regulatory+Agencies+Role+in+Educational+Program+Related+to+Drug+Development+and+Regulatory+Science&rft.au=Lesko%2C+Lawrence+J&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discussion on the Chinese, American and European Guidelines for the Medicines in the Treatment of Hypertension T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40243606; 4365090 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Lin, Yan AU - Zhen-gang, Wang Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Hypertension UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40243606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Discussion+on+the+Chinese%2C+American+and+European+Guidelines+for+the+Medicines+in+the+Treatment+of+Hypertension&rft.au=Lin%2C+Yan%3BZhen-gang%2C+Wang&rft.aulast=Lin&rft.aufirst=Yan&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Emerging issues in occupational safety and health. AN - 68855925; 16967836 AB - In developed countries, changes in the nature of work and the workforce may necessitate recalibrating the vision of occupational safety and health (OSH) researchers, practitioners, and policymakers to increase the focus on the most important issues. New methods of organizing the workplace, extensive labor contracting, expansion of service and knowledge sectors, increase in small business, aging and immigrant workers, and the continued existence of traditional hazards in high-risk sectors such as construction, mining, agriculture, health care, and transportation support the need to address: 1) broader consideration of the role and impact of work, 2) relationship between work and psychological dysfunction, 3) increased surveillance basis for research and intervention, 4) overcoming barriers to the conduct and use of epidemiologic research, 5) information and knowledge transfer and application, 6) economic issues in prevention, and 7) the global interconnectedness of OSH. These issues are offered to spur thinking as new national research agendas for OSH are considered for developed countries. JF - International journal of occupational and environmental health AU - Schulte, Paul A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226-1922, USA. PY - 2006 SP - 273 EP - 277 VL - 12 IS - 3 SN - 1077-3525, 1077-3525 KW - Index Medicus KW - Information Dissemination -- methods KW - International Cooperation KW - Humans KW - Occupational Diseases -- prevention & control KW - Employment -- trends KW - Employment -- economics KW - Occupational Diseases -- psychology KW - Occupational Health KW - Workplace -- standards KW - Workplace -- organization & administration KW - Public Policy KW - Workplace -- economics KW - Developed Countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68855925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Mycobacterium+tuberculosis+Delta+RD1+Delta+panCD%3A+A+safe+and+limited+replicating+mutant+strain+that+protects+immunocompetent+and+immunocompromised+mice+against+experimental+tuberculosis&rft.au=Sambandamurthy%2C+Vasan+K%3BDerrick%2C+Steven+C%3BHsu%2C+Tsungda%3BChen%2C+Bing%3BLarsen%2C+Michelle+H%3BJalapathy%2C+Kripa+V%3BChen%2C+Mei%3BKim%2C+John%3BPorcelli%2C+Steven+A%3BChan%2C+John%3BMorris%2C+Sheldon+L%3BJacobs%2C+William+R&rft.aulast=Sambandamurthy&rft.aufirst=Vasan&rft.date=2006-09-01&rft.volume=24&rft.issue=37-39&rft.spage=6309&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: Results of the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68714974; 16889449 AB - To present national data on the prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders for sedatives, tranquilizers, opioids, and amphetamines. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a face-to-face nationally representative survey of 43,093 adults conducted during 2001 and 2002. Lifetime prevalences of nonmedical use of sedatives, tranquilizers, opioids, and amphetamines were 4.1%, 3.4%, 4.7%, and 4.7%, respectively. Corresponding rates of abuse and/or dependence on these substances were 1.1%, 1.0%, 1.4%, and 2.0%. The odds of nonmedical prescription drug use and drug use disorders were generally greater among men, Native Americans, young and middle-aged, those who were widowed/ separated/divorced or never married, and those residing in the West. Abuse/dependence liability was greatest for amphetamines, and nonmedical prescription drug use disorders were highly comorbid with other Axis I and II disorders. The majority of individuals with non-medical prescription drug use disorders never received treatment. Nonmedical prescription drug use and disorders are pervasive in the U.S. population and highly comorbid with other psychiatric disorders. Native Americans had significantly greater rates of nonmedical prescription drug use and drug use disorders, highlighting the need for culturally-sensitive prevention and intervention programs. Unprecedented comorbidity between nonmedical prescription drug use disorders and between nonmedical prescription drug use disorders and illicit drug use disorders suggests that the typical individual abusing or dependent on these drugs obtained them illegally, rather than through a physician. Amphetamines had the greatest abuse/dependence liability, and recent increases in the potency of illegally manufactured amphetamines may portend an epidemic in the youngest NESARC cohort. JF - The Journal of clinical psychiatry AU - Huang, Boji AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Hasin, Deborah S AU - Ruan, W June AU - Saha, Tulshi D AU - Smith, Sharon M AU - Goldstein, Risë B AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1062 EP - 1073 VL - 67 IS - 7 SN - 0160-6689, 0160-6689 KW - Hypnotics and Sedatives KW - 0 KW - Psychotropic Drugs KW - Street Drugs KW - Tranquilizing Agents KW - Index Medicus KW - Amphetamine-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Humans KW - Street Drugs -- adverse effects KW - Health Surveys KW - Adult KW - Psychotropic Drugs -- adverse effects KW - Hypnotics and Sedatives -- adverse effects KW - Tranquilizing Agents -- adverse effects KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Drug Prescriptions -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68714974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+and+comorbidity+of+nonmedical+prescription+drug+use+and+drug+use+disorders+in+the+United+States%3A+Results+of+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Huang%2C+Boji%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BHasin%2C+Deborah+S%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BSmith%2C+Sharon+M%3BGoldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=67&rft.issue=7&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The indirect detection of bleach (sodium hypochlorite) in beverages as evidence of product tampering. AN - 68700509; 16882227 AB - Bleach (sodium hypochlorite) has been identified as the adulterant in a relatively large number of product tamperings that have been investigated by the Forensic Chemistry Center (FCC) of the U.S. Food and Drug Administration. In this work, household bleach was added to 23 different beverages at each of three levels. The impact of sodium hypochlorite on these beverages over a 13-day study period was evaluated using the following techniques: diphenylamine spot test for oxidizing agents, potassium iodide-starch test paper for oxidizing agents, pH, iodometric titration for quantitating hypochlorite, ion chromatography for chloride and chlorate quantitation, automated headspace sampling with gas chromatography-flame ionization detection (GC-FID) for determination of chloroform, and visual and organoleptic observations. This study has shown that hypochlorite is fragile when added to most common beverages and typically breaks down either partially or completely over time. In cases where a beverage is suspected of being adulterated with bleach but tests for hypochlorite are negative, it is still possible to characterize the product to demonstrate that the results are consistent with the addition of bleach. An adulterated product will give a positive test for oxidizing agents using the diphenylamine spot test. It is likely that the pH of the adulterated product will be higher than a control of that product. Ion chromatographic analysis shows elevated chloride and chlorate as compared with a control. And, chloroform may also be detected by GC-FID especially if the beverage that was adulterated contains citric acid. JF - Journal of forensic sciences AU - Jackson, David S AU - Crockett, David F AU - Wolnik, Karen A AD - Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, OH 45237, USA. david.jackson@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 827 EP - 831 VL - 51 IS - 4 SN - 0022-1198, 0022-1198 KW - Disinfectants KW - 0 KW - Sodium Hypochlorite KW - DY38VHM5OD KW - Index Medicus KW - Flame Ionization KW - Hydrogen-Ion Concentration KW - Chromatography, Ion Exchange KW - Disinfectants -- poisoning KW - Sodium Hypochlorite -- poisoning KW - Beverages -- analysis KW - Forensic Medicine -- methods KW - Sodium Hypochlorite -- chemistry KW - Disinfectants -- chemistry KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68700509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+forensic+sciences&rft.atitle=The+indirect+detection+of+bleach+%28sodium+hypochlorite%29+in+beverages+as+evidence+of+product+tampering.&rft.au=Jackson%2C+David+S%3BCrockett%2C+David+F%3BWolnik%2C+Karen+A&rft.aulast=Jackson&rft.aufirst=David&rft.date=2006-07-01&rft.volume=51&rft.issue=4&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Journal+of+forensic+sciences&rft.issn=00221198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMAM methods update: a laboratory response to concerns about technologically outdated and problematic methods. AN - 68640878; 16835165 AB - The National Institute for Occupational Safety Health (NIOSH) publishes the NIOSH Manual of Analytical Methods (NMAM). The NMAM, although subject to various revisions and the incorporation of supplemental editions over the years, still contains many methods that are technologically outdated or problematic, as identified in a recent survey of the various users of the NMAM. Whereas the survey identified a number of problematic methods based on various chromatographic techniques, those selected for inclusion in this project employed analysis by gas chromatography (GC). The GC methods selected for evaluation were categorized as Phases 1, 2, 3, and 4 based on necessity as determined by the results of the client survey or internal assessment. The Phase 1 methods included: NMAM 1606 (Acetonitrile), NMAM 2005 (Nitroaromatic Compounds), and NMAM 1453 (Vinyl Acetate); the Phase 2 methods: NMAM 1003 (Halogenated Hydrocarbons), NMAM 1501 (Aromatic Hydrocarbons), NMAM 2555 (Ketones I), and NMAM 1403 (Alcohols IV); the Phase 3 methods: NMAM 2552 (Methyl Acrylate), NMAM 2537 (Methyl and Ethyl Methacrylate), and NMAM 2553 (Ketones II), and the Phase 4 methods: NMAM 2556 (Isophorone), NMAM 1460 (Isopropyl Acetate), and NMAM 1618 (Isopropyl Ether). All methods previously specifying packed column chromatography have been evaluated using the appropriate fused silica capillary column. Improvements in individual analyte desorption efficiencies were achieved at concentrations substantially lower than those used in the previous methods. Most analytes evaluated had their respective limit of detection lowered by a factor of ten-to twentyfold. Thirty-day storage stability studies, previously lacking in a number of methods or for new analytes, were successfully completed to meet current method development criteria. Additional benefits resulting from this effort included the incorporation of single analyte methods into chemically related multianalyte methods and the evaluation of certain isomers, such as the methylstyrenes and xylenes, which previously could not be separated. JF - Journal of occupational and environmental hygiene AU - Pendergrass, Stephanie M AU - Ernst, Jennifer L AU - Dollberg, Donald D AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. smp5@cdc.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 390 EP - 396 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Air Pollution, Indoor -- analysis KW - Environmental Monitoring -- methods KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Chromatography, Gas -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68640878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=NMAM+methods+update%3A+a+laboratory+response+to+concerns+about+technologically+outdated+and+problematic+methods.&rft.au=Pendergrass%2C+Stephanie+M%3BErnst%2C+Jennifer+L%3BDollberg%2C+Donald+D&rft.aulast=Pendergrass&rft.aufirst=Stephanie&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of laboratory simulated road paving-like asphalt by high-performance liquid chromatography and gas chromatography-mass spectrometry. AN - 68634783; 16835160 AB - Prolonged, extensive exposure to asphalt fume has been associated with several adverse health effects. Inhaled polycyclic aromatic hydrocarbons (PAHs) from asphalt fume exposure are of concern. The objective of this study was to characterize both qualitative and quantitative differences between fumes generated at 150 degrees C and 180 degrees C using a well-controlled laboratory road paving fume generation system. Fumes were characterized by total volatile and particulate concentration, simulated boiling point profile, and specific PAH content. The mean concentrations of the volatile fractions generated at 180 degrees C and 150 degrees C were 23.3 mg/m3 and 11.2 mg/m3, respectively, demonstrating a statistically significant shift in concentration. The mean concentrations of the particulate fractions generated at 180 degrees C and 150 degrees C were 42.4 mg/m3 and 28.0 mg/m3, respectively. The simulated boiling point profile did not show a significant qualitative difference between the fumes generated at the two temperatures. Naphthalene, acenaphthene, fluorene, phenanthrene, fluoranthene, pyrene, and chrysene were identified and quantified from the fumes. JF - Journal of occupational and environmental hygiene AU - Law, Brandon F AU - Stone, Samuel AU - Frazer, David AU - Siegel, Paul D AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. bhl7@cdc.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 343 EP - 350 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Hydrocarbons KW - Polycyclic Compounds KW - asphalt KW - 8052-42-4 KW - Index Medicus KW - Transition Temperature KW - Air Pollutants, Occupational -- isolation & purification KW - Gas Chromatography-Mass Spectrometry KW - Volatilization KW - Occupational Exposure -- analysis KW - Chromatography, High Pressure Liquid KW - Polycyclic Compounds -- chemistry KW - Hydrocarbons -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68634783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Characterization+of+laboratory+simulated+road+paving-like+asphalt+by+high-performance+liquid+chromatography+and+gas+chromatography-mass+spectrometry.&rft.au=Law%2C+Brandon+F%3BStone%2C+Samuel%3BFrazer%2C+David%3BSiegel%2C+Paul+D&rft.aulast=Law&rft.aufirst=Brandon&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of multilocus sequence typing, pulsed-field gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates. AN - 68617516; 16825363 AB - In the United States, multidrug-resistant phenotypes of Salmonella enterica serotype Newport (commonly referred to as MDR-AmpC) have emerged in animals and humans and have become a major public health problem. Although pulsed-field gel electrophoresis (PFGE) is the current "gold standard" typing method for Salmonella, multilocus sequence typing (MLST) may be more relevant to investigations exploring evolutionary and population biology relationships. In this study, 81 Salmonella enterica serotype Newport isolates from humans, food animals, and retail foods were examined for antimicrobial susceptibility and characterized using PFGE and MLST of seven genes, aroC, dnaN, hemD, hisD, purE, sucA, and thrA. Forty-nine percent of the isolates were resistant to nine or more of the tested antimicrobials. Salmonella isolates displayed resistance most often to sulfamethoxazole (57%), streptomycin (56%), tetracycline (56%), ampicillin (52%), and ceftiofur (49%) and, to a lesser extent, to kanamycin (19%), trimethoprim-sulfamethoxazole (17%), and gentamicin (11%). A total of 43 PFGE patterns were generated using XbaI, indicating a genetically diverse population. The largest PFGE cluster contained isolates from clinically ill swine, cattle, and humans. MLST resulted in 12 sequence types (STs), with one type encompassing 62% of the strains. Ten new sequence types and one novel allele type were identified. Furthermore, MLST typing showed that strains closely related by PFGE clustered in major STs, whereas more distantly related strains were separated into two clusters by PFGE. The results of this study demonstrated that the MLST scheme employed here clustered S. enterica serovar Newport isolates in distinct molecular populations, and strain discrimination was enhanced by combining PFGE, antimicrobial susceptibility, and MLST results. JF - Journal of clinical microbiology AU - Harbottle, H AU - White, D G AU - McDermott, P F AU - Walker, R D AU - Zhao, S AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Rd., Laurel, MD 20708, USA. heather.harbottle@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 2449 EP - 2457 VL - 44 IS - 7 SN - 0095-1137, 0095-1137 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - endodeoxyribonuclease XBAI KW - EC 3.1.21.- KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - Index Medicus KW - Salmonella Infections, Animal -- microbiology KW - Animals KW - Genes, Bacterial KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Chickens -- microbiology KW - Serotyping KW - DNA Fingerprinting KW - Salmonella Infections -- microbiology KW - Drug Resistance, Multiple, Bacterial KW - Swine -- microbiology KW - Cattle KW - Turkeys -- microbiology KW - Food Microbiology KW - Polymorphism, Restriction Fragment Length KW - Meat Products -- microbiology KW - DNA, Bacterial -- chemistry KW - DNA, Bacterial -- genetics KW - Salmonella enterica -- isolation & purification KW - Salmonella enterica -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Sequence Analysis, DNA KW - Salmonella enterica -- classification KW - Bacterial Typing Techniques KW - Salmonella enterica -- drug effects KW - Microbial Sensitivity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68617516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+multilocus+sequence+typing%2C+pulsed-field+gel+electrophoresis%2C+and+antimicrobial+susceptibility+typing+for+characterization+of+Salmonella+enterica+serotype+Newport+isolates.&rft.au=Harbottle%2C+H%3BWhite%2C+D+G%3BMcDermott%2C+P+F%3BWalker%2C+R+D%3BZhao%2C+S&rft.aulast=Harbottle&rft.aufirst=H&rft.date=2006-07-01&rft.volume=44&rft.issue=7&rft.spage=2449&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Microbiol. 2003 Oct;11(10):479-87 [14557031] J Microbiol Methods. 2005 Nov;63(2):173-84 [16226640] J Clin Microbiol. 2003 Dec;41(12):5366-71 [14662912] Clin Infect Dis. 2003 Dec 15;37(12):1585-90 [14689335] Appl Environ Microbiol. 2004 Jan;70(1):318-23 [14711658] Int J Food Microbiol. 2004 Feb 15;91(1):51-62 [14967560] J Bacteriol. 2004 Mar;186(5):1518-30 [14973027] J Food Prot. 2004 Apr;67(4):651-7 [15083714] J Clin Microbiol. 2000 Mar;38(3):1008-15 [10698988] Appl Environ Microbiol. 2000 Dec;66(12):5273-81 [11097902] J Clin Microbiol. 2000 Dec;38(12):4492-8 [11101585] Emerg Infect Dis. 2001 May-Jun;7(3):382-9 [11384513] Avian Dis. 2001 Oct-Dec;45(4):875-86 [11785892] J Clin Microbiol. 2002 May;40(5):1626-35 [11980932] J Clin Microbiol. 2002 Jun;40(6):1963-71 [12037049] J Clin Microbiol. 2002 Dec;40(12):4544-6 [12454149] J Clin Microbiol. 2002 Dec;40(12):4679-84 [12454172] J Appl Microbiol. 2003;94(1):65-72 [12492925] J Clin Microbiol. 2003 Feb;41(2):675-9 [12574266] Emerg Infect Dis. 2003 Apr;9(4):496-9 [12702235] J Clin Microbiol. 2003 Sep;41(9):4270-8 [12958256] J Clin Microbiol. 2003 Sep;41(9):4279-84 [12958257] J Clin Microbiol. 2003 Oct;41(10):4578-82 [14532185] J Clin Microbiol. 2003 Oct;41(10):4833-5 [14532235] Clin Infect Dis. 2004 Apr 15;38 Suppl 3:S127-34 [15095181] MMWR Morb Mortal Wkly Rep. 2004 Apr 30;53(16):338-43 [15123986] J Clin Microbiol. 2004 May;42(5):2314-6 [15131222] Appl Environ Microbiol. 2004 Jul;70(7):4030-4 [15240279] Trends Microbiol. 2004 Aug;12(8):373-7 [15276613] Epidemiol Infect. 2004 Aug;132(4):571-7 [15310157] Appl Environ Microbiol. 2004 Sep;70(9):5305-14 [15345414] J Clin Microbiol. 2004 Sep;42(9):4275-83 [15365023] J Infect. 2004 Nov;49(4):291-6 [15474626] N Engl J Med. 1987 Mar 5;316(10):565-70 [3807951] J Clin Microbiol. 1988 Nov;26(11):2465-6 [3069867] J Med Microbiol. 1994 Jan;40(1):15-22 [7904649] Microbiol Immunol. 1995;39(9):673-6 [8577280] Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9869-74 [9275218] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3140-5 [9501229] Vet Microbiol. 1998 Mar 31;61(3):215-27 [9631533] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] J Clin Microbiol. 2004 Dec;42(12):5681-8 [15583299] J Clin Microbiol. 2004 Dec;42(12):5722-30 [15583305] J Clin Microbiol. 2005 Jan;43(1):340-7 [15634992] J Clin Microbiol. 2005 Mar;43(3):1205-9 [15750084] Ugeskr Laeger. 2005 Feb 14;167(7):764-6 [15779263] J Clin Microbiol. 2005 Apr;43(4):1604-11 [15814973] J Clin Microbiol. 2005 Apr;43(4):1776-81 [15814998] J Clin Microbiol. 2005 May;43(5):2215-9 [15872244] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W728-33 [15980573] J Clin Microbiol. 2005 Jul;43(7):3519-21 [16000495] J Clin Microbiol. 2005 Aug;43(8):3688-98 [16081897] Antimicrob Agents Chemother. 2005 Oct;49(10):4061-7 [16189081] J Infect Dis. 2003 Dec 1;188(11):1707-16 [14639542] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlates of public health workforce acceptance of smallpox immunization in Virginia. AN - 68602294; 16817805 AB - By October 24, 2003, 38,577 of 500,000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Cross-sectional survey, conducted in May 2004. We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Among nonvaccinees (n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees (n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6-85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1-22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6-81.1). Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed. JF - Public health nursing (Boston, Mass.) AU - Bryant-Genevier, Marthe AU - Sommer, Sandra AU - McMahon, Ann AU - Ball, Robert AU - Braun, M Miles AD - CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland 20852-1448, USA. marthe.bryant-genevier@fda.hhs.gov PY - 2006 SP - 339 EP - 346 VL - 23 IS - 4 SN - 0737-1209, 0737-1209 KW - Index Medicus KW - Nursing KW - Cross-Sectional Studies KW - Virginia KW - Humans KW - Adult KW - Disaster Planning KW - Aged KW - Middle Aged KW - Bioterrorism KW - Male KW - Female KW - Attitude of Health Personnel KW - Occupational Diseases -- prevention & control KW - Immunization Programs KW - Health Knowledge, Attitudes, Practice KW - Smallpox -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68602294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+nursing+%28Boston%2C+Mass.%29&rft.atitle=Correlates+of+public+health+workforce+acceptance+of+smallpox+immunization+in+Virginia.&rft.au=Bryant-Genevier%2C+Marthe%3BSommer%2C+Sandra%3BMcMahon%2C+Ann%3BBall%2C+Robert%3BBraun%2C+M+Miles&rft.aulast=Bryant-Genevier&rft.aufirst=Marthe&rft.date=2006-07-01&rft.volume=23&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Public+health+nursing+%28Boston%2C+Mass.%29&rft.issn=07371209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. AN - 68598132; 16815813 AB - The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins, which transport a variety of compounds through the membrane against a concentration gradient at the cost of ATP hydrolysis. Substrates of the ABC transporters include lipids, bile acids, xenobiotics, and peptides for antigen presentation. As they transport exogenous and endogenous compounds, they reduce the body load of potentially harmful substances. One by-product of such protective function is that they also eliminate various useful drugs from the body, causing drug resistance. This review is a brief summary of the structure, function, and expression of the important drug resistance-conferring members belonging to three subfamilies of the human ABC family; these are ABCB1 (MDR1/P-glycoprotein of subfamily ABCB), subfamily ABCC (MRPs), and ABCG2 (BCRP of subfamily ABCG), which are expressed in various organs. In the text, the transporter symbol that carries the subfamily name (such as ABCB1, ABCC1, etc.) is used interchangeably with the corresponding original names, such as MDR1P-glycoprotein, MRP1, etc., respectively. Both nomenclatures are maintained in the text because both are still used in the transporter literature. This helps readers relate various names that they encounter in the literature. It now appears that P-glycoprotein, MRP1, MRP2, and BCRP can explain the phenomenon of multidrug resistance in all cell lines analyzed thus far. Also discussed are the gene structure, regulation of expression, and various polymorphisms in these genes. Because genetic polymorphism is thought to underlie interindividual differences, including their response to drugs and other xenobiotics, the importance of polymorphism in these genes is also discussed. JF - International journal of toxicology AU - Choudhuri, Supratim AU - Klaassen, Curtis D AD - Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA. Suratim.Choudhuri@fda.hhs.gov PY - 2006 SP - 231 EP - 259 VL - 25 IS - 4 SN - 1091-5818, 1091-5818 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Neoplasm Proteins KW - P-Glycoprotein KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Biodegradation, Environmental KW - Genes, MDR -- genetics KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68598132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+toxicology&rft.atitle=Structure%2C+function%2C+expression%2C+genomic+organization%2C+and+single+nucleotide+polymorphisms+of+human+ABCB1+%28MDR1%29%2C+ABCC+%28MRP%29%2C+and+ABCG2+%28BCRP%29+efflux+transporters.&rft.au=Choudhuri%2C+Supratim%3BKlaassen%2C+Curtis+D&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2006-07-01&rft.volume=25&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=International+journal+of+toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic variability and the miracle of modern analytical chemistry. AN - 68593045; 16810094 JF - Epidemiology (Cambridge, Mass.) AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. longnec1@niehs.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 350 EP - 351 VL - 17 IS - 4 SN - 1044-3983, 1044-3983 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Humans KW - Cohort Studies KW - Body Mass Index KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Male KW - Female KW - Chemistry Techniques, Analytical -- methods KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68593045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Pharmacokinetic+variability+and+the+miracle+of+modern+analytical+chemistry.&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2006-07-01&rft.volume=17&rft.issue=4&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Epidemiology. 2006 Jul;17(4):352-9 [16755267] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. AN - 68587844; 16805835 AB - Although endogenous cannabinoid systems have been implicated in the modulation of the rewarding effects of abused drugs and food, little is known about the direct effects of endogenous ligands for cannabinoid receptors on brain reward processes. Here we show for the first time that the intravenous administration of anandamide, an endogenous ligand for cannabinoid receptors, and its longer-lasting synthetic analog methanandamide, increase the extracellular dopamine levels in the nucleus accumbens shell of awake, freely moving rats, an effect characteristic of most drugs abused by humans. Anandamide produced two distinctly different effects on dopamine levels: (1) a rapid, transient increase that was blocked by the cannabinoid CB1 receptor antagonist rimonabant, but not by the vanilloid VR1 receptor antagonist capsazepine, and was magnified and prolonged by the fatty acid amide hydrolase (FAAH) enzyme inhibitor, URB597; (2) a smaller delayed and long-lasting increase, not sensitive to CB1, VR1 or FAAH blockade. Both effects were blocked by infusing either tetrodotoxin (TTX, 1 microm) or calcium-free Ringer's solution through the microdialysis probe, demonstrating that they were dependent on the physiologic activation of dopaminergic neurotransmission. Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes. JF - Journal of neurochemistry AU - Solinas, Marcello AU - Justinova, Zuzana AU - Goldberg, Steven R AU - Tanda, Gianluigi AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 408 EP - 419 VL - 98 IS - 2 SN - 0022-3042, 0022-3042 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Cannabinoids KW - Carbamates KW - Endocannabinoids KW - Enzyme Inhibitors KW - Polyunsaturated Alkamides KW - Receptor, Cannabinoid, CB1 KW - TRPV Cation Channels KW - TRPV1 receptor KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Tetrodotoxin KW - 4368-28-9 KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - Calcium KW - SY7Q814VUP KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Carbamates -- pharmacology KW - Animals KW - TRPV Cation Channels -- drug effects KW - Synaptic Transmission -- drug effects KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Cannabinoids -- pharmacology KW - Microdialysis KW - Rats KW - Rats, Sprague-Dawley KW - Benzamides -- pharmacology KW - Calcium -- physiology KW - Data Interpretation, Statistical KW - Tetrodotoxin -- pharmacology KW - Male KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Amidohydrolases -- antagonists & inhibitors KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68587844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Anandamide+administration+alone+and+after+inhibition+of+fatty+acid+amide+hydrolase+%28FAAH%29+increases+dopamine+levels+in+the+nucleus+accumbens+shell+in+rats.&rft.au=Solinas%2C+Marcello%3BJustinova%2C+Zuzana%3BGoldberg%2C+Steven+R%3BTanda%2C+Gianluigi&rft.aulast=Solinas&rft.aufirst=Marcello&rft.date=2006-07-01&rft.volume=98&rft.issue=2&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. AN - 68072888; 16154368 AB - The fluoroquinolones are a class of compounds that comprise a large and expanding group of synthetic antimicrobial agents. Structurally, all fluoroquinolones contain a fluorine molecule at the 6-position of the basic quinolone nucleus. Despite the basic similarity in the core structure of these molecules, their physicochemical properties, pharmacokinetic characteristics and microbial activities can vary markedly across compounds. The first of the fluoroquinolones approved for use in animals, enrofloxacin, was approved in the late 1980s. Since then, five other fluoroquinolones have been marketed for use in animals in the United States, with others currently under investigation. This review focuses on the use of fluoroquinolones within veterinary medicine, providing an overview of the structure-activity relationship of the various members of the group, the clinical uses of fluoroquinolones in veterinary medicine, their pharmacokinetics and potential interspecies differences, an overview of the current understanding of the pharmacokinetic/pharmacodynamic relationships associated with fluoroquinolones, a summary of toxicities that have been associated with this class of compounds, their use in both in human and veterinary species, mechanisms associated with the development of microbial resistance to the fluoroquinolones, and a discussion of fluoroquinolone dose optimization. Although the review contains a large body of basic research information, it is intended that the contents of this review have relevance to both the research scientist and the veterinary medical practitioner. JF - Veterinary journal (London, England : 1997) AU - Martinez, Marilyn AU - McDermott, Patrick AU - Walker, Robert AD - US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 20855, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 10 EP - 28 VL - 172 IS - 1 SN - 1090-0233, 1090-0233 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Veterinary Drugs KW - Index Medicus KW - Animals, Domestic KW - Animals KW - Drug Resistance, Bacterial KW - Drug Approval KW - Legislation, Drug KW - Species Specificity KW - Anti-Bacterial Agents -- therapeutic use KW - Animal Diseases -- drug therapy KW - Fluoroquinolones -- therapeutic use KW - Anti-Bacterial Agents -- pharmacology KW - Fluoroquinolones -- pharmacokinetics KW - Fluoroquinolones -- pharmacology KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68072888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+journal+%28London%2C+England+%3A+1997%29&rft.atitle=Pharmacology+of+the+fluoroquinolones%3A+a+perspective+for+the+use+in+domestic+animals.&rft.au=Martinez%2C+Marilyn%3BMcDermott%2C+Patrick%3BWalker%2C+Robert&rft.aulast=Martinez&rft.aufirst=Marilyn&rft.date=2006-07-01&rft.volume=172&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Veterinary+journal+%28London%2C+England+%3A+1997%29&rft.issn=10900233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-21 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002. AN - 68070008; 16769298 AB - The objective of this study was to compare the current prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and mood, anxiety, and personality disorders among whites, blacks, Native Americans, Asians, and Hispanics in a large representative sample of the US population. Striking mental health disparities were observed in the prevalences of psychiatric disorders, especially among Native Americans. Disparities in psychiatric comorbidity differed from those associated with prevalence. Most significantly, the association between alcohol disorders and personality disorders was significantly greater among Asians relative to whites, blacks, and Native Americans, despite lower prevalences of these disorders among Asians. Taken together, the results of this study highlight the need of future studies that help unravel the risk factors underlying the disparities in both prevalence and comorbidity of psychiatric disorders observed among race-ethnic groups in the United States. JF - Comprehensive psychiatry AU - Huang, Boji AU - Grant, Bridget F AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Chou, S Patricia AU - Saha, Tulshi D AU - Goldstein, Risë B AU - Smith, Sharon M AU - Ruan, W June AU - Pickering, Roger P AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA. HuangBo@mail.nih.gov PY - 2006 SP - 252 EP - 257 VL - 47 IS - 4 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Personality Disorders -- epidemiology KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Alcoholism -- ethnology KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Mental Disorders -- ethnology KW - Substance-Related Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68070008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Race-ethnicity+and+the+prevalence+and+co-occurrence+of+Diagnostic+and+Statistical+Manual+of+Mental+Disorders%2C+Fourth+Edition%2C+alcohol+and+drug+use+disorders+and+Axis+I+and+II+disorders%3A+United+States%2C+2001+to+2002.&rft.au=Huang%2C+Boji%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BChou%2C+S+Patricia%3BSaha%2C+Tulshi+D%3BGoldstein%2C+Ris%C3%AB+B%3BSmith%2C+Sharon+M%3BRuan%2C+W+June%3BPickering%2C+Roger+P&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=47&rft.issue=4&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race/ethnic differences in the prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68046980; 16650344 AB - Very few large national epidemiologic surveys have examined the prevalence of psychiatric disorders among Asians and Native Americans due to small sample sizes. Very little is also known about the co-occurrences between substance use disorders and mood and anxiety disorders among these two minority groups and how their rates compare to Whites, Blacks, and Hispanics. Analyses were based on a large (n = 43093) nationally representative survey of the adult (18+ years), U.S. population supplemented by a group quarters sampling frame. Prevalences and associations of major DSM-IV mood, anxiety and substance use disorders were examined among all major race/ethnic subgroups of the population. Twelve-month rates of most mood, anxiety and substance use disorders were generally greatest among Native Americans and lowest among Asians. For most race/ethnic subgroups, alcohol and drug dependence, but not abuse, were significantly associated with mood disorders. With few exceptions, there were no significant associations between alcohol and drug abuse and anxiety disorders. In contrast, alcohol dependence was associated with most anxiety disorders among Whites, Blacks and Asians, but not among Native Americans. The 12-month prevalence of substance use, mood, and anxiety disorders varied greatly across the five major race/ethnic subgroups of the population. Twelve-month co-occurrence of substance use disorders and mood and anxiety disorders was pervasive among all race/ethnic subgroups. Future research is also needed to understand race/ethnic differentials in prevalence and co-occurrence of these disorders with a particular focus on factors that may give rise to them. JF - Psychological medicine AU - Smith, Sharon M AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Goldstein, Rise AU - Huang, Boji AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 987 EP - 998 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Hispanic Americans KW - Humans KW - European Continental Ancestry Group KW - National Institutes of Health (U.S.) KW - Adult KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - African Continental Ancestry Group KW - Male KW - Comorbidity KW - Prevalence KW - Alcoholism -- epidemiology KW - Ethnic Groups KW - Continental Population Groups KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68046980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Race%2Fethnic+differences+in+the+prevalence+and+co-occurrence+of+substance+use+disorders+and+independent+mood+and+anxiety+disorders%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Smith%2C+Sharon+M%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise%3BHuang%2C+Boji%3BGrant%2C+Bridget+F&rft.aulast=Smith&rft.aufirst=Sharon&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Psychol Med. 2008 Apr;38(4):606 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward an alcohol use disorder continuum using item response theory: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68044782; 16563205 AB - Item response theory (IRT) was used to determine whether the DSM-IV diagnostic criteria for alcohol abuse and dependence are arrayed along a continuum of severity. Data came from a large nationally representative sample of the US population, 18 years and older. A two-parameter logistic IRT model was used to determine the severity and discrimination of each DSM-IV criterion. Differential criterion functioning (DCF) was also assessed across subgroups of the population defined by sex, age and race-ethnicity. All DSM-IV alcohol abuse and dependence criteria, except alcohol-related legal problems, formed a continuum of alcohol use disorder severity. Abuse and dependence criteria did not consistently tap the mildest or more severe end of the continuum respectively, and several criteria were identified as potentially redundant. The drinking in larger amounts or for longer than intended dependence criterion had the greatest discrimination and lowest severity than any other criterion. Although several criteria were found to function differentially between subgroups defined in terms of sex and age, there was evidence that the generalizability and validity of the criterion forming the continuum remained intact at the test score level. DSM-IV diagnostic criteria for alcohol abuse and dependence form a continuum of severity, calling into question the abuse-dependence distinction in the DSM-IV and the interpretation of abuse as a milder disorder than dependence. The criteria tapped the more severe end of the alcohol use disorder continuum, highlighting the need to identify other criteria capturing the mild to intermediate range of the severity. The drinking larger amounts or longer than intended dependence criterion may be a bridging criterion between drinking patterns that incur risk of alcohol use disorder at the milder end of the continuum, with tolerance, withdrawal, impaired control and serious social and occupational dysfunction at the more severe end of the alcohol use disorder continuum. Future IRT and other dimensional analyses hold great promise in informing revisions to categorical classifications and constructing new dimensional classifications of alcohol use disorders based on the DSM and the ICD. JF - Psychological medicine AU - Saha, Tulshi D AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 931 EP - 941 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Diagnosis, Differential KW - Ethnic Groups KW - Humans KW - National Institutes of Health (U.S.) KW - Adult KW - Disease Progression KW - Interviews as Topic KW - Models, Statistical KW - Alcohol Drinking -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68044782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Toward+an+alcohol+use+disorder+continuum+using+item+response+theory%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Saha%2C+Tulshi+D%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of deaeration methods on dissolution testing in aqueous media: a study using a total dissolved gas pressure meter. AN - 68026292; 16732563 AB - Dissolution testing is a critical method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test method temperature, typically 37 degrees C. JF - Journal of pharmaceutical sciences AU - Gao, Zongming AU - Moore, Terry W AU - Doub, William H AU - Westenberger, B J AU - Buhse, Lucinda F AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101, USA. gaoz@cder.fda.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1606 EP - 1613 VL - 95 IS - 7 SN - 0022-3549, 0022-3549 KW - Gases KW - 0 KW - Water KW - 059QF0KO0R KW - Oxygen KW - S88TT14065 KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Solubility KW - Water -- chemistry KW - Temperature KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation KW - Prednisone -- chemistry KW - Gases -- analysis KW - Chemistry, Pharmaceutical -- instrumentation KW - Oxygen -- analysis KW - Chemistry, Pharmaceutical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68026292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Effects+of+deaeration+methods+on+dissolution+testing+in+aqueous+media%3A+a+study+using+a+total+dissolved+gas+pressure+meter.&rft.au=Gao%2C+Zongming%3BMoore%2C+Terry+W%3BDoub%2C+William+H%3BWestenberger%2C+B+J%3BBuhse%2C+Lucinda+F&rft.aulast=Gao&rft.aufirst=Zongming&rft.date=2006-07-01&rft.volume=95&rft.issue=7&rft.spage=1606&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mothers' Work and Child Care AN - 61682227; 200724020 AB - In "Mothers' Work and Child Care': Julia B. Isaacs, director of the Division of Data and Technical Analysis of the Department of Health and Human Services (HHS) Office of Planning, She describes the strengths and weakness of the child care data in the main national surveys. Isaacs also examines the main data sources that HHS uses to measure the availability and quality of child care for low-income families: the Current Population Survey (CPS); the Survey of Income and Program Participation (SIPP); the National Household Education Survey (NHES); the National Survey of America's Families (NSAF); state administrative data collected by the federal government that include aggregate numbers of children receiving subsidies as well as some of the characteristics of those subsidies, such as type of provider and age of child, and state studies of those who have left the welfare rolls (leaver studies). Adapted from the source document. JF - Gender Issues AU - Isaacs, Julia B AD - Office of the Assistant Secretary for Planning and Evaluation (ASPE), U.S. Department of Health and Human Services Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 11 EP - 20 PB - Transaction Periodicals Consortium, Piscataway NJ VL - 23 IS - 3 SN - 1098-092X, 1098-092X KW - Low Income Groups KW - Mothers KW - United States of America KW - Surveys KW - Children KW - Data Quality KW - Child Care Services KW - Social Welfare KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gender+Issues&rft.atitle=Mothers%27+Work+and+Child+Care&rft.au=Isaacs%2C+Julia+B&rft.aulast=Isaacs&rft.aufirst=Julia&rft.date=2006-07-01&rft.volume=23&rft.issue=3&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Gender+Issues&rft.issn=1098092X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-03 N1 - Number of references - 8 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child Care Services; Data Quality; Social Welfare; Mothers; Children; Low Income Groups; Surveys; United States of America ER - TY - JOUR T1 - Commentary on eyler and jeste: practical issues in consent capacity and mental disorders AN - 57250110; 200816580 AB - Comments on the theoretically informed suggestions offered by Lisa T. Eyler & Dilip V. Jeste (2006) for improving the informed consent process & enhancing the ability of persons with reduced mental capacity to provide informed consent. More practical matters deserving empirical consideration are addressed, including developing simpler & more effective ways of assessing consent capacity, understanding the motivations & desired outcomes of the mentally impaired for participating in research, & diagnostic factors that can make decision making about consent more difficult. References. K. Hyatt Stewart [Copyright 2006 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Shore, David AU - Shell, Pamela Hayes AU - Wishnoff, Christine Moretto AD - National Institute of Mental Health (NIMH), Bethesda, MD (a component of the NIH and the US Department of Health and Human Services HHS dshore@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 569 EP - 572 PB - John Wiley & Sons, Chichester UK VL - 24 IS - 4 SN - 0735-3936, 0735-3936 KW - Assessment KW - Comments KW - Informed consent KW - Capacity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Commentary+on+eyler+and+jeste%3A+practical+issues+in+consent+capacity+and+mental+disorders&rft.au=Shore%2C+David%3BShell%2C+Pamela+Hayes%3BWishnoff%2C+Christine+Moretto&rft.aulast=Shore&rft.aufirst=David&rft.date=2006-07-01&rft.volume=24&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.690 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Capacity; Informed consent; Comments; Assessment DO - http://dx.doi.org/10.1002/bsl.690 ER - TY - JOUR T1 - Smoking and Bladder Cancer in Spain: Effects of Tobacco Type, Timing, Environmental Tobacco Smoke, and Gender AN - 20855579; 6994536 AB - We examined the effects of dose, type of tobacco, cessation, inhalation, and environmental tobacco smoke exposure on bladder cancer risk among 1,219 patients with newly diagnosed bladder cancer and 1,271 controls recruited from 18 hospitals in Spain. We used unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the association between bladder cancer risk and various characteristics of cigarette smoking. Current smokers (men: OR, 7.4; 95% CI, 5.3-10.4; women: OR, 5.1; 95% CI, 1.6-16.4) and former smokers (men: OR, 3.8; 95% CI, 2.8-5.3; women: OR, 1.8; 95% CI, 0.5-7.2) had significantly increased risks of bladder cancer compared with nonsmokers. We observed a significant positive trend in risk with increasing duration and amount smoked. After adjustment for duration, risk was only 40% higher in smokers of black tobacco than that in smokers of blond tobacco (OR, 1.4; 95% CI, 0.98-2.0). Compared with risk in current smokers, a significant inverse trend in risk with increasing time since quitting smoking blond tobacco was observed ( greater than or equal to 20 years cessation: OR, 0.2; 95% CI, 0.1-0.9). No trend in risk with cessation of smoking black tobacco was apparent. Compared with men who inhaled into the mouth, risk increased for men who inhaled into the throat (OR, 1.7; 95% CI, 1.1-2.6) and chest (OR, 1.5; 95% CI, 1.1-2.1). Cumulative occupational exposure to environmental tobacco smoke seemed to confer increased risk among female nonsmokers but not among male nonsmokers. After eliminating the effect of cigarette smoking on bladder cancer risk in our study population, the male-to-female incidence ratio decreased from 8.2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens. (Cancer Epidemiol Biomarkers Prev 2006; 15(7):1348-54) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Samanic, Claudine AU - Kogevinas, Manolis AU - Dosemeci, Mustafa AU - Malats, Nuria AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Sala, Maria AU - Lloreta, Josep AU - Tardon, Adonina AU - Rothman, Nathaniel AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1348 EP - 1354 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 7 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts KW - Bioindicators KW - Inhalation KW - Spain KW - Carcinogens KW - Cancer KW - urinary bladder KW - Passive smoking KW - Cigarette smoking KW - Gender KW - Tobacco KW - prevention KW - Occupational exposure KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Smoking+and+Bladder+Cancer+in+Spain%3A+Effects+of+Tobacco+Type%2C+Timing%2C+Environmental+Tobacco+Smoke%2C+and+Gender&rft.au=Samanic%2C+Claudine%3BKogevinas%2C+Manolis%3BDosemeci%2C+Mustafa%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BSala%2C+Maria%3BLloreta%2C+Josep%3BTardon%2C+Adonina%3BRothman%2C+Nathaniel%3BSilverman%2C+Debra+T&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1348&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Bioindicators; urinary bladder; Passive smoking; Gender; Cigarette smoking; prevention; Tobacco; Carcinogens; Occupational exposure; Cancer; Hospitals; Spain ER - TY - JOUR T1 - Food-processing enzymes from recombinant microorganisms-a review AN - 20721816; 6999824 AB - Enzymes are commonly used in food processing and in the production of food ingredients. Enzymes traditionally isolated from culturable microorganisms, plants, and mammalian tissues are often not well-adapted to the conditions used in modern food production methods. The use of recombinant DNA technology has made it possible to manufacture novel enzymes suitable for specific food-processing conditions. Such enzymes may be discovered by screening microorganisms sampled from diverse environments or developed by modification of known enzymes using modern methods of protein engineering or molecular evolution. As a result, several important food-processing enzymes such as amylases and lipases with properties tailored to particular food applications have become available. Another important achievement is improvement of microbial production strains. For example, several microbial strains recently developed for enzyme production have been engineered to increase enzyme yield by deleting native genes encoding extracellular proteases. Moreover, certain fungal production strains have been modified to reduce or eliminate their potential for production of toxic secondary metabolites. In this article, we discuss the safety of microorganisms used as hosts for enzyme-encoding genes, the construction of recombinant production strains, and methods of improving enzyme properties. We also briefly describe the manufacture and safety assessment of enzyme preparations and summarize options for submitting information on enzyme preparations to the US Food and Drug Administration. JF - Regulatory Toxicology and Pharmacology AU - Olempska-Beer, Z S AU - Merker, R I AU - Ditto, MD AU - DiNovi, MJ AD - Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA, zofia.olempskabeer@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 144 EP - 158 PB - Elsevier Inc. VL - 45 IS - 2 SN - 0273-2300, 0273-2300 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts KW - Food processing KW - Triacylglycerol lipase KW - molecular evolution KW - Protein engineering KW - Reviews KW - Microorganisms KW - DNA KW - Enzymes KW - Secondary metabolites KW - Proteinase KW - Food plants KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - A 01330:Food Microbiology KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Food-processing+enzymes+from+recombinant+microorganisms-a+review&rft.au=Olempska-Beer%2C+Z+S%3BMerker%2C+R+I%3BDitto%2C+MD%3BDiNovi%2C+MJ&rft.aulast=Olempska-Beer&rft.aufirst=Z&rft.date=2006-07-01&rft.volume=45&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2006.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Triacylglycerol lipase; molecular evolution; Protein engineering; Reviews; DNA; Microorganisms; Secondary metabolites; Enzymes; Proteinase; Food plants DO - http://dx.doi.org/10.1016/j.yrtph.2006.05.001 ER - TY - JOUR T1 - Populations at Risk Across the Lifespan: Case Reports: Correlates of Public Health Workforce Acceptance of Smallpox Immunization in Virginia AN - 20720133; 6962394 AB - By October 24, 2003, 38,577 of 500,000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Design: Cross-sectional survey, conducted in May 2004. Sample: We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Results: Among nonvaccinees (n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees (n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6-85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1-22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6-81.1). Conclusion: Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed. JF - Public Health Nursing AU - Bryant-Genevier, Marthe AU - Sommer, Sandra AU - McMahon, Ann AU - Ball, Robert AU - Braun, MMiles AD - Marthe Bryant-Genevier, Vaccine Safety Branch, Suite 268 S, HFM-222, CBER-OBE-DE-Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, marthe.bryant-genevier@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 339 EP - 346 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 23 IS - 4 SN - 0737-1209, 0737-1209 KW - Virology & AIDS Abstracts; Risk Abstracts KW - vaccines KW - Motivation KW - bioterrorism KW - Life span KW - Disasters KW - USA, Virginia KW - Vaccination KW - Public health KW - immunization KW - Smallpox KW - safety engineering KW - Health care KW - Case reports KW - Perception KW - Personnel KW - Nursing KW - Vigilance KW - Vaccines KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nursing&rft.atitle=Populations+at+Risk+Across+the+Lifespan%3A+Case+Reports%3A+Correlates+of+Public+Health+Workforce+Acceptance+of+Smallpox+Immunization+in+Virginia&rft.au=Bryant-Genevier%2C+Marthe%3BSommer%2C+Sandra%3BMcMahon%2C+Ann%3BBall%2C+Robert%3BBraun%2C+MMiles&rft.aulast=Bryant-Genevier&rft.aufirst=Marthe&rft.date=2006-07-01&rft.volume=23&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nursing&rft.issn=07371209&rft_id=info:doi/10.1111%2Fj.1525-1446.2006.00570.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 3; references, 9. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smallpox; Motivation; Case reports; Personnel; Perception; bioterrorism; Nursing; Life span; Vigilance; Vaccines; Vaccination; Public health; immunization; vaccines; safety engineering; Health care; Disasters; USA, Virginia DO - http://dx.doi.org/10.1111/j.1525-1446.2006.00570.x ER - TY - JOUR T1 - Absorption, Distribution, and Excretion of Ammonium Perfluorooctanoate (APFO) After Oral Administration to Various Species AN - 20336794; 7692132 AB - Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h (168 h in the rabbit). Substantial sex and species differences in the excretion and disposition of 14C-radioactivity derived from 14C-labeled APFO were observed in this study. The female rat and the male hamster excreted more than 99% of the original 14C activity by 120 h after dosing; conversely, the male rat and the female hamster excreted only 39% and 60% of the original 14C activity, respectively, by 120 h postdosing. The male and female rabbits excreted the 14C activity as rapidly and completely as the female rat and the male hamster, whereas male and female mice excreted only 21% of the original 14C activity by 120 h postdosing. The rapid excretors (female rat, male hamster, and male and female rabbits) contained negligible amounts of 14C in organs and tissues at sacrifice. The slow excretors exhibited the highest 14C concentrations in the blood and liver followed by the kidneys, lungs, and skin. JF - Drug and Chemical Toxicology AU - Hundley, S G AU - Sarrif, A M AU - Kennedy Jr, G L AD - Food and Drug Administration, Center for Drug and Evaluation and Research, Rockville, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 137 EP - 145 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 29 IS - 2 SN - 0148-0545, 0148-0545 KW - Toxicology Abstracts KW - Blood KW - Ammonium KW - Skin KW - Lung KW - Kidney KW - Liver KW - Oral administration KW - Excretion KW - Disposition KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20336794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Chemical+Toxicology&rft.atitle=Absorption%2C+Distribution%2C+and+Excretion+of+Ammonium+Perfluorooctanoate+%28APFO%29+After+Oral+Administration+to+Various+Species&rft.au=Hundley%2C+S+G%3BSarrif%2C+A+M%3BKennedy+Jr%2C+G+L&rft.aulast=Hundley&rft.aufirst=S&rft.date=2006-07-01&rft.volume=29&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Drug+and+Chemical+Toxicology&rft.issn=01480545&rft_id=info:doi/10.1080%2F01480540600561361 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ammonium; Blood; Skin; Lung; Oral administration; Liver; Kidney; Disposition; Excretion DO - http://dx.doi.org/10.1080/01480540600561361 ER - TY - JOUR T1 - Human NK cells can lyse porcine endothelial cells independent of their expression of Gal alpha (1,3)-Gal and killing is enhanced by activation of either effector or target cells AN - 20234438; 6963277 AB - Background:Xenotransplantation of pig organs may provide an approach to alleviate the severe shortage of human organs. Natural antibodies against Gal alpha (1,3)-Gal ( alpha Gal) epitopes cause hyperacute rejection of pig organs in primates. However, evidence for the role of alpha Gal in the natural killer (NK) cell-mediated xenoresponse has been contradictory. Methods:We investigated the recognition of alpha Gal by human NK cells using endo- beta -galactosidase C, an enzyme that cleaves alpha Gal, and endothelial cells (EC) from alpha 1,3-galactosyltransferase null pigs that do not synthesize alpha Gal. Endo- beta -galactosidase C treatment variably reduced the susceptibility of porcine EC to lysis by fresh human NK cells. Results:Removal of alpha Gal from porcine EC using endo- beta -galactosidase C, produced variable results, i.e. cytotoxicity was decreased in half of the human NK cell donors tested. The two EC strains from alpha Gal-/- pigs were marginally, and not significantly, less susceptible to lysis by naive human NK cells compared with alpha Gal-expressing cells obtained from animals from the same herd, but these differences were not statistically significant (P > 0.10). Treatment of porcine EC with recombinant human tumor necrosis factor (TNF)- alpha , which is known to activate porcine EC, enhanced the susceptibility of all target cells to lysis by fresh human NK cells. Surface expression of MHC or adhesion molecules on alpha Gal-/- cells, compared with wild type cells, showed no consistent difference in either MHC or adhesion molecules CD106 (VCAM-1), CD31 (PECAM) or CD62E (E-selectin), either with or without TNF- alpha stimulation, that could explain the differential susceptibility to lysis. Strikingly, all alpha Gal-/- and wild type EC exhibited similar susceptibility to human NK cells that had been cultured for 5 days with or without interleukin-2. Conclusions:These findings demonstrate that human NK cells can kill porcine targets in the absence of alpha Gal, and donor variability plays a major role in whether alpha Gal has a role in determining susceptibility of porcine EC to lysis. Moreover, susceptibility to lysis of alpha Gal null EC is enhanced to the level of wild type EC by activation of either effector or target cells. Elimination of alpha Gal alone from source pigs will be insufficient to circumvent the NK cell mediated destruction of porcine EC. JF - Xenotransplantation AU - Horvath-Arcidiacono, Judith A AU - Porter, Cynthia M AU - Bloom, Eda T AD - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA, bloom@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 318 EP - 327 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 13 IS - 4 SN - 0908-665X, 0908-665X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 2 KW - Statistical analysis KW - Natural killer cells KW - Enzymes KW - Major histocompatibility complex KW - Primates KW - Effector cells KW - Endothelial cells KW - vascular cell adhesion molecule 1 KW - Cytotoxicity KW - Antibodies KW - Xenografts KW - Tumor necrosis factor- alpha KW - Epitopes KW - E-selectin KW - Cell adhesion molecules KW - W 30925:Genetic Engineering KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Human+NK+cells+can+lyse+porcine+endothelial+cells+independent+of+their+expression+of+Gal+alpha+%281%2C3%29-Gal+and+killing+is+enhanced+by+activation+of+either+effector+or+target+cells&rft.au=Horvath-Arcidiacono%2C+Judith+A%3BPorter%2C+Cynthia+M%3BBloom%2C+Eda+T&rft.aulast=Horvath-Arcidiacono&rft.aufirst=Judith&rft.date=2006-07-01&rft.volume=13&rft.issue=4&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2006.00316.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 6. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 2; Natural killer cells; Statistical analysis; Major histocompatibility complex; Enzymes; Effector cells; Endothelial cells; vascular cell adhesion molecule 1; Antibodies; Cytotoxicity; Tumor necrosis factor- alpha; Xenografts; Cell adhesion molecules; E-selectin; Epitopes; Primates DO - http://dx.doi.org/10.1111/j.1399-3089.2006.00316.x ER - TY - JOUR T1 - Contribution of interferon- beta to the immune activation induced by double-stranded DNA AN - 20193763; 6959835 AB - Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial-viral factors. Current findings indicate that interferon- beta (IFN- beta ) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN- beta ) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA. JF - Immunology AU - Shirota, Hidekazu AU - Ishii, Ken J AU - Takakuwa, Hiroki AU - Klinman, Dennis M AD - Section of Retroviral Immunology, klinman@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 302 EP - 310 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 118 IS - 3 SN - 0019-2805, 0019-2805 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Macrophages KW - beta -Interferon KW - Chemokines KW - MyD88 protein KW - Infection KW - DNA-dependent protein kinase KW - Cell activation KW - Costimulator KW - Dendritic cells KW - Cytoplasm KW - Cytokines KW - Immune response KW - Antigen-presenting cells KW - V 22320:Replication KW - N 14845:Miscellaneous KW - F 06960:Molecular Immunology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Contribution+of+interferon-+beta+to+the+immune+activation+induced+by+double-stranded+DNA&rft.au=Shirota%2C+Hidekazu%3BIshii%2C+Ken+J%3BTakakuwa%2C+Hiroki%3BKlinman%2C+Dennis+M&rft.aulast=Shirota&rft.aufirst=Hidekazu&rft.date=2006-07-01&rft.volume=118&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/10.1111%2Fj.1365-2567.2006.02367.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 7; tables, 1; references, 35. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Macrophages; Chemokines; MyD88 protein; Infection; DNA-dependent protein kinase; Cell activation; Dendritic cells; Costimulator; Cytoplasm; Cytokines; Antigen-presenting cells; Immune response DO - http://dx.doi.org/10.1111/j.1365-2567.2006.02367.x ER - TY - JOUR T1 - Molecular characterization of cytochrome P450 genes in the polycyclic aromatic hydrocarbon degrading Mycobacterium vanbaalenii PYR-1 AN - 20001294; 7240895 AB - Mycobacterium vanbaalenii PYR-1 has the ability to degrade low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs). In addition to dioxygenases, cytochrome P450 monooxygenases have been implicated in PAH degradation. Three cytochrome P450 genes, cyp151 (pipA), cyp150, and cyp51, were detected and amplified by polymerase chain reaction from M. vanbaalenii PYR-1. The complete sequence of these genes was determined. The translated putative proteins were greater than or equal to 80% identical to other GenBank-listed mycobacterial CYP151, CYP150, and CYP51. Genes pipA and cyp150 were cloned, and the proteins partially expressed in Escherchia coli as soluble heme-containing cytochrome P450s that exhibited a characteristic peak at 450 nm in reduced carbon monoxide difference spectra. Monooxygenation metabolites of pyrene, dibenzothiophene, and 7-methylbenz[ alpha ]anthracene were detected in whole cell biotransformations, with E. coli expressing pipA or cyp150 when analyzed by gas chromatography/mass spectrometry. The cytochrome P450 inhibitor metyrapone strongly inhibited the S-oxidation of dibenzothiophene. Thirteen other Mycobacterium strains were screened for the presence of pipA, cyp150, and cyp51 genes, as well as the initial PAH dioxygenase (nidA and nidB). The results indicated that many of the Mycobacterium spp. surveyed contain both monooxygenases and dioxygenases to degrade PAHs. Our results provide further evidence for the diverse enzymatic capability of Mycobacterium spp. to metabolize polycylic aromatic hydrocarbons. JF - Applied Microbiology and Biotechnology AU - Brezna, Barbara AU - Kweon, Ohgew AU - Stingley, Robin L AU - Freeman, James P AU - Khan, Ashraf A AU - Polek, Bystrik AU - Jones, Richard C AU - Cerniglia, Carl E AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, ccerniglia@nctr.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 522 EP - 532 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 71 IS - 4 SN - 0175-7598, 0175-7598 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Pipa KW - Mycobacterium vanbaalenii KW - Polycyclic aromatic hydrocarbons KW - Cytochrome P450 monooxygenase KW - Biodegradation KW - monooxygenase KW - Mycobacterium KW - Thioxanthene KW - biotransformation KW - Metabolites KW - Pyrene KW - Mass spectroscopy KW - Carbon monoxide KW - Gas chromatography KW - Escherichia coli KW - Aromatic hydrocarbons KW - Polymerase chain reaction KW - Cytochrome P450 KW - Dioxygenase KW - Dibenzothiophene KW - J 02310:Genetics & Taxonomy KW - W 30950:Waste Treatment & Pollution Clean-up KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Molecular+characterization+of+cytochrome+P450+genes+in+the+polycyclic+aromatic+hydrocarbon+degrading+Mycobacterium+vanbaalenii+PYR-1&rft.au=Brezna%2C+Barbara%3BKweon%2C+Ohgew%3BStingley%2C+Robin+L%3BFreeman%2C+James+P%3BKhan%2C+Ashraf+A%3BPolek%2C+Bystrik%3BJones%2C+Richard+C%3BCerniglia%2C+Carl+E&rft.aulast=Brezna&rft.aufirst=Barbara&rft.date=2006-07-01&rft.volume=71&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-005-0190-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytochrome P450 monooxygenase; Polycyclic aromatic hydrocarbons; monooxygenase; Biodegradation; Thioxanthene; biotransformation; Metabolites; Pyrene; Mass spectroscopy; Carbon monoxide; Gas chromatography; Polymerase chain reaction; Aromatic hydrocarbons; Cytochrome P450; Dioxygenase; Dibenzothiophene; Pipa; Mycobacterium vanbaalenii; Mycobacterium; Escherichia coli DO - http://dx.doi.org/10.1007/s00253-005-0190-8 ER - TY - JOUR T1 - The Defined Combination of Growth Factors Controls Generation of Long-Term-Replicating Islet Progenitor-Like Cells from Cultures of Adult Mouse Pancreas AN - 19975784; 6999344 AB - Application of pancreatic islet transplantation to treatment of diabetes is severely hampered by the inadequate islet supply. This problem could in principle be overcome by generating islet cells from adult pancreas in vitro. Although it is possible to obtain replicating cells from cultures of adult pancreas, these cells, when significantly expanded in vitro, progressively lose pancreatic-specific gene expression, including that of a "master" homeobox transcription factor Pdx1. Here we show for the first time that long-term proliferating islet progenitor-like cells (IPLCs) stably expressing high levels of Pdx1 and other genes that control early pancreatic development can be derived from cultures of adult mouse pancreas under serum-free defined culture conditions. Moreover, we show that cells derived thus can be maintained in continuous culture for at least 6 months without any substantial loss of early pancreatic phenotype. Upon growth factor withdrawal, the IPLCs organize into cell clusters and undergo endocrine differentiation of various degrees in a line-dependent manner. We propose that our experimental strategy will provide a framework for developing efficient approaches for ex vivo expansion of islet cell mass. JF - Stem Cells AU - Ta, Malancha AU - Choi, Yong AU - Atouf, Fouad AU - Park, Cheol Hong AU - Lumelsky, Nadya AD - Islet and Autoimmunity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1738 EP - 1749 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Transplantation KW - Pancreas KW - Homeobox KW - Islet cells KW - Islets of Langerhans KW - Cell culture KW - Diabetes mellitus KW - Gene expression KW - Differentiation KW - Stem cells KW - Continuous culture KW - Transcription factors KW - Allografts KW - Growth factors KW - Pancreatic islet transplantation KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Defined+Combination+of+Growth+Factors+Controls+Generation+of+Long-Term-Replicating+Islet+Progenitor-Like+Cells+from+Cultures+of+Adult+Mouse+Pancreas&rft.au=Ta%2C+Malancha%3BChoi%2C+Yong%3BAtouf%2C+Fouad%3BPark%2C+Cheol+Hong%3BLumelsky%2C+Nadya&rft.aulast=Ta&rft.aufirst=Malancha&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1738&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transplantation; Pancreas; Cell culture; Islets of Langerhans; Islet cells; Homeobox; Gene expression; Diabetes mellitus; Differentiation; Stem cells; Continuous culture; Transcription factors; Allografts; Pancreatic islet transplantation; Growth factors ER - TY - JOUR T1 - Identification and Functional Analysis of Candidate Genes Regulating Mesenchymal Stem Cell Self-Renewal and Multipotency AN - 19959893; 6999341 AB - Adult human mesenchymal stem cells (hMSCs) possess multilineage differentiation potential, and differentiated hMSCs have recently been shown to have the ability to transdifferentiate into other lineages. However, the molecular signature of hMSCs is not well-known, and the mechanisms regulating their self-renewal, differentiation, and transdifferentiation are not completely understood. In this study, we demonstrate that fully differentiated hMSCs could dedifferentiate, a likely critical step for transdifferentiation. By comparing the global gene expression profiles of undifferentiated, differentiated, and dedifferentiation cells in three mesenchymal lineages (osteogenesis, chondrogenesis, and adipogenesis), we identified a number of "stemness" and "differentiation" genes that might be essential to maintain adult stem cell multipotency as well as to drive lineage-specific commitment. These genes include those that encode cell surface molecules, as well as components of signaling pathways. These genes may be valuable for developing methods to isolate, enrich, and purify homogeneous population of hMSCs and/or maintain and propagate hMSCs as well as guide or regulate their differentiation for gene and cell-based therapy. Using small interfering RNA gene inactivation, we demonstrate that five genes (actin filament-associated protein, frizzled 7, dickkopf 3, protein tyrosine phosphatase receptor F, and RAB3B) promote cell survival without altering cell proliferation, as well as exhibiting different effects on the commitment of hMSCs into multiple mesenchymal lineages. JF - Stem Cells AU - Song, Lin AU - Webb, Nicole E AU - Song, Yingjie AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1707 EP - 1718 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Cell surface KW - Frizzled protein KW - Protein-tyrosine-phosphatase KW - Gene expression KW - Stem cells KW - siRNA KW - Actin KW - Cell proliferation KW - Mesenchyme KW - adipogenesis KW - Chondrogenesis KW - Osteogenesis KW - Signal transduction KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Identification+and+Functional+Analysis+of+Candidate+Genes+Regulating+Mesenchymal+Stem+Cell+Self-Renewal+and+Multipotency&rft.au=Song%2C+Lin%3BWebb%2C+Nicole+E%3BSong%2C+Yingjie%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1707&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Cell surface; Frizzled protein; Protein-tyrosine-phosphatase; Gene expression; Stem cells; siRNA; Actin; adipogenesis; Mesenchyme; Cell proliferation; Signal transduction; Osteogenesis; Chondrogenesis ER - TY - JOUR T1 - High Level Expression and Characterization of the Cyclophilin B Gene from the Anaerobic Fungus Orpinomyces sp. Strain PC-2 AN - 19794516; 7659566 AB - Cyclophilins are an evolutionarily conserved family of peptidyl-prolyl cis-trans isomerases (PPIases). A cyclophilin B (cypB) gene from the anaerobic fungus Orpinomyces sp. strain PC-2 was cloned and overexpressed in Escherichia coli. It was expressed as an amino-terminal 6 x His-tagged recombinant protein to facilitate purification. Highly purified protein (26.5 kDa) was isolated by two chromatographic steps involving affinity and gel filtration for biochemical studies of the enzyme. The recombinant CypB displayed PPIase activity with a kcat/Km of 8.9 x 106 M-1 s-1 at 10 degree C and pH 7.8. It was inhibited by cyclosporin A (CsA) with an IC50 of 23.5 nM, similar to those of the native protein and other cyclophilin B enzymes from animals. Genomic DNA analysis of cypB revealed that it was present as a single copy in Orpinomyces PC-2 and contained two introns, indicating it has a eukaryotic origin. It is one of the most heavily interrupted genes with intron sequences found in anaerobic fungi. The three-dimensional model of Orpinomyces PC-2 CypB was predicted with a homology modeling approach using the Swiss-Model Protein Modeling Server and three dimensional structure of human CypB as a template. The overall architecture of the CypB molecule is very similar to that of human CypB. JF - Protein & Peptide Letters AU - Chen, Huizhong AU - Li, Xin-Liang AU - Xu, Haiyan AU - Ljungdahl, Lars G AU - Cerniglia, Carl E AD - Division of Microbiology,National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd.,Jefferson, AR 72079, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 727 EP - 732 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 13 IS - 7 SN - 0929-8665, 0929-8665 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Cyclophilin B KW - PPIase KW - Orpinomyces sp. strain PC-2 KW - characterization KW - introns KW - gene analysis KW - Fungi KW - Enzymes KW - protein purification KW - Models KW - Filtration KW - Orpinomyces KW - Homology KW - Peptidylprolyl isomerase KW - Escherichia coli KW - DNA KW - Introns KW - genomics KW - Cyclosporin A KW - pH effects KW - Evolution KW - J 02410:Animal Diseases KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+%26+Peptide+Letters&rft.atitle=High+Level+Expression+and+Characterization+of+the+Cyclophilin+B+Gene+from+the+Anaerobic+Fungus+Orpinomyces+sp.+Strain+PC-2&rft.au=Chen%2C+Huizhong%3BLi%2C+Xin-Liang%3BXu%2C+Haiyan%3BLjungdahl%2C+Lars+G%3BCerniglia%2C+Carl+E&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2006-07-01&rft.volume=13&rft.issue=7&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Protein+%26+Peptide+Letters&rft.issn=09298665&rft_id=info:doi/10.2174%2F092986606777790511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fungi; Enzymes; protein purification; Models; Filtration; Peptidylprolyl isomerase; Homology; Introns; DNA; Cyclosporin A; genomics; pH effects; Evolution; Orpinomyces; Escherichia coli DO - http://dx.doi.org/10.2174/092986606777790511 ER - TY - JOUR T1 - Diffusion of limonene in polyethylene AN - 19750134; 8681659 AB - Diffusion coefficients of limonene in various linear low-density polyethylene (LLDPE) and low-density polyethylene (LDPE) resins have been determined from sorption data using a thermogravimetric methodology. From these data, one can determine whether polymer synthesis parameters such as the choice of catalytic process or co-monomer result in substantial differences in how much food packaging additives might migrate to food. For example, LLDPE is currently manufactured using either one of two distinct catalytic processes: Ziegler-Natta (ZN) and metallocene, a single-site catalyst. ZN catalysis is a heterogeneous process that has dominated polyolefin synthesis over the last half-century. It involves a transition metal compound containing a metal-carbon bond that can handle repeated insertion of olefin units. In contrast, metallocene catalysis has fewer than 20 years of history, but has generated much interest due to its ability to produce highly stereospecific polymers at a very high yield. In addition to high stereospecificity, metallocene-catalysed polymers are significantly lower in polydispersity than traditional ZN counterparts. Absorption and desorption testing of heat-pressed films made from LLDPE and LDPE resins of varying processing parameters indicates that diffusion coefficients of limonene in these resins do not change substantially. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Limm, W AU - Begley, T H AU - Lickly, T AU - Hentges, S G AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (HFS-245), College Park, MD 20740, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 738 EP - 746 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 23 IS - 7 SN - 0265-203X, 0265-203X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Absorption KW - Diffusion KW - Packaging KW - Sorption KW - Metals KW - Resins KW - Risk assessment KW - Food additives KW - Catalysts KW - Desorption KW - Polymers KW - Additives KW - Catalysis KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19750134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Diffusion+of+limonene+in+polyethylene&rft.au=Limm%2C+W%3BBegley%2C+T+H%3BLickly%2C+T%3BHentges%2C+S+G&rft.aulast=Limm&rft.aufirst=W&rft.date=2006-07-01&rft.volume=23&rft.issue=7&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030600654408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Polymers; Diffusion; Resins; Absorption; Catalysis; Metals; Food additives; Packaging; Risk assessment; Desorption; Sorption; Additives; Historical account; Catalysts DO - http://dx.doi.org/10.1080/02652030600654408 ER - TY - JOUR T1 - Bacillus tequilensis sp. nov., isolated from a 2000-year-old Mexican shaft-tomb, is closely related to Bacillus subtilis AN - 19555088; 7271292 AB - A Gram-positive, spore-forming bacillus was isolated from a sample taken from an approximately 2000-year-old shaft-tomb located in the Mexican state of Jalisco, near the city of Tequila. Tentative identification using conventional biochemical analysis consistently identified the isolate as Bacillus subtilis. DNA isolated from the tomb isolate, strain 10b super(T), and closely related species was used to amplify a Bacillus-specific portion of the highly conserved 16S rRNA gene and an internal region of the superoxide dismutase gene (sodA sub(int)). Trees derived from maximum-likelihood methods applied to the sodA sub(int) sequences yielded non-zero branch lengths between strain 10b super(T) and its closest relative, whereas a comparison of a Bacillus-specific 546 bp amplicon of the 16S rRNA gene demonstrated 99 % similarity with B. subtilis. Although the 16S rRNA gene sequences of strain 10b super(T) and B. subtilis were 99 % similar, PFGE of NotI-digested DNA of strain 10b super(T) revealed a restriction profile that was considerably different from those of B. subtilis and other closely related species. Whereas qualitative differences in whole-cell fatty acids were not observed, significant quantitative differences were found to exist between strain 10b super(T) and each of the other closely related Bacillus species examined. In addition, DNA-DNA hybridization studies demonstrated that strain 10b super(T) had a relatedness value of less than 70 % with B. subtilis and other closely related species. Evidence from the sodA sub(int) sequences, whole-cell fatty acid profiles and PFGE analysis, together with results from DNA-DNA hybridization studies, justify the classification of strain 10b super(T) as representing a distinct species, for which the name Bacillus tequilensis sp. nov. is proposed. The type strain is 10b super(T) (=ATCC BAA-819 super(T)=NCTC 13306 super(T)). The GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequence of strain 10b super(T) is AY197613 and those for the sodA sub(int) gene sequences of strain 10b super(T), Bacillus amyloliquefaciens ATCC 23842, Bacillus atrophaeus NRRL NRS-213 super(T), Paenibacillus lentimorbus ATCC 14707 super(T), Bacillus mojavensis NRRL B-14698 super(T) and Bacillus vallismortis NRRL B-14890 super(T) are AY197614-AY197619, respectively. A comparison of phenotypic characteristics of Bacillus tequilensis sp. nov. 10b super(T) and other Bacillus species is available as supplementary material in IJSEM Online. JF - International Journal of Systematic and Evolutionary Microbiology AU - Gatson, Joshua W AU - Benz, Bruce F AU - Chandrasekaran, Chitra AU - Satomi, Masataka AU - Venkateswaran, Kasthuri AU - Hart, Mark E AD - Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA, mark.hart@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1475 EP - 1484 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 56 IS - 7 SN - 1466-5026, 1466-5026 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Classification KW - Superoxide dismutase KW - Nucleotide sequence KW - Paenibacillus lentimorbus KW - Fatty acids KW - DNA KW - Biochemical analysis KW - Bacillus amyloliquefaciens KW - rRNA 16S KW - Bacillus tequilensis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19555088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.atitle=Bacillus+tequilensis+sp.+nov.%2C+isolated+from+a+2000-year-old+Mexican+shaft-tomb%2C+is+closely+related+to+Bacillus+subtilis&rft.au=Gatson%2C+Joshua+W%3BBenz%2C+Bruce+F%3BChandrasekaran%2C+Chitra%3BSatomi%2C+Masataka%3BVenkateswaran%2C+Kasthuri%3BHart%2C+Mark+E&rft.aulast=Gatson&rft.aufirst=Joshua&rft.date=2006-07-01&rft.volume=56&rft.issue=7&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.issn=14665026&rft_id=info:doi/10.1099%2Fijs.0.63946-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Classification; Superoxide dismutase; Nucleotide sequence; DNA; Fatty acids; Biochemical analysis; rRNA 16S; Bacillus subtilis; Paenibacillus lentimorbus; Bacillus amyloliquefaciens; Bacillus tequilensis DO - http://dx.doi.org/10.1099/ijs.0.63946-0 ER - TY - JOUR T1 - A Numerical and Experimental Investigation of Crystalline Silica Exposure Control During Tuck Pointing AN - 19481447; 7178798 AB - National Institute for Occupational Safety and Health researchers investigated control measures for the removal of mortar between bricks, using a grinder. This task, "tuck pointing," is associated with crystalline silica exposures many times greater than the permissible exposure limit enforced by the Occupational Safety and Health Administration. Previous studies showed that local exhaust ventilation (LEV) of the grinding wheel through a shroud was often ineffective. Tuck pointing occurs on a scaffold. For practical purposes, this limits the size and power of the LEV system. Thus, the goal of this study was to develop a recommended flow rate for exposure control. Flow induced by the rotating grinding wheel, flow induced by the mortar particle stream, and particle momentum are potential control challenges. Computational fluid dynamic (CFD) simulation of the grinder, supported by some experimental measurements, showed the relative importance of these factors through varying parameters and tracking particles. In a simulation of the shroud and grinding wheel, with the wheel inserted to a cutting depth of 0.750 inch flush into the brick wall, -0.461 cubic feet per meter (0.461 into the exhaust takeoff) was induced by the rotating wheel. The more realistic situation of the wheel in a cut in the wall 1.25 inches deep (forming a trench circumferentially 0.500 inch below the wheel edge) induced an airflow of 8.24 cfm out of the shroud exhaust. Experimental measurements taken for validation were 7.3% lower than the CFD value. The trench effect disappeared when a stream of 10- mu m particles was launched from the grinding wheel edge, as the simulations with and without the trench had nearly identical induced flow rates, 10.8 cfm and 10.9 cfm. We thus interpreted the particle stream as more important than the wheel in inducing flow. This insight was possible because of the power of CFD, compared to intuition and classical boundary layer analysis. In this situation of no forced exhaust, all particles escaped through the gap between the shroud edge and the brick wall into the worker's environment. Experiments and simulations indicated that approximately 85 cfm was required for good control of silica exposure, clearly demonstrating that the exhaust rate must accomplish much more than balancing the induced flow. The simulations showed that the exhaust must create a vacuum in the shroud sufficient to bend the particle paths into the shroud. In the simulations, stopping the particle stream through collision (effectively removing or reducing the "daylight" between the wall and shroud) greatly lessened the required flow rate. This is difficult in practice because the gaps between the shroud and the brick and between bricks create escape paths. JF - Journal of Occupational and Environmental Hygiene AU - Heitbrink, W AU - Bennett, J AD - NIOSH-DART/EPHB, 4676 Columbia Parkway, MS R5, Cincinnati, OH 45226-1998, USA, jbennett@cdc.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 366 EP - 378 VL - 3 IS - 7 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Simulation KW - Vacuum KW - Particulates KW - Computer applications KW - Streams KW - Flow rates KW - scaffolds KW - Exhausts KW - Silica KW - silica KW - Boundary layers KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19481447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Numerical+and+Experimental+Investigation+of+Crystalline+Silica+Exposure+Control+During+Tuck+Pointing&rft.au=Heitbrink%2C+W%3BBennett%2C+J&rft.aulast=Heitbrink&rft.aufirst=W&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600762057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Silica; Ventilation; Boundary layers; Vacuum; Computer applications; Streams; scaffolds; Occupational exposure; Environmental hygiene; Exhausts; silica; Simulation; Particulates; Flow rates DO - http://dx.doi.org/10.1080/15459620600762057 ER - TY - JOUR T1 - The impact of affect and frequency on lexical decision: The role of the amygdala and inferior frontal cortex AN - 19446772; 6931190 AB - The current study used event-related fMRI to examine BOLD responses associated with two factors that behaviorally determine speed of lexical decision: frequency and emotion. Thirteen healthy adults performed a visual lexical decision task, discriminating between words and orthographically and phonologically legal nonwords. The study involved a 2 (Frequency: high and low) x 3 (Emotional arousal: highly negative, mildly negative, and neutral words) design with word categories matched for number of letters and concreteness. There were significant main effects for both frequency and emotion in lexical decision reaction times but no significant interaction. Negative word lexical decisions were associated with increased activation in bilateral amygdala and middle temporal cortex as well as rostral anterior and posterior cingulate cortex. Low-frequency word lexical decisions, relative to high-frequency word lexical decisions, were associated with increased bilateral activity in inferior frontal cortex. Inferior frontal cortex activation was particularly low during lexical decision for high-frequency emotional words but significant for high- frequency neutral emotional words. We suggest that this is because the semantic representation of high-frequency emotional words may receive sufficient additional augmentation via the reciprocal activation from the amygdala such that selective augmentation by inferior frontal cortex to achieve lexical decision is unnecessary. JF - NeuroImage AU - Nakic, Marina AU - Smith, Bruce W AU - Busis, Sarah AU - Vythilingam, Meena AU - Blair, RJames R AD - Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, nakicm@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1752 EP - 1761 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Emotions KW - Arousal KW - Functional magnetic resonance imaging KW - Cortex (frontal) KW - Cortex (temporal) KW - Cortex (cingulate) KW - Decision making KW - Reaction time task KW - Cortex (visual) KW - Amygdala KW - Language KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+impact+of+affect+and+frequency+on+lexical+decision%3A+The+role+of+the+amygdala+and+inferior+frontal+cortex&rft.au=Nakic%2C+Marina%3BSmith%2C+Bruce+W%3BBusis%2C+Sarah%3BVythilingam%2C+Meena%3BBlair%2C+RJames+R&rft.aulast=Nakic&rft.aufirst=Marina&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1752&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Language; Emotions; Cortex (frontal); Cortex (cingulate); Cortex (temporal); Amygdala; Cortex (visual); Reaction time task; Arousal; Decision making; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2006.02.022 ER - TY - JOUR T1 - Brain abnormalities in human obesity: A voxel-based morphometric study AN - 19446314; 6931161 AB - Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m super(2)) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m super(2)) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P - 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post- central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity. JF - NeuroImage AU - Pannacciulli, Nicola AU - Del Parigi, Angelo AU - Chen, Kewei AU - Le, Duc Son NT AU - Reiman, Eric M AU - Tataranni, Pietro A AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N. 16th St., Rm. 5-28, Phoenix, AZ 85016, USA, nicolap@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1419 EP - 1425 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - Physical Education Index; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Alzheimer's disease KW - Anatomy KW - Evaluation KW - Body weight KW - Weight KW - Sex KW - Handedness KW - Brain KW - Morphometry KW - Adipose tissue KW - Body fat KW - Body mass index KW - Substantia grisea KW - Body mass KW - Magnetic resonance imaging KW - Techniques KW - Putamen KW - Reward KW - Risk factors KW - Reinforcement KW - Brain architecture KW - frontal gyrus KW - Obesity KW - Taste KW - Neurodegenerative diseases KW - operculum KW - Scanning KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Brain+abnormalities+in+human+obesity%3A+A+voxel-based+morphometric+study&rft.au=Pannacciulli%2C+Nicola%3BDel+Parigi%2C+Angelo%3BChen%2C+Kewei%3BLe%2C+Duc+Son+NT%3BReiman%2C+Eric+M%3BTataranni%2C+Pietro+A&rft.aulast=Pannacciulli&rft.aufirst=Nicola&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.01.047 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Obesity; Brain; Alzheimer's disease; Evaluation; Scanning; Techniques; Reward; Risk factors; Handedness; Sex; Weight; Body mass; Magnetic resonance imaging; Neurodegenerative diseases; Body fat; Brain architecture; Body mass index; Putamen; Taste; Reinforcement; operculum; frontal gyrus; Anatomy; Morphometry; Adipose tissue; Body weight; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2006.01.047 ER - TY - JOUR T1 - Fabrication and characterization of six electrospun poly( alpha -hydroxy ester)- based fibrous scaffolds for tissue engineering applications AN - 19439289; 6868568 AB - The most common synthetic biodegradable polymers being investigated for tissue engineering applications are FDA approved, clinically used poly( alpha - hydroxy esters). To better assess the applicability of the electrospinning technology for scaffold fabrication, six commonly used poly( alpha -hydroxy esters) were used to prepare electrospun fibrous scaffolds, and their physical and biological properties were also characterized. Our results suggest that specific, optimized fabrication parameters are required for each polymer to produce scaffolds that consist of uniform structures morphologically similar to native extracellular matrix. Scanning electron microscopy (SEM) revealed a highly porous, three-dimensional structure for all scaffolds, with average fiber diameter ranging from 300 nm to 1.5 mu m, depending on the polymer type used. The poly(glycolic acid) (PGA) and poly(d,l-lactic-co-glycolic acid 50:50) (PLGA5050) fibrous structures were mechanically stiffest, whereas the poly(l- lactic acid) (PLLA) and poly( epsilon -caprolactone) (PCL) scaffolds were most compliant. Upon incubation in physiological solution, severe structural destruction due to polymer degradation was found in the PGA, poly(d,l-lactic acid) (PDLLA), PLGA5050, and poly(d,l-lactic-co-glycolic acid 85:15) (PLGA8515) fibrous scaffolds, whereas PLLA and PCL fibrous scaffolds maintained a robust scaffold structure during the same time period, based on macroscopic and SEM observations. In addition, PLLA scaffolds supported the highest rate of proliferation of seeded cells (chondrocytes and mesenchymal stem cells) than other polymeric scaffolds. Our findings showed that PLLA and PCL based fibrous scaffolds exhibited the most optimal structural integrity and supported desirable cellular response in culture, suggesting that such scaffolds may be promising candidate biomaterials for tissue engineering applications. JF - Acta Biomaterialia AU - Li, Wan-Ju AU - Cooper, James A AU - Mauck, Robert L AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Room 1523, Bldg 50, MSC 8022, Department of Health and Human Services, Bethesda, MD 20892, United States, tuanr@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 377 EP - 385 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 2 IS - 4 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Scanning electron microscopy KW - Chondrocytes KW - polylactic acid KW - Cell culture KW - Esters KW - Tissue engineering KW - scaffolds KW - Fibers KW - Stem cells KW - Extracellular matrix KW - Lactic acid KW - Biomaterials KW - Cell proliferation KW - Mesenchyme KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Fabrication+and+characterization+of+six+electrospun+poly%28+alpha+-hydroxy+ester%29-+based+fibrous+scaffolds+for+tissue+engineering+applications&rft.au=Li%2C+Wan-Ju%3BCooper%2C+James+A%3BMauck%2C+Robert+L%3BTuan%2C+Rocky+S&rft.aulast=Li&rft.aufirst=Wan-Ju&rft.date=2006-07-01&rft.volume=2&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2006.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - scaffolds; polylactic acid; Tissue engineering; Esters; Stem cells; Chondrocytes; Biomaterials; Mesenchyme; Cell culture; Cell proliferation; Scanning electron microscopy; Extracellular matrix; Fibers; Lactic acid DO - http://dx.doi.org/10.1016/j.actbio.2006.02.005 ER - TY - JOUR T1 - Serum Concentrations of 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and Risk of Primary Liver Cancer AN - 19367881; 7129144 AB - BACKGROUND: 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) exposure has been demonstrated to cause liver tumors in laboratory rodents. DDT's persistent metabolite and environmental degradation product, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also been associated with liver tumors in laboratory animals. Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear. METHODS: We carried out a nested case-control study among the participants of the Nutritional Intervention Trials in Linxian, China. The case group included 168 individuals who developed liver cancer during the trials, and the control group included 385 individuals frequency-matched on age and sex who were alive and well at the end of the study. Serum concentrations of DDT and DDE were measured by gas chromatography-mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable analysis. RESULTS: In multivariable-adjusted models, the risk of developing liver cancer increased with increased serum DDT concentration (OR for quintile 1 versus quintile 5 = 3.8, 95% CI = 1.7 to 8.6, P sub(trend) = .0024). In contrast, there was no statistically significant association between liver cancer and serum DDE concentration. The association between high serum DDT concentration and liver cancer was stronger among individuals with DDE concentrations below the median value (odds ratio for tertile 3 versus tertile 1 = 3.55, 95% CI = 1.45 to 8.74) than those with concentrations above the median (OR = 1.70, 95% CI = 0.97 to 2.98). A calculation of crude liver cancer risk found that there would be 26 liver cancers per 100 000 persons per year in the lowest quintile of DDT exposure versus 46 liver cancers per 100 000 persons per year in the highest quintile of DDT exposure. CONCLUSIONS: DDT may be a risk factor for liver cancer, particularly among persons with lower DDE concentrations. Risk may be particularly increased among persons exposed directly to DDT (resulting in a higher ratio of DDT to DDE) or, alternatively, risk may be associated with individual ability to metabolize DDT to DDE. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Zhang, Mingdong AU - Sun, Xiu-Di AU - Fan, Jin-Hu AU - O'Brien, Thomas R AU - Wei, Wen-Qiang AU - Ortiz-Conde, Betty A AU - Dawsey, Sanford M AU - Weber, Jean-Philippe AU - Taylor, Philip R AU - Katki, Hormuzd AU - Mark, Steven D AU - Qiao, You-Lin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (KAM, CCA, MZ, TRO, SMD, PRT, HK, SDM) Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1005 EP - 1010 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts KW - Environmental degradation KW - Liver cancer KW - DDE KW - Laboratory animals KW - Statistical analysis KW - Metabolites KW - Tumors KW - Cancer KW - Mass spectroscopy KW - Spectrometry KW - Models KW - Insecticides KW - Nitrous oxide KW - Gas chromatography KW - Risk factors KW - DDT KW - Liver KW - China, People's Rep. KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Serum+Concentrations+of+1%2C1%2C1-Trichloro-2%2C2-bis%28p-chlorophenyl%29ethane+%28DDT%29+and+1%2C1-Dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+Risk+of+Primary+Liver+Cancer&rft.au=McGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BZhang%2C+Mingdong%3BSun%2C+Xiu-Di%3BFan%2C+Jin-Hu%3BO%27Brien%2C+Thomas+R%3BWei%2C+Wen-Qiang%3BOrtiz-Conde%2C+Betty+A%3BDawsey%2C+Sanford+M%3BWeber%2C+Jean-Philippe%3BTaylor%2C+Philip+R%3BKatki%2C+Hormuzd%3BMark%2C+Steven+D%3BQiao%2C+You-Lin&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2006-07-01&rft.volume=98&rft.issue=14&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Environmental degradation; Gas chromatography; Risk factors; Liver cancer; DDE; DDT; Statistical analysis; Laboratory animals; Metabolites; Tumors; Mass spectroscopy; Models; Insecticides; Nitrous oxide; Liver; Cancer; Spectrometry; China, People's Rep. ER - TY - JOUR T1 - Characterization of polar brevetoxin derivatives isolated from Karenia brevis cultures and natural blooms AN - 19290634; 6985236 AB - Several novel brevetoxin derivatives were isolated and identified in Karenia brevis cultures and natural blooms by using solid phase extraction (SPE) and LC/MS(MS) techniques. These analogs were more polar compared with previously described brevetoxins, and were poorly extractable by conventional non-polar solvent (chloroform) partitioning. Brevetoxin analogs were structurally confirmed as hydrolyzed (open A-ring) forms of brevetoxins PbTx-1, PbTx-7, PbTx-2, and PbTx-3, and of oxidized PbTx-1 and PbTx-2. Some of these open A-ring derivatives were in greater abundance than their non-hydrolyzed counterparts. All were in much greater abundance in bloom water filtrate compared with cell-rich fractions. Open A-ring compounds were cytotoxic in mouse neuroblastoma (N2a) cell assay. In the K. brevis bloom-exposed Eastern oyster, brevetoxin metabolites with opened A rings were identified (e.g., open- ring cysteine-PbTx conjugates), contributing to their overall toxin burden. JF - Toxicon AU - Abraham, Ann AU - Plakas, Steven M AU - Wang, Zhihong AU - Jester, Edward LE AU - El Said, Kathleen R AU - Granade, Hudson R AU - Henry, Michael S AU - Blum, Patricia C AU - Pierce, Richard H AU - Dickey, Robert W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA, ann.abraham@fda.hhs.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 104 EP - 115 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 48 IS - 1 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Brevetoxins KW - Karenia brevis KW - Eastern oyster KW - LC/MS KW - Molecular structure KW - Marine KW - Algal blooms KW - Toxicants KW - Analogs KW - Solvents KW - Phytoplankton KW - Cell culture KW - Metabolites KW - Animal physiology KW - Toxicity KW - Toxins KW - Neuroblastoma KW - Chloroform KW - Cytotoxicity KW - K 03410:Animal Diseases KW - Q1 08461:Plankton KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19290634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Characterization+of+polar+brevetoxin+derivatives+isolated+from+Karenia+brevis+cultures+and+natural+blooms&rft.au=Abraham%2C+Ann%3BPlakas%2C+Steven+M%3BWang%2C+Zhihong%3BJester%2C+Edward+LE%3BEl+Said%2C+Kathleen+R%3BGranade%2C+Hudson+R%3BHenry%2C+Michael+S%3BBlum%2C+Patricia+C%3BPierce%2C+Richard+H%3BDickey%2C+Robert+W&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2006-07-01&rft.volume=48&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2006.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Molecular structure; Algal blooms; Toxicants; Analogs; Solvents; Phytoplankton; Animal physiology; Metabolites; Toxicity; Chloroform; Cytotoxicity; Brevetoxins; Cell culture; Neuroblastoma; Toxins; Karenia brevis; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2006.04.015 ER - TY - JOUR T1 - Functional Heterogeneity of RpoS in Stress Tolerance of Enterohemorrhagic Escherichia coli Strains AN - 17264482; 6992642 AB - The stationary-phase sigma factor (RpoS) regulates many cellular responses to environmental stress conditions such as heat, acid, and alkali shocks. On the other hand, mutations at the rpoS locus have frequently been detected among pathogenic as well as commensal strains of Escherichia coli. The objective of this study was to perform a functional analysis of the RpoS-mediated stress responses of enterohemorrhagic E. coli strains from food-borne outbreaks. E. coli strains belonging to serotypes O157:H7, O111:H11, and O26:H11 exhibited polymorphisms for two phenotypes widely used to monitor rpoS mutations, heat tolerance and glycogen synthesis, as well as for two others, alkali tolerance and adherence to Caco-2 cells. However, these strains synthesized the oxidative acid resistance system through an rpoS-dependent pathway. During the transition from mildly acidic growth conditions (pH 5.5) to alkaline stress (pH 10.2), cell survival was dependent on rpoS functionality. Some strains were able to overcome negative regulation by RpoS and induced higher {szligbeta}-galactosidase activity without compromising their acid resistance. There were no major differences in the DNA sequences in the rpoS coding regions among the tested strains. The heterogeneity of rpoS-dependent phenotypes observed for stress-related phenotypes was also evident in the Caco-2 cell adherence assay. Wild-type O157:H7 strains with native rpoS were less adherent than rpoS-complemented counterpart strains, suggesting that rpoS functionality is needed. These results show that some pathogenic E. coli strains can maintain their acid tolerance capability while compromising other RpoS-dependent stress responses. Such adaptation processes may have significant impact on a pathogen's survival in food processing environments, as well in the host's stomach and intestine. JF - Applied and Environmental Microbiology AU - Bhagwat, Arvind A AU - Tan, Jasmine AU - Sharma, Manan AU - Kothary, Mahendra AU - Low, Sharon AU - Tall, Ben D AU - Bhagwat, Medha AD - Produce Quality and Safety Laboratory. Food Technology and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, Maryland 20705-2350. Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland 20708. National Center for Biotechnology Information, Bldg. 38A, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 4978 EP - 4986 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 7 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Food processing KW - Serotypes KW - Adaptations KW - Growth conditions KW - Nucleotide sequence KW - Commensals KW - Heat tolerance KW - Glycogen KW - Shock KW - Heat KW - Escherichia coli KW - Intestine KW - Environmental stress KW - Sigma factor KW - Alkalis KW - Mutation KW - pH effects KW - Stomach KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Functional+Heterogeneity+of+RpoS+in+Stress+Tolerance+of+Enterohemorrhagic+Escherichia+coli+Strains&rft.au=Bhagwat%2C+Arvind+A%3BTan%2C+Jasmine%3BSharma%2C+Manan%3BKothary%2C+Mahendra%3BLow%2C+Sharon%3BTall%2C+Ben+D%3BBhagwat%2C+Medha&rft.aulast=Bhagwat&rft.aufirst=Arvind&rft.date=2006-07-01&rft.volume=72&rft.issue=7&rft.spage=4978&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Cell survival; Adaptations; Serotypes; Growth conditions; Nucleotide sequence; Heat tolerance; Commensals; Glycogen; Shock; Heat; Intestine; Environmental stress; Alkalis; Sigma factor; pH effects; Mutation; Stomach; Escherichia coli ER - TY - JOUR T1 - Retrospective Assessment of Radiation Exposure Using Biological Dosimetry: Chromosome Painting, Electron Paramagnetic Resonance and the Glycophorin A Mutation Assay AN - 17264168; 7002787 AB - Biological monitoring of dose can contribute important, independent estimates of cumulative radiation exposure in epidemiological studies, especially in studies in which the physical dosimetry is lacking. Three biodosimeters that have been used in epidemiological studies to estimate past radiation exposure from external sources will be highlighted: chromosome painting or FISH (fluorescence in situ hybridization), the glycophorin A somatic mutation assay (GPA), and electron paramagnetic resonance (EPR) with teeth. All three biodosimeters have been applied to A-bomb survivors, Chernobyl clean-up workers, and radiation workers. Each biodosimeter has unique advantages and limitations depending upon the level and type of radiation exposure. Chromosome painting has been the most widely applied biodosimeter in epidemiological studies of past radiation exposure, and results of these studies provide evidence that dose-related translocations persist for decades. EPR tooth dosimetry has been used to validate dose models of acute and chronic radiation exposure, although the present requirement of extracted teeth has been a disadvantage. GPA has been correlated with physically based radiation dose after high-dose, acute exposures but not after low-dose, chronic exposures. Interindividual variability appears to be a limitation for both chromosome painting and GPA. Both of these techniques can be used to estimate the level of past radiation exposure to a population, whereas EPR can provide individual dose estimates of past exposure. This paper will review each of these three biodosimeters and compare their application in selected epidemiological studies. JF - Radiation Research AU - Kleinerman, R A AU - Romanyukha, A A AU - Schauer, DA AU - Tucker, J D AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 287 EP - 302 PB - Radiation Research Society VL - 166 IS - 1 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; Toxicology Abstracts KW - E.S.R. KW - Teeth KW - alpha Radiation KW - Dosimetry KW - Models KW - Workers KW - Chromosomes KW - Chromosome translocations KW - Radiation KW - Chronic exposure KW - Reviews KW - Mutation KW - Translocation KW - Fluorescence in situ hybridization KW - X 24390:Radioactive Materials KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Retrospective+Assessment+of+Radiation+Exposure+Using+Biological+Dosimetry%3A+Chromosome+Painting%2C+Electron+Paramagnetic+Resonance+and+the+Glycophorin+A+Mutation+Assay&rft.au=Kleinerman%2C+R+A%3BRomanyukha%2C+A+A%3BSchauer%2C+DA%3BTucker%2C+J+D&rft.aulast=Kleinerman&rft.aufirst=R&rft.date=2006-07-01&rft.volume=166&rft.issue=1&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR3273.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=166&issue=1&page=287 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Teeth; E.S.R.; alpha Radiation; Dosimetry; Models; Workers; Chromosomes; Radiation; Chromosome translocations; Chronic exposure; Reviews; Translocation; Mutation; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1667/RR3273.1 ER - TY - JOUR T1 - National Estimates of Hospital Use by Children With HIV Infection in the United States: Analysis of Data From the 2000 KIDS Inpatient Database AN - 17254807; 6998593 AB - OBJECTIVES. The purpose of this research was to describe hospital use patterns of HIV-infected children in the United States. STUDY DESIGN. We analyzed a nationwide, stratified probability sample of 2.5 million hospital discharges of children and adolescents during the year 2000, weighted to 7.3 million discharges nationally. We excluded discharges after hospitalizations related to pregnancy/childbirth and their complications and discharges of neonates 18 years of age. Diagnoses were identified through the use of the Clinical Classification Software with grouping of related diagnoses. RESULTS. We estimated that there were 4107 hospitalizations of HIV-infected children in 2000 and that these hospitalizations accounted for similar to $100 million in hospital charges and >30000 hospital days. Infections, including sepsis and pneumonia, were among the most frequent diagnoses in such hospitalizations, followed by diagnoses related to gastrointestinal conditions, nutritional deficiencies and anemia, fluid/electrolyte disorders, central nervous system disorders, cardiovascular disorders, and respiratory illnesses. Compared with hospitalizations of non-HIV-infected children, hospitalizations of HIV-infected ones were more likely to be in urban areas, in pediatric/teaching hospitals, and in the Northeast, and the expected payer was more likely to be Medicaid (77.6% vs 37.2%). Compared with children without HIV, those with HIV tended to be older (median age: 9.5 years vs 5.2 years), to have been hospitalized longer (mean: 7.8 days vs 3.9 days), and to have incurred higher hospital costs (mean: $23221 vs $11215); HIV-associated hospitalizations ended in the patient's death more frequently than non-HIV ones (1.8% vs 0.4%), and complications of medical care were also more common (10.8% vs 6.2%). CONCLUSIONS. Infections account for the majority of hospitalizations of HIV-infected children in the United States, although nutritional deficiencies, anemia and other hematologic disorders, gastrointestinal and renal disorders, and complications of medical care are also more common among hospitalized children with HIV than among those without HIV. JF - Pediatrics AU - Kourtis, Athena P AU - Paramsothy, Pangaja AU - Posner, Samuel F AU - Meikle, Susan F AU - Jamieson, Denise J AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Eastern Virginia Medical School, Norfolk, Virginia. CONRAD Program, Arlington, Virginia. Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - e167 EP - e173 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 118 IS - 1 SN - 0031-4005, 0031-4005 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Central nervous system KW - Age KW - Data processing KW - Pediatrics KW - Adolescence KW - Anemia KW - Children KW - Infection KW - Pregnancy KW - Computer programs KW - Databases KW - Nutrient deficiency KW - Sepsis KW - software KW - Classification KW - Human immunodeficiency virus KW - Kidney KW - Geriatrics KW - Neonates KW - Pneumonia KW - Hospitals KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17254807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=National+Estimates+of+Hospital+Use+by+Children+With+HIV+Infection+in+the+United+States%3A+Analysis+of+Data+From+the+2000+KIDS+Inpatient+Database&rft.au=Kourtis%2C+Athena+P%3BParamsothy%2C+Pangaja%3BPosner%2C+Samuel+F%3BMeikle%2C+Susan+F%3BJamieson%2C+Denise+J&rft.aulast=Kourtis&rft.aufirst=Athena&rft.date=2006-07-01&rft.volume=118&rft.issue=1&rft.spage=e167&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Central nervous system; Age; Data processing; Pediatrics; Adolescence; Anemia; Infection; Children; Pregnancy; Databases; Computer programs; software; Sepsis; Nutrient deficiency; Classification; Geriatrics; Kidney; Neonates; Pneumonia; Hospitals; Human immunodeficiency virus ER - TY - JOUR T1 - "Islands of Risk": Subgroups of Adolescents at Risk for HIV AN - 17254349; 6997643 AB - OBJECTIVE: To use cluster analysis to determine profiles of adolescents at risk for HIV. METHODS: Adolescents 15-21 years old (N = 1153) with a history of unprotected sex were assessed in five domains of risk (unprotected sex, alcohol/marijuana use, other drug use, mental health crises, and arrest/school dropout) as well as demographic, contextual, and behavioral variables. RESULTS: Cluster analysis revealed separate three-cluster solutions for males and females. Among males, clusters were characterized by (a) mental health crises and unprotected sex, (b) alcohol/marijuana use and unprotected sex, and (c) lower risk. Among females, clusters were distinguished by (a) unprotected sex, (b) substance use and mental health crises, and (c) lower risk. Cluster membership was associated with secondary variables related to sexual risk. CONCLUSIONS: Even within populations of high-risk adolescents, subgroups exist for which specific risk factors co-occur, particularly unprotected sex, mental health crises, and substance use. These patterns suggest that effective HIV prevention interventions may need to target the association between mental health and/or substance abuse with sexual risk for some adolescents. JF - Journal of Pediatric Psychology AU - Houck, Christopher D AU - Lescano, Celia M AU - Brown, Larry K AU - Tolou-Shams, Marina AU - Thompson, Jonathon AU - DiClemente, Ralph AU - Fernandez, MIsabel AU - Pugatch, David AU - Schlenger, William E AU - Silver, Barbara J AD - Rhode Island Hospital and Brown Medical School, Emory University, University of Miami, Research Triangle Institute, and Substance Abuse and Mental Health Services Administration Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 619 EP - 629 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 31 IS - 6 SN - 0146-8693, 0146-8693 KW - Risk Abstracts KW - substance abuse KW - Alcohol KW - Historical account KW - Mental disorders KW - Human immunodeficiency virus KW - Psychology KW - prevention KW - Drug abuse KW - Sexual behavior KW - Adolescents KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17254349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=%22Islands+of+Risk%22%3A+Subgroups+of+Adolescents+at+Risk+for+HIV&rft.au=Houck%2C+Christopher+D%3BLescano%2C+Celia+M%3BBrown%2C+Larry+K%3BTolou-Shams%2C+Marina%3BThompson%2C+Jonathon%3BDiClemente%2C+Ralph%3BFernandez%2C+MIsabel%3BPugatch%2C+David%3BSchlenger%2C+William+E%3BSilver%2C+Barbara+J&rft.aulast=Houck&rft.aufirst=Christopher&rft.date=2006-07-01&rft.volume=31&rft.issue=6&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - substance abuse; Historical account; Alcohol; Mental disorders; Psychology; prevention; Drug abuse; Sexual behavior; Adolescents; Human immunodeficiency virus ER - TY - JOUR T1 - Real-time, quantitative PCR assays for the detection of virus-specific DNA in samples with mixed populations of polyomaviruses AN - 17209532; 6909640 AB - Mixtures of polyomaviruses can be present in the central nervous system, the gastrointestinal tract, the genitourinary tract, blood, and urban sewage. We have developed 12 primer/probe sets (four per virus) for real-time, quantitative PCR assays (TaqMan) that can specifically detect BKV, JCV, and SV40 genomes present in mixtures of these viruses. The specificities of these primer/probe sets were determined by evaluating their level of interaction with the DNA from other polyomaviruses and their ability to estimate the number of copies of homologous viral DNA in blinded samples of defined mixtures of three polyomaviral DNAs. Three early region and three late region primer/probe sets determined, within a two-fold range, the number of copies of their respective DNAs. Four sets of SV40 primer/probes also detected 1.1-2.4 copies of SV40 DNA per COS-1 cell, cells estimated to contain a single copy of SV40 DNA. Three JCV primer/probe sets detected 3.7-4.2 copies per cell of JCV DNA in the JCV-transformed cell line M1-HR, cells estimated to contain between 0.5 and 1 copy of the JCV genome. We suggest that the virus-specific primer/probe sets in this study be considered sufficiently characterized to initiate the quantification of polyomavirus DNA in biological samples. JF - Journal of Virological Methods AU - Pal, A AU - Sirota, L AU - Maudru, T AU - Peden, K AU - Lewis, A M AD - Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States, lewisa@cber.fda.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 32 EP - 42 VL - 135 IS - 1 SN - 0166-0934, 0166-0934 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Genomes KW - Central nervous system KW - DNA probes KW - Polyomavirus KW - Genitourinary tract KW - Late region KW - JC virus KW - Blood KW - Digestive tract KW - Sewage KW - Early region KW - Simian virus 40 KW - Polymerase chain reaction KW - Primers KW - Gastrointestinal tract KW - A 01114:Viruses KW - N 14810:Methods KW - V 22121:Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17209532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Real-time%2C+quantitative+PCR+assays+for+the+detection+of+virus-specific+DNA+in+samples+with+mixed+populations+of+polyomaviruses&rft.au=Pal%2C+A%3BSirota%2C+L%3BMaudru%2C+T%3BPeden%2C+K%3BLewis%2C+A+M&rft.aulast=Pal&rft.aufirst=A&rft.date=2006-07-01&rft.volume=135&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2006.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Blood; Central nervous system; Digestive tract; Sewage; Early region; DNA probes; Polymerase chain reaction; Genitourinary tract; Primers; Gastrointestinal tract; Late region; Simian virus 40; Polyomavirus; JC virus DO - http://dx.doi.org/10.1016/j.jviromet.2006.01.018 ER - TY - JOUR T1 - Ignition of hydraulic fluid sprays by open flames and hot surfaces AN - 17082746; 6708350 AB - A study of the ignition of non-fire-resistant hydraulic fluid sprays was conducted by the National Institute for Occupational Safety and Health. Both an open flame and a hot steel surface were used as the external heat sources. With the open flame as the heat source, the minimum oil temperature and minimum spray nozzle pressure that resulted in an ignition were measured. The effects of the distance between the open flame and the nozzle and the nozzle orifice diameter on the ignitability of the hydraulic fluid sprays were examined. With the hot surface as the heat source, the minimum surface ignition temperature was determined. The degree of oil atomization and the relative direction of oil injection with respect to the hot surface are discussed. The ignition of oil sprays from the impingement of oil jets onto a vertical surface was also investigated. Finally, the results are compared with those obtained for fire-resistant hydraulic fluids. JF - Journal of Loss Prevention in the Process Industries AU - Yuan, L AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 353 EP - 361 VL - 19 IS - 4 KW - Health & Safety Science Abstracts KW - Oil KW - Hydraulics KW - Fires KW - Sprays KW - Occupational safety KW - Temperature KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17082746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Loss+Prevention+in+the+Process+Industries&rft.atitle=Ignition+of+hydraulic+fluid+sprays+by+open+flames+and+hot+surfaces&rft.au=Yuan%2C+L&rft.aulast=Yuan&rft.aufirst=L&rft.date=2006-07-01&rft.volume=19&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Loss+Prevention+in+the+Process+Industries&rft.issn=&rft_id=info:doi/10.1016%2Fj.jlp.2005.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Oil; Fires; Hydraulics; Occupational safety; Sprays; Temperature DO - http://dx.doi.org/10.1016/j.jlp.2005.09.001 ER - TY - JOUR T1 - Quantitative and confirmatory analyses of malachite green and leucomalachite green residues in fish and shrimp. AN - 68099667; 16786992 AB - Liquid chromatographic methods are presented for the quantitative and confirmatory determination of malachite green (MG) and leucomalachite green (LMG) for channel catfish, rainbow trout, tilapia, basa, Atlantic salmon, and tiger shrimp. Residues were extracted from tissues with ammonium acetate buffer and acetonitrile and isolated by partitioning into dichloromethane. LMG was quantitatively oxidized to the chromic MG with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Extracts were analyzed for total MG by liquid chromatography with both visible detection (LC-VIS) at 618 nm for routine screening and ion trap mass spectrometry (LC-MSn) with no discharge-atmospheric pressure chemical ionization for residue confirmation. The method was validated in each species fortified with LMG at 1, 2, 4, and 10 ng/g (ppb), and average recoveries ranged from 85.9 to 93.9%. Quantitative data were consistent for the two detection methods, with measured method detection limits of 1.0 ng/g for LC-VIS and 0.25 ng/g for LC-MSn. Incurred tissues from catfish, trout, tilapia, and salmon that had been treated with MG were also extracted and analyzed as part of this study. JF - Journal of agricultural and food chemistry AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Roybal, José E AD - Animal Drugs Research Center, Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087, USA. Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 SP - 4517 EP - 4523 VL - 54 IS - 13 SN - 0021-8561, 0021-8561 KW - Aniline Compounds KW - 0 KW - Rosaniline Dyes KW - malachite green KW - 12058M7ORO KW - leucomalachite green KW - 8U61G37Z20 KW - Index Medicus KW - Animals KW - Chromatography, Liquid -- methods KW - Ictaluridae KW - Oncorhynchus mykiss KW - Tilapia KW - Aquaculture KW - Salmo salar KW - Penaeidae KW - Fishes KW - Food Contamination -- analysis KW - Aniline Compounds -- analysis KW - Rosaniline Dyes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68099667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Quantitative+and+confirmatory+analyses+of+malachite+green+and+leucomalachite+green+residues+in+fish+and+shrimp.&rft.au=Andersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BRoybal%2C+Jos%C3%A9+E&rft.aulast=Andersen&rft.aufirst=Wendy&rft.date=2006-06-28&rft.volume=54&rft.issue=13&rft.spage=4517&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - US FDA Regulation of Computerized and Robotic Surgical Systems T2 - 10th Annual Conference of the International Society for Computer Aided Surgery (ISCAS) AN - 40122576; 4260572 JF - 10th Annual Conference of the International Society for Computer Aided Surgery (ISCAS) AU - Yen, D AU - Roxolana, H AU - Neil, O Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - FDA KW - Robotics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40122576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Conference+of+the+International+Society+for+Computer+Aided+Surgery+%28ISCAS%29&rft.atitle=US+FDA+Regulation+of+Computerized+and+Robotic+Surgical+Systems&rft.au=Yen%2C+D%3BRoxolana%2C+H%3BNeil%2C+O&rft.aulast=Yen&rft.aufirst=D&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Conference+of+the+International+Society+for+Computer+Aided+Surgery+%28ISCAS%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cars-int.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current Status of TB Vaccine Development T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40211491; 4334890 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Brennan, Michael J Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40211491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Current+Status+of+TB+Vaccine+Development&rft.au=Brennan%2C+Michael+J&rft.aulast=Brennan&rft.aufirst=Michael&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patient Reported Outcome Measures in Clinical Trials of Infectious Diseases: How they can Help us T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208749; 4334886 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Burke, Laurie B Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Patient+Reported+Outcome+Measures+in+Clinical+Trials+of+Infectious+Diseases%3A+How+they+can+Help+us&rft.au=Burke%2C+Laurie+B&rft.aulast=Burke&rft.aufirst=Laurie&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiological Cut-Off Values for Four Antimicrobial Agents against Aeromonas salmonicida Isolates using MIC and Zone Diameter Frequency Distributions T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208360; 4334914 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Miller, R A AU - Walker, R D AU - Reimschuessel, R Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Fish diseases KW - Bacterial diseases KW - Aeromonas salmonicida UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Epidemiological+Cut-Off+Values+for+Four+Antimicrobial+Agents+against+Aeromonas+salmonicida+Isolates+using+MIC+and+Zone+Diameter+Frequency+Distributions&rft.au=Miller%2C+R+A%3BWalker%2C+R+D%3BReimschuessel%2C+R&rft.aulast=Miller&rft.aufirst=R&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pandemic Flu Preparedness and Emerging Resistance in Flu Strains T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208326; 4334891 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Robinson, Robin Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Pandemics KW - Strains UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Pandemic+Flu+Preparedness+and+Emerging+Resistance+in+Flu+Strains&rft.au=Robinson%2C+Robin&rft.aulast=Robinson&rft.aufirst=Robin&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptive Designs in Clinical Trials of Infectious Diseases: What it is and What it isnt T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40208191; 4334887 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Lin, Daphne T.Y. 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T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40207648; 4334888 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Powers, John H Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40207648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Increasing+the+Efficiency+of+Clinical+Trials+in+Infectious+Diseases%3A+Where+do+we+go+from+here%3F&rft.au=Powers%2C+John+H&rft.aulast=Powers&rft.aufirst=John&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Misclassification Bias and Measurement Error in Clinical Trials for Infectious Diseases: How they Affect the Efficiency of Trials T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40202958; 4334885 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Cooper, Charles K Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Clinical trials KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40202958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Misclassification+Bias+and+Measurement+Error+in+Clinical+Trials+for+Infectious+Diseases%3A+How+they+Affect+the+Efficiency+of+Trials&rft.au=Cooper%2C+Charles+K&rft.aulast=Cooper&rft.aufirst=Charles&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aminoglycoside Resistance Genes Found in Enterococcus spp. Recovered from Retail Meats T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40199545; 4334901 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Bodeis-Jones, S M AU - White, D G Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Meat KW - Enterococcus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40199545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Aminoglycoside+Resistance+Genes+Found+in+Enterococcus+spp.+Recovered+from+Retail+Meats&rft.au=Bodeis-Jones%2C+S+M%3BWhite%2C+D+G&rft.aulast=Bodeis-Jones&rft.aufirst=S&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Local Perspective: The Sanitarian's Role During Disaster Relief Efforts T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40178122; 4323295 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bhatt, Chirag H Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Disasters KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40178122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Local+Perspective%3A+The+Sanitarian%27s+Role+During+Disaster+Relief+Efforts&rft.au=Bhatt%2C+Chirag+H&rft.aulast=Bhatt&rft.aufirst=Chirag&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What is Reduced-Oxygen Packaging and What are the Food Safety Concerns and Controls? T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40177759; 4323177 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bohm, Shirley B Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Packaging KW - Food KW - Public health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40177759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=What+is+Reduced-Oxygen+Packaging+and+What+are+the+Food+Safety+Concerns+and+Controls%3F&rft.au=Bohm%2C+Shirley+B&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Federal Perspective: CDC Response to Environmental Health Concerns from Hurricane Katrina in New Orleans T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40176507; 4323297 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Manwaring, Jan C AU - Herring, Michael E Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - USA, Louisiana, New Orleans KW - Hurricanes KW - Environmental health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40176507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Federal+Perspective%3A+CDC+Response+to+Environmental+Health+Concerns+from+Hurricane+Katrina+in+New+Orleans&rft.au=Manwaring%2C+Jan+C%3BHerring%2C+Michael+E&rft.aulast=Manwaring&rft.aufirst=Jan&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perception as RealityStrengths, Successes, and Solutions to Community-Based Sheltering T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40176185; 4323196 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Bhatt, Chirag H AU - Bock, Courtney AU - Frank, Cory AU - Lane, Janet AU - Maloney, Joe AU - Miller, Mark D Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Perception KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40176185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Perception+as+RealityStrengths%2C+Successes%2C+and+Solutions+to+Community-Based+Sheltering&rft.au=Bhatt%2C+Chirag+H%3BBock%2C+Courtney%3BFrank%2C+Cory%3BLane%2C+Janet%3BMaloney%2C+Joe%3BMiller%2C+Mark+D&rft.aulast=Bhatt&rft.aufirst=Chirag&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Controlling Foodborne Viruses: Moving into the Next Millenium of Food Safety T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40175161; 4323302 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Fanaselle, Wendy Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Viruses KW - Food KW - Public health KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40175161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Controlling+Foodborne+Viruses%3A+Moving+into+the+Next+Millenium+of+Food+Safety&rft.au=Fanaselle%2C+Wendy&rft.aulast=Fanaselle&rft.aufirst=Wendy&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethnic Foods: Meeting the Challenge T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40173036; 4323265 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Chamberlin, Clint R Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Food KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40173036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Ethnic+Foods%3A+Meeting+the+Challenge&rft.au=Chamberlin%2C+Clint+R&rft.aulast=Chamberlin&rft.aufirst=Clint&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple SalmonellaOutbreaks Associated with Tomatoes, 2004 T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40168780; 4323306 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Hill, Thomas A Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Environmental health KW - Education KW - Lycopersicon esculentum KW - Salmonidae KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40168780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Multiple+SalmonellaOutbreaks+Associated+with+Tomatoes%2C+2004&rft.au=Hill%2C+Thomas+A&rft.aulast=Hill&rft.aufirst=Thomas&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Seal Quality and Imperfections in Flexible Pouches by Infrared Imaging Thermography T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144718; 4293744 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Song, Y AU - Setikaite, I AU - Hancock, E AU - Sadler, G Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Thermography KW - Marine mammals KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Evaluation+of+Seal+Quality+and+Imperfections+in+Flexible+Pouches+by+Infrared+Imaging+Thermography&rft.au=Song%2C+Y%3BSetikaite%2C+I%3BHancock%2C+E%3BSadler%2C+G&rft.aulast=Song&rft.aufirst=Y&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Medium and Incubation Conditions on Recovery of High Pressure-Injured Clostridium Botulinum Spores T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144412; 4293629 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Reddy, N AU - Tetzloff, R Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Spores KW - Clostridium botulinum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Effect+of+Medium+and+Incubation+Conditions+on+Recovery+of+High+Pressure-Injured+Clostridium+Botulinum+Spores&rft.au=Reddy%2C+N%3BTetzloff%2C+R&rft.aulast=Reddy&rft.aufirst=N&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of CO@@d2@ and O@@d2@ on High Pressure Inactivation of Listeria Innocua T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40144298; 4293626 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Murakami, E AU - Larkin, J AU - Ravishankar, S AU - Chen, L AU - Patazca, E AU - Chirtel, S Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Carbon dioxide KW - Pressure KW - Listeria innocua UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40144298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=The+Effect+of+CO%40%40d2%40+and+O%40%40d2%40+on+High+Pressure+Inactivation+of+Listeria+Innocua&rft.au=Murakami%2C+E%3BLarkin%2C+J%3BRavishankar%2C+S%3BChen%2C+L%3BPatazca%2C+E%3BChirtel%2C+S&rft.aulast=Murakami&rft.aufirst=E&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thermal Stability of Ricin in Infant Formula T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40124284; 4293223 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Jackson, L AU - Tolleson, W AU - Palucki, D Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Infant formulas KW - Ricin KW - Thermal stability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Thermal+Stability+of+Ricin+in+Infant+Formula&rft.au=Jackson%2C+L%3BTolleson%2C+W%3BPalucki%2C+D&rft.aulast=Jackson&rft.aufirst=L&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Intake Estimate of Folic Acid in the U.S. Population T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40078268; 4293381 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Lee, H Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - USA KW - Dietary intake KW - Folic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Dietary+Intake+Estimate+of+Folic+Acid+in+the+U.S.+Population&rft.au=Lee%2C+H&rft.aulast=Lee&rft.aufirst=H&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multilocus Sequence Analysis of Housekeeping Genes of the Mycoplasma and Acholeplasma Genera: Phylogeny and Species Identification T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40116995; 4258744 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Volokhov, D V AU - George, J AU - Neverov, A A AU - Ikonomi, P AU - Anderson, C M AU - Chizhikov, V E Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Phylogeny KW - Nucleotide sequence KW - Acholeplasma KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Multilocus+Sequence+Analysis+of+Housekeeping+Genes+of+the+Mycoplasma+and+Acholeplasma+Genera%3A+Phylogeny+and+Species+Identification&rft.au=Volokhov%2C+D+V%3BGeorge%2C+J%3BNeverov%2C+A+A%3BIkonomi%2C+P%3BAnderson%2C+C+M%3BChizhikov%2C+V+E&rft.aulast=Volokhov&rft.aufirst=D&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Response after Hurricane Katrina by the Houston and Harris County Departments of Health T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 39999813; 4257924 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Arafat, R AU - Palacio, H AU - Shah, U Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - USA, Texas, Houston KW - Public health KW - Hurricanes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39999813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Public+Health+Response+after+Hurricane+Katrina+by+the+Houston+and+Harris+County+Departments+of+Health&rft.au=Arafat%2C+R%3BPalacio%2C+H%3BShah%2C+U&rft.aulast=Arafat&rft.aufirst=R&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Medical devices; exception from general requirements for informed consent. Interim final rule. AN - 68575102; 16795934 AB - The Food and Drug Administration (FDA) is issuing this interim final rule to amend its regulations to establish a new exception from the general requirements for informed consent, to permit the use of investigational in vitro diagnostic devices to identify chemical, biological, radiological, or nuclear agents without informed consent in certain circumstances. The agency is taking this action because it is concerned that, during a potential terrorism event or other potential public health emergency, delaying the testing of specimens to obtain informed consent may threaten the life of the subject. In many instances, there may also be others who have been exposed to, or who may be at risk of exposure to, a dangerous chemical, biological, radiological, or nuclear agent, thus necessitating identification of the agent as soon as possible. FDA is creating this exception to help ensure that individuals who may have been exposed to a chemical, biological, radiological, or nuclear agent are able to benefit from the timely use of the most appropriate diagnostic devices, including those that are investigational. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2006/06/07/ PY - 2006 DA - 2006 Jun 07 SP - 32827 EP - 32834 VL - 71 IS - 109 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Public Health -- legislation & jurisprudence KW - Humans KW - In Vitro Techniques KW - Therapies, Investigational KW - Device Approval -- legislation & jurisprudence KW - Terrorism -- legislation & jurisprudence KW - Disaster Planning -- legislation & jurisprudence KW - Informed Consent -- legislation & jurisprudence KW - Diagnostic Equipment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68575102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Medical+devices%3B+exception+from+general+requirements+for+informed+consent.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2006-06-07&rft.volume=71&rft.issue=109&rft.spage=32827&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Birth weight and breast cancer risk AN - 899129478; 13759221 AB - Exploring whether the positive association between birth weight and breast cancer risk differs by other breast cancer risk factors may help inform speculation about biological mechanism. In these data, high birth weight was associated with breast cancer risk in younger and in more educated women, but was not associated overall.British Journal of Cancer (2006) 94, 1734-1737. doi:10.1038/sj.bjc.6603122 www.bjcancer.com Published online 25 April 2006 JF - British Journal of Cancer AU - Troisi, R AU - Hatch, E E AU - Titus-Ernstoff, L AU - Palmer, J R AU - Hyer, M AU - Strohsnitter, W C AU - Robboy, S J AU - Kaufman, R AU - Herbst, A AU - Adam, E AU - Hoover, R N AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA Y1 - 2006/06/05/ PY - 2006 DA - 2006 Jun 05 SP - 1734 EP - 1737 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 94 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Breast cancer KW - birth weight KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Birth+weight+and+breast+cancer+risk&rft.au=Troisi%2C+R%3BHatch%2C+E+E%3BTitus-Ernstoff%2C+L%3BPalmer%2C+J+R%3BHyer%2C+M%3BStrohsnitter%2C+W+C%3BRobboy%2C+S+J%3BKaufman%2C+R%3BHerbst%2C+A%3BAdam%2C+E%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2006-06-05&rft.volume=94&rft.issue=11&rft.spage=1734&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - birth weight; Breast cancer; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6603122 ER - TY - JOUR T1 - UvrB Domain 4, an Autoinhibitory Gate for Regulation of DNA Binding and ATPase Activity AN - 17231352; 6947544 AB - UvrB, a central DNA damage recognition protein in bacterial nucleotide excision repair, has weak affinity for DNA, and its ATPase activity is activated by UvrA and damaged DNA. Regulation of DNA binding and ATP hydrolysis by UvrB is poorly understood. Using atomic force microscopy and biochemical assays, we found that truncation of domain 4 of Bacillus caldotenax UvrB (UvrB Delta 4) leads to multiple changes in protein function. Protein dimerization decreases with an similar to 8-fold increase of the equilibrium dissociation constant and an increase in DNA binding. Loss of domain 4 causes the DNA binding mode of UvrB to change from dimer to monomer, and affinity increases with the apparent dissociation constants on nondamaged and damaged single-stranded DNA decreasing 22- and 14-fold, respectively. ATPase activity by UvrB Delta 4 increases 14- and 9-fold with and without single-stranded DNA, respectively, and UvrB Delta 4 supports UvrA-independent damage-specific incision by Cho on a bubble DNA substrate. We propose that other than its previously discovered role in regulating protein-protein interactions, domain 4 is an autoinhibitory domain regulating the DNA binding and ATPase activities of UvrB. JF - Journal of Biological Chemistry AU - Wang, Hong AU - DellaVecchia, Matthew J AU - Skorvaga, Milan AU - Croteau, Deborah L AU - Erie, Dorothy A AU - Van Houten, Bennett AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovakia, and the Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 Y1 - 2006/06/02/ PY - 2006 DA - 2006 Jun 02 SP - 15227 EP - 15237 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Monomers KW - DNA damage KW - Adenosinetriphosphatase KW - Nucleotide excision repair KW - atomic force microscopy KW - ATP KW - Single-stranded DNA KW - Bacillus KW - Hydrolysis KW - Protein interaction KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17231352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=UvrB+Domain+4%2C+an+Autoinhibitory+Gate+for+Regulation+of+DNA+Binding+and+ATPase+Activity&rft.au=Wang%2C+Hong%3BDellaVecchia%2C+Matthew+J%3BSkorvaga%2C+Milan%3BCroteau%2C+Deborah+L%3BErie%2C+Dorothy+A%3BVan+Houten%2C+Bennett&rft.aulast=Wang&rft.aufirst=Hong&rft.date=2006-06-02&rft.volume=281&rft.issue=22&rft.spage=15227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; DNA damage; Adenosinetriphosphatase; Nucleotide excision repair; atomic force microscopy; ATP; Single-stranded DNA; Hydrolysis; Protein interaction; Bacillus ER - TY - JOUR T1 - Use of nontraditional animals for evaluation of pharmaceutical products. AN - 68670076; 16863438 AB - Although the International Conference on Harmonization Guideline ICH M3 indicates the use of nonrodents for some studies of pharmaceutical products, the specific nonrodent species is not specified. Dogs are used most frequently; however, there may be reasons why dogs are not the best model for a particular drug. Minipigs are being used increasingly for evaluation of toxicity, especially for dermally applied drugs, and for various efficacy models. Hamsters may be used for the evaluation of intraoral drugs and for carcinogenicity studies. Less commonly, pharmaceutical manufacturers may choose on their own to use marmosets, when a nonhuman primate is considered critical to evaluation, or to use ferrets for specific purposes. When nontraditional species are used, there may be less historical information available and unique issues of their care, and differences in physiology and anatomy and susceptibility to infection need to be understood. Nonmammalian test species, such as zebrafish and Caenorhabditis elegans may be used by drug sponsors in screening assays, but are not yet ready for use in pivotal toxicology studies because of the difficulty in extrapolating to mammalian species. Use of nontraditional animal species may be proposed by a drug sponsor to a reviewing division with supporting data and reasons for using a particular species. JF - Expert opinion on drug metabolism & toxicology AU - Jacobs, Abigail AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. abigail.jacobs@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 345 EP - 349 VL - 2 IS - 3 SN - 1742-5255, 1742-5255 KW - Index Medicus KW - Swine KW - Animals KW - Ferrets KW - Caenorhabditis elegans KW - Callithrix KW - Species Specificity KW - Zebrafish KW - Cricetinae KW - Models, Animal KW - Toxicity Tests -- methods KW - Drug Evaluation, Preclinical -- methods KW - Swine, Miniature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68670076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Use+of+nontraditional+animals+for+evaluation+of+pharmaceutical+products.&rft.au=Jacobs%2C+Abigail&rft.aulast=Jacobs&rft.aufirst=Abigail&rft.date=2006-06-01&rft.volume=2&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-08 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photoirradiation of retinyl palmitate in ethanol with ultraviolet light--formation of photodecomposition products, reactive oxygen species, and lipid peroxides. AN - 68616261; 16823091 AB - We have previously reported that photoirradiation of retinyl palmitate (RP), a storage and ester form of vitamin A (retinol), with UVA light resulted in the formation of photodecomposition products, generation of reactive oxygen species, and induction of lipid peroxidation. In this paper, we report our results following the photoirradiation of RP in ethanol by an UV lamp with approximately equal UVA and UVB light. The photodecomposition products were separated by reversed-phase HPLC and characterized spectroscopically by comparison with authentic standards. The identified products include: 4-keto-RP, 11-ethoxy-12-hydroxy-RP, 13-ethoxy-14-hydroxy-RP, anhydroretinol (AR), and trans- and cis-15-ethoxy-AR. Photoirradiation of RP in the presence of a lipid, methyl linoleate, resulted in induction of lipid peroxidation. Lipid peroxidation was inhibited when sodium azide was present during photoirradiation which suggests free radicals were formed. Our results demonstrate that, similar to irradiation with UVA light, RP can act as a photosensitizer leading to free radical formation and induction of lipid peroxidation following irradiation with UVB light. JF - International journal of environmental research and public health AU - Xia, Qingsu AU - Yin, Jun J AU - Wamer, Wayne G AU - Cherng, Shu-Hui AU - Boudreau, Mary D AU - Howard, Paul C AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 185 EP - 190 VL - 3 IS - 2 SN - 1661-7827, 1661-7827 KW - Linoleic Acids KW - 0 KW - Reactive Oxygen Species KW - Vitamin A KW - 11103-57-4 KW - retinol palmitate KW - 1D1K0N0VVC KW - methyl linoleate KW - 24N6726DE5 KW - Ethanol KW - 3K9958V90M KW - Sodium Azide KW - 968JJ8C9DV KW - Deuterium Oxide KW - J65BV539M3 KW - Index Medicus KW - Ethanol -- radiation effects KW - Sodium Azide -- chemistry KW - Reactive Oxygen Species -- chemistry KW - Ethanol -- chemistry KW - Deuterium Oxide -- chemistry KW - Lipid Peroxidation KW - Linoleic Acids -- radiation effects KW - Ultraviolet Rays KW - Vitamin A -- analogs & derivatives KW - Vitamin A -- chemistry KW - Vitamin A -- radiation effects KW - Linoleic Acids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68616261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Photoirradiation+of+retinyl+palmitate+in+ethanol+with+ultraviolet+light--formation+of+photodecomposition+products%2C+reactive+oxygen+species%2C+and+lipid+peroxides.&rft.au=Xia%2C+Qingsu%3BYin%2C+Jun+J%3BWamer%2C+Wayne+G%3BCherng%2C+Shu-Hui%3BBoudreau%2C+Mary+D%3BHoward%2C+Paul+C%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2006-06-01&rft.volume=3&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=16617827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-07 N1 - Date created - 2006-07-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477] Toxicol Lett. 2006 May 5;163(1):30-43 [16384671] Eye (Lond). 2001 Jun;15(Pt 3):371-5 [11450760] J Invest Dermatol. 2003 Nov;121(5):1163-7 [14708621] Curr Med Chem. 2004 May;11(9):1163-82 [15134513] Crit Rev Food Sci Nutr. 1992;31(1-2):103-63 [1734916] Cancer Res. 1994 Apr 1;54(7 Suppl):1890s-1894s [8137306] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7491-5 [8052609] Biochem Biophys Res Commun. 1995 Nov 22;216(3):1110-7 [7488187] J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511] Chem Res Toxicol. 1997 May;10(5):485-94 [9168245] Free Radic Biol Med. 1999 Jan;26(1-2):202-26 [9890655] Mutat Res. 1999 Jul 16;428(1-2):5-10 [10517972] J Nutr Sci Vitaminol (Tokyo). 1999 Jun;45(3):353-8 [10524354] Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116] Mutagenesis. 2005 Mar;20(2):81-92 [15784692] Toxicol Ind Health. 2005 Sep;21(7-8):167-75 [16149731] Toxicol Sci. 2005 Nov;88(1):142-9 [16107546] Exp Gerontol. 2001 Apr;36(4-6):619-40 [11295504] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Decision threshold adjustment in class prediction. AN - 68600916; 16815772 AB - Standard classification algorithms are generally designed to maximize the number of correct predictions (concordance). The criterion of maximizing the concordance may not be appropriate in certain applications. In practice, some applications may emphasize high sensitivity (e.g., clinical diagnostic tests) and others may emphasize high specificity (e.g., epidemiology screening studies). This paper considers effects of the decision threshold on sensitivity, specificity, and concordance for four classification methods: logistic regression, classification tree, Fisher's linear discriminant analysis, and a weighted k-nearest neighbor. We investigated the use of decision threshold adjustment to improve performance of either sensitivity or specificity of a classifier under specific conditions. We conducted a Monte Carlo simulation showing that as the decision threshold increases, the sensitivity decreases and the specificity increases; but, the concordance values in an interval around the maximum concordance are similar. For specified sensitivity and specificity levels, an optimal decision threshold might be determined in an interval around the maximum concordance that meets the specified requirement. Three example data sets were analyzed for illustrations. JF - SAR and QSAR in environmental research AU - Chen, J J AU - Tsai, C-A AU - Moon, H AU - Ahn, H AU - Young, J J AU - Chen, C-H AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. jchen@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 337 EP - 352 VL - 17 IS - 3 SN - 1062-936X, 1062-936X KW - Receptors, Estrogen KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Discriminant Analysis KW - Colonic Neoplasms -- genetics KW - Computer Simulation KW - Logistic Models KW - Artificial Intelligence KW - Humans KW - Decision Trees KW - Liver Neoplasms -- chemically induced KW - Databases, Factual KW - Algorithms KW - Receptors, Estrogen -- metabolism KW - Monte Carlo Method KW - Structure-Activity Relationship KW - Classification KW - Decision Support Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68600916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+environmental+research&rft.atitle=Decision+threshold+adjustment+in+class+prediction.&rft.au=Chen%2C+J+J%3BTsai%2C+C-A%3BMoon%2C+H%3BAhn%2C+H%3BYoung%2C+J+J%3BChen%2C+C-H&rft.aulast=Chen&rft.aufirst=J&rft.date=2006-06-01&rft.volume=17&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+environmental+research&rft.issn=1062936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-occurring disorders of adolescents in primary care: closing the gaps. AN - 68595486; 16814702 AB - The increasing prevalence of co-occurring mental health and substance use disorders in adolescents is a serious challenge for the primary care system. The needs of these youth continue to be underrecognized, poorly diagnosed, and inappropriately treated in primary care settings, which are often the first point of contact with the health provider system. This article highlights the need for changes at the clinical, organizational, and policy levels to create a system of care that can effectively identify, refer, treat, and coordinate the care for these adolescents and their families. JF - Adolescent medicine clinics AU - Huang, Larke N AU - Freed, Rachel AU - Espiritu, Rachele C AD - American Institutes for Research, 1000 Thomas Jefferson Street, Washington, DC 20007, USA. Larke.huang@samhsa.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 453 EP - 467 VL - 17 IS - 2 SN - 1547-3368, 1547-3368 KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Mass Screening -- organization & administration KW - Humans KW - Referral and Consultation KW - Diagnosis, Dual (Psychiatry) KW - Adolescent KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Community Mental Health Services -- organization & administration KW - Mental Disorders -- therapy KW - Primary Health Care -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68595486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adolescent+medicine+clinics&rft.atitle=Co-occurring+disorders+of+adolescents+in+primary+care%3A+closing+the+gaps.&rft.au=Huang%2C+Larke+N%3BFreed%2C+Rachel%3BEspiritu%2C+Rachele+C&rft.aulast=Huang&rft.aufirst=Larke&rft.date=2006-06-01&rft.volume=17&rft.issue=2&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Adolescent+medicine+clinics&rft.issn=15473368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adolescent smokers screened for a nicotine replacement treatment trial: correlates of eligibility and enrollment. AN - 68577731; 16801302 AB - The enrollment process determines the study sample and external validity of clinical trial results; however, few reports describe the process and outcome of screening efforts for smoking cessation studies among adolescents. We describe and evaluate a screening protocol to enroll adolescent smokers for a randomized clinical trial of nicotine replacement therapy. Adolescent smokers obtained the recruitment call-in number (1-800-NO-SMOKE) via media and other advertisements. Trained recruitment staff collected information using an internally developed, targeted telephone screening interview, which was used to determine pre-eligibility for the clinical trial. Correlates of qualification and of study enrollment were determined. Among 1,347 adolescents screened, 329 (24.4%) were eligible to participate in the trial. Light smoking (39.1%) and lack of parental support (14.8%) were the biggest contributors to ineligibility. Eligible adolescents were more likely to be female (66.9% vs. 58.2%, p = .0052) and more likely to be European American (63.5% vs. 52.2%, p = .0003). The higher rates of ineligibility for African Americans and boys were partly explained by lower scores on the Fagerström Test for Nicotine Dependence. Of those eligible to participate in the trial, 159 (48.3%) enrolled. Results underscore the need for screening instruments that are measurement-invariant across ethnicities and gender, and for enrollment strategies that maximize inclusion of eligible participants. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Robinson, Miqun L AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - Clinical Pharmacology and Treatment Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services, MD 21224, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 447 EP - 454 VL - 8 IS - 3 SN - 1462-2203, 1462-2203 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Randomized Controlled Trials as Topic -- standards KW - Adolescent KW - Male KW - Female KW - Smoking -- therapy KW - Nicotine -- therapeutic use KW - Eligibility Determination KW - Adolescent Behavior KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68577731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Adolescent+smokers+screened+for+a+nicotine+replacement+treatment+trial%3A+correlates+of+eligibility+and+enrollment.&rft.au=Robinson%2C+Miqun+L%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Robinson&rft.aufirst=Miqun&rft.date=2006-06-01&rft.volume=8&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of workplace aerosol sampling procedures and their relevance to the assessment of beryllium exposures. AN - 68061622; 16767225 AB - Standardized conventions governing the fractions of airborne particles that can penetrate the human head airways, the thoracic airways and the alveolar spaces have been internationally (although not universally) adopted. Several agencies involved in setting limit values for occupational exposure concentrations have taken these conventions into account when considering the appropriate standard for specific chemicals, in order to ensure the standards are biologically relevant. A convention is selected based on the characteristic health effects, and forms the basis of measurement against the limiting concentration value. In order to assess exposure for comparison to this metric or any other purposes, it is necessary to choose a sampler whose performance matches the convention, and protocols have been developed and used to test sampler performance. Several aerosol sampling devices are available, nominally at least, for each of the conventions. Some considerations important to the sampling of airborne particles containing beryllium with regard to the sampling conventions, the test protocols and sampler performance are discussed. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 598 EP - 604 VL - 8 IS - 6 SN - 1464-0325, 1464-0325 KW - Aerosols KW - 0 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Inhalation Exposure KW - Humans KW - Occupational Exposure KW - Beryllium -- administration & dosage KW - Workplace UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68061622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=A+review+of+workplace+aerosol+sampling+procedures+and+their+relevance+to+the+assessment+of+beryllium+exposures.&rft.au=Harper%2C+Martin&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2006-06-01&rft.volume=8&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States. AN - 68047888; 16294364 AB - To estimate the number of acetaminophen-associated overdoses in the United States and identify possible risk factors for intervention. The investigators obtained estimates of acetaminophen-associated overdoses using different national databases. Two emergency room databases, a hospital discharge database, a national mortality file, and a poison surveillance database were used to identify cases. The FDA's spontaneous reporting system was searched to identify possible root causes for overdoses. Analysis of national databases show that acetaminophen-associated overdoses account for about 56,000 emergency room visits and 26,000 hospitalizations yearly. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. The poison surveillance database showed near-doubling in the number of fatalities associated with acetaminophen from 98 in 1997 to 173 in 2001. AERS data describe a number of possible causes for unintentional acetaminophen-associated overdoses. Each year a substantial numbers of Americans experience intentional and unintentional acetaminophen-associated overdoses that, in severe cases, lead to serious illness and possible death. This summary of a series of analyses highlights the need for strategies to reduce this public health burden. Copyright (c) 2005 John Wiley & Sons, Ltd JF - Pharmacoepidemiology and drug safety AU - Nourjah, Parivash AU - Ahmad, Syed Rizwanuddin AU - Karwoski, Claudia AU - Willy, Mary AD - Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. NOURJAHP@CDER.FDA.GOV Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 398 EP - 405 VL - 15 IS - 6 SN - 1053-8569, 1053-8569 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - United States KW - Hospitals -- statistics & numerical data KW - Humans KW - Aged KW - Child KW - Poison Control Centers -- statistics & numerical data KW - Adult KW - Drug Overdose KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Databases, Factual KW - Emergency Service, Hospital -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Acetaminophen -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68047888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Estimates+of+acetaminophen+%28Paracetomal%29-associated+overdoses+in+the+United+States.&rft.au=Nourjah%2C+Parivash%3BAhmad%2C+Syed+Rizwanuddin%3BKarwoski%2C+Claudia%3BWilly%2C+Mary&rft.aulast=Nourjah&rft.aufirst=Parivash&rft.date=2006-06-01&rft.volume=15&rft.issue=6&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pharmacoepidemiol Drug Saf. 2006 Jun;15(6):406-9 [16739246] Pharmacoepidemiol Drug Saf. 2006 Jun;15(6):410-1 [16739243] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental exposure assessment of pesticides in farmworker homes. AN - 68043971; 16759997 AB - Farmworkers and their families are exposed to pesticides both at work and in their homes. Environmental exposure assessment provides a means to evaluate pesticides in the environment and human contact with these chemicals through identification of sources and routes of exposure. To date, a variety of methods have been used to assess pesticide exposure among farmworker families, mostly focusing on dust and handwipe samples. While many of the methods are similar, differences in the collection, chemical analysis, and statistical analysis, can limit the comparability of results from farmworker studies. This mini-monograph discusses the strategies used to assess pesticide exposures, presents limitations in the available data for farmworkers, and suggests research needs for future studies of pesticide exposure among farmworker families. JF - Environmental health perspectives AU - Hoppin, Jane A AU - Adgate, John L AU - Eberhart, Monty AU - Nishioka, Marcia AU - Ryan, P Barry AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. hoppin1@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 929 EP - 935 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Index Medicus KW - Water Supply -- analysis KW - Humans KW - Food Analysis KW - Food Contamination KW - Population Surveillance KW - Agriculture KW - Environmental Exposure KW - Family KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68043971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+exposure+assessment+of+pesticides+in+farmworker+homes.&rft.au=Hoppin%2C+Jane+A%3BAdgate%2C+John+L%3BEberhart%2C+Monty%3BNishioka%2C+Marcia%3BRyan%2C+P+Barry&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):494-501 [10554151] Environ Health Perspect. 2006 Jun;114(6):943-52 [16759999] J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):521-9 [10554154] J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):145-58 [10791596] J Air Waste Manag Assoc. 2001 Mar;51(3):339-51 [11266098] Environ Health Perspect. 2001 Feb;109(2):145-50 [11266324] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):231-52 [11477521] Bull Environ Contam Toxicol. 2001 Dec;67(6):771-9 [11692189] Bull Environ Contam Toxicol. 2001 Dec;67(6):780-6 [11692190] Bull Environ Contam Toxicol. 2001 Dec;67(6):787-94 [11692191] Environ Health Perspect. 2001 Nov;109(11):1185-91 [11713005] J Expo Anal Environ Epidemiol. 2001 Nov-Dec;11(6):501-9 [11791166] J AOAC Int. 2002 Jan-Feb;85(1):36-43 [11878617] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] Rev Environ Contam Toxicol. 2002;175:1-46 [12206053] J Expo Anal Environ Epidemiol. 2003 Mar;13(2):100-11 [12679790] J Expo Anal Environ Epidemiol. 2003 May;13(3):203-10 [12743614] Environ Health Perspect. 2003 Oct;111(13):1640-8 [14527844] Environ Health Perspect. 2004 Mar;112(3):382-7 [14998757] Annu Rev Public Health. 2004;25:155-97 [15015917] Environ Health Perspect. 2004 Apr;112(5):636-42 [15064174] J Expo Anal Environ Epidemiol. 1991 Jan;1(1):11-30 [1824309] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] Arch Environ Contam Toxicol. 1994 Jan;26(1):47-59 [8110023] Am Ind Hyg Assoc J. 1994 May;55(5):425-32 [7516116] J Expo Anal Environ Epidemiol. 1994 Jan-Mar;4(1):49-63 [7894268] Am J Public Health. 1995 Aug;85(8 Pt 1):1168 [7625524] Environ Health Perspect. 1995 Apr;103 Suppl 3:13-29 [7635107] J Expo Anal Environ Epidemiol. 1995 Jan-Mar;5(1):21-34 [7663147] Arch Environ Contam Toxicol. 1996 Jan;30(1):132-8 [8579382] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] Environ Health Perspect. 1996 Feb;104(2):202-9 [8820589] Bull Environ Contam Toxicol. 1997 May;58(5):681-7 [9115128] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Occup Med. 1997 Apr-Jun;12(2):221-37 [9220483] Environ Health Perspect. 1998 Jan;106(1):9-16 [9417768] Environ Health Perspect. 1998 Jun;106 Suppl 3:827-32 [9646045] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 1998 Nov;106(11):725-31 [9799188] Environ Health Perspect. 1999 Jun;107(6):463-7 [10339446] J Expo Anal Environ Epidemiol. 2005 Jan;15(1):1-5 [15562291] Scand J Work Environ Health. 2005;31 Suppl 1:33-8; discussion 5-7 [16190147] Environ Health Perspect. 2006 Jun;114(6):923-8 [16759996] Environ Health Perspect. 2006 Jun;114(6):936-42 [16759998] J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):513-20 [10554153] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proximity to crops and residential exposure to agricultural herbicides in iowa. AN - 68043272; 16759991 AB - Rural residents can be exposed to agricultural pesticides through the proximity of their homes to crop fields. Previously, we developed a method to create historical crop maps using a geographic information system. The aim of the present study was to determine whether crop maps are useful for predicting levels of crop herbicides in carpet dust samples from residences. From homes of participants in a case-control study of non-Hodgkin lymphoma in Iowa (1998-2000), we collected vacuum cleaner dust and measured 14 herbicides with high use on corn and soybeans in Iowa. Of 112 homes, 58% of residences had crops within 500 m of their home, an intermediate distance for primary drift from aerial and ground applications. Detection rates for herbicides ranged from 0% for metribuzin and cyanazine to 95% for 2,4-dichlorophenoxyacetic acid. Six herbicides used almost exclusively in agriculture were detected in 28% of homes. Detections and concentrations were highest in homes with an active farmer. Increasing acreage of corn and soybean fields within 750 m of homes was associated with significantly elevated odds of detecting agricultural herbicides compared with homes with no crops within 750 m (adjusted odds ratio per 10 acres = 1.06; 95% confidence interval, 1.02-1.11). Herbicide concentrations also increased significantly with increasing acreage within 750 m. We evaluated the distance of crop fields from the home at < 100, 101-250, 251-500, and 501-750 m. Including the crop buffer distance parameters in the model did not significantly improve the fit compared with a model with total acres within 750 m. Our results indicate that crop maps may be a useful method for estimating levels of herbicides in homes from nearby crop fields. JF - Environmental health perspectives AU - Ward, Mary H AU - Lubin, Jay AU - Giglierano, James AU - Colt, Joanne S AU - Wolter, Calvin AU - Bekiroglu, Nural AU - Camann, David AU - Hartge, Patricia AU - Nuckols, John R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. wardm@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 893 EP - 897 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Herbicides KW - 0 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Iowa KW - Crops, Agricultural KW - Environmental Exposure KW - Herbicides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68043272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Proximity+to+crops+and+residential+exposure+to+agricultural+herbicides+in+iowa.&rft.au=Ward%2C+Mary+H%3BLubin%2C+Jay%3BGiglierano%2C+James%3BColt%2C+Joanne+S%3BWolter%2C+Calvin%3BBekiroglu%2C+Nural%3BCamann%2C+David%3BHartge%2C+Patricia%3BNuckols%2C+John+R&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Jan;108(1):5-12 [10622770] J Occup Environ Hyg. 2005 Jul;2(7):357-67 [16020099] Epidemiology. 2001 Mar;12(2):148-56 [11246574] J Expo Anal Environ Epidemiol. 2001 Jan-Feb;11(1):56-65 [11246803] J Environ Qual. 2001 May-Jun;30(3):697-701 [11401259] Environ Health Perspect. 2002 Mar;110(3):319-24 [11882484] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] Environ Health Perspect. 2002 Dec;110(12):1175-84 [12460795] Environ Health Perspect. 2002 Dec;110(12):A787-92 [12460819] Environ Health Perspect. 2003 Oct;111(13):1582-9 [14527836] Environ Sci Technol. 2003 Oct 15;37(20):4543-53 [14594359] J Expo Anal Environ Epidemiol. 2004 Jan;14(1):74-83 [14726946] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Epidemiology. 2005 Jul;16(4):542-7 [15951673] Environ Res. 2000 Nov;84(3):290-302 [11097803] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. AN - 68021461; 16497704 AB - The field of cancer epigenetics has received much attention in recent years. However, the relationship of cancer epigenetics with cancer etiology is not clear. Recent studies suggest the involvement of altered DNA methylation and histone modifications in the emergence of epigenetically reprogrammed cells with specific tumor-related phenotypes at premalignant stages of tumor development. In this study, we used a methyl-deficient model of rodent hepatocarcinogenesis to examine the roles of DNA, histone H3 lysine 9 and histone H4 lysine 20 methylation, and the level of the expression of Suv39h1 and Suv4-20h2 histone methyltransferases in the carcinogenic process. We demonstrated that the development of liver tumors was characterized by progressive demethylation of DNA repeats, decrease in histone H4 lysine 20 trimethylation, and a gradual decrease in the expression of Suv4-20h2 histone methyltransferase. A prominent increase in the trimethylation of histone H3 lysine 9 and in the expression of Suv39h1 histone methyltransferase was observed in preneoplastic nodules and liver tumors indicating the promotional role of these epigenetic alterations at later stages of carcinogenesis. The appearance of tumor-specific epigenetic alterations (demethylation of repetitive elements, loss of histone H4 lysine 20 trimethylation, altered expression of Suv4-20h2 and Suv39h1 histone methyltransferases) at preneoplastic stages of hepatocarcinogenesis provides experimental support for the epigenetic hypothesis of tumorigenesis that considers stress-induced epigenetic reprogramming of the cell as an important prerequisite to succeeding mutations. JF - Carcinogenesis AU - Pogribny, Igor P AU - Ross, Sharon A AU - Tryndyak, Volodymyr P AU - Pogribna, Marta AU - Poirier, Lionel A AU - Karpinets, Tatiana V AD - National Center for Toxicological Research, Jefferson, AR 72078, National Cancer Institute, Bethesda, MD 20892 and University of Tennessee, Knoxville, TN 37996, USA. ipogribny@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1180 EP - 1186 VL - 27 IS - 6 SN - 0143-3334, 0143-3334 KW - Histones KW - 0 KW - Repressor Proteins KW - Suv39h1 protein, mouse KW - EC 2.1.1. KW - Suv39h1 protein, rat KW - Methyltransferases KW - EC 2.1.1.- KW - Protein Methyltransferases KW - histone methyltransferase KW - Suv4-20h2 protein, rat KW - EC 2.1.1.125 KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Long Interspersed Nucleotide Elements KW - DNA Methylation KW - Epigenesis, Genetic KW - Mutation KW - Methylation KW - Male KW - Repressor Proteins -- biosynthesis KW - Liver Neoplasms -- metabolism KW - Histones -- metabolism KW - Histones -- chemistry KW - Methyltransferases -- chemistry KW - Methyltransferases -- biosynthesis KW - Histone-Lysine N-Methyltransferase -- chemistry KW - Repressor Proteins -- chemistry KW - Histone-Lysine N-Methyltransferase -- metabolism KW - Histone-Lysine N-Methyltransferase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68021461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Histone+H3+lysine+9+and+H4+lysine+20+trimethylation+and+the+expression+of+Suv4-20h2+and+Suv-39h1+histone+methyltransferases+in+hepatocarcinogenesis+induced+by+methyl+deficiency+in+rats.&rft.au=Pogribny%2C+Igor+P%3BRoss%2C+Sharon+A%3BTryndyak%2C+Volodymyr+P%3BPogribna%2C+Marta%3BPoirier%2C+Lionel+A%3BKarpinets%2C+Tatiana+V&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2006-06-01&rft.volume=27&rft.issue=6&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transfusion-related acute lung injury. AN - 68014027; 16728851 JF - The American journal of nursing AU - Knippen, Maureen A AD - Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration in Rockville, MD, USA. maureen.knippen@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 61 EP - 64 VL - 106 IS - 6 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - United States KW - Humans KW - Rare Diseases KW - United States Food and Drug Administration KW - Histocompatibility Testing KW - Adverse Drug Reaction Reporting Systems KW - Risk Factors KW - Adult KW - Practice Guidelines as Topic KW - Nurse's Role KW - Middle Aged KW - Early Diagnosis KW - Time Factors KW - Female KW - Respiratory Distress Syndrome, Adult -- diagnosis KW - Blood Transfusion -- adverse effects KW - Respiratory Distress Syndrome, Adult -- therapy KW - Transplantation, Homologous -- adverse effects KW - Blood Transfusion -- nursing KW - Transplantation, Homologous -- nursing KW - Respiratory Distress Syndrome, Adult -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68014027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Transfusion-related+acute+lung+injury.&rft.au=Knippen%2C+Maureen+A&rft.aulast=Knippen&rft.aufirst=Maureen&rft.date=2006-06-01&rft.volume=106&rft.issue=6&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-23 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. AN - 68004871; 16716128 AB - To analyze the disproportionality of reporting of hyperprolactinemia, galactorrhea, and pituitary tumors with seven widely used antipsychotic drugs. Retrospective pharmacovigilance study. United States Food and Drug Administration's Adverse Event Reporting System (AERS) database. We initially identified higher-than-expected postmarketing reports of pituitary tumors associated with risperidone, a potent dopamine D2-receptor antagonist antipsychotic, by analyzing reporting patterns of these tumors in the AERS database. To further examine this association, we analyzed disproportionate reporting patterns of pituitary tumor reports for seven antipsychotics with different affinities for blocking D2 receptors: aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, and haloperidol. To conduct both of these analyses, we used the Multi-item Gamma Poisson Shrinker (MGPS) data mining algorithm applied to the AERS database. The MGPS uses a Bayesian model to calculate adjusted observed:expected ratios of drug-adverse event associations (Empiric Bayes Geometric Mean [EBGM] values) in huge drug safety databases. The higher the adjusted reporting ratio, or EBGM value, the greater the strength of the association between a drug and an adverse event. Risperidone had the highest adjusted reporting ratios for hyperprolactinemia (EBGM 34.9, 90% confidence interval [CI] 32.8-37.1]), galactorrhea (EBGM 19.9, 90% CI 18.6-21.4), and pituitary tumor (EBGM 18.7, 90% CI 14.9-23.3) among the seven antipsychotics, and one of the highest scores for all drugs in the AERS database. Some tumors were associated with visual field defects, hemorrhage, convulsions, surgery, and severe (>10-fold) prolactin elevations. The EBGM values for risperidone for these adverse events were higher in women, but high EBGM values for these events were also seen in men and children. Moreover, the rank order of the EBGM values for pituitary tumors corresponded to the affinities of these seven drugs for D2 receptors. Treatment with potent D2-receptor antagonists, such as risperidone, may be associated with pituitary tumors. These findings are consistent with animal (mice) studies and raise the need for clinical awareness and longitudinal studies. JF - Pharmacotherapy AU - Szarfman, Ana AU - Tonning, Joseph M AU - Levine, Jonathan G AU - Doraiswamy, P Murali AD - Office of Pharmacoepidemiology and Statistical Sciences, Immediate Office, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. szarfman@cder.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 748 EP - 758 VL - 26 IS - 6 SN - 0277-0008, 0277-0008 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Piperazines KW - Quinolones KW - Thiazoles KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - ziprasidone KW - 6UKA5VEJ6X KW - Aripiprazole KW - 82VFR53I78 KW - Clozapine KW - J60AR2IKIC KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - United States KW - Haloperidol -- adverse effects KW - Quinolones -- adverse effects KW - Galactorrhea -- chemically induced KW - Sex Factors KW - Humans KW - Retrospective Studies KW - Child KW - Thiazoles -- adverse effects KW - Piperazines -- adverse effects KW - Clozapine -- adverse effects KW - United States Food and Drug Administration KW - Dibenzothiazepines -- adverse effects KW - Benzodiazepines -- adverse effects KW - Gynecomastia -- chemically induced KW - Risperidone -- adverse effects KW - Hyperprolactinemia -- chemically induced KW - Adolescent KW - Amenorrhea -- chemically induced KW - Male KW - Female KW - Pituitary Neoplasms -- chemically induced KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68004871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Atypical+antipsychotics+and+pituitary+tumors%3A+a+pharmacovigilance+study.&rft.au=Szarfman%2C+Ana%3BTonning%2C+Joseph+M%3BLevine%2C+Jonathan+G%3BDoraiswamy%2C+P+Murali&rft.aulast=Szarfman&rft.aufirst=Ana&rft.date=2006-06-01&rft.volume=26&rft.issue=6&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pilot measurements of ELF contact currents in some electric utility occupations. AN - 67995704; 16718950 AB - Contact currents from touching objects with different voltages can produce electric fields within the body that produce neurological and other biological effects. To begin measuring these exposures among electric utility workers, a new contact current meter (CCM) was tested in a pilot study at Southern California Edison. The CCM was worn for 82 full-shift measurements by 76 volunteers from eight occupations who did not work directly with energized electrical equipment. The volunteers were exposed to an average of 285.8 contact current events above the meter's 1-microA threshold, but most of these were electrostatic spark discharges. Fourteen employees experienced an average of 135.1 contact currents events whose primary frequency was 60 Hz. Using a circuit model of the human body, the average contact currents going from arm to arm was 9.8 microA (maximum = 178.0 microA), and the average going down the torso was 25.5 microA (maximum = 662.0). The maximum exposures were experienced by a technical support employee working in a substation. All measurements in this pilot study were below the 3000 microA maximum permissible exposure for contact currents set by the Institute of Electrical and Electronic Engineers (IEEE). Combining these current measurements with the results of high-resolution dosimetry, the internal electric fields averaged an estimated 1.7 mV/m in the heart (maximum = 21.0 mV/m), and 1.9 mV/m in the hematopoietic bone marrow in the torso (maximum = 56.5 mV/m). These internal electric fields from contact currents are below the basic restriction of 943 mV/m in the IEEE exposure standards but are above 1 mV/m, a level where biological effects have been often reported in laboratory studies. Safety concerns limited the measurements to de-energized equipment, so we did not obtain data on work in energized high-voltage environments, the most likely sources of high contact currents. This pilot study identified other improvements to the contact current meter that would make it better able to measure exposures in future health studies. JF - Journal of occupational and environmental hygiene AU - Bowman, Joseph AU - Niple, John AU - Kavet, Rob AD - NIOSH Physical Hazards Team, Engineering and Physical Hazards Branch, National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. jdb0@cdc.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 323 EP - 333 VL - 3 IS - 6 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - California KW - Maximum Allowable Concentration KW - Humans KW - Body Burden KW - Pilot Projects KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Electromagnetic Fields KW - Electric Conductivity KW - Occupational Exposure -- standards KW - Electrophysiology -- standards KW - Electrophysiology -- instrumentation KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67995704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Pilot+measurements+of+ELF+contact+currents+in+some+electric+utility+occupations.&rft.au=Bowman%2C+Joseph%3BNiple%2C+John%3BKavet%2C+Rob&rft.aulast=Bowman&rft.aufirst=Joseph&rft.date=2006-06-01&rft.volume=3&rft.issue=6&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-05-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Occup Environ Hyg. 2007 Jul;4(7):D65-6 [17497395] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Focusing in on dose reduction: the FDA perspective. AN - 67994405; 16714664 JF - AJR. American journal of roentgenology AU - Barr, Helen J AU - Ohlhaber, Thomas AU - Finder, Charles AD - Food and Drug Administration, Center for Devices and Radiological Health, Division of Mammography Quality and Radiation Programs, 1350 Piccard Dr., Rockville, MD 20850, USA. helen.barr@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1716 EP - 1717 VL - 186 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Radiation Dosage KW - United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67994405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AJR.+American+journal+of+roentgenology&rft.atitle=Focusing+in+on+dose+reduction%3A+the+FDA+perspective.&rft.au=Barr%2C+Helen+J%3BOhlhaber%2C+Thomas%3BFinder%2C+Charles&rft.aulast=Barr&rft.aufirst=Helen&rft.date=2006-06-01&rft.volume=186&rft.issue=6&rft.spage=1716&rft.isbn=&rft.btitle=&rft.title=AJR.+American+journal+of+roentgenology&rft.issn=1546-3141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. AN - 67980526; 16700620 AB - The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two years. Novel approaches for brain tumor therapy are needed. Recently, targeted therapies have emerged as promising modality for cancer targeting. We have discovered that high affinity plasma membrane receptor for interleukin-13 (IL-13), an immune regulatory cytokine, is over-expressed in 60-80% of malignant brain tumors. To target these IL-13R, we generated a chimeric fusion protein, composed of human IL-13 and mutated Pseudomonas exotoxin (PE), termed IL-13 cytotoxin (IL13-PE), and tested its cytotoxicity to IL-13R-expressing GBM cells. IL-13 cytotoxin was highly potent and selective in killing IL-13R-expressing GBM cells. In contrast, normal cells including brain, immune, and endothelial cells were generally not affected by this cytotoxin due to no or low expression of IL-13R. In vivo pre-clinical studies for safety and toxicity were also performed in mice, rats, and monkeys, and IL-13 cytotoxin was found to be well tolerated by both systemic and intracerebral administrations. IL-13 cytotoxin was found to mediate remarkable efficacy in animal models of human brain tumors. Encouraged by these pre-clinical studies, four Phase 1/2 clinical trials in adult patients with recurrent malignant glioma have been completed. These clinical trials involved convection-enhanced delivery (CED) of IL-13 cytotoxin either intratumoral or intraparenchymal after resection of tumor. CED is a novel loco-regional drug delivery method for intracranial tumors that relies on a continuous pressure gradient to distribute drug into interstitial space. This route of IL-13 cytotoxin administration appears to be very well tolerated and have a good risk-benefit profile. Most recently, a randomized controlled Phase 3 clinical trial (PRECISE) with intraparenchymal IL-13 cytotoxin administration was completed and subjects are being monitored for safety and survival. JF - Technology in cancer research & treatment AU - Kioi, Mitomu AU - Husain, Syed R AU - Croteau, David AU - Kunwar, Sandeep AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 239 EP - 250 VL - 5 IS - 3 SN - 1533-0346, 1533-0346 KW - Exotoxins KW - 0 KW - IL13-PE38QQR KW - IL13RA1 protein, human KW - Interleukin-13 KW - Interleukin-13 Receptor alpha1 Subunit KW - Receptors, Interleukin KW - Receptors, Interleukin-13 KW - Index Medicus KW - Animals KW - Receptors, Interleukin -- metabolism KW - Humans KW - Clinical Trials as Topic KW - Convection KW - Interleukin-13 -- administration & dosage KW - Drug Delivery Systems KW - Exotoxins -- administration & dosage KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Interleukin-13 -- therapeutic use KW - Brain Neoplasms -- metabolism KW - Exotoxins -- toxicity KW - Glioma -- metabolism KW - Exotoxins -- therapeutic use KW - Interleukin-13 -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67980526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technology+in+cancer+research+%26+treatment&rft.atitle=Convection-enhanced+delivery+of+interleukin-13+receptor-directed+cytotoxin+for+malignant+glioma+therapy.&rft.au=Kioi%2C+Mitomu%3BHusain%2C+Syed+R%3BCroteau%2C+David%3BKunwar%2C+Sandeep%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2006-06-01&rft.volume=5&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Technology+in+cancer+research+%26+treatment&rft.issn=15330346&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Bone marrow dose estimates from work-related medical x-ray examinations given between 1943 and 1966 for personnel from five U.S. nuclear facilities. AN - 67965412; 16691102 AB - Inclusion of dose from work-related medical x-ray examinations with occupational external dose in an epidemiological study may reduce misclassification of exposures and provide more accurate assessment of leukemia risk from occupational exposure to ionizing radiation. In a multi-site leukemia case-control study, annual bone marrow doses due to work-related x-ray examinations given between 1943 and 1966 were estimated for cases and controls employed at five nuclear facilities. Only active bone marrow dose from photofluorographic chest and routine lumbar spine x rays were included. Bone marrow dose assigned for a single exposure ranged from 1.0 to 1.4 mGy. Mean and median cumulative bone marrow doses for each of the five sites from work-related x-ray examinations ranged from 2.0 to 14 mGy and 2.1 to 8.8 mGy, respectively. Results suggest that bone marrow dose from work-related photofluorographic and lumbar spine x-ray examinations given during the time period of this study may be significant compared to occupational bone marrow dose. JF - Health physics AU - Anderson, Jeri L AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, PHS/DHHS, 4676 Columbia Pkwy, Mail Stop R-44, Cincinnati, OH 45226, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 544 EP - 553 VL - 90 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Risk Factors KW - Humans KW - Body Burden KW - United States -- epidemiology KW - Bone Marrow KW - Radiation Monitoring -- methods KW - Nuclear Reactors -- statistics & numerical data KW - Power Plants -- statistics & numerical data KW - Radiography -- statistics & numerical data KW - Risk Assessment -- methods KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67965412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Bone+marrow+dose+estimates+from+work-related+medical+x-ray+examinations+given+between+1943+and+1966+for+personnel+from+five+U.S.+nuclear+facilities.&rft.au=Anderson%2C+Jeri+L%3BDaniels%2C+Robert+D&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2006-06-01&rft.volume=90&rft.issue=6&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-08 N1 - Date created - 2006-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of Dithiocarbamates in Agricultural Products Circulated in Korea AN - 21292726; 12537009 AB - To revise the dithiocarbamates residue analysis method and survey the residues in agricultural products that were treated with these fungicides in Korea, we purchased 20 types of foodstuffs (rice, potato, cabbage, apple etc.) from markets in five major cities. 236 samples of the purchased foodstuffs were then analyzed for the presence of dithiocarbamates by HPLC/UV and HPLC/APCI-MS. The R super(2), LOD and LOQ in the range of 0.5-107.3 mg/L were as follows: DCC: y=174.34x+18.315, R super(2)=0.9999, 0.01 mg/L, and 0.04 mg/L; EBDC: y=227.38x-14.715, R super(2)=1.0000, 0.01 mg/L and 0.02 mg/L; PBDC: y=38.46x-21.412, R super(2)=0.9999, 0.04 mg/L, and 0.1 mg/L; ETU: y=52.752x-4.4819, R super(2)=0.9-998, 0.02 mg/L and 0.03 mg/L; PTU: y=128.28x+4.4624, R super(2)=0.9998, 0.02 mg/L, and 0.04 mg/L. The levels of DDC, EBDC, PBDC, ETU and PTU in 20 agricultural products fortified to 10.0-107.3 mg/L ranged from 61.7-117.5%, 65.3-110.1%, 61.5-109.6%, 69.3-116.3% and 70.2-97.2%, respectively. Overall, dithiocarbamates were detected in 100 samples and the detection ratio was 42.4%. Among these, only 3 samples (1.3%) of Lycii fructus had residue levels that were above the action limits, while the remaining samples (233 samples) contained levels of dithiocarbamates below the detection limit or below the Korea MRLs (Maximum Residue Limits). JF - Korean Journal of Food Science and Technology AU - Kim, H-Y AU - Choi, H-J AU - Eom, J-Y AU - Seo, E-C AU - Choi, S-H AU - Cheong, S-Y AU - Lee, H-J AU - Choi, J-C AD - Gyeongin Regional Korea Food and Drug Administration, Incheon 402-835, Korea, chjatu@kfda.go.kr Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1 EP - 7 VL - 38 IS - 3 SN - 0367-6293, 0367-6293 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Solanum tuberosum KW - Food KW - Agricultural products KW - Fungicides KW - Malus KW - Oryza sativa KW - Brassica KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21292726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Determination+of+Dithiocarbamates+in+Agricultural+Products+Circulated+in+Korea&rft.au=Kim%2C+H-Y%3BChoi%2C+H-J%3BEom%2C+J-Y%3BSeo%2C+E-C%3BChoi%2C+S-H%3BCheong%2C+S-Y%3BLee%2C+H-J%3BChoi%2C+J-C&rft.aulast=Kim&rft.aufirst=H-Y&rft.date=2006-06-01&rft.volume=38&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Food; Fungicides; Agricultural products; Solanum tuberosum; Oryza sativa; Malus; Brassica ER - TY - JOUR T1 - Steady State Pharmacokinetics of Oral Treatment with 13-cis-Retinoic Acid or all-trans-Retinoic Acid in Male and Female Adult Rats AN - 21035317; 6881562 AB - Male and female Sprague-Dawley rats were orally gavaged with 13-cis-retinoic acid (7.5 or 15 mg-kg) or all-trans-retinoic acid (10 or 15 mg-kg) for 7 consecutive days. Blood was collected out to 8 hr after the last gavage on day 7. HPLC serum concentrations of 13-cis-retinoic acid, all-trans-retinoic acid, and 13-cis-4-oxo-retinoic acid were subjected to model independent pharmacokinetic analyses. Peak serum levels of 563 to 1640 ng-ml were observed for rats treated with 13-cis-retinoic acid at 1.5-2 hr after gavage. Peak serum levels of 183 to 267 ng-ml at 1.5 hr after gavage were observed for all-trans-retinoic acids. The elimination half-life of 13-cis-retinoic acid was about 1.5 hr while the elimination half-life of all-trans-retinoic acid was slightly longer. There were no sex differences for any parameter. Serum levels resulting from the 7.5 mg-kg 13-cis-retinoic acid were similar to those of human Accutane super( registered ) users. JF - Basic & Clinical Pharmacology & Toxicology AU - Ferguson, Sherry A AU - Siitonen, Paul H AU - Cisneros, FJavier AU - Gough, Bobby AU - Young, John F AD - Division of Neurotoxicology, sferguson@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 582 EP - 587 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 98 IS - 6 SN - 1742-7835, 1742-7835 KW - Toxicology Abstracts KW - Serum levels KW - High-performance liquid chromatography KW - Blood KW - Retinoic acid KW - Sex differences KW - Pharmacokinetics KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.atitle=Steady+State+Pharmacokinetics+of+Oral+Treatment+with+13-cis-Retinoic+Acid+or+all-trans-Retinoic+Acid+in+Male+and+Female+Adult+Rats&rft.au=Ferguson%2C+Sherry+A%3BSiitonen%2C+Paul+H%3BCisneros%2C+FJavier%3BGough%2C+Bobby%3BYoung%2C+John+F&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2006-06-01&rft.volume=98&rft.issue=6&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.issn=17427835&rft_id=info:doi/10.1111%2Fj.1742-7843.2006.pto_359.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Tables, 1; references, 31. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Serum levels; Blood; Retinoic acid; Sex differences; Pharmacokinetics; Models DO - http://dx.doi.org/10.1111/j.1742-7843.2006.pto_359.x ER - TY - JOUR T1 - The advisory process for anticancer drug regulation: a global perspective AN - 20246829; 6945035 AB - PURPOSE: This paper summarizes the role of external advisors in oncology drug development and regulation from a global perspective. DESIGN: Recently, representatives from the United States Food and Drug Administration, European Medicines Agency, the Japanese Pharmaceuticals and Medical Devices Agency, the Australian Therapeutic Goods Administration and Health Canada held a meeting in conjunction with the American Society of Clinical Oncology meeting. The role of external advisors in oncology drug development and regulation in each of these jurisdictions was presented and discussed. RESULTS: All regulatory bodies described have experience with two forms of outside expertise: advice from individual experts and advice from a group of experts assembled as an advisory group. Regulatory jurisdictions use individual experts variably. In some regions, individual experts provide advice based on knowledge and experience during the drug development phase or in the planning phase for the submission of a drug registration package. In other regions, these individuals serve as external evaluators with the primary responsibility for the review of a clinical trials package submitted for drug registration. Advisory boards have been formalized in all jurisdictions discussed. Advisory boards have a role in discussing specific applications as well as broad policy issues. A common theme is a composition of a core panel of experts with augmentation by additional expertise as needed for consideration of specific scientific questions. In all jurisdictions, advisory board recommendations are not binding on the regulatory body. CONCLUSIONS: Global oncology drug development and registration involves the use of experts by regulatory authorities. The types of experts needed, the expert's role and the transparency of the advisory process reflect the individual needs in different regions. JF - Annals of Oncology AU - Farrell, A T AU - Papadouli, I AU - Hori, A AU - Harczy, M AU - Harrison, B AU - Asakura, W AU - Marty, M AU - Dagher, R AU - Pazdur, R AD - United States Food and Drug Administration, Center for Drug Evaluation and Research Office of New Drugs, Office of Oncology Drug Products, Division of Drug Oncology Products, Silver Spring, MD, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 889 EP - 896 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 17 IS - 6 SN - 0923-7534, 0923-7534 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Pharmaceuticals KW - Drug development KW - Oncology KW - Antitumor agents KW - Clinical trials KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20246829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=The+advisory+process+for+anticancer+drug+regulation%3A+a+global+perspective&rft.au=Farrell%2C+A+T%3BPapadouli%2C+I%3BHori%2C+A%3BHarczy%2C+M%3BHarrison%2C+B%3BAsakura%2C+W%3BMarty%2C+M%3BDagher%2C+R%3BPazdur%2C+R&rft.aulast=Farrell&rft.aufirst=A&rft.date=2006-06-01&rft.volume=17&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Pharmaceuticals; Oncology; Drug development; Clinical trials; Antitumor agents ER - TY - JOUR T1 - MicroRNAs and cell differentiation in mammalian development AN - 20205879; 7596922 AB - MicroRNAs (miRNAs) are a group of recently discovered small RNAs produced by the cell using a unique process, involving RNA polymerase II, Microprocessor protein complex, and the RNAase III/Dicer endonuclease complex, and subsequently sequestered in an miRNA ribonucleoprotein complex. The biological functions of miRNAs depend on their ability to silence gene expression, primarily via degradation of the target mRNA and/or translational suppression, mediated by the RNA-induced silencing complex (RISC). First discovered in Caenorhabditis elegans (lin-4), miRNAs have now been identified in a wide array of organisms, including plants, zebrafish, Drosophila, and mammals. The expression of miRNAs in multicellular organisms exhibits spatiotemporal, and tissue- and cell-specificity, suggesting their involvement in tissue morphogenesis and cell differentiation. More than 200 miRNAs have been identified or predicted in mammalian cells. Recent studies have demonstrated the importance of miRNAs in embryonic stem cell differentiation, limb development, adipogenesis, myogenesis, angiogenesis and hematopoiesis, neurogenesis, and epithelial morphogenesis. Overexpression (gain-of-function) and inactivation (loss-of-function) are currently the primary approaches to studying miRNA functions. Another family of small RNAs related to miRNAs is the small interfering RNAs (siRNAs), generated by Dicer from long double-stranded RNAs (dsRNAs), and produced from an induced transgene, a viral intruder, or a rogue genetic element. siRNAs silence genes via either mRNA degradation, using the RISC, or DNA methylation. siRNAs are actively being applied in basic, functional genetic studies, particularly in the generation of gene knockdown animals, as well as in gene knockdown studies of cultured cells. These studies have provided invaluable information on the specific function(s) of individual genes. siRNA technology also presents exciting potential as a therapeutic approach in disease prevention and treatment, as suggested by a recent study targeting apolipoprotein B (ApoB) in primates. Further elucidation of how miRNAs and other small RNAs interact with known and yet-to-be identified gene regulatory pathways in the cell should provide us with a more in-depth understanding of the mechanisms regulating cellular function and differentiation, and facilitate the application of small RNA technology in disease control and treatment. Birth Defects Research (Part C) 78:140-149, 2006. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Song, Lin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch of the National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, tuanr@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 140 EP - 149 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 78 IS - 2 SN - 1542-975X, 1542-975X KW - Zebra danio KW - Zebra fish KW - Entomology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - myogenesis KW - Translation KW - Apolipoprotein B KW - Double-stranded RNA KW - Morphogenesis KW - Disease control KW - Angiogenesis KW - Gene expression KW - Differentiation KW - DNA-directed RNA polymerase KW - Stem cells KW - Neurogenesis KW - Mammalian cells KW - Embryo cells KW - Caenorhabditis elegans KW - DNA methylation KW - Congenital defects KW - RNA-induced silencing complex KW - Endonuclease KW - adipogenesis KW - miRNA KW - Transgenes KW - Primates KW - Danio rerio KW - Intruder KW - Limbs KW - siRNA KW - Ribonucleoproteins KW - Hemopoiesis KW - Drosophila KW - Gene silencing KW - W 30925:Genetic Engineering KW - Z 05360:Genetics and Evolution KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20205879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=MicroRNAs+and+cell+differentiation+in+mammalian+development&rft.au=Song%2C+Lin%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-06-01&rft.volume=78&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - myogenesis; Translation; Apolipoprotein B; Double-stranded RNA; Morphogenesis; Angiogenesis; Disease control; Gene expression; Differentiation; Neurogenesis; Stem cells; DNA-directed RNA polymerase; Embryo cells; Mammalian cells; DNA methylation; Congenital defects; RNA-induced silencing complex; adipogenesis; Endonuclease; Transgenes; miRNA; Intruder; Limbs; siRNA; Ribonucleoproteins; Hemopoiesis; Gene silencing; Danio rerio; Caenorhabditis elegans; Primates; Drosophila DO - http://dx.doi.org/10.1002/bdrc.20069 ER - TY - JOUR T1 - Glucocorticoids Promote Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells by Enhancing Expression of Cartilage Extracellular Matrix Genes AN - 19986137; 6999317 AB - In the adult human, mesenchymal stem cells (hMSCs) resident in the bone marrow retain the capacity to proliferate and differentiate along multiple connective tissue lineages, including cartilage. Glucocorticoids (GCs) are required for chondrogenic differentiation of hMSCs in vitro; however, the exact role of GCs in this process is not known. In this study, we examined the effects of dexamethasone (DEX) on chondrogenic differentiation of hMSCs in the presence or absence of DEX, transforming growth factor-{szligbeta} (TGF-{szligbeta}), or DEX plus TGF-{szligbeta}. GC treatment upregulated gene expression of cartilage matrix components aggrecan, dermatopontin, and collagen type XI; enhanced TGF-{szligbeta}-mediated upregulation of collagen type II and cartilage oligomeric matrix protein; and increased aggrecan and collagen type II production as well as cartilage matrix-sulfated proteoglycans as assessed by immunohistochemistry and alcian blue staining. Inclusion of an antagonist of GCs inhibited expression of chondrogenic differentiation markers, suggesting that the GC effects during chondrogenesis are mediated by the GC receptor (GR). Steady levels of the major active form of GR, GR alpha , were detected in both undifferentiated and differentiating hMSCs, whereas the dominant-negative isoform GR{szligbeta}, present at low levels in undifferentiated hMSCs, was downregulated during chondrogenesis. In the presence of DEX and TGF-{szligbeta}, expression of a collagen type II gene promoter luciferase reporter construct in hMSCs was upregulated. However, coexpression of GR{szligbeta} dramatically inhibited promoter activity, suggesting that GR alpha is required for GC-mediated modulation of chondrogenesis and that GCs may play an important role in the maintenance of cartilage homeostasis. JF - Stem Cells AU - Derfoul, Assia AU - Perkins, Geraldine L AU - Hall, David J AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, Cartilage Genetics Group, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1487 EP - 1495 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Calcium & Calcified Tissue Abstracts KW - Cartilage oligomeric matrix protein KW - Dexamethasone KW - Connective tissues KW - Cartilage KW - Bone marrow KW - Glucocorticoids KW - Proteoglycans KW - Promoters KW - Stem cells KW - Extracellular matrix KW - Collagen (type II) KW - aggrecan KW - Mesenchyme KW - Immunohistochemistry KW - Chondrogenesis KW - G 07880:Human Genetics KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Glucocorticoids+Promote+Chondrogenic+Differentiation+of+Adult+Human+Mesenchymal+Stem+Cells+by+Enhancing+Expression+of+Cartilage+Extracellular+Matrix+Genes&rft.au=Derfoul%2C+Assia%3BPerkins%2C+Geraldine+L%3BHall%2C+David+J%3BTuan%2C+Rocky+S&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Cartilage oligomeric matrix protein; Connective tissues; Cartilage; Bone marrow; Glucocorticoids; Proteoglycans; Promoters; Stem cells; Extracellular matrix; Collagen (type II); Mesenchyme; aggrecan; Immunohistochemistry; Chondrogenesis ER - TY - JOUR T1 - In vitro antimicrobial susceptibility, genetic diversity and prevalence of UDP-glucose 4-epimerase (galE) gene in Campylobacter coli and Campylobacter jejuni from Turkey production facilities AN - 19980911; 6742834 AB - This study evaluated the genetic diversity of multi-drug resistant Campylobacter jejuni (n=44) and C. coli (n=30) isolated from 18 turkey houses. Antimicrobial resistances to ampicillin, ciprofloxacin and nalidixic acid were higher (P<0.05) in C. coli than in C. jejuni strains. PCR analysis indicated that 82% of total isolates tested, including 91% of C. jejuni and 70% of C. coli tested positive for a 496-bp UDP-glucose 4-epimerase (galE) gene. The diversity of isolates was mapped by antibiogram, SmaI-PFGE and flaA-RFLP typing methods using the discriminatory index (DI). RFLP was more suitable in discriminating C. coli (DI=0.895) than PFGE (DI=0.816) or antibiogram profile (DI=0.552), while either PFGE (DI=0.941) or RFLP (DI=0.942) could be used in discriminating C. jejuni strains. The combined PFGE and antibiogram dendrogram had the highest DI for both C. coli (0.910) and C. jejuni (0.968), suggesting that a combination of typing methods is more useful in examining the diverse Campylobacter population on turkey farms. JF - Food Microbiology AU - Nayak, R AU - Stewart, T AU - Nawaz, M AU - Cerniglia, C AD - National Center for Toxicological Research, Division of Microbiology, 3900 NCTR Road, Jefferson, AR 72079, USA, rnayak@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 379 EP - 392 VL - 23 IS - 4 SN - 0740-0020, 0740-0020 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Poultry KW - Houses KW - Farms KW - Campylobacter coli KW - Genetic diversity KW - Ampicillin KW - Microbial contamination KW - Antimicrobial agents KW - Ciprofloxacin KW - Typing KW - Food processing industry KW - Campylobacter jejuni KW - Nalidixic acid KW - Polymerase chain reaction KW - Multidrug resistance KW - Antibiotic resistance KW - J 02310:Genetics & Taxonomy KW - A 01064:Microbial resistance KW - G 07770:Bacteria KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=In+vitro+antimicrobial+susceptibility%2C+genetic+diversity+and+prevalence+of+UDP-glucose+4-epimerase+%28galE%29+gene+in+Campylobacter+coli+and+Campylobacter+jejuni+from+Turkey+production+facilities&rft.au=Nayak%2C+R%3BStewart%2C+T%3BNawaz%2C+M%3BCerniglia%2C+C&rft.aulast=Nayak&rft.aufirst=R&rft.date=2006-06-01&rft.volume=23&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2005.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ciprofloxacin; Houses; Farms; Typing; Nalidixic acid; Ampicillin; Polymerase chain reaction; Genetic diversity; Multidrug resistance; Antibiotic resistance; Antimicrobial agents; Poultry; Food processing industry; Microbial contamination; Campylobacter jejuni; Campylobacter coli DO - http://dx.doi.org/10.1016/j.fm.2005.04.007 ER - TY - JOUR T1 - Using PCR amplification to increase the confidence level of Salmonella typhimurium DNA microarray chip hybridization AN - 19969191; 6822923 AB - In order to design and validate a method to identify virulence genes of Salmonella typhimurium using DNA microarray, a protocol was developed to label the isolated bacterial DNA directly and to use PCR amplification of limited numbers of genes to validate the hybridization signals. Therefore, a DNA microarray chip of 71 virulence genes of S. typhimurium was developed and evaluated using 10 isolates. Each gene was represented by 65 bp oligonucleotide probes (oligoprobes) and immobilized on the surface of chemically modified slides. Whole DNA genomes were digested with Hinf1 and Sau3AI, labeled with a fluorescent tag of Cy3 and then hybridized. The presence of virulence genes in 10 strains of S. typhimurium was established by measuring a fluorescent signal above the background noise of the chip. PCR amplification of 10 genes (orgA, ORF319, ttrB, rmbA, misL, spi4F, spi4H, spi4N, rRNA, and purR) of S. typhimurium was used as a standard to verify the confidence level of the DNA microarray chip. In conclusion, using PCR amplification to increase the confidence level of the microarray hybridization data was successful. JF - Molecular and Cellular Probes AU - Courtney, Shannon AU - Mossoba, Miriam E AU - Hammack, Thomas S AU - Keys, Christine AU - Al-Khaldi, Sufian F AD - HFS-517, Division of Microbiological Studies, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA, sufian.alkhaldi@fda.hhs.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 163 EP - 171 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 20 IS - 3-4 SN - 0890-8508, 0890-8508 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - DNA microarray KW - Salmonella typhimurium KW - PCR KW - Virulence KW - Genomes KW - rRNA KW - Data processing KW - DNA probes KW - Polymerase chain reaction KW - DNA microarrays KW - Oligonucleotides KW - W 30910:Imaging KW - A 01116:Bacteria KW - N 14810:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19969191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Using+PCR+amplification+to+increase+the+confidence+level+of+Salmonella+typhimurium+DNA+microarray+chip+hybridization&rft.au=Courtney%2C+Shannon%3BMossoba%2C+Miriam+E%3BHammack%2C+Thomas+S%3BKeys%2C+Christine%3BAl-Khaldi%2C+Sufian+F&rft.aulast=Courtney&rft.aufirst=Shannon&rft.date=2006-06-01&rft.volume=20&rft.issue=3-4&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2005.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; rRNA; Data processing; DNA probes; Polymerase chain reaction; Oligonucleotides; DNA microarrays; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.mcp.2005.12.001 ER - TY - JOUR T1 - In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques AN - 19964604; 6999323 AB - Immunodeficiency after peripheral blood progenitor cell (PBPC) transplantation may be influenced by graft composition, underlying disease, and/or pre-treatment. These factors are difficult to study independently in humans. Ex vivo culture and genetic manipulation of PBPC grafts may also affect immune reconstitution, with relevance to gene therapy applications. We directly compared the effects of three clinically relevant autologous graft compositions on immune reconstitution after myeloblative total body irradiation in rhesus macaques, the first time these studies have been performed in a large animal model with direct clinical relevance. Animals received CD34 super(+) cell dose-matched grafts of either peripheral blood mononuclear cells, purified CD34 super(+) PBPCs, or purified CD34 super(+) PBPCs expanded in vitro and retrovirally transduced. We evaluated the reconstitution of T, B, natural killer, dendritic cells, and monocytes in blood and lymph nodes for up to 1 year post-transplantation. Animals receiving selected-transduced CD34 super(+) cells had the fastest recovery of T-cell numbers, along with the highest T-cell-receptor gene rearrangement excision circles levels, the fewest proliferating Ki-67 super(+) T-cells in the blood, and the best-preserved thymic architecture. Selected-transduced CD34 super(+) cells may therefore repopulate the thymus more efficiently and promote a higher output of naive T-cells. These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation. JF - Stem Cells AU - Lore, Karin AU - Seggewiss, Ruth AU - Guenaga, FJavier AU - Pittaluga, Stefania AU - Donahue, Robert E AU - Krouse, Allen AU - Metzger, Mark E AU - Koup, Richard A AU - Reilly, Cavan AU - Douek, Daniel C AU - Dunbar, Cynthia E AD - Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland. Hematopathology Section, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Division of Biostatistics, University of Minnesota, Twin Cities, Minnesota Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1539 EP - 1548 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Gene therapy KW - Thymus KW - Animal models KW - Immunodeficiency KW - Natural killer cells KW - Cell culture KW - CD34 antigen KW - Clinical trials KW - Lymph nodes KW - Immune reconstitution KW - Dendritic cells KW - Stem cells KW - Peripheral blood mononuclear cells KW - Radiation KW - gene rearrangement KW - Lymphocytes T KW - Hemopoiesis KW - Macaca mulatta KW - Monocytes KW - W 30905:Medical Applications KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=In+Vitro+Culture+During+Retroviral+Transduction+Improves+Thymic+Repopulation+and+Output+After+Total+Body+Irradiation+and+Autologous+Peripheral+Blood+Progenitor+Cell+Transplantation+in+Rhesus+Macaques&rft.au=Lore%2C+Karin%3BSeggewiss%2C+Ruth%3BGuenaga%2C+FJavier%3BPittaluga%2C+Stefania%3BDonahue%2C+Robert+E%3BKrouse%2C+Allen%3BMetzger%2C+Mark+E%3BKoup%2C+Richard+A%3BReilly%2C+Cavan%3BDouek%2C+Daniel+C%3BDunbar%2C+Cynthia+E&rft.aulast=Lore&rft.aufirst=Karin&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Thymus; Natural killer cells; Immunodeficiency; Animal models; CD34 antigen; Cell culture; Clinical trials; Lymph nodes; Immune reconstitution; Dendritic cells; Peripheral blood mononuclear cells; Stem cells; Radiation; gene rearrangement; Lymphocytes T; Hemopoiesis; Monocytes; Macaca mulatta ER - TY - JOUR T1 - Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building AN - 19960506; 6878486 AB - We investigated the associations of fungal and endotoxin levels in office dust with respiratory health in 888 (67% participation) occupants of a water-damaged building. We analyzed floor and chair dusts from 338 workstations for culturable fungi and endotoxin. Based on averages, we ranked each floor of the building as low, medium, or high for occupants' exposure to each of these agents. Multivariate logistic regression models for building-related symptoms included this ranking of fungi and endotoxin, age, gender, race, smoking status, and duration of occupancy. Using floor dust measures, we found significantly increased odds for lower respiratory symptoms [wheeze, chest tightness, attacks of shortness of breath, and attacks of cough: odds ratios (OR) = 1.7 (95% confidence interval (CI): 1.02-2.77) to 2.4 (95% CI: 1.29-4.59)], throat irritation [OR = 1.7, (95% CI: 1.06-2.82)], and rash/itchy skin [OR = 3.0, (95% CI: 1.47-6.19)] in the highest fungal exposure group compared to the lowest, with generally linear exposure-response relationships. Nonlinear relationships were observed for many of these symptoms and endotoxin in floor dust. Interaction models showed that endotoxin modified effects of fungi on respiratory symptoms. Our findings of exposure interactions and exposure-response relationships of fungal and endotoxin with increased risk of building-related symptoms contribute to an understanding of the role of microbial agents in building-related asthma and respiratory and systemic symptoms. JF - Indoor Air AU - Park, J-H AU - Cox-Ganser, J AU - Rao, C AU - Kreiss, K AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, Morgantown WV, USA, gzp8@cdc.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 192 EP - 203 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 16 IS - 3 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Health & Safety Science Abstracts KW - Endotoxins KW - Age KW - Pharynx KW - Airborne microorganisms KW - Respiratory diseases KW - Chest KW - Dust KW - Models KW - Smoking KW - Exanthema KW - Dose-response effects KW - Regression analysis KW - Occupational exposure KW - Races KW - Skin KW - Fungi KW - Cough KW - Asthma KW - Irritation KW - Gender KW - Indoor environments KW - H 3000:Environment and Ecology KW - P 0000:AIR POLLUTION KW - A 01490:Miscellaneous KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Fungal+and+endotoxin+measurements+in+dust+associated+with+respiratory+symptoms+in+a+water-damaged+office+building&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J%3BRao%2C+C%3BKreiss%2C+K&rft.aulast=Park&rft.aufirst=J-H&rft.date=2006-06-01&rft.volume=16&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2005.00415.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - SuppNotes - Figures, 4; tables, 4. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Age; Skin; Pharynx; Fungi; Asthma; Cough; Chest; Dust; Irritation; Models; Exanthema; Smoking; Dose-response effects; Regression analysis; Races; Gender; Airborne microorganisms; Respiratory diseases; Indoor environments; Occupational exposure DO - http://dx.doi.org/10.1111/j.1600-0668.2005.00415.x ER - TY - JOUR T1 - Novel Conjugate of Moxifloxacin and Carboxymethylated Glucan with Enhanced Activity against Mycobacterium tuberculosis AN - 19959928; 6944482 AB - Mycobacterium tuberculosis is an intracellular pathogen that persists within macrophages of the human host. One approach to improving the treatment of tuberculosis (TB) is the targeted delivery of antibiotics to macrophages using ligands to macrophage receptors. The moxifloxacin-conjugated dansylated carboxymethylglucan (M-DCMG) conjugate was prepared by chemically linking dansylcadaverine (D) and moxifloxacin (M) to carboxymethylglucan (CMG), a known ligand of macrophage scavenger receptors. The targeted delivery to macrophages and the antituberculosis activity of the conjugate M-DCMG were studied in vitro and in vivo. Using fluorescence microscopy, fluorimetry, and the J774 macrophage cell line, M-DCMG was shown to accumulate in macrophages through scavenger receptors in a dose-dependent (1 to 50 mu g/ml) manner. After intravenous administration of M-DCMG into C57BL/6 mice, the fluorescent conjugate was concentrated in the macrophages of the lungs and spleen. Analyses of the pharmacokinetics of the conjugate demonstrated that M-DCMG was more rapidly accumulated and more persistent in tissues than free moxifloxacin. Importantly, therapeutic studies of mycobacterial growth in C57BL/6 mice showed that the M-DCMG conjugate was significantly more potent than free moxifloxacin. JF - Antimicrobial Agents & Chemotherapy AU - Schwartz, Y S AU - Dushkin, MI AU - Vavilin, V A AU - Melnikova, E V AU - Khoschenko, OM AU - Kozlov, V A AU - Agafonov, A P AU - Alekseev, A Y AU - Rassadkin, Y AU - Shestapalov, A M AU - Azaev AU - Saraev, D V AU - Filimonov, P N AU - Kurunov, Y AU - Svistelnik, A V AU - Krasnov, V A AU - Pathak, A AU - Derrick, S C AU - Reynolds, R C AU - Morris, S AU - Blinov, V M AD - Institute of Clinical Immunology SD RAMS, Novosibirsk, Russia. State Research Center of Virology and Biotechnology Vector, Russian Ministry of Public Health, Koltsovo, Novosibirsk Region, Russia. Novosibirsk Institute of Tuberculosis, Russian Ministry of Public Health, Novosibirsk, Russia. Southern Research Institute, Birmingham, Alabama. FDA/CBER, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1982 EP - 1988 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Intravenous administration KW - Fluorescence KW - Spleen KW - Antibiotics KW - Pathogens KW - Pharmacokinetics KW - Antimicrobial agents KW - Lung KW - Moxifloxacin KW - Microscopy KW - Tuberculosis KW - scavenger receptors KW - glucans KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Novel+Conjugate+of+Moxifloxacin+and+Carboxymethylated+Glucan+with+Enhanced+Activity+against+Mycobacterium+tuberculosis&rft.au=Schwartz%2C+Y+S%3BDushkin%2C+MI%3BVavilin%2C+V+A%3BMelnikova%2C+E+V%3BKhoschenko%2C+OM%3BKozlov%2C+V+A%3BAgafonov%2C+A+P%3BAlekseev%2C+A+Y%3BRassadkin%2C+Y%3BShestapalov%2C+A+M%3BAzaev%3BSaraev%2C+D+V%3BFilimonov%2C+P+N%3BKurunov%2C+Y%3BSvistelnik%2C+A+V%3BKrasnov%2C+V+A%3BPathak%2C+A%3BDerrick%2C+S+C%3BReynolds%2C+R+C%3BMorris%2C+S%3BBlinov%2C+V+M&rft.aulast=Schwartz&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=50&rft.issue=6&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Intravenous administration; Fluorescence; Spleen; Antibiotics; Pathogens; Pharmacokinetics; Antimicrobial agents; Moxifloxacin; Lung; Microscopy; Tuberculosis; glucans; scavenger receptors; Mycobacterium tuberculosis ER - TY - JOUR T1 - Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts AN - 19776359; 6950190 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies were performed to screen for potential toxicities (intrinsic and immunotoxicities). All treatment-related toxicities identified in these repeated-dose toxicology studies have been confined primarily to the sites of injection and seem to be the result of both the delivery method (as they are seen in both control and treated animals) and the intended immune response to the vaccine (as they occur with greater frequency and severity in treated animals). Reactogenicity at the site of injection is generally seen to be reversible as the frequency and severity diminished between doses and between the immediate and recovery termination time points. This observation also correlated with the biodistribution data reported in the companion article (Sheets et al., 2006), in which DNA plasmid vaccine was shown to remain at the site of injection, rather than biodistributing widely, and to clear over time. The results of these safety studies have been submitted to the Food and Drug Administration to support the safety of initiating clinical studies with these and related DNA plasmid vaccines. Thus far, standard repeated-dose toxicology studies have not identified any target organs for toxicity (other than the injection site) for our DNA plasmid vaccines at doses up to 8 mg per immunization, regardless of disease indication (i.e., expressed gene-insert) and despite differences (strengths) in the promoters used to drive this expression. As clinical data accumulate with these products, it will be possible to retrospectively compare the safety profiles of the products in the clinic to the results of the repeated-dose toxicology studies, in order to determine the utility of such toxicology studies for signaling potential immunotoxicities or intrinsic toxicities from DNA vaccines. These data build on the biodistribution studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Andrews, Charla AU - Bailer, Robert AU - Rathmann, John AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 620 EP - 630 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Toxicology Abstracts KW - vaccines KW - Data processing KW - severe acute respiratory syndrome KW - Severe acute respiratory syndrome KW - Ebola virus KW - Toxicity KW - Plasmids KW - Immunization KW - immunization KW - infectious diseases KW - Promoters KW - Immunotoxicity KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Cytokines KW - Immune response KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - Signal transduction KW - V 22360:AIDS and HIV KW - H 14000:Toxicology KW - X 24221:Toxicity testing KW - N 14810:Methods KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicological+Safety+Evaluation+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar+Despite+Differing+Plasmid+Backbones+or+Gene-Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BAndrews%2C+Charla%3BBailer%2C+Robert%3BRathmann%2C+John%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Toxicity; Plasmids; Immunization; Promoters; Immunotoxicity; DNA vaccines; Infectious diseases; Cytokines; Vaccines; Immune response; Signal transduction; Immunoglobulins; immunization; infectious diseases; vaccines; severe acute respiratory syndrome; DNA; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - Purchaser strategies to influence quality of care: from rhetoric to global applications AN - 19553417; 8747484 AB - The potential of purchasers to influence the quality and safety of care has captured the attention of health sector leaders worldwide. Quality based purchasing explicitly seeks to hold providers accountable for the quality and safety of care. Three strategies are available to purchasers: (1) selective contracting based on quality; (2) payment differentials based on quality; and (3) sponsorship of comparative provider report cards. Examples are given to illustrate each of the three strategies. Governments, employers, social insurance funds, community based insurance organizations, health plans, donors, and other buyers of health services are encouraged to explore and debate these purchaser strategies within the context of an overarching national or local quality framework. Public and private funders of operations research are encouraged to support and disseminate evaluations of purchaser efforts to improve quality. This paper is designed to highlight and frame purchasers' strategies explicitly crafted to enhance the quality and safety of care. The ultimate aim is to encourage thoughtful discussion about whether or not one or more purchaser strategy might support a particular country's goals to improve care. Experiences from both developed and developing countries are included to facilitate the exchange of ideas and provide the broadest of perspectives. JF - Quality & Safety in Health Care AU - McNamara, P AD - Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA, pmcnamar@ahrq.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 VL - 15 IS - 3 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - community involvement KW - Insurance KW - funds KW - Health care KW - operations research KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19553417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Purchaser+strategies+to+influence+quality+of+care%3A+from+rhetoric+to+global+applications&rft.au=McNamara%2C+P&rft.aulast=McNamara&rft.aufirst=P&rft.date=2006-06-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Insurance; operations research; funds; Health care; community involvement; Developing countries ER - TY - JOUR T1 - Histopathological Effects in Fish Exposed to the Toxins from Karlodinium micrum AN - 19462459; 7026224 AB - Karlodinium micrum (family Dinophyceae) produces toxic compounds (KmTx's) that are associated with fish kills. For zebrafish Danio rerio larvae (24 h old) exposed to either KmTx 1 or KmTx 2, mortality (100% in 24 h) was observed at toxin concentrations of 1 mu g/mL or more, whereas no mortality occurred after 24 h at concentrations of 0.5 mu g/mL or less. Zebrafish and sheepshead minnow Cyprinodon variegatus juveniles (60-90 d old) exposed to KmTx 2 were more sensitive to the toxin's effects than larvae were; mortalities in the juveniles began at 0.1-0.5 mu g/mL. In whole, sectioned juvenile zebrafish, gills were the primary site showing injury by light microscopy. Histology of gills in both species treated with 0.5 mu g KmTx 2/mL (100% mortality in 1 h) showed epithelial necrosis and shortening or loss of secondary lamellae. Histology of zebrafish gills treated with 0.05 and 0.1 mu g/mL (0-44% mortality in 4 h) showed clubbing and bridging between secondary lamellae within 4 h of exposure. Sheepshead minnow exposed to 0.1 mu g/mL showed similar gill pathology but no mortality after 6 h. Sheepshead minnow exposed to KmTx 2 at 0.5 mu g/mL or more all died in less than 1 h. Transmission electron microscopy of gills of moribund zebrafish exposed to 0.1 mu g/mL revealed extensive cellular hypertrophy and lysis of epithelial and chloride cells. Because concentrations of KmTx 1 and KmTx 2 range from 0.1 to 0.8 mu g/mL in filtered water samples from K. micrum-associated fish kills, these results suggest that the concentrations of KmTx 1 and KmTx 2 found during fish kills are acutely toxic to fish and that gills are a primary target. JF - Journal of Aquatic Animal Health AU - Deeds, Jonathan R AU - Reimschuessel, Renate AU - Place, Allen R AD - University of Maryland Biotechnology Institute, Center of Marine Biotechnology, 701 East Pratt Street, Suite 236, Baltimore, Maryland 21202, USA; and U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Seafood, 8301 Muirkirk Road, Laurel, Maryland 20708, USA Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 136 EP - 148 PB - American Fisheries Society, 5410 Grosvenor Ln. Ste. 110 Bethesda MD 20814-2199 USA VL - 18 IS - 2 SN - 0899-7659, 0899-7659 KW - Sheepshead minnow KW - Zebra danio KW - Zebra fish KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Aquatic animals KW - Injuries KW - Toxicants KW - Pathology KW - Transmission electron microscopy KW - Lamellae KW - Phytoplankton KW - Histopathology KW - Chloride KW - Dinophyceae KW - Freshwater KW - Freshwater fish KW - Toxicity tests KW - Fish larvae KW - Fish kill KW - Necrosis KW - Gills KW - Mortality KW - Biological poisons KW - Toxins KW - Danio rerio KW - Hypertrophy KW - Microscopy KW - Karlodinium micrum KW - Cyprinodon variegatus KW - Mortality causes KW - Q1 08346:Physiology, biochemistry, biophysics KW - X 24370:Natural Toxins KW - K 03039:Algae KW - Q5 08504:Effects on organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19462459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aquatic+Animal+Health&rft.atitle=Histopathological+Effects+in+Fish+Exposed+to+the+Toxins+from+Karlodinium+micrum&rft.au=Deeds%2C+Jonathan+R%3BReimschuessel%2C+Renate%3BPlace%2C+Allen+R&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2006-06-01&rft.volume=18&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aquatic+Animal+Health&rft.issn=08997659&rft_id=info:doi/10.1577%2FH05-027.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Fish kill; Pathology; Toxicants; Biological poisons; Histopathology; Phytoplankton; Freshwater fish; Fish larvae; Toxicity tests; Gills; Mortality causes; Aquatic animals; Mortality; Necrosis; Hypertrophy; Injuries; Transmission electron microscopy; Microscopy; Lamellae; Chloride; Toxins; Danio rerio; Dinophyceae; Karlodinium micrum; Cyprinodon variegatus; Freshwater DO - http://dx.doi.org/10.1577/H05-027.1 ER - TY - JOUR T1 - Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity AN - 19455424; 6996344 AB - Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced .OH and [Formula: see text] radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF- Kappa B and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor- alpha . These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumor xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumor cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo. JF - Journal of Biological Chemistry AU - Ding, Min AU - Feng, Rentian AU - Wang, Shiow Y AU - Bowman, Linda AU - Lu, Yongju AU - Qian, Yong AU - Castranova, Vincent AU - Jiang, Bing-Hua AU - Shi, Xianglin AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, the Fruit Laboratory, Beltsville Agricultural Research Center, U. S. Department of Agriculture, Beltsville, Maryland 20705, and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia 26505 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17359 EP - 17368 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 25 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Anthocyanins KW - Cyclooxygenase-2 KW - Transformation KW - Fruits KW - MAP kinase KW - Vegetables KW - Skin KW - Lung carcinoma KW - Food KW - natural products KW - Tumors KW - Tumor cells KW - TPA KW - NF- Kappa B protein KW - Metastases KW - Tumor cell lines KW - U.V. radiation KW - Carcinogenesis KW - Tumor necrosis factor- alpha KW - Cell migration KW - Xenografts KW - Radicals KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19455424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cyanidin-3-glucoside%2C+a+Natural+Product+Derived+from+Blackberry%2C+Exhibits+Chemopreventive+and+Chemotherapeutic+Activity&rft.au=Ding%2C+Min%3BFeng%2C+Rentian%3BWang%2C+Shiow+Y%3BBowman%2C+Linda%3BLu%2C+Yongju%3BQian%2C+Yong%3BCastranova%2C+Vincent%3BJiang%2C+Bing-Hua%3BShi%2C+Xianglin&rft.aulast=Ding&rft.aufirst=Min&rft.date=2006-06-01&rft.volume=281&rft.issue=25&rft.spage=17359&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Cyclooxygenase-2; Anthocyanins; Fruits; Vegetables; MAP kinase; Skin; Lung carcinoma; Food; natural products; Tumors; Tumor cells; TPA; NF- Kappa B protein; Metastases; Tumor cell lines; U.V. radiation; Carcinogenesis; Xenografts; Cell migration; Tumor necrosis factor- alpha; Radicals ER - TY - BOOK T1 - Modeling of hand-arm vibration AN - 19395381; 7157617 AB - The aerospace and automotive industries are facing a significant risk for cumulative trauma disorders from high-repetition, long-duration tasks. Additional risk factors such as shocks, vibrations and sustained uncomfortable postures oftentimes contribute to musculoskeletal, neurological injuries associated with the hand-arm system. The power tools used for the operation reduce the comfort and working efficiency of the operators, thus lowering their health and safety and the quality of operation. This paper investigates the fastening operation on the assembly line of a major aerospace company for quantifying hand-arm vibrations with the objective of developing a dynamic model of the hand-arm system. The model will be used to ascertain the effect of the various risk factors on the quality of the operation. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Joshi, A AU - Guttenberg, R AU - Leu, M C AU - Murray, S L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - cumulative trauma disorders KW - Injuries KW - Vibration KW - Automotive industry KW - Occupational exposure KW - musculoskeletal system KW - posture KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Joshi%2C+A%3BGuttenberg%2C+R%3BLeu%2C+M+C%3BMurray%2C+S+L&rft.aulast=Joshi&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Modeling+of+hand-arm+vibration&rft.title=Modeling+of+hand-arm+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Design of a test bench to evaluate the vibration emission values of jackleg rock drills AN - 19395351; 7157603 AB - Jackleg rock drills are widely used in the mining industry and are known to generate high levels of hand-arm vibration which contribute to the development of the hand-arm vibration syndrome for exposed miners. To reduce the vibration levels, a prototype of an antivibration handle was developed as part of a previous study. To provide some bench marking for this handle prototype and to follow the evolution of its performance over time, a test bench was developed to characterize the vibration emission values of jackleg drills under controlled operating conditions. As the current ISO 8662 series of standards could not apply directly to this type of tool, there was a need to design and validate a test bench to evaluate the vibration emission values of jackleg drills, while taking into account the conditions specific to the operation of this type of tool. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Marcotte, P AU - Ouellette, S AU - Boutin, J AU - Boileaul, P-E AU - Leblanc, G AU - Oddo, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Emissions KW - Emission standards KW - hand-arm vibration syndrome KW - Working conditions KW - Ergonomics KW - Occupational exposure KW - Design KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Marcotte%2C+P%3BOuellette%2C+S%3BBoutin%2C+J%3BBoileaul%2C+P-E%3BLeblanc%2C+G%3BOddo%2C+R&rft.aulast=Marcotte&rft.aufirst=P&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Design+of+a+test+bench+to+evaluate+the+vibration+emission+values+of+jackleg+rock+drills&rft.title=Design+of+a+test+bench+to+evaluate+the+vibration+emission+values+of+jackleg+rock+drills&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Characteristics of whole-body vibration frequencies and low back pain in urban taxi drivers AN - 19395300; 7157591 AB - Occupational exposures to whole-body vibration (WBV) at different frequency domains may differentially affect human comfort and the musculoskeletal system. Under this presumption, a frequency-based weighting scheme has been adapted in many widely accepted standards for WBV measurement. However, there is very little human data showing a direct link between WBV frequency and musculoskeletal disorders. We conducted an epidemiologic study to examine the association between WBV frequency and prevalence of low back pain (LBP) and to identify determinants of specific frequencies associated with LBP in urban taxi drivers. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Chen, J-C AU - Chang, W-R AU - Hatfield, B H AU - Christiani, D C Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - low back pain KW - musculoskeletal system KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chen%2C+J-C%3BChang%2C+W-R%3BHatfield%2C+B+H%3BChristiani%2C+D+C&rft.aulast=Chen&rft.aufirst=J-C&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Characteristics+of+whole-body+vibration+frequencies+and+low+back+pain+in+urban+taxi+drivers&rft.title=Characteristics+of+whole-body+vibration+frequencies+and+low+back+pain+in+urban+taxi+drivers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Pneumatic active suspension design for heavy vehicle seats and operator ride comfort AN - 19395273; 7157571 AB - Handling of heavy vehicles such as tractors, trucks and buses require a large roll stiffness which causes large high accelerations at the seat level during impacts. To provide comfort and minimize the energy transfer from the chassis and the seat a pneumatic active seat suspension is proposed. An active seat suspension design and control algorithm under development at the University of Illinois at Chicago, UIC, is being developed and tested. Preliminary results are presented in this paper. The design of a passive suspension typically consists of optimizing the value of two parameters: the stiffness and the damping of the suspension. The general dynamic performance of the suspension is limited to the conditions under which these parameters were obtained. A change in the input conditions might lead to poor suspension and an amplification of the vibration transmitted to the body. The focus of this paper is a robust, semi-active suspension system with a variable controlled damping and using the body response an index measure to minimize the acceleration at the interface of the seat and operator. A summary of existing suspensions, such as MR and ER fluids, and spring loaded and dual valve shock absorbent will be discussed to highlight the need of a semi-active pneumatic suspension system design. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Valero, B AU - Amirouche, F AU - Mayton, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Illinois, Chicago KW - buses KW - USA, Illinois KW - Vibration KW - Materials handling KW - Trucks KW - Design KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Valero%2C+B%3BAmirouche%2C+F%3BMayton%2C+A&rft.aulast=Valero&rft.aufirst=B&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Pneumatic+active+suspension+design+for+heavy+vehicle+seats+and+operator+ride+comfort&rft.title=Pneumatic+active+suspension+design+for+heavy+vehicle+seats+and+operator+ride+comfort&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of whole-body vibration comfort AN - 19395243; 7157557 AB - The purpose of using experimental subjective and/or perception methods is: (a) to understand human subjective impressions of the physical characteristics of vibration; (b) to determine the relationship between the subjective perception of some aspect of the vibration and an evaluation index of the physical vibration characteristics; and (c) the establishment of target values for design of vibration environments in terms of human sensation of vibration characteristics. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Maeda, S AU - Mansfield, N J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Maeda%2C+S%3BMansfield%2C+N+J&rft.aulast=Maeda&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+whole-body+vibration+comfort&rft.title=Evaluation+of+whole-body+vibration+comfort&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of the capability of seat suspension to reduce the operator exposure to vibration in Track Type Tractors AN - 19394053; 7157608 AB - The European Union (EU) completed a new directive 2002/44/EC called the Physical Agents Directive (PAD) that establishes action and limit values for hand-arm and whole body vibrations. The directive specifies that: "...workers shall not be exposed above the exposure `limit value'." and "...once the exposure action values ... are exceeded, the employer shall establish and implement a programme of technical and/or organisational measures intended to reduce to a minimum exposure to mechanical vibration and the attendant risks... " The PAD limit value is effective for new machines starting July 6, 2007 and for used machines by at least July 6, 2010. These requirements apply to the users of machines, but machine manufacturers will be challenged to provide machines and information to help the users comply with the directive. Caterpillar manufactures machines with the goal of enabling our customers to comply with all regulations dealing with health and safety. Caterpillar designs all of our machines to provide a safe, comfortable and productive work environment. This study was to determine if seat suspensions could provide a reduction in the vibration environment experienced by operators of Caterpillar mid sized (<50,000KG) Track Type Tractors. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Contratto AU - Brodersen, T AU - Marshall, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - tractors KW - Health & Safety Science Abstracts KW - European Union KW - Vibration KW - Occupational exposure KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Contratto%3BBrodersen%2C+T%3BMarshall%2C+D&rft.aulast=Contratto&rft.aufirst=&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+the+capability+of+seat+suspension+to+reduce+the+operator+exposure+to+vibration+in+Track+Type+Tractors&rft.title=Evaluation+of+the+capability+of+seat+suspension+to+reduce+the+operator+exposure+to+vibration+in+Track+Type+Tractors&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Influence of back support conditions on the absorbed power of seated occupants under horizontal vibration AN - 19394028; 7157594 AB - The absorbed power (P sub(Abs)) has been suggested as a better measure of human responses to whole-body vibration, since it relates to the cumulative energy dissipated by the body exposed over a given duration. Moreover, unlike the other measures, the P sub(Abs) can adequately account for the intensity of exposure. Although, the vast majority of off-road vehicles impose considerably severe vibration along the horizontal axes, the vast majority of studies on biodynamic response characterization consider only vertical vibration. Only a few studies have reported P sub(Abs) responses of the seated human body exposed to horizontal vibration and the major contributing factors. This study aims to characterize the P sub(Abs) responses of seated human subjects to horizontal (uncoupled x- and y-axis) vibration as functions of the vibration intensity, subject mass, seat height and the, type of back support. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Mandapuram, S AU - Rakheja, S AU - Ma, S AU - Boileau, P-E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mandapuram%2C+S%3BRakheja%2C+S%3BMa%2C+S%3BBoileau%2C+P-E&rft.aulast=Mandapuram&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Influence+of+back+support+conditions+on+the+absorbed+power+of+seated+occupants+under+horizontal+vibration&rft.title=Influence+of+back+support+conditions+on+the+absorbed+power+of+seated+occupants+under+horizontal+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Comfort evaluation for mine shuttle car seat designs AN - 19394007; 7157567 AB - Industrial equipment exposes individuals to whole-body vibration (WBV) and mechanical shock. This exposure can negatively impact their health, safety, comfort, and working efficiency and performance. Accordingly, proper seat design is an important consideration in reducing the adverse effects of WBV exposure to vehicle operators. Since the human body is sensitive to low frequency WBV, ride quality is a basic and important element of good seat design. When designing a suitable seat, it is essential to understand vibration exposure environment of workers and how well they can tolerate this environment This is particularly true in the mining industry. Mayton et al. reported on a low-coal shuttle car seat design that underwent limited, yet successful underground mine trials. Building on this work, a follow-up study compared NIOSH and existing seat designs on low- and mid-coal seam shuttle cars. The NIOSH seat designs included viscoelastic foam, which has properties similar to those found in a mechanical spring/damper suspension system. The seats also included an adjustable lumbar support and a fore-aft seat adjustment. The NIOSH seat designs contrast with the existing seat design, which have little or no lumbar support and include inexpensive foam padding of the type commonly used in furniture. This paper will focus on the seat designs for the mid-coal seam shuttle car and compare subjective comfort data collected from five vehicle operators with ISO 2631 - based reduced comfort boundary (RCB) analysis of recorded vibration levels. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Mayton, A AU - Jobes, C AU - Kittusamy, N K AU - Amirouche, F Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - safety engineering KW - Vibration KW - Mines KW - USA, Connecticut, Hartford Basin, Newark Supergroup, Shuttle KW - Protective equipment KW - Occupational exposure KW - Side effects KW - Design KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mayton%2C+A%3BJobes%2C+C%3BKittusamy%2C+N+K%3BAmirouche%2C+F&rft.aulast=Mayton&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Comfort+evaluation+for+mine+shuttle+car+seat+designs&rft.title=Comfort+evaluation+for+mine+shuttle+car+seat+designs&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Training Simulators Extend Laboratory Testing Techniques for WBV Analysis AN - 19392903; 7157613 AB - Human testing has always been a needed way to provide information on the effects of vehicle vibration, however, the manner of testing has not reflected the real situations of driver's hands on a steering wheel and a seat with back support and driving tasks. The typical system have used a standard sinusoidal excitation rather than the typical types of road - truck excitations The new truck driver training simulators provide the combination of road roughness, speed effects, cab environment and individual tasks. The system has a full six axis simulation potential. The simulators have the protection of the individual by a combination of two ways for the individual to stop the motion as well as an operator with visual capability who can stop the testing. The closed simulator, has the potential for providing motion during v the operation. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wasserman, J AU - Mullinix, L AU - Khanal, S AU - Hinton, G AU - Wasserman, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Laboratory testing KW - Training KW - driving ability KW - Vibration KW - Simulation KW - Trucks KW - Highways KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wasserman%2C+J%3BMullinix%2C+L%3BKhanal%2C+S%3BHinton%2C+G%3BWasserman%2C+D&rft.aulast=Wasserman&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Training+Simulators+Extend+Laboratory+Testing+Techniques+for+WBV+Analysis&rft.title=Training+Simulators+Extend+Laboratory+Testing+Techniques+for+WBV+Analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration time and rest time during sinusoidal vibration experiments: Do these factors affect comfort ratings? AN - 19392868; 7157623 AB - Industrial exposure to whole-body vibration is associated with injury and discomfort. Certain industries, notably mining, construction, and forestry, involve complex 6 degrees of freedom vibration. Laboratory-based studies of vibration are essential for controlled and systematic evaluation of the human responses to vibration. The purpose of this pilot study was to evaluate whether the duration of the vibration exposure, and rest between vibrations, significantly influence the subjective ratings of comfort during laboratory-based studies of vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dickey, J P AU - Oliver, M L AU - Shee, NKL AU - Boileau, P-E AU - Eger, T R AU - Trick, L M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Vibration KW - Occupational exposure KW - Working conditions KW - Forestry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dickey%2C+J+P%3BOliver%2C+M+L%3BShee%2C+NKL%3BBoileau%2C+P-E%3BEger%2C+T+R%3BTrick%2C+L+M&rft.aulast=Dickey&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+time+and+rest+time+during+sinusoidal+vibration+experiments%3A+Do+these+factors+affect+comfort+ratings%3F&rft.title=Vibration+time+and+rest+time+during+sinusoidal+vibration+experiments%3A+Do+these+factors+affect+comfort+ratings%3F&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Head-trunk motion increase with arm-rest controls AN - 19392864; 7157610 AB - Heavy equipment manufacturers have made a long-term commitment to minimize operator vibration exposure for comfort, performance, and health reasons. Domestic and international guidelines/standards and EC laws dictate exposure limits based on measurement of vibration at the interface between the seat and the operator's buttocks using seat-pad accelerometry. This is historically based on the assumption that the only major source of vibration is transmitted through the seat pan. However, vibration may also be imparted to the head and neck via the steering wheel and/or arm-rest controls and a relatively rigid upper body. Unfortunately, little is known regarding the influence of arm position on head and neck motion. The purpose of this study was to investigate relative head and trunk motions during riding simulations of large construction equipment, using three different arm control options. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Rahmatalla, S AU - Contratto, M AU - Xia, T AU - Frey-Law, L AU - Kopp, G AU - Grosland, N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Vibration KW - Simulation KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BRahmatalla%2C+S%3BContratto%2C+M%3BXia%2C+T%3BFrey-Law%2C+L%3BKopp%2C+G%3BGrosland%2C+N&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Head-trunk+motion+increase+with+arm-rest+controls&rft.title=Head-trunk+motion+increase+with+arm-rest+controls&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Clinical assessment and characteristics of men and women exposed to high level of hand-arm vibration AN - 19392839; 7157619 AB - While the neurological and vascular aspects of Hand-Arm Vibration Syndrome (HAVS) has been generally accepted as a medical condition, the medical criteria and the clinical findings used to establish the diagnosis has been more difficult to bring to consensus. The criteria was first quantified by the Taylor-Palmear scale. This criteria was subsequently modified in 1986 at the 1 Stockholm Workshop to included more acceptance for the neurological effects that characterized the predominate findings in some workers. The relationship between hand-arm vibration and Carpal Tunnel Syndrome was defined in NIOSH 97-141. The purpose of this study is to look at recent case studies of men and women exposed to jobs with high levels of hand-arm vibration with extensive clinical testing for both the neurological and vascular components of HAVS as well as other associated upper extremity conditions such as Carpal Tunnel Syndrome. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jetzer, T AU - Ketcham, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Sweden, Stockholm KW - Vibration KW - carpal tunnel syndrome KW - overuse injuries KW - males KW - hand-arm vibration syndrome KW - Females KW - musculoskeletal system KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jetzer%2C+T%3BKetcham%2C+D&rft.aulast=Jetzer&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Clinical+assessment+and+characteristics+of+men+and+women+exposed+to+high+level+of+hand-arm+vibration&rft.title=Clinical+assessment+and+characteristics+of+men+and+women+exposed+to+high+level+of+hand-arm+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A portable measurement system for the assessment of time weighted and impulsive exposures to whole body vibration AN - 19392823; 7157593 AB - Bus drivers represent a large segment of the US transportation industry and research has shown an association between exposure to Whole Body Vibration (WBV) and the high rates of low back disorders. Impulsive WBV exposures have been recognized as a risk factor for low back injury and new guidelines exist for their measurement and assessment (ISO 2631, Part 5). Methods to accurately and better characterize the impulsiveness of WBV along with the temporal patterns of the exposures are needed. The development of a hardware and software system to measure continuous TWA and raw, impulsive WBV exposures and the design of a subsequent study are presented. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Johnson, P W AU - Ploger, J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Computer programs KW - Transportation KW - Injuries KW - Vibration KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+P+W%3BPloger%2C+J&rft.aulast=Johnson&rft.aufirst=P&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+portable+measurement+system+for+the+assessment+of+time+weighted+and+impulsive+exposures+to+whole+body+vibration&rft.title=A+portable+measurement+system+for+the+assessment+of+time+weighted+and+impulsive+exposures+to+whole+body+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A novel theory: Ellipse of grip force AN - 19392816; 7157615 AB - Hand forces are important factors for risk assessment of hand-arm vibration syndrome (HAVS) Grip force is one of the most important force components in the operation of powered hand tools. A considerable number of studies on grip force have been reported. It is well known that the grip force applied on a cylindrical handle is not uniformly distributed on each axis across the center of the handle cross-section. Therefore, maximum and minimum orientations of grip force exist around the handle. Such orientations have not been clearly identified. In a recently proposed international standard (ISO/CD 15230, 2005), it is stated that "the direction of the main gripping force is generally parallel to the z-axis defined in ISO 8727." This assertion is questionable, and further examinations are required. The objective of this study was to establish a fundamental theory on the distribution of the grip force around cylindrical handles. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dong, R G AU - Welcome, DE AU - Warren, C AU - Dong, CL AU - McDowell, T W AU - Wu, J Z Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Vibration KW - hand-arm vibration syndrome KW - hand tools KW - Occupational exposure KW - International standardization KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BWarren%2C+C%3BDong%2C+CL%3BMcDowell%2C+T+W%3BWu%2C+J+Z&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+novel+theory%3A+Ellipse+of+grip+force&rft.title=A+novel+theory%3A+Ellipse+of+grip+force&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Upper body joint coordination under vibration AN - 19392795; 7157583 AB - Whole body vibration is known to affect movement accuracy, however little is known about changes in the organization of movement and movement strategies used to limit the influences of perturbations. The specific aim of this work is to analyze the motion and coordination of upper body segments of seated operators performing reaching tasks under whole-body sinusoidal vibration exposure and simulated vehicle ride motion. The long-term objective is to model reach coordination and predict the dynamic behavior of the upper body motion under vehicle vibration exposure. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Lee, J AU - Yoon, J-H AU - Rider, K AU - Martin, B J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lee%2C+J%3BYoon%2C+J-H%3BRider%2C+K%3BMartin%2C+B+J&rft.aulast=Lee&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Upper+body+joint+coordination+under+vibration&rft.title=Upper+body+joint+coordination+under+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Arm and shoulder muscle activity are greater with steering wheel vs. seat mounted controls AN - 19392768; 7157611 AB - Chronic whole-body vibration exposure, as expected in large construction and mining vehicles, has been associated with neck and back pain and injury. While work has been done towards gaining a better understanding of the relationship between vibration and shock and muscle activity of the back musculature, relatively little information regarding the activity of neck, shoulder and upper arm muscles is known. Today's equipment designs must conform to domestic and international standards, however these standards do not specifically address the vibration exposure in the head and upper quarter. Further it is not well known how the control configuration within a vehicle (e.g. steering wheel versus arm controls) influences muscle voluntary and reflex activity levels. Greater muscle activity may lead to greater muscle fatigue -which in turn may be associated with greater risk of injury. Thus, muscle contractions needed to maintain static postures as well as those resulting reflexively should be considered during an analysis of seating position. Unfortunately, little is known regarding the influence of arm position on head and neck muscle function. The purpose of this study was to investigate the relative muscle activities of 5 neck, shoulder, and upper arm muscles during riding simulations of large construction equipment, using three different arm control options. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Law, L F AU - Rahmatalla, S AU - Wilder, D AU - Grosland, N AU - Xia, T AU - Hunstad, T AU - Contratto, M AU - Kopp, G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Vibration KW - Muscles KW - Simulation KW - Mining KW - back pain KW - Construction industry KW - fatigue KW - International standardization KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Law%2C+L+F%3BRahmatalla%2C+S%3BWilder%2C+D%3BGrosland%2C+N%3BXia%2C+T%3BHunstad%2C+T%3BContratto%2C+M%3BKopp%2C+G&rft.aulast=Law&rft.aufirst=L&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Arm+and+shoulder+muscle+activity+are+greater+with+steering+wheel+vs.+seat+mounted+controls&rft.title=Arm+and+shoulder+muscle+activity+are+greater+with+steering+wheel+vs.+seat+mounted+controls&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Simulation of human motion, muscle forces and lumbar spine stresses due to whole-body-vibration: Application of the dynamic human model casimir for the development of commercial vehicles and passenger cars AN - 19392753; 7157575 AB - In the development of commercial vehicles as well as of passenger cars, the effects of vehicle vibrations on operating safety, health and comfort can only be predicted by numerical simulation when appropriate occupant models are available. Such models must be based on human anatomy and have dynamic properties of real humans in order to achieve realistic results. Since human dynamic behavior depend on posture and percentile, the occupant model needs to be adjustable to these parameters with respect to geometry and dynamic properties. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Pankoke, S AU - Siefert, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Vibration KW - Muscles KW - Simulation KW - Stress KW - Occupational exposure KW - Anatomy KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pankoke%2C+S%3BSiefert%2C+A&rft.aulast=Pankoke&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Simulation+of+human+motion%2C+muscle+forces+and+lumbar+spine+stresses+due+to+whole-body-vibration%3A+Application+of+the+dynamic+human+model+casimir+for+the+development+of+commercial+vehicles+and+passenger+cars&rft.title=Simulation+of+human+motion%2C+muscle+forces+and+lumbar+spine+stresses+due+to+whole-body-vibration%3A+Application+of+the+dynamic+human+model+casimir+for+the+development+of+commercial+vehicles+and+passenger+cars&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Establishment of an experimental system for measring biodynamic response of hand-arm AN - 19392749; 7157612 AB - This paper addresses establishment of an experimental system for measuring biodynamic response (BR) of hand-arm system at the NIIH in Japan. BR measurement system at the NIIH is nearly equivalent to NIOSH installed system. The feasibility of the system is examined through the apparent mass (AM) measurement of the empty handle and a set of calibration masses. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Hosoya, N AU - Maeda, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Feasibility studies KW - Hand-arm vibration syndrome KW - Conferences KW - Vibration KW - Japan KW - Working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hosoya%2C+N%3BMaeda%2C+S&rft.aulast=Hosoya&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Establishment+of+an+experimental+system+for+measring+biodynamic+response+of+hand-arm&rft.title=Establishment+of+an+experimental+system+for+measring+biodynamic+response+of+hand-arm&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Measurement and evaluation of vibration exposure for locomotive crew members AN - 19392743; 7157606 AB - The vibration and impact environment for crew members on locomotives has been investigated in a series of studies conducted by Exponent Failure Analysis Associates (Exponent) beginning in 1990. Locomotive cab vibration and impact levels were measured on a variety of locomotive models operating over many different track sections across the Union Pacific, Burlington Northern Santa Fe, CSX, Norfolk Southern, and CONRAIL systems. The comfort and health implications of exposure to the measured locomotive vibration levels were evaluated by comparison with the human vibration exposure boundaries given in the International Standards Organization (ISO) standard 2631-1:1997, the British Standard 6841:1987, European Union (EU) Directive 2002/44/EC, measurements made by Exponent on various commercial and recreational vehicles, and vibration exposure measurement data found in the literature. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Larson, R AU - Raasch, C AU - Pierce, J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - European Union KW - locomotives KW - USA, Vermont, Burlington KW - Vibration KW - IN, Pacific KW - Crew safety KW - ANE, British Isles, England, Norfolk KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Larson%2C+R%3BRaasch%2C+C%3BPierce%2C+J&rft.aulast=Larson&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Measurement+and+evaluation+of+vibration+exposure+for+locomotive+crew+members&rft.title=Measurement+and+evaluation+of+vibration+exposure+for+locomotive+crew+members&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration spectral class characterization of long haul dump mining vehicles and seat performance evaluation AN - 19392712; 7157560 AB - Long-haul dump (LHD) vehicles used in underground mining are known to expose workers to important levels of whole-body vibration. These vehicles are generally designed without suspension and may be categorized as small or large LHDs depending on whether their respective load capacities are lower or larger than 3.5 cubic yards. While the majority of older vehicles are equipped with a rigid or unsuspended seat, more recent LHDs often incorporate a suspension seat. The objective of this study was to define the vibration spectral characteristics of most commonly encountered large and small LHD vehicles operating in mining operations. This was done in an effort to categorize the vehicles in terms of vibration spectral classes to be reproduced on a laboratory whole-body vibration simulator to assess the vibration attenuation performance of a typical LHD suspension seat. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Boileau, P-E AU - Boutin, J AU - Eger, T AU - Smets, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Mining KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Boileau%2C+P-E%3BBoutin%2C+J%3BEger%2C+T%3BSmets%2C+M&rft.aulast=Boileau&rft.aufirst=P-E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+spectral+class+characterization+of+long+haul+dump+mining+vehicles+and+seat+performance+evaluation&rft.title=Vibration+spectral+class+characterization+of+long+haul+dump+mining+vehicles+and+seat+performance+evaluation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Whole-body vibration exposure and driver posture evaluation during the operation of LHD vehicles in underground mining AN - 19392711; 7157605 AB - Load-haul dump vehicles (LHDs) are used to move waste rock and ore in underground mining operations. The LHD is designed for bi-directional operation and the driver sits sideways to the direction of travel. LHD operators have higher reports of low back pain and neck discomfort than other mobile equipment operators who do not sit sideways in the vehicle, but are exposed to whole-body vibration (WBV). Exposure to WBV is linked with reports of lower-back pain, neck problems and spinal degeneration. Static sitting postures, sitting with the neck and back twisted, and sitting with the back in an unsupported posture are also linked with an increased risk of developing back pain. The objective of this study was to determine typical vibration exposure levels and driving postures for LHD operators. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Eger, T AU - Stevenson, J AU - Grenier, S AU - Boileau, P-E AU - Smets, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - low back pain KW - Mining KW - Ergonomics KW - Working conditions KW - Occupational exposure KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Eger%2C+T%3BStevenson%2C+J%3BGrenier%2C+S%3BBoileau%2C+P-E%3BSmets%2C+M&rft.aulast=Eger&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Whole-body+vibration+exposure+and+driver+posture+evaluation+during+the+operation+of+LHD+vehicles+in+underground+mining&rft.title=Whole-body+vibration+exposure+and+driver+posture+evaluation+during+the+operation+of+LHD+vehicles+in+underground+mining&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Effects of short-term exposure to whole-body vibration on wakefulness AN - 19392707; 7157584 AB - Whole-body vibration occurs when the body is supported on a surface which is vibrating. Occupational exposures to whole-body vibration mainly occurs in the transportation industry, but also in association with other industrial process. Epidemiological studies have frequently indicated an elevated health risk for the spine in workers exposed to whole-body vibration. With regarding to train or bus operators, a fall of drivers' wakefulness level because of fatigue is often pointed out. This decrease in wakefulness results in an increase of the occurrence of accidents. However, a study of how whole-body vibration affects people's level of wakefulness has not been done. To test the hypothesis that exposure to whole-body vibration has a certain effects on level of wakefulness, the change of a subjective wakefulness level and changes of electroencephalogram (EEG) were observed under experimental exposure to short-term whole-body vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Satou, Y AU - Ando, H AU - Ishitake, T Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Accidents KW - spine KW - Transportation KW - Conferences KW - Vibration KW - Occupational exposure KW - fatigue KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Satou%2C+Y%3BAndo%2C+H%3BIshitake%2C+T&rft.aulast=Satou&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Effects+of+short-term+exposure+to+whole-body+vibration+on+wakefulness&rft.title=Effects+of+short-term+exposure+to+whole-body+vibration+on+wakefulness&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Computational simulation of a pneumatic chipping hammer AN - 19392704; 7157602 AB - Occupational exposure to hand transmitted vibration (HTV) arises from the hand held powered tools extensively used in the mining and construction industry such as rock drills, chipping hammers, chain saws etc. Regular exposure to HTV is the major cause of a range of permanent injuries to human hands and arms which are commonly referred to as hand-arm vibration syndrome (HAVS). In addition to this, the percussive tools generate overall sound power levels in excess of 1 10dBA in most cases. Such a high sound power level greatly exceeds the maximum permissible exposure limit (PEL) of organizations such as National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA). Long term occupational exposure to this noise has been diagnosed as the main reason for permanent hearing loss in the operators. It is therefore important to develop an understanding of the mechanisms which lead to these high vibration and sound levels and in order to do this a detailed computational model of a pneumatic chipping hammer has been made. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kadam, R AU - Schwartz, K AU - Johnson, M AU - Burdisso, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Federal regulations KW - Injuries KW - Vibration KW - Simulation KW - safety regulations KW - hand-arm vibration syndrome KW - Hearing loss KW - Occupational exposure KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kadam%2C+R%3BSchwartz%2C+K%3BJohnson%2C+M%3BBurdisso%2C+R&rft.aulast=Kadam&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Computational+simulation+of+a+pneumatic+chipping+hammer&rft.title=Computational+simulation+of+a+pneumatic+chipping+hammer&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Comparison of anti-vibration interventions for use with fastening tools in metal AN - 19392683; 7157599 AB - Tool manufacturers continue to incorporate new designs to the internal mechanism of tools in order to decrease the vibration that is delivered to the hand during operation. Modification of some tools to minimize tool vibration is not easily resolved through internal tool design. For this reason, vibration damping materials applied between the tool and the hand are a simple alternative. The damping materials may be applied to the area of the tool directly contacted by the operator or in a glove containing a vibration absorbing pad. These interventions are developed specifically to damp vibration but are not necessarily produced and tested under the same work conditions that a company may expose their workers. Therefore, it is important to test the value of the proposed interventions for the specific applications. This study evaluates the effectiveness of anti-vibration interventions currently in use at a local manufacturing company. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dale, A M AU - Standeven, J AU - Evanoff, B Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Manufacturing industry KW - Vibration KW - gloves KW - Occupational exposure KW - Hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dale%2C+A+M%3BStandeven%2C+J%3BEvanoff%2C+B&rft.aulast=Dale&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Comparison+of+anti-vibration+interventions+for+use+with+fastening+tools+in+metal&rft.title=Comparison+of+anti-vibration+interventions+for+use+with+fastening+tools+in+metal&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Response to sudden load by patients with back pain AN - 19392663; 7157582 AB - As mechanical shock and vibration environments evolve, it is important to understand their potential effect on human operators. Human beings are sophisticated mechanisms comprised not only of passive components with mass, damping, and stiffness characteristics, but also of components that can actively affect apparent mass, stiffness, and damping. Because the lumbar spine can exhibit local, short-column buckling, stability of the human trunk depends on the responsiveness of the neuromuscular control system. We have been evaluating the ability of patients with back pain to respond to a series of sudden loads. We believe the results have implications for isolation design and standards development. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Xia, T AU - Gudavalli, R AU - Owens, E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Conferences KW - Vibration KW - back pain KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BXia%2C+T%3BGudavalli%2C+R%3BOwens%2C+E&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Response+to+sudden+load+by+patients+with+back+pain&rft.title=Response+to+sudden+load+by+patients+with+back+pain&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Using an air bladder seat shock isolation system to protect military vehicle occupants from mine blasts AN - 19392660; 7157559 AB - Landmines are a great threat to military vehicles and their occupants. Mine blasts can completely destroy vehicles and kill all the occupants or disable the vehicle and leave the occupants severely injured. Injuries sustained during a landmine blast come from fragmentation that enters the vehicle through a hull breach, hot gasses expanding through the vehicle, or shock created from the extreme pressure of the blast (Lafrance, L.P. 1998). Mitigating the high acceleration experienced by the occupants during survivable mine blasts is the focus of the research being addressed in this paper. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Reynolds, D D AU - Liu, Q AU - Deeb, T Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - landmines KW - Injuries KW - Vibration KW - Military KW - Explosions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reynolds%2C+D+D%3BLiu%2C+Q%3BDeeb%2C+T&rft.aulast=Reynolds&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Using+an+air+bladder+seat+shock+isolation+system+to+protect+military+vehicle+occupants+from+mine+blasts&rft.title=Using+an+air+bladder+seat+shock+isolation+system+to+protect+military+vehicle+occupants+from+mine+blasts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Neuromotor habituation as a mechanism for vibration induced low back pain AN - 19392653; 7157570 AB - Occupational exposure to whole body vibration has long been associated with increased incidence of low back pain and low back injuries. A number of studies have investigated transmissibility of seat pan vibration. While transmissibility has been well researched, the mechanism by which vibration may induce injury has not been thoroughly studied. Winter et al. identified increased reflex response delay after vibration exposure and speculated that muscular fatigue may be the cause of this increase. However, a mechanism has yet to be demonstrated completely. A potential mechanism that may explain the increased risk is neuromotor habituation. Muscle spindle organs have been shown in the extremities to be sensitive to muscle and tendon vibration. Rapid length changes in muscle have been shown to result in kinesthetic illusions as the regular firing of the muscle spindles is interpreted as muscle lengthening. These illusions have also been demonstrated in the paraspinal musculature. With removal of vibration, research in the extremities has demonstrated increased positioning errors, probably due to neuromotor habituation. In this research, it has been hypothesized that neuromotor habituation after exposure to occupational vibration will increase positioning errors. It is further hypothesized that these errors can be shown to be linked to increased reflex response time. Such increased reflex response time could, in turn, decrease spinal stability and increase low back injury risk. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilson, SE AU - Li, L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Conferences KW - Vibration KW - Muscles KW - low back pain KW - extremities KW - Organs KW - fatigue KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilson%2C+SE%3BLi%2C+L&rft.aulast=Wilson&rft.aufirst=SE&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Neuromotor+habituation+as+a+mechanism+for+vibration+induced+low+back+pain&rft.title=Neuromotor+habituation+as+a+mechanism+for+vibration+induced+low+back+pain&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Seated human response to simple and complex impacts AN - 19392633; 7157581 AB - The human lumbar spine is inherently an unstable structure and requires sophisticated neuromuscular control to maintain its stability and for performing physical tasks. As a consequence, it is important to understand the potential health effects on human operators of mechanical stimuli such as shock and vibration. Impact applied to a vehicle operator combines the risk of sudden, unexpected load with the mechanical stress of the seated posture. Because many work environments contain the potential for multiple, unexpected impacts, it is important to understand how the trunk muscles respond to complex conditions. We believe the results have implications for isolation design and standards development. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wilder, D AU - Xia, T AU - Ankrum, J AU - Spratt, K Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - Vibration KW - Muscles KW - Stress KW - Ergonomics KW - Working conditions KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilder%2C+D%3BXia%2C+T%3BAnkrum%2C+J%3BSpratt%2C+K&rft.aulast=Wilder&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seated+human+response+to+simple+and+complex+impacts&rft.title=Seated+human+response+to+simple+and+complex+impacts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Perception thresholds for lateral vibration at the hand, seat, and foot AN - 19392627; 7157569 AB - Discomfort, annoyance, or interference with activities due to exposure to vibration is only expected if the vibration exceeds the threshold for the perception of vibration. When there is more than one vibration input to the body (e.g. at the hands, seat and feet), the sensation is first experienced at the location with greatest sensitivity. Knowledge of differences in the thresholds of perception for vibration at the hand, seat, and feet should assist the identification of sources of discomfort caused by vibration. Perception thresholds for vibration have been determined in several studies, but only a few studies have investigated perception thresholds in the horizontal direction for hand-transmitted vibration or whole-body vibration, and there has been little consideration of perception thresholds for the foot resting on a vibrating surface. This study determines absolute thresholds for the perception of sinusoidal lateral vibration, examining the effect of vibration frequency (8 to 315 Hz for the hand and foot; 2 to 315 Hz for the seat) and the effect of input location (the hand, the seat and the foot). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Morioka, M AU - Griffin, MJ Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Perception KW - Vibration KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Morioka%2C+M%3BGriffin%2C+MJ&rft.aulast=Morioka&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Perception+thresholds+for+lateral+vibration+at+the+hand%2C+seat%2C+and+foot&rft.title=Perception+thresholds+for+lateral+vibration+at+the+hand%2C+seat%2C+and+foot&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Challenges and uncertainties in designing field studies to measure hand vibration AN - 19392604; 7157564 AB - We encountered several areas of methodologic uncertainty during development of a data collection method for use with vibrating hand tools in metal assembly. A local manufacturer sought our assistance designing a data collection method for evaluating and predicting risks of upper extremity disorders associated with use of vibrating hand tools. Current methods of vibration measurement are described in ISO 5349 [2]. However, the complexity of measuring vibration along with other exposures such as force and posture has limited the number of workplace-based studies of upper extremity disorders that have included direct measurements of vibration. Data from this preliminary study was used to look at two issues: a comparison of vibration values between production and non-production workers when performing the same task, and a comparison of worker ratings of vibration comfort to direct measurement of tool vibration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dale, A M AU - Standeven, J AU - Evanoff, B Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Data collection KW - Conferences KW - Vibration KW - musculoskeletal system KW - hand tools KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dale%2C+A+M%3BStandeven%2C+J%3BEvanoff%2C+B&rft.aulast=Dale&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Challenges+and+uncertainties+in+designing+field+studies+to+measure+hand+vibration&rft.title=Challenges+and+uncertainties+in+designing+field+studies+to+measure+hand+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Railroad locomotive whole-body vibration study: Vibration, shocks and seat ergonomics AN - 19392514; 7157618 AB - North American railroad locomotive operators (engineers and conductors) are exposed to multi-axis vibration and shocks. A recent epidemiological survey showed a prevalence of serious type of neck and lower back disorders nearly double that of a control group. Ergonomic working conditions are important co-factors in a vibration and shock exposure risk assessment The goal of this study is to illustrate typical work stations (cabs and seats) in US/Canadian type locomotives and assess shock related exposure risk by calculations of the new proposed shock risk indicators according to the new ISO 2631-5 (2004). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Johanning, E AU - Fischer, S AU - Christ, E AU - Gores, B AU - Luhrman, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - locomotives KW - Vibration KW - Railroads KW - working conditions KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johanning%2C+E%3BFischer%2C+S%3BChrist%2C+E%3BGores%2C+B%3BLuhrman%2C+R&rft.aulast=Johanning&rft.aufirst=E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Railroad+locomotive+whole-body+vibration+study%3A+Vibration%2C+shocks+and+seat+ergonomics&rft.title=Railroad+locomotive+whole-body+vibration+study%3A+Vibration%2C+shocks+and+seat+ergonomics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Instrumented handles for studying hand-transmitted vibration exposure AN - 19392473; 7157614 AB - Instrumented handles or dynamometers are widely used to measure hand forces and/or the biodynamic response of hand-arm system. To study hand-transmitted vibration exposure, six generations of instrument handles were constructed or initially developed by researchers in ECTB/HELD/NIOSH. This presentation provided a summary of these handles. Their basic characteristics, limitations, and usefulness are described, which may help their appropriate applications and further improvements. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Welcome, DE AU - Dong, R G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Occupational exposure KW - Working conditions KW - Hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Welcome%2C+DE%3BDong%2C+R+G&rft.aulast=Welcome&rft.aufirst=DE&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Instrumented+handles+for+studying+hand-transmitted+vibration+exposure&rft.title=Instrumented+handles+for+studying+hand-transmitted+vibration+exposure&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Investigation into the uncertainty in measurements and evaluation of hand-transmitted vibration AN - 19392449; 7157592 AB - Accurate measurement and evaluation of hand-transmitted vibration from a power tool is an important issue for tool manufacturers, because they are obliged to develop low-hazard power tools for workers. The International Standard ISO 5349 dictates a systematic procedure for the measurement and evaluation of hand-transmitted vibration. However, the uncertainty in this measurement is too large for manufacturers to apply such data to the design and modification of power tools. There can be several sources of this uncertainty in such measurements; e.g., operator-dependent, power tool-dependent, and operational conditions For a manufacturer to characterize the exposure of a power tool's use to a given level of vibration, the relationship between these uncertainty factors and the measured vibration must be elucidated. In this study, we investigated the effect of several factors on the uncertainty in measurements. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jang, H-K AU - Song, C-M AU - Hong, S-I AU - Choi, S-H Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jang%2C+H-K%3BSong%2C+C-M%3BHong%2C+S-I%3BChoi%2C+S-H&rft.aulast=Jang&rft.aufirst=H-K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Investigation+into+the+uncertainty+in+measurements+and+evaluation+of+hand-transmitted+vibration&rft.title=Investigation+into+the+uncertainty+in+measurements+and+evaluation+of+hand-transmitted+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Device for measuring daylong vibration exposure and grip force levels for during hand-tool use AN - 19392392; 7157563 AB - Over the past two decades, there have been significant reductions in industrial exposures to hand-arm vibration, especially when specific tools and work processes have been redesigned to incorporate anti-vibration and ergonomic principles. Nevertheless, Hand-Arm Vibration Syndrome (HAVS) remains a significant occupational health problem as disease symptoms continue to occur even when vibration exposure levels believed to incur low risks have been reached. This inconsistency may be related to the methodology that is typically used to estimate workday vibration exposure levels, involving laboratory and/or very short duration field measurements coupled with estimates of overall eight-hour tool operation times determined from brief observations of tool tasks and/or self-reported surveys. One solution is to use small, commercially-available, personal vibration dosimeters to calculate, record, and display long-duration vector sums and energy equivalents of vibration. However, since these devices are attached to the worker and require tool-mounted accelerometers, they are incompatible with the worker performing normal duties involving putting down or changing tools. In addition, these commercial systems do not allow for the characterization of the transmission of vibration to the hand such as monitoring the mechanical coupling between the hand and the tool handle (e.g., grip forces). O'Boyle and Griffin showed that variations in applied force can alter vibration transmission characteristics by 50% or more indicating that the measurement of grip force is essential for modeling vibration transmissibility and vibration exposures. In summary, a need exists for the development of a method and device that will more accurately characterize workday-long vibration exposures. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Peterson AU - Brammer, A J AU - Cherniack, M G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - Ergonomics KW - working conditions KW - Hand tools KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Peterson%3BBrammer%2C+A+J%3BCherniack%2C+M+G&rft.aulast=Peterson&rft.aufirst=&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Device+for+measuring+daylong+vibration+exposure+and+grip+force+levels+for+during+hand-tool+use&rft.title=Device+for+measuring+daylong+vibration+exposure+and+grip+force+levels+for+during+hand-tool+use&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Time-frequency analysis of hand-transmitted vibration of impact tools using analytic wavelet transform AN - 19392361; 7157561 AB - Prolonged, extensive exposure to hand-transmitted vibration could cause a series of vibration-induced disorders in the vascular, sensorineural, and musculoskeletal structures of the human hand-arm system, which have been collectively called hand-arm vibration syndrome (HAVS). To assess the risk of HAVS the international standard ISO 5349-1 (2001) recommends using the root-mean-square (rms) acceleration of the measured vibration with a frequency weighting. While a few epidemiological studies have reported results consistent with the predictions made according to the recommendation, many other studies have reported results with large discrepancies. This may be partially attributed to the time-averaging effect involved in calculation of the frequency components, especially for impact type tools. Because the spectral characteristics of impact tools change dramatically with time, a time-frequency (T-F) analysis can provide better characterizations of such highly transient vibrations. The analytic wavelet transform (AWT) is an ideal T-F analysis tool because it possesses the advantages of both the Fourier transform and the wavelet transform. The objective of this study was to explore the application of the AWT method for characterizing the impact tool vibrations and assessing their exposure risk. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kim, J AU - Welcome, DE AU - Dong, R G AU - Song, W J AU - Hayden, C Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - musculoskeletal system KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kim%2C+J%3BWelcome%2C+DE%3BDong%2C+R+G%3BSong%2C+W+J%3BHayden%2C+C&rft.aulast=Kim&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Time-frequency+analysis+of+hand-transmitted+vibration+of+impact+tools+using+analytic+wavelet+transform&rft.title=Time-frequency+analysis+of+hand-transmitted+vibration+of+impact+tools+using+analytic+wavelet+transform&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Revision of ANSI S3.34 (2.70-2006) - guide for the measurement and evaluation of human exposure to vibration transmitted to the hand AN - 19391811; 7157588 AB - Intense vibration can be transmitted to the hands and arms of workers who use hand-held percussive or vibrating devices, tools, and work pieces. Continued habitual exposure to vibration directed to the hands can cause patterns of various symptoms associated with hand-arm vibration syndrome (HVAS). The International Organization for Standardization (ISO) first published ISO 5349 in 1986. This standard specified methods for measuring and evaluating vibration directed into the hands from hand-held vibrating devices, tools, and work pieces. The American National Standards Institute (ANSI) published ANSI S3.34 the same year. This standard was modeled after ISO 5349-1986 and specified methods for assessing exposure to hand-arm vibration. The Parliament of the European Union has issued the European Union Human Vibration Directive-2002/44/EC, which specifies vibration daily exposure action values (DEAV) of 2.5 m/s super(2) and daily exposure limit values (DELV) of 5.0 m/s super(2). These values have generally been accepted by medical experts, scientists, and engineers in governmental agencies, research institutions, and industry in the USA and other countries. When they are achieved, they will reduce the potential for the development of symptoms related to HAVS among workers exposed to hand-arm vibration. Significant improvements in measurement and analysis instrumentation, miniature and subminiature accelerometers, and medical diagnostic and assessment protocols have being introduced since 1986 when ANSI S3.34 was first published. In response to these improvements and the introduction of the EU Human Vibration Directive, ANSI Working Group S2.39 developed the revision to ANSI S3.34, which has now been published as ANSI S2.70-2006. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Reynolds, D D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - European Union KW - Vibration KW - Standards KW - hand-arm vibration syndrome KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reynolds%2C+D+D&rft.aulast=Reynolds&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Revision+of+ANSI+S3.34+%282.70-2006%29+-+guide+for+the+measurement+and+evaluation+of+human+exposure+to+vibration+transmitted+to+the+hand&rft.title=Revision+of+ANSI+S3.34+%282.70-2006%29+-+guide+for+the+measurement+and+evaluation+of+human+exposure+to+vibration+transmitted+to+the+hand&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Shock and impact on North American locomotives evaluated with ISO 2631 Parts 1 and 5 AN - 19391784; 7157587 AB - The International Organization for Standardization (ISO) standard ISO 2631 provides three methods for evaluation of human exposure to vibrations that contain occasional shocks or impacts. Part 1 of the standard specifies the running r.m.s. or maximum transient vibration method (MTVV) and the fourth power vibration dose value (VDV). Part 5 of the standard provides a method of computing the stress in the lumbar spine for humans exposed to multiple shocks. Alem et al have reported application of these methods to data for tactical ground vehicles. This paper reports and compares VDV and spinal stress evaluations of more than 90 hours of vibration and shock measurements on North American locomotives engaged in through freight operations. The measurements evaluated in this paper were obtained for full crew shifts on 19 freight locomotive runs on mainline track in locations from New York to California. The shifts ranged in duration from 187 minutes to 497 minutes. The average speeds for the shifts were from 21.0 mph to 54.6 mph. All measurements were made on locomotives hauling freight trains in regular revenue service. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Cooperrider, N K AU - Gordon, J J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - spine KW - locomotives KW - Conferences KW - Vibration KW - Stress KW - Standards KW - USA, California KW - USA, New York KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cooperrider%2C+N+K%3BGordon%2C+J+J&rft.aulast=Cooperrider&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Shock+and+impact+on+North+American+locomotives+evaluated+with+ISO+2631+Parts+1+and+5&rft.title=Shock+and+impact+on+North+American+locomotives+evaluated+with+ISO+2631+Parts+1+and+5&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Acute vibration exposure shifts the current perception threshold of A beta fibers in a rat tail model of vibration AN - 19391751; 7157580 AB - Occupational exposure to hand-arm vibration through the use of powered hand tools can result in reductions in tactile sensitivity, grip strength and manual dexterity. In fact, even acute exposures to vibration cause shifts in vibrotactile thresholds in exposed fingers. Although reductions in tactile sensitivity after acute vibration exposures are transient, cellular changes associated with this shift in sensitivity could lead to the more permanent reductions in tactile sensitivity that are a common symptom of hand-arm vibration syndrome (HAVS). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Perception KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Krajnak%2C+K+M&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Acute+vibration+exposure+shifts+the+current+perception+threshold+of+A+beta+fibers+in+a+rat+tail+model+of+vibration&rft.title=Acute+vibration+exposure+shifts+the+current+perception+threshold+of+A+beta+fibers+in+a+rat+tail+model+of+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Dynamic responses of a fingertip to vibration - 3D finite element analysis AN - 19391700; 7157573 AB - Although the exact mechanisms underlying vibration white finger (VWF) are not clear, it has been speculated that VWF is associated with variations of the blood flow patterns due to the physical damage and/or degeneration in neural and vascular tissue caused by vibration loading. Excessive dynamic deformation of the soft tissues in the fingertip under vibration loading is believed to induce multiple occupation-related hand/finger disorders. However, the in vivo distributions of the dynamic stress/strain of the tissues in the fingertip under vibration conditions have not been studied because they cannot be measured experimentally to date. The goal of this study is to analyze, theoretically, the location and frequency-dependent dynamic deformation of the soft tissue in the fingertip during vibration exposures. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wu, J Z AU - Krajnak, K AU - Welcome, DE AU - Dong, R G Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Blood KW - Vibration KW - Stress KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wu%2C+J+Z%3BKrajnak%2C+K%3BWelcome%2C+DE%3BDong%2C+R+G&rft.aulast=Wu&rft.aufirst=J&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Dynamic+responses+of+a+fingertip+to+vibration+-+3D+finite+element+analysis&rft.title=Dynamic+responses+of+a+fingertip+to+vibration+-+3D+finite+element+analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Musculoskeletal symptoms among operators of heavy mobile equipment AN - 19390849; 7157609 AB - The purpose of this study was to assess the adequacy of the cab design and to determine the percentage of musculoskeletal symptoms among operators of mobile equipment used in mining and construction. A questionnaire was designed to assess demographics, work information, job history, and musculoskeletal symptoms in operators of heavy mobile equipment. Information concerning equipment included design of the seat/chair, levers, pedals, bothersome vibration, quality of ingress/egress from the equipment, proper preventative maintenance and repairs, and age of the equipment. The body regions that were evaluated included the neck, middle/upper back, low-back, shoulder/upper-arm, elbow/forearm, wrist/hand, hip, knee, and ankle/foot. Five hundred and eighty six operators completed the questionnaire. The results indicate that these workers are at risk for developing musculoskeletal disorders, and the need to quantify risk factors (i.e., whole-body vibration and static sitting postures). JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Kittusamy, N K Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Conferences KW - Vibration KW - musculoskeletal system KW - Maintenance KW - Occupational exposure KW - Working conditions KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kittusamy%2C+N+K&rft.aulast=Kittusamy&rft.aufirst=N&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Musculoskeletal+symptoms+among+operators+of+heavy+mobile+equipment&rft.title=Musculoskeletal+symptoms+among+operators+of+heavy+mobile+equipment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Health perception in workers exposed to hand-arm vibration: Prerequisite for putting in place an effective preventive program in the workplace AN - 19390800; 7157586 AB - Knowledge of risks from exposure to hand-arm vibrations is usually presented by clinicians and researchers from a medical and engineering point of view. There is a strong need to develop innovative health promotion programs for exposed workers. Risk perceptions by vibration exposed workers and HAVS (hand-arm vibration syndrome) affected workers are less well known. In 1983, Brubaker demonstrated that 75% of studied fellers thought that whitening of the fingers was part of the job and/or an unrelated nuisance, while only 25% believed it was a disease. Grounds also showed that even though there were a very high number of forestry workers with white fingers, none considered quitting because of their condition. It seems that many workers hesitate to declare the illness or believe they are less affected than they really are, perhaps from fear of losing their jobs and livelihood. Risk awareness, on the part of exposed workers and their employers, as well as knowledge and acceptance of available preventive solutions are necessary steps before installing adequate preventive measures, whether organizational, behavioral or environmental. Workers need to understand fully the hazards and risks in order to be able to make informed decisions under uncertain conditions. Prerequisites include the following: workers knowledge about the risk, their attitude towards it, which in turn, can be influenced by values, needs and interests. Also, knowledge and attitudes towards safety behaviour, organizational or environmental barriers must be taken into account. Our research focuses on these key elements, which help bridge the gap between health promotion research and practice. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Turcot, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - safety engineering KW - Perception KW - Vibration KW - hand-arm vibration syndrome KW - health promotion KW - Occupational exposure KW - Forestry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Turcot%2C+A&rft.aulast=Turcot&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+perception+in+workers+exposed+to+hand-arm+vibration%3A+Prerequisite+for+putting+in+place+an+effective+preventive+program+in+the+workplace&rft.title=Health+perception+in+workers+exposed+to+hand-arm+vibration%3A+Prerequisite+for+putting+in+place+an+effective+preventive+program+in+the+workplace&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The effects of vibration on psychophysical grip and push force-recall accuracy AN - 19390755; 7157566 AB - Workers using vibrating hand tools have the potential for developing health problems associated with repeated forceful actions and exposures to hand-transmitted vibration. Hand-arm vibration syndrome (HAVS) and other hand-arm system disorders have been associated with such exposures. To better assess health risks, comprehensive evaluations of these exposures must include quantitative assessments of hand-tool coupling forces; unfortunately, no standardized method for quantifying hand forces exists. Handle instrumentation may be ill-suited for some field environments. Psychophysical force-recall techniques may provide alternatives to handle instrumentation. A thorough understanding of the effects of vibration and other factors on force-recall accuracy and reliability is important before such methods are applied in risk assessments. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - McDowell, T W AU - Wiker, S F AU - Dong, R G AU - Welcome, DE Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Conferences KW - Vibration KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McDowell%2C+T+W%3BWiker%2C+S+F%3BDong%2C+R+G%3BWelcome%2C+DE&rft.aulast=McDowell&rft.aufirst=T&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+effects+of+vibration+on+psychophysical+grip+and+push+force-recall+accuracy&rft.title=The+effects+of+vibration+on+psychophysical+grip+and+push+force-recall+accuracy&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Ride motion effects on the accuracy of rapid pointing tasks AN - 19390713; 7157565 AB - Reaching movements are planned and subsequently executed using visual and somatosensory feedbacks where absence of visual feedback is known to increase endpoint variability. Visual occlusion decreases the ability to make rapid online compensatory movements, which results in initial radial deviations that are highly correlated with radial dispersion at the target. Perturbations of rapid, visually-guided reaches are compensated on-line and result in endpoint dispersions poorly correlated with initial deviations, emphasizing the strong effect of visual feedback in temporally-constrained reaching tasks. In control conditions (no vibration), these uncompensated, rapid reaches serve as estimates of the individual's intended trajectory. When ride motion is present, trajectories of rapid, visually-occluded reaches provide a measure of the natural biodynamic response of the cantilevered spine-arm-hand linkage. These intended movement trajectories and the biodynamic response (vibration feedthrough) are used to predict the effect of ride motion on the performance of rapid reaching tasks. Goals of this study are to investigate the influences of vehicle motion on human reaching and pointing, and to reveal movement strategies used in visually-occluded reaching tasks. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Rider, KA AU - Martin, B J Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - Materials handling KW - Working conditions KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rider%2C+KA%3BMartin%2C+B+J&rft.aulast=Rider&rft.aufirst=KA&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ride+motion+effects+on+the+accuracy+of+rapid+pointing+tasks&rft.title=Ride+motion+effects+on+the+accuracy+of+rapid+pointing+tasks&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A field study: Measurement and evaluation of whole body vibration for MH-60S pilots AN - 19390123; 7157616 AB - Pilots of the MH-60S helicopter are exposed to continuous whole body vibration (WBV). Pilot fatigue is a growing operational concern due to the increased frequency of extended durations of missions (6-8+hours) in support of Operations Iraqi Freedom and Enduring Freedom. Endurance aspects of the currently used rotary wing seating systems were not optimized for the longer missions and wide range of pilot anthropometric measurements, which is now typical of naval aviation. The current seating systems were designed primarily to meet crashworthiness requirements, not for the wide range of pilot anthropometry or to mitigate WBV. Albeit, an issue, pilot fatigue and reduced mission effectiveness are also critical concerns. Current Hazard Reports indicated that pain in pilots' legs and backs begin two to four hours into the flight and increase with time. Mission readiness also decreases with an increase in flight duration due to the constant distraction of pilots shifting in their seats while trying to get comfortable. Froom, et al reported a dose-response relationship between the length of military helicopter flights and back discomfort. He also concluded that this pain is typically dull, over the lower back, and its prevalence and intensity are dependent on the total flight hours of exposure. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Harrer, K AU - Estrada, N AU - Lavery, C AU - Nowell, J AU - Jennings, C AU - Yniguez, D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - crashworthiness KW - Vibration KW - Dose-response effects KW - pain KW - Military KW - helicopters KW - fatigue KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Harrer%2C+K%3BEstrada%2C+N%3BLavery%2C+C%3BNowell%2C+J%3BJennings%2C+C%3BYniguez%2C+D&rft.aulast=Harrer&rft.aufirst=K&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+field+study%3A+Measurement+and+evaluation+of+whole+body+vibration+for+MH-60S+pilots&rft.title=A+field+study%3A+Measurement+and+evaluation+of+whole+body+vibration+for+MH-60S+pilots&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Seat cushion and posture effects in military propeller aircraft vibration environments AN - 19390060; 7157598 AB - Annoyance, fatigue, and musculoskeletal pain have been reported during prolonged exposures to propulsion-generated vibration in military propeller aircraft. The objective of this study was to determine the vibration mitigation properties of selected seat cushions and the effects of occupant seating posture during exposure to higher frequency multi-axis vibration associated with military propeller aircraft. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Smith, S D AU - Smith, JA Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Aircraft KW - Vibration KW - pain KW - Military KW - Occupational exposure KW - musculoskeletal system KW - fatigue KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Smith%2C+S+D%3BSmith%2C+JA&rft.aulast=Smith&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seat+cushion+and+posture+effects+in+military+propeller+aircraft+vibration+environments&rft.title=Seat+cushion+and+posture+effects+in+military+propeller+aircraft+vibration+environments&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of scraper operator exposure to whole-body vibration in the construction industry: A task analysis AN - 19390038; 7157590 AB - Kittusamy (Kittusamy & Buchholz, 2004) state that there have been few studies conducted to assess exposure to whole-body vibration (WBV) in the construction industry. They suggest that there is very little reliable data from the construction industry that characterizes exposure levels to various hazards including WBV or the health outcomes from such exposure and that there is a need for more exposure data. In a recent exploratory study of heavy construction equipment Cann (Cann, Salmoni, Vi, & Eger, 2003) looked at vibration levels for 14 different types of construction equipment. Eight of the 14 pieces of equipment tested exposed operators to levels of WBV that exceeded the recommended limits for an 8-hour period when comparing the measured VDV to the ISO 2631-1 standards. The purpose of the present research was not only to test a larger number of scrapers but also to investigate scraper operator exposure to whole body vibration (WBV) separately for each task. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Gillin, E K AU - Cannl, A AU - Vi, P AU - Eger, T AU - Hunt, M AU - Salmoni, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Salmonidae KW - Construction industry KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gillin%2C+E+K%3BCannl%2C+A%3BVi%2C+P%3BEger%2C+T%3BHunt%2C+M%3BSalmoni%2C+A&rft.aulast=Gillin&rft.aufirst=E&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+scraper+operator+exposure+to+whole-body+vibration+in+the+construction+industry%3A+A+task+analysis&rft.title=Evaluation+of+scraper+operator+exposure+to+whole-body+vibration+in+the+construction+industry%3A+A+task+analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Standard tests for suspended seats - can these contribute to protection against whole-body vibration? - commentary on historical development and current work in CEN/TC231/WG9 (Seating) AN - 19390013; 7157589 AB - Suspended seats perform two functions: Reduce effect of occasional large bumps; Reduce more continuous vibration at a lower level. The former needs high damping. The latter needs low damping. For most mobile work machines the inevitable compromise is generally better than a simple cushion seat, because that amplifies vibration at around 4 Hz which is a sensitive frequency for human vertical WBV. Why have standard tests for seat suspensions? Seat suspensions are non-linear so any measure of performance depends on operating conditions. For comparison these need to be defined. Seat manufacturers need benchmarks for product development; Machine makers choose dynamic characteristics appropriate to their products; Occupational health specialists wish to control operator exposure to Standard tests should be representative, repeatable and reproducible. These requirements are reviewed in relation to the history of seat test standards and the current position. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Stayner, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Vibration KW - Reviews KW - Standards KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stayner%2C+R&rft.aulast=Stayner&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Standard+tests+for+suspended+seats+-+can+these+contribute+to+protection+against+whole-body+vibration%3F+-+commentary+on+historical+development+and+current+work+in+CEN%2FTC231%2FWG9+%28Seating%29&rft.title=Standard+tests+for+suspended+seats+-+can+these+contribute+to+protection+against+whole-body+vibration%3F+-+commentary+on+historical+development+and+current+work+in+CEN%2FTC231%2FWG9+%28Seating%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Hand force-dependent modeling of the hand-arm under Z sub(H)-axis vibration AN - 19389969; 7157572 AB - A number of biodynamic models of the hand-arm system have evolved on the basis of measured driving-point mechanical impedance (DPMI) responses to facilitate analyses of the coupled hand-tool system. The parameter identifications in such models are based upon minimization of an error function of the model and the target impedance data, which may not yield a unique solution. Consequently, a number of model structures and parameter sets could be realized that would equally satisfy the target curve. Moreover, the vast majority of the reported models exhibit acute deficiencies due to excessive static deflections of model masses, presence of a low frequency mode and very light masses in the order of 1.2- 4.8 grams. The models also do not characterize the dependency of the biodynamic responses on many factors, namely the hand forces, hand-arm posture and vibration intensity. This study aims at development of a hand-arm biodynamic model with considerations of the hand forces, and both the DPMI and power absorption measures, to enhance the uniqueness of the model. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Aldien, Y AU - Rakheja, S AU - Marcotte, P AU - Boileau, P-E Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Absorption KW - Occupational exposure KW - Working conditions KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Aldien%2C+Y%3BRakheja%2C+S%3BMarcotte%2C+P%3BBoileau%2C+P-E&rft.aulast=Aldien&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hand+force-dependent+modeling+of+the+hand-arm+under+Z+sub%28H%29-axis+vibration&rft.title=Hand+force-dependent+modeling+of+the+hand-arm+under+Z+sub%28H%29-axis+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A method of evaluating vehicle seat vibration with consideration of subjective judgment AN - 19389945; 7157568 AB - Vibration magnitude and frequency of the z-axis vehicle seat are time-variant, which are influenced by not only vehicle vibration characteristics themselves but also road surfaces, speeds and the human body. There is little in the current reporting about evaluating and analyzing automobile seat vibration that focuses on the time-variant. Yaguchi et al. has proposed a method to evaluate automobile seat vibration that is based on judgments using a subjective mental state. Their method focuses on the time-variant magnitude of the peak frequency on a power spectrum density. However, their method has no consideration of all the frequency contents of the discomfort, nor comparison between different peak frequency vibrations. Suzuki has emphasized that the vehicle vibration should be judged by a series of vibration stimuli to evaluate, because the vehicle vibration is time-variant, which isn't a matter of the relationship between a single vibration stimulus and a subjective response. He clarified that the human sensation to the vehicle vibration discomfort changes every moment showing the relationship between the frequency-weighted r.m.s. acceleration calculated every 5 seconds and the category judgment to vehicle vibration discomfort every 5 seconds. However, his study doesn't show what parameter connects to the subjective final judgment to vehicle vibration. Therefore, we applied the method similar to ISO 10056 considering the time-variant to the vehicle seat z-axis vibration evaluation. The new method for the vehicle seat vibration considering the time-variant was examined on the hypothesis that the final subjective evaluation must be conducted from the judgment summarizing a series of vibration stimuli. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Nakashima, Y AU - Maeda, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Motor vehicles KW - Highways KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Nakashima%2C+Y%3BMaeda%2C+S&rft.aulast=Nakashima&rft.aufirst=Y&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+method+of+evaluating+vehicle+seat+vibration+with+consideration+of+subjective+judgment&rft.title=A+method+of+evaluating+vehicle+seat+vibration+with+consideration+of+subjective+judgment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Effects of repeated vibration exposures in muscle tissue AN - 19389668; 7157620 AB - Workers exposed to vibrating hand tools are at risk of developing symptoms such as cold-induced vasospasms, loss of tactile sensitivity, and loss of grip strength in the fingers and hands. These symptoms are known collectively as vibration white finger (VWF) or hand-arm vibration syndrome (HAVS). Symptoms of VWF or HAVS are in part due to repeated and prolonged peripheral vasoconstriction. The reduction in blood flow that occurs with vasoconstriction can result in oxygen deprivation (hypoxia) in soft tissues, such as nerves and muscle, and lead to functional and structural changes in these tissues. The present study examined muscle tissue to determine if vibration-induced changes in transcript levels and protein concentrations result in enhanced vasoconstriction and hypoxia. Manual dexterity was also assessed intermittently to determine if vibration-induced changes in cellular factors are accompanied by performance deficits. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Wirth, O AU - Waugh, S AU - Johnson, C AU - Miller, G R AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Oxygen KW - Vibration KW - Hypoxia KW - Muscles KW - Proteins KW - hand-arm vibration syndrome KW - Occupational exposure KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wirth%2C+O%3BWaugh%2C+S%3BJohnson%2C+C%3BMiller%2C+G+R%3BKrajnak%2C+K+M&rft.aulast=Wirth&rft.aufirst=O&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Effects+of+repeated+vibration+exposures+in+muscle+tissue&rft.title=Effects+of+repeated+vibration+exposures+in+muscle+tissue&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Vibration emission measurement methods for Grinders AN - 19389623; 7157601 AB - ISO8662-4, "Hand-held portable power tools - Measurement of vibrations at the handle -Part 4: Grinders" is under revision. The new revision shall harmonize ISO 20643 "Mechanical vibration - Hand-held and hand-guided machinery - Principles for evaluation of vibration emission" which, among others, requires measurements in three directions and declared values related to the upper quartile of real-use vibration. To get the most suitable test method, a round robin test was made for evaluation of the two test methods proposed by the ad-hoc group working with this standard revision. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Persson, M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Machinery KW - Emission measurements KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Persson%2C+M&rft.aulast=Persson&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Vibration+emission+measurement+methods+for+Grinders&rft.title=Vibration+emission+measurement+methods+for+Grinders&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A novel 3-D hand-arm vibration test system and its preliminary evaluations AN - 19389598; 7157596 AB - Vibration exposure at workplaces is generally multi-axial. The health effects of vibration exposure also likely depend on the vibration direction. Therefore, there is a wide interest in the simulation of multi-axial vibration in laboratory experiments. Advances in technology have led to the development of a new 3-D test system for studying hand-transmitted vibration exposure and health effects. The purposes of this paper are to introduce the system and to present the results of its preliminary evaluations. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Dong, R G AU - Welcome, DE AU - McCormick, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - Simulation KW - Occupational exposure KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BMcCormick%2C+R&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+novel+3-D+hand-arm+vibration+test+system+and+its+preliminary+evaluations&rft.title=A+novel+3-D+hand-arm+vibration+test+system+and+its+preliminary+evaluations&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A case study of whole-body vibration exposures associated with ordinary passenger and recreational vehicles AN - 19389579; 7157576 AB - Measurements and analyses were conducted of whole-body vibration aboard seven commercially available passenger and/or recreational vehicles: sedan; sport-utility vehicle (SUV); pickup truck; moving truck; motorcycle; all-terrain vehicle (ATV); and boat. The purpose of the testing was to measure and assess whole-body vibration exposure in a range of typical vehicle environments in order to gain understanding of typical exposure levels characteristic of activities of daily living. Vehicle models tested (and model year) were: Ford Taurus (1995); Jeep Cherokee Sport (2000); Toyota Tundra SR5 (2002); Ford F-350 (1997); Harley-Davidson Electra Glide Classic (2004); Yamaha Kodiak 400 4x4; and Steiger Craft Model 21 Montauk. All vehicles were tested with their standard factory-installed seats and were operated under a range of normal operating conditions and speeds typical of intended vehicle use. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Gibson, R G AU - Gibbons, J D Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, New York, Long I., Montauk KW - Recreation areas KW - all-terrain vehicles KW - Electra KW - Vibration KW - Motor vehicles KW - boats KW - Trucks KW - Motorcycles KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gibson%2C+R+G%3BGibbons%2C+J+D&rft.aulast=Gibson&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+case+study+of+whole-body+vibration+exposures+associated+with+ordinary+passenger+and+recreational+vehicles&rft.title=A+case+study+of+whole-body+vibration+exposures+associated+with+ordinary+passenger+and+recreational+vehicles&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Handle design for optimal hand function AN - 19388820; 7157622 AB - Tubular Handles can negatively affect the contents of the carpal tunnel Years of injuries from grasping handles for tools and machines can cause carpal tunnel syndrome, tendonitis and wrist joint injuries. The can cause inability to use a hand and resulted in the longer absences from work than injuries from falls, accidents or fires. Cylindrical, tubular and rectangular handles are rolled flat structures. They place the hand on a rolled flat surface where the ends of the middle and ring fingers overlap the index and small fingers. They are pulled along a series of lines that contact the end joint of the index finger, the middle bones of the middle and ring fingers and the end bone of the small finger. Cylinders are pulled diagonally in the hand toward the carpal tunnel (CT) area. Gripping in this manner tenses asymmetric muscle groups in the forearm. Handles could work better if they do not place pressure on the CT and conform to the natural function or neutral hand position where the hand rests or dangles at the side of the body, the finger tips form a diagonal, the palm and fingers form a cup, the thumb rests between the index and middle fingers and the wrist is mildly extended. However, handles designed for the neutral position are pulled by diagonally oriented fingers into the valley between the thenar and hypothenar muscles where they can compress the median nerve and tendons exiting the CT. Seven principles for handles that do not place pressure on the carpal tunnel and employ optimal hand position are presented. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Tillim, S L Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Bone KW - Accidents KW - Injuries KW - Conferences KW - Vibration KW - carpal tunnel syndrome KW - Occupational safety KW - overuse injuries KW - Muscles KW - Design KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Tillim%2C+S+L&rft.aulast=Tillim&rft.aufirst=S&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Handle+design+for+optimal+hand+function&rft.title=Handle+design+for+optimal+hand+function&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Use of tungsten to reduce vibration exposure in aircraft manufacturing AN - 19388794; 7157621 AB - Riveting operations in aircraft manufacturing involves the use of power tools for manually drilling holes for the rivets, power drills for the setting of the holes for the rivets, as well as rivet guns to drive and set the rivets. To close the rivet, the rivet is driven against a metallic bar commonly called a "bucking bar". The bucking bars are typically held firmly to increase the quality of the riveting, as well as keep the bucking bar from "dancing" against the metal piece being riveted. Thus, employees in aircraft manufacturing involved in riveting are exposed to hand-arm vibration from several sources, and epidemiological evidence suggests that vibration-related musculoskeletal disorders are associated with long term exposure to riveting tasks in the aircraft manufacturing of aircraft. Recently, tungsten technology has been introduced into aircraft manufacturing for bucking bars, which are heavier than traditional steel bucking bars of the same size. Rivet guns with tungsten pistons instead of steel pistons have also recently been introduced with the objective of reducing vibration exposure to the riveter. The objective of this study was to assess vibration characteristics of steel and tungsten bucking bars and rivet guns to identify the combination that simultaneously reduced the combined exposure to both the "riveter" and "bucker". JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Jorgensen, MJ AU - Khan, K S AU - Polsani, A Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Aircraft KW - Conferences KW - Vibration KW - Steel KW - Occupational exposure KW - musculoskeletal system KW - Tungsten KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jorgensen%2C+MJ%3BKhan%2C+K+S%3BPolsani%2C+A&rft.aulast=Jorgensen&rft.aufirst=MJ&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+tungsten+to+reduce+vibration+exposure+in+aircraft+manufacturing&rft.title=Use+of+tungsten+to+reduce+vibration+exposure+in+aircraft+manufacturing&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Measuring physiological and biochemical changes in work-related vibration AN - 19388026; 7157579 AB - Until now there has been controversy about which tests should be performed to diagnose early Hand-Arm Vibration Syndrome (HAVS). Initial screening questions, especially about tingling and numbness, routinely given to patients prior to examinations proved to be a very important tool in the diagnostic process. However, standardized tests that are simple, quick, valid and reliable are needed to support a diagnosis of HAVS. Purpose: To find the most valid and reliable tests to diagnose HAVS. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Yan, J-G AU - Matloub, H S AU - Zhang, L-L AU - Sanger, J R AU - Yan, Y AU - Riley, DA AU - Agresti, M AU - Rowe, D AU - Galaviz, P AU - Marchant-Hanson, J AU - Lifchez, S Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Conferences KW - Vibration KW - Physiology KW - hand-arm vibration syndrome KW - Occupational exposure KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Yan%2C+J-G%3BMatloub%2C+H+S%3BZhang%2C+L-L%3BSanger%2C+J+R%3BYan%2C+Y%3BRiley%2C+DA%3BAgresti%2C+M%3BRowe%2C+D%3BGalaviz%2C+P%3BMarchant-Hanson%2C+J%3BLifchez%2C+S&rft.aulast=Yan&rft.aufirst=J-G&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Measuring+physiological+and+biochemical+changes+in+work-related+vibration&rft.title=Measuring+physiological+and+biochemical+changes+in+work-related+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Prospective studies of vibration exposed cohorts: Hand-arm vibration international consortium (HAVIC) AN - 19388006; 7157577 AB - HAVIC is a collaboration of investigators from North America, Sweden, and Finland having a scientific mandate from NIOSH, to study the exposure response relationship between vibratory tool exposure and adverse health effects. Five cohorts, the Suomossalmi forest workers cohort, Volvo truck cab workers, Connecticut shipyard workers, and matriculating dental hygiene students and experienced dental hygienists have been under study. In the case of shipyard workers, there was survey and tool exposure data from 1988, although detailed subject testing was only available within the timeframe of the study. The truck cab assembly workforce was an inception cohort that had been followed from 1994 along with age-matched controls. The Finnish forest workers had cumulative health data on a cohort (n=52) that had been studied from 1976. For a subset of these subjects, there was detailed tactometry testing in 1990, 1995, and 2003. Accordingly, there was historical as well as new prospective data for the industrial cohorts. The Suomossalmi cohort was reassembled only for our study, which precluded follow-up evaluation and because of retirement is almost certainly the last time this historic group will be studied. The study features are: Characterization of the exposure response relationship for hand-arm vibration through a study design, incorporating multiple cohorts, some having existing historical data, Selection of cohorts to include different types of vibration: oscillatory (forest workers) impact (truck cab workers), high frequency (dental hygienists) and mixed (shipyard workers), Inclusion of two inception cohorts: dental hygiene students and Swedish truck cab workers, Methods for multi-site and historical integration. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Cherniack, M AU - Brammer, A J AU - Lundstrom, R AU - Meyer, J D AU - Morse, T F AU - Neely, G AU - Nilsson, T AU - Peterson, D AU - Toppila, E AU - Warren, N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Conferences KW - Finland KW - USA, Connecticut KW - Vibration KW - Forests KW - Trucks KW - Occupational exposure KW - Medical personnel KW - Sweden KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cherniack%2C+M%3BBrammer%2C+A+J%3BLundstrom%2C+R%3BMeyer%2C+J+D%3BMorse%2C+T+F%3BNeely%2C+G%3BNilsson%2C+T%3BPeterson%2C+D%3BToppila%2C+E%3BWarren%2C+N&rft.aulast=Cherniack&rft.aufirst=M&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Prospective+studies+of+vibration+exposed+cohorts%3A+Hand-arm+vibration+international+consortium+%28HAVIC%29&rft.title=Prospective+studies+of+vibration+exposed+cohorts%3A+Hand-arm+vibration+international+consortium+%28HAVIC%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A pilot study of the transmissibility of the rat tail compared to that of the human finger AN - 19387349; 7157597 AB - Continual occupational exposure to vibrating hand tools can damage the neural, vascular and other soft tissues of the fingers. Rat tail models have been developed to investigate the biological responses of the tissues to vibration. However, the biodynamic response of the tail relative to that of the human fingers has not been characterized. The objective of this pilot study was to compare the transmissibilities of rat tails measured via a scanning laser vibrometer to those of human fingers gripping a handle. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Welcome, D AU - Dong, R G AU - Krajnak, K M Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - Vibration KW - Working conditions KW - hand tools KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Welcome%2C+D%3BDong%2C+R+G%3BKrajnak%2C+K+M&rft.aulast=Welcome&rft.aufirst=D&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+pilot+study+of+the+transmissibility+of+the+rat+tail+compared+to+that+of+the+human+finger&rft.title=A+pilot+study+of+the+transmissibility+of+the+rat+tail+compared+to+that+of+the+human+finger&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A multi-body dynamic biomechanical model of a seated human exposed to vertical whole-body vibration AN - 19387328; 7157595 AB - Ethical concerns of in-vivo procedures and poor repeatability of non-invasive techniques have been major limitations in estimating vibration-induced spine loads through experiments. The biodynamic models of seated human body exposed to whole-body vibration (WBV) have evolved for defining the frequency-weightings, enhancement of human responses to WBV, and developing anthropodynamic manikins for seating assessment activities. The widely reported mechanical-equivalent models, solely based on through- or to-the-body biodynamic response functions, do not seem to resemble the biomechanical structure and do not yield information on the dynamic loading and deflections of segments of concern, namely the spine. On the other hand, biomechanical models with representative anatomical structure and anthropometry are being attempted to simulate segmental movements and the coupling effects, using Finite elements (FE) or multi-body dynamics (MBD) formalisms, which could provide important insights into the inter-vertebral forces. While the FE models pose considerable complexities primarily related to characteristics of the bio-material properties, the MBD technique with discrete rigid bodies offers the flexibility to create multi-segment models with relative ease and lower computational cost. In this study, a preliminary multibody dynamic model of a seated human body exposed to WBV along the vertical direction is formulated using MSC/ADAMS software. The model validity is demonstrated by comparing selected responses with the available measured data. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Pranesh, A AU - Rakheja, S AU - Demont, R Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Computer programs KW - spine KW - Vibration KW - biomechanics KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pranesh%2C+A%3BRakheja%2C+S%3BDemont%2C+R&rft.aulast=Pranesh&rft.aufirst=A&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+multi-body+dynamic+biomechanical+model+of+a+seated+human+exposed+to+vertical+whole-body+vibration&rft.title=A+multi-body+dynamic+biomechanical+model+of+a+seated+human+exposed+to+vertical+whole-body+vibration&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Regional cerebral oxygenation and blood volume responses in healthy women during seated whole-body vibration (WBV) AN - 19387300; 7157585 AB - Landstrom et al. (1985) suggested the possibility of cortical activation during exposure to WBV, however, it is not known how cerebral physiology (oxygenation and blood volume) responds in healthy women during different vibration frequencies. This study examined the role of backrest support and handgrip work on cerebral oxygenation and blood volume responses, during exposure to seated WBV. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - Maikala, R V AU - Bhambhani, Y N Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Blood KW - Vibration KW - Physiology KW - Oxygenation KW - Females KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Maikala%2C+R+V%3BBhambhani%2C+Y+N&rft.aulast=Maikala&rft.aufirst=R&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Regional+cerebral+oxygenation+and+blood+volume+responses+in+healthy+women+during+seated+whole-body+vibration+%28WBV%29&rft.title=Regional+cerebral+oxygenation+and+blood+volume+responses+in+healthy+women+during+seated+whole-body+vibration+%28WBV%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Numerical models and hardware dummies for simulating whole-body vibration of human - an overview AN - 19387258; 7157574 AB - The goal of biodynamic models is to simulate the vibration behaviour of the human body. In combination with experimental studies biodynamical models can be a powerful tool for the analysis of the effects of vibration exposure on health and comfort. This paper gives an overview of the state of the art of biodynamic whole-body vibration models of humans, addressing both numerical models and hardware dummies. JF - FIRST AMERICAN CONFERENCE ON HUMAN VIBRATION. AU - WOelfel, H P Y1 - 2006/06// PY - 2006 DA - Jun 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mathematical models KW - Vibration KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=WOelfel%2C+H+P&rft.aulast=WOelfel&rft.aufirst=H&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Numerical+models+and+hardware+dummies+for+simulating+whole-body+vibration+of+human+-+an+overview&rft.title=Numerical+models+and+hardware+dummies+for+simulating+whole-body+vibration+of+human+-+an+overview&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Modifiable Environmental and Behavioral Determinants of Overweight among Children and Adolescents: Report of a Workshop AN - 19366975; 7129867 AB - The number of children at risk for overweight and the number of overweight children are increasing and have become a serious public health concern. Interventions that could be applied at the population level have not been proven effective. The development of effective strategies is thought to be hampered by the lack of understanding of which behavioral and environmental factors need to be modified. On June 14 and 15, 2004, the NIH held a meeting of experts to discuss the issue of modifiable determinants of obesity in children and adolescents. Included were presentations on interventions among children that have been proven effective, dietary and physical activity behavioral determinants, physical, social, and family environmental determinants, and the quality of measures of determinants and correlates of overweight. JF - Obesity Research AU - Johnson-Taylor, Wendy L AU - Everhart, James E AD - Division of Nutrition Research Coordination, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Clinical Trials Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 929 EP - 966 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Issues KW - Adolescence KW - Strategy KW - Family KW - Exercise KW - Children KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Modifiable+Environmental+and+Behavioral+Determinants+of+Overweight+among+Children+and+Adolescents%3A+Report+of+a+Workshop&rft.au=Johnson-Taylor%2C+Wendy+L%3BEverhart%2C+James+E&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2006-06-01&rft.volume=14&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Issues; Adolescence; Strategy; Family; Exercise; Children; Public health ER - TY - JOUR T1 - Genetic Requirements for Growth of Escherichia coli K12 on Methyl- alpha -D-glucopyranoside and the Five alpha -D-Glucosyl-D-fructose Isomers of Sucrose AN - 17258135; 6996402 AB - Strains of Escherichia coli K12, including MG-1655, accumulate methyl- alpha -D-glucopyranoside via the phosphoenolpyruvate-dependent glucose:phosphotransferase system (IICB super(Glc)/IIA super(Glc)). High concentrations of intracellular methyl- alpha -D-glucopyranoside 6-phosphate are toxic, and cell growth is prevented. However, transformation of E. coli MG-1655 with a plasmid (pAP1) encoding the gene aglB from Klebsiella pneumoniae resulted in excellent growth of the transformant MG-1655 (pAP1) on the glucose analog. AglB is an unusual NAD super(+)/Mn super(2+)-dependent phospho- alpha -glucosidase that promotes growth of MG-1655 (pAP1) by catalyzing the in vivo hydrolysis of methyl- alpha -D-glucopyranoside 6-phosphate to yield glucose 6-phosphate and methanol. When transformed with plasmid pAP2 encoding the K. pneumoniae genes aglB and aglA (an alpha -glucoside-specific transporter AglA (IICB super(Agl))), strain MG-1655 (pAP2) metabolized a variety of other alpha -linked glucosides, including maltitol, isomaltose, and the following five isomers of sucrose: trehalulose alpha (1 arrow right 1), turanose alpha (1 arrow right 3), maltulose alpha (1 arrow right 4), leucrose alpha (1 arrow right 5), and palatinose alpha (1 arrow right 6). Remarkably, MG-1655 (pAP2) failed to metabolize sucrose alpha (1 arrow right 2). The E. coli K12 strain ZSC112L (ptsG::cat manXYZ nagE glk lac) can neither grow on glucose nor transport methyl- alpha -D-glucopyranoside. However, when transformed with pTSGH11 (encoding ptsG) or pAP2, this organism provided membranes that contained either the PtsG or AglA transporters, respectively. In vitro complementation of transporter-specific membranes with purified general phosphotransferase components showed that although PtsG and AglA recognized glucose and methyl- alpha -D-glucopyranoside, only AglA accepted other alpha -D-glucosides as substrates. Complementation experiments also revealed that IIA super(Glc) was required for functional activity of both PtsG and AglA transporters. We conclude that AglA, AglB, and IIA super(Glc) are necessary and sufficient for growth of E. coli K12 on methyl- alpha -D-glucoside and related alpha -D-glucopyranosides. JF - Journal of Biological Chemistry AU - Pikis, Andreas AU - Hess, Sonja AU - Arnold, Ingrid AU - Erni, Bernhard AU - Thompson, John AD - Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, NIDCR, and the Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 and the Departement fuer Chemie und Biochemie, Universitaet Bern, CH-3012 Bern, Switzerland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17900 EP - 17908 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 26 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Transformation KW - Methanol KW - phosphotransferase KW - Plasmids KW - glucosides KW - Hydrolysis KW - Isomers KW - Growth KW - Complementation KW - Sucrose KW - Glucose transport KW - Escherichia coli KW - Klebsiella pneumoniae KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17258135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Genetic+Requirements+for+Growth+of+Escherichia+coli+K12+on+Methyl-+alpha+-D-glucopyranoside+and+the+Five+alpha+-D-Glucosyl-D-fructose+Isomers+of+Sucrose&rft.au=Pikis%2C+Andreas%3BHess%2C+Sonja%3BArnold%2C+Ingrid%3BErni%2C+Bernhard%3BThompson%2C+John&rft.aulast=Pikis&rft.aufirst=Andreas&rft.date=2006-06-01&rft.volume=281&rft.issue=26&rft.spage=17900&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Growth; Complementation; Sucrose; Methanol; Glucose transport; phosphotransferase; glucosides; Plasmids; Hydrolysis; Isomers; Escherichia coli; Klebsiella pneumoniae ER - TY - JOUR T1 - Immunologic Consequences of Francisella tularensis Live Vaccine Strain Infection: Role of the Innate Immune Response in Infection and Immunity AN - 17240406; 6948147 AB - Francisella tularensis (Ft), a Gram-negative intracellular bacterium, is the etiologic agent of tularemia. Although attenuated for humans, i.p. infection of mice with 10 super(6) organisms. To examine the immunological consequences of Ft LVS infection on the innate immune response, the inflammatory responses of mice infected i.p. or intradermally were compared. Mice infected i.p. displayed greater bacterial burden and increased expression of proinflammatory genes, particularly in the liver. In contrast to most LPS, highly purified Ft LVS LPS (10 mu g/ml) was found to be only minimally stimulatory in primary murine macrophages and in HEK293T cells transiently transfected with TLR4/MD-2/CD14, whereas live Ft LVS bacteria were highly stimulatory for macrophages and TLR2-expressing HEK293T cells. Despite the poor stimulatory activity of Ft LVS LPS in vitro, administration of 100 ng of Ft LVS LPS 2 days before Ft LVS challenge severely limited both bacterial burden and cytokine mRNA and protein expression in the absence of detectable Ab at the time of bacterial challenge, yet these mice developed a robust IgM Ab response within 2 days of infection and survived. These data suggest that prior administration of Ft LVS LPS protects the host by diminishing bacterial burden and blunting an otherwise overwhelming inflammatory response, while priming the adaptive immune response for development of a strong Ab response. JF - Journal of Immunology AU - Cole, Leah E AU - Elkins, Karen L AU - Michalek, Suzanne M AU - Qureshi, Nilofer AU - Eaton, Linda J AU - Rallabhandi, Prasad AU - Cuesta, Natalia AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research/Food and Drug Administration, Bethesda, MD 20852. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294. Department of Basic Medical Science and/or Surgery, Shock/Trauma Research Center, University of Missouri-Kansas City, School of Medicine, Kansas City, MO 64108. List Biological Laboratories, Campbell, CA 95008 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 6888 EP - 6899 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 11 SN - 0022-1767, 0022-1767 KW - innate immunity KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Francisella tularensis KW - Antibody response KW - Infection KW - CD14 antigen KW - mRNA KW - Inflammation KW - Gene expression KW - Tularemia KW - Liver KW - Cytokines KW - Lipopolysaccharides KW - Vaccines KW - Immune response KW - TLR4 protein KW - Immunoglobulin M KW - Toll-like receptors KW - F 06100:Vaccines - active immunity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17240406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Immunologic+Consequences+of+Francisella+tularensis+Live+Vaccine+Strain+Infection%3A+Role+of+the+Innate+Immune+Response+in+Infection+and+Immunity&rft.au=Cole%2C+Leah+E%3BElkins%2C+Karen+L%3BMichalek%2C+Suzanne+M%3BQureshi%2C+Nilofer%3BEaton%2C+Linda+J%3BRallabhandi%2C+Prasad%3BCuesta%2C+Natalia%3BVogel%2C+Stefanie+N&rft.aulast=Cole&rft.aufirst=Leah&rft.date=2006-06-01&rft.volume=176&rft.issue=11&rft.spage=6888&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Antibody response; CD14 antigen; Infection; Inflammation; mRNA; Gene expression; Tularemia; Liver; Lipopolysaccharides; Cytokines; Immune response; Vaccines; TLR4 protein; Toll-like receptors; Immunoglobulin M; Francisella tularensis ER - TY - JOUR T1 - Determination of Airborne Isocyanates Generated During the Thermal Degradation of Car Paint in Body Repair Shops AN - 17232983; 6945016 AB - Polyurethanes are widely used in car paint formulations. During thermal degradation, such polymeric systems can generate powerful asthmatic sensitizing agents named isocyanates. In body repair shops, the thermal degradation of car paint can occur during abrasive processes that generate enough heat to involve release of isocyanates in air. An environmental monitoring study was performed in two body repair training schools and in a body repair shop to evaluate the workers' exposure to isocyanates during cutting, grinding and orbital sanding operations. For sampling, cassettes containing two 1-(2-methoxyphenyl)piperazine (MOPIP)-coated glass fiber filters (MFs) ( similar to 5 mg of MOPIP per filter) and bubblers containing 15 ml of MOPIP solution in toluene (1.0 mg ml super(-1)) backed at the outlet with cassettes containing two MFs were used. Tandem mass spectrometry was used to analyze the MOPIP derivatives of isocyanic acid (HNCO), all the linear aliphatic isocyanates ranging from methyl isocyanate (Me-i) to hexyl isocyanate, all the alkenyl isocyanates ranging from propylene isocyanate to hexylene isocyanate, 1,6-hexamethylene diisocyanate (HDI), trans- and cis-isophorone diisocyanate (IPDI), 2,4- and 2,6-toluene diisocyanate (TDI), 2,4'-; 2,2'- and 4,4'-methylenediphenyl diisocyanate (MDI), phenyl isocyanate (Ph-i) and p-toluene isocyanate (p-Tol-i). The instrumental detection limits (LOD) were in the 0.13-0.75 mu g of NCO per m super(3) range for 15 l air samples converted into 3 ml liquid samples. The isocyanate concentrations detected in the workers' breathing zone were in the 1.07-9.80 mu g of NCO per m super(3) range for cutting, 0.63-3.62 mu g of NCO per m super(3) range for grinding and 0-1.29 mu g of NCO per m super(3) range for sanding. However, a rapid decrease of the isocyanate concentration was observed while moving away from the emission source. Among the isocyanates detected the most abundant were the monomers (MDI, HDI, TDI and IPDI) and Me-i. JF - Annals of Occupational Hygiene AU - Boutin, Michel AU - Dufresne, Andre AU - Ostiguy, Claude AU - Lesage, Jacques AD - McGill University, 3450 University Street, FDA Building, Room 31, Montreal, Quebec, Canada H3A 2A7 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 385 EP - 393 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 50 IS - 4 SN - 0003-4878, 0003-4878 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Filters KW - Toluene KW - Automotive industry KW - Air sampling KW - Isocyanates KW - Occupational exposure KW - Industrial emissions KW - Paints KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Determination+of+Airborne+Isocyanates+Generated+During+the+Thermal+Degradation+of+Car+Paint+in+Body+Repair+Shops&rft.au=Boutin%2C+Michel%3BDufresne%2C+Andre%3BOstiguy%2C+Claude%3BLesage%2C+Jacques&rft.aulast=Boutin&rft.aufirst=Michel&rft.date=2006-06-01&rft.volume=50&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Filters; Toluene; Automotive industry; Air sampling; Isocyanates; Industrial emissions; Occupational exposure; Paints ER - TY - JOUR T1 - Completeness of cause of injury coding in healthcare administrative databases in the United States, 2001 AN - 17232833; 6947035 AB - OBJECTIVES: To determine the completeness of external cause of injury coding (E-coding) within healthcare administrative databases in the United States and to identify factors that contribute to variations in E-code reporting across states. DESIGN: Cross sectional analysis of the 2001 Healthcare Cost and Utilization Project (HCUP), including 33 State Inpatient Databases (SID), a Nationwide Inpatient Sample (NIS), and nine State Emergency Department Databases (SEDD). To assess state reporting practices, structured telephone interviews were conducted with the data organizations that participate in HCUP. RESULTS: The percent of injury records with an injury E-code was 86% in HCUP's nationally representative database, the NIS. For the 33 states represented in the SID, completeness averaged 87%, with more than half of the states reporting E-codes on at least 90% of injuries. In the nine states also represented in the SEDD, completeness averaged 93%. Twenty two states had mandates for E-code reporting, but only eight had provisions for enforcing the mandates. These eight states had the highest rates of E-code completeness. CONCLUSIONS: E-code reporting in administrative databases is relatively complete, but there is significant variation in completeness across the states. States with mandates for the collection of E-codes and with a mechanism to enforce those mandates had the highest rates of E-code reporting. Nine statewide ED data systems demonstrate consistently high E-coding completeness. JF - Injury Prevention AU - Coben, J H AU - Steiner, C A AU - Barrett, M AU - Merrill, C T AU - Adamson, D AD - Injury Control Research Center, West Virginia University, Morgantown, WV, USA. Agency for Healthcare Research and Quality, Center for Delivery, Organization, and Markets, Rockville, MD, USA. M.L. Barrett, Inc, San Diego, CA, USA. Medstat, Washington, DC, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 199 EP - 201 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 12 IS - 3 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - USA KW - Data collection KW - Injuries KW - Health care KW - Data bases KW - Emergency medical services KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Completeness+of+cause+of+injury+coding+in+healthcare+administrative+databases+in+the+United+States%2C+2001&rft.au=Coben%2C+J+H%3BSteiner%2C+C+A%3BBarrett%2C+M%3BMerrill%2C+C+T%3BAdamson%2C+D&rft.aulast=Coben&rft.aufirst=J&rft.date=2006-06-01&rft.volume=12&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data collection; Health care; Injuries; Data bases; Emergency medical services; USA ER - TY - JOUR T1 - Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts AN - 17232482; 6950189 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies have been performed in mice or rabbits to determine where in the body these plasmid vaccines would biodistribute and how rapidly they would clear. In the course of these studies, it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis. Even though similar to 10 super(14) molecules are inoculated in the studies in rabbits, by day 8 or 9 ( similar to 1 week postinoculation), already all but on the order of 10 super(4)-10 super(6) molecules per microgram of DNA extracted from tissue have been cleared at the injection site. Over the course of 2 months, the plasmid clears from the site of injection with only a small percentage of animals (generally 10-20%) retaining a small number of copies (generally around 100 copies) in the muscle at the injection site. This pattern of biodistribution (confined to the injection site) and clearance (within 2 months) is consistent regardless of differences in the promoter in the plasmid backbone or differences in the gene insert being expressed by the plasmid vaccine. In addition, integration has not been observed with plasmid vaccine candidates inoculated i.m. by Biojector 2000 or by needle and syringe. These data build on the repeated-dose toxicology studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Duffy, Chris AU - Nason, Martha AU - Andrews, Charla AU - Kong, Wing-Pui AU - Nabel, Gary J AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 610 EP - 619 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Severe acute respiratory syndrome KW - Muscles KW - Ebola virus KW - Adjuvants KW - Plasmids KW - Integration KW - Promoters KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Syringes KW - Cytokines KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - X 24240:Miscellaneous KW - N 14810:Methods KW - V 22004:AIDS: Clinical aspects KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Biodistribution+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar%2C+without+Integration%2C+despite+Differing+Plasmid+Backbones+or+Gene+Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BDuffy%2C+Chris%3BNason%2C+Martha%3BAndrews%2C+Charla%3BKong%2C+Wing-Pui%3BNabel%2C+Gary+J%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Muscles; Adjuvants; Plasmids; Promoters; Integration; DNA vaccines; Infectious diseases; DNA; Cytokines; Syringes; Vaccines; Immunoglobulins; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - Dietary Modulation of p-Nonylphenol-Induced Polycystic Kidneys in Male Sprague-Dawley Rats AN - 17231474; 6950191 AB - We had previously found that p-nonylphenol (NP) at 1000-2000 ppm in a soy- and alfalfa-free diet induced severe polycystic kidney disease (PKD) in both male and female pups exposed from gestation day 7 through postnatal day (PND) 50 and hypothesized that differences in dietary components contributed to the severity of lesions relative to those reported in other studies using similar doses of NP. The present study investigated the dietary modulation of NP-induced PKD using the same exposure regimen with 2000 ppm NP in four different diets: the natural ingredient soy- and alfalfa-free diet that had been used in the earlier study, Purina 5K96; two defined diets AIN-93G, designated AIN-CAS, and a modified AIN-93G with soy protein isolate replacing casein as the protein source (AIN-SPI); and the commonly used natural ingredient diet Purina 5001 (P5001). Serum isoflavone levels were negligible in animals fed the soy-free AIN-CAS and 5K96 diets and were 2- to 18-fold higher in animals fed P5001 than in those fed AIN-SPI. Consumption of P5001 was significantly greater than consumption of the other diets, and those animals fed P5001 were generally significantly heavier than animals receiving the other diets. NP significantly reduced body weight gain in male pups regardless of the diet fed. There was no evidence of NP-induced kidney toxicity in male pups at PND 2, 14, or 21 or in the dams. In PND 50 male pups, serum blood urea nitrogen was significantly elevated by NP in all diet groups. Urine volume and urinary N-acetyl {beta}-glucuronidase were significantly increased by NP in the soy-free 5K96 and AIN-CAS diet groups. Relative kidney weights were increased by NP in all diet groups except P5001, with the greatest increase in AIN-CAS and 5K96 diet groups. Microscopic evaluation of kidneys from the PND 50 males showed that NP induced PKD in all diet groups but with marked variation in the severity depending on the diet. PKD was severe in 100% of the NP-treated animals in the AIN-CAS and 5K96 groups, moderate in 88% of the AIN-SPI diet group, and mild in only 40% of the P5001 diet group. Thus, diet can significantly modulate the development of PKD induced by dietary NP in rats. Soy components, as well as other complex dietary factors, may account for the level of protection afforded by the P5001 diet. JF - Toxicological Sciences AU - Cooper, Steven AU - Latendresse, John R AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Fu, Xin AU - Delclos, KBarry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 631 EP - 642 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Diets KW - Polycystic kidney KW - Urea KW - 4-Nonylphenol KW - Toxicity KW - Casein KW - Soybeans KW - Protein sources KW - Blood KW - Urine KW - Gestation KW - Kidney KW - Isoflavone KW - Body weight gain KW - Nitrogen KW - X 24154:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17231474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Dietary+Modulation+of+p-Nonylphenol-Induced+Polycystic+Kidneys+in+Male+Sprague-Dawley+Rats&rft.au=Cooper%2C+Steven%3BLatendresse%2C+John+R%3BDoerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BFu%2C+Xin%3BDelclos%2C+KBarry&rft.aulast=Cooper&rft.aufirst=Steven&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Polycystic kidney; Urea; Toxicity; 4-Nonylphenol; Casein; Soybeans; Protein sources; Blood; Urine; Gestation; Isoflavone; Kidney; Body weight gain; Nitrogen ER - TY - JOUR T1 - An Evaluation of Conditions That May Affect the Performance of Houseboat Exhaust Stacks in Prevention of Carbon Monoxide Poisonings from Generators AN - 17229739; 6943887 AB - National Institute for Occupational Safety and Health (NIOSH) researchers evaluated two exhaust stack designs for reducing carbon monoxide (CO) exposures from gasoline-powered generator exhaust on houseboats. Tests were conducted (a) after dark, (b) in high-temperature and high-humidity environments, (c) during temperature inversions, (d) under various generator loads, and (e) at different houseboat trim angles. Two different designs of houseboat exhaust stacks were evaluated and compared with the side-exhaust configuration, which is standard on many houseboats. The two designs were flagpole and vertical stack. Both exhaust stacks performed dramatically better than the standard water level, side-exhaust configuration. The highest mean CO concentrations on the upper and lower decks of the houseboat with the vertical exhaust stack were 27 ppm and 17 ppm. The highest mean CO concentrations on the upper and lower decks of the houseboat with the modified flagpole stack were 5 ppm and 2 ppm. These findings are much lower than the 67 ppm and 341 ppm for the highest mean CO concentrations found on the upper and lower decks of houseboats having the usual side-exhausted configuration. The NIOSH evaluation also indicated that high-temperature and high-humidity levels, temperature inversions, generator loading, and houseboat trim angles had little effect on the exhaust stack performance. It also demonstrated the importance of proper design and installation of exhaust stacks to ensure that all exhaust gases are released through the stack. Based on the results of this work, NIOSH investigators continue to recommend that houseboat manufacturers, rental companies, and owners retrofit their gasoline-powered generators with exhaust stacks to reduce the hazard of CO poisoning and death to individuals on or near the houseboat. JF - Journal of Occupational and Environmental Hygiene AU - Hammond AU - Earnest, G S AU - Hall, R M AU - Feng, A AD - NIOSH, Division of Applied Research and Technogy, 4676 Columbia Parkway, MS-R5, Cincinnati, Ohio 45226, USA, ahz0@cdc.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 308 EP - 316 VL - 3 IS - 6 SN - 1545-9624, 1545-9624 KW - house boats KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Carbon monoxide KW - Inhalation KW - Mortality KW - Gasoline KW - Temperature KW - Poisoning KW - prevention KW - Stack emissions KW - H 14000:Toxicology KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17229739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=An+Evaluation+of+Conditions+That+May+Affect+the+Performance+of+Houseboat+Exhaust+Stacks+in+Prevention+of+Carbon+Monoxide+Poisonings+from+Generators&rft.au=Hammond%3BEarnest%2C+G+S%3BHall%2C+R+M%3BFeng%2C+A&rft.aulast=Hammond&rft.aufirst=&rft.date=2006-06-01&rft.volume=3&rft.issue=6&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600691249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Carbon monoxide; Mortality; Gasoline; prevention; Poisoning; Temperature; Stack emissions DO - http://dx.doi.org/10.1080/15459620600691249 ER - TY - JOUR T1 - Pesticides associated with Wheeze among Commercial Pesticide Applicators in the Agricultural Health Study AN - 17227252; 6944919 AB - Pesticides are potential risk factors for respiratory disease among farmers, but farmers are also exposed to other respiratory toxicants. To explore the association of pesticides with wheeze in a population without other farming exposures, the authors analyzed data from 2,255 Iowa commercial pesticide applicators enrolled in the Agricultural Health Study. Controlling for age, smoking status, asthma and atopy history, and body mass index, the authors calculated odds ratios for the relationship between wheeze and 36 individual pesticides participants had used during the year before enrollment (1993-1997). Eight of 16 herbicides were associated with wheeze in single-agent models; however, the risk was almost exclusively associated with the herbicide chlorimuron-ethyl (odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.25, 2.10). Inclusion of chlorimuron-ethyl in models for the other herbicides virtually eliminated the associations. The odds ratios for four organophosphate insecticides (terbufos, fonofos, chlorpyrifos, and phorate) were elevated when these chemicals were modeled individually and remained elevated, though attenuated somewhat, when chlorimuron-ethyl was included. The association for dichlorvos, another organophosphate insecticide, was not attenuated by chlorimuron-ethyl (OR = 2.48, 95% CI: 1.08, 5.66). Dose-response trends were observed for chlorimuron-ethyl, chlorpyrifos, and phorate; the strongest odds ratio was for applying chlorpyrifos on more than 40 days per year (OR = 2.40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl. JF - American Journal of Epidemiology AU - Hoppin, Jane A AU - Umbach, David M AU - London, Stephanie J AU - Lynch, Charles F AU - Alavanja, Michael CR AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1129 EP - 1137 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 163 IS - 12 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Toxicants KW - Organophosphates KW - phorate KW - Respiratory diseases KW - Models KW - Smoking KW - Insecticides KW - Dose-response effects KW - Risk factors KW - Occupational exposure KW - Dichlorvos KW - Data processing KW - Asthma KW - Herbicides KW - organophosphates KW - Agrochemicals KW - Chlorpyrifos KW - Atopy KW - USA, Iowa KW - Pesticides KW - Body mass index KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17227252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Pesticides+associated+with+Wheeze+among+Commercial+Pesticide+Applicators+in+the+Agricultural+Health+Study&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+CR%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-06-01&rft.volume=163&rft.issue=12&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Toxicants; phorate; Asthma; Herbicides; organophosphates; Models; Chlorpyrifos; Smoking; Insecticides; Atopy; Risk factors; Pesticides; Body mass index; Dichlorvos; Organophosphates; Dose-response effects; Respiratory diseases; Agrochemicals; Occupational exposure; USA, Iowa ER - TY - JOUR T1 - Using induced accelerations to understand knee stability during gait of individuals with muscle weakness AN - 17168131; 6836826 AB - The purpose of this case series was to quantify the effectiveness of different compensatory strategies used by individuals with muscle weakness to produce knee extension during the stance phase gait. Subjects were three males with less than anti-gravity strength in the quadriceps femoris and a variable pattern of weakness elsewhere in the lower extremity. They walked independently at a self-selected speed without assistive devices. Gait analysis of the pelvis and bilateral lower extremity segments was performed with a six-camera, two force platform motion capture system. Joint angles and net internal moments were computed from the motion data. Induced acceleration analysis was performed to quantify the relative ability of each lower extremity joint moment and gravity to produce knee angular acceleration. Results showed that a variety of adaptive strategies both within and across limbs can control knee position during gait. One subject generated knee extension almost exclusively via the hip extensor moment. Another relied less on the hip extensor moment (39%) and more on the ankle plantar flexor moment (61%) to create knee extension. The third subject used the ipsilateral hip extensor moment (24%) and the contralateral ankle plantar flexor moment (67%) to assist knee extension. The strategy selected by each subject likely was influenced by both their total pattern of impairments and the effectiveness of the available compensations. This case series demonstrates how an induced acceleration analysis can augment a traditional gait analysis to expand and enhance our understanding of compensatory movement control strategies. JF - Gait & Posture AU - Siegel, Karen Lohmann AU - Kepple, Thomas M AU - Stanhope, Steven J AD - Physical Disabilities Branch, National Institutes of Health, Department of Health and Human Services, Building 10, CRC, Room 1-1469, 10 Center Drive, MSC 1604, Bethesda, MD 20892, USA, karen_siegel@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 435 EP - 440 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 23 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Weakness KW - Gait KW - Quadriceps femoris KW - Compensation KW - Motor control KW - Gravity KW - Strategy KW - Force platforms KW - Ankles KW - Knees KW - Legs KW - Muscles (fatigue) KW - Stability KW - Movement KW - Acceleration KW - Hips KW - Joints KW - Pelvis KW - Speed KW - Strength KW - Analysis KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Using+induced+accelerations+to+understand+knee+stability+during+gait+of+individuals+with+muscle+weakness&rft.au=Siegel%2C+Karen+Lohmann%3BKepple%2C+Thomas+M%3BStanhope%2C+Steven+J&rft.aulast=Siegel&rft.aufirst=Karen&rft.date=2006-06-01&rft.volume=23&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2005.05.007 LA - English DB - Physical Education Index N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gravity; Force platforms; Strategy; Knees; Ankles; Legs; Muscles (fatigue); Stability; Acceleration; Movement; Hips; Joints; Pelvis; Strength; Speed; Analysis; Gait; Motor control DO - http://dx.doi.org/10.1016/j.gaitpost.2005.05.007 ER - TY - RPRT T1 - Your Rights under Section 504 of the Rehabilitation Act. Fact Sheet AN - 1697491294; ED553179 AB - Section 504 of the Rehabilitation Act of 1973 is a national law that protects qualified individuals from discrimination based on their disability. The nondiscrimination requirements of the law apply to employers and organizations that receive financial assistance from any Federal department or agency, including the U.S. Department of Health and Human Services (DHHS). These organizations and employers include many hospitals, nursing homes, mental health centers and human service programs. Section 504 forbids organizations and employers from excluding or denying individuals with disabilities an equal opportunity to receive program benefits and services. It defines the rights of individuals with disabilities to participate in, and have access to, program benefits and services. This Fact Sheet outlines who is protected from discrimination, as well as prohibited discriminatory acts in health care and human services settings. Contact information on how to file a complaint of discrimination, or to obtain information of a civil rights nature, is also provided. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 2 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Rehabilitation Act 1973 (Section 504) KW - ERIC, Resources in Education (RIE) KW - Disability Discrimination KW - Health Services KW - Federal Legislation KW - Civil Rights KW - Eligibility KW - Civil Rights Legislation KW - Related Services (Special Education) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697491294?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - CPAPER T1 - Dietary Antioxidant Supplementation Enhances Aged Skeletal Muscle Adaptability to Repeated Exposures of Stretch-Shortening Contractions T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40130424; 4274300 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Cutlip, Robert G AU - Baker, Brent A AU - Geronilla, Ken B AU - Alway, Stephen E Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Skeletal muscle KW - Muscle contraction KW - Antioxidants KW - Dietary supplements KW - Adaptability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40130424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Dietary+Antioxidant+Supplementation+Enhances+Aged+Skeletal+Muscle+Adaptability+to+Repeated+Exposures+of+Stretch-Shortening+Contractions&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BGeronilla%2C+Ken+B%3BAlway%2C+Stephen+E&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic SSC-Exercise Results in Differential Physiological and Morphological Adaptation in Young and Old Rats T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40101771; 4275787 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Baker, Brent A AU - Geronilla, Kenneth B AU - Kashon, Mike L AU - Miller, Gerald R AU - Alway, Stephen E AU - Cutlip, Robert G Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Rats KW - Physiology KW - Adaptations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Chronic+SSC-Exercise+Results+in+Differential+Physiological+and+Morphological+Adaptation+in+Young+and+Old+Rats&rft.au=Baker%2C+Brent+A%3BGeronilla%2C+Kenneth+B%3BKashon%2C+Mike+L%3BMiller%2C+Gerald+R%3BAlway%2C+Stephen+E%3BCutlip%2C+Robert+G&rft.aulast=Baker&rft.aufirst=Brent&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stereological Analysis of Rat Skeletal Muscle Following Dietary Antioxidant Supplementation and Stretch-Shortening Cycle Exercise T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40088338; 4274301 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Mercer, Robert R AU - Baker, Brent A AU - Geronilla, Kenneth B AU - Alway, Stephen E AU - Cutlip, Robert G Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Skeletal muscle KW - Antioxidants KW - Dietary supplements KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40088338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Stereological+Analysis+of+Rat+Skeletal+Muscle+Following+Dietary+Antioxidant+Supplementation+and+Stretch-Shortening+Cycle+Exercise&rft.au=Mercer%2C+Robert+R%3BBaker%2C+Brent+A%3BGeronilla%2C+Kenneth+B%3BAlway%2C+Stephen+E%3BCutlip%2C+Robert+G&rft.aulast=Mercer&rft.aufirst=Robert&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Measurement of Multisite Oxidation Kinetics Reveals an Active Site Conformational Change in Spo0F as a Result of Protein Oxidation AN - 19398659; 7156838 AB - When most proteins undergo oxidative damage, they yield a variety of products containing oxidative damage at a large number of sites, most of which are modified substoichiometrically. The resulting complex mixture of products is not amenable to high-resolution structural analyses. The previous methods of structural analysis have relied upon either very generalized structural analyses such as circular dichroism or the creation of a battery of mutants to try to isolate single-residue damage effects. We present a methodology using mass spectrometry to measure the kinetics of oxidation at many sites simultaneously. Previous studies have shown that these kinetics are determined by the chemical nature of the damage site and by the accessibility of that site to the radical. By measuring deviations in the rate of oxidation from the expected pseudo-zero-order kinetics, we can detect and characterize local structural changes due to the oxidative damage. We demonstrate the application of this new technique to the Spo0F protein, a regulator of sporulation in Bacillus subtilis. Circular dichroism studies suggest a partial loss of helical structure of Spo0F as a result of oxidative damage. We report that oxidation causes a three-stage conformational change in Spo0F. Furthermore, we find the dramatic structural changes affect only the region surrounding the active site, while the remainder of the structure remains relatively unperturbed. Finally, we are able to determine that the specific oxidation event that triggers the conformational change at the active site of Spo0F occurs at Met81, a partially conserved methionine in the CheY superfamily. JF - Biochemistry (Washington) AU - Sharp, J S AU - Sullivan, D M AU - Cavanagh, J AU - Tomer, K B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 SP - 6260 EP - 6266 VL - 45 IS - 20 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Kinetics KW - C.D. KW - Oxidation KW - Sporulation KW - Mass spectroscopy KW - Methionine KW - Radicals KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19398659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Measurement+of+Multisite+Oxidation+Kinetics+Reveals+an+Active+Site+Conformational+Change+in+Spo0F+as+a+Result+of+Protein+Oxidation&rft.au=Sharp%2C+J+S%3BSullivan%2C+D+M%3BCavanagh%2C+J%3BTomer%2C+K+B&rft.aulast=Sharp&rft.aufirst=J&rft.date=2006-05-23&rft.volume=45&rft.issue=20&rft.spage=6260&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi060470r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - C.D.; Kinetics; Oxidation; Sporulation; Methionine; Mass spectroscopy; Radicals; Bacillus subtilis DO - http://dx.doi.org/10.1021/bi060470r ER - TY - CPAPER T1 - Animal Rule Regulatory Issues T2 - 106th General Meeting of the American Society for Microbiology AN - 40150625; 4152788 JF - 106th General Meeting of the American Society for Microbiology AU - Schrager, Lewis K Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Bioterrorism KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Animal+Rule+Regulatory+Issues&rft.au=Schrager%2C+Lewis+K&rft.aulast=Schrager&rft.aufirst=Lewis&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enterobacter sakazakii in Spray-Dried Infant Formula T2 - 106th General Meeting of the American Society for Microbiology AN - 40150556; 4152763 JF - 106th General Meeting of the American Society for Microbiology AU - Buchanan, Robert L Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Infant formulas KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40150556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Enterobacter+sakazakii+in+Spray-Dried+Infant+Formula&rft.au=Buchanan%2C+Robert+L&rft.aulast=Buchanan&rft.aufirst=Robert&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimal Response Adaptive Biased Coin Designs for Randomization to More than Two Treatment Arms T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40128474; 4270142 DE: JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Gwise, Thomas Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40128474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Optimal+Response+Adaptive+Biased+Coin+Designs+for+Randomization+to+More+than+Two+Treatment+Arms&rft.au=Gwise%2C+Thomas&rft.aulast=Gwise&rft.aufirst=Thomas&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Statistical Design and Analysis Issues with Pharmacogenomic Drug-Diagnostic Co-Development T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40125772; 4270068 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Pennello, Gene Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Statistics KW - Pharmacogenomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40125772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Statistical+Design+and+Analysis+Issues+with+Pharmacogenomic+Drug-Diagnostic+Co-Development&rft.au=Pennello%2C+Gene&rft.aulast=Pennello&rft.aufirst=Gene&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Views from a Clinical Trials Participant: Issues Related to Subjective Patient Reported Outcome Responses Including a Comparison of Two Simulated Treatment Groups in which Extreme Values of Ordinal Responses are Under-Reported T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40123391; 4270161 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Massie, Tammy Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Clinical trials KW - Extreme values UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Views+from+a+Clinical+Trials+Participant%3A+Issues+Related+to+Subjective+Patient+Reported+Outcome+Responses+Including+a+Comparison+of+Two+Simulated+Treatment+Groups+in+which+Extreme+Values+of+Ordinal+Responses+are+Under-Reported&rft.au=Massie%2C+Tammy&rft.aulast=Massie&rft.aufirst=Tammy&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Stress Responses in Survival of Gram-Negative Pathogens in Non-PHFs T2 - 106th General Meeting of the American Society for Microbiology AN - 40076584; 4152764 JF - 106th General Meeting of the American Society for Microbiology AU - Zink, Don L Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Pathogens KW - Stress KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40076584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Role+of+Stress+Responses+in+Survival+of+Gram-Negative+Pathogens+in+Non-PHFs&rft.au=Zink%2C+Don+L&rft.aulast=Zink&rft.aufirst=Don&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What are Non-Potentially Hazardous Foods? T2 - 106th General Meeting of the American Society for Microbiology AN - 39166743; 4152760 JF - 106th General Meeting of the American Society for Microbiology AU - Woody, Jon Mikel Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39166743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=What+are+Non-Potentially+Hazardous+Foods%3F&rft.au=Woody%2C+Jon+Mikel&rft.aulast=Woody&rft.aufirst=Jon&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Fluorescein and Phycoerythrin Conjugates for Quantifying CD20 Expression on Normal and Leukemic Bcells T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40021577; 4219917 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Marti, Gerald AU - Wang, Lili AU - Abbasi, Fatima AU - Gaigalas, Adolfas AU - Vogt, Robert F Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Fluorescein KW - Leukemia KW - Phycoerythrins KW - CD20 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Comparison+of+Fluorescein+and+Phycoerythrin+Conjugates+for+Quantifying+CD20+Expression+on+Normal+and+Leukemic+Bcells&rft.au=Marti%2C+Gerald%3BWang%2C+Lili%3BAbbasi%2C+Fatima%3BGaigalas%2C+Adolfas%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiparameter Flow Cytometric Assays for the Study of Apoptosis T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 39949891; 4219972 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Bortner, Carl AU - Sifre, Maria AU - Cidlowski, John Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Multiparameter+Flow+Cytometric+Assays+for+the+Study+of+Apoptosis&rft.au=Bortner%2C+Carl%3BSifre%2C+Maria%3BCidlowski%2C+John&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Analysis of veterinary drug residues in shrimp: a multi-class method by liquid chromatography-quadrupole ion trap mass spectrometry. AN - 67965942; 16597519 AB - A liquid chromatography-mass spectrometry (LC-MS) method was developed to screen and confirm veterinary drug residues in raw shrimp meat. This method simultaneously monitors 18 drugs of different classes, including oxytetracycline (OTC), sulfonamides, quinolones, cationic dyes, and toltrazuril sulfone (TOLS). The homogenized shrimp meat is extracted with 5% trichloroacetic acid. The extract is further cleaned using polymer-based SPE. A 50 mm phenyl column separates the analytes, prior to analysis with an ion trap mass spectrometer interfaced with an atmospheric pressure chemical ionization source. This method is able to confirm oxytetracycline residues at 200 ng/g, toltrazuril sulfone at 50 ng/g, sulfaquinoxaline at 20 ng/g, and the other 15 drugs at 10 ng/g or lower levels. An estimate of the level of residues can also be made so that only confirmed samples above action levels will be sent for quantitation. The method is validated with both fortified and incurred samples, using multiple shrimp species as well. This multi-class method can provide a means to simultaneously monitor for a wide range of illegal drug residues in shrimp. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Li, Hui AU - Kijak, Philip James AU - Turnipseed, Sherri B AU - Cui, Wei AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD 20708, USA. Y1 - 2006/05/19/ PY - 2006 DA - 2006 May 19 SP - 22 EP - 38 VL - 836 IS - 1-2 SN - 1570-0232, 1570-0232 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Spectrometry, Fluorescence KW - Spectrophotometry, Ultraviolet KW - Quality Control KW - Crustacea -- chemistry KW - Veterinary Drugs -- analysis KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67965942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Analysis+of+veterinary+drug+residues+in+shrimp%3A+a+multi-class+method+by+liquid+chromatography-quadrupole+ion+trap+mass+spectrometry.&rft.au=Li%2C+Hui%3BKijak%2C+Philip+James%3BTurnipseed%2C+Sherri+B%3BCui%2C+Wei&rft.aulast=Li&rft.aufirst=Hui&rft.date=2006-05-19&rft.volume=836&rft.issue=1-2&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. AN - 67982844; 16707588 AB - On March 25, 2005, bortezomib (Velcade for Injection; Millennium Pharmaceuticals, Inc., Cambridge, MA, and Johnson & Johnson Pharmaceutical Research & Development, L.L.C.) received regular approval from the U.S. Food and Drug Administration (U.S. FDA) for the treatment of multiple myeloma (MM) progressing after at least one prior therapy. This approval was based on bortezomib's efficacy and safety which was shown in a single, large, comparative international open-label phase 3 trial that randomized 669 patients with MM previously treated with at least one systemic regimen to receive single-agent bortezomib or high-dose dexamethasone. The FDA analysis of the trial data and bortezomib's regulatory development are summarized here. Following a preplanned interim analysis of time to disease progression (the primary end point), an independent data-monitoring committee advised the sponsor to halt the study and offer bortezomib to all dexamethasone-treated study patients. Time to progression was significantly prolonged in the bortezomib treatment arm (median, 6.2 months) compared with the dexamethasone arm (median, 3.5 months; log-rank test, P < 0.0001; hazard ratio, 0.55; 95% confidence interval, 0.44-0.69). Analysis of overall survival done on the interim database (with 20% of events) showed the superiority of bortezomib for patients (log-rank test, P < 0.05; hazard ratio, 0.57; 95% confidence interval, 0.40-0.81). Using criteria from the European Group for Blood and Marrow Transplantation, the response rate (complete plus partial response) with bortezomib was also superior to dexamethasone (38% versus 18%; P < 0.0001). Adverse events on the bortezomib arm were similar to those previously observed in phase 2 studies; some notable adverse events included asthenia, peripheral neuropathy, thrombocytopenia, and neutropenia. The U.S. FDA had earlier (May 2003) granted bortezomib accelerated approval for the treatment of patients with MM progressing after two prior therapies. The results of the phase 3 trial and the FDA analysis of the data, along with the sponsor's completion of other postmarketing commitments, confirm bortezomib's benefit and support regular approval. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kane, Robert C AU - Farrell, Ann T AU - Sridhara, Rajeshwari AU - Pazdur, Richard AD - Division of Drug Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0004, USA. robert.kane@fda.hhs.gov Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 2955 EP - 2960 VL - 12 IS - 10 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Boronic Acids KW - Pyrazines KW - Bortezomib KW - 69G8BD63PP KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - United States KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Dexamethasone -- therapeutic use KW - Clinical Trials, Phase III as Topic KW - Humans KW - Disease Progression KW - Aged KW - United States Food and Drug Administration KW - Dexamethasone -- adverse effects KW - Middle Aged KW - Female KW - Male KW - Survival Analysis KW - Pyrazines -- therapeutic use KW - Multiple Myeloma -- drug therapy KW - Drug Approval KW - Boronic Acids -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Boronic Acids -- therapeutic use KW - Pyrazines -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67982844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=United+States+Food+and+Drug+Administration+approval+summary%3A+bortezomib+for+the+treatment+of+progressive+multiple+myeloma+after+one+prior+therapy.&rft.au=Kane%2C+Robert+C%3BFarrell%2C+Ann+T%3BSridhara%2C+Rajeshwari%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2006-05-15&rft.volume=12&rft.issue=10&rft.spage=2955&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-26 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus. AN - 67901240; 16504399 AB - Expression of the chemokine (C-C motif) ligand 2 (CCL2), also known as, monocyte chemoattractant protein (MCP)-1, increases in response to disease-, trauma-, or toxicant-induced damage to the central nervous system (CNS). In the periphery, endogenous and exogenous glucocorticoids are known to suppress CCL2 expression associated with inflammatory conditions. However, such actions of glucocorticoids on CCL2 expression in the CNS remain unknown. Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats. An immunosuppressive regimen of CORT did not alter the mRNA expression of CCL2 or its receptors in the hippocampus. ADX, however, markedly increased the expression of CCL2 and CCR2 mRNAs in the hippocampus, while CORT replacement reversed the effects of ADX on CCL2 gene expression. Hippocampal damage resulting from systemic administration of the organometallic neurotoxicant, TMT, was associated with microglial activation, as evidenced by enhanced expression of microglial markers integrin alphaM (CD11b) and F4/80, as well as, microglia-associated factors, CCL2 and IL-1alpha. An immunosuppressive dose of CORT, suppressed TMT-induced expression of CCL2. Given the association of CCL2 with microglial activation, it appears that CORT may play a role in regulating microglial activation. However, CORT treatment did not alter TMT-mediated neuronal damage and astrogliosis. Such observations suggest that injury-related expression of microglia-associated chemokines and cytokines may subserve a role unrelated to neuronal damage. In summary, our data indicate that in the CNS, CCL2 gene expression is under negative regulation by glucocorticoids. JF - Neuroscience letters AU - Little, Alvin R AU - Sriram, Krishnan AU - O'Callaghan, James P AD - Molecular Neurotoxicology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, CDC-NIOSH, TMBB-HELD, MS 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 162 EP - 166 VL - 399 IS - 1-2 SN - 0304-3940, 0304-3940 KW - Antigens, CD11b KW - 0 KW - Ccl2 protein, rat KW - Ccr2 protein, rat KW - Chemokine CCL2 KW - Glucocorticoids KW - Immunosuppressive Agents KW - RNA, Messenger KW - Receptors, CCR2 KW - Receptors, CCR5 KW - Receptors, Chemokine KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Rats, Long-Evans KW - Antigens, CD11b -- biosynthesis KW - Antigens, CD11b -- genetics KW - Astrocytes -- drug effects KW - Neurons -- drug effects KW - Receptors, Chemokine -- genetics KW - Adrenalectomy KW - Receptors, CCR5 -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Neurons -- pathology KW - Receptors, Chemokine -- biosynthesis KW - Rats KW - Gliosis -- pathology KW - Receptors, CCR5 -- genetics KW - Gliosis -- chemically induced KW - Astrocytes -- pathology KW - Male KW - Corticosterone -- metabolism KW - Chemokine CCL2 -- genetics KW - Hippocampus -- metabolism KW - Chemokine CCL2 -- biosynthesis KW - Hippocampus -- pathology KW - Corticosterone -- pharmacology KW - Trimethyltin Compounds -- toxicity KW - Glucocorticoids -- pharmacology KW - Immunosuppressive Agents -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67901240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Corticosterone+regulates+expression+of+CCL2+in+the+intact+and+chemically+injured+hippocampus.&rft.au=Little%2C+Alvin+R%3BSriram%2C+Krishnan%3BO%27Callaghan%2C+James+P&rft.aulast=Little&rft.aufirst=Alvin&rft.date=2006-05-15&rft.volume=399&rft.issue=1-2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Common Ground for the Control of Multidrug-Resistant Salmonella in Ground Beef AN - 19996130; 6858271 AB - A strategy to combat multidrug-resistant (MDR) Salmonella in ground beef is urgently needed. A national multi-disciplinary meeting reviewed the epidemiology of MDR Salmonella infection and contamination in humans, animals, and retail meat. In spite of a recent overall decrease in human MDR Salmonella isolates, certain types, such as Salmonella enterica serotype Newport multidrug-resistant-AmpC strain and Salmonella enterica serotype Typhimurium definitive type (DT) 104, have persisted, and several recent large outbreaks of human infection have occurred. Key agencies that contribute to a safe ground beef supply were represented at the meeting and contributed to the discussion of possible control strategies from the farm to the table. Several of the control strategies suggested are unpopular to some, including restricting the use of antimicrobial agents in food animals, designation of multidrug-resistant Salmonella as an adulterant in ground beef, and improving the mechanisms for product trace-back investigations. Nevertheless, enhanced farm-based animal infection control, judicious veterinary and human antibiotic use, regulatory controls, and consumer practices will lead to important industry, veterinary, and public health outcomes. JF - Clinical Infectious Diseases AU - Talbot, E A AU - Gagnon, E R AU - Greenblatt, J AD - New Hampshire Department of Health and Human Services, Concord, NH, USA Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 1455 EP - 1462 VL - 42 IS - 10 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Farms KW - Serotypes KW - Drug resistance KW - Food KW - Antibiotics KW - Food contamination KW - Infection KW - Antimicrobial agents KW - Public health KW - Meat KW - Epidemiology KW - Beef KW - Salmonella enterica KW - Reviews KW - Consumers KW - A 01019:Sterilization, preservation & packaging KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19996130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Common+Ground+for+the+Control+of+Multidrug-Resistant+Salmonella+in+Ground+Beef&rft.au=Talbot%2C+E+A%3BGagnon%2C+E+R%3BGreenblatt%2C+J&rft.aulast=Talbot&rft.aufirst=E&rft.date=2006-05-15&rft.volume=42&rft.issue=10&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serotypes; Farms; Food; Drug resistance; Antibiotics; Infection; Food contamination; Public health; Antimicrobial agents; Meat; Epidemiology; Beef; Reviews; Consumers; Salmonella enterica ER - TY - CPAPER T1 - Identification of Risk Factors Leading to Injuries Among Package Delivery Drivers T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40109603; 4241498 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Pan, C AU - Pratt, S AU - Hoskin, A AU - Lin, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Injuries KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40109603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Identification+of+Risk+Factors+Leading+to+Injuries+Among+Package+Delivery+Drivers&rft.au=Pan%2C+C%3BPratt%2C+S%3BHoskin%2C+A%3BLin%2C+M&rft.aulast=Pan&rft.aufirst=C&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Computer Database of Skin Sensitizers T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40108807; 4241729 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Fedorowicz, A AU - Michette, T Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Skin KW - Databases KW - Computers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40108807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Development+of+a+Computer+Database+of+Skin+Sensitizers&rft.au=Fedorowicz%2C+A%3BMichette%2C+T&rft.aulast=Fedorowicz&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Surrogate Standards for GC/MS Quantitation of Asphalt Fume Condensate T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40108733; 4241706 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Law, B AU - Stone, S AU - Frazer, D AU - Siegel, P Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Fumes KW - Guanylate cyclase KW - Condensates KW - Asphalt KW - Quantitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40108733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Surrogate+Standards+for+GC%2FMS+Quantitation+of+Asphalt+Fume+Condensate&rft.au=Law%2C+B%3BStone%2C+S%3BFrazer%2C+D%3BSiegel%2C+P&rft.aulast=Law&rft.aufirst=B&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Occupational Hygiene Capacity in Developing Nations, NIOSH Activities 1997-2005 T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107683; 4241531 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Sussell, A AU - Fingerhut, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Hygiene KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Building+Occupational+Hygiene+Capacity+in+Developing+Nations%2C+NIOSH+Activities+1997-2005&rft.au=Sussell%2C+A%3BFingerhut%2C+M&rft.aulast=Sussell&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Body Mass Index with Facial Dimensions for Defining Respirator Fit Panels T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107386; 4241500 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Roberge, R AU - Zhuang, Z AU - Stein, L Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Body mass index KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Association+of+Body+Mass+Index+with+Facial+Dimensions+for+Defining+Respirator+Fit+Panels&rft.au=Roberge%2C+R%3BZhuang%2C+Z%3BStein%2C+L&rft.aulast=Roberge&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Airborne Hexamethylene Diisocyanate and Particulate Exposures During Fire/Rescue Vehicle Ladder Finishing Operations T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40107041; 4241718 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Methner, M AU - Achutan, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Particulates KW - Fires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40107041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Airborne+Hexamethylene+Diisocyanate+and+Particulate+Exposures+During+Fire%2FRescue+Vehicle+Ladder+Finishing+Operations&rft.au=Methner%2C+M%3BAchutan%2C+C&rft.aulast=Methner&rft.aufirst=M&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silo Explosion at a Lumber Company - A Case Study on Extinguishing a Fire in an Oxygen-Limiting Silo T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40106941; 4241684 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Berardinelli, S AU - Guglielmo, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Explosions KW - Fires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40106941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Silo+Explosion+at+a+Lumber+Company+-+A+Case+Study+on+Extinguishing+a+Fire+in+an+Oxygen-Limiting+Silo&rft.au=Berardinelli%2C+S%3BGuglielmo%2C+C&rft.aulast=Berardinelli&rft.aufirst=S&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fungal Genera and Species Observed on Wide Body Commercial Passenger Aircraft and Airport Terminals T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40106009; 4241575 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Taylor, L AU - Wallingford, K AU - Hein, M AU - Burge, H AU - Herrick, R Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Aircraft KW - Airports UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40106009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Fungal+Genera+and+Species+Observed+on+Wide+Body+Commercial+Passenger+Aircraft+and+Airport+Terminals&rft.au=Taylor%2C+L%3BWallingford%2C+K%3BHein%2C+M%3BBurge%2C+H%3BHerrick%2C+R&rft.aulast=Taylor&rft.aufirst=L&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Systems Approach to the Optimal Design of Safe Rooms for Shelter-in-Place Scenarios T2 - 8th International Conference on Ventilation (VENT 2006) AN - 40104165; 4241397 DE: JF - 8th International Conference on Ventilation (VENT 2006) AU - Bennett, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40104165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.atitle=A+Systems+Approach+to+the+Optimal+Design+of+Safe+Rooms+for+Shelter-in-Place+Scenarios&rft.au=Bennett%2C+J&rft.aulast=Bennett&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/aihce06/vent-sessions-ataglance.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Major Human Metabolite of Acetochlor in Exposed Herbicide Applicators by High Performance Liquid Chromatography-Tandem Mass Spectrometry T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40089525; 4241653 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Hines, C AU - Striley, C AU - Barr, D AU - Olsson, A AU - Bravo, R AU - Norrgran, J AU - Needham, L AU - Deddens, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Mass spectroscopy KW - Metabolites KW - Herbicides KW - Pesticides KW - Acetochlor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40089525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Identification+of+a+Major+Human+Metabolite+of+Acetochlor+in+Exposed+Herbicide+Applicators+by+High+Performance+Liquid+Chromatography-Tandem+Mass+Spectrometry&rft.au=Hines%2C+C%3BStriley%2C+C%3BBarr%2C+D%3BOlsson%2C+A%3BBravo%2C+R%3BNorrgran%2C+J%3BNeedham%2C+L%3BDeddens%2C+J&rft.aulast=Hines&rft.aufirst=C&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Guidance for the Evaluation of Direct-Reading Gas and Vapor Monitors T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069745; 4241617 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Kennedy, E AU - Woebkenberg, M AU - Schlecht, P AU - Bartley, D AU - Shulman, S AU - Feng, H AU - Song, R AU - Cowherd, C AU - Grelinger, M AU - Bauer, K Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Vapors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Guidance+for+the+Evaluation+of+Direct-Reading+Gas+and+Vapor+Monitors&rft.au=Kennedy%2C+E%3BWoebkenberg%2C+M%3BSchlecht%2C+P%3BBartley%2C+D%3BShulman%2C+S%3BFeng%2C+H%3BSong%2C+R%3BCowherd%2C+C%3BGrelinger%2C+M%3BBauer%2C+K&rft.aulast=Kennedy&rft.aufirst=E&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Respirable Dust Exposures of Workers Using an Improved Clothes Cleaning Process T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069649; 4241602 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Cecala, A AU - Pollock, D AU - O'Brien, A AU - Howell, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Cleaning process KW - Dust KW - Occupational exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Reducing+Respirable+Dust+Exposures+of+Workers+Using+an+Improved+Clothes+Cleaning+Process&rft.au=Cecala%2C+A%3BPollock%2C+D%3BO%27Brien%2C+A%3BHowell%2C+J&rft.aulast=Cecala&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suspension Tolerance in Men and Women Wearing Safety Harnesses T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40069306; 4241601 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Turner, N AU - Weaver, D AU - Whisler, R AU - Zwiener, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Suspension UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Suspension+Tolerance+in+Men+and+Women+Wearing+Safety+Harnesses&rft.au=Turner%2C+N%3BWeaver%2C+D%3BWhisler%2C+R%3BZwiener%2C+J&rft.aulast=Turner&rft.aufirst=N&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respirator Use and Practices by National Demolition Association Member Companies T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40068433; 4241734 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Doney, B AU - Greskevitch, M AU - Groce, D Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40068433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Respirator+Use+and+Practices+by+National+Demolition+Association+Member+Companies&rft.au=Doney%2C+B%3BGreskevitch%2C+M%3BGroce%2C+D&rft.aulast=Doney&rft.aufirst=B&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissolution of Finely Divided Single-Constituent and Multi-Constituent Beryllium Aerosol Materials Associated with Beryllium Sensitization and Chronic Beryllium Disease T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40068220; 4241682 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Stefaniak, A AU - Hoover, M AU - Day, G AU - Breysse, P AU - Scripsick, R Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Beryllium KW - Aerosols KW - Berylliosis KW - Dissolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40068220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Dissolution+of+Finely+Divided+Single-Constituent+and+Multi-Constituent+Beryllium+Aerosol+Materials+Associated+with+Beryllium+Sensitization+and+Chronic+Beryllium+Disease&rft.au=Stefaniak%2C+A%3BHoover%2C+M%3BDay%2C+G%3BBreysse%2C+P%3BScripsick%2C+R&rft.aulast=Stefaniak&rft.aufirst=A&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Questionnaire Modes and Distribution Methods in a Large Medical Center -- Results of a Pilot Test T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40060355; 4241719 DE: JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Boiano, J AU - Piacitelli, G AU - Sieber, K AU - Catalano, J AU - Heyer, N AU - Payne, B Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Questionnaire+Modes+and+Distribution+Methods+in+a+Large+Medical+Center+--+Results+of+a+Pilot+Test&rft.au=Boiano%2C+J%3BPiacitelli%2C+G%3BSieber%2C+K%3BCatalano%2C+J%3BHeyer%2C+N%3BPayne%2C+B&rft.aulast=Boiano&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineering Controls for Cutting Concrete Tiles T2 - 8th International Conference on Ventilation (VENT 2006) AN - 40059488; 4241429 JF - 8th International Conference on Ventilation (VENT 2006) AU - Sheehy, J AU - Echt, A AU - Garcia, A Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Concrete UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40059488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.atitle=Engineering+Controls+for+Cutting+Concrete+Tiles&rft.au=Sheehy%2C+J%3BEcht%2C+A%3BGarcia%2C+A&rft.aulast=Sheehy&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Ventilation+%28VENT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/aihce06/vent-sessions-ataglance.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of X-Ray Fluorescence and Wet Chemical Analysis of Air Filter Samples from a Lead/Zinc/Silver Ore Concentrator Mill T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40021264; 4241637 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Harper, M AU - Pacolay, B AU - Hintz, P AU - Andrew, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Pollutant removal KW - Zinc KW - Chemical analysis KW - Silver KW - Fluorescence KW - Air purification KW - Lead KW - Filters KW - Heavy metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+Comparison+of+X-Ray+Fluorescence+and+Wet+Chemical+Analysis+of+Air+Filter+Samples+from+a+Lead%2FZinc%2FSilver+Ore+Concentrator+Mill&rft.au=Harper%2C+M%3BPacolay%2C+B%3BHintz%2C+P%3BAndrew%2C+M&rft.aulast=Harper&rft.aufirst=M&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of Fecal Contamination Within a Machine at a Manufacturing Site T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40021090; 4241643 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Ewers, L AU - Tapp, L AU - Achutan, C Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evidence+of+Fecal+Contamination+Within+a+Machine+at+a+Manufacturing+Site&rft.au=Ewers%2C+L%3BTapp%2C+L%3BAchutan%2C+C&rft.aulast=Ewers&rft.aufirst=L&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Respirator Fit Test Panel Based on Principal Component Analysis T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40020874; 4241499 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Zhuang, Z AU - Shaffer, R AU - Bradtmiller, B Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Respirators KW - Protective equipment KW - Principal components analysis KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+New+Respirator+Fit+Test+Panel+Based+on+Principal+Component+Analysis&rft.au=Zhuang%2C+Z%3BShaffer%2C+R%3BBradtmiller%2C+B&rft.aulast=Zhuang&rft.aufirst=Z&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIOSH Health Hazard Evaluation of a Cultured Marble Manufacturing Facility T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019991; 4241721 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - McCleery, R AU - Tubbs, R AU - Warren, A Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Marble KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=NIOSH+Health+Hazard+Evaluation+of+a+Cultured+Marble+Manufacturing+Facility&rft.au=McCleery%2C+R%3BTubbs%2C+R%3BWarren%2C+A&rft.aulast=McCleery&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Proposed Ventilation Equations for Exothermic Process Control T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019942; 4241693 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - McKernan, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Ventilation KW - Mathematical models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Evaluation+of+Proposed+Ventilation+Equations+for+Exothermic+Process+Control&rft.au=McKernan%2C+J&rft.aulast=McKernan&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Storage Conditions on Recovering Culturable Fungi from Dust Samples T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40019854; 4241701 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Park, J AU - Pearce, T AU - Cox-Ganser, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Dust KW - Fungi KW - Airborne microorganisms KW - Storage KW - Storage conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Effects+of+Storage+Conditions+on+Recovering+Culturable+Fungi+from+Dust+Samples&rft.au=Park%2C+J%3BPearce%2C+T%3BCox-Ganser%2C+J&rft.aulast=Park&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laboratory Evaluation to Reduce Respirable Crystalline Silica Dust when Cutting Cement Roofing Tiles Using a Masonry Saw T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40004021; 4241603 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Valladares, R AU - Sieber, W AU - Kratzer, J Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Dust KW - Silica KW - Cement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Laboratory+Evaluation+to+Reduce+Respirable+Crystalline+Silica+Dust+when+Cutting+Cement+Roofing+Tiles+Using+a+Masonry+Saw&rft.au=Valladares%2C+R%3BSieber%2C+W%3BKratzer%2C+J&rft.aulast=Valladares&rft.aufirst=R&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of X-Ray Fluorescence and Wet Chemical Analysis of Air Filter Samples From a Lead-Acid Battery Recycling Plant (Secondary Lead Smelter) T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 39965373; 4241539 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Hintz, P AU - Harper, M AU - Pacolay, B AU - Andrew, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Pollutant removal KW - Chemical analysis KW - Waste management KW - Recycling KW - Fluorescence KW - Smelters KW - Batteries KW - Air purification KW - Mining KW - Lead KW - Filters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39965373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+Comparison+of+X-Ray+Fluorescence+and+Wet+Chemical+Analysis+of+Air+Filter+Samples+From+a+Lead-Acid+Battery+Recycling+Plant+%28Secondary+Lead+Smelter%29&rft.au=Hintz%2C+P%3BHarper%2C+M%3BPacolay%2C+B%3BAndrew%2C+M&rft.aulast=Hintz&rft.aufirst=P&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lower Extremity Balance Demand for Construction Workers on Stilts T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 39965137; 4241489 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Chiou, S AU - Pan, C AU - Zwiener, J AU - Cantis, D AU - Ronaghi, M Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Construction industry KW - Extremities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39965137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=Lower+Extremity+Balance+Demand+for+Construction+Workers+on+Stilts&rft.au=Chiou%2C+S%3BPan%2C+C%3BZwiener%2C+J%3BCantis%2C+D%3BRonaghi%2C+M&rft.aulast=Chiou&rft.aufirst=S&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-Strand DNA Breaks Associated with Class Switch Recombination T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39245752; 4229159 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Arudchandran, Arulvathani AU - Bernstein, Ralph AU - Max, Edward Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - DNA KW - Recombination KW - Class switching KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39245752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Single-Strand+DNA+Breaks+Associated+with+Class+Switch+Recombination&rft.au=Arudchandran%2C+Arulvathani%3BBernstein%2C+Ralph%3BMax%2C+Edward&rft.aulast=Arudchandran&rft.aufirst=Arulvathani&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Statins, Inhibitors of HmG CoA Reductase, Directly Affect Morphology and Migration of Activated CD4 T Lymphocytes. T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39191531; 4228504 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Arora, Kamalpreet AU - Chen, Trina AU - Hill, Chris AU - Kozlowski, Steven AU - Reischl, Ilona Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes KW - Morphology KW - Hydroxymethylglutaryl-CoA reductase KW - Lymphocytes T KW - CD4 antigen KW - Cell migration KW - Statins KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39191531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Statins%2C+Inhibitors+of+HmG+CoA+Reductase%2C+Directly+Affect+Morphology+and+Migration+of+Activated+CD4+T+Lymphocytes.&rft.au=Arora%2C+Kamalpreet%3BChen%2C+Trina%3BHill%2C+Chris%3BKozlowski%2C+Steven%3BReischl%2C+Ilona&rft.aulast=Arora&rft.aufirst=Kamalpreet&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Double-Stranded RNA-Induced Type I IFN Induces Immunoproteasomes during Viral Infection T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39191427; 4229470 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Feinstone, Stephen AU - Kloetzel, Peter-M AU - Rehermann, Barbara AU - Rice, Charles AU - Seifert, Ulrike AU - Cheol, EuiShin Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Infection KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39191427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Double-Stranded+RNA-Induced+Type+I+IFN+Induces+Immunoproteasomes+during+Viral+Infection&rft.au=Feinstone%2C+Stephen%3BKloetzel%2C+Peter-M%3BRehermann%2C+Barbara%3BRice%2C+Charles%3BSeifert%2C+Ulrike%3BCheol%2C+EuiShin&rft.aulast=Feinstone&rft.aufirst=Stephen&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biota-Bound Cyanobacterial Hepatotoxins in Lakes Surrounding the City of Riga, Latvia, and in Southern Gulf of Riga (the Baltic Sea) T2 - 16th Europe Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC 2006) AN - 39206263; 4217792 JF - 16th Europe Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC 2006) AU - Balode, M AU - Kankaanpaa, H AU - Purina, A AU - Olin, M AU - Sjovall, O AU - Bumane, D AU - Barda, I AU - Meriluoto, J Y1 - 2006/05/07/ PY - 2006 DA - 2006 May 07 KW - Baltic Sea, Riga Gulf KW - Latvia KW - Urban areas KW - Lakes KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39206263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Europe+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2006%29&rft.atitle=Biota-Bound+Cyanobacterial+Hepatotoxins+in+Lakes+Surrounding+the+City+of+Riga%2C+Latvia%2C+and+in+Southern+Gulf+of+Riga+%28the+Baltic+Sea%29&rft.au=Balode%2C+M%3BKankaanpaa%2C+H%3BPurina%2C+A%3BOlin%2C+M%3BSjovall%2C+O%3BBumane%2C+D%3BBarda%2C+I%3BMeriluoto%2C+J&rft.aulast=Balode&rft.aufirst=M&rft.date=2006-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Europe+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/welcome.do?type=public&congress =44_AM06 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real Time Measurement of Heating Near Metallic Implants Throughout a Phantom using Phase-Shift MR Thermometry T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40021137; 4243391 DE: JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bassen, Howard AU - Kam, Anthony AU - Kainz, Wolfgang AU - Mendoza, Gonzalo AU - Wang, Honghui Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40021137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Real+Time+Measurement+of+Heating+Near+Metallic+Implants+Throughout+a+Phantom+using+Phase-Shift+MR+Thermometry&rft.au=Bassen%2C+Howard%3BKam%2C+Anthony%3BKainz%2C+Wolfgang%3BMendoza%2C+Gonzalo%3BWang%2C+Honghui&rft.aulast=Bassen&rft.aufirst=Howard&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficient, Robust, Nonlinear, and Guaranteed Positive Definite Diffusion Tensor Estimation T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39992677; 4242560 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Cox, Robert W AU - Glen, Daniel Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Efficient%2C+Robust%2C+Nonlinear%2C+and+Guaranteed+Positive+Definite+Diffusion+Tensor+Estimation&rft.au=Cox%2C+Robert+W%3BGlen%2C+Daniel&rft.aulast=Cox&rft.aufirst=Robert&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Determination of 17alpha-methyltestosterone in muscle tissues of tilapia, rainbow trout, and salmon using liquid chromatography-tandem mass spectrometry. AN - 67901422; 16637671 AB - An analytical method was developed to quantitate and confirm the presence of 17alpha-methyltestosterone in the muscles of tilapia, rainbow trout, and salmon. The method employed two liquid-liquid partitioning steps and two solid-phase extraction columns for sample cleanup. The final extracts were analyzed on an isocratic reverse-phase liquid chromatography-tandem mass spectrometry system with atmospheric-pressure chemical ionization in the positive ion mode. The method was validated at levels from 0.40 to 1.6 ng/g, with MT-d3 used as an internal standard. The accuracy was between 100% and 110%, and coefficients of variation of <10% were obtained for all three fish species. Muscle tissues from dosed fish were also assayed to demonstrate the effectiveness of the method for recovering the parent drug. JF - Journal of agricultural and food chemistry AU - Chu, Pak-Sin AU - Lopez, Mayda AU - Serfling, Stan AU - Gieseker, Charlie AU - Reimschuessel, Renate AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA. Pak.Chu@FDA.GOV Y1 - 2006/05/03/ PY - 2006 DA - 2006 May 03 SP - 3193 EP - 3198 VL - 54 IS - 9 SN - 0021-8561, 0021-8561 KW - Methyltestosterone KW - V9EFU16ZIF KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Food Contamination -- analysis KW - Salmon KW - Muscles -- chemistry KW - Chromatography, Liquid -- methods KW - Mass Spectrometry -- methods KW - Oncorhynchus mykiss KW - Methyltestosterone -- analysis KW - Tilapia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67901422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+17alpha-methyltestosterone+in+muscle+tissues+of+tilapia%2C+rainbow+trout%2C+and+salmon+using+liquid+chromatography-tandem+mass+spectrometry.&rft.au=Chu%2C+Pak-Sin%3BLopez%2C+Mayda%3BSerfling%2C+Stan%3BGieseker%2C+Charlie%3BReimschuessel%2C+Renate&rft.aulast=Chu&rft.aufirst=Pak-Sin&rft.date=2006-05-03&rft.volume=54&rft.issue=9&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-20 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Preaching or Teaching: The Power of Stories to Change Worker Behavior T2 - 8th World Conference on Injury Prevention and Safety Promotion AN - 40064677; 4250715 JF - 8th World Conference on Injury Prevention and Safety Promotion AU - Cullen, E Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 KW - Education KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40064677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.atitle=Preaching+or+Teaching%3A+The+Power+of+Stories+to+Change+Worker+Behavior&rft.au=Cullen%2C+E&rft.aulast=Cullen&rft.aufirst=E&rft.date=2006-05-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.issn=&rft_id=info:doi/ L2 - http://www.safety2006.info/programme.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Tissue deformation induced by radiation force from Gaussian transducers. AN - 85387173; pmid-16708969 AB - Imaging techniques based upon the tissue mechanical response to an acoustic radiation force are being actively researched. In this paper a model for predicting steady-state tissue displacement induced by a radiation force arising from the absorption of Gaussian ultrasound beams is presented. A simple analytic expression is derived that agrees closely with the numerical quadrature of the displacement convolution integrals. The analytic result reveals the dependence of the steady-state axial displacement upon the operational parameters, e.g., an inverse proportional relationship to the tissue shear modulus. The derivation requires that the transducer radius be small compared to the focal length, but accurate results were obtained for transducer radii comparable to the focal length. Favorable comparisons with displacement predictions for non-Gaussian transducers indicate that the theory is also useful for a broader range of transducer intensity profiles. JF - The Journal of the Acoustical Society of America AU - Myers, Matthew R AD - Center for Devices and Radiological Health, HFZ-170, U. S. Food and Drug Administration, Rockville, Maryland 20852, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3147 EP - 3152 VL - 119 IS - 5 Pt 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Acoustics: instrumentation KW - *Breast: physiology KW - Elasticity KW - Humans KW - *Liver: physiology KW - *Models, Biological KW - Normal Distribution KW - Stress, Mechanical KW - Transducers KW - *Vitreous Body: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Tissue+deformation+induced+by+radiation+force+from+Gaussian+transducers.&rft.au=Myers%2C+Matthew+R&rft.aulast=Myers&rft.aufirst=Matthew&rft.date=2006-05-01&rft.volume=119&rft.issue=5+Pt+1&rft.spage=3147&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Chemotherapy with mitomycin c, ifosfamide, and cisplatin for recurrent or persistent cervical cancer. AN - 68585002; 16803499 AB - The efficacy and toxicity of mitomycin C (MMC), ifosfamide, and cisplatin in cervical cancer were evaluated. Between January 1997 and August 2003, 46 patients with locally recurrent, persistent, or disseminated cervical cancer were treated with MMC 6 mg/m(2), ifosfamide 3 g/m(2), and cisplatin 50 mg/m(2) (MIC regimen) repeated every 3 weeks (maximum six cycles). In eight patients (17%), the tumor involved the pelvis alone, in 11 (24%) the pelvis and extrapelvic sites, and 27 (59%) had only distant lesions. A total of 213 MIC cycles were administered (median six cycles per patient). Of the 44 evaluable patients, the overall response rate was 34% (9% complete and 25% partial responses). Median progression-free interval was 6 months (95% confidence interval [CI], 4-7 months), and overall survival was 10 months (95% CI, 6-14 months). Objective response was obtained in two patients (11%) with pelvic relapse within previously irradiated area and in 13 (50%) of those with extrapelvic lesions (P= 0.01). Leukopenia was seen in 59% of patients (grade 3 in 9%). Nonhematologic side effects were mild and relatively infrequent. In conclusion, MIC regimen provides satisfactory efficacy with acceptable toxicity in advanced cervical cancer patients. Better response is seen in lesions outside of the previously irradiated area. JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society AU - Serkies, K AU - Jassem, J AU - Dziadziuszko, R AD - Department of Oncology and Radiotherapy, Medical University of Gdańsk, 7 Debinki Street, 80-211 Gdańsk, Poland. onkol@amg.fda.pl PY - 2006 SP - 1152 EP - 1156 VL - 16 IS - 3 SN - 1048-891X, 1048-891X KW - Mitomycin KW - 50SG953SK6 KW - Cisplatin KW - Q20Q21Q62J KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Disease-Free Survival KW - Carcinoma, Adenosquamous -- blood KW - Humans KW - Anemia -- chemically induced KW - Retrospective Studies KW - Aged KW - Blood Cell Count KW - Neoplasms, Squamous Cell -- drug therapy KW - Neoplasms, Squamous Cell -- blood KW - Carcinoma, Adenosquamous -- drug therapy KW - Drug Evaluation KW - Survival Rate KW - Leukopenia -- chemically induced KW - Adult KW - Remission Induction -- methods KW - Middle Aged KW - Neoplasms, Squamous Cell -- mortality KW - Carcinoma, Adenosquamous -- mortality KW - Female KW - Uterine Cervical Neoplasms -- drug therapy KW - Neoplasm Recurrence, Local -- drug therapy KW - Uterine Cervical Neoplasms -- mortality KW - Mitomycin -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Uterine Cervical Neoplasms -- blood KW - Neoplasm Recurrence, Local -- mortality KW - Ifosfamide -- administration & dosage KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68585002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=Chemotherapy+with+mitomycin+c%2C+ifosfamide%2C+and+cisplatin+for+recurrent+or+persistent+cervical+cancer.&rft.au=Serkies%2C+K%3BJassem%2C+J%3BDziadziuszko%2C+R&rft.aulast=Serkies&rft.aufirst=K&rft.date=2006-05-01&rft.volume=16&rft.issue=3&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1048891X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determining a one-tailed upper limit for future sample relative reproducibility standard deviations. AN - 68109640; 16795922 AB - A formula was developed to determine a one-tailed 100p% upper limit for future sample percent relative reproducibility standard deviations (RSD(R),%= 100s(R)/y), where S(R) is the sample reproducibility standard deviation, which is the square root of a linear combination of the sample repeatability variance (s(r)2) plus the sample laboratory-to-laboratory variance (s(L)2), i.e., S(R) = s(L)2, and y is the sample mean. The future RSD(R),% is expected to arise from a population of potential RSD(R),% values whose true mean is zeta(R),% = 100sigmaR, where sigmaR and mu are the population reproducibility standard deviation and mean, respectively. JF - Journal of AOAC International AU - McClure, Foster D AU - Lee, Jung K AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, Department of Health and Human Services, College Park, MD 20740-3835, USA. foster.mcclure@cfsan.fda.gov PY - 2006 SP - 797 EP - 803 VL - 89 IS - 3 SN - 1060-3271, 1060-3271 KW - Index Medicus KW - Software KW - Programming Languages KW - Reproducibility of Results KW - Reference Standards KW - Calibration KW - Models, Statistical KW - Statistics as Topic KW - Models, Theoretical KW - Chemistry Techniques, Analytical -- methods KW - Drug Residues -- analysis KW - Data Interpretation, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determining+a+one-tailed+upper+limit+for+future+sample+relative+reproducibility+standard+deviations.&rft.au=McClure%2C+Foster+D%3BLee%2C+Jung+K&rft.aulast=McClure&rft.aufirst=Foster&rft.date=2006-05-01&rft.volume=89&rft.issue=3&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column cleanup and liquid chromatography with fluorescence detection. AN - 68108847; 16792061 AB - Mycotoxins are toxic secondary metabolites produced by certain molds and are common contaminants of many important food crops, such as grains, nuts, and spices. Some mycotoxins are found in fruits, vegetables, and botanical roots. These contaminants have a broad range of toxic effects, including carcinogenicity, immunotoxicity, neurotoxicity, and reproductive and developmental toxicity. The public health concerns related to both acute and chronic effects of mycotoxins in animals have prompted more than 100 countries to establish regulatory limits for some of the well-known mycotoxins, such as the aflatoxins (AFL). Our research focused on method development for 2 of these toxins, AFL and ochratoxin A (OTA), in ginseng and other selected botanical roots. Methods using an immunoaffinity column (IAC) cleanup, liquid chromatographic separation, and fluorescence detection were modified and evaluated. Two types of IAC cleanup were evaluated: IAC for AFL, and IAC for both AFL and OTA. Three derivatization techniques to enhance the fluorescence of the AFL were compared: precolumn trifluoroacetic acid, postcolumn bromination, and postcolumn ultraviolet irradiation. No derivatization was needed for OTA. Results for AFL using the single analyte IAC cleanup and the 3 derivatization techniques were all comparable for ginseng and for other roots such as ginger, licorice, and kava-kava. Recoveries of added AFL for ginseng at levels from 2 to 16 ng/g were about 80%. Using IAC cleanup for both AFL and OTA recoveries of added AFL for ginseng at 4-16 ng/g were about 70%, and for ginger, licorice, and kava-kava were about 60%. Recoveries of added OTA for ginseng, ginger, and echinacea at 4 ng/g were about 55%. JF - Journal of AOAC International AU - Trucksess, Mary AU - Weaver, Carol AU - Oles, Carolyn AU - D'Ovidio, Kathleen AU - Rader, Jeanne AD - U.S. Food and Drug Administration, 5300 Paint Branch Pkwy, College Park, MD, USA. mary.trucksess@fda.hhs.gov PY - 2006 SP - 624 EP - 630 VL - 89 IS - 3 SN - 1060-3271, 1060-3271 KW - Aflatoxins KW - 0 KW - Ochratoxins KW - ochratoxin A KW - 1779SX6LUY KW - Index Medicus KW - Ultraviolet Rays KW - Chemistry Techniques, Analytical -- methods KW - Plants, Medicinal -- metabolism KW - Chromatography, Affinity -- methods KW - Ochratoxins -- analysis KW - Aflatoxins -- analysis KW - Chromatography, Liquid -- methods KW - Spectrometry, Fluorescence -- methods KW - Panax -- metabolism KW - Ochratoxins -- isolation & purification KW - Aflatoxins -- isolation & purification KW - Plant Roots -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68108847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+aflatoxins+and+ochratoxin+A+in+ginseng+and+other+botanical+roots+by+immunoaffinity+column+cleanup+and+liquid+chromatography+with+fluorescence+detection.&rft.au=Trucksess%2C+Mary%3BWeaver%2C+Carol%3BOles%2C+Carolyn%3BD%27Ovidio%2C+Kathleen%3BRader%2C+Jeanne&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2006-05-01&rft.volume=89&rft.issue=3&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Food Prot. 2004 Aug;67(8):1782-6 [15330551] J Assoc Off Anal Chem. 1991 Jan-Feb;74(1):81-8 [2026580] Food Addit Contam. 1996 Jan;13(1):121-8 [8647302] Food Addit Contam. 1996 Oct;13(7):833-41 [8885323] J AOAC Int. 1997 Sep-Oct;80(5):941-9 [9325571] Food Addit Contam. 2006 Feb;23(2):174-80 [16449060] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation. AN - 68098527; 16786836 AB - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation. JF - Toxicology and industrial health AU - Xia, Qingsu AU - Chou, Ming W AU - Yin, Jun J AU - Howard, Paul C AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 147 EP - 156 VL - 22 IS - 4 SN - 0748-2337, 0748-2337 KW - Benz(a)Anthracenes KW - 0 KW - Fatty Acids KW - Polycyclic Aromatic Hydrocarbons KW - lipid peroxidation inhibitor KW - Dithiothreitol KW - T8ID5YZU6Y KW - Index Medicus KW - Drug Interactions KW - Fatty Acids -- pharmacology KW - Lipid Peroxidation -- radiation effects KW - Polycyclic Aromatic Hydrocarbons -- radiation effects KW - Benz(a)Anthracenes -- radiation effects KW - Dithiothreitol -- pharmacology KW - Lipid Peroxidation -- drug effects KW - Light UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68098527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Photoirradiation+of+representative+polycyclic+aromatic+hydrocarbons+and+twelve+isomeric+methylbenz%5Ba%5Danthracene+with+UVA+light%3A+formation+of+lipid+peroxidation.&rft.au=Xia%2C+Qingsu%3BChou%2C+Ming+W%3BYin%2C+Jun+J%3BHoward%2C+Paul+C%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2006-05-01&rft.volume=22&rft.issue=4&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-19 N1 - Date created - 2006-06-21 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Occupational health survey of farm workers by camp health aides. AN - 68016241; 16724790 AB - Little is known about the magnitude of occupational health problems among migrant farm workers. A community-based cross-sectional survey was conducted in two migrant farm worker communities: Homestead, Florida, and Kankakee, Illinois. Camp Health Aides (CHAs) interviewed 425 workers about job tasks, personal protective equipment (PPE), field sanitation, work exposures, and selected health conditions. Limited provision of personal protective equipment was reported among those reporting early re-entry tasks: 35% in Kankakee and 42% in Homestead were provided gloves, and 22% in Homestead and 0% in Kankakee were provided protective clothing. About two-thirds were provided toilet facilities and water for hand-washing. Workers reported high prevalences of health conditions consistent with exposure to ergonomic hazards and pesticides. The prevalence of back pain in the past 12 months was 39% in Homestead and 24% in Kankakee. Among Homestead participants, 35% experienced eye symptoms, while 31% reported skin symptoms. These symptoms were less prevalent among Kankakee participants (16% for both eye and skin symptoms). Specific areas of concern included back pain associated with heavy lifting and ladder work; eye and skin irritation associated with fertilizer application tasks and with working in fields during or after spraying of chemicals, especially early re-entry of sprayed fields; and skin irritation associated with a lack of access to hand-washing facilities. In both Kankakee and Homestead, better adherence to safety standards is needed, as well as greater efforts to implement solutions that are available to help prevent work-related musculoskeletal problems. JF - Journal of agricultural safety and health AU - Cameron, L AU - Lalich, N AU - Bauer, S AU - Booker, V AU - Bogue, H O AU - Samuels, S AU - Steege, A L AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 139 EP - 153 VL - 12 IS - 2 SN - 1074-7583, 1074-7583 KW - Pesticides KW - 0 KW - Index Medicus KW - Illinois -- epidemiology KW - Cross-Sectional Studies KW - Wounds and Injuries -- epidemiology KW - Humans KW - Health Surveys KW - Adult KW - Middle Aged KW - Hygiene KW - Adolescent KW - Male KW - Female KW - Florida -- epidemiology KW - Occupational Exposure KW - Back Pain -- epidemiology KW - Agriculture KW - Occupational Health KW - Agricultural Workers' Diseases -- epidemiology KW - Pesticides -- adverse effects KW - Protective Devices -- utilization KW - Back Pain -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68016241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=Occupational+health+survey+of+farm+workers+by+camp+health+aides.&rft.au=Cameron%2C+L%3BLalich%2C+N%3BBauer%2C+S%3BBooker%2C+V%3BBogue%2C+H+O%3BSamuels%2C+S%3BSteege%2C+A+L&rft.aulast=Cameron&rft.aufirst=L&rft.date=2006-05-01&rft.volume=12&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-02 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Follow-up study of medication errors reported to the vaccine adverse event reporting system (VAERS). AN - 67988841; 16711311 AB - A study was done to determine if the apparent medication errors found in the Vaccine Adverse Event Reporting System (VAERS) database are true errors, and if true errors are found, to determine what corrective action was taken. Furthermore, if a true error did not occur, we wanted to determine at what point the misinformation was entered into the system. The VAERS database was searched for reports received between July 1, 2001 and June 30, 2002 which had either been classified as "error" or the word "error" appeared in the text of the report. The database was also searched for reports which indicated that the measles-mumps-rubella (MMR), diphtheria-tetanus-pertussis (DTP), diphtheria-tetanus-acellular pertussis (DTaP) or diphtheria-tetanus-pertussis-haemophilus (DTPH) vaccinations had been administered at an age outside of the usual recommendation. A total of 119 reports of possible errors were found. Follow-up was successful in 102 (86%) cases. Additional information obtained showed that 26 cases were actual medication errors. Seventy-six cases were not actual medication errors; 9 cases were physician decisions, 37 cases were data entry errors and 30 cases were reporter errors. The nature of the actual errors was similar to those reported previously; wrong inoculum, improper interval, wrong route of administration, and overdose. Many errors could have been prevented by more attention to detail. Remedial action usually consisted of retraining. The new requirement that all medications be barcoded, purchasing products from different manufacturers and segregation of vials may help prevent vial confusion. JF - Southern medical journal AU - Varricchio, Frederick AU - Reed, John AU - VAERS Working Group AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville MD, USA. Varricchio@comcast.net ; VAERS Working Group Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 486 EP - 489 VL - 99 IS - 5 SN - 0038-4348, 0038-4348 KW - Vaccines KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Child KW - Adolescent KW - Vaccines -- adverse effects KW - Medication Errors -- classification KW - Adverse Drug Reaction Reporting Systems KW - Medication Errors -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67988841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Follow-up+study+of+medication+errors+reported+to+the+vaccine+adverse+event+reporting+system+%28VAERS%29.&rft.au=Varricchio%2C+Frederick%3BReed%2C+John%3BVAERS+Working+Group&rft.aulast=Varricchio&rft.aufirst=Frederick&rft.date=2006-05-01&rft.volume=99&rft.issue=5&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-04 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues in neurological risk assessment for occupational exposures: the Bay Bridge welders. AN - 67954572; 16332392 AB - The goal of occupational risk assessment is often to estimate excess lifetime risk for some disabling or fatal health outcome in relation to a fixed workplace exposure lasting a working lifetime. For sub-chronic or sub-clinical health effects measured as continuous variables, the benchmark dose method can be applied, but poses issues in defining impairment and in specifying acceptable levels of excess risk. Such risks may also exhibit a dose-rate effect and partial reversibility such that effects depend on how the dose is distributed over time. Neurological deficits as measured by a variety of increasingly sensitive neurobehavioral tests represent one such outcome, and the development of a parkinsonian syndrome among welders exposed to manganese fume presents a specific instance. Welders employed in the construction of piers for a new San Francisco-Oakland Bay Bridge in San Francisco were previously evaluated using a broad spectrum of tests. Results for four of those tests (Rey-Osterrieth Complex Figure Test, Working Memory Index, Stroop Color Word Test and Auditory Consonant Trigrams Test) were used in the benchmark dose procedure. Across the four outcomes analyzed, benchmark dose estimates were generally within a factor of 2.0, and decreased as the percentile of normal performance defining impairment increased. Estimated excess prevalence of impairment, defined as performance below the 5th percentile of normal, after 2 years of exposure at the current California standard (0.2 mg/m3, 8 h TWA), ranged 15-32% for the outcomes studied. Because these exposures occurred over a 1-2-year period, generalization to lifetime excess risk requires further consideration of the form of the exposure response and whether short-term responses can be generalized to equivalent 45-year period. These results indicate unacceptable risks at the current OSHA PEL for manganese (5.0 mg/m3, 15 min) and likely at the Cal OSHA PEL as well. JF - Neurotoxicology AU - Park, Robert M AU - Bowler, Rosemarie M AU - Eggerth, Donald E AU - Diamond, Emily AU - Spencer, Katie J AU - Smith, Donald AU - Gwiazda, Roberto AD - Risk Evaluation Branch, Education and Information Division, NIOSH, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. rhp9@cdc.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 373 EP - 384 VL - 27 IS - 3 SN - 0161-813X, 0161-813X KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Regression Analysis KW - Humans KW - Adult KW - Retrospective Studies KW - San Francisco -- epidemiology KW - Middle Aged KW - Memory, Short-Term -- physiology KW - Benchmarking KW - Time Factors KW - Male KW - Female KW - Proportional Hazards Models KW - Occupational Exposure -- statistics & numerical data KW - Manganese Poisoning -- epidemiology KW - Welding KW - Air Pollutants, Occupational -- toxicity KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67954572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Issues+in+neurological+risk+assessment+for+occupational+exposures%3A+the+Bay+Bridge+welders.&rft.au=Park%2C+Robert+M%3BBowler%2C+Rosemarie+M%3BEggerth%2C+Donald+E%3BDiamond%2C+Emily%3BSpencer%2C+Katie+J%3BSmith%2C+Donald%3BGwiazda%2C+Roberto&rft.aulast=Park&rft.aufirst=Robert&rft.date=2006-05-01&rft.volume=27&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaphylactoid reactions to Dextran 40 and 70: reports to the United States Food and Drug Administration, 1969 to 2004. AN - 67941310; 16678697 AB - Clinical dextrans, such as Dextran 40 and Dextran 70, are associated with anaphylactoid reactions caused by dextran-reactive immunoglobulin G antibodies. When infused immediately before clinical dextrans, dextran 1 significantly reduces the incidence of severe anaphylactoid reactions. The objective of the study was to describe the frequency and characteristics of reports submitted to the United States Food and Drug Administration (FDA) for anaphylaxis or anaphylactoid events after clinical dextran administration. We searched the FDA's Adverse Event Reporting System for reports associated with a clinical dextran and describing anaphylaxis/anaphylactoid reactions. Our case definition for a probable anaphylaxis/anaphylactoid event required signs or symptoms from at least two body systems, with at least one sign or symptom being hypotension, vasodilation, or respiratory difficulty, and onset within 60 minutes. Other reports were considered possible cases if the reporter specifically described the reaction as anaphylaxis or an anaphylactoid reaction. Premier RxMarket Advisor provided estimates of total US hospitalizations with clinical dextran or dextran 1 administration from 2000 to 2004, based on discharge billing data from a sample of US hospitals. The IMS National Sales Perspective provided estimates of total doses of dextrans sold in the United States from 1999 to 2004, based on volumes of dextrans sold in a sample of retail and nonretail outlets. The FDA received 366 clinical dextran adverse event reports from 1969 to 2004, of which 90 (24.6%) were anaphylaxis/anaphylactoid events. The ratio of hospitalizations where clinical dextran was administered to hospitalizations where dextran 1 was administered was 28.4:1. The expected ratio would be 1:1 if all clinical dextran patients had received dextran 1 pretreatment. The ratio of clinical dextran doses sold to dextran 1 doses sold in the United States was 38.6:1. A high proportion of adverse event reports for clinical dextrans described anaphylaxis or anaphylactoid reactions. Hospital discharge and product sales data suggest that dextran 1 has not been used consistently before clinical dextran administration in recent years. To reduce the risk of anaphylactoid reactions, physicians should consider routine administration of dextran 1 before the infusion of a clinical dextran. JF - Journal of vascular surgery AU - Zinderman, Craig E AU - Landow, Laurence AU - Wise, Robert P AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Rockville, MD 20852, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1004 EP - 1009 VL - 43 IS - 5 SN - 0741-5214, 0741-5214 KW - Dextrans KW - 0 KW - Index Medicus KW - United States KW - Airway Obstruction -- chemically induced KW - Airway Obstruction -- epidemiology KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Aged KW - Laryngeal Edema -- chemically induced KW - Risk KW - Cross-Sectional Studies KW - United States Food and Drug Administration KW - Laryngismus -- epidemiology KW - Aged, 80 and over KW - Laryngismus -- chemically induced KW - Adult KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Incidence KW - Hypersensitivity, Immediate -- chemically induced KW - Middle Aged KW - Netherlands KW - Male KW - Laryngeal Edema -- epidemiology KW - Female KW - Hypersensitivity, Immediate -- epidemiology KW - Anaphylaxis -- epidemiology KW - Anaphylaxis -- chemically induced KW - Dextrans -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67941310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vascular+surgery&rft.atitle=Anaphylactoid+reactions+to+Dextran+40+and+70%3A+reports+to+the+United+States+Food+and+Drug+Administration%2C+1969+to+2004.&rft.au=Zinderman%2C+Craig+E%3BLandow%2C+Laurence%3BWise%2C+Robert+P&rft.aulast=Zinderman&rft.aufirst=Craig&rft.date=2006-05-01&rft.volume=43&rft.issue=5&rft.spage=1004&rft.isbn=&rft.btitle=&rft.title=Journal+of+vascular+surgery&rft.issn=07415214&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal rats. AN - 67937069; 16675429 AB - Exposure of pregnant Long-Evans rats to elemental mercury (Hg0) vapor resulted in a significant accumulation of Hg in tissues of neonates. Because elevated Hg in neonatal tissues may adversely affect growth and development, we were interested in how rapidly Hg was eliminated from neonatal tissues. Pregnant rats were exposed to 1, 2, or 4 mg Hg0 vapor/m3 or air (controls) for 2 hr/day from gestation day 6 (GD6) through GD15. Neonatal brain, liver, and kidney were analyzed for total Hg at various times between birth and postnatal day 90 (PND90). Milk was analyzed for Hg between birth and weaning (PND21). Before weaning, the Hg levels in neonatal tissues were proportional to maternal exposure concentrations and were highest in kidney followed by liver and then brain. There was no elimination of Hg between birth and weaning, indicating that neonates were exposed continuously to elevated levels of Hg during postpartum growth and development. Consumption of milk from exposed dams resulted in a slight increase in kidney Hg concentration during this period. Unexpectedly, neonatal Hg accumulation increased rapidly after weaning. Increased Hg was measured in both control and exposed neonates and was attributed to consumption of NIH-07 diet containing trace levels of Hg. By PND90, tissue Hg levels equilibrated at concentrations similar to those in unexposed adult Long-Evans rats fed the same diet. These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg0 vapor. JF - Environmental health perspectives AU - Morgan, Daniel L AU - Price, Herman C AU - Fernando, Reshan AU - Chanda, Sushmita M AU - O'Connor, Robert W AU - Barone, Stanley S AU - Herr, David W AU - Beliles, Robert P AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. morgan3@niehs.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 735 EP - 739 VL - 114 IS - 5 SN - 0091-6765, 0091-6765 KW - Air Pollutants KW - 0 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Rats KW - Animals KW - Kidney -- metabolism KW - Rats, Long-Evans KW - Drinking Behavior KW - Liver -- metabolism KW - Brain -- metabolism KW - Feeding Behavior KW - Female KW - Pregnancy KW - Animals, Newborn KW - Mercury -- pharmacokinetics KW - Diet KW - Air Pollutants -- toxicity KW - Mercury -- toxicity KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67937069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Gestational+mercury+vapor+exposure+and+diet+contribute+to+mercury+accumulation+in+neonatal+rats.&rft.au=Morgan%2C+Daniel+L%3BPrice%2C+Herman+C%3BFernando%2C+Reshan%3BChanda%2C+Sushmita+M%3BO%27Connor%2C+Robert+W%3BBarone%2C+Stanley+S%3BHerr%2C+David+W%3BBeliles%2C+Robert+P&rft.aulast=Morgan&rft.aufirst=Daniel&rft.date=2006-05-01&rft.volume=114&rft.issue=5&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatrics. 2001 Jul;108(1):197-205 [11433078] Toxicol Sci. 2002 Apr;66(2):261-73 [11896293] Toxicol Appl Pharmacol. 2004 Jul 15;198(2):209-30 [15236954] Toxicol Sci. 2004 Nov;82(1):193-206 [15310857] Biol Neonate. 1972;21(3):239-44 [4656187] Arch Environ Health. 1976 Nov-Dec;31(6):302-9 [999343] Environ Health Perspect. 2005 Sep;113(9):1120-2 [16140614] Bull Environ Contam Toxicol. 1989 Feb;42(2):283-8 [2920236] Neurotoxicology. 1993 Spring;14(1):83-144 [8361683] Environ Res. 1994 Nov;67(2):196-208 [7982394] Analyst. 1995 Mar;120(3):765-70 [7741226] J Trace Elem Med Biol. 1996 Jun;10(2):61-7 [8829128] Toxicology. 1999 Oct 1;137(3):169-84 [10522497] Int J Biol Res Pregnancy. 1982;3(1):38-46 [7076335] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Formal treatment, self-help, or no treatment for alcohol-use disorders? Evidence from the National Household Survey on Drug Abuse. AN - 67906296; 16608145 AB - The purpose of this study was to examine further alcohol treatment choice by using data from a nationally representative sample of adults with alcohol-use disorders to test which of three models-sequential, multinomial, or nested best fit the data. The goals were to provide evidence about how this choice was made and to provide improved coefficient estimates, as well as to inform future analyses of treatment choice. Data from the 2000 National Household Survey of Drug Abuse include respondents ages 18-64 reporting symptoms consistent with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnoses of alcohol abuse or dependence. A nested multinomial framework is used to determine the preferred model and to estimate the effect of respondents' characteristics on the decisions to receive help and what kind of help to receive. A sequential model, in which the choice of whether to receive help is unaffected by the level of satisfaction afforded by the alternatives, best fit the data. Older respondents had higher odds of both receiving help and choosing self-help, and those with a DSM-IV diagnosis of abuse had lower odds of receiving help but higher odds of entering self-help. The decision to receive help for alcohol problems appears unaffected by the perceived differences between these two broad categories of alternatives: self-help or formal treatment. This result may indicate the need to provide more information on the full range of treatment options to those for whom self-help may not be sufficient. JF - Journal of studies on alcohol AU - Duffy, Sarah Q AU - Cowell, Alexander J AU - Council, Carol Lederhaus AU - Shi, Weihua AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1044, Rockville, Maryland 20857, USA. Sarah.Duffy@samhsa.hhs.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 363 EP - 372 VL - 67 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Severity of Illness Index KW - Health Services Needs and Demand KW - Motivation KW - Humans KW - Decision Making KW - Demography KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Prevalence KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Surveys and Questionnaires KW - Treatment Refusal -- statistics & numerical data KW - Self-Help Groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67906296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Formal+treatment%2C+self-help%2C+or+no+treatment+for+alcohol-use+disorders%3F+Evidence+from+the+National+Household+Survey+on+Drug+Abuse.&rft.au=Duffy%2C+Sarah+Q%3BCowell%2C+Alexander+J%3BCouncil%2C+Carol+Lederhaus%3BShi%2C+Weihua&rft.aulast=Duffy&rft.aufirst=Sarah&rft.date=2006-05-01&rft.volume=67&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pendimethalin exposure and cancer incidence among pesticide applicators. AN - 67870934; 16452832 AB - Pendimethalin, a widely used herbicide, has been classified as a group C possible human carcinogen by the U.S. Environmental Protection Agency. We evaluated the incidence of cancer in relation to reported pendimethelin use among pesticide applicators in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Information on pesticide use came from two questionnaires (enrollment and take-home). The present analysis includes 9089 pendimethalin-exposed and 15,285 nonpendimethalin-exposed pesticide applicators with complete information on pendimethalin use and covariates from a take-home questionnaire. We conducted Poisson regression analyses to evaluate the association of pendimethalin exposure with cancer incidence (mean follow-up = 7.5 years) using two exposure metrics: tertiles of lifetime days of exposure and tertiles of intensity-weighted lifetime days of exposure. Overall cancer incidence did not increase with increasing lifetime pendimethalin use, and there was no clear evidence of an association between pendimethalin use and risks for specific cancers. The risk for rectal cancer rose with increasing lifetime pendimethalin exposure when using nonexposed as the reference (rate ratio = 4.3; 95% confidence interval = 1.5-12.7 for the highest exposed subjects; P for trend = 0.007), but the association was attenuated when using the low exposed as the referent group (P for trend = 0.08). Similar patterns for rectal cancer were observed when using intensity-weighted exposure-days. The number of rectal cancer cases among the pendimethalin-exposed was small (n = 19). There was some evidence for an elevated risk for lung cancer, but the excess occurred only in the highest exposure category for lifetime pendimethalin exposure. The trends for lung cancer risk were inconsistent for different exposure metrics. We did not find a clear association of lifetime pendimethalin exposure either with overall cancer incidence or with specific cancer sites. JF - Epidemiology (Cambridge, Mass.) AU - Hou, Lifang AU - Lee, Won Jin AU - Rusiecki, Jennifer AU - Hoppin, Jane A AU - Blair, Aaron AU - Bonner, Matthew R AU - Lubin, Jay H AU - Samanic, Claudine AU - Sandler, Dale P AU - Dosemeci, Mustafa AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 302 EP - 307 VL - 17 IS - 3 SN - 1044-3983, 1044-3983 KW - Aniline Compounds KW - 0 KW - pendimethalin KW - VL6L14C06U KW - Index Medicus KW - Prospective Studies KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Aniline Compounds -- poisoning KW - Environmental Exposure -- analysis KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67870934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Pendimethalin+exposure+and+cancer+incidence+among+pesticide+applicators.&rft.au=Hou%2C+Lifang%3BLee%2C+Won+Jin%3BRusiecki%2C+Jennifer%3BHoppin%2C+Jane+A%3BBlair%2C+Aaron%3BBonner%2C+Matthew+R%3BLubin%2C+Jay+H%3BSamanic%2C+Claudine%3BSandler%2C+Dale+P%3BDosemeci%2C+Mustafa%3BAlavanja%2C+Michael+C+R&rft.aulast=Hou&rft.aufirst=Lifang&rft.date=2006-05-01&rft.volume=17&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-31 N1 - Date created - 2006-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Agric Food Chem. 2001 May;49(5):2198-206 [11368577] Br J Cancer. 1985 Aug;52(2):259-70 [4027168] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Int J Cancer. 2004 Jan 20;108(3):433-42 [14648711] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] IARC Sci Publ. 1980;(32):5-338 [7216345] Environ Res. 1999 Feb;80(2 Pt 1):180-6 [10092411] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Int J Epidemiol. 1996 Dec;25(6):1117-24 [9027514] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Bull Environ Contam Toxicol. 1994 Apr;52(4):498-504 [8167442] Scand J Work Environ Health. 1993 Dec;19(6):382-9 [8153589] Cancer. 1993 Nov 1;72(9):2543-9 [8402474] Scand J Work Environ Health. 1992 Jun;18(3):201-4 [1615295] Lancet. 1991 Oct 26;338(8774):1027-32 [1681353] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Br J Ind Med. 1988 Feb;45(2):98-105 [3342201] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses. AN - 67843449; 16485136 AB - The double-strand break DNA repair pathway has been implicated in breast carcinogenesis. We evaluated the association between 19 polymorphisms in seven genes in this pathway (XRCC2, XRCC3, BRCA2, ZNF350, BRIP1, XRCC4, LIG4) and breast cancer risk in two population-based studies in USA (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls). These data suggested weak associations with breast cancer risk for XRCC3 T241M and IVS7-14A>G (pooled odds ratio (95% confidence interval): 1.18 (1.04-1.34) and 0.85 (0.73-0.98) for homozygous variant vs wild-type genotypes, respectively), and for an uncommon variant in ZNF350 S472P (1.24 (1.05-1.48)), with no evidence for study heterogeneity. The remaining variants examined had no significant relationships to breast cancer risk. Meta-analyses of studies in Caucasian populations, including ours, provided some support for a weak association for homozygous variants for XRCC3 T241M (1.16 (1.04-1.30); total of 10,979 cases and 10,423 controls) and BRCA2 N372H (1.13 (1.10-1.28); total of 13,032 cases and 13,314 controls), and no support for XRCC2 R188H (1.06 (0.59-1.91); total of 8,394 cases and 8,404 controls). In conclusion, the genetic variants evaluated are unlikely to have a substantial overall association with breast cancer risk; however, weak associations are possible for XRCC3 (T241M and IVS7-14A>G), BRCA2 N372H, and ZNF350 S472P. Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes. JF - Human genetics AU - García-Closas, Montserrat AU - Egan, Kathleen M AU - Newcomb, Polly A AU - Brinton, Louise A AU - Titus-Ernstoff, Linda AU - Chanock, Stephen AU - Welch, Robert AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Bardin-Mikolajczak, Alicja AU - Struewing, Jeffery P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952-7234, USA. montse@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 376 EP - 388 VL - 119 IS - 4 SN - 0340-6717, 0340-6717 KW - Cell Cycle Proteins KW - 0 KW - DNA, Neoplasm KW - DNA-Binding Proteins KW - Index Medicus KW - United States KW - Humans KW - DNA-Binding Proteins -- genetics KW - Aged KW - Genotype KW - Cell Cycle Proteins -- genetics KW - Poland KW - Adult KW - Case-Control Studies KW - Genes, Tumor Suppressor -- physiology KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Polymorphism, Genetic KW - DNA, Neoplasm -- genetics KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67843449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genetics&rft.atitle=Polymorphisms+in+DNA+double-strand+break+repair+genes+and+risk+of+breast+cancer%3A+two+population-based+studies+in+USA+and+Poland%2C+and+meta-analyses.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BEgan%2C+Kathleen+M%3BNewcomb%2C+Polly+A%3BBrinton%2C+Louise+A%3BTitus-Ernstoff%2C+Linda%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BBardin-Mikolajczak%2C+Alicja%3BStruewing%2C+Jeffery+P&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2006-05-01&rft.volume=119&rft.issue=4&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Human+genetics&rft.issn=03406717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mixed-effect models for evaluating multiple measures of atrazine exposure among custom applicators. AN - 67836080; 16595379 AB - The exposure of custom (or commercial) applicators to the herbicide atrazine was measured in environmental (hand wash and dermal patch) and biological (urine and saliva) samples. Surrogate exposure data, such as amount of atrazine sprayed, were also collected. A systematic sampling design was used that included both spray and nonspray days. Fifteen applicators were sampled 5 to 7 days each during a 6-week spring spray season for a total of 89 sampled days. Mixed-effect regression modeling was used to examine the relationship among the surrogate, environmental, and biological atrazine exposure measures. Surrogate measures of atrazine application (either kg of atrazine sprayed or spray atrazine [yes/no]) were significantly associated with increased levels of atrazine or atrazine equivalents (eq) in hand wash, thigh patch, 4-6 p.m. saliva, and 24-hour urine samples. Two days of spraying information (day of sampling and day before sampling) were needed to optimally estimate atrazine biomarkers in the biological samples, whereas only 1 day of spraying information (day of sampling) was needed to estimate atrazine levels in the environmental samples. Thigh and hand atrazine exposures were significantly associated with increased atrazine and atrazine eq. levels in the 4-6 p.m. saliva and 24-hour urine samples, respectively. Levels of 4-6 p.m. salivary atrazine were also significantly associated with increased levels of 24-hour urinary atrazine eq. Atrazine levels in the 4-6 p.m. saliva samples tracked most closely with evening and next morning urinary atrazine eq. Number of days into the study at the time of sample collection predicted urinary and salivary atrazine levels independent of other fixed effects. These results indicate that either surrogate, environmental, or biological exposure measures can be used in appropriately specified models to estimate urinary and salivary atrazine biomarker levels. JF - Journal of occupational and environmental hygiene AU - Hines, Cynthia J AU - Deddens, James A AU - Lu, Chensheng AU - Fenske, Richard AU - Striley, Cynthia A F AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. chines@cdc.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 274 EP - 283 VL - 3 IS - 5 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Herbicides KW - Atrazine KW - QJA9M5H4IM KW - Index Medicus KW - Hand Disinfection KW - Saliva -- chemistry KW - Humans KW - Biomarkers -- urine KW - Time Factors KW - Models, Biological KW - Male KW - Herbicides -- urine KW - Herbicides -- analysis KW - Air Pollutants, Occupational -- analysis KW - Atrazine -- urine KW - Atrazine -- analysis KW - Air Pollutants, Occupational -- urine KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67836080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Mixed-effect+models+for+evaluating+multiple+measures+of+atrazine+exposure+among+custom+applicators.&rft.au=Hines%2C+Cynthia+J%3BDeddens%2C+James+A%3BLu%2C+Chensheng%3BFenske%2C+Richard%3BStriley%2C+Cynthia+A+F&rft.aulast=Hines&rft.aufirst=Cynthia&rft.date=2006-05-01&rft.volume=3&rft.issue=5&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-15 N1 - Date created - 2006-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microbiological quality of randomly selected ready-to-eat foods sampled between 2003 and 2005 in Wales, UK. AN - 67834065; 16503065 AB - Since 1995, the publicly funded ready-to-eat food sampling and examination activities in Wales have been coordinated and structured, using a novel approach for the identification of samples and premises. The latest set of data from this surveillance system reports the results from 3391 ready-to-eat foods sampled between November 2003 and March 2005. During this seventeen-month period all samples were examined for aerobic colony count, Escherichia coli, Listeria spp., Bacillus cereus, Salmonella, Staphylococcus aureus and Listeria monocytogenes. The food types with the poorest microbiological quality were cream cakes, custard slices and egg mayonnaise sandwiches. The food type with the best microbiological quality was dried fruit. In conclusion, the results indicate that, in general terms, the ready-to-eat food types sampled and examined in this period posed little bacterial hazard to consumers. JF - International journal of food microbiology AU - Meldrum, R J AU - Smith, R M M AU - Ellis, P AU - Garside, J AU - Welsh Food Microbiological Forum AD - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, United Kingdom. richard.meldrum@nphs.wales.nhs.uk ; Welsh Food Microbiological Forum Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 397 EP - 400 VL - 108 IS - 3 SN - 0168-1605, 0168-1605 KW - Index Medicus KW - Consumer Product Safety KW - Escherichia coli -- isolation & purification KW - Staphylococcus aureus -- isolation & purification KW - Humans KW - Food Analysis KW - Colony Count, Microbial KW - Salmonella -- isolation & purification KW - Wales KW - Bacillus cereus -- isolation & purification KW - Listeria -- isolation & purification KW - Food Microbiology KW - Food Contamination -- analysis KW - Food -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67834065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Microbiological+quality+of+randomly+selected+ready-to-eat+foods+sampled+between+2003+and+2005+in+Wales%2C+UK.&rft.au=Meldrum%2C+R+J%3BSmith%2C+R+M+M%3BEllis%2C+P%3BGarside%2C+J%3BWelsh+Food+Microbiological+Forum&rft.aulast=Meldrum&rft.aufirst=R&rft.date=2006-05-01&rft.volume=108&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=01681605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - From Single-Parent Families to Stepfamilies. Is the Transition Associated With Adolescent Alcohol Initiation? AN - 21327119; 11628911 AB - This study addresses two questions: Is stepfamily formation associated with the likelihood that adolescents will initiate alcohol use, and if so, does this association differ by the type of single-parent families from which adolescents move or the type of stepfamilies to which they move? The author found that adolescents who moved to stepfamilies from single-parent families had an elevated risk of initiating alcohol use. A transition from a divorced single-parent family to a stepfamily is associated with an increase in alcohol initiation among boys, but a transition from an unwed single-parent family to a stepfamily is not. In contrast, girls who transition from an unwed single-parent family to a stepfamily show an elevated likelihood of initiating alcohol use, whereas those who transition from divorced single-parent families do not. Adolescents who move to cohabiting stepfamilies do not respond differently than do adolescents who move to married stepfamilies regardless of gender. JF - Journal of Family Issues AU - Kirby, James B AD - Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 685 EP - 711 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 27 IS - 5 SN - 0192-513X, 0192-513X KW - Risk Abstracts KW - Alcohol KW - Gender KW - Adolescents KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21327119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Issues&rft.atitle=From+Single-Parent+Families+to+Stepfamilies.+Is+the+Transition+Associated+With+Adolescent+Alcohol+Initiation%3F&rft.au=Kirby%2C+James+B&rft.aulast=Kirby&rft.aufirst=James&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Issues&rft.issn=0192513X&rft_id=info:doi/10.1177%2F0192513X05284855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alcohol; Gender; Adolescents DO - http://dx.doi.org/10.1177/0192513X05284855 ER - TY - JOUR T1 - Comparing median lethal concentration values using confidence interval overlap or ratio tests AN - 21049776; 7077491 AB - Experimenters in toxicology often compare the concentration-response relationship between two distinct populations using the median lethal concentration (LC50). This comparison is sometimes done by calculating the 95% confidence interval for the LC50 for each population, concluding that no significant difference exists if the two confidence intervals overlap. A more appropriate test compares the ratio of the LC50s to 1 or the log(LC50 ratio) to 0. In this ratio test, we conclude that no difference exists in LC50s if the confidence interval for the ratio of the LC50s contains 1 or the confidence interval for the log(LC50 ratio) contains 0. A Monte Carlo simulation study was conducted to compare the confidence interval overlap test to the ratio test. The confidence interval overlap test performs substantially below the nominal alpha = 0.05 level, closer to p = 0.005; therefore, it has considerably less power for detecting true differences compared to the ratio test. The ratio-based method exhibited better type I error rates and superior power properties in comparison to the confidence interval overlap test. Thus, a ratio-based statistical procedure is preferred to using simple overlap of two independently derived confidence intervals. JF - Environmental Toxicology and Chemistry AU - Wheeler, M W AU - Park, R M AU - Bailer, A J AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS-15, Cincinnati, Ohio 45226, USA, mwheeler@cdc.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1441 EP - 1444 VL - 25 IS - 5 SN - 0730-7268, 0730-7268 KW - Toxicology Abstracts; Pollution Abstracts KW - Monte Carlo simulation KW - Statistics KW - Dose-response effects KW - Toxicology KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21049776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Comparing+median+lethal+concentration+values+using+confidence+interval+overlap+or+ratio+tests&rft.au=Wheeler%2C+M+W%3BPark%2C+R+M%3BBailer%2C+A+J&rft.aulast=Wheeler&rft.aufirst=M&rft.date=2006-05-01&rft.volume=25&rft.issue=5&rft.spage=1441&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Statistics; Dose-response effects; Toxicology ER - TY - JOUR T1 - Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent AN - 20857998; 8368130 AB - The purpose of this work was to investigate the use of an intravascular contrast agent to determine perfusion kinetics in skeletal muscle. A two-compartment kinetic model was used to represent the flux of contrast agent between the intravascular space and extravascular extracellular space (EES). The relationship between the image signal-to-noise ratio (SNR) and errors in estimating permeability surface area product (Ktrans), interstitial volume (ve), and plasma volume (vp) for linear and nonlinear curve-fitting methods was estimated from Monte Carlo simulations. Similar results were obtained for both methods. For an image SNR of 60, the estimated errors in these parameters were 10%, 22%, and 17%, respectively. In vivo experiments were conducted in rabbits to examine physiological differences between these parameters in the soleus (SOL) and tibialis anterior (TA) muscles in the hind limb. Values for Ktrans were significantly higher in the SOL (3.2 - 0.9 vs. 2.0 - 0.5 X 10-3 min-1), as were values for vp (3.4 - 0.8 vs. 2.1 - 0.7%). Differences in ve for the two muscles (8.7 - 2.2 vs. 8.5 - 1.6%) were not found to be significant. These results demonstrate that relevant physiological metrics can be calculated in skeletal muscle using MRI with an intravascular contrast agent. JF - Magnetic Resonance in Medicine AU - Faranesh, Anthony Z AU - Kraitchman, Dara L AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, faranesh@stanford.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1114 EP - 1123 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Monte Carlo simulation KW - Permeability KW - Perfusion KW - Limbs KW - Surface area KW - Kinetics KW - Magnetic resonance imaging KW - Contrast media KW - N.M.R. KW - Skeletal muscle KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Measurement+of+kinetic+parameters+in+skeletal+muscle+by+magnetic+resonance+imaging+with+an+intravascular+agent&rft.au=Faranesh%2C+Anthony+Z%3BKraitchman%2C+Dara+L%3BMcVeigh%2C+Elliot+R&rft.aulast=Faranesh&rft.aufirst=Anthony&rft.date=2006-05-01&rft.volume=55&rft.issue=5&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20884 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skeletal muscle; Contrast media; Kinetics; Magnetic resonance imaging; Surface area; Models; N.M.R.; Limbs; Monte Carlo simulation; Permeability; Perfusion DO - http://dx.doi.org/10.1002/mrm.20884 ER - TY - JOUR T1 - Associations between metals and the blue mesogleal protein of Cassiopea xamachana AN - 20727904; 7949729 AB - The blue mesogleal pigment of the symbiotic jellyfish, Cassiopea xamachana Bigelow, 1882, is composed of two subunits, a larger glycosylated (35 kDa) moiety and a non-glycosylated (30 kDa) variant in lower concentration. In solution, the subunits assemble in large complexes of at least 10 super(6) kDa. The pigment, known as Cassio Blue, appears to mitigate excessive solar radiation while allowing the passage of the wavelengths optimal for photosynthesis by the numerous algal symbionts in the mesoglea of the jellyfish. The pigment is an abundant protein comprising about 6% of all animal protein in the whole jellyfish and about 33% of all animal protein in the oral appendages. The protein also contains a diverse array of metals, notably Ag, Ca, Cu, Fe, Mg, and Zn, with traces of others. Metal stoichiometry varies among isolates averaging about 1 mol of all metals, taken together, for each mole of the pigment. Given the broad array of metals present, the pigment may also serve another purpose, for example, as a metal reservoir or trap. Few other proteins are associated with such a spectrum of metals. In addition, the amino acid sequences of the pigment tryptic peptides have no reasonable matches in any of the sequence databases. Our findings, taken as a whole, suggest that the Cassio pigment is indeed unusual and is likely a representative of a novel category of proteins, the original member of which is rpulFKz1, a chromoprotein endowed with Frizzled and Kringle domains. JF - Marine Biology AU - Phelan, MA AU - Matta, J L AU - Reyes, Y M AU - Fernando, R AU - Boykins, R A AU - Blanquet, R S AD - FDA, Bethesda, MD, 20892, USA, michael@michaelphelan.us Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 307 EP - 312 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de] VL - 149 IS - 2 SN - 0025-3162, 0025-3162 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Metals KW - Symbionts KW - Photosynthesis KW - Frizzled protein KW - Copper KW - Appendages KW - Solar radiation KW - Cassiopea xamachana KW - Databases KW - Food sources KW - Pigments KW - Zinc KW - chromoproteins KW - Proteins KW - Tryptic peptides KW - Peptides KW - Wavelength KW - Algae KW - Amino acid sequence KW - Q1 08483:Species interactions: general KW - K 03490:Miscellaneous KW - O 4080:Pollution - Control and Prevention KW - Q5 08501:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Biology&rft.atitle=Associations+between+metals+and+the+blue+mesogleal+protein+of+Cassiopea+xamachana&rft.au=Phelan%2C+MA%3BMatta%2C+J+L%3BReyes%2C+Y+M%3BFernando%2C+R%3BBoykins%2C+R+A%3BBlanquet%2C+R+S&rft.aulast=Phelan&rft.aufirst=MA&rft.date=2006-05-01&rft.volume=149&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Marine+Biology&rft.issn=00253162&rft_id=info:doi/10.1007%2Fs00227-005-0189-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Symbionts; Proteins; Peptides; Solar radiation; Amino acid sequence; Metals; Photosynthesis; Frizzled protein; Appendages; Copper; Databases; Pigments; Food sources; Zinc; chromoproteins; Tryptic peptides; Wavelength; Algae; Cassiopea xamachana; Marine DO - http://dx.doi.org/10.1007/s00227-005-0189-9 ER - TY - JOUR T1 - Fractionation of Serum Components Using Nanoporous Substrates AN - 20358196; 7599242 AB - Numerous previously uncharacterized molecules resident within the low molecular weight circulatory proteome may provide a picture of the ongoing pathophysiology of an organism. Recently, proteomic signatures composed of low molecular weight molecules have been identified using mass spectrometry combined with bioinformatic algorithms. Attempts to sequence and identify the molecules that underpin the fingerprints are currently underway. The finding that many of these low molecular weight molecules may exist bound to circulating carrier proteins affords a new opportunity for fractionation and separation techniques prior to mass spectrometry-based analysis. In this study we demonstrate a method whereby nanoporous substrates may be used for the facile and reproducible fractionation and selective binding of the serum-based biomarker material, including subcellular proteins found within the serum. Aminopropyl-coated nanoporous silicon, when exposed to serum, can deplete serum of proteins and yield a serum with a distinct, altered MS profile. Additionally, aminopropyl-coated, nanoporous controlled-pore glass beads are able to bind a subset of serum proteins and release them with stringent elution. The eluted proteins have distinct MS profiles, gel electrophoresis profiles, and differential peptide sequence identities, which vary based on the size of the nanopores. These material surfaces could be employed in strategies for the harvesting and preservation of labile and carrier-protein-bound molecules in the blood. JF - Bioconjugate Chemistry AU - Geho, D AU - Cheng, MM-C AU - Killian, K AU - Lowenthal, M AU - Ross, S AU - Frogale, K AU - Nijdam, J AU - Lahar, N AU - Johann, D AU - Herrmann, P AU - Whiteley, G AU - Ferrari, M AU - Petricoin, E AU - Liotta, L AD - Laboratory of Pathology, FDA-NCI Clinical Proteomics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 654 EP - 661 VL - 17 IS - 3 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Algorithms KW - biomarkers KW - Gel electrophoresis KW - Mass spectroscopy KW - Serum proteins KW - Blood KW - Preservation KW - proteomics KW - Bioinformatics KW - Harvesting KW - Separation techniques KW - Glass beads KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Fractionation+of+Serum+Components+Using+Nanoporous+Substrates&rft.au=Geho%2C+D%3BCheng%2C+MM-C%3BKillian%2C+K%3BLowenthal%2C+M%3BRoss%2C+S%3BFrogale%2C+K%3BNijdam%2C+J%3BLahar%2C+N%3BJohann%2C+D%3BHerrmann%2C+P%3BWhiteley%2C+G%3BFerrari%2C+M%3BPetricoin%2C+E%3BLiotta%2C+L&rft.aulast=Geho&rft.aufirst=D&rft.date=2006-05-01&rft.volume=17&rft.issue=3&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0503364 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Silicon; Algorithms; biomarkers; Mass spectroscopy; Gel electrophoresis; Serum proteins; Blood; Bioinformatics; proteomics; Preservation; Separation techniques; Harvesting; Glass beads DO - http://dx.doi.org/10.1021/bc0503364 ER - TY - JOUR T1 - Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus AN - 20155885; 6811717 AB - The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) and CD4 T cells and measured [ super(3)H]thymidine incorporation to determine the factors responsible for RSV-induced T-cell suppression. These two cell types were sufficient for RSV-induced suppression of T-cell proliferation in response to cytomegalovirus or Staphylococcus enterotoxin B. Suppressive activity was transferable with supernatants from RSV-infected MDDC and was not due to transfer of live virus or RSV F (fusion) protein. Supernatants from RSV-infected MDDC, but not MDDC exposed to UV-killed RSV or mock conditions, contained alpha interferon (IFN- alpha ; median, 43 pg/ml) and IFN- lambda (approximately 1 to 20 ng/ml). Neutralization of IFN- alpha with monoclonal antibody (MAb) against one of its receptor chains, IFNAR2, or of IFN- lambda with MAb against either of its receptor chains, IFN- lambda R1 (interleukin 28R [IL-28R]) or IL-10R2, had a modest effect. In contrast, blocking the two receptors together markedly reduced or completely blocked the RSV-induced suppression of CD4 T-cell proliferation. Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons. JF - Journal of Virology AU - Chi, Bo AU - Dickensheets, Harold L AU - Spann, Kirsten M AU - Alston, Marc A AU - Luongo, Cindy AU - Dumoutier, Laure AU - Huang, Jiaying AU - Renauld, Jean-Christophe AU - Kotenko, Sergei V AU - Roederer, Mario AU - Beeler, Judy A AU - Donnelly, Raymond P AU - Collins, Peter L AU - Rabin, Ronald L AD - Center for Biologics Evaluation and Research. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Ludwig Institute for Cancer Research, Brussels Branch, and Experimental Medicine Unit, Universite de Louvain, Brussels, Belgium. Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 5032 EP - 5040 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Monoclonal antibodies KW - Staphylococcus KW - Cytomegalovirus KW - Respiratory syncytial virus KW - Dendritic cells KW - CD4 antigen KW - alpha -Interferon KW - Lymphocytes T KW - Monocytes KW - Vaccines KW - Fusion protein KW - enterotoxin B KW - J 02350:Immunology KW - V 22095:Interferon KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20155885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Alpha+and+Lambda+Interferon+Together+Mediate+Suppression+of+CD4+T+Cells+Induced+by+Respiratory+Syncytial+Virus&rft.au=Chi%2C+Bo%3BDickensheets%2C+Harold+L%3BSpann%2C+Kirsten+M%3BAlston%2C+Marc+A%3BLuongo%2C+Cindy%3BDumoutier%2C+Laure%3BHuang%2C+Jiaying%3BRenauld%2C+Jean-Christophe%3BKotenko%2C+Sergei+V%3BRoederer%2C+Mario%3BBeeler%2C+Judy+A%3BDonnelly%2C+Raymond+P%3BCollins%2C+Peter+L%3BRabin%2C+Ronald+L&rft.aulast=Chi&rft.aufirst=Bo&rft.date=2006-05-01&rft.volume=80&rft.issue=10&rft.spage=5032&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dendritic cells; CD4 antigen; Monoclonal antibodies; alpha -Interferon; Lymphocytes T; Fusion protein; Vaccines; Monocytes; enterotoxin B; Respiratory syncytial virus; Staphylococcus; Cytomegalovirus ER - TY - JOUR T1 - Effect of Conventional and Organic Production Practices on the Prevalence and Antimicrobial Resistance of Campylobacter spp. in Poultry AN - 19977045; 6812863 AB - Intestinal tracts of broilers and turkeys from 10 conventional broiler farms and 10 conventional turkey farms, where antimicrobials were routinely used, and from 5 organic broiler farms and 5 organic turkey farms, where antimicrobials had never been used, were collected and cultured for Campylobacter species. A total of 694 Campylobacter isolates from the conventional and organic poultry operations were tested for antimicrobial resistance to nine antimicrobial agents by the agar dilution method. Although Campylobacter species were highly prevalent in both the conventional and organic poultry operations, the antimicrobial resistance rates were significantly different between the organic operations and the conventional operations. Less than 2% of Campylobacter strains isolated from organically raised poultry were resistant to fluoroquinolones, while 46% and 67% of Campylobacter isolates from conventionally raised broilers and conventionally raised turkeys, respectively, were resistant to these antimicrobials. In addition, a high frequency of resistance to erythromycin (80%), clindamycin (64%), kanamycin (76%), and ampicillin (31%) was observed among Campylobacter isolates from conventionally raised turkeys. None of the Campylobacter isolates obtained in this study was resistant to gentamicin, while a large number of the isolates from both conventional and organic poultry operations were resistant to tetracycline. Multidrug resistance was observed mainly among Campylobacter strains isolated from the conventional turkey operation (81%). Findings from this study clearly indicate the influence of conventional and organic poultry production practices on antimicrobial resistance of Campylobacter on poultry farms. JF - Applied and Environmental Microbiology AU - Luangtongkum, Taradon AU - Morishita, Teresa Y AU - Ison, Aaron J AU - Huang, Shouxiong AU - McDermott, Patrick F AU - Zhang, Qijing AD - Department of Veterinary Preventive Medicine, Ohio State University, 1920 Coffey Road, Columbus, Ohio 43210. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Ohio State University, 1680 Madison Avenue, Wooster, Ohio 44691. Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3600 EP - 3607 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 5 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Clindamycin KW - Poultry KW - Farms KW - Fluoroquinolones KW - Drug resistance KW - Campylobacter KW - Ampicillin KW - Kanamycin KW - Erythromycin KW - Tetracyclines KW - Antimicrobial agents KW - Gentamicin KW - Intestine KW - Multidrug resistance KW - Antimicrobial resistance KW - J 02410:Animal Diseases KW - A 01064:Microbial resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19977045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Effect+of+Conventional+and+Organic+Production+Practices+on+the+Prevalence+and+Antimicrobial+Resistance+of+Campylobacter+spp.+in+Poultry&rft.au=Luangtongkum%2C+Taradon%3BMorishita%2C+Teresa+Y%3BIson%2C+Aaron+J%3BHuang%2C+Shouxiong%3BMcDermott%2C+Patrick+F%3BZhang%2C+Qijing&rft.aulast=Luangtongkum&rft.aufirst=Taradon&rft.date=2006-05-01&rft.volume=72&rft.issue=5&rft.spage=3600&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Agar; Poultry; Clindamycin; Farms; Fluoroquinolones; Drug resistance; Ampicillin; Kanamycin; Tetracyclines; Erythromycin; Antimicrobial agents; Gentamicin; Intestine; Multidrug resistance; Antimicrobial resistance; Campylobacter ER - TY - JOUR T1 - Oncolytic Viruses Derived from the gamma 34.5-Deleted Herpes Simplex Virus Recombinant R3616 Encode a Truncated UL3 Protein AN - 19770315; 6837260 AB - Replication-competent herpes simplex virus (HSV-1) mutants are used in clinical trials in the experimental treatment of cancer. Mutants G207, HSV1716, NV1020, and Oncovex GM-CSF share in common a defect in one or both copies of the gene encoding the neurovirulence factor, ICP34.5, and are thus neuroattenuated. These viruses are acknowledged to differ from one another (a) in the specific types of mutations intentionally introduced during their derivation and (b) in the inherent genetic differences retained from the different parent strains used in their construction. Unintended mutations are expected to emerge at some low frequency during the selection for and passage of mutant viruses. Here we demonstrate that during the construction of the oncolytic virus R3616, a nonsense mutation arose in an untargeted region of the HSV-1 genome that resulted in a substantial truncation of the viral protein known as UL3. This report is the first published documentation that oncolytic herpesviruses developed and used in clinical trials contain adventitious mutations. The implications of these findings for the characterization and development of vectors proposed for use in clinical trials are discussed. JF - Molecular Therapy AU - Dambach, Megan J AU - Trecki, Jordan AU - Martin, Natalia AU - Markovitz, Nancy S AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, nancy.markovitz@fda.hhs.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 891 EP - 898 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 5 SN - 1525-0016, 1525-0016 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - oncolytic virus KW - herpes simplex virus-1 ICP34.5 protein KW - herpes simplex virus-1 UL3 protein KW - cancer vaccine KW - gene therapy KW - nonsense mutation KW - genotypic characterization KW - neurotoxicity KW - DNA mutational analysis KW - genetic stability KW - Genomes KW - Herpes simplex virus 1 KW - Granulocyte-macrophage colony-stimulating factor KW - Neurovirulence KW - Oncolysis KW - Clinical trials KW - Cancer KW - Nonsense mutation KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - W3 33374:Antitumor agents KW - W 30965:Miscellaneous, Reviews KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Oncolytic+Viruses+Derived+from+the+gamma+34.5-Deleted+Herpes+Simplex+Virus+Recombinant+R3616+Encode+a+Truncated+UL3+Protein&rft.au=Dambach%2C+Megan+J%3BTrecki%2C+Jordan%3BMartin%2C+Natalia%3BMarkovitz%2C+Nancy+S&rft.aulast=Dambach&rft.aufirst=Megan&rft.date=2006-05-01&rft.volume=13&rft.issue=5&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1016%2Fj.ymthe.2006.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Neurovirulence; Granulocyte-macrophage colony-stimulating factor; Oncolysis; Clinical trials; Cancer; Nonsense mutation; Herpes simplex virus 1 DO - http://dx.doi.org/10.1016/j.ymthe.2006.02.006 ER - TY - JOUR T1 - Occurrence of non-O157 shiga toxin-producing Escherichia coli in ready-to-eat food from supermarkets in Argentina AN - 19768294; 6513651 AB - Between June 2000 and December 2001, 500 food samples were collected from supermarkets and shops selling ready-to-eat food in Rosario, Argentina, and examined for Escherichia coli. Forty-nine E. coli isolates from food samples were further characterized for virulence genes by multiplex polymerase chain reaction (PCR) targeting the stx1, stx2, stx2e, eaeA, CNF1, CNF2, Einv, LTI, STI, and STII genes in four groups. Out of 49 E. coli isolates screened by multiplex PCR, only 10 possessed Shiga toxin genes, stx1and stx2 genes and none possessed the other genes. The Shiga toxin positive E. coli strains (STEC) were isolated from soft, cottage cheeses, chicken with sauce and vegetables mayonase. These E. coli isolates were serogrouped and belonged to O18 (two strains), O8, O57w, O79, O44, and O128; three strains were untypeable. Pulsed-field gel electrophoresis (PFGE) with XbaI generated a unique profile for each, having 10-15 bands ranging from 50 to 500kb, except that strain ARG 20 generated small bands and was partly degraded. These strains are potential foodborne pathogens and their presence in ready-to-eat food illustrates the need to keep a careful watch for the source of pathogens and then develop methods to control them. JF - Food Microbiology AU - Balague, C AU - Khan, A A AU - Fernandez, L AU - Lia Redolfi, A AU - Aquili, V AU - Voltattorni, P AU - Hofer, C AU - Ebner, G AU - Duenas, S AU - Cerniglia, CE AD - US Food and Drug Administration, NCTR, 3900 NCTR Road., Jefferson, Arkansas 72079, USA, Ashraf@nctr.fda.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 307 EP - 313 VL - 23 IS - 3 SN - 0740-0020, 0740-0020 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Vegetables KW - Food KW - Pathogens KW - Food contamination KW - Toxins KW - Virulence KW - Argentina KW - Escherichia coli KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - Sauces KW - Shiga toxin KW - J 02410:Animal Diseases KW - X 24490:Other KW - H 4000:Food and Drugs KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19768294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Occurrence+of+non-O157+shiga+toxin-producing+Escherichia+coli+in+ready-to-eat+food+from+supermarkets+in+Argentina&rft.au=Balague%2C+C%3BKhan%2C+A+A%3BFernandez%2C+L%3BLia+Redolfi%2C+A%3BAquili%2C+V%3BVoltattorni%2C+P%3BHofer%2C+C%3BEbner%2C+G%3BDuenas%2C+S%3BCerniglia%2C+CE&rft.aulast=Balague&rft.aufirst=C&rft.date=2006-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=9781321726886&rft.btitle=&rft.title=Fictions+about+the+expropriation+of+minors+in+the+francoist+regime+and+the+appropriation+of+minors+in+the+Argentine+dictatorship%3A+The+ideological+extermination+and+its+consequences+in+the+current+narrative&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Vegetables; Food; Pulsed-field gel electrophoresis; Polymerase chain reaction; Sauces; Pathogens; Shiga toxin; Food contamination; Toxins; Escherichia coli; Argentina DO - http://dx.doi.org/10.1016/j.fm.2005.03.005 ER - TY - JOUR T1 - Use of hinge joints in devices for treatment of the human locomotor system AN - 19551318; 7266398 JF - Biomedical Engineering AU - Shevtsov, VI AU - Alatov, D V AU - Burlakov, E V AD - Ilizarov Russian Scientific Center for Restorative Traumatology and Orthopedics, Federal Agency for Public Health Service and Social Development, Kurgan, Russia Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 148 EP - 151 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 40 IS - 3 SN - 0006-3398, 0006-3398 KW - Biotechnology and Bioengineering Abstracts KW - Joints KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19551318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Engineering&rft.atitle=Use+of+hinge+joints+in+devices+for+treatment+of+the+human+locomotor+system&rft.au=Shevtsov%2C+VI%3BAlatov%2C+D+V%3BBurlakov%2C+E+V&rft.aulast=Shevtsov&rft.aufirst=VI&rft.date=2006-05-01&rft.volume=40&rft.issue=3&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Biomedical+Engineering&rft.issn=00063398&rft_id=info:doi/10.1007%2Fs10527-006-0065-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Joints DO - http://dx.doi.org/10.1007/s10527-006-0065-z ER - TY - JOUR T1 - Quantification of UV-Induced Erythema and Pigmentation Using Computer-Assisted Digital Image Evaluation AN - 19460563; 7002664 AB - Photography has been used in human skin research for some time. With the advent of digital photography in recent years, its use has increased. However, the focus has now turned from documentation to actual analysis and quantification of skin color changes. The advantages of digital photography outweigh any shortcomings as long as consistent, standardized procedures are followed and quality control is implemented. We present a simple procedure to standardize images and discuss a computer-assisted digital image evaluation (CADIE) technique to quantify skin color changes following UV exposure. The CADIE approach is illustrated with examples from two different studies on UV responses in human skin. Using the Commission Internationale de l'Eclairage L*a*b* color coordinate system in combination with a personal computer and image-editing software, we analyzed digital images obtained in these two studies. We demonstrate the feasibility of using digital photography for objective evaluation of UV erythema in different racial/ethnic groups and for measuring pigmentation changes caused by repeated exposures over a period of several weeks. Our results indicate how objective assessment using CADIE can be an adjunct to visual and optical observation in clinical and scientific evaluations. JF - Photochemistry and Photobiology AU - Coelho, S G AU - Miller, SA AU - Zmudzka, B Z AU - Beer, J Z AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 651 EP - 655 PB - American Society for Photobiology VL - 82 IS - 3 SN - 0031-8655, 0031-8655 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Pigmentation KW - software KW - Erythema KW - U.V. radiation KW - Skin KW - Quality control KW - Computers KW - Photography KW - Ethnic groups KW - Color KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19460563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Quantification+of+UV-Induced+Erythema+and+Pigmentation+Using+Computer-Assisted+Digital+Image+Evaluation&rft.au=Coelho%2C+S+G%3BMiller%2C+SA%3BZmudzka%2C+B+Z%3BBeer%2C+J+Z&rft.aulast=Coelho&rft.aufirst=S&rft.date=2006-05-01&rft.volume=82&rft.issue=3&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/10.1562%2F2005-08-02-TSN-635 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0031-8655&volume=82&issue=3&page=651 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Photography; Color; Erythema; Pigmentation; Computer programs; Computers; Ethnic groups; software; U.V. radiation; Quality control DO - http://dx.doi.org/10.1562/2005-08-02-TSN-635 ER - TY - JOUR T1 - The neural basis of implicit moral attitude - An IAT study using event-related fMRI AN - 19446987; 6837131 AB - Recent models of morality have suggested the importance of affect-based automatic moral attitudes in moral reasoning. However, previous investigations of moral reasoning have frequently relied upon explicit measures that are susceptible to voluntary control. To investigate participant's automatic moral attitudes, we used a morality Implicit Association Test (IAT). Participants rated the legality of visually depicted legal and illegal behaviors of two different intensity levels (e.g., high intensity illegal = interpersonal violence; low intensity illegal = vandalism) both when the target concept (e.g., illegal) was behaviorally paired with an associated attribute (e.g., bad; congruent condition) or an unassociated attribute (e.g., good; incongruent condition). Behaviorally, an IAT effect was shown; RTs were faster in the congruent rather than incongruent conditions. At the neural level, implicit moral attitude, as indexed by increased BOLD response as a function of stimulus intensity, was associated with increased activation in the right amygdala and the ventromedial orbitofrontal cortex. In addition, performance on incongruent trials relative to congruent trials was associated with increased activity in the right ventrolateral prefrontal cortex (BA 47), left subgenual cingulate gyrus (BA 25), bilateral premotor cortex (BA 6) and the left caudate. The functional contributions of these regions in moral reasoning are discussed. JF - NeuroImage AU - Luo, Qian AU - Nakic, Marina AU - Wheatley, Thalia AU - Richell, Rebecca AU - Martin, Alex AU - Blair, RJames R AD - Unit on Affective Cognitive Neuroscience, Mood and Anxiety Program, National Institute of Mental Health, Department of Health and Human Services, 15K North Drive, Room 206, MSC 2670, Bethesda, MD 20892, USA, James.Blair@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1449 EP - 1457 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional magnetic resonance imaging KW - Cortex (cingulate) KW - Cortex (premotor) KW - Ethics KW - Amygdala KW - Aggression KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+neural+basis+of+implicit+moral+attitude+-+An+IAT+study+using+event-related+fMRI&rft.au=Luo%2C+Qian%3BNakic%2C+Marina%3BWheatley%2C+Thalia%3BRichell%2C+Rebecca%3BMartin%2C+Alex%3BBlair%2C+RJames+R&rft.aulast=Luo&rft.aufirst=Qian&rft.date=2006-05-01&rft.volume=30&rft.issue=4&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethics; Cortex (prefrontal); Cortex (premotor); Cortex (cingulate); Amygdala; Aggression; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2005.11.005 ER - TY - JOUR T1 - Computational modeling of biologically active molecules using NMR spectra AN - 17177986; 6855696 AB - The molecular structure and NMR chemical shift information of a compound can be combined to form powerful models of biological activity. NMR spectral data and structure information can be combined on a structural template analogous to 3D-QSAR methodology or orientation independently in spectral space. Surprisingly, quantitative spectrometric data-activity relationship (QSDAR) models built on structure templates are inferior to multi-dimensional QSDAR models built in spectral space. 3D-QSDAR modeling could be useful for estimating chemical toxicity, risk assessment of environmental contaminants and drug lead-compound identifications. JF - Drug Discovery Today AU - Beger, R D AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA, richard.beger@fda.hhs.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 429 EP - 435 PB - Elsevier Ltd VL - 11 IS - 9-10 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Risk assessment KW - Molecular modelling KW - Drug discovery KW - N.M.R. KW - Toxicity KW - Contaminants KW - Computer applications KW - W3 33080:Bioinformatics and computer applications KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17177986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Computational+modeling+of+biologically+active+molecules+using+NMR+spectra&rft.au=Beger%2C+R+D&rft.aulast=Beger&rft.aufirst=R&rft.date=2006-05-01&rft.volume=11&rft.issue=9-10&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2006.03.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Drug discovery; Molecular modelling; N.M.R.; Toxicity; Computer applications; Contaminants DO - http://dx.doi.org/10.1016/j.drudis.2006.03.014 ER - TY - JOUR T1 - Streamlined sample preparation procedure for determination of perchlorate anion in foods by ion chromatography-tandem mass spectrometry AN - 17173637; 6836325 AB - A rapid, sensitive, and specific method was developed for the determination of perchlorate anion in foods. The foods included high moisture fruits and vegetables, low moisture foods (e.g. wheat flour and corn meal), and infant foods. Improvements to existing procedures were made in sample preparation that reduced sample test portion size from 100 to 5 or 10 g, extraction solvent volume from 150 to 20-40 ml, and replaced blending extraction-vacuum filtration and their associated large glassware with a simple shakeout-centrifugation in a small conical tube. Procedures common to all matrices involved: extraction, centrifugation, graphitized carbon solid phase extraction (SPE) cleanup, and ion chromatography-tandem mass spectrometry (IC-MS/MS) analysis. A Waters IC-Pak Anion HR column (4.6 mm x 75 mm) was eluted with 100 mM ammonium acetate in 50:50 (v/v) acetonitrile/water mobile phase at a rate of 0.35 ml/min. A triple stage quadrupole mass spectrometer, equipped with electrospray ionization (ESI) in the negative ion mode, was used to detect perchlorate anion. An super(18)O sub(4)- labeled perchlorate anion internal standard was used to correct for any matrix effects. The method limit of quantitation (LOQ) was: 1.0 mu g/kg in fruits, vegetables, and infant foods; 3.0 mu g/kg in dry products. Fortified test portions gave 80-120% recoveries. Determination of incurred perchlorate anion residues agreed well with results for comparable commodities or products analyzed by published methods. JF - Analytica Chimica Acta AU - Krynitsky, Alexander J AU - Niemann, Richard A AU - Williams, Anthony D AU - Hopper, Marvin L AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, United States, Alex.Krynitsky@fda.hhs.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 94 EP - 99 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 567 IS - 1 SN - 0003-2670, 0003-2670 KW - Wheat KW - Toxicology Abstracts KW - Perchlorate anion KW - Foods KW - SPE KW - IC-MS/MS KW - Fruits KW - Vegetables KW - Anions KW - Food KW - Ammonium acetate KW - Mass spectroscopy KW - Triticum aestivum KW - Centrifugation KW - Filtration KW - Carbon KW - Acetonitrile KW - Ionization KW - Flour KW - X 24120:Food, additives & contaminants KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17173637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Streamlined+sample+preparation+procedure+for+determination+of+perchlorate+anion+in+foods+by+ion+chromatography-tandem+mass+spectrometry&rft.au=Krynitsky%2C+Alexander+J%3BNiemann%2C+Richard+A%3BWilliams%2C+Anthony+D%3BHopper%2C+Marvin+L&rft.aulast=Krynitsky&rft.aufirst=Alexander&rft.date=2006-05-01&rft.volume=567&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2006.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Centrifugation; Fruits; Filtration; Vegetables; Carbon; Anions; Food; Acetonitrile; Ammonium acetate; Ionization; Flour; Mass spectroscopy; Triticum aestivum DO - http://dx.doi.org/10.1016/j.aca.2006.01.005 ER - TY - JOUR T1 - Determination of methylmercury and estimation of total mercury in seafood using high performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectrometry (ICP-MS): Method development and validation AN - 17166159; 6839025 AB - A method was developed for determination of methylmercury and estimation of total mercury in seafood. Mercury (Hg) compounds were extracted from 0.5 g edible seafood or 0.2 g lyophilized reference material by adding 50 ml aqueous 1% w/v l-cysteine times HCl times H sub(2)O and heating 120 min at 60 degree C in glass vials. Hg compounds in 50 mu l of filtered extract were separated by reversed- phase high performance liquid chromatography using a C-18 column and aqueous 0.1% w/v l-cysteine times HCl times H sub(2)O + 0.1% w/v l-cysteine mobile phase at room temperature and were detected by inductively coupled plasma-mass spectrometry at mass-to-charge ratio 202. Total Hg was calculated as the mathematical sum of methyl and inorganic Hg determined in extracts. For seafoods containing 0.055-2.78 mg kg super(-1) methylmercury and 0.014-0.137 mg kg super(-1) inorganic Hg, precision of analyses was <=5% relative standard deviation (R.S.D.) for methylmercury and <=9% R.S.D. for inorganic Hg. Recovery of added analyte was 94% for methylmercury and 98% for inorganic Hg. Methyl and total Hg results for reference materials agreed with certified values. Limits of quantitation were 0.007 mg kg super(-1) methylmercury and 0.005 mg kg super(-1) inorganic Hg in edible seafood and 0.017 mg kg super(-1) methylmercury and 0.012 mg kg super(-1) inorganic Hg in lyophilized reference materials. Evaluation of analyte stability demonstrated that l-cysteine both stabilized and de-alkylated methylmercury, depending on holding time and cysteine concentration. Polypropylene adversely affected methylmercury stability. Total Hg results determined by this method were equivalent to results determined independently by cold vapour-atomic absorption spectrometry. Methylmercury was the predominant form of Hg in finfish. Ratios of methylmercury/total Hg determined by this method were 93-98% for finfish and 38-48% for mollusks. JF - Analytica Chimica Acta AU - Hight, Susan C AU - Cheng, John AD - Elemental Research Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740- 3835, USA, susan.hight@fda.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 160 EP - 172 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com] VL - 567 IS - 2 SN - 0003-2670, 0003-2670 KW - Mollusks KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Methylmercury KW - Total mercury KW - Seafood KW - Inductively coupled plasma-mass spectrometry KW - High performance liquid chromatography KW - High-performance liquid chromatography KW - Temperature effects KW - HPLC KW - Methyl mercury KW - Quality assurance KW - polypropylene KW - Spectrometry KW - Public health KW - Pisces KW - Absorption spectroscopy KW - Standard deviation KW - Cysteine KW - Detection KW - Dimethylmercury KW - Mercury KW - Marine molluscs KW - Mollusca KW - X 24120:Food, additives & contaminants KW - X 24222:Analytical procedures KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17166159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Determination+of+methylmercury+and+estimation+of+total+mercury+in+seafood+using+high+performance+liquid+chromatography+%28HPLC%29+and+inductively+coupled+plasma-mass+spectrometry+%28ICP-MS%29%3A+Method+development+and+validation&rft.au=Hight%2C+Susan+C%3BCheng%2C+John&rft.aulast=Hight&rft.aufirst=Susan&rft.date=2006-05-01&rft.volume=567&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2006.03.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - HPLC; Methyl mercury; Absorption spectroscopy; Quality assurance; Detection; Marine molluscs; Seafood; Public health; Temperature effects; High-performance liquid chromatography; Standard deviation; Cysteine; Dimethylmercury; Mercury; polypropylene; Spectrometry; Pisces; Mollusca DO - http://dx.doi.org/10.1016/j.aca.2006.03.048 ER - TY - JOUR T1 - Anthrax Lethal Toxin Has Direct and Potent Inhibitory Effects on B Cell Proliferation and Immunoglobulin Production AN - 17165540; 6811398 AB - Protective host immune responses to anthrax infection in humans and animal models are characterized by the development of neutralizing Abs against the receptor-binding anthrax protective Ag (PA), which, together with the lethal factor (LF) protease, composes anthrax lethal toxin (LT). We now report that B cells, in turn, are targets for LT. Anthrax PA directly binds primary B cells, resulting in the LF-dependent cleavage of the MAPK kinases (MAPKKs) and disrupted signaling to downstream MAPK targets. Although not directly lethal to B cells, anthrax LT treatment causes severe B cell dysfunction, greatly reducing proliferative responses to IL-4-, anti-IgM-, and/or anti-CD40 stimulation. Moreover, B cells treated with anthrax LT in vitro or isolated from mice treated with anthrax LT in vivo have a markedly diminished capacity to proliferate and produce IgM in response to TLR-2 and TLR-4 ligands. The suppressive effects of anthrax LT on B cell function occur at picomolar concentrations in vitro and at sublethal doses in vivo. These results indicate that anthrax LT directly inhibits the function of B cells in vitro and in vivo, revealing a potential mechanism through which the pathogen could bypass protective immune responses. JF - Journal of Immunology AU - Fang, Hui AU - Xu, Lixin AU - Chen, Trina Y AU - Cyr, Julianne M AU - Frucht, David M AD - Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 6155 EP - 6161 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 10 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anthrax lethal toxin KW - MAP kinase KW - Lymphocytes B KW - Lethal factor KW - TLR2 protein KW - Animal models KW - Pathogens KW - Bacillus anthracis KW - Inhibition KW - Infection KW - Toxins KW - Antibodies KW - Anthrax KW - Proteinase KW - Immune response KW - Cell proliferation KW - Toll-like receptors KW - Immunoglobulin M KW - Immunoglobulins KW - Signal transduction KW - X 24370:Natural Toxins KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17165540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Anthrax+Lethal+Toxin+Has+Direct+and+Potent+Inhibitory+Effects+on+B+Cell+Proliferation+and+Immunoglobulin+Production&rft.au=Fang%2C+Hui%3BXu%2C+Lixin%3BChen%2C+Trina+Y%3BCyr%2C+Julianne+M%3BFrucht%2C+David+M&rft.aulast=Fang&rft.aufirst=Hui&rft.date=2006-05-01&rft.volume=176&rft.issue=10&rft.spage=6155&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; MAP kinase; Lymphocytes B; Lethal factor; TLR2 protein; Animal models; Pathogens; Infection; Inhibition; Toxins; Antibodies; Anthrax; Proteinase; Immune response; Cell proliferation; Immunoglobulin M; Toll-like receptors; Signal transduction; Immunoglobulins; Bacillus anthracis ER - TY - JOUR T1 - Rapid, Sensitive, and Specific Lateral-Flow Immunochromatographic Device To Measure Anti-Anthrax Protective Antigen Immunoglobulin G in Serum and Whole Blood AN - 17152672; 6815323 AB - Evidence from animals suggests that anti-anthrax protective antigen (PA) immunoglobulin G (IgG) from vaccination with anthrax vaccine adsorbed (AVA) is protective against Bacillus anthracis infection. Measurement of anti-PA IgG in human sera can be performed using either enzyme-linked immunosorbent assay or fluorescent covalent microsphere immunoassay (ELISA). Both these methods are laboratory based. We describe the development of a rapid lateral-flow immunochromatographic assay (LFIA) test kit for the measurement of anti-PA IgG in serum or whole-blood samples (30- mu l samples) using colloidal gold nanoparticles as the detection reagent and an internal control. Using sera from 19 anthrax AVA vaccinees (anti-PA IgG range, 2.4 to 340 mu g/ml) and 10 controls and PA-supplemented whole-blood samples, we demonstrated that the LFIA had a sensitivity of approximately 3 mu g/ml anti-PA IgG in serum and similar to 14 mu g/ml anti-PA IgG in whole blood. Preabsorption of sera with PA yielded negative anti-PA LFIAs. The diagnostic sensitivity and specificity of the assay were 100% using ELISA-measured anti-PA IgG as the standard. This kit has utility in determining anti-PA antibody reactivity in the sera of individuals vaccinated with AVA or individuals with clinical anthrax. JF - Clinical and Vaccine Immunology AU - Biagini, Raymond E AU - Sammons, Deborah L AU - Smith, Jerome P AU - MacKenzie, Barbara A AU - Striley, Cynthia AF AU - Snawder, John E AU - Robertson, Shirley A AU - Quinn, Conrad P AD - Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, Ohio. Microbial Pathogenesis and Immune Response (MPIR) Laboratory, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 541 EP - 546 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 5 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Chromatography KW - protective antigen KW - Bacillus anthracis KW - Infection KW - Vaccination KW - Blood KW - Serum KW - microspheres KW - Immunoglobulin G KW - Gold KW - Anthrax KW - Vaccines KW - Immunoassays KW - nanoparticles KW - J 02831:Techniques and reagents KW - F 06704:Immunoassays UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17152672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Rapid%2C+Sensitive%2C+and+Specific+Lateral-Flow+Immunochromatographic+Device+To+Measure+Anti-Anthrax+Protective+Antigen+Immunoglobulin+G+in+Serum+and+Whole+Blood&rft.au=Biagini%2C+Raymond+E%3BSammons%2C+Deborah+L%3BSmith%2C+Jerome+P%3BMacKenzie%2C+Barbara+A%3BStriley%2C+Cynthia+AF%3BSnawder%2C+John+E%3BRobertson%2C+Shirley+A%3BQuinn%2C+Conrad+P&rft.aulast=Biagini&rft.aufirst=Raymond&rft.date=2006-05-01&rft.volume=13&rft.issue=5&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Chromatography; protective antigen; Infection; Vaccination; Blood; Serum; Immunoglobulin G; microspheres; Anthrax; Gold; Vaccines; nanoparticles; Immunoassays; Bacillus anthracis ER - TY - JOUR T1 - Campylobacter jejuni Induces Maturation and Cytokine Production in Human Dendritic Cells AN - 17147649; 6810435 AB - Campylobacter jejuni is a leading bacterial cause of human diarrheal disease in both developed and developing nations. Colonic mucosal invasion and the resulting host inflammatory responses are thought to be the key contributing factors to the dysenteric form of this disease. Dendritic cells (DCs) play an important role in both the innate and adaptive immune responses to microbial infection. In this study, the interaction between human monocyte-derived dendritic cells and C. jejuni was studied. We found that C. jejuni was readily internalized by DCs over a 2-h period. However, after a prolonged infection period (24 or 48 h) with C. jejuni, only a few viable bacteria remained intracellularly. Minimal cytotoxicity of C. jejuni to dendritic cells was observed. C. jejuni induced the maturation of dendritic cells over 24 h, as indicated by up-regulation of cell surface marker proteins CD40, CD80, and CD86. In addition, Campylobacter-infected DCs triggered activation of NF- Kappa B and significantly stimulated production of interleukin-1 beta (IL-1 beta ), IL-6, IL-8, IL-10, IL-12, gamma interferon, and tumor necrosis factor alpha (TNF- alpha ) compared to uninfected DCs. Active bacterial invasion of DCs was not necessary for the induction of these cytokines, as heat-killed C. jejuni stimulated similar levels of cytokine production as live bacteria. Purified lipooligosaccharide of C. jejuni appears to be the major stimulant for the increased production of cytokines by DCs. Taken together, these data indicate that during infection, Campylobacter triggers an innate inflammatory response through increased production of IL-1 beta , IL-6, IL-8, and TNF- alpha and initiates a Th1-polarized adaptive immune response as predicted from the high level of production of IL-12. JF - Infection and Immunity AU - Hu, Lan AU - Bray, Mechelle D AU - Osorio, Manuel AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Building 29/420, HFM440, Bethesda, Maryland 20892 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 2697 EP - 2705 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 5 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Diarrhea KW - CD86 antigen KW - Interleukins KW - Inflammation KW - NF- Kappa B protein KW - Dendritic cells KW - Campylobacter jejuni KW - CD80 antigen KW - Cytokines KW - Tumor necrosis factor- alpha KW - Monocytes KW - CD40 antigen KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Campylobacter+jejuni+Induces+Maturation+and+Cytokine+Production+in+Human+Dendritic+Cells&rft.au=Hu%2C+Lan%3BBray%2C+Mechelle+D%3BOsorio%2C+Manuel%3BKopecko%2C+Dennis+J&rft.aulast=Hu&rft.aufirst=Lan&rft.date=2006-05-01&rft.volume=74&rft.issue=5&rft.spage=2697&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Dendritic cells; Diarrhea; CD86 antigen; Interleukins; Cytokines; CD80 antigen; Monocytes; Tumor necrosis factor- alpha; CD40 antigen; NF- Kappa B protein; Inflammation; Campylobacter jejuni ER - TY - JOUR T1 - Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo AN - 17146723; 6810544 AB - Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis. JF - Journal of Bacteriology AU - Dheenadhayalan, Veerabadran AU - Delogu, Giovanni AU - Sanguinetti, Maurizio AU - Fadda, Giovanni AU - Brennan, Michael J AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland. Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3721 EP - 3725 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 10 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Gene expression KW - Macrophages KW - Growth conditions KW - Immunopathogenesis KW - Tuberculosis KW - Mycobacterium tuberculosis KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17146723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Variable+Expression+Patterns+of+Mycobacterium+tuberculosis+PE_PGRS+Genes%3A+Evidence+that+PE_PGRS16+and+PE_PGRS26+Are+Inversely+Regulated+In+Vivo&rft.au=Dheenadhayalan%2C+Veerabadran%3BDelogu%2C+Giovanni%3BSanguinetti%2C+Maurizio%3BFadda%2C+Giovanni%3BBrennan%2C+Michael+J&rft.aulast=Dheenadhayalan&rft.aufirst=Veerabadran&rft.date=2006-05-01&rft.volume=188&rft.issue=10&rft.spage=3721&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Gene expression; Growth conditions; Immunopathogenesis; Tuberculosis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture AN - 17118671; 6753284 AB - Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is used as a general pediatric anesthetic. Recent data suggest that anesthetic drugs may cause neurodegeneration during development. The purpose of this study was to determine the robustness of ketamine-induced developmental neurotoxicity using rhesus monkey frontal cortical cultures and also to determine if dysregulation of NMDA receptor subunits promotes ketamine-induced cell death. Frontal cortical cells collected from the neonatal monkey were incubated for 24 h with 1, 10, or 20 mu M ketamine alone or with ketamine plus either NR1 antisense oligonucleotides or the nuclear factor kB translocation inhibitor, SN-50. Ketamine caused a marked reduction in the neuronal marker polysialic acid neural cell adhesion molecule and mitochondrial metabolism, as well as an increase in DNA fragmentation and release of lactate dehydrogenase. Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro. JF - Toxicological Sciences AU - Wang, Cheng AU - Sadovova, Natalya AU - Hotchkiss, Charlotte AU - Fu, Xin AU - Scallet, Andrew C AU - Patterson, Tucker A AU - Hanig, Joseph AU - Paule, Merle G AU - Slikker, William Jr AD - Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 192 EP - 201 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 1 SN - 1096-6080, 1096-6080 KW - Rhesus macaque KW - Rhesus monkey KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - N-Methyl-D-aspartic acid receptors KW - Lactate dehydrogenase KW - Mitochondria KW - Anesthetics KW - Cell culture KW - Neuroprotection KW - Neurodegeneration KW - NF- Kappa B protein KW - Neural cell adhesion molecule KW - Nuclear transport KW - Antisense oligonucleotides KW - DNA fragmentation KW - Cortex KW - Ketamine KW - Macaca mulatta KW - polysialic acid KW - Pediatrics KW - Drug development KW - Glutamic acid receptors KW - L-Lactate dehydrogenase KW - Cell death KW - Neurotoxicity KW - Neonates KW - Metabolism KW - X 24115:Pathology KW - N3 11105:Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17118671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Blockade+of+N-Methyl-D-Aspartate+Receptors+by+Ketamine+Produces+Loss+of+Postnatal+Day+3+Monkey+Frontal+Cortical+Neurons+in+Culture&rft.au=Wang%2C+Cheng%3BSadovova%2C+Natalya%3BHotchkiss%2C+Charlotte%3BFu%2C+Xin%3BScallet%2C+Andrew+C%3BPatterson%2C+Tucker+A%3BHanig%2C+Joseph%3BPaule%2C+Merle+G%3BSlikker%2C+William+Jr&rft.aulast=Wang&rft.aufirst=Cheng&rft.date=2006-05-01&rft.volume=91&rft.issue=1&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - N-Methyl-D-aspartic acid receptors; Lactate dehydrogenase; Pediatrics; Anesthetics; Mitochondria; Drug development; Neuroprotection; Cell culture; Glutamic acid receptors; Neurodegeneration; L-Lactate dehydrogenase; NF- Kappa B protein; Neural cell adhesion molecule; DNA fragmentation; Antisense oligonucleotides; Nuclear transport; Cell death; Cortex; Neurotoxicity; Ketamine; Neonates; polysialic acid; Metabolism; Macaca mulatta ER - TY - CPAPER T1 - Nanomaterials in the Environment: Analytical Measurement Issues T2 - Tenth International Symposium on Biological and Environmental Reference Materials (BERM 2006) AN - 40036038; 4220659 DE: JF - Tenth International Symposium on Biological and Environmental Reference Materials (BERM 2006) AU - Hoover, Mark D Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40036038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Tenth+International+Symposium+on+Biological+and+Environmental+Reference+Materials+%28BERM+2006%29&rft.atitle=Nanomaterials+in+the+Environment%3A+Analytical+Measurement+Issues&rft.au=Hoover%2C+Mark+D&rft.aulast=Hoover&rft.aufirst=Mark&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Tenth+International+Symposium+on+Biological+and+Environmental+Reference+Materials+%28BERM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.csc.noaa.gov/berm/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Harnessing Nanotechnology for Ocular Drug Delivery T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40033081; 4196757 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Lee, V Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Drug delivery KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40033081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Harnessing+Nanotechnology+for+Ocular+Drug+Delivery&rft.au=Lee%2C+V&rft.aulast=Lee&rft.aufirst=V&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Particulate Reference Materials for Evaluating Quantitative Analytical Methods for Beryllium T2 - Tenth International Symposium on Biological and Environmental Reference Materials (BERM 2006) AN - 39956970; 4220756 JF - Tenth International Symposium on Biological and Environmental Reference Materials (BERM 2006) AU - Stefaniak, Aleksandr B AU - Brink, Christopher A AU - Dickerson, Robert M AU - Day, Gregory A AU - Brisson, Michael J AU - Scripsick, Ronald C AU - Hoover, Mark D Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Particulates KW - Beryllium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Tenth+International+Symposium+on+Biological+and+Environmental+Reference+Materials+%28BERM+2006%29&rft.atitle=Particulate+Reference+Materials+for+Evaluating+Quantitative+Analytical+Methods+for+Beryllium&rft.au=Stefaniak%2C+Aleksandr+B%3BBrink%2C+Christopher+A%3BDickerson%2C+Robert+M%3BDay%2C+Gregory+A%3BBrisson%2C+Michael+J%3BScripsick%2C+Ronald+C%3BHoover%2C+Mark+D&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Tenth+International+Symposium+on+Biological+and+Environmental+Reference+Materials+%28BERM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.csc.noaa.gov/berm/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence that PE-PGRS Proteins of Mycobacterium tuberculosis may Influence Progression of the Disease T2 - Second International Conference on TB Vaccines for the World (TBV 2006) AN - 39949828; 4165684 JF - Second International Conference on TB Vaccines for the World (TBV 2006) AU - Brennan, Mike Y1 - 2006/04/19/ PY - 2006 DA - 2006 Apr 19 KW - Tuberculosis KW - Mycobacterium tuberculosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.atitle=Evidence+that+PE-PGRS+Proteins+of+Mycobacterium+tuberculosis+may+Influence+Progression+of+the+Disease&rft.au=Brennan%2C+Mike&rft.aulast=Brennan&rft.aufirst=Mike&rft.date=2006-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2006/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pre-Clinical Assessment of Vaccine-Induced Protection using different M. tuberculosis Challenge Strains T2 - Second International Conference on TB Vaccines for the World (TBV 2006) AN - 39865281; 4165690 JF - Second International Conference on TB Vaccines for the World (TBV 2006) AU - Morris, Sheldon L Y1 - 2006/04/19/ PY - 2006 DA - 2006 Apr 19 KW - Vaccines KW - Tuberculosis KW - Strains KW - Mycobacterium tuberculosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.atitle=The+Pre-Clinical+Assessment+of+Vaccine-Induced+Protection+using+different+M.+tuberculosis+Challenge+Strains&rft.au=Morris%2C+Sheldon+L&rft.aulast=Morris&rft.aufirst=Sheldon&rft.date=2006-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2006/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy. AN - 67992599; 16709016 AB - Targeting cell surface receptors with cytotoxins or immunotoxins provides a unique opportunity for brain tumor therapy. The authors have discovered that receptors for two cytokines, interleukin (IL)-4 and IL-13, are overexpressed on tumor biopsy samples and on cell lines derived from a variety of human tumors, including brain tumors. These investigators have demonstrated that the structure of these cytokine receptors on tumor cells is different from that found on normal immune cells. In human solid tumor cells, IL-4 binds to two chains (IL-4Ra and IL-13Ra1), whereas IL- 13 binds to three chains in many solid tumor cells, including glioma cells (to IL-4Ra, IL-13Ra1, and IL-13Ra2). To target IL-4Rs and IL-13Rs, the authors generated two recombinant fusion cytotoxins composed of IL-4 or IL-13 and a mutated form of pseudomonas exotoxin (PE), which for simplicity are called IL4-PE and IL13-PE in this paper. These chimeric cytotoxins are highly toxic in vitro to human tumor cell lines and primary cell cultures, including glioma cells, and in vivo to animal models of human tumors, including gliomas. In contrast, normal cells, including immune, endothelial, and brain cells, are spared from their cytotoxic effects. Based on numerous preclinical studies, IL13-PE (also known as IL13-PE38QQR or cintredekin besudotox) has been tested in four Phase I/II clinical trials. The agent IL13-PE was administered intracranially by using convection-enhanced delivery (CED). The drug was delivered through catheters placed either directly into the tumor bed or in the peritumoral region after resection of the lesion. The CED of IL13-PE was fairly well tolerated, with a reasonable benefit/risk profile for treatment of patients with glioma. Based on Phase I/II clinical trials, the Phase III Randomized Evaluation of CED of IL13-PE Compared to Gliadel Wafer with Survival Endpoint Trial (also known as the PRECISE Trial) in patients with initial recurrence of glioblastoma multiforme has recently been completed. Patients are being monitored for safety of the agents, duration of overall survival, and quality of life. JF - Neurosurgical focus AU - Shimamura, Takeshi AU - Husain, Syed R AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2006/04/15/ PY - 2006 DA - 2006 Apr 15 SP - 1 VL - 20 IS - 4 KW - Antineoplastic Agents KW - 0 KW - Exotoxins KW - Immunotoxins KW - Interleukin-13 KW - Receptors, Interleukin KW - Recombinant Fusion Proteins KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Humans KW - Receptors, Interleukin -- drug effects KW - Recombinant Fusion Proteins -- toxicity KW - Recombinant Fusion Proteins -- administration & dosage KW - Receptors, Interleukin -- immunology KW - Recombinant Fusion Proteins -- chemical synthesis KW - Interleukin-13 -- chemistry KW - Exotoxins -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Immunotoxins -- toxicity KW - Immunotoxins -- administration & dosage KW - Exotoxins -- chemical synthesis KW - Immunotoxins -- chemistry KW - Brain Neoplasms -- drug therapy KW - Glioma -- drug therapy KW - Antineoplastic Agents -- toxicity KW - Antineoplastic Agents -- chemical synthesis KW - Exotoxins -- toxicity KW - Interleukin-4 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67992599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgical+focus&rft.atitle=The+IL-4+and+IL-13+pseudomonas+exotoxins%3A+new+hope+for+brain+tumor+therapy.&rft.au=Shimamura%2C+Takeshi%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2006-04-15&rft.volume=20&rft.issue=4&rft.spage=E11&rft.isbn=&rft.btitle=&rft.title=Neurosurgical+focus&rft.issn=1092-0684&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - International Conference on Harmonisation; Guidance on S8 Immunotoxicity Studies for Human Pharmaceuticals; availability. Notice. AN - 67858887; 16612859 AB - The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "S8 Immunotoxicity Studies for Human Pharmaceuticals." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance provides recommendations on nonclinical testing approaches to identify compounds that have the potential to be immunotoxic and guidance on a weight-of-evidence decision making approach for immunotoxicity testing. The guidance is intended to provide recommendations on nonclinical testing for immunotoxicity induced by human pharmaceuticals. The guidance applies to unintended immunosuppression and immunoenhancement, excluding allergenicity or drug-specific autoimmunity. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2006/04/13/ PY - 2006 DA - 2006 Apr 13 SP - 19193 EP - 19194 VL - 71 IS - 71 SN - 0097-6326, 0097-6326 KW - Immunotoxins KW - 0 KW - Health technology assessment KW - United States KW - Immune System Diseases -- chemically induced KW - United States Food and Drug Administration KW - European Union KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - In Vitro Techniques KW - Immunotoxins -- adverse effects KW - Chemistry, Pharmaceutical -- standards KW - Europe KW - Congresses as Topic KW - Japan KW - Cytotoxicity Tests, Immunologic -- standards KW - International Cooperation KW - Guidelines as Topic KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67858887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=International+Conference+on+Harmonisation%3B+Guidance+on+S8+Immunotoxicity+Studies+for+Human+Pharmaceuticals%3B+availability.+Notice.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2006-04-13&rft.volume=71&rft.issue=71&rft.spage=19193&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulations on health/functional foods in Korea AN - 17075225; 6702906 AB - The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these products to be marketed in measured doses, such as in pills, tablets, capsules, and liquids. HFFs are of two types: generic and product- specific. There are 37 ingredients listed in the act for generic HFFs, and if an HFF contains a new active ingredient that is not included in the generic 37 products, it is considered a product-specific HFF. The standardization, safety, and efficacy of a new active ingredient are reviewed by the Korean Food and Drug Administration in order to receive approval as a product-specific HFF. Conforming with international standards and protecting public health requires constant upgrading of the Health/Functional Food Act. JF - Toxicology AU - Kim, Ji Yeon AU - Kim, Dai Byung AU - Lee, Hyong Joo AD - Nutrition and Functional Food Headquarters, Korea Food and Drug Administration, Seoul 122-704, South Korea, leehyjo@snu.ac.kr Y1 - 2006/04/03/ PY - 2006 DA - 2006 Apr 03 SP - 112 EP - 118 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 221 IS - 1 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Health/Functional Food Act KW - Product-specific HFF KW - Standardization KW - Safety KW - Efficacy KW - Diets KW - International standards KW - Food KW - Dietary supplements KW - Reviews KW - Tablets KW - Government policy KW - Nutrients KW - Korea, Rep. KW - Public health KW - X 24230:Legislation & recommended standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17075225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Regulations+on+health%2Ffunctional+foods+in+Korea&rft.au=Kim%2C+Ji+Yeon%3BKim%2C+Dai+Byung%3BLee%2C+Hyong+Joo&rft.aulast=Kim&rft.aufirst=Ji&rft.date=2006-04-03&rft.volume=221&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2006.01.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Standardization; International standards; Reviews; Dietary supplements; Food; Tablets; Government policy; Nutrients; Public health; Korea, Rep. DO - http://dx.doi.org/10.1016/j.tox.2006.01.016 ER - TY - JOUR T1 - FDA perspectives on health claims for food labels AN - 17071712; 6702899 AB - The U.S. Food and Drug Administration's regulatory authority over health claims was clarified in 1990 legislation known as the Nutrition Labeling and Education Act (NLEA). This law established mandatory nutrition labeling for most foods and placed restrictions on the use of food label claims characterizing the levels or health benefits of nutrients in foods. NLEA set a high threshold for the scientific standard under which the U.S. Food and Drug Administration (FDA) may authorize health claims, this standard is known as the significant scientific agreement (SSA) standard. Subsequent legislation known as the Food and Drug Administration Modernization Act (FDAMA) provided an alternative to FDA review of the health claim where an U.S. government scientific body other than FDA concluded that there is SSA for a substance/disease relationship. Courts have since extended the scope of health claims to include qualified health claims (QHC) that are health claims not substantiated on evidence that meets the level of SSA standard, but include a qualifying statement intended to convey to the consumer the level of evidence for the claim. FDA has responded by developing an evidence-based ranking system for scientific data to determine the level of evidence substantiating a health claim. The following is an overview of FDA's regulations and evidence-based method for evaluating health claims. JF - Toxicology AU - Rowlands, JCraig AU - Hoadley, James E AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA, JCRowlands@Dow.com Y1 - 2006/04/03/ PY - 2006 DA - 2006 Apr 03 SP - 35 EP - 43 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 221 IS - 1 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Nutrition Labeling Education Act KW - Health claim KW - Nutrition Facts Panel KW - Nutrient content claim KW - Evidence-based ranking system KW - USA KW - Reviews KW - Nutrients KW - Consumers KW - Nutrition KW - Legislation KW - Public health KW - X 24230:Legislation & recommended standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17071712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=FDA+perspectives+on+health+claims+for+food+labels&rft.au=Rowlands%2C+JCraig%3BHoadley%2C+James+E&rft.aulast=Rowlands&rft.aufirst=JCraig&rft.date=2006-04-03&rft.volume=221&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2005.10.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Reviews; Consumers; Nutrients; Nutrition; Legislation; Public health; USA DO - http://dx.doi.org/10.1016/j.tox.2005.10.023 ER - TY - JOUR T1 - Exhaled nitric oxide measurement in workers in a microwave popcorn production plant. AN - 68006463; 16722189 AB - Airways obstruction in microwave-popcorn workers has been attributed to inhalation of flavoring agents. Two former workers at a microwave-popcorn plant were found by lung biopsy to have bronchiolitis obliterans. The study's aim was to determine whether exhaled nitric oxide (FENO) levels were associated with exposure levels, respiratory symptoms, or airways obstruction. A questionnaire, spirometry, and FENO measurements were completed by 135 workers. The FENO levels of workers with high flavoring exposures (n = 107) were compared with those of workers with low exposures (n = 28) and healthy external controls (n = 31). FENO levels were significantly lower in the high-exposure group (p < 0.05). There is no indication that FENO is useful as a marker of lung injury in a flavoring-exposed worker population with a substantial lung disease burden, but the finding of low FENO in the high-exposure group should not be dismissed. JF - International journal of occupational and environmental health AU - Akpinar-Elci, Muge AU - Stemple, Kimberly J AU - Elci, Omur Cinar AU - Dweik, Raed A AU - Kreiss, Kathleen AU - Enright, Paul L AD - CDC/NIOSH Division of Respiratory Diseases Studies, Morgantown, West Virginia 26505, USA. melci@cdc.gov PY - 2006 SP - 106 EP - 110 VL - 12 IS - 2 SN - 1077-3525, 1077-3525 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Flavoring Agents KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Humans KW - Aged KW - Air Pollutants, Occupational -- toxicity KW - Bronchiolitis Obliterans -- etiology KW - Flavoring Agents -- toxicity KW - Microwaves KW - Adult KW - Occupational Exposure -- adverse effects KW - Biomarkers -- metabolism KW - Middle Aged KW - Adolescent KW - Breath Tests KW - Female KW - Male KW - Nitric Oxide -- analysis KW - Airway Obstruction -- etiology KW - Zea mays KW - Food Handling KW - Nitric Oxide -- metabolism KW - Airway Obstruction -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68006463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Exhaled+nitric+oxide+measurement+in+workers+in+a+microwave+popcorn+production+plant.&rft.au=Akpinar-Elci%2C+Muge%3BStemple%2C+Kimberly+J%3BElci%2C+Omur+Cinar%3BDweik%2C+Raed+A%3BKreiss%2C+Kathleen%3BEnright%2C+Paul+L&rft.aulast=Akpinar-Elci&rft.aufirst=Muge&rft.date=2006-04-01&rft.volume=12&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suggestions for preventing musculoskeletal disorders in home healthcare workers. Part 2: lift and transfer assistance for non-weight-bearing home care patients. AN - 67939904; 16680053 AB - Home healthcare (HHC) is one of the fastest-growing professions, currently employing more than 1 million workers in the United States. Unfortunately, these workers sustain an exceptionally high rate of musculoskeletal disorders. This is the second article in a two-part series providing information and suggestions for preventing overexertion that can lead to such disorders. JF - Home healthcare nurse AU - Parsons, Kelley S AU - Galinsky, Traci L AU - Waters, Thomas AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. kparsons@cdc.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 227 EP - 33; quiz 234-5 VL - 24 IS - 4 SN - 0884-741X, 0884-741X KW - Nursing KW - Occupational Health KW - Human Engineering KW - Equipment Design KW - Beds KW - Humans KW - Activities of Daily Living KW - Weight-Bearing KW - Musculoskeletal Diseases -- etiology KW - Musculoskeletal Diseases -- prevention & control KW - Occupational Diseases -- prevention & control KW - Home Care Services KW - Occupational Diseases -- etiology KW - Transportation of Patients -- methods KW - Lifting -- adverse effects KW - Community Health Nursing -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67939904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+healthcare+nurse&rft.atitle=Suggestions+for+preventing+musculoskeletal+disorders+in+home+healthcare+workers.+Part+2%3A+lift+and+transfer+assistance+for+non-weight-bearing+home+care+patients.&rft.au=Parsons%2C+Kelley+S%3BGalinsky%2C+Traci+L%3BWaters%2C+Thomas&rft.aulast=Parsons&rft.aufirst=Kelley&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Home+healthcare+nurse&rft.issn=0884741X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a technique for serial bilateral renal biopsy in steers. AN - 67912142; 16639940 AB - A biopsy procedure was developed to provide serial kidney samples from standing steers. Ten clinically normal steers were given intramuscular injections of gentamicin sulfate, 4 mg/kg body weight. Renal biopsy was performed at 5 separate times. After feed was withheld for 24 h, laparoscopic surgery was performed in standing stocks. Acepromazine, xylazine, and butorphanol were used for sedation and analgesia, and 2% lidocaine was used for local anesthesia. Two incisions approximately 2 cm long were made in the paralumbar fossa to allow for trocar introduction. The abdomen was insufflated with CO2 and, with endoscopic guidance, a biopsy forceps used to remove a kidney sample 2 to 3 mm in diameter, by either a left or a right abdominal approach. Each operation was recorded on videotape, and images were also captured with a digital medical device system. Respiration, heart rate, temperature, appetite, attitude, and postural positions were evaluated at 12, 24, 48, and 72 h after surgery. The 51 laparoscopic procedures provided 48 renal samples (approximately 100 mg each). The 1st and 2nd samples were from the right kidney, and the 3rd sample was from either the left or the right kidney; the 4th and 5th samples were from the left kidney. Adhesions made an approach from the right side difficult for the 3rd sample. No clinical changes were observed in 9 steers after the procedure. One steer died after the 3rd procedure owing to hemorrhage. JF - Canadian journal of veterinary research = Revue canadienne de recherche veterinaire AU - Chiesa, O Alberto AU - Cullison, Richard AU - Anderson, David E AU - Moulton, Keesla AU - Galuppo, Larry D AU - von Bredow, Jurgen AD - Center for Veterinary Medicine, Office of Research, Division of Residue Chemistry, Food & Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. ochiesa@cvm.fda.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 87 EP - 93 VL - 70 IS - 2 SN - 0830-9000, 0830-9000 KW - Gentamicins KW - 0 KW - Index Medicus KW - Animals KW - Videotape Recording KW - Gentamicins -- pharmacokinetics KW - Drug Residues -- analysis KW - Anesthesia, Local -- veterinary KW - Injections, Intramuscular -- veterinary KW - Male KW - Kidney -- pathology KW - Cattle -- surgery KW - Cattle Diseases -- diagnosis KW - Postoperative Complications -- epidemiology KW - Laparoscopy -- methods KW - Biopsy, Needle -- methods KW - Kidney -- chemistry KW - Postoperative Complications -- veterinary KW - Laparoscopy -- veterinary KW - Kidney Diseases -- diagnosis KW - Kidney Diseases -- veterinary KW - Biopsy, Needle -- veterinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67912142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+veterinary+research+%3D+Revue+canadienne+de+recherche+veterinaire&rft.atitle=Development+of+a+technique+for+serial+bilateral+renal+biopsy+in+steers.&rft.au=Chiesa%2C+O+Alberto%3BCullison%2C+Richard%3BAnderson%2C+David+E%3BMoulton%2C+Keesla%3BGaluppo%2C+Larry+D%3Bvon+Bredow%2C+Jurgen&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-04-01&rft.volume=70&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+veterinary+research+%3D+Revue+canadienne+de+recherche+veterinaire&rft.issn=08309000&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Vet Surg. 2001 Nov-Dec;30(6):559-63 [11704952] J Vet Pharmacol Ther. 2006 Apr;29(2):99-106 [16515663] Vet Surg. 2002 Mar-Apr;31(2):117-24 [11884956] J Vet Diagn Invest. 2003 Mar;15(2):195-200 [12661735] Biochim Biophys Acta. 1973 Nov 29;326(2):201-9 [4358092] J Toxicol Environ Health. 1977 Mar;2(4):787-801 [857041] Am J Vet Res. 1985 Mar;46(3):699-702 [3158259] Am J Vet Res. 1986 Apr;47(4):808-13 [3754403] Am J Vet Res. 1991 Dec;52(12):1933-9 [1789504] Vet Clin North Am Equine Pract. 1991 Dec;7(3):627-39 [1820230] Am J Vet Res. 1993 Jul;54(7):1170-6 [8368616] Am J Vet Res. 1995 Apr;56(4):518-31 [7785833] J Am Vet Med Assoc. 1998 Aug 15;213(4):523-5 [9713537] Vet Surg. 1999 Mar-Apr;28(2):106-12 [10100764] Schweiz Arch Tierheilkd. 1999;141(9):397-9, 402-6 [10500412] J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 5;821(1):22-30 [15905139] Am J Vet Res. 2002 Feb;63(2):289-94 [11843132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide rates in short-term randomized controlled trials of newer antidepressants. AN - 67887452; 16633153 AB - Concerns have been raised about the appropriateness of placebo controls in clinical trials for major depressive disorder (MDD), given that there are approved treatments for this illness. Critics have argued that patients with untreated depression would be exposed to an unnecessary risk of suicide. There is also a competing concern that antidepressant drug treatment itself may induce suicidal behavior and thinking (suicidality). To examine this question, we have evaluated the rate of suicide in placebo- and active drug-treated groups of patients with MDD and various anxiety disorders participating in short-term randomized controlled trials (RCTs). We examined data from all manufacturer-sponsored short-term RCTs of 9 commonly used antidepressants in patients with MDD and various anxiety disorders. All short-term RCTs of antidepressants in patients with MDD and various anxiety disorders were included. Individual patients' data were available for all trials. Data were available for the 207 trials conducted in patients with MDD, including a total of 40,028 patients. There were 21 cases of suicide in these patients. Forty-four trials were conducted in patients with various anxiety disorders, including a total of 10,972 patients. There were 2 cases of suicide in these patients. Overall, at least 1 case of suicide occurred in 21 of the 251 trials. Sixteen of the suicides in MDD trials occurred in trials that had only an active control comparison group, and most of these (14 cases) were observed in the non-North American trials. In the placebo-controlled MDD trials, the rate ratios of suicide in the combined drug groups compared with placebo were 1.07 (0.1-63.4) and 0.5 (0.0-36.7) for the non-North American and North American trials, respectively. In the anxiety disorder studies, the overall rate ratio of suicide for the selective serotonin reuptake inhibitors compared with placebo was 0.9 (0.0-71.4). Neither use of placebo nor of antidepressants in short-term RCTs was associated with an increased risk of completed suicide among patients with MDD or various anxiety disorders. Nonetheless, because of the small numbers of suicides in these trials and the subsequent lack of statistical power, an increased risk of completed suicide in association with either drug or placebo treatment cannot be definitively excluded. JF - Journal of clinical psychopharmacology AU - Hammad, Tarek A AU - Laughren, Thomas P AU - Racoosin, Judith A AD - Division of Neuropharmocological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. hammadt@cder.fda.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 203 EP - 207 VL - 26 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents KW - 0 KW - Placebos KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Psychiatric Status Rating Scales KW - Placebos -- adverse effects KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Depressive Disorder, Major -- drug therapy KW - Anxiety Disorders -- drug therapy KW - Anxiety Disorders -- psychology KW - Depressive Disorder, Major -- psychology KW - Antidepressive Agents -- adverse effects KW - Suicide -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67887452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Suicide+rates+in+short-term+randomized+controlled+trials+of+newer+antidepressants.&rft.au=Hammad%2C+Tarek+A%3BLaughren%2C+Thomas+P%3BRacoosin%2C+Judith+A&rft.aulast=Hammad&rft.aufirst=Tarek&rft.date=2006-04-01&rft.volume=26&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemotherapeutic approaches for targeting cell death pathways. AN - 67866046; 16614230 AB - For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death in mammalian tissues. It also has been increasingly noted that conventional chemotherapeutic agents not only elicit apoptosis but other forms of nonapoptotic death such as necrosis, autophagy, mitotic catastrophe, and senescence. This review presents background on the signaling pathways involved in the different cell death outcomes. A re-examination of what we know about chemotherapy-induced death is vitally important in light of new understanding of nonapoptotic cell death signaling pathways. If we can precisely activate or inhibit molecules that mediate the diversity of cell death outcomes, perhaps we can succeed in more effective and less toxic chemotherapeutic regimens. JF - The oncologist AU - Ricci, M Stacey AU - Zong, Wei-Xing AD - National Cancer Institute and Food and Drug Administration Interagency Oncology Task Force, Bethesda, Maryland, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 342 EP - 357 VL - 11 IS - 4 SN - 1083-7159, 1083-7159 KW - Antineoplastic Agents KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Receptors, Tumor Necrosis Factor KW - Index Medicus KW - Autophagy -- drug effects KW - Animals KW - Genes, Neoplasm -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Intracellular Signaling Peptides and Proteins -- drug effects KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Cell Aging -- drug effects KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Necrosis -- chemically induced KW - Apoptosis -- drug effects KW - Mitosis -- drug effects KW - Receptors, Tumor Necrosis Factor -- metabolism KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Signal Transduction -- drug effects KW - Cell Death -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67866046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Chemotherapeutic+approaches+for+targeting+cell+death+pathways.&rft.au=Ricci%2C+M+Stacey%3BZong%2C+Wei-Xing&rft.aulast=Ricci&rft.aufirst=M&rft.date=2006-04-01&rft.volume=11&rft.issue=4&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2004 Nov 5;306(5698):990-5 [15528435] J Biol Chem. 2004 Nov 12;279(46):48168-76 [15337764] Nat Cell Biol. 2004 Dec;6(12):1221-8 [15558033] Biochemistry (Mosc). 2002 Apr;67(4):387-408 [11996653] Cell. 2002 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Apr-Jul;20(4-7):401-10 [11563055] Mol Cell. 2001 Sep;8(3):613-21 [11583623] Cancer Res. 2001 Oct 15;61(20):7495-500 [11606385] Cancer Res. 2002 Mar 15;62(6):1876-83 [11912168] Int J Mol Med. 2002 May;9(5):521-5 [11956660] J Biol Chem. 2002 May 10;277(19):16448-55 [11880365] Curr Biol. 2003 Sep 2;13(17):1549-56 [12956959] J Biol Chem. 2003 Sep 12;278(37):35501-7 [12816951] J Med Chem. 2004 Aug 26;47(18):4417-26 [15317454] Science. 2004 Sep 3;305(5689):1466-70 [15353804] Science. 2004 Sep 3;305(5689):1471-4 [15353805] Cancer Res. 2004 Oct 15;64(20):7570-8 [15492284] Br J Cancer. 1972 Aug;26(4):239-57 [4561027] Arch Biochem Biophys. 1979 Jul;195(2):453-9 [383019] Arch Biochem Biophys. 1979 Jul;195(2):460-7 [38751] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of chelation on blood pressure in lead-exposed children: a randomized study. AN - 67818816; 16581549 AB - Studies in children suggest a weak association between blood lead concentration and blood pressure. To understand this better, we tested the strength of the association in children with elevated blood lead concentrations and whether succimer chelation changed blood pressure as it did blood lead. In a randomized clinical trial of 780 children with blood lead concentrations of 20-44 microg/dL at 12-33 months of age, we compared the systolic and diastolic blood pressure in the succimer-treated group and placebo group for up to 5 years of follow-up. We also analyzed the relation of blood lead to blood pressure. Children in the succimer group had lower blood lead concentrations for 9-10 months during and after treatment, but their blood pressure did not differ from those in the placebo group during this period. During 1-5 years of follow-up, children in the succimer group had systolic blood pressure 1.09 (95% confidence interval, 0.27-1.90) mmHg higher than did untreated children in a model with repeated measurements, but the difference in diastolic blood pressure was not statistically significant. No association between blood lead and blood pressure was found. Overall, there is no association between blood lead and blood pressure in these children with moderately high lead exposure, nor does chelation with succimer change blood pressure. JF - Environmental health perspectives AU - Chen, Aimin AU - Rhoads, George G AU - Cai, Bo AU - Salganik, Mikhail AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 579 EP - 583 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - Chelating Agents KW - 0 KW - Placebos KW - Lead KW - 2P299V784P KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Child KW - Child, Preschool KW - Chelating Agents -- pharmacology KW - Lead -- toxicity KW - Blood Pressure -- drug effects KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67818816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+effect+of+chelation+on+blood+pressure+in+lead-exposed+children%3A+a+randomized+study.&rft.au=Chen%2C+Aimin%3BRhoads%2C+George+G%3BCai%2C+Bo%3BSalganik%2C+Mikhail%3BRogan%2C+Walter+J&rft.aulast=Chen&rft.aufirst=Aimin&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-28 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2003 Mar 26;289(12):1523-32 [12672769] Environ Res. 1998 Feb;76(2):107-13 [9515065] Environ Res. 2004 Feb;94(2):120-33 [14757375] Am J Epidemiol. 2001 Jan 15;153(2):164-71 [11159162] N Engl J Med. 2001 May 10;344(19):1421-6 [11346806] J Hum Hypertens. 2002 Feb;16(2):123-31 [11850770] J Hum Hypertens. 2002 Aug;16(8):563-8 [12149662] Am J Ind Med. 2004 May;45(5):446-54 [15095427] Pediatrics. 2004 Jul;114(1):19-26 [15231903] Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76 [15286277] J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):517-9 [739230] Pediatrics. 1979 Apr;63(4):674-6 [440885] Arch Environ Health. 1981 Nov-Dec;36(6):310-5 [7316569] J Lab Clin Med. 1982 Mar;99(3):354-62 [7057062] Proc Soc Exp Biol Med. 1982 May;170(1):63-7 [7043471] Am J Ind Med. 1987;11(2):145-56 [3826077] Med Toxicol. 1987 May-Jun;2(3):210-32 [3298924] Analyst. 1987 Dec;112(12):1701-4 [3445938] J Pediatr. 1988 Oct;113(4):751-7 [2845043] Environ Health Perspect. 1988 Jun;78:71-6 [3060353] Environ Health Perspect. 1988 Jun;78:85-9 [3060355] Am J Dis Child. 1991 Jun;145(6):681-7 [2035497] Paediatr Perinat Epidemiol. 1998 Jul;12(3):313-33 [9690266] Environ Health Perspect. 1998 Nov;106(11):745-50 [9799191] Am J Epidemiol. 2002 Dec 15;156(12):1079-87 [12480651] Hypertension. 2003 Mar;41(3):463-8 [12623944] JAMA. 1992 May 6;267(17):2340-3 [1564773] Epidemiol Rev. 1993;15(2):352-73 [8174662] J Environ Pathol Toxicol Oncol. 1993 Oct-Dec;12(4):213-8 [8189378] Curr Opin Nephrol Hypertens. 1994 May;3(3):257-63 [7922250] J Am Coll Nutr. 1994 Dec;13(6):578-83 [7706590] J Pediatr. 1995 Aug;127(2):186-92 [7636641] Circulation. 1995 Aug 15;92(4):1049-57 [7641339] Epidemiology. 1996 Nov;7(6):633-7 [8899391] N Engl J Med. 1996 Dec 26;335(26):1968-73 [8960478] Hypertension. 2003 Sep;42(3):e9; author reply e9 [12885798] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Workgroup report: Review of genomics data based on experience with mock submissions--view of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee. AN - 67818786; 16581548 AB - Over the past few years, both the U.S. Food and Drug Administration (FDA) and the pharmaceutical industry have recognized the potential importance of pharmacogenomics and toxicogenomics to drug development. To resolve the uncertainties surrounding the use of microarray technology and the presentation of genomics data for regulatory purposes, several pharmaceutical companies and genomics technology providers have provided the FDA with reports of genomics studies that included supporting toxicology data (e.g., serum chemistry, histopathology). These studies were not associated with any active drug application and were exploratory or hypothesis generating in nature. For training purposes, these reports were reviewed by the Nonclinical Pharmacogenomics Subcommittee consisting of the Center for Drug Evaluation and Research pharmacology and toxicology researchers and reviewers. In this article, we describe some of these submissions and report on our assessment of data content, format, and quality control metrics that were useful for evaluating these nonclinical genomics submissions, specifically in relation to the proposed MIAME/MINTox (minimum information about a microarray experiment/minimum information needed for a toxicology experiment) recommendations. These genomics submissions allowed both researchers and regulators to gain experience in the process of reviewing and analyzing toxicogenomics data. The experience will allow development of recommendations for the submission and review of these data as the state of the science evolves. JF - Environmental health perspectives AU - Leighton, John K AU - Brown, Paul AU - Ellis, Amy AU - Harlow, Patricia AU - Harrouk, Wafa AU - Pine, P Scott AU - Robison, Timothy AU - Rosario, Lilliam AU - Thompson, Karol AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. leightonj@fda.hhs.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 573 EP - 578 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Animals KW - Education KW - Oligonucleotide Array Sequence Analysis KW - Database Management Systems KW - Toxicology KW - Pharmacogenetics KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67818786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Workgroup+report%3A+Review+of+genomics+data+based+on+experience+with+mock+submissions--view+of+the+CDER+Pharmacology+Toxicology+Nonclinical+Pharmacogenomics+Subcommittee.&rft.au=Leighton%2C+John+K%3BBrown%2C+Paul%3BEllis%2C+Amy%3BHarlow%2C+Patricia%3BHarrouk%2C+Wafa%3BPine%2C+P+Scott%3BRobison%2C+Timothy%3BRosario%2C+Lilliam%3BThompson%2C+Karol&rft.aulast=Leighton&rft.aufirst=John&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-28 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2001 Dec;29(4):365-71 [11726920] Science. 2002 Apr 12;296(5566):340-3 [11951044] Genet Epidemiol. 2002 Jun;23(1):21-36 [12112246] Toxicol Sci. 2005 Nov;88(1):250-64 [16081524] Environ Health Perspect. 2004 Mar;112(4):417-9 [15033589] Science. 2004 Oct 22;306(5696):575 [15498974] Genome Res. 2005 May;15(5):674-80 [15867429] Biotechniques. 2002 Sep;33(3):516-8, 520, 522 passim [12238761] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies. AN - 67816502; 16581542 AB - In rodent cancer bioassays, groups of animals are exposed to different doses of a chemical of interest and followed for tumor occurrence. The resulting tumor rates are commonly analyzed using a survival-adjusted Cochran-Armitage (CA) trend test. The CA trend test has reasonable power when the tumor-response curve is linear in dose, but it may be underpowered for a nonlinear response. An alternative survival-adjusted test procedure based on isotonic regression methodology has previously been proposed. Although this alternative procedure performs well when the tumor response is nonlinear in dose, it has less power than the CA trend test when the response is linear in dose. Here, we introduce a new survival-adjusted test procedure that makes use of both the CA trend test and the isotonic regression-based trend test. Using a broad range of experimental conditions typical of National Toxicology Program (NTP) bioassays, we conducted extensive computer simulations to compare the false-positive error rate and power of the proposed procedure with the survival-adjusted CA trend test. The new procedure competes well with the survival-adjusted CA trend test when observed tumor rates are linear in dose and performs substantially better when observed tumor rates are nonlinear in dose. Further, the proposed trend test almost always has a smaller false-positive rate than does the survival-adjusted CA trend test. We also developed an order-restricted inference-based procedure for performing multiple pairwise comparisons between each of the dose groups and the control group. The trend test and the multiple pairwise comparisons test are demonstrated using an example from a study conducted by the NTP. JF - Environmental health perspectives AU - Peddada, Shyamal D AU - Kissling, Grace E AD - Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. peddada@niehs.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 537 EP - 541 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Nonlinear Dynamics KW - Female KW - Neoplasms, Experimental -- epidemiology KW - Neoplasms, Experimental -- chemically induced KW - Carcinogenicity Tests KW - Survival Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67816502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+survival-adjusted+quantal-response+test+for+analysis+of+tumor+incidence+rates+in+animal+carcinogenicity+studies.&rft.au=Peddada%2C+Shyamal+D%3BKissling%2C+Grace+E&rft.aulast=Peddada&rft.aufirst=Shyamal&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-28 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 2001 Dec;57(4):1219-27 [11764263] Biometrics. 1988 Jun;44(2):417-31 [3390507] Biometrics. 1993 Sep;49(3):793-801 [8241374] Biometrics. 1991 Jun;47(2):681-700 [1912267] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hy's law: predicting serious hepatotoxicity. AN - 67810433; 16552790 JF - Pharmacoepidemiology and drug safety AU - Temple, Robert AD - US Food and Drug Administration. robert.temple@hhs.fda.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 241 EP - 243 VL - 15 IS - 4 SN - 1053-8569, 1053-8569 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticoagulants KW - Azetidines KW - Benzophenones KW - Benzylamines KW - Biomarkers KW - Bromobenzenes KW - Chromans KW - Hypoglycemic Agents KW - Thiazolidinediones KW - ximelagatran KW - 49HFB70472 KW - bromfenac KW - 864P0921DW KW - Alanine Transaminase KW - EC 2.6.1.2 KW - troglitazone KW - I66ZZ0ZN0E KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - United States KW - Benzophenones -- adverse effects KW - Randomized Controlled Trials as Topic KW - Azetidines -- adverse effects KW - Humans KW - Thiazolidinediones -- adverse effects KW - Predictive Value of Tests KW - Chromans -- adverse effects KW - Risk Assessment KW - Alanine Transaminase -- blood KW - Benzylamines -- adverse effects KW - United States Food and Drug Administration KW - Adverse Drug Reaction Reporting Systems KW - Drug Approval KW - Bilirubin -- blood KW - Bromobenzenes -- adverse effects KW - Biomarkers -- blood KW - Chemical and Drug Induced Liver Injury -- blood KW - Liver -- enzymology KW - Chemical and Drug Induced Liver Injury -- etiology KW - Liver -- drug effects KW - Anticoagulants -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Chemical and Drug Induced Liver Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Hy%27s+law%3A+predicting+serious+hepatotoxicity.&rft.au=Temple%2C+Robert&rft.aulast=Temple&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=15&rft.issue=4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):221-9 [16444771] Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):213-20 [16456879] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - How can 'Hy's law' help the clinician? AN - 67807223; 16552792 JF - Pharmacoepidemiology and drug safety AU - Senior, John R AD - Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration HFD-030, Silver Spring, MD 20993, USA. seniorj@cder.fda.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 235 EP - 239 VL - 15 IS - 4 SN - 1053-8569, 1053-8569 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticoagulants KW - Azetidines KW - Benzophenones KW - Benzylamines KW - Biomarkers KW - Bromobenzenes KW - Chromans KW - Hypoglycemic Agents KW - Thiazolidinediones KW - ximelagatran KW - 49HFB70472 KW - bromfenac KW - 864P0921DW KW - Alanine Transaminase KW - EC 2.6.1.2 KW - troglitazone KW - I66ZZ0ZN0E KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - Alanine Transaminase -- blood KW - United States Food and Drug Administration KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Drug Approval KW - Predictive Value of Tests KW - Bilirubin -- blood KW - Biomarkers -- blood KW - Risk Assessment KW - Chemical and Drug Induced Liver Injury -- blood KW - Benzophenones -- adverse effects KW - Liver -- enzymology KW - Azetidines -- adverse effects KW - Thiazolidinediones -- adverse effects KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Chromans -- adverse effects KW - Benzylamines -- adverse effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Liver -- drug effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Anticoagulants -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Bromobenzenes -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67807223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=How+can+%27Hy%27s+law%27+help+the+clinician%3F&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2006-04-01&rft.volume=15&rft.issue=4&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=10538569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):221-9 [16444771] Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):213-20 [16456879] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. AN - 67772114; 16339183 AB - Although the toxicity of benzene has been linked to its metabolism, the dose-related production of metabolites is not well understood in humans, particularly at low levels of exposure. We investigated unmetabolized benzene in urine (UBz) and all major urinary metabolites [phenol (PH), E,E-muconic acid (MA), hydroquinone (HQ) and catechol (CA)] as well as the minor metabolite, S-phenylmercapturic acid (SPMA), in 250 benzene-exposed workers and 139 control workers in Tianjin, China. Median levels of benzene exposure were approximately 1.2 p.p.m. for exposed workers (interquartile range: 0.53-3.34 p.p.m.) and 0.004 p.p.m. for control workers (interquartile range: 0.002-0.007 p.p.m.). (Exposures of control workers to benzene were predicted from levels of benzene in their urine.) Metabolite production was investigated among groups of 30 workers aggregated by their benzene exposures. We found that the urine concentration of each metabolite was consistently elevated when the group's median benzene exposure was at or above the following air concentrations: 0.2 p.p.m. for MA and SPMA, 0.5 p.p.m. for PH and HQ, and 2 p.p.m. for CA. Dose-related production of the four major metabolites and total metabolites (micromol/l/p.p.m. benzene) declined between 2.5 and 26-fold as group median benzene exposures increased between 0.027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures. JF - Carcinogenesis AU - Kim, Sungkyoon AU - Vermeulen, Roel AU - Waidyanatha, Suramya AU - Johnson, Brent A AU - Lan, Qing AU - Rothman, Nathaniel AU - Smith, Martyn T AU - Zhang, Luoping AU - Li, Guilan AU - Shen, Min AU - Yin, Songnian AU - Rappaport, Stephen M AD - School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 772 EP - 781 VL - 27 IS - 4 SN - 0143-3334, 0143-3334 KW - Catechols KW - 0 KW - Hydroquinones KW - Phenol KW - 339NCG44TV KW - muconic acid KW - 3KD92ZL2KH KW - S-phenyl-N-acetylcysteine KW - 4775-80-8 KW - Benzene KW - J64922108F KW - catechol KW - LF3AJ089DQ KW - Acetylcysteine KW - WYQ7N0BPYC KW - Sorbic Acid KW - X045WJ989B KW - hydroquinone KW - XV74C1N1AE KW - Index Medicus KW - Acetylcysteine -- analogs & derivatives KW - Dose-Response Relationship, Drug KW - Humans KW - Phenol -- urine KW - Hydroquinones -- urine KW - Catechols -- urine KW - Acetylcysteine -- urine KW - Sorbic Acid -- analogs & derivatives KW - Adult KW - Case-Control Studies KW - Sorbic Acid -- analysis KW - Middle Aged KW - Urinalysis KW - Adolescent KW - Female KW - Male KW - Occupational Exposure KW - Benzene -- metabolism KW - Benzene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67772114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Using+urinary+biomarkers+to+elucidate+dose-related+patterns+of+human+benzene+metabolism.&rft.au=Kim%2C+Sungkyoon%3BVermeulen%2C+Roel%3BWaidyanatha%2C+Suramya%3BJohnson%2C+Brent+A%3BLan%2C+Qing%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BLi%2C+Guilan%3BShen%2C+Min%3BYin%2C+Songnian%3BRappaport%2C+Stephen+M&rft.aulast=Kim&rft.aufirst=Sungkyoon&rft.date=2006-04-01&rft.volume=27&rft.issue=4&rft.spage=772&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High caffeine intake in adolescents: associations with difficulty sleeping and feeling tired in the morning. AN - 67769930; 16549311 AB - The objective of this study was to examine the association between caffeine usage in U.S. adolescents and the frequency that feeling tired in the morning and having difficulty sleeping is reported. In this study we found that feeling tired in the morning and having difficulty sleeping was experienced more commonly in those adolescents that have a high intake of caffeine. JF - The Journal of adolescent health : official publication of the Society for Adolescent Medicine AU - Orbeta, Rebecca L AU - Overpeck, Mary D AU - Ramcharran, Darmendra AU - Kogan, Michael D AU - Ledsky, Rebecca AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland 20857, USA. btingle76@yahoo.com Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 451 EP - 453 VL - 38 IS - 4 KW - Central Nervous System Stimulants KW - 0 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Fatigue KW - Humans KW - Health Surveys KW - Drinking Behavior KW - Adolescent KW - Male KW - Female KW - Sleep Wake Disorders -- diagnosis KW - Adolescent Behavior KW - Caffeine -- adverse effects KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67769930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+adolescent+health+%3A+official+publication+of+the+Society+for+Adolescent+Medicine&rft.atitle=High+caffeine+intake+in+adolescents%3A+associations+with+difficulty+sleeping+and+feeling+tired+in+the+morning.&rft.au=Orbeta%2C+Rebecca+L%3BOverpeck%2C+Mary+D%3BRamcharran%2C+Darmendra%3BKogan%2C+Michael+D%3BLedsky%2C+Rebecca&rft.aulast=Orbeta&rft.aufirst=Rebecca&rft.date=2006-04-01&rft.volume=38&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+adolescent+health+%3A+official+publication+of+the+Society+for+Adolescent+Medicine&rft.issn=1879-1972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-04 N1 - Date created - 2006-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Projecting drug use among aging baby boomers in 2020. AN - 67761887; 16275134 AB - Greater rates of lifetime drug use among the baby-boom generation, combined with the size of that generation, suggest that the number of elderly persons using drugs will increase in the next two decades. Given the potential public health demands implied by increasing numbers of elderly drug users, the goal is to project the numbers of current drug users aged 50 years and older in 2020. Using the modeling and projection methods of Gfroerer et al (2003) applied to data from the 1999 to 2001 National Household Surveys on Drug Abuse, projections were developed for the use of marijuana, nonmedical use of any prescription-type psychotherapeutic drug, and any illicit drug use. From 1999 to 2001 to 2020, past-year marijuana use in persons 50 years and older is forecast to increase from 1.0% to 2.9%. The number of users is expected to increase from 719,000 to almost 3.3 million, reflecting the combined effects of the increase in rate of use and a projected 51.9% increase in the civilian noninstitutionalized population in this age group. Use of any illicit drug will increase from 2.2% (1.6 million) to 3.1% (3.5 million), and nonmedical use of psychotherapeutic drugs will increase from 1.2% (911,000) to 2.4% (almost 2.7 million). These projections call attention to changes to be considered in planning and to the need for improved knowledge of the biomedical and psychosocial effects of nonmedical drug use on aging and elderly individuals. JF - Annals of epidemiology AU - Colliver, James D AU - Compton, Wilson M AU - Gfroerer, Joseph C AU - Condon, Timothy AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 257 EP - 265 VL - 16 IS - 4 SN - 1047-2797, 1047-2797 KW - Index Medicus KW - Odds Ratio KW - Age of Onset KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Data Collection KW - United States -- epidemiology KW - Male KW - Female KW - Cohort Effect KW - Forecasting KW - Health Services Needs and Demand -- trends KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67761887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Projecting+drug+use+among+aging+baby+boomers+in+2020.&rft.au=Colliver%2C+James+D%3BCompton%2C+Wilson+M%3BGfroerer%2C+Joseph+C%3BCondon%2C+Timothy&rft.aulast=Colliver&rft.aufirst=James&rft.date=2006-04-01&rft.volume=16&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Salivary gland gene therapy. AN - 67743373; 16530055 AB - Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract. JF - Dental clinics of North America AU - Cotrim, Ana P AU - Mineshiba, Fumi AU - Sugito, Takayuki AU - Samuni, Yuval AU - Baum, Bruce J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1190, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 157 EP - 73, vii VL - 50 IS - 2 SN - 0011-8532, 0011-8532 KW - Proteins KW - 0 KW - Dentistry KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Head and Neck Neoplasms -- complications KW - Sjogren's Syndrome -- therapy KW - Radiation Injuries -- therapy KW - Head and Neck Neoplasms -- radiotherapy KW - Proteins -- metabolism KW - Proteins -- genetics KW - Sjogren's Syndrome -- genetics KW - Salivary Glands -- injuries KW - Salivary Gland Diseases -- therapy KW - Salivary Gland Diseases -- complications KW - Genetic Therapy -- methods KW - Drug Delivery Systems -- methods KW - Salivary Glands -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67743373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dental+clinics+of+North+America&rft.atitle=Salivary+gland+gene+therapy.&rft.au=Cotrim%2C+Ana+P%3BMineshiba%2C+Fumi%3BSugito%2C+Takayuki%3BSamuni%2C+Yuval%3BBaum%2C+Bruce+J&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=50&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Dental+clinics+of+North+America&rft.issn=00118532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a high-efficiency, filter-bank system. AN - 67738523; 16531293 AB - National Institute for Occupational Safety and Health (NIOSH) investigators evaluated filtration efficiencies at three U.S. Postal Service (USPS) facilities. Ventilation and filtration systems (VFSs) had been installed after the 2001 bioterrorist attacks when the USPS unknowingly processed letters laden with B. anthracis spores. The new VFS units included high-efficiency particulate air (HEPA) filters and were required by USPS contract specifications to provide an overall filtration efficiency of at least 99.97% for particles between 0.3 microm and 3.0 micro m. The USPS evaluation involved a modification of methodology used to test total filtration system efficiency in agricultural tractor cab enclosures. The modified sampling strategy not only proved effective for monitoring the total filtration system component of VFS performance but also distinguished between filtration systems performing to the high USPS performance criteria and those needing repair or replacement. The results clearly showed the importance of choosing a pair of optical particle counters that have been closely matched immediately prior to testing. The modified methodology is readily adaptable to any workplace wishing to evaluate air filtration systems, including high-efficiency systems. JF - Journal of occupational and environmental hygiene AU - Martin, Stephen B AU - Beamer, Bryan R AU - Moyer, Ernest S AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 204 EP - 13; quiz D45 VL - 3 IS - 4 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Filtration KW - Optics and Photonics KW - Particle Size KW - Humans KW - Workplace KW - National Institute for Occupational Safety and Health (U.S.) KW - Ventilation KW - Bioterrorism KW - Air Pollution, Indoor -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67738523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Evaluation+of+a+high-efficiency%2C+filter-bank+system.&rft.au=Martin%2C+Stephen+B%3BBeamer%2C+Bryan+R%3BMoyer%2C+Ernest+S&rft.aulast=Martin&rft.aufirst=Stephen&rft.date=2006-04-01&rft.volume=3&rft.issue=4&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-09 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Air contaminant exposures among Transportation Security Administration (TSA) "checked baggage" screeners at four international airports. AN - 67707233; 16507517 JF - Journal of occupational and environmental hygiene AU - Mazzuckelli, Lawrence AU - Methner, Mark M AU - Delaney, Lisa J AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - D36 EP - D41 VL - 3 IS - 4 SN - 1545-9624, 1545-9624 KW - Vehicle Emissions KW - 0 KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Aviation -- standards KW - Humans KW - Occupational Exposure KW - Air Pollution, Indoor -- analysis KW - Security Measures KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67707233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Air+contaminant+exposures+among+Transportation+Security+Administration+%28TSA%29+%22checked+baggage%22+screeners+at+four+international+airports.&rft.au=Mazzuckelli%2C+Lawrence%3BMethner%2C+Mark+M%3BDelaney%2C+Lisa+J&rft.aulast=Mazzuckelli&rft.aufirst=Lawrence&rft.date=2006-04-01&rft.volume=3&rft.issue=4&rft.spage=D36&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-09 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - What Is Child Abuse and Neglect? AN - 62032685; ED499058 AB - Each State provides its own definitions of child abuse and neglect based on minimum standards set by Federal law. This fact sheet provides the answers to the following questions: (1) How is child abuse and neglect defined in Federal law?; and (2) What are the major types of child abuse and neglect? Additional resources are listed. (Contains 2 footnotes.) Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 4 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Parent Responsibility KW - Federal Legislation KW - Access to Education KW - Child Health KW - Child Neglect KW - Mental Health KW - Standards KW - Child Abuse KW - Child Welfare KW - Legal Responsibility KW - Physical Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62032685?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Keep Kids Alcohol Free: Strategies for Action AN - 62028148; ED496019 AB - This guide is a starting point for parents, teachers, health professionals, law enforcement personnel, alcohol retailers, policymakers, and others who are concerned with the well-being of children. It describes three basic prevention strategies and ways they can be applied in the home, the school, and the community, and offers effective, practical strategies for communities that have decided to take action to prevent underage drinking, especially among children and young adolescents. These strategies may lead to such changes as revised zoning laws, new policies or legislation, better enforcement of existing laws, and establishment of school policies on alcohol use. To help the reader better understand how to put these strategies into action, the guide also includes real-life examples of efforts by people around the country to prevent drinking by 9- to 15-year-olds. Although the strategies may be adapted in different ways by different communities, their science base ensures that no matter what the location, from rural farming areas, to suburban school districts, to inner-city neighborhoods, these strategies work. Also included are: (1) a list of materials offered by the federal agency funding partners in this initiative, that will be useful to those who are developing prevention campaigns in their communities; and (2) A list of directories of individual State agencies or regional offices that can provide local resources. (Contains 38 endnotes.) [This document was produced by The Leadership to Keep Children Alcohol Free.] Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 19 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Parents KW - Teachers KW - Policymakers KW - Elementary Secondary Education KW - Grade 10 KW - Grade 5 KW - Grade 6 KW - Grade 7 KW - Grade 8 KW - Grade 9 KW - Drinking KW - Prevention KW - Public Agencies KW - Law Enforcement KW - Directories KW - Preadolescents KW - Neighborhoods KW - Legislation KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62028148?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2005 AN - 62000707; ED494054 AB - Substance use by American young people has proven to be a rapidly-changing phenomenon, requiring frequent assessments and reassessments. Since the mid-1960s it has remained a major concern for the nation. Smoking, drinking, and illicit drug use are leading causes of morbidity and mortality, both during adolescence as well as later in life. How vigorously the nation responds to teenage substance use, how accurately it identifies the substance abuse problems that are emerging, and how well it comes to understand the effectiveness of the many policy and intervention efforts largely depend on the ongoing collection of valid and reliable data. Monitoring the Future is designed to help provide an accurate picture of what is happening in this domain and why; and it has served that function for 31 years now. First results from the Monitoring the Future study's 2005 nationwide survey of nearly 50,000 8th, 10th and 12th-grade students are given in this report. Recent trends in the use of licit and illicit drugs are emphasized. Trends in the levels of perceived risk and personal disapproval associated with each drug are also presented; this study has shown these beliefs and attitudes to be particularly important in explaining trends in use. In addition, trends in the perceived availability of each drug are presented. Following a brief introduction, the report presents a synopsis of the methods used in the study and an overview of the key results from the 2005 survey. Next is a section for each individual drug class, providing figures that show trends in the overall proportions of students at each grade level (a) using it, (b) seeing a "great risk" associated with its use, (c) disapproving of its use, and (d) saying that they could get the drug "fairly easily" or "very easily." Trends for the interval 1991-2005 appear for all grades and for 1975-2005 for the 12th graders. The tables at the end of this report provide the statistics underlying the figures; present data on lifetime, annual, 30-day, and (for selected drugs) daily prevalence. (Contains 13 tables.) AU - Johnston, Lloyd D. AU - O'Malley, Patrick M. AU - Bachman, Jerald G. AU - Schulenberg, John E. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 73 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Grade 10 KW - Grade 12 KW - Grade 8 KW - Drinking KW - At Risk Persons KW - Substance Abuse KW - Stimulants KW - Narcotics KW - National Surveys KW - Marijuana KW - Smoking KW - Alcohol Abuse KW - Student Attitudes KW - Attitude Measures KW - Cocaine KW - Drug Use KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62000707?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Perspectives On Marketing, Self-Regulation, & Childhood Obesity AN - 58747078; 2007-10501 AB - A report recommending concrete steps that industry can take to change their marketing and other practices to make progress against childhood obesity. The report is a product of last summer's joint FTC/HHS workshop, which provided a forum for industry, consumer, academic, and government stakeholders to examine the role of the private sector in addressing rising childhood obesity rates in the United States. Appendixes. JF - United States Federal Trade Commission, Apr 2006, 138 pp. AU - Federal Trade Commission AU - Department of Health and Human Services Y1 - 2006/04// PY - 2006 DA - April 2006 EP - 138p PB - United States Federal Trade Commission KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Health and health policy KW - Obesity - Prevention KW - Child health - United States KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58747078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Federal+Trade+Commission%3BDepartment+of+Health+and+Human+Services&rft.aulast=Federal+Trade+Commission&rft.aufirst=&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=138p&rft.isbn=&rft.btitle=Perspectives+On+Marketing%2C+Self-Regulation%2C+%26+Childhood+Obesity&rft.title=Perspectives+On+Marketing%2C+Self-Regulation%2C+%26+Childhood+Obesity&rft.issn=&rft_id=info:doi/ L2 - http://www.ftc.gov/os/2006/05/PerspectivesOnMarketingSelf-Regulation&ChildhoodObesityFTCandHHSReportonJointWorkshop.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-06-19 N1 - Publication note - United States Federal Trade Commission, 2006 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - A Comparison of Mothers with Co-occurring Disorders and Histories of Violence Living with or Separated from Minor Children AN - 57298337; 200916226 AB - Data from the Women with Co-occurring Disorders and Histories of Violence Study are used to examine characteristics distinguishing mothers currently providing care for all their minor children (n = 558) from mothers separated from one or more minor children (n = 1396). Mothers are described and compared on background characteristics and experiences, well-being and current functioning, situational context, and services used. Analyses control for number of children, race, and years of education. Mothers separated from children have more children, less education, have more often been homeless, in juvenile detention or jail, and have lower incomes than mothers living with all their children. Mothers separated from children have more extensive experiences of traumatic and stressful life events, and the groups differ in current functioning and patterns of services used. While cross-sectional data do not allow causal inferences, challenges faced by mothers have significant implications for policy and programs. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Nicholson, Joanne AU - Finkelstein, Norma AU - Williams, Valerie AU - Thom, Jennifer AU - Noether, Chanson AU - Devilbiss, Megan AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 225 EP - 243 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 33 IS - 2 SN - 1094-3412, 1094-3412 KW - Child protection KW - Violence KW - Noncustodial mothers KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57298337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=A+Comparison+of+Mothers+with+Co-occurring+Disorders+and+Histories+of+Violence+Living+with+or+Separated+from+Minor+Children&rft.au=Nicholson%2C+Joanne%3BFinkelstein%2C+Norma%3BWilliams%2C+Valerie%3BThom%2C+Jennifer%3BNoether%2C+Chanson%3BDevilbiss%2C+Megan&rft.aulast=Nicholson&rft.aufirst=Joanne&rft.date=2006-04-01&rft.volume=33&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-006-9015-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Child protection; Noncustodial mothers; Violence; Comorbidity DO - http://dx.doi.org/10.1007/s11414-006-9015-5 ER - TY - JOUR T1 - A Neuroscientist--Consumer Alliance to Transform Mental Health Care AN - 57272074; 200914180 AB - The field of mental health has long suffered from a lack of convergence of disciplines that deal with the mind, the brain, and behavior. This mind--brain dualism has been particularly detrimental for consumers and their families who daily face stigma and discrimination. The understanding of the brain and its dysfunctions has benefited from the study of the human genome and, in particular, of the mutations and variations in its code. This analysis permits a better understanding of the biological basis of mental disease and will soon inform a generation of new diagnostic tools and individualized pharmacological therapies. A biological perspective on mental illness will be complemented by the analysis of the social factors influencing people's behavior and their impact on brain biology and gene function. Neurobiology has progressed to a level for which the knowledge that is generated, even if still colored with uncertainty, could represent a catalyst for the creation of an alliance between neuroscientists and consumers. This partnership has the potential to benefit both parties but will require some concrete steps that might be outside of the usual courses of action for both consumers and scientists. It is by building collaborations based on personal contact and information sharing that a transformation of the mental health care system can occur. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Compagni, Amelia AU - Manderscheid, Ronald W AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, MD 20853, USA Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 265 EP - 274 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 33 IS - 2 SN - 1094-3412, 1094-3412 KW - Mental health care KW - Neurobiology KW - Brain KW - Partnerships KW - Consumers KW - Treatment methods KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57272074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=A+Neuroscientist--Consumer+Alliance+to+Transform+Mental+Health+Care&rft.au=Compagni%2C+Amelia%3BManderscheid%2C+Ronald+W&rft.aulast=Compagni&rft.aufirst=Amelia&rft.date=2006-04-01&rft.volume=33&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-006-9011-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Brain; Neurobiology; Consumers; Partnerships; Mental health care; Treatment methods DO - http://dx.doi.org/10.1007/s11414-006-9011-9 ER - TY - JOUR T1 - Health Care Workers and Asthma AN - 57160405; 200606455 AB - Asthma can develop at any time during a persons life, and it has been estimated that at least 15 percent of adult asthma cases may be work-related, with a high percentage of these being health care workers. This article discusses occupational asthma, its causes, and the methods nurses can use to protect themselves and their patients. 1 sidebar. Adapted from source document JF - American Journal of Nursing AU - Filios, Margaret S AU - Pechter, Elise AD - U.S. Public Health Service, National Instit Occupational Safety & Health, Division Respiratory Disease Studi Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 96 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 106 IS - 4 SN - 0002-936X, 0002-936X KW - Occupational health and safety KW - Nurses KW - Occupational asthma KW - Work environment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57160405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nursing&rft.atitle=Health+Care+Workers+and+Asthma&rft.au=Filios%2C+Margaret+S%3BPechter%2C+Elise&rft.aulast=Filios&rft.aufirst=Margaret&rft.date=2006-04-01&rft.volume=106&rft.issue=4&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Occupational asthma; Work environment; Occupational health and safety ER - TY - JOUR T1 - Measurement and analysis of mining-induced seismic ground motion in the vicinity of the West Elk Coal Mine, Somerset, CO AN - 51111380; 2006-085132 JF - Seismological Research Letters AU - Swanson, P AU - Koontz, W AU - Prentice, Carol AU - Ellsworth, William AU - Hellweg, Peggy Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 318 PB - Seismological Society of America, El Cerrito, CA VL - 77 IS - 2 SN - 0895-0695, 0895-0695 KW - United States KW - mining KW - mines KW - geologic hazards KW - geophysical methods KW - coal mines KW - Gunnison County Colorado KW - reflection methods KW - seismic sources KW - seismic methods KW - Somerset Colorado KW - seismicity KW - mining geology KW - earthquake prediction KW - seismic risk KW - ground motion KW - risk assessment KW - Colorado KW - earthquakes KW - West Elk Coal Mine KW - 19:Seismology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51111380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seismological+Research+Letters&rft.atitle=Measurement+and+analysis+of+mining-induced+seismic+ground+motion+in+the+vicinity+of+the+West+Elk+Coal+Mine%2C+Somerset%2C+CO&rft.au=Swanson%2C+P%3BKoontz%2C+W%3BPrentice%2C+Carol%3BEllsworth%2C+William%3BHellweg%2C+Peggy&rft.aulast=Swanson&rft.aufirst=P&rft.date=2006-04-01&rft.volume=77&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Seismological+Research+Letters&rft.issn=08950695&rft_id=info:doi/ L2 - http://srl.geoscienceworld.org/ LA - English DB - GeoRef N1 - Conference title - 2006 Annual meeting, Seismological Society of America; 100th anniversary earthquake conference N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - CA N1 - Last updated - 2016-10-25 N1 - CODEN - EAQNAT N1 - SubjectsTermNotLitGenreText - coal mines; Colorado; earthquake prediction; earthquakes; geologic hazards; geophysical methods; ground motion; Gunnison County Colorado; mines; mining; mining geology; reflection methods; risk assessment; seismic methods; seismic risk; seismic sources; seismicity; Somerset Colorado; United States; West Elk Coal Mine ER - TY - CPAPER T1 - Chlorophyllin Differentially Modulates CYP1 Gene Expression in Normal Human Mammary Epithelial Cells (NHMECs) Exposed to Benzopyrenes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40016057; 4185568 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - John, Kaarthik AU - Divi, Rao L AU - Keshava, Channa AU - Whipkey, Diana L AU - Poirier, Miriam C AU - Weston, Ainsley AU - Nath, Joginder Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Epithelial cells KW - Mammary gland KW - CYP1 gene KW - Chlorophyllin KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40016057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chlorophyllin+Differentially+Modulates+CYP1+Gene+Expression+in+Normal+Human+Mammary+Epithelial+Cells+%28NHMECs%29+Exposed+to+Benzopyrenes&rft.au=John%2C+Kaarthik%3BDivi%2C+Rao+L%3BKeshava%2C+Channa%3BWhipkey%2C+Diana+L%3BPoirier%2C+Miriam+C%3BWeston%2C+Ainsley%3BNath%2C+Joginder&rft.aulast=John&rft.aufirst=Kaarthik&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DLC-1 Tumor Suppressor Gene Induces Apoptosis in Human Non-Small Cell Lung Carcinoma Cells Following a Unique Process of Cell Morphological Changes and Protein Nuclear Translocation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007733; 4186962 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yuan, Bao-Zhu AU - Jefferson, Amy M AU - Millecchia, Lyndell AU - Reynolds, Steven H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Non-small cell lung carcinoma KW - Protein transport KW - Apoptosis KW - Tumor suppressor genes KW - Nuclear transport KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=DLC-1+Tumor+Suppressor+Gene+Induces+Apoptosis+in+Human+Non-Small+Cell+Lung+Carcinoma+Cells+Following+a+Unique+Process+of+Cell+Morphological+Changes+and+Protein+Nuclear+Translocation&rft.au=Yuan%2C+Bao-Zhu%3BJefferson%2C+Amy+M%3BMillecchia%2C+Lyndell%3BReynolds%2C+Steven+H&rft.aulast=Yuan&rft.aufirst=Bao-Zhu&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Challenges of Personalized Medicine in Oncology T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007463; 4186685 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Woodcock, Janet Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Regulatory+Challenges+of+Personalized+Medicine+in+Oncology&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNp63 Modulates Activation of Specific NFkB Subunits in Keratinocytes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39997317; 4183479 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - King, Kathryn E AU - Ponnamperuma, Roshini M AU - Weinberg, Wendy C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - NF-^KB protein KW - Keratinocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39997317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=DNp63+Modulates+Activation+of+Specific+NFkB+Subunits+in+Keratinocytes&rft.au=King%2C+Kathryn+E%3BPonnamperuma%2C+Roshini+M%3BWeinberg%2C+Wendy+C&rft.aulast=King&rft.aufirst=Kathryn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of the C->T Polymorphism in DNA-Methyl-Transferase-3B (DNMT 3B) Promoter Correlates with Expression of DNMT 3B in Female Pancreatic Tumor Cells: Modulation of Expression by Indole-3-Carbinol and Gemcitabine T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973863; 4187198 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lyn-Cook, Beverly AU - Haefele, Aaron AU - Word, Beverly AU - Hammons, George J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor cells KW - Indole-3-carbinol KW - Promoters KW - Pancreas KW - Gemcitabine KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Detection+of+the+C-%26gt%3BT+Polymorphism+in+DNA-Methyl-Transferase-3B+%28DNMT+3B%29+Promoter+Correlates+with+Expression+of+DNMT+3B+in+Female+Pancreatic+Tumor+Cells%3A+Modulation+of+Expression+by+Indole-3-Carbinol+and+Gemcitabine&rft.au=Lyn-Cook%2C+Beverly%3BHaefele%2C+Aaron%3BWord%2C+Beverly%3BHammons%2C+George+J&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescence Imaging of Human Pancreatic Cancer Metastasis in Animal Model and Effect of IL-4 Receptor Directed Cytotoxin on Survival of Immunodeficient Mice with Advanced Disease T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967967; 4184720 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Shimamura, Takeshi AU - Kioi, Mitomu AU - Husain, Syed R AU - Puri, Raj K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Animal models KW - Mice KW - Fluorescence KW - Pancreatic cancer KW - Imaging techniques KW - Immunodeficiency KW - Survival KW - Interleukin 4 KW - Cytotoxins KW - Metastases KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Fluorescence+Imaging+of+Human+Pancreatic+Cancer+Metastasis+in+Animal+Model+and+Effect+of+IL-4+Receptor+Directed+Cytotoxin+on+Survival+of+Immunodeficient+Mice+with+Advanced+Disease&rft.au=Shimamura%2C+Takeshi%3BKioi%2C+Mitomu%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Changes in the Tamoxifen-Induced Rat Hepatocarcinogenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967071; 4185126 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pogribny, Igor AU - Tryndyak, Volodymyr AU - Muskhelishvili, Levan AU - Montgomery, Beverly AU - Kovalchuk, Olga AU - Poirier, Lionel A AU - Ross, Sharon A AU - Churchwell, Mona I AU - BelandFrederick, A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Epigenetic+Changes+in+the+Tamoxifen-Induced+Rat+Hepatocarcinogenesis&rft.au=Pogribny%2C+Igor%3BTryndyak%2C+Volodymyr%3BMuskhelishvili%2C+Levan%3BMontgomery%2C+Beverly%3BKovalchuk%2C+Olga%3BPoirier%2C+Lionel+A%3BRoss%2C+Sharon+A%3BChurchwell%2C+Mona+I%3BBelandFrederick%2C+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges to the Promise of Individualized Therapy: Working with the FDA T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39931373; 4181417 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hackett, Joseph L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - FDA KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Challenges+to+the+Promise+of+Individualized+Therapy%3A+Working+with+the+FDA&rft.au=Hackett%2C+Joseph+L&rft.aulast=Hackett&rft.aufirst=Joseph&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perspective on Accelerated Approval of Oncology Drugs T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39930894; 4183295 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dagher, Ramzi N Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Perspective+on+Accelerated+Approval+of+Oncology+Drugs&rft.au=Dagher%2C+Ramzi+N&rft.aulast=Dagher&rft.aufirst=Ramzi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - K-Ras Activity State Alterations Induced by Cholestyramine, Lovastatin, Niacin, and Konjac Mannan in Lung T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39910824; 4182928 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Calvert, Richard J AU - Tepper, Shirley AU - Anderson, Lucy M AU - Kritchevsky, David Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Lovastatin KW - K-Ras protein KW - Mannan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=K-Ras+Activity+State+Alterations+Induced+by+Cholestyramine%2C+Lovastatin%2C+Niacin%2C+and+Konjac+Mannan+in+Lung&rft.au=Calvert%2C+Richard+J%3BTepper%2C+Shirley%3BAnderson%2C+Lucy+M%3BKritchevsky%2C+David&rft.aulast=Calvert&rft.aufirst=Richard&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Statistical Design of Accelerated Approval Studies T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39896009; 4183298 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sridhara, Raji Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Statistical+Design+of+Accelerated+Approval+Studies&rft.au=Sridhara%2C+Raji&rft.aulast=Sridhara&rft.aufirst=Raji&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Management of Toxicity: Approval of UGT1A1 Genetic Test and Irinotecan Label Update T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39887882; 4184592 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rahman, Atiqur AU - Huang, Shiew-Mei AU - Mehta, Mehul U AU - Ramchandani, Roshni AU - Booth, Brian P AU - Pazdur, Richard AU - Lesko, Lawrence J AU - Frueh, Felix Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity testing KW - Irinotecan KW - Bioaccumulation KW - Pollution indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39887882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Management+of+Toxicity%3A+Approval+of+UGT1A1+Genetic+Test+and+Irinotecan+Label+Update&rft.au=Rahman%2C+Atiqur%3BHuang%2C+Shiew-Mei%3BMehta%2C+Mehul+U%3BRamchandani%2C+Roshni%3BBooth%2C+Brian+P%3BPazdur%2C+Richard%3BLesko%2C+Lawrence+J%3BFrueh%2C+Felix&rft.aulast=Rahman&rft.aufirst=Atiqur&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacogenomic Analysis Reveals Determinants of Sensitivity and Resistance to Geldanamycin Analogs: The Role of Membrane Transporters T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39882058; 4187337 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Huang, Ying AU - Blower, Paul E AU - Barbacioru, Catalin AU - Dai, Zunyan AU - Green, Bridgette AU - Wise, Carolyn AU - Lyn-Cook, Beverly D AU - Kadlubar, Fred F AU - Sadee, Wolfgang Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Membranes KW - Geldanamycin KW - Pharmacogenomics KW - Analogs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Pharmacogenomic+Analysis+Reveals+Determinants+of+Sensitivity+and+Resistance+to+Geldanamycin+Analogs%3A+The+Role+of+Membrane+Transporters&rft.au=Huang%2C+Ying%3BBlower%2C+Paul+E%3BBarbacioru%2C+Catalin%3BDai%2C+Zunyan%3BGreen%2C+Bridgette%3BWise%2C+Carolyn%3BLyn-Cook%2C+Beverly+D%3BKadlubar%2C+Fred+F%3BSadee%2C+Wolfgang&rft.aulast=Huang&rft.aufirst=Ying&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Use of tissue-fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers AN - 20864976; 6773199 AB - Gentamicin continues to be one of the most effective antibiotics for the treatment of gram-negative infections. Greater than 90% of the drug is rapidly eliminated from the body in <2 days, however, a small residue remains bound to the kidney cortex tissue for many months. In beef steers, the gentamicin residue is unacceptable and its presence is monitored by the FAST (Fast Antimicrobial Screen Test) applied to the kidney at the time of slaughter. The sensitivity of the FAST to gentamicin in the kidney cortex is reported to be 100 ng/g, therefore, this level of gentamicin defines the acceptable limit of gentamicin drug residue in the bovine kidney. In the present study, three doses of 4 mg/kg gentamicin was administered intramuscularly to eight steers. Gentamicin was allowed to deplete from the kidneys for a range of times from 7 to 10 months. At slaughter the level of gentamicin in the kidney cortex varied from 91 to 193 ng/g, but a total of 160 FAST tests performed on the kidneys were negative. Blood and urine samples were collected at varying times following the last dose of gentamicin. Kidney tissue samples were collected by laparoscopic surgery in the live steers as well as the final sample obtained at slaughter. Plasma levels of gentamicin declined rapidly to nondetectable within 3 days, while measurable urine persisted for 75 days before the concentration of gentamicin declined to levels too low to quantitate by the available liquid chromatography tandem mass spectrometry (LC/MS/MS) technique. An estimated correlation between an extrapolation of urine gentamicin concentration to the corresponding kidney tissue sample suggests a urine to kidney tissue relationship of 1:100. A test system sufficiently sensitive to a urine gentamicin concentration of 1 ng/mL will correlate with the estimated 100 ng/g gentamicin limit of the FAST applied to the fresh kidney of the recently slaughtered bovine. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Chiesa, O A AU - Bredow, J AU - Heller, D AU - Nochetto, C AU - Smith, M AU - Moulton, K AU - Thomas, M AD - Division of Residue Chemistry, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA, ochiesa@cvm.fda.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 99 EP - 106 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 29 IS - 2 SN - 0140-7783, 0140-7783 KW - Microbiology Abstracts B: Bacteriology KW - renal cortex KW - Laparoscopy KW - Antibiotics KW - Infection KW - Mass spectroscopy KW - Gentamicin KW - Blood KW - Plasma levels KW - Liquid chromatography KW - Beef KW - Urine KW - Surgery KW - Kidney KW - Slaughter KW - Drugs KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20864976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=Use+of+tissue-fluid+correlations+to+estimate+gentamicin+residues+in+kidney+tissue+of+Holstein+steers&rft.au=Chiesa%2C+O+A%3BBredow%2C+J%3BHeller%2C+D%3BNochetto%2C+C%3BSmith%2C+M%3BMoulton%2C+K%3BThomas%2C+M&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2006-04-01&rft.volume=29&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fj.1365-2885.2006.00720.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - SuppNotes - Figures, 2; tables, 3. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Laparoscopy; renal cortex; Antibiotics; Infection; Mass spectroscopy; Gentamicin; Blood; Plasma levels; Urine; Beef; Liquid chromatography; Surgery; Kidney; Slaughter; Drugs DO - http://dx.doi.org/10.1111/j.1365-2885.2006.00720.x ER - TY - JOUR T1 - Discovery of Natural Atypical Nonhemolytic Listeria seeligeri Isolates AN - 20241066; 6750716 AB - We found seven Listeria isolates, initially identified as isolates with the Xyl super(+) Rha super(-) biotype of Listeria welshimeri by phenotypic tests, which exhibited discrepant genotypic properties in a well-validated Listeria species identification oligonucleotide microarray. The microarray gives results of these seven isolates being atypical hly-negative L. seeligeri isolates, not L. welshimeri isolates. The aberrant L. seeligeri isolates were D-xylose fermentation positive, L-rhamnose fermentation negative (Xyl super(+) Rha super(-)), and nonhemolytic on blood agar and in the CAMP test with both Staphylococcus aureus (S super(-) reaction) and Rhodococcus equi (R super(-) reaction). All genes of the prfA cluster of L. seeligeri, located in the prs-ldh region, including the orfA2, orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, orfI, orfP, orfB, and orfA genes, were checked by PCR and direct sequencing for evidence of their presence in the atypical isolates. The prs-prfA cluster-ldh region of the L. seeligeri isolates was approximately threefold shorter due to the loss of orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, and orfI. The genetic map order of the cluster genes of all the atypical L. seeligeri isolates was prs-orfA2-orfP-orfB-orfA-ldh, which was comparable to the similar region in L. welshimeri, with the exception of the presence of orfA2. DNA sequencing and phylogenetic analysis of 17 housekeeping genes indicated an L. seeligeri genomic background in all seven of the atypical hly-negative L. seeligeri isolates. Thus, the novel biotype of Xyl super(+) Rha super(-) Hly super(-) L. seeligeri strains can only be distinguished from Xyl super(+) Rha super(-) L. welshimeri strains genotypically, not phenotypically. In contrast, the Rha super(+) Xyl super(+) biotype of L. welshimeri would not present an identification issue. JF - Applied and Environmental Microbiology AU - Volokhov, Dmitriy AU - George, Joseph AU - Anderson, Christine AU - Duvall, Robert E AU - Hitchins, Anthony D AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, Maryland 20895. Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740-3835 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2439 EP - 2448 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 4 SN - 0099-2240, 0099-2240 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Camp test KW - Agar KW - Biotypes KW - Fermentation KW - Phospholipase C KW - L-Rhamnose KW - Oligonucleotides KW - Listeria KW - Listeria seeligeri KW - Blood KW - DNA sequencing KW - Listeria welshimeri KW - Polymerase chain reaction KW - genomics KW - Rhodococcus equi KW - Staphylococcus aureus KW - J 02710:Identification, taxonomy and typing KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Discovery+of+Natural+Atypical+Nonhemolytic+Listeria+seeligeri+Isolates&rft.au=Volokhov%2C+Dmitriy%3BGeorge%2C+Joseph%3BAnderson%2C+Christine%3BDuvall%2C+Robert+E%3BHitchins%2C+Anthony+D&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2006-04-01&rft.volume=72&rft.issue=4&rft.spage=2439&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Camp test; Phylogeny; Agar; Blood; DNA sequencing; Biotypes; Fermentation; Phospholipase C; L-Rhamnose; Polymerase chain reaction; genomics; Oligonucleotides; Listeria seeligeri; Listeria welshimeri; Staphylococcus aureus; Rhodococcus equi; Listeria ER - TY - JOUR T1 - Characterization of a Novel Human Tumor Antigen Interleukin-13 Receptor alpha 2 Chain AN - 20230672; 6810073 AB - The interleukin (IL)-13 receptor alpha 2 (IL-13R alpha 2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13R alpha 2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has not been defined. To investigate the role of IL-13R alpha 2 in tumor immunity, we used D5 melanoma cells stably transfected with the human IL-13R alpha 2 gene (D5 alpha 2) to assess the effect of an IL-13R alpha 2 DNA vaccine in immunocompetent animals. Prophylactic immunization of mice with the IL-13R alpha 2 DNA vaccine resulted in protection against D5 alpha 2 tumor development. In vivo depletion experiments in C57BL/6 and RAG-2 knockout mice indicated that both T and B cells, but not natural killer cells, were required for the tumor protection. In addition, antibody induced by the IL-13R alpha 2 DNA vaccine showed a modest but significant inhibitory effect on D5 alpha 2 cells in vitro, suggesting that the antibody is biologically functional. The IL-13R alpha 2 DNA vaccine also exhibited antitumor activity against established D5 alpha 2 tumors in mice. Histologic analysis of regressing tumors identified infiltration of CD4 super(+) and CD8 super(+) T cells and the expression of CXCL9 chemokine in tumors. Taken together, our results identify the human IL-13R alpha 2 chain as a novel tumor rejection antigen. (Cancer Res 2006; 66(8): 4434-42) JF - Cancer Research AU - Kawakami, Koji AU - Terabe, Masaki AU - Kawakami, Mariko AU - Berzofsky, Jay A AU - Puri, Raj K AD - Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4434 EP - 4442 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 8 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Chemokines KW - Lymphocytes B KW - Natural killer cells KW - Tumors KW - CD8 antigen KW - Immunity KW - Tumor cells KW - Cancer KW - Immunization KW - Melanoma KW - Metastases KW - CD4 antigen KW - Interleukin 13 KW - Antibodies KW - DNA vaccines KW - Antigen (tumor-associated) KW - tumor rejection antigens KW - Lymphocytes T KW - Antitumor activity KW - F 06152:Tumor Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20230672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Characterization+of+a+Novel+Human+Tumor+Antigen+Interleukin-13+Receptor+alpha+2+Chain&rft.au=Kawakami%2C+Koji%3BTerabe%2C+Masaki%3BKawakami%2C+Mariko%3BBerzofsky%2C+Jay+A%3BPuri%2C+Raj+K&rft.aulast=Kawakami&rft.aufirst=Koji&rft.date=2006-04-01&rft.volume=66&rft.issue=8&rft.spage=4434&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemokines; Lymphocytes B; Natural killer cells; Immunity; CD8 antigen; Tumors; Tumor cells; Immunization; Cancer; Melanoma; Metastases; Antibodies; Interleukin 13; CD4 antigen; DNA vaccines; tumor rejection antigens; Antigen (tumor-associated); Lymphocytes T; Antitumor activity ER - TY - BOOK T1 - Acute Respiratory Effects of Smoke Exposure in Wildland Firefighters AN - 20185871; 7157314 AB - Background: Respiratory problems are estimated to affect 5% to 10% of wildland firefighters. The National Institute for Occupational Safety and Health assessed the acute respiratory effects of smoke exposure in 56 members of two National Park Service Interagency "Hotshot" Crews. Methods: We collected questionnaire and spirometry data during two preseason training sessions in May 2004 and May 2005, for 8 days during a wildfire in Alaska in July 2004, 3 days during a wildfire in Wyoming in July 2005, and 8 days during a prescribed fire in Yosemite National Park in October 2005. The most recent observations were used for individuals who fully participated both years. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gaughan, D M AU - Cox-Ganser, J M AU - Kreiss, K AU - Enright, P L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Sustainability Science Abstracts; Health & Safety Science Abstracts KW - USA, Alaska KW - Inhalation KW - wildfire KW - Fires KW - USA, Wyoming KW - firefighter services KW - Training KW - Occupational safety KW - National parks KW - national parks KW - Smoke KW - Respiratory function KW - Occupational exposure KW - M3 1010:Issues in Sustainable Development KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20185871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Sustainability+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gaughan%2C+D+M%3BCox-Ganser%2C+J+M%3BKreiss%2C+K%3BEnright%2C+P+L&rft.aulast=Gaughan&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Acute+Respiratory+Effects+of+Smoke+Exposure+in+Wildland+Firefighters&rft.title=Acute+Respiratory+Effects+of+Smoke+Exposure+in+Wildland+Firefighters&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Molecular identification of Yersinia enterocolitica isolated from pasteurized whole milk using DNA microarray chip hybridization AN - 20075533; 6818740 AB - A DNA microarray chip of four virulence genes and 16S ribosomal DNA gene conserved region among all Gram negative species, including Yersinia, as a positive control was developed and evaluated using 22 Yersinia enterocolitica isolates. Eight different oligonucleotide probes (oligoprobes) with an average size of 22 bp, complementary to the unique sequences of each gene, were designed and immobilized on the surface of chemically modified slides. Multiplex PCR was used to simultaneously amplify DNA target regions of all five genes, and single stranded DNA (ssDNA) samples for microarray analysis were prepared by using a primer extension of amplicons in the presence of one primer of all genes. The presence of genes in Y. enterocolitica was established by hybridization of the fluorescently labeled ssDNA representing different samples of the microarray gene-specific oligoprobes and confirmed by PCR. Results of the study showed specificity of genotyping Y. enterocolitica using multiple microarray-based assays. Final validation of the chip's ability to identify Y. enterocolitica genes from adulterated pasteurized whole milk was confirmed and successful. The limit of chip detection of virulence genes in pasteurized whole milk was found to be 1000 CFU per hybridization. JF - Molecular and Cellular Probes AU - Myers, K M AU - Gaba, J AU - Al-Khaldi, S F AD - Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-517, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA, sufian.al-khaldi@cfsan.fda.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 71 EP - 80 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 20 IS - 2 SN - 0890-8508, 0890-8508 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA microarray KW - Yersinia enterocolitica KW - Multiplex PCR KW - Whole milk KW - Virulence KW - Milk KW - Genotyping KW - Colony-forming cells KW - Probes KW - Polymerase chain reaction KW - Primers KW - DNA microarrays KW - Oligonucleotides KW - W 30910:Imaging KW - J 02710:Identification, taxonomy and typing KW - J 02704:Enumeration KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20075533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Molecular+identification+of+Yersinia+enterocolitica+isolated+from+pasteurized+whole+milk+using+DNA+microarray+chip+hybridization&rft.au=Myers%2C+K+M%3BGaba%2C+J%3BAl-Khaldi%2C+S+F&rft.aulast=Myers&rft.aufirst=K&rft.date=2006-04-01&rft.volume=20&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2005.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Milk; Colony-forming cells; Genotyping; Probes; Polymerase chain reaction; Primers; Oligonucleotides; DNA microarrays; Yersinia enterocolitica DO - http://dx.doi.org/10.1016/j.mcp.2005.09.006 ER - TY - BOOK T1 - Antibacterial, Antifungal, Antiviral, and Anti-spore Bio-Protective Equipment AN - 20011207; 7157287 AB - Broad importance of the research problem: The importance of bio-protective equipment for healthcare workers, emergency responders, and other related personnel cannot be overemphasized; this is the last safeguard protecting the human body from exposure to bio-hazardous agents. The currently used equipment can largely prevent the penetration of biological agents, but it cannot destroy these agents. Studies have shown that a wide range of bio-agents including bacteria, fungi, viruses and spores have strong abilities to survive and grow on the surfaces of bio-protective equipment. Therefore, the equipment could be heavily contaminated and become important sources of cross-contamination. Furthermore,in the case of a leakage or "strike through" of biological agents (which is not uncommon in real uses), the barrier function of the protective equipment would be lost and the users would face great danger. Purpose of the Study: The purpose of this study is to introduce potent antibacterial, antifungal, antiviral and ant-spore functions into bio-protective equipment. The new equipment is expected to be able to significantly improve the occupational safety of healthcare workers, emergency responders, and other related personnel. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Sun, Y AU - Luo, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Leakage KW - Fungi KW - Occupational safety KW - Viruses KW - Airborne microorganisms KW - Protective equipment KW - Medical personnel KW - Personnel KW - Spores KW - Occupational exposure KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20011207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sun%2C+Y%3BLuo%2C+J&rft.aulast=Sun&rft.aufirst=Y&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Antibacterial%2C+Antifungal%2C+Antiviral%2C+and+Anti-spore+Bio-Protective+Equipment&rft.title=Antibacterial%2C+Antifungal%2C+Antiviral%2C+and+Anti-spore+Bio-Protective+Equipment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Triaryl Pyrazoline Compound Inhibits Flavivirus RNA Replication AN - 19999633; 6750067 AB - Triaryl pyrazoline {[5-(4-chloro-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-ph e nyl-methanone} inhibits flavivirus infection in cell culture. The inhibitor was identified through high-throughput screening of a compound library using a luciferase-expressing West Nile (WN) virus infection assay. The compound inhibited an epidemic strain of WN virus without detectable cytotoxicity (a 50% effective concentration of 28 mu M and a compound concentration of greater than or equal to 300 mu M required to reduce 50% cell viability). Besides WN virus, the compound also inhibited other flaviviruses (dengue, yellow fever, and St. Louis encephalitis viruses), an alphavirus (Western equine encephalitis virus), a coronavirus (mouse hepatitis virus), and a rhabdovirus (vesicular stomatitis virus). However, the compound did not suppress an orthomyxovirus (influenza virus) or a retrovirus (human immunodeficiency virus type 1). Mode-of-action analyses in WN virus showed that the compound did not inhibit viral entry or virion assembly but specifically suppressed viral RNA synthesis. To examine the mechanism of inhibition of dengue virus, we developed two replicon systems for dengue type 1 virus: (i) a stable cell line that harbored replicons containing a luciferase reporter and a neomycin phosphotransferase selection marker and (ii) a luciferase-expressing replicon that could differentiate between viral translation and RNA replication. Analyses of the compound in the dengue type 1 virus replicon systems showed that it weakly suppressed viral translation but significantly inhibited viral RNA synthesis. Overall, the results demonstrate that triaryl pyrazoline exerts a broad spectrum of antiflavivirus activity through potent inhibition of viral RNA replication. This novel inhibitor could be developed for potential treatment of flavivirus infection. JF - Antimicrobial Agents & Chemotherapy AU - Puig-Basagoiti, Francesc AU - Tilgner, Mark AU - Forshey, Brett M AU - Philpott, Sean M AU - Espina, Noel G AU - Wentworth, David E AU - Goebel, Scott J AU - Masters, Paul S AU - Falgout, Barry AU - Ren, Ping AU - Ferguson, David M AU - Shi, Pei-Yong AD - Wadsworth Center, New York State Department of Health. Department of Biomedical Sciences, University at Albany, State University of New York, Albany, New York 12208. U.S. Food and Drug Administration, Bethesda, Maryland 20892. Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1320 EP - 1329 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 4 SN - 0066-4804, 0066-4804 KW - HIV-1 KW - Triaryl pyrazolines KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Dengue virus KW - Virions KW - Translation KW - Orthomyxovirus KW - Coronavirus KW - Cell culture KW - Infection KW - Flavivirus KW - Influenza KW - Western equine encephalitis virus KW - Retrovirus KW - Dengue KW - Human immunodeficiency virus 1 KW - Rhabdovirus KW - high-throughput screening KW - Vesicular stomatitis virus KW - Epidemics KW - Replication KW - Transcription KW - Murine hepatitis virus KW - Encephalitis KW - Antimicrobial agents KW - Western equine encephalitis KW - Cytotoxicity KW - Influenza virus KW - Alphavirus KW - neomycin phosphotransferase KW - A 01340:Antibiotics & Antimicrobials KW - V 22100:Antiviral agents KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19999633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Triaryl+Pyrazoline+Compound+Inhibits+Flavivirus+RNA+Replication&rft.au=Puig-Basagoiti%2C+Francesc%3BTilgner%2C+Mark%3BForshey%2C+Brett+M%3BPhilpott%2C+Sean+M%3BEspina%2C+Noel+G%3BWentworth%2C+David+E%3BGoebel%2C+Scott+J%3BMasters%2C+Paul+S%3BFalgout%2C+Barry%3BRen%2C+Ping%3BFerguson%2C+David+M%3BShi%2C+Pei-Yong&rft.aulast=Puig-Basagoiti&rft.aufirst=Francesc&rft.date=2006-04-01&rft.volume=50&rft.issue=4&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Translation; Epidemics; Replication; Transcription; Cell culture; Infection; Encephalitis; Antimicrobial agents; Influenza; Cytotoxicity; Western equine encephalitis; Retrovirus; Dengue; high-throughput screening; neomycin phosphotransferase; Dengue virus; Orthomyxovirus; Western equine encephalitis virus; Influenza virus; Coronavirus; Human immunodeficiency virus 1; Rhabdovirus; Alphavirus; Murine hepatitis virus; Flavivirus; Vesicular stomatitis virus ER - TY - BOOK T1 - Aerosolization of Microbial Contaminants and Fine Particles from Metalworking Fluids AN - 19976346; 7157356 AB - Background: Workers exposed to machining fluid aerosols may have an increased risk in developing a variety of respiratory and skin diseases, such as allergies, asthma, hypersensitivity pneumonitis, and dermatitis. Microbial contamination of water-based MWFs is one of the suspected causes for respiratory diseases but the exposure-response relationship is not well understood. One reason for this knowledge cap is that insufficient information has been available so far on the composition and concentration of airborne microorganisms at metalworking sites. Objective: We have studied the aerosolization of microorganisms and mist with a laboratory-scale set-up, which allows investigating one variable at a time. Using this simulator, we investigated the aerosolization of fine particles, microorganisms, and endotoxin from two types of water-soluble MWFs: semi-synthetic MWF and soluble oil. Field sampling was performed to validate the results obtained in the laboratory. Results: Laboratory experiments showed that hydrophobic microorganisms are easier to aerosolize than hydrophilic ones, and that increasing microorganism size decreased aerosolization. Bacterial contamination increased the aerosolization of fine particles. This effect was more pronounced for semi-synthetic MWF than for soluble oil. The particle size-selective collection revealed that particles below the intact bacterial cell size contained significant concentration of endotoxin. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Reponen, T AU - Wang, H AU - Grinshpun, SA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts; Pollution Abstracts KW - Endotoxins KW - Contamination KW - Airborne microorganisms KW - Hydrophobicity KW - Particulates KW - Respiratory diseases KW - Microbial contamination KW - Metal-working fluids KW - Allergies KW - Oil KW - Hypersensitivity KW - Dose-response effects KW - Cell size KW - Sampling KW - Occupational exposure KW - Dermatitis KW - Aerosols KW - Laboratory testing KW - Asthma KW - Air pollution KW - Skin diseases KW - Microorganisms KW - Contaminants KW - Alveolitis KW - A 01490:Miscellaneous KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19976346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reponen%2C+T%3BWang%2C+H%3BGrinshpun%2C+SA&rft.aulast=Reponen&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Aerosolization+of+Microbial+Contaminants+and+Fine+Particles+from+Metalworking+Fluids&rft.title=Aerosolization+of+Microbial+Contaminants+and+Fine+Particles+from+Metalworking+Fluids&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice AN - 19967490; 6750866 AB - Genistein and daidzein are the main isoflavones in legumes. Equol is an intestinal bacterial metabolite of daidzein. In this study, we evaluated the estrogenic potential of daidzein and synthetic ( plus or minus )-equol to stimulate growth of estrogen-dependent breast cancer (MCF-7) in vitro and in vivo. We hypothesize that estrogenic effects of daidzein and ( plus or minus )-equol could modulate the growth of MCF-7 cells both in vitro and also once implanted into ovariectomized athymic mice. At concentrations between 0.001 and 50 mu M, daidzein and ( plus or minus )-equol stimulated the growth of MCF-7 cells with maximal stimulation at 1 mu M in vitro. To evaluate their effects on the growth of MCF-7 cells implanted in ovariectomized athymic mice, two dietary dose-response studies [daidzein (125, 250, 500 and 1000 p.p.m.) and ( plus or minus )-equol (250, 500 and 1000 p.p.m.)] were conducted. Tumor size and body weight were monitored weekly during the study. At completion of the study, we analyzed cellular proliferation of tumors using immunohistochemical staining (ki-67), pS2 expression in tumors using a real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and total daidzein and ( plus or minus )-equol levels in plasma using liquid chromatography-electrospray tandem mass spectrometry (LC-ES/MS/MS). Dietary daidzein had a slight but significant stimulatory effect on MCF-7 tumor growth in mice. No significant induction of pS2 mRNA (an estrogen-responsive marker) in tumors by dietary daidzein was observed. Total plasma daidzein concentrations in plasma were between 0.25 and 1.52 mu M. Dietary equol treatment (for 37 weeks) did not stimulate MCF-7 tumor growth. There were no statistical differences in tumor size, proliferation and pS2 expression among any treatment groups. Total equol concentrations in plasma were 2.10-3.21 mu M. In conclusion, daidzein and ( plus or minus )-equol have proliferative effects on MCF-7 cell growth in vitro within the concentration range tested. Dietary daidzein had a slight but significant stimulatory effect on tumor growth, whereas ( plus or minus )-equol did not stimulate the growth of estrogen-dependent breast tumor growth in athymic mice, increase the cell proliferation in tumors, or induce an estrogen-responsive pS2 expression. Total daidzein or ( plus or minus )-equol plasma levels in mice fed the isoflavones were in the range that stimulated MCF-7 cell growth in vitro. These results suggest that pharmacokinetic and/or metabolic factors attenuate the estrogenic effects of daidzein and equol in vivo. JF - Carcinogenesis AU - Ju, Young H AU - Fultz, Jodi AU - Allred, Kimberly F AU - Doerge, Daniel R AU - Helferich, William G AD - Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, USA. National Center for Toxicological Research, Jefferson, AR 72079, USA. Present address: 325 Wallace Hall Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Present address: Department of Physiology, University of Kentucky, Lexington, KY 40536, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 856 EP - 863 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 4 SN - 0143-3334, 0143-3334 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Statistics KW - Metabolites KW - Tumors KW - Mass spectroscopy KW - Pharmacokinetics KW - Isoflavones KW - daidzein KW - Plasma levels KW - Body weight KW - isoflavones KW - Presenilin 2 KW - Legumes KW - Carcinogenesis KW - Body size KW - Intestine KW - Breast cancer KW - Ovariectomy KW - Cell proliferation KW - Genistein KW - J 02410:Animal Diseases KW - N 14845:Miscellaneous KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Effects+of+dietary+daidzein+and+its+metabolite%2C+equol%2C+at+physiological+concentrations+on+the+growth+of+estrogen-dependent+human+breast+cancer+%28MCF-7%29+tumors+implanted+in+ovariectomized+athymic+mice&rft.au=Ju%2C+Young+H%3BFultz%2C+Jodi%3BAllred%2C+Kimberly+F%3BDoerge%2C+Daniel+R%3BHelferich%2C+William+G&rft.aulast=Ju&rft.aufirst=Young&rft.date=2006-04-01&rft.volume=27&rft.issue=4&rft.spage=856&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Statistics; Metabolites; Tumors; Isoflavones; Pharmacokinetics; Mass spectroscopy; daidzein; Plasma levels; Body weight; Presenilin 2; isoflavones; Legumes; Carcinogenesis; Intestine; Body size; Breast cancer; Ovariectomy; Cell proliferation; Genistein ER - TY - JOUR T1 - Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation AN - 19960020; 6814586 AB - Despite recent emerging evidence suggesting that cancer stem cells subsist in a variety of tumors, it is not yet fully elucidated whether postnatal stem cells are directly involved in tumorigenesis. We used murine bone marrow-derived mesenchymal stem cells (BMMSCs) as a model to test a hypothesis that tumorigenesis may originate from spontaneous mutation of stem cells. In this study, we demonstrated that murine BMMSCs, after numerous passages, obtained unlimited population doublings and proceeded to a malignant transformation state, resulting in fibrosarcoma formation in vivo. Transformed BMMSCs colonized to multiple organs when delivered systemically through the tail vein. Fibrosarcoma cells formed by transformed BMMSCs contained cancer progenitors, which were capable of generating colony clusters in vitro and fibrosarcoma in vivo by the second administration. The mechanism by which BMMSCs transformed to malignant cells was associated with accumulated chromosomal abnormalities, gradual elevation in telomerase activity, and increased c-myc expression. Moreover, BMMSCs and their transformed counterpart, fibrosarcoma-forming cells, demonstrated different sensitivity to anti-cancer drugs. BMMSCs/fibrosarcoma transformation system may provide an ideal system to elucidate the mechanism of how stem cells become cancer cells and to screen anti-sarcoma drugs. JF - Stem Cells AU - Miura, Masako AU - Miura, Yasuo AU - Padilla-Nash, Hesed M AU - Molinolo, Alfredo A AU - Fu, Baojin AU - Patel, Vyomesh AU - Seo, Byoung-Moo AU - Sonoyama, Wataru AU - Zheng, Jenny J AU - Baker, Carl C AU - Chen, Wanjun AU - Ried, Thomas AU - Shi, Songtao AD - Dental Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1095 EP - 1103 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Transformation KW - Fibrosarcoma KW - Telomerase KW - Tails KW - Tumorigenesis KW - Animal models KW - Bone marrow KW - Cancer KW - Colonies KW - Stem cells KW - Veins KW - Genomic instability KW - Mesenchyme KW - Mutation KW - c-Myc protein KW - G 07470:Cytogenetics & general KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Accumulated+Chromosomal+Instability+in+Murine+Bone+Marrow+Mesenchymal+Stem+Cells+Leads+to+Malignant+Transformation&rft.au=Miura%2C+Masako%3BMiura%2C+Yasuo%3BPadilla-Nash%2C+Hesed+M%3BMolinolo%2C+Alfredo+A%3BFu%2C+Baojin%3BPatel%2C+Vyomesh%3BSeo%2C+Byoung-Moo%3BSonoyama%2C+Wataru%3BZheng%2C+Jenny+J%3BBaker%2C+Carl+C%3BChen%2C+Wanjun%3BRied%2C+Thomas%3BShi%2C+Songtao&rft.aulast=Miura&rft.aufirst=Masako&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Fibrosarcoma; Tails; Telomerase; Tumorigenesis; Bone marrow; Animal models; Cancer; Stem cells; Colonies; Genomic instability; Veins; Mesenchyme; Mutation; c-Myc protein ER - TY - JOUR T1 - Recent Advances in Azo Dye Degrading Enzyme Research AN - 19887244; 8516103 AB - Azo dyes, which are characterized by one or more azo bonds, are a predominant class of colorants used in tattooing, cosmetics, foods, and consumer products. These dyes are mainly metabolized by bacteria to colorless aromatic amines, some of which are carcinogenic, by azoreductases that catalyze a NAD(P)H-dependent reduction. The resulting amines are further degraded aerobically by bacteria. Some bacteria have the ability to degrade azo dyes both aerobically and anaerobically. Plant-degrading white rot fungi can break down azo dyes by utilizing a number of oxidases and peroxidases as well. In yeast, a ferric reductase system participates in the extracellular reduction of azo dyes. Recently, two types of azoreductases have been discovered in bacteria. The first class of azoreductases is monomeric flavin- free enzymes containing a putative NAD(P)H binding motif at their N-termini; the second class is polymeric flavin dependent enzymes which are studied more extensively. Azoreductases from bacteria represent novel families of enzymes with little similarity to other reductases. Dissociation and reconstitution of the flavin dependent azoreductases demonstrate that the non-covalent bound flavin prosthetic group is required for the enzymatic functions. In this review, structures and carcinogenicity of azo colorants, protein structure, enzymatic function, and substrate specificity, as well as application of the azo dyes and azoreductases will be discussed. JF - Current Protein & Peptide Science AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA. Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 101 EP - 111 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 2 SN - 1389-2037, 1389-2037 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Azo dyes KW - Azoreductase KW - Commensal bacteria KW - Environmental microorganisms KW - Biodegradation KW - Aromatic amines KW - Carcinogenicity KW - Peroxidase KW - Food KW - Fungi KW - flavin KW - Enzymes KW - Substrate specificity KW - Cosmetics KW - White rot KW - Protein structure KW - Prosthetic groups KW - amines KW - reductase KW - Dyes KW - Reviews KW - Consumers KW - Aromatics KW - J 02330:Biochemistry KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Protein+%26+Peptide+Science&rft.atitle=Recent+Advances+in+Azo+Dye+Degrading+Enzyme+Research&rft.au=Chen%2C+Huizhong&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2006-04-01&rft.volume=7&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Current+Protein+%26+Peptide+Science&rft.issn=13892037&rft_id=info:doi/10.2174%2F138920306776359786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Azo dyes; Fungi; Food; Peroxidase; flavin; Substrate specificity; Enzymes; Cosmetics; Protein structure; White rot; Prosthetic groups; amines; reductase; Dyes; Carcinogenicity; Reviews; Consumers; Azoreductase; Aromatics DO - http://dx.doi.org/10.2174/138920306776359786 ER - TY - BOOK T1 - Prevalence and Risk Factors for Bloodborne Exposure and Infection in Correctional Healthcare Workers AN - 19858654; 7157292 AB - Objective: To determine prevalence and risk factors for bloodborne exposure and infection in correctional healthcare workers (CHCWs). Design: Cross-sectional confidential questionnaire and serological testing. Setting: Correctional systems in three states. Results: Among 310 participating CHCWs, the rate of percutaneous injury (PI) was 36/100 person years overall and 42/100 for CHCWs with clinical job duties. Most (52%) PIs were not reported. Independent risk factors for experiencing PI included age >45 years (adjusted odds ratio [AOR] 2.41, P5 years previously. Serologic markers of hepatitis B virus (HBV) infection were identified in 31 (10%) individuals and the prevalence of hepatitis C virus (HCV) infection was 2% (n=7). The high HB vaccination rate limited ability to identify risk factors for infection, but HCV infection correlated with community risk factors only. Conclusion: While the wide coverage with HB vaccination and the rate of HCV infection falling within general population estimates is encouraging, the high rate of exposure in CHCWs and the lack of exposure documentation is a concern. Continued efforts to develop interventions to reduce exposures and encourage reporting should be implemented and evaluated in correctional health care settings. These interventions should address infection control barriers unique to the correctional setting. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gershon, R G AU - Mitchell, C S AU - Sherman, M F AU - Felknor, SA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Prisons KW - Inventories KW - vaccines KW - Hepatitis B virus KW - Injuries KW - hepatitis B KW - Infection KW - Vaccination KW - Medical personnel KW - Hepatitis KW - infectious diseases KW - Blood KW - Hepatitis C virus KW - Health care KW - Risk factors KW - Hepatitis B KW - Vaccines KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19858654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gershon%2C+R+G%3BMitchell%2C+C+S%3BSherman%2C+M+F%3BFelknor%2C+SA&rft.aulast=Gershon&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Prevalence+and+Risk+Factors+for+Bloodborne+Exposure+and+Infection+in+Correctional+Healthcare+Workers&rft.title=Prevalence+and+Risk+Factors+for+Bloodborne+Exposure+and+Infection+in+Correctional+Healthcare+Workers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Enhanced transduction of mouse salivary glands with AAV5-based vectors AN - 19853814; 6782987 AB - We previously demonstrated that recombinant adeno-asso-ciated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells in vitro and in vivo. However, it is not known how other rAAV serotypes perform when infused into salivary glands. The capsids of serotypes 4 and 5 are distinct from rAAV2 and from each other, suggesting that they may direct binding and entry into different cell types. In the present study, we investigated the tropisms, transduction efficiencies, and antibody response to AAV vectors based on AAV serotypes 2, 4, and 5. Administration of rAAV2 beta -galactosidase ( beta gal), rAAV4 beta gal, or rAAV5 beta gal to murine submandibular salivary glands by retrograde ductal instillation resulted in efficient transduction of salivary epithelial cells, with AAV4 and AAV5 producing 2.3 and 7.3 times more beta gal activity compared with AAV2. improved transduction with AAV5 was confirmed by QPCR of DNA extracted from glands and immunohisto-chemical staining for transgene expression. Like AAV2, AAV5 primarily transduced striated and intercalated ductal cells. AAV4 transduction was evident in striated, intercalated, and excretory ductal cells, as well as in convoluted granular tubules. In keeping with the encapsulated nature of the salivary gland, the majority of persistent viral genomes were found in the gland and not in other tissues. Neutralizing antibodies (NABs) found in the serum of virus-infused animals were serotype specific and there was no cross-reactivity between serotypes. No NABs were detected in saliva but sialic acid conjugates present in saliva could neutralize AAV4 at low dilutions. Together our data suggest that because of differences in receptor binding and transduction pathways, other serotypes may have improved utility as gene transfer vectors in the salivary gland and these differences could be exploited in gene therapy applications. JF - Gene Therapy AU - Katano, H AU - Kok, M R AU - Cotrim, A P AU - Yamano, S AU - Schmidt, M AU - Afione, S AU - Baum, B J AU - Chiorini, JA AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, US Department of Health and Human Services, NIH 10/1N113, 10 Center Dr, MSC1190, Bethesda, MD 20892, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 594 EP - 601 VL - 13 IS - 7 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Capsids KW - Genomes KW - Epithelial cells KW - Data processing KW - Cross-reactivity KW - Serotypes KW - Gene therapy KW - Tropism KW - Antibody response KW - Salivary gland KW - Adeno-associated virus KW - Expression vectors KW - DNA KW - Saliva KW - Sialic acids KW - Tubules KW - W3 33181:Gene therapy vectors KW - V 22410:Animal Diseases KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19853814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Enhanced+transduction+of+mouse+salivary+glands+with+AAV5-based+vectors&rft.au=Katano%2C+H%3BKok%2C+M+R%3BCotrim%2C+A+P%3BYamano%2C+S%3BSchmidt%2C+M%3BAfione%2C+S%3BBaum%2C+B+J%3BChiorini%2C+JA&rft.aulast=Katano&rft.aufirst=H&rft.date=2006-04-01&rft.volume=13&rft.issue=7&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fsj.gt.3302691 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Capsids; Epithelial cells; Serotypes; Cross-reactivity; Data processing; Gene therapy; Tropism; Antibody response; Salivary gland; Expression vectors; DNA; Saliva; Sialic acids; Tubules; Adeno-associated virus DO - http://dx.doi.org/10.1038/sj.gt.3302691 ER - TY - JOUR T1 - Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral Infection AN - 19831982; 6749068 AB - Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate the risks associated with PERV transmission to human patients by pig tissue xenotransplantation or to study the potential pathogenesis associated with PERV infection. In previous work we isolated two genes encoding functional human PERV receptors and proved that introduction of these into mouse fibroblasts allowed the normally nonpermissive mouse cells to become productively infected (T. A. Ericsson, Y. Takeuchi, C. Templin, G. Quinn, S. F. Farhadian, J. C. Wood, B. A. Oldmixon, K. M. Suling, J. K. Ishii, Y. Kitagawa, T. Miyazawa, D. R. Salomon, R. A. Weiss, and C. Patience, Proc. Natl. Acad. Sci. USA 100:6759-6764, 2003). In the present study we created mice transgenic for human PERV-A receptor 2 (HuPAR-2). After inoculation of transgenic animals with infectious PERV supernatants, viral DNA and RNA were detected at multiple time points, indicating productive replication. This establishes the role of HuPAR-2 in PERV infection in vivo; in addition, these transgenic mice represent a new model for determining the risk of PERV transmission and potential pathogenesis. These mice also create a unique opportunity to study the immune response to PERV infection and test potential therapeutic or preventative modalities. JF - Journal of Virology AU - Martina, Y AU - Marcucci, K T AU - Cherqui, S AU - Szabo, A AU - Drysdale, T AU - Srinivisan, U AU - Wilson, CA AU - Patience, C AU - Salomon AD - Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037. Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892. Biogen Idec, 14 Cambridge Center, Cambridge, Massachusetts 02142 Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 3135 EP - 3146 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 7 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Replication KW - Animal models KW - Infection KW - Transgenic mice KW - Porcine endogenous retrovirus KW - Fibroblasts KW - Retrovirus KW - RNA KW - Inoculation KW - DNA KW - Xenografts KW - Immune response KW - W 30925:Genetic Engineering KW - V 22150:Animal models & experimentally-induced viral infections KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19831982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Mice+Transgenic+for+a+Human+Porcine+Endogenous+Retrovirus+Receptor+Are+Susceptible+to+Productive+Viral+Infection&rft.au=Martina%2C+Y%3BMarcucci%2C+K+T%3BCherqui%2C+S%3BSzabo%2C+A%3BDrysdale%2C+T%3BSrinivisan%2C+U%3BWilson%2C+CA%3BPatience%2C+C%3BSalomon&rft.aulast=Martina&rft.aufirst=Y&rft.date=2006-04-01&rft.volume=80&rft.issue=7&rft.spage=3135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Retrovirus; RNA; Replication; DNA; Inoculation; Animal models; Immune response; Xenografts; Transgenic mice; Infection; Fibroblasts; Porcine endogenous retrovirus ER - TY - JOUR T1 - Characterization of a Soluble Ligand Binding Domain of the NMDA Receptor Regulatory Subunit NR3A AN - 19770089; 6813187 AB - NR3A is expressed widely in the developing CNS of mammals. Coassembly of NR3A with NR1 and NR2 modifies NMDA receptor-mediated responses, reducing calcium permeability and single-channel conductance. The ligand binding properties of NR3A are unknown but shape the role NR3A plays when incorporated into NMDA receptors. Here, a soluble NR3A ligand binding domain (NR3A S1S2) was constructed based on amino acid sequence alignments with other glutamate receptor ion channels and is expressed in Escherichia coli. After purification by affinity, gel filtration, and ion exchange chromatography, NR3A S1S2 behaves as a monomer even at a concentration of 20 mg/ml, as determined by size-exclusion chromatography and dynamic light scattering. NR3A S1S2 has very high affinity for glycine with an apparent dissociation constant (K sub(d)) of 40 nM, 650-fold less than the K sub(d) for NR1. Glutamate, which binds to NR2 subunits, also binds to NR3A, but with very low affinity (K sub(d) = 9.6 mM); in contrast, binding of glutamate to NR1 was not detectable even at a 300 mM concentration. The antagonist binding profiles of NR3A and NR1 also show striking differences. 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX), and its analog CGP78608, bind to NR3A S1S2 with low micromolar affinity, whereas for NR1, the affinity of CGP78608 increases 1000-fold compared with CNQX. Other high-affinity NR1 antagonists also show very weak binding to NR3A. Proteolysis protection experiments reveal that CNQX and CGP78608 bind to and stabilize domain 1 of NR3A S1S2 but increase proteolysis of domain 2, indicating that they produce conformational changes distinct from those induced by glycine and D-serine. JF - Journal of Neuroscience AU - Yao, Yongneng AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4559 EP - 4566 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 17 SN - 0270-6474, 0270-6474 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Proteolysis KW - Central nervous system KW - N-Methyl-D-aspartic acid receptors KW - Receptor mechanisms KW - Glycine KW - Chromatography KW - Conductance KW - Light scattering KW - Glutamic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Calcium permeability KW - Monomers KW - Filtration KW - D-Serine KW - Nervous system KW - Regulatory subunits KW - Ion channels KW - Escherichia coli KW - Purification KW - Ion exchange KW - Amino acid sequence KW - N3 11071:Membranes, receptors, and channels KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Characterization+of+a+Soluble+Ligand+Binding+Domain+of+the+NMDA+Receptor+Regulatory+Subunit+NR3A&rft.au=Yao%2C+Yongneng%3BMayer%2C+Mark+L&rft.aulast=Yao&rft.aufirst=Yongneng&rft.date=2006-04-01&rft.volume=26&rft.issue=17&rft.spage=4559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Central nervous system; N-Methyl-D-aspartic acid receptors; Receptor mechanisms; Conductance; Chromatography; Glycine; Light scattering; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Calcium permeability; Monomers; Nervous system; D-Serine; Filtration; Regulatory subunits; Ion channels; Purification; Ion exchange; Amino acid sequence; Escherichia coli ER - TY - JOUR T1 - Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF- alpha AN - 19637610; 7371147 AB - Enhanced expression of tumor necrosis factor (TNF) - alpha , is associated with the neuropathological effects underlying disease-, trauma- and chemically induced neurodegeneration. Previously, we have shown that deficiency of TNF receptors protects against MPTP-induced striatal dopaminergic neurotoxicity, findings suggestive of a role for TNF- alpha in neurodegeneration. Here, we demonstrate that deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP. MPTP-induced expression of microglia-derived factors, TNF- alpha , MCP-1, and IL-1 alpha , preceded the degeneration of striatal dopaminergic nerve terminals and astrogliosis, as assessed by loss of striatal dopamine and TH, and an increase in striatal GFAP. Pharmacological neuroprotection with the dopamine reuptake inhibitor, nomifensine, abolished striatal dopaminergic neurotoxicity and associated microglial activation. Similarly, in mice lacking TNF receptors, microglial activation was suppressed, findings consistent with a role for TNF- alpha in striatal MPTP neurotoxicity. In the hippocampus, however, TNF receptor-deficient mice showed exacerbated neuronal damage after MPTP, as evidenced by Fluoro Jade-B staining (to identify degenerating neurons) and decreased microtubule-associated protein-2 (MAP-2) immunoreactivity. These effects were not accompanied by microglial activation, but were associated with increased oxidative stress (nitrosylation of tyrosine residues). These findings suggest that TNF- alpha exerts a neurotrophic/neuroprotective effect in hippocampus. The marked differences we observed in the regional density, distribution and/or activity of microglia and microglia-derived factors may influence the region-specific role for this cell type. Taken together, our results are indicative of a region-specific and dual role for TNF- alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus. JF - FASEB Journal AU - Sriram, K AU - Matheson, J M AU - Benkovic, SA AU - Miller, D B AU - Luster, MI AU - O'Callaghan, J P AD - CDC-NIOSH, M/S L-3014, 1095 Willowdale Road, Morgantown, WV 26505, USA, jdo5@cdc.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 670 EP - 682 VL - 20 IS - 6 SN - 0892-6638, 0892-6638 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Monocyte chemoattractant protein 1 KW - Nomifensine KW - Hippocampus KW - MPTP KW - Microtubule-associated protein 2 KW - Interleukin 1 KW - Glial fibrillary acidic protein KW - Brain KW - Tyrosine KW - Neuroprotection KW - Microglia KW - Neurodegeneration KW - Tumor necrosis factor receptors KW - Promoters KW - Dopamine KW - Nerve endings KW - Oxidative stress KW - Immunoreactivity KW - Neurotoxicity KW - Neostriatum KW - Tumor necrosis factor- alpha KW - gliosis KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19637610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=Deficiency+of+TNF+receptors+suppresses+microglial+activation+and+alters+the+susceptibility+of+brain+regions+to+MPTP-induced+neurotoxicity%3A+role+of+TNF-+alpha&rft.au=Sriram%2C+K%3BMatheson%2C+J+M%3BBenkovic%2C+SA%3BMiller%2C+D+B%3BLuster%2C+MI%3BO%27Callaghan%2C+J+P&rft.aulast=Sriram&rft.aufirst=K&rft.date=2006-04-01&rft.volume=20&rft.issue=6&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Nomifensine; Monocyte chemoattractant protein 1; Microtubule-associated protein 2; MPTP; Hippocampus; Interleukin 1; Brain; Glial fibrillary acidic protein; Tyrosine; Neuroprotection; Microglia; Neurodegeneration; Tumor necrosis factor receptors; Promoters; Nerve endings; Dopamine; Oxidative stress; Neostriatum; Neurotoxicity; Immunoreactivity; Tumor necrosis factor- alpha; gliosis ER - TY - JOUR T1 - HIV Transmission in Correctional Facility AN - 19590288; 7307574 AB - Acute retroviral syndrome developed in an inmate in a detention center after he had intercourse with 2 HIV-infected inmates. Correctional facilities house a disproportionate number of HIV-infected persons, and most do not provide inmates with condoms. Correctional healthcare providers should be familiar with primary HIV infection and acute retroviral syndrome. JF - Emerging Infectious Diseases AU - Macher, A AU - Kibble, D AU - Wheeler, D AD - US Public Health Service (retired), Bethesda, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 VL - 12 IS - 4 SN - 1080-6040, 1080-6040 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - prisons KW - Condoms KW - infectious diseases KW - Human immunodeficiency virus KW - condoms KW - Residential areas KW - Infection KW - Sexual behavior KW - sexually transmitted diseases KW - Disease transmission KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19590288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=HIV+Transmission+in+Correctional+Facility&rft.au=Macher%2C+A%3BKibble%2C+D%3BWheeler%2C+D&rft.aulast=Macher&rft.aufirst=A&rft.date=2006-04-01&rft.volume=12&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Condoms; Infection; Disease transmission; prisons; infectious diseases; Residential areas; condoms; Sexual behavior; sexually transmitted diseases; Human immunodeficiency virus ER - TY - JOUR T1 - In Vitro Cytotoxicity of Nonpolar Constituents from Different Parts of Kava Plant (Piper methysticum) AN - 19578505; 7281826 AB - Kava (Piper methysticum), a perennial shrub native to the South Pacific islands, has been used to relieve anxiety. Recently, several cases of severe hepatotoxicity have been reported from the consumption of dietary supplements containing kava. It is unclear whether the kava constituents, kavalactones, are responsible for the associated hepatotoxicity. To investigate the key components responsible for the liver toxicity, bioassay-guided fractionation was carried out in this study. Kava roots, leaves, and stem peelings were extracted with methanol, and the resulting residues were subjected to partition with a different polarity of solvents (hexane, ethyl acetate, n-butanol, and water) for evaluation of their cytotoxicity on HepG2 cells based on the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and lactate dehydrogenase and aspartate aminotransferase enzyme leakage assays. Organic solvent fractions displayed a much stronger cytotoxicity than water fractions for all parts of kava. The hexane fraction of the root exhibited stronger cytotoxic effects than fractions of root extracted with other solvents or extracts from the other parts of kava. Further investigations using bioassay-directed isolation and analysis of the hexane fraction indicated that the compound responsible for the cytotoxicity was flavokavain B. The identity of the compound was confirmed by super(1)H and super(13)C NMR and MS techniques. JF - Journal of Agricultural and Food Chemistry AU - Jhoo, J-W AU - Freeman, J P AU - Heinze, T M AU - Moody, J D AU - Schnackenberg, L K AU - Beger, R D AU - Dragull, K AU - Tang, C-S AU - Ang, CYW AD - National Center for Toxicological Research, U.S. Food and Drug Administration, HFT-230, 3900 NCTR Road, Jefferson, Arkansas 72079, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 3157 EP - 3162 VL - 54 IS - 8 SN - 0021-8561, 0021-8561 KW - Toxicology Abstracts KW - Shrubs KW - Leakage KW - Anxiety KW - Aspartate aminotransferase KW - Methanol KW - Leaves KW - Solvents KW - Enzymes KW - Roots KW - Hexane KW - Toxicity KW - bromides KW - hepatotoxicity KW - L-Lactate dehydrogenase KW - Cytotoxicity KW - Dietary supplements KW - Piper methysticum KW - Ethyl acetate KW - Liver KW - Polarity KW - N.M.R. KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19578505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=In+Vitro+Cytotoxicity+of+Nonpolar+Constituents+from+Different+Parts+of+Kava+Plant+%28Piper+methysticum%29&rft.au=Jhoo%2C+J-W%3BFreeman%2C+J+P%3BHeinze%2C+T+M%3BMoody%2C+J+D%3BSchnackenberg%2C+L+K%3BBeger%2C+R+D%3BDragull%2C+K%3BTang%2C+C-S%3BAng%2C+CYW&rft.aulast=Jhoo&rft.aufirst=J-W&rft.date=2006-04-01&rft.volume=54&rft.issue=8&rft.spage=3157&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf051853j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Shrubs; Leakage; Anxiety; Aspartate aminotransferase; Methanol; Solvents; Leaves; Roots; Enzymes; Hexane; Toxicity; bromides; hepatotoxicity; L-Lactate dehydrogenase; Cytotoxicity; Dietary supplements; Ethyl acetate; Liver; N.M.R.; Polarity; Piper methysticum DO - http://dx.doi.org/10.1021/jf051853j ER - TY - JOUR T1 - Determination of Usnic Acid in Lichen Toxic to Elk by Liquid Chromatography with Ultraviolet and Tandem Mass Spectrometry Detection AN - 19575020; 7281135 AB - Usnic acid is unambiguously confirmed by tandem mass spectrometry (MS/MS) in tumbleweed shield lichen, Xanthoparmelia chlorochroa. The lichen contains 2% usnic acid by liquid chromatography with UV quantification at 282 nm. The UV linear range for usnic acid quantification is from its 4 ng limit of detection to 2 mu g injected. UV signal saturation is recognized by distortion of the usnic acid UV spectrum. Positive ion electro spray-tandem mass spectrometry offers no similar means to recognize quantification data recorded above the linear range of electrospray. Electrospray ionization capacity and matrix effects limit the reliability of tandem mass spectrometry quantification. The combination of UV quantification and MS confirmation provides a reliable analytical method for measuring usnic acid levels in plant material. JF - Journal of Agricultural and Food Chemistry AU - Roach, JAG AU - Musser, S M AU - Morehouse, K AU - Woo, JYJ AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2484 EP - 2490 VL - 54 IS - 7 SN - 0021-8561, 0021-8561 KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Lichens KW - U.V. radiation KW - Data processing KW - Liquid chromatography KW - Xanthoparmelia chlorochroa KW - Usnic acid KW - Ionization KW - Mass spectroscopy KW - K 03300:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19575020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Determination+of+Usnic+Acid+in+Lichen+Toxic+to+Elk+by+Liquid+Chromatography+with+Ultraviolet+and+Tandem+Mass+Spectrometry+Detection&rft.au=Roach%2C+JAG%3BMusser%2C+S+M%3BMorehouse%2C+K%3BWoo%2C+JYJ&rft.aulast=Roach&rft.aufirst=JAG&rft.date=2006-04-01&rft.volume=54&rft.issue=7&rft.spage=2484&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf052767m LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; U.V. radiation; Lichens; Liquid chromatography; Usnic acid; Ionization; Mass spectroscopy; Xanthoparmelia chlorochroa DO - http://dx.doi.org/10.1021/jf052767m ER - TY - JOUR T1 - An Efficient Method for the Derivation of Mouse Embryonic Stem Cells AN - 19441470; 6814598 AB - Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers; however, the process of ESC derivation is often very inefficient and requires high specialization, training, and expertise. To circumvent these limitations, we aimed to develop a simple and efficient protocol based on the use of commercially available products. Here, we present an optimized protocol that we successfully applied to derive ESCs from several knockout mouse strains (Wnt-1, Wnt-5a, Lrp6, and parkin) with 50%-75% efficiency. The methodology is based on the use of mouse embryonic fibroblast feeders, knockout serum replacement (SR), and minimal handling of the blastocyst. In this protocol, all centrifugation steps (as well as the use of trypsin inhibitor) were avoided and replaced by an ESC medium containing fetal calf serum (FCS) after the trypsinizations. We define the potential advantages and disadvantages of using SR and FCS in individual steps of the protocol. We also characterize the ESCs for the expression of ESC markers by immunohistochemistry, Western blot, and a stem cell focused microarray. In summary, we provide a simplified and improved protocol to derive mESCs that can be useful for laboratories aiming to isolate transgenic mESCs for the first time. JF - Stem Cells AU - Bryja, Vitezlav AU - Bonilla, Sonia AU - Cajanek, Lukas AU - Parish, Clare L AU - Schwartz, Catherine M AU - Luo, Yongquan AU - Rao, Mahendra S AU - Arenas, Ernest AD - Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 844 EP - 849 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Western blotting KW - parkin protein KW - Trypsin KW - Fetal calf serum KW - Specialization KW - Fibroblasts KW - Centrifugation KW - blastocysts KW - Stem cells KW - Embryo cells KW - Embryos KW - Immunohistochemistry KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19441470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=An+Efficient+Method+for+the+Derivation+of+Mouse+Embryonic+Stem+Cells&rft.au=Bryja%2C+Vitezlav%3BBonilla%2C+Sonia%3BCajanek%2C+Lukas%3BParish%2C+Clare+L%3BSchwartz%2C+Catherine+M%3BLuo%2C+Yongquan%3BRao%2C+Mahendra+S%3BArenas%2C+Ernest&rft.aulast=Bryja&rft.aufirst=Vitezlav&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stem cells; Embryo cells; Fibroblasts; parkin protein; Embryos; Trypsin; blastocysts; Immunohistochemistry; Western blotting; Specialization; Centrifugation; Fetal calf serum ER - TY - BOOK T1 - Farm Safety Day Camps - Reducing Children's Exposures to Farm Hazards by Influencing Parents' Attitudes Toward Farm Safety AN - 19440665; 7157261 AB - Agriculture still ranks among the four most hazardous occupations in the United States. As many as 32,000 non-fatal and 100 fatal farm injuries occur each year to children. Whether or not a child performs farm tasks, children are exposed to farm hazards by being part of the farm environment. This three-year study examined changes in knowledge, attitude and behavior toward farm risk based on a cohort of children who attended a farm safety camp and their parents. While some literature supports safety knowledge improvements for children who attend safety day camps, less is known about the potential effect of the camps on parents of these children. Parents are in better positions to protect children from harm, thus this study examined what effects, if any, the camps had on parental behavior toward farm safety. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Reed, D B AU - Claunch, D T AU - Rayens, M K AU - Westneat, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - Hazards KW - USA KW - Farms KW - Behavior KW - Injuries KW - Occupational safety KW - Human factors KW - Children KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reed%2C+D+B%3BClaunch%2C+D+T%3BRayens%2C+M+K%3BWestneat%2C+S&rft.aulast=Reed&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Farm+Safety+Day+Camps+-+Reducing+Children%27s+Exposures+to+Farm+Hazards+by+Influencing+Parents%27+Attitudes+Toward+Farm+Safety&rft.title=Farm+Safety+Day+Camps+-+Reducing+Children%27s+Exposures+to+Farm+Hazards+by+Influencing+Parents%27+Attitudes+Toward+Farm+Safety&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - What's Good for Your Eyes? Results From a Field Evaluation of Two Interventions AN - 19440625; 7157349 AB - Amid all of the well-deserved concern about upper extremity musculoskeletal disorders there is little said about the greater prevalence of visual symptoms among office workers. It is estimated visual symptoms cost at least 15 billion dollars and are simple to prevent. However, preventing them is not limited to corrected eyeglasses and lighting. Some workstation characteristics also play a role in visual health while computing. However, few office ergonomics intervention studies address visual symptoms, incorporate comprehensive interventions to impact them and provide sufficient follow-up needed to determine sustainability of effect. Two non-randomized field trials were implemented at public and private sector worksites for the purpose of evaluating the effects of two office ergonomics interventions (a highly adjustable chair and an office ergonomics training) in reducing visual symptoms. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Chaumont-Menendez, C K AU - Amick, BC III AU - Robertson, M M AU - Harrist, R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Training KW - Vision KW - Lighting KW - Ergonomics KW - working conditions KW - musculoskeletal system KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chaumont-Menendez%2C+C+K%3BAmick%2C+BC+III%3BRobertson%2C+M+M%3BHarrist%2C+R&rft.aulast=Chaumont-Menendez&rft.aufirst=C&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=What%27s+Good+for+Your+Eyes%3F+Results+From+a+Field+Evaluation+of+Two+Interventions&rft.title=What%27s+Good+for+Your+Eyes%3F+Results+From+a+Field+Evaluation+of+Two+Interventions&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - HELD'S Hand-Transmitted Vibration Program - From R&D to Practice AN - 19440518; 7157362 AB - Powered hand tools such as chipping hammers, grinders, chainsaws, rock drills, road breakers, and riveters are widely used in several industries such as foundries, automobile manufacturing, forestry, construction, mining, and bridge construction. Hand-arm vibration syndrome (HAVS) is one of the major diseases among more than one million U.S. workers exposed to hand-transmitted vibration (HTV), The most well-known component of HAVS is termed as vibration-induced white finger (VWF). Although HAVS has been studied for more than 80 years, the mechanisms of the syndrome are not sufficiently understood. It is still inconvenient, expensive, and technically difficult to accurately measure tool vibration and to assess related exposure factors such as applied forces and postures. The diagnosis of the disease still mainly depends on subjective questionnaires. Many aspects of current risk assessment methods have not been validated. Further studies on HTV exposure and health effects are required. In responding to these needs, a research and development program has been gradually established in the Health Effects Laboratory Division (HELD) of NIOSH. This presentation provides a brief outline of the program's status and its major achievements. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dong, R AU - Wu, J AU - Welcome, D AU - Brumfield, A AU - McDowell, T AU - Wirth, O AU - Krajnak, K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - USA KW - Vibration KW - Foundries KW - Automotive industry KW - hand-arm vibration syndrome KW - Highways KW - Occupational exposure KW - hand tools KW - Forestry KW - posture KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+R%3BWu%2C+J%3BWelcome%2C+D%3BBrumfield%2C+A%3BMcDowell%2C+T%3BWirth%2C+O%3BKrajnak%2C+K&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=HELD%27S+Hand-Transmitted+Vibration+Program+-+From+R%26D+to+Practice&rft.title=HELD%27S+Hand-Transmitted+Vibration+Program+-+From+R%26D+to+Practice&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Prevalence of Recent Skin Examinations in U.S. Worker Groups: The National Health Interview Survey (NHIS) AN - 19439485; 7157311 AB - Objectives: Research has demonstrated that even among U.S. workers with access to medical care, most healthcare providers do not evaluate occupational exposures and their potential impact on the iealth of U.S. workers. Substantial evidence has shown a link between ultraviolet (UV) light exposure (both occupational and recreational) and various forms of skin cancer. Furthermore, regular skin examination can serve as a preventive health message, as well as a method of detecting early skin cancers for which removal can be curative. This study explored the prevalence of reported skin examination among U.S. workers with access to medical care, particularly among occupations with high occupational UV exposure. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - LeBlanc, W AU - Fleming, LE AU - Lee, D AU - Chung-Bridges, K AU - Christ, S L AU - Cuban, A AU - Arheart, K AU - Pitman, T Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - Skin KW - Occupational exposure KW - Cancer KW - Medical personnel KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=LeBlanc%2C+W%3BFleming%2C+LE%3BLee%2C+D%3BChung-Bridges%2C+K%3BChrist%2C+S+L%3BCuban%2C+A%3BArheart%2C+K%3BPitman%2C+T&rft.aulast=LeBlanc&rft.aufirst=W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Prevalence+of+Recent+Skin+Examinations+in+U.S.+Worker+Groups%3A+The+National+Health+Interview+Survey+%28NHIS%29&rft.title=The+Prevalence+of+Recent+Skin+Examinations+in+U.S.+Worker+Groups%3A+The+National+Health+Interview+Survey+%28NHIS%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Array-based proteomics: mapping of protein circuitries for diagnostics, prognostics, and therapy guidance in cancer AN - 19438747; 6708574 AB - The human proteome, due to the enormity of post-translational permutations that result in large numbers of isoforms, is much more complex than the genome and alterations in cancer can occur in ways that are not predictable by translational analysis alone. Proteomic analysis therefore represents a more direct way of investigating disease at the individual patient level. Furthermore, since most novel therapeutic targets are proteins, proteomic analysis potentially has a central role in patient care. At the same time, it is becoming clear that mapping entire networks rather than individual markers may be necessary for robust diagnostics as well as tailoring of therapy. Consequently, there is a need for high-throughput multiplexed proteomic techniques, with the capability of scanning multiple cases and analysing large numbers of endpoints. New types of protein arrays combined with advanced bioinformatics are currently being used to identify molecular signatures of individual tumours based on protein pathways and signalling cascades. It is envisaged that analysing the cellular "circuitry" of ongoing molecular networks will become a powerful clinical tool in patient management. JF - Journal of Pathology AU - Gulmann, C AU - Sheehan, Km AU - Kay, Ew AU - Petricoin III, Ef AD - NCI-FDA Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA, cgulmann@rcsi.ie Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 595 EP - 606 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 208 IS - 5 SN - 0022-3417, 0022-3417 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Translation KW - Peptide mapping KW - Tumors KW - Cancer KW - Computer programs KW - Scanning KW - Post-translation KW - Protein arrays KW - Bioinformatics KW - proteomics KW - Signal transduction KW - Gene mapping KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pathology&rft.atitle=Array-based+proteomics%3A+mapping+of+protein+circuitries+for+diagnostics%2C+prognostics%2C+and+therapy+guidance+in+cancer&rft.au=Gulmann%2C+C%3BSheehan%2C+Km%3BKay%2C+Ew%3BPetricoin+III%2C+Ef&rft.aulast=Gulmann&rft.aufirst=C&rft.date=2006-04-01&rft.volume=208&rft.issue=5&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pathology&rft.issn=00223417&rft_id=info:doi/10.1002%2Fpath.1958 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; Computer programs; Cancer; Gene mapping; Post-translation; Bioinformatics; Translation; Peptide mapping; Scanning; Signal transduction; Genomes; Tumors; Protein arrays DO - http://dx.doi.org/10.1002/path.1958 ER - TY - BOOK T1 - Evaluation of Emergency Service Vehicle Occupant Safety AN - 19393519; 7157380 AB - Broad Importance of the Research Problem: Working in the patient compartment of an ambulance in transit exposes emergency medical service (EMS) personnel to a high-risk of crash-related injury or death on every call. All occupants of ambulance patient compartments are at a 5-fold higher risk of suffering fatal crash-related injuries than the front seat ambulance occupants. Ambulance drivers and front seat passengers are protected from vehicle crash-related injuries by occupant protection systems required by Federal Motor Vehicle Safety Standards (FMVSS). However, similar protection for the patient compartment occupants is not addressed by FMVSS and research related to crash protection for these occupants is sparse. A key contributor to the increased risk among EMS staff in the patient compartment is lack of use of available lap belts or other occupant restraint systems. Seat belts currently provided in ambulances do not allow the mobility that EMS workers need to care for patients. As a result, EMS workers routinely work unrestrained in the patient compartment. Purpose or Objectives of the Study: This project seeks to prevent work-related EMS vehicle crash injuries to emergency service workers in ground ambulance patient compartments. This objective will be accomplished through the development of mobile occupant restraint systems that allow EMS personnel the mobility to provide appropriate patient care while simultaneously providing a level of crash protection similar to that available for front seat occupants. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Moore, PH Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Accidents KW - Injuries KW - Mobility KW - Motor vehicles KW - Occupational safety KW - Protective equipment KW - emergency medical services KW - seat belts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Moore%2C+PH&rft.aulast=Moore&rft.aufirst=PH&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+Emergency+Service+Vehicle+Occupant+Safety&rft.title=Evaluation+of+Emergency+Service+Vehicle+Occupant+Safety&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Clothes-Cleaning Booth Enables More Effective Removal of Dust from Workers' Clothing AN - 19393474; 7157373 AB - A quick, safe, and effective process has been developed that allows workers to clean their dust laden work clothing periodically throughout the day. Contaminated work clothing has been a known major contributor to increased employee respirable dust exposure for many years. This newly designed process is relatively inexpensive and can be easily installed at any operation to allow workers to clean their clothing without exposing the worker, the work environment, or co-workers to elevated respirable dust levels. The clothes cleaning process uses an air-spray manifold to blow dust from a worker's clothing in an enclosed booth. Since the booth is under negative pressure, no dust escapes to contaminate the work environment and or other workers. The worker performing the cleaning process is required to wear a half-mask fit-tested respirator, hearing protection, and full seal goggles. Dust samples taken inside the respirator of test personnel performing the clothes cleaning process showed minimal to no respirable dust exposure. During field testing, the clothes cleaning process was 10 times faster (taking less than 20 seconds) and was approximately 50 percent more effective than either the federally approved method of vacuuming or the most commonly used method of using a single air hose. The National Institute for Occupational Safety and Health developed this new process under a cooperative research effort with Unimin Corporation. This clothes cleaning process has tremendous applicability to any industry where workers' clothing become contaminated with any type of dust or product. Current research is looking to the development of a more mobile stand alone unit that does not require a baghouse. Results of this research effort will be disseminated through workshops with industry organizations such as the National Stone, Sand and Gravel Association and Industrial Minerals Association-North America, publications in industry trade journals, and conference presentations. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Pollock, DE AU - Cecala, AB Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Conferences KW - Sand KW - Occupational safety KW - Air pollution control KW - Baghouses KW - Pollution control equipment KW - Respirators KW - Cleaning process KW - Protective equipment KW - Occupational exposure KW - Dust KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pollock%2C+DE%3BCecala%2C+AB&rft.aulast=Pollock&rft.aufirst=DE&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Clothes-Cleaning+Booth+Enables+More+Effective+Removal+of+Dust+from+Workers%27+Clothing&rft.title=Clothes-Cleaning+Booth+Enables+More+Effective+Removal+of+Dust+from+Workers%27+Clothing&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Seasonal Influences on Low Back Pain AN - 19393438; 7157361 AB - Background: Low Back Pain (LBP) is extraordinarily common, reportedly affecting 75-80% of the population (Andersson). Back claims represent 16% of total workers compensation claims, but a disproportionate 33% of total claim costs (Snook 1982; Webster and Snook 1994). Studies of LBP and/or LBP-associated disability have suggested risk factors including job physical factors, increasing age, a prior history of LBP, gender, smoking, physical fitness, psychosocial factors, and depression (Andersson 1997; Frymoyer 1989; Garg and Moore 1992, Schneider et al. 2005). To our knowledge, seasonal patterns of occurrence of LBP have not been previously reported. Methods: Data were analyzed from a large multi-center occupational prospective cohort study (n=742) of 23 manufacturing plants from Utah, Wisconsin and Texas. All participants underwent a detailed questionnaire, structured interview, and 2 standardized physical examinations at baseline enrollment. Monthly follow up evaluations are performed to assess the development of cases of LBP, including using structured interviews on all participants, and standardized physical examinations on new incident cases of LBP. Outcome measures for LBP were assessed including using a 0-10/10 pain scale rating, pain plus use of medications (over-the-counter or prescription), and pain scale plus any other reported treatment. Results: Monthly period prevalence of LBP with pain scale >3/10 was approximately doubled during the months of August (12%), September (13%), and October (13%) compared with all other months (monthly mean of 6.7%). Incident cases of LBP with pain scale >3/10 were greatest in the months of May (4.7%), October (4.6%), and November (4.3%), and least in the months of June (1.9%), and July (1.7%). Relative Risk for incidence of LBP with pain scale >3/10 was 2.8 from May, the highest month to July, the lowest (reference group) month. In comparing markers of severity, there is an apparent lag in time for reported markers of severity from pain scale >3/10,to pain scale >3/10 plus medications, to pain scale >3/10 plus any other treatment. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Wood, E W AU - Hegmann, K T AU - Garg, A AU - Thiese, M AU - Oostema, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Utah KW - workers' compensation KW - Historical account KW - disabilities KW - low back pain KW - USA, Wisconsin KW - depression KW - Smoking KW - Sulfur dioxide KW - Gender KW - USA, Texas KW - Seasonal variations KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wood%2C+E+W%3BHegmann%2C+K+T%3BGarg%2C+A%3BThiese%2C+M%3BOostema%2C+S&rft.aulast=Wood&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seasonal+Influences+on+Low+Back+Pain&rft.title=Seasonal+Influences+on+Low+Back+Pain&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Quantifying the Effects of Precision on Muscle Loading of the Upper Extremity During a Highly-Repetitive Hand Transfer Task AN - 19393406; 7157345 AB - Introduction: Musculoskeletal disorders of the upper limb are common among semi-automated occupational hand transfer tasks. Some of these tasks that are seen in retail trades, manufacturing, and production assemblyl, have precision requirements that could potentially increase muscle loading. While a few studies have examined the effect of precision on musculoskeletal loading, no studies have looked at this effect in a cyclical pick and place task. Objective: Our aim is to examine the effects of the precision requirement of a repetitive hand transfer task on the upper extremity musculature loading in a laboratory setting. Results: A repeated measures design was utilized to analyze loading for each muscle. This study found that precision resulted in an increased static loading in forearm muscles (ECR, ECU, EDI, and FDS) (p<0.001). Precision task resulted in a 0.6 to 1% MVC increase in muscle loading compared to the non-precision condition. This finding was not observed for the shoulder muscles (UTR, SUP, INF) and one forearm muscle (BRA). In addition, precision placement was perceived to be more difficult than non-precision (p<0.05) based on a self-report questionnaire. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Escorpizo, R S AU - Moore, A E Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Man-machine interactions KW - Working conditions KW - Ergonomics KW - musculoskeletal system KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Escorpizo%2C+R+S%3BMoore%2C+A+E&rft.aulast=Escorpizo&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Quantifying+the+Effects+of+Precision+on+Muscle+Loading+of+the+Upper+Extremity+During+a+Highly-Repetitive+Hand+Transfer+Task&rft.title=Quantifying+the+Effects+of+Precision+on+Muscle+Loading+of+the+Upper+Extremity+During+a+Highly-Repetitive+Hand+Transfer+Task&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Intervention Research in Auto Body Repair and Refinishing Industry: The SMASH Study AN - 19393367; 7157320 AB - The auto body repair and refinishing industry is composed of small family-owned businesses that employ 168,000 to 205,000 workers nationwide. Workers in this industry are exposed to a variety of respiratory and dermal chemicals including isocyanates and organic solvents that can potentially cause occupational asthma, skin diseases and other health problems. Little is known about the effectiveness of exposure control strategies in the industry. The purpose of this study was to implement an intervention program that included educational training, engineering control, administrative changes and behavioral modifications, and to evaluate the effectiveness of each intervention component. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Liu, Y AU - Stowe, M H AU - Sparer, JA AU - Bello, D AU - Cartmel, B AU - Ibrahim, K AU - Fleming, C AU - Collin-Hansen, I AU - Daly, C AU - Youngs, F AU - Woskie AU - Cullen, M R AU - Redlich, CA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Skin KW - Training KW - Automotive industry KW - Solvents KW - Asthma KW - Respiratory diseases KW - Isocyanates KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Liu%2C+Y%3BStowe%2C+M+H%3BSparer%2C+JA%3BBello%2C+D%3BCartmel%2C+B%3BIbrahim%2C+K%3BFleming%2C+C%3BCollin-Hansen%2C+I%3BDaly%2C+C%3BYoungs%2C+F%3BWoskie%3BCullen%2C+M+R%3BRedlich%2C+CA&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Intervention+Research+in+Auto+Body+Repair+and+Refinishing+Industry%3A+The+SMASH+Study&rft.title=Intervention+Research+in+Auto+Body+Repair+and+Refinishing+Industry%3A+The+SMASH+Study&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Administrative Delay and Secondary Disability Following Acute Occupational Low Back Injury AN - 19393325; 7157299 AB - Background and Significance: Occupational low back injury is a pervasive disorder and extensive research has failed to explain a wide variation in outcomes. The purpose of this study is to identify whether a component of the administrative system not studied before, the practice of delaying claim acceptance, has a significant influence on injured worker disability. Methods: The data are 1993 - 2000 claim files provided by the California Workers' Compensation Institute, and estimated to include approximately 50% of all claims for low back injury filed in California during that period. Cases with at least one day of temporary disability paid were selected for the analysis (N=32,584). Logistic regression predicted the influence of administrative delays to claim acceptance on whether a case would become chronic (took more than 91 days of temporary disability) controlling for individual, economic, diagnostic severity and physician experience variables. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Sinnott, P L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - disabilities KW - Injuries KW - Economics KW - USA, California KW - Low back pain KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sinnott%2C+P+L&rft.aulast=Sinnott&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Administrative+Delay+and+Secondary+Disability+Following+Acute+Occupational+Low+Back+Injury&rft.title=Administrative+Delay+and+Secondary+Disability+Following+Acute+Occupational+Low+Back+Injury&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Association of Overtime Work Hours with Ambulatory Blood Pressure Among Female Nurses AN - 19393285; 7157286 AB - Background: A stressful organization of work has been associated with a variety of common illnesses, including cardiovascular disease (CVD), psychological disorders and musculoskeletal disorders. CVD presents a major public health burden because it is the leading cause of morbidity and mortality for both men and women. Previous studies have shown associations between work stressors, such as long work hours and job strain (high demand-low control work), CVD and elevated blood pressure in men, but few studies have included women. Objectives: To study the association between overtime work hours and ambulatory blood pressure (AmBP) among female nurses and nurse aides. Methods: The sample consists of 97 female nurses and nurse aides participating in the Work Site Blood Pressure Study, a prospective cohort study, in 1995 and 2000. The nurses and aides wore ambulatory blood pressure monitors for a 24-hour period, including a work shift. Overtime work hours were obtained from hospital records. Regression models controlled for shift worked, hours worked on shift, job physical exertion, age, race, education, body mass index, smoking, alcohol, and marital status. Results: (a) Significant positive associations with overtime worked on the day the monitor was worn were found for work systolic and diastolic blood pressure in 2000. For every additional hour worked over eight hours, there was an increase of 2.3 mmHg in work systolic blood pressure (p=0.083) and 2.1 mmHg in work diastolic blood pressure (p=0.024). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Paik, J AU - Landsbergis, P AU - Gurnitz, K AU - Schnall, P AU - Pickering, T AU - Schwartz, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Alcohol KW - Mortality KW - Education KW - shift work KW - nursing KW - Blood pressure KW - Medical personnel KW - musculoskeletal system KW - Morbidity KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Paik%2C+J%3BLandsbergis%2C+P%3BGurnitz%2C+K%3BSchnall%2C+P%3BPickering%2C+T%3BSchwartz%2C+J&rft.aulast=Paik&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Association+of+Overtime+Work+Hours+with+Ambulatory+Blood+Pressure+Among+Female+Nurses&rft.title=The+Association+of+Overtime+Work+Hours+with+Ambulatory+Blood+Pressure+Among+Female+Nurses&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Health and Safety Problems of Older RNs Employed in Hospital Settings AN - 19393244; 7157283 AB - Background: The nursing profession is experiencing an unprecedented aging of its workforce, with the average age of a practicing nurse being 44.5 years. This aging is contributing to a serious nursing shortage, which is especially acute in hospital settings. If we are to retain older nurses it is imperative that information about their health and problems concerns be identified. Study Purpose: The purpose of this study was to determine the relationships between demographic variables, job satisfaction, physical and mental health, and job related injuries and health problems of nurses over the age of 50 employed in hospital settings. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Letvak, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Occupational safety KW - nursing KW - Medical personnel KW - Working conditions KW - Hospitals KW - Occupational health KW - aging KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Letvak%2C+S&rft.aulast=Letvak&rft.aufirst=S&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+and+Safety+Problems+of+Older+RNs+Employed+in+Hospital+Settings&rft.title=Health+and+Safety+Problems+of+Older+RNs+Employed+in+Hospital+Settings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Changing the Child Labor Laws for Agriculture: Impact on Injury AN - 19393175; 7157259 AB - Background: Agriculture is the most hazardous industry in the United States for youth workers with a risk for fatal injury that is three to four times that of youth workers in other occupational settings. The child labor laws are intended to protect working youth from the most dangerous jobs. However, children who work on their parents' farms, where the preponderance of these fatal injuries occur, are exempt from the child labor laws. Purpose: The purpose of this study was to review existing cases of traumatic pediatric farm injury and: 1) estimate the proportion of work-related injuries that could potentially be prevented by removing the family farm exemption from the Federal Child Labor Laws, Hazardous Occupations Order for Agriculture (Hazardous Orders); and 2) estimate the proportion of work-related injuries that could potentially be prevented if the age standard for the Hazardous Orders was changed from 16 to 18 years. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Marlenga, B AU - Berg, R L AU - Linneman, J G AU - Brison, R J AU - Pickett, W Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - Mortality KW - USA KW - Injuries KW - farms KW - Reviews KW - Occupational safety KW - Children KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Marlenga%2C+B%3BBerg%2C+R+L%3BLinneman%2C+J+G%3BBrison%2C+R+J%3BPickett%2C+W&rft.aulast=Marlenga&rft.aufirst=B&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Changing+the+Child+Labor+Laws+for+Agriculture%3A+Impact+on+Injury&rft.title=Changing+the+Child+Labor+Laws+for+Agriculture%3A+Impact+on+Injury&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Use of Agricultural Pesticides and Prostate Cancer Risk in the Agricultural Health Study Cohort And Future Plans For Molecular Studies AN - 19393144; 7157239 AB - The role of specific agricultural chemicals in relation to prostate cancer risk and other cancers has not been firmly established due to lack of precise exposure data in previous studies. We comprehensively examined the relationship between 50 common agricultural pesticides and prostate cancer incidence at two points in time (i.e., 2003 and 2005) in a prospective cohort study of 55,332 male applicators from Iowa and North Carolina (the Agricultural Health Study) without prior history of prostate cancer. In both periods of time, a significant excess risk of prostate cancer was observed. Farmers and commercial pesticide applicators had an SIR for prostate cancer of 1.23 (1.18-1.33). Significant exposure-response relationships and/or interaction odds ratio between specific pesticides (butylate, chlorpyrifos, coumaphos, fonofos, phorate, and pyrethrin) among those with a family history of prostate cancer but not among those without a family history of prostate cancer risk were observed, confirming earlier observations. These pesticide-family history interactions suggest gene-environment interactions, but alternative explanations related to clustering of occupational exposures are also possible. A nested case-control study of selected metabolic and DNA repair gene polymorphisms and several biomarkers of genetic and epigenetic damage is planned to clarify the mechanisms that may be responsible for the observed association in our cohort analysis. Specifically, we will assess whether markers of oxidative stress, inflammatory response, genetic and epigenetic damage is observed more frequently in highly exposed subjects compared to those with low exposure over a working lifetime. Histological and molecular tumor tissue characteristics among high and low exposed cases will also be compared. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Alavanja, M AU - Coble, J AU - Beane-Freeman, L AU - Rusiecki, J AU - Bonner, M AU - Mahajan, R AU - Dosemeci, M AU - Samanic, C AU - Lubin, J AU - Lynch, C AU - Knott, C AU - Moore, L AU - Hayes, R AU - Hoppin, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - Bioindicators KW - USA, North Carolina KW - Historical account KW - Tissues KW - Stress KW - Agrochemicals KW - Cancer KW - Chlorpyrifos KW - USA, Iowa KW - Pesticides KW - DNA KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Alavanja%2C+M%3BCoble%2C+J%3BBeane-Freeman%2C+L%3BRusiecki%2C+J%3BBonner%2C+M%3BMahajan%2C+R%3BDosemeci%2C+M%3BSamanic%2C+C%3BLubin%2C+J%3BLynch%2C+C%3BKnott%2C+C%3BMoore%2C+L%3BHayes%2C+R%3BHoppin%2C+J&rft.aulast=Alavanja&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+Agricultural+Pesticides+and+Prostate+Cancer+Risk+in+the+Agricultural+Health+Study+Cohort+And+Future+Plans+For+Molecular+Studies&rft.title=Use+of+Agricultural+Pesticides+and+Prostate+Cancer+Risk+in+the+Agricultural+Health+Study+Cohort+And+Future+Plans+For+Molecular+Studies&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Noise Level Measures in a Large Metropolitan Subway System AN - 19392930; 7157390 AB - Purpose/Problem: Noise induced hearing loss (NIHL), the single most common occupational health problem in industrial societies, is prevalent in heavy machinery, transportation, textiles, utilities, chemicals, fabricated metals, lumber, rubber, and coal industries. In particular, given the rate of increasing world wide urbanization, noise associated with mass transit is of concern, not only because of the vast ridership potentially at risk of noise exposure, but because excessive noise levels have been documented for various forms of mass transit. Subways, in particular, may be associated with excessive levels, especially since high levels of noise have been associated with railroads. Importantly, almost no information is available on noise exposure in subway system environments. In the U.S., there are 14 Mass Transit Systems, with over 350,000 subway workers that provide service to over 33 million riders weekly. As part of a large subway noise assessment study, we recently conducted a pilot study on noise levels in a large metropolitan subway system. Methods: Using a digital sound level meter (Quest 1200, A-level type I), levels were measured as follows: at platform level with (1) subway trains approaching the station, (2) subway trains leaving the station and, (3) express trains passing the platform. Measurements were also taken inside subway cars while trains were approaching the station, when express trains were passing the station, and at bus stops at street level. Conclusion: These data indicate that excessive levels of noise may occur on platforms in the subway, as well as inside the train, and at bus stops. The impact of subway noise exposure on NIHL, prevalence of NIHL in both workers and passengers, and the effect of noise exposure on other health outcomes remains to be determined. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gershon, R G AU - Barrera, M AU - Akram, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - subways KW - Health & Safety Science Abstracts; Pollution Abstracts KW - USA KW - Transportation KW - Urbanization KW - Machinery KW - Noise levels KW - Hearing loss KW - Mining KW - Occupational exposure KW - Utilities KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gershon%2C+R+G%3BBarrera%2C+M%3BAkram%2C+M&rft.aulast=Gershon&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Noise+Level+Measures+in+a+Large+Metropolitan+Subway+System&rft.title=Noise+Level+Measures+in+a+Large+Metropolitan+Subway+System&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Injury and Fatalities in the Mining Workplace: Comparing the United States with Other Mining Countries AN - 19392895; 7157366 AB - This paper compares published mining statistics on injuries and fatalities for the United States and several mining countries where mining plays a significant role in the economic well being of the country. The authors examine similarities and differences between the United States experience and those of countries such as Canada, South Africa, Russia, and Sweden. The focus of discussion is the identification of sometimes hidden clues that help pinpoint the actual injury and fatality rates of the non-US mining countries. It is well known that mining is one of the most dangerous occupations in the Unites States; this paper will document how dangerous mining is in other major mining countries worldwide. The document will identify the technical needs for valid injury statistics and for injury prevention of countries outside of the United States and will give an indication of injury trends in countries where no statistics are available to improve occupational health and safety outcomes. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Brady, T M AU - Bise, C AU - Fowler, C J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - Occupational safety KW - USA KW - Canada KW - Economics KW - prevention KW - Russia KW - South Africa KW - Mining KW - Sweden KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brady%2C+T+M%3BBise%2C+C%3BFowler%2C+C+J&rft.aulast=Brady&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Injury+and+Fatalities+in+the+Mining+Workplace%3A+Comparing+the+United+States+with+Other+Mining+Countries&rft.title=Injury+and+Fatalities+in+the+Mining+Workplace%3A+Comparing+the+United+States+with+Other+Mining+Countries&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Cross-Sectional Study of Auto Body Workers Exposed to Diisocyanates: Respiratory and Dermal Exposures Contribute to Immune Response AN - 19392763; 7157319 AB - Broad Importance of the Research: Diisocyanates are potent sensitizing agents and a common cause of occupational asthma in industrialized countries. However, the health and immunologic effects of diisocyanates under current working conditions and risk factors remain poorly defined. Although respiratory exposure has been shown to induce asthma, the role of dermal exposure remains unclear. Purpose and Methods: A cross-sectional epidemiologic study of 262 body shop workers from 36 shops, Survey of Painters and Repairers of Autobodies by Yale (SPRAY), was performed to characterize diisocyanate exposures and their effects on body shop workers, using questionnaires, physiologic and immunologic assessment of the workers. Individual respiratory exposure was estimated based upon total reactive diisocyanante concentration from air sampling and personal worker activity diaries. Dermal exposure was modeled on frequency of positive skin and surface wipe samples and use of personal protective equipment recorded in worker diaries. Multiple linear regression was employed to determine the contribution of respiratory and dermal exposure estimates to the natural log of HDI-specific IgG level. Other parameters entered in the models included race, gender, respiratory symptoms, atopy, HDI-specific IgE level and job category. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Stowe, M H AU - Wisnewski, A V AU - Sparer, J AU - Liu, Y AU - Woskie AU - Redlich, CA AU - Cullen, M R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - diisocyanates KW - Health & Safety Science Abstracts KW - Skin KW - Sprays KW - Gender KW - Air sampling KW - Asthma KW - Respiratory diseases KW - Immune response KW - Protective equipment KW - Occupational exposure KW - working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stowe%2C+M+H%3BWisnewski%2C+A+V%3BSparer%2C+J%3BLiu%2C+Y%3BWoskie%3BRedlich%2C+CA%3BCullen%2C+M+R&rft.aulast=Stowe&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Cross-Sectional+Study+of+Auto+Body+Workers+Exposed+to+Diisocyanates%3A+Respiratory+and+Dermal+Exposures+Contribute+to+Immune+Response&rft.title=Cross-Sectional+Study+of+Auto+Body+Workers+Exposed+to+Diisocyanates%3A+Respiratory+and+Dermal+Exposures+Contribute+to+Immune+Response&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Social/Economic Impact of Injury/Illness in Career Roofers AN - 19392688; 7157272 AB - As the U.S. population ages, public policy needs to address ways to keep these workers employed. In order to look at the interaction of age and injury on social and economic factors, we have enrolled 989 actively working roofers in a longitudinal study. We will present results of the baseline survey. The baseline interview included questions on: (1) serious medical and musculoskeletal conditions in the past two years, (2) missed work and job accommodations related to these conditions, (3) frequency and duration of musculoskeletal symptoms, and (4) functional status and economic status. Preliminary results show that 69% percent of respondents had experienced at least one target medical or musculoskeletal condition in the previous two years. The vast majority of musculoskeletal conditions were linked to work-related injuries. Nearly one-third (31%) of all respondents reported missing time from work in the prior two years due to a target medical condition or MSD. Fourteen percent of workers with a condition of any type indicated a limitation in three or more work activities, compared to only 4% of respondents with no condition; workers with both medical and musculoskeletal conditions had the highest levels of impairment overall. Seventeen percent (17%) of roofers an MSD and a medical condition felt they could not take care of their families "like they used to" often or almost always, as opposed to 2.4% of those without a condition. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Welch, L S AU - Hunting, K L AU - Entzel, P Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - Injuries KW - Economics KW - Occupational safety KW - Socioeconomics KW - musculoskeletal system KW - Construction industry KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Welch%2C+L+S%3BHunting%2C+K+L%3BEntzel%2C+P&rft.aulast=Welch&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Social%2FEconomic+Impact+of+Injury%2FIllness+in+Career+Roofers&rft.title=Social%2FEconomic+Impact+of+Injury%2FIllness+in+Career+Roofers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Field Evaluation of a Continuous Passive Lumbar Motion System Among Operators of Earthmoving Equipment AN - 19392659; 7157376 AB - Operating heavy mobile construction equipment is often associated with elevated rates of low back discomfort. However, few formal studies have evaluated interventions that may reduce low back discomfort among these workers. The objective of this study was to determine the effectiveness of a continuous passive lumbar motion system (CPLMS), which is an additional lumbar seat support that can cyclically inflate and deflate, in reducing low back discomfort among operators of heavy earth-moving equipment. This was a quasi-experimental intervention study with multiple observations in which body part discomfort surveys were collected from an intervention and a control group during normal working days. The intervention group also completed a CPLMS preference survey after completing use of the CPLMS for 646 hours. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Jorgensen, MJ AU - Viswanathan, M AU - Kittusamy, N K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Machinery KW - Man-machine interactions KW - Ergonomics KW - Working conditions KW - Construction industry KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jorgensen%2C+MJ%3BViswanathan%2C+M%3BKittusamy%2C+N+K&rft.aulast=Jorgensen&rft.aufirst=MJ&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Field+Evaluation+of+a+Continuous+Passive+Lumbar+Motion+System+Among+Operators+of+Earthmoving+Equipment&rft.title=Field+Evaluation+of+a+Continuous+Passive+Lumbar+Motion+System+Among+Operators+of+Earthmoving+Equipment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Safety and Health Training in a Diverse Construction Workforce AN - 19392655; 7157270 AB - Overall, mortality rates for Hispanic workers are higher than for all U.S. workers, although this excess mortality occurs exclusively among foreign-born Hispanic workers, who were one-third more likely to die on the job than U.S. workers as a whole, while fatal occupational injury rates for U.S-born Hispanic workers were virtually identical to all U.S. workers from 1995 - 2000. Construction work consistently ranks among the three industry sectors with the highest rates of fatal occupational injury, and accounts for the greatest number of deaths. Falls from heights are the leading cause of death among construction workers. The purpose of this study is to characterize baseline knowledge, attitudes, behaviors and experiences of apprentices and journeymen in a construction union prior to participation in an OSHA 10 hour course that uses a standardized training program. Specific questions targeted fall hazards. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Jorgensen, E AU - Sokas, R K AU - Nickels, L AU - Gittleman, J AU - Trahan, C AU - Gao, W AU - Beam, C Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Federal regulations KW - Training KW - Occupational safety KW - safety regulations KW - Ethnic groups KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jorgensen%2C+E%3BSokas%2C+R+K%3BNickels%2C+L%3BGittleman%2C+J%3BTrahan%2C+C%3BGao%2C+W%3BBeam%2C+C&rft.aulast=Jorgensen&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Safety+and+Health+Training+in+a+Diverse+Construction+Workforce&rft.title=Safety+and+Health+Training+in+a+Diverse+Construction+Workforce&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Occupational Vibration Alters Neuromuscular Control in the Low Back AN - 19392626; 7157342 AB - Low back disorders are a NORA priority research agenda area. A NIOSH review of epidemiologic evidence for work-related musculoskeletal disorders has identified vibration and particularly whole body vibration as a risk factor for low back injury. Vibration has been associated with a higher incidence of low back disorders in occupations such as pilots, tractor drivers and heavy equipment operators. While research on vibration transmissibility in the low back is extensive, there is still little understanding of the mechanism by which the vibration may lead to injury. The purpose of this research has been to investigate how vibration alters neuromotor control of the low back in order to better understand a potential mechanism for vibration-induced low back injury. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Wilson, SE AU - Li, L AU - Arashanapalli, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Back injuries KW - Vibration KW - Reviews KW - Occupational exposure KW - musculoskeletal system KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wilson%2C+SE%3BLi%2C+L%3BArashanapalli%2C+M&rft.aulast=Wilson&rft.aufirst=SE&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Vibration+Alters+Neuromuscular+Control+in+the+Low+Back&rft.title=Occupational+Vibration+Alters+Neuromuscular+Control+in+the+Low+Back&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Video-based Safety Intervention for West Virginia Loggers - A Success Story AN - 19392600; 7157256 AB - Importance of the Research Problem: Logging is one of the most dangerous industries in the U.S. with timber cutting and logging occupations identified as having extraordinarily high lifetime fatality risk and significantly higher costs of occupational injury and illness. The 2000-2004 logging fatality rate was significantly higher in West Virginia (386.5 per 100,000) compared to the national rate (154.9). Innovative intervention approaches must be integrated with training in order to provide timely and useful information to make workers more aware of workplace safety. Objective: As a result of field investigations conducted by the WV Fatality and Assessment and Control Evaluation (FACE) Program and allied projects with the West Virginia University Division of Forestry and Appalachian Hardwood Center, a Logger Intervention Research Project was undertaken to develop a safety video to be used in WV Division of Forestry (DOF) required logger training classes. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Helmkamp, J C AU - Lundstrom, W J AU - Goldcamp, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Training KW - hardwoods KW - Occupational safety KW - logging KW - cuttings KW - USA, West Virginia KW - Forestry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Helmkamp%2C+J+C%3BLundstrom%2C+W+J%3BGoldcamp%2C+J&rft.aulast=Helmkamp&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Video-based+Safety+Intervention+for+West+Virginia+Loggers+-+A+Success+Story&rft.title=Video-based+Safety+Intervention+for+West+Virginia+Loggers+-+A+Success+Story&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Mechanisms of Repetitive Strain Injury in an Aging Model AN - 19392597; 7157334 AB - There are approximately 700,000 lost time incidents per year in the United States construction, mining, agriculture and manufacturing sectors that are due to musculoskeletal overexertion and repetitive strain injury. In addition, credible epidemiological evidence suggests a higher incidence of pain, injury, and lost time from work in jobs that require high levels of physical exposure. Of additional concern, the 55-64 year old demographic is now the fastest growing sector of the labor force in the United States. It is projected by 2006 that 20% of the labor force will be comprised of workers over the age of 55. However, a research gap exists regarding soft tissue injury mechanics and the effect of aging on injury susceptibility and adaptation to repetitive physical exposures. Thus, we propose to conduct studies that characterize the quantitative dose-response of skeletal muscle due to repetitive mechanical exposures, particularly in an aging model via functional, physiological, and molecular changes. Goal: The goal of this research is to investigate the conditions which increase susceptibility to occupationally-related repetitive motion injuries and to identify how those conditions are altered by aging. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Cutlip, R G AU - Geronilla, K B AU - Baker, BA AU - Mercer, R R AU - Hollander, M AU - Alway, SE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Tissues KW - USA KW - Injuries KW - Dose-response effects KW - overuse injuries KW - Physiology KW - pain KW - musculoskeletal system KW - aging KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cutlip%2C+R+G%3BGeronilla%2C+K+B%3BBaker%2C+BA%3BMercer%2C+R+R%3BHollander%2C+M%3BAlway%2C+SE&rft.aulast=Cutlip&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Mechanisms+of+Repetitive+Strain+Injury+in+an+Aging+Model&rft.title=Mechanisms+of+Repetitive+Strain+Injury+in+an+Aging+Model&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Understanding the Philosophical, Organizational, and Educational Role of Workers' Centers for Developing and Sustaining Programs on Workplace Health and Safety AN - 19392576; 7157332 AB - The phenomenon of immigrant and low wage workers' centers, whose mission it is to organize workers to improve the working conditions of low wage immigrant workers, is increasing in North America. These workers face significant occupational safety hazards due to language barriers, economic necessity, and fear of deportation. Immigrant workers are at risk because of the nature of the work they do, lack of accountability of the employers and lack of knowledge about their rights. The goal of this project was to understand the educational role the workers' centers play in supporting workers' efforts to improve their work environments and increase access to occupational health information and services in a large urban center. The project seeks to increase and sustain the exchange of information and resources for preventing work related injuries and illnesses at and between the workers' centers. Specific research objectives were to 1) understand educational philosophy of workers' center staff, worker leaders or volunteers at 4 worker centers; 2) document methods of identifying workplace exposures and actions for reducing exposure; 3) explore potential intervention strategies for implementation through the worker centers; and 4) describe a framework for increasing access to occupational health information and services. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Nickels, LA AU - Zanoni, J AU - Remington, N AU - Lippert, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - North America KW - Education KW - Injuries KW - immigrants KW - Economics KW - Occupational safety KW - accountability KW - working conditions KW - Occupational health KW - Urban areas KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Nickels%2C+LA%3BZanoni%2C+J%3BRemington%2C+N%3BLippert%2C+J&rft.aulast=Nickels&rft.aufirst=LA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Understanding+the+Philosophical%2C+Organizational%2C+and+Educational+Role+of+Workers%27+Centers+for+Developing+and+Sustaining+Programs+on+Workplace+Health+and+Safety&rft.title=Understanding+the+Philosophical%2C+Organizational%2C+and+Educational+Role+of+Workers%27+Centers+for+Developing+and+Sustaining+Programs+on+Workplace+Health+and+Safety&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Aging Farm Workforce: Work, Organization, Health, and Social Dimensions AN - 19392534; 7157246 AB - The average age of the nation's workforce is 38, but the average age of its farmers is 55. Half of America's farms are operated by persons age 55 and over; 17% are operated by persons over age 70. Despite the rapid aging of the agricultural worker, little is known about their work, work organization, or why they remain in this hazardous occupation. There are no guidelines on farm practices for senior aged farmers. The purpose of this study is to provide data that can be used to develop interventions to optimize healthy and safe working conditions for older farmers and provide a better understanding of what motivates them to remain in their vocation. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Reed, D B AU - Rayens, M K AU - Westneat, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - Farms KW - Occupational safety KW - Volatile organic compounds KW - working conditions KW - aging KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reed%2C+D+B%3BRayens%2C+M+K%3BWestneat%2C+S&rft.aulast=Reed&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Aging+Farm+Workforce%3A+Work%2C+Organization%2C+Health%2C+and+Social+Dimensions&rft.title=The+Aging+Farm+Workforce%3A+Work%2C+Organization%2C+Health%2C+and+Social+Dimensions&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Nature of Injury Data in the BLS Annual Survey Seriously Underestimate the Medical Burden of Work Injuries AN - 19392532; 7157295 AB - Background: The BLS Annual Survey is the current source of national and state data on work injuries. Nature of injury is generally coded from a lay narrative by a lay coder using a quasi-medical taxonomy that requires that the case be coded to the most serious injury, if possible. There have been no published comparisons of the BLS taxonomy with the ICD-9-CM clinical diagnosis taxonomy at the state or national level. Study Objectives: To compare nature of injury data from the nation and Great Lakes states with diagnoses accepted for payment by the Bureau of Workers Compensation in Ohio, where by statute the BWC is the exclusive provider of workers' compensation insurance for about 70% of the state workforce, with the exception of those employers who qualify to self-insure. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Oleinick, A AU - Gandra, C R AU - Simon, C AU - Werner, R A Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - Injuries KW - Occupational safety KW - Economics KW - USA, Ohio KW - Insurance KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Oleinick%2C+A%3BGandra%2C+C+R%3BSimon%2C+C%3BWerner%2C+R+A&rft.aulast=Oleinick&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Nature+of+Injury+Data+in+the+BLS+Annual+Survey+Seriously+Underestimate+the+Medical+Burden+of+Work+Injuries&rft.title=Nature+of+Injury+Data+in+the+BLS+Annual+Survey+Seriously+Underestimate+the+Medical+Burden+of+Work+Injuries&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Duration of Time on Shift Prior to Accidental Blood or Body Fluid Exposure for Housestaff, Nurses and Technicians AN - 19392492; 7157285 AB - Shiftwork has been found to be associated with an increased rate of errors and accidents among health Care Workers (HCWs), but the effect of shiftwork on accidental blood and body fluid exposure (BBFE) sustained by HCWs has not been well characterized. Shiftwork is an occupational stressor, and has been linked to various social, psychological, and medical problems. Shift work has also been shown to lead to fatigue and disruption of the circadian clock. Housestaff and nurses routinely perform shiftwork, working extended hours and performing work outside of typical daytime hours. The objectives of this study are to determine if the duration of time on shift prior to accidental BBFE is similar for housestaff, nurses and technicians, and to compare the proportion of housestaff and nurses who sustain BBFEs. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Green-McKenzie, J AU - Shofer, F Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Blood KW - Accidents KW - shift work KW - Health care KW - Psychology KW - Occupational safety KW - circadian rhythms KW - nursing KW - Medical personnel KW - Occupational exposure KW - working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Green-McKenzie%2C+J%3BShofer%2C+F&rft.aulast=Green-McKenzie&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Duration+of+Time+on+Shift+Prior+to+Accidental+Blood+or+Body+Fluid+Exposure+for+Housestaff%2C+Nurses+and+Technicians&rft.title=Duration+of+Time+on+Shift+Prior+to+Accidental+Blood+or+Body+Fluid+Exposure+for+Housestaff%2C+Nurses+and+Technicians&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Ventilation Strategies for Confined-Space, On-Farm Manure Storages AN - 19392435; 7157244 AB - There are many reports of farmers and farm workers succumbing to the noxious gases in confined-space, on-farm manure storages. Often, multiple deaths occur when family members or friends attempt to rescue the first to succumb to the noxious gases. There is a need to develop engineering standards for the design and installation of ventilation systems to remove noxious gases from such storages prior to entry. The overall objective of the reported research is to develop guidelines and standards to reduce risks associated with entry into confined on-farm manure storage facilities. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Manbeck, H B AU - Murphy, D J AU - Zhao, J AU - Pesce, E P Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Storage KW - Agriculture KW - Confined spaces KW - Mortality KW - Farms KW - Manure KW - Gases KW - Animal wastes KW - Ventilation KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Manbeck%2C+H+B%3BMurphy%2C+D+J%3BZhao%2C+J%3BPesce%2C+E+P&rft.aulast=Manbeck&rft.aufirst=H&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ventilation+Strategies+for+Confined-Space%2C+On-Farm+Manure+Storages&rft.title=Ventilation+Strategies+for+Confined-Space%2C+On-Farm+Manure+Storages&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Violence in the Home Visiting Workplace AN - 19392394; 7157382 AB - Importance: Workplace violence is recognized as a significant hazard in the healthcare sector but has not been studied extensively in visiting health care workers. These workers are potentially exposed to violence from clients, household members, and communities without the safety services of a "fixed" workplace. The limited data suggest that they experience risk factors including client characteristics, location, working alone, and work schedule. The prevalence of verbal violence may be as high as 37% and physical violence 19.9%. (Schulte, 1995; Barling, 2001). Homicides have also been reported. Purpose: Develop new measures for the study of workplace violence in the home visiting healthcare workplace using the NIOSH Organization of Work framework. Methods: The study was a mixed method cross-sectional design using focus groups, expert content reviewers, cognitive interviews, and a self-administered survey of home visiting health workers at four home health programs (n=130). Three new scales were evaluated for evidence of reliability and validity using Cronbach's alpha, item analysis, CFA, and hypothesis testing. Results: Over 60% (61.5%) of the sample reported being verbally abused in the last year. Just over 10% reported being assaulted in their home health career. The Home Visiting Risk Scale (HVRS) and the Employer Violence Prevention Scale (EVPS) demonstrated evidence for acceptable reliability and preliminary validity. Six hypotheses were supported. The HVRS was significantly and positively associated with violence and psychological job demands and different for those who made a safety decision in the past 12 months; the EVPS was significantly and positively associated with social support and staff perception of the OSHA Violence Prevention elements, and negatively correlated to violence. Furthermore the data demonstrate a dose-response relationship between home visit risk and verbal, physical, and total violence. Logistic regression controlling for job type, caseload and for-profit status further supported the validity of the risk measure and the employer role measure. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - McPhaul, K M AU - Soeken, K AU - Johnson, J V AU - Lipscomb, JA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Federal regulations KW - homicide KW - Health care KW - Perception KW - Occupational safety KW - Residential areas KW - prevention KW - safety regulations KW - Violence KW - working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McPhaul%2C+K+M%3BSoeken%2C+K%3BJohnson%2C+J+V%3BLipscomb%2C+JA&rft.aulast=McPhaul&rft.aufirst=K&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Violence+in+the+Home+Visiting+Workplace&rft.title=Violence+in+the+Home+Visiting+Workplace&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Reducing Rock Fall Injuries to Coal Miners Using Roof Screen AN - 19392365; 7157369 AB - Over 500 coal miners are injured every year from the fall of rocks averaging 30 in x 18 in x 4 in. These rocks are falling between roof supports or before roof bolts can be installed. 61% of these injuries occur in the working face shortly after the coal has been mined. Severe crushing injuries and lacerations are occurring to roof bolters and continuous mining machine operators because of their high exposure to newly undercut roof rock. Research has shown dramatic reductions in injury with the use of welded steel screen to cover the roof. NIOSH is actively promoting the use of steel screen as the "gold standard' in providing protection from rock fall. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Molinda, G M AU - Mark, C AU - Gallagher, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Prevention KW - Injuries KW - Falls KW - Occupational safety KW - Coal KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Molinda%2C+G+M%3BMark%2C+C%3BGallagher%2C+S&rft.aulast=Molinda&rft.aufirst=G&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Reducing+Rock+Fall+Injuries+to+Coal+Miners+Using+Roof+Screen&rft.title=Reducing+Rock+Fall+Injuries+to+Coal+Miners+Using+Roof+Screen&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Community and Workplace-Based Training Program for Occupational Medicine AN - 19392319; 7157352 AB - We have developed and evaluated a unique community and workplace based residency-training program to train specialist in Occupational and Environmental Medicine (OEM). The program addresses the serious national shortage of physicians in OEM by focusing on additional skill development in physicians who are already in practice, but lack the special knowledge and skills to be effective in this field. Beyond basic clinical or internship training, specialist training in OEM requires two additional years, one year in obtaining an MPH or equivalent degree, and a second year of "practicum" training in the practice of OEM. Our program addresses the "practicum "year. There is a number of Universities that allow an MPH degree through distance learning. In contrast to traditional residency practicum training which requires moving to an institution offering training, our program allows trainees to stay employed in their community, if suitable supervision, educational resources and experiences are available locally. Our training methods blend traditional medical residency, graduate school, and executive MBA education. Residents complete supervised clinical training at their community location. A variety of educational methods are used, resident's medical records are audited and they maintain a log of educational experiences. Core University of Pennsylvania faculty visit training locations four times a year to ensure the adequacy of training and supervision. Residents also spend 3 days a month in Philadelphia. Each resident undergo must complete a substantive project from their home base for each of: the workplace, hazard identification and control; environmental health, risk assessment and risk communication; organizational and health-care management; population occupational health and epidemiology; and the worker, fitness for work and disability. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Emmett, E A AU - Green-McKenzie, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Education KW - Communications KW - USA, Pennsylvania, Philadelphia KW - disabilities KW - schools KW - Health care KW - Training KW - USA, Pennsylvania KW - Medical personnel KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Emmett%2C+E+A%3BGreen-McKenzie%2C+J&rft.aulast=Emmett&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Community+and+Workplace-Based+Training+Program+for+Occupational+Medicine&rft.title=Community+and+Workplace-Based+Training+Program+for+Occupational+Medicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Occupational Injuries and Illnesses Among Latino Poultry Workers in Western North Carolina: Workplace Safety Climate AN - 19392255; 7157331 AB - Importance of Research Problem: Poultry is the largest and fastest growing segment of the U.S. meat products industry, which is vertically integrated and dominated by a few large corporations. 250,000 workers are employed in poultry processing; most are minority and immigrant (from Mexico, Guatemala, Southeast Asia, and the Pacific). Poultry processing is dangerous work, and immigrant workers have little control over their work environment. Bureau of Labor Statistics data are thought to underestimate occupational injury and illness among poultry workers. Community-based participatory research is an appropriate framework for occupational health research that cannot be conducted in the workplace and that seeks to study workers who are not enumerated. Objectives of this Study: This study (1) describes the most common types of occupational injuries and illnesses reported by poultry workers; (2) investigates the association of illness and injury rates and worker perceived safety climate across processing plants; and (3) recommends policy changes to reduce health disparities in occupational injuries in this vulnerable population. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Quandt, SA AU - Grzywacz, J G AU - Burke, B AU - Coates, M L AU - Marin, A AU - Carrillo, L AU - Arcury, T A Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - USA, North Carolina KW - poultry KW - Injuries KW - immigrants KW - Occupational safety KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Quandt%2C+SA%3BGrzywacz%2C+J+G%3BBurke%2C+B%3BCoates%2C+M+L%3BMarin%2C+A%3BCarrillo%2C+L%3BArcury%2C+T+A&rft.aulast=Quandt&rft.aufirst=SA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Injuries+and+Illnesses+Among+Latino+Poultry+Workers+in+Western+North+Carolina%3A+Workplace+Safety+Climate&rft.title=Occupational+Injuries+and+Illnesses+Among+Latino+Poultry+Workers+in+Western+North+Carolina%3A+Workplace+Safety+Climate&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Characteristics of Persons and Jobs with Needle-Stick Injuries in a National Data Set AN - 19392193; 7157290 AB - Importance and Objectives: Fear of needle-stick injuries is widespread among physicians, dentists, nurses and other health care workers. In recent years in the US, roughly 385,000 needle-stick injuries occurred annually among health care workers in hospitals alone. Roughly 400, 800, and 4 of these needle-stick injuries lead to hepatitis B, hepatitis C and HIV infections. We seek to describe the demographic and job characteristics of injured persons in a national data set never before analyzed for this purpose. Method: The U.S. Bureau of Labor Statistics (BLS) collects nationally representative data on occupational injuries. The BLS data largely reflect workers' compensation records. The BLS has two categories of interest: "needles and syringes" and "needle-sticks." We note advantages and disadvantages for both of these categories. We analyze data from 1992 through 2003. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Leigh, J P Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Statistics KW - Injuries KW - Fear KW - Occupational safety KW - needles KW - Infection KW - Medical personnel KW - Demography KW - infectious diseases KW - Workers KW - Hepatitis B KW - Syringes KW - Hepatitis C KW - workers' compensation KW - Data processing KW - Hepatitis KW - USA KW - Health care KW - Human immunodeficiency virus KW - nursing KW - Hospitals KW - V 22360:AIDS and HIV KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Leigh%2C+J+P&rft.aulast=Leigh&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Characteristics+of+Persons+and+Jobs+with+Needle-Stick+Injuries+in+a+National+Data+Set&rft.title=Characteristics+of+Persons+and+Jobs+with+Needle-Stick+Injuries+in+a+National+Data+Set&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Electrical Arc Injury Parameters and Prevention AN - 19392145; 7157279 AB - Research progress in the Electrical Arc Injury Parameters and Prevention study is influencing U.S. medical, electrical engineering, and electrical safety management. By encouraging multi-disciplinary, cross-functional, and inter organizational acknowledgment of the "multi-hazard nature" of an electrical arc incident, the basic science appreciation of injury as a resultant of energy transfer to the body is linked to electrical inputs and outputs in an electrical event. The findings relate to construction injury and fatality experience: While comprising about 7% of the U.S. workforce, construction workers sustained 44% of electrical fatalities. Our study has developed conceptual and three-dimensional computational models for electrical arc events and their use in severity rating blast conditions. In the study, we 1) Conceptually and mathematically modelled exposure to multiple hazards at the time of an electrical arc event including the acoustic forces which may result in barotraumas; 2) Simulated in 3D the potential blast explosion heat and acoustical force exposure at the time of an electrical arc event in different geographic / geometric settings; and 3) Compared the results with a. known thresholdsfor injury from acoustic forces, vibration, and acceleration-deceleration events; and b. recent experimentally acquired acoustic force measurements. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Capelli-Schellpfeffer, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - safety engineering KW - Injuries KW - Vibration KW - Occupational safety KW - prevention KW - Electricity KW - Construction industry KW - Explosions KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Capelli-Schellpfeffer%2C+M&rft.aulast=Capelli-Schellpfeffer&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Electrical+Arc+Injury+Parameters+and+Prevention&rft.title=Electrical+Arc+Injury+Parameters+and+Prevention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Construction Safety and Work-Family Balance: A Challenge and Unexplored Frontier AN - 19392116; 7157273 AB - Significance and Background: Few industries are plagued by more workplace injuries than the construction industry, which had the highest death rate in 2004 when compared to other occupations (BLS, 2004). Compared to other occupations, construction workers also have the highest rate of mental health problems that manifest themselves in either alcohol or substance abuse (Foster & Vaughn, 2005), which would inevitably affect workers' safety and health. Although the physical environments (e.g., hazardous work conditions) have been improved, the unique nature of construction work requires special attention to the human-related systems such as the interaction between work and family. We see work-family conflict as an important but neglected safety hazard. Specifically, we argue that when workers are preoccupied with concern and thoughts about their work and family, they are more likely to get injured due to distraction. An additional issue related to work-family conflict and safety in the construction industry, is that construction workers are rarely permanent employees because they work for different contractors for different jobs at different time. Thus, supportive organizational work-family policies are virtually non-existent due to the nature of the job. Workers often leave home very early, work longer hours, and travel away from home for weeks or months without any clear attachment to an employer. Foremost, this newly-recognized challenge is unlikely in practice addressed by safety and technical trainings, enforcement of safety policies, or provisions of personal protected equipment. Aims: To address the above challenge, we examined two essential questions as the first step to explore this new frontier. First, how would conflict between work and family (i.e., conflicting roles pressure from work and family) predict workers' mental and physical health, injuries and pain reports? Second, how would family support that workers received predict the above outcomes? Both questions would help us substantiate the roles of work and family interface in construction safety and health. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Chen, P Y AU - Rosecrance, J AU - Hammer, L B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Travel KW - substance abuse KW - Alcohol KW - Mortality KW - Injuries KW - Training KW - Residential areas KW - pain KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chen%2C+P+Y%3BRosecrance%2C+J%3BHammer%2C+L+B&rft.aulast=Chen&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Construction+Safety+and+Work-Family+Balance%3A+A+Challenge+and+Unexplored+Frontier&rft.title=Construction+Safety+and+Work-Family+Balance%3A+A+Challenge+and+Unexplored+Frontier&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Community Partners for Healthy Farming Intervention Research AN - 19392078; 7157247 AB - Agriculture is among the most hazardous industries with an unintentional death rate in 2001 of 21.0 per 100,000 workers for agriculture vs. 3,6 for workers in all industries (National Safety Council, 2002). Agriculture varies in terms of farm size, hazards, labor regulations, and owner autonomy. Although many intervention strategies have been tried, knowledge about what works best is limited. The purpose of the Community Partners for Healthy Farming Intervention Research (CPHF-IR) program is to implement and evaluate existing or new interventions for reduction of agriculturally-related injuries, hazards, and illnesses. Consistent with the objectives, synergistic partnerships between experienced researchers and stakeholders, e.g. communities, workers, managers, agricultural organizations, agribusinesses and media, provided their unique resources for accessing the target populations, guidance throughout the research process, dissemination, and building infrastructure for further promotions of agricultural safety and health. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Ehlers, J K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - Mortality KW - Farms KW - Injuries KW - Occupational safety KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19392078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ehlers%2C+J+K&rft.aulast=Ehlers&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Community+Partners+for+Healthy+Farming+Intervention+Research&rft.title=Community+Partners+for+Healthy+Farming+Intervention+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - An Action Agenda for Commercial Motor Vehicle Driver Safety AN - 19391121; 7157379 AB - The Federal Motor Carrier Safety Administration (FMCSA), an agency of the U.S. Department of Transportation, is embarking on a major set of initiatives to improve highway safety by focusing on the world and work of the truck and bus driver. In 2005, the agency began a program to review and revise the driver medical qualifications, including establishment of a Medical Review Board and merging the physical qualifications and Commercial Drivers License (CDL) standards. In 2006, the agency will expand the initiative to explore driver skills acquisition and enhancement, particularly for the entry-level driver. It will also continue its review of State licensing oversight and implementation of CDL sanctions. The agency will also expand a 2004 pilot Driver Violation Notification Service Feasibility Study program where State licensing agencies automatically notify employers when their CDL drivers are convicted of driving violations or experience CDL status changes. Finally, changes in demographics, attractiveness of other occupations, and many other factors are contributing to a current and projected shortage of truck and drivers. Given that the U.S. economy depends on trucking - in 2002, trucks hauled about 64 percent of the value, 58 percent of the tonnage, and 32 percent of the ton-miles of total shipments - and that highway passenger transportation serves many communities and users with limited access to other transportation - it is in the Nation's interest to continue to develop and nurture the drivers of the future. FMCSA will explore this important concern in concert with its industry and safety partners and stakeholders. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Freund, D M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - Accidents KW - Transportation KW - Reviews KW - Motor vehicles KW - Licensing KW - Economics KW - Occupational safety KW - Trucks KW - Highways KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Freund%2C+D+M&rft.aulast=Freund&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=An+Action+Agenda+for+Commercial+Motor+Vehicle+Driver+Safety&rft.title=An+Action+Agenda+for+Commercial+Motor+Vehicle+Driver+Safety&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Reducing Injuries in Underground Mining Through the Application of Waterjet Scaling AN - 19391070; 7157370 AB - A review of accident and fatality statistics for underground metal/nonmetal mines show that nearly one-quarter of all fatalities at these operations were related to rock falls, where nearly one-third of these fatalities involved scaling activities. In response to this detrimental trend, research is being conducted to evaluate the effectiveness of using high-pressure waterjet technology as part of a mechanized scaling system to safely remove loose and unstable rock from underground mine openings. Sponsored by CDC NIOSH, this project builds upon previous research in waterjet scaling performed by the authors, where waterjet scaling has been shown to be a viable alternative to conventional scaling methods. With the current research program, the relative effectiveness of various nozzles designs, including continuous, oscillating, and two types of pulsed jets, are being examined. It is believed hat the utilization of a properly designed waterjet system will provide significant improvements in employee safety over that of conventional manual or mechanized scaling methods by removing miners from high-risk areas and reducing their potential exposure to rock falls. Additional benefits stem from the ability to utilize high velocity fluid to scarify and clean rock surfaces, thereby substantially improving the performance and adhesion characteristics of shotcrete as a ground support membrane. Focal to this proposed research are efforts to empirically quantify the critical operating variables associated with hydraulic scaling and to assess the performance and efficiency of these systems relative to conventional scaling methods in terms of employee health and safety. The project will conclude by performing an extensive field trial at an operating underground mine, where exposure assessments and risk analysis will be conducted. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kuchta, ME AU - Miller, H B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Metals KW - Hydraulics KW - Accidents KW - Reviews KW - Occupational safety KW - Velocity KW - Mines KW - Research programs KW - scaling KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kuchta%2C+ME%3BMiller%2C+H+B&rft.aulast=Kuchta&rft.aufirst=ME&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Reducing+Injuries+in+Underground+Mining+Through+the+Application+of+Waterjet+Scaling&rft.title=Reducing+Injuries+in+Underground+Mining+Through+the+Application+of+Waterjet+Scaling&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Dynamic Strength and Knowledge of Strength Affect Manual Materials Handling Strategy AN - 19391021; 7157347 AB - This study investigated (1) whether there is a relation between dynamic (isokinetic) strength and the batch-assorting strategy to initiate a manual materials handling task, and (2) how knowledge of strength influences the relation. Thirty-two participants (16 men and 16 women) were first tested for their isokinetic strengths of trunk extension, knee extension, shoulder extension, and shoulder abduction. The participants were then divided into two groups, each with 8 men and 8 women, such that the between-group strength difference was minimized. One group received knowledge feedback of their strength testing results and the other did not. All participants subsequently performed the same load handling task in which they were asked to carry batches of various weight plates while allowed to assort batches of more than one plate into any combination. Results suggested that people with greater strength tended to adopt a more aggressive handling strategy--heavier load per carry and fewer carries per batch. Receiving knowledge feedback also evoked a tendency of more aggressiveness, which was more salient in the weaker individuals. The research findings lend support to the use of strength testing in identifying higher risk handlers, and have implications for designing repetitive materials handling jobs and proper instructions to promote better strategies of balancing productivity and injury prevention. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Zhang, X AU - Bartlett, D B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Materials handling KW - prevention KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Zhang%2C+X%3BBartlett%2C+D+B&rft.aulast=Zhang&rft.aufirst=X&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Dynamic+Strength+and+Knowledge+of+Strength+Affect+Manual+Materials+Handling+Strategy&rft.title=Dynamic+Strength+and+Knowledge+of+Strength+Affect+Manual+Materials+Handling+Strategy&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Recovery Pattern of Neck and Shoulder Pain among Sewing Machine Operators AN - 19391006; 7157355 AB - Introduction: Few studies to date have addressed recovery from work-related musculoskeletal pain. The aim of this study was to explore factors that may affect or modify recovery from a neck/shoulder disorder among garment workers. Garment workers have elevated rates of neck/shoulder pain and disorders due to sustained shoulder abduction and neck flexion. Methods: This 4-month prospective cohort study followed 129 sewing machine operators who reported neck/shoulder pain at baseline before adopting ergonomic interventions.Musculoskeletal pain data was gathered in a standardized interview at baseline and during the follow-up period. Recovery pattern was evaluated using a proportional pain score of baseline pain in percentile as a continuous measurement of severity by multiplying pain frequency and pain intensity to generate a pain score, and dividing the score at each survey by the baseline score for each individual. Linear mixed models were used to examine the association between individual characteristics and work-related ergonomic and psychosocial factors on overall reduction of pain from baseline to four months and average reduction rate of pain per month while controlling for the intervention. Conclusion: These results suggest that baseline musculoskeletal pain is positively associated with pain recovery rate. Individual and ergonomic factors, but not psychosocial factors, were associated with pain recovery. The total rest period duration in a day should be considered when managing neck/shoulder pain among garment workers. These findings suggest that the medical management of neck/shoulder pain among workers performing work involving static neck and shoulder loads should consider both individual (age) and work-related factors (work-rest pattern). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Rempel, D AU - Wang, J AU - Ritz, B AU - Harrison, R AU - Janowitz, I Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - sewing machine operators KW - Health & Safety Science Abstracts KW - pain KW - Ergonomics KW - working conditions KW - musculoskeletal system KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rempel%2C+D%3BWang%2C+J%3BRitz%2C+B%3BHarrison%2C+R%3BJanowitz%2C+I&rft.aulast=Rempel&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Recovery+Pattern+of+Neck+and+Shoulder+Pain+among+Sewing+Machine+Operators&rft.title=Recovery+Pattern+of+Neck+and+Shoulder+Pain+among+Sewing+Machine+Operators&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - How Well Does the Strain Index Predict Carpal Tunnel Syndrome? AN - 19390968; 7157336 AB - Introduction: Work-related carpal tunnel syndrome (CTS) involves compression of the median nerve at the wrist. It can result in decreased hand function, long disability and high medical costs. We conducted a three-year prospective study of carpal tunnel syndrome incidence in the manufacturing and health care sectors in Washington State using individual exposure assessment and health assessment methods. Methods: This prospective study in 12 workplaces consisted of baseline and follow-up data collection every four months over three years. Health assessment included health and job history, physical examination, psychosocial questionnaires and electrodiagnostic testing. Carpal tunnel syndrome was defined as: 1) recurring symptoms of numbness/tingling/pain in median nerve distribution of the hand present during the interview week and not due to acute trauma and 2) positive electrodiagnostic tests for the median motor/sensory nerve at the wrist. Individual job exposure data was collected at baseline and after job change. We collected data to calculate a strain index (Moore and Garg 1995) (SI) for each hand and a cumulative SI (CSI) similar to the NIOSH lifting equation method for multiple lifts. We then multiplied the CSI by the number of years the worker was on that job, and added additional CSI*years for job changes over time (CSIYRS). We also collected Hand Activity Level (HAL) and peak hand force data according to the ACGIH (ACGIH 2003). We used Cox proportional hazard model to assess the relationship between incidence of CTS and individual, psychosocial and physical exposure measures (proc phreg, SAS 9.1). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Silverstein, BA AU - Fan, Z J AU - Bao, S AU - Spielholz, P AU - Howard, N AU - Smith, C AU - Bonauto, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Washington KW - Historical account KW - Data collection KW - disabilities KW - Health care KW - carpal tunnel syndrome KW - overuse injuries KW - pain KW - lifting KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Silverstein%2C+BA%3BFan%2C+Z+J%3BBao%2C+S%3BSpielholz%2C+P%3BHoward%2C+N%3BSmith%2C+C%3BBonauto%2C+D&rft.aulast=Silverstein&rft.aufirst=BA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=How+Well+Does+the+Strain+Index+Predict+Carpal+Tunnel+Syndrome%3F&rft.title=How+Well+Does+the+Strain+Index+Predict+Carpal+Tunnel+Syndrome%3F&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Longitudinal Evaluation of the Effectiveness of Minority Worker Health and Safety Training Programs in Eight Communities AN - 19390945; 7157333 AB - Although recognized as a priority area under the National Occupational Research Agenda, there continues to be a need for comprehensive systematic evaluation research on the effectiveness of minority health and safety training programs. More specifically, few long-term studies exist with respect to evaluating training and communication approaches and other prevention strategies to identify those that are most effective for disadvantaged minority youth. In response, a comprehensive evaluation process was developed to address this important area of research. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Sarpy, SAC AU - Kaufman, J D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Education KW - Communications KW - Training KW - Occupational safety KW - prevention KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sarpy%2C+SAC%3BKaufman%2C+J+D&rft.aulast=Sarpy&rft.aufirst=SAC&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Longitudinal+Evaluation+of+the+Effectiveness+of+Minority+Worker+Health+and+Safety+Training+Programs+in+Eight+Communities&rft.title=A+Longitudinal+Evaluation+of+the+Effectiveness+of+Minority+Worker+Health+and+Safety+Training+Programs+in+Eight+Communities&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Workload-Related Musculoskeletal Disorders Among Hotel Housekeepers: Worksite Surveillance Reveals a Growing National Problem AN - 19390914; 7157321 AB - The hotel industry employs over 1.4 million people. Hotel workers, in general, are 40% more likely to be injured on the job than the typical worker in the service sector. Over 400,000 of these are maids and housekeepers -- the largest job classification within hotels -- who are particularly at risk. Of all U.Ss private sector job categories, they rank near the top (20th) annually in the number of disabling injuries reported by the Bureau of Labor Statistics. Most of these workers are women, many are immigrants, and typically are paid $8.00/hour. Work-related pain and injury among housekeepers have been shown to be under-reported, making early detection, adequate treatment, and prevention of injuries and associated disability difficult. New analyses of workplace surveillance data include 1) formally-reported injuries/illnesses, 2) informally-reported prevalence of pain and 3) trends in working conditions (i.e. new equipment, limitations in available break time, inadequate supervision and training). The most frequent workplace stressors associated with disabling conditions involve bodily exertion, awkward position, repetitive work and musculoskeletal and psychological strain. These studies have identified a variety of health and safety risk factors, and offer compelling reasons for employers, labor unions, workers and insurance carriers to direct their attention to prevention efforts. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Frumin, E AU - Vossenas, P AU - Moriarty, J Y AU - Orris, P AU - Halpin, J AU - Krause, N AU - Punnett, L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - hotel industry KW - Health & Safety Science Abstracts KW - Injuries KW - disabilities KW - immigrants KW - Psychology KW - Training KW - prevention KW - pain KW - Insurance KW - musculoskeletal system KW - working conditions KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Frumin%2C+E%3BVossenas%2C+P%3BMoriarty%2C+J+Y%3BOrris%2C+P%3BHalpin%2C+J%3BKrause%2C+N%3BPunnett%2C+L&rft.aulast=Frumin&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Workload-Related+Musculoskeletal+Disorders+Among+Hotel+Housekeepers%3A+Worksite+Surveillance+Reveals+a+Growing+National+Problem&rft.title=Workload-Related+Musculoskeletal+Disorders+Among+Hotel+Housekeepers%3A+Worksite+Surveillance+Reveals+a+Growing+National+Problem&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Assessing Fall Risks in Residential Construction AN - 19390906; 7157274 AB - Falls are a leading cause of mortality and morbidity in construction. Residential carpenters work on small, often-dispersed worksites making it particularly challenging to understand their work exposures and subsequent risk. Surveillance data lack enough detail to allow clear delineation of these workers. As part of a comprehensive needs assessment designed to improve training of residential carpenter apprentices we conducted a series of activities to identify essential training elements for the prevention of falls among apprentices, their attitudes towards fall risk and safety measures, training they receive, and fall hazards to which they are exposed. Initially, we reviewed published literature on falls in residential carpentry, NIOSH FACE investigations, and reports of 850 falls from height among residential carpenters in North Carolina, Missouri, and California captured through workers' compensation reports and active surveillance. We conducted a series of focus groups with carpenter apprentices (n=36) at various stages of their training and held discussion groups with apprenticeship trainers. Audits were conducted on 70 residential sites designed to identify fall hazards and how hazards were abated. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dale, A M AU - Kaskutas, V AU - Lipscomb, H AU - Gaal, J AU - Fuchs, M AU - Nolan, J AU - Patterson, D AU - Evanoff, B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - workers' compensation KW - USA, North Carolina KW - Mortality KW - Falls KW - Training KW - Occupational safety KW - Working conditions KW - Morbidity KW - Reviews KW - prevention KW - USA, Missouri KW - USA, California KW - Construction industry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dale%2C+A+M%3BKaskutas%2C+V%3BLipscomb%2C+H%3BGaal%2C+J%3BFuchs%2C+M%3BNolan%2C+J%3BPatterson%2C+D%3BEvanoff%2C+B&rft.aulast=Dale&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Assessing+Fall+Risks+in+Residential+Construction&rft.title=Assessing+Fall+Risks+in+Residential+Construction&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Fiber Deposition in the Human Respiratory Tract AN - 19390875; 7157309 AB - Asbestos is a notorious occupational hazard. Exposure to airborne asbestos fibers in the workplace increases the incidence of lung cancer, fibrosis, and mesothelioma for asbestos miners and workers. Although the use of asbestos fibers was banned by the U.S. Environmental Protection Agency in 1989, new fiber materials such as man-made vitreous fibers (MMVFs) are being manufactured to replace asbestos for new applications. However, some research studies conducted in laboratory animals have shown that certain MMVFs may have a biological effect similar to that of asbestos. Therefore, it is believed that a potential risk of fiber-related diseases for workers in the MMVF textile industry still exists. The health effects of exposure to fiber strongly depend upon the regional and local sites in the human respiratory tract where the fiber deposits. By knowing these sites of preferred deposition and the corresponding fiber dimension distribution at these sites, the understanding of the etiological process and the determination of hazard for fiber-related lung diseases would improve significantly. However, ethicalconstraints severely limit the use of fibers in human volunteer studies. Hence, the experimental data are extremely limited on this topic. This lack of data makes the nature of fiber deposition in the human respiratory tract to remain unknown and also hampers the verification of available lung deposition models. The goal of this research is to obtain sufficient experimental data for fiber deposition in the human respiratory tract for investigating the deposition patterns and mechanisms. In this study, realistic human respiratory tract replicas with well-defined airway geometry were made that included the nasal airway, oral airway, and tracheobronchial airways. MMVFs were used as the test fiber material including glass fibers and carbon fibers. The fiber deposition experiments were conducted by delivering fiber aerosol into the replicas with three inspiratory flow rates (15,43.5, and 60 1/min), which cover an adult breathing rate from rest to performing moderate exercise. The post-experimental procedure was then carried out to obtain the fiber deposition information from each region of the replica. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Su, W C AU - Cheng, Y S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Asbestos KW - Aerosols KW - Glass KW - Textile industry KW - Flow rates KW - Fibers KW - EPA KW - USA KW - mesothelioma KW - Occupational exposure KW - Respiratory tract KW - Lung cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Su%2C+W+C%3BCheng%2C+Y+S&rft.aulast=Su&rft.aufirst=W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Fiber+Deposition+in+the+Human+Respiratory+Tract&rft.title=Fiber+Deposition+in+the+Human+Respiratory+Tract&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Risk Factors for Nail Gun Injuries in Apprentice Carpenters AN - 19390871; 7157271 AB - Pneumatic nail guns have increased productivity in wood frame construction but not without cost. Injuries from these tools are among the most common in residential construction and apprentice carpenters are at particularly high risk. These injuries have been portrayed as freak "accidents" in the press in recent years. This project was designed to more clearly document the magnitude of this injury problem among apprentice carpenters and to evaluate the effect of training in tool use and tool design on injury risk. Questionnaire data were collected from 732 apprentice carpenters enrolled in two training schools in the Midwest between January and July 2005. The carpenters were asked about heir injury experience, training, work hours, and tool use. Each carpenter was asked specifically to estimate hours of nail gun use in a typical week. Injured carpenters (n=216; 63% of injured) participated in a detailed surveillance interview conducted by experienced journeymen carpenters to capture information on the circumstances surrounding their injuries. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Lipscomb, HJ AU - Dement, J M AU - Nolan, J AU - Patterson, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - nail guns KW - Health & Safety Science Abstracts; Risk Abstracts KW - Accidents KW - Injuries KW - Training KW - Man-machine interactions KW - Occupational safety KW - Hand tools KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lipscomb%2C+HJ%3BDement%2C+J+M%3BNolan%2C+J%3BPatterson%2C+D&rft.aulast=Lipscomb&rft.aufirst=HJ&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Risk+Factors+for+Nail+Gun+Injuries+in+Apprentice+Carpenters&rft.title=Risk+Factors+for+Nail+Gun+Injuries+in+Apprentice+Carpenters&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Fall Safe Project AN - 19390837; 7157280 AB - Broad Importance of the Research Problem: Falls are the leading cause of fatalities and major cause of injury in construction work. While the construction workforce represents 5% of the nation's workforce, it accounts for 49.6% of fall fatalities. The construction safety profession recognizes available engineering controls, work practices, and personal protection, which are effective in preventing construction falls. However the equipment and practices are not consistently used in the industry. Fall Safe developed and tested a fall prevention system for control of construction fall hazards. This system establishes a partnership between the university and construction contractors. The partnership is established by a contractual relationship through which contractors obtain "Fall-Safe" status by implementing a fall hazard management system. Purpose or Objectives of the Study: By implementing a fall hazard management system, contractors should improve fall hazard performance. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Takacs, B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - safety engineering KW - Contracts KW - Falls KW - Injuries KW - Occupational safety KW - prevention KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Takacs%2C+B&rft.aulast=Takacs&rft.aufirst=B&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Fall+Safe+Project&rft.title=The+Fall+Safe+Project&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Deck Safety in the Commercial Fishing Industry: Development of an Emergency-Stop System for a Hydraulic Deck Winch AN - 19390836; 7157251 AB - Research Problem: The deck of a commercial fishing vessel is an unstable work platform that is constantly moving and often congested with machinery and equipment. Much of the machinery on commercial fishing vessels is rudimentary and has inadequate safety controls. The NIOSH Alaska Field Station (NIOSH AFS) has found that unlike fatalities in the fishing industry which are usually due to the loss of a vessel (87% nationally, 86% Alaska) (Lincoln and Conway 1999; Dickey 2003), most (67%) severe non-fatal injuries occur on deck during the deployment and retrieval of fishing gear (Lincoln and Conway 1999; Thomas, Lincoln et al. 2001). There were 574 severe non-fatal injuries that occurred in the commercial fishing industry during 1991-1998. This is equivalent to an annual rate for serious hospitalized injuries of 410/100,000 full-time fishermen. Machinery and fishing equipment accounted for 40% of non-fatal injuries, while another 27% were due to falls. These machinery-related injuries resulted from cables, chains, lines, winches, pot launchers and other deck equipment. Being trapped in a winch caused 35% of these machinery injuries (Thomas, Lincoln et al. 2001). Deck machinery and gear is also a factor in many fatal injuries aboard fishing vessels. The USCG has documented that from 1994-2000, 37 (8%) of all fishing related fatalities nationally were a result of either getting caught in gear, or getting struck by gear while operating machinery. (Dickey 2003). At least eight of these fatalities were due to winch entanglements. These fatalities can be prevented when practical engineering solutions can be developed. Purpose: The purpose of this study was to take epidemiological data to industry to learn about hazards on deck and then to work with engineers to design out the identified hazards. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Lincoln, J M AU - McKibbin, R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Alaska KW - Mortality KW - Commercial fishing KW - Hydraulics KW - safety engineering KW - Injuries KW - Machinery KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lincoln%2C+J+M%3BMcKibbin%2C+R&rft.aulast=Lincoln&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Deck+Safety+in+the+Commercial+Fishing+Industry%3A+Development+of+an+Emergency-Stop+System+for+a+Hydraulic+Deck+Winch&rft.title=Deck+Safety+in+the+Commercial+Fishing+Industry%3A+Development+of+an+Emergency-Stop+System+for+a+Hydraulic+Deck+Winch&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Designing for Safety in the Construction of Single-Family Homes AN - 19390799; 7157268 AB - Among the nine major industrial groups in the United States the construction industry typically ranks among the top three for having the highest annual fatality rate. Falls from or through roofs have been the leading causes of these fatalities for the past two decades. The research I am currently involved in consists of analyzing narrative descriptions of fatality investigations of all fatal events associated with the construction industry. The primary purpose of the analysis is to provide the agency sponsoring the research with information associated with the proximal cause of the incident as well as offer suggestions as to how these situations may be avoided in the future. In addition the knowledge gained as a result of this research provides information which leads to customized training programs for the industries workers as well as the responsible writing of new safety standards and codes that are to be enforced and adhered to on construction sites. Currently I am involved in a study assessing the proximal cause of fatalities occurring during the construction of single-family homes. The study encompasses not only new construction but also fatalities which may occur in association with re-modelling or additions to existing single-family homes. An examination of more than seventy case files selected from a three year time period indicated that the leading causes of fatal events for this type of construction are various types of falls, electrocutions, and crushing incidents. In addition we determined that nearly every incident reviewed could have been avoided provided the proper preventative measures were taken. Potential preventative measures may be but are not limited to the provision of adequate safety and training courses, the existence of a competent person on site, or the proper use of safety equipment. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Fry, BA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Training KW - Reviews KW - Occupational safety KW - Residential areas KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fry%2C+BA&rft.aulast=Fry&rft.aufirst=BA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Designing+for+Safety+in+the+Construction+of+Single-Family+Homes&rft.title=Designing+for+Safety+in+the+Construction+of+Single-Family+Homes&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Pesticide Exposure among Children in Farmworker Households in Eastern North Carolina AN - 19390798; 7157241 AB - Importance of Research Problem: Organophosphorus (OP) pesticide exposure among migrant and seasonal farmworker families, particularly among children, is a growing concern. OP pesticide exposure can cause immediate health problems, ranging from nausea and dermatitis to coma and death. Additionally, the delayed effects of OP pesticide exposure, particularly among children, can also have great impacts, including increased risk for retarded neurobehavioral development and for cancer. The levels and predictors of OP pesticide exposure among farmworker children must be delineated to inform procedures for minimizing children's OP pesticide exposure. Objectives of this Study: This study (1) describes the urinary OP pesticide metabolite levels among children living in Latino farmworker households located in eastern North Carolina, (2) compares the OP metabolite levels of these children with national reference data, and (3) delineates the relative importance of risk factors for urinary OP pesticide metabolite levels among these children based on a systematic model of pesticide exposure. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Arcury, T A AU - Barr, D B AU - Davis, S W AU - Grzywacz, J G AU - Quandt, SA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, North Carolina KW - Mortality KW - Sulfur dioxide KW - Urine KW - Pesticides KW - dermatitis KW - Metabolites KW - Children KW - Seasonal variations KW - Ethnic groups KW - Cancer KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Arcury%2C+T+A%3BBarr%2C+D+B%3BDavis%2C+S+W%3BGrzywacz%2C+J+G%3BQuandt%2C+SA&rft.aulast=Arcury&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Pesticide+Exposure+among+Children+in+Farmworker+Households+in+Eastern+North+Carolina&rft.title=Pesticide+Exposure+among+Children+in+Farmworker+Households+in+Eastern+North+Carolina&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Development and Pilot Testing of "First Aid Farm Quest," an Interactive CD Focusing on First Aid and Injury Risk Reduction for Farm Youth AN - 19390764; 7157262 AB - Farmers are among the highest risk groups for occupational injury and illness. Because youth work side-by-side with adults, they may be called upon to activate EMS and provide lifesaving skills till help arrives. Needs survey of 657 farm women in southeast Louisiana revealed that only 21% attended first aid classes in the previous year. Focus group interviews confirmed that women believe there is a need for first aid training of all family members but few opportunities to attend training sessions. To address the expressed need for training and the concern for unintentional injuries among farm youth and friends, an interactive CD titled "First Aid Farm Quest" was developed targeting, 5th and 6th graders, by a partnership of rural university health professionals, communication/graphic artists, agricultural extension professionals, and farm women and children. Development of the CD not only sought to demonstrate first aid skills but also to introduce hazards that potentially lead to injury or harm. First aid skills are reinforced with multimedia computer-based games. Injury prevention messages are integrated throughout the program. Raising awareness and reinforcing safebehaviors and situations is the focus of the last module titled "Safety Countdown.". JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Carruth, A K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - risk reduction KW - Communications KW - Injuries KW - Training KW - Occupational safety KW - USA, Louisiana KW - prevention KW - Children KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Carruth%2C+A+K&rft.aulast=Carruth&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Development+and+Pilot+Testing+of+%22First+Aid+Farm+Quest%2C%22+an+Interactive+CD+Focusing+on+First+Aid+and+Injury+Risk+Reduction+for+Farm+Youth&rft.title=The+Development+and+Pilot+Testing+of+%22First+Aid+Farm+Quest%2C%22+an+Interactive+CD+Focusing+on+First+Aid+and+Injury+Risk+Reduction+for+Farm+Youth&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - MRI-induced heating of selected thin wire metallic implants -laboratory and computational studies - findings and new questions raised AN - 19390667; 7152235 AB - We performed experiments and computer modeling of heating of a cardiovascular stent and a straight, thin wire by RF fields in a 1.5 T MRI birdcage coil at 64 square MHz. We used ASTM F2182-02a standard and normalized results to 4 square W/kg whole body average. We used a rectangular saline-gel filled phantom and a coiled, double stent (Intracoil by ev3 Inc) 11 square cm long. The stent had thin electrical insulation except for bare ends (simulating drug eluting coating). The stent and phantom were placed close to the wall of the RF Coil and had approximately 0.5 degree C initial temperature rise at the ends (local SAR = 320 square W/kg). We exposed a wire (24.1 square cm, 0.5 square mm diameter) with 0.5 square mm insulation and saw an 8.6 degree C temperature rise (local SAR = 5680 square W/kg) at the bare ends. All heating was within 1 square mm super(3) of the ends, so the position of our fiber optic temperature probe was critical for repeatability. Our computational study used finite difference time domain software with a thermodynamics solver. We modeled a coiled bare-wire stent as a spiral with a rectangular cross section and found a maximum increase of 0.05 degree C induced at the tips for plane wave exposures. A maximum local SAR of up to 200DW/kg occurred in a volume of only 8x10 super(-3) square mm. We developed improved computational exposure sources - optimized birdcage coils and quasi-MRI fields that may eliminate the need to model an RF coil. We learned that local (point) SAR (initial linear temperature rise) is the most reliable indicator of the maximum heating of an implant. Local SAR depends greatly on implant length, insulation and shape, and position in the MRI coil. Accurate heating must be measured with sensors or software having millimeter resolution. Many commercially available fiber optic temperature probes do meet this requirement. JF - Minimally Invasive Therapy & Allied Technologies AU - Bassen, H AU - Kainz, W AU - Mendoza, G AU - Kellom, T AD - US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 76 EP - 84 VL - 15 IS - 2 SN - 1364-5706, 1364-5706 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Thermodynamics KW - Computers KW - Magnetic resonance imaging KW - Temperature requirements KW - Computer applications KW - Models KW - Fibers KW - Computer programs KW - software KW - Drugs KW - Coatings KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Minimally+Invasive+Therapy+%26+Allied+Technologies&rft.atitle=MRI-induced+heating+of+selected+thin+wire+metallic+implants+-laboratory+and+computational+studies+-+findings+and+new+questions+raised&rft.au=Bassen%2C+H%3BKainz%2C+W%3BMendoza%2C+G%3BKellom%2C+T&rft.aulast=Bassen&rft.aufirst=H&rft.date=2006-04-01&rft.volume=15&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Minimally+Invasive+Therapy+%26+Allied+Technologies&rft.issn=13645706&rft_id=info:doi/10.1080%2F13645700600640931 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Computer applications; Computer programs; Temperature effects; software; Fibers; Magnetic resonance imaging; Models; Computers; Coatings; Thermodynamics; Temperature requirements; Drugs DO - http://dx.doi.org/10.1080/13645700600640931 ER - TY - BOOK T1 - Safe Approaches to Nanotechnology: An Information Exchange with NIOSH AN - 19390666; 7157397 AB - Nanotechnology has been described as one of the fastest growing technological areas in history and has the potential to revolutionize global industry by changing and improving products in many sectors. As with any new technology, there are a number of unknowns which generate awareness and concern in the occupational safety and health community. The National Institute for Safety and Health (NIOSH) has played a leading role in conducting research on the potential implications and applications of nanotechnology on workplace safety and health, and is committed to ensuring worker protection as this technology evolves. NIOSH has developed and posted on its web site the document Approaches to Safe Nanotechnology: An Information Exchange with NIOSH to raise awareness of potential safety and health concerns from exposure to nanomaterials. A key feature of this document is the ability for readers to provide feedback to NIOSH in the form of comments, recommendations, and case studies in response to the initial guidance being offered. The broad scope, diversity, and rapid developments in nanotechnology make it impossible to offer definitive guidelines or practices that will apply to all situations. However, the NIOSH document will provide a vehicle for more rapid sharing of results from NIOSH studies; a means to share lessons from the OS&H community; and a more effective process for translating findings from field and research studies into practices that can be applied. The document presents information that is the Institutes current knowledge and opinion. As the knowledge base on nanotechnology grows, NIOSH intends to provide updates on the guidance for the safe handling of nanoparticles and other safe approaches to nanotechnology. Safe Approaches to Nanotechnology: An Information Exchange with NIOSH can be found at http://www.cdc.gov/niosh/topics/nanotech/nano_exchange.html. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Geraci, CL AU - Zumwalde, R D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Historical account KW - Occupational safety KW - Occupational exposure KW - nanotechnology KW - Information exchange KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Geraci%2C+CL%3BZumwalde%2C+R+D&rft.aulast=Geraci&rft.aufirst=CL&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Safe+Approaches+to+Nanotechnology%3A+An+Information+Exchange+with+NIOSH&rft.title=Safe+Approaches+to+Nanotechnology%3A+An+Information+Exchange+with+NIOSH&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Theory-Driven, Evidence-Based Intervention: Seven Years, Four Thousand Businesses, Three Safer Ways To Work AN - 19390647; 7157237 AB - Broad Importance of the Research Problem: In most industries, many managers continue to rely on "older" production practices despite the ready availability of practices that can be more effective, less costly, and less hazardous to the health of the workforce but that, for various reasons, are not yet widely used. Often, what appears to stand in the way is a lack of awareness on the part of firm managers about the existence, value, and ease of use of the improved practices, at least in part attributable to the absence of convincing, comprehensive, and well-targeted interventions to optimize information flow. Our research results provide evidence that better information flow can be associated with increased adoption of safer production practices. Purpose: Dairy work is especially hazardous compared to agricultural work overall. Previous research shows that agricultural managers resist adopting safer practices because they face few penalties for unsafe work and because many safer practices reduce profits compared to traditional practices. Consistent with production theory in economics, agricultural managers are known to adopt more profitable practices quickly. Methods: Our intervention promoted three practices that were more profitable than traditional practices and reduced safety hazards: Barn lights improve both milk production and workplace visibility and reduce risks of falls and animal contact injuries versus poorly lighted barns. Bag silos require less work to store and access feed and reduce fall, asphyxiation, and machinery injury hazards versus traditional tower silos. Calf feeding systems reduce feeding time and musculoskeletal injury hazards versus traditional feed carrying and lifting to calf hutches. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Chapman, L J AU - Pereira, K M AU - Newenhouse, A C Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - Dairies KW - Milk KW - Injuries KW - Machinery KW - Economics KW - Occupational safety KW - feeding KW - lifting KW - musculoskeletal system KW - Feeds KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chapman%2C+L+J%3BPereira%2C+K+M%3BNewenhouse%2C+A+C&rft.aulast=Chapman&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Theory-Driven%2C+Evidence-Based+Intervention%3A+Seven+Years%2C+Four+Thousand+Businesses%2C+Three+Safer+Ways+To+Work&rft.title=A+Theory-Driven%2C+Evidence-Based+Intervention%3A+Seven+Years%2C+Four+Thousand+Businesses%2C+Three+Safer+Ways+To+Work&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Abuse and Violence During Home Care Work as Predictor of Worker Depression AN - 19390640; 7157385 AB - Importance: Abuse and violence towards workers are present in many healthcare work environments. When the workplace is a private home, the normal protections that workers have in hospital settings (e.g. co-workers, security guards, alarm systems) are not present. Because home care workers perform their duties in isolation, they must rely on their own resources to deal with abuse and violence. Once abusive or violent events occur in the home, the home care worker must return to deliver care, and fears reoccurrences of these events. This fear can be debilitating, and is linked to negative mental health outcomes. Purpose: Therefore, the purpose of this longitudinal study is to describe the prevalence of abuse and violence experienced by home care workers as well as to examine its relation to the incidence of depression. Methods: A two-wave computer assisted telephone survey (N=1643) (English/Spanish) was conducted to assess the prevalence of abuse situations and incidence of worker depression. Findings: Significantly elevated odds for depression were associated with each abuse variable, and there was a dose effect seen when comparing low and high levels of abuse with no abuse. Violence during home care was uncommon (< 4% of sample) but highly associated with depression. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Brown, J G AU - Muntaner, C AU - Lipscomb, J AU - Trinkoff, A Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Health care KW - Occupational safety KW - Residential areas KW - security KW - Violence KW - depression KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brown%2C+J+G%3BMuntaner%2C+C%3BLipscomb%2C+J%3BTrinkoff%2C+A&rft.aulast=Brown&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Abuse+and+Violence+During+Home+Care+Work+as+Predictor+of+Worker+Depression&rft.title=Abuse+and+Violence+During+Home+Care+Work+as+Predictor+of+Worker+Depression&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Methods to Characterize Diesel Particulate Matter in Occupational Settings AN - 19390608; 7157371 AB - Exposure of workers to diesel particulate matter (DPM) is gaining attention due to the growing amount of evidence that DPM can cause both short and long-term adverse health effects. NIOSH Researchers have developed an engine exhaust emission measurement laboratory to allow the characterization of diesel particulate matter in an occupational setting. This laboratory will enable researchers to characterize fine and nano-sized particles emitted from both modern and older diesel engines operating with and without diesel emission control technologies. This work is part of a large NORA effort in the area of ultra-fines research. Work to this point has shown that the use of certain control technologies can increase the concentration of nano-particles in the workplace air. The knowledge gained through this research will assist the medical community in gaining an increased understanding of the health risks associated with exposure to diesel exhaust in the mining environment as well as in other occupational settings. Additionally, it will aid industry, labor, and government in the development of effective diesel control strategies thereby reducing the exposure of workers to DPM. This work is all part of a larger diesel emission control and measurement effort that is being done in conjunction with both a Coal Diesel Partnership and a Metal/Nonmetal Diesel Partnership, both of which involve industry and labor representation. Findings from this research will be disseminated through partnership meetings, workshops, peer-reviewed publications, and presentations. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Mischler, SE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Metals KW - Emission control KW - Particulates KW - Coal KW - Diesel engines KW - Occupational exposure KW - Exhaust emissions KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mischler%2C+SE&rft.aulast=Mischler&rft.aufirst=SE&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Methods+to+Characterize+Diesel+Particulate+Matter+in+Occupational+Settings&rft.title=Methods+to+Characterize+Diesel+Particulate+Matter+in+Occupational+Settings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Oil and Gas Extraction Industry: Recent Fatal Injury Data and Areas for Action AN - 19390580; 7157367 AB - The mining industry has long been one of the more hazardous industries in the country. In 2004 the Census of Fatal Occupational Injuries (CFOI) program reported that the rate of fatal injury in mining was 28,3 fatal work injuries per 100,000 workers or nearly seven times the rate for the average U.S. worker and the second highest among major industry sectors. While the dangers of coal mining and many other mining industries have been well documented, the oil and gas extraction industry has received less attention, even though over half (55 percent) of the fatalities in mining from 1993 through 2004 were related to the oil and gas extraction industry. The purpose of this session is to summarize current surveillance data on fatal injuries in the oil and gas extraction industry, with a look at some of the initiatives being formulated to address the issues revealed by the data. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Mode, NA AU - Frederick, J R AU - Richardson, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Accidents KW - Injuries KW - Oil and gas industry KW - Occupational safety KW - Coal KW - extraction KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mode%2C+NA%3BFrederick%2C+J+R%3BRichardson%2C+S&rft.aulast=Mode&rft.aufirst=NA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Oil+and+Gas+Extraction+Industry%3A+Recent+Fatal+Injury+Data+and+Areas+for+Action&rft.title=The+Oil+and+Gas+Extraction+Industry%3A+Recent+Fatal+Injury+Data+and+Areas+for+Action&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Occupational Violence: Incidence, Consequences and Identification of Risk Factors as a Basis for Prevention AN - 19390579; 7157383 AB - The purpose of this study was to identify the magnitude and consequences of and risk factors for the problem of work-related violence within a major occupational population. In particular, this enabled determination of the relation between work-related violence in a cohort of registered and licensed practical nurses and: 1) personal exposures; 2) environmental situations/exposures in the work environment; and 3) characteristics of others in the environment (other workers, patients, visitors). In this study, work-related violence was defined as the intentional use of physical force or emotional abuse, against an employee, that resulted in physical or emotional injury and consequences. This included physical and non-physical violence (threat, sexual harassment, and verbal abuse). Work-related events included any activities associated with the job or events that occurred in the work environment; work-related travel was included. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gerberich, S G AU - Church, T R AU - McGovern, P M AU - Hansen, HE AU - Nachreiner, N M AU - Geisser AU - Ryan, AD AU - Mongin, S J AU - Watt, G D AU - Jurek, A Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Occupational safety KW - prevention KW - Violence KW - nursing KW - Medical personnel KW - Working conditions KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gerberich%2C+S+G%3BChurch%2C+T+R%3BMcGovern%2C+P+M%3BHansen%2C+HE%3BNachreiner%2C+N+M%3BGeisser%3BRyan%2C+AD%3BMongin%2C+S+J%3BWatt%2C+G+D%3BJurek%2C+A&rft.aulast=Gerberich&rft.aufirst=S&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Violence%3A+Incidence%2C+Consequences+and+Identification+of+Risk+Factors+as+a+Basis+for+Prevention&rft.title=Occupational+Violence%3A+Incidence%2C+Consequences+and+Identification+of+Risk+Factors+as+a+Basis+for+Prevention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Closing the Loop from Science to Prevention - A NORA Research Initiative AN - 19390558; 7157378 AB - Occupational traumatic injuries affect all 130 million U.S. workers, regardless of their industry or occupation. Each day, an average of 15 U.S. workers are fatally injured. The leading causes of fatal occupational injury are motor vehicles, falls, and homicides, which account for nearly 3,000 worker deaths annually. Additionally, there are more than 4 million nonfatal occupational injuries each year. Despite gradual reductions of work-related injuries over the past several decades, occupational trauma remains a public health problem of significant proportion. Workplace injuries often affect workers in their prime, productive years, increasing their adverse effect on the involved families and communities, both socially and economically. The economic burden of occupational traumatic injuries rivals that of cancer and heart disease. As a result of the continuing toll of workplace trauma, NIOSH funded Occupational Traumatic Injuries: Closing the Loop from Science to Prevention as a NORA Research Initiative in fiscal year 2001. The overall objectives for the initiative are to: build on past NIOSH surveillance and research efforts in traumatic occupational injury to increase prevention impact; emphasize completing the Public Health Model to bring practical and effective prevention products to the workplace; and widely disseminate research results for application to worker protection programs. Through this NORA Initiative, NIOSH funded six projects which address various research priorities for occupational traumatic injury: three technology transfer projects and three intervention evaluation projects. The NIOSH Division of Safety Research, along with the Pittsburgh and Spokane Research Laboratories, each has projects funded through the Initiative. The projects were designed to be interdisciplinary and involve collaboration across NIOSH and with relevant stakeholders and industry partners. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Pizatella, T Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - homicide KW - Injuries KW - Motor vehicles KW - Occupational safety KW - Economics KW - prevention KW - Technology transfer KW - Side effects KW - Cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pizatella%2C+T&rft.aulast=Pizatella&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Closing+the+Loop+from+Science+to+Prevention+-+A+NORA+Research+Initiative&rft.title=Closing+the+Loop+from+Science+to+Prevention+-+A+NORA+Research+Initiative&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Thermal Stress of Firemen During Training in Realistic Conditions AN - 19390552; 7157313 AB - It seems a logical combination: fire fighters and heat. However, fire fighters are only 5% of their working time exposed to heat and flames. Wearing their thick protective clothing, this means that they are almost always very warm and during actual fire fighting they encounter additional problems of skin burns. In hot conditions this is accompanied by the sweat production as a potential risk for skin burns the so-called "steam burns." During realistic training, fire fighters are regularly exposed to high temperature environments. In these activities thermal, physical and mental stress can be (very) high. To study these risks on skin burns, we carried out measurements of various physical parameters during realistic training conditions. During various training sessions we recorded body core temperatures, skin and clothing temperatures, heart rate and in some cases relative humidity within the clothing. We collected data on four fire fighters each day over two (separate) weeks without interfering with their training. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - DenHartog, E A AU - Heus, R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Protective clothing KW - Skin KW - Training KW - heart rate KW - Temperature KW - Heat tolerance KW - Steam KW - Stress KW - Humidity KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=DenHartog%2C+E+A%3BHeus%2C+R&rft.aulast=DenHartog&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Thermal+Stress+of+Firemen+During+Training+in+Realistic+Conditions&rft.title=Thermal+Stress+of+Firemen+During+Training+in+Realistic+Conditions&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Using Workplace Medical Surveillance to Evaluate A New Preventive Program in the Beryllium Industry: A Model for The Manufacturing Sector AN - 19390528; 7157363 AB - As many as 130,000 U.S. workers are exposed to beryllium and potentially at risk for chronic beryllium disease (CBD), an immune-mediated granulomatous lung disease. The blood beryllium lymphocyte proliferation test (BeLPT) detects beryllium sensitization, identifying workers at higher risk for CBD. Prevention of sensitization and CBD has traditionally emphasized engineering controls to maintain airborne beryllium levels below the Permissible Exposure Limit (PEL) of 2 square g/m3. A beryllium ceramics manufacturing facility initially focused preventive efforts on engineering controls such as enclosing machines and augmenting exhaust ventilation. Yet a 1998 survey of the facility's current workers showed 10% (15/151) were sensitized and 3% (5/151) had CBD. A new preventive program, stressing administrative controls and personal protective equipment (PPE) in addition to further engineering controls, was subsequently established from 1998-2000. In 2000, medical surveillance was initiated for early identification of prevention failures, allowing ongoing evaluation of the preventive program. We aimed to determine the effectiveness of the new preventive program and the impact of medical surveillance on its content. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Cummings, K J AU - Schuler, C R AU - Deubner, D C Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Ceramics KW - Blood KW - USA KW - Ventilation KW - Lung KW - Beryllium KW - prevention KW - Lymphocytes KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cummings%2C+K+J%3BSchuler%2C+C+R%3BDeubner%2C+D+C&rft.aulast=Cummings&rft.aufirst=K&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Using+Workplace+Medical+Surveillance+to+Evaluate+A+New+Preventive+Program+in+the+Beryllium+Industry%3A+A+Model+for+The+Manufacturing+Sector&rft.title=Using+Workplace+Medical+Surveillance+to+Evaluate+A+New+Preventive+Program+in+the+Beryllium+Industry%3A+A+Model+for+The+Manufacturing+Sector&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Prioritizing Industries for Occupational Injury and Illness Research and Prevention AN - 19390518; 7157302 AB - Broad Purpose: Provide information to Washington State occupational safety and health stakeholders and policy makers to make informed decisions about directing occupational safety and health resources. Objective: Identify high risk industry groups for occupational safety and health prevention and research activities. Methods: We used all compensable Washington State workers' compensation claims for a seven year time period, 1998-2004, to rank North American Industry Classification System (NAICS) industry groups according to the 'Prevention Index' (PI). The PI is the average of the rank orders of an industry group's claim count and claim incidence rate. Industries were also ranked by PI for seven common high cost compensable workers' compensation claims. Results: Of the 274 NAICS industry groups ranked by PI, these NAICS industry groups (4-digit NAICS) ranked the highest by Prevention Index: Foundation, Structure, & Building Exterior Contractors; General Freight Trucking, Couriers, Residential Building Construction, Scheduled Air Transportation, Building Finishing Contractors, Specialized Freight Trucking, Waste Collection, Psychiatric & Substance Abuse Hospitals, and Grocery & Related Product Wholesalers. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Bonauto, D AU - Silverstein, B AU - Adams, D AU - Foley, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - substance abuse KW - USA, Washington KW - Transportation KW - Housing KW - Occupational safety KW - prevention KW - Residential areas KW - Construction industry wastes KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bonauto%2C+D%3BSilverstein%2C+B%3BAdams%2C+D%3BFoley%2C+M&rft.aulast=Bonauto&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Prioritizing+Industries+for+Occupational+Injury+and+Illness+Research+and+Prevention&rft.title=Prioritizing+Industries+for+Occupational+Injury+and+Illness+Research+and+Prevention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Machine Safety in Small Metal Fabrication Businesses AN - 19390504; 7157360 AB - Importance of Problem: Metalworking has been identified as an industry with one of the highest rates of non-fatal injury in the United States. Hand injuries and finger amputations are an ongoing cause of disability. However, the systematic evaluation of machine related hazards is lacking. Purpose: The Minnesota Machine Guarding Study will evaluate the effectiveness of a peer-based technical and educational intervention designed to reduce exposure to amputation hazards among workers in small machining/metal working businesses. The baseline data presented here provide a profile of machine guarding in small (5-100 employees) metal fabrication businesses in Minnesota. Methods: We developed a set of scorecards to quantify machine-guarding practices. Up to 25 randomly selected machines were evaluated in each facility. In addition, audits were conducted to assess machine-related safety practices and programs (e.g., lock out - tag out). To compute a machine safety score, each scorecard item (e.g., barrier guard) was assigned a priority of one (high; e.g., emergency stops), two (medium; e.g., strain relief on electrical wires) or three (low; e.g., yellow color on the guards) to reflect both the probability and severity of injury. The number of scorecard items and items in each priority group varied by the type and complexity of the machine. Results: A total of 824 machines in 40 shops were assessed, the majority of which were milling, drilling and boring machines (33%) or presses (31%). Shops had an average of 37 machines (SD = 27, range 5 -100) and 15 shops had fewer than 25 machines. Overall we found that 55% (SD = 11%) of items addressing machine guarding were present, 39% (SD = 11%) were absent, and 6.4% (SD = 4.1%) could not be assessed. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Parker, D L AU - Samant, Y AU - Brosseau, L AU - Pan, W AU - Xi, M AU - Haugan, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Accidents KW - Injuries KW - disabilities KW - Machinery KW - Occupational safety KW - Metal industry KW - USA, Minnesota KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Parker%2C+D+L%3BSamant%2C+Y%3BBrosseau%2C+L%3BPan%2C+W%3BXi%2C+M%3BHaugan%2C+D&rft.aulast=Parker&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Machine+Safety+in+Small+Metal+Fabrication+Businesses&rft.title=Machine+Safety+in+Small+Metal+Fabrication+Businesses&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Early Predictors of Work Disability Associated with Carpal Tunnel Syndrome: A Longitudinal, Population-Based Workers' Compensation Cohort Study AN - 19390476; 7157300 AB - Work-related upper extremity musculoskeletal disorders such as carpal tunnel syndrome (CTS) are associated with high rates of chronic work disability and substantial costs relative to other work injuries. A minority of workers account for a large proportion of the costs. If workers at high risk for chronic disability could be identified early, they could be targeted for special treatment. The identification of modifiable risk factors could also guide treatment to address those factors. We therefore assessed worker and job characteristics early after submission of claims for CTS-related work disability to identify predictors of work disability one year later. We examined whether worker job perceptions and job physical demands predicted work disability after controlling for demographics and CTS symptom severity/functional limitations. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Turner, JA AU - Franklin, G AU - Wu, R AU - Fulton-Kehoe, D AU - Gluck, J AU - Sheppard, L AU - Egan, K AU - Wickizer, T Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - disabilities KW - Injuries KW - Perception KW - carpal tunnel syndrome KW - overuse injuries KW - Economics KW - musculoskeletal system KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Turner%2C+JA%3BFranklin%2C+G%3BWu%2C+R%3BFulton-Kehoe%2C+D%3BGluck%2C+J%3BSheppard%2C+L%3BEgan%2C+K%3BWickizer%2C+T&rft.aulast=Turner&rft.aufirst=JA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Early+Predictors+of+Work+Disability+Associated+with+Carpal+Tunnel+Syndrome%3A+A+Longitudinal%2C+Population-Based+Workers%27+Compensation+Cohort+Study&rft.title=Early+Predictors+of+Work+Disability+Associated+with+Carpal+Tunnel+Syndrome%3A+A+Longitudinal%2C+Population-Based+Workers%27+Compensation+Cohort+Study&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Measurement of Grip and Push Forces Applied to Vibrating Tools Using a Psychophysical Force-Recall Technique AN - 19390472; 7157343 AB - Operators of powered, vibratory hand tools are at risk of developing health problems associated with repeated forceful actions and exposure to intense hand-transmitted vibration. Carpal tunnel syndrome (CTS), hand/wrist tendonitis, hand-arm vibration syndrome (HAVS), and other hand-arm system disorders have been associated with foreceful hand action in combination with awkward postures and repetitive motions. To better assess health risks, comprehensive risk evalution of these tasks must include quantitative assessments of hand-tool coupling forces; however, no standardized method for quantifying hand forces exists. In this study, the effects of vibration and other factors on the accuracy of a psychophysical force-recall technique were explored in two experiments. Twelve male subjects participated in the first experiment. The second experiment employed 20 participants (10 female, 10 male). In each experiment, participants applied specific grip and push forces to an instrumented handle mounted on a shaker system. Participants were exposed to sinusoidal vibration at frequencies that ranged from 0 Hz to 250 Hz. Three levels of applied force (grip=30 plus or minus 15 N; push=50 plus or minus 25 N) and two levels of vibration magnitude were examined. During the vibration exposure period, participants were provided with visual feedback while they attempted to "memorize" the applied grip and push forces. At the conclusion of the vibration exposure/ force memorization period and a controlled rest period, the participants tried to duplicate the grip and push forces without the aid of visual feedback. The effects of different vibration frequencies, vibration magnitudes, and grip and push force levels were tested in a random order from trial to trial. To evaluate test-retest reliability, the test was repeated on a later day with each participant. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - McDowell, T W AU - Wiker, S F AU - Dong, R G AU - Welcome, DE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Vibration KW - carpal tunnel syndrome KW - overuse injuries KW - hand-arm vibration syndrome KW - Ergonomics KW - Occupational exposure KW - hand tools KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McDowell%2C+T+W%3BWiker%2C+S+F%3BDong%2C+R+G%3BWelcome%2C+DE&rft.aulast=McDowell&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Measurement+of+Grip+and+Push+Forces+Applied+to+Vibrating+Tools+Using+a+Psychophysical+Force-Recall+Technique&rft.title=The+Measurement+of+Grip+and+Push+Forces+Applied+to+Vibrating+Tools+Using+a+Psychophysical+Force-Recall+Technique&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Workers' Compensation Benefits Adequacy, Equity and Benefits Costs: Evidence from Canada on Two Approaches to Compensation for Permanent Impairment AN - 19390448; 7157296 AB - Importance of Research: Work disability is one of the most costly and prevalent health issues in North America, yet few studies have investigated the labor-market earnings recovery of individuals who have sustained permanent impairments from work accidents. Fewer still have investigated the adequacy, equity, and cost of wage-loss compensation provided by workers' compensation. In this study we investigate these issues using two samples of individuals sustaining a permanent impairment from a work accident and receiving benefits from two markedly different permanent disability programs in Ontario. The older program is a single benefit, impairment-based pension program. The more recent program is a dual award program that provides benefits based on loss of earnings capacity, and a non-economic loss award for pain, suffering and loss of enjoyment of life based on a permanent impairment rating. Study Objectives: There are three related objectives in this study: 1) to determine whether there are significant differences in labor-market earnings experiences post-accident between individuals receiving benefits from an impairment-based benefits program and a loss of earnings capacity based benefits program; 2) to evaluate the adequacy and equity of benefits provided by the two programs; and 3) to compare the relative cost of providing benefits based on the two approaches to benefits determination. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Tompa, E AU - Mustard, C AU - Sinclair, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - Accidents KW - disabilities KW - Occupational safety KW - pain KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Tompa%2C+E%3BMustard%2C+C%3BSinclair%2C+S&rft.aulast=Tompa&rft.aufirst=E&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Workers%27+Compensation+Benefits+Adequacy%2C+Equity+and+Benefits+Costs%3A+Evidence+from+Canada+on+Two+Approaches+to+Compensation+for+Permanent+Impairment&rft.title=Workers%27+Compensation+Benefits+Adequacy%2C+Equity+and+Benefits+Costs%3A+Evidence+from+Canada+on+Two+Approaches+to+Compensation+for+Permanent+Impairment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Antecedents of Youth Work Injury: A Prospective Study AN - 19390421; 7157328 AB - Importance of Research and Study Objectives: Adolescent and young adult workers are a particularly vulnerable population, with consistently higher rates of nonfatal occupational injuries than older individuals. Complicating the identification of risk factors is the heterogeneity of jobs young people hold and the multiple job transitions both young men and women experience early in their work careers. The purpose of this study is to examine the relative contribution of individual factors (e.g., gender), job characteristics (e.g., job type) and temporal factors (e.g., job tenure) to the likelihood of lost days of work due to a work disability (i.e., work disability absence) among adolescents and young adults. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Breslin, F C AU - Pole, J D AU - Tompa, E AU - Amick, B AU - Smith, P AU - Hogg-Johnson, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - disabilities KW - Injuries KW - Gender KW - Occupational safety KW - Adolescents KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Breslin%2C+F+C%3BPole%2C+J+D%3BTompa%2C+E%3BAmick%2C+B%3BSmith%2C+P%3BHogg-Johnson%2C+S&rft.aulast=Breslin&rft.aufirst=F&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Antecedents+of+Youth+Work+Injury%3A+A+Prospective+Study&rft.title=Antecedents+of+Youth+Work+Injury%3A+A+Prospective+Study&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Longitudinal Relationship of Extended Work Schedules to Musculoskeletal Problems in Nurses AN - 19390417; 7157284 AB - Importance: Nurses are at high risk for work-related musculoskeletal injury/disorders (MSD). Because of the movement by health care organizations to reduce costs, generally by downsizing the nursing workforce, the occurrence of unhealthy scheduling practices has been increasing. Purpose: Therefore, the purpose of this study was to examine the relationship of extended work schedules in nurses to the incidence of MSD. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Trinkoff, A AU - Geiger-Brown, J AU - Brady, B AU - Lipscomb, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Health care KW - Injuries KW - Occupational safety KW - nursing KW - Medical personnel KW - musculoskeletal system KW - working conditions KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Trinkoff%2C+A%3BGeiger-Brown%2C+J%3BBrady%2C+B%3BLipscomb%2C+J&rft.aulast=Trinkoff&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Longitudinal+Relationship+of+Extended+Work+Schedules+to+Musculoskeletal+Problems+in+Nurses&rft.title=The+Longitudinal+Relationship+of+Extended+Work+Schedules+to+Musculoskeletal+Problems+in+Nurses&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - World Trade Center Evacuation Study: Preliminary Findings AN - 19390389; 7157325 AB - Purpose: This CDC-funded study was designed to identify the individual, organizational, and environmental (building) factors that affected the evacuation from the Work Trade Center Towers (WTC) 1 and 2 on September 11, 2001. The overarching purpose of this study was to inform policy and practice with respect to evacuation of employees from high rise occupancies. Design: This recently completed three-year, five-phase study utilized both qualitative and quantitative data collection methodologies. A convenience sample of evacuees was recruited after recreating the master sample frame of approximately 500 employers leasing space at the WTC 1 and 2. Approximately 10% of the 15,000 employees who were at work on September 11,2001 participated in this study (N = 1767, of whom 1435 actually evacuated the building). The study questionnaire, available as an on-line version or hard copy, included a new emergency preparedness safety climate scale. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gershon, R G AU - Qureshi, K AU - Sherman, M F Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - World Trade Center KW - Health & Safety Science Abstracts KW - USA, New York, New York KW - Data collection KW - terrorism KW - safety engineering KW - Emergency preparedness KW - evacuation KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gershon%2C+R+G%3BQureshi%2C+K%3BSherman%2C+M+F&rft.aulast=Gershon&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Evacuation+Study%3A+Preliminary+Findings&rft.title=World+Trade+Center+Evacuation+Study%3A+Preliminary+Findings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Single Nucleotide Polymorphisms (SNPs) Associated with Decline in Lung Function in Firefighters AN - 19390363; 7157316 AB - Firefighters are routinely exposed to respiratory toxicants, including smoke. While assiduous use of respiratory protection has resulted in improvements in pulmonary function compared with historical findings, there are still many firefighters who experience an accelerated rate of decline in lung function, defined as a decline in forced expiratory volume in one second (FEV1) exceeding 60 ml/yr, averaged over a minimum of 5 years. Understanding factors associated with increased loss of lung function should help determine the best means of prevention. Our study objectives were to assess the evidence for genetic involvement in the rate of lung function decline in a population of firefighters. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kurzius-Spencer, M AU - Yucesoy, B AU - Guerra, S AU - Kashon, M L AU - Johnson, V J AU - Luster, MI AU - Burgess, J L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Smoke KW - Historical account KW - firefighter services KW - Toxicants KW - prevention KW - Respiratory function KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kurzius-Spencer%2C+M%3BYucesoy%2C+B%3BGuerra%2C+S%3BKashon%2C+M+L%3BJohnson%2C+V+J%3BLuster%2C+MI%3BBurgess%2C+J+L&rft.aulast=Kurzius-Spencer&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Single+Nucleotide+Polymorphisms+%28SNPs%29+Associated+with+Decline+in+Lung+Function+in+Firefighters&rft.title=Single+Nucleotide+Polymorphisms+%28SNPs%29+Associated+with+Decline+in+Lung+Function+in+Firefighters&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Hazard Surveillance - Development and Evaluation of Tools and Methods for a National Survey AN - 19390346; 7157303 AB - Current hazard surveillance data on the magnitude and distribution of workplace hazards, use of exposure controls, and management and worker health and safety practices, by facility type and size are lacking for all NORA industry sectors. If available, this information could be used for self-assessment, benchmarking and setting priorities for targeted research studies and intervention efforts. The feasibility of collecting self-reported surveillance information on health and safety (H&S) hazards from workers in a national establishment-based survey was evaluated by pilot testing web-based and paper modes and selected survey distribution protocols within the health services sector (NAICS 62). Feasibility was evaluated in terms of response rates, data quality, employer burden and logistical considerations. Successful survey methods, tools and data dissemination could serve as a model for other industry sectors. In this pilot study, meetings with healthcare stakeholders identified H&S issues of concern and interest, specific types of data to collect, preferred survey instrument modes, and ultimate uses of the data. Based on this information, employee and management questionnaires were developed and refined via cognitive testing by front-line healthcare workers and managers. The employee questionnaire consists of a core module (to be completed by all employees) addressing broad-based healthcare issues (e.g., stress, violence, work hours) and ten targeted hazard modules addressing selected chemical agents (hazardous drugs, aerosolized medications, high-level disinfectants, chemical sterilants, anesthetic gases, surgical smoke and cleaning agents). The employee questionnaire was available both on the web and in paper format. The management questionnaire (one per facility, paper only) elicits information about facility-wide H&S resources, programs, policies, and practices relative to the broad-based and targeted hazards included in the employee questionnaire. The paper questionnaire consisted of separate modules; the web version is seamless with respect to the modules. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Boiano, J M AU - Piacitelli, G M AU - Catalano, J D AU - Heyer, N AU - Payne, B AU - Sieber, W K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Feasibility studies KW - Smoke KW - Hazards KW - Disinfectants KW - Gases KW - Health care KW - Stress KW - Violence KW - Drugs KW - Occupational exposure KW - Medical personnel KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Boiano%2C+J+M%3BPiacitelli%2C+G+M%3BCatalano%2C+J+D%3BHeyer%2C+N%3BPayne%2C+B%3BSieber%2C+W+K&rft.aulast=Boiano&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hazard+Surveillance+-+Development+and+Evaluation+of+Tools+and+Methods+for+a+National+Survey&rft.title=Hazard+Surveillance+-+Development+and+Evaluation+of+Tools+and+Methods+for+a+National+Survey&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Health Services Utilization Among Hispanic Construction Workers AN - 19390339; 7157269 AB - In light of demographic changes in the United States, the construction industry is characterized by a large, young, and quickly growing Hispanic workforce, coupled with a sizable and persistent difference in occupational fatalities between Hispanic and non-Hispanic construction workers. Protecting safety and health of Hispanic workers is a critical challenge facing the construction industry. To address the NIOSH research priorities and examine this important focus area in construction safety and health research, we conducted targeted health services research on Hispanic construction workers using national survey data. The specific aims of this project include: 1) examine health status and health services utilization among Hispanic construction workers; 2) identify disparities in health and health services utilization between Hispanic construction workers and their white, no-Hispanic counterparts; 3) identify major socioeconomic and work organization factors underlining the disparities; and 4) develop intervention strategies to reduce/eliminate the disparities and improve health of Hispanic construction workers and the entire construction workforce as well. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dong, X Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Health care KW - Socioeconomics KW - Ethnic groups KW - Construction industry KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dong%2C+X&rft.aulast=Dong&rft.aufirst=X&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+Services+Utilization+Among+Hispanic+Construction+Workers&rft.title=Health+Services+Utilization+Among+Hispanic+Construction+Workers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Development and Implementation of a Model Surveillance System for Health Care Workers AN - 19390314; 7157288 AB - Workers in the health care industry may be exposed to a variety of work related stressors including infectious, chemical, and physical agents; ergonomic hazards; psychological hazards; and workplace violence. In addition, workplace and personal risk factors may act in combination to increase or exacerbate risks. The primary objective of this project was to develop and implement a model system for surveillance of potential exposures and health outcomes among health care and related employees. A surveillance system was developed which maximizes use of existing data sources and current coding schemes for important variables such as departments, jobs, and work locations. Workers' compensation claims, health insurance claims, health risk appraisals, and population-based surveys provide the primary health outcome data in the system. Exposures are defined by job and work location. The system can be viewed as a `data warehouse', consisting of risk factor and health outcome data tables which can be linked to extract individual level variables of interest to form specific analysis datasets. The major surveillance system data elements are updated at least annually, more frequently if needed for specific projects, and provide for cross-sectional and longitudinal analyses to identify populations at risk and to evaluate intervention and prevention programs. Examples of analyses using data from the surveillance system are presented including: 1) risk factors for blood and body fluid (BBF) exposures and 2) work-related stress and personal risk factors as predictors of health care utilization. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dement, J M AU - Lipscomb, HJ AU - Pompeii, L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - workers' compensation KW - Blood KW - Health care KW - Psychology KW - prevention KW - Violence KW - Insurance KW - Medical personnel KW - working conditions KW - Ergonomics KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dement%2C+J+M%3BLipscomb%2C+HJ%3BPompeii%2C+L&rft.aulast=Dement&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Development+and+Implementation+of+a+Model+Surveillance+System+for+Health+Care+Workers&rft.title=Development+and+Implementation+of+a+Model+Surveillance+System+for+Health+Care+Workers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Safety Risks in Modular Home Construction AN - 19390296; 7157281 AB - Broad Importance of the Research Problem: The process of installing (setting) a modular home is an entirely different process from that of a traditional stick-built house. The safety hazards that are created from these activities alone create a high hazard site. Of all of the industrialized housing market segments, modular home production has seen the greatest growth, although it currently holds the smallest percentage. Of particular interest is that modular homes were used extensively in rebuilding efforts of the Gulf Coast. Modular building production is not exclusive to residential construction. Modular manufacturers build everything from storage outbuildings to large hotel resorts. Purpose or Objectives of the Study: While conducting safety training for a modular home installer, researchers recognized the unique and serious safety hazards involving modular home installations. The purpose of this study on the installation of modular homes was to identify problems, make recommendations for improvement and suggest further research that is needed. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Takacs, B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - modular home construction KW - Health & Safety Science Abstracts; Risk Abstracts KW - Housing KW - Training KW - Occupational safety KW - Residential areas KW - Construction industry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Takacs%2C+B&rft.aulast=Takacs&rft.aufirst=B&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Safety+Risks+in+Modular+Home+Construction&rft.title=Safety+Risks+in+Modular+Home+Construction&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Economic Consequences of Serious Work-Related Injuries in British Columbia Sawmills AN - 19390295; 7157254 AB - Objective: The objective of this study is to estimate the costs of work-related injuries requiring hospitalisation in a cohort of sawmill workers in British Columbia and to determine the magnitude and proportion of these costs not paid for by the workers' compensation system. Methods: Hospital discharge records were extracted from 1989 to 1998 for a cohort of 5,876 actively employed sawmill workers. Injury cases were identified as work-related from these records using ICD-9 external cause of injury codes that indicate place of occurrence and the responsibility of payment schedule, which identifies workers' compensation as being responsible for payment. The workers' compensation claim records for these hospitalisations were extracted by matching injury and admission dates, and ICD-9 diagnosis codes. For each injury claim, comprehensive compensation costs data were collected for 7 years. For the uncompensated cases (work-related hospitalisations not linked with a claim), costs were imputed from the compensated cases using comparable types of injury. Costs for short term and long term disability and vocational rehabilitation were aggregated into non-healthcare costs. All costs were expressed in 1995 Canadian dollars using the provincial consumer price index and a 5% discounting rate (1 Canadian Dollar similar to 0.85 US Dollar). Costs were calculated from the workers' compensation system perspective. Results: Among 5,876 sawmill workers, there were 173 work-related injuries requiring hospitalisation during the ten-year follow-up period - an injury rate of 5.4/1,000 person years. Thirty-seven (21%) of these injuries did not match up with an accepted workers' compensation claim. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Alamgir, H AU - Tompa, E AU - Ostry, A AU - Koehoorn, M AU - Demers, P Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Canada, British Columbia KW - workers' compensation KW - Injuries KW - disabilities KW - Occupational safety KW - Economics KW - Lumber industry KW - Insurance KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Alamgir%2C+H%3BTompa%2C+E%3BOstry%2C+A%3BKoehoorn%2C+M%3BDemers%2C+P&rft.aulast=Alamgir&rft.aufirst=H&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Economic+Consequences+of+Serious+Work-Related+Injuries+in+British+Columbia+Sawmills&rft.title=Economic+Consequences+of+Serious+Work-Related+Injuries+in+British+Columbia+Sawmills&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Youth ATV Behavior AN - 19390283; 7157263 AB - ATV use is on the rise. With this increase in use comes a greater number of injuries involving ATVs. Nearly half of all injured ATV riders are under the age of sixteen. The estimated number of children injured in ATV-related incidents increased 94% from 1993 to 2001 and 95% of children that were injured were riding an ATV larger than recommended for their age. Over 2500 children are hospitalized each year due to ATV-related incidents which represents a 79% increase from 1997 to 2000. Approximately 1% of ATV-related hospitalizations resulted in death. Objective: The objective of this project was to increase adolescent awareness about the importance of wearing helmets, not allowing extra riders, and participating in training before operating ATVs. During a large national conference attend by rural and agricultural youth, we documented current training, helmet use, and behavior of youth using ATVs. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Burgus, S AU - Sanderson, W AU - Madsen, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - all terrain vehicles KW - Health & Safety Science Abstracts KW - Agriculture KW - Mortality KW - Behavior KW - Injuries KW - Training KW - Motor vehicles KW - helmets KW - Children KW - Adolescents KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Burgus%2C+S%3BSanderson%2C+W%3BMadsen%2C+M&rft.aulast=Burgus&rft.aufirst=S&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Youth+ATV+Behavior&rft.title=Youth+ATV+Behavior&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Cancer Incidence among Pesticide Applicators exposed to Trifluralin in the Agricultural Health Study AN - 19390253; 7157240 AB - Trifluralin, alpha , alpha , alpha -trifluoro-2,6-ninitro-N,N-dipropyl-p-toluidine, is a herbicide widely used to control annual grasses and broadleaf weeds in agricultural settings. Of 24,000 tons produced worldwide in 1998, about 64% was used on soybeans, and 19% was used on cotton. Although the U.S. EPA classified trifluralin as a possible human carcinogen, this classification is based entirely on animal studies as there have been no epidemiologic studies on the carcinogenic effects of trifluralin. The association between trifluralin use and common cancer incidence was evaluated among 50,127 private and commercial pesticide applicators in the Agricultural Health Study (AHS), a prospective cohort study of licensed pesticide applicators and their spouses in Iowa and North Carolina enrolled between 1993-7. Poisson regression was used to examine internal dose-response relationships, while controlling for important lifestyle factors and other agricultural exposures. Two metrics of exposure (lifetime days and intensity weighted lifetime days) were used in exposure- response analyses. The intensity weighted days accounts for differences in mixing and application practices which may influences total pesticide exposure. Both were examined using non-exposed applicators, as well as those in the lowest tertile of exposure, as the reference group. Incident cancers were identified through state tumor registries from enrollment in 1993 through 2002. Among private and commercial applicators, 51% (n=25,712) reported having ever used trifluralin. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kang, D AU - Park, S K AU - Beane-Freeman, L AU - Lynch, C F AU - Knott, CE AU - Sandler, D P AU - Hoppin, JA AU - Dosemeci, M AU - Coble, J AU - Lubin, J AU - Balir, A AU - Alavanja, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - USA, North Carolina KW - Cotton KW - Herbicides KW - Cancer KW - EPA KW - USA, Iowa KW - Carcinogenicity KW - Dose-response effects KW - Pesticides KW - Trifluralin KW - weeds KW - soybeans KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kang%2C+D%3BPark%2C+S+K%3BBeane-Freeman%2C+L%3BLynch%2C+C+F%3BKnott%2C+CE%3BSandler%2C+D+P%3BHoppin%2C+JA%3BDosemeci%2C+M%3BCoble%2C+J%3BLubin%2C+J%3BBalir%2C+A%3BAlavanja%2C+M&rft.aulast=Kang&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Cancer+Incidence+among+Pesticide+Applicators+exposed+to+Trifluralin+in+the+Agricultural+Health+Study&rft.title=Cancer+Incidence+among+Pesticide+Applicators+exposed+to+Trifluralin+in+the+Agricultural+Health+Study&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Assessing Heat Related Illness in Field Crop Workers in North Carolina AN - 19390231; 7157245 AB - North Carolina's excessively hot and humid summers challenge individuals to stay cool when working outside. Exposure to direct sun with limited convection and evaporation increases body heat production. Heat-related illness can range from minor to life threatening conditions. Agricultural field workers are especially vulnerable. Approximately 240 persons die of exertional heat-related disorders in the United States each year. Over the past several years in North Carolina, three reported events related to heat stroke have resulted in one Hispanic farm worker dying; one living in a vegetative state and returning to Mexico; and one who has recovered from his illness. Concerned by these reports of heat related illness, researchers from the N.C. Agromedicine Institute, located in Eastern North Carolina, along with a team of data collectors, conducted a study to assess the effects of environmental heat on the health status of farm workers, primarily Hispanic, in Eastern North Carolina. The study was funded jointly by the United States Department of Agriculture (USDA) and the National Institute for Occupational Safety and Health (NIOSH). This presentation will outline the study protocols and present study results including correlation of physiological data to environmental field conditions and variations in workers demographics and health status. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Sabella, J AU - Bernhart, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - USA, North Carolina KW - Evaporation KW - Occupational safety KW - Physiology KW - Heat tolerance KW - summer KW - Occupational exposure KW - Ethnic groups KW - Crops KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sabella%2C+J%3BBernhart%2C+J&rft.aulast=Sabella&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Assessing+Heat+Related+Illness+in+Field+Crop+Workers+in+North+Carolina&rft.title=Assessing+Heat+Related+Illness+in+Field+Crop+Workers+in+North+Carolina&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Prevention of Patient Violence in Health Care Settings AN - 19389490; 7157384 AB - Purpose of the Study: Research is needed to validate intervention programs to reduce violence by psychiatric patients. To that end, a Violence Prevention Community Meeting (VPCM) treatment program was introduced on an inpatient psychiatric unit and rates of assault were compared for Pre-Treatment, Treatment, and Post-Treatment periods. Methods: A protocol for conducting a Violence Prevention Community Meeting (VPCM) was designed by a panel of experts in patient violence, using a Delphi Approach to achieve consensus. The protocol had content validity and a structure that provided both focus and flexibility. The efficacy of the VPCM protocol was tested on an acute inpatient psychiatric unit in a Veterans Hospital over a 4-phase, 20-week period: Pre-Treatment (3 weeks), Transition (4 weeks), Treatment (9 weeks) where the VPCM was held twice weekly, Post-Treatment (4-weeks). The average patient census was 30 and average length of stay was 5 days. Patient Violence included verbal assault and actual or threatened physical violence. Every staff member on all three shifts carried a mechanical counter and recorded patient violence in "real time." Findings: Since data involved counts of incidents, analyses using the Poisson Model were undertaken. Wald Chi Square tests found significant (p<.01) reductions in violence incidents from Pre-Treatment to Treatment (30% reduction) and from Pre-Treatment to Post-Treatment (50% reduction). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Lanza, M AU - Rierdan, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - patient safety KW - Health & Safety Science Abstracts KW - Health care KW - Occupational safety KW - prevention KW - Violence KW - Working conditions KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lanza%2C+M%3BRierdan%2C+J&rft.aulast=Lanza&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Prevention+of+Patient+Violence+in+Health+Care+Settings&rft.title=Prevention+of+Patient+Violence+in+Health+Care+Settings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - International Evaluation of Injury Rates in Coal Mining: A Comparison of Risk and Compliance Based Regulatory Approaches AN - 19389476; 7157365 AB - In the United States (U.S.), the mining industry is largely governed by a complex framework of health and safety regulations administered through a compliance-based regulatory structure. In contrast to this conventional approach, the Australian mining industry began evaluating the merits of a regulatory system predicated upon risk management and analysis in 1992, followed by its formal adoption in Queensland (QLD) in 1999 and in New South Wales (NSW) in 2002. The primary objective of this study was to determine whether implementation of the risk management approach was temporally associated with a more rapid decline in lost time injuries (LTIs) than seen in the U.S. In 2003, injuries represented over 80% of all reported mining accident, injury and illness claims. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Poplin, G S AU - Miller, H D AU - Ranger-Moore, J AU - Bofinger, C M AU - Kunius-Spencer, M AU - Harris, R B AU - Burgess, J L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - USA KW - Accidents KW - Injuries KW - Australia, Queensland KW - Compliance KW - Occupational safety KW - Australia, New South Wales KW - safety regulations KW - Coal KW - Mining KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Poplin%2C+G+S%3BMiller%2C+H+D%3BRanger-Moore%2C+J%3BBofinger%2C+C+M%3BKunius-Spencer%2C+M%3BHarris%2C+R+B%3BBurgess%2C+J+L&rft.aulast=Poplin&rft.aufirst=G&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=International+Evaluation+of+Injury+Rates+in+Coal+Mining%3A+A+Comparison+of+Risk+and+Compliance+Based+Regulatory+Approaches&rft.title=International+Evaluation+of+Injury+Rates+in+Coal+Mining%3A+A+Comparison+of+Risk+and+Compliance+Based+Regulatory+Approaches&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Development of an Effective Beryllium Safety Model AN - 19389449; 7157364 AB - Broad Importance of the Research Problem: Beryllium contributes substantial benefits to society. Its unique physical properties allow beryllium to play a critical quality and reliability role in defense, safety, health and a variety of commercial applications. However, people continue to be diagnosed with clinical chronic beryllium disease (CBD). Surveillance has identified in some settingsadditional persons with sub-clinical CBD or who are beryllium sensitized (BeS). Purpose or Objectives of the Study: The study set out to define the workplace and personal susceptibility factors that contribute to CBD and BeS and to use this knowledge to develop, implement and evaluate an effective beryllium safety model. Summary of Findings: The prevalence surveys suggested that beryllium sensitization can be detected in the first months in employment, and that casual entry into beryllium workplaces, and migration of beryllium from beryllium work areas onto people and into other workplace areas, along with air level exposures above 0.2 mu g/m3 8h TWA, may contribute to elevated risk of CBD and BeS. A preventive model that incorporated features to address these issues was developed and implemented. Serial testing of workers hired since implementation show that BeS is being detected at a lower rate in these workers compared to prior experience. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Deubner, D C Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Beryllium KW - Working conditions KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Deubner%2C+D+C&rft.aulast=Deubner&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Development+of+an+Effective+Beryllium+Safety+Model&rft.title=Development+of+an+Effective+Beryllium+Safety+Model&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Relationship Between Work Organizational Factors, Physical Symptoms & Psychological Distress Two Years after the World Trade Center Terrorist Attacks AN - 19389421; 7157348 AB - Study Objective: To examine the relationship between organizational factors, workplace disaster-related crisis intervention programs and psychological distress as well as work productivity among employees exposed to a large-scale disaster in the work environment. The specific aims: 1) Identify the resources that were available to workers in the aftermath of the disaster, 2) assess how helpful these resources were to the workers 3) determine the prevalence of physical symptoms and psychological distress and their impact on work productivity two years after "9/11' and, 4) to explore the relationship between work organizational factors such as job-stress, workplace culture, disaster-related corporate programs, workers' physical health and psychological well-being. Results: Majority (86%) of the subjects were in good/excellent overall health and mental health. Persons who worked south of canal street (SOC) reported severe headache/migraine more frequently than those who worked north of Canal Street (NOC) (p=0.0202). Relative to other victims and non victims, primary victims reported severe headache/migraine and cough more frequently (p=0.0086 & 0.0043 respectively). Persons who worked in organizations with negative (aggressive defensive or passive defensive) cultures were 34% more likely to report cough compared to those who worked in organizations with a positive (constructive) culture (p =0.02). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Osinubi, OYO AU - Ohman, P AU - Ghandi, S AU - Fiedler, N AU - Robson, M AU - Kipen, H Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - World Trade Center KW - Health & Safety Science Abstracts KW - terrorism KW - Psychology KW - Disasters KW - emergency medical services KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Osinubi%2C+OYO%3BOhman%2C+P%3BGhandi%2C+S%3BFiedler%2C+N%3BRobson%2C+M%3BKipen%2C+H&rft.aulast=Osinubi&rft.aufirst=OYO&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Relationship+Between+Work+Organizational+Factors%2C+Physical+Symptoms+%26+Psychological+Distress+Two+Years+after+the+World+Trade+Center+Terrorist+Attacks&rft.title=The+Relationship+Between+Work+Organizational+Factors%2C+Physical+Symptoms+%26+Psychological+Distress+Two+Years+after+the+World+Trade+Center+Terrorist+Attacks&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Occupational Animal Exposure as a Predictor of Allergy and Asthma Prescription Drug Claims AN - 19389368; 7157310 AB - Research has shown that employees who work with animals are at risk of developing animal-induced occupational allergies and asthma. This study explores the possibility that occupational exposure to animals could have a measurable effect on health care use, specifically the prevalence of health insurance claims for allergy and asthma prescription drugs. The study population was comprised of employees at a large academic medical center, some of whom worked with research animals and all of whom were eligible for an employer-provided prescription drug benefit in 2003 (n=9,925). Data about prescription drug claims, employee demographics, job information, and occupational exposure to animals were extracted from a de-identified database that had been constructed for research purposes. Of all employees in the study population, 22% had at least one claim for allergy drugs, 10% had at least one claim for asthma drugs, 7% had occasional animal contact and 0.5% had daily animal contact. The effect of occasional and daily animal exposure on the number of allergy and asthma drug claims was estimated using two ordered probit regressions, which can be used when the dependent variable contains a small number of ordered categories. Three levels were used for asthma drugs (0,1, and 2 or more), and four levels were used for the more pervasive allergy drugs (0, 1,2, and 3 or more). Control variables included age, race, gender, and broad job categories (service/maintenance and clerical). JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Stanion, C V Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Animals KW - Health care KW - Gender KW - Asthma KW - Respiratory diseases KW - Drugs KW - Allergies KW - Insurance KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stanion%2C+C+V&rft.aulast=Stanion&rft.aufirst=C&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Animal+Exposure+as+a+Predictor+of+Allergy+and+Asthma+Prescription+Drug+Claims&rft.title=Occupational+Animal+Exposure+as+a+Predictor+of+Allergy+and+Asthma+Prescription+Drug+Claims&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Need for Workplace Surveillance for Occult Workplace Hypertension AN - 19389338; 7157304 AB - There is a large body of empirical evidence implicating workplace exposures (particularly work stressors) in the etiology of hypertension and ischemic heart disease (IHD). The theoretical constructs of how workplace factors affect the development of hypertension and IHD, together with a rich store of mediating biological mechanisms by which work stressors are perceived and processed by the central nervous system, and can lead to cardio-deleterious changes, provide convergent validation for the conclusion that workplace stressors play an important role in the development of these cardiovascular diseases (CVD). An outgrowth of this understanding of the work-related etiology of hypertension is the importance of assessing cardiovascular function during work. Thus, in contradistinction to well-known entities such as "white-coat" hypertension, the prognostically important finding of Occult Workplace Hypertension (elevated ambulatory blood pressure (AmBP) at work along with normal casual clinic blood pressure) is just beginning to attract clinical and research attention. Ambulatory (work time) blood pressure (AmBP) measurement is a more reliable and valid measure of true blood pressure than "casual" measurements taken in a clinic or doctor's office as it allows for more blood pressure determinations of individuals in real life circumstances. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Schnall, P AU - Landsbergis, P AU - Jauregui, M AU - Baker, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Central nervous system KW - Etiology KW - hypertension KW - Cardiovascular diseases KW - Blood pressure KW - Working conditions KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Schnall%2C+P%3BLandsbergis%2C+P%3BJauregui%2C+M%3BBaker%2C+D&rft.aulast=Schnall&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Need+for+Workplace+Surveillance+for+Occult+Workplace+Hypertension&rft.title=The+Need+for+Workplace+Surveillance+for+Occult+Workplace+Hypertension&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A New Approach to Field Evaluation of Hearing Protectors AN - 19389326; 7157393 AB - While hearing protection devices (HPD) have been the last line of defense against noise-induced hearing loss (NIHL) in the workplace, significant questions linger regarding their performance. HPD in use today do not provide the level of protection that would be expected from their laboratory evaluations under ANSI S3.19-1974 or S12.6-1997(R2001), with OSHA devaluing the laboratory rating by half in some applications, and NIOSH recommending deratings as high as seventy percent for some devices. One resolution of this issue is individual fit testing of HPD, where the performance of the HPD is tested on the individual user(s) of the devices. Several protocols have been developed to attempt this outcome; this presentation will address a modified microphone-in-real-ear (MIRE) approach called SonoPass that is software driven, field tested, and relatively quick to administer. The protocol measures noise reduction (simultaneous sound pressure levels inside and outside the HPD), and applies compensation factors derived from rigorous laboratory testing to provide personal attenuation equivalents, yielding an effective personal predicted attenuation rating, or P-PAR, for individual users. Comparison of SonoPass P-PAR findings and laboratory real ear attenuation at threshold (REAT) will be provided, demonstrating the reliability and utility of the SonoPass approach for determining HPD protection provided to the individual end user for a range of types and styles of HPD. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Hager, L AU - Voix, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Computer programs KW - Federal regulations KW - safety regulations KW - Noise reduction KW - Hearing loss KW - Occupational exposure KW - Sound pressure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hager%2C+L%3BVoix%2C+J&rft.aulast=Hager&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+New+Approach+to+Field+Evaluation+of+Hearing+Protectors&rft.title=A+New+Approach+to+Field+Evaluation+of+Hearing+Protectors&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Bloodborne Pathogen Risk in Home Healthcare Workers AN - 19389310; 7157293 AB - Background: Home health care workers (HHCWs) are at risk for a wide range of occupational health hazards, including bloodborne pathogen exposure, violence, and injury. This proposal is an extension of our previous pilot study of non-hospital-based healthcare workers, with a sample size of 1156 RNs, which included a subset of 72 HHCWs. Sixty-four percent (N=46) of the respondents reported one or more needlestick injuries during their careers. Forty percent of the needlesticks involved safety devices, despite 100% of RNs reporting having received training on such devices. Forty percent of HHCWs with a bloodborne pathogen exposure in the past year did not fill out an incident report and 60% were not seen by a health care professional. Purpose: The purpose of this four-year collaborative epidemiologic study of HHCWs is: to determine prevalence of blood/body fluid exposures; to characterize risk factors for exposure incidents and adverse mental health outcomes associated with exposures and post-exposure follow-up; to determine the availability and use of medical safety devices; to identify barriers to safe work practices; and to identify opportunities to reduce the risk of exposure in HHCWs using innovative participatory action research (PAR) teams. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Winnen, C W AU - Gershon, R G AU - Qureshi, K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Blood KW - Health care KW - Injuries KW - Training KW - Residential areas KW - Pathogens KW - Violence KW - Medical personnel KW - Occupational exposure KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Winnen%2C+C+W%3BGershon%2C+R+G%3BQureshi%2C+K&rft.aulast=Winnen&rft.aufirst=C&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Bloodborne+Pathogen+Risk+in+Home+Healthcare+Workers&rft.title=Bloodborne+Pathogen+Risk+in+Home+Healthcare+Workers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Hospital Noise: Characterization and Interventions that Work Long Term AN - 19389309; 7157389 AB - The purpose of the present study has been to characterize the noise environment in Johns Hopkins Hospital, to place our results in context geographically and historically, and to implement noise reduction strategies that will work long term. We have measured sound pressure levels in various units of Johns Hopkins Hospital using a precision sound level meter. This has produced sound levels as a function of location, time of day, and frequency. We have compared the results obtained to all similar results reported in the literature recently. We have also introduced two noise reduction strategies: the elimination of overhead paging through use of personal broadcast units, and the addition of hygienic sound absorption material. In both cases, we obtained objective measures of noise level reduction as well as survey data on perceived impact by staff and patients. Our results indicate that the level of noise in hospitals throughout the world has been rising about 0.4 decibels per year since 1960. The sound levels are now sufficiently high to be a concern in terms of sleep and speech interference. Further, the noise problem in hospitals seems universal -it does not vary much with geographic location or type of hospital. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Busch-Vishniac, I J AU - West, JE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Historical account KW - Absorption KW - Noise levels KW - Noise reduction KW - Occupational exposure KW - Hospitals KW - Sound pressure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Busch-Vishniac%2C+I+J%3BWest%2C+JE&rft.aulast=Busch-Vishniac&rft.aufirst=I&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hospital+Noise%3A+Characterization+and+Interventions+that+Work+Long+Term&rft.title=Hospital+Noise%3A+Characterization+and+Interventions+that+Work+Long+Term&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Risks for Workplace Violence in Long Haul Truckers AN - 19389286; 7157381 AB - Significance of problem: Seventeen workers are murdered and an estimated 33,000 workers experience a non-fatal assault in the U.S. each year (NIOSH, 2004). The transient nature of trucking increases the risk for experiencing workplace violence (Renner, 1998). Purpose: To investigate the incidence and distribution of workplace violence among long-haul truck drivers. Specific aims: (1) identify the types of violence experienced by long-haul truck drivers; (2) identify risk factors that contribute to the violence; (3) differentiate the risks of work-related stress among distinct socio-demographic groups of truckers; (4) determine the prevalence of domestic violence experienced by long-haul truck drivers; and (5) identify work environment factors that place truck drivers' at risk. Method: A quantitative survey has been conducted with a non-probability sample (N=987) recruited at truck shows and truck stops across the U.S. Data were collected on violence-related variables (e.g. harassment, weapons, assault, rape, worksite security, psychological strain, and substance abuse). Qualitative data on violence at the worksite is continuing to be collected via phone interviews with a purposive sample of 30 female and 30 male participants. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Anderson, D G AU - Reed, D B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - long haul truckers KW - Health & Safety Science Abstracts; Risk Abstracts KW - substance abuse KW - USA KW - Weapons KW - Psychology KW - Occupational safety KW - domestic violence KW - Trucks KW - security KW - Violence KW - Working conditions KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Anderson%2C+D+G%3BReed%2C+D+B&rft.aulast=Anderson&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Risks+for+Workplace+Violence+in+Long+Haul+Truckers&rft.title=Risks+for+Workplace+Violence+in+Long+Haul+Truckers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Factors Related to Healthcare Workers' Ability and Willingness to Report to Work During Catastrophic Disasters AN - 19389269; 7157282 AB - New emerging infectious diseases have the potential to create significant surge capacity needs across the U.S. healthcare system. Unlike the military, private sector healthcare workers (hcw) can rarely be forced to report to work. Understanding the factors that may influence a hew's choice as to whether or not to report to duty during a catastrophic disaster is important. We conducted a survey of staff from 47 hospitals, community health centers and long term facilities in the New York metropolitan region regarding their ability and willingness to report to duty during a variety of catastrophic events. This presentation will focus on these findings as well as results from secondary analysis of data from this same study. We found that ability and willingness to report to work varied by type of event, where hcw's were least willing to report to work for SARS events, and most willing to report during a snow storm, and most able to report during a mass casualty incident and least able during a snow storom. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Qureshi, K AU - Gershon, R M AU - Sherman, M F AU - Straub, T AU - Gebbie, E AU - McCollum, M AU - Tan, M AU - Morse, S S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Data processing KW - Snow KW - Disasters KW - decision making KW - Medical personnel KW - USA, New York KW - infectious diseases KW - Health care KW - Infectious diseases KW - Human factors KW - Military KW - SARS coronavirus KW - Emergency medical services KW - Hospitals KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Qureshi%2C+K%3BGershon%2C+R+M%3BSherman%2C+M+F%3BStraub%2C+T%3BGebbie%2C+E%3BMcCollum%2C+M%3BTan%2C+M%3BMorse%2C+S+S&rft.aulast=Qureshi&rft.aufirst=K&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Factors+Related+to+Healthcare+Workers%27+Ability+and+Willingness+to+Report+to+Work+During+Catastrophic+Disasters&rft.title=Factors+Related+to+Healthcare+Workers%27+Ability+and+Willingness+to+Report+to+Work+During+Catastrophic+Disasters&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Disseminating Research Products Based on Stakeholder Characteristics and Needs AN - 19389266; 7157377 AB - Noise induced hearing loss (NIHL) continues to be a problem in the mining industry. Hearing loss data suggests that by the age of 50, nearly 90% of coal miners have a hearing impairment, as compared to 10% for a general population of non-exposed males. The use of engineering controls as a way to lower noise exposure is the most desired among the hierarchy of controls to prevent NIHL. While integrating stakeholder involvement into the research and development is imperative to successful technology transfer efforts, often communicating this information is overlooked. This presentation will highlight stakeholder importance in the design and development of marketing and dissemination products. In partnership with stakeholders in the mining and surface drilling industries, NIOSH conducted research to develop engineering control technologies that reduces workplace noise exposure. Previous studies indicated that operators of non-cab surface drill rigs are overexposed to noise. These rigs are in use for the work of various surface drilling industries including mining and construction. Many surface rigs do not have full cabs as a result of the original equipment manufacturer design or the prohibitive cost of aftermarket products. NIOSH researchers determined that a noise engineering control to protect the operator at the rig's control panel would be effective based on the organization of work practices and typical worker behaviors. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Reinke, DCR AU - Yantek, DsY AU - Jurovcik, P J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Technology transfer KW - Noise reduction KW - Hearing loss KW - Coal KW - Working conditions KW - Occupational exposure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reinke%2C+DCR%3BYantek%2C+DsY%3BJurovcik%2C+P+J&rft.aulast=Reinke&rft.aufirst=DCR&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Disseminating+Research+Products+Based+on+Stakeholder+Characteristics+and+Needs&rft.title=Disseminating+Research+Products+Based+on+Stakeholder+Characteristics+and+Needs&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Workplace Solutions and Construction Solutions Databases: Web-based Hazard and Solution Information for the Small Business Community and Construction Industry AN - 19389246; 7157267 AB - Research to date has demonstrated the range of occupational hazards, characterized the levels of exposure for some specific workers and tasks, and validated some of the many available control strategies. Additionally, various efforts have been made to collect and disseminate information on new and innovative control technologies. The Workplace Solutions and Construction Solutions database projects will take the critical next step of organizing and presenting this information in a clear and simple web-based format easily-accessible to employers and workers. The goal of the Workplace Solutions internet site is to enhance the NIOSH small business resources site to transfer the results of current research, solution information and technology transfer information to small business workplaces. Information presented on the Workplace Solutions site will include hazard information, training materials and evidence-based solutions targeted to specific small business segments. The complimentary Construction Solutions site will present simple overviews of hazards and risks associated with core job tasks in fifteen different construction trade groups. For each task/hazard pair, the Construction Solutions database will identify and describe a range of currently-available solutions, including control technologies and techniques aimed at architects, manufacturers, contractors and workers. Where available, productivity and return-on-investment considerations will be included in solution information developed for both projects. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Entzel, P AU - Niemeier, R AU - Platner, J AU - Welch, L S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Hazards KW - Training KW - Technology transfer KW - Occupational exposure KW - Internet KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Entzel%2C+P%3BNiemeier%2C+R%3BPlatner%2C+J%3BWelch%2C+L+S&rft.aulast=Entzel&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Workplace+Solutions+and+Construction+Solutions+Databases%3A+Web-based+Hazard+and+Solution+Information+for+the+Small+Business+Community+and+Construction+Industry&rft.title=The+Workplace+Solutions+and+Construction+Solutions+Databases%3A+Web-based+Hazard+and+Solution+Information+for+the+Small+Business+Community+and+Construction+Industry&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Job Demands and Occupational Health Among Immigrant Poultry Processing Workers AN - 19389245; 7157354 AB - Workers in the poultry processing industry experience high rates of illness and injury. Estimates indicate that poultry processing ranks 3rd among over 700 industries in cumulative trauma disorders and 4th in terms of overall occupational illnesses. Despite these high rates, very little peer-reviewed research has documented the organizational and environmental factors contributing to variation in injury and illness among poultry processing workers. Importance of the Research Problem: Determining the organizational and environmental factors contributing to injury and illness among poultry workers is important for two reasons. First, it provides insight into potential strategies for protecting the health of poultry workers, either by redesigning how poultry is processed or policies that protect workers. Second, recognizing that poultry processing is increasingly reliant on the immigrant workforce, such research and subsequent interventions would assist in eliminating ethnic disparities in health. The Purpose of the Study: The goal of this study was to identify modifiable organizational and environmental factors associated with occupational illness and injury among workers in the poultry processing industry. To accomplish this goal, this study: 1) documented levels of physical and psychological demands reported by poultry workers, and 2) identified physical and psychological demands associated with recent symptoms of musculoskeletal problems, respiratory problems, and self-report injury or illness in the past year. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Grzywacz, J G AU - Arcury, T A AU - Coates, M L AU - Burke, B AU - Carrillo, L AU - Matin, A AU - Quandt, SA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - cumulative trauma disorders KW - poultry KW - Injuries KW - Psychology KW - immigrants KW - Respiratory function KW - Ethnic groups KW - musculoskeletal system KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Grzywacz%2C+J+G%3BArcury%2C+T+A%3BCoates%2C+M+L%3BBurke%2C+B%3BCarrillo%2C+L%3BMatin%2C+A%3BQuandt%2C+SA&rft.aulast=Grzywacz&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Job+Demands+and+Occupational+Health+Among+Immigrant+Poultry+Processing+Workers&rft.title=Job+Demands+and+Occupational+Health+Among+Immigrant+Poultry+Processing+Workers&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Pilot Study of Design Professionals' Perceived Feasibility of the Design for Construction Safety Intervention AN - 19389224; 7157266 AB - Research studies have identified the design of projects as being a significant contributing factor to construction site accidents. Designing to eliminate or avoid hazards prior to exposure on the jobsite is listed as the top priority in the hierarchy of controls common to the safety and health professions. Widespread implementation of the design for construction safety intervention in the U.S. by engineering and architecture firms, however, is lacking due to perceived industry and project barriers. Given its absence from standard design practice, a question arises as to the feasibility of designing for safety as a practical intervention in the construction industry. Design professionals are a key component in determining how this intervention can be most effectively utilized within the constraints of the U.S. construction industry. This research presents a pilot study that was conducted to investigate the practice of addressing construction worker safety when designing a project and to determine its feasibility and practicality. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gambatese, J AU - Behm, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Feasibility studies KW - USA KW - Accidents KW - safety engineering KW - Construction industry KW - Design KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gambatese%2C+J%3BBehm%2C+M&rft.aulast=Gambatese&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Pilot+Study+of+Design+Professionals%27+Perceived+Feasibility+of+the+Design+for+Construction+Safety+Intervention&rft.title=A+Pilot+Study+of+Design+Professionals%27+Perceived+Feasibility+of+the+Design+for+Construction+Safety+Intervention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Interactive and Participatory Training in Evaluation Methodology for Researchers and Practitioners in Occupational Safety and Health AN - 19389220; 7157350 AB - Translating workplace safety and health research into practice is a complicated process that is, for the most part, quite particular to the area of research and to the work environments to be changed. However, there are common tools and research strategies that can be used to assist researchers and practitioners in many different settings and circumstances to evaluate the changes, programs, or interventions they have devised to address particular problems in occupational safety and health. This poster reports the development of a participatory workshop that combines case studies focused on specific problems in occupational safety and health with generic research methodology. The purpose of the workshop is to help OSH researchers and practitioners develop a practical application of the generic research tools to their specific needs. The core of the workshop is based in the case studies which open the workshop. To date, 26 case studies have been developed in 9 topic areas: agriculture, construction, emergency response, ergonomics/musculoskeletal, migrant health care, mining, nursing, occupational medicine, and public health. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Scharf, T AU - Gilmore, K AU - Valosen, J AU - Kapeller, E AU - Bletzer, K AU - Kidd, P S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Health care KW - Training KW - Occupational safety KW - musculoskeletal system KW - Ergonomics KW - working conditions KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Scharf%2C+T%3BGilmore%2C+K%3BValosen%2C+J%3BKapeller%2C+E%3BBletzer%2C+K%3BKidd%2C+P+S&rft.aulast=Scharf&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Interactive+and+Participatory+Training+in+Evaluation+Methodology+for+Researchers+and+Practitioners+in+Occupational+Safety+and+Health&rft.title=Interactive+and+Participatory+Training+in+Evaluation+Methodology+for+Researchers+and+Practitioners+in+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Using a Software as an Exposure Assessment Device to Measure and Detect Computer Users' Muscle Fatigue AN - 19389195; 7157341 AB - The aim of this study was to determine whether changes in keystroke duration, which can be continuously and non-invasively measured by one's own computer, could be used as a surrogate to detect the computer user's muscle fatigue. We have developed a customized computer usage monitoring software to precisely record keystroke durations. If keystroke duration is related to muscle fatigue, then this software program, without additional instrumentation, would measure physiological changes of a user during exposure to computer work. As a step to developing such a measurement tool, the relationship between finger muscle fatigue and computer typing performance, specifically the keystroke durations recorded by the software, was tested in a laboratory study. The study tested the hypothesis that the keystroke duration during a typing task changes as the physiological changes of muscle. Our measure of muscle physiology was low frequency muscle fatigue, which has been associated with exposure to sub-maximal repetitive activities. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Chang, CH AU - Johnson, P W AU - Dennerlein, J T Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Computer programs KW - Overuse injuries KW - Physiology KW - Muscles KW - fatigue KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chang%2C+CH%3BJohnson%2C+P+W%3BDennerlein%2C+J+T&rft.aulast=Chang&rft.aufirst=CH&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Using+a+Software+as+an+Exposure+Assessment+Device+to+Measure+and+Detect+Computer+Users%27+Muscle+Fatigue&rft.title=Using+a+Software+as+an+Exposure+Assessment+Device+to+Measure+and+Detect+Computer+Users%27+Muscle+Fatigue&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Do Ergonomic Interventions for Shovels Effectively Mitigate Risk of Injury in Farm Kids? AN - 19389190; 7157264 AB - Background: Farming remains to be a significant and important industry sector in the United States' economy with respect to the number of workers, health hazards, and production. Another key component to the farming industry is the large number of youth who work in the industry and may need special considerations with respect to the development of low back disorders (LBDs). Farming is a physically demanding profession for both adult and youth farmers. Several researchers have identified a number of farming tasks as being risky for LBDs, which include shoveling, pushing wheelbarrows, weeding, handling animals, and lifting material. Youth may have an even greater risk of injury due to utilizing equipment designed for adult farmers. Purpose: The current study determined whether an "ergonomically" - designed intervention for shoveling was effective in reducing the risk of developing LBDs. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kotowski, S AU - Davis, K AU - Waters, T Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - shovels KW - Health & Safety Science Abstracts; Risk Abstracts KW - USA KW - Injuries KW - Man-machine interactions KW - Economics KW - lifting KW - Ergonomics KW - working conditions KW - Occupational health KW - Agricultural equipment KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kotowski%2C+S%3BDavis%2C+K%3BWaters%2C+T&rft.aulast=Kotowski&rft.aufirst=S&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Do+Ergonomic+Interventions+for+Shovels+Effectively+Mitigate+Risk+of+Injury+in+Farm+Kids%3F&rft.title=Do+Ergonomic+Interventions+for+Shovels+Effectively+Mitigate+Risk+of+Injury+in+Farm+Kids%3F&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Health and Safety in the Fields: Evaluation of a High School ESL Curriculum AN - 19389170; 7157249 AB - Children and adolescents working in agriculture face significant health and safety risks and experience work-related injuries and illnesses at a higher rate than youth working in other industries. Most research has focused on youth on family farms, and very little data is available on hired teens. This presentation will describe the findings of research carried out to evaluate a school-based intervention reaching hired teen farmworkers. Specifically, the intervention consisted of implementing a high school ESL curriculum designed to provide teen agricultural workers with the knowledge and tools to protect their health and safety in the fields. The specific aims of the study were to: 1) assess whether students who participated in the curriculum would demonstrate an increase in knowledge and improved attitudes and behaviors regarding health and safety, as compared to a comparison group; 2) assess whether a community-based intervention, in the form of workshops on health and safety for parents, would affect outcomes even further; and 3) explore and pilot other community-based outreach and education methods that could be successful in reaching teen farmworkers. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Baker, R AU - Teran, S AU - Strochlic, R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - Education KW - Injuries KW - farms KW - Children KW - Adolescents KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Baker%2C+R%3BTeran%2C+S%3BStrochlic%2C+R&rft.aulast=Baker&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+and+Safety+in+the+Fields%3A+Evaluation+of+a+High+School+ESL+Curriculum&rft.title=Health+and+Safety+in+the+Fields%3A+Evaluation+of+a+High+School+ESL+Curriculum&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - World Trade Center Evacuation Study: Preliminary Disability Data AN - 19389145; 7157326 AB - Purpose: Persons with disabilities (PWD) may be at increased risk of morbidity and mortality during emergency situations that require evacuation. In this study, designed to identify the individual, organizational, and environmental (building) factors that affected the evacuation from the Work Trade Center Towers (WTC) 1 and 2 on September 11, 2001, we examined the relationship between disabilities and the evacuation process. This information may be helpful to emergency planners. Design: The World Trade Center Evacuation Study (WTCES) utilized both qualitative and quantitative data collection methodologies. A convenience sample of evacuees was recruited; there were 1435 participants who evacuated either WTC 1 or WTC 2 on September 11, 2001. The study questionnaire, available as web-based or hard copy version, included a number of items that addressed disabilities, disability preparedness, and co-workers' awareness of disability planning for emergencies. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Rubin AU - Gershon, R G AU - Sherman, M F Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - World Trade Center KW - Health & Safety Science Abstracts KW - USA, New York, New York KW - Mortality KW - terrorism KW - Data collection KW - disabilities KW - Emergency preparedness KW - evacuation KW - Morbidity KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rubin%3BGershon%2C+R+G%3BSherman%2C+M+F&rft.aulast=Rubin&rft.aufirst=&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Evacuation+Study%3A+Preliminary+Disability+Data&rft.title=World+Trade+Center+Evacuation+Study%3A+Preliminary+Disability+Data&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Randomized Controlled Trial of Ergonomic Interventions in Computer Users AN - 19389130; 7157323 AB - Customer service work at computers is associated with elevated rates of upper body musculoskeletal disorders and pain. The purpose of this study was to determine whether two simple workstation interventions would reduce the incidence of upper body musculoskeletal disorders and pain severity among computer users. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Rempel, D AU - Krause, N AU - Goldberg, R AU - Benner, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - pain KW - musculoskeletal system KW - Ergonomics KW - working conditions KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Rempel%2C+D%3BKrause%2C+N%3BGoldberg%2C+R%3BBenner%2C+D&rft.aulast=Rempel&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Randomized+Controlled+Trial+of+Ergonomic+Interventions+in+Computer+Users&rft.title=A+Randomized+Controlled+Trial+of+Ergonomic+Interventions+in+Computer+Users&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Evaluation of State-Wide Emergency Department Data for Occupational Injury Surviellance AN - 19389116; 7157306 AB - State-wide databases of emergency department (ED) discharges now available in some states potentially provide useful information about the nature and extent of occupational injuries at state and local levels, augmenting surveillance data based on employer record-keeping. This study evaluated the feasibility of using electronic ED records reported to the state health department for occupational injury surveillance. Key aims were to: estimate the sensitivity and predictive value of two indicators of work-relatedness in the ED data; assess the availability of information about employer, industry and occupation in medical charts and the electronic data systems; and estimate the accuracy of external cause of injury codes (E-codes) for work-related injuries. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Davis, L K AU - Hunt, PR AU - Hackman, H AU - Ozonoff, V Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Occupational safety KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Davis%2C+L+K%3BHunt%2C+PR%3BHackman%2C+H%3BOzonoff%2C+V&rft.aulast=Davis&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+State-Wide+Emergency+Department+Data+for+Occupational+Injury+Surviellance&rft.title=Evaluation+of+State-Wide+Emergency+Department+Data+for+Occupational+Injury+Surviellance&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Enhanced Surveillance to Detect Severe Nonfatal Occupational Injuries AN - 19389090; 7157305 AB - Importance: Although there have been many studies of fatal occupational injuries, relatively few surveillance efforts have included the most severe nonfatal occupational injuries, including hospitalizations. Purpose: This project seeks to develop and evaluate a model surveillance system to identify the entire spectrum of injury severity occurring in occupational settings and describe the specific types of injury and their circumstances. The first step was the creation of a comprehensive database to examine the incidence of occupational injury statewide. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dischinger, P C AU - Auman, K M AU - Ho, S M AU - Braver, E R Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dischinger%2C+P+C%3BAuman%2C+K+M%3BHo%2C+S+M%3BBraver%2C+E+R&rft.aulast=Dischinger&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Enhanced+Surveillance+to+Detect+Severe+Nonfatal+Occupational+Injuries&rft.title=Enhanced+Surveillance+to+Detect+Severe+Nonfatal+Occupational+Injuries&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Validation and Reliability of a Checklist for Evaluating Cab Design Characteristics of Mobile Construction Equipment AN - 19389070; 7157278 AB - Operators of heavy mobile construction equipment often incur high rates of musculoskeletal disorders (MSDs). This is contributed to, in part, by exposure to awkward postures during the operation of the equipment which are a consequence of the design of the cab, location of controls, and work procedures. However, there is a lack of valid methods capable of describing postural stresses among these operators. The objectives of the study are: 1) to validate a cab design checklist by: a) collecting postural data among operators of ten different types of heavy construction equipment, b) analyzing postural data using video analysis, and c) assessing correlations between scores from the checklist and the postural analysis for specific joints; and 2) assess the reliability of the checklist by: a) collecting data using cab design checklist, and b) assessing the inter-rater reliability of the raters administrating the checklist. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kittusamy, N K AU - Aedla, P B AU - Jorgensen, MJ Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - cab design KW - Health & Safety Science Abstracts KW - Stress KW - Construction industry KW - musculoskeletal system KW - Design KW - Occupational health KW - posture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kittusamy%2C+N+K%3BAedla%2C+P+B%3BJorgensen%2C+MJ&rft.aulast=Kittusamy&rft.aufirst=N&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Validation+and+Reliability+of+a+Checklist+for+Evaluating+Cab+Design+Characteristics+of+Mobile+Construction+Equipment&rft.title=Validation+and+Reliability+of+a+Checklist+for+Evaluating+Cab+Design+Characteristics+of+Mobile+Construction+Equipment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Ag Safety Days AN - 19389054; 7157250 AB - Ag Safety Days is a series of safety training programs provided to the agricultural community. These programs are designed to satisfy OSHA and EPA regulations, but will also provide assistance to those operations that do not have employees. Topics covered range from chemical and pesticide safety, equipment safety, machinery safety, respirator training and fit-testing, 1st aid/CPR, portable fire extinguisher training, and other training as needed. In addition, assistance is provided on labor related issues. The primary goal of this program is to increase the capacity and knowledge of workplace safety within the agricultural community. Through this outreach program individuals are exposed to safety training and safety programs, often for this first time. This type of outreach activity is vital in generating interest in workplace safety. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Orr, LE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Agriculture KW - EPA KW - Federal regulations KW - Training KW - Machinery KW - Pesticides KW - safety regulations KW - Respirators KW - Protective equipment KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Orr%2C+LE&rft.aulast=Orr&rft.aufirst=LE&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ag+Safety+Days&rft.title=Ag+Safety+Days&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - From Noise Research to Preventive Practice on Work-Related Hearing Loss AN - 19389035; 7157395 AB - ISO 1999 and current U.S. noise standards were established using the results of a number of demographic studies done at least 30 years ago. The original noise standards reflected a reasonable synthesis of prevailing scientific understanding and had merit when they were first advanced. However, science has since produced important new insights into the relation between a subject's noise exposure and the resultant hearing loss. The ISO and Department of Labor standards were based on demographic studies of noise-induced hearing loss that are fundamentally limited by large intersubject variability. It is conceivable that the variability seen in hearing loss databases may be, in part, the result of organizing the diverse exposure conditions to which the subject population was exposed around the single descriptive metric; energy. In this presentation, the limitations of this approach and the alternative of using energy metric in combination with the statistical metrics of frequency- and time-domain kurtosis and the joint peak-interval histogram to evaluate any noise environment's potential for causing hearing loss are discussed. Moreover, the potential risk to hearing loss posed by chemical agents in the work place is addressed as well as the involvement of reactive oxygen species (ROS) as a common factor in these causes of sensory-neural hearing loss. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Henderson, D Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - USA KW - Hearing loss KW - Noise standards KW - Working conditions KW - Occupational exposure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Henderson%2C+D&rft.aulast=Henderson&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=From+Noise+Research+to+Preventive+Practice+on+Work-Related+Hearing+Loss&rft.title=From+Noise+Research+to+Preventive+Practice+on+Work-Related+Hearing+Loss&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Respiratory Protection against Bioaerosols in Agriculture AN - 19389031; 7157243 AB - Background: Agricultural workers can be exposed to high concentrations of airborne microorganisms and thus have an increased risk for developing respiratory diseases. Respirators, when properly selected and used, can decrease agricultural workers' exposure. Objective: In this study, a new field-compatible method was developed to dynamically measure the protection provided by respirators against dust and bioaerosols in agricultural environments. A pilot study was performed in agricultural environments to evaluate the method in field conditions. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Reponen, T AU - Lee, S-A AU - McKay, R AU - Shukla, R AU - Grinshpun, SA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Agriculture KW - Airborne microorganisms KW - Respiratory diseases KW - Agrochemicals KW - Protective equipment KW - Dust KW - Air pollution KW - Respirators KW - Occupational exposure KW - A 01450:Environmental Pollution & Waste Treatment KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Industrial+and+Applied+Microbiology+Abstracts+%28Microbiology+A%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Reponen%2C+T%3BLee%2C+S-A%3BMcKay%2C+R%3BShukla%2C+R%3BGrinshpun%2C+SA&rft.aulast=Reponen&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Respiratory+Protection+against+Bioaerosols+in+Agriculture&rft.title=Respiratory+Protection+against+Bioaerosols+in+Agriculture&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Predicting Potentiation of Noise-Induced Hearing Loss by Chemicals: Oxidative Stress as a Mechanism of Hearing Loss AN - 19389010; 7157392 AB - Laboratory animal studies as well as occupational epidemiological studies demonstrate that a broad range of chemical agents can increase the vulnerability of subjects to noise exposure. Consequently, under conditions of workplace exposure to specific chemicals, permanent hearing loss may occur even at permissible noise exposure levels. Predicting which chemicals can promote noise-induced hearing loss is essential both in establishing safe work conditions and developing potential treatment modalities for accidentally exposed workers. The objectives of this research are to determine the biological basis for the interaction between chemicals and noise in order to facilitate prediction of chemical agents that can promote noise-induced hearing loss. Specific chemical agents were selected based both upon their common use in occupational settings and their potential to produce oxidative stress. The specific hypothesis tested was that chemicals, which interfere with normal antioxidant pathways, would render the inner ear particularly vulnerable to noise. A two process model is envisaged: (a) initiation of reactive oxygen species by moderate noise exposure and (b) promotion of oxidative stress through disrupting intrinsic antioxidant defenses. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Fechter, L D AU - Pouyatos, B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Chemicals KW - Oxygen KW - Antioxidants KW - Stress KW - Hearing loss KW - Working conditions KW - Occupational exposure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19389010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fechter%2C+L+D%3BPouyatos%2C+B&rft.aulast=Fechter&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Predicting+Potentiation+of+Noise-Induced+Hearing+Loss+by+Chemicals%3A+Oxidative+Stress+as+a+Mechanism+of+Hearing+Loss&rft.title=Predicting+Potentiation+of+Noise-Induced+Hearing+Loss+by+Chemicals%3A+Oxidative+Stress+as+a+Mechanism+of+Hearing+Loss&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Noise Exposure and Hearing Conservation Programs in Eight Noisy Industries AN - 19388976; 7157388 AB - Occupational noise-induced hearing loss is generally a preventable condition. The Occupational Safety and Health Administration (OSHA) requires most employers with noisy workplaces to maintain effective hearing conservation programs and, when noise levels are relatively high, to use feasible noise controls. However, occupational hearing loss (OHL) remains a common disease. It is conceivable that current workers' risk for OHL may have been minimized by hearing conservation programs and noise controls implemented during twenty years of OSHA regulation, but noise exposures and regulatory compliance have not recently been broadly assessed. Therefore, we conducted a cross-sectional study of 76 companies in eight industries in one state, to characterize current noise exposures and hearing loss prevention practices. Industry selection was based on high rates of workers' compensation claims for OHL. Each company evaluation included personal noise dosimetry (n=983) and interviews (n=1,557) of selected workers, interviews of hearing conservation program coordinators (n=76), and reports and observations of hearing protector use. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Daniell, W E AU - Swan, S S AU - Camp, J AU - McDaniel, M M AU - Cohen, M AU - Stebbins, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - workers' compensation KW - Federal regulations KW - Compliance KW - Noise levels KW - prevention KW - safety regulations KW - Hearing loss KW - Occupational exposure KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Daniell%2C+W+E%3BSwan%2C+S+S%3BCamp%2C+J%3BMcDaniel%2C+M+M%3BCohen%2C+M%3BStebbins%2C+J&rft.aulast=Daniell&rft.aufirst=W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Noise+Exposure+and+Hearing+Conservation+Programs+in+Eight+Noisy+Industries&rft.title=Noise+Exposure+and+Hearing+Conservation+Programs+in+Eight+Noisy+Industries&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Violence Prevention in the Mental Health Setting: The New York State Experience AN - 19388962; 7157386 AB - In the mid 1990's, the New York State Office of Mental Health (OMH) collaborated with staff labor unions in pilot initiatives to reduce workplace violence. One product of these efforts was the 1998 issuance of an agency policy requiring all NY State operated psychiatric facilities to develop and implement a proactive violence prevention program modeled after the OSHA Guidelines for Violence Prevention for Health Care and Social Service Workers. This presented a unique opportunity to evaluate the impact of the Guidelines on worker health and safety. This presentation will provide a summary of a NIOSH supported intervention effectiveness study of violence prevention in the mental health in-patient setting. We will describe a process for implementing the Guidelines in three intervention facilities and findings from the evaluation of the impact of the intervention on risk factors for violence and physical assault in both intervention and comparison facilities following program implementation. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Lipscomb, JA AU - McPhaul, K AU - Rosen, J AU - Soeken, K AU - Choi, M AU - Vignola, V AU - Foley, J AU - Porter, P Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Federal regulations KW - Health care KW - Occupational safety KW - prevention KW - safety regulations KW - Violence KW - USA, New York KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Lipscomb%2C+JA%3BMcPhaul%2C+K%3BRosen%2C+J%3BSoeken%2C+K%3BChoi%2C+M%3BVignola%2C+V%3BFoley%2C+J%3BPorter%2C+P&rft.aulast=Lipscomb&rft.aufirst=JA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Violence+Prevention+in+the+Mental+Health+Setting%3A+The+New+York+State+Experience&rft.title=Violence+Prevention+in+the+Mental+Health+Setting%3A+The+New+York+State+Experience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Participative Ergonomics for Manual Tasks Injury Prevention in Australian Coal Mines AN - 19388939; 7157375 AB - A participative ergonomics approach to manual task injury prevention asserts that, given sufficient training and motivation, work teams are in the best position to undertake hazard identification, risk assessment and risk control activities. This paper describes a multiple case study in which a participative ergonomics for manual tasks program incorporating training in manual tasks risk assessment and control was implemented in 11 surface and underground coal mines. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Burgess-Limerick, R J AU - Straker, L AU - Pollock, C AU - Dennis, G AU - Leveritt, S AU - Johnson, S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Injuries KW - Training KW - prevention KW - Australia KW - Coal KW - Mines KW - working conditions KW - Ergonomics KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Burgess-Limerick%2C+R+J%3BStraker%2C+L%3BPollock%2C+C%3BDennis%2C+G%3BLeveritt%2C+S%3BJohnson%2C+S&rft.aulast=Burgess-Limerick&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Participative+Ergonomics+for+Manual+Tasks+Injury+Prevention+in+Australian+Coal+Mines&rft.title=Participative+Ergonomics+for+Manual+Tasks+Injury+Prevention+in+Australian+Coal+Mines&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Remotely Installed Mine Seals: A Technology Upgrade AN - 19388914; 7157374 AB - Over the last 6 years, 20 mine fires or thermal events have occurred in underground coal mines in the United States. On average about three events have occurred each year and a maximum of five events have occurred in any given year over this time period. Although not all mine fires cause fatalities, each event has the potential for disastrous consequences due to the presence of methane gas and the limited means of egress from the mine. Direct attempts are normally made underground to control the fire through the application of fire extinguishing material. However, an indirect approach is applied when access to the fire zone is impossible. This approach involves the construction of mine seals to close off mine openings to limit the inflow of oxygen and enclose the fire zone. Mine seals can be constructed from within the mine or remotely from vertical boreholes. The process is usually followed by flooding the affected area or the entire mine with water, inert gases, silt or other material to extinguish the fire. When underground access is impossible or too dangerous, mine seals are often constructed remotely from the surface through vertical boreholes. Underground observations suggest that the current available commercial technology often cannot fully close the mine opening. The resultant mine seals cannot adequately control inflow of oxygen which can lead to uncontrolled growth of a mine fire. Also, seals that do not close the mine opening cannot be used as bulkheads for impounding water or inert gases for fire extinguishment. Research is underway under a NIOSH-funded small NORA effort that was initiated in 2005. This work is designed to identify and remedy existing technology shortcomings, to develop novel technologies, and to transfer the new or improved technologies to the mining industry as soon as possible. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Trevits, MA AU - Smith, A C AU - Brune, J F Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Oxygen KW - Methane KW - Mortality KW - USA KW - Gases KW - Coal KW - Mines KW - Occupational exposure KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Trevits%2C+MA%3BSmith%2C+A+C%3BBrune%2C+J+F&rft.aulast=Trevits&rft.aufirst=MA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Remotely+Installed+Mine+Seals%3A+A+Technology+Upgrade&rft.title=Remotely+Installed+Mine+Seals%3A+A+Technology+Upgrade&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Person-Wearable Monitor to Continuously Measure Occupational Dust Concentrations AN - 19388900; 7157372 AB - Measurement of workplace dust is an essential first step in eliminating lung disease caused by overexposure to dust. Currently, personal coal mine dust exposure measurements rely on a filter-based method, which takes days or weeks before the results are returned to the miner. NIOSH in partnership with the National Mining Association, Bituminous Coal Operators Association, and the United Mine Workers of America has embarked on research to improve sampling instrumentation for use in the mining industry at the recommendation of The Secretary of Labor and the Federal Advisory Committee on the Elimination of Pneumoconiosis among Coal Mine Workers. As a result of this research, a new person-wearable monitor, to continuously assess occupational exposure to respirable particulate, has been developed through the miniaturization of a highly successful environmental monitor. Extensive field testing in coal mines has shown that this monitor accurately measures occupational coal dust concentrations and is comparable to the technique used for regulatory measurement. Applications to other areas of industrial hygiene monitoring are anticipated. Results of this research effort will be disseminated through Partnership meetings, publications, and workshops. Additionally, further research will be conducted to evaluate how miners make use of this technology in their day to day work environment. This will further the r2p process. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Mischler, SE Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Inhalation KW - Lung KW - Pneumoconiosis KW - Coal KW - Particulates KW - Mines KW - Dust KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mischler%2C+SE&rft.aulast=Mischler&rft.aufirst=SE&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Person-Wearable+Monitor+to+Continuously+Measure+Occupational+Dust+Concentrations&rft.title=A+Person-Wearable+Monitor+to+Continuously+Measure+Occupational+Dust+Concentrations&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Reliability of an Observational Tool to Assess Personal Computer Keyboarding Style AN - 19388881; 7157340 AB - Computer use has been identified as one probable cause of work-related musculoskeletal disorders of the upper extremity (MSD-UE). Currently more than half the of all workers use a computer at work (1), and the number has been growing steadily since 1993. The incidence of computer related MSD-UE is around 20% (2) suggesting that a significant number of computer-related MSD-UE disorders occur due to computer use. While computer use is a potential risk factor for MSD-UE, there are currently few methods available to evaluate computer keyboard use, and none of these instrument evaluates the user's hands and fingers. There is currently no observational assessment tool available that can be used to document the postures and actions of the neck, arm, hand, and fingers during computer keyboarding. The purpose of this study was to describe the reliability of an observational computer workstyle tool called the Evaluation of Personal Computer Keyboard Style (PeCKS), a 20 item rating scale that documents the frequency of stereotypical motions and posture combinations hypothesized to be potential risk factors for MSD-UE that are used by computer keyboarders during routine typing tasks. Items on the PeCKS can be divided into 3 general categories, (items of static posture, items of dynamic postures (frequencies), and items of force and tension), and examines postures and actions of the torso, neck, arms, wrist, hands and fingers. When completed this assessment tool will provide researchers and clinicians with a valid and reliable method to describe computer keyboarding postures and kinematics. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Baker, NA AU - Redfern, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - keyboarding KW - Health & Safety Science Abstracts KW - Man-machine interactions KW - Ergonomics KW - musculoskeletal system KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Baker%2C+NA%3BRedfern%2C+M&rft.aulast=Baker&rft.aufirst=NA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Reliability+of+an+Observational+Tool+to+Assess+Personal+Computer+Keyboarding+Style&rft.title=The+Reliability+of+an+Observational+Tool+to+Assess+Personal+Computer+Keyboarding+Style&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Selling Driver Safety in a Safety Naive Organisation AN - 19388878; 7157351 AB - Driver safety is a growing issue for governments and organisations. However the section of the organisation using drivers for business may be culturally safety naive even in organisations with an espoused safety culture. This abstract documents the empirical methodology utilised to identify mechanisms of managing safety that engage and motivate this group to improve their safety performance. The purpose of this study was to develop and instigate a standard approach that would reduce the number of serious accident in the company. The company has many thousands of sales people internationally. Despite training and senior management demands this group of drivers were responsible for more than 30% of all serious accidents. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Howell, R K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Accidents KW - Training KW - Motor vehicles KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Howell%2C+R+K&rft.aulast=Howell&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Selling+Driver+Safety+in+a+Safety+Naive+Organisation&rft.title=Selling+Driver+Safety+in+a+Safety+Naive+Organisation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Reliability Of Observational Posture Assessment Using Multimedia Video Task Analysis AN - 19388859; 7157338 AB - An important step in developing improved exposure assessment tools for MSDs is the evaluation of intra- and inter-rater reliability. Reliable exposure measurements are necessary to establish causal relationships between occupational risk factors and health outcomes. Unreliable exposure methods due to random error may over or underestimate the risk of health outcomes. The National Institute for Occupational Safety and Health (NIOSH, 1997) and the National Research Council (NRC/IOM, 2001) have both called for improved methods to assess risk factor exposure in occupational health studies. Due to the magnitude of musculoskeletal injuries and their associated costs, the NIOSH included "upper extremity MSDs" as one of the priority areas in its National Occupational Research Agenda (NIOSH, 2004). Improved exposure assessment methods were another priority identified in the National Occupational Research Agenda (NIOSH, 2004). There are few studies that have assessed the reliability of postural observation of specific body parts and postures across subjects, raters, and occasions. This study evaluated the inter- and intra-rater reliability of assessing worker posture during manufacturing tasks using Multimedia Video Task Analysis (MVTA), a relatively new exposure assessment tool. Posture of the neck, shoulder, and wrist of 20 manufacturing employees was evaluated by two raters from digital video footage of employees. Inter- and intra-rater reliability were estimated for all posture categories evaluated. Generalizability theory was used to estimate the inter- and intra-rater reliability. Inter-rater reliability results demonstrated good to excellent reliability for neck and shoulder postures and fair to excellent reliability for wrist postures. Intra-rater reliability results demonstrated good to excellent reliability for both raters evaluating all postures of the neck, shoulder, and wrist. This reliability study was part of a larger epidemiological prospective cohort study that investigated the relationship between hand-intensive work and upper extremity MSDs at a home appliance manufacturing facility in the Midwest. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Dartt, A AU - Rosecrance, J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - multimedia video KW - Health & Safety Science Abstracts KW - Manufacturing industry KW - Injuries KW - Occupational safety KW - musculoskeletal system KW - posture KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dartt%2C+A%3BRosecrance%2C+J&rft.aulast=Dartt&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Reliability+Of+Observational+Posture+Assessment+Using+Multimedia+Video+Task+Analysis&rft.title=Reliability+Of+Observational+Posture+Assessment+Using+Multimedia+Video+Task+Analysis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Conceptual Model for Minority Worker Experiences: Identifying Problems of Work Organization AN - 19388841; 7157330 AB - Racial and ethnic minorities have among the highest risk for exposure to adverse workplace conditions that lead to injury and illness. Language barriers, education level, social class, immigration status, scarce cultural resources, power imbalances, discrimination, and racism are factors creating this disparity. These factors also limit job availability, directing them to low paid, dangerous, and exploitive employment where worker safety and health are neglected. While the risk of occupational exposures for racial and ethnic minority workers is well recognized, the mechanisms by which work organization influences their vulnerability for injury and illness has not been adequately examined. A primary challenge is finding reliable access to these workers for datacollection. Collaboration with community-based organizations that advocate for vulnerable workers can be an effective approach to uncovering these workers' problems. The purpose of this study is to identify and conceptualize the way work organization affects well-being. It uses complaints reported to a metropolitan workers' rights center that serves primarily immigrant workers. We develop a model based on qualitative data that illustrates racial and ethnic minority workers' particular work experience. The model suggests critical pathways for potential interventions to addressing workers' needs. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Fujishiro, K AU - de Castro, B AU - Oliva, J L Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Education KW - discrimination KW - Injuries KW - immigrants KW - Occupational safety KW - Occupational exposure KW - Ethnic groups KW - Working conditions KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fujishiro%2C+K%3Bde+Castro%2C+B%3BOliva%2C+J+L&rft.aulast=Fujishiro&rft.aufirst=K&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Conceptual+Model+for+Minority+Worker+Experiences%3A+Identifying+Problems+of+Work+Organization&rft.title=A+Conceptual+Model+for+Minority+Worker+Experiences%3A+Identifying+Problems+of+Work+Organization&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Occupational Health Hazards of Orchestra Musicians AN - 19388824; 7157324 AB - The phrase "occupational health", invokes visions of steel workers with back injuries, computer operators with carpal tunnel syndrome, and construction workers with asbestiosis. Seldom does "occupational" health conjure up a picture of a violinist with hearing impairment, a trumpet player with a focal dystonia, or a musician with severe depression. With approximately 62 million individuals in the US earning their living playing a musical instrument, the occupational health concerns of this special population deserves evaluation and study. The very real challenges of this most highly competitive environment, the isolation and loneliness of solitary practice, the stresses of extensive travel, and performance anxiety have been well documented. The gap in the research literature relates to the occupational hazards of the orchestral musician. The purpose of this population study is to begin the compilation of the occupational hazards specific to full time work as a musician in an orchestra. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Romeo, J H Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - musicians KW - Health & Safety Science Abstracts KW - Travel KW - Vision KW - carpal tunnel syndrome KW - overuse injuries KW - Stress KW - depression KW - Construction industry KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Romeo%2C+J+H&rft.aulast=Romeo&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Health+Hazards+of+Orchestra+Musicians&rft.title=Occupational+Health+Hazards+of+Orchestra+Musicians&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - An Innovative Approach to Occupational Injury Surveillance in the Developing World AN - 19388811; 7157312 AB - Vietnam's rapid transition to a market economy while stimulating strong economic growth has been offset with a dramatic increase in injury. An active surveillance study has been initiated in one community of Vietnam to pilot methods for comprehensive capture of occupational injuries in Vietnam. The data collected includes both formal and informal sectors. The Xuan Tien commune, Nam Dinh Province was chosen as an appropriate community for tracking the incidence of injuries because: 1) Xuan Tien with approximately 2,400 households and 10,500 individuals is a feasible size for 100% sample; 2) Xuan Tien has a stable but developing industrial base with some medium and large enterprises and many family owned businesses. Many rural communes in Vietnam are expected to develop similarly; 3) All formal health care for residents of Xuan Tien is delivered through one hospital and one commune health station; and 4) The district hospital and commune health station doctors have a very good working relationship with the provincial medical center in Nam Dinh and have a personal interest in injury themselves. Reporting logs of all injuries occurring in the Xuan Tien commune over a one-year period are being collected bi-weekly from all active formal and informal treatment options including: the district hospital, commune health station, pharmacies, and healers. In addition to this 10 health volunteers already working in their villages to administer vaccines and aids prevention activities have been trained to report injuries in a log book. Finally, first aid boxes have been placed in all medium, large and a sample of small enterprises, innovatively collecting reports of injuries because treatment requires entry onto a reporting form. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Marucci-Wellman, H AU - Binh, TTT AU - Diep, N B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - vaccines KW - Injuries KW - Occupational safety KW - Medical personnel KW - Vietnam KW - Health care KW - Books KW - Economics KW - prevention KW - Developing countries KW - Hospitals KW - Rural areas KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Marucci-Wellman%2C+H%3BBinh%2C+TTT%3BDiep%2C+N+B&rft.aulast=Marucci-Wellman&rft.aufirst=H&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=An+Innovative+Approach+to+Occupational+Injury+Surveillance+in+the+Developing+World&rft.title=An+Innovative+Approach+to+Occupational+Injury+Surveillance+in+the+Developing+World&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Innovative Health Care Worker Training: Infectious Disease Risk AN - 19388798; 7157294 AB - Health care workers, including nurses, are at risk for a wide range of occupational health hazards, including the risk from infectious diseases such as bloodborne pathogens and tuberculosis, To reduce morbidity and mortality associated with occupationally acquired infections, a number of risk management strategies have been developed. Although safety training programs are acknowledged as an important part of an overall risk management strategy, there are a number of challenges to effective health and safety training, especially in the health care work setting. To address this problem, a multidisciplinary team of researchers partnered with two large medical centers and a professional nurses' association to evaluate an innovative approach to safety training for nurses. Simulation exercises,shown to be an effective safety training method in other occupational settings, were developed using a participatory action research format. The exercises, which target bloodborne pathogens, were formatted into a computerized, interactive, Web-based program and administered to 130 volunteer registered nurses who were recruited with assistance from our partner collaborators. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gershon, R G AU - Cole, H Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - Mycobacterium KW - Training KW - Simulation KW - Pathogens KW - Infection KW - Medical personnel KW - Morbidity KW - Physical training KW - tuberculosis KW - infectious diseases KW - Health care KW - Infectious diseases KW - Tuberculosis KW - nursing KW - Occupational health KW - R2 23080:Industrial and labor KW - J 02400:Human Diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gershon%2C+R+G%3BCole%2C+H&rft.aulast=Gershon&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Innovative+Health+Care+Worker+Training%3A+Infectious+Disease+Risk&rft.title=Innovative+Health+Care+Worker+Training%3A+Infectious+Disease+Risk&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - A Safety Information Campaign to Reduce Sharps Injuries: Preliminary Results from the "Stop Sticks Campaign" AN - 19388793; 7157291 AB - CDC estimates that more than 350,000 contaminated needlesticks occur every year among hospital workers in the U.S. As many as half of those injuries are not reported to the employer. The risk of acquiring a bloodborne pathogen infection from needlestick injuries varies according to a number of factors and the type of pathogen. Nevertheless, every injury may cost both the employee and the employer time and money for employee testing, post-exposure prophylaxis, and stress from the fact that illnesses resulting from such infections are serious and sometimes life-threatening. Needlestick injuries occur with many occupational groups in hospitals. Although most occur among clinical-care workers, non-clinical workers such as housekeepers, maintenance workers, and laundry workers may also be injured. Sharps devices with safety features are a major component of most needlestick prevention programs. Frontline workers with patient care responsibilities must be involved in the trial and selection of the most appropriate devices for each procedure in each facility. However, comprehensive exposure control plans, adequately-sized and placed sharps disposal containers, improved work practices, diligent injury reporting, and post-exposure follow-up are important parts of the prevention effort. Training and information activities are critical for maintaining prevention awareness and skills among all health care workers. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Sinclair, R C AU - Harney, A G AU - Smallwood, S W AU - Christianson, AL Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Containers KW - Injuries KW - Training KW - Stress KW - needles KW - Pathogens KW - Medical personnel KW - USA KW - Health care KW - prevention KW - infection KW - Occupational exposure KW - Hospitals KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sinclair%2C+R+C%3BHarney%2C+A+G%3BSmallwood%2C+S+W%3BChristianson%2C+AL&rft.aulast=Sinclair&rft.aufirst=R&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Safety+Information+Campaign+to+Reduce+Sharps+Injuries%3A+Preliminary+Results+from+the+%22Stop+Sticks+Campaign%22&rft.title=A+Safety+Information+Campaign+to+Reduce+Sharps+Injuries%3A+Preliminary+Results+from+the+%22Stop+Sticks+Campaign%22&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Effectiveness of Farm Safety Day Camps: Influence of Camp Characteristics AN - 19388776; 7157260 AB - Importance: Farming is unique among work settings in level of risk for children and youth. Exposures to agricultural hazards occur through play, work, and observation of adult work. In response to these risks, communities offer a variety of educational programs, including farm safety day camps conducted for prevention of childhood agricultural injury. Hundreds of farm safety day camps are attended each year by thousands of children in rural communities across North America. Although significant financial and human resources are devoted to these camps, the impact and effectiveness of the programs have not been systematically demonstrated, Additional research is needed to evaluate the camps as a method for teaching safe behaviors to children exposed to agricultural hazards. Purpose: Data presented here are part of a larger evaluation of a North American farm safety day camp program. Changes in knowledge and self-reported behaviors of camp participants were assessed to determine the impact of the camps. In addition, various camp characteristics, such as size and type of camp and number and length of teaching sessions, were investigated to determine their relative effectiveness. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - McCallum, D M AU - Reynolds, S J AU - Conaway, M B Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - North America KW - Education KW - Farms KW - Injuries KW - Occupational safety KW - prevention KW - Children KW - Rural areas KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McCallum%2C+D+M%3BReynolds%2C+S+J%3BConaway%2C+M+B&rft.aulast=McCallum&rft.aufirst=D&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Effectiveness+of+Farm+Safety+Day+Camps%3A+Influence+of+Camp+Characteristics&rft.title=Effectiveness+of+Farm+Safety+Day+Camps%3A+Influence+of+Camp+Characteristics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Musculoskeletal Injuries and Disorders Among a Large Cohort of Health Care Workers: Analyses from the Duke Health and Safety Surveillance System (DHSSS) AN - 19388764; 7157289 AB - Health care workers are at risk for musculoskeletal (MSK) injuries and disorders due to a variety of physically demanding tasks that they perform. Because these conditions often lack a discrete onset they may be more difficult to capture using standard surveillance methods. To more comprehensively evaluate the burden of these conditions among a large cohort of workers employed at a tertiary care medical center, we are using data that combines workers' compensation (WC) records, private outpatient health care claims, and human resources data. Between 1997 and 2003, 21,393 employees reported a total of 3103 musculoskeletal injuries through the WC system. Claims were more likely to be filed by female workers (77%), and those between the ages of 30 to 49 (64%). Claims filed by African-American employees were disproportionate to their representation in the workforce; 46% of claims were filed by these workers who represent 26% of the workforce. Back (43%), shoulder (11%) and knee (8%) injuries were the body sites most frequently reported to be injured. Patient handling tasks were responsible for 46% and 34% of back and shoulder injuries, respectively, while falls (mostly from slips and trips) accounted for a little more than half (52%) of all knee injuries. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Pompeii, LA AU - Lipscomb, HJ AU - Dement, J M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - workers' compensation KW - Injuries KW - Health care KW - Ethnic groups KW - Medical personnel KW - musculoskeletal system KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Pompeii%2C+LA%3BLipscomb%2C+HJ%3BDement%2C+J+M&rft.aulast=Pompeii&rft.aufirst=LA&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Musculoskeletal+Injuries+and+Disorders+Among+a+Large+Cohort+of+Health+Care+Workers%3A+Analyses+from+the+Duke+Health+and+Safety+Surveillance+System+%28DHSSS%29&rft.title=Musculoskeletal+Injuries+and+Disorders+Among+a+Large+Cohort+of+Health+Care+Workers%3A+Analyses+from+the+Duke+Health+and+Safety+Surveillance+System+%28DHSSS%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - NIOSH-Designed Adjustable Roof Bracket and Safety Rail Assembly AN - 19388738; 7157276 AB - Importance of problem: Fall-related fatalities and serious injuries are still prevalent in the U.S. construction industry. The primary cause is roof-related and includes falls from roof edges, or through roof holes and skylight fixtures. Bureau of Labor Statistics data indicate that for 1992-2000, an average of 208,000 roofers were employed each year. Other construction trades also work at elevations and all are exposed to situations where they could fall, resulting in a fatality or a serious injury involving days away from work (DAFW). For 1998-2003, BLS data reveal that a yearly average of 147 workers were killed and 3,657 workers were seriously injured after falling from roof edges or through roof holes and skylights. Roof-related fall injuries are among the most severe cases, as measured by median DAFW. Compared to all types of fall-to-lower-level cases in U.S. private industry, falls from roofs and falls through roof holes and skylights were two to four times more severe than all other fall-to-lower-level cases. Objective of study: The objective was to develop a highly adjustable, securely fastened, durable worker-support bracket and safety rail assembly to provide a guardrail system to protect workers from sliding off roof edges, or falling through unprotected roof/floor holes, stairwells, balconies, and existing skylights. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Bobick, T G AU - Cantis, D M AU - McKenzie, E Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Prevention KW - Injuries KW - Falls KW - Occupational safety KW - Protective equipment KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bobick%2C+T+G%3BCantis%2C+D+M%3BMcKenzie%2C+E&rft.aulast=Bobick&rft.aufirst=T&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NIOSH-Designed+Adjustable+Roof+Bracket+and+Safety+Rail+Assembly&rft.title=NIOSH-Designed+Adjustable+Roof+Bracket+and+Safety+Rail+Assembly&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Ladder Fall Prevention Initiative for Construction Industry AN - 19388711; 7157275 AB - Introduction/Broad objectives: Ladder safety in the construction industry is an important public health issue in need of attention. Fatalities and injuries from ladder falls have been on the rise across the U.S. in recent years. According to the Bureau of Labor Statistics' 2004 Census of Fatal Occupational Injuries there was a 17% increase between 2003 and 2004, with 114 fatal ladder falls reported in 2004. Since ladder falls are entirely preventable, proper training on ladder safety techniques is essential to address this public health issue with the ultimate goal of prevention. Purpose: The objectives of this collaborative initiative are to develop a ladder fall prevention film and several fact sheets to be administered to construction workers, and to evaluate the impact of these tools. Pilot testing of the film was conducted during its development to evaluate the tool's effectiveness and identify areas in need of improvement. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gittleman, J AU - Nagrod, J AU - McGreevy, K Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - ladders KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Falls KW - Injuries KW - Training KW - Occupational safety KW - prevention KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gittleman%2C+J%3BNagrod%2C+J%3BMcGreevy%2C+K&rft.aulast=Gittleman&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Ladder+Fall+Prevention+Initiative+for+Construction+Industry&rft.title=Ladder+Fall+Prevention+Initiative+for+Construction+Industry&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Unique Occupational Injury Surveillance: Identification of the Total Injury Burden and Risks on Agricultural Operations AN - 19388680; 7157253 AB - Agriculture has consistently been identified as one of the most hazardous occupations in the United States (U.S.); rates of morbidity and mortality greatly exceed those for all occupations combined. Currently, no systems exist that can provide accurate data on the incidence and severity of, and risk factors for agriculture-related injury, or how they change over time -- information integral to the u ltimate control of this problem. The purpose of this effort was to utilize a unique model for conducting surveillance among agricultural operation households that enabled monitoring for changes, between 1999 and 2001, in the incidence and consequences of both agricultural activity-related injuries and those incurred from other activities, by all ages. It also enabled identification of risk factors for agricultural activity-related injuries incurred by children less than 20 (<20) years of age, by comparing exposures between injured and uninjured children. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Gerberich, S G AU - Church, T R AU - Alexander, B H AU - Masten, A S AU - Renier, C M AU - Carlson, K F AU - Ryan, AD AU - Mongin, S J Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - Mortality KW - USA KW - Injuries KW - Occupational safety KW - Children KW - Morbidity KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Gerberich%2C+S+G%3BChurch%2C+T+R%3BAlexander%2C+B+H%3BMasten%2C+A+S%3BRenier%2C+C+M%3BCarlson%2C+K+F%3BRyan%2C+AD%3BMongin%2C+S+J&rft.aulast=Gerberich&rft.aufirst=S&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Unique+Occupational+Injury+Surveillance%3A+Identification+of+the+Total+Injury+Burden+and+Risks+on+Agricultural+Operations&rft.title=Unique+Occupational+Injury+Surveillance%3A+Identification+of+the+Total+Injury+Burden+and+Risks+on+Agricultural+Operations&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - The Use of Recreational Techniques to Raise Awareness and Train Workers in Occupational Risks Prevention AN - 19383143; 7157353 AB - OSH specialists in Latin America are concerned about the difficulties of installing an effective workplace prevention culture. Cultural change has proven elusive at all levels and risk identification and prevention is yet to be incorporated in managerial practices. Unless a change is achieved in the culture and practices of all actors involved in the production process, OSH specialists will hardly succeed in promoting a safer, healthier and more productive work environment. Awareness raising and training activities have become common denominators in OSH specialists' initiatives, advertisement of insurance companies, union claims, and legal framework issued by regulatory bodies. Nevertheless, one might wonder what results have been achieved and what obstacles are yet to be overcome. As of the passing of Work-Related Risks legislation, employers, insurance companies, unions and the State became responsible for improving workers' awareness and training in order to achieve better working conditions. However, their efforts have had a limited impact so far. Training contents tend to refer only to mandatory issues. There is also a language barrier: specific technical contents and advises are not translated into everyday language, making them hard to understand by specific audiences (manual and agricultural workers, for instance). Also, employers have shown little commitment to engage in awareness raising campaigns. Some institutions have developed remarkable initiatives, but even these success stories have fallen short in educational aspects. The root of this common limitation can be traced back to the superior educational system: OSH specialists lack specific training in communication, education and motivation in order to allow them to effectively convey knowledge and information that can be put into practice. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Margulis, L AU - Erbojo, E Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Risk Abstracts KW - Agriculture KW - Culture KW - Training KW - Latin America KW - Occupational safety KW - Risk reduction KW - Insurance KW - working conditions KW - Education KW - Communications KW - prevention KW - Legislation KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19383143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Margulis%2C+L%3BErbojo%2C+E&rft.aulast=Margulis&rft.aufirst=L&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Use+of+Recreational+Techniques+to+Raise+Awareness+and+Train+Workers+in+Occupational+Risks+Prevention&rft.title=The+Use+of+Recreational+Techniques+to+Raise+Awareness+and+Train+Workers+in+Occupational+Risks+Prevention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Linking Health and Productivity in Seated Environments: Results of an Intervention AN - 19383122; 7157339 AB - Musculoskeletal disorders remain a costly problem for businesses and place a great burden on the social insurance system. More and more Americans are playing and working in front of computers, yet the evidence base for making decisions on what are good or bad support technologies remains sparse. Is one keyboard better than another? How about a mouse or a trackball? What about ergonomics training? What about rest breaks while computing? Any literature review reveals few if any studies to draw conclusions for practice. Furthermore, few studies consider the productivity consequences of the intervention and provide little evidence of a return on investment. Simply put knowledge transfer from research to practice is inhibited by the research. The objective of this study was to evaluate the health and productivity consequences of a highly adjustable chair and an office ergonomics training program. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Amick, B C AU - Bazzani, L AU - Harrist, R AU - DeRango, K AU - Robertson, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Training KW - Reviews KW - Insurance KW - Ergonomics KW - working conditions KW - musculoskeletal system KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19383122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Amick%2C+B+C%3BBazzani%2C+L%3BHarrist%2C+R%3BDeRango%2C+K%3BRobertson%2C+M&rft.aulast=Amick&rft.aufirst=B&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Linking+Health+and+Productivity+in+Seated+Environments%3A+Results+of+an+Intervention&rft.title=Linking+Health+and+Productivity+in+Seated+Environments%3A+Results+of+an+Intervention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Using a Programmed Intervention of Intermittent Stretching to Decrease Musculoskeletal Discomfort Associated with Work at a Computer Workstation AN - 19383099; 7157322 AB - Importance: The National Occupational Research Agenda has identified musculoskeletal disorders of the upper extremities with associated prevention strategies and intervention effectiveness as priority areas. The effect of poor computer workstation design and the associated musculosketal discomfort (MSD) is often found to be of concern to those who utilize this technology and unless specific programs are put into place, ergonomic modifications to workstations are not used as intended. In 1997 the cost to the U.S. economy for painful conditions while at work was estimated to be $20 billion per year, by 2003 the cost estimate had increased to over $60 billion per year. The Bureau of Labor Statistics reported in 1998 that twelve percent of injured workers attributed their injuries to typing. Purpose: The goal of this study was to evaluate the effects of an intervention of regular stretching while seated at a computer workstation and to ascertain whether such a programcould bring about a significant reduction in MSD. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Marangoni, AH Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - Injuries KW - Economics KW - prevention KW - musculoskeletal system KW - Ergonomics KW - working conditions KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19383099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Marangoni%2C+AH&rft.aulast=Marangoni&rft.aufirst=AH&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Using+a+Programmed+Intervention+of+Intermittent+Stretching+to+Decrease+Musculoskeletal+Discomfort+Associated+with+Work+at+a+Computer+Workstation&rft.title=Using+a+Programmed+Intervention+of+Intermittent+Stretching+to+Decrease+Musculoskeletal+Discomfort+Associated+with+Work+at+a+Computer+Workstation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Issues of Chemical Exposure in Korean-American Drycleaners: Findings of Focus Group AN - 19383081; 7157318 AB - Background: Numerous health and safety risks in the dry cleaning industry have been identified by many researchers. Major health and safety issues identified include exposure to chemicals, mainly to exposure to perchloroethylene (PERC), personal protective equipment (PPE), ergonomics, and burns. The most significant hazards for workers in dry cleaning shops are exposure to PERC, a primary solvent used for dry cleaning. PERC has been identified as a harmful agent that develops health problems in various parts of the human body such as the central nervous system, respiratory system, liver, kidneys, and skin. The harmful effects of chemical exposure can be avoided by installing effective ventilation and using new safer dry cleaning equipment as well as by adequate work practice and use of personal protective equipment (PPE) by individuals. Korean-Americans own almost 50% of all dry cleaning shops and are a major workforce in the dry cleaning industry in the United States (Federal Korean Drycleaners Association, 2005; EPA, 1995). However, there is no research investigating Korean-American drycleaners' knowledge and concerns regarding health and safety issues related to their work. The purpose of this study was to obtain qualitative data on Korean-American dry cleaners' concerns about work-related health and safety and their attitudes toward the use of PPE through focus group interviews. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Jeong, A S AU - Hong, O S Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Central nervous system KW - Skin KW - Solvents KW - Protective equipment KW - working conditions KW - Perchloroethylene KW - EPA KW - USA KW - Kidney KW - Liver KW - Occupational exposure KW - Ergonomics KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19383081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Jeong%2C+A+S%3BHong%2C+O+S&rft.aulast=Jeong&rft.aufirst=A&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Issues+of+Chemical+Exposure+in+Korean-American+Drycleaners%3A+Findings+of+Focus+Group&rft.title=Issues+of+Chemical+Exposure+in+Korean-American+Drycleaners%3A+Findings+of+Focus+Group&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Improved Prediction of Dermal Absorption of Small Doses of Potentially Volatile Chemicals AN - 19383055; 7157308 AB - Dermal exposures span the range of NORA sectors, second in impact only to inhalation as a source of chemical hazard to workers. Dermal risk assessment concerns itself with identifying and quantifying the hazard associated with dermal exposure, starting with absorption of chemicals though the skin. Despite the considerable body of research in this area, accurate estimation of skin absorption subsequent to transient exposures to solvents, pesticides and other organic chemicals remains elusive. In this research project we have developed an improved tool for making such estimations. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kasting, G B AU - Miller, MA Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Risk assessment KW - Inhalation KW - Skin KW - Pesticides KW - Absorption KW - Solvents KW - Occupational exposure KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19383055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kasting%2C+G+B%3BMiller%2C+MA&rft.aulast=Kasting&rft.aufirst=G&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Improved+Prediction+of+Dermal+Absorption+of+Small+Doses+of+Potentially+Volatile+Chemicals&rft.title=Improved+Prediction+of+Dermal+Absorption+of+Small+Doses+of+Potentially+Volatile+Chemicals&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - BOOK T1 - Dump Truck-Related Deaths in Construction, 1992-2002 AN - 19382977; 7157277 AB - Dump trucks are used extensively in construction and other industries to remove debris from construction sites and to deliver materials. They are a continual presence on construction sites during the early stages of construction and can make many trips during the days from the site to a dumping place. The purpose of this study was to examine the causes of dump truck-related fatalities in construction in order to develop interventions to make it safer to work on or around dump trucks. Dump truck-related deaths were identified by selecting all records from 1992-2002 with source or secondary codes of "dump truck" (8252) from the Bureau of Labor Statistics database, the Census of Fatal Occupational Injuries. The records were analyzed for causes of death, worker activity and occupation. JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - McCann, M AU - Cheng, M Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Occupational safety KW - Trucks KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19382977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McCann%2C+M%3BCheng%2C+M&rft.aulast=McCann&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Dump+Truck-Related+Deaths+in+Construction%2C+1992-2002&rft.title=Dump+Truck-Related+Deaths+in+Construction%2C+1992-2002&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER - TY - JOUR T1 - Design, Construction, and Characterization of a Novel Robotic Welding Fume Generator and Inhalation Exposure System for Laboratory Animals AN - 17172571; 6832417 AB - Respiratory effects observed in welders have included lung function changes, metal fume fever, bronchitis, and a possible increase in the incidence of lung cancer. Many questions remain unanswered regarding the causality and possible underlying mechanisms associated with the potential toxic effects of welding fume inhalation. The objective of the present study was to construct a completely automated, computer-controlled welding fume generation and inhalation exposure system to simulate real workplace exposures. The system comprised a programmable six-axis robotic welding arm, a water-cooled arc welding torch, and a wire feeder that supplied the wire to the torch at a programmed rate. For the initial studies, gas metal arc welding was performed using a stainless steel electrode. A flexible trunk was attached to the robotic arm of the welder and was used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Undiluted fume concentrations consistently ranged from 90-150 mg/m super(3) in the animal chamber during welding. Temperature and humidity remained constant in the chamber during the welding operation. The welding particles were composed of (from highest to lowest concentration) iron, chromium, manganese, and nickel as measured by inductively coupled plasma atomic emission spectroscopy. Size distribution analysis indicated the mass median aerodynamic diameter of the generated particles to be approximately 0.24 mu m with a geometric standard deviation ( sigma sub(g)) of 1.39. As determined by transmission and scanning electron microscopy, the generated aerosols were mostly arranged as chain-like agglomerates of primary particles. Characterization of the laboratory-generated welding aerosol has indicated that particle morphology, size, and chemical composition are comparable to stainless steel welding fume generated in other studies. With the development of this novel system, it will be possible to establish an animal model using controlled welding exposures from automated gas metal arc and flux-cored arc welding processes to investigate how welding fumes affect health. JF - Journal of Occupational and Environmental Hygiene AU - Antonini, J M AU - Afshari, A A AU - Stone, S AU - Chen, Bean AU - Schwegler-Berry, D AU - Fletcher, W G AU - Goldsmith, W T AU - Vandestouwe, KH AU - McKinney, W AU - Castranova, V AU - Frazer, D G AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505, USA, jga6@cdc.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 194 EP - 203 VL - 3 IS - 4 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Inhalation KW - Metals KW - Aerosols KW - Fumes KW - Laboratory testing KW - Chromium KW - Temperature KW - Welding KW - Particulates KW - Occupational exposure KW - Robots KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17172571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Design%2C+Construction%2C+and+Characterization+of+a+Novel+Robotic+Welding+Fume+Generator+and+Inhalation+Exposure+System+for+Laboratory+Animals&rft.au=Antonini%2C+J+M%3BAfshari%2C+A+A%3BStone%2C+S%3BChen%2C+Bean%3BSchwegler-Berry%2C+D%3BFletcher%2C+W+G%3BGoldsmith%2C+W+T%3BVandestouwe%2C+KH%3BMcKinney%2C+W%3BCastranova%2C+V%3BFrazer%2C+D+G&rft.aulast=Antonini&rft.aufirst=J&rft.date=2006-04-01&rft.volume=3&rft.issue=4&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620600584352 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Metals; Aerosols; Fumes; Chromium; Laboratory testing; Temperature; Welding; Particulates; Occupational exposure; Robots DO - http://dx.doi.org/10.1080/15459620600584352 ER - TY - JOUR T1 - Recent Tanning Bed Use: A Risk Factor for Melanoma AN - 17147222; 6809060 AB - BACKGROUND: Individuals at increased risk of melanoma should use sun-protective measures to decrease their risk of developing melanoma. OBSERVATION: We report a case of a 39-year-old patient with a CDKN2A mutation who developed 3 primary melanomas within a few years of initiating tanning bed use. CONCLUSION: Intense UV exposure as an adult likely contributed to the development of additional primary melanomas in this individual. JF - Archives of Dermatology AU - Buckel, Tamy BH AU - Goldstein, Alisa M AU - Fraser, Mary C AU - Rogers, Barbara AU - Tucker, Margaret A AD - Division of Cancer Prevention and Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 485 EP - 488 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 142 IS - 4 SN - 0003-987X, 0003-987X KW - tanning beds KW - Health & Safety Science Abstracts; Risk Abstracts KW - Consumer products KW - Ultraviolet radiation KW - Cancer KW - R2 23020:Technological risks KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Dermatology&rft.atitle=Recent+Tanning+Bed+Use%3A+A+Risk+Factor+for+Melanoma&rft.au=Buckel%2C+Tamy+BH%3BGoldstein%2C+Alisa+M%3BFraser%2C+Mary+C%3BRogers%2C+Barbara%3BTucker%2C+Margaret+A&rft.aulast=Buckel&rft.aufirst=Tamy&rft.date=2006-04-01&rft.volume=142&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Archives+of+Dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Consumer products; Ultraviolet radiation; Cancer ER - TY - JOUR T1 - Effect of a National Vaccine Shortage on Vaccine Coverage for American Indian/Alaska Native Children AN - 17125682; 6750235 AB - OBJECTIVES: We determined the effect of national vaccine shortages on coverage with 4 doses of diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine for American Indian/Alaska Native (AIAN) children. METHODS: Data on DTaP coverage for children aged 19 to 27 months were abstracted from Indian Health Service (IHS) immunization reports. Coverage with the fourth DTaP dose (DTaP4) was compared for different periods to determine coverage levels before, during, and after the shortage. Data were stratified geographically to determine regional variation. RESULTS: AIAN children experienced a significant decline (14.8%) in DTaP4 coverage during the shortage. Considerable variation was seen among IHS regions (declines ranged from 4.5% to 26.5%). CONCLUSIONS: AIAN children included in IHS immunization reports experienced a greater decline in DTaP4 coverage during the shortage than the decline reported nationally for children receiving vaccine at public clinics (14.8% vs 6%). Variations in the decline in coverage highlight possible inequities in vaccine supply and distribution and in implementation of vaccine shortage recommendations. We must identify ways to ensure more equitable vaccine distribution and consistent implementation of vaccine recommendations to protect all children from vaccine-preventable diseases. JF - American Journal of Public Health AU - Groom, Amy V AU - Cheek, James E AU - Bryan, Ralph T AD - Amy V. Groom is with the Program Operations Branch, Immunization Services Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga, and is field assigned to the Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service, Albuquerque, NM. James E. Cheek is with the Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service. Ralph T. Bryan is with the Office of Minority Health and Health Disparities, Office of Strategy and Innovation, Office of the Director, Centers for Disease Control and Prevention, and is field assigned to the Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 697 EP - 701 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 4 SN - 0090-0036, 0090-0036 KW - Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Vaccines KW - Toxoids KW - Diphtheria KW - Children KW - Tetanus KW - Immunization KW - Public health KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17125682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Effect+of+a+National+Vaccine+Shortage+on+Vaccine+Coverage+for+American+Indian%2FAlaska+Native+Children&rft.au=Groom%2C+Amy+V%3BCheek%2C+James+E%3BBryan%2C+Ralph+T&rft.aulast=Groom&rft.aufirst=Amy&rft.date=2006-04-01&rft.volume=96&rft.issue=4&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Pertussis; Diphtheria; Toxoids; Vaccines; Tetanus; Children; Immunization; Public health ER - TY - JOUR T1 - Public Health Strategies to Overcome Barriers to Optimal Vitamin D Status in Populations with Special Needs AN - 17123524; 6748994 AB - In North America, there is increasing public health awareness of the importance of adequate vitamin D intake to the maintenance of optimal vitamin D status and overall health. Experts now define this as circulating levels of 25-hydroxyvitamin D of 75-80 nmol/L. This serum level and high levels of dietary intake have been associated with significantly reduced risk of chronic diseases, such as osteoporosis, cardiovascular disease, diabetes, and some cancers. All of these diseases are more prevalent in the elderly of all races, and some are more prevalent and of greater severity among blacks than whites. Our objective is to review recent actions to increase public awareness of the health importance of maintaining optimal circulating 25(OH)D and potential strategies to increase vitamin D intake. Clinicians and educators are encouraged to promote improved vitamin D intake and status, particularly among the elderly and blacks. This will largely depend on combined efforts to judiciously fortify our food supply and to develop individual supplementation protocols for supplements or controlled use of UV light exposure to maintain optimal serum 25(OH)D, especially in high-risk groups. Growing evidence supports a low risk of toxicity with vitamin D use in fortification or supplementation, despite its past reputation of potential toxicity in excess. The cost to fortify food or supplements with vitamin D is relatively inexpensive compared with developing drugs used to treat or prevent chronic diseases; moreover, there is significant potential for broad health benefits in the reduced risk and prevention of multiple chronic diseases. JF - Journal of Nutrition AU - Calvo, Mona S AU - Whiting, Susan J AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD and College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1135 EP - 1139 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 4 SN - 0022-3166, 0022-3166 KW - vitamin D KW - Risk Abstracts KW - North America KW - Reviews KW - prevention KW - Toxicity KW - Cardiovascular diseases KW - elderly KW - Nutrition KW - Public health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17123524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Public+Health+Strategies+to+Overcome+Barriers+to+Optimal+Vitamin+D+Status+in+Populations+with+Special+Needs&rft.au=Calvo%2C+Mona+S%3BWhiting%2C+Susan+J&rft.aulast=Calvo&rft.aufirst=Mona&rft.date=2006-04-01&rft.volume=136&rft.issue=4&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Reviews; prevention; Cardiovascular diseases; Toxicity; elderly; Nutrition; Public health; North America ER - TY - JOUR T1 - CpG Oligodeoxynucleotides Protect Newborn Mice from a Lethal Challenge with the Neurotropic Tacaribe Arenavirus AN - 17122492; 6748803 AB - The innate immune system is key to limiting the early spread of most pathogens and directing the development of Ag-specific immunity. Recently, a number of synthetic molecules that activate the innate immune system by stimulating TLRs have been identified. Among them, synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs (CpG ODNs) were shown to activate TLR9-bearing B cells, macrophages, and dendritic cells to induce a strong proinflammatory milieu and a type 1-biased immune response that protects mice from a variety of parasitic, bacterial, and viral infections. Although the protective effect of CpG ODN in adult mice was well established, its effectiveness in neonates, which have lower numbers of dendritic, B, and T cells and tend to favor Th2 responses, was unclear. This study uses the New World arenavirus Tacaribe, a neurotropic pathogen that is lethal in newborn mice, to explore the effectiveness of TLR-mediated innate immune responses. Neonatal BALB/c mice treated with CpG ODN at the time of infection had reduced viral load (p < 0.01) and increased survival (52%, p < 0.001 i.p.; 36%, p < 0.05 intranasally). Protection was achieved in mice treated no later than 3 days postchallenge and appears to be mediated by an increase in Ag-specific Abs (IgG and IgM) and to require inducible NO synthase expression and NO production. To our knowledge, this is the first study assessing the mechanisms by which CpG ODN can protect mice from a neurotropic viral infection. JF - Journal of Immunology AU - Pedras-Vasconcelos, Joao A AU - Goucher, David AU - Puig, Montserrat AU - Tonelli, Leonardo H AU - Wang, Vivian AU - Ito, Shuichi AU - Verthelyi, Daniela AD - Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Federal Drug Administration, Bethesda, MD 20892. Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892. Division of Viral Products, Center for Biologics Evaluation and Research, Federal Drug Administration, Rockville, MD 20852 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4940 EP - 4949 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 8 SN - 0022-1767, 0022-1767 KW - mice KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Macrophages KW - Lymphocytes B KW - Immune system KW - Helper cells KW - Survival KW - Pathogens KW - CpG islands KW - Infection KW - Oligonucleotides KW - Arenavirus KW - Inflammation KW - Nitric-oxide synthase KW - Dendritic cells KW - Lymphocytes T KW - Immunoglobulin G KW - Nitric oxide KW - Neonates KW - Immunoglobulin M KW - V 22099:Immune response & immune mechanisms KW - J 02350:Immunology KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17122492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CpG+Oligodeoxynucleotides+Protect+Newborn+Mice+from+a+Lethal+Challenge+with+the+Neurotropic+Tacaribe+Arenavirus&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BGoucher%2C+David%3BPuig%2C+Montserrat%3BTonelli%2C+Leonardo+H%3BWang%2C+Vivian%3BIto%2C+Shuichi%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2006-04-01&rft.volume=176&rft.issue=8&rft.spage=4940&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Lymphocytes B; Helper cells; Immune system; Survival; CpG islands; Pathogens; Infection; Oligonucleotides; Inflammation; Nitric-oxide synthase; Dendritic cells; Immunoglobulin G; Lymphocytes T; Nitric oxide; Neonates; Immunoglobulin M; Arenavirus ER - TY - JOUR T1 - Produce Isolates of the Escherichia coli Ont:H52 Serotype That Carry both Shiga Toxin 1 and Stable Toxin Genes AN - 17121798; 6750794 AB - Produce isolates of the Escherichia coli Ont:H52 serotype carried Shiga toxin 1 and stable toxin genes but only expressed Stx1. These strains had pulsed-field gel electrophoresis profiles that were 90% homologous to clinical Ont:H52 strains that had identical phenotypes and genotypes. All Ont:H52 strains had identical single nucleotide polymorphism profiles that are suggestive of a unique clonal group. JF - Applied and Environmental Microbiology AU - Monday, Steven R AU - Keys, Christina AU - Hanson, Patricia AU - Shen, Yuelian AU - Whittam, Thomas S AU - Feng, Peter AD - Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, Maryland 20740. Florida Department of Agriculture and Consumer Services, Tallahassee, Florida 32339. STEC Center, Michigan State University, East Lansing, Michigan 48824 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 3062 EP - 3065 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 4 SN - 0099-2240, 0099-2240 KW - Toxicology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Single-nucleotide polymorphism KW - Escherichia coli KW - Pulsed-field gel electrophoresis KW - Shiga toxin KW - J 02822:Biosynthesis and physicochemical properties KW - X 24490:Other KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17121798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Produce+Isolates+of+the+Escherichia+coli+Ont%3AH52+Serotype+That+Carry+both+Shiga+Toxin+1+and+Stable+Toxin+Genes&rft.au=Monday%2C+Steven+R%3BKeys%2C+Christina%3BHanson%2C+Patricia%3BShen%2C+Yuelian%3BWhittam%2C+Thomas+S%3BFeng%2C+Peter&rft.aulast=Monday&rft.aufirst=Steven&rft.date=2006-04-01&rft.volume=72&rft.issue=4&rft.spage=3062&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serotypes; Single-nucleotide polymorphism; Pulsed-field gel electrophoresis; Shiga toxin; Escherichia coli ER - TY - JOUR T1 - Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study AN - 17120544; 6750392 AB - This study compares the phylogenetic lineages of invasive serotype III group B streptococci (GBS) to those of colonizing strains in order to determine lineages associated with invasive disease. Isolates from 29 infants with early-onset disease (EOD) and from 196 colonized infants, collected in a prospective, multicenter study, were assigned a sequence type (ST) by multilocus sequence typing. Overall, 54.5% of the isolates were in the ST-19 complex, and 40.4% were in the ST-17 complex. Invasive strains were more likely to be in the ST-17 complex than were colonizing strains (59% versus 38%, P = 0.03). After we adjusted for potential confounders, the ST-17 complex was more likely to be associated with EOD than were other lineages (odds ratio = 2.51, 95% confidence interval = 1.02 to 6.20). These data support the hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS. JF - Journal of Clinical Microbiology AU - Lin, Feng-Ying C AU - Whiting, April AU - Adderson, Elisabeth AU - Takahashi, Shinji AU - Dunn, Diane Marie AU - Weiss, Robert AU - Azimi, Parvin H AU - Philips, Joseph BIII AU - Weisman, Leonard E AU - Regan, Joan AU - Clark, Penny AU - Rhoads, George G AU - Frasch, Carl E AU - Troendle, James AU - Moyer, Patricia AU - Bohnsack, John F AD - National Institute of Child Health and Human Development, National Institutes of Health. Center for Biologics Research and Review, Food and Drug Administration, Department of Health and Human Services, Bethesda, Maryland. Department of Pediatrics. Genome Center, University of Utah Health Sciences Center, Salt Lake City, Utah. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee. Division of Microbiology, Joshi-Eiyoh University, Saitama, Japan. Children's Hospital Medical Center of Northern California, Oakland, California. University of Alabama at Birmingham, Birmingham, Alabama. Baylor College of Medicine, Houston, Texas. Columbia University Health Sciences, New York, New York. University of Florida, Gainesville, Florida. University of Dentistry and Medicine of New Jersey, Piscataway, New Jersey Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1257 EP - 1261 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Serotypes KW - Guillain-Barre syndrome KW - Neonates KW - Infants KW - multilocus sequence typing KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17120544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Phylogenetic+Lineages+of+Invasive+and+Colonizing+Strains+of+Serotype+III+Group+B+Streptococci+from+Neonates%3A+a+Multicenter+Prospective+Study&rft.au=Lin%2C+Feng-Ying+C%3BWhiting%2C+April%3BAdderson%2C+Elisabeth%3BTakahashi%2C+Shinji%3BDunn%2C+Diane+Marie%3BWeiss%2C+Robert%3BAzimi%2C+Parvin+H%3BPhilips%2C+Joseph+BIII%3BWeisman%2C+Leonard+E%3BRegan%2C+Joan%3BClark%2C+Penny%3BRhoads%2C+George+G%3BFrasch%2C+Carl+E%3BTroendle%2C+James%3BMoyer%2C+Patricia%3BBohnsack%2C+John+F&rft.aulast=Lin&rft.aufirst=Feng-Ying&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phylogeny; Serotypes; Guillain-Barre syndrome; Neonates; multilocus sequence typing; Infants ER - TY - JOUR T1 - Molecular and Physiological Effects of Mycobacterial oxyR Inactivation AN - 17112055; 6747379 AB - The majority of slow-growing mycobacteria have a functional oxyR, the central regulator of the bacterial oxidative stress response. In contrast, this gene has been inactivated during the evolution of Mycobacterium tuberculosis. Here we inactivated the oxyR gene in Mycobacterium marinum, an organism used to model M. tuberculosis pathogenesis. Inactivation of oxyR abrogated induction of ahpC, a gene encoding alkylhydroperoxide reductase, normally activated upon peroxide challenge. The absence of oxyR also resulted in increased sensitivity to the front-line antituberculosis drug isoniazid. Inactivation of oxyR in M. marinum did not affect either virulence in a fish infection model or survival in human macrophages. Our findings demonstrate, at the genetic and molecular levels, a direct role for OxyR in ahpC regulation in response to oxidative stress. Our study also indicates that oxyR is not critical for virulence in M. marinum. However, oxyR inactivation confers increased sensitivity to isonicotinic acid hydrazide, suggesting that the natural loss of oxyR in the tubercle bacillus contributes to the unusually high sensitivity of M. tuberculosis to isoniazid. JF - Journal of Bacteriology AU - Pagan-Ramos, Eileen AU - Master, Sharon S AU - Pritchett, Christopher L AU - Reimschuessel, Renate AU - Trucksis, Michele AU - Timmins, Graham S AU - Deretic, Vojo AD - Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48105. Department of Molecular Genetics and Microbiology. School of Pharmacy. Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201. Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland 20857. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 2674 EP - 2680 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Macrophages KW - Cell survival KW - Infection KW - Models KW - oxyR gene KW - Virulence KW - reductase KW - Oxidative stress KW - Mycobacterium marinum KW - peroxide KW - Tuberculosis KW - Evolutionary genetics KW - Bacillus KW - Drugs KW - Mycobacterium tuberculosis KW - Isoniazid KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17112055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Molecular+and+Physiological+Effects+of+Mycobacterial+oxyR+Inactivation&rft.au=Pagan-Ramos%2C+Eileen%3BMaster%2C+Sharon+S%3BPritchett%2C+Christopher+L%3BReimschuessel%2C+Renate%3BTrucksis%2C+Michele%3BTimmins%2C+Graham+S%3BDeretic%2C+Vojo&rft.aulast=Pagan-Ramos&rft.aufirst=Eileen&rft.date=2006-04-01&rft.volume=188&rft.issue=7&rft.spage=2674&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Macrophages; Infection; Models; Virulence; oxyR gene; reductase; Oxidative stress; peroxide; Tuberculosis; Evolutionary genetics; Drugs; Isoniazid; Mycobacterium marinum; Bacillus; Mycobacterium tuberculosis ER - TY - JOUR T1 - Risk factors for human herpesvirus 8 seropositivity in the AIDS Cancer Cohort Study AN - 17110107; 6742078 AB - Background: Cigarette smoking has been associated with a decreased risk for AIDS-related and classical KS, but whether it is associated with decreased risk of human herpesvirus 8 (HHV-8) infection is unknown. Study design: We evaluated factors associated with HHV-8 seropositivity in 2795 participants (132 with KS) in the National Cancer Institute AIDS Cancer Cohort, including 1621 men who have sex with men (MSM), 660 heterosexual men and 514 women. Odds ratios (OR) and 95% confidence intervals were estimated using logistic regression models. Results: Among non-KS subjects, HHV-8 seropositivity was 6%, 13% and 29% among women, heterosexual men and MSM, respectively. HHV-8 seropositivity was decreased in heavier (>=1/2 pack/day) compared to lighter smokers among women (5% versus 8%; adjusted OR (aOR) 0.4; 95% CI 0.2-0.8) and MSM (27% versus 32%; aOR 0.7; 95% CI 0.6-1.0), but not among heterosexual men (12% versus 16%; aOR 0.7; 95% CI 0.4-1.2). HHV-8 seroprevalence was increased in heavier (>=1 drink/day) compared to lighter consumers of alcohol among women (16% versus 4%; adjusted OR 5.2; 95% CI 2.3-12), but not among MSM (33% versus 28%; aOR 1.2; 95% CI 0.9-1.6) or heterosexual men (13% versus 13%; aOR 1.1; 95% CI 0.6-2.0). In analyses adjusted for smoking and drinking, HHV-8 seropositivity was positively associated with chlamydia infection (OR=4.3; 95% CI 1.2-13) and with marital status among women p sub(h) sub(e) sub(t) sub(e) sub(r) sub(o) sub(g) sub(e) sub(n) sub(e) sub(i) sub(t) sub(y)=0.03, and with hepatitis (OR=1.6; 95% CI 1.2-2.1), gonorrhea (OR=1.5; 95% CI 1.1-1.9), genital warts (OR=1.5; 95% CI 1.1-2.0) and nitrate inhalant use (OR=1.7; 95% CI 1.3-2.3) among MSM. Conclusions: Inverse association of HHV-8 seropositivity with cigarette smoking may indicate protective effect of tobacco smoke on HHV-8 infection, whereas positive associations with alcohol may reflect either behavioral factors or biological effects modulating susceptibility. Smoking and drinking may influence KS risk, at least in part, by altering the natural history of HHV-8 infection. JF - Journal of Clinical Virology AU - Mbulaiteye, S M AU - Atkinson, JO AU - Whitby, D AU - Wohl, DA AU - Gallant, JE AU - Royal, S AU - Goedert, J J AU - Rabkin, C S AD - National Cancer Institute, Department of Health and Human Services, 6120 Executive Blvd, Executive Plaza South Rm 8006. Mail Stop Center 7248, Rockville, MD 20852, United States, mbulaits@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 442 EP - 449 PB - Elsevier B.V. VL - 35 IS - 4 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Risk assessment KW - Drinking KW - Nitrate KW - Acquired immune deficiency syndrome KW - Beverages KW - Human herpesvirus 8 KW - Infection KW - Cancer KW - Models KW - Hepatitis KW - Smoke KW - Inhalants KW - Warts KW - Risk factors KW - Cigarette smoking KW - Regression analysis KW - alcohols KW - Tobacco KW - Drinking behavior KW - Gonorrhea KW - Consumers KW - Chlamydia KW - Sex KW - V 22006:AIDS: Other aspects KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17110107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Risk+factors+for+human+herpesvirus+8+seropositivity+in+the+AIDS+Cancer+Cohort+Study&rft.au=Mbulaiteye%2C+S+M%3BAtkinson%2C+JO%3BWhitby%2C+D%3BWohl%2C+DA%3BGallant%2C+JE%3BRoyal%2C+S%3BGoedert%2C+J+J%3BRabkin%2C+C+S&rft.aulast=Mbulaiteye&rft.aufirst=S&rft.date=2006-04-01&rft.volume=35&rft.issue=4&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2005.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Drinking; Risk assessment; Nitrate; Acquired immune deficiency syndrome; Beverages; Infection; Cancer; Models; Smoke; Hepatitis; Inhalants; Warts; Risk factors; Cigarette smoking; Tobacco; alcohols; Regression analysis; Drinking behavior; Consumers; Gonorrhea; Sex; Human herpesvirus 8; Chlamydia DO - http://dx.doi.org/10.1016/j.jcv.2005.10.010 ER - TY - JOUR T1 - Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein AN - 17065725; 6698494 AB - Exposures of Sprague-Dawley rats to the soy isoflavone, genistein, throughout the entire lifespan have produced a number of effects on reproductive tissues, immune function, neuroendocrine function and behavior. Our previous studies investigated pharmacokinetics and disposition of genistein during adult and fetal periods and this study describes the internal exposures of post-natal day 10 (PND10) rat pups due to lactational transfer of genistein. Conjugated and aglycone forms of genistein were measured by using LC/MS/MS in serum (PND10) and milk (PND7) from lactating dams consuming a genistein-fortified soy-free diet, and in serum from their pups at a time when milk was the only food source (PND10). This study shows that limited lactational transfer of genistein to rat pups occurs and that internal exposures to the active aglycone form of genistein are generally lower than those measured previously in the fetal period. These results suggest that developmental effects attributable to genistein exposure in our chronic and multi-generation studies are more likely to result from fetal exposures because of the higher levels of the active estrogenic aglycone form of genistein in utero, although the possibility of neonatal responses cannot be excluded. JF - Reproductive Toxicology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Newbold, Retha R AU - Delclos, KBarry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, ddoerge@nctr.fda.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 307 EP - 312 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 21 IS - 3 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Genistein KW - Soy KW - Lactation KW - Neonatal KW - Mass spectrometry KW - Diets KW - Aglycones KW - Milk KW - Life span KW - Disposition KW - Isoflavones KW - Pharmacokinetics KW - Fetuses KW - Soybeans KW - Food sources KW - Isoflavone KW - Neonates KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17065725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Lactational+transfer+of+the+soy+isoflavone%2C+genistein%2C+in+Sprague-Dawley+rats+consuming+dietary+genistein&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BNewbold%2C+Retha+R%3BDelclos%2C+KBarry&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2006-04-01&rft.volume=21&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2005.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Aglycones; Milk; Life span; Disposition; Fetuses; Pharmacokinetics; Isoflavones; Soybeans; Food sources; Isoflavone; Neonates; Genistein DO - http://dx.doi.org/10.1016/j.reprotox.2005.09.007 ER - TY - JOUR T1 - Food labeling: health claims; dietary noncariogenic carbohydrate sweeteners and dental caries. Final rule. AN - 67818586; 16572525 AB - The Food and Drug Administration (FDA) is announcing its decision to authorize the use of a health claim regarding the association between sucralose and the nonpromotion of dental caries. Based on its review of evidence described in the proposed rule and comments submitted on the proposed rule, the agency has concluded that sucralose does not promote dental caries. Therefore, the agency has decided to amend the regulation that authorizes a health claim regarding noncariogenic carbohydrate sweeteners to include sucralose. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 SP - 15559 EP - 15564 VL - 71 IS - 60 SN - 0097-6326, 0097-6326 KW - Cariogenic Agents KW - 0 KW - Sweetening Agents KW - Sucrose KW - 57-50-1 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Fermentation KW - Humans KW - Food Industry -- legislation & jurisprudence KW - Cariogenic Agents -- adverse effects KW - Sweetening Agents -- classification KW - Sweetening Agents -- adverse effects KW - Sucrose -- analogs & derivatives KW - Dental Caries -- prevention & control KW - Advertising as Topic -- legislation & jurisprudence KW - Food Labeling -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67818586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Food+labeling%3A+health+claims%3B+dietary+noncariogenic+carbohydrate+sweeteners+and+dental+caries.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2006-03-29&rft.volume=71&rft.issue=60&rft.spage=15559&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rac GTPase signaling through the PP5 protein phosphatase. AN - 67810890; 16549782 AB - We have investigated the Rac-dependent mechanism of KCNH2 channel stimulation by thyroid hormone in a rat pituitary cell line, GH(4)C(1), with the patch-clamp technique. Here we present physiological evidence for the protein serine/threonine phosphatase, PP5, as an effector of Rac GTPase signaling. We also propose and test a specific molecular mechanism for PP5 stimulation by Rac-GTP. Inhibition of PP5 with the microbial toxin, okadaic acid, blocked channel stimulation by thyroid hormone and by Rac, but signaling was restored by expression of a toxin-insensitive mutant of PP5, Y451A, which we engineered. PP5 is unique among protein phosphatases in that it contains an N-terminal regulatory domain with three tetratricopeptide repeats (TPR) that inhibit its activity. Expression of the TPR domain coupled to GFP blocked channel stimulation by the thyroid hormone. We also show that the published structures of the PP5 TPR domain and the TPR domain of p67, the Rac-binding subunit of NADPH oxidase, superimpose over 92 alpha carbons. Mutation of the PP5 TPR domain at two predicted contact points with Rac-GTP prevents the TPR domain from functioning as a dominant negative and blocks the ability of Y451A to rescue signaling in the presence of okadaic acid. PP5 stimulation by Rac provides a unique molecular mechanism for the antagonism of Rho-dependent signaling through protein kinases in many cellular processes, including metastasis, immune cell chemotaxis, and neuronal development. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gentile, Saverio AU - Darden, Thomas AU - Erxleben, Christian AU - Romeo, Charles AU - Russo, Angela AU - Martin, Negin AU - Rossie, Sandra AU - Armstrong, David L AD - Environmental Biology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 SP - 5202 EP - 5206 VL - 103 IS - 13 SN - 0027-8424, 0027-8424 KW - ERG1 Potassium Channel KW - 0 KW - Ether-A-Go-Go Potassium Channels KW - KCNH2 protein, human KW - Kcnh2 protein, rat KW - Nuclear Proteins KW - Potassium Channels, Voltage-Gated KW - Thyroid Hormones KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Tyrosine KW - 42HK56048U KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - protein phosphatase 5 KW - rac GTP-Binding Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Thyroid Hormones -- pharmacology KW - Models, Molecular KW - Amino Acid Sequence KW - Electrophysiology KW - Protein Structure, Quaternary KW - Ion Channel Gating -- drug effects KW - Rats KW - Patch-Clamp Techniques KW - Sequence Alignment KW - Molecular Sequence Data KW - Okadaic Acid -- pharmacology KW - Tyrosine -- genetics KW - Tyrosine -- metabolism KW - Potassium Channels, Voltage-Gated -- metabolism KW - Cell Line KW - rac GTP-Binding Proteins -- metabolism KW - rac GTP-Binding Proteins -- chemistry KW - Nuclear Proteins -- genetics KW - Phosphoprotein Phosphatases -- metabolism KW - Phosphoprotein Phosphatases -- genetics KW - Phosphoprotein Phosphatases -- chemistry KW - Nuclear Proteins -- chemistry KW - Nuclear Proteins -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Rac+GTPase+signaling+through+the+PP5+protein+phosphatase.&rft.au=Gentile%2C+Saverio%3BDarden%2C+Thomas%3BErxleben%2C+Christian%3BRomeo%2C+Charles%3BRusso%2C+Angela%3BMartin%2C+Negin%3BRossie%2C+Sandra%3BArmstrong%2C+David+L&rft.aulast=Gentile&rft.aufirst=Saverio&rft.date=2006-03-28&rft.volume=103&rft.issue=13&rft.spage=5202&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-10 N1 - Date created - 2006-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2000 Oct;6(4):899-907 [11090627] Trends Biochem Sci. 2005 Apr;30(4):194-204 [15817396] Brain Res Mol Brain Res. 2001 Jun 20;90(2):101-9 [11406288] EMBO J. 2001 Nov 1;20(21):6028-36 [11689443] J Biol Chem. 2001 Nov 23;276(47):44078-82 [11535607] Trends Cell Biol. 2001 Dec;11(12):471-7 [11719051] Curr Biol. 2002 Jan 8;12(1):27-33 [11790300] Trends Neurosci. 2002 Apr;25(4):191-9 [11998687] Curr Biol. 2002 Aug 6;12(15):1353-8 [12176367] Curr Med Chem. 2002 Nov;9(22):2055-75 [12369870] FEBS Lett. 2003 Jul 3;546(1):93-7 [12829242] Physiol Rev. 2003 Jul;83(3):965-1016 [12843413] Physiol Rev. 2003 Oct;83(4):1325-58 [14506307] Curr Opin Cell Biol. 2003 Oct;15(5):583-9 [14519393] Science. 2003 Nov 14;302(5648):1215-7 [14615541] Trends Biochem Sci. 2003 Dec;28(12):655-62 [14659697] Cell. 2004 Jan 23;116(2):167-79 [14744429] J Cell Mol Med. 2004 Jan-Mar;8(1):22-30 [15090257] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Trends Neurosci. 1992 Oct;15(10):403-8 [1279866] FEBS Lett. 1993 Dec 28;336(3):433-9 [8282106] Biochemistry. 1996 Feb 6;35(5):1606-11 [8634292] J Biol Chem. 1996 Dec 13;271(50):32315-20 [8943293] FEBS Lett. 1997 Jan 2;400(1):136-40 [9000529] J Biol Chem. 1997 Sep 5;272(36):22464-71 [9278397] EMBO J. 1998 Mar 2;17(5):1192-9 [9482716] J Physiol. 1998 Aug 15;511 ( Pt 1):3-14 [9679158] J Biol Chem. 1999 Aug 13;274(33):23666-72 [10438550] J Biol Chem. 1999 Sep 24;274(39):27457-62 [10488078] Genes Dev. 2005 Jan 1;19(1):1-49 [15630019] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5197-201 [16549781] J Biol Chem. 2005 Jan 21;280(3):1790-6 [15546861] EMBO J. 2005 Jan 12;24(1):1-10 [15577939] J Biol Chem. 2005 Feb 11;280(6):4532-43 [15579468] Biochem J. 2005 Mar 1;386(Pt 2):201-14 [15548136] Trends Cell Biol. 2005 Mar;15(3):163-71 [15752980] Trends Endocrinol Metab. 2001 Jan-Feb;12(1):28-32 [11137038] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Small Interfering RNAs and Vaccines: Protection Against Influenza by Targeting Conserved Components T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39942204; 4143210 JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - Epstein, Suzanne L Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Vaccines KW - SiRNA KW - Influenza KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=Small+Interfering+RNAs+and+Vaccines%3A+Protection+Against+Influenza+by+Targeting+Conserved+Components&rft.au=Epstein%2C+Suzanne+L&rft.aulast=Epstein&rft.aufirst=Suzanne&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of CpG Oligonucleotides to Improve Host Protection from Infectious Pathogens T2 - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AN - 39931549; 4143158 JF - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AU - Klinman, Dennis M Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Pathogens KW - Oligonucleotides KW - CpG islands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.atitle=Use+of+CpG+Oligonucleotides+to+Improve+Host+Protection+from+Infectious+Pathogens&rft.au=Klinman%2C+Dennis+M&rft.aulast=Klinman&rft.aufirst=Dennis&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=801 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unusual Trematode Egg Nests in the Stomach Tissues of Goggle-Eyed Scad, Selar crumenophthalmus (Bloch, 1793) T2 - 31st Eastern Fish Health Workshop (EFHW 2006) AN - 40012076; 4191643 JF - 31st Eastern Fish Health Workshop (EFHW 2006) AU - Matysczak, Jennifer AU - Clauss, Tonya AU - Krum, Howard AU - Nietfeld, Theresa AU - Yanong, Roy P.E. AU - Dove, Alistair Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Nests KW - Stomach KW - Selar crumenophthalmus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Eastern+Fish+Health+Workshop+%28EFHW+2006%29&rft.atitle=Unusual+Trematode+Egg+Nests+in+the+Stomach+Tissues+of+Goggle-Eyed+Scad%2C+Selar+crumenophthalmus+%28Bloch%2C+1793%29&rft.au=Matysczak%2C+Jennifer%3BClauss%2C+Tonya%3BKrum%2C+Howard%3BNietfeld%2C+Theresa%3BYanong%2C+Roy+P.E.%3BDove%2C+Alistair&rft.aulast=Matysczak&rft.aufirst=Jennifer&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Eastern+Fish+Health+Workshop+%28EFHW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.lsc.usgs.gov/FHB/workshops/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Chemists in the FDA Drug Approval Process T2 - 231st National Meeting of the American Chemical Society AN - 40127679; 4116559 JF - 231st National Meeting of the American Chemical Society AU - Furness, M Scott Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Drugs KW - FDA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40127679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=The+Role+of+Chemists+in+the+FDA+Drug+Approval+Process&rft.au=Furness%2C+M+Scott&rft.aulast=Furness&rft.aufirst=M&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Symbiotic relationship of pharmacogenetics and drugs of abuse. AN - 67828507; 16584126 AB - Pharmacogenetics/pharmacogenomics is the study of how genetic variation affects pharmacology, the use of drugs to treat disease. When drug responses are predicted in advance, it is easier to tailor medications to different diseases and individuals. Pharmacogenetics provides the tools required to identify genetic predictors of probable drug response, drug efficacy, and drug-induced adverse events-identifications that would ideally precede treatment decisions. Drug abuse and addiction genetic data have advanced the field of pharmacogenetics in general. Although major findings have emerged, pharmacotherapy remains hindered by issues such as adverse events, time lag to drug efficacy, and heterogeneity of the disorders being treated. The sequencing of the human genome and high-throughput technologies are enabling pharmacogenetics to have greater influence on treatment approaches. This review highlights key studies and identifies important genes in drug abuse pharmacogenetics that provide a basis for better diagnosis and treatment of drug abuse disorders. JF - The AAPS journal AU - Rutter, Joni L AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Boulevard, Bethesda, MD 20892, USA. jrutter@mail.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - E174 EP - E184 VL - 8 IS - 1 KW - Street Drugs KW - 0 KW - Index Medicus KW - Humans KW - Genetic Variation -- genetics KW - Pharmacogenetics -- methods KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Symbiotic+relationship+of+pharmacogenetics+and+drugs+of+abuse.&rft.au=Rutter%2C+Joni+L&rft.aulast=Rutter&rft.aufirst=Joni&rft.date=2006-03-24&rft.volume=8&rft.issue=1&rft.spage=E174&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 2005 Jun;81(2):381-6 [15925402] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] J Med Genet. 2005 Jul;42(7):583-7 [15994880] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] J Neurochem. 2005 Jul;94(2):352-9 [15998286] Pharmacogenomics J. 2005;5(4):218-20 [16041391] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12938-43 [16118273] J Biol Chem. 2005 Sep 23;280(38):32618-24 [16046395] PLoS Med. 2005 Sep;2(9):e266; 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author reply 1445-7 [15178784] Arch Gen Psychiatry. 2004 Jun;61(6):597-606 [15184239] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Arch Gen Psychiatry. 1998 Nov;55(11):973-9 [9819065] J Am Med Inform Assoc. 2005 Mar-Apr;12(2):121-9 [15561790] J Pain. 2005 Mar;6(3):159-67 [15772909] Pharmacogenomics J. 2005;5(2):89-95 [15772696] Am J Hum Genet. 2005 May;76(5):859-64 [15759211] Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):5-9 [15729709] Trends Pharmacol Sci. 2005 Jun;26(6):311-7 [15925706] Neuropsychopharmacology. 2005 Jul;30(7):1374-82 [15827573] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates AN - 17068488; 6698543 AB - The P/C gene of human parainfluenza virus type 1 (HPIV1) encodes a nested set of related accessory C proteins, C'/C/Y1/Y2, which have been shown in other paramyxoviruses to have a role in evasion of the type I interferon (IFN) response following virus infection. We previously demonstrated that a set of two amino acid substitutions, C super(R84G)/HN super(T553A), and a separate amino acid substitution, C super(F170S), are independently attenuating for HPIV1 in African green monkeys (AGMs). However, in each case the attenuation (att) phenotype is vulnerable to reversion by a single nucleotide change back to wild type. Using reverse genetics, recombinant HPIV1 (rHPIV1) vaccine candidates were generated that were designed for increased genetic and phenotypic stability by: (i) creating a two-amino acid deletion and substitution at the site of the C super(F170S) mutation, yielding C super( Delta 170); (ii) introducing a six amino acid deletion in the N-terminal region of C, C super( Delta 10-15); and (iii) combining these stable deletion mutations with the att C super(R84G)/HN super(T553A) mutation. The resulting rHPIV1 vaccine candidates were evaluated for attenuation in hamsters and AGMs and for immunogenicity and protective efficacy in AGMs. The C super( Delta 10- 15) mutation was attenuating in hamsters but not in AGMs, and likely will be of limited value for an HPIV1 vaccine. Conversely, the C super(R84G)/HN super(T553A) mutation set was attenuating in AGMs but not in hamsters. Thus, these two mutations demonstrated reciprocal host range phenotypes involving different regions of C. The C super( Delta 170) mutation conferred a significant level of attenuation in hamsters and AGMs that closely resembled that of C super(F170S) and will be of particular utility for vaccine development because it involves a deletion of six nucleotides rendering it highly refractory to reversion. The combination of the C super(R84G)/HN super(T553A) mutation set and the C super( Delta 170) deletion mutation yielded a virus, rC super(R84G/ Delta 170)HN super(T553A), that exhibited a satisfactory level of attenuation in hamsters and AGMs and was immunogenic and highly protective against HPIV1 wt challenge. This virus will be evaluated clinically as a live intranasal HPIV1 vaccine, one that can be further attenuated as necessary by the introduction of additional stabilized att mutations previously developed in the L protein. JF - Vaccine AU - Bartlett, Emmalene J AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Collins, Peter L AU - Murphy, Brian R AU - Skiadopoulos, Mario H AD - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bldg 50, Room 6511, 50 South Drive MSC 8007; Bethesda, MD 20892-8007, USA, EBartlett@niaid.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2674 EP - 2684 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Human parainfluenza virus KW - Attenuating mutations KW - Interferon antagonist KW - Vaccine candidates KW - Non-human primate study KW - double prime L protein KW - Host range KW - Amino acid substitution KW - Reversion KW - double prime C gene KW - Infection KW - Nucleotides KW - Parainfluenza virus KW - Parainfluenza KW - Interferon KW - Gene deletion KW - Immunogenicity KW - double prime C protein KW - Vaccines KW - Mutation KW - W3 33365:Vaccines (other) KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17068488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Introducing+point+and+deletion+mutations+into+the+P%2FC+gene+of+human+parainfluenza+virus+type+1+%28HPIV1%29+by+reverse+genetics+generates+attenuated+and+efficacious+vaccine+candidates&rft.au=Bartlett%2C+Emmalene+J%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSkiadopoulos%2C+Mario+H&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2674&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.10.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - double prime L protein; Amino acid substitution; Host range; Reversion; Infection; double prime C gene; Nucleotides; Parainfluenza; Interferon; Gene deletion; Immunogenicity; double prime C protein; Vaccines; Mutation; Parainfluenza virus DO - http://dx.doi.org/10.1016/j.vaccine.2005.10.047 ER - TY - JOUR T1 - Adverse events after hepatitis A B combination vaccine AN - 17066297; 6698544 AB - In May 2001, the U.S. Food and Drug Administration (FDA) approved Hepatitis A Inactivated and Hepatitis B Recombinant Vaccine (HEPAB) for immunization of adults. From May 2001 to September 2003, the Vaccine Adverse Event Reporting System (VAERS) received 305 reports of adverse events after HEPAB. Many events were similar to those reported after the monovalent hepatitis A and B vaccines. Non-serious events included constitutional symptoms and local reactions. Serious events included neurologic, hepatobiliary, and dermatologic conditions, and detailed medical and epidemiological review did not suggest a clear pattern of evidence supporting a causal relationship with the vaccine, except for injection site reactions and some allergic reactions. JF - Vaccine AU - Woo, Emily Jane AU - Miller, Nancy B AU - Ball, Robert AD - Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA, wooj@cber.fda.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2685 EP - 2691 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - adverse effects KW - Virology & AIDS Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Twinrix super([registered]) KW - Hepatitis A KW - Hepatitis B KW - Adverse event KW - Hypersensitivity KW - Hepatitis B virus KW - Reviews KW - Hepatitis A virus KW - Vaccines KW - Immunization KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06300:Experimental: Immediate KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17066297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Adverse+events+after+hepatitis+A+B+combination+vaccine&rft.au=Woo%2C+Emily+Jane%3BMiller%2C+Nancy+B%3BBall%2C+Robert&rft.aulast=Woo&rft.aufirst=Emily&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2685&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.10.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Reviews; Hepatitis B; Hepatitis A; Vaccines; Immunization; Hepatitis B virus; Hepatitis A virus DO - http://dx.doi.org/10.1016/j.vaccine.2005.10.049 ER - TY - CPAPER T1 - FDA Initiatives in Risk Communication: Providing Clinicians with Safety Information for the Medications and Medical Devices Used in Daily Patient Care T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39966303; 4150729 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Marks, Norman Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Communication KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=FDA+Initiatives+in+Risk+Communication%3A+Providing+Clinicians+with+Safety+Information+for+the+Medications+and+Medical+Devices+Used+in+Daily+Patient+Care&rft.au=Marks%2C+Norman&rft.aulast=Marks&rft.aufirst=Norman&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice. AN - 67930959; 16336979 AB - Deficiencies in DNA mismatch repair (MMR) result in predisposition to neoplasia in both rodents and humans. Pms2 is one of the several proteins involved in the eukaryotic MMR system. In order to determine the effect of Pms2-deficiency on mutation, we measured mutant frequencies in the endogenous Hprt gene of lymphocytes from male Pms2(-/-), Pms2(+/-), and Pms2(+/+) mice. Spleens were removed from mice of various ages and lymphocytes isolated from spleens were cultured to determine the frequency of 6-thioguanine-resistant mutants. Mean mutant frequencies in Pms2(-/-) mice at 6, 10, 18, and 34 weeks of age [42.6 x 10(-6) (n=6), 38.5 x 10(-6) (n=6), 58.2 x 10(-6) (n=9), and 49.1 x 10(-6) (n=5), respectively] were significantly higher than those of comparably aged Pms2(+/+) and Pms2(+/-) mice (all less than 3 x 10(-6)). Mutant clones from the mice were expanded, RNA extracted, and Hprt cDNA amplified by RT-PCR. DNA sequencing analysis of 221 mutant cDNAs from the three different Pms2 genotypes identified 182 clones with independent mutations, including five clones that contained multiple mutations. When compared to the mutational spectrum observed in Pms2(+/+) and Pms2(+/-) mice, the mutational spectrum for Pms2(-/-) mice was significantly different. The Pms2(-/-) mutational analysis indicated that loss of the Pms2 protein causes increases in the frequencies of strand-slippage-type frameshift mutations and of A:T --> G:C transitions in the Hprt gene. The absolute frequencies of A:T --> G:C transitions in MMR-deficient mice suggest increases in this mutation may be a common feature of MMR-deficient mice, not just of Pms2-deficient mice, and may be related to the cancer predisposition that results from loss of MMR function. JF - Mutation research AU - Shaddock, Joseph G AU - Dobrovolsky, Vasily N AU - Mittelstaedt, Roberta A AU - Heflich, Robert H AU - Parsons, Barbara L AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA. Y1 - 2006/03/20/ PY - 2006 DA - 2006 Mar 20 SP - 69 EP - 79 VL - 595 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA-Binding Proteins KW - 0 KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Pms2 protein, mouse KW - Mismatch Repair Endonuclease PMS2 KW - EC 3.6.1.3 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Thioguanine KW - FTK8U1GZNX KW - Index Medicus KW - DNA Repair -- genetics KW - Animals KW - Spleen -- cytology KW - Cells, Cultured KW - DNA Mutational Analysis KW - Mice, Inbred C57BL KW - Mice KW - Base Pair Mismatch -- genetics KW - Male KW - Thioguanine -- pharmacology KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - DNA-Binding Proteins -- deficiency KW - Adenosine Triphosphatases -- deficiency KW - Mutation -- genetics KW - Lymphocytes -- metabolism KW - Mutagenesis -- genetics KW - Lymphocytes -- drug effects KW - DNA Repair Enzymes -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Frequency+and+types+of+spontaneous+Hprt+lymphocyte+mutations+in+Pms2-deficient+mice.&rft.au=Shaddock%2C+Joseph+G%3BDobrovolsky%2C+Vasily+N%3BMittelstaedt%2C+Roberta+A%3BHeflich%2C+Robert+H%3BParsons%2C+Barbara+L&rft.aulast=Shaddock&rft.aufirst=Joseph&rft.date=2006-03-20&rft.volume=595&rft.issue=1-2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blood pressure as an example of a biomarker that functions as a surrogate. AN - 67825200; 16584122 AB - There are many important uses of biomarkers in drug development. An area of particular interest is the use of biomarkers as surrogate end points. Only a small minority of biomarkers are established surrogate end points. Blood pressure is an example of a surrogate end point accepted by both clinicians and regulators. It was a plausible surrogate because of the large epidemiologic databases demonstrating a correlation between elevated blood pressures and adverse cardiovascular outcomes. That plausibility has been supported, however, by the numerous placebo-controlled outcome studies evaluating several pharmacologically distinct agents that showed an effect on stroke and coronary heart disease outcomes from lowering blood pressure. JF - The AAPS journal AU - Desai, Mehul AU - Stockbridge, Norman AU - Temple, Robert AD - Food and Drug Administration, Division of Cardiovascular and Renal Products (HFD-110), Bldg 22, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. desaim@cder.fda.gov Y1 - 2006/03/10/ PY - 2006 DA - 2006 Mar 10 SP - E146 EP - E152 VL - 8 IS - 1 KW - Index Medicus KW - Animals KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Hypertension -- chemically induced KW - Blood Pressure -- physiology KW - Hypertension -- physiopathology KW - Hypertension -- diagnosis KW - Hypertension -- mortality KW - Blood Pressure -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67825200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Blood+pressure+as+an+example+of+a+biomarker+that+functions+as+a+surrogate.&rft.au=Desai%2C+Mehul%3BStockbridge%2C+Norman%3BTemple%2C+Robert&rft.aulast=Desai&rft.aufirst=Mehul&rft.date=2006-03-10&rft.volume=8&rft.issue=1&rft.spage=E146&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1967 Dec 11;202(11):1028-34 [4862069] N Engl J Med. 2003 Feb 13;348(7):583-92 [12584366] JAMA. 1970 Aug 17;213(7):1143-52 [4914579] Lancet. 1974 Aug 24;2(7878):431-3 [4137077] JAMA. 1979 Dec 7;242(23):2562-71 [490882] Lancet. 1980 Jun 14;1(8181):1261-7 [6104081] Lancet. 1985 Jun 15;1(8442):1349-54 [2861311] Br Med J (Clin Res Ed). 1985 Jul 13;291(6488):97-104 [2861880] Stat Med. 1989 Apr;8(4):431-40 [2727467] Lancet. 1990 Mar 31;335(8692):765-74 [1969518] N Engl J Med. 1991 Mar 21;324(12):781-8 [1900101] JAMA. 1991 Jun 26;265(24):3255-64 [2046107] Lancet. 1991 Nov 23;338(8778):1281-5 [1682683] N Engl J Med. 1991 Nov 21;325(21):1468-75 [1944425] Arch Intern Med. 1992 Jan;152(1):56-64 [1728930] BMJ. 1992 Feb 15;304(6824):405-12 [1445513] Fed Regist. 1992 Dec 11;57(239):58942-60 [10123232] JAMA. 1996 May 22-29;275(20):1571-6 [8622248] Ann Intern Med. 1996 Oct 1;125(7):605-13 [8815760] Lancet. 1997 Sep 13;350(9080):757-64 [9297994] Lancet. 1998 Mar 28;351(9107):934-9 [9734939] BMJ. 1998 Sep 12;317(7160):703-13 [9732337] JAMA. 1999 Aug 25;282(8):790-5 [10463719] Lancet. 2005 Sep 10-16;366(9489):895-906 [16154016] Br Med J (Clin Res Ed). 1986 Nov 1;293(6555):1145-51 [3094811] N Engl J Med. 2000 Jan 6;342(1):1-8 [10620642] N Engl J Med. 2000 Jan 20;342(3):145-53 [10639539] JAMA. 2000 Apr 19;283(15):1967-75 [10789664] Clin Pharmacol Ther. 2001 Mar;69(3):89-95 [11240971] N Engl J Med. 2001 Sep 20;345(12):851-60 [11565517] Lancet. 2002 Mar 23;359(9311):995-1003 [11937178] JAMA. 2002 Dec 18;288(23):2981-97 [12479763] Bull N Y Acad Med. 1969 Sep;45(9):902-9 [5257769] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Transition of Biologics from Animal to Humans T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40117300; 4079232 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Green, M David Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40117300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Transition+of+Biologics+from+Animal+to+Humans&rft.au=Green%2C+M+David&rft.aulast=Green&rft.aufirst=M&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDAs Role in Crisis Management T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40117204; 4079197 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Lushniak, Boris D Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40117204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=FDAs+Role+in+Crisis+Management&rft.au=Lushniak%2C+Boris+D&rft.aulast=Lushniak&rft.aufirst=Boris&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of the Exploratory IND in Translational Medicine T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40109904; 4079242 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Jacobson-Kram, David Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Translation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40109904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Application+of+the+Exploratory+IND+in+Translational+Medicine&rft.au=Jacobson-Kram%2C+David&rft.aulast=Jacobson-Kram&rft.aufirst=David&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lessons Learned from the Pediatric Initiative Murphys Laws in Action T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40109698; 4079174 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Murphy, Shirley Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40109698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Lessons+Learned+from+the+Pediatric+Initiative+Murphys+Laws+in+Action&rft.au=Murphy%2C+Shirley&rft.aulast=Murphy&rft.aufirst=Shirley&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Perspective and Next Steps T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40109628; 4079164 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Lesko, Lawrence J Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40109628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=FDA+Perspective+and+Next+Steps&rft.au=Lesko%2C+Lawrence+J&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Model Based Drug Development Applied to Regulatory Recommendations and Decisions T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40074840; 4079202 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Powell, Robert Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Drug development KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40074840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Model+Based+Drug+Development+Applied+to+Regulatory+Recommendations+and+Decisions&rft.au=Powell%2C+Robert&rft.aulast=Powell&rft.aufirst=Robert&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Governments Role in Public Health Crises T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40066834; 4079198 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Carmona, Richard H Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Governments+Role+in+Public+Health+Crises&rft.au=Carmona%2C+Richard+H&rft.aulast=Carmona&rft.aufirst=Richard&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Taxonomy of Proof-of-Concepts Studies T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40066418; 4079161 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Stanski, Donald R Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Taxonomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Taxonomy+of+Proof-of-Concepts+Studies&rft.au=Stanski%2C+Donald+R&rft.aulast=Stanski&rft.aufirst=Donald&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Results of 5 Year GPRA Immunization of Medicaid Two-Year-Old Beneficiary Study T2 - 40th National Immunization Conference (NIC 2006) AN - 39797942; 4079454 JF - 40th National Immunization Conference (NIC 2006) AU - Murphy, Linda S AU - Fenlon, Nancy E Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Immunization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39797942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+National+Immunization+Conference+%28NIC+2006%29&rft.atitle=Results+of+5+Year+GPRA+Immunization+of+Medicaid+Two-Year-Old+Beneficiary+Study&rft.au=Murphy%2C+Linda+S%3BFenlon%2C+Nancy+E&rft.aulast=Murphy&rft.aufirst=Linda&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+National+Immunization+Conference+%28NIC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2006/techprogram/MEETING.HTM LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring Immunization Coverage for American Indian and Alaska Native Children T2 - 40th National Immunization Conference (NIC 2006) AN - 39698652; 4079471 JF - 40th National Immunization Conference (NIC 2006) AU - Groom, Amy V Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - USA, Alaska KW - Children KW - Immunization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39698652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+National+Immunization+Conference+%28NIC+2006%29&rft.atitle=Measuring+Immunization+Coverage+for+American+Indian+and+Alaska+Native+Children&rft.au=Groom%2C+Amy+V&rft.aulast=Groom&rft.aufirst=Amy&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+National+Immunization+Conference+%28NIC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2006/techprogram/MEETING.HTM LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Household Reported Influenza Vaccination Among Children Aged 7-23 Months, National Immunization Survey, 2004 T2 - 40th National Immunization Conference (NIC 2006) AN - 39698429; 4079369 JF - 40th National Immunization Conference (NIC 2006) AU - Shaw, Kate M AU - McCauley, Mary M AU - Singleton, James A Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Children KW - Immunization KW - Vaccination KW - Influenza KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39698429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+National+Immunization+Conference+%28NIC+2006%29&rft.atitle=Household+Reported+Influenza+Vaccination+Among+Children+Aged+7-23+Months%2C+National+Immunization+Survey%2C+2004&rft.au=Shaw%2C+Kate+M%3BMcCauley%2C+Mary+M%3BSingleton%2C+James+A&rft.aulast=Shaw&rft.aufirst=Kate&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+National+Immunization+Conference+%28NIC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2006/techprogram/MEETING.HTM LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Concomitant In Vivo Exposure of Young Male Adult Rats to the Pesticide Methoxychlor (M) and the Antiestrogen Ici 182,780 (Ici) Does not Alter the Declines in Seminal Vesicle (Sv) Weight, Serum Testosterone (T) Level, Ex Vivo Leydig Cell (Lc) T Formation, or Ex Vivo Lc P450 Cholesterol Side-Chain Cleavage (P450Scc) Activity Exerted by Treament With M Alone. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40005337; 4146612 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Murono, E P AU - Derk, R C AU - Akgul, Y Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pesticides KW - Rats KW - Seminal vesicle KW - Leydig cells KW - Testosterone KW - Antiestrogens KW - Cholesterol KW - Methoxychlor KW - Sex hormones KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Concomitant+In+Vivo+Exposure+of+Young+Male+Adult+Rats+to+the+Pesticide+Methoxychlor+%28M%29+and+the+Antiestrogen+Ici+182%2C780+%28Ici%29+Does+not+Alter+the+Declines+in+Seminal+Vesicle+%28Sv%29+Weight%2C+Serum+Testosterone+%28T%29+Level%2C+Ex+Vivo+Leydig+Cell+%28Lc%29+T+Formation%2C+or+Ex+Vivo+Lc+P450+Cholesterol+Side-Chain+Cleavage+%28P450Scc%29+Activity+Exerted+by+Treament+With+M+Alone.&rft.au=Murono%2C+E+P%3BDerk%2C+R+C%3BAkgul%2C+Y&rft.aulast=Murono&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temperature and Neurotoxicity - Lessons from the Amphetamines T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40002336; 4146359 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Miller, D B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Temperature effects KW - Neurotoxicity KW - Amphetamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Temperature+and+Neurotoxicity+-+Lessons+from+the+Amphetamines&rft.au=Miller%2C+D+B&rft.aulast=Miller&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Hepatic Enzyme Expression by P-Nonylphenol (NP)is Modulated by Diet in Male Sprague-Dawley Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39963025; 4146258 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Fu, X. AU - Cooper, S M AU - Delclos, K B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Diets KW - Enzymes KW - Rats KW - P-Nonylphenol KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39963025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Induction+of+Hepatic+Enzyme+Expression+by+P-Nonylphenol+%28NP%29is+Modulated+by+Diet+in+Male+Sprague-Dawley+Rats&rft.au=Fu%2C+X.%3BCooper%2C+S+M%3BDelclos%2C+K+B&rft.aulast=Fu&rft.aufirst=X.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drug-Induced Vasculitis: FDA's Perspective and the Path Forward T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39947203; 4146721 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Papoian, T AU - Goodsaid, F Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - FDA KW - Vasculitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39947203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Drug-Induced+Vasculitis%3A+FDA%27s+Perspective+and+the+Path+Forward&rft.au=Papoian%2C+T%3BGoodsaid%2C+F&rft.aulast=Papoian&rft.aufirst=T&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Murine Models to Understand the Immunologic Basis of Toluene Diisocyanate Asthma. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39945907; 4146339 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Johnson, V J AU - Luster, M I Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Respiratory diseases KW - Asthma KW - Toluene KW - Animal models KW - Toluene diisocyanate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Using+Murine+Models+to+Understand+the+Immunologic+Basis+of+Toluene+Diisocyanate+Asthma.&rft.au=Johnson%2C+V+J%3BLuster%2C+M+I&rft.aulast=Johnson&rft.aufirst=V&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Quantitative Comparison of Dose-Response Models for Methylmercury and Neurobehavioral Development. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39944171; 4146677 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Carrington, C D AU - Bolger, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Dose-response effects KW - Methyl mercury KW - Dimethylmercury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Quantitative+Comparison+of+Dose-Response+Models+for+Methylmercury+and+Neurobehavioral+Development.&rft.au=Carrington%2C+C+D%3BBolger%2C+M&rft.aulast=Carrington&rft.aufirst=C&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiles in Tattooed Skin of SKH-1 Hairless Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39936030; 4144675 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Gopee, N V AU - Desai, V G AU - Miller, B J AU - Fuscoe, J C AU - Tong, W AU - Fang, H AU - Wamer, W G AU - Howard, P C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Skin KW - Mice KW - Gene expression KW - Hairless UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39936030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Gene+Expression+Profiles+in+Tattooed+Skin+of+SKH-1+Hairless+Mice&rft.au=Gopee%2C+N+V%3BDesai%2C+V+G%3BMiller%2C+B+J%3BFuscoe%2C+J+C%3BTong%2C+W%3BFang%2C+H%3BWamer%2C+W+G%3BHoward%2C+P+C&rft.aulast=Gopee&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Age-Dependent Nephrotoxicity of Gentamicin Using Gene Expression Biomarkers T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39932154; 4145454 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Rosenzweig, B A AU - Thompson, K AU - Hanig, J AU - Espandiari, P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Gene expression KW - Gentamicin KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Evaluation+of+the+Age-Dependent+Nephrotoxicity+of+Gentamicin+Using+Gene+Expression+Biomarkers&rft.au=Rosenzweig%2C+B+A%3BThompson%2C+K%3BHanig%2C+J%3BEspandiari%2C+P&rft.aulast=Rosenzweig&rft.aufirst=B&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Chronic, Low-Dose Acrylamide Treatment on Spatial Learning and Neurodevelopment in Fischer 344 Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39931370; 4145147 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Garey, J AU - Ferguson, S A AU - Paule, M G Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Rats KW - Acrylamide KW - Spatial memory KW - Spatial discrimination learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Effects+of+Chronic%2C+Low-Dose+Acrylamide+Treatment+on+Spatial+Learning+and+Neurodevelopment+in+Fischer+344+Rats&rft.au=Garey%2C+J%3BFerguson%2C+S+A%3BPaule%2C+M+G&rft.aulast=Garey&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Forced Exercise Attenuates Kainic Acid-Induced Neurotoxicity Independent of Changes in Plasma or Brain Levels of Insulin-Like Growth Factor-1. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39931070; 4144431 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Benkovic, S A AU - O'Callaghan, J P AU - Miller, D B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Neurotoxicity KW - Brain KW - Insulin-like growth factor I KW - Physical training UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Chronic+Forced+Exercise+Attenuates+Kainic+Acid-Induced+Neurotoxicity+Independent+of+Changes+in+Plasma+or+Brain+Levels+of+Insulin-Like+Growth+Factor-1.&rft.au=Benkovic%2C+S+A%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Alterations in Rat Liver Microarray Data Induced by Tissue Handling T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39930979; 4144407 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Pine, P AU - Rosenzweig, B A AU - Turpaz, Y AU - Thompson, K Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Liver KW - Handling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Characterization+of+Alterations+in+Rat+Liver+Microarray+Data+Induced+by+Tissue+Handling&rft.au=Pine%2C+P%3BRosenzweig%2C+B+A%3BTurpaz%2C+Y%3BThompson%2C+K&rft.aulast=Pine&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Reported Active Metabolite of the Pesticide Methoxychlor(MC), 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), Inhibits Androgen Production by Rat Ovarian Theca Interstitial (TI) Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39930009; 4145708 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Akgul, Y AU - Derk, R C AU - Murono, E P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pesticides KW - Metabolites KW - Theca KW - Androgens KW - Sex hormones KW - Interstitial environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Reported+Active+Metabolite+of+the+Pesticide+Methoxychlor%28MC%29%2C+2%2C2-bis%28p-hydroxyphenyl%29-1%2C1%2C1-trichloroethane+%28HPTE%29%2C+Inhibits+Androgen+Production+by+Rat+Ovarian+Theca+Interstitial+%28TI%29+Cells&rft.au=Akgul%2C+Y%3BDerk%2C+R+C%3BMurono%2C+E+P&rft.aulast=Akgul&rft.aufirst=Y&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Changes in Hippocampal Gene Expression Associated with the Behavioral Toxicity Caused by Chronic Developmental Ketamine or Remacemide Treatment in Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39929942; 4145149 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Wright, L K AU - Patterson, T A AU - Pearson, E AU - Hammond, T G AU - Paule, M G Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Rats KW - Gene expression KW - Hippocampus KW - Ketamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Evaluation+of+Changes+in+Hippocampal+Gene+Expression+Associated+with+the+Behavioral+Toxicity+Caused+by+Chronic+Developmental+Ketamine+or+Remacemide+Treatment+in+Rats&rft.au=Wright%2C+L+K%3BPatterson%2C+T+A%3BPearson%2C+E%3BHammond%2C+T+G%3BPaule%2C+M+G&rft.aulast=Wright&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Effects on Cell Proliferation and Apoptosis in p-Nonylphenol (NP) Induced Polycystic Kidney Disease (PKD) in Male Sprague-Dawley Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39928672; 4145785 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Cooper, S M AU - Fu, X. AU - Muskhelishvili, L AU - Latendresse, J R AU - Delclos, K B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Kidneys KW - Rats KW - Cell proliferation KW - Polycystic kidney KW - P-Nonylphenol KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Dietary+Effects+on+Cell+Proliferation+and+Apoptosis+in+p-Nonylphenol+%28NP%29+Induced+Polycystic+Kidney+Disease+%28PKD%29+in+Male+Sprague-Dawley+Rats&rft.au=Cooper%2C+S+M%3BFu%2C+X.%3BMuskhelishvili%2C+L%3BLatendresse%2C+J+R%3BDelclos%2C+K+B&rft.aulast=Cooper&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Gestational and Neonatal Exposure to Genistein on the Developments of Ovary and Uterus in Prepubertal Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39928359; 4145719 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kim, S AU - Lee, R AU - Rhee, G AU - Kwack, S AU - Seok, J AU - Lim, K AU - Kang, J AU - Chung, J AU - Kim, J AU - Cho, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Rats KW - Ovaries KW - Uterus KW - Genistein KW - Neonates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Effects+of+Gestational+and+Neonatal+Exposure+to+Genistein+on+the+Developments+of+Ovary+and+Uterus+in+Prepubertal+Rats&rft.au=Kim%2C+S%3BLee%2C+R%3BRhee%2C+G%3BKwack%2C+S%3BSeok%2C+J%3BLim%2C+K%3BKang%2C+J%3BChung%2C+J%3BKim%2C+J%3BCho%2C+D&rft.aulast=Kim&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Perspective on Peroxisome Proliferator-Activated Receptor (PPAR) Induced Tumors Including Hemangiosarcoma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39928059; 4145986 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - ElHage, J D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Peroxisome proliferator-activated receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Regulatory+Perspective+on+Peroxisome+Proliferator-Activated+Receptor+%28PPAR%29+Induced+Tumors+Including+Hemangiosarcoma&rft.au=ElHage%2C+J+D&rft.aulast=ElHage&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Synephrine and Caffeine on Physiological and Cardiovascular Variables in Female Sprague-Dawley Rats. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39926319; 4146566 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Duffy, P AU - White, G AU - Wall, K AU - Appana, S AU - Pellicore, L AU - Hansen, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Rats KW - Physiology KW - Caffeine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Effects+of+Synephrine+and+Caffeine+on+Physiological+and+Cardiovascular+Variables+in+Female+Sprague-Dawley+Rats.&rft.au=Duffy%2C+P%3BWhite%2C+G%3BWall%2C+K%3BAppana%2C+S%3BPellicore%2C+L%3BHansen%2C+D&rft.aulast=Duffy&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depletion of Mitochondrial DNA in Cardiac and Skeletal Muscle After In Utero Exposure of Mice to Azt and Azt-Containing Combination Anti-Retroviral Therapies T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39923431; 4146317 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Myers, M AU - Von Tungeln, L AU - Beland, F AU - Heflich, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Cardiac muscle KW - Mitochondrial DNA KW - Skeletal muscle KW - Intrauterine exposure KW - Zidovudine KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Depletion+of+Mitochondrial+DNA+in+Cardiac+and+Skeletal+Muscle+After+In+Utero+Exposure+of+Mice+to+Azt+and+Azt-Containing+Combination+Anti-Retroviral+Therapies&rft.au=Myers%2C+M%3BVon+Tungeln%2C+L%3BBeland%2C+F%3BHeflich%2C+R&rft.aulast=Myers&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Safety Thresholds in the Pharmaceutical Development Process for OINDP: A Regulatory Perspective T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39919952; 4144903 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - McGovern, T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39919952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Use+of+Safety+Thresholds+in+the+Pharmaceutical+Development+Process+for+OINDP%3A+A+Regulatory+Perspective&rft.au=McGovern%2C+T&rft.aulast=McGovern&rft.aufirst=T&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression in Primary Hepatocytes Exposed to the Peroxisome Proliferators Activated Receptor-a Agonists T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39919540; 4145542 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Guo, L AU - Fang, H AU - Dial, S AU - Blann, E AU - Collins, J AU - Dragan, Y Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Gene expression KW - Hepatocytes KW - Peroxisomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39919540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Differential+Gene+Expression+in+Primary+Hepatocytes+Exposed+to+the+Peroxisome+Proliferators+Activated+Receptor-a+Agonists&rft.au=Guo%2C+L%3BFang%2C+H%3BDial%2C+S%3BBlann%2C+E%3BCollins%2C+J%3BDragan%2C+Y&rft.aulast=Guo&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profile in Human Skin Fibroblasts Exposed to Potassium Dichromate T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39916870; 4144960 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - He, Q. AU - Joseph, P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Skin KW - Potassium KW - Gene expression KW - Fibroblasts KW - Potassium dichromate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39916870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Gene+Expression+Profile+in+Human+Skin+Fibroblasts+Exposed+to+Potassium+Dichromate&rft.au=He%2C+Q.%3BJoseph%2C+P&rft.aulast=He&rft.aufirst=Q.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concept, History and Application of Safety Thresholds T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39912038; 4144900 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jacobson-Kram, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Historical account UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Concept%2C+History+and+Application+of+Safety+Thresholds&rft.au=Jacobson-Kram%2C+D&rft.aulast=Jacobson-Kram&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a Multidisciplinary Approach That Identified Phenolic Dermal Sensitizers in a Wound Closure Tape T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39911820; 4145639 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Myers, L P AU - Law, B F AU - Fedorowicz, A AU - Sussman, G AU - Siegel, P D AU - Meade, B J AU - Beezhold, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Phenolic compounds KW - Skin KW - Wounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Use+of+a+Multidisciplinary+Approach+That+Identified+Phenolic+Dermal+Sensitizers+in+a+Wound+Closure+Tape&rft.au=Myers%2C+L+P%3BLaw%2C+B+F%3BFedorowicz%2C+A%3BSussman%2C+G%3BSiegel%2C+P+D%3BMeade%2C+B+J%3BBeezhold%2C+D&rft.aulast=Myers&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Food Defense T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39911066; 4146726 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Acheson, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Reviews KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Overview+of+Food+Defense&rft.au=Acheson%2C+D&rft.aulast=Acheson&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Obesity and Increased Susceptibility to Chemically-Induced Neurodegeneration. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910703; 4146347 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - O'Callaghan, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Obesity KW - Neurodegeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Obesity+and+Increased+Susceptibility+to+Chemically-Induced+Neurodegeneration.&rft.au=O%27Callaghan%2C+J&rft.aulast=O%27Callaghan&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical Contaminants in Seafood Integration of Risks and Benefits T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39906783; 4144507 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Bolger, P M AU - Carrington, C D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Seafood KW - Chemical pollution KW - Contaminants KW - Integration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Chemical+Contaminants+in+Seafood+Integration+of+Risks+and+Benefits&rft.au=Bolger%2C+P+M%3BCarrington%2C+C+D&rft.aulast=Bolger&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential Modest Protective Effect of Midazolam on Ketamine-Induced Apoptosis in Rat Forebrain Culture T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39904820; 4145456 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Sadovova, N AU - Zou, X AU - Scallet, A AU - Patterson, T AU - Hanig, J AU - Paule, M AU - Slikker, W AU - Wang, C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Forebrain KW - Apoptosis KW - Midazolam UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39904820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Potential+Modest+Protective+Effect+of+Midazolam+on+Ketamine-Induced+Apoptosis+in+Rat+Forebrain+Culture&rft.au=Sadovova%2C+N%3BZou%2C+X%3BScallet%2C+A%3BPatterson%2C+T%3BHanig%2C+J%3BPaule%2C+M%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Sadovova&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Emergence of (Q)SAR Decision Support Information in FDA Applications T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39904174; 4145313 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Matthews, E J AU - Kruhlak, N L AU - Benz, R AU - Contrera, J F Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Decision support systems KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39904174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Emergence+of+%28Q%29SAR+Decision+Support+Information+in+FDA+Applications&rft.au=Matthews%2C+E+J%3BKruhlak%2C+N+L%3BBenz%2C+R%3BContrera%2C+J+F&rft.aulast=Matthews&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pharmacokinetics of Deet in the Mouse T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901925; 4145929 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - McGuinn, W AU - Peden-Adams, M AU - EuDaly, J AU - Gilkeson, G AU - Keil, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pharmacokinetics KW - DEET UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Pharmacokinetics+of+Deet+in+the+Mouse&rft.au=McGuinn%2C+W%3BPeden-Adams%2C+M%3BEuDaly%2C+J%3BGilkeson%2C+G%3BKeil%2C+D&rft.aulast=McGuinn&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Inflammatory Lung Response in A/J and C57BL/6J Mice Exposed to Stainless Steel Welding Fume T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901082; 4144762 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Zeidler-Erdely, P C AU - Young, S AU - Roberts, J R AU - Reynolds, S H AU - Antonini, J M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lung KW - Welding KW - Steel KW - Fumes KW - Mice KW - Stainless steel KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Inflammatory+Lung+Response+in+A%2FJ+and+C57BL%2F6J+Mice+Exposed+to+Stainless+Steel+Welding+Fume&rft.au=Zeidler-Erdely%2C+P+C%3BYoung%2C+S%3BRoberts%2C+J+R%3BReynolds%2C+S+H%3BAntonini%2C+J+M&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Sandblasted Metal Attenuate or Enhance the Toxicity of Silica Sand? T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901032; 4144749 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Robinson, V AU - Castranova, V AU - Leonard, S AU - Barger, M AU - Pack, D AU - Feather, G AU - Vallyathan, V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Silica KW - Metals KW - Sand UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Does+Sandblasted+Metal+Attenuate+or+Enhance+the+Toxicity+of+Silica+Sand%3F&rft.au=Robinson%2C+V%3BCastranova%2C+V%3BLeonard%2C+S%3BBarger%2C+M%3BPack%2C+D%3BFeather%2C+G%3BVallyathan%2C+V&rft.aulast=Robinson&rft.aufirst=V&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidative Interactions of Single Walled Carbon Nanotubes with RAW 264.7 Macrophages: Role of Iron. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39899588; 4146048 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Shvedova, A A AU - Potapovich, A I AU - Osipov, A N AU - Tyurina, Y Y AU - Kisin, E AU - Schwegler-Berry, D AU - Mercer, R AU - Castranova, V AU - Kagan, V E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Iron KW - Carbon KW - Macrophages KW - Nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Oxidative+Interactions+of+Single+Walled+Carbon+Nanotubes+with+RAW+264.7+Macrophages%3A+Role+of+Iron.&rft.au=Shvedova%2C+A+A%3BPotapovich%2C+A+I%3BOsipov%2C+A+N%3BTyurina%2C+Y+Y%3BKisin%2C+E%3BSchwegler-Berry%2C+D%3BMercer%2C+R%3BCastranova%2C+V%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methods of Manufacture that Remove Contaminants from Fish Oils: Information Compiled Through the GRAS (Generally Recognized as Safe) Notification Program T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39897883; 4144861 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Edwards, A AU - Garcia, E AU - Hendrickson, C AU - Chanderbahn, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Oil KW - Pisces KW - Contaminants KW - Fish oils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Methods+of+Manufacture+that+Remove+Contaminants+from+Fish+Oils%3A+Information+Compiled+Through+the+GRAS+%28Generally+Recognized+as+Safe%29+Notification+Program&rft.au=Edwards%2C+A%3BGarcia%2C+E%3BHendrickson%2C+C%3BChanderbahn%2C+R&rft.aulast=Edwards&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Effect of Stainless Steel Welding Fume Inhalation on Lung Injury, Inflammation, and Defense Responses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39897375; 4144760 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Antonini, J M AU - Stone, S AU - Chen, B AU - Roberts, J R AU - Frazer, A AU - Donlin, M AU - Cumpston, J AU - Frazer, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lung KW - Welding KW - Steel KW - Inhalation KW - Fumes KW - Injuries KW - Stainless steel KW - Inflammation KW - Acute effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Acute+Effect+of+Stainless+Steel+Welding+Fume+Inhalation+on+Lung+Injury%2C+Inflammation%2C+and+Defense+Responses&rft.au=Antonini%2C+J+M%3BStone%2C+S%3BChen%2C+B%3BRoberts%2C+J+R%3BFrazer%2C+A%3BDonlin%2C+M%3BCumpston%2C+J%3BFrazer%2C+D&rft.aulast=Antonini&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In-Situ Perfusion of Rat Mesentery with Drugs to Evaluate Role of Mast Cell Degranualtion in Early Mesenteric Vascular Inflammation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39895658; 4145410 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Knapton, A D AU - Zhang, J AU - Weaver, J L AU - Sistare, F D AU - Hanig, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Drug development KW - Mast cells KW - Perfusion KW - Vascular system KW - Inflammation KW - Mesentery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=In-Situ+Perfusion+of+Rat+Mesentery+with+Drugs+to+Evaluate+Role+of+Mast+Cell+Degranualtion+in+Early+Mesenteric+Vascular+Inflammation&rft.au=Knapton%2C+A+D%3BZhang%2C+J%3BWeaver%2C+J+L%3BSistare%2C+F+D%3BHanig%2C+J&rft.aulast=Knapton&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabonomics of a Rodent Pediatric Nephrotoxicity Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39895373; 4145367 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Schnackenberg, L K AU - Espandiari, P AU - Pine, P S AU - Anderson, R AU - Beger, R D AU - Hanig, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pediatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Metabonomics+of+a+Rodent+Pediatric+Nephrotoxicity+Model&rft.au=Schnackenberg%2C+L+K%3BEspandiari%2C+P%3BPine%2C+P+S%3BAnderson%2C+R%3BBeger%2C+R+D%3BHanig%2C+J&rft.aulast=Schnackenberg&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytochrome C: A Non-Invasive Biomarker of Drug-Induced Liver Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39890980; 4146091 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Miller, T J AU - Espandiari, P AU - Zhang, J AU - Knapton, A AU - Weaver, J L AU - Herman, E H AU - Hanig, J P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Cytochrome c KW - Bioindicators KW - Liver KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39890980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Cytochrome+C%3A+A+Non-Invasive+Biomarker+of+Drug-Induced+Liver+Toxicity&rft.au=Miller%2C+T+J%3BEspandiari%2C+P%3BZhang%2C+J%3BKnapton%2C+A%3BWeaver%2C+J+L%3BHerman%2C+E+H%3BHanig%2C+J+P&rft.aulast=Miller&rft.aufirst=T&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Considerations for Pharmaceutical Products and the Local Lymph Node Assay (LLNA) T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39883559; 4144925 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jacobs, A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Local lymph node assay KW - Pharmaceuticals KW - Lymph UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Considerations+for+Pharmaceutical+Products+and+the+Local+Lymph+Node+Assay+%28LLNA%29&rft.au=Jacobs%2C+A&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of MMA-SS Welding Fumes on the Humoral Immune Response in B6C3F1 Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39882569; 4145496 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Anderson, S E AU - Meade, B J AU - Munson, A E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Welding KW - Fumes KW - Mice KW - Immune response (humoral) KW - Immunity KW - Defense mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Effect+of+MMA-SS+Welding+Fumes+on+the+Humoral+Immune+Response+in+B6C3F1+Mice&rft.au=Anderson%2C+S+E%3BMeade%2C+B+J%3BMunson%2C+A+E&rft.aulast=Anderson&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pre-Exposure to Zymosan Enhances Lung Defense Mechanisms and Accelerates the Pulmonary Clearance of a Bacterial Pathogen in Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39873608; 4144826 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Young, S AU - Roberts, J R AU - Antonini, J M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lung KW - Pathogens KW - Rats KW - Defense mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39873608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Pre-Exposure+to+Zymosan+Enhances+Lung+Defense+Mechanisms+and+Accelerates+the+Pulmonary+Clearance+of+a+Bacterial+Pathogen+in+Rats&rft.au=Young%2C+S%3BRoberts%2C+J+R%3BAntonini%2C+J+M&rft.aulast=Young&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Hazard Assessment for Egg Allergy T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39873173; 4146583 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Assimon, S AU - Bolger, P M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hypersensitivity KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39873173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Health+Hazard+Assessment+for+Egg+Allergy&rft.au=Assimon%2C+S%3BBolger%2C+P+M&rft.aulast=Assimon&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Proinflammatory Role of Mast Cell Degranulation (MCD) in Drug-Induced Vascular Injury in Sprague-Dawley Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39871349; 4145409 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Zhang, J AU - Knapton, A AU - Miller, T J AU - Espandiari, P AU - Anderson, R AU - Herman, E H AU - Snyder, R AU - Hanig, J AU - Weaver, J L Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Injuries KW - Rats KW - Mast cells KW - Vascular system KW - Inflammation KW - Degranulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39871349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Proinflammatory+Role+of+Mast+Cell+Degranulation+%28MCD%29+in+Drug-Induced+Vascular+Injury+in+Sprague-Dawley+Rats&rft.au=Zhang%2C+J%3BKnapton%2C+A%3BMiller%2C+T+J%3BEspandiari%2C+P%3BAnderson%2C+R%3BHerman%2C+E+H%3BSnyder%2C+R%3BHanig%2C+J%3BWeaver%2C+J+L&rft.aulast=Zhang&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fortificants, Nutrients, Medical and Functional Foods: The Alphabet Soup T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870027; 4144919 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Mattia, A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Nutrients KW - Soups KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Fortificants%2C+Nutrients%2C+Medical+and+Functional+Foods%3A+The+Alphabet+Soup&rft.au=Mattia%2C+A&rft.aulast=Mattia&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metal-Induced Oxidative Stress and Cellular Responses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39869957; 4146352 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Shi, X Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Stress KW - Oxidative stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Metal-Induced+Oxidative+Stress+and+Cellular+Responses&rft.au=Shi%2C+X&rft.aulast=Shi&rft.aufirst=X&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Models and Mechanisms of Occupational/Environmental Asthma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39869906; 4146337 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Luster, M I AU - Regal, J F Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Respiratory diseases KW - Asthma KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Models+and+Mechanisms+of+Occupational%2FEnvironmental+Asthma&rft.au=Luster%2C+M+I%3BRegal%2C+J+F&rft.aulast=Luster&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Development of Proteomics-Based Acrylamide Biomarkers Using Surface Enhanced Laser Desorption Ionization (SELDI) T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39869712; 4144360 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Cheever, K L Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Lasers KW - Desorption KW - Ionization KW - Acrylamide KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Development+of+Proteomics-Based+Acrylamide+Biomarkers+Using+Surface+Enhanced+Laser+Desorption+Ionization+%28SELDI%29&rft.au=Cheever%2C+K+L&rft.aulast=Cheever&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kidney Injury Molecule-1 (Kim-1) Expression in Kidney and Urine Following Acute Exposure to Gentamicin and Mercury. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39867928; 4146093 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Goering, P L AU - Vaidya, V S AU - Brown, R P AU - Vakili, Z AU - Rosenzweig, B A AU - Johnson, A M AU - Thompson, K L AU - Bonventre, J V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Kidneys KW - Heavy metals KW - Mercury KW - Injuries KW - Urine KW - Gentamicin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Kidney+Injury+Molecule-1+%28Kim-1%29+Expression+in+Kidney+and+Urine+Following+Acute+Exposure+to+Gentamicin+and+Mercury.&rft.au=Goering%2C+P+L%3BVaidya%2C+V+S%3BBrown%2C+R+P%3BVakili%2C+Z%3BRosenzweig%2C+B+A%3BJohnson%2C+A+M%3BThompson%2C+K+L%3BBonventre%2C+J+V&rft.aulast=Goering&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromium (VI) Induces Antioxidant Gene HO-1 by Activating the CNC Bzip Transcription Factor Nrf2. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39867300; 4146628 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - He, X. AU - Lin, G AU - Zhang, J AU - Ma, Q. Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Chromium KW - Antioxidants KW - Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Chromium+%28VI%29+Induces+Antioxidant+Gene+HO-1+by+Activating+the+CNC+Bzip+Transcription+Factor+Nrf2.&rft.au=He%2C+X.%3BLin%2C+G%3BZhang%2C+J%3BMa%2C+Q.&rft.aulast=He&rft.aufirst=X.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ubiquitination and Degradation of Eukaryotic Translation Initiation Factor 4E Result in Toxicity and Death in HeLa Cells Exposed to Potassium Dichromate T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39867264; 4146626 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Othumpangat, S AU - Joseph, P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Mortality KW - Potassium KW - Translation initiation KW - Potassium dichromate KW - Ubiquitination KW - Translation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Ubiquitination+and+Degradation+of+Eukaryotic+Translation+Initiation+Factor+4E+Result+in+Toxicity+and+Death+in+HeLa+Cells+Exposed+to+Potassium+Dichromate&rft.au=Othumpangat%2C+S%3BJoseph%2C+P&rft.aulast=Othumpangat&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Hemodynamic and Hemolytic Effects of Intravenously Administered Ethylene Glycol in the Pig T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39859116; 4144531 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Brown, R AU - Wray-Cahen, D AU - Lucas, A AU - Steen, A AU - Baskar, H AU - Dux, J AU - Stratmeyer, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hemodynamics KW - Ethylene glycol KW - Ethene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Acute+Hemodynamic+and+Hemolytic+Effects+of+Intravenously+Administered+Ethylene+Glycol+in+the+Pig&rft.au=Brown%2C+R%3BWray-Cahen%2C+D%3BLucas%2C+A%3BSteen%2C+A%3BBaskar%2C+H%3BDux%2C+J%3BStratmeyer%2C+M&rft.aulast=Brown&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Rodent Pediatric Nephrotoxicity Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39856998; 4145455 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Espandiari, P AU - Miller, T AU - Zhang, J AU - Knapton, A AU - Goering, P AU - Brown, R AU - Vaidya, V AU - Johnson, A AU - Bonventre, J AU - Rosenzweig, B AU - Thompson, K AU - Pine, P AU - Schnackenberg, L AU - Beger, R AU - Herman, E AU - Weaver, J AU - Hanig, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pediatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39856998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Characterization+of+a+Rodent+Pediatric+Nephrotoxicity+Model&rft.au=Espandiari%2C+P%3BMiller%2C+T%3BZhang%2C+J%3BKnapton%2C+A%3BGoering%2C+P%3BBrown%2C+R%3BVaidya%2C+V%3BJohnson%2C+A%3BBonventre%2C+J%3BRosenzweig%2C+B%3BThompson%2C+K%3BPine%2C+P%3BSchnackenberg%2C+L%3BBeger%2C+R%3BHerman%2C+E%3BWeaver%2C+J%3BHanig%2C+J&rft.aulast=Espandiari&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolomics Study of Cisplatin-Fed Mice: Role of PPARa T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39856471; 4145373 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Beger, R D AU - Schnackenberg, L AU - Ford, M AU - Megyesi, J AU - Safirstein, R AU - Portilla, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39856471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Metabolomics+Study+of+Cisplatin-Fed+Mice%3A+Role+of+PPARa&rft.au=Beger%2C+R+D%3BSchnackenberg%2C+L%3BFord%2C+M%3BMegyesi%2C+J%3BSafirstein%2C+R%3BPortilla%2C+D&rft.aulast=Beger&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Oxidative Lung Injury and Cellular Responses by Diesel Exhaust Particles in Wild Type and Inducible Nitric Oxide Synthase-Deficient Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39853829; 4145842 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Ma, J Y AU - Barger, M AU - Ma, J K AU - Castranova, V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Particulates KW - Lung KW - Mice KW - Injuries KW - Exhaust emissions KW - Nitric oxide KW - Diesel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39853829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Induction+of+Oxidative+Lung+Injury+and+Cellular+Responses+by+Diesel+Exhaust+Particles+in+Wild+Type+and+Inducible+Nitric+Oxide+Synthase-Deficient+Mice&rft.au=Ma%2C+J+Y%3BBarger%2C+M%3BMa%2C+J+K%3BCastranova%2C+V&rft.aulast=Ma&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Wall Carbon Nanotubes Induce Oxidative Stress, Acute Inflammation, and Progressive Pulmonary Fibrosis T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39851815; 4146047 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kisin, E AU - Murray, A R AU - Castranova, V AU - Kagan, V E AU - Shvedova, A A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Stress KW - Fibrosis KW - Oxidative stress KW - Lung diseases KW - Carbon KW - Inflammation KW - Nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39851815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Single+Wall+Carbon+Nanotubes+Induce+Oxidative+Stress%2C+Acute+Inflammation%2C+and+Progressive+Pulmonary+Fibrosis&rft.au=Kisin%2C+E%3BMurray%2C+A+R%3BCastranova%2C+V%3BKagan%2C+V+E%3BShvedova%2C+A+A&rft.aulast=Kisin&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fiber Size-Specific Exposure Estimates and Updated Mortality Analysis of Chrysotile Asbestos Textile Workers T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39851552; 4145972 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kuempel, E D AU - Stayner, L T AU - Dement, J D AU - Gilbert, S J AU - Hein, M J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Occupational exposure KW - Mortality KW - Fibers KW - Asbestos KW - Textiles KW - Chrysotile UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39851552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Fiber+Size-Specific+Exposure+Estimates+and+Updated+Mortality+Analysis+of+Chrysotile+Asbestos+Textile+Workers&rft.au=Kuempel%2C+E+D%3BStayner%2C+L+T%3BDement%2C+J+D%3BGilbert%2C+S+J%3BHein%2C+M+J&rft.aulast=Kuempel&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of Protein Kinase C in Silica-Induced MAP Kinase and AP-1 Activation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39809783; 4144771 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Ding, M AU - Lu, Y. AU - Bowman, L AU - Castranova, V AU - Vallyathnan, V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - MAP kinase KW - Protein kinase C UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Essential+Role+of+Protein+Kinase+C+in+Silica-Induced+MAP+Kinase+and+AP-1+Activation&rft.au=Ding%2C+M%3BLu%2C+Y.%3BBowman%2C+L%3BCastranova%2C+V%3BVallyathnan%2C+V&rft.aulast=Ding&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Threshold Neurotoxic Exposure to Amphetamine Disrupts Cortical Synaptic Neuroplasticity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39807175; 4144433 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Bowyer, J F AU - Pogge, A R AU - Delongchamp, R R AU - Callaghan, J P O AU - Patel, K M AU - Vrana, K E AU - Freeman, W M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Neurotoxicity KW - Amphetamine KW - Plasticity (synaptic) KW - Plasticity (cortical) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Threshold+Neurotoxic+Exposure+to+Amphetamine+Disrupts+Cortical+Synaptic+Neuroplasticity&rft.au=Bowyer%2C+J+F%3BPogge%2C+A+R%3BDelongchamp%2C+R+R%3BCallaghan%2C+J+P+O%3BPatel%2C+K+M%3BVrana%2C+K+E%3BFreeman%2C+W+M&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship Between Pulmonary Exposure to Multiple Doses of Single Wall Carbon Nanotubes and Atherosclerosis in ApoE-/- Mouse Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39805273; 4146046 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Li, Z J AU - Chapman, R AU - Hulderman, T AU - Salmen, R AU - Shvedova, A AU - Luster, M I AU - Simeonova, P P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Carbon KW - Arteriosclerosis KW - Lung KW - Nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39805273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Relationship+Between+Pulmonary+Exposure+to+Multiple+Doses+of+Single+Wall+Carbon+Nanotubes+and+Atherosclerosis+in+ApoE-%2F-+Mouse+Model&rft.au=Li%2C+Z+J%3BChapman%2C+R%3BHulderman%2C+T%3BSalmen%2C+R%3BShvedova%2C+A%3BLuster%2C+M+I%3BSimeonova%2C+P+P&rft.aulast=Li&rft.aufirst=Z&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Localization of Species-Specific Antibody Binding Sites to Stachybotrys Chartarum Using the Halogen Immunoassay T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39918733; 4146984 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Green, B J AU - Schmechel, D AU - Millecchia, L AU - Blachere, F AU - Beezhold, D Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Immunoassays KW - Halogens KW - Antibodies KW - Stachybotrys chartarum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Localization+of+Species-Specific+Antibody+Binding+Sites+to+Stachybotrys+Chartarum+Using+the+Halogen+Immunoassay&rft.au=Green%2C+B+J%3BSchmechel%2C+D%3BMillecchia%2C+L%3BBlachere%2C+F%3BBeezhold%2C+D&rft.aulast=Green&rft.aufirst=B&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receiver Operating Characteristics (ROC) Analysis of the IMMULITERG-2000 3gAllergy for the Diagnosis of Latex Allergy T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39918588; 4146960 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Biagini, R E AU - MacKenzie, B A AU - Sammons, D L AU - Robertson, S A AU - Krieg Jr, E F AU - Hamilton, R G Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Hypersensitivity KW - Latex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Receiver+Operating+Characteristics+%28ROC%29+Analysis+of+the+IMMULITERG-2000+3gAllergy+for+the+Diagnosis+of+Latex+Allergy&rft.au=Biagini%2C+R+E%3BMacKenzie%2C+B+A%3BSammons%2C+D+L%3BRobertson%2C+S+A%3BKrieg+Jr%2C+E+F%3BHamilton%2C+R+G&rft.aulast=Biagini&rft.aufirst=R&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respiratory Syncytial Virus (rsv) Suppresses CD4 T Cell Proliferation through IFN-Alpha and IFN-Lambda T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39869210; 4146917 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Chi, B AU - Alston, M AU - Rabin, R Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Cell proliferation KW - Lymphocytes T KW - CD4 antigen KW - Respiration KW - Metabolism KW - Respiratory syncytial virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Respiratory+Syncytial+Virus+%28rsv%29+Suppresses+CD4+T+Cell+Proliferation+through+IFN-Alpha+and+IFN-Lambda&rft.au=Chi%2C+B%3BAlston%2C+M%3BRabin%2C+R&rft.aulast=Chi&rft.aufirst=B&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell-Cell Interactions and Cell Fate Determination: Involvement of Dlk in B Cell Developmentand Function T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39807401; 4146825 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Raghunandan, R AU - Rudikoff, E AU - Bauer, S Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Lymphocytes B KW - Cell fate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Cell-Cell+Interactions+and+Cell+Fate+Determination%3A+Involvement+of+Dlk+in+B+Cell+Developmentand+Function&rft.au=Raghunandan%2C+R%3BRudikoff%2C+E%3BBauer%2C+S&rft.aulast=Raghunandan&rft.aufirst=R&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiovascular Disease Mortality Among American Indians and Alaska Natives: A Multiple-Cause Analysis T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40087239; 4157698 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Veazie, Mark A Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - USA, Alaska KW - Mortality KW - Cardiovascular diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40087239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Cardiovascular+Disease+Mortality+Among+American+Indians+and+Alaska+Natives%3A+A+Multiple-Cause+Analysis&rft.au=Veazie%2C+Mark+A&rft.aulast=Veazie&rft.aufirst=Mark&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Translating Epidemiology and Clinical Trial Results into Clinical Care (IHS) T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40080812; 4157371 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Galloway, James M Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Clinical trials KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40080812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Translating+Epidemiology+and+Clinical+Trial+Results+into+Clinical+Care+%28IHS%29&rft.au=Galloway%2C+James+M&rft.aulast=Galloway&rft.aufirst=James&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Morbidity in patients waiting for tonsillectomy in Cardiff: a cross-sectional study. AN - 85385205; pmid-16549039 AB - Our aim was to determine the morbidity of patients awaiting tonsillectomy.The study comprised a questionnaire survey of 379 children and 278 adults waiting over 12 months for tonsillectomy.These comprised frequency of infection, sickness absence and continuing desire for surgery.Response rates were 70 per cent (children) and 60 per cent (adults). Morbidity was similar in adults and children, and in those waiting more or less than two years. In the six months prior to the study, 86 per cent of children and 83 per cent of adults had had tonsillitis. Sixty per cent of children and 50 per cent of adults had had three or more episodes. Sixty-two per cent of children and 59 per cent of adults had had at least one long episode of tonsillitis, and 29 per cent of children and 24 per cent of adults had had more than three long episodes. Eighty-nine per cent of children had missed school at least once, compared with 71 per cent of adults missing work at least once (p = 0.01). The frequency of infection was significantly associated with patients' desire for surgery (p < 0.001).Patients awaiting tonsillectomy experience considerable morbidity. This study does not support the hypothesis that untreated patients will 'outgrow' their condition. JF - The Journal of laryngology and otology AU - Fox, R AU - Tomkinson, A AU - Myers, P AD - National Public Health Service for Wales, Cardiff, Wales, UK. rosemary.fox@nphs.wales.nhs.uk Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 214 EP - 218 VL - 120 IS - 3 SN - 0022-2151, 0022-2151 KW - National Library of Medicine KW - Absenteeism KW - Adult KW - Attitude to Health KW - Child KW - Child Development: physiology KW - Cross-Sectional Studies KW - Family KW - Family Practice KW - Female KW - Humans KW - Male KW - Morbidity KW - Sleep Disorders: complications KW - Sleep Disorders: epidemiology KW - *Tonsillectomy KW - Tonsillitis: complications KW - *Tonsillitis: epidemiology KW - Tonsillitis: physiopathology KW - Wales: epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laryngology+and+otology&rft.atitle=Morbidity+in+patients+waiting+for+tonsillectomy+in+Cardiff%3A+a+cross-sectional+study.&rft.au=Fox%2C+R%3BTomkinson%2C+A%3BMyers%2C+P&rft.aulast=Fox&rft.aufirst=R&rft.date=2006-03-01&rft.volume=120&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laryngology+and+otology&rft.issn=00222151&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Workgroup Report: Indoor Chemistry and Health AN - 743576469; 201004-31-0300329 (CE); 12093646 (EN) AB - Chemicals present in indoor air can react with one another, either in the gas phase or on surfaces, altering the concentrations of both reactants and products. Such chemistry is often the major source of free radicals and other short-lived reactive species in indoor environments. To what extent do the products of indoor chemistry affect human health? To address this question, the National Institute for Occupational Safety and Health sponsored a workshop titled "Indoor Chemistry and Health" on 12-15 July 2004 at the University of California-Santa Cruz. Approximately 70 experts from eight countries participated. Objectives included enhancing communications between researchers in indoor chemistry and health professionals, as well as defining a list of priority research needs related to the topic of the workshop. The ultimate challenges in this emerging field are defining exposures to the products of indoor chemistry and developing an understanding of the links between these exposures and various health outcomes. The workshop was a step toward meeting these challenges. This summary presents the issues discussed at the workshop and the priority research needs identified by the attendees. JF - Environmental Health Perspectives AU - Weschler, Charles J AU - Wells, J R AU - Poppendieck, Dustin AU - Hubbard, Heidi AU - Pearce, Terri A PY - 2006 SP - 442 EP - 446 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Indoor KW - Workshops KW - Priorities KW - Exposure KW - Free radicals KW - Copyrights KW - Human KW - Meetings KW - Indoor environments KW - Gas phases KW - Lists KW - Links KW - Occupational safety KW - Summaries KW - Wells KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743576469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Workgroup+Report%3A+Indoor+Chemistry+and+Health&rft.au=Weschler%2C+Charles+J%3BWells%2C+J+R%3BPoppendieck%2C+Dustin%3BHubbard%2C+Heidi%3BPearce%2C+Terri+A&rft.aulast=Weschler&rft.aufirst=Charles&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure to Environmental Ozone Alters Semen Quality AN - 743574756; 201004-31-0300334 (CE); 12093651 (EN) AB - Idiopathic male infertility may be due to exposure to environmental toxicants that alter spermatogenesis or sperm function. We studied the relationship between air pollutant levels and semen quality over a 2-year period in Los Angeles, California, by analyzing repeated semen samples collected by sperm donors. Semen analysis data derived from 5,134 semen samples from a sperm donor bank were correlated with air pollutant levels (ozone, nitrogen dioxide, carbon monoxide, and particulate matter 10 microm in aerodynamic diameter) measured 0-9, 10-14, and 70-90 days before semen collection dates in Los Angeles between January 1996 and December 1998. A linear mixed-effects model was used to model average sperm concentration and total motile sperm count for the donation from each subject. Changes were analyzed in relationship to biologically relevant time points during spermatogenesis, 0-9, 10-14, and 70-90 days before the day of semen collection. We estimated temperature and seasonality effects after adjusting for a base model, which included donor's date of birth and age at donation. Forty-eight donors from Los Angeles were included as subjects. Donors were included if they collected repeated semen samples over a 12-month period between January 1996 and December 1998. There was a significant negative correlation between ozone levels at 0-9, 10-14, and 70-90 days before donation and average sperm concentration, which was maintained after correction for donor's birth date, age at donation, temperature, and seasonality (p 0.01). No other pollutant measures were significantly associated with sperm quality outcomes. Exposure to ambient ozone levels adversely affects semen quality. JF - Environmental Health Perspectives AU - Sokol, Rebecca Z AU - Kraft, Peter AU - Fowler, Ian M AU - Mamet, Rizvan PY - 2006 SP - 360 EP - 365 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Semen KW - Ozone KW - Pollutants KW - Health KW - Birth KW - Age KW - Spermatogenesis KW - Collection KW - Nitrogen dioxide KW - Correlation KW - Mathematical models KW - Correlation analysis KW - Infertility KW - Males KW - Copyrights KW - Counting KW - Aerodynamics KW - Carbon monoxide KW - Banks KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743574756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Environmental+Ozone+Alters+Semen+Quality&rft.au=Sokol%2C+Rebecca+Z%3BKraft%2C+Peter%3BFowler%2C+Ian+M%3BMamet%2C+Rizvan&rft.aulast=Sokol&rft.aufirst=Rebecca&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Impact of Diet and Betel Nut Use on Skin Lesions Associated with Drinking-Water Arsenic in Pabna, Bangladesh AN - 743508272; 201004-31-0300349 (CE); 12093666 (EN) AB - An established exposure-response relationship exists between water arsenic levels and skin lesions. Results of previous studies with limited historical exposure data, and laboratory animal studies suggest that diet may modify arsenic metabolism and toxicity. In this study, we evaluated the effect of diet on the risk of arsenic-related skin lesions in Pabna, Bangladesh. Six hundred cases and 600 controls loosely matched on age and sex were enrolled at Dhaka Community Hospital, Bangladesh, in 2001-2002. Diet, demographic data, and water samples were collected. Water samples were analyzed for arsenic using inductively coupled plasma mass spectroscopy. Betel nut use was associated with a greater risk of skin lesions in a multivariate model [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.18-2.36]. Modest decreases in risk of skin lesions were associated with fruit intake 1-3 times/month (OR = 0.68; 95%CI, 0.51-0.89) and canned goods at least 1 time/month (OR = 0.41; 95% CI, 0.20-0.86). Bean intake at least 1 time/day (OR = 1.89; 95% CI, 1.11-3.22) was associated with increased odds of skin lesions. Betel nut use appears to be associated with increased risk of developing skin lesions in Bangladesh. Increased intake of fruit and canned goods may be associated with reduced risk of lesions. Increased intake of beans may be associated with an increased risk of skin lesions. The results of this study do not provide clear support for a protective effect of vegetable and overall protein consumption against the development of skin lesions, but a modest benefit cannot be excluded. JF - Environmental Health Perspectives AU - McCarty, Kathleen M AU - Houseman, E Andres AU - Quamruzzaman, Quazi AU - Rahman, Mahmuder PY - 2006 SP - 334 EP - 340 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Lesions KW - Risk KW - Arsenic KW - Diets KW - Intakes KW - Beans KW - Health KW - Fruits KW - Toxicity KW - Drinking water KW - Laboratory animals KW - Protective KW - Mass spectroscopy KW - Hospitals KW - Inductively coupled plasma KW - Confidence intervals KW - Dhaka KW - Vegetables KW - Communities KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743508272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Impact+of+Diet+and+Betel+Nut+Use+on+Skin+Lesions+Associated+with+Drinking-Water+Arsenic+in+Pabna%2C+Bangladesh&rft.au=McCarty%2C+Kathleen+M%3BHouseman%2C+E+Andres%3BQuamruzzaman%2C+Quazi%3BRahman%2C+Mahmuder&rft.aulast=McCarty&rft.aufirst=Kathleen&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Hazards of Genetically Engineered Foods AN - 743504087; 201004-31-0300353 (CE); 12093670 (EN) AB - Correspondence on The Hazards of Genetically Engineered Foods. JF - Environmental Health Perspectives AU - Margulis, Charles PY - 2006 SP - A146 EP - A147 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Foods KW - Hazards KW - Health KW - Genetic engineering KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743504087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Hazards+of+Genetically+Engineered+Foods&rft.au=Margulis%2C+Charles&rft.aulast=Margulis&rft.aufirst=Charles&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A146&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Systemic Microvascular Dysfunction and Inflammation after Pulmonary Particulate Matter Exposure AN - 743498212; 201004-31-0300331 (CE); 12093648 (EN) AB - The epidemiologic association between pulmonary exposure to ambient particulate matter (PM) and cardiovascular dysfunction is well known, but the systemic mechanisms that drive this effect remain unclear. We have previously shown that acute pulmonary exposure to PM impairs or abolishes endothelium-dependent arteriolar dilation in the rat spinotrapezius muscle. The purpose of this study was to further characterize the effect of pulmonary PM exposure on systemic microvascular function and to identify local inflammatory events that may contribute to these effects. Rats were intratracheally instilled with residual oil fly ash (ROFA) or titanium dioxide at 0.1 or 0.25 mg/rat 24 hr before measurement of pulmonary and systemic microvascular responses. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar responses to intraluminal infusion of the Ca2+ ionophore A23187 or iontophoretic abluminal application of the adrenergic agonist phenylephrine (PHE). Leukocyte rolling and adhesion were quantified in venules paired with the studied arterioles. Histologic techniques were used to assess pulmonary inflammation, characterize the adherence of leukocytes to systemic venules, verify the presence of myeloperoxidase (MPO) in the systemic microvascular wall, and quantify systemic microvascular oxidative stress. In the lungs of rats exposed to ROFA or TiO2, changes in some bronchoalveolar lavage markers of inflammation were noted, but an indication of cellular damage was not found. In rats exposed to 0.1 mg ROFA, focal alveolitis was evident, particularly at sites of particle deposition. Exposure to either ROFA or TiO2 caused a dose-dependent impairment of endothelium-dependent arteriolar dilation. However, exposure to these particles did not affect microvascular constriction in response to PHE. ROFA and TiO2 exposure significantly increased leukocyte rolling and adhesion in paired venules, and these cells were positively identified as polymorphonuclear leukocytes (PMNLs). In ROFA- and TiO2-exposed rats, MPO was found in PMNLs adhering to the systemic microvascular wall. Evidence suggests that some of this MPO had been deposited in the microvascular wall. There was also evidence for oxidative stress in the microvascular wall. These results indicate that after PM exposure, the impairment of endothelium-dependent dilation in the systemic microcirculation coincides with PMNL adhesion, MPO deposition, and local oxidative stress. Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure. JF - Environmental Health Perspectives AU - Nurkiewicz, Timothy R AU - Porter, Dale W AU - Barger, Mark AU - Millecchia, Lyndell PY - 2006 SP - 412 EP - 419 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Titanium dioxide KW - Adhesion KW - Leukocytes KW - Rats KW - Dilation KW - Stresses KW - Impairment KW - Deposition KW - Health KW - Muscles KW - Exposure KW - Cellular KW - Particle deposition KW - Indication KW - Fly ash KW - Epidemiology KW - Surgical implants KW - Adrenergics KW - Damage KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743498212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Systemic+Microvascular+Dysfunction+and+Inflammation+after+Pulmonary+Particulate+Matter+Exposure&rft.au=Nurkiewicz%2C+Timothy+R%3BPorter%2C+Dale+W%3BBarger%2C+Mark%3BMillecchia%2C+Lyndell&rft.aulast=Nurkiewicz&rft.aufirst=Timothy&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Assessing Household Solid Fuel Use: Multiple Implications for the Millennium Development Goals AN - 743474080; 201004-31-0300344 (CE); 12093661 (EN) AB - OBJECTIVE: The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our findings in the context of achieving the MDGs. METHODS: For 93 countries, solid fuel use data were compiled from recent national censuses or household surveys. For the 36 countries where no data were available, the indicator was modeled. For 52 upper-middle or high-income countries, the indicator was assumed to be 5%. RESULTS: According to our assessment, 52% of the world's population uses solid fuels. This percentage varies widely between countries and regions, ranging from 77%, 74%, and 74% in Sub-Saharan Africa, Southeast Asia, and the Western Pacific Region, respectively, to 36% in the Eastern Mediterranean Region, 16% in Latin America and the Caribbean and in Central and Eastern Europe. In most industrialized countries, solid fuel use falls to the 5% mark. DISCUSSION: Although the "percentage of population using solid fuels" is classified as an indicator to measure progress towards MDG 7, reliance on traditional household energy practices has distinct implications for most of the MDGs, notably MDGs 4 and 5. There is an urgent need for development agendas to recognize the fundamental role that household energy plays in improving child and maternal health and fostering economic and social development. JF - Environmental Health Perspectives AU - Rehfuess, Eva AU - Mehta, Sumi AU - Pruess-Uestuen, Annette PY - 2006 SP - 373 EP - 378 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Solid fuels KW - Households KW - Health KW - Indicators KW - Ethylene vinyl acetates KW - Assessments KW - Copyrights KW - Economics KW - Energy use KW - Southeast Asia KW - Mathematical models KW - Central America/Caribbean KW - Organizations KW - Surveys KW - Reporting KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743474080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Assessing+Household+Solid+Fuel+Use%3A+Multiple+Implications+for+the+Millennium+Development+Goals&rft.au=Rehfuess%2C+Eva%3BMehta%2C+Sumi%3BPruess-Uestuen%2C+Annette&rft.aulast=Rehfuess&rft.aufirst=Eva&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Separate and Unequal: Residential Segregation and Estimated Cancer Risks Associated with Ambient Air Toxics in U.S. Metropolitan Areas AN - 743466244; 201004-31-0300342 (CE); 12093659 (EN) AB - This study examines links between racial residential segregation and estimated ambient air toxics exposures and their associated cancer risks using modeled concentration estimates from the U.S. Environmental Protection Agency's National Air Toxics Assessment. We combined pollutant concentration estimates with potencies to calculate cancer risks by census tract for 309 metropolitan areas in the United States. This information was combined with socioeconomic status (SES) measures from the 1990 Census. Estimated cancer risks associated with ambient air toxics were highest in tracts located in metropolitan areas that were highly segregated. Disparities between racial/ethnic groups were also wider in more segregated metropolitan areas. Multivariate modeling showed that, after controlling for tract-level SES measures, increasing segregation amplified the cancer risks associated with ambient air toxics for all racial groups combined [highly segregated areas: relative cancer risk (RCR) = 1.04; 95% confidence interval (CI), 1.01-107; extremely segregated areas: RCR = 1.32; 95% CI, 1.28-1.36]. This segregation effect was strongest for Hispanics (highly segregated areas: RCR = 1.09; 95% CI, 1.01-1.17; extremely segregated areas: RCR = 1.74; 95% CI, 1.61-1.88) and weaker among whites (highly segregated areas: RCR = 1.04; 95% CI, 1.01-1.08; extremely segregated areas: RCR = 1.28; 95% CI, 1.24-1.33), African Americans (highly segregated areas: RCR = 1.09; 95% CI, 0.98-1.21; extremely segregated areas: RCR = 1.38; 95% CI, 1.24-1.53), and Asians (highly segregated areas: RCR = 1.10; 95% CI, 0.97-1.24; extremely segregated areas: RCR = 1.32; 95% CI, 1.16-1.51). Results suggest that disparities associated with ambient air toxics are affected by segregation and that these exposures may have health significance for populations across racial lines. JF - Environmental Health Perspectives AU - Morello-Frosch, Rachel AU - Jesdale, Bill M PY - 2006 SP - 386 EP - 393 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Toxic KW - Cancer KW - Toxicology KW - Segregations KW - Metropolitan areas KW - Health KW - Census KW - Estimates KW - Residential KW - Exposure KW - Assessments KW - Amplification KW - Populations KW - Ethnic KW - Links KW - Bills KW - Mathematical models KW - Confidence intervals KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743466244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Separate+and+Unequal%3A+Residential+Segregation+and+Estimated+Cancer+Risks+Associated+with+Ambient+Air+Toxics+in+U.S.+Metropolitan+Areas&rft.au=Morello-Frosch%2C+Rachel%3BJesdale%2C+Bill+M&rft.aulast=Morello-Frosch&rft.aufirst=Rachel&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Using Biologic Markers in Blood to Assess Exposure to Multiple Environmental Chemicals for Inner-City Children 3-6 Years of Age AN - 743457626; 201004-31-0300328 (CE); 12093645 (EN) AB - We assessed concurrent exposure to a mixture of 50 environmental chemicals by measuring the chemicals or their metabolites in the blood of 43 ethnically diverse children (3-6 years of age) from a socioeconomically disadvantaged neighborhood in Minneapolis. Over a 2-year period, additional samples were collected every 6-12 months from as many children as possible. We analyzed blood samples for 11 volatile organic compounds (VOCs), 2 heavy metals (lead and mercury, 11 organochlorine (OC) pesticides or related compounds, and 30 polychlorinated biphenyl (PCB) congeners. The evidence suggests that numerous VOCs originated from common sources, as did many PCBs. Longitudinal measurements indicate that between-child variance was greater than within-child variance for two VOCs (benzene, toluene), for both heavy metals (Pb, Hg), for all detectable OC pesticides, and for 15 of the measured PCB congeners (74, 99, 101, 118, 138-158, 146, 153, 156, 170, 178, 180, 187, 189, 194, 195). Despite the relatively small sample size, highest measured blood levels of 1,4-dichlorobenzene, styrene, m-/p-xylene, Pb, Hg, heptachlor epoxide, oxychlordane, dichlorodiphenyldichloroethene (p,p -DDE), trans-nonachlor, and PCB congeners 74, 99, 105, 118, 138, 146, 153, 156, 170, and 180 were comparable with or higher than 95th percentile measurements of older children and adults from national surveys. Results demonstrate that cumulative exposures to multiple environmental carcinogens and neurotoxins can be comparatively high for children from a poor inner-city neighborhood. JF - Environmental Health Perspectives AU - Sexton, Ken AU - Adgate, John L AU - Fredrickson, Ann L AU - Ryan, Andrew D PY - 2006 SP - 453 EP - 459 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Blood KW - Circuit boards KW - Volatile organic compounds KW - Mercury KW - Congeners KW - Printed circuits KW - Lead (metal) KW - Variance KW - Health KW - Pesticides KW - Heavy metals KW - Age KW - Styrenes KW - Carcinogens KW - Adults KW - Metabolites KW - Markers KW - Surveys KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743457626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Using+Biologic+Markers+in+Blood+to+Assess+Exposure+to+Multiple+Environmental+Chemicals+for+Inner-City+Children+3-6+Years+of+Age&rft.au=Sexton%2C+Ken%3BAdgate%2C+John+L%3BFredrickson%2C+Ann+L%3BRyan%2C+Andrew+D&rft.aulast=Sexton&rft.aufirst=Ken&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Review of Nitrates in Drinking Water: Maternal Exposure and Adverse Reproductive and Developmental Outcomes AN - 743442114; 201004-31-0300348 (CE); 12093665 (EN) AB - In this review we present an update on maternal exposure to nitrates in drinking water in relation to possible adverse reproductive and developmental effects, and also discuss nitrates in drinking water in the United States. The current standard for nitrates in drinking water is based on retrospective studies and approximates a level that protects infants from methemoglobinemia, but no safety factor is built into the standard. The current standard applies only to public water systems. Drinking water source was related to nitrate exposure (i.e., private systems water was more likely than community system water to have nitrate levels above the maximum contaminant limit). Animal studies have found adverse reproductive effects resulting from higher doses of nitrate or nitrite. The epidemiologic evidence of a direct exposure-response relationship between drinking water nitrate level and adverse reproductive effect is still not clear. However, some reports have suggested an association between exposure to nitrates in drinking water and spontaneous abortions, intrauterine growth restriction, and various birth defects. Uncertainties in epidemiologic studies include the lack of individual exposure assessment that would rule out confounding of the exposure with some other cause. Nitrates may be just one of the contaminants in drinking water contributing to adverse outcomes. We conclude that the current literature does not provide sufficient evidence of a causal relationship between exposure to nitrates in drinking water and adverse reproductive effects. Future studies incorporating individual exposure assessment about users of private wells--the population most at risk--should be considered. JF - Environmental Health Perspectives AU - Manassaram, Deana M AU - Backer, Lorraine C AU - Moll, Deborah M PY - 2006 SP - 320 EP - 327 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Drinking water KW - Nitrates KW - Standards KW - Assessments KW - Epidemiology KW - Contaminants KW - Health KW - Infants KW - Spontaneous abortion KW - Safety factors KW - Communities KW - Copyrights KW - Uncertainty KW - Birth defects KW - Constrictions KW - Animals KW - Approximation KW - Exposure KW - Nitrites KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743442114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Review+of+Nitrates+in+Drinking+Water%3A+Maternal+Exposure+and+Adverse+Reproductive+and+Developmental+Outcomes&rft.au=Manassaram%2C+Deana+M%3BBacker%2C+Lorraine+C%3BMoll%2C+Deborah+M&rft.aulast=Manassaram&rft.aufirst=Deana&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prevalence of Arsenic Exposure from Drinking Water and Awareness of Its Health Risks in a Bangladeshi Population: Results from a Large Population-Based Study AN - 743395556; 201004-31-0300350 (CE); 12093667 (EN) AB - We conducted a population-based prevalence survey in Araihazar, Bangladesh, to describe the distribution of arsenic exposure in a rural Bangladeshi population and to assess the population's awareness to this problem as well as to possible remediation options. Water samples from 5,967 contiguous tube wells in a defined geographic area were tested using laboratory-based methods. Additionally, for each well, the owner/caretaker (or a close relative) was interviewed regarding his or her awareness of the health consequences of As exposure. Arsenic exposure data and demographic characteristics for the 65,876 users of these wells were also collected from the 5,967 respondents. Among the 65,876 residents, more than half (54%) regularly consumed well water with an As concentration or = 50 microg/L--above the acceptable government standard in Bangladesh. Respondents were 15-92 years of age, with an average age of 42 years, and 43% were male. Presence of awareness was significantly related to male sex, nonlabor head of household occupation, better housing, and having had the well tested for As concentration. Most respondents (92%) expressed a willingness to take steps to reduce their exposure, with switching to a safe well the most favored option (46.2%). Willingness to reduce exposure was positively related to awareness of the health risks of As. However, the association between awareness and switching to a safe well [odds ratio (OR) = 1.25; 95% confidence interval (CI), 1.01-1.54] was no stronger than the associations between awareness and using surface water (with or without treatments) (OR = 1.54; 95% CI, 1.22-1.95) or using an existing well after treatment or increasing the depth (OR = 1.34; 95% CI, 1.08-1.67). These findings suggest that health education programs may need to target individuals with lower socioeconomic status and that well switching should be encouraged with more appropriate health education. Increasing knowledge of the health consequences of As may be an important element in facilitating remediation. JF - Environmental Health Perspectives AU - Parvez, Faruque AU - Chen, Yu AU - Argos, Maria AU - Hussain, A Z M Iftikhar PY - 2006 SP - 355 EP - 359 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Switching KW - Arsenic KW - Safes KW - Risk KW - Remediation KW - Education KW - Males KW - Wells KW - Age KW - Surface water KW - Drinking water KW - Consumption KW - Occupation KW - Households KW - Tubes KW - Standards KW - Confidence intervals KW - Well waters KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743395556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prevalence+of+Arsenic+Exposure+from+Drinking+Water+and+Awareness+of+Its+Health+Risks+in+a+Bangladeshi+Population%3A+Results+from+a+Large+Population-Based+Study&rft.au=Parvez%2C+Faruque%3BChen%2C+Yu%3BArgos%2C+Maria%3BHussain%2C+A+Z+M+Iftikhar&rft.aulast=Parvez&rft.aufirst=Faruque&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - EPIGENETICS: THE SCIENCE OF CHANGE AN - 743378176; 201004-31-0300352 (CE); 12093669 (EN) AB - The term "epigenetic" refers to any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells. So far, the most compelling evidence linking epigenetic processes with disease has been found for cancer, but many other illnesses also have some level of evidence tying them to epigenetic mechanisms. Investment in epigenetics research has traditionally lagged behind that for traditional genetics research, but new initiatives, including large-scale research projects and a new professional society, are seeking to reverse this. JF - Environmental Health Perspectives AU - Weinhold, Bob AU - Garber, Ken PY - 2006 SP - A160 EP - A167 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Genetics KW - Copyrights KW - Genes KW - Investment KW - Deoxyribonucleic acid KW - Joining KW - Research projects KW - Financing KW - Illnesses KW - Cancer KW - Linking KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743378176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=EPIGENETICS%3A+THE+SCIENCE+OF+CHANGE&rft.au=Weinhold%2C+Bob%3BGarber%2C+Ken&rft.aulast=Weinhold&rft.aufirst=Bob&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A160&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Open House: The Ethics of Studying Children at Home AN - 743377705; 201004-31-0300355 (CE); 12093672 (EN) AB - In September 2005, the National Academies released Ethical Considerations for Research on Housing-Related Health Hazards Involving Children at the request of several federal agencies following the controversial court case Grimes v. Kennedy Krieger Institute. This case called into question the ethical underpinnings of conducting research among low-income populations, particularly with regard to obtaining truly informed consent from the parents of children participating in such studies. The report, which has been received warmly by the research community, makes specific recommendations for researchers and their sponsors and gives clear guidelines for avoiding ethical pitfalls in their work. JF - Environmental Health Perspectives AU - Hood, Ernie PY - 2006 SP - A168 EP - A170 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Ethics KW - Children KW - Health KW - Guidelines KW - Hoods KW - Communities KW - Copyrights KW - Informed consent KW - Health hazards KW - Parents KW - Conduction KW - Populations KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743377705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Open+House%3A+The+Ethics+of+Studying+Children+at+Home&rft.au=Hood%2C+Ernie&rft.aulast=Hood&rft.aufirst=Ernie&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A168&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Policy Implications of Genetic Information on Regulation under the Clean Air Act: The Case of Particulate Matter and Asthmatics AN - 743375906; 201004-31-0300345 (CE); 12093662 (EN) AB - The U.S. Clean Air Act (CAA) explicitly guarantees the protection of sensitive human subpopulations from adverse health effects associated with air pollution exposure. Identified subpopulations, such as asthmatics, may carry multiple genetic susceptibilities to disease onset and progression and thus qualify for special protection under the CAA. Scientific advances accelerated as a result of the groundbreaking Human Genome Project enable the quantification of genetic information that underlies such human variability in susceptibility and the cellular mechanisms of disease. In epidemiology and regulatory toxicology, genetic information can more clearly elucidate human susceptibility essential to risk assessment, such as in support of air quality regulation. In an effort to encourage the incorporation of genomic information in regulation, the U.S. Environmental Protection Agency (EPA) has issued an Interim Policy on Genomics. Additional research strategy and policy documents from the National Academy of Science, the U.S. EPA, and the U.S. Department of Health and Human Services further promote the expansion of asthma genetics research for human health risk assessment. Through a review of these government documents, we find opportunities for the inclusion of genetic information in the regulation of air pollutants. In addition, we identify sources of information in recent scientific research on asthma genetics relevant to regulatory standard setting. We conclude with recommendations on how to integrate these approaches for the improvement of regulatory health science and the prerequisites for inclusion of genetic information in decision making. JF - Environmental Health Perspectives AU - Kramer, C Bradley AU - Cullen, Alison C AU - Faustman, Elaine M PY - 2006 SP - 313 EP - 319 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Genetics KW - Health KW - Human KW - Control KW - Policies KW - Inclusions KW - Asthma KW - Cleaning KW - Risk assessment KW - Genomes KW - Air pollution KW - Cellular KW - Epidemiology KW - Standards KW - Strategy KW - Decision making KW - Copyrights KW - Air quality KW - Progressions KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743375906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Policy+Implications+of+Genetic+Information+on+Regulation+under+the+Clean+Air+Act%3A+The+Case+of+Particulate+Matter+and+Asthmatics&rft.au=Kramer%2C+C+Bradley%3BCullen%2C+Alison+C%3BFaustman%2C+Elaine+M&rft.aulast=Kramer&rft.aufirst=C&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Integrated Assessment of Environment and Health: America's Children and the Environment AN - 743343013; 201004-31-0300336 (CE); 12093653 (EN) AB - The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing the results of such assessments in policy deliberations. As a step in the development of such methods, we used findings and data from the environmental protection and public health sectors to develop a set of measures representing topics relevant to children's environmental health. We used a definition of the environment that emphasized contaminants and a process that involved both analytic and deliberative elements. The steps in this process were to a) develop a conceptual framework to depict relationships between environment and health with relevant types of data and information, b) select topic areas of significance for children, c) identify best available data sources and devise measures, d) assess possible surrogate data sources and measures when needed, e) design and implement metrics for computation of measures using specified data elements, f) select graphical representations of measures, g) identify related measures, and h) identify data gaps. Representatives of policy and stakeholder audiences participated in this process. The measures are presented in three groups that reflect contaminants in the environment, contaminants in human tissues, and diseases and disorders. The measures present scientifically based representations of data understandable to stakeholders and policy makers that integrate key information from the health and environment sectors in a consistent format. JF - Environmental Health Perspectives AU - Kyle, Amy D AU - Woodruff, Tracey J AU - Axelrad, Daniel A PY - 2006 SP - 447 EP - 452 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Policies KW - Assessments KW - Children KW - Contaminants KW - Data sources KW - Graphical representations KW - Diseases KW - Format KW - Disorders KW - Representations KW - Mathematical analysis KW - Human tissues KW - Copyrights KW - Design engineering KW - Public health KW - Computation KW - Gaps KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743343013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Integrated+Assessment+of+Environment+and+Health%3A+America%27s+Children+and+the+Environment&rft.au=Kyle%2C+Amy+D%3BWoodruff%2C+Tracey+J%3BAxelrad%2C+Daniel+A&rft.aulast=Kyle&rft.aufirst=Amy&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice AN - 743339533; 201004-31-0300346 (CE); 12093663 (EN) AB - Increased levels of particulate air pollution are associated with increased respiratory and cardiovascular mortality and morbidity. Some epidemiologic and toxicologic research suggests ultrafine particles (UFPs) ( 100 nm) to be more harmful per unit mass than larger particles. Our study was aimed at a quantitative comparison of acute adverse effects of different types of carbonaceous UFPs at a dose range that causes a moderate inflammatory response in lungs. We used six different particle types (primary particle size 10-50 nm, specific surface area 30-800 m2/g, and organic content 1-20%): PrintexG, Printex90, flame soot particles with different organic content (SootL, SootH), spark-generated ultrafine carbon particles (ufCP), and the reference diesel exhaust particles (DEP) SRM1650a. Mice were instilled with 5, 20, and 50 microg of each particle type, and bronchoalveolar lavage was analyzed 24 hr after instillation for inflammatory cells and the level of proinflammatory cytokines. At respective mass-doses, particle-caused detrimental effects ranked in the following order: ufCP SootL or = SootH Printex90 PrintexG DEP. Relating the inflammatory effects to the particle characteristics--organic content, primary particle size, or specific surface area--demonstrates the most obvious dose response for particle surface area. Our study suggests that the surface area measurement developed by Brunauer, Emmett, and Teller is a valuable reference unit for the assessment of causative health effects for carbonaceous UFPs. Additionally, we demonstrated the existence of a threshold for the particle surface area at an instilled dose of approximately 20 cm2, below which no acute proinflammatory responses could be detected in mice. JF - Environmental Health Perspectives AU - Stoeger, Tobias AU - Reinhard, Claudia AU - Takenaka, Shinji AU - Schroeppel, Andreas PY - 2006 SP - 328 EP - 333 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Surface area KW - Mice KW - Health KW - Ultrafines KW - Specific surface KW - Carbon KW - Thresholds KW - Lungs KW - Air pollution KW - Assessments KW - Soot KW - Cytokines KW - Diesel KW - Inflammatory response KW - Epidemiology KW - Diesel fuels KW - Mortality KW - Copyrights KW - Bronchoalveolar lavage KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743339533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Instillation+of+Six+Different+Ultrafine+Carbon+Particles+Indicates+a+Surface+Area+Threshold+Dose+for+Acute+Lung+Inflammation+in+Mice&rft.au=Stoeger%2C+Tobias%3BReinhard%2C+Claudia%3BTakenaka%2C+Shinji%3BSchroeppel%2C+Andreas&rft.aulast=Stoeger&rft.aufirst=Tobias&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use AN - 743314108; 201004-31-0300335 (CE); 12093652 (EN) AB - This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was for participants to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicologic test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technologic experts, regulators, and the principal validation bodies and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would be a basis for the future validation of the technology when it reaches the appropriate stage. Because of the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas include a) biologic validation of toxicogenomics-based test methods for regulatory decision making, b) technical and bioinformatics aspects related to validation, and c) validation issues as they relate to regulatory acceptance and use of toxicogenomics-based test methods. In this report we summarize the discussions and describe in detail the recommendations for future direction and priorities. JF - Environmental Health Perspectives AU - Corvi, Raffaella AU - Ahr, Hans-Juergen AU - Albertini, Silvio AU - Blakey, David H PY - 2006 SP - 420 EP - 429 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Workshops KW - Health KW - Acceptance tests KW - C (programming language) KW - Bioinformatics KW - Regulators KW - Copyrights KW - Platforms KW - Meetings KW - Acceptance KW - Toxicology KW - Decision making KW - Priorities KW - Covering KW - Complexity KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743314108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Meeting+Report%3A+Validation+of+Toxicogenomics-Based+Test+Systems%3A+ECVAM-ICCVAM%2FNICEATM+Considerations+for+Regulatory+Use&rft.au=Corvi%2C+Raffaella%3BAhr%2C+Hans-Juergen%3BAlbertini%2C+Silvio%3BBlakey%2C+David+H&rft.aulast=Corvi&rft.aufirst=Raffaella&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Meeting Report: Application of Genotyping Methods to Assess Risks from Cryptosporidium in Watersheds AN - 743314042; 201004-31-0300330 (CE); 12093647 (EN) AB - A workshop titled "Application of Genotyping Methods to Assess Pathogen Risks from Cryptosporidium in Drinking Water Catchments" was held at the International Water Association biennial conference, Marrakech, Morocco, 23 September 2004. The workshop presented and discussed the findings of an interlaboratory trial that compared methods for genotyping Cryptosporidium oocysts isolated from feces. The primary goal of the trial and workshop was to assess the utility of current Cryptosporidium genotyping methods for determining the public health significance of oocysts isolated from feces in potable-water-supply watersheds. An expert panel of 16 watershed managers, public health practitioners, and molecular parasitologists was assembled for the workshop. A subordinate goal of the workshop was to educate watershed management and public health practitioners. An open invitation was extended to all conference delegates to attend the workshop, which drew approximately 50 interested delegates. In this report we summarize the peer consensus emerging from the workshop. Recommendations on the use of current methods by watershed managers and public health practitioners were proposed. Importantly, all the methods that were reported in the trial were mutually supporting and found to be valuable and worthy of further utility and development. Where there were choices as to which method to apply, the small-subunit ribosomal RNA gene was considered to be the optimum genetic locus to target. The single-strand conformational polymorphism method was considered potentially the most valuable for discriminating to the subtype level and where a large number of samples were to be analyzed. A research agenda for protozoan geneticists was proposed to improve the utility of methods into the future. Standardization of methods and nomenclature was promoted. JF - Environmental Health Perspectives AU - Ferguson, Christobel AU - Deere, Dan AU - Sinclair, Martha AU - Chalmers, Rachel M PY - 2006 SP - 430 EP - 434 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Workshops KW - Watersheds KW - Public health KW - Cryptosporidium KW - Utilities KW - Risk KW - Health KW - Conferences KW - Feces KW - Panels KW - Interlaboratory KW - Drinking water KW - Ribonucleic acids KW - Standardization KW - International waters KW - Education KW - Genetics KW - Meetings KW - Genes KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743314042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Meeting+Report%3A+Application+of+Genotyping+Methods+to+Assess+Risks+from+Cryptosporidium+in+Watersheds&rft.au=Ferguson%2C+Christobel%3BDeere%2C+Dan%3BSinclair%2C+Martha%3BChalmers%2C+Rachel+M&rft.aulast=Ferguson&rft.aufirst=Christobel&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Methylmercury, Amalgams, and Children's Health/Methylmercury, Amalgams, and Children's Health: Bjoernberg et al. Respond AN - 743310133; 201004-31-0300356 (CE); 12093673 (EN) AB - Correspondence on Methylmercury, Amalgams, and Children's Health, and author's response. JF - Environmental Health Perspectives AU - Guzzi, Gianpaolo AU - Minoia, Claudio AU - Pigatto, Paolo D AU - Severi, Gianluca PY - 2006 SP - A149; author reply A149 EP - 50 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Amalgams KW - Children KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743310133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Methylmercury%2C+Amalgams%2C+and+Children%27s+Health%2FMethylmercury%2C+Amalgams%2C+and+Children%27s+Health%3A+Bjoernberg+et+al.+Respond&rft.au=Guzzi%2C+Gianpaolo%3BMinoia%2C+Claudio%3BPigatto%2C+Paolo+D%3BSeveri%2C+Gianluca&rft.aulast=Guzzi&rft.aufirst=Gianpaolo&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A149%3B+author+reply+A149&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - March 2006 NIEHS News. AN - 743298712; 201004-31-0294801 (CE); 12079345 (EN) AB - Short articles on: Moving On in Vietnam; Beyond the Bench: Tracking Clues with Environmental Health Sleuths; Headliners: Neurobehavioral Deficits in Children from Agricultural Communities. JF - Environmental Health Perspectives AU - L, Claudio AU - T, Tillett AU - J, Phelps PY - 2006 SP - A156 EP - A158 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Tracking KW - Vietnam KW - Communities KW - Copyrights KW - Libraries KW - Benches KW - Medicine KW - Children KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743298712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=March+2006+NIEHS+News.&rft.au=L%2C+Claudio%3BT%2C+Tillett%3BJ%2C+Phelps&rft.aulast=L&rft.aufirst=Claudio&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A156&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - March 2006 forum. AN - 743298366; 201004-31-0294802 (CE); 12079346 (EN) AB - Brief articles on: New Environment Law for Afghanistan; Bowled Over by Dust; The Clear Advantage of Clean Air; Bans, Bans, Good for the Heart!; EHPnet: Wellcome Trust Sanger Institute. JF - Environmental Health Perspectives AU - DA, Taylor AU - V, McGovern AU - T, Lougheed AU - A, Burton AU - EE, Dooley PY - 2006 SP - A152 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Environmental legislation KW - Copyrights KW - Cleaning KW - Law KW - Dust KW - Health KW - Libraries KW - Heart KW - Medicine KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743298366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=March+2006+forum.&rft.au=DA%2C+Taylor%3BV%2C+McGovern%3BT%2C+Lougheed%3BA%2C+Burton%3BEE%2C+Dooley&rft.aulast=DA&rft.aufirst=Taylor&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A152&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Altered Breast Development in Young Girls from an Agricultural Environment AN - 743272963; 201004-31-0300327 (CE); 12093644 (EN) AB - In several human populations, the age at which female breast development begins is reported to have declined over the last five decades. Much debate has occurred over whether this reported decline has actually occurred and what factors contribute to it. However, geographical patterns reflecting earlier developmental onset in some human populations suggest environmental factors influence this phenomenon. These factors include interactions between genetic makeup, nutrition, and possible cumulative exposure to estrogens, both endogenous as well as environmental beginning during in utero development. We examined the onset of breast development in a group of peripubertal girls from the Yaqui Valley of Sonora, Mexico. We observed that girls from valley towns, areas using modern agricultural practices, exhibited larger breast fields than those of girls living in the foothills who exhibited similar stature [e.g., weight, height, body mass index (BMI)], and genetic background. Further, girls from valley towns displayed a poorly defined relationship between breast size and mammary gland development, whereas girls from the Yaqui foothills, where traditional ranching occurs, show a robust positive relationship between breast size and mammary size. The differences noted were obtained by a medically based exam involving morphometric analysis and palpation of tissues, in contrast to visual staging alone. In fact, use of the Tanner scale, involving visual staging of breast development for puberty, detected no differences between the study populations. Mammary tissue, determined by palpation, was absent in 18.5% of the girls living in agricultural areas, although palpable breast adipose tissue was present. No relationship was seen between mammary diameter and weight or BMI in either population. These data suggest that future in-depth studies examining mammary tissue growth and fat deposition in breast tissue are required if we are to understand environmental influences on these phenomena. JF - Environmental Health Perspectives AU - Guillette, Elizabeth A AU - Conard, Craig AU - Lares, Fernando AU - Aguilar, Maria Guadalupe PY - 2006 SP - 471 EP - 475 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Breast KW - Girls KW - Populations KW - Valleys KW - Foothills KW - Towns KW - Genetics KW - Bismaleimides KW - Health KW - Visual KW - Human KW - Mammary glands KW - Nutrition KW - Estrogens KW - Deposition KW - Agricultural practices KW - Agronomy KW - Copyrights KW - Females KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743272963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Altered+Breast+Development+in+Young+Girls+from+an+Agricultural+Environment&rft.au=Guillette%2C+Elizabeth+A%3BConard%2C+Craig%3BLares%2C+Fernando%3BAguilar%2C+Maria+Guadalupe&rft.aulast=Guillette&rft.aufirst=Elizabeth&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats AN - 743220370; 201004-31-0300338 (CE); 12093655 (EN) AB - The Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation has conducted a long-term bioassay on aspartame (APM), a widely used artificial sweetener. APM was administered with feed to 8-week-old Sprague-Dawley rats (100-150/sex/group), at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. The treatment lasted until natural death, at which time all deceased animals underwent complete necropsy. Histopathologic evaluation of all pathologic lesions and of all organs and tissues collected was routinely performed on each animal of all experimental groups. The results of the study show for the first time that APM, in our experimental conditions, causes a) an increased incidence of malignant-tumor-bearing animals with a positive significant trend in males (p or = 0.05) and in females (p or = 0.01), in particular those females treated at 50,000 ppm (p or = 0.01); b) an increase in lymphomas and leukemias with a positive significant trend in both males (p or = 0.05) and females (p or = 0.01), in particular in females treated at doses of 100,000 (p or = 0.01), 50,000 (p or = 0.01), 10,000 (p or = 0.05), 2,000 (p or = 0.05), or 400 ppm (p or = 0.01); c) a statistically significant increased incidence, with a positive significant trend (p or = 0.01), of transitional cell carcinomas of the renal pelvis and ureter and their precursors (dysplasias) in females treated at 100,000 (p or = 0.01), 50,000 (p or = 0.01), 10,000 (p or = 0.01), 2,000 (p or = 0.05), or 400 ppm (p or = 0.05); and d) an increased incidence of malignant schwannomas of peripheral nerves with a positive trend (p or = 0.05) in males. The results of this mega-experiment indicate that APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake. On the basis of these results, a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed. JF - Environmental Health Perspectives AU - Soffritti, Morando AU - Belpoggi, Fiorella AU - Esposti, Davide Degli AU - Lambertini, Luca PY - 2006 SP - 379 EP - 385 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Females KW - Trends KW - Incidence KW - Males KW - Animals KW - Aspartame KW - Carcinogens KW - Health KW - Rats KW - Peripheral nerves KW - Guidelines KW - Leukemias KW - Sweeteners KW - Bioassay KW - Foundations KW - Cancer KW - Pelvis KW - Copyrights KW - Precursors KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743220370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=First+Experimental+Demonstration+of+the+Multipotential+Carcinogenic+Effects+of+Aspartame+Administered+in+the+Feed+to+Sprague-Dawley+Rats&rft.au=Soffritti%2C+Morando%3BBelpoggi%2C+Fiorella%3BEsposti%2C+Davide+Degli%3BLambertini%2C+Luca&rft.aulast=Soffritti&rft.aufirst=Morando&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Global Gene Expression Associated with Hepatocarcinogenesis in Adult Male Mice Induced by in Utero Arsenic Exposure AN - 743214356; 201004-31-0300343 (CE); 12093660 (EN) AB - Our previous work has shown that exposure to inorganic arsenic in utero produces hepatocellular carcinoma (HCC) in adult male mice. To explore further the molecular mechanisms of transplacental arsenic hepatocarcinogenesis, we conducted a second arsenic transplacental carcinogenesis study and used a genomewide microarray to profile arsenic-induced aberrant gene expression more extensively. Briefly, pregnant C3H mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from days 8 to 18 of gestation. The incidence of HCC in adult male offspring was increased 4-fold and tumor multiplicity 3-fold after transplacental arsenic exposure. Samples of normal liver and liver tumors were taken at autopsy for genomic analysis. Arsenic exposure in utero resulted in significant alterations (p 0.001) in the expression of 2,010 genes in arsenic-exposed liver samples and in the expression of 2,540 genes in arsenic-induced HCC. Ingenuity Pathway Analysis revealed that significant alterations in gene expression occurred in a number of biological networks, and Myc plays a critical role in one of the primary networks. Real-time reverse transcriptase-polymerase chain reaction and Western blot analysis of selected genes/proteins showed 90% concordance. Arsenic-altered gene expression included activation of oncogenes and HCC biomarkers, and increased expression of cell proliferation-related genes, stress proteins, and insulin-like growth factors and genes involved in cell-cell communications. Liver feminization was evidenced by increased expression of estrogen-linked genes and altered expression of genes that encode gender-related metabolic enzymes. These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis. JF - Environmental Health Perspectives AU - Liu, Jie AU - Xie, Yaxiong AU - Ducharme, Danica M K AU - Shen, Jun PY - 2006 SP - 404 EP - 411 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Genes KW - Gene expression KW - Liver KW - Mice KW - Adults KW - Males KW - Gestation KW - Drinking water KW - Networks KW - Tumors KW - Health KW - Alterations KW - Enzymes KW - Activation KW - Sodium arsenite KW - Autopsies KW - Carcinogens KW - Chain reactions KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743214356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Gene+Expression+Associated+with+Hepatocarcinogenesis+in+Adult+Male+Mice+Induced+by+in+Utero+Arsenic+Exposure&rft.au=Liu%2C+Jie%3BXie%2C+Yaxiong%3BDucharme%2C+Danica+M+K%3BShen%2C+Jun&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - From Resource Scarcity to Ecological Security: Exploring New Limits to Growth AN - 743209722; 201004-31-0300326 (CE); 12093643 (EN) AB - In the face of declining resource availability coupled with increasing consumer demand, the publication of From Resource Scarcity to Ecological Security: Exploring New Limits to Growth is a welcome addition to the literature. Over 30 years have passed since the MIT Press published the groundbreaking The Limits of Growth, and this new book reminds us of the urgent need to manage our unprecedented growth--and our often unreasonable demands. JF - Environmental Health Perspectives AU - Cook, Angus PY - 2006 SP - a190 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Computer information security KW - Marketing KW - Health KW - Ecology KW - Demand KW - Books KW - Copyrights KW - Availability KW - Presses KW - Heating KW - Documents KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743209722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=From+Resource+Scarcity+to+Ecological+Security%3A+Exploring+New+Limits+to+Growth&rft.au=Cook%2C+Angus&rft.aulast=Cook&rft.aufirst=Angus&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=a190&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Distinct Gene Expression Profiles in Immortalized Human Urothelial Cells Exposed to Inorganic Arsenite and Its Methylated Trivalent Metabolites AN - 743183352; 201004-31-0300333 (CE); 12093650 (EN) AB - Inorganic arsenic is an environmental carcinogen. The generation of toxic trivalent methylated metabolites complicates the study of arsenic-mediated carcinogenesis. This study systematically evaluated the effect of chronic treatment with sodium arsenite (iAs(III)), monomethylarsonous acid (MMA(III)), and dimethylarsinous acid (DMA(III)) on immortalized human uroepithelial cells (SV-HUC-1 cells) using cDNA microarray. After exposure for 25 passages to iAs(III) (0.5 microM), MMA(III) (0.05, 0.1, or 0.2 microM), or DMA(III) (0.2 or 0.5 microM), significant compound-specific morphologic changes were observed. A set of 114 genes (5.7% of the examined genes) was differentially expressed in one or more sets of arsenical-treated cells compared with untreated controls. Expression analysis showed that exposure of cells to DMA(III) resulted in a gene profile different from that in cells exposed to iAs(III) or MMA(III), and that the iAs(III)-induced gene profile was closest to that in the tumorigenic HUC-1-derived 3-methylcholanthrene-induced tumorigenic cell line MC-SV-HUC T2, which was derived from SV-HUC-1 cells by methylcholanthrene treatment. Of the genes affected by all three arsenicals, only one, that coding for interleukin-1 receptor, type II, showed enhanced expression, a finding confirmed by the reduced increase in NF-kappaB (nuclear factor kappa B) activity seen in response to interleukin-1beta in iAs(III)-exposed cells. The expression of 11 genes was suppressed by all three arsenicals. 5-Aza-deoxycytidine partially restored the transcription of several suppressed genes, showing that epigenetic DNA methylation was probably involved in arsenical-induced gene repression. Our data demonstrate that chronic exposure to iAs(III), MMA(III), or DMA(III) has different epigenetic effects on urothelial cells and represses NF-kappaB activity. JF - Environmental Health Perspectives AU - Su, Pei-Fen AU - Hu, Yu-Jie AU - Ho, I-Ching AU - Cheng, Yang-Ming AU - Lee, Te-Chang PY - 2006 SP - 394 EP - 403 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Genes KW - Arsenic KW - Carcinogens KW - Health KW - Human KW - Exposure KW - Sodium arsenite KW - Gene expression KW - Methylation KW - Coding KW - Metabolites KW - Toxic KW - Receptors KW - Control equipment KW - Copyrights KW - Deoxyribonucleic acid KW - Methylated metabolites KW - Toxicology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743183352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Distinct+Gene+Expression+Profiles+in+Immortalized+Human+Urothelial+Cells+Exposed+to+Inorganic+Arsenite+and+Its+Methylated+Trivalent+Metabolites&rft.au=Su%2C+Pei-Fen%3BHu%2C+Yu-Jie%3BHo%2C+I-Ching%3BCheng%2C+Yang-Ming%3BLee%2C+Te-Chang&rft.aulast=Su&rft.aufirst=Pei-Fen&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Credibility of Scientists: Industry versus Public Interest AN - 743153565; 201004-31-0300354 (CE); 12093671 (EN) AB - Correspondence on Credibility of Scientists: Industry versus Public Interest; Credibility of Scientists: Conflict of Interest and Bias; and author response. JF - Environmental Health Perspectives AU - Goozner, Merrill PY - 2006 SP - A147; author reply A148 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Scientists KW - Health KW - Copyrights KW - Bias KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743153565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Credibility+of+Scientists%3A+Industry+versus+Public+Interest&rft.au=Goozner%2C+Merrill&rft.aulast=Goozner&rft.aufirst=Merrill&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A147%3B+author+reply+A148&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Correlation of in Vitro Cytokine Responses with the Chemical Composition of Soil-Derived Particulate Matter AN - 743149147; 201004-31-0300351 (CE); 12093668 (EN) AB - We treated human lung epithelial cells, type BEAS-2B, with 10-80 microg/cm2 of dust from soils and road surfaces in the western United States that contained particulate matter (PM) 2.5 microm aerodynamic diameter. Cell viability and cytokine secretion responses were measured at 24 hr. Each dust sample is a complex mixture containing particles from different minerals mixed with biogenic and anthropogenic materials. We determined the particle chemical composition using methods based on the U.S. Environmental Protection Agency Speciation Trends Network (STN) and the National Park Service Interagency Monitoring of Protected Visual Environments (IMPROVE) network. The functionally defined carbon fractions reported by the ambient monitoring networks have not been widely used for toxicology studies. The soil-derived PM2.5 from different sites showed a wide range of potency for inducing the release of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in vitro. Univariate regression and multivariate redundancy analysis were used to test for correlation of viability and cytokine release with the concentrations of 40 elements, 7 ions, and 8 carbon fractions. The particles showed positive correlation between IL-6 release and the elemental and pyrolyzable carbon fractions, and the strongest correlation involving crustal elements was between IL-6 release and the aluminum:silicon ratio. The observed correlations between low-volatility organic components of soil- and road-derived dusts and the cytokine release by BEAS-2B cells are relevant for investigation of mechanisms linking specific air pollution particle types with the initiating events leading to airway inflammation in sensitive populations. JF - Environmental Health Perspectives AU - Veranth, John M AU - Moss, Tyler A AU - Chow, Judith C AU - Labban, Raed PY - 2006 SP - 341 EP - 349 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cytokines KW - Correlation KW - Carbon KW - Networks KW - Dust KW - In vitro testing KW - Viability KW - Health KW - Monitoring KW - Chemical composition KW - Air pollution KW - Secretions KW - Redundancy KW - Soils KW - Regression KW - Populations KW - Regression analysis KW - Roads KW - Speciation KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743149147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Correlation+of+in+Vitro+Cytokine+Responses+with+the+Chemical+Composition+of+Soil-Derived+Particulate+Matter&rft.au=Veranth%2C+John+M%3BMoss%2C+Tyler+A%3BChow%2C+Judith+C%3BLabban%2C+Raed&rft.aulast=Veranth&rft.aufirst=John&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Considering a Society of Environmental Health Science AN - 743141283; 201004-31-0300357 (CE); 12093674 (EN) AB - Although it may seem counterintuitive, the more we learn about science, the more complex it becomes. This is particularly true in the field of environmental health science. As the field has evolved, we've come to realize that the environment permeates nearly every question of human disease and that various forms of environmental stress can be used to understand many of the secrets of human biology. And the challenges that lie before us in solving the mysteries of these relationships will require the combined knowledge of a diverse array of scientific thinkers. For this and other reasons, the time is ripe for the field of environmental health science to consider the benefits of establishing a broad, vigorous, engaged scientific society. JF - Environmental Health Perspectives AU - Schwartz, David A PY - 2006 SP - A142 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Human KW - Copyrights KW - Arrays KW - Stresses KW - Biology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743141283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Considering+a+Society+of+Environmental+Health+Science&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A142&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Cell Scenario: A New Look at Microarrays AN - 743123494; 201004-31-0300347 (CE); 12093664 (EN) AB - The Phenotype MicroArraytrade mark (PM) is a new tool offering a panoramic view of how cells behave when exposed to environmental agents. Just like a battery of tests on a person's blood can scan the health of vital organs, the PM can scan the physiology of cells, yielding data on up to 2,000 traits--or phenotypes--under hundreds of growth conditions. The PM can be used for a number of research, biomanufacturing, and pharmaceutical applications, and the recent introduction of a mammalian version of the PM may allow greater insight into how organisms react to environmental agents. JF - Environmental Health Perspectives AU - Potera, Carol PY - 2006 SP - A172 EP - A175 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Battery KW - Copyrights KW - Blood KW - Tools KW - Organisms KW - Organs KW - Electric batteries KW - Exposure KW - Pharmaceuticals KW - Physiology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743123494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cell+Scenario%3A+A+New+Look+at+Microarrays&rft.au=Potera%2C+Carol&rft.aulast=Potera&rft.aufirst=Carol&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=A172&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Chromium on the Hands of Children After Playing in Playgrounds Built from Chromated Copper Arsenate (CCA)-Treated Wood AN - 743119127; 201004-31-0300337 (CE); 12093654 (EN) AB - Children's exposure to arsenic and chromium from playground equipment constructed with chromated copper arsenate (CCA)-treated wood is a potential concern because of children's hand-to-mouth activity. However, there exists no direct measure of Cr levels on the hands of children after playing in such playgrounds. In this study we measured both soluble and total Cr on the hands of 139 children playing in playgrounds, eight of which were constructed with CCA-treated wood and eight of which were not. Children's age and duration of play were recorded. The hands of each child were washed after play with 150 mL deionized water, which was collected in a bag and subsequently underwent analysis of Cr and 20 other elements, using inductively coupled plasma mass spectrometry. Total average Cr on the hands of 63 children who played in CCA playgrounds was 1,112 +/- 1,089 ng (median, 688; range 78-5,875). Total average Cr on the hands of 64 children who played in non-CCA playgrounds was 652 +/- 586 ng (median, 492; range 61-3,377). The difference between the two groups is statistically significant (p 0.01). Cr levels were highly correlated to both Cu (r = 0.672) and As (r = 0.736) levels in CCA playgrounds (p or = 0.01), but not non-CCA playgrounds (r = 0.252 and 0.486 for Cu and As, respectively). Principal-component analysis indicates that Cr, Cu, and As are more closely grouped together in CCA than in non-CCA playgrounds. These results suggest that the elevated levels of Cr and As on children's hands are due to direct contact with CCA wood. JF - Environmental Health Perspectives AU - Hamula, Camille AU - Wang, Zhongwen AU - Zhang, Hongquan AU - Kwon, Elena PY - 2006 SP - 460 EP - 465 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Chromium KW - Children KW - Playgrounds KW - Wood KW - Copper KW - Copper arsenate KW - Chromates KW - Health KW - Correlation KW - Construction equipment KW - Contact KW - Mass spectrometry KW - Inductively coupled plasma KW - Elevated KW - Deionization KW - Construction KW - Copyrights KW - Arsenic KW - Age KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743119127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Chromium+on+the+Hands+of+Children+After+Playing+in+Playgrounds+Built+from+Chromated+Copper+Arsenate+%28CCA%29-Treated+Wood&rft.au=Hamula%2C+Camille%3BWang%2C+Zhongwen%3BZhang%2C+Hongquan%3BKwon%2C+Elena&rft.aulast=Hamula&rft.aufirst=Camille&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Childhood Correlates of Blood Lead Levels in Mumbai and Delhi AN - 743115953; 201004-31-0300332 (CE); 12093649 (EN) AB - BACKGROUND: Lead exposure has previously been associated with intellectual impairment in children in a number of international studies. In India, it has been reported that nearly half of the children have elevated blood lead levels (BLLs). However, little is known about risk factors for these elevated BLLs. METHODS: We conducted a retrospective cross-sectional analysis of data from the Indian National Family Health Survey, a population-based study conducted in 1998-1999. We assessed potential correlates of BLLs in 1,081 children who were 3 years of age and living in Mumbai or Delhi, India. We examined factors such as age, sex, religion, caste, mother's education, standard of living, breast-feeding, and weight/height percentile. RESULTS: Most children (76%) had BLLs between 5 and 20 microg/dL. Age, standard of living, weight/height percentile, and total number of children ever born to the mother were significantly associated with BLLs (log transformed) in multivariate regression models. Compared with children or = 3 months of age, children 4-11 and 12-23 month of age had 84 and 146% higher BLLs, respectively (p 0.001). A low standard of living correlated with a 32.3% increase in BLLs (p = 0.02). Children greater than the 95th percentile for their weight/height had 31% (p = 0.03) higher BLLs compared with those who were below the 5th percentile for their weight/height. CONCLUSIONS: Our study found various factors correlated with elevated BLLs in children. The correlation between greater than the 95th percentile weight/height and higher BLL may reflect an impact of lead exposure on body habitus. Our study may help in targeting susceptible populations and identifying correctable factors for elevated BLLs in Mumbai and Delhi. JF - Environmental Health Perspectives AU - Jain, Nitin B AU - Hu, Howard PY - 2006 SP - 466 EP - 470 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Mathematical models KW - Age KW - Correlation KW - Elevated KW - Standards KW - Health KW - Mumbai KW - Blood KW - Regression KW - Risk KW - Impairment KW - Indian KW - Populations KW - Religion KW - Education KW - Correlation analysis KW - Copyrights KW - Sex KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Childhood+Correlates+of+Blood+Lead+Levels+in+Mumbai+and+Delhi&rft.au=Jain%2C+Nitin+B%3BHu%2C+Howard&rft.aulast=Jain&rft.aufirst=Nitin&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Human-Health Risk Assessment for West Nile Virus and Insecticides Used in Mosquito Management AN - 743082708; 201004-31-0300340 (CE); 12093657 (EN) AB - West Nile virus (WNV) has been a major public health concern in North America since 1999, when the first outbreak in the Western Hemisphere occurred in New York City. As a result of this ongoing disease outbreak, management of mosquitoes that vector WNV throughout the United States and Canada has necessitated using insecticides in areas where they traditionally have not been used or have been used less frequently. This has resulted in concerns by the public about the risks from insecticide use. The objective of this study was to use reasonable worst-case risk assessment methodologies to evaluate human-health risks for WNV and the insecticides most commonly used to control adult mosquitoes. We evaluated documented health effects from WNV infection and determined potential population risks based on reported frequencies. We determined potential acute (1-day) and subchronic (90-day) multiroute residential exposures from each insecticide for several human subgroups during a WNV disease outbreak scenario. We then compared potential insecticide exposures to toxicologic and regulatory effect levels. Risk quotients (RQs, the ratio of exposure to toxicologic effect) were 1.0 for all subgroups. Acute RQs ranged from 0.0004 to 0.4726, and subchronic RQs ranged from 0.00014 to 0.2074. Results from our risk assessment and the current weight of scientific evidence indicate that human-health risks from residential exposure to mosquito insecticides are low and are not likely to exceed levels of concern. Further, our results indicate that, based on human-health criteria, the risks from WNV exceed the risks from exposure to mosquito insecticides. JF - Environmental Health Perspectives AU - Peterson, Robert K D AU - Macedo, Paula A AU - Davis, Ryan S PY - 2006 SP - 366 EP - 372 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Insecticides KW - Risk KW - Exposure KW - Health KW - Risk assessment KW - Outbreaks KW - Mosquitoes KW - Management KW - Subgroups KW - Residential KW - Disease control KW - Adults KW - Criteria KW - Mathematical analysis KW - Vectors (mathematics) KW - Americas KW - Copyrights KW - Quotients KW - Public health KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743082708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Human-Health+Risk+Assessment+for+West+Nile+Virus+and+Insecticides+Used+in+Mosquito+Management&rft.au=Peterson%2C+Robert+K+D%3BMacedo%2C+Paula+A%3BDavis%2C+Ryan+S&rft.aulast=Peterson&rft.aufirst=Robert+K&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Graded Associations of Blood Lead and Urinary Cadmium Concentrations with Oxidative-Stress-Related Markers in the U.S. Population: Results from the Third National Health and Nutrition Examination Survey AN - 743070606; 201004-31-0300341 (CE); 12093658 (EN) AB - Although oxidative stress has been proposed as a mechanism of lead and cadmium toxicity mostly based on in vitro experiments or animal studies, it is uncertain whether this mechanism is relevant in the pathogenesis of lead- or cadmium-related diseases in the general population with low environmental exposure to lead and cadmium. We examined associations of blood lead and urinary cadmium levels with oxidative stress markers of serum gamma-glutamyltransferase (GGT), vitamin C, carotenoids, and vitamin E among 10,098 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjusting for race, sex, and age (plus serum total cholesterol in the case of serum carotenoids and vitamin E), blood lead and urinary cadmium levels both showed graded associations, positive with serum GGT and inverse with serum vitamin C, carotenoids, and vitamin E (p for trend 0.01, respectively). These associations were consistently observed among most subgroups: non-Hispanic white, non-Hispanic black, men, women, all age groups, nondrinkers, drinkers, nonsmokers, ex-smokers, current smokers, and body mass index ( 25, 25-29.9, and or = 30). The strong association of blood lead and urinary cadmium levels with oxidative stress markers in this population suggests that oxidative stress should be considered in the pathogenesis of lead- and cadmium-related diseases even among people with low environmental exposure to lead and cadmium. JF - Environmental Health Perspectives AU - Lee, Duk-Hee AU - Lim, Ji-Sun AU - Song, Kyungeun AU - Boo, Yongchool AU - Jacobs, David R, Jr PY - 2006 SP - 350 EP - 354 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cadmium KW - Serums KW - Health KW - Blood KW - Stresses KW - Vitamin E KW - Markers KW - Carotenoids KW - Nutrition KW - Diseases KW - Vitamin C KW - Pathogenesis KW - Age KW - Toxicity KW - Adults KW - In vitro testing KW - Race KW - Stress concentration KW - Men KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743070606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Graded+Associations+of+Blood+Lead+and+Urinary+Cadmium+Concentrations+with+Oxidative-Stress-Related+Markers+in+the+U.S.+Population%3A+Results+from+the+Third+National+Health+and+Nutrition+Examination+Survey&rft.au=Lee%2C+Duk-Hee%3BLim%2C+Ji-Sun%3BSong%2C+Kyungeun%3BBoo%2C+Yongchool%3BJacobs%2C+David+R%2C+Jr&rft.aulast=Lee&rft.aufirst=Duk-Hee&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Airborne hexamethylene diisocyanate and particulate matter exposures during fire/rescue vehicle ladder finishing operations. AN - 70701381; 16423809 JF - Journal of occupational and environmental hygiene AU - Mazzuckelli, Lawrence F AU - Methner, Mark M AU - Achutan, Chandran AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - D28 EP - D32 VL - 3 IS - 3 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Cyanates KW - Dust KW - Isocyanates KW - 1,6-hexamethylene diisocyanate KW - 0I70A3I1UF KW - Steel KW - 12597-69-2 KW - Quartz KW - 14808-60-7 KW - Index Medicus KW - United States KW - Respiratory Protective Devices KW - Ventilation KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Motor Vehicles KW - Environmental Monitoring KW - Threshold Limit Values KW - Protective Clothing KW - Manufactured Materials KW - Quartz -- analysis KW - Cyanates -- standards KW - Occupational Exposure -- prevention & control KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Paint KW - Air Pollutants, Occupational -- standards KW - Cyanates -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70701381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Airborne+hexamethylene+diisocyanate+and+particulate+matter+exposures+during+fire%2Frescue+vehicle+ladder+finishing+operations.&rft.au=Mazzuckelli%2C+Lawrence+F%3BMethner%2C+Mark+M%3BAchutan%2C+Chandran&rft.aulast=Mazzuckelli&rft.aufirst=Lawrence&rft.date=2006-03-01&rft.volume=3&rft.issue=3&rft.spage=D28&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Framework for considering genetics in the workplace. AN - 68921115; 17017368 AB - There has been aproliferation of genetic information in the last 25 years resulting in a spectrum of existing and potential uses in the workplace. These uses of have different issues and implications which may be more clearly considered in a framework that identifies three distinct uses (research, practice, and regulation/litigation) for inherited genetic factors and acquired genetic effects. Inherited genetic factors pertain to the characteristics of the genes, and acquired genetic effects to the impact on genes and chromosomes of environmental and constitutional factors. Critical in assessing the issues involving genetics in the workplace is attention on the rights of workers, validity and clinical utility of genetic information, cost pressures on employers, and societal implications. Genetic information may provide mechanistic and diagnostic insight into occupational diseases and allow for targeting high-risk groups, improving risk assessments, and providing early indicators of risk. However, these benefits are more likely to be realized and problems avoided when the different uses are considered in a framework that distinguishes them by type and content. The application of such a framework makes it easier to assess whether there is a sufficient evidence base and worker safeguards in place for any particular use of genetic information. JF - La Medicina del lavoro AU - Schulte, P A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. PSchulte@cdc.gov PY - 2006 SP - 339 EP - 347 VL - 97 IS - 2 SN - 0025-7818, 0025-7818 KW - Index Medicus KW - Occupational Diseases -- diagnosis KW - Humans KW - Occupational Diseases -- prevention & control KW - Genetic Testing -- ethics KW - Workers' Compensation KW - Human Experimentation -- ethics KW - Genetic Testing -- legislation & jurisprudence KW - Risk KW - Gene Expression Profiling KW - Environmental Monitoring -- ethics KW - Mutagenicity Tests KW - Occupational Diseases -- genetics KW - Work Capacity Evaluation KW - Workplace -- legislation & jurisprudence KW - Risk Management KW - Genetic Predisposition to Disease KW - Human Rights KW - Environmental Monitoring -- methods KW - Occupational Medicine -- ethics KW - Occupational Medicine -- legislation & jurisprudence KW - Genetics, Medical -- methods KW - Occupational Medicine -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68921115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=La+Medicina+del+lavoro&rft.atitle=Framework+for+considering+genetics+in+the+workplace.&rft.au=Schulte%2C+P+A&rft.aulast=Schulte&rft.aufirst=P&rft.date=2006-03-01&rft.volume=97&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=La+Medicina+del+lavoro&rft.issn=00257818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The contribution of occupational risks to the global burden of disease: summary and next steps. AN - 68918723; 17017364 AB - The Comparative Risk Assessment (CRA) project of the World Health Organization (WHO) assessed worldwide mortality and morbidity in the year 2000 resulting from exposures to selected occupational hazards. This article summarizes findings of the WHO CRA project, presents the estimates of the International Labor Organization (ILO) for total deaths due to workplace risks, and calls for action. Global burden estimates and counts of deaths assist ministers and other decision and policy makers to make informed decisions and to take action regarding risk reduction. The WHO CRA methodology combined the proportions of the population exposed to five occupational hazards (excluding numerous risks due to inadequate global data) with relative risk measures to estimate attributable fractions of the selected health outcomes for both morbidity and mortality. ILO estimates of total numbers of global work-related injury deaths apply national fatality rates to employment data for the particular country; for disease deaths ILO uses an attributable risk approach. In 2000, the selected occupational risk factors were responsible worldwide for 37% of back pain, 16% of hearing loss, 13% of chronic obstructive pulmonary disease (COPD), 11% of asthma, 8% of injuries, 9% of lung cancer and 2% of leukemia, and about 100% of pneumoconioses and mesothelioma. These selected risks at work resulted in the loss of about 24 million years of healthy life and caused 850,000 deaths worldwide, about 40% of the ILO estimate of 2.2 million total deaths. These global and regional analyses have identified areas where specific preventive actions are required. JF - La Medicina del lavoro AU - Fingerhut, Marilyn AU - Nelson, Deborah Imel AU - Driscoll, T AU - Concha-Barrientos, Marisol AU - Steenland, Kyle AU - Punnett, Laura AU - Prüss-Ustün, Annette AU - Leigh, J AU - Corvalan, C AU - Eijkemans, G AU - Takala, J AD - National Institute for Occupational Safety and Health, Room 715H, Humphrey Building, 200 Independence Avenue SW, Washington, DC 20201, USA. mfingerhut@cdc.gov PY - 2006 SP - 313 EP - 321 VL - 97 IS - 2 SN - 0025-7818, 0025-7818 KW - Index Medicus KW - Asthma -- epidemiology KW - Wounds and Injuries -- epidemiology KW - Back Pain -- etiology KW - Wounds and Injuries -- etiology KW - Humans KW - Infectious Disease Transmission, Patient-to-Professional -- statistics & numerical data KW - Hepatitis, Viral, Human -- epidemiology KW - Risk Assessment KW - Back Pain -- epidemiology KW - World Health Organization KW - Hearing Loss -- epidemiology KW - Life Expectancy KW - Data Collection KW - HIV Infections -- epidemiology KW - Occupational Health KW - Asthma -- etiology KW - HIV Infections -- transmission KW - Pulmonary Disease, Chronic Obstructive -- epidemiology KW - Neoplasms -- epidemiology KW - Pulmonary Disease, Chronic Obstructive -- etiology KW - Risk Factors KW - Hepatitis, Viral, Human -- transmission KW - Chronic Disease KW - Accidents, Occupational -- mortality KW - Hearing Loss -- etiology KW - Neoplasms -- etiology KW - Global Health KW - Risk KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68918723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=La+Medicina+del+lavoro&rft.atitle=The+contribution+of+occupational+risks+to+the+global+burden+of+disease%3A+summary+and+next+steps.&rft.au=Fingerhut%2C+Marilyn%3BNelson%2C+Deborah+Imel%3BDriscoll%2C+T%3BConcha-Barrientos%2C+Marisol%3BSteenland%2C+Kyle%3BPunnett%2C+Laura%3BPr%C3%BCss-Ust%C3%BCn%2C+Annette%3BLeigh%2C+J%3BCorvalan%2C+C%3BEijkemans%2C+G%3BTakala%2C+J&rft.aulast=Fingerhut&rft.aufirst=Marilyn&rft.date=2006-03-01&rft.volume=97&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=La+Medicina+del+lavoro&rft.issn=00257818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of consumer cosmetic products for phthalate esters. AN - 67958753; 16688376 AB - A rapid and sensitive reverse-phase HPLC method with UV detection was developed for the quantitation of dimethyl phthalate (DMP), diethyl phthalate (DEP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP) in cosmetic preparations. Average recoveries of the phthalate esters were better than 90%. In a survey of 48 consumer cosmetic products, including hair care products, deodorants, lotions and creams, nail products, fragrances, and body washes, most products were found to contain at least one phthalate ester. DEP was detected most frequently at concentrations up to 38,663 ppm. DBP was found in fewer products, but at levels up to 59,815 ppm. Based on the available exposure and toxicity data, the FDA has concluded that there is insufficient data to conclude that a human health hazard exists from exposure to phthalate esters from cosmetic products. JF - Journal of cosmetic science AU - Hubinger, Jean C AU - Havery, Donald C AD - U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. PY - 2006 SP - 127 EP - 137 VL - 57 IS - 2 SN - 1525-7886, 1525-7886 KW - Cosmetics KW - 0 KW - Esters KW - Phthalic Acids KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Chromatography, High Pressure Liquid KW - Phthalic Acids -- chemistry KW - Esters -- chemistry KW - Esters -- analysis KW - Cosmetics -- analysis KW - Phthalic Acids -- analysis KW - Cosmetics -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67958753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cosmetic+science&rft.atitle=Analysis+of+consumer+cosmetic+products+for+phthalate+esters.&rft.au=Hubinger%2C+Jean+C%3BHavery%2C+Donald+C&rft.aulast=Hubinger&rft.aufirst=Jean&rft.date=2006-03-01&rft.volume=57&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+cosmetic+science&rft.issn=15257886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA. AN - 67912214; 16645431 AB - New drugs that enhance metabolism or clearance of thyroid hormones in rats often trigger a sequence of toxicity events during chronic administration: reduction of thyroxine, elevation of thyroid-stimulating hormone (TSH) levels, and thyroid gland hyperfunction/growth. Hepatocellular hypertrophy and thyroid follicular hyperplasia are often observed with increased liver and thyroid organ weights. This unique toxicity profile seems to be species-specific because the thyroxine in rodents is metabolized rapidly, without thyroid hormone-binding globulin that serves as a reserve, as in humans. Thus, elevations of TSH were not reported in humans for drugs such as delavirdine, fluvastatin, nicardipine, phenobarbital, simvastatin, and spironolactone, all of which produce thyroid hyperplasia or tumors in rats. Further, the human thyroid is less sensitive to prolonged TSH stimulation than that of the rat (eg, endemic goiter patients with high TSH due to iodine deficiency do not develop thyroid cancer). In view of the species difference in sensitivity of the thyroid between rodents and humans, using the rat as an animal model to explore target organs of toxicity for a new drug that significantly enhances thyroid hormone metabolism/clearance and increases TSH levels would not be adequate. In this case, a compromised and dysfunctional hypothalamo-pituitary-thyroid system would confound the toxicity profile explored in preclinical toxicity testing and render the model an inadequate risk predictor for the new drug in humans. Under such conditions, IND and NDA sponsors of drugs exhibiting this activity profile should be encouraged to use alternative animal species for toxicity exploration to provide a more meaningful human risk prediction. JF - American journal of therapeutics AU - Wu, Kuei-Meng AU - Farrelly, James G AD - HFD-530, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA. wuk@cder.fda.gov PY - 2006 SP - 141 EP - 144 VL - 13 IS - 2 SN - 1075-2765, 1075-2765 KW - Drugs, Investigational KW - 0 KW - Thyroid Hormones KW - Index Medicus KW - Rats KW - Thyroid Neoplasms -- chemically induced KW - Animals KW - Risk Factors KW - Humans KW - Disease Models, Animal KW - Thyroid Neoplasms -- pathology KW - Predictive Value of Tests KW - Thyroid Hormones -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67912214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Preclinical+development+of+new+drugs+that+enhance+thyroid+hormone+metabolism+and+clearance%3A+inadequacy+of+using+rats+as+an+animal+model+for+predicting+human+risks+in+an+IND+and+NDA.&rft.au=Wu%2C+Kuei-Meng%3BFarrelly%2C+James+G&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2006-03-01&rft.volume=13&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=10752765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of Griess reagent containing vanadium(III) for post-column derivatization and simultaneous determination of nitrite and nitrate in baby food. AN - 67907195; 16640292 AB - An ion chromatographic method with post-column derivatization and spectrophotometric detection is presented for the determination of nitrate and nitrite (NOx) in baby food. NOx residues found naturally or added as preservatives were extracted from baby foods and determined by using ion chromatography with post-column derivatization and spectrophotometric detection. Nitrate was reduced to nitrite online by post-column reduction using vanadium(lll) chloride and heat. Nitrite reacted with Griess reagent to produce a dye that was detected at 525 nm. The use of V(III) and heat to promote the reduction of nitrate to nitrite online is a novel feature of this detection system. The determination of incurred NOx residues in samples by using AOAC Method 993.03 yielded results comparable to those obtained by ion chromatography with spectrophotometric detection. The toxic and carcinogenic metal cadmium used in the AOAC Method to reduce the nitrate to nitrite was avoided. The proposed method provides simultaneous determination of nitrate and nitrite. Average recoveries of nitrate and nitrite residues ranged from 82 to 107% for fortification levels of 25-400 ppm. JF - Journal of AOAC International AU - Casanova, John A AU - Gross, Lois K AU - McMullen, Sarah E AU - Schenck, Frank J AD - U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St NE, Atlanta, GA 30309, USA. PY - 2006 SP - 447 EP - 451 VL - 89 IS - 2 SN - 1060-3271, 1060-3271 KW - Ethylenediamines KW - 0 KW - Griess reagent KW - Indicators and Reagents KW - Nitrates KW - Nitrites KW - Solutions KW - Sulfanilamides KW - Vanadium KW - 00J9J9XKDE KW - Index Medicus KW - Vegetables -- chemistry KW - Humans KW - Reference Standards KW - Spectrophotometry, Ultraviolet KW - Infant, Newborn KW - Chromatography, Ion Exchange KW - Fruit -- chemistry KW - Chromatography, High Pressure Liquid KW - Nitrites -- analysis KW - Sulfanilamides -- chemistry KW - Infant Food -- analysis KW - Nitrates -- analysis KW - Vanadium -- chemistry KW - Ethylenediamines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67907195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Use+of+Griess+reagent+containing+vanadium%28III%29+for+post-column+derivatization+and+simultaneous+determination+of+nitrite+and+nitrate+in+baby+food.&rft.au=Casanova%2C+John+A%3BGross%2C+Lois+K%3BMcMullen%2C+Sarah+E%3BSchenck%2C+Frank+J&rft.aulast=Casanova&rft.aufirst=John&rft.date=2006-03-01&rft.volume=89&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased susceptibility of hyperthyroid rats to ozone: early events and mechanisms. AN - 67819587; 16574622 AB - Previous studies demonstrated that ozone-induced lung damage and inflammation are much greater in hyperthyroid rats, compared to normal rats, at 18 h postexposure. The purpose of the present investigation was to study early events and mechanisms underlying the increased sensitivity to ozone in a hyperthyroid state. Specifically, the degree of lung epithelial cell barrier disruption, the antioxidant status of the extracellular lining fluid, and the release of inflammatory mediators were examined. To induce a hyperthyroid state, mature male Sprague-Dawley rats were implanted with time-release pellets containing thyroxine; control rats received placebo pellets. After 7 d, the animals were exposed to air or ozone (2 ppm, 3 h). Immediately following the end of the exposure, bronchoalveolar lavage (BAL) fluid and cells were harvested. BAL fluid albumin levels and total antioxidant status were examined. In addition, levels of prostaglandin E2 (PGE2), macrophage inflammatory protein (MIP)-2, MCP-1, and tumor necrosis factor (TNF)-alpha were determined in BAL fluid and in media samples following ex vivo culture of BAL cells harvested after in vivo inhalation exposures. The results of this study are consistent with the following hypotheses: (1) A marked increase in the permeability of the alveolar-capillary barrier is an early event following ozone exposure in a hyperthyroid state; however this does not appear to be due to overall changes in BAL fluid antioxidant potential. (2) Early increases in MIP-2, but not PGE2, are involved in the enhanced lung response to ozone in a hyperthyroid state. (3) Inflammatory mediator production (i.e., PGE2, MIP-2, MCP-1, and TNF-alpha) by alveolar macrophages plays a minimal role in the initial responses to ozone in a hyperthyroid state. JF - Journal of toxicology and environmental health. Part A AU - Huffman, L J AU - Beighley, C M AU - Frazer, D G AU - McKinney, W G AU - Porter, D W AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. ljh3@cdc.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 465 EP - 479 VL - 69 IS - 6 SN - 1528-7394, 1528-7394 KW - Antioxidants KW - 0 KW - Chemokine CCL4 KW - Chemokine CXCL2 KW - Macrophage Inflammatory Proteins KW - Monokines KW - Oxidants, Photochemical KW - Tumor Necrosis Factor-alpha KW - Ozone KW - 66H7ZZK23N KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Antioxidants -- analysis KW - Animals KW - Macrophage Inflammatory Proteins -- analysis KW - Lung -- cytology KW - Cell Culture Techniques KW - Macrophages, Alveolar -- drug effects KW - Pulmonary Alveoli -- physiology KW - Dinoprostone -- analysis KW - Monokines -- analysis KW - Macrophages, Alveolar -- physiology KW - Inflammation KW - Rats KW - Permeability KW - Rats, Sprague-Dawley KW - Epithelial Cells KW - Tumor Necrosis Factor-alpha -- analysis KW - Pulmonary Alveoli -- drug effects KW - Male KW - Oxidants, Photochemical -- toxicity KW - Hyperthyroidism -- complications KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67819587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Increased+susceptibility+of+hyperthyroid+rats+to+ozone%3A+early+events+and+mechanisms.&rft.au=Huffman%2C+L+J%3BBeighley%2C+C+M%3BFrazer%2C+D+G%3BMcKinney%2C+W+G%3BPorter%2C+D+W&rft.aulast=Huffman&rft.aufirst=L&rft.date=2006-03-01&rft.volume=69&rft.issue=6&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure in vivo to silica or lipopolysaccharide produces transient or sustained upregulation, respectively, of PYPAF7 and MEFV genes in bronchoalveolar lavage cells in rats. AN - 67818230; 16574623 AB - A family of proteins containing PAAD [for PYRIN, AIM (absent in melanoma), apoptosis-associated protein speck-like protein containing a caspase recruitment domain, and death domain] domain was found to be involved in modulating inflammatory responses, by its ability to regulate nuclear factor (NF)-kappaB and procaspase-1 activation. In this study, intratracheal instillation of silica in rats was found to produce transient upregulation of mRNA levels of the PAAD family of proteins, PYPAF7 (PYRIN containing Apaf1-like protein; Apaf stands for apoptosis activating factor) and MEFV (for Mediterranean fever), in bronchoalveolar lavage (BAL) cells. The levels were markedly elevated at 4 h, returning to basal levels by 24 h. In contrast, intratracheal instillation of LPS produced a sustained upregulation of the two genes in BAL cells. In vitro exposure of BAL cells to silica or lipopolysaccharide (LPS) produced no changes in the expression of these genes, indicating that silica or LPS exposure in vivo induces some factors that are responsible for the upregulation of PYPAF7 and MEFV. The mRNA levels of these two genes in peripheral blood monocytes and PMN following LPS exposure did not change, indicating that AM and peripheral blood cells show similar response to LPS exposure in vitro. This study provides the basis for a physiological model to study the effects of these two genes in modulating the inflammatory response after particle exposure. JF - Journal of toxicology and environmental health. Part A AU - Rao, K Murali Krishna AU - Meighan, Terence AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. mir8@cdc.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 481 EP - 490 VL - 69 IS - 6 SN - 1528-7394, 1528-7394 KW - Apoptosis Regulatory Proteins KW - 0 KW - Cytoskeletal Proteins KW - Lipopolysaccharides KW - Pyrin KW - RNA, Messenger KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Sprague-Dawley KW - Particle Size KW - Up-Regulation KW - Monocytes KW - Bronchoalveolar Lavage Fluid -- cytology KW - RNA, Messenger -- biosynthesis KW - Inflammation KW - Cytoskeletal Proteins -- biosynthesis KW - Silicon Dioxide -- toxicity KW - Lipopolysaccharides -- toxicity KW - Apoptosis Regulatory Proteins -- physiology KW - Apoptosis Regulatory Proteins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67818230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Exposure+in+vivo+to+silica+or+lipopolysaccharide+produces+transient+or+sustained+upregulation%2C+respectively%2C+of+PYPAF7+and+MEFV+genes+in+bronchoalveolar+lavage+cells+in+rats.&rft.au=Rao%2C+K+Murali+Krishna%3BMeighan%2C+Terence&rft.aulast=Rao&rft.aufirst=K+Murali&rft.date=2006-03-01&rft.volume=69&rft.issue=6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris. AN - 67799192; 16450379 AB - Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are likely to cause osteolysis. Because multipotent mesenchymal stem cells (MSCs) located adjacent to the implant have an osteoprogenitor function and are critical contributors to osseous tissue integrity, when their functions or activities are compromised, osteolysis will most likely occur. To date, it is not certain or sufficiently confirmed whether MSCs endocytose titanium particles, and if so, whether particulate endocytosis has any effect on cellular responses to wear debris. This study seeks to clarify the phenomenon of titanium endocytosis by human MSCs (hMSCs), and investigates the influence of endocytosis on their activities. hMSCs incubated with commercially pure titanium particles exhibited internalized particles, as observed by scanning electron microscopy and confocal laser scanning microscopy, with time-dependent reduction in the number of extracellular particles. Particulate endocytosis was associated with reduced rates of cellular proliferation and cell-substrate adhesion, suppressed osteogenic differentiation, and increased rate of apoptosis. These cellular effects of exposure to titanium particles were reduced when endocytosis was inhibited by treatment with cytochalasin D, and no significant effect was seen when hMSCs were treated only with conditioned medium obtained from particulate-treated cells. These findings strongly suggest that the biological responses of hMSCs to wear debris are triggered primarily by the direct endocytosis of titanium particulates, and not mediated by secreted soluble factors. In this manner, therapeutical approaches that suppress particle endocytosis could reduce the bioreactivity of hMSCs to particulates, and enhance long-term orthopedic implant prognosis by minimizing wear-debris periprosthethic osteolysis. Copyright 2006 Orthopaedic Research Society. JF - Journal of orthopaedic research : official publication of the Orthopaedic Research Society AU - Okafor, Chukwuka C AU - Haleem-Smith, Hana AU - Laqueriere, Patrice AU - Manner, Paul A AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC8022, Department of Health and Human Services, Bethesda, Maryland 20892-8022, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 461 EP - 473 VL - 24 IS - 3 SN - 0736-0266, 0736-0266 KW - Cytochalasin D KW - 22144-77-0 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Osteolysis KW - Cell Proliferation -- drug effects KW - Microscopy, Confocal KW - Humans KW - Arthroplasty, Replacement -- methods KW - Cells, Cultured KW - Apoptosis -- drug effects KW - Arthroplasty, Replacement -- adverse effects KW - Cytochalasin D -- pharmacology KW - Osteogenesis -- drug effects KW - Cell Adhesion -- drug effects KW - Cell Differentiation -- drug effects KW - Arthroplasty, Replacement -- instrumentation KW - Mesenchymal Stromal Cells -- ultrastructure KW - Mesenchymal Stromal Cells -- drug effects KW - Titanium -- adverse effects KW - Joint Prosthesis -- adverse effects KW - Endocytosis -- drug effects KW - Titanium -- metabolism KW - Mesenchymal Stromal Cells -- metabolism KW - Endocytosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67799192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.atitle=Particulate+endocytosis+mediates+biological+responses+of+human+mesenchymal+stem+cells+to+titanium+wear+debris.&rft.au=Okafor%2C+Chukwuka+C%3BHaleem-Smith%2C+Hana%3BLaqueriere%2C+Patrice%3BManner%2C+Paul+A%3BTuan%2C+Rocky+S&rft.aulast=Okafor&rft.aufirst=Chukwuka&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.issn=07360266&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester. AN - 67763389; 16544937 AB - Diisocyanates (dNCOs) are the most commonly reported cause of chemically induced occupational asthma, but the ultimate antigenic form is unknown. Reactions of the three most common monomeric dNCOs, hexamethylene dNCO (HDI), methylene diphenylisocyanate (MDI), and toluene dNCO (TDI), with cysteine methyl ester (CME) gave the corresponding bis-dithiocarbamates (HDI-CME, TDI-CME, and MDI-CME). The dissociation kinetics of these bis-thiocarbamates, in aqueous conditions, was followed spectrophotometrically under varying pH and temperature conditions. Reaction of the adducts with methylamine or human serum albumin (HSA) produced diurea, monourea, and diamine products, and this was consistent with the base-catalyzed elimination reaction (E1cB) pathway being the dominant, but not exclusive, dissociation mechanism. The hydrolysis of the adducts was first-order with respect to OH(-) concentration and overall second-order (HDI-CME, k = 3.36 x 10(2) M(-)(1) min(-)(1); TDI-CME, k = 2.49 x 10(4) M(-)(1) min(-)(1); and MDI-CME, k = 5.78 x 10(4) M(-)(1) min(-)(1) at pH 7.4) with deviation from second-order when the dNCO had an aromatic functional group. Arrhenius plots gave activation energies (HDI-CME, E(a) = 70.6 kJ/mol; TDI-CME, E(a) = 46.1 kJ/mol; and MDI-CME, E(a) = 44.5 kJ/mol) that were consistent with the following order of stability: HDI-CME > TDI-CME > MDI-CME. Therefore, the stability of different dNCO-derived thiocarbamates in aqueous environments can vary greatly. Thiocarbamate dissociation rates and type of products formed may potentially influence antigenicity and subsequent hypersensitivity/toxic reactions following dNCO exposures. JF - Chemical research in toxicology AU - Chipinda, Itai AU - Stetson, Sarah J AU - Depree, Gary J AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 341 EP - 350 VL - 19 IS - 3 SN - 0893-228X, 0893-228X KW - Indicators and Reagents KW - 0 KW - Isocyanates KW - Methylamines KW - Thiocarbamates KW - Cysteine KW - K848JZ4886 KW - mecysteine KW - RQ6L463N3B KW - Index Medicus KW - Half-Life KW - Methylamines -- chemical synthesis KW - Kinetics KW - Hydrogen-Ion Concentration KW - Temperature KW - Algorithms KW - Models, Chemical KW - Hydrolysis KW - Chromatography, High Pressure Liquid KW - Cysteine -- chemistry KW - Thiocarbamates -- chemistry KW - Isocyanates -- chemistry KW - Cysteine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67763389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Kinetics+and+mechanistic+studies+of+the+hydrolysis+of+diisocyanate-derived+bis-thiocarbamates+of+cysteine+methyl+ester.&rft.au=Chipinda%2C+Itai%3BStetson%2C+Sarah+J%3BDepree%2C+Gary+J%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2006-03-01&rft.volume=19&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications. AN - 67761509; 16544941 AB - 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and 17-allylamino-17-demethoxygeldanamycin (17-AAG) are two derivatives of geldanamycin (GA) that are currently undergoing clinical evaluation as anticancer agents. These agents bind to heat shock protein 90 (hsp90), resulting in the destabilization of client proteins and inhibition of tumor growth. In a search for the mechanism of hepatotoxicity, which is a dose-limiting toxicity for these agents, we found that GA and its derivatives, 17-AAG and 17-DMAG, react chemically (i.e., nonenzymatically) with glutathione (GSH). A combination of liquid chromatography/electrospray ionization/mass spectrometry and nuclear magnetic resonance analyses were used to identify the product of this reaction as a GSH adduct in which the thiol group of GSH is substituted in the 19-position of the benzoquinone ring. The reaction proceeds rapidly with GA and 17-DMAG (half-lives of approximately 1.5 and 36 min, respectively) and less rapidly with 17-AAG and its major metabolite, 17-AG (half-lives of approximately 9.8 and 16.7 h). The reaction occurs at pH 7.0, 37 degrees C, and a physiological concentration of GSH, indicating that cellular GSH could play a role in modulating the cellular toxicity of these agents and therefore be a factor in their mechanism of differential toxicity. Moreover, reactions with thiol groups of critical cellular proteins could be important to the mechanism of toxicity with this class of anticancer agents. JF - Chemical research in toxicology AU - Cysyk, Richard L AU - Parker, Robert J AU - Barchi, Joseph J AU - Steeg, Patricia S AU - Hartman, Neil R AU - Strong, John M AD - Laboratory of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 376 EP - 381 VL - 19 IS - 3 SN - 0893-228X, 0893-228X KW - Antibiotics, Antineoplastic KW - 0 KW - Benzoquinones KW - Buffers KW - HSP90 Heat-Shock Proteins KW - Lactams, Macrocyclic KW - Phosphates KW - Quinones KW - Sulfhydryl Compounds KW - Glutathione KW - GAN16C9B8O KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Mass Spectrometry KW - Drug Stability KW - Sulfhydryl Compounds -- chemistry KW - Phosphates -- chemistry KW - HSP90 Heat-Shock Proteins -- chemistry KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Quinones -- chemistry KW - Antibiotics, Antineoplastic -- chemistry KW - Glutathione -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67761509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Reaction+of+geldanamycin+and+C17-substituted+analogues+with+glutathione%3A+product+identifications+and+pharmacological+implications.&rft.au=Cysyk%2C+Richard+L%3BParker%2C+Robert+J%3BBarchi%2C+Joseph+J%3BSteeg%2C+Patricia+S%3BHartman%2C+Neil+R%3BStrong%2C+John+M&rft.aulast=Cysyk&rft.aufirst=Richard&rft.date=2006-03-01&rft.volume=19&rft.issue=3&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial. AN - 67748781; 16537707 AB - Pro- and anti-inflammatory cytokine genes may be important in the maintenance and progression of colorectal cancer. It is possible that single-nucleotide polymorphisms in inflammatory genes may play a role in chronic colonic inflammation and development of colorectal adenomas. Furthermore, common variants in cytokine genes may modify the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer. We examined the association between cytokine gene polymorphisms and risk of recurrent adenomas among 1,723 participants in the Polyp Prevention Trial. We used logistic regression to calculate odds ratios (OR) for the association between genotype, NSAID use, and risk of adenoma recurrence. Cytokine gene polymorphisms were not statistically significantly associated with risk of adenoma recurrence in our study. We observed statistically significant interactions between NSAID use, IL-10 -1082 G>A genotype, and risk of adenoma recurrence (P = 0.01) and multiple adenoma recurrence (P = 0.01). Carriers of the IL-10 -1082 G>A variant allele who were non-NSAID users had a statistically significant decreased risk of multiple adenoma recurrence (OR, 0.43; 95% confidence interval, 0.24-0.77) as well as a nonsignificant 30% decreased risk of any adenoma recurrence. In contrast, NSAID users who were carriers of the IL-10 -1082 G>A variant allele were at an increased risk of any adenoma recurrence (OR, 1.55; 95% confidence interval, 1.00-2.43). These findings suggest that individuals who are carriers of the IL-10 -1082 G>A variant allele may not benefit from the chemoprotective effect of NSAIDs on adenoma polyp recurrence. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Sansbury, Leah B AU - Bergen, Andrew W AU - Wanke, Kay L AU - Yu, Binbing AU - Caporaso, Neil E AU - Chatterjee, Nilanjan AU - Ratnasinghe, Luke AU - Schatzkin, Arthur AU - Lehman, Teresa A AU - Kalidindi, Aravind AU - Modali, Ramakrishna AU - Lanza, Elaine AD - Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Suite 702, 6116 Executive Boulevard, MSC 8235, Bethesda, MD 20892-8325, USA. sansburl@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 494 EP - 501 VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Biomarkers, Tumor KW - Cytokines KW - Index Medicus KW - Sensitivity and Specificity KW - Genetic Variation KW - Odds Ratio KW - Neoplasm Staging KW - Humans KW - Aged KW - Biopsy, Needle KW - Risk Assessment KW - Polymerase Chain Reaction KW - Colonoscopy KW - Survival Rate KW - Logistic Models KW - Biomarkers, Tumor -- analysis KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Male KW - Colorectal Neoplasms -- mortality KW - Cytokines -- drug effects KW - Cytokines -- genetics KW - Neoplasm Recurrence, Local -- epidemiology KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Polymorphism, Genetic KW - Adenomatous Polyps -- therapy KW - Adenomatous Polyps -- pathology KW - Cytokines -- metabolism KW - Neoplasm Recurrence, Local -- prevention & control KW - Adenomatous Polyps -- mortality KW - Colorectal Neoplasms -- pathology KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Colorectal Neoplasms -- therapy KW - Neoplasm Recurrence, Local -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67748781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Inflammatory+cytokine+gene+polymorphisms%2C+nonsteroidal+anti-inflammatory+drug+use%2C+and+risk+of+adenoma+polyp+recurrence+in+the+polyp+prevention+trial.&rft.au=Sansbury%2C+Leah+B%3BBergen%2C+Andrew+W%3BWanke%2C+Kay+L%3BYu%2C+Binbing%3BCaporaso%2C+Neil+E%3BChatterjee%2C+Nilanjan%3BRatnasinghe%2C+Luke%3BSchatzkin%2C+Arthur%3BLehman%2C+Teresa+A%3BKalidindi%2C+Aravind%3BModali%2C+Ramakrishna%3BLanza%2C+Elaine&rft.aulast=Sansbury&rft.aufirst=Leah&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suggestions for preventing musculoskeletal disorders in home healthcare workers. Part 1: lift and transfer assistance for partially weight-bearing home care patients. AN - 67739853; 16531777 AB - Home healthcare is one of the fastest-growing professions, currently employing more than 1 million workers in the United States. Unfortunately, these workers sustain an exceptionally high rate of musculoskeletal disorders. This is the first article in a two-part series providing information and suggestions for preventing overexertion that can lead to such disorders. JF - Home healthcare nurse AU - Parsons, Kelley S AU - Galinsky, Traci L AU - Waters, Thomas AD - National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226, USA. kparsons@cdc.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 158 EP - 64; quiz 165-6 VL - 24 IS - 3 SN - 0884-741X, 0884-741X KW - Nursing KW - United States KW - Occupational Health KW - Human Engineering KW - Self-Help Devices KW - Nursing Assessment KW - Humans KW - Activities of Daily Living KW - Weight-Bearing KW - Accidents, Occupational -- prevention & control KW - Musculoskeletal Diseases -- etiology KW - Musculoskeletal Diseases -- prevention & control KW - Home Care Services KW - Transportation of Patients -- methods KW - Lifting -- adverse effects KW - Community Health Nursing -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67739853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+healthcare+nurse&rft.atitle=Suggestions+for+preventing+musculoskeletal+disorders+in+home+healthcare+workers.+Part+1%3A+lift+and+transfer+assistance+for+partially+weight-bearing+home+care+patients.&rft.au=Parsons%2C+Kelley+S%3BGalinsky%2C+Traci+L%3BWaters%2C+Thomas&rft.aulast=Parsons&rft.aufirst=Kelley&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Home+healthcare+nurse&rft.issn=0884741X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Availability of behavioral health treatment for women in prison. AN - 67736003; 16524993 AB - This study examined whether women with behavioral health needs are more likely to receive treatment for these problems in prison or in the community and to what extent prison disrupts or establishes involvement in treatment for these women. Data were collected in August 2004 as part of a population survey of female inmates in the only state correctional facility for women in New Jersey. A total of 908 women were surveyed. Fifty-six percent of the women surveyed reported needing behavioral health treatment before incarceration, but only 62 percent of this group reported receiving such treatment in the community. The rate at which treatment matched need within this population before incarceration varied by type of treatment needed: it was the highest (58 percent) for women who needed treatment for mental health problems, lower (52 percent) for those who needed substance abuse treatment, and lowest (44 percent) for those who needed treatment for comorbid mental health and substance abuse problems. In comparison, the rate of match between need for and receipt of treatment in prison was higher for all three types of behavioral health treatment (78 percent, 57 percent, and 65 percent, respectively). Additionally, the findings suggest that prison did not disrupt the type of behavioral health treatment that inmates had previously received in the community. At least in New Jersey, prison appears to improve access to behavioral health treatment among female inmates. Although this conclusion is consistent with the rehabilitation goals of incarceration, it also suggests that some women may have been able to avoid prison if treatment had been provided in the community, especially for substance-related problems. JF - Psychiatric services (Washington, D.C.) AU - Blitz, Cynthia L AU - Wolff, Nancy AU - Paap, Kris AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, New Jersey 08901, USA. clblitz@rci.rutgers.edu Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 356 EP - 360 VL - 57 IS - 3 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - New Jersey -- epidemiology KW - Humans KW - Female KW - Comorbidity KW - Deinstitutionalization KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Prisons KW - Mental Disorders -- diagnosis KW - Community Mental Health Services -- organization & administration KW - Mental Disorders -- therapy KW - Behavior Therapy KW - Needs Assessment -- organization & administration KW - Mental Disorders -- epidemiology KW - Prisoners KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67736003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Availability+of+behavioral+health+treatment+for+women+in+prison.&rft.au=Blitz%2C+Cynthia+L%3BWolff%2C+Nancy%3BPaap%2C+Kris&rft.aulast=Blitz&rft.aufirst=Cynthia&rft.date=2006-03-01&rft.volume=57&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Law Psychiatry. 2001 Jan-Feb;24(1):1-11 [11346988] Can J Psychiatry. 2004 Aug;49(8):539-50 [15453103] Arch Gen Psychiatry. 2001 Aug;58(8):787-94 [11483146] J Am Acad Psychiatry Law. 2002;30(1):19-29; discussion 30-2 [11931366] Soc Sci Med. 1987;24(3):187-96 [3824001] Psychiatr Serv. 1998 Apr;49(4):483-92 [9550238] Psychiatr Serv. 1998 Sep;49(9):1229-31 [9735969] Int J Law Psychiatry. 1999 May-Aug;22(3-4):301-22 [10457926] New Dir Ment Health Serv. 1987 Winter;(36):33-45 [3325810] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of portable XRF and ICP-OES analysis for lead on air filter samples from a lead ore concentrator mill and a lead-acid battery recycler. AN - 67735598; 16528423 AB - Personal and area samples for airborne lead were taken at a lead mine concentrator mill, and at a lead-acid battery recycler. Lead is mined as its sulfidic ore, galena, which is often associated with zinc and silver. The ore typically is concentrated, and partially separated, on site by crushing and differential froth flotation of the ore minerals before being sent to a primary smelter. Besides lead, zinc and iron are also present in the airborne dusts, together with insignificant levels of copper and silver, and, in one area, manganese. The disposal of used lead-acid batteries presents environmental issues, and is also a waste of recoverable materials. Recycling operations allow for the recovery of lead, which can then be sold back to battery manufacturers to form a closed loop. At the recycling facility lead is the chief airborne metal, together with minor antimony and tin, but several other metals are generally present in much smaller quantities, including copper, chromium, manganese and cadmium. Samplers used in these studies included the closed-face 37 mm filter cassette (the current US standard method for lead sampling), the 37 mm GSP or "cone" sampler, the 25 mm Institute of Occupational Medicine (IOM) inhalable sampler, the 25 mm Button sampler, and the open-face 25 mm cassette. Mixed cellulose-ester filters were used in all samplers. The filters were analyzed after sampling for their content of the various metals, particularly lead, that could be analyzed by the specific portable X-ray fluorescence (XRF) analyzer under study, and then were extracted with acid and analyzed by inductively coupled plasma optical emission spectroscopy (ICP-OES). The 25 mm filters were analyzed using a single XRF reading, while three readings on different parts of the filter were taken from the 37 mm filters. For lead at the mine concentrate mill, all five samplers gave good correlations (r2 > 0.96) between the two analytical methods over the entire range of found lead mass, which encompassed the permissible exposure limit of 150 mg m(-3) enforced in the USA by the Mine Safety and Health Administration (MSHA). Linear regression on the results from most samplers gave almost 1 ratio 1 correlations without additional correction, indicating an absence of matrix effects from the presence of iron and zinc in the samples. An approximately 10% negative bias was found for the slope of the Button sampler regression, in line with other studies, but it did not significantly affect the accuracy as all XRF results from this sampler were within 20% of the corresponding ICP values. As in previous studies, the best results were obtained with the GSP sampler using the average of three readings, with all XRF results within 20% of the corresponding ICP values and a slope close to 1 (0.99). Greater than 95% of XRF results were within 20% of the corresponding ICP values for the closed-face 37 mm cassette using the OSHA algorithm, and the IOM sampler using a sample area of 3.46 cm2. As in previous studies, considerable material was found on the interior walls of all samplers that possess an internal surface for deposition, at approximately the same proportion for all samplers. At the lead-acid battery recycler all five samplers in their optimal configurations gave good correlations (r2 > 0.92) between the two analytical methods over the entire range of found lead mass, which included the permissible exposure limit enforced in the USA by the Occupational Safety and Health Administration (OSHA). Linear regression on the results from most samplers gave almost 1 ratio 1 correlations (except for the Button sampler), indicating an absence of matrix effects from the presence of the smaller quantities of the other metals in the samples. A negative bias was found for the slope of the button sampler regression, in line with other studies. Even though very high concentrations of lead were encountered (up to almost 6 mg m(-3)) no saturation of the detector was observed. Most samplers performed well, with >90% of XRF results within +/- 25% of the corresponding ICP results for the optimum configurations. The OSHA algorithm for the CFC worked best without including the back-up pad with the filter. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Pacolay, Bruce AU - Hintz, Patrick AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 384 EP - 392 VL - 8 IS - 3 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Filtration KW - Spectrophotometry, Atomic -- methods KW - Inhalation Exposure -- analysis KW - Electric Power Supplies KW - Occupational Exposure -- standards KW - Humans KW - Conservation of Natural Resources KW - Spectrometry, X-Ray Emission -- methods KW - Air Pollutants, Occupational -- analysis KW - Lead -- analysis KW - Metallurgy KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67735598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=A+comparison+of+portable+XRF+and+ICP-OES+analysis+for+lead+on+air+filter+samples+from+a+lead+ore+concentrator+mill+and+a+lead-acid+battery+recycler.&rft.au=Harper%2C+Martin%3BPacolay%2C+Bruce%3BHintz%2C+Patrick%3BAndrew%2C+Michael+E&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2006-03-01&rft.volume=8&rft.issue=3&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-08 N1 - Date created - 2006-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicidality in pediatric patients treated with antidepressant drugs. AN - 67723588; 16520440 AB - There has been concern that widely used antidepressant agents might be associated with an increased risk of suicidal ideation and behavior (suicidality) in pediatric patients. To investigate the relationship between antidepressant drugs and suicidality in pediatric patients participating in randomized, placebo-controlled trials. Data were derived from 23 trials conducted in 9 drug company-supported programs evaluating the effectiveness of antidepressants in pediatric patients and 1 multicenter trial (the Treatment for Adolescents With Depression Study) that evaluated fluoxetine hydrochloride. All placebo-controlled trials submitted to the Food and Drug Administration were eligible for inclusion. Evaluable data were derived from 4582 patients in 24 trials. Sixteen trials studied patients with major depressive disorder, and the remaining 8 studied obsessive-compulsive disorder (n = 4), generalized anxiety disorder (n = 2), attention-deficit/hyperactivity disorder (n = 1), and social anxiety disorder (n = 1). Only 20 trials were included in the risk ratio analysis of suicidality because 4 trials had no events in the drug or placebo groups. Individual patient data were available for all the trials. A meta-analysis was conducted to obtain overall suicidality risk estimates for each drug individually, for selective serotonin reuptake inhibitors in depression trials as a group, and for all evaluable trials combined. There were no completed suicides in any of these trials. The multicenter trial was the only individual trial to show a statistically significant risk ratio (4.62; 95% confidence interval [CI], 1.02-20.92). The overall risk ratio for selective serotonin reuptake inhibitors in depression trials was 1.66 (95% CI, 1.02-2.68) and for all drugs across all indications was 1.95 (95% CI, 1.28-2.98). The overall risk difference for all drugs across all indications was 0.02 (95% CI, 0.01-0.03). Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality. JF - Archives of general psychiatry AU - Hammad, Tarek A AU - Laughren, Thomas AU - Racoosin, Judith AD - Division of Neuropharmacological Drug Products, HFD-120, 5600 Fishers Lane, Rockville, MD 20857, USA. laughren@cder.fda.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 332 EP - 339 VL - 63 IS - 3 SN - 0003-990X, 0003-990X KW - Antidepressive Agents KW - 0 KW - Placebos KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Abridged Index Medicus KW - Index Medicus KW - Depressive Disorder, Major -- diagnosis KW - Fluoxetine -- adverse effects KW - Age Factors KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Humans KW - Child KW - Serotonin Uptake Inhibitors -- adverse effects KW - Risk Assessment KW - Depressive Disorder, Major -- drug therapy KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Depressive Disorder, Major -- psychology KW - Treatment Outcome KW - Fluoxetine -- therapeutic use KW - Multicenter Studies as Topic -- statistics & numerical data KW - Adolescent KW - Female KW - Male KW - Randomized Controlled Trials as Topic -- statistics & numerical data KW - Mental Disorders -- diagnosis KW - Mental Disorders -- drug therapy KW - Antidepressive Agents -- therapeutic use KW - Mental Disorders -- psychology KW - Antidepressive Agents -- adverse effects KW - Suicide -- statistics & numerical data KW - Suicide -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67723588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Suicidality+in+pediatric+patients+treated+with+antidepressant+drugs.&rft.au=Hammad%2C+Tarek+A%3BLaughren%2C+Thomas%3BRacoosin%2C+Judith&rft.aulast=Hammad&rft.aufirst=Tarek&rft.date=2006-03-01&rft.volume=63&rft.issue=3&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-29 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Gen Psychiatry. 2006 Mar;63(3):246-8 [16520428] Evid Based Ment Health. 2007 Feb;10(1):20 [17255389] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deaths attributed to X-ray contrast media on U.S. death certificates. AN - 67691644; 16498085 AB - The objectives of our study were to determine the number, rate, and types of deaths attributed to specific X-ray contrast media on the basis of U.S. death certificates and to attempt to assess the comparative safety of commonly used diagnostic X-ray contrast agents using death certificate information. From 1999 through 2001, deaths attributed to the International Classification of Diseases (ICD) code for contrast media occurred at the rate of 1.1-1.2 per million contrast media packages distributed. An analysis of 1999 death certificates indicated that most deaths attributed to contrast media predictably were associated with renal failure or nephropathy and anaphylaxis or allergic reactions. Risk assessment of the comparative safety of classes or agents was limited by lack of specific contrast media names. Names of administered contrast agents should be recorded in patients' medical records and communicated to primary care physicians and certifiers of death in the event of serious sequelae after an identified recent radiologic procedure. JF - AJR. American journal of roentgenology AU - Wysowski, Diane K AU - Nourjah, Parivash AD - Division of Drug Risk Evaluation, Food and Drug Administration, HFD-433, Silver Spring, MD 20993, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 613 EP - 615 VL - 186 IS - 3 SN - 0361-803X, 0361-803X KW - Contrast Media KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Death Certificates KW - United States -- epidemiology KW - Contrast Media -- adverse effects KW - Diagnostic Imaging KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67691644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AJR.+American+journal+of+roentgenology&rft.atitle=Deaths+attributed+to+X-ray+contrast+media+on+U.S.+death+certificates.&rft.au=Wysowski%2C+Diane+K%3BNourjah%2C+Parivash&rft.aulast=Wysowski&rft.aufirst=Diane&rft.date=2006-03-01&rft.volume=186&rft.issue=3&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=AJR.+American+journal+of+roentgenology&rft.issn=0361803X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. AN - 67687356; 16495727 AB - This study assessed the effects of nicotine pre-exposure on subsequent locomotor and rewarding effects of repeated Delta-9-tetrahydrocannabinol administration in Sprague-Dawley rats. Repeated administration of the same dose of Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) did not produce significant tolerance or behavioral sensitization to Delta-9-tetrahydrocannabinol's locomotor effects. An unbiased place conditioning paradigm was then used to obtain a measure of the rewarding effects of Delta-9-tetrahydrocannabinol. Rats received an injection of either Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials) of a two-compartment apparatus. Control rats received saline injections associated with both compartments. Significant conditioned place preferences developed with 0.1 mg/kg Delta-9-tetrahydrocannabinol in control rats, but not in nicotine pre-exposed rats. Surprisingly, significant place aversions developed at higher 1 and 2 mg/kg doses of Delta-9-tetrahydrocannabinol in nicotine pre-exposed rats. To the extent that behavioral sensitization may reflect reward processes in drug dependence, the lack of behavioral sensitization on repeated Delta-9-tetrahydrocannabinol administration is consistent with the difficulties usually encountered in demonstrating rewarding or reinforcing effects of Delta-9-tetrahydrocannabinol in rats. The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol. JF - Behavioural pharmacology AU - Le Foll, Bernard AU - Wiggins, Marcus AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. blefoll@intra.nida.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 195 EP - 199 VL - 17 IS - 2 SN - 0955-8810, 0955-8810 KW - Hallucinogens KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Male KW - Reward KW - Nicotine -- pharmacology KW - Dronabinol -- pharmacology KW - Hallucinogens -- pharmacology KW - Motor Activity -- drug effects KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67687356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Nicotine+pre-exposure+does+not+potentiate+the+locomotor+or+rewarding+effects+of+Delta-9-tetrahydrocannabinol+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWiggins%2C+Marcus%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2006-03-01&rft.volume=17&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-06 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints. AN - 67670955; 16386343 AB - A retrospective analysis of standard genetic toxicity (genetox) tests, reproductive and developmental toxicity (reprotox) studies, and rodent carcinogenicity bioassays (rcbioassay) was performed to identify the genetox and reprotox endpoints whose results best correlate with rcbioassay observations. A database of 7205 chemicals with genetox (n = 4961), reprotox (n = 2173), and rcbioassay (n = 1442) toxicity data was constructed; 1112 of the chemicals have both genetox and rcbioassay data and 721 chemicals have both reprotox and rcbioassay data. This study differed from previous studies by using conservative weight of evidence criteria to classify chemical carcinogens, data from 63 genetox and reprotox toxicological endpoints, and a new statistical parameter of correlation indicator (CI, the average of specificity and positive predictivity) to identify good surrogate endpoints for predicting carcinogenicity. Among 63 endpoints, results revealed that carcinogenicity was well correlated with certain tests for gene mutation (n = 8), in vivo clastogenicity (n = 2), unscheduled DNA synthesis assay (n = 1), and reprotox (n = 3). The current FDA regulatory battery of four genetox tests used to predict carcinogenicity includes two tests with good correlation (gene mutation in Salmonella and in vivo micronucleus) and two tests with poor correlation (mouse lymphoma gene mutation and in vitro chromosome aberrations) by our criteria. JF - Regulatory toxicology and pharmacology : RTP AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Cimino, Michael C AU - Benz, R Daniel AU - Contrera, Joseph F AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. matthewse@cder.fda.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 83 EP - 96 VL - 44 IS - 2 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Mutagenicity Tests KW - Toxicity Tests, Chronic KW - Carcinogenicity Tests KW - Predictive Value of Tests KW - Reproduction -- drug effects KW - Carcinogens -- classification KW - Databases, Factual KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67670955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+analysis+of+genetic+toxicity%2C+reproductive+and+developmental+toxicity%2C+and+carcinogenicity+data%3A+I.+Identification+of+carcinogens+using+surrogate+endpoints.&rft.au=Matthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BCimino%2C+Michael+C%3BBenz%2C+R+Daniel%3BContrera%2C+Joseph+F&rft.aulast=Matthews&rft.aufirst=Edwin&rft.date=2006-03-01&rft.volume=44&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Allyl sulfur compounds from garlic modulate aberrant crypt formation. AN - 67669952; 16484579 AB - The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided. JF - The Journal of nutrition AU - Ross, Sharon A AU - Finley, John W AU - Milner, John A AD - Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Rockville, MD 20892-7328, USA. rosssha@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 852S EP - 854S VL - 136 IS - 3 Suppl SN - 0022-3166, 0022-3166 KW - Anticarcinogenic Agents KW - 0 KW - Plant Extracts KW - Sulfinic Acids KW - Index Medicus KW - Animals KW - Adenoma -- prevention & control KW - Sulfinic Acids -- therapeutic use KW - Disease Models, Animal KW - Rodentia KW - Anticarcinogenic Agents -- therapeutic use KW - Precancerous Conditions -- prevention & control KW - Plant Extracts -- therapeutic use KW - Garlic KW - Colonic Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67669952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Allyl+sulfur+compounds+from+garlic+modulate+aberrant+crypt+formation.&rft.au=Ross%2C+Sharon+A%3BFinley%2C+John+W%3BMilner%2C+John+A&rft.aulast=Ross&rft.aufirst=Sharon&rft.date=2006-03-01&rft.volume=136&rft.issue=3+Suppl&rft.spage=852S&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Getting to Zero: The Human Side of Mining AN - 58752204; 2007-20603 AB - The material in this Information Circular was presented at the National Institute for Occupational Safety and Health's (NIOSH) open-industry briefing held during the 2004 Northwest Mining Association conference in Spokane, WA. The open-industry briefing discussed results of recently completed and on-going mine safety- and health-related research conducted at NIOSH's Spokane and Pittsburgh Research Laboratories on the human side of mining. Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Mar 2006, 42 pp. AU - Camm, Thomas AU - Cullen, Elaine AU - Jenkins, Mike AU - Mallet, Launa Y1 - 2006/03// PY - 2006 DA - March 2006 EP - 42p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Mining industry - United States KW - Mining industry - Safety measures KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58752204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Camm%2C+Thomas%3BCullen%2C+Elaine%3BJenkins%2C+Mike%3BMallet%2C+Launa&rft.aulast=Camm&rft.aufirst=Thomas&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=42p&rft.isbn=&rft.btitle=Getting+to+Zero%3A+The+Human+Side+of+Mining&rft.title=Getting+to+Zero%3A+The+Human+Side+of+Mining&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2006-112.pdf LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2006 N1 - SuppNotes - DHHS (NIOSH) Publication No. 2006-112 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Provider-specific report cards: a tool for health sector accountability in developing countries AN - 36506382; 3314002 AB - In most health care systems in most countries, providers are not adequately held accountable - by governments, purchasers, provider professional associations or civil society - for the quality of care. One approach to improve provider accountability that is being debated and implemented in a subset of developed countries and a smaller group of developing countries is provider-specific comparative performance reporting. This review discusses universal design options for report cards, summarizes the evidence base, presents developing country examples, reviews challenges and outlines implementation steps. The ultimate aim is to provoke thoughtful debate about if and how comparative performance reporting fits within a developing country's broader framework of strategies to promote quality of care. Reprinted by permission of Oxford University Press JF - Health policy and planning AU - McNamara, Peggy AD - US Agency for Healthcare Research and Quality Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 101 EP - 109 VL - 21 IS - 2 SN - 0268-1080, 0268-1080 KW - Sociology KW - Measurement KW - Customers KW - Development studies KW - Quality control KW - Performance KW - Accountability KW - Developing countries KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36506382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+policy+and+planning&rft.atitle=Provider-specific+report+cards%3A+a+tool+for+health+sector+accountability+in+developing+countries&rft.au=McNamara%2C+Peggy&rft.aulast=McNamara&rft.aufirst=Peggy&rft.date=2006-03-01&rft.volume=21&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Health+policy+and+planning&rft.issn=02681080&rft_id=info:doi/10.1093%2Fheapol%2Fczj009 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 525 9705; 5792 10484; 10524; 3480 2958 12092; 3513; 9390; 3236 3874 556; 7854 DO - http://dx.doi.org/10.1093/heapol/czj009 ER - TY - JOUR T1 - Erratum to ''The use of structure-activity relationship analysis in the food contact notification program'' [Regul. Toxicol. Pharmacol. 42 (2005) 225-235] AN - 21037847; 6722530 JF - Regulatory Toxicology and Pharmacology AU - Bailey, AB AU - Chanderbhan, R AU - Collazo-Braier, N AU - Cheeseman, MA AU - Twaroski, M L AD - Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA, Michelle.Twaroski@cfsan.fda.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 190 VL - 44 IS - 2 SN - 0273-2300, 0273-2300 KW - Aqualine Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21037847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Erratum+to+%27%27The+use+of+structure-activity+relationship+analysis+in+the+food+contact+notification+program%27%27+%5BRegul.+Toxicol.+Pharmacol.+42+%282005%29+225-235%5D&rft.au=Bailey%2C+AB%3BChanderbhan%2C+R%3BCollazo-Braier%2C+N%3BCheeseman%2C+MA%3BTwaroski%2C+M+L&rft.aulast=Bailey&rft.aufirst=AB&rft.date=2006-03-01&rft.volume=44&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2005.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.yrtph.2005.11.004 ER - TY - JOUR T1 - Routine Markerless Gene Replacement in Bacillus anthracis AN - 20975540; 6713626 AB - An improved genetic tool suitable for routine markerless allelic exchange in Bacillus anthracis has been constructed. Its utility was demonstrated by the introduction of insertions, deletions, and missense mutations on the chromosome and plasmid pXO1 of the Sterne strain of B. anthracis. JF - Infection and Immunity AU - Janes, Brian K AU - Stibitz, Scott AD - Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1949 EP - 1953 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 3 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Missense mutation KW - Chromosomes KW - Insertion KW - Chromosome deletion KW - Bacillus anthracis KW - Plasmids KW - G 07320:Bacterial genetics KW - F 06910:Microorganisms & Parasites KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20975540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Routine+Markerless+Gene+Replacement+in+Bacillus+anthracis&rft.au=Janes%2C+Brian+K%3BStibitz%2C+Scott&rft.aulast=Janes&rft.aufirst=Brian&rft.date=2006-03-01&rft.volume=74&rft.issue=3&rft.spage=1949&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; Missense mutation; Insertion; Chromosome deletion; Plasmids; Bacillus anthracis ER - TY - JOUR T1 - The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein AN - 20243679; 6742368 AB - Endogenous retroviral genetic material serves as a reservoir for the generation of retroviral pathogens by recombination between activated endogenous or exogenous infectious agents. Some porcine tissues actively express infectious porcine endogenous retroviruses (PERVs). Of the three classes of PERV characterized to date, two, PERV-A and B, are capable of infecting human cells in vitro, whereas PERV-C cannot. Here, we demonstrate that the PERV-C envelope surface protein (SU) when disassociated from its C-terminus binds human cells. Further, we show that PERV-C binding to human cells is not inhibited in 293 cells productively infected with PERV-A, confirming that the molecule PERV-C interacts with on human cells is distinct from that used by PERV-A. Moreover, we demonstrate that the envelope region encompassing the proline-rich region is required for binding to cells in addition to the putative variable region A (VRA) and B (VRB). The region in the C-terminus of the SU that alters the binding and infectivity properties of PERV-C differs by only nine residues from the analogous region of PERV-A. Caution may be warranted even when a xenotransplantation product is from source pigs that do not express human-tropic viruses, as minimal mutations within PERV-C combined with selection in a human recipient could render PERV-C infectious in humans. JF - Virology AU - Gemeniano, M AU - Mpanju, O AU - Salomon AU - Eiden, M V AU - Wilson, CA AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, HFM-725, Building 29B, Room 2NN12, Bethesda, MD 20892, USA, wilsonc@cber.fda.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 108 EP - 117 VL - 346 IS - 1 SN - 0042-6822, 0042-6822 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Host range KW - C-Terminus KW - Pathogens KW - Porcine endogenous retrovirus KW - Recombination KW - Infectivity KW - Envelopes KW - Retrovirus KW - Envelope protein KW - Xenografts KW - Binding KW - Mutation KW - Variable region KW - W 30940:Products KW - V 22042:Adsorption, penetration & uncoating UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+infectivity+and+host+range+of+the+ecotropic+porcine+endogenous+retrovirus%2C+PERV-C%2C+is+modulated+by+residues+in+the+C-terminal+region+of+its+surface+envelope+protein&rft.au=Gemeniano%2C+M%3BMpanju%2C+O%3BSalomon%3BEiden%2C+M+V%3BWilson%2C+CA&rft.aulast=Gemeniano&rft.aufirst=M&rft.date=2006-03-01&rft.volume=346&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2005.10.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Recombination; Infectivity; Retrovirus; Host range; Envelopes; Envelope protein; C-Terminus; Pathogens; Xenografts; Mutation; Binding; Variable region; Porcine endogenous retrovirus DO - http://dx.doi.org/10.1016/j.virol.2005.10.021 ER - TY - JOUR T1 - The Newborn Drug Development Initiative AN - 19901528; 6715433 AB - The Best Pharmaceuticals for Children Act (BPCA; Pub L 107-109) was enacted in January 2002 and will sunset in October 2007. The BPCA established processes for studying off-patent and on-patent drugs that are used in pediatric population. Although some drugs have been successfully developed for the neonate (eg, surfactant, nitric oxide), drug development for the youngest, least mature, and most vulnerable pediatric patients is generally lacking. Most drugs are empirically administered to newborns once efficacy has been demonstrated in adults and usefulness is suspected or demonstrated in the older pediatric population. Unfortunately, this process undermines the ability to perform the appropriate studies necessary to demonstrate a drug's short- and long-term safety and efficacy and establish appropriate dosing in neonates. The Newborn Drug Development Initiative Workshop I (held March 29-30, 2004) specifically addressed scientific, clinical, and ethical concerns in the development of trials of pediatric therapeutic agents for neonates. Implementation of the BPCA for all pediatric populations will foster collaboration among federal agencies and academic institutions on scientific investigation, clinical-study design, and consideration of the weight of evidence and address ethical issues related to the performance of drug studies. JF - Pediatrics AU - Giacoia, George P AU - Birenbaum, Debra L AU - Sachs, Hari Cheryl AU - Mattison, Donald R AD - Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Division of Pediatric Drug Development, Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - S1 EP - S8 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 3 SN - 0031-4005, 0031-4005 KW - Biotechnology and Bioengineering Abstracts KW - Conferences KW - Pediatrics KW - Ethics KW - Pharmaceuticals KW - Drug development KW - Nitric oxide KW - Neonates KW - Children KW - Drugs KW - Clinical trials KW - Surfactants KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19901528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=The+Newborn+Drug+Development+Initiative&rft.au=Giacoia%2C+George+P%3BBirenbaum%2C+Debra+L%3BSachs%2C+Hari+Cheryl%3BMattison%2C+Donald+R&rft.aulast=Giacoia&rft.aufirst=George&rft.date=2006-03-01&rft.volume=117&rft.issue=3&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Conferences; Pediatrics; Ethics; Pharmaceuticals; Nitric oxide; Drug development; Neonates; Children; Surfactants; Clinical trials; Drugs ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19690714; 7456858 AB - To compare global and regional myocardial infarction (MI) measurements on clinical gadolinium-enhanced magnetic resonance (MR) images using human manual contouring and a computer algorithm previously validated by histopathology, and to study the degree to which visual assessment and human contouring of infarct extent agreed with the computer algorithm. Infarct size in 20 patients was measured by human manual contouring and with an automated feature analysis and combined thresholding (FACT) computer algorithm. Short-axis slices were divided into myocardial sectors for regional analysis. Extent of infarction was also graded visually by consensus of expert readers and compared to human and computer contouring. Despite good correlations (R = 0.93-0.95) between human contouring and the FACT algorithm, human contouring overestimated infarct size by 3.8% of the left ventricle (23.8% of the MI) area (P < 0.001). Human contouring also overestimated the circumferential extent, transmural extent, and extent of infarction within a sector by 7.1%, 18.2%, and 27.9%, respectively (all P < 0.001). Both consensus reading and human contouring overestimated infarct grades compared with the FACT algorithm (P = 0.002 and P < 0.001). Clinically relevant overestimation of MI can occur in visual interpretation and in human manual contouring, particularly with respect to extent of infarction on a regional basis. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Ingkanisorn, WPatricia AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 309 EP - 314 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - myocardial viability KW - magnetic resonance imaging KW - computer aided diagnosis KW - contrast agent KW - gadolinium KW - Ventricle KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+II%3A+Clinical+application+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BIngkanisorn%2C+WPatricia%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20495 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ventricle; Computers; Magnetic resonance imaging; Algorithms; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20495 ER - TY - JOUR T1 - Quantitative myocardial perfusion analysis with a dual-bolus contrast- enhanced first-pass MRI technique in humans AN - 19690396; 7456868 AB - To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual-bolus first-pass perfusion MRI method in humans. Rest and dipyridamole stress perfusion imaging was performed on 10 healthy humans by administering gadolinium contrast using a dual-bolus protocol. Ventricular and myocardial time-signal intensity curves were generated from a series of T1-weighted images and adjusted for surface-coil intensity variations. Corrected signal intensity curves were then fitted using fully quantitative model constrained deconvolution (MCD) to quantify MBF (mL/min/g) and MPR. The results were compared with semiquantitative contrast enhancement ratio (CER) and upslope index (SLP) measurements. MBF (mL/min/g) estimated with MCD averaged 1.02 +/- 0.22 at rest and 3.39 +/- 0.59 for stress with no overlap in measures. MPR was 3.43 +/- 0.71, 1.91 +/- 0.65, and 1.16 +/- 0.19 using MCD, SLP, and CER. Both semiquantitative parameters (SLP and CER) significantly underestimated MPR (P < 0.001) and failed to completely discriminate rest and stress perfusion. Rest and stress MBF (mL/min/g) and MPR estimated by dual-bolus perfusion MRI fit within published ranges. Semiquantitative methods (SLP and CER) significantly underestimated MPR. J. Magn. Reson. Imaging 2006. Published by Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Rhoads, Kenneth L AU - Holly, Jessica E AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 315 EP - 322 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - magnetic resonance imaging KW - myocardial perfusion KW - myocardial blood flow KW - myocardial perfusion reserve KW - contrast agent KW - gadolinium KW - Perfusion KW - Magnetic resonance imaging KW - Gadolinium KW - Stress KW - Dipyridamole KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+perfusion+analysis+with+a+dual-bolus+contrast-+enhanced+first-pass+MRI+technique+in+humans&rft.au=Hsu%2C+Li-Yueh%3BRhoads%2C+Kenneth+L%3BHolly%2C+Jessica+E%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Perfusion; Gadolinium; Magnetic resonance imaging; Stress; Dipyridamole; Models DO - http://dx.doi.org/10.1002/jmri.20502 ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19681796; 7456859 AB - To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference. Delayed enhancement MR was performed in 11 dogs with myocardial infarction (MI) determined by triphenyltetrazolium chloride (TTC). Infarct size on in vivo and ex vivo images was measured by a computer algorithm based on automated feature analysis and combined thresholding (FACT). For comparison, infarct size by human manual contouring and simple intensity thresholding (based on two standard deviation [2SD] and full width at half maximum [FWHM]) were studied. Both in vivo and ex vivo MR infarct size measured by the FACT algorithm correlated well with TTC (R = 0.95-0.97) and showed no significant bias on Bland Altman analysis (P = not significant). Despite similar correlations (R = 0.91-0.97), human manual contouring overestimated in vivo MR infarct size by 5.4% of the left ventricular (LV) area (equivalent to 55.1% of the MI area) vs. TTC (P < 0.001). Infarct size measured by simple intensity thresholdings was less accurate than the proposed algorithm (P < 0.001 and P = 0.007). The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Natanzon, Alex AU - Kellman, Peter AU - Hirsch, Glenn A AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 298 EP - 308 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - magnetic resonance imaging KW - computer algorithm KW - image processing KW - expert system KW - contrast agent KW - gadolinium KW - Standard deviation KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Triphenyltetrazolium chloride KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+I%3A+Animal+validation+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BNatanzon%2C+Alex%3BKellman%2C+Peter%3BHirsch%2C+Glenn+A%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standard deviation; Computers; Magnetic resonance imaging; Algorithms; Triphenyltetrazolium chloride; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20496 ER - TY - JOUR T1 - Bombesin/Gastrin-Releasing Peptide Receptor Antagonists Increase the Ability of Histone Deacetylase Inhibitors to Reduce Lung Cancer Proliferation AN - 19648772; 7393109 AB - The effects of a bombesin/gastrin releasing peptide (BB/GRP) receptor antagonist, PD176252, and histone deacetylase (HDAC) Inhibitor, MS-275, were investigated on human lung cancer cell lines. Using the MTT assay, PD176252 and MS-275 inhibited the proliferation of NCI-H1299 cells with IC sub(50) values of 7 and 5 mu g/mL, respectively. Using MS-275 and PD176252 together, the ability to inhibit lung cancer cellular growth increased significantly. The combination index for MS-275 and PD176252 was <0.2, indicating that the compounds are highly synergistic in inhibiting lung cancer cellular growth. Also, MS-275 and PD176252 together strongly inhibited the cional growth of NCI-H345 or NCI-H1299 cells. MS-275 had little effect on the expression of lung cancer cellular GRP or GRP receptors, but increased expression of transforming growth factor- beta receptor II (TGF- beta RII). These results indicate that GRP receptor antagonists may potentiate the action of histone deacetylase inhibitors on lung cancer cellular proliferation by increasing expression of tumor suppressor genes. JF - Journal of Molecular Neuroscience AU - Moody, T W AU - Nakagawa, T AU - Kang, Y AU - Jakowlew, S AU - Chan, D AU - Jensen, R T AD - Department of Health and Human Services, Office of the Director, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 231 EP - 238 VL - 28 IS - 3 SN - 0895-8696, 0895-8696 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gastrin-releasing peptide KW - Histone deacetylase KW - Tumor suppressor genes KW - Tumor cell lines KW - Transforming growth factor- beta KW - Bombesin KW - Gastrin KW - transforming growth factor- beta receptors KW - Cell proliferation KW - Antagonists KW - Lung cancer KW - N3 11007:Neurobiology KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19648772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Neuroscience&rft.atitle=Bombesin%2FGastrin-Releasing+Peptide+Receptor+Antagonists+Increase+the+Ability+of+Histone+Deacetylase+Inhibitors+to+Reduce+Lung+Cancer+Proliferation&rft.au=Moody%2C+T+W%3BNakagawa%2C+T%3BKang%2C+Y%3BJakowlew%2C+S%3BChan%2C+D%3BJensen%2C+R+T&rft.aulast=Moody&rft.aufirst=T&rft.date=2006-03-01&rft.volume=28&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Neuroscience&rft.issn=08958696&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gastrin-releasing peptide; Tumor suppressor genes; Histone deacetylase; Tumor cell lines; Transforming growth factor- beta; Gastrin; Bombesin; transforming growth factor- beta receptors; Cell proliferation; Antagonists; Lung cancer ER - TY - JOUR T1 - Estimation of the transmissibility of anti-vibration gloves when used with specific tools AN - 19502217; 7183612 AB - Anti-vibration gloves are increasingly being used as personal protective equipment to help reduce the hazards of hand-transmitted vibration. A vibration transfer function method for estimating the tool-specific performance of anti-vibration gloves has been proposed to help select appropriate gloves for particular tools and to assess the potential risks posed by tool vibration. This study evaluates the validity of the method by comparing the predicted vibration transmissibility with the measured value. Two typical vibration-attenuating gloves (air-bladder and viscoelastic material gloves) were used in the study. Two series of experiments were performed for the evaluation. In the first series, the isolation efficiency of selected anti-vibration gloves was evaluated in the laboratory under synthesized handle vibration spectra of six different tools. The second series of tests involved the measurement of the glove transmissibility, while operating two different pneumatic chipping hammers. The results of the study show reasonably good agreements between the predicted and measured acceleration transmissibility values of the candidate gloves. It is thus concluded that the transfer function method provides a reasonably good estimate of vibration attenuation performance of gloves for specific tools. JF - Noise and Vibration in Industry AU - Dong, R G AU - Welcome, DE AU - McDowell, T W AU - Rakheja, S AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 45 EP - 58 VL - 20 IS - 2 SN - 0950-8163, 0950-8163 KW - Health & Safety Science Abstracts KW - Protective clothing KW - Vibration KW - gloves KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19502217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Vibration+in+Industry&rft.atitle=Estimation+of+the+transmissibility+of+anti-vibration+gloves+when+used+with+specific+tools&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BMcDowell%2C+T+W%3BRakheja%2C+S&rft.aulast=Dong&rft.aufirst=R&rft.date=2006-03-01&rft.volume=20&rft.issue=2&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Noise+and+Vibration+in+Industry&rft.issn=09508163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protective clothing; Vibration; gloves; Occupational exposure ER - TY - JOUR T1 - Effects of early and later family violence on children's behavior problems and depression: A longitudinal, multi-informant perspective AN - 19455695; 7639264 AB - Objectives To examine the effects of different forms of family violence at two developmental stages by assessing a sample of 110 Israeli children, drawn from the case files of Israeli family service agencies, studied longitudinally in both middle childhood and adolescence. Methods Information about the children's adjustment was obtained from parents, teachers, and the children themselves when the children averaged 10.6 and 15.9 years of age using the Child Behavior Checklist (CBCL), Teacher Report Form (TRF), Youth Self-Report (YSR), and Children's Depression Inventory (CDI). Information about the history of family violence was obtained from the mothers, fathers, children, and social workers. Results The results paint a mixed picture of the effects of family violence on children and adolescents. The relationship between concurrent behavior problems and abuse group varied by informant and study phase, although they were strongest when children were the informants. Predictions regarding the relationship between early abuse and later adjustment were only partially confirmed. Different informants did not agree about which groups of children were most adversely affected, there was little stability over time in the pattern of reported effects, and children were more likely than other informants to report levels of maladjustment that varied depending on recent or concurrent exposure to family violence. Many families changed their abuse status over time, and children who were new victims at follow-up had the most internalizing problems. Girls were found to be at more risk for internalizing and externalizing behavior problems than boys. Conclusions Multiple informants are necessary to evaluate and assess the effects of family violence on children's behavior. Younger children may be more susceptible to the effects of family violence than older children, but problems manifest by some children may not carry over to adolescence. Changes in family and parenting practices, as well as in children's capacity to appraise and cope with family violence may help mitigate the adverse effects of family violence. JF - Child Abuse & Neglect AU - Sternberg, Kathleen J AU - Lamb, Michael E AU - Guterman, Eva AU - Abbott, Craig B AD - National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, United States Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 283 EP - 306 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 3 SN - 0145-2134, 0145-2134 KW - Risk Abstracts KW - Family violence KW - Child abuse KW - Internalizing behavior problems KW - Externalizing behavior problems KW - Maladjustment KW - Historical account KW - Behavior KW - developmental stages KW - Children KW - Violence KW - depression KW - Side effects KW - Adolescents KW - Paints KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19455695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+%26+Neglect&rft.atitle=Effects+of+early+and+later+family+violence+on+children%27s+behavior+problems+and+depression%3A+A+longitudinal%2C+multi-informant+perspective&rft.au=Sternberg%2C+Kathleen+J%3BLamb%2C+Michael+E%3BGuterman%2C+Eva%3BAbbott%2C+Craig+B&rft.aulast=Sternberg&rft.aufirst=Kathleen&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+%26+Neglect&rft.issn=01452134&rft_id=info:doi/10.1016%2Fj.chiabu.2005.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Historical account; Behavior; developmental stages; Children; depression; Violence; Adolescents; Side effects; Paints DO - http://dx.doi.org/10.1016/j.chiabu.2005.10.008 ER - TY - JOUR T1 - Assessing Self-Renewal and Differentiation in Human Embryonic Stem Cell Lines AN - 19438241; 6752835 AB - Like other cell populations, undifferentiated human embryonic stem cells (hESCs) express a characteristic set of proteins and mRNA that is unique to the cells regardless of culture conditions, number of passages, and methods of propagation. We sought to identify a small set of markers that would serve as a reliable indicator of the balance of undifferentiated and differentiated cells in hESC populations. Markers of undifferentiated cells should be rapidly downregulated as the cells differentiate to form embryoid bodies (EBs), whereas markers that are absent or low during the undifferentiated state but that are induced as hESCs differentiate could be used to assess the presence of differentiated cells in the cultures. In this paper, we describe a list of markers that reliably distinguish undifferentiated and differentiated cells. An initial list of approximately 150 genes was generated by scanning published massively parallel signature sequencing, expressed sequence tag scan, and microarray datasets. From this list, a subset of 109 genes was selected that included 55 candidate markers of undifferentiated cells, 46 markers of hESC derivatives, four germ cell markers, and four trophoblast markers. Expression of these candidate marker genes was analyzed in undifferentiated hESCs and differentiating EB populations in four different lines by immunocytochemistry, reverse transcription-polymer-ase chain reaction (RT-PCR), microarray analysis, and quantitative RT-PCR (qPCR). We show that qPCR, with as few as 12 selected genes, can reliably distinguish differentiated cells from undifferentiated hESC populations. JF - Stem Cells AU - Cai, Jingli AU - Chen, Jia AU - Liu, Ying AU - Miura, Takumi AU - Luo, Yongquan AU - Loring, Jeanne F AU - Freed, William J AU - Rao, Mahendra S AU - Zeng, Xianmin AD - Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services (DHHS), Baltimore, Maryland, USA. Cellular Neurobiology Branch, National Institute on Drug Abuse, DHHS, Baltimore, Maryland, USA. Program in Stem Cells and Regeneration, The Burnham Institute, La Jolla, California, USA. Invitrogen, Carlsbad, California, USA. Buck Insititute, Novato, California, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 516 EP - 530 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunocytochemistry KW - Differentiation KW - Stem cells KW - Embryo cells KW - Scanning KW - Germ cells KW - Polymerase chain reaction KW - Trophoblasts KW - Cell culture KW - DNA microarrays KW - expressed sequence tags KW - W 30905:Medical Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessing+Self-Renewal+and+Differentiation+in+Human+Embryonic+Stem+Cell+Lines&rft.au=Cai%2C+Jingli%3BChen%2C+Jia%3BLiu%2C+Ying%3BMiura%2C+Takumi%3BLuo%2C+Yongquan%3BLoring%2C+Jeanne+F%3BFreed%2C+William+J%3BRao%2C+Mahendra+S%3BZeng%2C+Xianmin&rft.aulast=Cai&rft.aufirst=Jingli&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Immunocytochemistry; Stem cells; Scanning; Embryo cells; Germ cells; Trophoblasts; Polymerase chain reaction; Cell culture; expressed sequence tags; DNA microarrays ER - TY - JOUR T1 - Myeloid differentiation factor-88 (MyD88) is essential for control of primary in vivo Francisella tularensis LVS infection, but not for control of intramacrophage bacterial replication AN - 17166650; 6822580 AB - The means by which Francisella tularensis, the causative agent of tularemia, are recognized by mammalian immune systems are poorly understood. Here we wished to explore the contribution of the MyD88/Toll-like receptor signaling pathway in initiating murine responses to F. tularensis Live Vaccine Strain (LVS). MyD88 knockout (KO) mice, but not TLR2-, TLR4- or TLR9- deficient mice, rapidly succumbed following in vivo bacterial infection via the intradermal route even with a very low dose of LVS (5 x 10) that was 100,000- fold less than the LD sub(50) of normal wild-type (WT) mice. By day 5 after LVS infection, bacterial organ burdens were 5-6 logs higher in MyD88 knockout mice; further, unlike infected WT mice, levels of interferon- gamma in the sera of LVS- infected MyD88 KO were undetectable. An in vitro culture system was used to assess the ability of bone marrow macrophages derived from either KO or WT mice to support bacterial growth, or to control intracellular bacterial replication when co-cultured with immune lymphocytes. In this assay, bacterial replication was similar in macrophages derived from either WT or any of the TLR KO mice. Bacterial growth was controlled in co-cultures containing macrophages from MyD88 KO mice or TLR KO mice as well as in co-cultures containing immune WT splenic lymphocytes and WT macrophages. Further, MyD88-deficient LVS-immune splenocytes controlled intracellular growth comparably to those from normal mice. Thus MyD88 is essential for innate host resistance to LVS infection, but is not required for macrophage control of intracellular bacterial growth. JF - Microbes and Infection AU - Collazo, Carmen M AU - Sher, Alan AU - Meierovics, Anda I AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, karen.elkins@fda.hhs.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 779 EP - 790 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 8 IS - 3 SN - 1286-4579, 1286-4579 KW - mice KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Francisella tularensis KW - Immunology KW - Bacterial infections KW - Toll-like receptors KW - Macrophages KW - Bacteria KW - gamma -Interferon KW - Replication KW - MyD88 protein KW - Immune system KW - Bone marrow KW - Spleen KW - Lymphocytes KW - Infection KW - Differentiation KW - Splenocytes KW - Tularemia KW - Vaccines KW - Signal transduction KW - J 02833:Immune response and immune mechanisms KW - A 01390:Forestry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17166650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Myeloid+differentiation+factor-88+%28MyD88%29+is+essential+for+control+of+primary+in+vivo+Francisella+tularensis+LVS+infection%2C+but+not+for+control+of+intramacrophage+bacterial+replication&rft.au=Collazo%2C+Carmen+M%3BSher%2C+Alan%3BMeierovics%2C+Anda+I%3BElkins%2C+Karen+L&rft.aulast=Collazo&rft.aufirst=Carmen&rft.date=2006-03-01&rft.volume=8&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2005.09.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; MyD88 protein; Replication; Immune system; Bone marrow; Spleen; Lymphocytes; Infection; Splenocytes; Differentiation; Tularemia; Vaccines; Toll-like receptors; Signal transduction; Bacteria; Francisella tularensis DO - http://dx.doi.org/10.1016/j.micinf.2005.09.014 ER - TY - JOUR T1 - Assessing Weight-Related Quality of Life in Adolescents AN - 17147578; 6814659 AB - OBJECTIVE: The development of a new weight-related measure to assess quality of life in adolescents [Impact of Weight on Quality of Life (IWQOL)-Kids] is described. RESEARCH METHODS AND PROCEDURES: Using a literature search, clinical experience, and consultation with pediatric clinicians, 73 items were developed, pilot tested, and administered to 642 participants, 11 to 19 years old, recruited from weight loss programs/studies and community samples (mean z-BMI, 1.5; range, -1.2 to 3.4; mean age, 14.0; 60% female; 56% white). Participants completed the 73 items and the Pediatric Quality of Life Inventory and were weighed and measured. RESULTS: Four factors (27 items) were identified (physical comfort, body esteem, social life, and family relations), accounting for 71% of the variance. The IWQOL-Kids demonstrated excellent psychometric properties. Internal consistency coefficients ranged from 0.88 to 0.95 for scales and equaled 0.96 for total score. Convergent validity was demonstrated with strong correlations between IWQOL-Kids total score and the Pediatric Quality of Life Inventory (r = 0.76, p < 0.0001). Significant differences were found across BMI groups and between clinical and community samples, supporting the sensitivity of this measure. Participants in a weight loss camp demonstrated improved IWQOL-Kids scores, suggesting responsiveness of the IWQOL-Kids to weight loss/social support intervention. DISCUSSION: The present study provides preliminary evidence regarding the psychometric properties of the IWQOL-Kids, a weight-related quality of life measure for adolescents. Given the rise of obesity in youth, the development of a reliable and valid weight-related measure of quality of life is timely. JF - Obesity Research AU - Kolotkin, Ronette L AU - Zeller, Meg AU - Modi, Avani C AU - Samsa, Gregory P AU - Polanichka Quinlan, Nicole AU - Yanovski, Jack A AU - Bell, Stephen K AU - Maahs, David M AU - Gonzales de Serna, Daniela AU - Roehrig, Helmut R AD - Obesity and Quality of Life Consulting, Durham, North Carolina. Community and Family Medicine, Center for Clinical Health Policy Research, and. Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina. Division of Psychology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio. Department of Psychology, Social and Health Sciences, Duke University, Durham, North Carolina. Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Children's Health System, Children's Behavioral Health, Birmingham, Alabama. Barbara Davis Center for Diabetes, University of Colorado Health Sciences Center, Denver, Colorado. Department of Internal Medicine, University Hospital, Albuquerque, New Mexico Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 448 EP - 457 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 3 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Camps KW - Obesity KW - Measurement KW - Programs KW - Weight control KW - Pediatrics KW - Adolescence KW - Consultation KW - Validity KW - scoring KW - Lifestyle KW - Experience KW - Literature reviews KW - Social support KW - Family KW - Body concept KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Assessing+Weight-Related+Quality+of+Life+in+Adolescents&rft.au=Kolotkin%2C+Ronette+L%3BZeller%2C+Meg%3BModi%2C+Avani+C%3BSamsa%2C+Gregory+P%3BPolanichka+Quinlan%2C+Nicole%3BYanovski%2C+Jack+A%3BBell%2C+Stephen+K%3BMaahs%2C+David+M%3BGonzales+de+Serna%2C+Daniela%3BRoehrig%2C+Helmut+R&rft.aulast=Kolotkin&rft.aufirst=Ronette&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Camps; Measurement; Obesity; Programs; Weight control; Pediatrics; Consultation; Adolescence; Validity; Lifestyle; scoring; Experience; Social support; Literature reviews; Family; Body concept; Youth ER - TY - JOUR T1 - Human Immunodeficiency Virus (HIV) Vaccine Trials: a Novel Assay for Differential Diagnosis of HIV Infections in the Face of Vaccine-Generated Antibodies AN - 17087780; 6714736 AB - All current human immunodeficiency virus (HIV) vaccine candidates contain multiple viral components and elicit antibodies that react positively in licensed HIV diagnostic tests, which contain similar viral products. Thus, vaccine trial participants could be falsely diagnosed as infected with HIV. Additionally, uninfected, seropositive vaccinees may encounter long-term social and economic harms. Moreover, this also interferes with early detection of true HIV infections during preventive HIV vaccine trials. An HIV-seropositive test result among uninfected vaccine trial participants is a major public health concern for volunteers who want to participate in future HIV vaccine trials. Based on the increased number of HIV vaccines being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Using a whole-HIV-genome phage display library, we identified conserved sequences in Env-gp41 and Gag-p6 which are recognized soon after infection, do not contain protective epitopes, and are not part of most current HIV vaccines. We established a new HIV serodetection assay based on these peptides. To date, this assay, termed HIV-SELECTEST, demonstrates >99% specificity and sensitivity. Importantly, in testing of plasma samples from multiple HIV vaccine trials, uninfected trial participants scored negative, while all intercurrent infections were detected within 1 to 3 months of HIV infection. The new HIV-SELECTEST is a simple but robust diagnostic tool for easy implementation in HIV vaccine trials and blood banks worldwide. JF - Journal of Virology AU - Khurana, Surender AU - Needham, James AU - Mathieson, Bonnie AU - Rodriguez-Chavez, Isaac R AU - Catanzaro, Andrew T AU - Bailer, Robert T AU - Kim, Jerome AU - Polonis, Vicky AU - Cooper, David A AU - Guerin, Jan AU - Peterson, Michael L AU - Gurwith, Marc AU - Nguyen, Nga AU - Graham, Barney S AU - Golding, Hana AD - Division of Viral Products. Core Facility, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, Maryland 20892. Office of AIDS Research, NIH, Bethesda, Maryland 20892. Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. U.S. Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), APO AP 96546. U.S. Military HIV Research Program, Rockville, Maryland 20850. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia 2010. VaxGen, Inc., Brisbane, California 94005 Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 2092 EP - 2099 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 5 SN - 0022-538X, 0022-538X KW - HIV KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Public health KW - Economics KW - Epitopes KW - Phage display KW - Blood KW - Antibodies KW - Differential diagnosis KW - Human immunodeficiency virus KW - Vaccines KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - V 22003:AIDS: Immunological aspects KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Human+Immunodeficiency+Virus+%28HIV%29+Vaccine+Trials%3A+a+Novel+Assay+for+Differential+Diagnosis+of+HIV+Infections+in+the+Face+of+Vaccine-Generated+Antibodies&rft.au=Khurana%2C+Surender%3BNeedham%2C+James%3BMathieson%2C+Bonnie%3BRodriguez-Chavez%2C+Isaac+R%3BCatanzaro%2C+Andrew+T%3BBailer%2C+Robert+T%3BKim%2C+Jerome%3BPolonis%2C+Vicky%3BCooper%2C+David+A%3BGuerin%2C+Jan%3BPeterson%2C+Michael+L%3BGurwith%2C+Marc%3BNguyen%2C+Nga%3BGraham%2C+Barney+S%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2006-03-01&rft.volume=80&rft.issue=5&rft.spage=2092&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Vaccines; Antibodies; Public health; Phage display; Blood; Economics; Differential diagnosis; Epitopes ER - TY - JOUR T1 - Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation AN - 17084050; 6718067 AB - Our laboratory has previously reported results from a rat silica inhalation study which determined that, even after silica exposure ended, pulmonary inflammation and damage progressed with subsequent fibrosis development. In the present study, the relationship between silica exposure, nitric oxide (NO) and reactive oxygen species (ROS) production, and the resultant pulmonary damage is investigated in this model. Rats were exposed to silica (15 mg/m super(3), 6 h/day) for either 20, 40, or 60 days. A portion of the rats from each exposure were sacrificed at 0 days postexposure, while another portion was maintained without further exposure for 36 days to examine recovery or progression. The major findings of this study are: (1) silica-exposed rat lungs were in a state of oxidative stress, the severity of which increased during the postexposure period, (2) silica-exposed rats had significant increase in lung NO production which increased in magnitude during the postexposure period, and (3) the presence of silica particle(s) in an alveolar macrophage (AM) was highly associated with inducible nitric oxide synthase (iNOS) protein. These data indicate that, even after silica exposure has ended, and despite declining silica lung burden, silica-induced pulmonary NO and ROS production increases, thus producing a more severe oxidative stress. A quantitative association between silica and expression of iNOS protein in AMs was also determined, which adds to our previous observation that iNOS and NO-mediated damage are associated anatomically with silica-induced pathological lesions. Future studies will be needed to determine whether the progressive oxidative stress, and iNOS activation and NO production, is a direct result of silica lung burden or a consequence of silica-induced biochemical mediators. JF - Toxicological Sciences AU - Porter, Dale W AU - Millecchia, Lyndell L AU - Willard, Patsy AU - Robinson, Victor A AU - Ramsey, Dawn AU - McLaurin, Jeffery AU - Khan, Amir AU - Brumbaugh, Kurt AU - Beighley, Christoper M AU - Teass, Alexander AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505 and Division of Applied Research and Technology, Cincinnati, Ohio 45226 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 188 EP - 197 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 90 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Nitric-oxide synthase KW - Inhalation KW - Macrophages KW - Silica KW - Reactive oxygen species KW - Lung KW - Oxidative stress KW - Fibrosis KW - Nitric oxide KW - Models KW - Inflammation KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17084050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Nitric+Oxide+and+Reactive+Oxygen+Species+Production+Causes+Progressive+Damage+in+Rats+after+Cessation+of+Silica+Inhalation&rft.au=Porter%2C+Dale+W%3BMillecchia%2C+Lyndell+L%3BWillard%2C+Patsy%3BRobinson%2C+Victor+A%3BRamsey%2C+Dawn%3BMcLaurin%2C+Jeffery%3BKhan%2C+Amir%3BBrumbaugh%2C+Kurt%3BBeighley%2C+Christoper+M%3BTeass%2C+Alexander%3BCastranova%2C+Vincent&rft.aulast=Porter&rft.aufirst=Dale&rft.date=2006-03-01&rft.volume=90&rft.issue=1&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Inhalation; Nitric-oxide synthase; Silica; Reactive oxygen species; Fibrosis; Oxidative stress; Lung; Nitric oxide; Inflammation; Models ER - TY - JOUR T1 - Gene Products Required for De Novo Synthesis of Polysialic Acid in Escherichia coli K1 AN - 17083253; 6713675 AB - Escherichia coli K1 is responsible for 80% of E. coli neonatal meningitis and is a common pathogen in urinary tract infections. Bacteria of this serotype are encapsulated with the alpha (2-8)-polysialic acid NeuNAc( alpha 2-8), common to several bacterial pathogens. The gene cluster encoding the pathway for synthesis of this polymer is organized into three regions: (i) kpsSCUDEF, (ii) neuDBACES, and (iii) kpsMT. The K1 polysialyltransferase, NeuS, cannot synthesize polysialic acid de novo without other products of the gene cluster. Membranes isolated from strains having the entire K1 gene cluster can synthesize polysialic acid de novo. We designed a series of plasmid constructs containing fragments of regions 1 and 2 in two compatible vectors to determine the minimum number of gene products required for de novo synthesis of the polysialic acid from CMP-NeuNAc in K1 E. coli. We measured the ability of the various combinations of region 1 and 2 fragments to restore polysialyltransferase activity in vitro in the absence of exogenously added polysaccharide acceptor. The products of region 2 genes neuDBACES alone were not sufficient to support de novo synthesis of polysialic acid in vitro. Only membrane fractions harboring NeuES and KpsCS could form sialic polymer in the absence of exogenous acceptor at the concentrations formed by wild-type E. coli K1 membranes. Membrane fractions harboring NeuES and KpsC together could form small quantities of the sialic polymer de novo. JF - Journal of Bacteriology AU - Andreishcheva, Ekaterina N AU - Vann, Willie F AD - Laboratory of Bacterial Toxins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1786 EP - 1797 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 5 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - ErbB-2 protein KW - Serotypes KW - Urinary tract KW - Pathogens KW - Infection KW - Polysaccharides KW - Plasmids KW - Meningitis KW - double prime K1 gene KW - polysialyltransferase KW - Gene clusters KW - Escherichia coli KW - Neonates KW - polysialic acid KW - G 07203:Plasmids KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17083253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Gene+Products+Required+for+De+Novo+Synthesis+of+Polysialic+Acid+in+Escherichia+coli+K1&rft.au=Andreishcheva%2C+Ekaterina+N%3BVann%2C+Willie+F&rft.aulast=Andreishcheva&rft.aufirst=Ekaterina&rft.date=2006-03-01&rft.volume=188&rft.issue=5&rft.spage=1786&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serotypes; ErbB-2 protein; Pathogens; Urinary tract; Plasmids; Polysaccharides; Infection; Meningitis; polysialyltransferase; double prime K1 gene; Gene clusters; polysialic acid; Neonates; Escherichia coli ER - TY - JOUR T1 - Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176 AN - 17080414; 6721736 AB - Analyses of invasive enteric bacteria (e.g. Shigella, Salmonella, Listeria, and Campylobacter) have shown that these pathogens initiate orchestrated signal transduction cascades in host cells leading to host cytoskeletal rearrangements that result in bacterial uptake. This current study was specifically aimed at examining the involvement of host membrane caveolae and certain protein kinases in epithelial cell invasion by C. jejuni strain 81-176, for which we have previously characterized the kinetics of entry and a unique microtubule-dependent mechanism of internalization. Utilizing in vitro cultured cell invasion assays with a gentamicin-kill step, disruption of membrane caveolae by pretreatment of INT407 cell monolayers with filipin III reduced C. jejuni 81-176 entry by >95%. Strain 81-176 uptake into INT407 cells was markedly inhibited by monolayer pretreatment with the protein kinase inhibitors genistein and staurosporine, or specific inhibitors of PI 3-kinase, wortmannin and LY294002. Western blot analysis using monoclonal anti-protein tyrosine phosphorylation antibody revealed distinctive changes during invasion in phosphorylation of at least nine proteins. Further inhibitor studies indicated that heterotrimeric G proteins, plus ERK and p38 MAP kinase activation are also involved in C. jejuni 81-176 invasion. These results suggest that C. jejuni 81-176 interact at host cell surface membrane caveolae with G protein-coupled receptors, which presumably trigger G-proteins and kinases to activate host proteins including PI 3-kinase and MAP kinases, that appear to be intimately involved in the events controlling 81-176 internalization. JF - Microbial Pathogenesis AU - Hu, L AU - McDaniel, J P AU - Kopecko, D J AD - Center for Biologics Evaluation and Research, FDA, NIH Campus Building 29/420, 29 Lincoln Drive, Bethesda, MD 20892, USA, kopecko@cber.fda.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 91 EP - 100 VL - 40 IS - 3 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Epithelial cells KW - Cell surface KW - MAP kinase KW - double prime G protein-coupled receptors KW - Guanine nucleotide-binding protein KW - Tyrosine KW - Shigella KW - Pathogens KW - Listeria KW - protein kinase inhibitors KW - Cytoskeleton KW - Extracellular signal-regulated kinase KW - Antibodies KW - 1-Phosphatidylinositol 3-kinase KW - Phosphorylation KW - Caveolae KW - Campylobacter jejuni KW - Kinetics KW - Staurosporine KW - Salmonella KW - Genistein KW - Wortmannin KW - Signal transduction KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17080414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Signal+transduction+events+involved+in+human+epithelial+cell+invasion+by+Campylobacter+jejuni+81-176&rft.au=Hu%2C+L%3BMcDaniel%2C+J+P%3BKopecko%2C+D+J&rft.aulast=Hu&rft.aufirst=L&rft.date=2006-03-01&rft.volume=40&rft.issue=3&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2005.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Epithelial cells; MAP kinase; double prime G protein-coupled receptors; Tyrosine; Guanine nucleotide-binding protein; Pathogens; Cytoskeleton; protein kinase inhibitors; Extracellular signal-regulated kinase; 1-Phosphatidylinositol 3-kinase; Antibodies; Phosphorylation; Caveolae; Kinetics; Staurosporine; Genistein; Signal transduction; Wortmannin; Campylobacter jejuni; Shigella; Salmonella; Listeria DO - http://dx.doi.org/10.1016/j.micpath.2005.11.004 ER - TY - JOUR T1 - Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen. AN - 67754038; 16458862 AB - Fluoro-Ruby (FR) was injected into the substantia nigra (SNc) to label dopaminergic axons and terminals in the caudate putamen (CPu) of rats 7 days prior to a neurotoxic d-amphetamine (AMPH) exposure. Three days after AMPH exposure, a massive loss in the TH immunoreactive (TH(+)) axons and terminals was seen in the CPu. The FR-labeled (FR(+)) axons and terminals in the CPu were greatly diminished with those remaining being enlarged or swollen after AMPH. Fluoro-Jade C (FJ-C) labeling was used to verify AMPH-induced axonal and terminal degeneration. This study demonstrates that fluorescent anterograde tract tracers can be used to show the subsequent axonal and terminal degeneration after systemic exposures to toxins and provides direct evidence that CPu axons and terminals from SNc dopaminergic neurons can be destroyed after neurotoxic exposure to AMPH. JF - Brain research AU - Bowyer, John F AU - Schmued, Larry C AD - Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, Jefferson, AR 72079-9502, USA. jbowyer@nctr.fda.gov Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 SP - 236 EP - 239 VL - 1075 IS - 1 SN - 0006-8993, 0006-8993 KW - Dextrans KW - 0 KW - Fluorescent Dyes KW - Fluoro-Ruby KW - Neurotoxins KW - Rhodamines KW - Amphetamine KW - CK833KGX7E KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Rats, Sprague-Dawley KW - Neurotoxins -- toxicity KW - Male KW - Putamen -- pathology KW - Axons -- drug effects KW - Amphetamine -- toxicity KW - Caudate Nucleus -- pathology KW - Dopamine -- physiology KW - Caudate Nucleus -- drug effects KW - Putamen -- drug effects KW - Axons -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67754038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Fluoro-Ruby+labeling+prior+to+an+amphetamine+neurotoxic+insult+shows+a+definitive+massive+loss+of+dopaminergic+terminals+and+axons+in+the+caudate-putamen.&rft.au=Bowyer%2C+John+F%3BSchmued%2C+Larry+C&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2006-02-23&rft.volume=1075&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-31 N1 - Date created - 2006-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Who's Driving the Car: How Child Welfare Consumers Reach Mental Health Providers T2 - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AN - 39953807; 4149900 JF - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AU - Fedoravicius, Nicole R AU - McMillen, Curtis AU - Rowe, Jill AU - Kagotho, Njeri Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 KW - Consumers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39953807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.atitle=Who%27s+Driving+the+Car%3A+How+Child+Welfare+Consumers+Reach+Mental+Health+Providers&rft.au=Fedoravicius%2C+Nicole+R%3BMcMillen%2C+Curtis%3BRowe%2C+Jill%3BKagotho%2C+Njeri&rft.aulast=Fedoravicius&rft.aufirst=Nicole&rft.date=2006-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/rtcconference/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Too much, Too Many, Too Often: Professionals? Views of Psychotropic Medications for Child Welfare System Consumers T2 - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AN - 39928281; 4149864 JF - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AU - McMillen, Curtis AU - Fedoravicius, Nicole AU - Rowe, Jill AU - Kagotho, Njeri Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 KW - Consumers KW - Experts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.atitle=Too+much%2C+Too+Many%2C+Too+Often%3A+Professionals%3F+Views+of+Psychotropic+Medications+for+Child+Welfare+System+Consumers&rft.au=McMillen%2C+Curtis%3BFedoravicius%2C+Nicole%3BRowe%2C+Jill%3BKagotho%2C+Njeri&rft.aulast=McMillen&rft.aufirst=Curtis&rft.date=2006-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/rtcconference/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - School Functioning for Children with Serious Emotional Disturbance Enrolled in a Multisite Wraparound Program T2 - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AN - 39922427; 4149996 JF - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AU - Taub, Jennifer AU - Pearrow, Melissa AU - Shields, Jessica Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 KW - Children KW - Schools KW - Emotions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.atitle=School+Functioning+for+Children+with+Serious+Emotional+Disturbance+Enrolled+in+a+Multisite+Wraparound+Program&rft.au=Taub%2C+Jennifer%3BPearrow%2C+Melissa%3BShields%2C+Jessica&rft.aulast=Taub&rft.aufirst=Jennifer&rft.date=2006-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/rtcconference/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Psychotropic Medications During the Transition Out of Foster Care T2 - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AN - 39922047; 4149910 DE: JF - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AU - McMillen, Curtis AU - Lee, Bethany Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.atitle=Use+of+Psychotropic+Medications+During+the+Transition+Out+of+Foster+Care&rft.au=McMillen%2C+Curtis%3BLee%2C+Bethany&rft.aulast=McMillen&rft.aufirst=Curtis&rft.date=2006-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/rtcconference/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationships between Fidelity and Outcomes in a Multi-Site Wraparound Initiative T2 - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AN - 39872502; 4149972 JF - 19th Annual Research Conference A System of Care for Childrens Mental Health: Expanding Th e Research Base AU - Taub, Jennifer Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 KW - Fidelity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.atitle=Relationships+between+Fidelity+and+Outcomes+in+a+Multi-Site+Wraparound+Initiative&rft.au=Taub%2C+Jennifer&rft.aulast=Taub&rft.aufirst=Jennifer&rft.date=2006-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Research+Conference+A+System+of+Care+for+Childrens+Mental+Health%3A+Expanding+Th+e+Research+Base&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/rtcconference/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Recruitment and activation of PLC[gamma]1 in T cells: a new insight into old domains AN - 195267872; 16467851 AB - Engagement of the T-cell antigen receptor leads to recruitment of phospholipase Cgamma1 (PLCgamma1) to the LAT-nucleated signaling complex and to PLCgamma1 activation in a tyrosine phosphorylation-dependent manner. The mechanism of PLCgamma1 recruitment and the role of PLCgamma1 Src homology (SH) domains in this process remain incompletely understood. Using a combination of biochemical methods and real-time fluorescent imaging, we show here that the N-terminal SH2 domain of PLCgamma1 is necessary but not sufficient for its recruitment. Either the SH3 or C-terminal SH2 domain of PLCgamma1, with the participation of Vav1, c-Cbl and Slp76, are required to stabilize PLCgamma1 recruitment. All three PLCgamma1 SH domains are required for phosphorylation of PLCgamma1 Y783, which is critical for enzyme activation. These novel findings entailed revision of the currently accepted model of PLCgamma1 recruitment and activation in T lymphocytes. JF - EMBO Journal AU - Braiman, Alex AU - Barda-Saad, Mira AU - Sommers, Connie L AU - Samelson, Lawrence E Y1 - 2006/02/22/ PY - 2006 DA - 2006 Feb 22 SP - 774 EP - 84 CY - Heidelberg PB - Blackwell Publishing Ltd. VL - 25 IS - 4 SN - 02614189 KW - Biology--Cytology And Histology KW - Adaptor Proteins, Signal Transducing KW - LAT protein, human KW - Membrane Proteins KW - Phosphoproteins KW - Proto-Oncogene Proteins c-vav KW - Receptors, Antigen, T-Cell KW - VAV1 protein, human KW - Phospholipase C gamma KW - CBL protein, human KW - Proto-Oncogene Proteins c-cbl KW - Microscopy, Fluorescence KW - Proto-Oncogene Proteins c-vav -- immunology KW - Adaptor Proteins, Signal Transducing -- immunology KW - Phosphorylation KW - Phosphoproteins -- immunology KW - Protein Processing, Post-Translational -- immunology KW - Membrane Proteins -- immunology KW - Humans KW - Proto-Oncogene Proteins c-cbl -- immunology KW - Jurkat Cells KW - src Homology Domains -- immunology KW - Enzyme Activation -- immunology KW - T-Lymphocytes -- enzymology KW - Lymphocyte Activation -- immunology KW - Phospholipase C gamma -- immunology KW - Signal Transduction -- immunology KW - Receptors, Antigen, T-Cell -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/195267872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Recruitment+and+activation+of+PLC%5Bgamma%5D1+in+T+cells%3A+a+new+insight+into+old+domains&rft.au=Braiman%2C+Alex%3BBarda-Saad%2C+Mira%3BSommers%2C+Connie+L%3BSamelson%2C+Lawrence+E&rft.aulast=Braiman&rft.aufirst=Alex&rft.date=2006-02-22&rft.volume=25&rft.issue=4&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Fsj.emboj.7600978 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Feb 22, 2006 N1 - Last updated - 2014-07-19 N1 - CODEN - EMJODG DO - http://dx.doi.org/10.1038/sj.emboj.7600978 ER - TY - JOUR T1 - The development of species-specific immunodiagnostics for Stachybotrys chartarum: The role of cross-reactivity AN - 17106010; 6722700 AB - Mold contamination and exposure to fungi in indoor environments has been associated with various adverse health effects but little is known about the significance of individual fungal species in the initiation or exacerbation of such effects. Using Stachybotrys chartarum as a model fungus we sought to demonstrate that monoclonal antibodies (mAbs) can provide species-specific diagnostic reagents and also be used to investigate immunological cross-reactivity patterns among fungi. Mice were immunized with S. chartarum spore walls and monoclonal antibodies were screened against 60 fungal species and 24 different isolates of S. chartarum using an indirect ELISA. One species-specific mAb (IgG sub(1)) reacted only with spore preparations but not mycelium of S. chartarum or propagules of any other fungus. Five cross-reactive mAbs (IgM) documented extensive cross-reactivity among nine related Stachybotrys species and several non-related genera including several species of Cladosporium, Memnoniella, Myrothecium and Trichoderma. We also found that the ELISA reactivity for cross-reactive antigens and different isolates of S. chartarum differed considerably for normalized total amounts of mycelial antigen. We demonstrate that mAbs and immunoassays have the potential to detect S. chartarum species-specifically. The observed reactivity patterns with cross-reactive mAbs suggest that several fungi may share common antigens and that the majority of antigens are expressed by spores and mycelia. The observed cross-reactivity patterns need to be considered for accurate interpretations of environmental and serological analyses. JF - Journal of Immunological Methods AU - Schmechel, D AU - Simpson, J P AU - Beezhold, D AU - Lewis, D M AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 1095 Willowdale Road, M/S L-4020, Morgantown, WV 26505, USA, dschmechel@cdc.gov Y1 - 2006/02/20/ PY - 2006 DA - 2006 Feb 20 SP - 150 EP - 159 PB - Elsevier B.V. VL - 309 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Cross-reactivity KW - Contamination KW - Molds KW - Cladosporium KW - Myrothecium KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Fungi KW - Memnoniella KW - Immunoglobulin G KW - Immunoglobulin M KW - Propagules KW - Stachybotrys chartarum KW - Mycelia KW - Trichoderma KW - Spores KW - Immunoassays KW - K 03086:Immunology & vaccination KW - W3 33240:Immunology KW - F 06704:Immunoassays KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=The+development+of+species-specific+immunodiagnostics+for+Stachybotrys+chartarum%3A+The+role+of+cross-reactivity&rft.au=Schmechel%2C+D%3BSimpson%2C+J+P%3BBeezhold%2C+D%3BLewis%2C+D+M&rft.aulast=Schmechel&rft.aufirst=D&rft.date=2006-02-20&rft.volume=309&rft.issue=1-2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2005.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stachybotrys chartarum; Cladosporium; Trichoderma; Myrothecium; Memnoniella; Monoclonal antibodies; Cross-reactivity; Spores; Fungi; Enzyme-linked immunosorbent assay; Mycelia; Molds; Immunoglobulin M; Contamination; Propagules; Immunoassays; Immunoglobulin G DO - http://dx.doi.org/10.1016/j.jim.2005.12.001 ER - TY - JOUR T1 - A new peptide input to learning and addiction. AN - 67657603; 16476658 AB - In this issue of Neuron, Borgland et al. report that the arousal-associated peptide orexin enhances LTP-like changes in glutamatergic excitability of ventral tegmental dopamine neurons. This parallels a similar effect of corticotropin-releasing factor and suggests a form of neuroadaptation that increases the likelihood of addiction relapse. JF - Neuron AU - Wise, Roy A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2006/02/16/ PY - 2006 DA - 2006 Feb 16 SP - 483 EP - 484 VL - 49 IS - 4 SN - 0896-6273, 0896-6273 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Neuropeptides KW - Orexins KW - Index Medicus KW - Rats KW - Animals KW - Ventral Tegmental Area -- drug effects KW - Ventral Tegmental Area -- physiology KW - Neuropeptides -- physiology KW - Learning -- physiology KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=A+new+peptide+input+to+learning+and+addiction.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2006-02-16&rft.volume=49&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Neuron. 2006 Feb 16;49(4):589-601 [16476667] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. AN - 70717682; 16262601 AB - Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a profound inflammatory syndrome with erosive arthritis, autoimmunity and myeloid hyperplasia. Previous studies showed that TTP is phosphorylated extensively in intact cells. However, limited information is available about the identities of these phosphorylation sites. We investigated the phosphorylation sites in human TTP from transfected HEK-293 cells by MS and site-directed mutagenesis. A number of phosphorylation sites including Ser66, Ser88, Thr92, Ser169, Ser186, Ser197, Ser218, Ser228, Ser276 and Ser296 were identified by MS analyses using MALDI (matrix-assisted laser-desorption-ionization)-MS, MALDI-tandem MS, LC (liquid chromatography)-tandem MS and multidimensional protein identification technology. Mutations of Ser197, Ser218 and Ser228 to alanine in the human protein significantly increased TTP's gel mobility (likely to be stoichiometric), whereas mutations at the other sites had little effect on its gel mobility. Dephosphorylation and in vivo labelling studies showed that mutant proteins containing multiple mutations were still phosphorylated, and all were able to bind to RNA probes containing AREs. Confocal microscopy showed a similar cytosolic localization of TTP among the various proteins. Ser197, Ser218 and Ser228 are predicted by motif scanning to be potential sites for protein kinase A, glycogen synthase kinase-3 and extracellular-signal-regulated kinase 1 (both Ser218 and Ser228) respectively. The present study has identified multiple phosphorylation sites in the anti-inflammatory protein TTP in mammalian cells and should provide the molecular basis for further studies on the function and regulation of TTP in controlling pro-inflammatory cytokines. JF - The Biochemical journal AU - Cao, Heping AU - Deterding, Leesa J AU - Venable, John D AU - Kennington, Elizabeth A AU - Yates, John R AU - Tomer, Kenneth B AU - Blackshear, Perry J AD - Laboratories of Neurobiology and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. caoh@ba.ars.usda.gov Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 285 EP - 297 VL - 394 KW - Anti-Inflammatory Agents KW - 0 KW - Tristetraprolin KW - Index Medicus KW - Mass Spectrometry KW - Sequence Alignment KW - Phosphorylation KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Mutation KW - Cell Line KW - Protein Transport KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Anti-Inflammatory Agents -- metabolism KW - Anti-Inflammatory Agents -- chemistry KW - Tristetraprolin -- chemistry KW - Tristetraprolin -- metabolism KW - Tristetraprolin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70717682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Identification+of+the+anti-inflammatory+protein+tristetraprolin+as+a+hyperphosphorylated+protein+by+mass+spectrometry+and+site-directed+mutagenesis.&rft.au=Cao%2C+Heping%3BDeterding%2C+Leesa+J%3BVenable%2C+John+D%3BKennington%2C+Elizabeth+A%3BYates%2C+John+R%3BTomer%2C+Kenneth+B%3BBlackshear%2C+Perry+J&rft.aulast=Cao&rft.aufirst=Heping&rft.date=2006-02-15&rft.volume=394&rft.issue=&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-24 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 2001 Oct 1;359(Pt 1):1-16 [11563964] Mol Cell Biol. 2001 Oct;21(19):6461-9 [11533235] J Biol Chem. 2002 Mar 15;277(11):9606-13 [11782475] J Biol Chem. 2002 May 17;277(20):18029-36 [11886850] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5 [12060738] Biochem Soc Trans. 2002 Nov;30(Pt 6):945-52 [12440952] Arch Biochem Biophys. 2003 Apr 1;412(1):106-20 [12646273] Mol Cell Biol. 2003 Jun;23(11):3798-812 [12748283] Nucleic Acids Res. 2003 Jul 1;31(13):3635-41 [12824383] J Biol Chem. 2003 Oct 3;278(40):38593-600 [14514795] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2011-6 [14769925] J Biol Chem. 2004 Mar 12;279(11):10176-84 [14688255] EMBO J. 2004 Mar 24;23(6):1313-24 [15014438] J Biol Chem. 2004 May 14;279(20):21489-99 [15010466] Anal Chem. 2004 May 15;76(10):2928-37 [15144207] Proteomics. 2004 Jun;4(6):1633-49 [15174133] Mol Cell Biol. 2004 Jul;24(14):6445-55 [15226444] J Biol Chem. 2004 Aug 13;279(33):34496-504 [15194681] Development. 2004 Oct;131(19):4883-93 [15342461] Biochemistry. 2004 Nov 2;43(43):13724-38 [15504035] J Biol Chem. 1975 Oct 10;250(19):7795-801 [170270] J Biol Chem. 1979 Apr 10;254(7):2499-508 [218941] Oncogene. 1989 Jan;4(1):119-20 [2915901] J Biol Chem. 1990 Sep 25;265(27):16556-63 [2204625] J Biol Chem. 1990 Nov 5;265(31):19185-91 [1699942] J Biol Chem. 1995 Jun 2;270(22):13341-7 [7768935] Immunity. 1996 May;4(5):445-54 [8630730] Mol Endocrinol. 1996 Feb;10(2):140-6 [8825554] J Biol Chem. 1997 Jan 10;272(2):952-60 [8995387] Science. 1998 Aug 14;281(5379):1001-5 [9703499] Mol Cell Biol. 1999 Jun;19(6):4311-23 [10330172] Biol Reprod. 2005 Aug;73(2):297-307 [15814898] Blood. 2000 Mar 15;95(6):1891-9 [10706852] J Biol Chem. 2000 Apr 7;275(14):10463-71 [10744736] J Am Soc Mass Spectrom. 2000 Apr;11(4):273-82 [10757163] Arch Biochem Biophys. 2000 Oct 15;382(2):310-3 [11068883] Nat Biotechnol. 2001 Apr;19(4):348-53 [11283593] Endocr Rev. 2001 Apr;22(2):153-83 [11294822] J Biol Chem. 2001 Jun 22;276(25):23144-54 [11279239] Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508 [11435226] Mol Cell Biol. 2001 Sep;21(17):5778-89 [11486017] J Biol Chem. 2001 Nov 9;276(45):42580-7 [11546803] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Membrane TNF on Immune T Cells Contributes to Immunity Against Francisella tularensis by Regulation of Autophagy T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 40014000; 4153140 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Cowley, S C AU - Goldberg, M AU - Elkins, K L Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Membranes KW - Tumor necrosis factor KW - Lymphocytes T KW - Immunity KW - Francisella tularensis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40014000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Membrane+TNF+on+Immune+T+Cells+Contributes+to+Immunity+Against+Francisella+tularensis+by+Regulation+of+Autophagy&rft.au=Cowley%2C+S+C%3BGoldberg%2C+M%3BElkins%2C+K+L&rft.aulast=Cowley&rft.aufirst=S&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Splenic, Liver, and Lung T Cells from Francisella-Immune Mice Control Bacterial Intracellular Growth via Interferon Gamma- Independent Mechanisms T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39956466; 4153113 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Elkins, K L AU - Meierovics, A I AU - Colombini, S M Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Lung KW - Mice KW - Liver KW - Interferon KW - Lymphocytes T KW - Spleen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Splenic%2C+Liver%2C+and+Lung+T+Cells+from+Francisella-Immune+Mice+Control+Bacterial+Intracellular+Growth+via+Interferon+Gamma-+Independent+Mechanisms&rft.au=Elkins%2C+K+L%3BMeierovics%2C+A+I%3BColombini%2C+S+M&rft.aulast=Elkins&rft.aufirst=K&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Production of Interferon Gamma in Response to Francisella tularensis LVS Infection T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39933808; 4153146 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - De Pascalis, R. AU - Elkins, K L Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Infection KW - ^g-Interferon KW - Francisella tularensis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Early+Production+of+Interferon+Gamma+in+Response+to+Francisella+tularensis+LVS+Infection&rft.au=De+Pascalis%2C+R.%3BElkins%2C+K+L&rft.aulast=De+Pascalis&rft.aufirst=R.&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Miniature PCR Thermocycler for Rapid Detection of Multiple Microbial Pathogens T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39933234; 4153013 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Sergeev, N V AU - Matviyenko, A AU - Herold, K AU - Rasooly, A Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Pathogens KW - Polymerase chain reaction KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Development+of+a+Miniature+PCR+Thermocycler+for+Rapid+Detection+of+Multiple+Microbial+Pathogens&rft.au=Sergeev%2C+N+V%3BMatviyenko%2C+A%3BHerold%2C+K%3BRasooly%2C+A&rft.aulast=Sergeev&rft.aufirst=N&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Detection of Abrin, Botulinum Toxin, Ricin, and Staphylococcus Enterotoxin B (SEB) in Beverages Using Luminex Multiplex Technology T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39921187; 4153025 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Garber, E A AU - Venkateswaran, K V AU - Aldrich, J L AU - OBrien, T W AU - Oliver, K G Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Toxins KW - Ricin KW - Enterotoxin B KW - Botulinum toxin KW - Beverages KW - Staphylococcus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Simultaneous+Detection+of+Abrin%2C+Botulinum+Toxin%2C+Ricin%2C+and+Staphylococcus+Enterotoxin+B+%28SEB%29+in+Beverages+Using+Luminex+Multiplex+Technology&rft.au=Garber%2C+E+A%3BVenkateswaran%2C+K+V%3BAldrich%2C+J+L%3BOBrien%2C+T+W%3BOliver%2C+K+G&rft.aulast=Garber&rft.aufirst=E&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting Conditioning Processes to Reduce Tobacco Smoking T2 - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 39913016; 4142650 JF - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Le Foll, Bernard Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Smoking KW - Tobacco smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Targeting+Conditioning+Processes+to+Reduce+Tobacco+Smoking&rft.au=Le+Foll%2C+Bernard&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - https://www.srnt.org/meeting/2006/pdf/2006Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification of 12Cys beta on tubulin as the binding site of tubulyzine AN - 19969957; 6653299 AB - We have undertaken quantitative binding site studies in order to identify the binding site of the known microtubule destabilizing agents, the tubulyzines, in the tubulin dimer. Two different approaches were employed that utilized the tubulyzines and their derivatives. The first approach was based on a chemical affinity labeling method using tubulyzine affinity derivatives, and the second approach employed the mass spectrometric measurement of the differential reactivity of cysteines using the tubulyzines and monobromobimane. Based on overlapping data from these two approaches, we propose that the tubulyzines bind at the guanosine-5'-triphosphate binding site of beta -tubulin. Interestingly, we also show that the tubulyzines' binding to tubulin induces a conformational change in tubulin that prevents further interaction of the 239Cys beta with other reagents. JF - Bioorganic and Medicinal Chemistry AU - Kim, Yeoun Jin AU - Sackett, Dan L AU - Schapira, Matthieu AU - Walsh, Daniel P AU - Min, Jaeki AU - Pannell, Lewis K AU - Chang, Young-Tae AD - National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA, yt.chang@nyu.edu Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 1169 EP - 1175 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 4 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Tublin KW - Tubulyzine KW - Binding site KW - MS-DRC KW - Microtubules KW - Data processing KW - Cysteine KW - Tubulin KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19969957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Identification+of+12Cys+beta+on+tubulin+as+the+binding+site+of+tubulyzine&rft.au=Kim%2C+Yeoun+Jin%3BSackett%2C+Dan+L%3BSchapira%2C+Matthieu%3BWalsh%2C+Daniel+P%3BMin%2C+Jaeki%3BPannell%2C+Lewis+K%3BChang%2C+Young-Tae&rft.aulast=Kim&rft.aufirst=Yeoun&rft.date=2006-02-15&rft.volume=14&rft.issue=4&rft.spage=1169&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2005.09.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Microtubules; Data processing; Cysteine; Tubulin DO - http://dx.doi.org/10.1016/j.bmc.2005.09.069 ER - TY - JOUR T1 - The Evolution and Evaluation of a Whole Blood Polymerase Chain Reaction Assay for the Detection of Invasive Aspergillosis in Hematology Patients in a Routine Clinical Setting AN - 17261804; 6988286 AB - Background. Invasive aspergillosis (IA) is associated with high mortality. Successful outcome with treatment is linked to early diagnosis. The utility of classic diagnostic methods, however, is limited. Methods. To aid in the diagnosis of IA, we retrospectively assessed our diagnostic service, using real-time polymerase chain reaction (PCR) and galactomannan sandwich enzyme-linked immunosorbent assay (ELISA). Results. A total of 203 patients at risk of invasive fungal infection were screened by PCR, and 116 of the patients were also tested by ELISA. The patient group comprised 176 patients with hematological malignancy and 28 control patients with evidence of invasive candidal infection. Consensus European Organisation for Research and Treatment of Cancer and Mycoses Study Group criteria were used to classify fungal infection, which, by definition, excluded the PCR result. The PCR method was sensitive (up to 92.3% sensitivity) and specific (up to 94.6% specificity) and had good agreement with the galactomannan ELISA (76.7%) and high-resolution computed tomography scan results. Conclusions. A negative PCR result can be used to rule out IA and to limit the need for empirical antifungal therapy; thus, it has a role in diagnosing IA infections, especially in combination with antigen testing. PCR-positive cases classified as "false positives" regularly reflect the limitations of classic microbiological procedures or restricted use of consensus clinical methods employed to classify infection. JF - Clinical Infectious Diseases AU - White, P L AU - Linton, C J AU - Perry, MD AU - Johnson, E M AU - Barnes, R A AD - Department of Medical Microbiology and National Public Health Service Cardiff, University Hospital of Wales, Cardiff Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 479 EP - 486 VL - 42 IS - 4 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Risk assessment KW - Mortality KW - Enzyme-linked immunosorbent assay KW - Invasiveness KW - Aspergillosis KW - Infection KW - Cancer KW - Blood KW - Malignancy KW - Computed tomography KW - Polymerase chain reaction KW - Evolution KW - K 03087:Fungi: human KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17261804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=The+Evolution+and+Evaluation+of+a+Whole+Blood+Polymerase+Chain+Reaction+Assay+for+the+Detection+of+Invasive+Aspergillosis+in+Hematology+Patients+in+a+Routine+Clinical+Setting&rft.au=White%2C+P+L%3BLinton%2C+C+J%3BPerry%2C+MD%3BJohnson%2C+E+M%3BBarnes%2C+R+A&rft.aulast=White&rft.aufirst=P&rft.date=2006-02-15&rft.volume=42&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Blood; Malignancy; Invasiveness; Enzyme-linked immunosorbent assay; Computed tomography; Polymerase chain reaction; Aspergillosis; Infection; Cancer; Evolution ER - TY - CPAPER T1 - FDA-CVM Guidance for Industry # 152 for the Microbial Food Safety Evaluation of Antimicrobial New Animal Drugs for Aquaculture Uses T2 - 2006 National Conference and Exposition on Aquaculture (Aquaculture America 2006) AN - 39918058; 4142473 JF - 2006 National Conference and Exposition on Aquaculture (Aquaculture America 2006) AU - Yan, S Steve AU - Abela-Ridder, Bernadette AU - Hayes, Joshua AU - Jones, Roger AU - Lampe, Karen AU - Singh, Ruby AU - Gilbert, Jeffrey Y1 - 2006/02/13/ PY - 2006 DA - 2006 Feb 13 KW - Drugs KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+National+Conference+and+Exposition+on+Aquaculture+%28Aquaculture+America+2006%29&rft.atitle=FDA-CVM+Guidance+for+Industry+%23+152+for+the+Microbial+Food+Safety+Evaluation+of+Antimicrobial+New+Animal+Drugs+for+Aquaculture+Uses&rft.au=Yan%2C+S+Steve%3BAbela-Ridder%2C+Bernadette%3BHayes%2C+Joshua%3BJones%2C+Roger%3BLampe%2C+Karen%3BSingh%2C+Ruby%3BGilbert%2C+Jeffrey&rft.aulast=Yan&rft.aufirst=S&rft.date=2006-02-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+National+Conference+and+Exposition+on+Aquaculture+%28Aquaculture+America+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.was.org/meetings/SessionsByDay.asp?MeetingCode=AA2006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update: FDA Attempts to Establish Control Data-Sets for AAA and Thoracic Endovascular Grafts T2 - XIX International Congress on Endovascular Interventions AN - 39849854; 4089049 JF - XIX International Congress on Endovascular Interventions AU - Abel, D Y1 - 2006/02/12/ PY - 2006 DA - 2006 Feb 12 KW - FDA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XIX+International+Congress+on+Endovascular+Interventions&rft.atitle=Update%3A+FDA+Attempts+to+Establish+Control+Data-Sets+for+AAA+and+Thoracic+Endovascular+Grafts&rft.au=Abel%2C+D&rft.aulast=Abel&rft.aufirst=D&rft.date=2006-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XIX+International+Congress+on+Endovascular+Interventions&rft.issn=&rft_id=info:doi/ L2 - https://www.endovascularcongress.org/new2002/program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quest for a Phenotypic Marker of Salmonella enterica serovar Newport Indicating Animal Host for Trace-Back Purposes T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39952269; 4149506 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Williams, T L AU - Musser, S M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Phenotypes KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=The+Quest+for+a+Phenotypic+Marker+of+Salmonella+enterica+serovar+Newport+Indicating+Animal+Host+for+Trace-Back+Purposes&rft.au=Williams%2C+T+L%3BMusser%2C+S+M&rft.aulast=Williams&rft.aufirst=T&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Practical Method for Measuring the H Matrix of Digital X-Ray and Cone Beam CT Imaging Systems T2 - 2006 SPIE Meeting on Medical Imaging AN - 39878691; 4097540 JF - 2006 SPIE Meeting on Medical Imaging AU - Kyprianou, I S AU - Gagne, R M AU - Badano, A G AU - Park, S AU - Gallas, B D AU - Thompson, L AU - Myers, K J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Imaging techniques KW - X-rays KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=A+Practical+Method+for+Measuring+the+H+Matrix+of+Digital+X-Ray+and+Cone+Beam+CT+Imaging+Systems&rft.au=Kyprianou%2C+I+S%3BGagne%2C+R+M%3BBadano%2C+A+G%3BPark%2C+S%3BGallas%2C+B+D%3BThompson%2C+L%3BMyers%2C+K+J&rft.aulast=Kyprianou&rft.aufirst=I&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-Dimensional Columnar CsI Model for X-Ray Imaging System Simulations Using MANTIS: Validating for Noise, Blur, and Light Output T2 - 2006 SPIE Meeting on Medical Imaging AN - 39871196; 4097506 JF - 2006 SPIE Meeting on Medical Imaging AU - Badano, A AU - Kyprianou, I S AU - Sempau, J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Simulation KW - Imaging techniques KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39871196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Three-Dimensional+Columnar+CsI+Model+for+X-Ray+Imaging+System+Simulations+Using+MANTIS%3A+Validating+for+Noise%2C+Blur%2C+and+Light+Output&rft.au=Badano%2C+A%3BKyprianou%2C+I+S%3BSempau%2C+J&rft.aulast=Badano&rft.aufirst=A&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temporal Response Measurements of Medical Liquid Crystal Displays T2 - 2006 SPIE Meeting on Medical Imaging AN - 39870969; 4097449 JF - 2006 SPIE Meeting on Medical Imaging AU - Liang, H AU - Badano, A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Crystals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Temporal+Response+Measurements+of+Medical+Liquid+Crystal+Displays&rft.au=Liang%2C+H%3BBadano%2C+A&rft.aulast=Liang&rft.aufirst=H&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential Improvement of Computerized Mass Detection on Mammograms Using a Bilateral Pairing Technique T2 - 2006 SPIE Meeting on Medical Imaging AN - 39834987; 4097335 DE: JF - 2006 SPIE Meeting on Medical Imaging AU - Paquerault, S AU - Petrick, N AU - Myers, K J AU - Sahiner, B AU - Chan, H Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39834987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Potential+Improvement+of+Computerized+Mass+Detection+on+Mammograms+Using+a+Bilateral+Pairing+Technique&rft.au=Paquerault%2C+S%3BPetrick%2C+N%3BMyers%2C+K+J%3BSahiner%2C+B%3BChan%2C+H&rft.aulast=Paquerault&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterstw LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alignment of Full and Partial CT Thoracic Scans Using Bony Structure T2 - 2006 SPIE Meeting on Medical Imaging AN - 39830691; 4097929 DE: JF - 2006 SPIE Meeting on Medical Imaging AU - Gavrielides, M A AU - Petrick, N AU - Myers, K J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39830691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Alignment+of+Full+and+Partial+CT+Thoracic+Scans+Using+Bony+Structure&rft.au=Gavrielides%2C+M+A%3BPetrick%2C+N%3BMyers%2C+K+J&rft.aulast=Gavrielides&rft.aufirst=M&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Performance of a Channelized-Ideal Observer Using Laguerre-Gauss Channels for Detecting a Gaussian Signal at a Known Location in Different Lumpy Backgrounds T2 - 2006 SPIE Meeting on Medical Imaging AN - 39821649; 4097740 JF - 2006 SPIE Meeting on Medical Imaging AU - Park, S AU - Clarkson, E AU - Barrett, H H AU - Kupinski, M A AU - Myers, K J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Channels KW - Gaussian signals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Performance+of+a+Channelized-Ideal+Observer+Using+Laguerre-Gauss+Channels+for+Detecting+a+Gaussian+Signal+at+a+Known+Location+in+Different+Lumpy+Backgrounds&rft.au=Park%2C+S%3BClarkson%2C+E%3BBarrett%2C+H+H%3BKupinski%2C+M+A%3BMyers%2C+K+J&rft.aulast=Park&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Efficiency for Detecting Gaussian Signals in Non-Gaussian Distributed Lumpy Backgrounds Using Different Display Characteristics and Scaling Methods T2 - 2006 SPIE Meeting on Medical Imaging AN - 39778748; 4097741 JF - 2006 SPIE Meeting on Medical Imaging AU - Park, S AU - Gallas, B D AU - Badano, A AU - Petrick, N AU - Myers, K J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Scaling KW - Gaussian signals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39778748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Human+Efficiency+for+Detecting+Gaussian+Signals+in+Non-Gaussian+Distributed+Lumpy+Backgrounds+Using+Different+Display+Characteristics+and+Scaling+Methods&rft.au=Park%2C+S%3BGallas%2C+B+D%3BBadano%2C+A%3BPetrick%2C+N%3BMyers%2C+K+J&rft.aulast=Park&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-Specific Statistical Model of Pathological Coronary Arteries for Generating Simulated Angiograms T2 - 2006 SPIE Meeting on Medical Imaging AN - 39768847; 4097856 JF - 2006 SPIE Meeting on Medical Imaging AU - Kyprianou, I S AU - Minai, M AU - Thompson, L AU - Myers, K J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Mathematical models KW - Statistical analysis KW - Coronary artery KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Gender-Specific+Statistical+Model+of+Pathological+Coronary+Arteries+for+Generating+Simulated+Angiograms&rft.au=Kyprianou%2C+I+S%3BMinai%2C+M%3BThompson%2C+L%3BMyers%2C+K+J&rft.aulast=Kyprianou&rft.aufirst=I&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Adopting orphan drugs--two dozen years of treating rare diseases. AN - 67625563; 16452556 JF - The New England journal of medicine AU - Haffner, Marlene E AD - Office of Orphan Products Development at the Food and Drug Administration, Rockville, Md, USA. Y1 - 2006/02/02/ PY - 2006 DA - 2006 Feb 02 SP - 445 EP - 447 VL - 354 IS - 5 KW - Immunoglobulins KW - 0 KW - Immunoglobulins, Intravenous KW - botulism immune globulin KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Immunoglobulins, Intravenous -- therapeutic use KW - Botulism -- drug therapy KW - Drug Industry KW - United States Food and Drug Administration KW - History, 20th Century KW - Humans KW - Drug Approval KW - Clinical Trials as Topic KW - Immunoglobulins -- therapeutic use KW - Rare Diseases -- drug therapy KW - Orphan Drug Production -- history KW - Rare Diseases -- history KW - Orphan Drug Production -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67625563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Adopting+orphan+drugs--two+dozen+years+of+treating+rare+diseases.&rft.au=Haffner%2C+Marlene+E&rft.aulast=Haffner&rft.aufirst=Marlene&rft.date=2006-02-02&rft.volume=354&rft.issue=5&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: N Engl J Med. 2006 Feb 2;354(5):462-71 [16452558] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border AN - 743574896; 201004-31-0295655 (CE); 12082350 (EN) AB - Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume large quantities of corn, primarily in the form of tortillas, they may be exposed to high levels of fumonisins. We examined whether or not maternal exposure to fumonisins increases the risk of NTDs in offspring using a population-based case-control study. We estimated fumonisin exposure from a postpartum sphinganine:sphingosine (sa:so) ratio, a biomarker for fumonisin exposure measured in maternal serum, and from maternal recall of periconceptional corn tortilla intake. After adjusting for confounders, moderate (301-400) compared with low ( or = 100) consumption of tortillas during the first trimester was associated with increased odds ratios (ORs) of having an NTD-affected pregnancy (OR = 2.4; 95% confidence interval, 1.1-5.3). No increased risks were observed at intakes higher than 400 tortillas (OR = 0.8 for 401-800, OR = 1.0 for 800). Based on the postpartum sa:so ratio, increasing levels of fumonisin exposure were associated with increasing ORs for NTD occurrences, except for the highest exposure category (sa:so 0.35). Our findings suggest that fumonisin exposure increases the risk of NTD, proportionate to dose, up to a threshold level, at which point fetal death may be more likely to occur. These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo. JF - Environmental Health Perspectives AU - Missmer, Stacey A AU - Suarez, Lucina AU - Felkner, Marilyn AU - Wang, Elaine PY - 2006 SP - 237 EP - 241 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Corn KW - Intakes KW - Borders KW - Tubes KW - Health KW - Defects KW - Categories KW - Embryos KW - Recall KW - Mycotoxins KW - Consumption KW - Pregnancy KW - Crops KW - Thresholds KW - Confidence intervals KW - Copyrights KW - Serums KW - Human KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743574896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Fumonisins+and+the+Occurrence+of+Neural+Tube+Defects+along+the+Texas-Mexico+Border&rft.au=Missmer%2C+Stacey+A%3BSuarez%2C+Lucina%3BFelkner%2C+Marilyn%3BWang%2C+Elaine&rft.aulast=Missmer&rft.aufirst=Stacey&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors AN - 743543125; 201004-31-0295647 (CE); 12082342 (EN) AB - As a growing applied science, nanotechnology has considerable global socioeconomic value, and the benefits afforded by nanoscale materials and processes are expected to have significant impacts on almost all industries and all areas of society. A diverse array of engineered nanoscale products and processes have emerged [e.g., carbon nanotubes, fullerene derivatives, and quantum dots (QDs)], with widespread applications in fields such as medicine, plastics, energy, electronics, and aerospace. With the nanotechnology economy estimated to be valued at dollar 1 trillion by 2012, the prevalence of these materials in society will be increasing, as will the likelihood of exposures. Importantly, the vastness and novelty of the nanotechnology frontier leave many areas unexplored, or underexplored, such as the potential adverse human health effects resulting from exposure to novel nanomaterials. It is within this context that the need for understanding the potentially harmful side effects of these materials becomes clear. The reviewed literature suggests several key points: Not all QDs are alike; engineered QDs cannot be considered a uniform group of substances. QD absorption, distribution, metabolism, excretion, and toxicity depend on multiple factors derived from both inherent physicochemical properties and environmental conditions; QD size, charge, concentration, outer coating bioactivity (capping material and functional groups), and oxidative, photolytic, and mechanical stability have each been implicated as determining factors in QD toxicity. Although they offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging, QDs may also pose risks to human health and the environment under certain conditions. Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology. JF - Environmental Health Perspectives AU - Hardman, Ron PY - 2006 SP - 165 EP - 172 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Nanostructure KW - Nanomaterials KW - Biocompatibility KW - Health KW - Nanocomposites KW - Nanotechnology KW - Toxicity KW - Quantum dots KW - Human KW - Exposure KW - Biomedical materials KW - Imaging KW - Metabolism KW - Charge KW - Aerospace KW - Arrays KW - Excretion KW - Derivatives KW - Functional groups KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743543125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Toxicologic+Review+of+Quantum+Dots%3A+Toxicity+Depends+on+Physicochemical+and+Environmental+Factors&rft.au=Hardman%2C+Ron&rft.aulast=Hardman&rft.aufirst=Ron&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Roles of Serum Selenium and Selenoproteins on Mercury Toxicity in Environmental and Occupational Exposure AN - 743514718; 201004-31-0295650 (CE); 12082345 (EN) AB - Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo. JF - Environmental Health Perspectives AU - Chen, Chunying AU - Yu, Hongwei AU - Zhao, Jiujiang AU - Li, Bai PY - 2006 SP - 297 EP - 301 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mercury KW - Serums KW - Biocompatibility KW - Surgical implants KW - Aids KW - Biomedical materials KW - Urine KW - Human KW - Toxicity KW - Health KW - Selenium KW - In vivo tests KW - In vivo testing KW - Binding KW - Populations KW - Glutathione KW - Occupational KW - Elevated KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743514718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Roles+of+Serum+Selenium+and+Selenoproteins+on+Mercury+Toxicity+in+Environmental+and+Occupational+Exposure&rft.au=Chen%2C+Chunying%3BYu%2C+Hongwei%3BZhao%2C+Jiujiang%3BLi%2C+Bai&rft.aulast=Chen&rft.aufirst=Chunying&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Influence of Large-Scale Airborne Particle Decline and Traffic-Related Exposure on Children's Lung Function AN - 743510420; 201004-31-0295639 (CE); 12082334 (EN) AB - Between 1991 and 2000, ambient air pollution in East Germany changed to resemble West German pollution levels: The concentration of total suspended particles (TSPs) decreased on a broad scale while traffic increased. During that time, we analyzed total lung capacity (TLC) and airway resistance (R(aw)) of East and West German children. We tested children 5-7 years of age (n = 2,574) with cooperation-independent body plethysmography in repeated cross sections. We used random-effect models to determine the mutually adjusted association between lung function and short-term and chronic particle exposure and its interaction with living near a busy road. Annual averages of TSPs declined from 77 to 44 microg/m2; averages on the day of investigation declined from 133 to 30 microg/m2. Differences in lung function between East and West German children vanished during the investigation time. The association of TSPs with R(aw) and TLC was stronger in children living 50 m away from busy roads. East German children from this group had an R(aw) 2.5% higher [95% confidence interval (CI), 0.0-5.1%] per 40-microg/m2 increase of daily TSP averages. TLC decreased by 6.2% (95% CI, 0.04-11.6%) per 40-microg/m2 increase in annual mean TSPs, and this effect was equally pronounced in East and West Germany. TSP exposure decreased on a broad scale between 1991 and 2000. Lower concentrations of TSPs were associated with better measures of lung function in 6-year-old children. For children living near busy roads, this effect was diminished. JF - Environmental Health Perspectives AU - Sugiri, Dorothea AU - Ranft, Ulrich AU - Schikowski, Tamara AU - Kraemer, Ursula PY - 2006 SP - 282 EP - 288 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Lungs KW - Mathematical models KW - Roads KW - Health KW - Traveling salesman problem KW - Air pollution KW - West Germany KW - Traffic flow KW - Traffic engineering KW - East Germany KW - Confidence intervals KW - Airways KW - Copyrights KW - Age KW - Adjustment KW - Plethysmography KW - Cross sections KW - Pollution levels KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743510420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Influence+of+Large-Scale+Airborne+Particle+Decline+and+Traffic-Related+Exposure+on+Children%27s+Lung+Function&rft.au=Sugiri%2C+Dorothea%3BRanft%2C+Ulrich%3BSchikowski%2C+Tamara%3BKraemer%2C+Ursula&rft.aulast=Sugiri&rft.aufirst=Dorothea&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Assessing the Measurement Precision of Various Arsenic Forms and Arsenic Exposure in the National Human Exposure Assessment Survey (NHEXAS) AN - 743475593; 201004-31-0295642 (CE); 12082337 (EN) AB - Archived samples collected from 1995 to 1997 in the National Human Exposure Assessment Survey (NHEXAS) in U.S. Environmental Protection Agency Region 5 (R5) and the Children's Study (CS) in Minnesota were analyzed for total arsenic, arsenate [As(V)], arsenite, dimethyl arsenic acid (DMA), monomethyl arsenic acid (MMA), arsenobetaine (AsB), and arsenocholine. Samples for the CS included drinking water, urine, hair, and dust; both studies included food (duplicate plate, composited 4-day food samples from participants). Except for AsB and As(V), the levels for As species measured in the food and drinking water samples were very low or nonexistent. The analytical methods used for measuring As species were sensitive to 1 ppb. During the analysis of food and drinking water samples, chromatographic peaks appeared that contained As, but they did not correspond to those being quantified. Thus, in some samples, the sum of the individual As species levels was less than the total As level measured because the unknown forms of As were not quantified. On the other hand, total As was detectable in almost all samples ( 90%) except for hair (47%), indicating that the analytical method was sufficiently sensitive. Population distributions of As concentrations measured in drinking water, food (duplicate plate), dust, urine, and hair were estimated. Exposures to total As in food for children in the CS were about twice as high as in the general R5 population (medians of 17.5 ppb and 7.72 ppb, respectively). In addition, AsB was the most frequently detected form of As in food eaten by the participants, while As(V) was only rarely detected. Thus, the predominant dietary exposure was from an organic form of As. The major form of As in drinking water was As(V). Spearman (rank) correlations and Pearson (log-concentration scale) correlations between the biomarkers (urine, hair) and the other measures (food, drinking water, dust) and urine versus hair were performed. In the NHEXAS CS, total As and AsB in the food eaten were significantly correlated with their levels in urine. Also, levels of As(V) in drinking water correlated with DMA and MMA in urine. Arsenic levels in dust did not show a relationship with urine or hair levels, and no relationship was observed for food, drinking water, and dust with hair. Urine samples were collected on days 3, 5, and 7 of participants' monitoring periods. Total As levels in urine were significantly associated across the three pairwise combinations--i.e., day 3 versus day 5, day 3 versus day 7, and day 5 versus day 7. Because the half-life of As in the body is approximately 3 days, this suggests that some exposure occurred continually from day to day. This trend was also observed for AsB, suggesting that food is primarily responsible for the continual exposure. DMA and MMA in urine were also significantly correlated but not in all combinations. JF - Environmental Health Perspectives AU - Pellizzari, Edo D AU - Clayton, C Andrew PY - 2006 SP - 220 EP - 227 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Foods KW - Urine KW - Drinking water KW - Hair KW - Arsenic KW - Dust KW - Polymethyl methacrylates KW - Correlation KW - Reproduction KW - Assessments KW - Children KW - Mathematical analysis KW - Health KW - Correlation analysis KW - Human KW - Dimethyl KW - Arsenates KW - Monitoring KW - Chromatography KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743475593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Assessing+the+Measurement+Precision+of+Various+Arsenic+Forms+and+Arsenic+Exposure+in+the+National+Human+Exposure+Assessment+Survey+%28NHEXAS%29&rft.au=Pellizzari%2C+Edo+D%3BClayton%2C+C+Andrew&rft.aulast=Pellizzari&rft.aufirst=Edo&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Assessing the Reliability and Credibility of Industry Science and Scientists AN - 743474769; 201004-31-0295648 (CE); 12082343 (EN) AB - The chemical industry extensively researches and tests its products to implement product stewardship commitments and to ensure compliance with governmental requirements. In this commentary we argue that a wide variety of mechanisms enable policymakers and the public to assure themselves that studies performed or funded by industry are identified as such, meet high scientific standards, and are not suppressed when their findings are adverse to industry's interests. The more a given study follows these practices and standards, the more confidence one can place in it. No federal laws, rules, or policies express a presumption that scientific work should be ignored or given lesser weight because of the source of its funding. To the contrary, Congress has consistently mandated that agencies allow interested or affected parties to provide information to them and fairly consider that information. All participants in scientific review panels should disclose sources of potential biases and conflicts of interest. The former should be considered in seeking a balanced panel rather than being used as a basis for disqualification. Conflicts of interest generally do require disqualification, except where outweighed by the need for a person's services. Within these constraints, chemical industry scientists can serve important and legitimate functions on scientific advisory panels and should not be unjustifiably prevented from contributing to their work. JF - Environmental Health Perspectives AU - Barrow, Craig S AU - Conrad, James W, Jr PY - 2006 SP - 153 EP - 155 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Standards KW - Panels KW - Chemical industries KW - Health KW - Scientists KW - Copyrights KW - Balancing KW - Funding KW - Confidence KW - Policies KW - Laws KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743474769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Assessing+the+Reliability+and+Credibility+of+Industry+Science+and+Scientists&rft.au=Barrow%2C+Craig+S%3BConrad%2C+James+W%2C+Jr&rft.aulast=Barrow&rft.aufirst=Craig&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Sheep Reared on Sewage Sludge-Treated Pasture: Flawed Conclusions/Sheep Reared on Sewage Sludge-Treated Pasture: Sharpe Responds AN - 743445152; 201004-31-0295649 (CE); 12082344 (EN) AB - Correspondence on Sheep Reared on Sewage Sludge-Treated Pasture: Flawed Conclusions and author's response. JF - Environmental Health Perspectives AU - Evans, Tim AU - Sharpe, Richard PY - 2006 SP - A87 EP - 8; author reply A88 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Sheep KW - Sewage KW - Health KW - Copyrights KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743445152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Sheep+Reared+on+Sewage+Sludge-Treated+Pasture%3A+Flawed+Conclusions%2FSheep+Reared+on+Sewage+Sludge-Treated+Pasture%3A+Sharpe+Responds&rft.au=Evans%2C+Tim%3BSharpe%2C+Richard&rft.aulast=Evans&rft.aufirst=Tim&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A87&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Randomized Controlled Trial Assessing Infectious Disease Risks from Bathing in Fresh Recreational Waters in Relation to the Concentration of Escherichia coli, Intestinal Enterococci, Clostridium perfringens, and Somatic Coliphages AN - 743420564; 201004-31-0295656 (CE); 12082351 (EN) AB - We performed epidemiologic studies at public freshwater bathing sites in Germany to provide a better scientific basis for the definition of recreational water quality standards. A total of 2,196 participants were recruited from the local population and randomized into bathers and nonbathers. Bathers were exposed for 10 min and had to immerse their head at least three times. Water samples for microbiological analysis were collected at 20-min intervals. Unbiased concentration-response effects with no-observed-adverse-effect levels (NOAELs) were demonstrated for three different definitions of gastroenteritis and four fecal indicator organisms. Relative risks for bathing in waters with levels above NOAELs compared with nonbathing ranged from 1.8 (95% CI, 1.2-2.6) to 4.6 (95% CI, 2.1-10.1), depending on the definition of gastroenteritis. The effect of swallowing water provided additional evidence for true dose-response relationships. Based on the NOAELs, the following guide values for water quality are suggested: 100 Escherichia coli, 25 intestinal enterococci, 10 somatic coliphages, or 10 Clostridium perfringens per 100 mL. Recreational water quality standards are intended to protect the health of those consumers who are not already immune or resistant to pathogens that may be associated with indicator organisms. In contrast to current World Health Organization recommendations, we concluded that standards should be based on rates of compliance with NOAELs rather than on attributable risks determined above NOAELs, because these risks depend mainly on the unpredictable susceptibility of the cohorts. Although in theory there is no threshold in real concentration-response relationships, we demonstrated that a NOAEL approach would be a more robust and practical solution to the complex problem of setting standards. JF - Environmental Health Perspectives AU - Wiedenmann, Albrecht AU - Krueger, Petra AU - Dietz, Klaus AU - Lopez-Pila, Juan M PY - 2006 SP - 228 EP - 236 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Standards KW - Risk KW - Health KW - Microorganisms KW - Recreational waters KW - Bathing KW - Indicators KW - Organisms KW - Clostridium KW - Quality standards KW - Escherichia coli KW - Water quality KW - Epidemiology KW - Infectious diseases KW - Intervals KW - Swallowing KW - Thresholds KW - Organizations KW - Copyrights KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743420564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Randomized+Controlled+Trial+Assessing+Infectious+Disease+Risks+from+Bathing+in+Fresh+Recreational+Waters+in+Relation+to+the+Concentration+of+Escherichia+coli%2C+Intestinal+Enterococci%2C+Clostridium+perfringens%2C+and+Somatic+Coliphages&rft.au=Wiedenmann%2C+Albrecht%3BKrueger%2C+Petra%3BDietz%2C+Klaus%3BLopez-Pila%2C+Juan+M&rft.aulast=Wiedenmann&rft.aufirst=Albrecht&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Organic Diets Significantly Lower Children's Dietary Exposure to Organophosphorus Pesticides AN - 743415891; 201004-31-0295653 (CE); 12082348 (EN) AB - We used a novel study design to measure dietary organophosphorus pesticide exposure in a group of 23 elementary school-age children through urinary biomonitoring. We substituted most of children's conventional diets with organic food items for 5 consecutive days and collected two spot daily urine samples, first-morning and before-bedtime voids, throughout the 15-day study period. We found that the median urinary concentrations of the specific metabolites for malathion and chlorpyrifos decreased to the nondetect levels immediately after the introduction of organic diets and remained nondetectable until the conventional diets were reintroduced. The median concentrations for other organophosphorus pesticide metabolites were also lower in the organic diet consumption days; however, the detection of those metabolites was not frequent enough to show any statistical significance. In conclusion, we were able to demonstrate that an organic diet provides a dramatic and immediate protective effect against exposures to organophosphorus pesticides that are commonly used in agricultural production. We also concluded that these children were most likely exposed to these organophosphorus pesticides exclusively through their diet. To our knowledge, this is the first study to employ a longitudinal design with a dietary intervention to assess children's exposure to pesticides. It provides new and persuasive evidence of the effectiveness of this intervention. JF - Environmental Health Perspectives AU - Lu, Chensheng AU - Toepel, Kathryn AU - Irish, Rene AU - Fenske, Richard A PY - 2006 SP - 260 EP - 263 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Diets KW - Pesticides KW - Children KW - Metabolites KW - Health KW - Urine KW - Copyrights KW - Chlorpyrifos KW - Foods KW - Samples KW - Voids KW - Statistical analysis KW - Protective KW - Agricultural chemicals KW - Exposure KW - Statistical methods KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743415891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Organic+Diets+Significantly+Lower+Children%27s+Dietary+Exposure+to+Organophosphorus+Pesticides&rft.au=Lu%2C+Chensheng%3BToepel%2C+Kathryn%3BIrish%2C+Rene%3BFenske%2C+Richard+A&rft.aulast=Lu&rft.aufirst=Chensheng&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Radio Frequency Nonionizing Radiation in a Community Exposed to Radio and Television Broadcasting AN - 743411453; 201004-31-0295654 (CE); 12082349 (EN) AB - Exposure to radio frequency (RF) nonionizing radiation from telecommunications is pervasive in modern society. Elevated disease risks have been observed in some populations exposed to radio and television transmissions, although findings are inconsistent. This study quantified RF exposures among 280 residents living near the broadcasting transmitters for Denver, Colorado. RF power densities outside and inside each residence were obtained, and a global positioning system (GPS) identified geographic coordinates and elevations. A view-shed model within a geographic information system (GIS) characterized the average distance and percentage of transmitters visible from each residence. Data were collected at the beginning and end of a 2.5-day period, and some measurements were repeated 8-29 months later. RF levels logged at 1-min intervals for 2.5 days varied considerably among some homes and were quite similar among others. The greatest differences appeared among homes within 1 km of the transmitters. Overall, there were no differences in mean residential RF levels compared over 2.5 days. However, after a 1- to 2-year follow-up, only 25% of exterior and 38% of interior RF measurements were unchanged. Increasing proximity, elevation, and line-of-sight visibility were each associated with elevated RF exposures. At average distances from 1-3 km, exterior RF measurements were 13-30 times greater among homes that had 50% of the transmitters visible compared with homes with or = 50% visibility at those distances. This study demonstrated that both spatial and temporal factors contribute to residential RF exposure and that GPS/GIS technologies can improve RF exposure assessment and reduce exposure misclassification. JF - Environmental Health Perspectives AU - Burch, James B AU - Clark, Maggie AU - Yost, Michael G AU - Fitzpatrick, Cole T E PY - 2006 SP - 248 EP - 253 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Radio frequencies KW - Global Positioning System KW - Satellite navigation systems KW - Geographic information systems KW - Transmitters KW - Visibility KW - Health KW - Mathematical models KW - Elevated KW - Exteriors KW - Radio KW - Elevation KW - Broadcasting KW - Residential KW - Exposure KW - Density KW - Assessments KW - Risk KW - Intervals KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743411453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Radio+Frequency+Nonionizing+Radiation+in+a+Community+Exposed+to+Radio+and+Television+Broadcasting&rft.au=Burch%2C+James+B%3BClark%2C+Maggie%3BYost%2C+Michael+G%3BFitzpatrick%2C+Cole+T+E&rft.aulast=Burch&rft.aufirst=James&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Pesticides and Parkinson's Disease-Is There a Link? AN - 743404723; 201004-31-0295661 (CE); 12082356 (EN) AB - Parkinson's disease (PD) is an idiopathic disease of the nervous system characterized by progressive tremor, bradykinesia, rigidity, and postural instability. It has been postulated that exogenous toxicants, including pesticides, might be involved in the etiology of PD. In this article we present a comprehensive review of the published epidemiologic and toxicologic literature and critically evaluate whether a relationship exists between pesticide exposure and PD. From the epidemiologic literature, there does appear to be a relatively consistent relationship between pesticide exposure and PD. This relationship appears strongest for exposure to herbicides and insecticides, and after long durations of exposure. Toxicologic data suggest that paraquat and rotenone may have neurotoxic actions that potentially play a role in the development of PD, with limited data for other pesticides. However, both the epidemiology and toxicology studies were limited by methodologic weaknesses. Particular issues of current and future interest include multiple exposures (both pesticides and other exogenous toxicants), developmental exposures, and gene-environment interactions. At present, the weight of evidence is sufficient to conclude that a generic association between pesticide exposure and PD exists but is insufficient for concluding that this is a causal relationship or that such a relationship exists for any particular pesticide compound or combined pesticide and other exogenous toxicant exposure. JF - Environmental Health Perspectives AU - Brown, Terry P AU - Rumsby, Paul C AU - Capleton, Alexander C AU - Rushton, Lesley AU - Levy, Leonard S PY - 2006 SP - 156 EP - 164 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pesticides KW - Epidemiology KW - Health KW - Nervous system KW - Copyrights KW - Instability KW - Stability KW - Toxicology KW - Herbicides KW - Links KW - Insecticides KW - Rigidity KW - Tremors KW - Paraquat KW - Etiology KW - Parkinson's disease KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743404723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Pesticides+and+Parkinson%27s+Disease-Is+There+a+Link%3F&rft.au=Brown%2C+Terry+P%3BRumsby%2C+Paul+C%3BCapleton%2C+Alexander+C%3BRushton%2C+Lesley%3BLevy%2C+Leonard+S&rft.aulast=Brown&rft.aufirst=Terry&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prevalence and Implementation of IAQ Programs in U.S. Schools. AN - 743394176; 201004-31-0295927 (CE); 12083020 (EN) AB - BACKGROUND: Ecologic studies are commonly used to report associations between short-term air pollution and mortality. In such studies, the unit of observation is the day rather than the individual. Moreover, individual data on the subjects are rarely available, which limits the assessment of individual risk factors. These associations can also be investigated using case-crossover studies. However, by definition, individual risk factors are not studied, and such studies analyze only dead subjects, which limits the statistical power. OBJECTIVE: We suggest that the survival analysis is more suitable when cohorts are examined with a time-dependent ecologic exposure. To our knowledge, to date this type of analysis has never been proposed. DESIGN, PARTICIPANTS, MEASUREMENTS: In the present study we used a Cox proportional hazards model to investigate the distribution over time of the short-term effect of black smoke and sulfur dioxide in 439 nonaccidental and 158 cardiorespiratory deaths among the 1,469 subjects of the Personnes Agees QUID (PAQUID) cohort in Bordeaux, France. The model has a delayed entry and a polynomial distributed lag from 0 to 5 days. Results are adjusted for individual risk factors, temperature, relative humidity, weekday, season, influenza epidemics, and a time function to control temporal trends. RESULTS: We identified a positive and significant association between cardiorespiratory mortality and black smoke, with a 24% increase in deaths 3 days after a 10-microg/m3 increase in black smoke (95% confidence interval, 4-47%). CONCLUSIONS: We conclude that the Cox proportional hazards model with time-dependent covariates is very suitable to investigate simultaneously the short-term effect of air pollution on health and the effect of individual risk factors on a cohort study. JF - Environmental Health Perspectives AU - J, Lepeule AU - V, Rondeau AU - L, Filleul AU - JF, Dartigues PY - 2006 SP - 242 EP - 247 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Mathematical models KW - Smoke KW - Air pollution KW - Ecological monitoring KW - Mortality KW - Health KW - Hazards KW - Death KW - Relative humidity KW - Assessments KW - Time functions KW - Seasons KW - Confidence intervals KW - Sulfur dioxide KW - Medicine KW - Copyrights KW - Design engineering KW - Influenza KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743394176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prevalence+and+Implementation+of+IAQ+Programs+in+U.S.+Schools.&rft.au=J%2C+Lepeule%3BV%2C+Rondeau%3BL%2C+Filleul%3BJF%2C+Dartigues&rft.aulast=J&rft.aufirst=Lepeule&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Personality Traits in Miners with Past Occupational Elemental Mercury Exposure AN - 743390703; 201004-31-0295638 (CE); 12082333 (EN) AB - In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Questionnaire and the Emotional States Questionnaire. The relationship between the indices of past occupational exposure and the observed personality traits was evaluated using Pearson's correlation coefficient and on a subgroup level by machine learning methods (regression trees). The ex-mercury miners were intermittently exposed to Hg0 for a period of 7-31 years. The means of exposure-cycle urine mercury (U-Hg) concentrations ranged from 20 to 120 microg/L. The results obtained indicate that ex-miners tend to be more introverted and sincere, more depressive, more rigid in expressing their emotions and are likely to have more negative self-concepts than controls, but no correlations were found with the indices of past occupational exposure. Despite certain limitations, results obtained by the regression tree suggest that higher alcohol consumption per se and long-term intermittent, moderate exposure to Hg0 (exposure cycle mean U-Hg concentrations 38.7 53.5 microg/L) in interaction with alcohol remain a plausible explanation for the depression associated with negative self-concept found in subgroups of ex-mercury miners. This could be one of the reason for the higher risk of suicide among miners of the Idrija Mercury Mine in the last 45 years. JF - Environmental Health Perspectives AU - Grum, Darja Kobal AU - Kobal, Alfred B AU - Arneric, Niko AU - Horvat, Milena PY - 2006 SP - 290 EP - 296 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Miners KW - Occupational KW - Personality KW - Mercury KW - Control equipment KW - Exposure KW - Regression KW - Alcohols KW - Health KW - Trees KW - Subgroups KW - Risk KW - Silicides KW - Correlation KW - Intermetallics KW - Copyrights KW - Emotions KW - Correlation coefficients KW - Urine KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743390703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Personality+Traits+in+Miners+with+Past+Occupational+Elemental+Mercury+Exposure&rft.au=Grum%2C+Darja+Kobal%3BKobal%2C+Alfred+B%3BArneric%2C+Niko%3BHorvat%2C+Milena&rft.aulast=Grum&rft.aufirst=Darja&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Methylmercury Exposure and Developmental Outcomes: Review of the Evidence and Discussion of Future Directions AN - 743389973; 201004-31-0295637 (CE); 12082332 (EN) AB - I conducted a review of the published literature to assess the strength of the evidence for an association between prenatal exposure to methylmercury (MeHg) and subsequent child development. I identified 12 studies on this subject published since 1980. Of these, 3 were longitudinal studies--2 conducted in the Seychelle Islands, and 1 in the Faroe Islands. Nine were cross-sectional studies conducted in different countries where seafood, a source of MeHg, constituted a major part of the diet. The ages of the children studied ranged from 2 weeks to 12 years. The results of the longitudinal studies were contradictory. Researchers in the Faroe Islands identified an association between MeHg exposure and developmental effects, whereas those in the Seychelle Islands identified no such association. This inconsistency was mirrored in the results of the cross-sectional studies where there were some positive and some negative findings. It was concluded that it was not possible from currently available data to determine whether there is an association between prenatal MeHg exposure and adverse developmental effects in children. In advance of future research, consideration should be given to resolving the uncertainties surrounding exposure assessment and outcome measurement, as both elements varied between studies. It was suggested that questions of exposure assessment would benefit from the application of an expert review process. Outcome assessment would benefit from the development of theoretically based measures of specific aspects of cognitive functioning to replace the relatively crude measures of attainment and IQ currently employed in most studies. This would assist in the development of classic longitudinal studies by allowing repeated assessment over the full age range and providing data that are more readily interpretable and comparable between studies. JF - Environmental Health Perspectives AU - Spurgeon, Anne PY - 2006 SP - 307 EP - 312 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Islands KW - Assessments KW - Cross sections KW - Health KW - Children KW - Age KW - Seychelles KW - Seafood KW - Copyrights KW - Diets KW - Uncertainty KW - Strength KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743389973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Methylmercury+Exposure+and+Developmental+Outcomes%3A+Review+of+the+Evidence+and+Discussion+of+Future+Directions&rft.au=Spurgeon%2C+Anne&rft.aulast=Spurgeon&rft.aufirst=Anne&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Apparent Half-Lives of Hepta- to Decabrominated Diphenyl Ethers in Human Serum as Determined in Occupationally Exposed Workers AN - 743379705; 201004-31-0295646 (CE); 12082341 (EN) AB - The aim of the present study was to model apparent serum half-lives of polybrominated diphenyl ethers (PBDEs) with 7-10 bromine substituents. Workers with occupational exposure to PBDEs have elevated serum levels of PBDEs, but these substances are also found in the general population and are ubiquitous environmental contaminants. The calculations were based on exposure assessments of rubber workers (manufactured flame-retarded rubber compound) and electronics dismantlers who donated blood during a period with no work-related exposures to PBDEs, and referents without any known occupational exposure (clerks, cleaners, and abattoir workers). The workers had previously been found to have elevated levels of high- and medium-brominated diphenyl ethers compared with the referent populations. We performed nonlinear mixed-effects modeling of kinetics, using data from previous and present chemical analyses. The calculated apparent half-life for decabromodiphenyl ether (BDE-209) was 15 days (95% confidence interval, 11-18 days). The three nona-BDEs and four octa-BDE congeners were found to have half-lives of 18-39 and 37-91 days, respectively. BDE-209 has a short half-life in human blood. Because BDE-209 is commonly present in humans in general, the results of this study imply that humans must be more or less continuously exposed to BDE-209 to sustain the serum concentrations observed. BDE-209 is more readily transformed and/or eliminated than are lower brominated diphenyl ether congeners, and human health risk must be assessed accordingly. JF - Environmental Health Perspectives AU - Thuresson, Kaj AU - Hoeglund, Peter AU - Hagmar, Lars AU - Sjoedin, Andreas PY - 2006 SP - 176 EP - 181 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Ethers KW - Human KW - Serums KW - Health KW - Occupational KW - Mathematical models KW - Elevated KW - Congeners KW - Rubber KW - Blood KW - Exposure KW - Electronics KW - Assessments KW - Risk KW - Contaminants KW - Nonlinearity KW - Cleaners KW - Bromine KW - Bromination KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743379705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Apparent+Half-Lives+of+Hepta-+to+Decabrominated+Diphenyl+Ethers+in+Human+Serum+as+Determined+in+Occupationally+Exposed+Workers&rft.au=Thuresson%2C+Kaj%3BHoeglund%2C+Peter%3BHagmar%2C+Lars%3BSjoedin%2C+Andreas&rft.aulast=Thuresson&rft.aufirst=Kaj&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - New Evidence on Variations of Human Body Burden of Methylmercury from Fish Consumption AN - 743371139; 201004-31-0295636 (CE); 12082331 (EN) AB - Epidemiologic studies commonly use mercury (Hg) level in hair as a valid proxy to estimate human exposure to methylmercury (MeHg) through fish consumption. This study presents the results yielded by a complete data set on fish consumption habits, Hg levels in edible fish resources, and corresponding Hg accumulation in hair, gathered in three distinct communities of eastern Canada. For one of these communities, the average hair Hg concentration was 14 times less than the expected value based on calculated daily oral exposure and current knowledge of MeHg metabolism. This finding could be explained by differences in specific genetic characteristics and/or interactive effects of other dietary components. JF - Environmental Health Perspectives AU - Canuel, Rene AU - de Grosbois, Sylvie Boucher AU - Atikesse, Laura AU - Lucotte, Marc PY - 2006 SP - 302 EP - 306 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mercury KW - Fish KW - Hair KW - Communities KW - Health KW - Genetics KW - Interactive KW - Mathematical analysis KW - Copyrights KW - Edible KW - Human KW - Metabolism KW - Estimates KW - Human body KW - Habits KW - Epidemiology KW - Proxy client servers KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743371139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=New+Evidence+on+Variations+of+Human+Body+Burden+of+Methylmercury+from+Fish+Consumption&rft.au=Canuel%2C+Rene%3Bde+Grosbois%2C+Sylvie+Boucher%3BAtikesse%2C+Laura%3BLucotte%2C+Marc&rft.aulast=Canuel&rft.aufirst=Rene&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - NEW THINKING on NEURODEVELOPMENT AN - 743371034; 201004-31-0295664 (CE); 12082359 (EN) AB - Rising diagnoses of neurodevelopmental disorders are leading scientists to take a harder look at environmental exposures in utero and during childhood that may be at least partly to blame for the rise. A number of agents, including metals, man-made chemicals, immunotoxicants, and infectious pathogens, have been implicated in neurodevelopmental effects; some researchers are also looking at the possible role of gene-environment interactions. Federal support for work in this sphere is increasing, and an expert working group recently formulated a set of best practices for studying neurodevelopmental outcomes. Challenges remain in educating the public and clinicians alike about the links between environmental insults and these disorders. JF - Environmental Health Perspectives AU - Szpir, Michael PY - 2006 SP - A100 EP - A107 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Disorders KW - Health KW - Pathogens KW - Copyrights KW - Education KW - Links KW - Scientists KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743371034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=NEW+THINKING+on+NEURODEVELOPMENT&rft.au=Szpir%2C+Michael&rft.aulast=Szpir&rft.aufirst=Michael&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A100&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Phthalates Not in Plastic Food Packaging AN - 743370634; 201004-31-0295665 (CE); 12082360 (EN) AB - Correspondence on Phthalates Not in Plastic Food Packaging. JF - Environmental Health Perspectives AU - Enneking, Patricia A PY - 2006 SP - A89 EP - A90 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Phthalates KW - Food packaging KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743370634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Phthalates+Not+in+Plastic+Food+Packaging&rft.au=Enneking%2C+Patricia+A&rft.aulast=Enneking&rft.aufirst=Patricia&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A89&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Environmental Health Sciences and the Community AN - 743355013; 201004-31-0295667 (CE); 12082362 (EN) AB - Environmental health science investigators train for many years to acquire the in-depth knowledge and expertise critical to successful research. The inherent components of hypothesis generation, study design, methodology, analysis, and interpretation of research which are central to the investigative process take years of dedicated work to develop. Moreover, the very aim of research--getting at the truth--requires an unbiased and impartial approach to answering the questions asked. However, scientists can't always do patient-oriented research on their own, which is why the community is such an important component of our success at the NIEHS. Community partners can identify environmental exposures that are of concern, encourage the public to participate in research, help to set research priorities, and provide the bridge to developing and implementing effective interventions to reduce exposures and prevent disease. JF - Environmental Health Perspectives AU - Schwartz, David A AU - Sassaman, Anne P AU - Collman, Gwen W PY - 2006 SP - A80 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Communities KW - Exposure KW - Trains KW - Copyrights KW - Design engineering KW - Scientists KW - Priorities KW - Methodology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743355013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Environmental+Health+Sciences+and+the+Community&rft.au=Schwartz%2C+David+A%3BSassaman%2C+Anne+P%3BCollman%2C+Gwen+W&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A80&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Mortality from Ischemic Heart Disease and Diabetes Mellitus (Type 2) in Four U.S. Wheat-Producing States: A Hypothesis-Generating Study AN - 743303841; 201004-31-0295645 (CE); 12082340 (EN) AB - In this ecologic study I examined ischemic heart disease (IHD) and diabetes mortality in rural agricultural counties of Minnesota, Montana, North Dakota, and South Dakota, in association with environmental exposure to chlorophenoxy herbicides, using wheat acreage as a surrogate exposure. I collected data on agricultural land use and 1979-1998 mortality from the U.S. Department of Agriculture and the Centers for Disease Control and Prevention websites, respectively. Counties were grouped based on percentage of land area dedicated to wheat farming. Poisson relative risks (RR) and 95% confidence intervals (CIs), comparing high- and medium- with low-wheat counties, were obtained for IHD, the subcategories acute myocardial infarction (AMI) and coronary atherosclerosis (CAS), and diabetes, adjusting for sex, age, mortality cohort, and poverty index. Mortality from IHD was modestly increased (RR = 1.08; 95% CI, 1.04-1.12). Analyses of its two major forms were more revealing. Compared with low-wheat counties, mortality in high-wheat counties from AMI increased (RR = 1.20; 95% CI, 1.14-1.26), and mortality from CAS decreased (RR = 0.89; 95% CI, 0.83-0.96). Mortality from AMI was more pronounced for those 65 years of age (RR = 1.31; 95% CI 1.22-1.39). Mortality from type 2 diabetes increased (RR = 1.16; 95% CI, 1.08-1.24). These results suggest that the underlying cause of mortality from AMI and type 2 diabetes increased and the underlying cause of mortality from CAS decreased in counties where a large proportion of the land area is dedicated to spring and durum wheat farming. Firm conclusions on causal inference cannot be reached until more definitive studies have been conducted. JF - Environmental Health Perspectives AU - Schreinemachers, Dina M PY - 2006 SP - 186 EP - 193 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mortality KW - Diabetes KW - Farming KW - Wheat KW - Heart diseases KW - Land KW - Farms KW - Health KW - Farmlands KW - Age KW - Inference KW - Websites KW - Risk KW - Disease control KW - Ecological monitoring KW - Land use KW - Confidence intervals KW - Atherosclerosis KW - Herbicides KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743303841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mortality+from+Ischemic+Heart+Disease+and+Diabetes+Mellitus+%28Type+2%29+in+Four+U.S.+Wheat-Producing+States%3A+A+Hypothesis-Generating+Study&rft.au=Schreinemachers%2C+Dina+M&rft.aulast=Schreinemachers&rft.aufirst=Dina&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Measuring Potential Dermal Transfer of a Pesticide to Children in a Child Care Center AN - 743303461; 201004-31-0295640 (CE); 12082335 (EN) AB - Currently, the major determinants of children's exposure to pesticides are not fully understood, and approaches for measuring and assessing dermal exposure in a residential setting have not been sufficiently evaluated. In one approach, dermal exposure is estimated using empirically derived transfer coefficients. To assess the feasibility of using this approach for assessing children's exposure to pesticides, we conducted a study was conducted in a child care center that had a preexisting contract with a pest control service for regular monthly pesticide applications. Children in the selected child care center were monitored using full-body cotton garments to measure dermal loading. Pesticide residues on classroom surfaces were measured in the areas where the children spent time. Measured surface-wipe loadings ranged from 0.47 to 120 ng/cm2, and total garment loadings ranged from 0.5 to 660 pg/cm2. The garment and surface loading measurements were used to calculate dermal-transfer coefficients for use in assessing children's residential exposure to pesticides. Dermal-transfer coefficients calculated using these data range from approximately 10 to 6,000 cm2/hr. The wide range in these values demonstrates the importance of developing standard surface-measurement protocols if this approach is to be used to assess dermal exposure in a residential environment. The upper-range values resulting from this study were found to be similar to the default value used by the U.S. Environmental Protection Agency to assess children's dermal exposures resulting from contact with indoor surfaces. JF - Environmental Health Perspectives AU - Hubal, Elaine A Cohen AU - Egeghy, Peter P AU - Leovic, Kelly W AU - Akland, Gerry G PY - 2006 SP - 264 EP - 269 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Pesticides KW - Garments KW - Residential KW - Mathematical analysis KW - Health KW - Pests KW - Indoor KW - Contact KW - Determinants KW - Standards KW - Classrooms KW - Copyrights KW - Empirical analysis KW - Feasibility KW - Residues KW - Contracts KW - Cotton KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743303461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Measuring+Potential+Dermal+Transfer+of+a+Pesticide+to+Children+in+a+Child+Care+Center&rft.au=Hubal%2C+Elaine+A+Cohen%3BEgeghy%2C+Peter+P%3BLeovic%2C+Kelly+W%3BAkland%2C+Gerry+G&rft.aulast=Hubal&rft.aufirst=Elaine+A&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Molecular Medicine: An Introductory Text, 3rd Edition AN - 743288553; 201004-31-0295635 (CE); 12082330 (EN) AB - The third edition of Molecular Medicine: An Introductory Text, like the previous editions, continues to provide a contemporary and succinct overview of DNA in medicine. Chapter topics include a history of molecular medicine, DNA, RNA, genes, and chromosomes; Mendelian genetic traits; complex genetic traits; genomics, proteomics, and bioinformatics; genetic and cellular therapies; reproduction and development; infectious diseases; forensic medicine and science; and ethical, legal, and social issues. The new chapters added to this edition represent the developments in genomics, proteomics, and bioinformatics. JF - Environmental Health Perspectives AU - Kang, Y James PY - 2006 SP - a126 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Medicine KW - Genetics KW - Texts KW - Health KW - Bioinformatics KW - Deoxyribonucleic acid KW - Proteomics KW - Reproduction KW - Cellular KW - Forensic engineering KW - Ribonucleic acids KW - Ethics KW - Infectious diseases KW - Therapy KW - Chromosomes KW - Legal KW - Genes KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743288553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Molecular+Medicine%3A+An+Introductory+Text%2C+3rd+Edition&rft.au=Kang%2C+Y+James&rft.aulast=Kang&rft.aufirst=Y&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=a126&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Elemental Mercury Spills AN - 743263308; 201004-31-0295662 (CE); 12082357 (EN) AB - Sources of elemental mercury (Hg0) include old natural gas regulators, manometers, sphygmomanometers, thermometers, and thermostats. Causes of Hg0 spills include improper storage, container breakage, children playing with Hg0, the breakage of devices containing Hg0, and ritualistic use of Hg0. Inhalation is the primary exposure route for Hg0. Mercury released into the environment can enter lakes and streams, where bacteria convert it into methylmercury, which bioaccumulates in fish. Chronic exposure to Hg0 vapors can damage the kidneys and neurologic system. Short-term exposure to high levels of Hg0 vapors may cause lung damage, nausea, vomiting, diarrhea, increases in blood pressure or heart rate, skin rashes, and eye irritation, among other effects. Minimizing Hg0 dispersal is important after an Hg0 spill. Tracking by shoes or apparel or vacuuming can spread Hg0, increasing airborne concentrations and cleanup costs. The Illinois Department of Public Health's response to an Hg0 spill depends on the size of the spill. Airborne concentrations after large spills are mapped with a mercury vapor analyzer (MVA). The cleanup begins with the spill site and any hot spots that were identified with the MVA. Hard surfaces can usually be cleaned, but contaminated porous items must be discarded. Leaving marginally contaminated items outdoors for a month or more during warm weather may dissipate the Hg0. After a cleanup, clearance sampling is conducted to determine if further cleanup is needed. The best way to prevent Hg0 spills is reduce its use. Key words: cleanup, elemental mercury, health effects, mercury, prevention, remediation, spill, spill management. JF - Environmental Health Perspectives AU - Baughman, Thomas A PY - 2006 SP - 147 EP - 152 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Spills KW - Cleaning KW - Mercury KW - Bacteria KW - Health KW - Breakage KW - Contamination KW - Damage KW - Vomiting KW - Dissipation KW - Remediation KW - Thermometers KW - Spreads KW - Weather KW - Climatology KW - Public health KW - Irritation KW - Manometers KW - Streams KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743263308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Elemental+Mercury+Spills&rft.au=Baughman%2C+Thomas+A&rft.aulast=Baughman&rft.aufirst=Thomas&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Flu Vaccine Production Gets a Shot in the Arm AN - 743196129; 201004-31-0295663 (CE); 12082358 (EN) AB - Although the H5N1 avian flu currently affects only a relatively small number of people, scientists are worried that if it mutates--as flu strains often do--it could cause a global pandemic. In the event of a pandemic, rapid creation of a vaccine will be critical. Researchers have now perfected an advanced method of producing the "seed" virus used to produce influenza vaccines, a technique known as reverse genetics. This method is much quicker than the conventional vaccine production process, an advantage that could potentially save millions of lives. JF - Environmental Health Perspectives AU - Hood, Ernie PY - 2006 SP - A108 EP - A111 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Vaccines KW - Health KW - Genetics KW - Influenza KW - Hoods KW - Copyrights KW - Shot KW - Strain KW - Rapids KW - Scientists KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743196129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Flu+Vaccine+Production+Gets+a+Shot+in+the+Arm&rft.au=Hood%2C+Ernie&rft.aulast=Hood&rft.aufirst=Ernie&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A108&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effects of Multiday Exposure to Ozone on Airway Inflammation as Determined Using Sputum Induction AN - 743193782; 201004-31-0295643 (CE); 12082338 (EN) AB - Single short-term exposures to ozone are known to cause acute changes in pulmonary function and neutrophilic airway inflammation. The respiratory health effects of repeated exposures are not as well studied. Pulmonary function decrements are known to attenuate, but it is less clear how injury and inflammation are affected. Using sputum induction (SI) to sample respiratory tract lining fluid after single- and multiday exposures, we designed a study to test the hypothesis that neutrophils would increase after multiday exposure compared with single-day exposure. In a randomized, crossover design, 15 normal healthy subjects were exposed to O3 (0.2 ppm) under two conditions: for 4 hr for 1 day (1D) and for 4 hr for 4 consecutive days (4D). Pulmonary function testing was performed immediately before and after each 4-hr exposure. The SI was performed 18 hr after the end of the 1D and 4D conditions. The symptom and pulmonary function data followed a pattern seen in other multiday O3 exposure studies, with the greatest changes occurring on the second day. In contrast to previous studies using bronchoalveolar lavage, however, there was a significant increase in the percentage of neutrophils and a significant decrease in the percentage of macrophages after the 4D condition compared with the 1D condition. Given that SI likely samples proximal airways better than distal lung, these results add to the body of evidence that differential airway compartmental responses to O3 occur in humans and other species. JF - Environmental Health Perspectives AU - Ratto, Jeffrey AU - Wong, Hofer AU - Liu, Jane AU - Fahy, John PY - 2006 SP - 209 EP - 212 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pulmonary functions KW - Health KW - Airways KW - Ozone KW - Crossovers KW - Fluid flow KW - Fluid dynamics KW - Macrophages KW - Injuries KW - Commercial planes KW - Copyrights KW - Fluids KW - Commercial aircraft KW - Bronchoalveolar lavage KW - Lungs KW - Human KW - Exposure KW - Attenuation KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743193782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effects+of+Multiday+Exposure+to+Ozone+on+Airway+Inflammation+as+Determined+Using+Sputum+Induction&rft.au=Ratto%2C+Jeffrey%3BWong%2C+Hofer%3BLiu%2C+Jane%3BFahy%2C+John&rft.aulast=Ratto&rft.aufirst=Jeffrey&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effects of Developmental Exposure to 2,2',4,4',5-Pentabromodiphenyl Ether (PBDE-99) on Sex Steroids, Sexual Development, and Sexually Dimorphic Behavior in Rats AN - 743192964; 201004-31-0295644 (CE); 12082339 (EN) AB - Increasing concentrations of polybrominated flame retardants, including polybrominated diphenyl ethers (PBDEs), in breast milk cause concern about possible developmental effects in nursed babies. Because previous studies in rats have indicated effects on sex steroids and sexually dimorphic behavior after maternal exposure to polychlorinated biphenyls (PCBs), our goal in the present study was to determine if developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) induces similar endocrine-mediated effects. Pregnant rats were exposed to vehicle or PBDE-99 (1 or 10 mg/kg body weight, daily during gestational days 10-18). For comparison, we also included a group exposed to the technical PCB mixture Aroclor 1254 (30 mg/kg body weight, daily). PBDE exposure resulted in pronounced decreases in circulating sex steroids in male offspring at weaning and in adulthood. Female offspring were less affected. Anogenital distance was reduced in male offspring. Puberty onset was delayed in female offspring at the higher dose level, whereas a slight acceleration was detected in low-dose males. The number of primordial/primary ovarian follicles was reduced in females at the lower dose, whereas decline of secondary follicles was more pronounced at the higher dose. Sweet preference was dose-dependently increased in PBDE-exposed adult males, indicating a feminization of this sexually dimorphic behavior. Aroclor 1254 did not alter sweet preference and numbers of primordial/primary and secondary follicles but it did affect steroid concentrations in males and sexual development in both sexes. PBDE concentrations in tissues of dams and offspring were highest on gestational day 19. These results support the hypothesis that PBDEs are endocrine-active compounds and interfere with sexual development and sexually dimorphic behavior. JF - Environmental Health Perspectives AU - Lilienthal, Hellmuth AU - Hack, Alfons AU - Roth-Haerer, Astrid AU - Grande, Simone Wichert AU - Talsness, Chris E PY - 2006 SP - 194 EP - 201 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Males KW - Sex KW - Steroids KW - Ethers KW - Females KW - Rats KW - Sweets KW - Health KW - Exposure KW - Body weight KW - Milk KW - Acceleration KW - Circulating KW - Breast KW - Circuit boards KW - Flame retardants KW - Adults KW - Dams KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743192964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effects+of+Developmental+Exposure+to+2%2C2%27%2C4%2C4%27%2C5-Pentabromodiphenyl+Ether+%28PBDE-99%29+on+Sex+Steroids%2C+Sexual+Development%2C+and+Sexually+Dimorphic+Behavior+in+Rats&rft.au=Lilienthal%2C+Hellmuth%3BHack%2C+Alfons%3BRoth-Haerer%2C+Astrid%3BGrande%2C+Simone+Wichert%3BTalsness%2C+Chris+E&rft.aulast=Lilienthal&rft.aufirst=Hellmuth&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - February 2006 NIEHS News. AN - 743187970; 201004-31-0295926 (CE); 12083019 (EN) AB - Short articles on: Making Progress on Breast Cancer; Headliners: Decreased Melatonin Production Linked to Light Exposure. JF - Environmental Health Perspectives AU - L, Claudio AU - T, Tillett PY - 2006 SP - A98 EP - A99 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Copyrights KW - Medicine KW - Libraries KW - Health KW - Breast KW - Cancer KW - Melatonin KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743187970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=February+2006+NIEHS+News.&rft.au=L%2C+Claudio%3BT%2C+Tillett&rft.aulast=L&rft.aufirst=Claudio&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A98&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - February 2006 forum. AN - 743187934; 201004-31-0295925 (CE); 12083018 (EN) AB - Short articles on: Marine Toxin Hinders Cognitive Development; Cloud Banks: Airlines Save Halon; PD Gene and Oxidative Stress; Expanding the Medicine Chest; EHPnet: National Institute of Neurological Disorders and Stroke; The Beat. JF - Environmental Health Perspectives AU - C, Potera AU - A, Burton AU - ML, Phillips AU - M, Szpir AU - EE, Dooley PY - 2006 SP - A95 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Medicine KW - Copyrights KW - Genes KW - Disorders KW - Halons KW - Toxins KW - Commercial planes KW - Banks KW - Health KW - Clouds KW - Marine KW - Libraries KW - Strokes KW - Commercial aircraft KW - Chest KW - Stresses KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743187934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=February+2006+forum.&rft.au=C%2C+Potera%3BA%2C+Burton%3BML%2C+Phillips%3BM%2C+Szpir%3BEE%2C+Dooley&rft.aulast=C&rft.aufirst=Potera&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A95&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers AN - 743176037; 201004-31-0295659 (CE); 12082354 (EN) AB - Jet propulsion fuel 8 (JP-8) is the major jet fuel used worldwide and has been recognized as a major source of chemical exposure, both inhalation and dermal, for fuel-cell maintenance workers. We investigated the contributions of dermal and inhalation exposure to JP-8 to the total body dose of U.S. Air Force fuel-cell maintenance workers using naphthalene as a surrogate for JP-8 exposure. Dermal, breathing zone, and exhaled breath measurements of naphthalene were obtained using tape-strip sampling, passive monitoring, and glass bulbs, respectively. Levels of urinary 1- and 2-naphthols were determined in urine samples and used as biomarkers of JP-8 exposure. Multiple linear regression analyses were conducted to investigate the relative contributions of dermal and inhalation exposure to JP-8, and demographic and work-related covariates, to the levels of urinary naphthols. Our results show that both inhalation exposure and smoking significantly contributed to urinary 1-naphthol levels. The contribution of dermal exposure was significantly associated with levels of urinary 2-naphthol but not with urinary 1-naphthol among fuel-cell maintenance workers who wore supplied-air respirators. We conclude that dermal exposure to JP-8 significantly contributes to the systemic dose and affects the levels of urinary naphthalene metabolites. Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure. JF - Environmental Health Perspectives AU - Chao, Yi-Chun E AU - Kupper, Lawrence L AU - Serdar, Berrin AU - Egeghy, Peter P PY - 2006 SP - 182 EP - 185 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Naphthalene KW - Maintenance KW - Fuel cells KW - Inhalation KW - Naphthol KW - Health KW - Jet fuels KW - Metabolism KW - Sampling KW - Respirators KW - Chaos theory KW - Glass KW - Metabolites KW - Regression analysis KW - Military planes KW - Monitoring KW - Gain KW - Demographics KW - Copyrights KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743176037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Dermal+Exposure+to+Jet+Fuel+JP-8+Significantly+Contributes+to+the+Production+of+Urinary+Naphthols+in+Fuel-Cell+Maintenance+Workers&rft.au=Chao%2C+Yi-Chun+E%3BKupper%2C+Lawrence+L%3BSerdar%2C+Berrin%3BEgeghy%2C+Peter+P&rft.aulast=Chao&rft.aufirst=Yi-Chun&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Case-Crossover Study of Wintertime Ambient Air Pollution and Infant Bronchiolitis AN - 743152733; 201004-31-0295651 (CE); 12082346 (EN) AB - We examined the association of infant bronchiolitis with acute exposure to ambient air pollutants. DESIGN: We employed a time-stratified case-crossover method and based the exposure windows on a priori, biologically based hypotheses. PARTICIPANTS: We evaluated effects in 19,901 infants in the South Coast Air Basin of California in 1995-2000 with a hospital discharge record for bronchiolitis in the first year of life (International Classification of Diseases, 9th Revision, CM466.1). EVALUATIONS/MEASUREMENTS: Study subjects' ZIP code was linked to ambient air pollution monitors to derive exposures. We estimated the risk of bronchiolitis hospitalization associated with increases in wintertime ambient air pollutants using conditional logistic regression. RESULTS: We observed no increased risk after acute exposure to particulate matter or = 2.5 microm in aerodynamic diameter (PM2.5), carbon monoxide, or nitrogen dioxide. PM2.5 exposure models suggested a 26-41% increased risk in the most premature infants born at gestational ages between 25 and 29 weeks; however, these findings were based on very small numbers. CONCLUSIONS: We found little support for a link between acute increases in ambient air pollution and infant bronchiolitis except modestly increased risk for PM2.5 exposure among infants born very prematurely. In these infants, the periods of viral acquisition and incubation concurred with the time of increased risk. RELEVANCE TO PROFESSIONAL PRACTICE: We present novel data for the infant period and the key respiratory disease of infancy, bronchiolitis. Incompletely explained trends in rising bronchiolitis hospitalization rates and increasing number of infants born prematurely underscore the importance of evaluating the impact of ambient air pollution in this age group in other populations and studies. JF - Environmental Health Perspectives AU - Karr, Catherine AU - Lumley, Thomas AU - Shepherd, Kristen AU - Davis, Robert PY - 2006 SP - 277 EP - 281 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Infants KW - Risk KW - Air pollution KW - Health KW - Pollutants KW - Age KW - Diseases KW - Nitrogen dioxide KW - Monitors KW - Regression KW - Populations KW - Links KW - Discharge KW - Hospitals KW - Mathematical models KW - Respiratory diseases KW - Classification KW - Basins KW - Coastal environments KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743152733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Case-Crossover+Study+of+Wintertime+Ambient+Air+Pollution+and+Infant+Bronchiolitis&rft.au=Karr%2C+Catherine%3BLumley%2C+Thomas%3BShepherd%2C+Kristen%3BDavis%2C+Robert&rft.aulast=Karr&rft.aufirst=Catherine&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Correspondence on Phosphine Toxicity: Ethical Questions and authors' response. AN - 743149792; 201004-31-0295923 (CE); 12083016 (EN) AB - Correspondence on Phosphine Toxicity: Ethical Questions and authors' response. JF - Environmental Health Perspectives AU - EL, Anderson AU - PA, McDaniel AU - G, Solomon AU - RE, Malone PY - 2006 SP - A84; author reply A84 EP - 5 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Toxicity KW - Phosphines KW - Ethics KW - Copyrights KW - Medicine KW - Libraries KW - Health KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743149792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Correspondence+on+Phosphine+Toxicity%3A+Ethical+Questions+and+authors%27+response.&rft.au=EL%2C+Anderson%3BPA%2C+McDaniel%3BG%2C+Solomon%3BRE%2C+Malone&rft.aulast=EL&rft.aufirst=Anderson&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A84%3B+author+reply+A84&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Correspondence on Effects of Lead on IQ in Children and Authors' Response and authors' response. AN - 743149159; 201004-31-0295924 (CE); 12083017 (EN) AB - Correspondence on Effects of Lead on IQ in Children and Authors' Response and authors' response. JF - Environmental Health Perspectives AU - CB, Ernhart AU - BP, Lanphear AU - R, Hornung AU - J, Khoury AU - K, Yolton AU - KN, Dietrich PY - 2006 SP - A85 EP - A87 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Copyrights KW - Medicine KW - Libraries KW - Back propagation KW - Health KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743149159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Correspondence+on+Effects+of+Lead+on+IQ+in+Children+and+Authors%27+Response+and+authors%27+response.&rft.au=CB%2C+Ernhart%3BBP%2C+Lanphear%3BR%2C+Hornung%3BJ%2C+Khoury%3BK%2C+Yolton%3BKN%2C+Dietrich&rft.aulast=CB&rft.aufirst=Ernhart&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A85&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Cancer in Persons Working in Dry Cleaning in the Nordic Countries AN - 743135621; 201004-31-0295657 (CE); 12082352 (EN) AB - U.S. studies have reported an increased risk of esophageal and some other cancers in dry cleaners exposed to tetrachloroethylene. We investigated whether the U.S. findings could be reproduced in the Nordic countries using a series of case-control studies nested in cohorts of laundry and dry-cleaning workers identified from the 1970 censuses in Denmark, Norway, Sweden, and Finland. Dry-cleaning work in the Nordic countries during the period when tetrachloroethylene was the dominant solvent was not associated with an increased risk of esophageal cancer [rate ratio (RR) = 0.76; 95% confidence interval (CI), 0.34-1.69], but our study was hampered by some unclassifiable cases. The risks of cancer of the gastric cardia, liver, pancreas, and kidney and non-Hodgkin lymphoma were not significantly increased.Assistants in dry-cleaning shops had a borderline significant excess risk of cervical cancer not found in women directly involved in dry cleaning. We found an excess risk of bladder cancer (RR = 1.44; 95% CI, 1.07-1.93) not associated with length of employment. The finding of no excess risk of esophageal cancer in Nordic dry cleaners differs from U.S. findings. Chance, differences in level of exposure to tetrachloroethylene, and confounding may explain the findings. The overall evidence on bladder cancer in dry cleaners is equivocal. JF - Environmental Health Perspectives AU - Lynge, Elsebeth AU - Andersen, Aage AU - Rylander, Lars AU - Tinnerberg, Haakan PY - 2006 SP - 213 EP - 219 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cancer KW - Risk KW - Dry cleaning KW - Tetrachloroethylene KW - Nordic countries KW - Health KW - Bladder KW - Confidence intervals KW - Copyrights KW - Solvents KW - Kidneys KW - Liver KW - Employment KW - Pancreas KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743135621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cancer+in+Persons+Working+in+Dry+Cleaning+in+the+Nordic+Countries&rft.au=Lynge%2C+Elsebeth%3BAndersen%2C+Aage%3BRylander%2C+Lars%3BTinnerberg%2C+Haakan&rft.aulast=Lynge&rft.aufirst=Elsebeth&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Breast Milk Dioxins in Hong Kong and Pearl River Delta AN - 743102550; 201004-31-0295658 (CE); 12082353 (EN) AB - There are no previous reports from South China on chemically determined polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) in human breast milk expressed as World Health Organization (WHO) toxic equivalents (TEQs). In a 2002-2003 WHO exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 PCDD/F and dioxin-like PCB congeners. Total WHO-TEQs ranged from 8.97 to 16.7 pg/g fat (weighted mean, 12.9 pg; weighted median, 13.4 pg). Variations in TEQs included positive associations with age (R2 = 0.73, p 0.0005), higher consumption of dairy products and seafood, and lower TEQs in overseas mothers and ever-smokers. Congener profiles indicated geographic specificity of exposure in Hong Kong, mainland China, and overseas Asian countries, including higher proportions of PCB-TEQs (overseas) and PCDF-TEQs (mainland China). The median TEQs of PCDD/Fs (8.69 pg/g fat) and PCBs (4.73 pg/g fat) in Hong Kong were highest among the five Asian Pacific countries but lower than the levels for at least half of the European countries that participated in the WHO study. However, future international studies should incorporate mother's age in the design of the pooling strategy to allow standardization by other exposure factors and valid comparisons among different countries. The findings allow support for the WHO breast-feeding advisory. Trends in human dioxin levels in the region cannot yet be determined, and rigorous controls are needed to reduce emissions of dioxins and human exposure in mainland China. JF - Environmental Health Perspectives AU - Hedley, Anthony J AU - Wong, Tze Wai AU - Hui, Lai Ling AU - Malisch, Rainer AU - Nelson, Edmund A S PY - 2006 SP - 202 EP - 208 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Milk KW - Overseas KW - Breast KW - Health KW - Human KW - Dioxins KW - Congeners KW - Age KW - Asian KW - Seafood KW - Circuit boards KW - Austenitic stainless steels KW - Standardization KW - Toxic KW - Mass spectrometry KW - Strategy KW - Organizations KW - Rivers KW - Pools KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743102550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Breast+Milk+Dioxins+in+Hong+Kong+and+Pearl+River+Delta&rft.au=Hedley%2C+Anthony+J%3BWong%2C+Tze+Wai%3BHui%2C+Lai+Ling%3BMalisch%2C+Rainer%3BNelson%2C+Edmund+A+S&rft.aulast=Hedley&rft.aufirst=Anthony&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Blood Mercury Reporting in NHANES: Identifying Asian, Pacific Islander, Native American, and Multiracial Groups AN - 743090452; 201004-31-0295660 (CE); 12082355 (EN) AB - INTRODUCTION: Asians, Pacific Islanders, and Native Americans are a potentially high-risk group for dietary exposure to methylmercury through fish consumption. However, blood mercury levels in this group have not been identified in recent reports of the National Health and Nutrition Examination Survey (NHANES) for the years 1999-2002. METHODS: We used NHANES data from 1999-2002 to obtain population estimates of blood mercury levels among women of childbearing age classified as belonging to the "other" racial/ethnic group (Asian, Pacific Islander, Native American, and multiracial; n = 140). Blood mercury levels in this group were compared with those among all other women participants, classified as Mexican American, non-Hispanic black, non-Hispanic white, and "other" Hispanic. RESULTS: An estimated 16.59 +/- 4.0% (mean +/- SE) of adult female participants who self-identified as Asian, Pacific Islander, Native American, or multiracial (n = 140) had blood mercury levels or = 5.8 microg/L, and 27.26 +/- 4.22% had levels or = 3.5 microg/L. Among remaining survey participants (n = 3,497), 5.08 +/- 0.90% had blood mercury levels or = 5.8 microg/L, and 10.86 +/- 1.45% had levels or = 3.5 microg/L. CONCLUSIONS: Study subjects in NHANES who self-identified as Asian, Pacific Islander, Native American, or multiracial had a higher prevalence of elevated blood mercury than all other racial/ethnic participants in the survey. Future studies should address reasons for the high mercury levels in this group and explore possible interventions for lowering risk of methylmercury exposure in this population. JF - Environmental Health Perspectives AU - Hightower, Jane M AU - O'Hare, Ann AU - Hernandez, German T PY - 2006 SP - 173 EP - 175 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mercury KW - Blood KW - Asian KW - Health KW - Ethnic KW - Fish KW - Copyrights KW - Elevated KW - Females KW - Estimates KW - Nutrition KW - Adults KW - Risk KW - Age KW - Reporting KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743090452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Blood+Mercury+Reporting+in+NHANES%3A+Identifying+Asian%2C+Pacific+Islander%2C+Native+American%2C+and+Multiracial+Groups&rft.au=Hightower%2C+Jane+M%3BO%27Hare%2C+Ann%3BHernandez%2C+German+T&rft.aulast=Hightower&rft.aufirst=Jane&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Human Breast Milk Contamination with Phthalates and Alterations of Endogenous Reproductive Hormones in Infants Three Months of Age AN - 743082981; 201004-31-0295652 (CE); 12082347 (EN) AB - Phthalates adversely affect the male reproductive system in animals. We investigated whether phthalate monoester contamination of human breast milk had any influence on the postnatal surge of reproductive hormones in newborn boys as a sign of testicular dysgenesis. DESIGN: We obtained biologic samples from a prospective Danish-Finnish cohort study on cryptorchidism from 1997 to 2001. We analyzed individual breast milk samples collected as additive aliquots 1-3 months postnatally (n = 130; 62 cryptorchid/68 healthy boys) for phthalate monoesters [mono-methyl phthalate (mMP), mono-ethyl phthalate (mEP), mono-n-butyl phthalate (mBP), mono-benzyl phthalate (mBzP), mono-2-ethylhexyl phthalate (mEHP), mono-isononyl phthalate (miNP)]. We analyzed serum samples (obtained in 74% of all boys) for gonadotropins, sex-hormone binding globulin (SHBG), testosterone, and inhibin B. RESULTS: All phthalate monoesters were found in breast milk with large variations [medians (minimum-maximum)]: mMP 0.10 ( 0.01-5.53 microg/L), mEP 0.95 (0.07-41.4 microg/L), mBP 9.6 (0.6-10,900 microg/L), mBzP 1.2 (0.2-26 microg/L), mEHP 11 (1.5-1,410 microg/L), miNP 95 (27-469 microg/L). Finnish breast milk had higher concentrations of mBP, mBzP, mEHP, and Danish breast milk had higher values for miNP (p = 0.0001-0.056). No association was found between phthalate monoester levels and cryptorchidism. However, mEP and mBP showed positive correlations with SHBG (r = 0.323, p = 0.002 and r = 0.272, p = 0.01, respectively); mMP, mEP, and mBP with LH:free testosterone ratio (r = 0.21-0.323, p = 0.002-0.044) and miNP with luteinizing hormone (r = 0.243, p = 0.019). mBP was negatively correlated with free testosterone (r = -0.22, p = 0.033). Other phthalate monoesters showed similar but nonsignificant tendencies. CONCLUSIONS: Our data on reproductive hormone profiles and phthalate exposures in newborn boys are in accordance with rodent data and suggest that human Leydig cell development and function may also be vulnerable to perinatal exposure to some phthalates. Our findings are also in line with other recent human data showing incomplete virilization in infant boys exposed to phthalates prenatally. JF - Environmental Health Perspectives AU - Main, Katharina M AU - Mortensen, Gerda K AU - Kaleva, Marko M AU - Boisen, Kirsten A PY - 2006 SP - 270 EP - 276 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Phthalates KW - Milk KW - Breast KW - Hormones KW - Human KW - Testosterone KW - Exposure KW - Infants KW - Correlation KW - Health KW - Contamination KW - Surges KW - Binding KW - Reproductive systems KW - Additives KW - Males KW - Copyrights KW - Design engineering KW - Globulins KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743082981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Human+Breast+Milk+Contamination+with+Phthalates+and+Alterations+of+Endogenous+Reproductive+Hormones+in+Infants+Three+Months+of+Age&rft.au=Main%2C+Katharina+M%3BMortensen%2C+Gerda+K%3BKaleva%2C+Marko+M%3BBoisen%2C+Kirsten+A&rft.aulast=Main&rft.aufirst=Katharina&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Proteomic Evaluation of Neonatal Exposure to 2,2',4,4',5-Pentabromodiphenyl Ether AN - 743073927; 201004-31-0295641 (CE); 12082336 (EN) AB - Exposure to the brominated flame retardant 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) during the brain growth spurt disrupts normal brain development in mice and results in disturbed spontaneous behavior in adulthood. The neurodevelopmental toxicity of PBDE-99 has been reported to affect the cholinergic and catecholaminergic systems. In this study we use a proteomics approach to study the early effect of PBDE-99 in two distinct regions of the neonatal mouse brain, the striatum and the hippocampus. A single oral dose of PBDE-99 (12 mg/kg body weight) or vehicle was administered to male NMRI mice on neonatal day 10, and the striatum and the hippocampus were isolated. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we found 40 and 56 protein spots with significantly (p 0.01) altered levels in the striatum and the hippocampus, respectively. We used matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-ToF-MS) to determine the protein identity of 11 spots from the striatum and 10 from the hippocampus. We found that the levels of proteins involved in neurodegeneration and neuroplasticity (e.g., Gap-43/neuromodulin, stathmin) were typically altered in the striatum, and proteins involved in metabolism and energy production [e.g., alpha-enolase; gamma-enolase; ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit (Atp5b); and alpha-synuclein] were typically altered in the hippocampus. Interestingly, many of the identified proteins have been linked to protein kinase C signaling. In conclusion, we identify responses to early exposure to PBDE-99 that could contribute to persistent neurotoxic effects. This study also shows the usefulness of proteomics to identify potential biomarkers of developmental neurotoxicity of organohalogen compounds. JF - Environmental Health Perspectives AU - Alm, Henrik AU - Scholz, Birger AU - Fischer, Celia AU - Kultima, Kim PY - 2006 SP - 254 EP - 259 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Proteins KW - Hippocampus KW - Brain KW - Proteomics KW - Mice KW - Ethers KW - Spots KW - Kinases KW - Health KW - Ionization KW - Electrophoresis KW - Toxicity KW - Beta KW - Flame retardants KW - Cholinergics KW - Fluorescence KW - Lasers KW - Spontaneous KW - Bromination KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743073927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Proteomic+Evaluation+of+Neonatal+Exposure+to+2%2C2%27%2C4%2C4%27%2C5-Pentabromodiphenyl+Ether&rft.au=Alm%2C+Henrik%3BScholz%2C+Birger%3BFischer%2C+Celia%3BKultima%2C+Kim&rft.aulast=Alm&rft.aufirst=Henrik&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Phthalate Exposure and Anogenital Distance in Male Infants AN - 743072329; 201004-31-0295666 (CE); 12082361 (EN) AB - Correspondence on Prenatal Phthalate Exposure and Anogenital Distance in Male Infants. JF - Environmental Health Perspectives AU - Swan, Shanna H PY - 2006 SP - A88 EP - A89 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Males KW - Health KW - Infants KW - Phthalates KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743072329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Phthalate+Exposure+and+Anogenital+Distance+in+Male+Infants&rft.au=Swan%2C+Shanna+H&rft.aulast=Swan&rft.aufirst=Shanna&rft.date=2006-02-01&rft.volume=114&rft.issue=2&rft.spage=A88&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. AN - 70734616; 16428448 AB - Genetic and biochemical analyses have uncovered an essential role for nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating phase II xenobiotic metabolism and antioxidant response. Here we show that Nrf2 protects against the ovarian toxicity of 4-vinylcyclohexene diepoxide (VCD) in mice. Nrf2-/- female mice exposed to VCD exhibit an age-dependent decline in reproduction leading to secondary infertility accompanied by hypergonadotropic hypogonadism after 30 weeks of age. VCD is shown to selectively destroy small ovarian follicles, resulting in early depletion of functional follicles. Treatment with VCD induces apoptotic death in cultured cells and in ovarian follicles, suggesting apoptosis as a mechanism of follicle loss. Loss of Nrf2 function blocks the basal and inducible expression of microsomal epoxide hydrolase, a key enzyme in the detoxification of VCD, and increases the oxidative stress in cells that is further exacerbated by VCD. Foxo3a, a repressor in the early stages of follicle activation, displays reduced expression in Nrf2-/- ovaries, causing accelerated growth of follicles in the absence of exposure to exogenous chemicals. Furthermore, Foxo3a is degraded through the 26S proteasome pathway in untreated cells and is induced by VCD via both Nrf2-dependent transcription and protein stabilization. This study demonstrates that Nrf2 serves as an essential sensor and regulator of chemical homeostasis in ovarian cells, protecting the cells from toxic chemicals by controlling metabolic detoxification, reactive oxygen species defense, and Foxo3a expression. In addition, these findings raise the possibility that exposure to environmental or occupational ovotoxicants plays a role in the premature ovarian failure commonly associated with infertility and premature aging in women. JF - Molecular and cellular biology AU - Hu, Xiaoming AU - Roberts, Jenny R AU - Apopa, Patrick L AU - Kan, Yuet Wai AU - Ma, Qiang AD - Receptor Biology Laboratory, TMBB/HELD/NIOSH/CDC, Mailstop 3014, 1095 Willowdale Rd., Morgantown, WV 26505, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 940 EP - 954 VL - 26 IS - 3 SN - 0270-7306, 0270-7306 KW - Cyclohexanes KW - 0 KW - Cyclohexenes KW - Forkhead Box Protein O3 KW - Forkhead Transcription Factors KW - FoxO3 protein, mouse KW - NF-E2-Related Factor 2 KW - Nfe2l2 protein, mouse KW - Vinyl Compounds KW - 4-vinyl-1-cyclohexene dioxide KW - 596C064IG4 KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Animals KW - Epoxide Hydrolases -- metabolism KW - Apoptosis KW - Mice KW - Oxidative Stress -- genetics KW - Mice, Mutant Strains KW - Proteasome Endopeptidase Complex -- metabolism KW - Inactivation, Metabolic -- genetics KW - Mutation KW - Signal Transduction KW - Female KW - Vinyl Compounds -- toxicity KW - Primary Ovarian Insufficiency -- metabolism KW - Forkhead Transcription Factors -- genetics KW - Ovarian Follicle -- metabolism KW - Ovarian Follicle -- pathology KW - NF-E2-Related Factor 2 -- genetics KW - Cyclohexanes -- toxicity KW - Primary Ovarian Insufficiency -- genetics KW - Forkhead Transcription Factors -- metabolism KW - Primary Ovarian Insufficiency -- chemically induced KW - Ovarian Follicle -- drug effects KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70734616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Accelerated+ovarian+failure+induced+by+4-vinyl+cyclohexene+diepoxide+in+Nrf2+null+mice.&rft.au=Hu%2C+Xiaoming%3BRoberts%2C+Jenny+R%3BApopa%2C+Patrick+L%3BKan%2C+Yuet+Wai%3BMa%2C+Qiang&rft.aulast=Hu&rft.aufirst=Xiaoming&rft.date=2006-02-01&rft.volume=26&rft.issue=3&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 1997 Dec;147(2):351-62 [9439730] Toxicol Appl Pharmacol. 1999 Sep 15;159(3):185-93 [10486305] J Toxicol Environ Health A. 2003 Jun 13;66(11):995-1013 [12775513] Science. 2003 Jul 11;301(5630):215-8 [12855809] Mol Cell Biol. 2003 Dec;23(23):8786-94 [14612418] J Biol Chem. 2003 Nov 28;278(48):48021-9 [12968018] Biochem J. 2004 Jan 1;377(Pt 1):205-13 [14510636] Methods Mol Biol. 2004;263:141-60 [14976365] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2975-80 [14978268] Science. 2004 Mar 26;303(5666):2011-5 [14976264] Free Radic Biol Med. 2004 Aug 15;37(4):433-41 [15256215] Physiol Rev. 1980 Jan;60(1):51-89 [6243782] Annu Rev Pharmacol Toxicol. 1980;20:513-31 [6992704] Toxicol Appl Pharmacol. 1980 Apr;53(2):249-59 [6771884] Am J Hum Genet. 1984 Nov;36(6):1341-8 [6517055] Toxicol Appl Pharmacol. 1990 Sep 15;105(3):364-71 [2237911] Free Radic Biol Med. 2000 Apr 15;28(8):1266-78 [10889457] Toxicol Pathol. 2001 Jan-Feb;29(1):91-9 [11215690] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] Biol Reprod. 2001 Jul;65(1):87-93 [11420227] Kidney Int. 2001 Oct;60(4):1343-53 [11576348] Science. 2002 Mar 29;295(5564):2450-2 [11884717] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] Nature. 2002 Sep 19;419(6904):316-21 [12239572] Toxicol Appl Pharmacol. 2002 Oct 15;184(2):107-15 [12408955] J Environ Pathol Toxicol Oncol. 2002;21(4):343-50 [12510963] Chem Res Toxicol. 2003 Mar;16(3):249-60 [12641424] Toxicol Appl Pharmacol. 1990 Sep 15;105(3):372-81 [2237912] Int Rev Cytol. 1991;124:43-101 [2001918] J Cell Biol. 1992 Nov;119(3):493-501 [1400587] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9926-30 [7937919] IARC Monogr Eval Carcinog Risks Hum. 1994;60:347-59 [7869574] Annu Rev Pharmacol Toxicol. 1996;36:307-31 [8725392] Scand J Work Environ Health. 1996 Oct;22(5):387-91 [8923614] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8 [8943040] Toxicol Appl Pharmacol. 1997 May;144(1):36-44 [9169067] Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22 [9240432] Rev Reprod. 1998 Sep;3(3):183-95 [9829553] Genes Dev. 1999 Jan 1;13(1):76-86 [9887101] Annu Rev Pharmacol Toxicol. 1999;39:103-25 [10331078] Toxicol Appl Pharmacol. 1999 Aug 1;158(3):244-52 [10438657] Fertil Steril. 1998 Jul;70(1):1-15 [9660412] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. AN - 70728339; 16405514 AB - Activated microglia are implicated in the pathogenesis of disease-, trauma- and toxicant-induced damage to the CNS, and strategies to modulate microglial activation are gaining impetus. A novel action of the tetracycline derivative minocycline is the ability to inhibit inflammation and free radical formation, factors that influence microglial activation. Minocycline is therefore being tested as a neuroprotective agent to alleviate CNS damage, although findings so far have yielded mixed results. Here, we showed that administration of a single low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or methamphetamine (METH), a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in substantia nigra, increased the expression of mRNAs encoding microglia-associated factors F4/80, interleukin (IL)-1alpha, IL-6, monocyte chemoattractant protein-1 (MCP-1, CCL2) and tumor necrosis factor (TNF)-alpha. Minocycline treatment attenuated MPTP- or METH-mediated microglial activation, but failed to afford neuroprotection. Lack of neuroprotection was shown to be due to the inability of minocycline to abolish the induction of TNF-alpha and its receptors, thereby failing to modulate TNF signaling. Thus, TNF-alpha appeared to be an obligatory component of dopaminergic neurotoxicity. To address this possibility, we examined the effects of MPTP or METH in mice lacking genes encoding IL-6, CCL2 or TNF receptor (TNFR)1/2. Deficiency of either IL-6 or CCL2 did not alter MPTP neurotoxicity. However, deficiency of both TNFRs protected against the dopaminergic neurotoxicity of MPTP. Taken together, our findings suggest that attenuation of microglial activation is insufficient to modulate neurotoxicity as transient activation of microglia may suffice to initiate neurodegeneration. These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease. JF - Journal of neurochemistry AU - Sriram, Krishnan AU - Miller, Diane B AU - O'Callaghan, James P AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 706 EP - 718 VL - 96 IS - 3 SN - 0022-3042, 0022-3042 KW - Ccl2 protein, mouse KW - 0 KW - Chemokine CCL2 KW - Dopamine Agents KW - Glial Fibrillary Acidic Protein KW - Interleukin-6 KW - Receptors, Tumor Necrosis Factor KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Methamphetamine KW - 44RAL3456C KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Minocycline KW - FYY3R43WGO KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Chemokine CCL2 -- genetics KW - Dopamine Agents -- toxicity KW - Tyrosine 3-Monooxygenase -- metabolism KW - Drug Interactions KW - Neurons -- metabolism KW - Dose-Response Relationship, Drug KW - Neurons -- drug effects KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Blotting, Western -- methods KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Homovanillic Acid -- metabolism KW - Methamphetamine -- toxicity KW - Mice, Mutant Strains KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Cell Count -- methods KW - Interleukin-6 -- genetics KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacology KW - Chromatography, High Pressure Liquid -- methods KW - Time Factors KW - Male KW - Corpus Striatum -- cytology KW - Minocycline -- pharmacology KW - Receptors, Tumor Necrosis Factor -- physiology KW - Dopamine -- metabolism KW - Microglia -- drug effects KW - Receptors, Tumor Necrosis Factor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70728339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Minocycline+attenuates+microglial+activation+but+fails+to+mitigate+striatal+dopaminergic+neurotoxicity%3A+role+of+tumor+necrosis+factor-alpha.&rft.au=Sriram%2C+Krishnan%3BMiller%2C+Diane+B%3BO%27Callaghan%2C+James+P&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2006-02-01&rft.volume=96&rft.issue=3&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2006-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients. AN - 70723207; 16449681 AB - Treatments for Hodgkin lymphoma are associated with large relative risks of acute myeloid leukemia (AML), but there are few estimates of the excess absolute risk (EAR), a useful measure of disease burden. One-year Hodgkin lymphoma survivors (N = 35,511) were identified within 14 population-based cancer registries in Nordic countries and North America from January 1, 1970, through December 31, 2001. We used Poisson regression analysis to model the EAR of AML, per 10,000 person-years. A total of 217 Hodgkin lymphoma survivors were diagnosed with AML (10.8 expected; unadjusted EAR = 6.2; 95% confidence interval = 5.4 to 7.1). Excess absolute risk for AML was highest during the first 10 years after Hodgkin lymphoma diagnosis but remained elevated thereafter. In subsequent analyses, adjusted for time since Hodgkin lymphoma diagnosis and presented for the 5-9 year interval, the EAR was statistically significantly (P or = 35 age groups, respectively), which may be associated with modifications in chemotherapy. JF - Journal of the National Cancer Institute AU - Schonfeld, Sara J AU - Gilbert, Ethel S AU - Dores, Graça M AU - Lynch, Charles F AU - Hodgson, David C AU - Hall, Per AU - Storm, Hans AU - Andersen, Aage AU - Pukkala, Eero AU - Holowaty, Eric AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fosså, Sophie D AU - Allan, James M AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 215 EP - 218 VL - 98 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - SEER Program KW - Poisson Distribution KW - Research Design KW - Risk Assessment KW - Antineoplastic Agents -- adverse effects KW - Registries KW - North America -- epidemiology KW - Adult KW - Confounding Factors (Epidemiology) KW - Incidence KW - Ontario -- epidemiology KW - Middle Aged KW - Scandinavian and Nordic Countries -- epidemiology KW - Finland -- epidemiology KW - Female KW - Male KW - Neoplasms, Second Primary -- epidemiology KW - Leukemia, Myeloid, Acute -- epidemiology KW - Leukemia, Myeloid, Acute -- chemically induced KW - Hodgkin Disease -- drug therapy KW - Hodgkin Disease -- therapy KW - Neoplasms, Second Primary -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Acute+myeloid+leukemia+following+Hodgkin+lymphoma%3A+a+population-based+study+of+35%2C511+patients.&rft.au=Schonfeld%2C+Sara+J%3BGilbert%2C+Ethel+S%3BDores%2C+Gra%C3%A7a+M%3BLynch%2C+Charles+F%3BHodgson%2C+David+C%3BHall%2C+Per%3BStorm%2C+Hans%3BAndersen%2C+Aage%3BPukkala%2C+Eero%3BHolowaty%2C+Eric%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFoss%C3%A5%2C+Sophie+D%3BAllan%2C+James+M%3BTravis%2C+Lois+B&rft.aulast=Schonfeld&rft.aufirst=Sara&rft.date=2006-02-01&rft.volume=98&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity. AN - 70682367; 16226009 AB - Methoxychlor (MC) was developed as a replacement for the banned pesticide DDT. After in vivo administration, it is metabolized in the liver to 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which is proposed to be the active agent. Both MC and HPTE have been shown to exhibit weak estrogenic and antiandrogenic activities, and they are thought to exert their effects through estrogen and androgen receptors, respectively. Although in vitro studies using cultured rat Leydig cells have reported that HPTE inhibits both basal and hCG-stimulated testosterone formation, the response of circulating testosterone levels to in vivo MC has been more variable. Therefore, the current studies evaluated whether the daily in vivo administration of MC (0, 5, 40 and 200 mg/kg body weight) for a short duration (days 54-60 of age) by gavage altered serum testosterone levels and ex vivo Leydig cell testosterone formation in young adult male rats. These results demonstrate that both fluid-retained and fluid-expressed seminal vesicle weights declined to 44 and 60% of control, respectively, in the 200 mg/kg MC-exposed animals. Similarly, serum testosterone and dehydroepiandrosterone levels declined to 41 and 45% of control, respectively, in the 200 mg/kg MC-exposed animals; however, serum LH and FSH levels were unaffected. Ex vivo Leydig cell basal testosterone formation over 4h declined to 49% of control in animals exposed to 200 mg/kg MC, and ex vivo Leydig cell P450 cholesterol side-chain cleavage activity declined to 79 and 50% of control in animals exposed to 40 and 200 mg/kg of MC, respectively, supporting previous in vitro studies which demonstrated the sensitivity of this step to MC. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Murono, Eisuke P AU - Derk, Raymond C AU - Akgul, Yucel AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. eem8@cdc.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 148 EP - 153 VL - 21 IS - 2 SN - 0890-6238, 0890-6238 KW - Chorionic Gonadotropin KW - 0 KW - Follicle Stimulating Hormone, Human KW - Indicators and Reagents KW - Insecticides KW - Testosterone KW - 3XMK78S47O KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Luteinizing Hormone KW - 9002-67-9 KW - Cholesterol KW - 97C5T2UQ7J KW - Cholesterol Side-Chain Cleavage Enzyme KW - EC 1.14.15.6 KW - Methoxychlor KW - RIA79UD69L KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Chorionic Gonadotropin -- pharmacology KW - Corticosterone -- blood KW - Body Weight -- drug effects KW - Luteinizing Hormone -- blood KW - Cell Separation KW - Male KW - Follicle Stimulating Hormone, Human -- blood KW - Organ Size -- drug effects KW - Depression, Chemical KW - Dehydroepiandrosterone -- metabolism KW - Insecticides -- toxicity KW - Leydig Cells -- metabolism KW - Leydig Cells -- enzymology KW - Cholesterol Side-Chain Cleavage Enzyme -- antagonists & inhibitors KW - Testosterone -- metabolism KW - Cholesterol -- metabolism KW - Testosterone -- blood KW - Cholesterol Side-Chain Cleavage Enzyme -- metabolism KW - Leydig Cells -- drug effects KW - Methoxychlor -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70682367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=In+vivo+exposure+of+young+adult+male+rats+to+methoxychlor+reduces+serum+testosterone+levels+and+ex+vivo+Leydig+cell+testosterone+formation+and+cholesterol+side-chain+cleavage+activity.&rft.au=Murono%2C+Eisuke+P%3BDerk%2C+Raymond+C%3BAkgul%2C+Yucel&rft.aulast=Murono&rft.aufirst=Eisuke&rft.date=2006-02-01&rft.volume=21&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 67804562; 16566620 AB - To present nationally representative data on the lifetime prevalence and comorbidity of 8 specific drug use disorders, separately for abuse and dependence, and mood and anxiety disorders. Data come from a representative sample (N=43,093) of the United States civilian, noninstitutional population 18 years and older. Diagnoses of mood, anxiety, and drug use disorders were based upon face-to-face personal interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). Associations between specific mood and anxiety disorders and specific drug use disorders were virtually all positive and statistically significant (p<.05). In general, associations were greater for dependence than abuse, greater for mood than anxiety disorders, and in some instances stronger among women than men (p<.05). Large odds ratios also were observed for individuals with comorbid mood and anxiety disorders. The comorbidity between specific mood and anxiety disorders and specific drug use disorders is pervasive in the U.S. population. Findings suggest that comorbid psychiatric disorders may increase the risk of greater involvement in more serious illicit drug use disorders and that the greater comorbidity between mood and anxiety and drug use disorders among women may reflect greater deviance and psychopathology among drug-using women than men. Findings also suggest that drug abuse prevention and intervention efforts should address other psychiatric conditions. Further, definitions of drug use disorder phenotypes should give careful consideration to other psychiatric conditions as meaningful characteristics of case heterogeneity. JF - The Journal of clinical psychiatry AU - Conway, Kevin P AU - Compton, Wilson AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 247 EP - 257 VL - 67 IS - 2 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Regression Analysis KW - Sex Factors KW - Alcoholism -- diagnosis KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Comorbidity KW - Depressive Disorder -- epidemiology KW - Psychiatric Status Rating Scales KW - Alcoholism -- epidemiology KW - Adult KW - Health Surveys KW - Depressive Disorder -- diagnosis KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Mood Disorders -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67804562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Lifetime+comorbidity+of+DSM-IV+mood+and+anxiety+disorders+and+specific+drug+use+disorders%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Conway%2C+Kevin+P%3BCompton%2C+Wilson%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2006-02-01&rft.volume=67&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Ment Health. 2006 Nov;9(4):113 [17065310] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postmarketing surveillance of suicidal adverse events with pediatric use of antidepressants. AN - 67779637; 16553527 AB - The aim of this analysis was to delineate trends in spontaneous postmarketing reporting data with antidepressant drugs for adverse events involving suicidal behaviors in children and adolescents. The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) was searched for postmarketing adverse event reports of suicidal thoughts and behaviors occurring in children and adolescents treated with 10 antidepressant drugs. The search covered the period from market launch of each drug through November 2003. A total of 524 reports were returned by the search. All drugs had reports, and most drugs demonstrated 15 or fewer reports annually, with the following two exceptions. We observed a peak of reporting for fluoxetine in the early 1990s, and another peak of reporting for paroxetine in recent years. Further investigation revealed that the peak in recent paroxetine reporting was accounted for by reports from consumers, whereas reporting by health professionals remained fairly constant. In contrast, the earlier peak in reports for fluoxetine was not accounted for by an increase in consumer reporting. Spontaneous reporting data for suicidal events in pediatric patients treated with antidepressant drugs appears to be highly variable and subject to various influences. The most appropriate method to assess an association of antidepressant drug treatment with suicidal behaviors is examination of systematically collected data with appropriate comparison groups, such as randomized, controlled trial data. JF - Journal of child and adolescent psychopharmacology AU - Mosholder, Andrew D AU - Pamer, Carol A AD - Division of Drug Risk Evaluation, Office of Drug Safety, U.S. Food and Drug Administration, Rockville, Maryland 20993, USA. andrew.mosholder@fda.hhs.gov PY - 2006 SP - 33 EP - 36 VL - 16 IS - 1-2 SN - 1044-5463, 1044-5463 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - United States KW - Mental Disorders -- epidemiology KW - Mental Disorders -- drug therapy KW - Humans KW - Child KW - Adolescent KW - United States Food and Drug Administration -- trends KW - Suicide -- trends KW - Adverse Drug Reaction Reporting Systems -- trends KW - Antidepressive Agents -- adverse effects KW - Product Surveillance, Postmarketing -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67779637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Postmarketing+surveillance+of+suicidal+adverse+events+with+pediatric+use+of+antidepressants.&rft.au=Mosholder%2C+Andrew+D%3BPamer%2C+Carol+A&rft.aulast=Mosholder&rft.aufirst=Andrew&rft.date=2006-02-01&rft.volume=16&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicidal adverse events in pediatric randomized, controlled clinical trials of antidepressant drugs are associated with active drug treatment: a meta-analysis. AN - 67777876; 16553526 AB - The aim of this study was to compare the incidence of suicidal ideation and behaviors observed with antidepressant drug treatment to the incidence with placebo, in randomized, controlled pediatric clinical trials. Manufacturers of nine antidepressant drugs identified suicidal adverse events in randomized, placebo-controlled, pediatric clinical trials that they had sponsored. Events were found with an electronic search for adverse event descriptions, including key words suggesting suicidal ideation or self-injury, along with a manual review of all adverse events meeting the standard regulatory definition for seriousness. Incidence rate data for these events supplied by the manufacturers were combined across trials to yield Mantel-Haenszel combined risk estimates. Data from 22 randomized, short-term, placebo-controlled, pediatric trials in various indications, involving nine different antidepressant drugs, were available for analysis. A total of 2298 pediatric subjects were exposed to active drug, and 1952 to placebo. Seventy eight (78) serious suicidal adverse events occurred in these trials (54 with active drug and 24 with placebo); there were no completed suicides. The combined incidence rate ratio across all trials for serious suicidal adverse events was 1.89 (95% Confidence Interval, 1.18-3.04). In short-term, placebo-controlled, pediatric studies of antidepressants, active drug treatment was associated with a rate of serious suicidal events almost twice that of placebo. JF - Journal of child and adolescent psychopharmacology AU - Mosholder, Andrew D AU - Willy, Mary AD - Division of Drug Risk Evaluation, Office of Drug Safety, U.S. Food and Drug Administration, Rockville, Maryland 20993, USA. andrew.mosholder@fda.hhs.gov PY - 2006 SP - 25 EP - 32 VL - 16 IS - 1-2 SN - 1044-5463, 1044-5463 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Mental Disorders -- epidemiology KW - Mental Disorders -- drug therapy KW - Humans KW - Mental Disorders -- psychology KW - Child KW - Adolescent KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted -- psychology KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67777876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Suicidal+adverse+events+in+pediatric+randomized%2C+controlled+clinical+trials+of+antidepressant+drugs+are+associated+with+active+drug+treatment%3A+a+meta-analysis.&rft.au=Mosholder%2C+Andrew+D%3BWilly%2C+Mary&rft.aulast=Mosholder&rft.aufirst=Andrew&rft.date=2006-02-01&rft.volume=16&rft.issue=1-2&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residential insecticide use and risk of non-Hodgkin's lymphoma. AN - 67682432; 16492912 AB - Previous studies have linked non-Hodgkin's lymphoma (NHL) with occupational exposure to insecticides, but residential use is largely unexplored. In this population-based case-control study, we examined NHL risk and use of insecticides in the home and garden. We identified NHL cases, uninfected with HIV, diagnosed between 1998 and 2000 among women and men ages 20 to 74 years in Iowa and the metropolitan areas of Los Angeles, Detroit, and Seattle. Controls were selected using random digit dialing or Medicare files. Computer-assisted personal interviews (1,321 cases and 1,057 controls) elicited data on insecticide use at each home occupied since 1970. Insecticide levels were measured in dust taken from used vacuum cleaner bags (682 cases and 513 controls). We previously reported a positive association with dichlorodiphenyldichloroethylene levels in carpet dust residues. Here, we focus on insecticides that were commonly used after 1970, the time period covered by our questionnaire. People whose homes were treated for termites had elevated NHL risk (odds ratio, 1.3; 95% confidence interval, 1.0-1.6). Risk was modestly, although not significantly, elevated in all but one study center and in all sexes and races. The elevation in risk was restricted to people whose homes were treated before the 1988 chlordane ban. There was a significant trend of increasing risk with increasing levels of alpha-chlordane residues in dust (P(trend) = 0.04) and a marginally significant trend for gamma-chlordane (P(trend) = 0.06). We found no evidence of associations for insects overall, for specific types of insects other than termites, or for elevated residues of other insecticides. We concluded that chlordane treatment of homes for termites may increase residents' NHL risk. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Colt, Joanne S AU - Davis, Scott AU - Severson, Richard K AU - Lynch, Charles F AU - Cozen, Wendy AU - Camann, David AU - Engels, Eric A AU - Blair, Aaron AU - Hartge, Patricia AD - Occupational and Environmental Epidemiology Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20852, USA. coltj@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 251 EP - 257 VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - Dust KW - 0 KW - Environmental Pollutants KW - Insecticides KW - Chlordan KW - 12789-03-6 KW - Index Medicus KW - Animals KW - Dust -- analysis KW - Humans KW - Aged KW - Risk Assessment KW - Floors and Floorcoverings KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - Female KW - Male KW - Isoptera KW - Insecticides -- toxicity KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Chlordan -- toxicity KW - Environmental Pollutants -- toxicity KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67682432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Residential+insecticide+use+and+risk+of+non-Hodgkin%27s+lymphoma.&rft.au=Colt%2C+Joanne+S%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BLynch%2C+Charles+F%3BCozen%2C+Wendy%3BCamann%2C+David%3BEngels%2C+Eric+A%3BBlair%2C+Aaron%3BHartge%2C+Patricia&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of Shiga toxin genes stx1, stx2, and the +93 uidA mutation of E. coli O157:H7/H-using SYBR Green I in a real-time multiplex PCR. AN - 67681660; 16271448 AB - Enterohemorrhagic Escherichia coli (EHEC) is a major foodborne pathogen capable of causing diarrhea and vomiting, but more serious complications such as hemorrhagic colitis and hemolytic-uremic syndrome (HUS) can result. A real-time PCR method to detect the presence of Shiga toxin producing E. coli (STEC) and E. coli O157:H7 was investigated using SYBR Green I (SG). Primers were designed to target the Shiga toxin genes (stx1 and stx2) and a highly conserved base substitution at +93 of the beta-glucuronidase gene (uidA) unique to E. coli O157:H7. An initial test panel of five E. coli and non-E. coli isolates was tested with individual primer sets (simplex assay) and all primer sets including stx1, stx2, and uidA (multiplex assay). All strains were correctly identified in both assays. Average melt temperatures (Tm's, degrees C) for PCR products were 85.42--stx1, 81.93--stx2, and 88.25--uidA in simplex assays and 85.20--stx1, 81.20--stx2, and 88.16--uidA when multiplexed. Each of the three gene targets in one multiplex reaction could be distinguished by melt curve data with significantly different Tm's. The assay was expanded to a panel of 138 isolates consisting of STEC, E. coli O157:H7, non-toxigenic E. coli, and non-E. coli isolates with melt peaks consistent with those stated above. JF - Molecular and cellular probes AU - Yoshitomi, Ken J AU - Jinneman, Karen C AU - Weagant, Stephen D AD - Seafood Products Research Center, US Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021-4421, USA. ken.yoshitomi@fda.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 31 EP - 41 VL - 20 IS - 1 SN - 0890-8508, 0890-8508 KW - Fluorescent Dyes KW - 0 KW - Organic Chemicals KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - SYBR Green I KW - 163795-75-3 KW - Index Medicus KW - Genotype KW - Nucleic Acid Denaturation KW - Humans KW - Mutation KW - Shiga Toxin 2 -- genetics KW - Fluorescent Dyes -- metabolism KW - Escherichia coli O157 -- chemistry KW - Shiga Toxin 2 -- analysis KW - Organic Chemicals -- metabolism KW - Polymerase Chain Reaction -- methods KW - Shiga Toxin 1 -- analysis KW - Shiga Toxin 1 -- genetics KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67681660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+probes&rft.atitle=Detection+of+Shiga+toxin+genes+stx1%2C+stx2%2C+and+the+%2B93+uidA+mutation+of+E.+coli+O157%3AH7%2FH-using+SYBR+Green+I+in+a+real-time+multiplex+PCR.&rft.au=Yoshitomi%2C+Ken+J%3BJinneman%2C+Karen+C%3BWeagant%2C+Stephen+D&rft.aulast=Yoshitomi&rft.aufirst=Ken&rft.date=2006-02-01&rft.volume=20&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+probes&rft.issn=08908508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. AN - 67679147; 16492928 AB - Impaired base-excision repair (BER) function can give rise to the accumulation of DNA damage and initiation of cancer. We evaluated whether genetic variation in six BER pathway genes (XRCC1, ADPRT, APEX1, OGG1, LIG3, and MUTYH) is associated with breast cancer risk in two large population-based case-control studies in the United States (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls). A detailed evaluation was first done in a subset of 1,898 cases and 1,514 controls with mouthwash DNA samples in the U.S. study. Significant findings were followed up in the remainder of the U.S. study population that provided cytobrush DNA samples and in the Polish study. Using data from U.S. study participants with mouthwash DNA, we found no significant overall association between breast cancer risk and XRCC1 R280H and R194W, ADPRT V726W, APEX1 D148E, OGG1 S326C, LIG3 R780H, or MUTYH 5' untranslated region. These data suggested a decreased risk for XRCC1Q399R homozygous variants compared with homozygous wild-type in premenopausal women, but these findings were not confirmed when data from cytobrush DNA samples were added [combined odds ratio (OR), 0.8; 95% confidence interval (95% CI), 0.6-1.1] or in the Polish study (OR, 1.0; 95% CI, 0.7-1.5). Meta-analyses based on our data and published data from studies of two single nucleotide polymorphisms in XRCC1 showed no evidence of an overall association between breast cancer risk and homozygous variants versus wild-type for Q399R (OR, 1.1; 95% CI, 1.0-1.2) or R194W (OR, 1.0; 95% CI, 0.7-1.8), although there was a suggestion for an association in Asian populations for Q399R (OR, 1.6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Zhang, Yawei AU - Newcomb, Polly A AU - Egan, Kathleen M AU - Titus-Ernstoff, Linda AU - Chanock, Stephen AU - Welch, Robert AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Bardin-Mikolajczak, Alicja AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA. yawei.zhang@yale.edu Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 353 EP - 358 VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - DNA-Binding Proteins KW - 0 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - United States KW - DNA Damage KW - Premenopause KW - Humans KW - DNA-Binding Proteins -- genetics KW - Aged KW - Genotype KW - Risk KW - Postmenopause KW - DNA Repair Enzymes -- genetics KW - Poland KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Genetic+polymorphisms+in+base-excision+repair+pathway+genes+and+risk+of+breast+cancer.&rft.au=Zhang%2C+Yawei%3BNewcomb%2C+Polly+A%3BEgan%2C+Kathleen+M%3BTitus-Ernstoff%2C+Linda%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BBardin-Mikolajczak%2C+Alicja%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BGarcia-Closas%2C+Montserrat&rft.aulast=Zhang&rft.aufirst=Yawei&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circular dichroism and cross-linking studies of bacteriorhodopsin mutants. AN - 67670154; 16477391 AB - Circular dichroism (CD) spectroscopy was employed for native (wild type, WT) bacteriorhodopsin (bR) and several mutant derivatives: R134K, R134H, R82Q, S35C, L66C, and R134C/E194C. Comparative analysis of the CD spectra in visible range shows that only R134C/E194C exhibits biphasic CD, typical for native bR, the other mutants demonstrate CD spectra with significantly smaller or absent negative band. Since the biphasic CD is a feature of hexagonal lattice structure composed by bR trimers in the purple membrane, these mutants and WT were examined by cross-linking studies, which confirmed the same trend towards trimeric organization. Therefore, a single amino acid substitution may lead to drastically different CD spectra without disruption of bR trimeric organization. Thus, although disruption of bR trimeric crystalline lattice structure (e.g., solubilization with detergents) directly results in the disappearance of characteristic bilobe in visible CD, the lack of the bilobe in the CD alone does not predict the absence of trimers. JF - Amino acids AU - Karnaukhova, E AU - Schey, K L AU - Crouch, R K AD - Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. karnaukhova@cber.fda.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 17 EP - 23 VL - 30 IS - 1 SN - 0939-4451, 0939-4451 KW - Cross-Linking Reagents KW - 0 KW - Bacteriorhodopsins KW - 53026-44-1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Halobacterium salinarum -- genetics KW - Circular Dichroism KW - Amino Acid Substitution KW - Halobacterium salinarum -- chemistry KW - Bacteriorhodopsins -- chemistry KW - Bacteriorhodopsins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67670154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amino+acids&rft.atitle=Circular+dichroism+and+cross-linking+studies+of+bacteriorhodopsin+mutants.&rft.au=Karnaukhova%2C+E%3BSchey%2C+K+L%3BCrouch%2C+R+K&rft.aulast=Karnaukhova&rft.aufirst=E&rft.date=2006-02-01&rft.volume=30&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Amino+acids&rft.issn=09394451&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice. AN - 67668160; 16485898 AB - Drug-induced liver disease (DILD) continues to cause significant morbidity and mortality and impair new drug development. Mounting evidence suggests that DILD is a complex, multifactorial disease in which no one factor is likely to be an absolute indicator of susceptibility. As an approach to better understand the multifactorial basis of DILD, we recently compared the hepatic proteomes of mice that were resistant (SJL) and susceptible (C57Bl/6) to APAP-induced liver disease (AILD) wherein we identified potential risk factors and mechanistic pathways responsible for DILD. In this study, we have uncovered additional potential risk factors by comparing hepatic mRNA expression profiles of the same two strains of mice with that of SJLxB6-F1 hybrid (F1) mice, which were found to be of intermediate susceptibility to AILD. Global hepatic gene expression profiling over a 24 h period following APAP treatment revealed elevated patterns in the mRNA expression of cytoprotective genes in resistant SJL mice as compared to susceptible B6 mice, while F1 mice had intermediate mRNA expression levels of these genes. One of these genes encoded for heat shock protein (HSP) 70 whose relative protein expression among the three strains of mice was found to parallel that of their mRNA levels, suggesting that this protein had a protective role against AILD. However, there was no difference in the susceptibility of HSP70 knockout (KO) mice to AILD as compared to wild-type (WT) mice. There were also protoxicant genes, such as osteopontin (OPN), with elevated mRNA expression levels in the B6 mice as compared to the SJL mice and with intermediate levels in the F1 mice, suggesting that they may play a role in exacerbating liver injury after APAP treatment. In support of this hypothesis, OPN KO mice were found to be more resistant to AILD than WT mice. Additionally, the results from both the proteomic and the genomic studies were compared. The two approaches were found to be complementary to each other and not simply overlapping. Our findings suggest that comparative gene expression analysis of susceptible and resistant mouse strains may lead to the identification of factors that could have a role in determining the susceptibility of individuals to DILD. JF - Chemical research in toxicology AU - Welch, Kevin D AU - Reilly, Timothy P AU - Bourdi, Mohammed AU - Hays, Thomas AU - Pise-Masison, Cynthia A AU - Radonovich, Michael F AU - Brady, John N AU - Dix, David J AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. WelchKD@nhlbi.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 223 EP - 233 VL - 19 IS - 2 SN - 0893-228X, 0893-228X KW - HSP70 Heat-Shock Proteins KW - 0 KW - RNA, Messenger KW - Sialoglycoproteins KW - Spp1 protein, mouse KW - Osteopontin KW - 106441-73-0 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Liver -- pathology KW - Sialoglycoproteins -- genetics KW - Liver -- metabolism KW - Mice KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis KW - Mice, Knockout KW - Mice, Inbred Strains KW - Risk Factors KW - Sialoglycoproteins -- biosynthesis KW - Mice, Inbred C57BL KW - Gene Expression Regulation KW - HSP70 Heat-Shock Proteins -- deficiency KW - Time Factors KW - Chemical and Drug Induced Liver Injury KW - Acetaminophen -- chemistry KW - Genetic Predisposition to Disease KW - Liver Diseases -- genetics KW - Acetaminophen -- toxicity KW - Liver Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67668160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Genomic+identification+of+potential+risk+factors+during+acetaminophen-induced+liver+disease+in+susceptible+and+resistant+strains+of+mice.&rft.au=Welch%2C+Kevin+D%3BReilly%2C+Timothy+P%3BBourdi%2C+Mohammed%3BHays%2C+Thomas%3BPise-Masison%2C+Cynthia+A%3BRadonovich%2C+Michael+F%3BBrady%2C+John+N%3BDix%2C+David+J%3BPohl%2C+Lance+R&rft.aulast=Welch&rft.aufirst=Kevin&rft.date=2006-02-01&rft.volume=19&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. AN - 67654777; 16474263 AB - After investigating fixed airways obstruction in butter flavoring-exposed workers at a microwave popcorn plant, we sought to further characterize lung disease risk from airborne butter-flavoring chemicals. We analyzed data from medical and environmental surveys at six microwave popcorn plants (including the index plant). Respiratory symptom and airways obstruction prevalences were higher in oil and flavorings mixers with longer work histories and in packaging-area workers near nonisolated tanks of oil and flavorings. Workers were affected at five plants, one with mixing-area exposure to diacetyl (a butter-flavoring chemical with known respiratory toxicity potential) as low as 0.02 ppm. Microwave popcorn workers at many plants are at risk for flavoring-related lung disease. Peak exposures may be hazardous even when ventilation maintains low average exposures. Respiratory protection and engineering controls are necessary to protect workers. JF - Journal of occupational and environmental medicine AU - Kanwal, Richard AU - Kullman, Greg AU - Piacitelli, Chris AU - Boylstein, Randy AU - Sahakian, Nancy AU - Martin, Stephen AU - Fedan, Kathleen AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA. rkanwal@cdc.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 149 EP - 157 VL - 48 IS - 2 SN - 1076-2752, 1076-2752 KW - Air Pollutants, Occupational KW - 0 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - Humans KW - Health Surveys KW - Adult KW - Aged KW - Middle Aged KW - Occupations KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Prevalence KW - Occupational Exposure -- prevention & control KW - Diacetyl -- analysis KW - Lung Diseases, Obstructive -- chemically induced KW - Air Pollutants, Occupational -- analysis KW - Diacetyl -- adverse effects KW - Air Pollutants, Occupational -- adverse effects KW - Occupational Exposure -- adverse effects KW - Food-Processing Industry KW - Lung Diseases, Obstructive -- epidemiology KW - Occupational Exposure -- analysis KW - Lung Diseases, Obstructive -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67654777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Evaluation+of+flavorings-related+lung+disease+risk+at+six+microwave+popcorn+plants.&rft.au=Kanwal%2C+Richard%3BKullman%2C+Greg%3BPiacitelli%2C+Chris%3BBoylstein%2C+Randy%3BSahakian%2C+Nancy%3BMartin%2C+Stephen%3BFedan%2C+Kathleen%3BKreiss%2C+Kathleen&rft.aulast=Kanwal&rft.aufirst=Richard&rft.date=2006-02-01&rft.volume=48&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization and chronic beryllium disease among workers in copper-beryllium distribution centers. AN - 67652755; 16474270 AB - Little is known about the risk of sensitization and chronic beryllium disease (CBD) among workers performing limited processing of copper-beryllium alloys downstream of the primary beryllium industry. In this study, we performed a cross-sectional survey of employees at three copper-beryllium alloy distribution centers. One hundred workers were invited to be tested for beryllium sensitization using the beryllium blood lymphocyte proliferation test (BeLPT); a sensitized worker was further evaluated for CBD. Available beryllium mass concentration air sampling data were obtained for characterization of airborne exposure. One participant, who had exposure to other forms of beryllium, was found to be sensitized and to have CBD, resulting in a prevalence of sensitization/CBD of 1% for all tested. The overall prevalence of beryllium sensitization and CBD for workers in these three copper-beryllium alloy distribution centers is lower than for workers in primary beryllium production facilities. JF - Journal of occupational and environmental medicine AU - Stanton, Marcia L AU - Henneberger, Paul K AU - Kent, Michael S AU - Deubner, David C AU - Kreiss, Kathleen AU - Schuler, Christine R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505, USA. mstanton@cdc.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 204 EP - 211 VL - 48 IS - 2 SN - 1076-2752, 1076-2752 KW - Air Pollutants, Occupational KW - 0 KW - Alloys KW - Copper KW - 789U1901C5 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Occupations KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Air Pollutants, Occupational -- analysis KW - Respiratory Hypersensitivity -- epidemiology KW - Air Pollutants, Occupational -- adverse effects KW - Berylliosis -- epidemiology KW - Beryllium -- adverse effects KW - Beryllium -- analysis KW - Berylliosis -- pathology KW - Respiratory Hypersensitivity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67652755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Sensitization+and+chronic+beryllium+disease+among+workers+in+copper-beryllium+distribution+centers.&rft.au=Stanton%2C+Marcia+L%3BHenneberger%2C+Paul+K%3BKent%2C+Michael+S%3BDeubner%2C+David+C%3BKreiss%2C+Kathleen%3BSchuler%2C+Christine+R&rft.aulast=Stanton&rft.aufirst=Marcia&rft.date=2006-02-01&rft.volume=48&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FEV6 as a surrogate for FVC in detecting airways obstruction and restriction in the workplace. AN - 67625288; 16452595 AB - Compared with measurements of forced vital capacity (FVC), using the forced expiratory volume in six seconds (FEV(6)) reduces test time and frustration. It was hypothesised that using FEV(6) in the workplace setting would result in an acceptably low misclassification rate for detecting airways obstruction and spirometry-defined restriction when compared with using the traditional FVC. Experienced technicians from the National Institute for Occupational Safety and Health performed spirometry using dry rolling-seal spirometers as per American Thoracic Society guidelines in four workplace investigations. Airways obstruction was defined as an FEV(1)/FVC % below the lower limit of normal (LLN) using National Health and Nutrition Examination Survey III reference equations. Restriction was defined as an FVC below the LLN with a normal FEV(1)/FVC %. These "gold standard" definitions were compared with definitions based on FEV(6) (obstruction: FEV(1)/FEV(6) below the LLN; restriction: FEV(6) below the LLN with a normal FEV(1)/FEV(6)). The median (range) age of the 1,139 workers was 37 yrs (18-71 yrs) and 51.4% were male. A significantly high overall agreement was obtained between the two definitions. In conclusion, the current results confirm that forced expiratory volume in six seconds can be used as a surrogate for forced vital capacity in detecting airways obstruction and restriction in workers, although with some misclassification when compared to obtaining American Thoracic Society-acceptable manoeuvres of longer duration. JF - The European respiratory journal AU - Akpinar-Elci, M AU - Fedan, K B AU - Enright, P L AD - Centers for Disease Control and Prevention (CDC)/National Institute for Occupational Safety and Health (NIOSH), Division of Respiratory Disease Studies, Morgantown, WV 26505, USA. melci@cdc.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 374 EP - 377 VL - 27 IS - 2 SN - 0903-1936, 0903-1936 KW - Index Medicus KW - Sensitivity and Specificity KW - Respiratory Function Tests KW - Spirometry KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Airway Obstruction -- physiopathology KW - Vital Capacity KW - Airway Obstruction -- diagnosis KW - Occupational Diseases -- physiopathology KW - Workplace KW - Forced Expiratory Volume UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67625288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+respiratory+journal&rft.atitle=FEV6+as+a+surrogate+for+FVC+in+detecting+airways+obstruction+and+restriction+in+the+workplace.&rft.au=Akpinar-Elci%2C+M%3BFedan%2C+K+B%3BEnright%2C+P+L&rft.aulast=Akpinar-Elci&rft.aufirst=M&rft.date=2006-02-01&rft.volume=27&rft.issue=2&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=The+European+respiratory+journal&rft.issn=09031936&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-05 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway. AN - 67616455; 16169898 AB - Crystalline silica has long been well established as a fibrogenic agent, and recent evidence has implicated it as a potential human carcinogen. However, the mechanisms of silica-induced disease development and progression are not well understood. Our previous studies demonstrated that crystalline silica is able to activate activator protein-1 (AP-1) through mitogen-activated protein kinase (MAPK) pathways. The present study investigates the possible involvement of protein kinase C (PKC) in silica-induced activation of the MAPK/AP-1 signal transduction pathway. Treatment of mouse epidermal cells (JB6 cell line) with freshly fractured silica stimulated translocation of PKCalpha and PKCepsilon from the cytosol to the membrane and activated AP-1 transcription activity. Pretreatment of cells with PKC inhibitors, including RO-32-0432, calphostin C, and bisindolylmaleimide I, inhibited silica-induced AP-1 activation and phosphorylation of ERKs and p38 kinase. These inhibitory effects by PKC inhibitors were dose dependent. Furthermore, overexpression of dominant negative mutant (DNM) of PKCalpha or PKCepsilon markedly blocked AP-1 activation as well as phosphorylation of ERKs and p38 kinase induced by freshly fractured silica. These results demonstrate that PKCalpha and PKCepsilon are essential in silica-induced AP-1 activation through the MAP kinase (ERKs and p38 kinases) pathway. JF - American journal of physiology. Lung cellular and molecular physiology AU - Ding, Min AU - Huang, Chuanshu AU - Lu, Yongju AU - Bowman, Linda AU - Castranova, Vince AU - Vallyathan, Val AD - Pathology and Physiology Research Branch, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA. mid5@cdc.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - L291 EP - L297 VL - 290 IS - 2 SN - 1040-0605, 1040-0605 KW - Enzyme Inhibitors KW - 0 KW - Indoles KW - Maleimides KW - Naphthalenes KW - Pyrroles KW - Transcription Factor AP-1 KW - Ro 32-0432 KW - 151342-35-7 KW - Silicon Dioxide KW - 7631-86-9 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C-alpha KW - Protein Kinase C-epsilon KW - calphostin C KW - I271P23G24 KW - bisindolylmaleimide I KW - L79H6N0V6C KW - Index Medicus KW - Crystallization KW - Naphthalenes -- pharmacology KW - Animals KW - Enzyme Activation KW - Protein Transport -- drug effects KW - Mice KW - Pyrroles -- pharmacology KW - Protein Kinase C-alpha -- metabolism KW - Protein Kinase C-epsilon -- metabolism KW - Transfection KW - Enzyme Inhibitors -- pharmacology KW - Indoles -- pharmacology KW - Cell Line KW - Maleimides -- pharmacology KW - Silicon Dioxide -- pharmacology KW - MAP Kinase Signaling System -- drug effects KW - Protein Kinase C -- antagonists & inhibitors KW - MAP Kinase Signaling System -- physiology KW - Protein Kinase C -- genetics KW - Transcription Factor AP-1 -- drug effects KW - Protein Kinase C -- physiology KW - Transcription Factor AP-1 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67616455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=Involvement+of+protein+kinase+C+in+crystalline+silica-induced+activation+of+the+MAP+kinase+and+AP-1+pathway.&rft.au=Ding%2C+Min%3BHuang%2C+Chuanshu%3BLu%2C+Yongju%3BBowman%2C+Linda%3BCastranova%2C+Vince%3BVallyathan%2C+Val&rft.aulast=Ding&rft.aufirst=Min&rft.date=2006-02-01&rft.volume=290&rft.issue=2&rft.spage=L291&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Small businesses with high fatality rates: assessment of hazards and their prevention. AN - 67607824; 16396827 JF - Journal of occupational and environmental hygiene AU - Lentz, T J AU - Wenzl, T B AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - D8 EP - 14 VL - 3 IS - 2 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Education KW - Humans KW - Safety KW - Data Collection KW - Risk Assessment KW - Commerce KW - Accidents, Occupational -- mortality KW - Accident Prevention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67607824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Small+businesses+with+high+fatality+rates%3A+assessment+of+hazards+and+their+prevention.&rft.au=Lentz%2C+T+J%3BWenzl%2C+T+B&rft.aulast=Lentz&rft.aufirst=T&rft.date=2006-02-01&rft.volume=3&rft.issue=2&rft.spage=D8&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-04 N1 - Date created - 2006-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection. AN - 67604960; 16392079 AB - Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection. Implicating RZ as the likeliest cause required excluding alternative causes. US health departments reported data on patients who died or were hospitalized for liver disease within 1 month after taking RZ for latent tuberculosis infection from October 1998 through March 2004. The circumstances were investigated on site for each case. Illness characteristics, reasons for RZ treatment, doses and frequency of administration of pyrazinamide, monitoring during treatment, and causes of liver injury were determined. Liver injury was attributable to RZ use for all 50 patients reported, 12 of whom died. For 47 patients, RZ was the likeliest cause of liver injury. The median patient age was 44 years (range, 17-73 years). Thirty-two patients (64%) were male. Seven (16%) of 43 patients tested had hepatitis C virus antibodies, 1 (2%) of 45 had chronic hepatitis B, 3 (14%) of 22 had positive results of HIV serologic tests, 34 (71%) of 48 had alcohol use noted, and 33 (66%) of 50 were taking additional hepatotoxic medications. Six patients, 2 of whom died, had no predictors for liver disease. Patients who died were older (median age, 52 vs. 42 years; P=.08) and took a greater number of other medications (median number of medications, 4 vs. 2; P=.05) than did those who recovered, but these 2 factors were correlated (P<.01). Thirty-one patients (62%) were monitored according to guidelines, 9 of whom died. RZ was the likeliest cause of most of these liver injuries, some of which were fatal in spite of monitoring. Fatality was predicted by age or use of other medications, but none of the cofactors showed promise as a reliable clinical predictor of severe liver injury. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Ijaz, Kashef AU - Jereb, John A AU - Lambert, Lauren A AU - Bower, William A AU - Spradling, Philip R AU - McElroy, Peter D AU - Iademarco, Michael F AU - Navin, Thomas R AU - Castro, Kenneth G AD - Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA. kijaz@cdc.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 346 EP - 355 VL - 42 IS - 3 KW - Antitubercular Agents KW - 0 KW - Pyrazinamide KW - 2KNI5N06TI KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - United States KW - Drug Administration Schedule KW - Risk Factors KW - Humans KW - Adult KW - Substance-Related Disorders KW - Aged KW - Middle Aged KW - Antitubercular Agents -- adverse effects KW - Alcohol Drinking KW - Adolescent KW - Male KW - Female KW - Antitubercular Agents -- therapeutic use KW - Pyrazinamide -- adverse effects KW - Chemical and Drug Induced Liver Injury -- mortality KW - Tuberculosis -- drug therapy KW - Rifampin -- adverse effects KW - Pyrazinamide -- administration & dosage KW - Rifampin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67604960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Severe+or+fatal+liver+injury+in+50+patients+in+the+United+States+taking+rifampin+and+pyrazinamide+for+latent+tuberculosis+infection.&rft.au=Ijaz%2C+Kashef%3BJereb%2C+John+A%3BLambert%2C+Lauren+A%3BBower%2C+William+A%3BSpradling%2C+Philip+R%3BMcElroy%2C+Peter+D%3BIademarco%2C+Michael+F%3BNavin%2C+Thomas+R%3BCastro%2C+Kenneth+G&rft.aulast=Ijaz&rft.aufirst=Kashef&rft.date=2006-02-01&rft.volume=42&rft.issue=3&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-10 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bromocriptine treatment for cocaine addiction: association with plasma prolactin levels. AN - 67590978; 16051446 AB - Bromocriptine is a dopamine receptor agonist used with mixed success in the treatment of cocaine addiction. Variations in dopamine receptor sensitivity may help account for these differences. We evaluated this question in a 24-week outpatient controlled clinical trial in 70 cocaine-abusing (DSM-III) men (86% African-American, mean age 34 years, mean 39 months of regular cocaine use [predominantly smoked]). Subjects received 4 weeks of inpatient treatment. During the last 2 weeks they were inducted onto bromocriptine (maximum dose 2.5mg po tid) (n=35) or placebo (n=35). Plasma prolactin concentrations were assayed before and after the first bromocriptine dose (1.25mg po) as a measure of dopamine receptor sensitivity. After discharge, subjects continued on medication with weekly group counseling. Bromocriptine significantly suppressed prolactin concentrations (4.4 ng/ml decrease), while placebo did not (0.1 ng/ml decrease). Both groups decreased their cocaine use, with no significant group differences in retention in treatment or proportion of cocaine-positive urine samples. There was no significant association between basal plasma prolactin concentrations or prolactin response to first bromocriptine dose and either outcome measure. These data do not support the efficacy of bromocriptine treatment nor a role for prolactin concentration in predicting treatment response. JF - Drug and alcohol dependence AU - Gorelick, David A AU - Wilkins, Jeffery N AD - Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. dgorelick@intra.nida.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 189 EP - 195 VL - 81 IS - 2 SN - 0376-8716, 0376-8716 KW - Dopamine Agonists KW - 0 KW - Bromocriptine KW - 3A64E3G5ZO KW - Prolactin KW - 9002-62-4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Outpatients KW - Prolactin -- blood KW - Double-Blind Method KW - Patient Compliance KW - Humans KW - Male KW - Dopamine Agonists -- therapeutic use KW - Bromocriptine -- therapeutic use KW - Cocaine-Related Disorders -- therapy KW - Cocaine-Related Disorders -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67590978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Bromocriptine+treatment+for+cocaine+addiction%3A+association+with+plasma+prolactin+levels.&rft.au=Gorelick%2C+David+A%3BWilkins%2C+Jeffery+N&rft.aulast=Gorelick&rft.aufirst=David&rft.date=2006-02-01&rft.volume=81&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preventable Hospitalization and Medicaid Managed Care: Does Race Matter? AN - 59992839; 200613699 AB - This study examines the preventable hospitalization patterns of Medicaid patients by race/ethnicity to determine whether Medicaid managed care (MMC) has been more effective in some subgroups than others. It uses logistic models for three states, comparing preventable hospitalizations with marker admissions (urgent admissions, insensitive to primary care). Hospital discharge data from the Healthcare Cost & Utilization Project State Inpatient database of the Agency for Health Care Research & Quality for New York, Pennsylvania, & Wisconsin residents aged 20-64 years is used. In a more urban state, New York, MMC was effective for Whites but not for minorities. In a more rural state, Wisconsin, MMC was effective for minorities. Overall, the evidence is not strong that any particular racial group consistently benefited from MMC, or that any state consistently showed a favorable impact of MMC across racial groups. However, racial/ethnic disparity associated with the risk of preventable hospitalization is significantly lower among Medicaid patients than among private fee-for-service patients. Tables. [Reprinted by permission of Sage Publications Inc., copyright 2006.] JF - Journal of Health Care for the Poor and Underserved AU - Basu, Jayasree AU - Friedman, Bernard AU - Burstin, Helen Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 101 EP - 115 PB - John Hopkins U Press, Baltimore MD VL - 17 IS - 1 SN - 1049-2089, 1049-2089 KW - Preventable hospitalization, ambulatory care sensitive conditions, Medicaid, managed care, racial disparity KW - Rural Urban Differences KW - Medicaid KW - Racial Differences KW - Health Care Costs KW - Whites KW - New York KW - Prevention KW - Managed Care Services KW - Hospitalization KW - Cost Containment KW - Wisconsin KW - Pennsylvania KW - Health Care Utilization KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59992839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Preventable+Hospitalization+and+Medicaid+Managed+Care%3A+Does+Race+Matter%3F&rft.au=Basu%2C+Jayasree%3BFriedman%2C+Bernard%3BBurstin%2C+Helen&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2006-02-01&rft.volume=17&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Medicaid; Hospitalization; Prevention; Racial Differences; Health Care Utilization; Managed Care Services; Cost Containment; Health Care Costs; New York; Pennsylvania; Wisconsin; Whites; Rural Urban Differences ER - TY - JOUR T1 - Standing support alternatives in Western United States longwalls AN - 51599458; 2006-031617 AB - Mines in the western United States have had limited choices for standing support. Wood cribs were often too soft and unstable. The introduction of the Can support in the early 1990s provided an effective alternative, and it remains the dominant form of tailgate support. Water-filled prestressing cells are now used to cap the Can and preload it to provide an active roof load. The Cluster Prop, consisting of three timber wedge props bundled together, provides more capacity than an equivalent sized Can support and improves transport efficiency. However, the Cluster Prop is less stable and does not maintain a consistent load throughout its loading profile. Pumpable roof supports are another alternative support, but they have not been proven in high deformation environments. This paper compares the performance characteristics of these various support systems. JF - Mining Engineering AU - Barczak, T M AU - Tadolini, S C Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 49 EP - 55 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 58 IS - 2 SN - 0026-5187, 0026-5187 KW - United States KW - mining KW - underground mining KW - roof control KW - stiffness KW - stability KW - mathematical models KW - rock mechanics KW - longwall mining KW - Western U.S. KW - mining geology KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51599458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Standing+support+alternatives+in+Western+United+States+longwalls&rft.au=Barczak%2C+T+M%3BTadolini%2C+S+C&rft.aulast=Barczak&rft.aufirst=T&rft.date=2006-02-01&rft.volume=58&rft.issue=2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ L2 - http://me.smenet.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 4 N1 - PubXState - CO N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - MIENAB N1 - SubjectsTermNotLitGenreText - design; longwall mining; mathematical models; mining; mining geology; rock mechanics; roof control; stability; stiffness; underground mining; United States; Western U.S. ER - TY - JOUR T1 - Comparative study of apparent stress at three underground mines AN - 51112766; 2006-089880 JF - Seismological Research Letters AU - Grant, E B AU - Chapman, M C AU - Iannacchione, A T AU - Anonymous Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 98 PB - Seismological Society of America, El Cerrito, CA VL - 77 IS - 1 SN - 0895-0695, 0895-0695 KW - United States KW - mining KW - mines KW - Willow Creek Mine KW - Australasia KW - underground mining KW - Newcastle Australia KW - stress KW - New South Wales Australia KW - seismicity KW - sampling KW - mining geology KW - Australia KW - Utah KW - Pennsylvania KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51112766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seismological+Research+Letters&rft.atitle=Comparative+study+of+apparent+stress+at+three+underground+mines&rft.au=Grant%2C+E+B%3BChapman%2C+M+C%3BIannacchione%2C+A+T%3BAnonymous&rft.aulast=Grant&rft.aufirst=E&rft.date=2006-02-01&rft.volume=77&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Seismological+Research+Letters&rft.issn=08950695&rft_id=info:doi/ L2 - http://srl.geoscienceworld.org/ LA - English DB - GeoRef N1 - Conference title - Seismological Society of America Eastern Section, 77th annual meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - CA N1 - Last updated - 2016-09-16 N1 - CODEN - EAQNAT N1 - SubjectsTermNotLitGenreText - Australasia; Australia; mines; mining; mining geology; New South Wales Australia; Newcastle Australia; Pennsylvania; sampling; seismicity; stress; underground mining; United States; Utah; Willow Creek Mine ER - TY - JOUR T1 - Tired titanium: a fatigue-based approach to aircraft inventory management and acquisition planning AN - 37766056; 3289296 AB - Airframe fatigue has emerged as a primary determinant of tactical aircraft service life. To investigate the impact of various operational scenarios on airframe fatigue and aircraft stocks, we develop an econometric model of fatigue and arrest landing accumulation for US Naval aircraft. Model forecasts suggest that fatigue-related attrition threatens to reduce inventories below the level needed to meet operational commitments before planned replacements are available. Changes to training regimes could mitigate the shortfall, but it is likely that acquisition schedules will have to be accelerated, or current service life extension programs expanded to maintain inventories in the future. Reprinted by permission of Harwood Academic Publishers, Taylor and Francis Ltd JF - Defence and peace economics AU - Meyerhoefer, Chad D AU - Trost, Robert P AD - Agency for Healthcare Research and Quality ; George Washington University Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1 EP - 22 VL - 17 IS - 1 SN - 1024-2694, 1024-2694 KW - Economics KW - Air force KW - Inventories KW - Stock management KW - Tactics KW - Planning methods KW - Econometric models KW - Conflict KW - Military expenditure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37766056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Defence+and+peace+economics&rft.atitle=Tired+titanium%3A+a+fatigue-based+approach+to+aircraft+inventory+management+and+acquisition+planning&rft.au=Meyerhoefer%2C+Chad+D%3BTrost%2C+Robert+P&rft.aulast=Meyerhoefer&rft.aufirst=Chad&rft.date=2006-02-01&rft.volume=17&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Defence+and+peace+economics&rft.issn=10242694&rft_id=info:doi/10.1080%2F10242690500369298 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8063 4618; 6846 1394 4937 7625; 12275 7625; 9560; 887 1262 8050; 12483; 3864 8163; 2698 DO - http://dx.doi.org/10.1080/10242690500369298 ER - TY - JOUR T1 - Cross-national variation of gender differences in adolescent subjective health in Europe and North America AN - 37696152; 3250939 JF - Social science and medicine AU - Torsheim, Torbjørn AU - Ravens-Sieberer, Ulrike AU - Hetland, Jorn AU - Välimaa, Raili AU - Danielson, Mia AU - Overpeck, Mary AD - University of Bergen ; Robert Koch Institute ; University of Jyväskylä ; National Institute of Public Health ; Health Resources and Services Administration Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 815 EP - 827 VL - 62 IS - 4 SN - 0277-9536, 0277-9536 KW - Sociology KW - Anthropology KW - North America KW - Sex inequality KW - Europe KW - Empowerment KW - Gender differentiation KW - Health inequality KW - Adolescents KW - Youth KW - Cross-national analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37696152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Cross-national+variation+of+gender+differences+in+adolescent+subjective+health+in+Europe+and+North+America&rft.au=Torsheim%2C+Torbj%C3%B8rn%3BRavens-Sieberer%2C+Ulrike%3BHetland%2C+Jorn%3BV%C3%A4limaa%2C+Raili%3BDanielson%2C+Mia%3BOverpeck%2C+Mary&rft.aulast=Torsheim&rft.aufirst=Torbj%C3%B8rn&rft.date=2006-02-01&rft.volume=62&rft.issue=4&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.06.047 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13779 652 5676 646 6091; 593; 5423 3549 2688 2449 10404; 5783 5772 6489; 3060 971; 11551; 4234 9754 9965; 129; 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2005.06.047 ER - TY - JOUR T1 - Invited commentary: rapid benefit-risk assessments: no escape from expert judgments in risk management AN - 36534959; 3345137 AB - The 'human health impacts assessment' described by Cox and Popken (this issue) is intended to be a benefit-risk tool that avoids pitfalls of using expert judgements for policy analysis or during strict application of the precautionary principle in risk management. The proposed benefit-risk calculation uses numerous assumptions and suppositions to calculate a ratio of quality-adjusted life years (QALYs) lost for the number of human illness days prevented by the use of a food-animal antimicrobial drug, to the number of human illness days caused by the use of the antimicrobial drug. Assumptions about data-e.g., expert judgments on the representativeness of parameter estimates-are commonly used in risk assessment and risk management, including Cox and Popken's method. Cox and Popken apply the technique to specific examples of enrofloxacin and macrolides antimicrobial drugs, sometimes used in broiler chickens for human food. Although enthusiastically portrayed as a straightforward calculation of QALYs lost for two decision alternatives, Cox and Popken were silent on the pivotal expert judgment subsumed in their method: quality weights for illnesses caused by antimicrobial-resistant and antimicrobial-sensitive microbes are tacitly assumed to be equal. Yet, the costs in terms of prolonged illness, additional medications, repeat medical visits, and dread of more serious sequelae are expected to differ substantially for antimicrobial-resistant versus antimicrobial-sensitive illnesses. Despite their enthusiasm to the contrary, the 'human health impacts assessment' by Cox and Popken is not immune from expert judgments in risk management. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Claycamp, H Gregg AD - Center for Veterinary Medicine Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 147 EP - 156 VL - 26 IS - 1 SN - 0272-4332, 0272-4332 KW - Economics KW - Sociology KW - Antibiotics KW - Evaluation KW - Risk management KW - Policy analysis KW - Illness KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36534959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Invited+commentary%3A+rapid+benefit-risk+assessments%3A+no+escape+from+expert+judgments+in+risk+management&rft.au=Claycamp%2C+H+Gregg&rft.aulast=Claycamp&rft.aufirst=H&rft.date=2006-02-01&rft.volume=26&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2006.00724.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11038 7625; 4551; 9617 971; 6220; 10449 5772 DO - http://dx.doi.org/10.1111/j.1539-6924.2006.00724.x ER - TY - JOUR T1 - Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: The Honolulu-Asia Aging Study AN - 20848639; 6644640 AB - The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1 alpha , IL-1 beta and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n = 931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1 beta (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1 beta (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1 beta (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia. JF - Neurobiology of Aging AU - Yucesoy, Berran AU - Peila, Rita AU - White, Lon R AU - Wu, Kim Ming AU - Johnson, Victor J AU - Kashon, Michael L AU - Luster, Michael I AU - Launer, Lenore J AD - Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, byucesoy@cdc.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 211 EP - 217 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 27 IS - 2 SN - 0197-4580, 0197-4580 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; CSA Neurosciences Abstracts KW - Interleukin-1 cytokine family KW - Polymorphisms KW - Alzheimer disease KW - Vascular dementia KW - Neurodegenerative diseases KW - Coding KW - Gene polymorphism KW - Aging KW - Alzheimer's disease KW - Interleukin 1 KW - Gene families KW - Interleukin 1 receptor antagonist KW - vascular dementia KW - Inflammation KW - Nervous system KW - Risk factors KW - Dementia disorders KW - Interleukin 1 receptors KW - N3 11126:Alzheimer's disease and other dementias KW - G 07880:Human Genetics KW - A 01490:Miscellaneous KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+Aging&rft.atitle=Association+of+interleukin-1+gene+polymorphisms+with+dementia+in+a+community-based+sample%3A+The+Honolulu-Asia+Aging+Study&rft.au=Yucesoy%2C+Berran%3BPeila%2C+Rita%3BWhite%2C+Lon+R%3BWu%2C+Kim+Ming%3BJohnson%2C+Victor+J%3BKashon%2C+Michael+L%3BLuster%2C+Michael+I%3BLauner%2C+Lenore+J&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2006-02-01&rft.volume=27&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+Aging&rft.issn=01974580&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2005.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Coding; Gene polymorphism; Interleukin 1; Alzheimer's disease; Aging; Gene families; vascular dementia; Interleukin 1 receptor antagonist; Inflammation; Neurodegenerative diseases; Nervous system; Risk factors; Dementia disorders; Interleukin 1 receptors DO - http://dx.doi.org/10.1016/j.neurobiolaging.2005.01.013 ER - TY - JOUR T1 - Bacterial Meningitis Among Children With Cochlear Implants Beyond 24 Months After Implantation AN - 20719203; 6662915 AB - BACKGROUND: More than 11000 children in the United States with severe-to-profound hearing loss have cochlear implants. A 2002 investigation involving pediatric cochlear implant recipients identified meningitis episodes from January 1, 1997, through September 15, 2002. The incidence of pneumococcal meningitis in the cohort was 138.2 cases per 100000 person-years, >30 times higher than that for children in the general US population. Children with implants with positioners were at higher risk than children with other implant models. This higher risk of bacterial meningitis continued for up to 24 months after implantation. OBJECTIVE: To evaluate additional reported cases to determine whether the increased rate of bacterial meningitis among children with cochlear implants extended beyond 24 months after implantation. METHODS: Our study population consisted of the cohort of children identified through the 2002 investigation; it included 4265 children who received cochlear implants in the United States between January 1, 1997, and August 6, 2002, and who were 24 months after implantation. When cases identified in the 2002 and 2004 investigations were combined, the incidence rate of greater than or equal to 24-months postimplantation bacterial meningitis among children with positioners was 450 cases per 100000 person-years, compared with no cases among children without positioners. CONCLUSIONS: Our updated findings support continued monitoring and prompt treatment of bacterial infections by health care providers and parents of children with cochlear implants. This vigilance remains important beyond 2 years after implantation, particularly among children with positioners. The vaccination recommendations for all children with implants, with and without positioners, and all potential recipients of implants continue to apply. JF - Pediatrics AU - Biernath, Krista R AU - Reefhuis, Jennita AU - Whitney, Cynthia G AU - Mann, Eric A AU - Costa, Pamela AU - Eichwald, John AU - Boyle, Coleen AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Food and Drug Administration, Rockville, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 284 EP - 289 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 2 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Cochlea KW - Bacteria KW - Age KW - Pediatrics KW - Population studies KW - Hearing loss KW - Children KW - Infection KW - Vaccination KW - Meningitis KW - Models KW - Streptococcus pneumoniae KW - Risk factors KW - Vigilance KW - J 02400:Human Diseases KW - W 30965:Miscellaneous, Reviews KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20719203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Bacterial+Meningitis+Among+Children+With+Cochlear+Implants+Beyond+24+Months+After+Implantation&rft.au=Biernath%2C+Krista+R%3BReefhuis%2C+Jennita%3BWhitney%2C+Cynthia+G%3BMann%2C+Eric+A%3BCosta%2C+Pamela%3BEichwald%2C+John%3BBoyle%2C+Coleen&rft.aulast=Biernath&rft.aufirst=Krista&rft.date=2006-02-01&rft.volume=117&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cochlea; Age; Pediatrics; Risk factors; Population studies; Vigilance; Hearing loss; Infection; Children; Vaccination; Models; Meningitis; Bacteria; Streptococcus pneumoniae ER - TY - JOUR T1 - Stable Growth of Wild-Type Hepatitis A Virus in Cell Culture AN - 20243620; 6662390 AB - Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable of supporting the efficient growth of wt HAV, we transfected different cell lines with in vitro RNA transcripts of wt HAV containing the blasticidin resistance gene. Blasticidin-resistant colonies grew only in transfected Huh7 cells and produced infectious virus. HAV was genetically stable in Huh7 cells for at least nine serial passages and did not accumulate attenuating or cell culture-adapting mutations. Treatment with alpha interferon A/D cured the blasticidin-resistant Huh7 cells of the HAV infection. The cured cells, termed Huh7-A-I cells, did not contain virus or HAV antigens and were sensitive to blasticidin. Huh7-A-I cells were more permissive than parental cells for wt HAV infection, including a natural isolate from a human stool sample, and produced 10-fold-more infectious particles. This is the first report of a cell line that allows the genetically stable growth of human wt HAV. The viral vectors and cells described here should allow better insight into the pathogenesis of HAV and the development of attenuated vaccines. The cell lines susceptible to wt HAV growth may also be used to detect and isolate infectious virus from patient and environmental samples. JF - Journal of Virology AU - Konduru, Krishnamurthy AU - Kaplan, Gerardo G AD - Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1352 EP - 1360 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 3 SN - 0022-538X, 0022-538X KW - blasticidin KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Hepatitis A virus KW - Attenuation KW - Cell culture KW - Infection KW - Hepatitis KW - Colonies KW - RNA KW - Transfection KW - alpha -Interferon KW - Vaccines KW - Feces KW - Mutation KW - W 30905:Medical Applications KW - V 22023:Virus behavior in cell culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Stable+Growth+of+Wild-Type+Hepatitis+A+Virus+in+Cell+Culture&rft.au=Konduru%2C+Krishnamurthy%3BKaplan%2C+Gerardo+G&rft.aulast=Konduru&rft.aufirst=Krishnamurthy&rft.date=2006-02-01&rft.volume=80&rft.issue=3&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hepatitis; Colonies; RNA; Transfection; alpha -Interferon; Attenuation; Cell culture; Vaccines; Infection; Feces; Mutation; Hepatitis A virus ER - TY - JOUR T1 - Detection of Type A, B, E, and F Clostridium botulinum Neurotoxins in Foods by Using an Amplified Enzyme-Linked Immunosorbent Assay with Digoxigenin-Labeled Antibodies AN - 19942035; 6716119 AB - An amplified enzyme-linked immunosorbent assay (ELISA) for the detection of Clostridium botulinum complex neurotoxins was evaluated for its ability to detect these toxins in food. The assay was found to be suitable for detecting type A, B, E, and F botulinum neurotoxins in a variety of food matrices representing liquids, solid, and semisolid food. Specific foods included broccoli, orange juice, bottled water, cola soft drinks, vanilla extract, oregano, potato salad, apple juice, meat products, and dairy foods. The detection sensitivity of the test for these botulinum complex serotypes was found to be 60 pg/ml (1.9 50% lethal dose [LD sub(50)]) for botulinum neurotoxin type A (BoNT/A), 176 pg/ml (1.58 LD sub(50)) for BoNT/B, 163 pg/ml for BoNT/E (4.5 LD sub(50)), and 117 pg/ml for BoNT/F (less than 1 LD sub(50)) in casein buffer. The test could also readily detect 2 ng/ml of neurotoxins type A, B, E, and F in a variety of food samples. For specificity studies, the assay was also used to test a large panel of type A C. botulinum, a smaller panel of proteolytic and nonproteolytic type B, E, and F neurotoxin-producing Clostridia, and nontoxigenic organisms using an overnight incubation of toxin production medium. The assay appears to be an effective tool for large-scale screening of the food supply in the event of a botulinum neurotoxin contamination event. JF - Applied and Environmental Microbiology AU - Sharma, Shashi K AU - Ferreira, JosephL AU - Eblen, Brian S AU - Whiting, Richard C AD - U.S. Food and Drug Administration, Center for Food Safety Applied Nutrition, College Park, Maryland 20740. Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1231 EP - 1238 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 2 SN - 0099-2240, 0099-2240 KW - Potato KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Citrus KW - Proteolysis KW - Meat products KW - Serotypes KW - Food KW - Juices KW - Dairy products KW - Origanum KW - Clostridium botulinum KW - Vanilla KW - Solanum tuberosum KW - Malus KW - Botulinum toxin KW - Enzyme-linked immunosorbent assay KW - Beverages KW - Food contamination KW - Brassica KW - Casein KW - Fruit juices KW - Antibodies KW - Dairies KW - Neurotoxins KW - Immunoassays KW - vanilla KW - Lethal dose KW - A 01017:Human foods KW - A 01116:Bacteria KW - J 02420:Plant Diseases KW - X 24320:Food Additives & Contaminants KW - W 30965:Miscellaneous, Reviews KW - H 4000:Food and Drugs KW - A 01023:Others KW - W2 32240:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19942035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Detection+of+Type+A%2C+B%2C+E%2C+and+F+Clostridium+botulinum+Neurotoxins+in+Foods+by+Using+an+Amplified+Enzyme-Linked+Immunosorbent+Assay+with+Digoxigenin-Labeled+Antibodies&rft.au=Sharma%2C+Shashi+K%3BFerreira%2C+JosephL%3BEblen%2C+Brian+S%3BWhiting%2C+Richard+C&rft.aulast=Sharma&rft.aufirst=Shashi&rft.date=2006-02-01&rft.volume=72&rft.issue=2&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Meat products; Proteolysis; Enzyme-linked immunosorbent assay; Serotypes; Beverages; Food; Dairy products; Juices; Food contamination; Casein; Fruit juices; Dairies; Antibodies; Botulinum toxin; Neurotoxins; vanilla; Lethal dose; Immunoassays; Citrus; Solanum tuberosum; Malus; Origanum; Clostridium botulinum; Brassica; Vanilla ER - TY - JOUR T1 - Use of Opsonophagocytosis for Serological Evaluation of Pneumococcal Vaccines AN - 19941930; 6718572 AB - Since 2000, when a pneumococcal conjugate vaccine (Prevnar) was introduced, pneumococcal infections in the United States among children have been dramatically reduced. The conjugate vaccine elicits antibodies to pneumococcal capsular polysaccharide, and these antibodies protect the host by opsonizing pneumococci and thus facilitating phagocytosis. The ability of a serum sample to opsonize bacteria can be measured by various in vitro opsonophagocytosis assays (OPAs), and OPAs have been shown to be the best functional correlate of protection in various studies. A minimum opsonic titer of 1:8 confers protection in a mouse model, is correlated with protection in infants vaccinated with pneumococcal conjugate vaccine, and was shown in infants to correspond to an immunoglobulin G (IgG) antibody concentration of 0.2 to 0.35 µg/ml (5). A Finnish study with an 11-valent pneumococcal conjugate vaccine conducted in the Philippines showed a good correlation between an opsonophagocytic killing assay and the IgG antibodies as measured by enzyme-linked immunosorbent assay (ELISA) (12), although the correlation may be limited in some populations, as described later in this review. JF - Clinical and Vaccine Immunology AU - Romero-Steiner, Sandra AU - Frasch, Carl E AU - Carlone, George AU - Fleck, Roland A AU - Goldblatt, David AU - Nahm, Moon H AD - Centers for Disease Control and Prevention, Atlanta, Georgia 30333. Food and Drug Administration, Bethesda, Maryland 20892. National Institute for Biological Standards and Control, South Mimms, England. Institute of Child Health, University College London, London, England. and University of Alabama at Birmingham, Birmingham, Alabama 35249 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 165 EP - 169 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 2 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - opsonophagocytosis KW - Animal models KW - Polysaccharides KW - Infection KW - Children KW - Streptococcus pneumoniae KW - Reviews KW - Immunoglobulin G KW - Vaccines KW - Phagocytosis KW - Capsular polysaccharides KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19941930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Use+of+Opsonophagocytosis+for+Serological+Evaluation+of+Pneumococcal+Vaccines&rft.au=Romero-Steiner%2C+Sandra%3BFrasch%2C+Carl+E%3BCarlone%2C+George%3BFleck%2C+Roland+A%3BGoldblatt%2C+David%3BNahm%2C+Moon+H&rft.aulast=Romero-Steiner&rft.aufirst=Sandra&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Reviews; Animal models; opsonophagocytosis; Immunoglobulin G; Vaccines; Children; Infection; Polysaccharides; Phagocytosis; Capsular polysaccharides; Infants; Streptococcus pneumoniae ER - TY - JOUR T1 - Factors affecting the ultraviolet inactivation of Escherichia coli K12 in apple juice and a model system AN - 19772283; 6764615 AB - Ultraviolet (UV) light has been used successfully for years to sterilize water and was recently approved as an acceptable irradiation treatment for the processing of juice. Although there is considerable information on the efficacy of UV processing in the treatment of water, limited data are available on its efficacy in fluid food systems. The objectives of this work were to determine the effects of apple-juice properties on the UV inactivation of Escherichia coli K12 and the interdependence of intensity and time on the efficacy of UV light. Results showed that absorbance (A) and suspended solids (SS) affected UV inactivation, while pH and dissolved solids did not. Concerning the interdependence of intensity and time, intensity levels can only be changed without sacrificing effectiveness at a limited range of intensity and dose levels. This means that the range of the intensity level of the actual UV reactor must be considered in process-parameter determination. JF - Journal of Food Process Engineering AU - Murakami, Edgar G AU - Jackson, Lauren AU - Madsen, Kevin AU - Schickedanz, Brian AD - Food and Drug Administration National Center for Food Safety and Technology 6502 S. Archer Ave. Summit-Argo, IL 60501, Edgar.Murakami@fda.hhs.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 53 EP - 71 PB - Food & Nutrition Press Inc., 6527 Main St. P.O. Box 374 Trumbull CT 06611 USA, [mailto:foodpress@worldnetatt.net], [URL:http://www.foodscipress.com/] VL - 29 IS - 1 SN - 0145-8876, 0145-8876 KW - fruit juices KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Food processing KW - Data processing KW - Food KW - Juices KW - Food contamination KW - Fruit juices KW - U.V. radiation KW - Radiation KW - Process engineering KW - Ultraviolet radiation KW - Escherichia coli KW - Malus KW - Absorbance KW - pH effects KW - pH KW - Food irradiation KW - A 01019:Sterilization, preservation & packaging KW - J 02420:Plant Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Process+Engineering&rft.atitle=Factors+affecting+the+ultraviolet+inactivation+of+Escherichia+coli+K12+in+apple+juice+and+a+model+system&rft.au=Murakami%2C+Edgar+G%3BJackson%2C+Lauren%3BMadsen%2C+Kevin%3BSchickedanz%2C+Brian&rft.aulast=Murakami&rft.aufirst=Edgar&rft.date=2006-02-01&rft.volume=29&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Process+Engineering&rft.issn=01458876&rft_id=info:doi/10.1111%2Fj.1745-4530.2006.00049.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - SuppNotes - Figures, 3; tables, 8; formulas, 6; references, 24. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Fruit juices; Data processing; U.V. radiation; Radiation; Food; Process engineering; Juices; Absorbance; pH effects; Ultraviolet radiation; Food contamination; pH; Food irradiation; Escherichia coli; Malus DO - http://dx.doi.org/10.1111/j.1745-4530.2006.00049.x ER - TY - JOUR T1 - Detectability Decreases With Off-Normal Viewing in Medical Liquid Crystal Displays AN - 19483626; 7185037 AB - To quantify the reduction in detection performance of subtle signals at off-normal viewing directions in medical active-matrix liquid crystal displays (AMLCDs). Fifty synthetic image pairs per viewing condition (a total of 350) were used in a two-alternative forced-choice experiment in which 11 trained observers viewed images at 0, 30, and 45 degrees from the display normal, along the diagonal axis of a 5 million pixel in-plane switching monochrome AMLCD. The images were generated using white-noise backgrounds. A Gaussian signal was added to the signal-present set with three different signal amplitudes (4, 8, and 12 gray levels in a 10-bit scale). The average percent correct achieved for a signal of 4 gray levels was 79.6 (95% confidence intervals based on reader and case variability: 71.686.9), 63.4 (CI 56.071.3), and 55.3 (CI 48.462.0), for 0, 30 and 45 degrees from the display normal, respectively. When the signal amplitude was increased by a factor of two, the performance was 76.9 and 57.0 for 30 and 45 degrees, respectively, and 95.3 and 85.3 when the amplitude was increased by a factor of three. The observers took on average about twice as long and as much as seven times as long to reach decisions in off-normal viewing. Off-normal viewing of diagnostic images in AMLCDs significantly reduces the detection of low-contrast abnormalities. Increased off-normal signal amplitudes were required to regain the detection performance measured for normal viewing. We observed this decrease in detection performance for off-normal viewing even when measured decision times were about twice as long as for normal viewing. JF - Academic Radiology AU - Badano, A AU - Gallas, B D AD - NIBIB/CDRH Laboratory for the Assessment of Medical Imaging, Center for Devices and Radiological Health, Food and Drug Administration, 12720 Twinbrook Parkway, HFZ-142, Rockville, MD 20857 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 210 EP - 218 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 2 SN - 1076-6332, 1076-6332 KW - Biotechnology and Bioengineering Abstracts KW - Gaussian signals KW - Crystals KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19483626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+Radiology&rft.atitle=Detectability+Decreases+With+Off-Normal+Viewing+in+Medical+Liquid+Crystal+Displays&rft.au=Badano%2C+A%3BGallas%2C+B+D&rft.aulast=Badano&rft.aufirst=A&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Academic+Radiology&rft.issn=10766332&rft_id=info:doi/10.1016%2Fj.acra.2005.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Crystals; Gaussian signals DO - http://dx.doi.org/10.1016/j.acra.2005.08.015 ER - TY - JOUR T1 - Nicotine as a typical drug of abuse in experimental animals and humans AN - 19284520; 7025264 AB - Rationale and background: Tobacco use through cigarette smoking is the leading preventable cause of death in the developed world. Nicotine, a psychoactive component of tobacco, appears to play a major role in tobacco dependence, but reinforcing effects of nicotine often are difficult to demonstrate directly in controlled laboratory studies with animal or human subjects. Objective: To review the major findings obtained with various procedures developed to study dependence-related behavioral effects of nicotine in experimental animals and humans, i.e., drug self-administration, conditioned place preference, subjective reports of nicotine effects and nicotine discrimination, withdrawal signs, and ratings of drug withdrawal. Results: Nicotine can function as an effective reinforcer of drug-seeking and drug-taking behavior both in experimental animals and humans under appropriate conditions. Interruption of chronic nicotine exposure produces withdrawal symptoms that may contribute to relapse. Difficulties encountered in demonstrating reinforcing effects of nicotine under some conditions, relative to other drugs of abuse, may be due to weaker primary reinforcing effects of nicotine or to a more critical contribution of environmental stimuli to the maintenance of drug-seeking and drug-taking behavior with nicotine than with other drugs of abuse. Further experiments are also needed to delineate the role other chemical substances inhaled along with nicotine in tobacco smoke play in sustaining smoking behavior. Conclusion: Nicotine acts as a typical drug of abuse in experimental animals and humans. JF - Psychopharmacology AU - Foll, Bernard AU - Goldberg, Steven R AD - Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA, blefoll@intra.nida.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 367 EP - 381 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 184 IS - 3-4 SN - 0033-3158, 0033-3158 KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Smoke KW - Place preferences KW - Nicotine KW - Withdrawal KW - Reviews KW - Cigarette smoking KW - Tobacco KW - Reinforcement KW - Environmental effects KW - Drug abuse KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Nicotine+as+a+typical+drug+of+abuse+in+experimental+animals+and+humans&rft.au=Foll%2C+Bernard%3BGoldberg%2C+Steven+R&rft.aulast=Foll&rft.aufirst=Bernard&rft.date=2006-02-01&rft.volume=184&rft.issue=3-4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-005-0155-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoke; Place preferences; Nicotine; Reviews; Withdrawal; Cigarette smoking; Environmental effects; Reinforcement; Tobacco; Drug abuse; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-005-0155-8 ER - TY - JOUR T1 - Differential strength of association of child injury prevention attitudes and beliefs on practices: a case for audience segmentation AN - 17481742; 6666257 AB - OBJECTIVE: Many injuries to children cannot be prevented without some degree of active behavior on the part of parents. A better understanding of social and cognitive determinants of parents' injury prevention behavior and the identification of potential subgroups for targeted message delivery could advance the effectiveness of educational and behavioral interventions. This study assessed the degree to which parents' injury prevention behavior is associated with theoretical determinants and examined whether this relation differs by age or birth order of child. DESIGN: Cross sectional observational study. SETTING: Three Midwestern pediatric clinics. SUBJECTS: 594 parents of children ages 0-4 attending routine well child visits. MEASURES: Injury prevention attitudes, beliefs, and practices. RESULTS: Overall, only modest relations were observed between injury beliefs and attitudes and injury prevention behaviors. However, these relations differed substantially by child age and birth order, with stronger associations observed for parents of older first born children. Outcome expectations and social norms were more strongly related to injury prevention behavior among parents of preschool children than among parents of infants and toddlers, while attitudes were more predictive for parents of first born children than parents of later born children. CONCLUSIONS: These findings highlight the complexity of relations between theorized determinants and behavior, and suggest the potential utility of using audience segmentation strategies in behavioral interventions addressing injury prevention. JF - Injury Prevention AU - Vladutiu, C J AU - Nansel, T R AU - Weaver, N L AU - Jacobsen, H A AU - Kreuter, M W AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services. Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services. Health Communication Research Laboratory Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 35 EP - 40 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 12 IS - 1 SN - 1353-8047, 1353-8047 KW - parental supervision KW - Physical Education Index; Health & Safety Science Abstracts KW - Age KW - Injuries KW - Pediatrics KW - Preventive health KW - Strategy KW - Preschool children KW - Intervention KW - Health (behavior) KW - Children KW - Birth order KW - Prevention KW - Attitudes KW - Behavior KW - Standards KW - Human factors KW - Parents KW - Infants KW - H 11000:Diseases/Injuries/Trauma KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17481742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Differential+strength+of+association+of+child+injury+prevention+attitudes+and+beliefs+on+practices%3A+a+case+for+audience+segmentation&rft.au=Vladutiu%2C+C+J%3BNansel%2C+T+R%3BWeaver%2C+N+L%3BJacobsen%2C+H+A%3BKreuter%2C+M+W&rft.aulast=Vladutiu&rft.aufirst=C&rft.date=2006-02-01&rft.volume=12&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Injuries; Preventive health; Pediatrics; Strategy; Health (behavior); Intervention; Preschool children; Children; Birth order; Attitudes; Standards; Parents; Prevention; Behavior; Human factors; Infants ER - TY - JOUR T1 - Mammalian Steroid Hormones Are Substrates for the Major RND- and MFS-Type Tripartite Multidrug Efflux Pumps of Escherichia coli AN - 17465761; 6660965 AB - A steroid-hormone-dependent growth suppression was observed in Escherichia coli efflux-deficient backgrounds containing mutations in the major RND- and MFS-type tripartite multidrug efflux systems, AcrAB-TolC and EmrAB-TolC, respectively. In addition to their previously known natural steroid spectrum, which includes bile acids, both systems were shown to transport the hormones estradiol and progesterone, whereas hydrocortisone served as a substrate of only AcrAB-TolC. Furthermore, at least two other RND-type pumps, YhiV and AcrD, were capable of transporting such hormones when overexpressed on plasmid vectors (with some demonstrable specificity observed with AcrD). When this activity was examined in a wild-type background, cell-associated estradiol levels remained largely unaffected by competition with exogenous bile acids and hydrocortisone, in contrast to progesterone, which produced a significant modulation in estradiol uptake. JF - Journal of Bacteriology AU - Elkins, Christopher A AU - Mullis, Lisa B AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1191 EP - 1195 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 3 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Hydrocortisone KW - Progesterone KW - Bile acids KW - Escherichia coli KW - Steroid hormones KW - Plasmids KW - Mutation KW - Estradiol KW - J 02727:Amino acids, peptides and proteins KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17465761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mammalian+Steroid+Hormones+Are+Substrates+for+the+Major+RND-+and+MFS-Type+Tripartite+Multidrug+Efflux+Pumps+of+Escherichia+coli&rft.au=Elkins%2C+Christopher+A%3BMullis%2C+Lisa+B&rft.aulast=Elkins&rft.aufirst=Christopher&rft.date=2006-02-01&rft.volume=188&rft.issue=3&rft.spage=1191&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hydrocortisone; Progesterone; Bile acids; Steroid hormones; Plasmids; Mutation; Estradiol; Escherichia coli ER - TY - JOUR T1 - Beryllium exposure: dermal and immunological considerations AN - 17230831; 6953218 AB - Objective: People exposed to beryllium compounds are at increased risk of developing beryllium sensitization and chronic beryllium disease (CBD). The purpose of this short communication is to present information regarding the potential importance of skin exposure to beryllium, an exposure and alternate immune response pathway to the respiratory tract, which has been largely overlooked in epidemiologic and exposure assessment studies. Methods: We reviewed the published literature, including epidemiologic, immunologic, genetic, and laboratory-based studies of in vivo and in vitro models, to assess the state of knowledge concerning skin exposure to beryllium. Results: Reduction in inhalation exposure to beryllium has not resulted in a concomitant reduction in the occurrence of beryllium sensitization or CBD, suggesting that continued prevalence may be due, in part, to unchecked skin exposure to beryllium-containing particles. Conclusions: Recent developments in our understanding of the multiple exposure pathways that may lead to beryllium sensitization and CBD suggest that a prudent approach to worker protection is to assess and minimize both skin and inhalation exposures to beryllium. JF - International Archives of Occupational and Environmental Health AU - Day, Gregory A AU - Stefaniak, Aleksandr B AU - Weston, Ainsley AU - Tinkle, Sally S AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2703, Morgantown, WV, 26505-2888, USA, gdd2@cdc.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 161 EP - 164 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 79 IS - 2 SN - 0340-0131, 0340-0131 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Risk assessment KW - Berylliosis KW - Skin KW - Immunology KW - Models KW - occupational diseases KW - Reviews KW - Risk factors KW - Beryllium KW - Immune response KW - Occupational exposure KW - Respiratory tract KW - X 24164:Pathology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17230831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Beryllium+exposure%3A+dermal+and+immunological+considerations&rft.au=Day%2C+Gregory+A%3BStefaniak%2C+Aleksandr+B%3BWeston%2C+Ainsley%3BTinkle%2C+Sally+S&rft.aulast=Day&rft.aufirst=Gregory&rft.date=2006-02-01&rft.volume=79&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-005-0024-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Berylliosis; Risk assessment; Inhalation; Skin; Risk factors; Reviews; Beryllium; Immune response; Occupational exposure; Models; Respiratory tract; occupational diseases; Immunology DO - http://dx.doi.org/10.1007/s00420-005-0024-0 ER - TY - JOUR T1 - A Search for Thresholds and Other Nonlinearities in the Relationship Between Hexavalent Chromium and Lung Cancer AN - 17151952; 6766658 AB - The exposure-response relationship for airborne hexavalent chromium exposure and lung cancer mortality is well described by a linear relative rate model. However, categorical analyses have been interpreted to suggest the presence of a threshold. This study investigates nonlinear features of the exposure response in a cohort of 2,357 chemical workers with 122 lung cancer deaths. In Poisson regression, a simple model representing a two-step carcinogenesis process was evaluated. In a one-stage context, fractional polynomials were investigated. Cumulative exposure dose metrics were examined corresponding to cumulative exposure thresholds, exposure intensity (concentration) thresholds, dose-rate effects, and declining burden of accumulated effect on future risk. A simple two-stage model of carcinogenesis provided no improvement in fit. The best-fitting one-stage models used simple cumulative exposure with no threshold for exposure intensity and had sufficient power to rule out thresholds as large as 30 mu g-m super(3) CrO sub(3) (16 mu g-m super(3) as Cr super(+6)) (one-sided 95% confidence limit, likelihood ratio test). Slightly better-fitting models were observed with cumulative exposure thresholds of 0.03 and 0.5 mg-yr-m super(3) (as CrO sub(3)) with and without an exposure-race interaction term, respectively. With the best model, cumulative exposure thresholds as large as 0.4 mg-yr-m super(3) CrO sub(3) were excluded (two-sided upper 95% confidence limit, likelihood ratio test). A small departure from dose-rate linearity was observed, corresponding to (intensity) super(0.8) but was not statistically significant. Models in which risk-inducing damage burdens declined over time, based on half-lives ranging from 0.1 to 40 years, fit less well than assuming a constant burden. A half-life of 8 years or less was excluded (one-sided 95% confidence limit). Examination of nonlinear features of the hexavalent chromium-lung cancer exposure response in a population used in a recent risk assessment supports using the traditional (lagged) cumulative exposure paradigm: no intensity (concentration) threshold, linearity in intensity, and constant increment in risk following exposure. JF - Risk Analysis AU - Park, Robert M AU - Stayner, Leslie T AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA, rhp9@cdc.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 79 EP - 88 PB - Blackwell Science Ltd., Osney Mead Oxford OX2 0EL UK, [mailto:journals.cs@blacksci.co.uk], [URL:http://www.blacksci.co.uk] VL - 26 IS - 1 SN - 0272-4332, 0272-4332 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Burden KW - dose rate KW - nonlinear exposure response KW - threshold KW - two-stage KW - Inhalation KW - Risk assessment KW - Mortality KW - Mathematical models KW - Chromium KW - Statistical analysis KW - Carcinogenesis KW - Regression analysis KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - X 24164:Pathology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17151952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=A+Search+for+Thresholds+and+Other+Nonlinearities+in+the+Relationship+Between+Hexavalent+Chromium+and+Lung+Cancer&rft.au=Park%2C+Robert+M%3BStayner%2C+Leslie+T&rft.aulast=Park&rft.aufirst=Robert&rft.date=2006-02-01&rft.volume=26&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2006.00709.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - SuppNotes - Figures, 2; tables, 5; formulas, 14; references, 23. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Mathematical models; Chromium; Carcinogenesis; Regression analysis; Statistical analysis; Occupational exposure; Lung cancer; Inhalation DO - http://dx.doi.org/10.1111/j.1539-6924.2006.00709.x ER - TY - JOUR T1 - Molecular Cloning and Expression of Genes Encoding a Novel Dioxygenase Involved in Low- and High-Molecular-Weight Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1 AN - 17088853; 6716096 AB - Mycobacterium vanbaalenii PYR-1 is able to metabolize a wide range of low- and high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). A 20-kDa protein was upregulated in PAH-metabolizing M. vanbaalenii PYR-1 cells compared to control cultures. The differentially expressed protein was identified as a beta subunit of the terminal dioxygenase using mass spectrometry. PCR with degenerate primers designed based on de novo sequenced peptides and a series of plaque hybridizations were done to screen the M. vanbaalenii PYR-1 genomic library. The genes, designated nidA3B3, encoding the alpha and beta subunits of terminal dioxygenase, were subsequently cloned and sequenced. The deduced enzyme revealed close similarities to the corresponding PAH ring-hydroxylating dioxygenases from Mycobacterium and Rhodococcus spp. but had the highest similarity, 61.9%, to the alpha subunit from Nocardioides sp. strain KP7. The alpha subunit also showed 52% sequence homology with the previously reported NidA from M. vanbaalenii PYR-1. The genes nidA3B3 were subcloned into the expression vector pET-17b, and the enzyme activity in Escherichia coli cells was reconstituted through coexpression with the ferredoxin (PhdC) and ferredoxin reductase (PhdD) genes of the phenanthrene dioxygenase from Nocardioides sp. strain KP7. The recombinant PAH dioxygenase appeared to favor the HMW PAH substrates fluoranthene, pyrene, and phenanthrene. Several other PAHs, including naphthalene, anthracene, and benz[a]anthracene, were also converted to their corresponding cis-dihydrodiols. The recombinant E. coli, however, did not show any dioxygenation activity for phthalate and biphenyl. The upregulation of nidA3B3 in M. vanbaalenii PYR-1 induced by PAHs was confirmed by reverse transcription-PCR analysis. JF - Applied and Environmental Microbiology AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Freeman, James P AU - Jones, Richard C AU - Adjei, Michael D AU - Jhoo, Jin-Woo AU - Edmondson, Ricky D AU - Cerniglia, Carl E AD - Division of Microbiology. Division of Biochemical Toxicology. Division of Systems Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, Arkansas 72079. Department of Food Science and Technology in Animal Resources, Kangwon National University, Chuncheon 200-701, Republic of Korea Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1045 EP - 1054 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 2 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology KW - Anthracene KW - Biodegradation KW - Mycobacterium KW - ferredoxin reductase KW - Cell culture KW - Pyrene KW - Mass spectroscopy KW - Nocardioides KW - Rhodococcus KW - Expression vectors KW - Escherichia coli KW - Polymerase chain reaction KW - Plaques KW - genomics KW - Dioxygenase KW - Fluoranthene KW - Mycobacterium vanbaalenii KW - Polycyclic aromatic hydrocarbons KW - Enzymes KW - Naphthalene KW - Ferredoxin KW - Phthalic acid KW - Biphenyl KW - Phenanthrene KW - Homology KW - Primers KW - J 02728:Enzymes KW - W2 32310:Enzymes and cofactors KW - W 30965:Miscellaneous, Reviews KW - G 07770:Bacteria KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17088853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Molecular+Cloning+and+Expression+of+Genes+Encoding+a+Novel+Dioxygenase+Involved+in+Low-+and+High-Molecular-Weight+Polycyclic+Aromatic+Hydrocarbon+Degradation+in+Mycobacterium+vanbaalenii+PYR-1&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BFreeman%2C+James+P%3BJones%2C+Richard+C%3BAdjei%2C+Michael+D%3BJhoo%2C+Jin-Woo%3BEdmondson%2C+Ricky+D%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2006-02-01&rft.volume=72&rft.issue=2&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Anthracene; Fluoranthene; Polycyclic aromatic hydrocarbons; Biodegradation; Naphthalene; ferredoxin reductase; Enzymes; Cell culture; Pyrene; Ferredoxin; Mass spectroscopy; Phthalic acid; Biphenyl; Expression vectors; Phenanthrene; Homology; Polymerase chain reaction; Plaques; Primers; genomics; Dioxygenase; Rhodococcus; Nocardioides; Mycobacterium vanbaalenii; Mycobacterium; Escherichia coli ER - TY - JOUR T1 - Evaluation of Carbon Monoxide Emissions from Engines on Recreational Boats Equipped with Prototype Catalysts AN - 17081520; 6708477 AB - During fall 2000, National Institute for Occupational Safety and Health (NIOSH) investigators became aware of a series of carbon monoxide (CO) poisonings that had occurred on and around houseboats on Lake Powell in Arizona. An epidemiologic investigation found that between 1990 and 2004, 111 fatal CO poisonings and 445 nonfatal poisonings that involved various types of boats occurred in the United States. Concurrent with the epidemiologic investigations, a series of industrial hygiene studies to characterize CO exposures associated with house and recreational boats was conducted. These studies demonstrated that hazardous CO concentrations were often present on and around houseboats and other recreational boats when they were stationary and their engines were running. JF - Journal of Occupational and Environmental Hygiene AU - Mazzuckelli, L F AU - Hall, R M AU - Earnest, S G AU - Carroll, J N AU - Spencer, A AD - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - D4 EP - D7 VL - 3 IS - 2 SN - 1545-9624, 1545-9624 KW - boats KW - Pollution Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Carbon monoxide KW - USA, Arizona, Powell L. KW - Recreation areas KW - Combustion products KW - Occupational safety KW - Poisoning KW - Public health KW - R2 23080:Industrial and labor KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17081520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+Carbon+Monoxide+Emissions+from+Engines+on+Recreational+Boats+Equipped+with+Prototype+Catalysts&rft.au=Mazzuckelli%2C+L+F%3BHall%2C+R+M%3BEarnest%2C+S+G%3BCarroll%2C+J+N%3BSpencer%2C+A&rft.aulast=Mazzuckelli&rft.aufirst=L&rft.date=2006-02-01&rft.volume=3&rft.issue=2&rft.spage=D4&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620500496699 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Carbon monoxide; Combustion products; Recreation areas; Occupational safety; Poisoning; Public health; USA, Arizona, Powell L. DO - http://dx.doi.org/10.1080/15459620500496699 ER - TY - JOUR T1 - DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane. AN - 70736891; 16412685 AB - 1-bromopropane (1-BP; n-propyl bromide) (CAS No. 106-94-5) is an alternative to ozone-depleting chlorofluorocarbons that has a variety of potential applications as a degreasing agent for metals and electronics, and as a solvent vehicle for spray adhesives. Its isomer, 2-brompropane (2-BP; isopropyl bromide) (CAS No. 75-26-3) impairs antioxidant cellular defenses, enhances lipid peroxidation, and causes DNA damage in vitro. The present study had two aims. The first was to assess DNA damage in human leukocytes exposed in vitro to 1- or 2-BP. DNA damage was also assessed in peripheral leukocytes from workers with occupational exposure to 1-BP. In the latter assessment, start-of- and end-of-work week blood and urine samples were collected from 41 and 22 workers at two facilities where 1-BP was used as a solvent for spray adhesives in foam cushion fabrication. Exposure to 1-BP was assessed from personal-breathing zone samples collected for 1-3 days up to 8h per day for calculation of 8h time weighted average (TWA) 1-BP concentrations. Bromide (Br) was measured in blood and urine as a biomarker of exposure. Overall, 1-BP TWA concentrations ranged from 0.2 to 271 parts per million (ppm) at facility A, and from 4 to 27 ppm at facility B. The highest exposures were to workers classified as sprayers. 1-BP TWA concentrations were statistically significantly correlated with blood and urine Br concentrations. The comet assay was used to estimate DNA damage. In vitro, 1- or 2-BP induced a statistically significant increase in DNA damage at 1mM. In 1-BP exposed workers, start-of- and end-of-workweek comet endpoints were stratified based on job classification. There were no significant differences in DNA damage in leukocytes between workers classified as sprayers (high 1-BP exposure) and those classified as non-sprayers (low 1-BP exposure). At the facility with the high exposures, comparison of end-of-week values with start-of-week values using paired analysis revealed non-sprayers had significantly increased comet tail moments, and sprayers had significantly increased comet tail moment dispersion coefficients. A multivariate analysis included combining the data sets from both facilities, log transformation of 1-BP exposure indices, and the use of multiple linear regression models for each combination of DNA damage and exposure indices including exposure quartiles. The covariates were gender, age, smoking status, facility, and glutathione S-transferase M1 and T1 (GSTM1, GSTT1) polymorphisms. In the regression models, start-of-week comet tail moment in leukocytes was significantly associated with serum Br quartiles. End-of-week comet tail moment was significantly associated with 1-BP TWA quartiles, and serum Br quartiles. Gender, facility, and GSTM1 had a significant effect in one or more models. Additional associations were not identified from assessment of dispersion coefficients. In vitro and in vivo results provide limited evidence that 1-BP exposure may pose a small risk for increasing DNA damage. JF - Mutation research AU - Toraason, Mark AU - Lynch, Dennis W AU - DeBord, D Gayle AU - Singh, Narendra AU - Krieg, Edward AU - Butler, Mary Ann AU - Toennis, Christine A AU - Nemhauser, Jeffrey B AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. mtoraason@cdc.gov Y1 - 2006/01/31/ PY - 2006 DA - 2006 Jan 31 SP - 1 EP - 14 VL - 603 IS - 1 SN - 0027-5107, 0027-5107 KW - Hydrocarbons, Brominated KW - 0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - 1-bromopropane KW - Y9746DNE68 KW - Index Medicus KW - Comet Assay KW - Sex Factors KW - Polymorphism, Genetic KW - Risk Factors KW - Humans KW - Leukocytes KW - Adult KW - Job Description KW - Glutathione Transferase -- genetics KW - Hydrocarbons, Brominated -- adverse effects KW - Male KW - Female KW - Occupational Exposure KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70736891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=DNA+damage+in+leukocytes+of+workers+occupationally+exposed+to+1-bromopropane.&rft.au=Toraason%2C+Mark%3BLynch%2C+Dennis+W%3BDeBord%2C+D+Gayle%3BSingh%2C+Narendra%3BKrieg%2C+Edward%3BButler%2C+Mary+Ann%3BToennis%2C+Christine+A%3BNemhauser%2C+Jeffrey+B&rft.aulast=Toraason&rft.aufirst=Mark&rft.date=2006-01-31&rft.volume=603&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2006-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Shared Use of the IL-10 Receptor-2 Chain by Class- 2 Cytokines T2 - 4th Cytokines and Inflammation Conference AN - 39735533; 4089747 JF - 4th Cytokines and Inflammation Conference AU - Donnelly, Raymond Y1 - 2006/01/30/ PY - 2006 DA - 2006 Jan 30 KW - Interleukin 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39735533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Cytokines+and+Inflammation+Conference&rft.atitle=Shared+Use+of+the+IL-10+Receptor-2+Chain+by+Class-+2+Cytokines&rft.au=Donnelly%2C+Raymond&rft.aulast=Donnelly&rft.aufirst=Raymond&rft.date=2006-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/ebrochure/cytokines%20&%20infl.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. AN - 70680503; 16144704 AB - Dietary methyl group deprivation is now well recognized as a model of hepatocarcinogenesis in rodents. In the present study, we examined the effects of feeding a methyl-deficient diet followed by a methyl-adequate diet on the extent of methylation of liver DNA and on the formation and evolution of altered hepatic foci. Male F344 rats were fed a methyl-deficient diet for 9, 18, 24, and 36 weeks, followed by re-feeding a methyl-adequate diet for a total of 54 weeks. Similar to previous findings, the methyl-deficient diet resulted in decreased levels of S-adenosylmethionine (SAM), SAM/SAH ratios, and global DNA hypomethylation. Feeding the methyl-adequate diet restored the liver SAM levels and SAM/SAH ratios to control levels in all experimental groups. In contrast, re-feeding the complete diet restored DNA methylation to normal level only in the group that had been fed the methyl-deficient diet for 9 weeks; in animals exposed to methyl deprivation longer, the methyl-adequate diet failed to reverse the hypomethylation of DNA. Liver tissue of rats exposed to methyl deficiency for 9, 18, 24, or 36 weeks was characterized by the persistent presence of placental isoform of glutathione-S-transferase (GSTpi)-positive lesions despite re-feeding the methyl-adequate diet. The persistence of altered hepatic foci in liver after withdrawal of methyl-deficient diet serves as an indication of the carcinogenic potential of a methyl-deficient diet. Substitution of the methyl-deficient diet with complete diet failed to prevent the expansion of initiated foci and restore DNA methylation in animals exposed to deficiency for 18, 24, or 36 weeks. The association between DNA hypomethylation and expansion of foci suggests that stable DNA hypomethylation is a promoting factor for clonal expansion of initiated cells. These results provide an experimental evidence and a mechanistic basis by which epigenetic alterations may contribute to the initiation and promotion steps of carcinogenesis. JF - Mutation research AU - Pogribny, Igor P AU - Ross, Sharon A AU - Wise, Carolyn AU - Pogribna, Marta AU - Jones, Elisabeth A AU - Tryndyak, Volodymyr P AU - James, S Jill AU - Dragan, Yvonne P AU - Poirier, Lionel A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Dr., Jefferson, AR 72079, USA. ipogribny@nctr.fda.gov Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 SP - 80 EP - 87 VL - 593 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Glutathione Transferase -- metabolism KW - Male KW - Liver Neoplasms, Experimental -- etiology KW - DNA Methylation KW - Liver Neoplasms, Experimental -- enzymology KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70680503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Irreversible+global+DNA+hypomethylation+as+a+key+step+in+hepatocarcinogenesis+induced+by+dietary+methyl+deficiency.&rft.au=Pogribny%2C+Igor+P%3BRoss%2C+Sharon+A%3BWise%2C+Carolyn%3BPogribna%2C+Marta%3BJones%2C+Elisabeth+A%3BTryndyak%2C+Volodymyr+P%3BJames%2C+S+Jill%3BDragan%2C+Yvonne+P%3BPoirier%2C+Lionel+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2006-01-29&rft.volume=593&rft.issue=1-2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice. AN - 67671370; 16403473 AB - We evaluated regional neuropathological changes in adult and aged male mice treated systemically with kainic acid (KA) in a strain reported to be resistant to excitotoxic neuronal damage, C57BL/6. KA was administered in a single intraperitoneal injection. Adult animals were dosed with 35 mg/kg KA, while aged animals received a dose of 20 mg/kg in order to prevent excessive mortality. At time-points ranging from 12 h to 7 days post-treatment, animals were sacrificed and prepared for histological evaluation utilizing the cupric-silver neurodegeneration stain, immunohistochemistry for GFAP and IgG, and lectin staining. In animals of both ages, KA produced argyrophilia in neurons throughout cortex, hippocampus, thalamus, and amygdala. Semi-quantitative analysis of neuropathology revealed a similar magnitude of damage in animals of both ages, even though aged animals received less toxicant. Additional animals were evaluated for KA-induced reactive gliosis, assayed by an ELISA for GFAP, which revealed a 2-fold elevation in protein levels in adult mice, and a 2.5-fold elevation in aged animals. Histochemical evaluation of GFAP and lectin staining revealed activation of astrocytes and microglia in regions with corresponding argyrophilia. IgG immunostaining revealed a KA-induced breach of the blood-brain barrier in animals of both ages. Our data indicate widespread neurotoxicity following kainic acid treatment in C57BL/6J mice, and reveal increased sensitivity to this excitotoxicant in aged animals. JF - Brain research AU - Benkovic, Stanley Anthony AU - O'Callaghan, James Patrick AU - Miller, Diane Bemis AD - Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention-National Institute for Occupational, Safety and Health, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2006/01/27/ PY - 2006 DA - 2006 Jan 27 SP - 215 EP - 231 VL - 1070 IS - 1 SN - 0006-8993, 0006-8993 KW - Excitatory Amino Acid Agonists KW - 0 KW - Glial Fibrillary Acidic Protein KW - Immunoglobulin G KW - Lectins KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Seizures -- physiopathology KW - Hippocampus -- metabolism KW - Seizures -- etiology KW - Glial Fibrillary Acidic Protein -- metabolism KW - Immunohistochemistry -- methods KW - Mice KW - Nerve Degeneration -- etiology KW - Histocytochemistry -- methods KW - Nerve Degeneration -- pathology KW - Mice, Inbred C57BL KW - Enzyme-Linked Immunosorbent Assay KW - Immunoglobulin G -- metabolism KW - Staining and Labeling KW - Male KW - Excitatory Amino Acid Agonists -- poisoning KW - Kainic Acid -- poisoning KW - Brain -- pathology KW - Aging KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67671370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Regional+neuropathology+following+kainic+acid+intoxication+in+adult+and+aged+C57BL%2F6J+mice.&rft.au=Benkovic%2C+Stanley+Anthony%3BO%27Callaghan%2C+James+Patrick%3BMiller%2C+Diane+Bemis&rft.aulast=Benkovic&rft.aufirst=Stanley&rft.date=2006-01-27&rft.volume=1070&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Computational Modeling of Device-tissue Interface Geometries for Time-resolved Fluorescence in Layered Tissue T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39839563; 4100840 JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Pfefer, J AU - Agrawal, A AU - Drezek, R Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Fluorescence KW - Computer applications KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=Computational+Modeling+of+Device-tissue+Interface+Geometries+for+Time-resolved+Fluorescence+in+Layered+Tissue&rft.au=Pfefer%2C+J%3BAgrawal%2C+A%3BDrezek%2C+R&rft.aulast=Pfefer&rft.aufirst=J&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Electric Field Induced by Light May Explain Cellular Responses to Electromagnetic Energy T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39835802; 4100551 JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Waynant, R W Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Electric fields KW - Light effects KW - Energy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=The+Electric+Field+Induced+by+Light+May+Explain+Cellular+Responses+to+Electromagnetic+Energy&rft.au=Waynant%2C+R+W&rft.aulast=Waynant&rft.aufirst=R&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-resolution Confocal Fiber-optic Biosensing T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39790175; 4100847 DE: JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Ilev, I K AU - Waynant, R W Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39790175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=High-resolution+Confocal+Fiber-optic+Biosensing&rft.au=Ilev%2C+I+K%3BWaynant%2C+R+W&rft.aulast=Ilev&rft.aufirst=I&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. AN - 70699802; 16418464 AB - The US Food and Drug Administration (FDA) licensed recombinant human coagulation factor VIIa (rFVIIa) on March 25, 1999, for bleeding in patients with hemophilia A or B and inhibitors to factors VIII or IX. Use in patients without hemophilia has been increasing since licensure. To review serious thromboembolic adverse events (AEs) reported to the FDA's Adverse Event Reporting System (AERS). The AERS database was reviewed from March 25, 1999, through December 31, 2004, for thromboembolic AE reports with rFVIIa. The AERS database includes US and non-US spontaneous AE reports from both approved (specific indications for patients with hemophilia) and unlabeled uses. It also includes serious AEs in patients enrolled in postlicensure clinical trials who received rFVIIa. Manufacturer reporting to FDA is mandatory, but primary notification from clinicians and others to FDA or manufacturers is voluntary for spontaneous reports; therefore, AERS underrepresents actual event occurrences. Reported thromboembolic events occurring in patients administered rFVIIa. A total of 431 AE reports for rFVIIa were found, of which 168 reports described 185 thromboembolic events. Seventeen events occurred in patients with hemophilia and 59 occurred in patients enrolled in postlicensure trials. Unlabeled indications accounted for 151 of the reports, most with active bleeding (n = 115). Reported AEs were thromboembolic cerebrovascular accident (n = 39), acute myocardial infarction (n = 34), other arterial thromboses (n = 26), pulmonary embolism (n = 32), other venous thromboses (including deep vein thrombosis) (n = 42), and clotted devices (n = 10). In 36 (72%) of 50 reported deaths, the probable cause of death was the thromboembolic event. In 144 patients with timing information, 73 events (52%) occurred in the first 24 hours after the last dose (30 events within 2 hours). Sixty-four reports (38%) noted concomitant use of hemostatic agents. Most reports lacked sufficient information to evaluate potential dosage associations. Most reported thromboembolic AEs followed the use of rFVIIa for unlabeled indications and occurred in arterial and venous systems, often resulting in serious morbidity and mortality. Analysis of the relationship between AEs and rFVIIa is hindered by concomitant medications, preexisting medical conditions, confounding by indication, and inherent limitations of passive surveillance. Randomized controlled trials are needed to establish the safety and efficacy of rFVIIa in patients without hemophilia. JF - JAMA AU - O'Connell, Kathryn A AU - Wood, Jennifer J AU - Wise, Robert P AU - Lozier, Jay N AU - Braun, M Miles AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md 20852-1448, USA. oconnellk@cber.fda.gov Y1 - 2006/01/18/ PY - 2006 DA - 2006 Jan 18 SP - 293 EP - 298 VL - 295 IS - 3 KW - Recombinant Proteins KW - 0 KW - Factor VIIa KW - EC 3.4.21.21 KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Aged, 80 and over KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Adult KW - Infant, Newborn KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Child, Preschool KW - Thromboembolism -- epidemiology KW - Factor VIIa -- therapeutic use KW - Recombinant Proteins -- adverse effects KW - Thromboembolism -- chemically induced KW - Recombinant Proteins -- therapeutic use KW - Factor VIIa -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70699802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Thromboembolic+adverse+events+after+use+of+recombinant+human+coagulation+factor+VIIa.&rft.au=O%27Connell%2C+Kathryn+A%3BWood%2C+Jennifer+J%3BWise%2C+Robert+P%3BLozier%2C+Jay+N%3BBraun%2C+M+Miles&rft.aulast=O%27Connell&rft.aufirst=Kathryn&rft.date=2006-01-18&rft.volume=295&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2006 Jul 5;296(1):43-4; author reply 44 [16820543] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine. AN - 67574841; 16356839 AB - Pyrrolizidine alkaloids (PAs) are probably the most common poisonous plants affecting livestock, wildlife, and humans. The PAs that have been found to be tumorigenic in experimental animals belong to the retronecine-, heliotridine-, and otonecine-type PAs. Our recent mechanistic studies indicated that riddelliine, a tumorigenic retronecine-type PA, induced tumors via a genotoxic mechanism mediated by the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. The same adducts were formed from clivorine, a tumorigenic otonecine-type PA from metabolism of clivorine by rat liver microsomes in the presence of calf thymus DNA. In this study, we report that metabolism of lasiocarpine, the prototype heliotridine PA, by F344 rat liver microsomes resulted in the formation of DHP. When incubated in the presence of calf thymus DNA, the same DHP-derived DNA adducts were formed. These results suggest that these DHP-derived DNA adducts are potential biomarkers of exposure and tumorigenicity for all types of PAs. JF - Cancer letters AU - Xia, Qingsu AU - Chou, Ming W AU - Edgar, John A AU - Doerge, Daniel R AU - Fu, Peter P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3,900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA. Y1 - 2006/01/08/ PY - 2006 DA - 2006 Jan 08 SP - 138 EP - 145 VL - 231 IS - 1 SN - 0304-3835, 0304-3835 KW - Biomarkers KW - 0 KW - Carcinogens KW - DNA Adducts KW - Pyrrolizidine Alkaloids KW - Monocrotaline KW - 73077K8HYV KW - dehydroretronecine KW - QG6MWR17OH KW - lasiocarpine KW - S770100Q96 KW - Index Medicus KW - Rats KW - Microsomes, Liver KW - Animals KW - Rats, Inbred F344 KW - Male KW - Monocrotaline -- metabolism KW - Carcinogens -- pharmacology KW - Carcinogens -- metabolism KW - Monocrotaline -- analogs & derivatives KW - Pyrrolizidine Alkaloids -- metabolism KW - Monocrotaline -- pharmacology KW - Pyrrolizidine Alkaloids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67574841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Formation+of+DHP-derived+DNA+adducts+from+metabolic+activation+of+the+prototype+heliotridine-type+pyrrolizidine+alkaloid%2C+lasiocarpine.&rft.au=Xia%2C+Qingsu%3BChou%2C+Ming+W%3BEdgar%2C+John+A%3BDoerge%2C+Daniel+R%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2006-01-08&rft.volume=231&rft.issue=1&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2005-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations. AN - 67603585; 16391368 AB - Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled "Cancer Survivorship--Genetic Susceptibility and Second Primary Cancers." These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer. JF - Journal of the National Cancer Institute AU - Travis, Lois B AU - Rabkin, Charles S AU - Brown, Linda Morris AU - Allan, James M AU - Alter, Blanche P AU - Ambrosone, Christine B AU - Begg, Colin B AU - Caporaso, Neil AU - Chanock, Stephen AU - DeMichele, Angela AU - Figg, William Douglas AU - Gospodarowicz, Mary K AU - Hall, Eric J AU - Hisada, Michie AU - Inskip, Peter AU - Kleinerman, Ruth AU - Little, John B AU - Malkin, David AU - Ng, Andrea K AU - Offit, Kenneth AU - Pui, Ching-Hon AU - Robison, Leslie L AU - Rothman, Nathaniel AU - Shields, Peter G AU - Strong, Louise AU - Taniguchi, Toshiyasu AU - Tucker, Margaret A AU - Greene, Mark H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. travisl@mail.nih.gov Y1 - 2006/01/04/ PY - 2006 DA - 2006 Jan 04 SP - 15 EP - 25 VL - 98 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Carcinogens KW - Index Medicus KW - Multicenter Studies as Topic KW - Humans KW - Medical Informatics KW - Specimen Handling KW - Clinical Trials as Topic KW - Congresses as Topic KW - Antineoplastic Agents -- adverse effects KW - Radiotherapy -- adverse effects KW - Registries KW - Syndrome KW - Cohort Studies KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - United States -- epidemiology KW - Biotechnology KW - Survivors -- statistics & numerical data KW - Neoplasms -- drug therapy KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms -- radiotherapy KW - Neoplasms, Second Primary -- etiology KW - Neoplasms -- mortality KW - Neoplasms, Second Primary -- genetics KW - Neoplasms, Radiation-Induced -- chemically induced KW - Neoplasms, Radiation-Induced -- genetics KW - Neoplasms, Second Primary -- chemically induced KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67603585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cancer+survivorship--genetic+susceptibility+and+second+primary+cancers%3A+research+strategies+and+recommendations.&rft.au=Travis%2C+Lois+B%3BRabkin%2C+Charles+S%3BBrown%2C+Linda+Morris%3BAllan%2C+James+M%3BAlter%2C+Blanche+P%3BAmbrosone%2C+Christine+B%3BBegg%2C+Colin+B%3BCaporaso%2C+Neil%3BChanock%2C+Stephen%3BDeMichele%2C+Angela%3BFigg%2C+William+Douglas%3BGospodarowicz%2C+Mary+K%3BHall%2C+Eric+J%3BHisada%2C+Michie%3BInskip%2C+Peter%3BKleinerman%2C+Ruth%3BLittle%2C+John+B%3BMalkin%2C+David%3BNg%2C+Andrea+K%3BOffit%2C+Kenneth%3BPui%2C+Ching-Hon%3BRobison%2C+Leslie+L%3BRothman%2C+Nathaniel%3BShields%2C+Peter+G%3BStrong%2C+Louise%3BTaniguchi%2C+Toshiyasu%3BTucker%2C+Margaret+A%3BGreene%2C+Mark+H&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2006-01-04&rft.volume=98&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Raising the Bar for Levees AN - 743426522; 201004-31-0296940 (CE); 12085823 (EN) AB - Engineers have worked for millennia to control natural flooding through dams and levees. While the fundamental principles and challenges of holding back water have not changed, the tools brought to the task continue to evolve. Among other tools being tested and implemented today are elaborate sensors to detect stresses and strains within structures, and impermeable lining materials known as geomembranes, which are laid underneath the structure before it is built to prevent water seepage. JF - Environmental Health Perspectives AU - Lougheed, Tim PY - 2006 SP - A44 EP - A47 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Levees KW - Health KW - Tasks KW - Copyrights KW - Flooding KW - Dam engineering KW - Dams KW - Strain KW - Seepage KW - Sensors KW - Stresses KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743426522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Raising+the+Bar+for+Levees&rft.au=Lougheed%2C+Tim&rft.aulast=Lougheed&rft.aufirst=Tim&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=A44&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Note from the Editor: Looking Forward AN - 743342398; 201004-31-0296951 (CE); 12085834 (EN) AB - With this issue EHP bids a warm goodbye to Tom Goehl, our Editor-in-Chief since October 2001. Tom is a true altruist, always believing that the role of EHP is to impact the human condition by providing a forum for scientific information to be used by researchers, policy makers, and individuals to improve human health around the world. His devotion, drive, and integrity in working toward this goal are unmatched. I have no doubt that Tom will continue to be a dedicated contributor to global environmental health, though he claims it may be from a secluded camping spot far, far away. Farewell and safe journeys! JF - Environmental Health Perspectives AU - Burkhart, James G PY - 2006 SP - a13 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Human KW - Copyrights KW - Policies KW - Editors KW - Journeys KW - Integrity KW - Safes KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743342398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Note+from+the+Editor%3A+Looking+Forward&rft.au=Burkhart%2C+James+G&rft.aulast=Burkhart&rft.aufirst=James&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=a13&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - In Katrina's Wake AN - 743325013; 201004-31-0296944 (CE); 12085827 (EN) AB - When Hurricane Katrina made landfall on the Gulf Coast on 29 August 2005, it was the beginning of a grueling lesson in the myriad ways the environment can harm human health. The ravaged communities left in the storm's wake are still assessing the environmental health impacts of the winds, waves, and flooding that occurred. Various teams of researchers are sampling floodwaters, sediments, and other materials to determine the habitability of the area, which was home to hundreds of petroleum and chemical facilities. Agencies are working to ensure that workers and homeowners are protected from the risks they may encounter in the post-hurricane environment. Much remains to be sorted out, such as how best to rebuild the affected area, protect coastal cities from future flooding, and prepare responders for future events. JF - Environmental Health Perspectives AU - Manuel, John PY - 2006 SP - A32 EP - A39 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Wakes KW - Flooding KW - Sampling KW - Coastal KW - Risk KW - Encounters KW - Gulfs KW - Crude oil KW - Floodwaters KW - Hurricanes KW - Sediments KW - Communities KW - Coastal environments KW - Environmental impact KW - Copyrights KW - Human KW - Habitability KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743325013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In+Katrina%27s+Wake&rft.au=Manuel%2C+John&rft.aulast=Manuel&rft.aufirst=John&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=A32&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Louisiana's Wetlands: A Lesson in Nature Appreciation AN - 743266556; 201004-31-0296941 (CE); 12085824 (EN) AB - The Mississippi River is one of the most intensively engineered places in the United States, both to facilitate navigation of the river and to keep it from flooding. As a result, large chunks of the state's marshes and wetlands, which once protected coastal communities from hurricanes, have disappeared in the last century. Several recent reports have focused on the wetland loss and the potential for restoring them, and some limited governmental efforts have already addressed rebuilding Louisiana's wetlands. The losses inflicted by Hurricane Katrina have added urgency to finding ways to restore this natural defense system. JF - Environmental Health Perspectives AU - Tibbetts, John PY - 2006 SP - A40 EP - A43 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Wetlands KW - Rivers KW - Health KW - Hurricanes KW - Navigation KW - Marshes KW - Communities KW - Copyrights KW - Flooding KW - Renovating KW - Coastal KW - Urgency KW - Rebuilding KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743266556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Louisiana%27s+Wetlands%3A+A+Lesson+in+Nature+Appreciation&rft.au=Tibbetts%2C+John&rft.aulast=Tibbetts&rft.aufirst=John&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=A40&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - January 2006 NIEHS News. AN - 743246080; 201004-31-0297126 (CE); 12086423 (EN) AB - Brief articles on: NIEHS Responds to Katrina; Beyond the Bench: COEPs Contribute to Hurricane Relief; Headliners: Lead Disrupts T Cell Function. JF - Environmental Health Perspectives AU - R, Twombly AU - T, Tillett PY - 2006 SP - A28 EP - A29 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Copyrights KW - Medicine KW - Libraries KW - Health KW - Hurricanes KW - Benches KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743246080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=January+2006+NIEHS+News.&rft.au=R%2C+Twombly%3BT%2C+Tillett&rft.aulast=R&rft.aufirst=Twombly&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=A28&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Handbook of Urban Health: Populations, Methods, and Practice AN - 743161325; 201004-31-0296925 (CE); 12085808 (EN) AB - The world is undergoing major urbanization. Within 25 years, more than half the world's population will be living in urban areas, and in this period approximately 1 million people will be added to city populations each week. Urban health is thus significant for population health, and this handbook provides a timely review of the issues involved. JF - Environmental Health Perspectives AU - Kjellstrom, Tord PY - 2006 SP - a64 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Populations KW - Handbooks KW - Copyrights KW - Urbanization KW - Urban areas KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743161325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Handbook+of+Urban+Health%3A+Populations%2C+Methods%2C+and+Practice&rft.au=Kjellstrom%2C+Tord&rft.aulast=Kjellstrom&rft.aufirst=Tord&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=a64&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The influence of dietary intake on the progression and severity of mycobacteriosis in striped bass (Morone saxatilis) AN - 742897965; 2007-047343 JF - Scientific Investigations Report AU - Jacobs, John M AU - Baya, Ana M AU - Rhodes, Martha W AU - Reimschuessel, Renate AU - Harrell, Reginal M Y1 - 2006 PY - 2006 DA - 2006 SP - 19 EP - 20 PB - U. S. Geological Survey, Reston, VA SN - 2328-031X, 2328-031X KW - United States KW - Chordata KW - Chesapeake Bay KW - diet KW - diseases KW - Pisces KW - Morone saxatilis KW - ecology KW - Vertebrata KW - USGS KW - biology KW - mycobacteriosis KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742897965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+Investigations+Report&rft.atitle=The+influence+of+dietary+intake+on+the+progression+and+severity+of+mycobacteriosis+in+striped+bass+%28Morone+saxatilis%29&rft.au=Jacobs%2C+John+M%3BBaya%2C+Ana+M%3BRhodes%2C+Martha+W%3BReimschuessel%2C+Renate%3BHarrell%2C+Reginal+M&rft.aulast=Jacobs&rft.aufirst=John&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Scientific+Investigations+Report&rft.issn=2328031X&rft_id=info:doi/ L2 - http://www.usgs.pubs LA - English DB - GeoRef N1 - Conference title - USGS/NOAA workshop on Mycobacteriosis in striped bass N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 1 N1 - PubXState - VA N1 - SuppNotes - Accessed on April 23, 2007 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - biology; Chesapeake Bay; Chordata; diet; diseases; ecology; Morone saxatilis; mycobacteriosis; Pisces; United States; USGS; Vertebrata ER - TY - JOUR T1 - Validation of a PCR-based method for the detection of various rendered materials in feedstuffs using a forensic DNA extraction kit. AN - 70690146; 16416920 AB - A method trial was initiated to validate the use of a commercial DNA forensic kit to extract DNA from animal feed as part of a PCR-based method. Four different PCR primer pairs (one bovine pair, one porcine pair, one ovine primer pair, and one multispecies pair) were also evaluated. Each laboratory was required to analyze a total of 120 dairy feed samples either not fortified (control, true negative) or fortified with bovine meat and bone meal, porcine meat and bone meal (PMBM), or lamb meal. Feeds were fortified with the animal meals at a concentration of 0.1% (wt/wt). Ten laboratories participated in this trial, and each laboratory was required to evaluate two different primer pairs, i.e., each PCR primer pair was evaluated by five different laboratories. The method was considered to be validated for a given animal source when three or more laboratories achieved at least 97% accuracy (29 correct of 30 samples for 96.7% accuracy, rounded up to 97%) in detecting the fortified samples for that source. Using this criterion, the method was validated for the bovine primer because three laboratories met the criterion, with an average accuracy of 98.9%. The average false-positive rate was 3.0% in these laboratories. A fourth laboratory was 80% accurate in identifying the samples fortified with bovine meat and bone meal. A fifth laboratory was not able to consistently extract the DNA from the feed samples and did not achieve the criterion for accuracy for either the bovine or multispecies PCR primers. For the porcine primers, the method was validated, with four laboratories meeting the criterion for accuracy with an average accuracy of 99.2%. The fifth laboratory had a 93.3% accuracy outcome for the porcine primer. Collectively, these five laboratories had a 1.3% false-positive rate for the porcine primer. No laboratory was able to meet the criterion for accuracy with the ovine primers, most likely because of problems with the synthesis of the primer pair; none of the positive control DNA samples could be detected with the ovine primers. The multispecies primer pair was validated in three laboratories for use with bovine meat and bone meal and lamb meal but not with PMBM. The three laboratories had an average accuracy of 98.9% for bovine meat and bone meal, 97.8% for lamb meal, and 63.3% for PMBM. When examined on an individual laboratory basis, one of these four laboratories could not identify a single feed sample containing PMBM by using the multispecies primer, whereas the other laboratory identified only one PMBM-fortified sample, suggesting that the limit of detection for PMBM with this primer pair is around 0.1% (wt/wt). The results of this study demonstrated that the DNA forensic kit can be used to extract DNA from animal feed, which can then be used for PCR analysis to detect animal-derived protein present in the feed sample. JF - Journal of food protection AU - Myers, Michael J AU - Yancy, Haile F AU - Araneta, Michael AU - Armour, Jennifer AU - Derr, Janice AU - Hoostelaere, Lawrence A D AU - Farmer, Doris AU - Jackson, Falana AU - Kiessling, William M AU - Koch, Henry AU - Lin, Huahua AU - Liu, Yan AU - Mowlds, Gabrielle AU - Pinero, David AU - Riter, Ken L AU - Sedwick, John AU - Shen, Yuelian AU - Wetherington, June AU - Younkins, Ronsha AD - US. Food and Drug Administration, Center for Veterinary Medicine, Laurel, Maryland 20708, USA. mmyers@cvm.fda.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 205 EP - 210 VL - 69 IS - 1 SN - 0362-028X, 0362-028X KW - DNA Primers KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Swine KW - Sensitivity and Specificity KW - Animals KW - Cattle KW - Sheep KW - Humans KW - Encephalopathy, Bovine Spongiform -- transmission KW - Time Factors KW - Species Specificity KW - Encephalopathy, Bovine Spongiform -- prevention & control KW - False Positive Reactions KW - Polymerase Chain Reaction -- methods KW - Food Contamination -- analysis KW - DNA -- analysis KW - Animal Feed -- analysis KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70690146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Validation+of+a+PCR-based+method+for+the+detection+of+various+rendered+materials+in+feedstuffs+using+a+forensic+DNA+extraction+kit.&rft.au=Myers%2C+Michael+J%3BYancy%2C+Haile+F%3BAraneta%2C+Michael%3BArmour%2C+Jennifer%3BDerr%2C+Janice%3BHoostelaere%2C+Lawrence+A+D%3BFarmer%2C+Doris%3BJackson%2C+Falana%3BKiessling%2C+William+M%3BKoch%2C+Henry%3BLin%2C+Huahua%3BLiu%2C+Yan%3BMowlds%2C+Gabrielle%3BPinero%2C+David%3BRiter%2C+Ken+L%3BSedwick%2C+John%3BShen%2C+Yuelian%3BWetherington%2C+June%3BYounkins%2C+Ronsha&rft.aulast=Myers&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=69&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast implant surveillance reports to the U.S. Food and Drug Administration: maternal-child health problems. AN - 69027159; 17073570 AB - There is continuing concern that women who receive breast implants may be at increased risk for adverse reproductive outcomes or experience problems with breastfeeding. It is unknown whether exposure to biomaterials in breast implants may have teratogenic effects or leach into breast milk causing postnatalproblems. We studied the Food and Drug Administration (FDA) experience by analyzing a case series of adverse event reports received and entered into the FDA's Manufacturer and User Facility Device Experience (MAUDE) database or the Device Experience Network (DEN) database by December 31, 2002 regarding women with breast implants. Reports were critically reviewed for lactation difficulties, reproductive problems (spontaneous abortion, delayed conception) and medical conditions among offspring, including neonatal, infant, and childhood diseases and congenital defects that were attributed to implants. We identified 339 reports that described maternal-child adverse events. Nearly half of these reports (46%) described actual problems with breastfeeding or expressed concern that implants would be unsafe or interfere with breastfeeding. Forty-four percent of reports (n=149) described either nonspecific or specific signs, symptoms, or illnesses in children. An additional 3.5% of reports (n=12) detailed a congenital anomaly believed by the reporter to be caused by breast implants. JF - Journal of long-term effects of medical implants AU - Brown, S Lori AU - Todd, Joan Ferlo AU - Cope, Judith U AU - Sachs, Hari Cheryl AD - Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Center for Devices and Radiological Health Food and Drug Administration, Seattle District Office, Bothell, WA 98021-4421, USA. lori.brown@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 281 EP - 290 VL - 16 IS - 4 SN - 1050-6934, 1050-6934 KW - Silicone Gels KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Health technology assessment KW - United States KW - Pregnancy Complications -- etiology KW - Humans KW - Infertility, Female -- etiology KW - Infant, Newborn KW - Child KW - Congenital Abnormalities -- etiology KW - Child, Preschool KW - Pregnancy KW - Infant KW - United States Food and Drug Administration KW - Risk Factors KW - Databases, Factual KW - Adolescent KW - Female KW - Male KW - Breast Feeding KW - Breast Implantation -- adverse effects KW - Prenatal Exposure Delayed Effects KW - Breast Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+long-term+effects+of+medical+implants&rft.atitle=Breast+implant+surveillance+reports+to+the+U.S.+Food+and+Drug+Administration%3A+maternal-child+health+problems.&rft.au=Brown%2C+S+Lori%3BTodd%2C+Joan+Ferlo%3BCope%2C+Judith+U%3BSachs%2C+Hari+Cheryl&rft.aulast=Brown&rft.aufirst=S&rft.date=2006-01-01&rft.volume=16&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+long-term+effects+of+medical+implants&rft.issn=10506934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice. AN - 68644659; 16844664 AB - It has been suggested that welding fume (WF) exposure increases lung cancer risk in welders. Epidemiology studies have failed to conclude that WF alone causes lung cancer and animal studies are lacking. We examined the course of inflammation, damage, and repair in the lungs of A/J mice, a lung tumor susceptible strain, caused by stainless steel WF. Mice were exposed by pharyngeal aspiration to 40 mg/kg of WF, silica, or saline. Bronchoalveolar lavage (BAL) was performed 24 hours, 1 and 16 weeks to assess lung injury and inflammation and histopathology was done 1, 8, 16, 24, and 48 weeks postexposure. Both exposures increased inflammatory cells, lactate dehydrogenase and albumin at 24 hr and 1 week. At 16 weeks, these parameters remained elevated in silica-exposed but not WF-exposed mice. Histopathologic evaluation at 1 week indicated that WF induced bronchiolar epithelial hyperplasia with associated cellular atypia, alveolar bronchiolo-alveolar hyperplasia (BAH) in peribronchiolar alveoli, and peribronchiolar lymphogranulomatous inflammation. Persistent changes included foci of histiocytic inflammation, fibrosis, atypical bronchiolar epithelial cells, and bronchiolar BAH. The principle changes in silica-exposed mice were histiocytic and suppurative inflammation, fibrosis, and alveolar BAH. Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure. JF - Toxicologic pathology AU - Solano-Lopez, Claudia AU - Zeidler-Erdely, Patti C AU - Hubbs, Ann F AU - Reynolds, Steven H AU - Roberts, Jenny R AU - Taylor, Michael D AU - Young, Shih-Houng AU - Castranova, Vincent AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. jga6@cdc.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 364 EP - 372 VL - 34 IS - 4 SN - 0192-6233, 0192-6233 KW - Gases KW - 0 KW - Stainless Steel KW - 12597-68-1 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Animals KW - Hyperplasia -- pathology KW - Gases -- chemistry KW - Stainless Steel -- toxicity KW - Particle Size KW - Silicon Dioxide -- toxicity KW - Mice KW - Gases -- toxicity KW - Mice, Inbred A KW - Hyperplasia -- chemically induced KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Inhalation Exposure KW - Lung -- drug effects KW - Welding KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- chemically induced KW - Lung -- pathology KW - Genetic Predisposition to Disease KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Welding+fume+exposure+and+associated+inflammatory+and+hyperplastic+changes+in+the+lungs+of+tumor+susceptible+a%2Fj+mice.&rft.au=Solano-Lopez%2C+Claudia%3BZeidler-Erdely%2C+Patti+C%3BHubbs%2C+Ann+F%3BReynolds%2C+Steven+H%3BRoberts%2C+Jenny+R%3BTaylor%2C+Michael+D%3BYoung%2C+Shih-Houng%3BCastranova%2C+Vincent%3BAntonini%2C+James+M&rft.aulast=Solano-Lopez&rft.aufirst=Claudia&rft.date=2006-01-01&rft.volume=34&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health impact assessment in New Zealand. AN - 68609805; 16826698 AB - Health impact assessment (HIA) has its origins in environmental impact assessment methodology. New Zealand's approach to health impact assessment is consistent with other countries. During the 1990s, legislation that related to the management of natural and physical resources provided the basis for public health engagement in impact assessment. In the mid 1990s, the Public Health Commission released guidelines on health impact assessment that adopted a risk assessment approach and was aimed at particular environmental projects. The transition to policy-level impact assessment occurred in 2000 with the national health strategy identifying impact assessment as one its key objectives. Guidelines developed by the Public Health Advisory Committee in 2004 have been applied in a small number of policy-level health impact assessments in New Zealand. One of these projects was the review of a Liveable Communities Plan, a policy proposal for town centre growth and development. JF - Epidemiologia e prevenzione AU - Soeberg, Matthew AD - Auckland Regional Public Health Service, New Zealand. msoeberg@adhb.govt.nz PY - 2006 SP - 41 EP - 45 VL - 30 IS - 1 SN - 1120-9763, 1120-9763 KW - Index Medicus KW - Public Health KW - Humans KW - Public Policy KW - Health Policy KW - New Zealand -- epidemiology KW - Environmental Illness -- epidemiology KW - Health Status UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68609805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiologia+e+prevenzione&rft.atitle=Health+impact+assessment+in+New+Zealand.&rft.au=Soeberg%2C+Matthew&rft.aulast=Soeberg&rft.aufirst=Matthew&rft.date=2006-01-01&rft.volume=30&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Epidemiologia+e+prevenzione&rft.issn=11209763&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of statistical methods for estimation of less than detectable ionising radiation exposures. AN - 68272761; 16517566 AB - Methods were developed to estimate the ionising radiation dose below the detection level (DL) of personal monitoring devices for a case-control study of protracted radiation exposure and lung cancer. Exposure data were grouped by dosemeter type and monitoring period. Each group contained dosimetry data that were interval-censored from limitations in measurement precision and included left-censoring of observations below detection. The grouped data were fit to a three parameter hybrid-lognormal distribution by maximum likelihood estimation. Using the fitted distribution, bootstrap samples were either simulated by Monte Carlo or constructed by sampling with replacement. The resulting bootstrap sample distributions were then used to predict the missing dose values and the associated uncertainty in the estimate. Among study subjects, 1357 workers were monitored with film dosimetry. Among the 39,263 dose observations 20,416 were recorded as zero dose, indicating 52% left-censoring. The statistical methods estimated 0.31 person-Sv below the DL or approximately 1% of the total collective dose for this study population. JF - Radiation protection dosimetry AU - Daniels, Robert D AU - Yiin, James H AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. rtd2@cdc.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 240 EP - 251 VL - 121 IS - 3 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - Ships KW - Humans KW - Case-Control Studies KW - Lung Neoplasms -- mortality KW - Risk Assessment KW - Radiation, Ionizing KW - Occupational Exposure -- statistics & numerical data KW - Film Dosimetry -- instrumentation KW - Neoplasms, Radiation-Induced -- mortality KW - Models, Statistical KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68272761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=A+comparison+of+statistical+methods+for+estimation+of+less+than+detectable+ionising+radiation+exposures.&rft.au=Daniels%2C+Robert+D%3BYiin%2C+James+H&rft.aulast=Daniels&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=121&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal work-related injuries in the agriculture production sector among youth in the United States, 1992-2002. AN - 68203236; 17135143 AB - Youth working on farms face unique risks that are not present for many other young workers, including machinery, large animals, electrical hazards, chemical hazards and excessive noise. This research identified the number and rate of occupational fatalities for youth working in the agriculture production industry, which is most closely affiliated with farming, for the years 1992-2002. The Census of Fatal Occupational Injuries (CFOI), developed by the Bureau of Labor Statistics (BLS), was the database used for the analysis. There were 310 work-related deaths to youth less than 20 years of age from 1992 through 2002 in the agriculture production sector. This compares to 1,958 total fatalities for all workers less than 20 years of age for the same time period. The number of agricultural production fatalities to youth has shown a general downward trend over this time period. The rates were higher for young workers in agriculture production than for young workers in all industries by a factor of 3.6. Fifteen year olds had the highest fatality rates with the crop production sector having a rate six times that of all 15 year old workers. The objective of this descriptive research was to identify, prioritize and publicize the risks to children and youth who work on farms in order to provide public health and safety professionals relevant information upon which to base decisions for interventions or other prevention activities for this priority population. This research also has direct applications for farm parents and safety and health professionals who work with the priority population of young agricultural workers. JF - Journal of agromedicine AU - Hard, David L AU - Myers, John R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, WV 26505, USA. DHard@cdc.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 57 EP - 65 VL - 11 IS - 2 SN - 1059-924X, 1059-924X KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Safety KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Cause of Death KW - Age Distribution KW - Agriculture KW - Accidents, Occupational -- trends KW - Accidents, Occupational -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68203236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Fatal+work-related+injuries+in+the+agriculture+production+sector+among+youth+in+the+United+States%2C+1992-2002.&rft.au=Hard%2C+David+L%3BMyers%2C+John+R&rft.aulast=Hard&rft.aufirst=David&rft.date=2006-01-01&rft.volume=11&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1059924X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proposed NSAID package insert labeling. AN - 67958602; 16687359 AB - The United States Food and Drug Administration (FDA) has proposed new label warnings for all nonsteroidal anti-inflammatory drugs (NSAIDs) to warn about potential cardiovascular and other toxicities associated with these medications. The proposed label requirements are presented. JF - Journal of pain & palliative care pharmacotherapy AU - Food and Drug Administration U.S. Public Health Service AD - Food and Drug Administration U.S. Public Health Service Y1 - 2006 PY - 2006 DA - 2006 SP - 49 EP - 55 VL - 20 IS - 1 SN - 1536-0288, 1536-0288 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - United States KW - Drug Interactions KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Drug Labeling -- legislation & jurisprudence KW - United States Food and Drug Administration -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67958602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Proposed+NSAID+package+insert+labeling.&rft.au=Food+and+Drug+Administration+U.S.+Public+Health+Service&rft.aulast=Food+and+Drug+Administration+U.S.+Public+Health+Service&rft.aufirst=&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=15360288&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-21 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Scientific perspectives on drug transporters and their role in drug interactions. AN - 67956381; 16686370 AB - Recently, increased interest in drug transporters and research in this area has revealed that drug transporters play an important role in modulating drug absorption, distribution, and elimination. Acting alone or in concert with drug metabolizing enzymes they can affect the pharmacokinetics and pharmacodynamics of a drug. This commentary will focus on the potential role that drug transporters may play in drug-drug interactions and what information may be needed during drug development and new drug application (NDA) submissions to address potential drug interactions mediated by transporters. JF - Molecular pharmaceutics AU - Zhang, Lei AU - Strong, John M AU - Qiu, Wei AU - Lesko, Lawrence J AU - Huang, Shiew-Mei AD - Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. PY - 2006 SP - 62 EP - 69 VL - 3 IS - 1 SN - 1543-8384, 1543-8384 KW - Membrane Transport Proteins KW - 0 KW - Index Medicus KW - Humans KW - Structure-Activity Relationship KW - Drug Interactions KW - Membrane Transport Proteins -- chemistry KW - Membrane Transport Proteins -- physiology KW - Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67956381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmaceutics&rft.atitle=Scientific+perspectives+on+drug+transporters+and+their+role+in+drug+interactions.&rft.au=Zhang%2C+Lei%3BStrong%2C+John+M%3BQiu%2C+Wei%3BLesko%2C+Lawrence+J%3BHuang%2C+Shiew-Mei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2006-01-01&rft.volume=3&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmaceutics&rft.issn=15438384&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra. AN - 67947756; 16628570 AB - Robust, specific, and rapid identification of toxic strains of bacteria and viruses, to guide the mitigation of their adverse health effects and optimum implementation of other response actions, remains a major analytical challenge. This need has driven the development of methods for classification of microorganisms using mass spectrometry, particularly matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), that allows high-throughput analyses with minimum sample preparation. We describe a novel approach to cell typing based on pattern recognition of MALDI mass spectra, which involves charge-state deconvolution in conjunction with a new correlation analysis procedure. The method is applicable to both prokaryotic and eukaryotic cells. Charge-state deconvolution improves the quantitative reproducibility of spectra because multiply charged ions resulting from the same biomarker attaching a different number of protons are recognized and their abundances are combined. This allows a clearer distinction of bacterial strains or of cancerous and normal liver cells. Improved class distinction provided by charge-state deconvolution was demonstrated by cluster spacing on canonical variate score charts and by correlation analyses. Deconvolution may enhance detection of early disease state or therapy progress markers in various tissues analyzed by MALDI-MS. JF - Rapid communications in mass spectrometry : RCM AU - Wilkes, Jon G AU - Buzatu, Dan A AU - Dare, Diane J AU - Dragan, Yvonne P AU - Chiarelli, M Paul AU - Holland, Ricky D AU - Beaudoin, Michael AU - Heinze, Thomas M AU - Nayak, Rajesh AU - Shvartsburg, Alexandre A AD - National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. jon.wilkes@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1595 EP - 1603 VL - 20 IS - 10 SN - 0951-4198, 0951-4198 KW - Index Medicus KW - Animals KW - Eukaryotic Cells -- chemistry KW - Liver -- cytology KW - Algorithms KW - Citrobacter -- classification KW - Salmonella enterica -- chemistry KW - Salmonella enterica -- classification KW - Citrobacter -- chemistry KW - Liver -- chemistry KW - Bacteria -- chemistry KW - Rats KW - Rats, Sprague-Dawley KW - Eukaryotic Cells -- classification KW - Bacteria -- classification KW - Cells -- classification KW - Cells -- chemistry KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- statistics & numerical data KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67947756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Improved+cell+typing+by+charge-state+deconvolution+of+matrix-assisted+laser+desorption%2Fionization+mass+spectra.&rft.au=Wilkes%2C+Jon+G%3BBuzatu%2C+Dan+A%3BDare%2C+Diane+J%3BDragan%2C+Yvonne+P%3BChiarelli%2C+M+Paul%3BHolland%2C+Ricky+D%3BBeaudoin%2C+Michael%3BHeinze%2C+Thomas+M%3BNayak%2C+Rajesh%3BShvartsburg%2C+Alexandre+A&rft.aulast=Wilkes&rft.aufirst=Jon&rft.date=2006-01-01&rft.volume=20&rft.issue=10&rft.spage=1595&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis. AN - 67930375; 16669178 AB - The purpose of this study was to describe and compare the cardiac magnetic resonance (CMR) characteristics of myocarditis caused by high dose interleukin-2 (7 patients) with community-acquired myocarditis (14 patients). A total of 21 patients with suspected myocarditis and elevated cardiac enzymes underwent cine CMR followed by delayed enhancement. The mean ejection fraction was mildly decreased in both groups. The location, pattern, and extent of DE were similar in both groups of patients. The CMR similarities between these two populations suggest that cytokine-mediated cytotoxicity may play an important role in community-acquired myocarditis. JF - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance AU - Ingkanisorn, W Patricia AU - Paterson, D Ian AU - Calvo, Katherine R AU - Rosing, Douglas R AU - Schwartzentruber, Douglas J AU - Fuisz, Anthon R AU - Arai, Andrew E AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1061, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 353 EP - 360 VL - 8 IS - 2 SN - 1097-6647, 1097-6647 KW - Antineoplastic Agents KW - 0 KW - Interleukin-2 KW - Index Medicus KW - Humans KW - Melanoma -- drug therapy KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Statistics, Nonparametric KW - Male KW - Female KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Magnetic Resonance Imaging, Cine -- methods KW - Myocarditis -- chemically induced KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+magnetic+resonance+%3A+official+journal+of+the+Society+for+Cardiovascular+Magnetic+Resonance&rft.atitle=Cardiac+magnetic+resonance+appearance+of+myocarditis+caused+by+high+dose+IL-2%3A+similarities+to+community-acquired+myocarditis.&rft.au=Ingkanisorn%2C+W+Patricia%3BPaterson%2C+D+Ian%3BCalvo%2C+Katherine+R%3BRosing%2C+Douglas+R%3BSchwartzentruber%2C+Douglas+J%3BFuisz%2C+Anthon+R%3BArai%2C+Andrew+E&rft.aulast=Ingkanisorn&rft.aufirst=W&rft.date=2006-01-01&rft.volume=8&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+magnetic+resonance+%3A+official+journal+of+the+Society+for+Cardiovascular+Magnetic+Resonance&rft.issn=10976647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of plutonium exposures for an epidemiological study of US nuclear workers. AN - 67914038; 16081492 AB - An ongoing case-control study evaluating the association between workplace external radiation exposures and leukaemia mortality required an assessment of internal plutonium exposures as a potential confounder. Of the study participants, 1,092 were employed at four Department of Energy sites where plutonium-bearing materials were processed or stored. Exposures were assessed by first categorising exposure potentials based on available bioassay data, then estimating doses for workers in the highest categories using recent recommendations of the International Commission on Radiological Protection. Given the aetiology of leukaemia, equivalent dose to active bone marrow was chosen as the exposure variable. There were 556 workers each with at least one plutonium bioassay result, assigned to one of three evaluation categories. Dose estimates were made for 115 workers resulting in a collective equivalent dose of 2.1 person-Sv for 2,822 exposure-years, compared with 29.8 person-Sv estimated from photon exposures. Modelling uncertainties were examined by comparison of results from independent analyses and by Monte Carlo simulation. JF - Radiation protection dosimetry AU - Daniels, R D AU - Lodwick, C J AU - Schubauer-Berigan, M K AU - Spitz, H B AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 5555 Ridge Avenue, R-44 Cincinnati, OH 45213, USA. RTD2@CDC.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 43 EP - 55 VL - 118 IS - 1 SN - 0144-8420, 0144-8420 KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Radiation Protection KW - Epidemiologic Studies KW - Humans KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Monte Carlo Method KW - United States -- epidemiology KW - Risk Assessment KW - Occupational Exposure KW - Radiation Monitoring -- methods KW - Plutonium -- adverse effects KW - Leukemia, Radiation-Induced -- mortality KW - Nuclear Reactors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67914038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Assessment+of+plutonium+exposures+for+an+epidemiological+study+of+US+nuclear+workers.&rft.au=Daniels%2C+R+D%3BLodwick%2C+C+J%3BSchubauer-Berigan%2C+M+K%3BSpitz%2C+H+B&rft.aulast=Daniels&rft.aufirst=R&rft.date=2006-01-01&rft.volume=118&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2006-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antimicrobial resistance and genetic relatedness among Salmonella from retail foods of animal origin: NARMS retail meat surveillance. AN - 67842307; 16602986 AB - Salmonella isolates were recovered from a monthly sampling of chicken breasts, ground turkey, ground beef, and pork chops purchased from selected grocery stores in six participating FoodNet sites (Connecticut, Georgia, Maryland, Minnesota, Oregon, and Tennessee) in 2002 and an additional two sites in 2003 (California and New York). In 2002 and 2003, a total of 6,046 retail meats were examined, including 1,513 chicken breasts, 1,499 ground turkey samples, 1,522 ground beef samples, and 1,502 pork chops. Retail meat samples tested increased to 3,533 in 2003 as compared to 2,513 in 2002. Overall, six percent of 6,046 retail meat samples (n = 365) were contaminated with Salmonella, the bulk recovered from either ground turkey (52%) or chicken breast (39%). Salmonella isolates were serotyped and susceptibility tested using a panel of 16 antimicrobial agents. S. Heidelberg was the predominant serotype identified (23%), followed by S. Saintpaul (12%), S. Typhimurium (11%), and S. Kentucky (10%). Overall, resistance was most often observed to tetracycline (40%), streptomycin (37%), ampicillin (26%), and sulfamethoxazole (25%). Twelve percent of isolates were resistant to cefoxitin and ceftiofur, though only one isolate was resistant to ceftriaxone. All isolates were susceptible to amikacin and ciprofloxacin; however, 3% of isolates were resistant to nalidixic acid and were almost exclusive to ground turkey samples (n = 11/12). All Salmonella isolates were analyzed for genetic relatedness using pulsed-field gel electrophoresis (PFGE) patterns generated by digestion with Xba1 or Xba1 plus Bln1. PFGE fingerprinting profiles showed that Salmonella, in general, were genetically diverse with a total of 175 Xba1 PFGE profiles generated from the 365 isolates. PFGE profiles showed good correlation with serotypes and in some instances, antimicrobial resistance profiles. Results demonstrated a varied spectrum of antimicrobial resistance and PFGE patterns, including several multidrug resistant clonal groups among Salmonella isolates, and signify the importance of sustained surveillance of foodborne pathogens in retail meats. JF - Foodborne pathogens and disease AU - Zhao, S AU - McDermott, P F AU - Friedman, S AU - Abbott, J AU - Ayers, S AU - Glenn, A AU - Hall-Robinson, E AU - Hubert, S K AU - Harbottle, H AU - Walker, R D AU - Chiller, T M AU - White, D G AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, Maryland 20708, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 106 EP - 117 VL - 3 IS - 1 SN - 1535-3141, 1535-3141 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - United States KW - Phylogeny KW - Genetic Variation KW - Animals KW - Food Microbiology KW - Consumer Product Safety KW - Meat Products -- microbiology KW - Humans KW - Electrophoresis, Gel, Pulsed-Field -- methods KW - Drug Resistance, Multiple, Bacterial KW - Microbial Sensitivity Tests KW - Salmonella -- drug effects KW - Salmonella -- genetics KW - Food Contamination -- analysis KW - Drug Resistance, Bacterial -- genetics KW - Anti-Bacterial Agents -- pharmacology KW - Meat -- microbiology KW - Salmonella -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67842307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Antimicrobial+resistance+and+genetic+relatedness+among+Salmonella+from+retail+foods+of+animal+origin%3A+NARMS+retail+meat+surveillance.&rft.au=Zhao%2C+S%3BMcDermott%2C+P+F%3BFriedman%2C+S%3BAbbott%2C+J%3BAyers%2C+S%3BGlenn%2C+A%3BHall-Robinson%2C+E%3BHubert%2C+S+K%3BHarbottle%2C+H%3BWalker%2C+R+D%3BChiller%2C+T+M%3BWhite%2C+D+G&rft.aulast=Zhao&rft.aufirst=S&rft.date=2006-01-01&rft.volume=3&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=15353141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposures and movement abnormalities among Japanese-American men: the Honolulu-Asia Aging Study. AN - 67841324; 16439859 AB - The authors analyzed data on 1,049 men aged 71-93 years (excluding those with prevalent Parkinson's disease and stroke) from the Honolulu Heart Program (1965-1968) and the Honolulu-Asia Aging Study (1991-1999) to determine whether occupational exposures to pesticides, solvents, metals, manganese, and mercury during middle age were associated with 14 movement abnormalities 25 years later. Analyses of variance and multivariate logistic regression were used to assess associations of interest. After adjustment for age, BMI, cognitive functioning, smoking, alcohol drinking, education, and physical activity, there was a positive association between abnormal 'facial expression' and the highest exposure to metals [odds ratio (OR) = 2.62; 95% confidence interval (CI) = 1.35-5.11; trend, p = 0.02], and the highest exposure to mercury (OR = 1.91; 95% CI = 1.04-3.49; trend, p = 0.03). Age was positively associated with all movement abnormalities, and cognitive function, body mass index and physical activity were inversely associated with most movement abnormalities. Higher exposure to any metal, and specifically mercury, was associated with abnormal facial expression. JF - Neuroepidemiology AU - Charles, Luenda E AU - Burchfiel, Cecil M AU - Fekedulegn, Desta AU - Kashon, Michael L AU - Ross, G Webster AU - Petrovitch, Helen AU - Sanderson, Wayne T AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA. lcharles@cdc.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 130 EP - 139 VL - 26 IS - 3 SN - 0251-5350, 0251-5350 KW - Metals KW - 0 KW - Pesticides KW - Solvents KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Hawaii -- epidemiology KW - Cohort Studies KW - Aged KW - Male KW - Prevalence KW - Occupational Diseases -- ethnology KW - Metals -- adverse effects KW - Solvents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Asian Americans KW - Pesticides -- adverse effects KW - Movement Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67841324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroepidemiology&rft.atitle=Occupational+exposures+and+movement+abnormalities+among+Japanese-American+men%3A+the+Honolulu-Asia+Aging+Study.&rft.au=Charles%2C+Luenda+E%3BBurchfiel%2C+Cecil+M%3BFekedulegn%2C+Desta%3BKashon%2C+Michael+L%3BRoss%2C+G+Webster%3BPetrovitch%2C+Helen%3BSanderson%2C+Wayne+T&rft.aulast=Charles&rft.aufirst=Luenda&rft.date=2006-01-01&rft.volume=26&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Neuroepidemiology&rft.issn=02515350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-28 N1 - Date created - 2006-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. AN - 67829670; 16541409 AB - Alternative ionization methods are increasingly being utilized to increase the versatility and selectivity of liquid chromatography/mass spectrometry (LC/MS). One such technique is the practice of using commercially available atmospheric pressure chemical ionization (APCI) sources with the corona discharge turned off, a process termed no-discharge APCI (ND-APCI). The relative LC/MS responses for several different classes of veterinary drugs were obtained by using ND-APCI, electrospray ionization (ESI), and APCI. While the ND-APCI-MS and -MSn spectra for these compounds were comparable with ESI, ND-APCI provided advantages in sensitivity and selectivity for some compounds. Drugs that were charged in solution as cations or sodium adducts responded particularly well with this technique. Instrumental parameters such as temperatures, gas and liquid flow rates, and source design were investigated to determine their effect on the process of ND-APCI. This paper explores advantages of using ND-APCI for the determination and confirmation of drug residues that might be found in food matrices, including malachite green residues in fish tissue and avermectin residues in milk. JF - Rapid communications in mass spectrometry : RCM AU - Turnipseed, Sherri B AU - Andersen, Wendy C AU - Karbiwnyk, Christine M AU - Roybal, José E AU - Miller, Keith E AD - U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225, USA. Sherri.turnipseed@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1231 EP - 1239 VL - 20 IS - 8 SN - 0951-4198, 0951-4198 KW - Antiprotozoal Agents KW - 0 KW - Coloring Agents KW - Indicators and Reagents KW - Rosaniline Dyes KW - Veterinary Drugs KW - malachite green KW - 12058M7ORO KW - Ivermectin KW - 70288-86-7 KW - avermectin KW - 73989-17-0 KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Ivermectin -- analogs & derivatives KW - Ivermectin -- analysis KW - Food Analysis KW - Reference Standards KW - Atmospheric Pressure KW - Meat -- analysis KW - Cattle KW - Fishes KW - Antiprotozoal Agents -- analysis KW - Milk -- chemistry KW - Rosaniline Dyes -- analysis KW - Veterinary Drugs -- analysis KW - Drug Residues -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67829670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=No-discharge+atmospheric+pressure+chemical+ionization%3A+evaluation+and+application+to+the+analysis+of+animal+drug+residues+in+complex+matrices.&rft.au=Turnipseed%2C+Sherri+B%3BAndersen%2C+Wendy+C%3BKarbiwnyk%2C+Christine+M%3BRoybal%2C+Jos%C3%A9+E%3BMiller%2C+Keith+E&rft.aulast=Turnipseed&rft.aufirst=Sherri&rft.date=2006-01-01&rft.volume=20&rft.issue=8&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-06 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. AN - 67769496; 16330873 AB - In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system is also involved in lung fibrogenesis. To study the effect of losartan, an angiotensin II antagonist, on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism. Pulmonary fibrosis was induced in SD rats by intratracheal instillation of bleomycin (5 mg x kg(-1)). Subsequently, the rats received daily losartan (3, 9 and 27 mg x kg(-1)) or prednisone (20 mg x kg(-1)) orally. Six rats in each group were sacrificed 14 and 21 days after intratracheal instillation. Hydroxyproline, superoxide dismutase (SOD), and malondialdehyde (MDA) levels in lung tissues were determined by spectroscopy. The levels of TGF-beta1 in serum were measured by ELISA. Histological changes in the lungs were evaluated by hematoxylin-eosin stain, and scored. Rat body weight evidently decreased while the indices of lung and hydroxyproline contents in lung tissue were significantly increased 14 and 21 days after intratracheal bleomycin instillation. Inflammatory cell infiltration and fibrotic scores were more prominent in the model group compared to the sham group. Losartan (3, 9 and 27 mg.kg(-1), i.g.) apparently attenuated the degree of pulmonary fibrosis. Further study showed that losartan significantly increased SOD levels while it decreased MDA contents in lung homogenates. Serum TGF-beta1 levels of pulmonary fibrosis rats were also decreased by losartan. Losartan had an inhibitory effect on bleomycin-induced pulmonary fibrosis, and its effect may be associated with its anti-free radicals and the reduction in TGF-beta1. JF - Respiration; international review of thoracic diseases AU - Yao, Hong Wei AU - Zhu, Jian Ping AU - Zhao, Meng Hui AU - Lu, Yuan AD - Zhejiang Respiratory Drug Research Laboratory, Food and Drug Administration of China, Zhejiang University School of Medicine, Hangzhou, China. yhgwei@hotmail.com Y1 - 2006 PY - 2006 DA - 2006 SP - 236 EP - 242 VL - 73 IS - 2 SN - 0025-7931, 0025-7931 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Antibiotics, Antineoplastic KW - Glucocorticoids KW - Tgfb1 protein, rat KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Bleomycin KW - 11056-06-7 KW - Malondialdehyde KW - 4Y8F71G49Q KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Losartan KW - JMS50MPO89 KW - Hydroxyproline KW - RMB44WO89X KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Prednisone -- pharmacology KW - Weight Gain -- drug effects KW - Animals KW - Hydroxyproline -- drug effects KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- drug effects KW - Lung -- metabolism KW - Glucocorticoids -- pharmacology KW - Malondialdehyde -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Body Weight -- drug effects KW - Transforming Growth Factor beta -- blood KW - Hydroxyproline -- metabolism KW - Male KW - Bleomycin -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Pulmonary Fibrosis -- drug therapy KW - Pulmonary Fibrosis -- chemically induced KW - Losartan -- pharmacology KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67769496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiration%3B+international+review+of+thoracic+diseases&rft.atitle=Losartan+attenuates+bleomycin-induced+pulmonary+fibrosis+in+rats.&rft.au=Yao%2C+Hong+Wei%3BZhu%2C+Jian+Ping%3BZhao%2C+Meng+Hui%3BLu%2C+Yuan&rft.aulast=Yao&rft.aufirst=Hong&rft.date=2006-01-01&rft.volume=73&rft.issue=2&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Respiration%3B+international+review+of+thoracic+diseases&rft.issn=00257931&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-02 N1 - Date created - 2006-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Malignant mesothelioma mortality in the United States, 1999-2001. AN - 67725860; 16523977 AB - Malignant mesothelioma is strongly associated with asbestos exposure. This paper describes demographic, geographic, and occupational distributions of mesothelioma mortality in the United States, 1999-2001. The data (n = 7,524) were obtained from the National Center for Health Statistics multiple-cause-of-death records. Mortality rates (per million per year) were age-adjusted to the 2000 U.S. standard population, and proportionate mortality ratios (PMRs) were calculated by occupation and industry, and adjusted for age, sex, and race. The overall age-adjusted mortality rate was 11.52, with males (22.34) showing a sixfold higher rate than females (3.94). Geographic distribution of mesothelioma mortality is predominantly coastal. Occupations with significantly elevated PMRs included plumbers/pipefitters and mechanical engineers. Industries with significantly elevated PMRs included ship and boat building and repairing, and industrial and miscellaneous chemicals. These surveillance findings can be useful in generating hypotheses and developing strategies to prevent mesothelioma. JF - International journal of occupational and environmental health AU - Bang, Ki Moon AU - Pinheiro, Germania A AU - Wood, John M AU - Syamlal, Girija AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. PY - 2006 SP - 9 EP - 15 VL - 12 IS - 1 SN - 1077-3525, 1077-3525 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Aged, 80 and over KW - Humans KW - Adult KW - Occupational Diseases -- etiology KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Population Surveillance KW - Occupational Diseases -- mortality KW - Mesothelioma -- epidemiology KW - Mesothelioma -- etiology KW - Mesothelioma -- mortality KW - Occupational Exposure -- adverse effects KW - Asbestos -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67725860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Malignant+mesothelioma+mortality+in+the+United+States%2C+1999-2001.&rft.au=Bang%2C+Ki+Moon%3BPinheiro%2C+Germania+A%3BWood%2C+John+M%3BSyamlal%2C+Girija&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2006-01-01&rft.volume=12&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-05 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of sample preparation and preenrichment media on the recovery of Salmonella from cantaloupes, mangoes, and tomatoes. AN - 67710996; 16512245 AB - Studies were conducted to determine the relative effectiveness of buffered peptone water (BPW), lactose (LAC) broth, and Universal Preenrichment (UP) broth for the recovery of Salmonella organisms from fruit rinses, whole fruit, and comminuted fruit. In the first phase, the relative effectiveness of the rinse and soak methods for the recovery of Salmonella from surface-contaminated mangoes and tomatoes was examined. Fruits were spot inoculated with single Salmonella serovars and held for 4 days at 2-6 degrees C before analysis was initiated. The contaminated fruit was rinsed in portions of BPW, LAC broth, or UP broth. Portions from each rinse were added to its respective broth (e.g., BPW to BPW). Individual whole fruit, in their remaining broth rinses (soak method), and the fruit rinse/broths (rinse method) were incubated for 24 h at 35 degrees C. The Bacteriological Analytical Manual (BAM) Salmonella culture method was followed thereafter. The soak method produced significantly greater numbers (P < 0.05) of positive test portions than did the rinse method for the analysis of mangoes (93 versus 12) and tomatoes (85 versus 34). The 3 broths were comparable for the recovery of Salmonella for both the soak and the rinse methods for mangoes. For tomatoes, there were no significant differences among the broths for the soak method, but BPW and UP broth were significantly more productive (P < 0.05) than LAC broth by the rinse method. In the second phase, the relative effectiveness of LAC broth, BPW, and UP broth for the recovery of Salmonella from comminuted fruit was examined. Fruits were contaminated with single Salmonella serovars and aged for 4 days at 2-6 degrees C. Twenty 25 g test portions were preenriched in each of the following broths: BPW, LAC broth, and UP broth. The BAM Salmonella culture method was followed thereafter. For cantaloupes, significantly more (P < 0.05) Salmonella-positive test portions were recovered with UP broth (96 Salmonella-positive test portions) and BPW (87 Salmonella-positive test portions) than with LAC broth (57 Salmonella-positive test portions). For mangoes, BPW recovered an arithmetically larger number of Salmonella-positive test portions (27 Salmonella-positive test portions) than did either LAC broth (14 Salmonella-positive test portions) or UP broth (18 Salmonella-positive test portions). For tomatoes, there were no significant differences among the broths: BPW recovered 65 Salmonella-positive test portions, UP broth recovered 62 Salmonella-positive test portions, and LAC broth recovered 60 Salmonella-positive test portions. For the analysis of whole fruit, it is recommended that the soak method be used. For whole fruit analyzed with the soak method, UP broth should be used for tomatoes and BPW should be used for mangoes. It is further recommended that UP broth be used for the analysis of comminuted cantaloupes and that BPW be used for the analysis of comminuted mangoes and tomatoes. JF - Journal of AOAC International AU - Hammack, Thomas S AU - Johnson, Mildred L AU - Jacobson, Andrew P AU - Andrews, Wallace H AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Microbiological Studies, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. Thomas.Hammack@fda.hhs.gov PY - 2006 SP - 180 EP - 184 VL - 89 IS - 1 SN - 1060-3271, 1060-3271 KW - Culture Media KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Temperature KW - Food Handling KW - Food Contamination KW - Colony Count, Microbial KW - Bacteriological Techniques KW - Culture Media -- pharmacology KW - Food Microbiology KW - Chemistry Techniques, Analytical -- methods KW - Salmonella -- metabolism KW - Lycopersicon esculentum -- microbiology KW - Mangifera -- microbiology KW - Cucumis melo -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67710996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Educational+Psychology&rft.atitle=The+influence+of+student+learning+characteristics+on+purchase+of+paper+book+and+eBook+for+university+study+and+personal+interest&rft.au=Marie+Johnson%2C+Genevieve&rft.aulast=Marie+Johnson&rft.aufirst=Genevieve&rft.date=2016-10-01&rft.volume=36&rft.issue=9&rft.spage=1551&rft.isbn=&rft.btitle=&rft.title=Educational+Psychology&rft.issn=01443410&rft_id=info:doi/10.1080%2F01443410.2014.1002831 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improved DNA probe detection of Listeria monocytogenes in enrichment culture after physical-chemical fractionation. AN - 67710499; 16512244 AB - Bacterial detection in foods by nucleic acid probes is limited by microflora competition during selective enrichment. Probe target concentration by extraction and fractionation of enrichments may diminish this limitation. The 1-h AccuProbe chemiluminescent culture identification test for Listeria monocytogenes was used as a model. Its high detection threshold provides a stringent challenge for evaluating enrichment work-up protocols. Detection of L. monocytogenes, at 1-4 colony-forming units/g food, was not consistently possible in 48 h enrichment cultures using AccuProbe. Concentration by cell sedimentation was occasionally helpful but the volume of co-sedimented food limited concentration to about 10-fold. To improve concentration, enrichment sediments were sonicated or enzymatically lysed to release the probe's target, r-RNA. The RNA was separated from non-RNA material by extraction with phenol and precipitation with ethanol. Enrichments (250 mL) were concentrated 2500-fold, and the limitation was food RNA volume. A strongly competitive Enterococcus faecium food isolate was used to demonstrate the effect of artificial competition on the kit's ability to detect L. monocytogenes in enrichments. High competitor concentrations repressed the level of the target below the detection threshold, but concentration of r-RNA enabled detection of L. monocytogenes. The effectiveness of this enrichment sample work-up was demonstrated with naturally contaminated hummus. JF - Journal of AOAC International AU - Duvall, Robert E AU - Eklund, Marjut AU - Tran, Tony T AU - Hitchins, Anthony D AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-5 16, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA. PY - 2006 SP - 172 EP - 179 VL - 89 IS - 1 SN - 1060-3271, 1060-3271 KW - Culture Media KW - 0 KW - DNA Probes KW - Phenol KW - 339NCG44TV KW - Ethanol KW - 3K9958V90M KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Phenol -- chemistry KW - Food Microbiology KW - Enterococcus faecium -- metabolism KW - Food Analysis KW - Binding, Competitive KW - Temperature KW - Colony Count, Microbial KW - RNA -- chemistry KW - RNA -- analysis KW - Ethanol -- chemistry KW - Stem Cells KW - Bacteriological Techniques KW - Time Factors KW - Listeria monocytogenes -- metabolism KW - DNA Probes -- chemistry KW - Chemistry Techniques, Analytical -- methods KW - DNA Probes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67710499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Improved+DNA+probe+detection+of+Listeria+monocytogenes+in+enrichment+culture+after+physical-chemical+fractionation.&rft.au=Duvall%2C+Robert+E%3BEklund%2C+Marjut%3BTran%2C+Tony+T%3BHitchins%2C+Anthony+D&rft.aulast=Duvall&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=89&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Mycotoxins. AN - 67709574; 16512257 JF - Journal of AOAC International AU - Trucksess, Mary W AU - Committee on Natural Toxins and Food Allergens Y1 - 2006 PY - 2006 DA - 2006 SP - 270 EP - 284 VL - 89 IS - 1 KW - Aflatoxins KW - 0 KW - Mycotoxins KW - Toxins, Biological KW - Index Medicus KW - Food Analysis -- methods KW - Food Contamination KW - Mass Spectrometry -- methods KW - Calibration KW - Aflatoxins -- chemistry KW - Chemistry Techniques, Analytical -- methods KW - Mycotoxins -- chemistry KW - Mycotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67709574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Mycotoxins.&rft.au=Trucksess%2C+Mary+W%3BCommittee+on+Natural+Toxins+and+Food+Allergens&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2006-01-01&rft.volume=89&rft.issue=1&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Food microbiology, nondairy. AN - 67709111; 16512262 JF - Journal of AOAC International AU - Andrews, Wallace H AU - Hammack, Thomas S AU - Committee on Residues and Related Topics Y1 - 2006 PY - 2006 DA - 2006 SP - 304 EP - 318 VL - 89 IS - 1 KW - Culture Media KW - 0 KW - Index Medicus KW - Escherichia coli -- metabolism KW - Reproducibility of Results KW - Meat Products -- microbiology KW - Food Analysis KW - Food Contamination KW - Salmonella -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Culture Media -- metabolism KW - Food Microbiology KW - Chemistry Techniques, Analytical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67709111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Food+microbiology%2C+nondairy.&rft.au=Andrews%2C+Wallace+H%3BHammack%2C+Thomas+S%3BCommittee+on+Residues+and+Related+Topics&rft.aulast=Andrews&rft.aufirst=Wallace&rft.date=2006-01-01&rft.volume=89&rft.issue=1&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liquid chromatographic determination of N-methyl carbamate pesticide residues at low parts-per-billion levels in eggs. AN - 67709019; 16512248 AB - A reversed-phase liquid chromatographic (LC) method is presented for the analysis of N-methyl carbamate pesticide residues and piperonyl butoxide in eggs at levels as low as 2 microg/kg (ppb). The study was undertaken to provide data for dietary exposure estimates used in risk analysis. The method uses an acetonitrile extraction followed by liquid-liquid partitioning and normal-phase aminopropyl solid-phase extraction column cleanup. Determination of residues is by reversed-phase LC with an inline postcolumn reaction followed by fluorescence detection. The average recoveries of 21 fortified (most at 2.0 and 20.0 ppb) N-methyl carbamate pesticide residues and the carbamate metabolite 1-naphthol from eggs ranged from 70 to 107%. Recoveries of the pesticide synergist piperonyl butoxide ranged from 63 to 106%. Single-comb White Leghorn hens were treated with the carbamate carbaryl, and the eggs subsequently produced were analyzed for carbaryl and 1-naphthol residues. JF - Journal of AOAC International AU - Schenck, Frank J AU - Podhorniak, Lynda V AU - Hobbs, James AU - Casanova, John AU - Donoghue, Dan AD - U.S. Food and Drug Administration, Southeastern Regional Laboratory, Atlanta, GA 30309, USA. fschenck@ora.fda.gov PY - 2006 SP - 196 EP - 200 VL - 89 IS - 1 SN - 1060-3271, 1060-3271 KW - Carbamates KW - 0 KW - Naphthols KW - Pesticide Residues KW - Pesticides KW - Gelatin KW - 9000-70-8 KW - methyl carbamate KW - 9WFX634X2T KW - Index Medicus KW - Naphthols -- analysis KW - Risk KW - Gelatin -- chemistry KW - Animals KW - Chickens KW - Time Factors KW - Food Analysis -- methods KW - Chromatography, Liquid -- methods KW - Carbamates -- analysis KW - Chemistry Techniques, Analytical -- methods KW - Eggs -- analysis KW - Pesticide Residues -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67709019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Liquid+chromatographic+determination+of+N-methyl+carbamate+pesticide+residues+at+low+parts-per-billion+levels+in+eggs.&rft.au=Schenck%2C+Frank+J%3BPodhorniak%2C+Lynda+V%3BHobbs%2C+James%3BCasanova%2C+John%3BDonoghue%2C+Dan&rft.aulast=Schenck&rft.aufirst=Frank&rft.date=2006-01-01&rft.volume=89&rft.issue=1&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Marine and freshwater toxins. AN - 67708543; 16512256 AB - In a very busy and exciting year, 2005 included First Action approval of a much needed official method for paralytic shellfish toxins and multiple international toxin symposia highlighted by groundbreaking research. These are the first-year milestones and activities of the Marine and Freshwater Toxins Task Force and Analytical Community. Inaugurated in 2004 and described in detail in last year's General Referee Report (1) this international toxins group has grown to 150 members from many regions and countries. Perhaps most important they are now making important and global contributions to food safety and to providing alternatives to animal-based assays. Official Method 2005.06 was first approved in late 2004 by the Task Force and subsequently Official First Action in 2005 (2) by the Methods Committee on Natural Toxins and Food Allergens and the Official Methods Board. This nonproprietary method (3) is a precolumn oxidation, liquid chromatographic method that makes good use of fluorescence detection to provide high sensitivity detection of the saxitoxins. It has also proven to be rugged enough for regulatory use and the highest level of validation. As pointed out in the report of method principle investigator and Study Director James Lawrence, approval of 2005.06 now provides the first official alternative to the mouse bioassay after many decades of shellfish monitoring. This past year in April 2005 the group also held their first international conference, "Marine and Freshwater Toxins Analysis: Ist Joint Symposium and AOAC Task Force Meeting," in Baiona, Spain. The 4-day conference consisted of research and stakeholder presentations and symposium-integrated subgroup sessions on ciguatoxins, saxitoxin assays and liquid chromatography (LC) methods for saxitoxins and domoic acids, okadaiates and azaspiracids, and yessotoxins. Many of these subgroups were recently formed in 2005 and are working towards their goals of producing officially validated analytical methods. (Abstracts from the Baiona 2005 meeting cited in this report can be found in the online version of the conference abstract book in the Files and Folders section of the Marine and Freshwater Toxins online community at www.aoac.org.) An active topic for discussion in Baiona and subsequent Task Force activities was the expert consultation for Codex which met in Oslo, Norway in 2004 (previously described and cited in last year's GR report, ref 1). The consultation group's executive summary report (http://www.fao.org/es/ESN/food/risk_biotoxin en.stm) describes suggested changes in action levels as well as methods, method validation, and other issues. September 2005 saw the AOAC Task Force efforts further supported by another symposium, "Marine and Freshwater Toxins: Quality Methods for Food Safety and International Trade," at the AOAC INTERNATIONAL Annual Conference in Orlando, Florida. The multidisciplinary talks at this full day symposium ranged from ciguatoxins to cyanobacterial toxins, and spanned toxicology, biochemistry, molecular biology and analytical chemistry. Again, the symposium preceded Task Force meetings. Toxin subgroups, including a new group on cyanobacterial toxins, met for engaging and productive subgroup discussions. All of these activities were preceded by a Wiley Award symposium for Task Force member Mike Quilliam of NRC Canada. These talks, presented at a half-day symposium on the first day of the Annual Meeting, focused on Quilliam's work with LC tandem mass spectrometry (LC/MS/MS) and certified reference standards and materials, and included related presentations by some of his many research collaborators. To maintain flow and continuity between symposia and between Task Force meetings, the group now uses new electronic discussion forums. Individual subgroup areas, under the Marine and Freshwater Toxins Task Force, comprise this online community. First introduced by AOAC INTERNATIONAL in early 2005, these new resources are being used to distribute information and to supplement the in-person subgroup meetings and electronic mail in the group's validation efforts. JF - Journal of AOAC International AU - Hungerford, James M AU - Committee on Natural Toxins and Food Allergens Y1 - 2006 PY - 2006 DA - 2006 SP - 248 EP - 269 VL - 89 IS - 1 KW - Toxins, Biological KW - 0 KW - Saxitoxin KW - 35523-89-8 KW - Index Medicus KW - Tetraodontiformes KW - Animals KW - Chromatography, Liquid -- methods KW - Reproducibility of Results KW - Saxitoxin -- analysis KW - Fresh Water KW - Food Analysis KW - Biological Assay KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Toxins, Biological -- analysis KW - Chemistry Techniques, Analytical -- methods KW - Shellfish -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67708543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Marine+and+freshwater+toxins.&rft.au=Hungerford%2C+James+M%3BCommittee+on+Natural+Toxins+and+Food+Allergens&rft.aulast=Hungerford&rft.aufirst=James&rft.date=2006-01-01&rft.volume=89&rft.issue=1&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Errors associated with three methods of assessing respirator fit. AN - 67663080; 16485349 AB - Three fit test methods (Bitrex, saccharin, and TSI PortaCount Plus with the N95-Companion) were evaluated for their ability to identify wearers of respirators that do not provide adequate protection during a simulated workplace test. Thirty models of NIOSH-certified N95 half-facepiece respirators (15 filtering-facepiece models and 15 elastomeric models) were tested by a panel of 25 subjects using each of the three fit testing methods. Fit testing results were compared to 5th percentiles of simulated workplace protection factors. Alpha errors (the chance of failing a fit test in error) for all 30 respirators were 71% for the Bitrex method, 68% for the saccharin method, and 40% for the Companion method. Beta errors (the chance of passing a fit test in error) for all 30 respirator models combined were 8% for the Bitrex method, 8% for the saccharin method, and 9% for the Companion method. The three fit test methods had different error rates when assessed with filtering facepieces and when assessed with elastomeric respirators. For example, beta errors for the three fit test methods assessed with the 15 filtering facepiece respirators were < or = 5% but ranged from 14% to 21% when assessed with the 15 elastomeric respirators. To predict what happens in a realistic fit testing program, the data were also used to estimate the alpha and beta errors for a simulated respiratory protection program in which a wearer is given up to three trials with one respirator model to pass a fit test before moving onto another model. A subject passing with any of the three methods was considered to have passed the fit test program. The alpha and beta errors for the fit testing in this simulated respiratory protection program were 29% and 19%, respectively. Thus, it is estimated, under the conditions of the simulation, that roughly one in three respirator wearers receiving the expected reduction in exposure (with a particular model) will fail to pass (with that particular model), and that roughly one in five wearers receiving less reduction in exposure than expected will pass the fit testing program in error. JF - Journal of occupational and environmental hygiene AU - Coffey, Christopher C AU - Lawrence, Robert B AU - Zhuang, Ziqing AU - Duling, Matthew G AU - Campbell, Donald L AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia, USA. ccoffey@cdc.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 44 EP - 52 VL - 3 IS - 1 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Occupational Exposure -- prevention & control KW - Equipment Failure Analysis KW - Humans KW - Adult KW - Middle Aged KW - Research Design KW - National Institute for Occupational Safety and Health (U.S.) KW - Male KW - Female KW - Materials Testing KW - Respiratory Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67663080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Errors+associated+with+three+methods+of+assessing+respirator+fit.&rft.au=Coffey%2C+Christopher+C%3BLawrence%2C+Robert+B%3BZhuang%2C+Ziqing%3BDuling%2C+Matthew+G%3BCampbell%2C+Donald+L&rft.aulast=Coffey&rft.aufirst=Christopher&rft.date=2006-01-01&rft.volume=3&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-16 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency. AN - 67650916; 16314341 AB - DNA mismatch repair (MMR) deficiencies result in increased frequencies of spontaneous mutation and tumor formation. In the present study, we tested the hypothesis that a chemically-induced mutational response would be greater in a mouse with an MMR-deficiency than in the MMR-proficient mouse models commonly used to assay for chemical carcinogenicity. To accomplish this, the induction of H-ras codon 61 CAA-->AAA mutation was examined in Pms2 knockout mice (Pms2-/-, C57BL/6 background) and sibling wild-type mice (Pms2+/+). Groups of five or six neonatal male mice were treated with 0.3 micromol 4-aminobiphenyl (4-ABP) or the vehicle control, dimethylsulfoxide. Eight months after treatment, liver DNAs were isolated and analysed for levels of H-ras codon 61 CAA-->AAA mutation using allele-specific competitive blocker-PCR. In Pms2-proficient and Pms2-deficient mice, 4-ABP treatment caused an increase in mutant fraction (MF) from 1.65x10(-5) to 2.91x10(-5) and from 3.40x10(-5) to 4.70x10(-5), respectively. Pooling data from 4-ABP-treated and control mice, the approximately 2-fold increase in MF observed in Pms2-deficient as compared with Pms2-proficient mice was statistically significant (P=0.0207) and consistent with what has been reported previously in terms of induction of G:C-->T:A mutation in a Pms2-deficient background. Pooling data from both genotypes, the increase in H-ras MF in 4-ABP-treated mice, as compared with control mice, did not reach the 95% confidence level of statistical significance (P=0.0606). The 4-ABP treatment caused a 1.76-fold and 1.38-fold increase in average H-ras MF in Pms2-proficient and Pms2-deficient mice, respectively. Furthermore, the levels of induced mutation in Pms2-proficient and Pms2-deficient mice were nearly identical (1.26x10(-5) and 1.30x10(-5), respectively). We conclude that Pms2-deficiency does not result in an amplification of the H-ras codon 61 CAA-->AAA mutational response induced by 4-ABP. JF - Mutagenesis AU - Parsons, Barbara L AU - Delongchamp, Robert R AU - Beland, Frederick A AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, Division of Biometry and Risk Assessment and Division of Biochemical Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA. bparsons@nctr.fda.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 29 EP - 34 VL - 21 IS - 1 SN - 0267-8357, 0267-8357 KW - Aminobiphenyl Compounds KW - 0 KW - Carcinogens KW - Codon KW - DNA-Binding Proteins KW - 4-biphenylamine KW - 16054949HJ KW - DNA KW - 9007-49-2 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Pms2 protein, mouse KW - Mismatch Repair Endonuclease PMS2 KW - EC 3.6.1.3 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Animals, Newborn KW - Animals KW - Liver -- drug effects KW - DNA -- metabolism KW - DNA -- genetics KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Female KW - Mice, Knockout KW - Carcinogens -- pharmacology KW - Genes, ras -- genetics KW - Codon -- genetics KW - DNA Repair Enzymes -- genetics KW - Adenosine Triphosphatases -- physiology KW - Point Mutation KW - DNA-Binding Proteins -- genetics KW - Aminobiphenyl Compounds -- pharmacology KW - DNA-Binding Proteins -- physiology KW - DNA Repair Enzymes -- physiology KW - Adenosine Triphosphatases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67650916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Levels+of+H-ras+codon+61+CAA+to+AAA+mutation%3A+response+to+4-ABP-treatment+and+Pms2-deficiency.&rft.au=Parsons%2C+Barbara+L%3BDelongchamp%2C+Robert+R%3BBeland%2C+Frederick+A%3BHeflich%2C+Robert+H&rft.aulast=Parsons&rft.aufirst=Barbara&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of X-ray fluorescence and wet chemical analysis for lead on air filters from different personal samplers used in a secondary lead smelter/solder manufacturer. AN - 67607659; 16395471 AB - Portable X-ray fluorescence (XRF) technology may provide faster turn-around without compromising accuracy when assessing personal exposures to metals such as lead, but it has only been tested in limited field environments. This study is part of a series, where various types of sampler are used to collect airborne lead in different environments for presentation to a portable XRF analyzer. In this case personal samples were taken at a manufacturer of solder alloys consisting mainly of lead and tin, using the closed-face 37 mm cassette (CFC), the 37 mm GSP or "cone" sampler, the 25 mm Institute of Occupational Medicine (IOM) inhalable sampler, the 25 mm button sampler, and the open-face 25 mm cassette. Mixed cellulose-ester filters were used in all samplers. Following XRF analysis the samples were extracted with acid and analyzed by inductively coupled plasma optical emission spectroscopy (ICP). The internal surfaces of CFC's and 25 mm open-face cassettes were also wiped, and the wipes analyzed for lead to assess wall-losses in these two samplers. Analysis of all elements present is useful to ascertain contributions to matrix interference effects. In addition to lead, other metals such as tin, copper, iron, silver, cadmium and antimony were also detected in some or all of the samples by ICP analysis, but only copper and iron could be determined using the XRF analyzer under test. After the removal of a few outliers, all five samplers gave good correlations (r(2) > 0.9) between the two analytical methods over the entire range of found lead mass, which encompassed both the action level and the permissible exposure limit enforced in the USA by the Occupational Safety and Health Administration (OSHA). Linear regression on the results from most samplers gave almost 1 ratio 1 correlations without additional correction, indicating an absence of matrix effects, particularly from tin, which was the most common element after lead. The average of three XRF readings across filters from the GSP samplers gave the best results with 96.7% of results within +/-25% and 100% within +/-30% of the associated ICP values. Using the center reading only was almost as good with 90.0% of results within +/-25% and 96.7% within +/-30% of the associated ICP values, and results can be obtained faster with a single reading. The use of an algorithm developed by OSHA for three readings from the CFC filter samples gave the next best results with 93.3% of XRF results within +/-25% of the corresponding ICP values. However, analysis of wipes from the interior of the cassettes indicated a substantial loss of sample to the walls, and even larger wall-losses were encountered in the 25 mm open-face cassette. Neither this latter sampler nor the IOM or button sampler met the 95% criterion, even for +/-30% accuracy. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Pacolay, Bruce AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 140 EP - 146 VL - 8 IS - 1 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - X-Rays KW - Filtration KW - Fluorescence KW - Inhalation Exposure -- analysis KW - Humans KW - Spectrophotometry, Atomic KW - Metallurgy KW - Air Pollutants, Occupational -- analysis KW - Lead -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67607659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=A+comparison+of+X-ray+fluorescence+and+wet+chemical+analysis+for+lead+on+air+filters+from+different+personal+samplers+used+in+a+secondary+lead+smelter%2Fsolder+manufacturer.&rft.au=Harper%2C+Martin%3BPacolay%2C+Bruce&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2006-01-01&rft.volume=8&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Airborne endotoxin in woodworking (joinery) shops. AN - 67607232; 16395462 AB - Symptoms such as shortness of breath and cough have been noted in woodworking facilities even where wood dust itself is well-controlled. Suspicion has fallen on other possible contaminants in the workplace atmosphere, including bacterial endotoxin. A few studies have indicated potentially high endotoxin exposure with exposure to fresh wood in sawmills and in the production of fiberboard and chipboard, but fewer studies have been carried out on exposure to endotoxin in dry wood work, for example in joineries. A study of the endotoxin content of airborne wood dust samples from US woodworking facilities is presented, from the re-analysis of samples which previously had been taken to establish mass collection relationships between the IOM sampler, the closed-face 37 mm plastic cassette (CFC) sampler and the Button sampler. Endotoxin was strongly correlated with total dust, but the endotoxin content of a few fresh wood samples was found to be up to ten times higher per unit of wood dust than for dried-wood samples, and this difference was significant. No long-term time-weighted average sample exceeded the recommended limit value of 50 EU m(-3) (EU, endotoxin units)used in the Netherlands, although a number of the IOM samples came close (seven samples or 44% exceeded 20 EU m(-3)) and one short-term (48 minute) sample registered a high value of 73 EU m(-3). The geometric mean concentration from the IOM samples (11 EU m(-3)) is within the range of geometric means found from Australian joineries (3.7-60, combined: 24 EU m(-3)). In contrast, the corresponding values from the CFC (3.6 EU m(-3)), and the Button sampler (2.1 EU m(-3)) were much lower and no samples exceeded 20 EU m(-3). Endotoxin is likely only to be a significant problem in working with dried woods when associated with very high dust levels, where the wood dust itself is likely to be a cause for concern. The results from the few samples in this study where fresh wood was being worked were similar to results from other studies involving fresh woods. The agreement between these studies is encouraging given the difficulties of endotoxin analysis and the wide variation often expected between different laboratories. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 73 EP - 78 VL - 8 IS - 1 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Endotoxins KW - Index Medicus KW - Environmental Monitoring KW - Inhalation Exposure -- analysis KW - Dust -- analysis KW - Humans KW - Air Pollutants, Occupational -- analysis KW - Wood KW - Endotoxins -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67607232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Airborne+endotoxin+in+woodworking+%28joinery%29+shops.&rft.au=Harper%2C+Martin%3BAndrew%2C+Michael+E&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2006-01-01&rft.volume=8&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a standardized method for determining soluble silver in workplace air samples. AN - 67606904; 16395470 AB - Several occupational exposure limits and guidelines exist for silver, but the values for each depend on the chemical form of the silver compound in question. In the past, it generally was not possible, without prior knowledge of the work process, to distinguish soluble silver from insoluble silver compounds collected in workplace air samples. Therefore, analytical results were historically reported as total silver. In this study, work was conducted to evaluate a method to differentiate between the quantities of water-soluble silver compounds and total silver collected on filters. The investigation entailed an evaluation of an International Organization for Standardization method to determine soluble silver in airborne particulate matter. The study design incorporated laboratory experiments to evaluate analytical figures of merit, such as selection of appropriate filter media and extraction solution, analytical recovery, and sample stability during storage. Polytetrafluoroethylene (PTFE) filters (2 microm, 37 mm) in opaque cassettes were either spiked with known amounts of silver nitrate or contained a known mass of solid silver nitrate. Results showed that over 90% of the silver was recovered from PTFE filters. Also, field studies were conducted in which workplace air samples were collected in two silver refineries. Some of these samples were analyzed only for soluble silver while others were sequentially extracted and analyzed, first, for soluble silver, then for total silver. The mass fractions of soluble silver, as compared to total silver, were approximately 2% or less. This investigation served to validate an international standard procedure for the determination of soluble silver in workplace air samples. JF - Journal of environmental monitoring : JEM AU - Drake, Pamela L AU - Dale Marcy, A AU - Ashley, Kevin AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave., Spokane, WA 99207, USA. pdrake@cdc.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 134 EP - 139 VL - 8 IS - 1 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Silver KW - 3M4G523W1G KW - Polytetrafluoroethylene KW - 9002-84-0 KW - Index Medicus KW - Occupational Exposure KW - Evaluation Studies as Topic KW - Filtration KW - Workplace KW - Metallurgy KW - Silver -- analysis KW - Air Pollutants, Occupational -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67606904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Evaluation+of+a+standardized+method+for+determining+soluble+silver+in+workplace+air+samples.&rft.au=Drake%2C+Pamela+L%3BDale+Marcy%2C+A%3BAshley%2C+Kevin&rft.aulast=Drake&rft.aufirst=Pamela&rft.date=2006-01-01&rft.volume=8&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic and functional analyses of the lgtH gene, a member of the beta-1,4-galactosyltransferase gene family in the genus Neisseria. AN - 67600260; 16385122 AB - Lipooligosaccharide (LOS) is a major virulence factor of the pathogenic Neisseria. Three galactosyltransferase genes, lgtB, lgtE and lgtH, responsible for the biosynthesis of LOS oligosaccharide chains, were analysed in five Neisseria species. The function of lgtH in Neisseria meningitidis 6,275 was determined by mutagenesis and chemical characterization of the parent and mutant LOS chains. The chemical characterization included SDS-PAGE, immunoblot, hexose and mass spectrometry analyses. Compared with the parent LOS, the mutant LOS lacked galactose, and its oligosaccharide decreased by three or four sugar units in matrix-assisted laser desorption ionization (MALDI)-MS analysis. The results show that lgtH encodes a beta-1,4-galactosyltransferase, and that the glucose moiety linked to heptose (Hep) in the alpha chain is the acceptor site in the biosynthesis of Neisseria LOS. To understand the sequence diversity and relationships of lgtB, lgtE and lgtH, the entire lgt-1 locus was further sequenced in three N. meningitidis strains and three commensal Neisseria strains, and compared with the previously reported lgt genes from Neisseria species. Comparison of the protein sequences of the three enzymes LgtB, LgtE and LgtH showed a conserved N-terminal region, and a highly variable C-terminal region, suggesting functional constraint for substrate and acceptor specificity, respectively. The analyses of allelic variation and evolution of 23 lgtB, 12 lgtE and 14 lgtH sequences revealed a distinct evolutionary history of these genes in Neisseria. For example, the splits graph of lgtE displayed a network evolution, indicating frequent DNA recombination, whereas splits graphs of lgtB and lgtH displayed star-tree-like evolution, indicating the accumulation of point mutations. The data presented here represent examples of the evolution and variation of prokaryotic glycosyltransferase gene families. These imply the existence of multiple enzyme isoforms for biosynthesis of a great diversity of oligosaccharides in nature. JF - Microbiology (Reading, England) AU - Zhu, Peixuan AU - Boykins, Robert A AU - Tsai, Chao-Ming AD - Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA. pzhu@creatvmicrotech.com Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 123 EP - 134 VL - 152 SN - 1350-0872, 1350-0872 KW - Bacterial Proteins KW - 0 KW - Lipopolysaccharides KW - lipid-linked oligosaccharides KW - N-Acetyllactosamine Synthase KW - EC 2.4.1.90 KW - Index Medicus KW - Genetic Variation KW - Alleles KW - Sequence Alignment KW - Neisseria meningitidis -- metabolism KW - Molecular Sequence Data KW - Lipopolysaccharides -- biosynthesis KW - Neisseria meningitidis -- genetics KW - Amino Acid Sequence KW - Evolution, Molecular KW - N-Acetyllactosamine Synthase -- genetics KW - Genes, Bacterial KW - Bacterial Proteins -- genetics KW - Neisseria -- genetics KW - Bacterial Proteins -- metabolism KW - N-Acetyllactosamine Synthase -- metabolism KW - Neisseria -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67600260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Genetic+and+functional+analyses+of+the+lgtH+gene%2C+a+member+of+the+beta-1%2C4-galactosyltransferase+gene+family+in+the+genus+Neisseria.&rft.au=Zhu%2C+Peixuan%3BBoykins%2C+Robert+A%3BTsai%2C+Chao-Ming&rft.aulast=Zhu&rft.aufirst=Peixuan&rft.date=2006-01-01&rft.volume=152&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-17 N1 - Date created - 2005-12-30 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AY869718; GENBANK; AY134878; AY869717; AY134877; AY134876 N1 - Last updated - 2017-01-18 ER - TY - GEN T1 - Tribal Child Care Facilities: A Guide to Construction and Renovation AN - 62014650; ED498553 AB - The Personal Responsibility and Work Opportunity Reconciliation Act of 1996 allowed Tribes to use Child Care and Development Fund (CCDF) monies for the construction or renovation of child care facilities. As procedures have been implemented over the years, Tribes and Administration for Children and Families (ACF) Regional Offices have identified a number of issues and needs. Construction and renovation is a new area for many tribal child care programs. This guide is designed to provide technical assistance to address major areas of the process, including: (1) Conducting a child care community needs assessment; (2) Identifying a site for the facility; (3) Financing the construction and renovation costs; (4) Developing a business plan for the facility; (5) Conducting an environmental assessment; (6) Building a facility; (7) Designing and planning for the facility; (8) Hiring a contractor; and (9) Overseeing the project. The guide also includes a glossary and resource list. The following are appended: (1) CCDF Program Instruction (ACYF-PI-CC-04-01), dated January 23, 2004; (2) CCDF Policy Interpretation Question (ACYF-PIQ-CC-99-01), dated February 24, 1999; (3) Sample Notice of Federal Interest; (4) Application of Title III (Public Accommodations) of the Americans with Disabilities Act (ADA) to the Tribes; (5) U.S. Department of Housing and Urban Development Indian Housing Area Office of Native American Programs (ONAP) Directory; (6) Tribal Child Care Technical Assistance Center Fact Sheet; (7) National Child Care Information Center Fact Sheet; (8) Child Care Bureau Staff List; (9) ACF Regional Office Tribal Lead Contacts List; and (10) National Head Start Facilities Assistance Desk Fact Sheet. [This report was prepared for Special Tribal Cluster Training, Construction and Renovation of Child Care Facilities (Oklahoma City, Oklahoma, February 28-March 1, 2006).] Y1 - 2006 PY - 2006 DA - 2006 SP - 87 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Americans with Disabilities Act 1990 KW - Personal Responsibility and Work Opp Recon Act KW - ERIC, Resources in Education (RIE) KW - Site Selection KW - Information Sources KW - Facilities Management KW - Site Development KW - Child Care KW - Needs Assessment KW - Community Needs KW - American Indians KW - Tribes KW - Facility Planning KW - Construction Management KW - Environmental Influences KW - Social Services KW - Disadvantaged Youth KW - Facility Improvement KW - Technical Assistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62014650?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Monitoring the Future: National Survey Results on Drug Use, 1975-2005. Volume II: College Students and Adults Ages 19-45, 2005 AN - 62006912; ED494061 AB - This volume--the second in a two-volume set from the Monitoring the Future study--provides findings on the substance use and related behaviors of several segments of the adult population. It also contains findings on attitudes and beliefs about drugs, as well as on several particularly salient dimensions of their social environments. Volume I presents similar findings for American secondary school students in grades 8, 10, and 12. One important segment covered here is the population of American college students; a second is their age peers who are not attending college. Also covered in this volume are young adult high school graduates ages 19 to 30 (including the college students), as well as high school graduates at ages 35, 40, and 45. Monitoring the Future is a long-term research program conducted at the University of Michigan's Institute for Social Research under a series of investigator-initiated research grants from the National Institute on Drug Abuse. Now in its 31st year, it comprises, in part, ongoing series of annual nationally representative surveys of 12th-grade students (begun in 1975) and of 8th- and 10th-grade students (begun in 1991). (Contains 40 tables and 58 figures.) [For Volume I, see ED494056.] AU - Johnston, Lloyd D. AU - O'Malley, Patrick M. AU - Bachman, Jerald G. AU - Schulenberg, John E. Y1 - 2006 PY - 2006 DA - 2006 SP - 321 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Norms KW - Drinking KW - At Risk Persons KW - Communicable Diseases KW - High School Graduates KW - Substance Abuse KW - Gender Differences KW - Grants KW - Young Adults KW - Racial Differences KW - National Surveys KW - Adults KW - Demography KW - Smoking KW - Alcohol Abuse KW - Social Attitudes KW - Peer Influence KW - Sexually Transmitted Diseases KW - College Students KW - Age Differences KW - Adolescents KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62006912?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Monitoring the Future: National Survey Results on Drug Use, 1975-2005. Volume I. Secondary School Students AN - 62003026; ED494056 AB - In 2005, the Monitoring the Future study marked its 31st year of conducting national surveys of substance use among American young people. Beginning with the first survey of high school seniors in 1975, the study has provided the nation with a window through which to view the important, but largely hidden, problem behaviors of illicit drug use, alcohol use, and cigarette smoking. It has thus enabled the nation to gain a better understanding of the changing nature of these problems, as well as some of their causes and consequences. This annual monograph series has been the primary vehicle for disseminating the epidemiological findings from the study. It has grown substantially over the years in both coverage and size, in part because of the proliferation of substances being used. This latest two-volume monograph presents the results of the 31st (2005) national survey of drug use and related attitudes and beliefs among American high school seniors, the 26th such survey of American college students, and the 15th such survey of 8th- and 10th-grade students. Results have also been reported for varying intervals on young adult high school graduates, as well as adult high school graduates into middle age (currently through age 45) who have been followed from high school graduation through a series of panel studies. Appended are: (1) Prevalence and Trend Estimates Adjusted for Absentees and Dropouts; (2) Definition of Background and Demographic Subgroups; (3) Estimation of Sampling Errors; (4) Trends by Subgroup: Supplemental Tables for Secondary School Students; and (5) Trends in Specific Subclasses of Hallucinogens, Amphetamines, Tranquilizers, and Narcotic Drugs Other Than Heroin. (Contains 173 tables and 68 figures.) AU - Johnston, Lloyd D. AU - O'Malley, Patrick M. AU - Bachman, Jerald G. AU - Schulenberg, John E. Y1 - 2006 PY - 2006 DA - 2006 SP - 715 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Secondary Education KW - High School Graduates KW - Young Adults KW - Secondary School Students KW - National Surveys KW - Dropouts KW - Smoking KW - Student Attitudes KW - High Schools KW - College Students KW - Intervals KW - Drug Use KW - Trend Analysis KW - Futures (of Society) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/62003026?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Case Studies of Federal Occupational Health's EAP Responses to Natural Disasters AN - 61418613; 200801107 AB - SUMMARY. Employee assistance professionals have increasingly been called upon to address the emotional and mental health needs of customer organizations and their employees in response to large-scale natural or man-made disasters. In doing so, employee assistance program (EAP) professionals must use a repertoire of responses that encompasses a broad range of interventions, generally anchored in an understanding of and focus on the organization and its culture, mission, management and labor concerns, and other critical characteristics. The EAP's fall-back response to a crisis affecting the workplace is often a critical incident stress debriefing or close variant of it. However, EAPs can best serve their customers at all levels with interventions attuned to an understanding of the workplace culture gained through a consultative relationship with management, while factoring in the nature of the disaster, the length of time and characteristics of the disaster's aftermath, and the nuances of the employees' physical and emotional needs throughout the, entire disaster response and recovery process. This article highlights these issues through the presentation of two case studies, gained from the hurricane response activities of the Federal Occupational Health (FOH) EAP. FOH, a service unit within the U.S. Department of Health and Human Services' Program Support Center, has 60 years of experience working in partnership with its federal agency customers to deliver comprehensive occupational health services to improve the health, safety, and productivity of the federal workforce. FOH's EAP contracts with vendor organizations to provide direct employee assistance, work/life, and related services to more than 1.3 million federal employees. The first case study describes (from the first person perspective) an on-site, multi-focused EAP intervention at a federal facility. The second case study describes management consultation with the U.S. Postal Service in response to major hurricane activity. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Workplace Behavioral Health AU - Stephenson, Diane AU - Schneider, Dorothea U AD - Federal Occupational Health, Program Support Center, U.S. Department of Health and Human Services E-mail: DStephenson@psc.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 35 EP - 58 PB - The Haworth Press, Binghamton NY VL - 21 IS - 3-4 SN - 1555-5240, 1555-5240 KW - Crisis management, disaster response, deployment, EAP, natural disasters KW - Human Services KW - Management KW - Natural Disasters KW - Employee Assistance Programs KW - Workplaces KW - Health Care Services KW - article KW - 6145: education, work, & occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61418613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Workplace+Behavioral+Health&rft.atitle=Case+Studies+of+Federal+Occupational+Health%27s+EAP+Responses+to+Natural+Disasters&rft.au=Stephenson%2C+Diane%3BSchneider%2C+Dorothea+U&rft.aulast=Stephenson&rft.aufirst=Diane&rft.date=2006-01-01&rft.volume=21&rft.issue=3-4&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+Workplace+Behavioral+Health&rft.issn=15555240&rft_id=info:doi/10.1300%2FJ490v21n03_03 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care Services; Management; Human Services; Workplaces; Employee Assistance Programs; Natural Disasters DO - http://dx.doi.org/10.1300/J490v21n03_03 ER - TY - JOUR T1 - Accessing Care for U.S./Mexico Border Populations Living with HIV/AIDS: The Role of HRSA's HIV/AIDS Bureau and the Special Projects of National Significance AN - 61385582; 200702512 AB - The Health Resources Services Administration (HRSA) provides health-care to underserved areas in the U.S. and addresses disparities in health-care among U.S. populations. HRSA's Ryan White CARE Act provides HIV care and supportive services for persons with HIV and AIDS in the U.S. and its territories. Five projects were funded as Special Projects of National Significance (SPNS) from 2001-2005, to improve care and access to HIV services along the U.S.-Mexican Border. These projects developed culturally appropriate and innovative outreach strategies, expanded counseling and testing in border communities, assured continuity of care through intensive case management services and increased clinical capacity through provider training. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of HIV/AIDS & Social Services AU - Eldred, Lois AU - Cheever, Laura AU - Parham-Hopson, Deborah AD - Dept Health and Human Services, Health Resources Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Rockville. E-mail: LEldred@hrsa.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 7 EP - 13 PB - Haworth Press, Binghamton NY VL - 5 IS - 2 SN - 1538-1501, 1538-1501 KW - Cultural, HRSA, HIV outreach, HIV services, Ryan White Care Act, SPNS, U.S.-Mexican Border KW - Borders KW - Mexico KW - Acquired Immune Deficiency Syndrome KW - United States of America KW - Access KW - Health Care Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61385582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.atitle=Accessing+Care+for+U.S.%2FMexico+Border+Populations+Living+with+HIV%2FAIDS%3A+The+Role+of+HRSA%27s+HIV%2FAIDS+Bureau+and+the+Special+Projects+of+National+Significance&rft.au=Eldred%2C+Lois%3BCheever%2C+Laura%3BParham-Hopson%2C+Deborah&rft.aulast=Eldred&rft.aufirst=Lois&rft.date=2006-01-01&rft.volume=5&rft.issue=2&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.issn=15381501&rft_id=info:doi/10.1300%2FJ187v05n02_03 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-06-04 N1 - Number of references - 7 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States of America; Mexico; Borders; Acquired Immune Deficiency Syndrome; Access; Health Care Services DO - http://dx.doi.org/10.1300/J187v05n02_03 ER - TY - JOUR T1 - Health Spending Projections through 2015: Changes on the Horizon AN - 59948349; 2007-01500 AB - Growth in national health spending is projected to slow in 2005 to 7.4 percent, from a peak of 9.1 percent in 2002. Private health insurance premiums are projected to slow to 6.6 percent in 2005, with a rebound expected in 2007. The introduction of Medicare Part D drug coverage in 2006 produces a dramatic shift in spending across payers but has little net effect on aggregate spending growth. Health spending is expected to consistently outpace gross domestic product (GDP) over the coming decade, accounting for 20 percent of GDP by 2015. y. Adapted from the source document. JF - Health Affairs AU - Borger, Christine AU - Smith, Sheila AU - Truffer, Christopher AU - Keehan, Sean AU - Sisko, Andrea AU - Poisal, John AU - Clemens, M Kent AD - National Health Statistics Group, Office of Actuary, Centers for Medicare Services, Baltimore, MD DNHS@cms.hhs.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - w61 EP - w73 PB - Project HOPE, Bethesda MD IS - supplement SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Medical service - Costs KW - United States - Health policy - Financial aspects KW - Medicare - United States KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59948349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Health+Spending+Projections+through+2015%3A+Changes+on+the+Horizon&rft.au=Borger%2C+Christine%3BSmith%2C+Sheila%3BTruffer%2C+Christopher%3BKeehan%2C+Sean%3BSisko%2C+Andrea%3BPoisal%2C+John%3BClemens%2C+M+Kent&rft.aulast=Borger&rft.aufirst=Christine&rft.date=2006-01-01&rft.volume=&rft.issue=supplement&rft.spage=w61&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.25.w61 LA - English DB - PAIS Index N1 - Date revised - 2007-05-17 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States - Health policy - Financial aspects; Medicare - United States; Medical service - Costs DO - http://dx.doi.org/10.1377/hlthaff.25.w61 ER - TY - BOOK T1 - Hearing Loss Research at NIOSH: Reviews of Research Programs of the National Institute for Occupational Safety and Health AN - 58750880; 2007-23016 AB - The first report in the series Reviews of Research Programs of the National Institute for Occupational Safety and Health (NIOSH). Recommends that the NIOSH Hearing Loss Research Program foster effective leadership in program planning and implementation; further implement program evaluation efforts; gain access to additional intramural and extramural expertise, especially in epidemiology and noise control engineering; and initiate and sustain efforts to obtain surveillance data for occupational hearing loss and workplace noise exposure. Appendixes, References. JF - Institute of Medicine of the National Academies, 2006, 224 pp. AU - National Institute for Occupational Safety and Health Y1 - 2006///0, PY - 2006 DA - 0, 2006 EP - 224p PB - Institute of Medicine of the National Academies SN - 030910274X KW - Environment and environmental policy - Pollution and environmental degradation KW - United States - Occupational safety and health administration KW - Noise - Regulation KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58750880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=224p&rft.isbn=030910274X&rft.btitle=Hearing+Loss+Research+at+NIOSH%3A+Reviews+of+Research+Programs+of+the+National+Institute+for+Occupational+Safety+and+Health&rft.title=Hearing+Loss+Research+at+NIOSH%3A+Reviews+of+Research+Programs+of+the+National+Institute+for+Occupational+Safety+and+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.nap.edu/catalog.php?record_id=11721#toc LA - English DB - PAIS Index N1 - Date revised - 2007-11-01 N1 - Publication note - Institute of Medicine of the National Academies, 2006 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Information Rx: evaluation of a new informatics tool for physicians, patients, and libraries. AN - 57674217; 477381 AB - This paper reports selected results from two comprehensive evaluation studies of the Information Prescription (or "Information Rx") Program implementation conducted from 2002-05 by the American College of Physicians Foundation (ACPF) and the U.S. National Library of Medicine (NLM). In this Program physicians are provided with Information Prescription pads, analogous to pads used to prescribe medications, that are used to direct patients to the MedlinePlus web site and its contents that are applicable to a patient's health condition. The results describe the Program's potential to enhance patient education and interpersonal communication from physician and patient perspectives. The findings suggest once physicians adopt the use of an information prescription, they perceive they are providing an additional clinical service that enhances patient education and interpersonal communication. For physicians, participation in information prescription may improve patient communication, encourage information seeking, and lessen the number of poor quality Internet searches that patients frequently self-perform and bring to a doctor's office. Similarly, once patients receive a recommendation from a physician to seek health information on the web, patients may be more comfortable with health seeking on the Internet and discussing their findings with their doctor. The conclusions of the two evaluation studies imply an Information Prescription fosters a dialogue between providers and patients, helps patients use the Internet more effectively and seems to favorably impact patient education. As the medical community and patient advocacy groups continue to emphasize the importance of evidence-based information as the gold standard for accepted care, it can be expected that informatics tools such as Information Rx will come to play an increasingly important role as a vehicle to help identify and access high quality health information on the Internet. (Author abstract) JF - Information Services & Use AU - Siegel, Elliot R AU - Logan, Robert A AU - Harnsberger, Robert L AU - Cravedi, Kathleen AU - Krause, Jean A AU - Lyon, Becky AU - Hajarian, Karen AU - Uhl, Jonathan AU - Ruffin, Angela AU - Lindberg, Donald A B AD - U.S. National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20894, USA Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 1 EP - 10 PB - IOS Press VL - 26 IS - 1 SN - 0167-5265, 0167-5265 KW - Evaluation KW - Software KW - USA KW - Medical informatics KW - Doctor-patient communication KW - 10.13: SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57674217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Services+%26+Use&rft.atitle=Information+Rx%3A+evaluation+of+a+new+informatics+tool+for+physicians%2C+patients%2C+and+libraries.&rft.au=Siegel%2C+Elliot+R%3BLogan%2C+Robert+A%3BHarnsberger%2C+Robert+L%3BCravedi%2C+Kathleen%3BKrause%2C+Jean+A%3BLyon%2C+Becky%3BHajarian%2C+Karen%3BUhl%2C+Jonathan%3BRuffin%2C+Angela%3BLindberg%2C+Donald+A+B&rft.aulast=Siegel&rft.aufirst=Elliot&rft.date=2006-01-01&rft.volume=26&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Information+Services+%26+Use&rft.issn=01675265&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical informatics; Doctor-patient communication; Software; Evaluation; USA ER - TY - JOUR T1 - A Survey of Programs for Parents with Mental Illness and their Families: Identifying Common Elements to Build the Evidence Base AN - 57304597; 200915118 AB - Little is known about the effectiveness of interventions for families living with parental mental illness. Existing interventions offer information about successfully implemented treatments, which may demonstrate effectiveness in research. In the current study, directors of programs for parents with mental illness and their families were interviewed. Qualitative analyses revealed noteworthy similarities with respect to target population; funding; community context; agency context; mission, theoretical orientation, and assumptions; locus of care and essential services; desired outcomes; and moderators. Program similarities were identified to provide parameters for research, and to contribute to the development of testable hypotheses. Family-centered, strengths-based approaches were identified across program directors as critical to intervention success. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Hinden, Beth R AU - Biebel, Kathleen AU - Nicholson, Joanne AU - Henry, Alexis AU - Katz-Leavy, Judith AD - Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 21 EP - 38 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 33 IS - 1 SN - 1094-3412, 1094-3412 KW - Interventions KW - Mentally ill parents KW - Service provision KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=A+Survey+of+Programs+for+Parents+with+Mental+Illness+and+their+Families%3A+Identifying+Common+Elements+to+Build+the+Evidence+Base&rft.au=Hinden%2C+Beth+R%3BBiebel%2C+Kathleen%3BNicholson%2C+Joanne%3BHenry%2C+Alexis%3BKatz-Leavy%2C+Judith&rft.aulast=Hinden&rft.aufirst=Beth&rft.date=2006-01-01&rft.volume=33&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-005-9007-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mentally ill parents; Interventions; Service provision DO - http://dx.doi.org/10.1007/s11414-005-9007-x ER - TY - JOUR T1 - Collection and concentration of stratabound metals during progressive reduction of oxidized Revett strata; a 180 degrees variation of the red bed source model AN - 51514799; 2007-001962 JF - Northwest Geology AU - White, Brian G A2 - Gibson, Richard I. A2 - Thomas, Robert C. Y1 - 2006 PY - 2006 DA - 2006 SP - 49 EP - 55 PB - University of Montana, Department of Geology, Missoula, MT VL - 35 SN - 0096-7769, 0096-7769 KW - United States KW - silicates KW - mineral exploration KW - mineral deposits, genesis KW - upper Precambrian KW - stratabound deposits KW - sedimentary basins KW - Sanders County Montana KW - Noxon Arch KW - Prichard Formation KW - Moyie Fault KW - ground water KW - Belt Supergroup KW - Lincoln County Montana KW - sedimentary rocks KW - metallogeny KW - basins KW - copper ores KW - reduction KW - geochemistry KW - faults KW - Eh KW - red beds KW - Osburn Fault KW - Idaho KW - Pend Orielle Trough KW - Washington KW - Precambrian KW - oxidation KW - structural controls KW - smectite KW - Proterozoic KW - Flathead Trough KW - Montana KW - Mesoproterozoic KW - clay minerals KW - aquifers KW - models KW - provenance KW - Revett Quartzite KW - metal ores KW - sheet silicates KW - clastic rocks KW - facies KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51514799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Northwest+Geology&rft.atitle=Collection+and+concentration+of+stratabound+metals+during+progressive+reduction+of+oxidized+Revett+strata%3B+a+180+degrees+variation+of+the+red+bed+source+model&rft.au=White%2C+Brian+G&rft.aulast=White&rft.aufirst=Brian&rft.date=2006-01-01&rft.volume=35&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Northwest+Geology&rft.issn=00967769&rft_id=info:doi/ L2 - http://trgs.org/pubs.htm LA - English DB - GeoRef N1 - Conference title - 31st annual field conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 6 N1 - PubXState - MT N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - NWGYAR N1 - SubjectsTermNotLitGenreText - aquifers; basins; Belt Supergroup; clastic rocks; clay minerals; copper ores; Eh; facies; faults; Flathead Trough; geochemistry; ground water; Idaho; Lincoln County Montana; Mesoproterozoic; metal ores; metallogeny; mineral deposits, genesis; mineral exploration; models; Montana; Moyie Fault; Noxon Arch; Osburn Fault; oxidation; Pend Orielle Trough; Precambrian; Prichard Formation; Proterozoic; provenance; red beds; reduction; Revett Quartzite; Sanders County Montana; sedimentary basins; sedimentary rocks; sheet silicates; silicates; smectite; stratabound deposits; structural controls; United States; upper Precambrian; Washington ER - TY - BOOK T1 - Relative roles of bacteria and fungi in polycyclic aromatic hydrocarbon biodegradation and bioremediation of contaminated soils AN - 51478527; 2007-021076 JF - Fungi in biogeochemical cycles AU - Cerniglia, Carl E AU - Sutherland, John B A2 - Gadd, Geoffrey Michael Y1 - 2006 PY - 2006 DA - 2006 PB - Cambridge University Press, Cambridge SN - 0521845793 KW - soils KW - processes KW - biodegradation KW - pollutants KW - pollution KW - ecosystems KW - bioremediation KW - remediation KW - organic compounds KW - fungi KW - soil pollution KW - bacteria KW - hydrocarbons KW - polycyclic aromatic hydrocarbons KW - ecology KW - aromatic hydrocarbons KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51478527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cerniglia%2C+Carl+E%3BSutherland%2C+John+B&rft.aulast=Cerniglia&rft.aufirst=Carl&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0521845793&rft.btitle=Relative+roles+of+bacteria+and+fungi+in+polycyclic+aromatic+hydrocarbon+biodegradation+and+bioremediation+of+contaminated+soils&rft.title=Relative+roles+of+bacteria+and+fungi+in+polycyclic+aromatic+hydrocarbon+biodegradation+and+bioremediation+of+contaminated+soils&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 232 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Health plans respond to parity: managing behavioral health care in the federal employees health benefits program AN - 36443462; 3330024 AB - The government often uses the Federal Employees Health Benefits (FEHB) Program as a model for both public and private health policy choices. In 2001, the U.S. Office of Personnel Management (OPM) implemented full parity, requiring that FEHB carriers offer mental health and substance abuse benefits equal to general medical benefits. OPM instructed carriers to alter their benefit design but permitted them to determine whether they would manage care and what structures or processes they would use. This article reports on the experience of 156 carriers and the government-wide BlueCross and BlueShield Service Benefit Plan. Carriers dropped cost-restraining benefit limits. A smaller percentage also changed the management of the benefit, but these changes affected the care of many enrollees, making the overall parity effect noteworthy. Reprinted by permission of Blackwell Publishers JF - Milbank quarterly AU - Ridgely, M Susan AU - Burnam, M Audrey AU - Barry, Colleen L AU - Goldman, Howard H AU - Hennessy, Kevin D AD - RAND Corporation ; Yale University ; University of Maryland ; Substance Abuse and Mental Health Services Administration Y1 - 2006 PY - 2006 DA - 2006 SP - 201 EP - 218 VL - 84 IS - 1 SN - 0887-378X, 0887-378X KW - Sociology KW - Health care KW - Employees KW - Health insurance KW - Mental health KW - Working conditions KW - Policy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36443462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Milbank+quarterly&rft.atitle=Health+plans+respond+to+parity%3A+managing+behavioral+health+care+in+the+federal+employees+health+benefits+program&rft.au=Ridgely%2C+M+Susan%3BBurnam%2C+M+Audrey%3BBarry%2C+Colleen+L%3BGoldman%2C+Howard+H%3BHennessy%2C+Kevin+D&rft.aulast=Ridgely&rft.aufirst=M&rft.date=2006-01-01&rft.volume=84&rft.issue=1&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Milbank+quarterly&rft.issn=0887378X&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4207 3874 556; 7947 5772 7954; 5784 6592 4957 11923 11949 13521; 5775 13521; 13713 4214; 9628 ER - TY - JOUR T1 - The Genetic and Environmental Factors Involved in Benzidine Metabolism and Bladder Carcinogenesis in Exposed Workers AN - 21210364; 11197651 AB - Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other aromatic amines. Metabolic polymorphisms and bladder cancer in the context of occupational exposure to aromatic amines are also reviewed, and the environmental and genetic relationships of benzidine exposure and genetic susceptibility are outlined. Only a few studies of bladder cancer genetic susceptibility in populations exposed occupationally to arylamines have been published. The results of these case-control studies show conflicting results, reflecting metabolic differences between monoarylamines and diarylamines such as benzidine. Additional studies and pooled analyses of existing data are needed to establish if individuals are at higher risk of bladder cancer given the presence of certain alleles that make them more susceptible to this disease. JF - Frontiers in Bioscience AU - Carreon, T AU - LeMasters, G K AU - Ruder, A M AU - Schulte, P A AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 2889 EP - 2902 VL - 11 SN - 1093-9946, 1093-9946 KW - Genetics Abstracts; Toxicology Abstracts KW - Detoxification KW - Data processing KW - Urinary bladder KW - Gene polymorphism KW - Environmental factors KW - Cancer KW - Genetic relationship KW - Population genetics KW - amines KW - Risk factors KW - Reviews KW - Carcinogenesis KW - Metabolism KW - Aromatics KW - Occupational exposure KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=The+Genetic+and+Environmental+Factors+Involved+in+Benzidine+Metabolism+and+Bladder+Carcinogenesis+in+Exposed+Workers&rft.au=Carreon%2C+T%3BLeMasters%2C+G+K%3BRuder%2C+A+M%3BSchulte%2C+P+A&rft.aulast=Carreon&rft.aufirst=T&rft.date=2006-01-01&rft.volume=11&rft.issue=&rft.spage=2889&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Detoxification; Data processing; Urinary bladder; Gene polymorphism; Environmental factors; Cancer; Genetic relationship; Population genetics; amines; Reviews; Risk factors; Carcinogenesis; Occupational exposure; Aromatics; Metabolism ER - TY - JOUR T1 - Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival AN - 20962494; 8514023 AB - Research on mycobacteria-specific PE_PGRS genes indicates that they code for cell surface proteins that may influence virulence and the infection of host cells by mycobacteria. In the studies presented here, we have expressed the PE_PGRS 33 gene in a non-pathogenic fast-growing Mycobacterium smegmatis strain and demonstrated that it survives better in macrophage cultures, in vitro as well as in mice after intraperitoneal administration, than the parental strain containing the vector only or a strain expressing only the PE domain of PE_PGRS 33. In macrophages, enhanced colonization by the M. smegmatis expressing PE_PGRS 33 was associated with macrophage aggregation and clearance of macrophage monolayers, visible cell necrosis and significantly greater levels of TNF (TNF- alpha ) in the cultures compared with controls. The presence of macrophage cell necrosis was confirmed by measurement of significantly greater levels of lactate dehydrogenase and nucleosomes in the supernatants of the macrophage cultures infected with M. smegmatis expressing PE_PGRS 33. Antibodies directed against TNF partially reduced cytolysis, suggesting that this cytokine is critical but not sufficient for the observed macrophage necrosis and enhanced mycobacterial survival. These results extend earlier observations, which suggested that PE_PGRS proteins may have a role in the pathogenesis of mycobacterial disease and that there may be a specific role for these proteins in influencing host cell responses to infection. JF - Microbes and Infection AU - Dheenadhayalan, Veerabadran AU - Delogu, Giovanni AU - Brennan, Michael J AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA, Dheenadhayalan@cber.fda.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 262 EP - 272 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 8 IS - 1 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mycobacterium smegmatis KW - PE_PGRS genes KW - Tuberculosis KW - Tumor necrosis factor KW - Cell survival KW - Macrophages KW - Cell surface KW - Cell culture KW - Infection KW - L-Lactate dehydrogenase KW - Virulence KW - Colonization KW - Nucleosomes KW - Antibodies KW - Cytolysis KW - Cytokines KW - Tumor necrosis factor- alpha KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Expression+of+the+PE_PGRS+33+protein+in+Mycobacterium+smegmatis+triggers+necrosis+in+macrophages+and+enhanced+mycobacterial+survival&rft.au=Dheenadhayalan%2C+Veerabadran%3BDelogu%2C+Giovanni%3BBrennan%2C+Michael+J&rft.aulast=Dheenadhayalan&rft.aufirst=Veerabadran&rft.date=2006-01-01&rft.volume=8&rft.issue=1&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2005.06.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Cell surface; Cell culture; Infection; L-Lactate dehydrogenase; Virulence; Colonization; Antibodies; Nucleosomes; Cytolysis; Cytokines; Tumor necrosis factor- alpha; Mycobacterium smegmatis DO - http://dx.doi.org/10.1016/j.micinf.2005.06.021 ER - TY - JOUR T1 - Database composition can affect the structure-activity relationship prediction AN - 20925531; 6991738 AB - The percent active (A) and inactive (I) chemicals in a database can directly affect the sensitivity (% active chemicals predicted correctly) and specificity (% inactive chemicals predicted correctly) of structure-activity relationship (SAR) analyses. Subdividing the National Center for Toxicological Research (NCTR) liver cancer database (NCTRlcdb) into various A/I ratios, which varied from 0.2 to 5.5, resulted in sensitivity/specificity ratios that varied from 0.1 to 6.5. As percent active chemicals increased (increasing A/I ratio), the sensitivity rose, the specificity decreased, and the concordance (% total chemicals predicted correctly) remained fairly constant. The numbers of chemicals in the various data sets ranged from 187 to 999 and appeared to have no affect on any of the 3 predictors of sensitivity, specificity, or concordance. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Young, J F AU - Tsai, Chen-An AU - Chen, J J AU - Latendresse, J R AU - Kodell, R L AD - Division of Biometry and Risk Assessment, National Center for Toxicological Research/PDA, Jefferson, AR 72079-9502, USA, jyoung@nctr.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1527 EP - 1540 VL - 69 IS - 15-16 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - Databases KW - Liver cancer KW - Structure-activity relationships KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20925531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Database+composition+can+affect+the+structure-activity+relationship+prediction&rft.au=Young%2C+J+F%3BTsai%2C+Chen-An%3BChen%2C+J+J%3BLatendresse%2C+J+R%3BKodell%2C+R+L&rft.aulast=Young&rft.aufirst=J&rft.date=2006-01-01&rft.volume=69&rft.issue=15-16&rft.spage=1527&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390500468746 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Databases; Liver cancer; Structure-activity relationships DO - http://dx.doi.org/10.1080/15287390500468746 ER - TY - JOUR T1 - Interaction between primary alveolar macrophages and primary alveolar type ii cells under basal conditions and after lipopolysaccharide or quartz exposure AN - 20923638; 6910885 AB - Intercellular communications between alveolar macrophages (AM) and alveolar epithelial type II (TII) cells have been suggested to be important in cellular responses. The main objective of this study was to improve our understanding of the interactions between AM and TII cells that might occur in the lung. In the present investigation, this interaction was studied under different interaction conditions (transwell or mixed coculture) and different exposure conditions (basal, lipopolysaccharide [LPS] exposure, or silica exposure). Studies also attempted different approaches to identify specific mediator(s) involved in this interaction. The following findings were made: (1) Surfactant released from TII cells appears to exert an inhibitory effect on AM activity. (2) Basal transwell coculture conditions are better than mixed coculture conditions to study AM/TII cell interactions, since the inhibitory effect of the surfactant in the transwell coculture is minimized. (3) AM/TII cell interaction is dependent on cell culture (transwell vs mixed) and exposure conditions. (4) Oxidants, tumor necrosis factor (TNF)- alpha , interleukin (IL)-1 beta , prostaglandins, and leukotrienes probably do not independently affect the AM/TII intercellular interaction; instead, they appear to indirectly modulate the complex pathways of AM/TII communication. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Kanj, R S AU - Kang, J L AU - Castranova, V AD - NIOSH, 1095 Willowdale Road, M/S2O15, Morgantown, WV 26505, USA, vicl@cdc.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1097 EP - 1116 VL - 69 IS - 11-12 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - Leukotrienes KW - Macrophages KW - Tumor necrosis factor KW - Prostaglandins KW - Interleukins KW - Communication KW - Cell culture KW - Silica KW - Lung KW - Quartz KW - Lipopolysaccharides KW - Cell interactions KW - Surfactants KW - Oxidants KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20923638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Interaction+between+primary+alveolar+macrophages+and+primary+alveolar+type+ii+cells+under+basal+conditions+and+after+lipopolysaccharide+or+quartz+exposure&rft.au=Kanj%2C+R+S%3BKang%2C+J+L%3BCastranova%2C+V&rft.aulast=Kanj&rft.aufirst=R&rft.date=2006-01-01&rft.volume=69&rft.issue=11-12&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F14736480500360504 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Leukotrienes; Tumor necrosis factor; Prostaglandins; Communication; Interleukins; Cell culture; Silica; Lung; Quartz; Lipopolysaccharides; Cell interactions; Surfactants; Oxidants DO - http://dx.doi.org/10.1080/14736480500360504 ER - TY - JOUR T1 - A sigma super(28)-Regulated Nonflagella Gene Contributes to Virulence of Campylobacter jejuni 81-176 AN - 20841231; 6576975 AB - A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure. JF - Infection and Immunity AU - Goon, Scarlett AU - Ewing, Cheryl P AU - Lorenzo, Maria AU - Pattarini, Dawn AU - Majam, Gary AU - Guerry, Patricia AD - Enteric Diseases Department, Naval Medial Research Center, Silver Spring, Maryland 20910. Food and Drug Administration MOD1, Beltsville, Maryland Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 769 EP - 772 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - Cj0977 protein KW - Genetics Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Mustela putorius furo KW - Virulence KW - Epithelial cells KW - Diarrhea KW - Campylobacter jejuni KW - Gene regulation KW - Intestine KW - Models KW - Flagella KW - J 02832:Antigenic properties and virulence KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20841231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=A+sigma+super%2828%29-Regulated+Nonflagella+Gene+Contributes+to+Virulence+of+Campylobacter+jejuni+81-176&rft.au=Goon%2C+Scarlett%3BEwing%2C+Cheryl+P%3BLorenzo%2C+Maria%3BPattarini%2C+Dawn%3BMajam%2C+Gary%3BGuerry%2C+Patricia&rft.aulast=Goon&rft.aufirst=Scarlett&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Epithelial cells; Diarrhea; Gene regulation; Intestine; Flagella; Models; Mustela putorius furo; Campylobacter jejuni ER - TY - JOUR T1 - Moulds, yeasts and aerobic plate counts in ginseng supplements AN - 20736816; 6821593 AB - Forty six ginseng supplement samples including Siberian ginseng root, Chinese ginseng herb and root, and American ginseng root and extract were purchased from retail in the Washington, DC area and from Penn Herb Co. (Philadelphia, PA) and tested for mould and yeast (MY) contamination and the presence of aerobic mesophilic bacteria (APC). Results indicated that 100% of the Siberian ginseng samples were contaminated with fungi and bacteria. MY counts ranged from 8.0 x 10 super(2) to 1.4 x 10 super(3) cfu/g whereas the APCs were between 2.3 x 10 super(4) and 1.0 x 10 super(6) cfu/g. Most common fungi encountered in this commodity were Penicillium spp., Eurotium rubrum, E. chevalieri and Rhizopus spp. Seventy-eight percent of the Chinese ginseng herb samples were contaminated with fungi and 89% with bacteria at levels ranging between - 100 and 6.0 x 10 super(4) and - 100 and 1.2 x 10 super(6) cfu/g, respectively. Moulds commonly isolated were Alternaria alternata, Aspergillus niger, Aspergillus spp., Cladosporium spp., E. chevalieri, Penicillium spp. and Rhizopus spp. Fifty six percent of the Chinese ginseng root samples tested contained fungi (A. niger, Rhizopus spp. and yeasts), and 100% contained bacteria. Fungal counts ranged between - 100 and 1.4 x 10 super(3) cfu/g and APCs were between 3.0 x 10 super(2) and 6.8 x 10 super(5) cfu/g. Forty-eight percent of the American ginseng root samples contained moulds and 30% showed bacterial contamination. MY counts were between - 100 and 4.3 x 10 super(5) cfu/g whereas APCs were between - 100 and 4.5 x 10 super(4) cfu/g. A. flavus was isolated from 9% and Penicillium spp. were recovered from 39% of the tested samples. This is the first report of A. flavus contamination in ginseng supplements. No moulds or yeasts were found in ginseng extract, but 50% of these samples contained bacteria at levels ranging between - 100 and 1.0 x 10 super(3) cfu/g. JF - International Journal of Food Microbiology AU - Tournas, V H AU - Katsoudas, Eugenia AU - Miracco, E J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA, vtournas@cfsan.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 178 EP - 181 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 108 IS - 2 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Moulds KW - Yeasts KW - APCs KW - Ginseng supplements KW - Mesophilic bacteria KW - Aspergillus flavus KW - Penicillium KW - Contamination KW - Fungi KW - Aerobic bacteria KW - Roots KW - Ginseng KW - Food contamination KW - Alternaria alternata KW - Colony-forming cells KW - Dietary supplements KW - Eurotium KW - Rhizopus KW - Antigen-presenting cells KW - Cladosporium KW - Herbs KW - Aspergillus niger KW - A 01017:Human foods KW - J 02420:Plant Diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20736816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Moulds%2C+yeasts+and+aerobic+plate+counts+in+ginseng+supplements&rft.au=Tournas%2C+V+H%3BKatsoudas%2C+Eugenia%3BMiracco%2C+E+J&rft.aulast=Tournas&rft.aufirst=V&rft.date=2006-01-01&rft.volume=108&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2005.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mesophilic bacteria; Contamination; Dietary supplements; Fungi; Colony-forming cells; Aerobic bacteria; Roots; Ginseng; Antigen-presenting cells; Food contamination; Herbs; Aspergillus flavus; Penicillium; Eurotium; Rhizopus; Cladosporium; Aspergillus niger; Alternaria alternata DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2005.11.009 ER - TY - JOUR T1 - Kaposis sarcoma risk among transplant recipients in the United States (1993-2003) AN - 20723963; 7109123 AB - Kaposis sarcoma (KS) risk is high in immunosuppressed transplant recipients. KS develops in recipients with pre-existing infection with human herpesvirus 8 (HHV-8), the causative agent for KS, but it can also occur in recipients infected by donors. The relative importance of these sources of infection in recipients in the United States is unknown. We report recipient and donor characteristics associated with KS among transplant recipients in the United States. KS risk, after solid organ transplantation during 1993-2003, was analyzed using data from the Organ Procurement and Tissue Network. Associations were determined using proportional hazards regression. Sixtyfive KS cases were identified among 234,127 transplants (incidence 8.8 per 100,000 person-years). Most cases occurred in the first 2 years after transplantation (incidence 12.5 per 100,000 person-years). KS risk increased steadily with recipient age (p sub(trend) < 0.001) and was associated with the recipient being male (HR 1.8, 95% CI, 1.0-3.2), Hispanic (2.1, 1.1-3.8) and a non-U.S. citizen (3.9, 1.8- 8.6). Mismatch at the HLA-B locus, but not at HLA-A or HLA-DR loci, was associated with heightened risk (HR 3.6, 95%CI 1.1-11 for 1-2 vs. 0 HLA-B mismatches). KS was unrelated to donor characteristics and was not significantly related to use of specific antirejection medications. Our study found that KS incidence was low among transplant recipients in the United States, but it was associated with recipient age, sex and citizenship, perhaps reflecting pre- existing HHV-8 infection. The high KS risk immediately posttransplant and in persons with HLA-B mismatch highlights the role of immunosuppression and/or immune stimulation in KS pathogenesis. JF - International Journal of Cancer AU - Mbulaiteye, Sam M AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, mbulaits@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 2685 EP - 2691 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 11 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - human herpesvirus 8 KW - immunosuppression KW - cancer KW - chimerism KW - Histocompatibility antigen HLA KW - Age KW - Donors KW - Data processing KW - Human herpesvirus 8 KW - citizenship KW - Infection KW - Organs KW - Cancer KW - USA KW - Risk factors KW - infection KW - Sarcoma KW - Drugs KW - Ethnic groups KW - Immunosuppression KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Kaposis+sarcoma+risk+among+transplant+recipients+in+the+United+States+%281993-2003%29&rft.au=Mbulaiteye%2C+Sam+M%3BEngels%2C+Eric+A&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2006-01-01&rft.volume=119&rft.issue=11&rft.spage=2685&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Donors; Data processing; Risk factors; Sarcoma; Infection; Immunosuppression; Age; infection; citizenship; Drugs; Organs; Ethnic groups; Cancer; Human herpesvirus 8; USA DO - http://dx.doi.org/10.1002/ijc.22233 ER - TY - JOUR T1 - Risk assessment in drug development: autoimmunity AN - 20718457; 6833581 AB - Autoimmunity is a physiological condition in which the immune system responds to normal tissues as if they were foreign pathogens. If this reaction produces pathology, it is referred to as autoimmune disease. Many human diseases (most often chronic in nature) appear to have an autoimmune basis. No model exists that has proven to be sufficiently predictive to screen drugs for potential to induce autoimmunity (hazard identification); thus, it seems somewhat illogical to consider this as an example of risk assessment However, given the knowledge currently available, it is at least conceivable that drugs could be identified as having the potential to produce autoimmune reactions, and especially to predict the conditions under which autoimmune disease may be induced. This has proven to be an especially important topic with protein drugs designed to replace endogenous molecules. Immunogenicity, thought to be an important component of protein drug-induced autoimmunity, can be modeled in animals. However, interpretation of results with respect to prediction of ability to induce autoimmune disease remains a serious challenge. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Hastings, K L AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 22, Rm. 6480, Silver Spring, MD 20993, USA, hastingsk@cder.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 893 EP - 898 VL - 69 IS - 9-10 SN - 1528-7394, 1528-7394 KW - Risk Abstracts; Toxicology Abstracts KW - Risk assessment KW - Pathology KW - immune system KW - Immune system KW - Physiology KW - Autoimmune diseases KW - autoimmune diseases KW - immunogenicity KW - Drug development KW - Pathogens KW - Immunosuppressive agents KW - Models KW - Immunogenicity KW - Proteins KW - Drugs KW - X 24222:Analytical procedures KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20718457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Risk+assessment+in+drug+development%3A+autoimmunity&rft.au=Hastings%2C+K+L&rft.aulast=Hastings&rft.aufirst=K&rft.date=2006-01-01&rft.volume=69&rft.issue=9-10&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390600591736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Immunogenicity; Immune system; Autoimmune diseases; Drug development; Pathogens; Immunosuppressive agents; Drugs; Models; immune system; Pathology; Physiology; immunogenicity; autoimmune diseases; Proteins DO - http://dx.doi.org/10.1080/15287390600591736 ER - TY - JOUR T1 - The Characterization of Airborne Occupational Safety and Health Hazards in Selected Small Businesses; Manufacturing Wood Pallets AN - 20519277; 6727503 AB - Researchers from the National Institute for Occupational Safety and Health (NIOSH) investigated occupational safety and health concerns in the small business wood pallet manufacturing industry because of an injury rate (2000) 226% greater than that for general industry. NIOSH investigators conducted walk-through evaluations at seven wood pallet manufacturing companies, and returned to four of them to take environmental measurements. Carbon monoxide (CO) levels, noise levels, and total particulate were measured, ergonomic observations made, and occupational safety practices analyzed at each of the four facilities where measurements were taken. The focus of this study is the evaluation of airborne particulate and carbon monoxide exposures for the purpose of determining areas of potentially high exposures. This knowledge can guide the plant owner or health professional to determine whether further measurements are necessary and where they might be needed. Safety factors and physical Stressors (noise and ergonomic Stressors) were described in a previously published companion paper. Although we did not take 8 h samples, we did find certain exposures that were potentially of concern to the small business owner. The main findings of this investigation were as follows: 1) CO levels in three plants, for the time periods measured, were less than the OSHA permissible exposure limit (PEL) of 50 parts per million (ppm) for an 8-h TWA. Three measurements, all from one plant, were due to a older and defective forklift and were above 50 ppm. 2) Total dust measures ranged from 0.86 to 1.67 mg/m super(3), taken adjacent to an operating machine cutting hardwood and measured up to 6 min. The American Conference of Governmental Industrial Hygienists (ACGIH) guideline for hardwood dust is 1.0 mg/m super(3), again for an 8-h TWA. JF - Industrial Health AU - Malkin, R AU - Lentz, T J AU - Topmiller, J AU - Hudock, S D AU - Niemeier, R W AD - National Institute for Occupational Safety and Health, Education and Information Division, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 58 EP - 63 VL - 44 IS - 1 SN - 0019-8366, 0019-8366 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Manufacturing industry KW - Federal regulations KW - Injuries KW - Conferences KW - Occupational safety KW - Noise levels KW - Wood KW - Particulates KW - Hardwoods KW - Dust KW - Carbon monoxide KW - Airborne particulates KW - Occupational exposure KW - Ergonomics KW - X 24240:Miscellaneous KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20519277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=The+Characterization+of+Airborne+Occupational+Safety+and+Health+Hazards+in+Selected+Small+Businesses%3B+Manufacturing+Wood+Pallets&rft.au=Malkin%2C+R%3BLentz%2C+T+J%3BTopmiller%2C+J%3BHudock%2C+S+D%3BNiemeier%2C+R+W&rft.aulast=Malkin&rft.aufirst=R&rft.date=2006-01-01&rft.volume=44&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Special issue: Occupational health in small-scale enterprises and the informal sector. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Carbon monoxide; Conferences; Injuries; Airborne particulates; Hardwoods; Dust; Manufacturing industry; Federal regulations; Occupational safety; Noise levels; Wood; Particulates; Ergonomics; Occupational exposure ER - TY - JOUR T1 - Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse AN - 20262884; 7281426 AB - A major goal of drug abuse research is to identify and understand drug- induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine if different drugs of abuse effect changes in gene expression that converge in common molecular pathways. Microarray analysis was employed to assay brain gene expression in postmortem anterior prefrontal cortex x28; aPFCx29; from 42 human cocaine, cannabis and/or phencyclidine abuse cases and 30 control cases, which were characterized by toxicology and drug abuse history. Common transcriptional changes were demonstrated for a majority of drug abuse cases x28; N src="corehtml/pmc/pmcents/thinsp.gif" border="0" alt=" " />x3d; src="corehtml/pmc/pmcents/thinsp.gif" border="0" alt=" " />34x29; , representing a number of consistently changed functional classes: Calmodulin- related transcripts x28; CALM1, CALM2, CAMK2Bx29; were decreased, while transcripts related to cholesterol biosynthesis and trafficking x28; FDFT1, APOL2, SCARB1x29; , and Golgi/endoplasmic reticulum x28; ERx29; functions x28; SEMA3B, GCC1x29; were all increased. Quantitative PCR validated decreases in calmodulin 2 x28; CALM2x29; mRNA and increases in apolipoprotein L, 2 x28; APOL2x29; and semaphorin 3B x28; SEMA3Bx29; mRNA for individual cases. A comparison between control cases with and without cardiovascular disease and elevated body mass index indicated that these changes were not due to general cellular and metabolic stress, but appeared specific to the use of drugs. Therefore, humans who abused cocaine, cannabis and/or phencyclidine share a decrease in transcription of calmodulin-related genes and increased transcription related to lipid/cholesterol and Golgi/ER function. These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers. JF - PLoS ONE AU - Lehrmann, Elin AU - Colantuoni, Carlo AU - Deep-Soboslay, Amy AU - Becker, Kevin G AU - Lowe, Ross AU - Huestis, Marilyn A AU - Hyde, Thomas M AU - Kleinman, Joel E AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 IS - 1 SN - 1932-6203, 1932-6203 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Article No. e114 KW - Golgi apparatus KW - Apolipoproteins KW - Lipids KW - Plasticity (synaptic) KW - Drug abuse KW - DNA microarrays KW - Gene expression KW - Endoplasmic reticulum KW - Cannabis KW - Polymerase chain reaction KW - Drug addiction KW - Cocaine KW - Calcium-binding protein KW - Brain KW - Transcription KW - Stress KW - Cholesterol KW - Drug dependence KW - Decision making KW - Phencyclidine KW - Calmodulin KW - Cardiovascular diseases KW - Body mass index KW - semaphorins KW - Cortex (prefrontal) KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20262884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Transcriptional+Changes+Common+to+Human+Cocaine%2C+Cannabis+and+Phencyclidine+Abuse&rft.au=Lehrmann%2C+Elin%3BColantuoni%2C+Carlo%3BDeep-Soboslay%2C+Amy%3BBecker%2C+Kevin+G%3BLowe%2C+Ross%3BHuestis%2C+Marilyn+A%3BHyde%2C+Thomas+M%3BKleinman%2C+Joel+E%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2006-01-01&rft.volume=1&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0000114. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Golgi apparatus; Apolipoproteins; Lipids; Drug abuse; Plasticity (synaptic); DNA microarrays; Gene expression; Endoplasmic reticulum; Cannabis; Polymerase chain reaction; Cocaine; Drug addiction; Calcium-binding protein; Brain; Stress; Transcription; Cholesterol; Decision making; Drug dependence; Phencyclidine; Calmodulin; Cardiovascular diseases; Body mass index; semaphorins; Cortex (prefrontal) DO - http://dx.doi.org/10.1371/journal.pone.0000114. ER - TY - JOUR T1 - Cloning of Replication-Incompetent Herpes Simplex Viruses as Bacterial Artificial Chromosomes to Facilitate Development of Vectors for Gene Delivery into Differentiated Neurons AN - 20245804; 6700598 AB - We have previously described the adaptation of a tetracycline-regulated system of gene expression for herpes simplex virus (HSV) vectors and demonstrated that such a system was capable of inducible foreign gene expression in irreversibly differentiated neurons. These studies suggested that such gene delivery vectors would be especially useful for studying the neuron in vitro. Here, we describe the cloning of a replication-incompetent HSV vector as a bacterial artificial chromosome (BAC) to facilitate vector construction. Using prokary-otic genetic techniques for allele replacement, we demonstrate the ease of manipulation of the BAC-containing vector, including the construction of vector mutations for which there is no simple phenotypic selection. Such constructions include the insertion of a tetraeycline-regulated gene cassette into the VL41 gene for regulated gene expression and the mutation of the UL48 gene to reduce vector toxicity. In addition, HSV vectors cloned as BACs can be sequentially modified to make multiple changes to the vector platform. Finally, using the BAC system, we constructed an HSV vector that expressed an inducible human superoxide dismutase-1 (SOD1) gene for delivery into differentiated human NT-neurons (cells of the human embryonal carcinoma cell line NT2, which differentiate irreversibly into postmitotic neuron-like cells after treatment with retinoic acid). The results indicated that there is appreciable expression of SOD1 from this HSV vector in the presence of doxycycline and that vector-expressed SOD1 interacts with endogenous SOD1. Thus, the BAC system provides a practicable platform for construction and manipulation of HSV vectors that are suitable for gene delivery into postmitotic neurons in vitro. JF - Human Gene Therapy AU - Schmeisser, F AU - Weir, J P AD - Division of Viral Products, HFM-457, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA, weirj@cber.fda.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 93 EP - 104 VL - 17 IS - 1 SN - 1043-0342, 1043-0342 KW - HSV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Adaptations KW - Gene therapy KW - Retinoic acid KW - Cloning vectors KW - Toxicity KW - Tetracyclines KW - Herpes simplex KW - Expression vectors KW - Gene expression KW - Bacterial artificial chromosomes KW - Tumor cell lines KW - Gene transfer KW - Superoxide dismutase KW - Insertion KW - Neurons KW - Superoxide KW - Neurotrophin 2 KW - Herpes simplex virus KW - Mutation KW - Doxycycline KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - W3 33181:Gene therapy vectors KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - V 22310:Genetics, Taxonomy & Structure KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20245804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Cloning+of+Replication-Incompetent+Herpes+Simplex+Viruses+as+Bacterial+Artificial+Chromosomes+to+Facilitate+Development+of+Vectors+for+Gene+Delivery+into+Differentiated+Neurons&rft.au=Schmeisser%2C+F%3BWeir%2C+J+P&rft.aulast=Schmeisser&rft.aufirst=F&rft.date=2006-01-01&rft.volume=17&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Adaptations; Gene therapy; Retinoic acid; Cloning vectors; Toxicity; Tetracyclines; Herpes simplex; Bacterial artificial chromosomes; Gene expression; Expression vectors; Tumor cell lines; Insertion; Superoxide dismutase; Gene transfer; Superoxide; Neurons; Neurotrophin 2; Mutation; Doxycycline; Herpes simplex virus ER - TY - JOUR T1 - Application of Pharmacogenomics in Clinical Pharmacology AN - 20236869; 6757575 AB - Many factors can affect a patient's response to a drug. These include intrinsic factors such as age, gender, race/ethnicity, genetics, disease states, organ dysfunctions, and other physiological changes, including pregnancy, lactation, and extrinsic factors such as smoking, diet (food, juice, dietary supplements), and concomitant medications (ICH E5, 1998 and 2004). The interplay of genotypes of the enzymes, transporters and receptors, among other factors (such as concomitant medications and disease states), can affect the risk/benefit ratio for individual patients. This commentary discusses when the genomic information should be obtained during drug development and when it is to be assimilated into labeling and standards of care that can be used to "individualize" drug therapy and become one of the pillars of "personalized medicine". JF - Toxicology Mechanisms and Methods AU - Huang, S-M AU - Goodsaid, F AU - Rahman, A AU - Frueh, F AU - Lesko, L J AD - Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 89 EP - 99 VL - 16 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Diets KW - Age KW - Pharmacology KW - pharmacogenomics KW - Food KW - Juices KW - Enzymes KW - Drug development KW - Genotypes KW - Pregnancy KW - Lactation KW - Smoking KW - Dietary supplements KW - genomics KW - Drugs KW - Races KW - Ethnic groups KW - X 24250:Reviews KW - G 07730:Development & Cell Cycle KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Application+of+Pharmacogenomics+in+Clinical+Pharmacology&rft.au=Huang%2C+S-M%3BGoodsaid%2C+F%3BRahman%2C+A%3BFrueh%2C+F%3BLesko%2C+L+J&rft.aulast=Huang&rft.aufirst=S-M&rft.date=2006-01-01&rft.volume=16&rft.issue=2-3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376520600558333 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Age; pharmacogenomics; Pharmacology; Food; Juices; Enzymes; Drug development; Genotypes; Lactation; Pregnancy; Smoking; Dietary supplements; genomics; Drugs; Ethnic groups; Races DO - http://dx.doi.org/10.1080/15376520600558333 ER - TY - JOUR T1 - An Integrated Study of Acute Effects of Valproic Acid in the Liver Using Metabonomics, Proteomics, and Transcriptomics Platforms AN - 20225915; 7231838 AB - An integrated omics approach was undertaken in order to elucidate a systems biology level understanding of the acute hepatotoxcity of valproic acid (VPA). Metabonomics, proteomics and gene expression microarray platforms were employed in this systems biology study. CD-1 female pregnant mice were injected subcutaneously with 600 mg/kg VPA or vehicle control. Urine, serum, and liver tissue were collected at 6, 12, and 24 h after dosing. Principal component analysis (PCA) of the metabonomics data showed clustering of the dosed groups away from the controls for the urine samples. Looser clustering was seen in the other sample sets investigated. However, VPA administration resulted in altered glucose concentrations in urine samples at 12 and 24 h and in aqueous liver tissue extracts at 12 h after VPA administration. Proteomics studies identified two proteins, glycogen phosphorylase and amylo-1,6-glucosidase, which were increased in dosed animals relative to control. Both of these proteins are involved in converting glycogen to glucose. Examination of the expression of 20,000 liver genes did not reveal significantly altered expression at 6, 12, or 24 h after VPA exposure. The combined studies indicated a perturbation in the glycogenolysis pathway following administration of VPA. JF - OMICS: A Journal of Integrative Biology AU - Schnackenberg, L K AU - Jones, R C AU - Thyparambil, S AU - Taylor, J T AU - Han, T AU - Tong, W AU - Hansen, D K AU - Fuscoe, J C AU - Edmondson, R D AU - Beger, R D AU - Dragan, Y P AD - The Division of Systems Toxicology and Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA, Richard.Beger@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1 EP - 14 VL - 10 IS - 1 SN - 1536-2310, 1536-2310 KW - Toxicology Abstracts; Genetics Abstracts KW - Data processing KW - Amylo-1,6-glucosidase KW - Glucose KW - Glycogen phosphorylase KW - DNA microarrays KW - Glycogen KW - Pregnancy KW - Gene expression KW - Acute effects KW - Urine KW - Principal components analysis KW - Valproic acid KW - Liver KW - proteomics KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20225915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=OMICS%3A+A+Journal+of+Integrative+Biology&rft.atitle=An+Integrated+Study+of+Acute+Effects+of+Valproic+Acid+in+the+Liver+Using+Metabonomics%2C+Proteomics%2C+and+Transcriptomics+Platforms&rft.au=Schnackenberg%2C+L+K%3BJones%2C+R+C%3BThyparambil%2C+S%3BTaylor%2C+J+T%3BHan%2C+T%3BTong%2C+W%3BHansen%2C+D+K%3BFuscoe%2C+J+C%3BEdmondson%2C+R+D%3BBeger%2C+R+D%3BDragan%2C+Y+P&rft.aulast=Schnackenberg&rft.aufirst=L&rft.date=2006-01-01&rft.volume=10&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=OMICS%3A+A+Journal+of+Integrative+Biology&rft.issn=15362310&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Amylo-1,6-glucosidase; Glucose; Glycogen phosphorylase; DNA microarrays; Glycogen; Pregnancy; Acute effects; Gene expression; Urine; Valproic acid; Principal components analysis; Liver; proteomics ER - TY - JOUR T1 - Exploring Genotypic and Phenotypic Diversify of Microbes Using Microarray Approaches AN - 20075381; 6757577 AB - Application of genome-scale analysis like DNA microarray technology has revolutionized multiple scientific disciplines. Herein, a next generation of DNA microarrays, a DNA tiling approach that allows high throughput sampling of genomes with single-nucleotide precision, is described. As methods revealing a genomic scale examination of cellular phenotypes offer keen insights for genomic analyses, a high throughput system for whole cell phenotyping is similarly detailed. The merit of these technologies in discriminating pathogenic and commensal strains of microbes is emphasized using the microbe, Escherichia coli, as an example. Deployment of microarray strategies to assess closely-related microbial strains should help address diversity of organisms in their feral settings. JF - Toxicology Mechanisms and Methods AU - Mukherjee, A AU - Jackson, SA AU - LeClerc, E AU - Cebula, T A AD - Division of Molecular Biology (HFS-025), Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, 20708, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 121 EP - 128 VL - 16 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Genomes KW - Phenotyping KW - Genomic analysis KW - Escherichia coli KW - Commensals KW - Sampling KW - DNA microarrays KW - W 30910:Imaging KW - A 01490:Miscellaneous KW - X 24221:Toxicity testing KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20075381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Exploring+Genotypic+and+Phenotypic+Diversify+of+Microbes+Using+Microarray+Approaches&rft.au=Mukherjee%2C+A%3BJackson%2C+SA%3BLeClerc%2C+E%3BCebula%2C+T+A&rft.aulast=Mukherjee&rft.aufirst=A&rft.date=2006-01-01&rft.volume=16&rft.issue=2-3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376520600558473 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Phenotyping; Genomic analysis; Commensals; Sampling; DNA microarrays; Escherichia coli DO - http://dx.doi.org/10.1080/15376520600558473 ER - TY - JOUR T1 - Evaluation of An Alkaline Phosphatase-Labeled Oligonucleotide Probe for the Detection and Enumeration of the Thermostable-Related Hemolysin (Trh) Gene of Vibrio Parahaemolyticus AN - 20001049; 7313582 AB - Reliable methods are needed to detect total and pathogenic Vibrio parahaemolyticus. One marker of V. parahaemolyticus virulence is the thermostable-related hemolysin. We developed an alkaline phosphatase-labeled DNA probe method for the specific detection and enumeration of trh-positive V. parahaemolyticus by colony hybridization. The probe was tested against a panel of 200 bacterial strains and determined to be specific for trh- positive V. parahaemolyticus. Additionally, the trh alkaline phosphatase probe colony hybridization was successfully used to detect and enumerate trh-positive V. parahaemolyticus in seafood and water samples collected from the United States and the United Kingdom. JF - Journal of Food Protection AU - Nordstrom, Jessica L AU - Rangdale, Rachel AU - Vickery, Michael CL AU - Phillips, Andrea MB AU - Murray, Shelley L AU - Wagley, Sariqa AU - Depaola, Angelo AD - U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville Drive, P.O. Box 158, Dauphin Island, Alabama 36528, USA Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 2770 EP - 2772 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com] VL - 69 IS - 11 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Pathogenic bacteria KW - DNA probes KW - Probes KW - Microbial contamination KW - Strains KW - Oligonucleotides KW - Public health KW - Virulence KW - USA KW - Colonies KW - Thyrotropin-releasing hormone KW - Alkaline phosphatase KW - hemolysin KW - Vibrio parahaemolyticus KW - Seafood KW - Disease detection KW - Hemolysins KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria KW - A 01300:Methods KW - J 02450:Ecology KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Evaluation+of+An+Alkaline+Phosphatase-Labeled+Oligonucleotide+Probe+for+the+Detection+and+Enumeration+of+the+Thermostable-Related+Hemolysin+%28Trh%29+Gene+of+Vibrio+Parahaemolyticus&rft.au=Nordstrom%2C+Jessica+L%3BRangdale%2C+Rachel%3BVickery%2C+Michael+CL%3BPhillips%2C+Andrea+MB%3BMurray%2C+Shelley+L%3BWagley%2C+Sariqa%3BDepaola%2C+Angelo&rft.aulast=Nordstrom&rft.aufirst=Jessica&rft.date=2006-01-01&rft.volume=69&rft.issue=11&rft.spage=2770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Virulence; Pathogenic bacteria; Disease detection; Microbial contamination; Seafood; Strains; Public health; Colonies; Alkaline phosphatase; Thyrotropin-releasing hormone; hemolysin; DNA probes; Probes; Hemolysins; Oligonucleotides; Vibrio parahaemolyticus; USA ER - TY - JOUR T1 - Characterization of Antimicrobial-Resistant Salmonella Isolated from Imported Foods AN - 19989499; 6965222 AB - Two-hundred eight Salmonella isolates recovered from over 5,000 imported foods entering the United States in 2001 were tested for antimicrobial susceptibilities and further characterized for quinolone resistance mechanisms, integron carriage, and genetic relatedness. Salmonella Weltevreden (20%), Salmonella Newport (6%), Salmonella Lexington (5%), and Salmonella Thompson (4%) were the four most common serotypes recovered. Twenty-three (11%) isolates were resistant to at least one antimicrobial, and seven (3.4%) to three or more antimicrobials. Resistance was most often observed to tetracycline (9%), followed by sulfamethoxazole (5%), streptomycin (4%), nalidixic acid (3%), and trimethoprim/sulfamethoxazole (2%). One Salmonella Schwarzengrund isolate recovered from squid imported from Taiwan exhibited resistance to eight antimicrobials, including ampicillin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, sulfamethoxazole, tetracycline, and trimethoprim/sulfamethoxazole. Six isolates (Salmonella Bareilly, Salmonella Derby, Salmonella Ohio and three Salmonella Schwarzengrund) contained class 1 integrons, which carried several resistance genes including dhfrI/dhfrXII, aadA, pse-1, and sat1, conferring resistance to trimethoprim/sulfamethoxazole, streptomycin, ampicillin, and streptothricin, respectively. Five of six nalidixic acid-resistant isolates possessed DNA point mutations at either Ser83 or Asp87 in DNA gyrase. One ciprofloxacin-resistant isolate possessed double mutations in DNA gyrase at positions Ser83 and Asp87 as well as a single mutation at Ser80 in parC. The top three serotypes identified, Salmonella Weltevreden (n = 41), Salmonella Newport (n = 13), and Salmonella Lexington (n = 11), were further characterized for genetic relatedness by pulsed-field gel electrophoresis. Fifty-five distinct pulsed-field gel electrophoresis patterns were observed among the 65 isolates, indicating extensive genetic diversity among these Salmonella serotypes contaminating imported foods. JF - Journal of Food Protection AU - Zhao, S AU - McDERMOTT, P F AU - Friedman, S AU - Qaiyumi, S AU - Abbott, J AU - Kiessling, C AU - Ayers, S AU - Singh, R AU - Hubert, S AU - Sofos, J AU - White, D G AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708 Y1 - 2006 PY - 2006 DA - 2006 SP - 500 EP - 507 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 3 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Agriculture KW - Taiwan KW - Trimethoprim KW - International trade KW - Serotypes KW - Food KW - Quinolones KW - Genetic diversity KW - Kanamycin KW - Streptomycin KW - Tetracyclines KW - DNA topoisomerase IV KW - British Isles, England, Derby KW - Nalidixic acid KW - Streptothricin KW - Chloramphenicol KW - Electrophoresis KW - Sulfamethoxazole KW - Point mutation KW - DNA topoisomerase KW - Ampicillin KW - Food contamination KW - Salmonella weltevreden KW - Antimicrobial agents KW - Gentamicin KW - USA KW - Pulsed-field gel electrophoresis KW - DNA KW - Salmonella KW - Mutation KW - J 02310:Genetics & Taxonomy KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19989499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Characterization+of+Antimicrobial-Resistant+Salmonella+Isolated+from+Imported+Foods&rft.au=Zhao%2C+S%3BMcDERMOTT%2C+P+F%3BFriedman%2C+S%3BQaiyumi%2C+S%3BAbbott%2C+J%3BKiessling%2C+C%3BAyers%2C+S%3BSingh%2C+R%3BHubert%2C+S%3BSofos%2C+J%3BWhite%2C+D+G&rft.aulast=Zhao&rft.aufirst=S&rft.date=2006-01-01&rft.volume=69&rft.issue=3&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Trimethoprim; Chloramphenicol; Serotypes; Sulfamethoxazole; Food; Quinolones; Point mutation; DNA topoisomerase; Ampicillin; Genetic diversity; Kanamycin; Streptomycin; Food contamination; Tetracyclines; DNA topoisomerase IV; Antimicrobial agents; Gentamicin; DNA; Pulsed-field gel electrophoresis; Nalidixic acid; Streptothricin; Agriculture; Electrophoresis; International trade; Mutation; Salmonella; Salmonella weltevreden; USA; Taiwan; British Isles, England, Derby ER - TY - JOUR T1 - beta -Glucans in standardized allergen extracts AN - 19968503; 7048358 AB - Background: Allergen extracts contain variable quantities of bacterial endotoxin. Recent studies have suggested that (1 arrow right 3)- beta -D-glucans ( beta -glucans), also microbial cell wall components, may have adjuvant properties that could affect allergen immunotherapy. Objective: To determine the quantities of beta -glucans in standardized allergen extracts. Materials and Methods: Ninety-four lots of 13 standardized allergen extracts were tested for beta -glucan content by Glucatell assay, and for endotoxin content by a specific, chromogenic formulation of the Limulus amebocyte lysate test. Results: Standardized allergen extracts contain variable quantities of endotoxins and beta -glucans. As in our previous work, endotoxin activity was greatest in cat pelt and Dermatophagoides farinae, and least in the pollens. There was no correlation between endotoxin and beta -glucan levels (r = 0.1887; P = 0.07). beta -Glucan content was highest for grass pollen (median content, 10.6 ng/ml; range, 0.4-41.8 ng/ml), ragweed pollen (32.9 ng/ml; range, 6.5-41.2 ng/ml), and cat pelt (25.5 ng/ml; range, 16.7-41.1 ng/ml), and lowest for cat hair (4.9 ng/ml; range, 1.2-10.3 ng/ml), D. farinae (1.2 ng/ml; range, 0.4-5.2 ng/ml) and Dermatophagoides pteronyssinus (1.8 ng/ml; range, 0.4-6.7 ng/ml). Conclusions: beta -Glucans are present in standardized allergen extracts. The effects of these quantities of beta -glucans on allergen immunotherapy and allergen skin testing require further study. JF - Journal of Endotoxin Research AU - Finkelman, MA AU - Lempitski, S J AU - Slater, JE AD - CBER/FDA (HFM-422), 1401 Rockville Pike, Rockville, MD 20852, USA, jay.slater@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 241 EP - 245 VL - 12 IS - 4 SN - 0968-0519, 0968-0519 KW - House dust mite KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Immunology Abstracts KW - Endotoxins KW - Amebocytes KW - Grasses KW - Immunotherapy KW - Adjuvants KW - Dermatophagoides farinae KW - Hair KW - Pollen KW - Skin tests KW - beta -Glucan KW - Limulus KW - Allergens KW - Dermatophagoides pteronyssinus KW - Cell walls KW - J 02410:Animal Diseases KW - Z 05300:General KW - F 06300:Experimental: Immediate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19968503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=beta+-Glucans+in+standardized+allergen+extracts&rft.au=Finkelman%2C+MA%3BLempitski%2C+S+J%3BSlater%2C+JE&rft.aulast=Finkelman&rft.aufirst=MA&rft.date=2006-01-01&rft.volume=12&rft.issue=4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/10.1179%2F096805106X102237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amebocytes; Endotoxins; beta -Glucan; Grasses; Immunotherapy; Allergens; Adjuvants; Hair; Pollen; Cell walls; Skin tests; Limulus; Dermatophagoides pteronyssinus; Dermatophagoides farinae DO - http://dx.doi.org/10.1179/096805106X102237 ER - TY - JOUR T1 - Research Note: Three-Year Surveillance Program Examining the Prevalence of Campylobacter and Salmonella in Whole Retail Raw Chicken AN - 19964639; 6965306 AB - A 36-month study of Campylobacter and Salmonella in retail raw whole chicken was carried out to measure baseline rates at the retail level, establish seasonality, and observe changes in rates over time. In total, 2,228 samples were taken between November 2001 and December 2004. The Campylobacter rate was unchanged over the 3 years of the study, but the Salmonella rates declined significantly between 2001 and 2004. There was also some seasonality in Campylobacter rates in fresh samples. The overall conclusion from the study was that the Salmonella rate in raw chicken available to consumers in Wales fell significantly between 2001 and 2004, while the Campylobacter rate remained unchanged and is still by far the greater problem. JF - Journal of Food Protection AU - Meldrum, R J AU - Smith, RMM AU - Wilson, I G AD - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK Y1 - 2006 PY - 2006 DA - 2006 SP - 928 EP - 931 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 4 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Poultry KW - Campylobacter KW - Consumers KW - Food contamination KW - Salmonella KW - Seasonal variations KW - British Isles, Wales KW - J 02410:Animal Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Research+Note%3A+Three-Year+Surveillance+Program+Examining+the+Prevalence+of+Campylobacter+and+Salmonella+in+Whole+Retail+Raw+Chicken&rft.au=Meldrum%2C+R+J%3BSmith%2C+RMM%3BWilson%2C+I+G&rft.aulast=Meldrum&rft.aufirst=R&rft.date=2006-01-01&rft.volume=69&rft.issue=4&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Consumers; Seasonal variations; Poultry; Food contamination; Campylobacter; Salmonella; British Isles, Wales ER - TY - JOUR T1 - Detection and Enumeration of Salmonella enteritidis in Homemade Ice Cream Associated with An Outbreak: Comparison of Conventional and Real-Time PCR Methods AN - 19963329; 6965263 AB - Salmonellosis caused by Salmonella Enteritidis (SE) is a significant cause of foodborne illnesses in the United States. Consumption of undercooked eggs and egg-containing products has been the primary risk factor for the disease. The importance of the bacterial enumeration technique has been enormously stressed because of the quantitative risk analysis of SE in shell eggs. Traditional enumeration methods mainly depend on slow and tedious most- probable-number (MPN) methods. Therefore, specific, sensitive, and rapid methods for SE quantitation are needed to collect sufficient data for risk assessment and food safety policy development. We previously developed a real-time quantitative PCR assay for the direct detection and enumeration of SE and, in this study, applied it to naturally contaminated ice cream samples with and without enrichment. The detection limit of the real-time PCR assay was determined with artificially inoculated ice cream. When applied to the direct detection and quantification of SE in ice cream, the real-time PCR assay was as sensitive as the conventional plate count method in frequency of detection. However, populations of SE derived from real-time quantitative PCR were approximately 1 log higher than provided by MPN and CFU values obtained by conventional culture methods. The detection and enumeration of SE in naturally contaminated ice cream can be completed in 3 h by this real-time PCR method, whereas the cultural enrichment method requires 5 to 7 days. A commercial immunoassay for the specific detection of SE was also included in the study. The real-time PCR assay proved to be a valuable tool that may be useful to the food industry in monitoring its processes to improve product quality and safety. JF - Journal of Food Protection AU - Seo, KH AU - Valentin-Bon, I E AU - Brackett, R E AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 639 EP - 643 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 3 SN - 0362-028X, 0362-028X KW - ice cream KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Food KW - Dairy products KW - food-borne diseases KW - Salmonella enteritidis KW - Food-borne diseases KW - Eggs KW - Risk factors KW - Polymerase chain reaction KW - Food quality KW - Quantitation KW - Data processing KW - Food industry KW - outbreaks KW - Food contamination KW - USA KW - Ice cream KW - Salmonellosis KW - Colony-forming cells KW - Outbreaks KW - Shells KW - Immunoassays KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19963329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Detection+and+Enumeration+of+Salmonella+enteritidis+in+Homemade+Ice+Cream+Associated+with+An+Outbreak%3A+Comparison+of+Conventional+and+Real-Time+PCR+Methods&rft.au=Seo%2C+KH%3BValentin-Bon%2C+I+E%3BBrackett%2C+R+E&rft.aulast=Seo&rft.aufirst=KH&rft.date=2006-01-01&rft.volume=69&rft.issue=3&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Food industry; Food; Eggs; Ice cream; Colony-forming cells; Risk factors; Salmonellosis; Polymerase chain reaction; Shells; Food quality; Quantitation; Immunoassays; Dairy products; Outbreaks; outbreaks; Food contamination; food-borne diseases; Food-borne diseases; Salmonella enteritidis; USA ER - TY - JOUR T1 - Evaluation of Magnetic Resonance for Detection of Bacterial Contamination in Low-Acid, Shelf-Stable Packaged Soymilk AN - 19863732; 7313429 AB - This study evaluated magnetic resonance (MR) as a nondestructive method for detection of bacterial contamination in shelf-stable soymilk and cheese sauce. To accomplish this, individual 355-ml polymeric trays filled with soymilk and inoculated with Bacillus stearothermophilus and Bacillus subtilis (10 super(3) CFU) were incubated for up to 28 h at 55 degree C and 62 h at 37 degree C, respectively. MR relaxation times (T sub(2)) of these samples were then correlated with the bacterial growth as well as viscosity and pH changes caused by the bacteria in the packaged soymilk. In addition, this study investigated the ability of MR to differentiate between regularly processed cheese sauce and cheese sauce that was modified with alpha-amylase as a spoilage simulation. Results showed increased MR T sub(2) relaxation times after the bacterial populations reached 10 super(8) CFU/ml (after 18 h) and 10 super(7) CFU/ml (after 44 h) for B. stearothermophilus and B. subtilis, respectively. B. subtilis had an undetectable influence on viscosity but a profound influence on pH. B. stearothermophilus, in comparison, significantly lowered the pH and increased the viscosity of the soymilk. MR was able to distinguish between regularly processed 85-g pouches of cheese sauce and other pouches with sauce that were modified with 0.5 ml of 1% alpha-amylase solution. These results showed that MR has the potential to be used for nondestructive detection of physical changes in soymilk and cheese sauce induced by bacterial growth and enzymatic activities, respectively. JF - Journal of Food Protection AU - Pascall, Melvin A AU - Ravishankar, Sadhana AU - Ghiron, Ken AU - Lee, Bowen T AU - Johannessen, Jan N AD - National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois 60501 Y1 - 2006 PY - 2006 DA - 2006 SP - 1668 EP - 1674 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 7 SN - 0362-028X, 0362-028X KW - soymilk KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Bacteria KW - Bacillus subtilis KW - Milk KW - enzymatic activity KW - Simulation KW - Cheese KW - Food contamination KW - Soybeans KW - Bacillus stearothermophilus KW - Viscosity KW - Spoilage KW - Colony-forming cells KW - Sauces KW - N.M.R. KW - Enzymatic activity KW - pH effects KW - pH KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19863732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Evaluation+of+Magnetic+Resonance+for+Detection+of+Bacterial+Contamination+in+Low-Acid%2C+Shelf-Stable+Packaged+Soymilk&rft.au=Pascall%2C+Melvin+A%3BRavishankar%2C+Sadhana%3BGhiron%2C+Ken%3BLee%2C+Bowen+T%3BJohannessen%2C+Jan+N&rft.aulast=Pascall&rft.aufirst=Melvin&rft.date=2006-01-01&rft.volume=69&rft.issue=7&rft.spage=1668&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Viscosity; Spoilage; Colony-forming cells; N.M.R.; Sauces; Enzymatic activity; Food contamination; Cheese; pH effects; Soybeans; Milk; Simulation; enzymatic activity; pH; Bacillus stearothermophilus; Bacteria; Bacillus subtilis ER - TY - JOUR T1 - Pandemic Influenza Preparedness: Adaptive Responses to an Evolving Challenge AN - 19860703; 7355020 AB - In the United States, preparation for a potential influenza pandemic is receiving heightened media coverage and scrutiny. Scientific attention is focused on the potential for the current Southeastern Asian avian flu virus, Influenza A (H5N1), to become a pandemic threat through genetic mutation and viral reassortment. It Is imperative that we act now, as we face an evolving and advancing disease state with insufficient national preparation. Existing preparedness plans address laboratory and disease surveillance, community containment and border protection, and mass dispensing and vaccination strategies. However, little attention has been directed to identifying and managing psychological and social factors likely to influence human behavior during a pandemic. All of our health and medical strategies require people to behave in prescribed ways to avoid exposure, prevent infection, or halt disease transmission. This article provides timely expert panel recommendations for pandemic influenza response and recovery by addressing human behavior and adaptation. JF - Journal of Homeland Security and Emergency Management AU - Reissman, D B AU - Watson, P J AU - Klomp, R W AU - Tanielian, T L AU - Prior, S D AD - Centers for Disease Control and Prevention, U.S. Public Health Service Y1 - 2006 PY - 2006 DA - 2006 VL - 3 IS - 2 SN - 1547-7355, 1547-7355 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Adaptations KW - disease transmission KW - security KW - Infection KW - Vaccination KW - influenza KW - Disease transmission KW - pandemics KW - Influenza virus KW - Emergency preparedness KW - infection KW - Containment KW - Mutation KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19860703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Homeland+Security+and+Emergency+Management&rft.atitle=Pandemic+Influenza+Preparedness%3A+Adaptive+Responses+to+an+Evolving+Challenge&rft.au=Reissman%2C+D+B%3BWatson%2C+P+J%3BKlomp%2C+R+W%3BTanielian%2C+T+L%3BPrior%2C+S+D&rft.aulast=Reissman&rft.aufirst=D&rft.date=2006-01-01&rft.volume=3&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Homeland+Security+and+Emergency+Management&rft.issn=15477355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - pandemics; Adaptations; Infection; Mutation; Vaccination; Disease transmission; disease transmission; Emergency preparedness; infection; security; Containment; influenza; Influenza virus ER - TY - JOUR T1 - Recovery from botulinum neurotoxin poisoning in vivo AN - 19845972; 6821509 AB - Botulinum neurotoxins cause the disease botulism, which is characterized by prolonged muscle paralysis. In contrast, injections of low doses of purified botulinum neurotoxins do not cause systemic illness but produce localized muscle paralysis that is beneficial for treating several human medical disorders involving uncontrollable muscle contraction. Optimizing the therapeutic efficacy while diminishing adverse reactions requires precise knowledge of toxin potency as well as a clear understanding of how each toxin causes disease. A novel in vivo mouse assay has been used to correlate toxin dosage with the duration of muscle paralysis. Voluntary running activity performed by mice was proportional to the amount of toxin injected into the hind limbs and the subsequent rate of recovery over the ensuing days or weeks was a function of botulinum neurotoxin serotype A or B concentration. Botulinum neurotoxin A produced longer paralysis than botulinum neurotoxin B consistent with human observations. A third serotype, botulinum neurotoxin E, had the shortest duration of action, but unlike the other two toxins, dosage did not influence recovery time. Botulinum neurotoxin A recovery appeared biphasic with the initial phase about two-fold faster than the final phase. Over four weeks, muscle activity had gradually improved following the highest botulinum neurotoxin A dose, reaching about half of the normal running activity. Lower botulinum neurotoxin A doses led to incrementally faster and complete recovery. Persistence of maximum paralysis was exponentially related to botulinum neurotoxin A dosage, with a doubling of the paralysis time occurring with every 25% increase of the toxin concentration. In contrast, the rate of recovery from botulinum neurotoxin B was monophasic relative to toxin dosage and the duration of maximum paralysis was linear relative to dosage. Combinations of botulinum neurotoxin A and B and botulinum neurotoxin A and E were tested and shown to exacerbate paralysis compared with individually administered serotypes. JF - Neuroscience AU - Keller, JE AD - Laboratory of Bacterial Toxins, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, HFM 434, Room 122, Bethesda, MD 20892, USA, james.keller@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 629 EP - 637 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 139 IS - 2 SN - 0306-4522, 0306-4522 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; CSA Neurosciences Abstracts KW - botulism KW - botulinum neurotoxin KW - paralysis KW - recovery KW - potency assay KW - Muscle contraction KW - Serotypes KW - Botulism KW - Running KW - Motor task performance KW - Poisoning KW - Clostridium botulinum KW - Botulinum toxin type A KW - Paralysis KW - Nervous system KW - Limbs KW - Botulinum toxin KW - Side effects KW - J 02410:Animal Diseases KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19845972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Recovery+from+botulinum+neurotoxin+poisoning+in+vivo&rft.au=Keller%2C+JE&rft.aulast=Keller&rft.aufirst=JE&rft.date=2006-01-01&rft.volume=139&rft.issue=2&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2005.12.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Paralysis; Muscle contraction; Nervous system; Limbs; Serotypes; Botulism; Running; Motor task performance; Poisoning; Botulinum toxin type A; Botulinum toxin; Side effects; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.neuroscience.2005.12.029 ER - TY - JOUR T1 - Survival of a Five-Strain Cocktail of escherichia Coli O157:H7 During the 60-Day Aging Period of Cheddar Cheese Made from Unpasteurized Milk AN - 19775134; 6965691 AB - The U.S. Food and Drug Administration Standard of Identity for Cheddar cheeses requires pasteurization of the milk, or as an alternative treatment, a minimum 60-day aging at ge2 degree C for cheeses made from unpasteurized milk, to reduce the number of viable pathogens that may be present to an acceptable risk. The objective of this study was to investigate the adequacy of the 60-day minimum aging to reduce the numbers of viable pathogens and evaluate milk subpasteurization heat treatment as a process to improve the safety of Cheddar cheeses made from unpasteurized milk. Cheddar cheese was made from unpasteurized milk inoculated with 10 super(1) to 10 super(5) CFU/ml of a five-strain cocktail of acid-tolerant Escherichia coli O157:H7. Samples were collected during the cheese manufacturing process. After pressing, the cheese blocks were packaged into plastic bags, vacuum sealed, and aged at 7 degree C. After 1 week, the cheese blocks were cut into smaller-size uniform pieces and then vacuum sealed in clear plastic pouches. Samples were plated and enumerated for E. coli O157:H7. Populations of E. coli O157:H7 increased during the cheese-making operations. Population of E. coli O157:H7 in cheese aged for 60 and 120 days at 7 degree C decreased less than 1 and 2 log, respectively. These studies confirm previous reports that show 60-day aging is inadequate to eliminate E. coli O157:H7 during cheese ripening. Subpasteurization heat-treatment runs were conducted at 148 degree F (64.4 degree C) for 17.5 s on milk inoculated with E. coli O157:H7 at 10 super(5) CFU/ml. These heat-treatment runs resulted in a 5-log E. coli O157: H7 reduction. JF - Journal of Food Protection AU - Schlesser, JE AU - Gerdes, R AU - Ravishankar, S AU - Madsen, K AU - Mowbray, J AU - Teo, AY-L AD - National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Illinois 60501 Y1 - 2006 PY - 2006 DA - 2006 SP - 990 EP - 998 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 5 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Milk KW - Aging KW - Survival KW - Vacuum KW - Pathogens KW - Plasticity KW - Cheese KW - Pasteurization KW - Ripening KW - Cheddar cheese KW - Colony-forming cells KW - Escherichia coli KW - Plastics KW - Heat treatments KW - A 01330:Food Microbiology KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19775134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Survival+of+a+Five-Strain+Cocktail+of+escherichia+Coli+O157%3AH7+During+the+60-Day+Aging+Period+of+Cheddar+Cheese+Made+from+Unpasteurized+Milk&rft.au=Schlesser%2C+JE%3BGerdes%2C+R%3BRavishankar%2C+S%3BMadsen%2C+K%3BMowbray%2C+J%3BTeo%2C+AY-L&rft.aulast=Schlesser&rft.aufirst=JE&rft.date=2006-01-01&rft.volume=69&rft.issue=5&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Milk; Aging; Vacuum; Survival; Pathogens; Cheese; Plasticity; Pasteurization; Ripening; Cheddar cheese; Colony-forming cells; Plastics; Heat treatments; Escherichia coli ER - TY - JOUR T1 - Optimization of Ferrioxamine E Concentration as Effective Supplementation for Selective Isolation of salmonella Enteritidis in Egg White AN - 19774616; 6965262 AB - Utilization of ferrioxamine E (FE) as a sole source of iron distinguishes Salmonella from a number of related species, including Escherichia coli. FE is not able to serve as a source of iron for E. coli or the Proteus- Providencia-Morganella group. This confers a selective advantage on Salmonella Enteritidis in egg white supplemented with FE. The optimum concentration of FE that promoted a selective advantage for Salmonella in egg white was determined. Four supplementation concentrations were evaluated (25, 50, 200, and 500 mu g/ml) in egg white artificially inoculated with proportionally mixed cultures of a rifampin-resistant strain of Salmonella Enteritidis (0.1 ml of 10 super(2) CFU/ml) and E. coli K-12 (0.1 ml of 10 super(1) through 10 super(8) CFU/ml). After a 24-h incubation at 37 degree C, Salmonella and E. coli populations were enumerated. At higher concentrations of FE (>50 mu g/ml), both Salmonella and E. coli were able to use the iron supplement (1 to 8.5 log CFU/ml and 1.8 to 8 log CFU/ml, respectively); however, lower FE concentrations (le50 mu g/ml) exclusively promoted Salmonella growth. Salmonella was unrecoverable without supplementation. This study indicates that optimum levels of FE supplementation in egg can improve the selective detection for Salmonella Enteritidis among other competitive organisms. JF - Journal of Food Protection AU - Thammasuvimol, G AU - Seo, KH AU - Song, KY AU - Holt, P S AU - Brackett, R E AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, Maryland 20740 Y1 - 2006 PY - 2006 DA - 2006 SP - 634 EP - 638 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 3 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Albumen KW - Mixed culture KW - Colony-forming cells KW - Dietary supplements KW - Escherichia coli KW - Ferrioxamine E KW - Iron KW - Salmonella enteritidis KW - Supplementation KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19774616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Optimization+of+Ferrioxamine+E+Concentration+as+Effective+Supplementation+for+Selective+Isolation+of+salmonella+Enteritidis+in+Egg+White&rft.au=Thammasuvimol%2C+G%3BSeo%2C+KH%3BSong%2C+KY%3BHolt%2C+P+S%3BBrackett%2C+R+E&rft.aulast=Thammasuvimol&rft.aufirst=G&rft.date=2006-01-01&rft.volume=69&rft.issue=3&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Albumen; Mixed culture; Dietary supplements; Colony-forming cells; Ferrioxamine E; Iron; Supplementation; Escherichia coli; Salmonella enteritidis ER - TY - JOUR T1 - Multiplex Real-Time PCR Detection of Heat-Labile and Heat- Stable Toxin Genes in Enterotoxigenic Escherichia Coli AN - 19772886; 6965207 AB - A multiplex real-time PCR method was developed for detection of heat-labile and heat-stable toxin genes in enterotoxigenic Escherichia coli. Approximately 10 CFU per reaction mixture could be detected in rinsates from produce samples. Several foods representative of varieties previously shown to have caused enterotoxigenic E. coli outbreaks were spiked and enriched for 4 or 6 h. Both heat-labile and heat-stable toxin genes could be detected in the foods tested, with the exception of hot sauce, with threshold cycle values ranging from 25.2 to 41.1. A procedure using membrane filtration which would allow enumeration of the enterotoxigenic E. coli population in a food sample in less than 28 h by real-time PCR analysis of colonies picked from media highly selective for E. coli was also developed. JF - Journal of Food Protection AU - Grant, Michael A AU - Hu, Jinxin AU - Jinneman, Karen C AD - Pacific Regional Laboratory Northwest, U.S. Food and Drug Administration, 22201 23rd Drive S.E., Bothell, Washington 98021 Y1 - 2006 PY - 2006 DA - 2006 SP - 412 EP - 416 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 69 IS - 2 SN - 0362-028X, 0362-028X KW - Toxicology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Colonies KW - Food KW - Colony-forming cells KW - Escherichia coli KW - Membrane filtration KW - Polymerase chain reaction KW - Sauces KW - Thermal stability KW - Media (selective) KW - Toxins KW - X 24320:Food Additives & Contaminants KW - J 02400:Human Diseases KW - G 07770:Bacteria KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Multiplex+Real-Time+PCR+Detection+of+Heat-Labile+and+Heat-+Stable+Toxin+Genes+in+Enterotoxigenic+Escherichia+Coli&rft.au=Grant%2C+Michael+A%3BHu%2C+Jinxin%3BJinneman%2C+Karen+C&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=69&rft.issue=2&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Colonies; Colony-forming cells; Food; Membrane filtration; Polymerase chain reaction; Sauces; Thermal stability; Media (selective); Toxins; Escherichia coli ER - TY - JOUR T1 - Mechanisms and Biomarkers of Cardiovascular Injury Induced by Phosphodiesterase Inhibitor III SK&F 95654 in the Spontaneously Hypertensive Rat AN - 19726657; 7519949 AB - The cardiovascular injury of the type III selective PDE inhibitor SK&F 95654 was investigated in SHR. Twenty-four hours after a single sc injection of 100 or 200 mg/kg of the drug, rats exhibited cardiomyocyte necrosis and apoptosis, interstitial inflammation, hemorrhage and edema, as well as mesenteric arterial hemorrhage and necrosis, periarteritis, EC and VSMC apoptosis, EC activation, and MC activation and degranulation. Elevated serum levels of cTnT and decreased cTnT immunoperoxidase staining on cardiomyocytes were detected in the drug-treated rats. Serum levels of alpha sub(2)-macroglobulin and IL-6 were significantly elevated following drug treatment. NMR spectral patterns of urine samples are significantly different between the drug-treated and control rats. These results indicate that measurement of serum cTnT, acute phase proteins, and cytokines as well as metabonomic urine profiles may serve as potential biomarkers for drug-induced cardiovascular injury in rats. Increased expression of CD63 on MC (tissue biomarker of MC), of nitrotyrosine on MC and EC (an indirect indicator of NO in vivo), and of iNOS on MC and EC (source of NO) suggest that NO produced by activated and degranulated MC as well as activated EC play an important role in SK&F 95654-induced mesenteric vascular injury. JF - Toxicologic Pathology AU - Zhang, J AU - Herman, E H AU - Robertson, D G AU - Reily, MD AU - Knapton, A AU - Ratajczak, H V AU - Rifai, N AU - Honchel, R AU - Blanchard, K T AU - Stoll, R E AU - Sistare, F D AD - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration. Silver Spring, Maryland. USA Y1 - 2006 PY - 2006 DA - 2006 SP - 152 EP - 163 VL - 34 IS - 2 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Interleukin 6 KW - nitrotyrosine KW - Apoptosis KW - Injuries KW - alpha 2-Macroglobulin KW - Edema KW - CD63 antigen KW - cardiomyocytes KW - Hemorrhage KW - biomarkers KW - Inflammation KW - Serum levels KW - Nitric-oxide synthase KW - Acute phase substances KW - Necrosis KW - Urine KW - Degranulation KW - phosphodiesterase inhibitors KW - Nitric oxide KW - N.M.R. KW - Drugs KW - Vascular system KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19726657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Mechanisms+and+Biomarkers+of+Cardiovascular+Injury+Induced+by+Phosphodiesterase+Inhibitor+III+SK%26amp%3BF+95654+in+the+Spontaneously+Hypertensive+Rat&rft.au=Zhang%2C+J%3BHerman%2C+E+H%3BRobertson%2C+D+G%3BReily%2C+MD%3BKnapton%2C+A%3BRatajczak%2C+H+V%3BRifai%2C+N%3BHonchel%2C+R%3BBlanchard%2C+K+T%3BStoll%2C+R+E%3BSistare%2C+F+D&rft.aulast=Zhang&rft.aufirst=J&rft.date=2006-01-01&rft.volume=34&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230600588562 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Apoptosis; nitrotyrosine; Injuries; alpha 2-Macroglobulin; Edema; CD63 antigen; cardiomyocytes; Hemorrhage; biomarkers; Inflammation; Nitric-oxide synthase; Serum levels; Acute phase substances; Necrosis; Urine; Degranulation; phosphodiesterase inhibitors; N.M.R.; Nitric oxide; Drugs; Vascular system DO - http://dx.doi.org/10.1080/01926230600588562 ER - TY - JOUR T1 - Perceived Discrimination in Health Care Among American Indians/Alaska Natives AN - 19605962; 7312739 AB - Objectives: We compared the prevalence of, and reasons for, perceived discrimination in health care among American Indian/Alaska Natives (AI/ANs) and persons of AI/AN + White heritage to African Americans, Asian Americans, and Whites. Design: Data on perceived discrimination were collected by the 2001 California Health Interview Survey (CHIS). We used chi-square tests to evaluate the prevalence of perceived discrimination and the reasons for perceived discrimination across racial groups. Setting: The 2001 CHIS, a telephone survey, one of the largest cross-sectional surveys ever conducted in the United States. Participants: Participants in this analysis were adults >18 years of age, interviewed from 55,000 households that took part in the survey. Interventions: Participants in the 2001 CHIS were asked 'Thinking of your experiences with receiving health care in the past 12 months, have you felt you were discriminated against for any reason?' Respondents who endorsed this item were asked about possible reasons for the discrimination. Main Outcome Measures: 1) Does the prevalence of perceived discrimination in health care differ between AI/ANs, AI/AN + Whites, African Americans, Asian Americans, and Whites? and 2) Do the reasons for perceived discrimination in health care vary by race or ethnicity? Results: Discrimination was perceived by 7.1% of the AI/AN alone group, 8.8% of AI/AN + White respondents, 5.6% of African Americans, 4.3% of Whites, and 2.6% of Asian Americans. After adjusting for covariates, the odds of perceived discrimination were different for AI/AN + White (odds ratio [OR] = 2.0, 95% confidence interval [CI] 1.5-2.5) and Asian American (OR = .5, 95% CI .4-.7) when compared to Whites. Conclusions: AI/ANs, and especially those who identify as AI/AN + White, were the most likely among racial groups to report discrimination in health care. JF - Ethnicity & Disease AU - Johansson, Patrik AU - Jacobsen, Clemma AU - Buchwald, Dedra AD - Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2006 PY - 2006 DA - 2006 SP - 766 EP - 771 PB - International Society on Hypertension in Blacks, 2045 Manchester St, NE Atlanta GA 30324 USA, [URL:http://www.ishib.org] VL - 16 IS - 4 SN - 1049-510X, 1049-510X KW - Risk Abstracts KW - discrimination KW - Health care KW - Perception KW - INE, USA, California KW - INE, USA, Alaska KW - Ethnic groups KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19605962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Disease&rft.atitle=Perceived+Discrimination+in+Health+Care+Among+American+Indians%2FAlaska+Natives&rft.au=Johansson%2C+Patrik%3BJacobsen%2C+Clemma%3BBuchwald%2C+Dedra&rft.aulast=Johansson&rft.aufirst=Patrik&rft.date=2006-01-01&rft.volume=16&rft.issue=4&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Disease&rft.issn=1049510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - discrimination; Health care; Perception; Ethnic groups; INE, USA, California; INE, USA, Alaska ER - TY - JOUR T1 - H. pylori-infection and antibody immune response in a rural Tanzanian population AN - 19534390; 7247748 AB - Background: Helicobacter pylori (H. pylori) infection is ubiquitous in sub-Saharan Africa, but paradoxically gastric cancer is rare. Methods Sera collected during a household-based survey in rural Tanzania in 1985 were tested for anti-H. pylori IgG and IgG subclass antibodies by enzyme immunoassay. Odds ratios (OR) and confidence intervals (CI) of association of seropositivity with demographic variables were computed by logistic regression models. Results Of 788 participants, 513 were aged =18 years of age. Seropositivity was associated with age (OR 11.5, 95% CI 4.2-31.4 for 10-17 vs. 0-4 years), higher birth-order (11.1; 3.6-34.1 for >=3 super(rd )vs. 1 super(st )born), and having a seropositive next-older sibling (2.7; 0.9-8.3). Median values of IgG subclass were 7.2 for IgG1 and 2.0 for IgG2. The median IgG1/IgG2 ratio was 3.1 (IQR: 1.7-5.6), consistent with a Th2-dominant immune profile. Th2-dominant response was more frequent in children than adults (OR 2.4, 95% CI 1.3-4.4). Conclusion H. pylori seropositivity was highly prevalent in Tanzania and the immunological response was Th2-dominant. Th2-dominant immune response, possibly caused by concurrent bacterial or parasitic infections, could explain, in part, the lower risk of H. pylori-associated gastric cancer in Africa. JF - Infectious Agents and Cancer AU - Mbulaiteye, Sam M AU - Gold, Benjamin D AU - Pfeiffer, Ruth M AU - Brubaker, Glen R AU - Shao, John AU - Biggar, Robert J AU - Hisada, Michie AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA, mbulaits@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1750-9378, 1750-9378 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Article No. 3 KW - Helicobacter pylori KW - Infection KW - Children KW - Models KW - Enzyme immunoassay KW - Demography KW - Risk factors KW - Immunoglobulin G KW - Regression analysis KW - Siblings KW - Immune response KW - Gastric cancer KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19534390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+Agents+and+Cancer&rft.atitle=H.+pylori-infection+and+antibody+immune+response+in+a+rural+Tanzanian+population&rft.au=Mbulaiteye%2C+Sam+M%3BGold%2C+Benjamin+D%3BPfeiffer%2C+Ruth+M%3BBrubaker%2C+Glen+R%3BShao%2C+John%3BBiggar%2C+Robert+J%3BHisada%2C+Michie&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Infectious+Agents+and+Cancer&rft.issn=17509378&rft_id=info:doi/10.1186%2F1750-9378-1-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Demography; Risk factors; Regression analysis; Immunoglobulin G; Siblings; Immune response; Children; Infection; Gastric cancer; Enzyme immunoassay; Models; Helicobacter pylori DO - http://dx.doi.org/10.1186/1750-9378-1-3 ER - TY - JOUR T1 - The influence of tumor oxygenation on super(18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) AN - 19491027; 7181504 AB - Background: This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of super(18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). Results Tumor-bearing mice (squamous cell carcinoma) maintained at 37 degree C were studied while breathing either normal air or carbogen (95% O sub(2), 5% CO sub(2)), known to significantly oxygenate tumors. Tumor activity was measured within an automatically determined volume of interest (VOI). Activity was corrected for the arterial input function as estimated from image and blood-derived data. Tumor FDG uptake was initially evaluated for tumor-bearing animals breathing only air (2 animals) or only carbogen (2 animals). Subsequently, 5 animals were studied using two sequential super(18)F-FDG injections administered to the same tumor-bearing mouse, 60 min apart; the first injection on one gas (air or carbogen) and the second on the other gas. When examining the entire tumor VOI, there was no significant difference of super(18)F- FDG uptake between mice breathing either air or carbogen (i.e. air/carbogen ratio near unity). However, when only the highest super(18)F-FDG uptake regions of the tumor were considered (small VOIs), there was a modest (21%), but significant increase in the air/carbogen ratio suggesting that in these potentially most hypoxic regions of the tumor, super(18)F-FDG uptake and hence glucose metabolism, may be reduced by increasing tumor oxygenation. Conclusion Tumor super(18)F-FDG uptake may be reduced by increases in tumor oxygenation and thus may provide a means to further enhance super(18)F-FDG functional imaging. JF - Radiation Oncology AU - Chan, Linda W AU - Hapdey, Sebastien AU - English, Sean AU - Seidel, Jurgen AU - Carson, Joann AU - Sowers, Anastasia L AU - Krishna, Murali C AU - Green, Michael V AU - Mitchell, James B AU - Bacharach, Stephen L AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, LindaWChan Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1748-717X, 1748-717X KW - Biotechnology and Bioengineering Abstracts KW - Article No. 3 KW - deoxyglucose KW - Blood KW - Radiation KW - Hypoxia KW - Respiration KW - Positron emission tomography KW - Oncology KW - squamous cell carcinoma KW - Glucose metabolism KW - Tumors KW - Carbon dioxide KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Oncology&rft.atitle=The+influence+of+tumor+oxygenation+on+super%2818%29F-FDG+%28Fluorine-18+Deoxyglucose%29+uptake%3A+A+mouse+study+using+positron+emission+tomography+%28PET%29&rft.au=Chan%2C+Linda+W%3BHapdey%2C+Sebastien%3BEnglish%2C+Sean%3BSeidel%2C+Jurgen%3BCarson%2C+Joann%3BSowers%2C+Anastasia+L%3BKrishna%2C+Murali+C%3BGreen%2C+Michael+V%3BMitchell%2C+James+B%3BBacharach%2C+Stephen+L&rft.aulast=Chan&rft.aufirst=Linda&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Radiation+Oncology&rft.issn=1748717X&rft_id=info:doi/10.1186%2F1748-717X-1-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Positron emission tomography; Respiration; Glucose metabolism; deoxyglucose; Carbon dioxide; Blood; Radiation; squamous cell carcinoma; Hypoxia; Oncology DO - http://dx.doi.org/10.1186/1748-717X-1-3 ER - TY - JOUR T1 - Evaluation of functions and tissue compatibility of poly (D,L -lactic-co-glycolic acid) seeded with human dermal fibroblasts AN - 19463451; 7035780 AB - In tissue engineering and wound-healing applications, dermal substitutes are used to provide fibroblasts with the mechanical support for their growth and then to facilitate the skin formation. In this study, three-dimensional porous poly (lactic-co-glycolic acid) (PLGA) 65/35 scaffolds were prepared and then the composites of the scaffolds and human fetal dermal fibroblasts were fabricated as a tissue-engineered dermal substitute. The function and tissue compatibility of the artificial dermal substitute were evaluated at the levels of gene expression (by RT-PCR) and protein expression (total collagen quantities), as well as by histological and immunohistochemical analysis. The PCR products indicated that the mRNA of type-I collagen, mainly secreted by the fibroblasts onto the PLGA scaffolds, was clearly expressed after 4 weeks. The amount of total collagen synthesized from the cells was shown to increase gradually during the initial culture period and slightly decreased afterwards. After 8 weeks of culture, the fibroblasts were well attached and migrated entirely throughout the pores of the PLGA scaffold with normal function. Furthermore, the positively stained type-I collagen was intensively detected throughout the pores. These results suggest that the function and tissue compatibility may be important criteria in evaluating an artificial tissue-engineered skin. JF - Journal of Biomaterials Science. Polymer Edition AU - Yang, W-S AU - Roh, H-W AU - Lee, W K AU - Ryu, G H AD - Department of Medical Devices and Radiation Health, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul, 122-704, South Korea, gyuha@kfda.go.kr Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 151 EP - 162 VL - 17 IS - 1-2 SN - 0920-5063, 0920-5063 KW - Biotechnology and Bioengineering Abstracts KW - Skin KW - polylactide-co-glycolide KW - Wound healing KW - Cell culture KW - Tissue engineering KW - Fetuses KW - scaffolds KW - Collagen KW - Fibroblasts KW - Gene expression KW - Pores KW - Biomaterials KW - Polymerase chain reaction KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomaterials+Science.+Polymer+Edition&rft.atitle=Evaluation+of+functions+and+tissue+compatibility+of+poly+%28D%2CL+-lactic-co-glycolic+acid%29+seeded+with+human+dermal+fibroblasts&rft.au=Yang%2C+W-S%3BRoh%2C+H-W%3BLee%2C+W+K%3BRyu%2C+G+H&rft.aulast=Yang&rft.aufirst=W-S&rft.date=2006-01-01&rft.volume=17&rft.issue=1-2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomaterials+Science.+Polymer+Edition&rft.issn=09205063&rft_id=info:doi/10.1163%2F156856206774879108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Skin; polylactide-co-glycolide; Wound healing; Cell culture; Tissue engineering; scaffolds; Fetuses; Fibroblasts; Collagen; Gene expression; Pores; Biomaterials; Polymerase chain reaction DO - http://dx.doi.org/10.1163/156856206774879108 ER - TY - JOUR T1 - In vitro cytotoxicity of Manville Code 100 glass fibers: Effect of fiber length on human alveolar macrophages AN - 19391210; 7154568 AB - Background Synthetic vitreous fibers (SVFs) are inorganic noncrystalline materials widely used in residential and industrial settings for insulation, filtration, and reinforcement purposes. SVFs conventionally include three major categories: fibrous glass, rock/slag/stone (mineral) wool, and ceramic fibers. Previous in vitro studies from our laboratory demonstrated length-dependent cytotoxic effects of glass fibers on rat alveolar macrophages which were possibly associated with incomplete phagocytosis of fibers >= 17 mu m in length. The purpose of this study was to examine the influence of fiber length on primary human alveolar macrophages, which are larger in diameter than rat macrophages, using length-classified Manville Code 100 glass fibers (8, 10, 16, and 20 mu m). It was hypothesized that complete engulfment of fibers by human alveolar macrophages could decrease fiber cytotoxicity; i.e. shorter fibers that can be completely engulfed might not be as cytotoxic as longer fibers. Human alveolar macrophages, obtained by segmental bronchoalveolar lavage of healthy, non-smoking volunteers, were treated with three different concentrations (determined by fiber number) of the sized fibers in vitro. Cytotoxicity was assessed by monitoring cytosolic lactate dehydrogenase release and loss of function as indicated by a decrease in zymosan-stimulated chemiluminescence. Results Microscopic analysis indicated that human alveolar macrophages completely engulfed glass fibers of the 20 mu m length. All fiber length fractions tested exhibited equal cytotoxicity on a per fiber basis, i.e. increasing lactate dehydrogenase and decreasing chemiluminescence in the same concentration-dependent fashion. Conclusion The data suggest that due to the larger diameter of human alveolar macrophages, compared to rat alveolar macrophages, complete phagocytosis of longer fibers can occur with the human cells. Neither incomplete phagocytosis nor length-dependent toxicity was observed in fiber-exposed human macrophage cultures. In contrast, rat macrophages exhibited both incomplete phagocytosis of long fibers and length- dependent toxicity. The results of the human and rat cell studies suggest that incomplete engulfment may enhance cytotoxicity of fiber glass. However, the possibility should not be ruled out that differences between human versus rat macrophages other than cell diameter could account for differences in fiber effects. JF - Particle and Fibre Toxicology AU - Zeidler-Erdely, Patti C AU - Calhoun, William J AU - Ameredes, Bill T AU - Clark, Melissa P AU - Deye, Gregory J AU - Baron, Paul AU - Jones, William AU - Blake, Terri AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 3 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Article No. 5 KW - Macrophages KW - Cell culture KW - Toxicity KW - Alveoli KW - L-Lactate dehydrogenase KW - Ceramics KW - Wool KW - Fibers KW - Filtration KW - Cytotoxicity KW - Bronchus KW - Chemiluminescence KW - Phagocytosis KW - Minerals KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=In+vitro+cytotoxicity+of+Manville+Code+100+glass+fibers%3A+Effect+of+fiber+length+on+human+alveolar+macrophages&rft.au=Zeidler-Erdely%2C+Patti+C%3BCalhoun%2C+William+J%3BAmeredes%2C+Bill+T%3BClark%2C+Melissa+P%3BDeye%2C+Gregory+J%3BBaron%2C+Paul%3BJones%2C+William%3BBlake%2C+Terri%3BCastranova%2C+Vincent&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2006-01-01&rft.volume=3&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-3-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell culture; Toxicity; Alveoli; L-Lactate dehydrogenase; Wool; Ceramics; Fibers; Cytotoxicity; Filtration; Bronchus; Phagocytosis; Chemiluminescence; Minerals DO - http://dx.doi.org/10.1186/1743-8977-3-5 ER - TY - BOOK T1 - Evaluation of the NAGCAT Tractor Guidelines AN - 19390261; 7157258 JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Fathallah, F A AU - Marlenga, B AU - Pickett, W AU - Miles, JA AU - Meyers, J M AU - Chang, J AU - Plasse, J AU - Miller, B J Y1 - 2006 PY - 2006 DA - 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - tractors KW - Health & Safety Science Abstracts KW - Safety regulations KW - Motor vehicles KW - Occupational safety KW - Working conditions KW - Agricultural equipment KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19390261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fathallah%2C+F+A%3BMarlenga%2C+B%3BPickett%2C+W%3BMiles%2C+JA%3BMeyers%2C+J+M%3BChang%2C+J%3BPlasse%2C+J%3BMiller%2C+B+J&rft.aulast=Fathallah&rft.aufirst=F&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Evaluation+of+the+NAGCAT+Tractor+Guidelines&rft.title=Evaluation+of+the+NAGCAT+Tractor+Guidelines&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 ER - TY - BOOK T1 - Visual Sensor-Based Mobile Equipment Attitude Estimation for Rollover Prevention AN - 19388757; 7157257 JF - NORA SYMPOSIUM 2006: RESEARCH MAKES A DIFFERENCE. AU - Kise, M AU - Zhang, Q Y1 - 2006 PY - 2006 DA - 2006 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Motor vehicles KW - Occupational safety KW - prevention KW - rollover KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kise%2C+M%3BZhang%2C+Q&rft.aulast=Kise&rft.aufirst=M&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Visual+Sensor-Based+Mobile+Equipment+Attitude+Estimation+for+Rollover+Prevention&rft.title=Visual+Sensor-Based+Mobile+Equipment+Attitude+Estimation+for+Rollover+Prevention&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Research to Practice: Efforts to Bring Effective Prevention to Every Community AN - 19282201; 7029519 AB - This manuscript describes the pioneering efforts of the Substance Abuse and Mental Health Services Administration's attempts to catalog knowledge, support, and further evaluate the application of evidence-based prevention. The paper begins with a discussion of scientific inquiry, including discussion of cause-and-effect relationships, theory that is useful in explaining those relationships, and suggestion of the opportunities and limitations of research in these and other areas. The authors then describe a system that has been introduced by the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Substance Abuse Prevention (CSAP) to systematically access and review applied research efforts in drug abuse prevention and related fields. In addition to identifying the key elements of this National Registry of Effective Prevention Programs (NREPP), the authors provide a brief history of prior efforts that have led us to this point. JF - Journal of Primary Prevention AU - Brounstein, Paul J AU - Gardner, Stephen E AU - Backer, Thomas AD - 1 Choke Cherry Road, Room 6-1087, Rockville, MD, 20857, USA, Paul.Brounstein@samhsa.hhs.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 91 EP - 109 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 27 IS - 1 SN - 0278-095X, 0278-095X KW - Risk Abstracts KW - substance abuse KW - drug abuse KW - Historical account KW - Reviews KW - prevention KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19282201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Prevention&rft.atitle=Research+to+Practice%3A+Efforts+to+Bring+Effective+Prevention+to+Every+Community&rft.au=Brounstein%2C+Paul+J%3BGardner%2C+Stephen+E%3BBacker%2C+Thomas&rft.aulast=Brounstein&rft.aufirst=Paul&rft.date=2006-01-01&rft.volume=27&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Prevention&rft.issn=0278095X&rft_id=info:doi/10.1007%2Fs10935-005-0024-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - substance abuse; Historical account; drug abuse; Reviews; prevention DO - http://dx.doi.org/10.1007/s10935-005-0024-6 ER - TY - JOUR T1 - Population distribution of the functional caspase-12 allele AN - 19275422; 7014899 AB - Members of the caspase family can be important for apoptosis or inflammation, but the role of caspase-12 (CASP12 or CSP12) is unclear. Although most humans lack a functional caspase-12, the Csp 12-L variant, previously found only among people of African descent, produces a full-length proenzyme and increases the risk of sepsis. In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations from sub-Saharan Africa and was also present at low frequency among North African, Middle Eastern, and South Asian populations. Published 2006 Wiley-Liss, Inc. JF - Human Mutation AU - Kachapati, Kritika AU - O'Brien, Thomas R AU - Bergeron, Julie AU - Zhang, Mingdong AU - Dean, Michael AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, obrient@exchange.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 975 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 27 IS - 9 SN - 1059-7794, 1059-7794 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - caspase-12 KW - CASP12 KW - infection KW - sepsis KW - Population genetics KW - Sepsis KW - Apoptosis KW - Caspase-12 KW - Gene frequency KW - Proenzymes KW - Inflammation KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19275422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Mutation&rft.atitle=Population+distribution+of+the+functional+caspase-12+allele&rft.au=Kachapati%2C+Kritika%3BO%27Brien%2C+Thomas+R%3BBergeron%2C+Julie%3BZhang%2C+Mingdong%3BDean%2C+Michael&rft.aulast=Kachapati&rft.aufirst=Kritika&rft.date=2006-01-01&rft.volume=27&rft.issue=9&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Human+Mutation&rft.issn=10597794&rft_id=info:doi/10.1002%2Fhumu.9448 L2 - http://www3.interscience.wiley.com/homepages/38515/pdf/919.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Population genetics; Sepsis; Apoptosis; Caspase-12; Gene frequency; Proenzymes; Inflammation DO - http://dx.doi.org/10.1002/humu.9448 ER - TY - JOUR T1 - Thromboembolic Adverse Events After Use of Recombinant Human Coagulation Factor VIIa AN - 17475065; 6663712 AB - CONTEXT: The US Food and Drug Administration (FDA) licensed recombinant human coagulation factor VIIa (rFVIIa) on March 25, 1999, for bleeding in patients with hemophilia A or B and inhibitors to factors VIII or IX. Use in patients without hemophilia has been increasing since licensure. OBJECTIVE: To review serious thromboembolic adverse events (AEs) reported to the FDA's Adverse Event Reporting System (AERS). DESIGN, SETTING, AND PATIENTS: The AERS database was reviewed from March 25, 1999, through December 31, 2004, for thromboembolic AE reports with rFVIIa. The AERS database includes US and non-US spontaneous AE reports from both approved (specific indications for patients with hemophilia) and unlabeled uses. It also includes serious AEs in patients enrolled in postlicensure clinical trials who received rFVIIa. Manufacturer reporting to FDA is mandatory, but primary notification from clinicians and others to FDA or manufacturers is voluntary for spontaneous reports; therefore, AERS underrepresents actual event occurrences. MAIN OUTCOME MEASURE: Reported thromboembolic events occurring in patients administered rFVIIa. RESULTS: A total of 431 AE reports for rFVIIa were found, of which 168 reports described 185 thromboembolic events. Seventeen events occurred in patients with hemophilia and 59 occurred in patients enrolled in postlicensure trials. Unlabeled indications accounted for 151 of the reports, most with active bleeding (n = 115). Reported AEs were thromboembolic cerebrovascular accident (n = 39), acute myocardial infarction (n = 34), other arterial thromboses (n = 26), pulmonary embolism (n = 32), other venous thromboses (including deep vein thrombosis) (n = 42), and clotted devices (n = 10). In 36 (72%) of 50 reported deaths, the probable cause of death was the thromboembolic event. In 144 patients with timing information, 73 events (52%) occurred in the first 24 hours after the last dose (30 events within 2 hours). Sixty-four reports (38%) noted concomitant use of hemostatic agents. Most reports lacked sufficient information to evaluate potential dosage associations. CONCLUSIONS: Most reported thromboembolic AEs followed the use of rFVIIa for unlabeled indications and occurred in arterial and venous systems, often resulting in serious morbidity and mortality. Analysis of the relationship between AEs and rFVIIa is hindered by concomitant medications, preexisting medical conditions, confounding by indication, and inherent limitations of passive surveillance. Randomized controlled trials are needed to establish the safety and efficacy of rFVIIa in patients without hemophilia. JF - JAMA: Journal of the American Medical Association AU - O'Connell, Kathryn A AU - Wood, Jennifer J AU - Wise, Robert P AU - Lozier, Jay N AU - Braun, MMiles AD - Division of Epidemiology, Office of Biostatistics and Epidemiology (Drs O'Connell, Wood, Wise, and Braun), and Division of Hematology, Office of Blood Research and Review (Dr Lozier), Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 293 EP - 298 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 295 IS - 3 SN - 0098-7484, 0098-7484 KW - licensed recombinant human coagulation factor KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Mortality KW - Stroke KW - Coagulation factors KW - Coagulation factor VIIa KW - Clinical trials KW - Myocardial infarction KW - Thromboembolism KW - Thrombosis KW - Hemophilia KW - Databases KW - Veins KW - Lung KW - FDA KW - Bleeding KW - Drugs KW - Side effects KW - H 4000:Food and Drugs KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17475065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Thromboembolic+Adverse+Events+After+Use+of+Recombinant+Human+Coagulation+Factor+VIIa&rft.au=O%27Connell%2C+Kathryn+A%3BWood%2C+Jennifer+J%3BWise%2C+Robert+P%3BLozier%2C+Jay+N%3BBraun%2C+MMiles&rft.aulast=O%27Connell&rft.aufirst=Kathryn&rft.date=2006-01-01&rft.volume=295&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Databases; Veins; Lung; Stroke; Coagulation factors; Bleeding; Coagulation factor VIIa; Clinical trials; Thrombosis; Thromboembolism; Myocardial infarction; Hemophilia; Mortality; FDA; Drugs; Side effects ER - TY - JOUR T1 - Primary Reinforcing Effects of Nicotine Are Triggered from Multiple Regions Both Inside and Outside the Ventral Tegmental Area AN - 17467189; 6664526 AB - Nicotine is thought to be the key substance responsible for tobacco-smoking habits and appears to trigger reinforcement via the ventral tegmental area (VTA). Recently, multiple anatomical substrates for drug reinforcement have been identified in the vicinity of the ventral midbrain. In addition to the posterior portion of the VTA, the central linear nucleus raphe and the supramammillary nucleus of the posterior hypothalamus mediate drug reinforcement. Using intracranial self-administration procedures, we examined whether these regions mediate the reinforcing effects of nicotine. Rats learned to lever press for self-administration of nicotine into the posterior VTA, central linear nucleus, and supramammillary nucleus, suggesting a reinforcing action of nicotine in these regions. The rats did not self-administer nicotine into surrounding regions including the anterior VTA, substantia nigra, the region just dorsal to the posterior VTA, interpeduncular nucleus, or medial mammillary nucleus. The reinforcing effects of nicotine into the three brain regions were further confirmed by a two-lever discrimination procedure, in which rats learned to selectively respond between active and inactive levers. The reinforcing effects of nicotine administration into the posterior VTA, central linear nucleus, and supramammillary nucleus were blocked by coadministration of the nicotine receptor antagonist mecamylamine. The reinforcing effects of nicotine into the posterior VTA or central linear nucleus were attenuated by coadministration of the D sub(2) receptor agonist quinpirole. These findings demonstrate that nicotine reinforcement involves multiple regions both inside and outside the VTA. JF - Journal of Neuroscience AU - Ikemoto, Satoshi AU - Qin, Mei AU - Liu, Zhong-Hua AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 723 EP - 730 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 3 SN - 0270-6474, 0270-6474 KW - rats KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Dopamine D2 receptors KW - Intracranial self-stimulation KW - Hypothalamus KW - Nicotine KW - mecamylamine KW - Ventral tegmentum KW - Intracranial reinforcement KW - Drug self-administration KW - Y 25807:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Primary+Reinforcing+Effects+of+Nicotine+Are+Triggered+from+Multiple+Regions+Both+Inside+and+Outside+the+Ventral+Tegmental+Area&rft.au=Ikemoto%2C+Satoshi%3BQin%2C+Mei%3BLiu%2C+Zhong-Hua&rft.aulast=Ikemoto&rft.aufirst=Satoshi&rft.date=2006-01-01&rft.volume=26&rft.issue=3&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Intracranial self-stimulation; Hypothalamus; mecamylamine; Nicotine; Ventral tegmentum; Drug self-administration; Intracranial reinforcement ER - TY - JOUR T1 - Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK-53 virus by sequencing and quantitative TaqMAMA AN - 17459850; 6638409 AB - The genetic stabilities of the three attenuation loci of the candidate dengue 2 (D2) PDK-53 vaccine virus were evaluated for the PDK-53 virus and PDK-53-vectored chimeric D2/1, D2/3, and D2/4 viruses following 10 sequential passages in Vero cells. Sequencing revealed that the dominant NS1-53-Asp and the NS3-250-Val attenuation loci were extremely stable, whereas reversion occurred at the 5'NCR-57-U locus in 10 of the 18 viral lineages tested. A more sensitive and quantitative assay, the TaqMan mismatch amplification mutation assay (TaqMAMA), was employed to more finely discriminate the level of reversion at the 5'NCR-57 locus. This rapid genetic assay permitted detection of approximately equal to 1% reversion of 5'NCR-57 U-to-C in viral populations. By TaqMAMA, various levels of reversion at 5'NCR-57 were detected in all 18 of the PDK-53-based viral lineages tested at Vero passage 10, but only 3 lineages had reversion levels >80% in the viral population. Chimeric viruses based on the PDK-53-V (all three mutations present) genetic background were more stable than those developed in the PDK-53-E (5'NCR and NS1 mutations present) background. The TaqMAMA can be applied in quality control analyses to ensure that attenuated vaccine seeds contain undetectable or minimal levels of reversion at a given attenuation locus. JF - Journal of Virological Methods AU - Butrapet, S AU - Kinney, R M AU - Huang, CYH AD - Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA, CHuang1@cdc.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1 EP - 9 VL - 131 IS - 1 SN - 0166-0934, 0166-0934 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Dengue virus KW - Seeds KW - Vero cells KW - Dengue KW - Quality control KW - Reversion KW - Attenuation KW - Vaccines KW - Mutation KW - W3 33365:Vaccines (other) KW - V 22050:Viral genetics including virus reactivation KW - V 22097:Immunization: Vaccines & vaccination: Human KW - G 07800:Plants and Algae KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17459850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Determining+genetic+stabilities+of+chimeric+dengue+vaccine+candidates+based+on+dengue+2+PDK-53+virus+by+sequencing+and+quantitative+TaqMAMA&rft.au=Butrapet%2C+S%3BKinney%2C+R+M%3BHuang%2C+CYH&rft.aulast=Butrapet&rft.aufirst=S&rft.date=2006-01-01&rft.volume=131&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2005.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Seeds; Vero cells; Dengue; Quality control; Attenuation; Reversion; Vaccines; Mutation; Dengue virus DO - http://dx.doi.org/10.1016/j.jviromet.2005.06.019 ER - TY - JOUR T1 - A PE Protein Expressed by Mycobacterium avium Is an Effective T-Cell Immunogen AN - 17439927; 6576979 AB - Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes. JF - Infection and Immunity AU - Parra, Marcela AU - Cadieux, Nathalie AU - Pickett, Thames AU - Dheenadhayalan, Veerabadran AU - Brennan, Michael J AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 786 EP - 789 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - PE protein KW - mice KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Aerosols KW - Mycobacterium avium KW - DNA vaccines KW - Lymphocytes T KW - Immune response KW - Infection KW - Immunization KW - Epitopes KW - Mycobacterium tuberculosis KW - J 02832:Antigenic properties and virulence KW - F 06100:Vaccines - active immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17439927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=A+PE+Protein+Expressed+by+Mycobacterium+avium+Is+an+Effective+T-Cell+Immunogen&rft.au=Parra%2C+Marcela%3BCadieux%2C+Nathalie%3BPickett%2C+Thames%3BDheenadhayalan%2C+Veerabadran%3BBrennan%2C+Michael+J&rft.aulast=Parra&rft.aufirst=Marcela&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Aerosols; DNA vaccines; Lymphocytes T; Immune response; Infection; Epitopes; Immunization; Mycobacterium avium; Mycobacterium tuberculosis ER - TY - JOUR T1 - Adolescent Nicotine Metabolism: Ethnoracial Differences Among Dependent Smokers AN - 17256537; 6964449 AB - Variations in nicotine metabolism are thought to contribute to differences in cigarette consumption between African Americans and Caucasian adult smokers. To investigate the potential mechanism of previously documented lower smoking rates among African-American adolescent smokers seeking cessation treatment, we measured nicotine metabolite ratios as markers of the metabolic disposition of nicotine, which is generally considered to be under the influence of cytochrome P450 (CYP) 2A6. Plasma ratios of trans-3'-hydroxycotinine (3HC) to cotinine (COT) were examined in 92 cessation treatment-seeking adolescents (mean age 15.2 years, standard deviation [SD] 1.3, 69% female, 31% African American, mean Fagerstroem Test for Nicotine Dependence [FTND] 6.5, SD 1.6, mean years smoked 2.6, SD 1.6). Groups were similar in age, gender distribution, and mean FTND score. Analysis with independent t tests revealed significantly lower number of cigarettes per day (CPD) (15.1, SD 7.6 vs 19.6, SD 8.0, P=.013) and nicotine metabolite ratios (0.27, SD 0.15 vs 0.35, SD 0.16, P=.026) in African-American compared to Caucasian adolescent smokers. Consistent with metabolic variation, mean COT/CPD ratio was significantly higher in African- American compared to Caucasian adolescents. Results remained statistically significant when comparing menthol smokers by ethnicity. These findings are consistent with those found among adult smokers and provide a putative mechanism for reported ethnoracial differences in adolescent cigarette consumption. Our results underscore the need for measures independent of consumption for determining degree of nicotine dependence and treatment selection across ethnicities, even among youths. JF - Ethnicity & Disease AU - Moolchan, Eric T AU - Franken, Frederick H AU - Jaszyna-Gasior, Maria AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland Y1 - 2006 PY - 2006 DA - 2006 SP - 239 EP - 243 PB - International Society on Hypertension in Blacks, 2045 Manchester St, NE Atlanta GA 30324 USA, [URL:http://www.ishib.org] VL - 16 IS - 1 SN - 1049-510X, 1049-510X KW - Physical Education Index KW - Measurement KW - Statistics KW - Blacks KW - Adolescence KW - Adults KW - Smoking KW - Analysis KW - Gender KW - Tobacco KW - Diseases KW - Metabolism KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17256537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Disease&rft.atitle=Adolescent+Nicotine+Metabolism%3A+Ethnoracial+Differences+Among+Dependent+Smokers&rft.au=Moolchan%2C+Eric+T%3BFranken%2C+Frederick+H%3BJaszyna-Gasior%2C+Maria&rft.aulast=Moolchan&rft.aufirst=Eric&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Disease&rft.issn=1049510X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoking; Measurement; Statistics; Blacks; Analysis; Adolescence; Gender; Tobacco; Diseases; Adults; Youth; Metabolism ER - TY - JOUR T1 - Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women AN - 17240213; 6986205 AB - Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathione- S-transferase M1 (GSTM1) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptibility to lung cancer. A case-only design was used with lung cancer cases pooled from 3 previously completed case-control studies using archival tissue samples from 270 lung cancer cases to genotype GSTM1. Radon concentrations were measured with long-term [alpha]-track radon detectors. Secondhand smoke (SHS) was measured with questionnaires and interviews. Unconditional logistic regression was used to calculate the interaction odds ratios (OR) and 95% confidence intervals (95% CI). Radon concentrations >121 Bq m super(-3) were associated with a >3-fold interaction OR (OR = 3.41; 95% CI = 1.10, 10.61) for GSTM1 null homozygotes compared to GSTM1 carriers; the linear trend was significant (p trend = 0.03). The SHS and GSTM1 interaction OR was also elevated (OR = 2.28; 95% CI = 1.15-4.51) among never-smokers. This may be the first study to provide evidence of a GSTM1 and radon interaction in risk of lung cancer. Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway. JF - International Journal of Cancer AU - Bonner, Matthew R AU - Bennett, William P AU - Xiong, Wenying AU - Lan, Qing AU - Brownson, Ross C AU - Harris, Curtis C AU - Field, RWilliam AU - Lubin, Jay H AU - Alavanja, Michael CR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, MD, mrbonner@buffalo.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 1462 EP - 1467 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 6 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts KW - radon KW - secondhand smoke KW - glutathione-S-transferase KW - lung cancer KW - epidemiology KW - Inventories KW - Genotypes KW - Glutathione transferase KW - Neoplasia KW - Homozygotes KW - Radon KW - Smoke KW - GSTM1 protein KW - Passive smoking KW - Reactive oxygen species KW - Oxidative stress KW - Ionizing radiation KW - Tobacco KW - Females KW - Lung cancer KW - X 24390:Radioactive Materials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17240213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Radon%2C+secondhand+smoke%2C+glutathione-S-transferase+M1+and+lung+cancer+among+women&rft.au=Bonner%2C+Matthew+R%3BBennett%2C+William+P%3BXiong%2C+Wenying%3BLan%2C+Qing%3BBrownson%2C+Ross+C%3BHarris%2C+Curtis+C%3BField%2C+RWilliam%3BLubin%2C+Jay+H%3BAlavanja%2C+Michael+CR&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2006-01-01&rft.volume=119&rft.issue=6&rft.spage=1462&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Genotypes; Glutathione transferase; Radon; Homozygotes; Neoplasia; Smoke; GSTM1 protein; Reactive oxygen species; Oxidative stress; Ionizing radiation; Tobacco; Lung cancer; Passive smoking; Females DO - http://dx.doi.org/10.1002/ijc.22002 ER - TY - JOUR T1 - Effects of aminopentol on in utero development in rats AN - 17227537; 6932861 AB - Aminopentol (AP1), the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), is present in corn-based foods which are consumed daily as a substantial part of the diet in some areas of the world. The toxicity of FB1 has been attributed to altered sphingolipid metabolism, but the toxicity of AP1 is less certain. Epidemiological correlations and in vitro studies have suggested that AP1 can increase neural tube defects (NTDs), but no in vivo developmental study of AP1 was done prior to this study. AP1 was given once daily to rats by gavage on gestation days (GD) 3-16 at doses of 0, 15, 30, 60, or 120 mg/kg. Reproductive and developmental parameters were measured at GD 17, one day after the last dose, and on GD 20. In addition, on GD 17, maternal and fetal tissues were analyzed for sphingolipid content. Conclusions: AP1 reduced dam body weight gain, but was less toxic than FB1. AP1 was not teratogenic, did not affect tissue sphingolipid ratios, did not alter reproduction or development of fetuses, and produced no dose-related histopathological effects in dams. JF - Food and Chemical Toxicology AU - Collins, Thomas FX AU - Sprando, Robert L AU - Black, Thomas N AU - Olejnik, Nicholas AU - Eppley, Robert M AU - Shackelford, Mary E AU - Howard, Paul C AU - Rorie, James I AU - Bryant, Mark AU - Ruggles, Dennis I AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA, tcollins@cfsan.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 161 EP - 169 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 2 SN - 0278-6915, 0278-6915 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts KW - Aminopentol KW - Hydrolyzed fumonisin B1 KW - Developmental toxicity KW - Diets KW - Food KW - Toxicity KW - Hydrolysis KW - Neural tube defects KW - Fetuses KW - Lipid metabolism KW - Mycotoxins KW - Sphingolipids KW - Gestation KW - Fumonisin B1 KW - Reproduction KW - Teratogenicity KW - Body weight gain KW - Metabolism KW - X 24120:Food, additives & contaminants KW - X 24171:Microbial KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17227537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+aminopentol+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BShackelford%2C+Mary+E%3BHoward%2C+Paul+C%3BRorie%2C+James+I%3BBryant%2C+Mark%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-01-01&rft.volume=44&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2005.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Food; Toxicity; Hydrolysis; Fetuses; Neural tube defects; Lipid metabolism; Mycotoxins; Sphingolipids; Gestation; Teratogenicity; Reproduction; Fumonisin B1; Body weight gain; Metabolism DO - http://dx.doi.org/10.1016/j.fct.2005.06.009 ER - TY - JOUR T1 - Allergen sequence databases AN - 17224820; 6933586 AB - A number of specialized databases have been developed to facilitate studies of human allergens. These include molecular databases focused on protein sequences and structures, informational databases focused on clinical, biochemical and epidemiological data related to protein allergens, a database on allergen nomenclature, and other knowledge bases or informational websites that are peripherally-related to research on allergens. Examples of each type of databases are listed and described briefly in this review. Database construction and maintenance and their impact on database quality and usefulness are also discussed. JF - Molecular Nutrition & Food Research AU - Gendel, Steven M AU - Jenkins, John A AD - Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois, USA., sgendel@cfsan.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 633 EP - 637 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 50 IS - 7 SN - 1613-4125, 1613-4125 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Databases KW - Reviews KW - Allergens KW - W4 330:Biopolymers & Food Biotechnology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17224820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Nutrition+%26+Food+Research&rft.atitle=Allergen+sequence+databases&rft.au=Gendel%2C+Steven+M%3BJenkins%2C+John+A&rft.aulast=Gendel&rft.aufirst=Steven&rft.date=2006-01-01&rft.volume=50&rft.issue=7&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Molecular+Nutrition+%26+Food+Research&rft.issn=16134125&rft_id=info:doi/10.1002%2Fmnfr.200500271 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Allergens; Reviews DO - http://dx.doi.org/10.1002/mnfr.200500271 ER - TY - JOUR T1 - An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera AN - 17168735; 6843400 AB - Aloe barbadensis (Miller), Aloe vera, has a long history of use as a topical and oral therapeutic. The plant is the source of two products, gel and latex, which are obtained from its fleshy leaves. Aloe vera products contain multiple constituents with potential biological and toxicological activities, yet the active components elude definition. Ingestion of Aloe vera is associated with diarrhea, electrolyte imbalance, kidney dysfunction, and conventional drug interactions; episodes of contact dermatitis, erythema, and phototoxicity have been reported from topical applications. This review examines the botany, physical and chemical properties, and biological activities of the Aloe vera plant. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Boudreau, MD AU - Beland, F A AD - National center for Toxicological Research, Jefferson, Arkansas, USA, mary.boudreau@fda.hhs.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 103 EP - 154 VL - 24 IS - 1 SN - 1059-0501, 1059-0501 KW - Toxicology Abstracts KW - Drug interaction KW - Erythema KW - Contact dermatitis KW - Diarrhea KW - Leaves KW - Latex KW - Topical application KW - Phototoxicity KW - Aloe barbadensis KW - Aloe vera KW - Renal function KW - Reviews KW - Carcinogenesis KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=An+Evaluation+of+the+Biological+and+Toxicological+Properties+of+Aloe+Barbadensis+%28Miller%29%2C+Aloe+Vera&rft.au=Boudreau%2C+MD%3BBeland%2C+F+A&rft.aulast=Boudreau&rft.aufirst=MD&rft.date=2006-01-01&rft.volume=24&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590500600614303 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phototoxicity; Drug interaction; Erythema; Diarrhea; Contact dermatitis; Renal function; Reviews; Carcinogenesis; Leaves; Latex; Topical application; Aloe vera; Aloe barbadensis DO - http://dx.doi.org/10.1080/10590500600614303 ER - TY - JOUR T1 - Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E sub(2) and C-reactive protein in serum and livers of pregnant and non-pregnant female rats AN - 17157993; 6820772 AB - Androstenedione, a steroidal dietary supplement taken to enhance athletic performance, could affect serum and liver lipid metabolism, induce liver toxicity or alter inflammatory response depending on dose and duration of exposure. Pregnancy could further exaggerate these effects. To examine this, mature female rats were gavaged with 0, 5, 30 or 60 mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60 mg/kg/day androstenedione. Serum was collected and livers were removed from dams on gestation day 20 and from non-pregnant rats after 5 weeks of treatment. Androstenedione had no effect on serum total cholesterol, triglycerides or HDL- cholesterol, but significantly decreased C-reactive protein in pregnant rats and prostaglandin E sub(2) in serum of both pregnant and non-pregnant rats. There were treatment related decreases in liver ATP and, to a lesser degree, caspase-3 and no change in alkaline phosphatase of pregnant female rats. Androstenedione decreased docosahexaenoic acid in both serum and liver phospholipids of pregnant female rats. In conclusion, oral androstenedione did not result in overt hepatotoxicity in pregnant female rats, but produced modest changes in lipid metabolism and may impair regeneration of injured hepatic cells or tissue. JF - Food and Chemical Toxicology AU - Wiesenfeld, P W AU - Sapienza, P P AU - Flynn, T J AU - Ford, CE AU - Ross, IA AU - Sahu, S AU - Kim, C S AU - O'Donnell, M W AU - Collins, TFX AU - Sprando, R L AD - US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA, pwiesenf@cfsan.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 579 EP - 587 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 4 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Androstenedione KW - Pregnant KW - Rats KW - Liver KW - Fatty acids KW - C-reactive protein KW - Prostaglandin E sub(2) KW - Prostaglandin E2 KW - Cholesterol KW - Dietary intake KW - Lipid metabolism KW - Pregnancy KW - Docosahexaenoic acid KW - Gestation KW - Caspase-3 KW - Phospholipids KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17157993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+oral+androstenedione+on+phospholipid+fatty+acids%2C+ATP%2C+caspase-3%2C+prostaglandin+E+sub%282%29+and+C-reactive+protein+in+serum+and+livers+of+pregnant+and+non-pregnant+female+rats&rft.au=Wiesenfeld%2C+P+W%3BSapienza%2C+P+P%3BFlynn%2C+T+J%3BFord%2C+CE%3BRoss%2C+IA%3BSahu%2C+S%3BKim%2C+C+S%3BO%27Donnell%2C+M+W%3BCollins%2C+TFX%3BSprando%2C+R+L&rft.aulast=Wiesenfeld&rft.aufirst=P&rft.date=2006-01-01&rft.volume=44&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2005.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Androstenedione; Docosahexaenoic acid; Gestation; Caspase-3; Liver; Cholesterol; Prostaglandin E2; Dietary intake; Pregnancy; Lipid metabolism; C-reactive protein; Phospholipids DO - http://dx.doi.org/10.1016/j.fct.2005.09.005 ER - TY - JOUR T1 - Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats AN - 17157378; 6816367 AB - Deoxynivalenol (DON, vomitoxin), is one of the most common contaminants of cereal grains world-wide. The effects of DON on fetal development were assessed in Charles River Sprague-Dawley rats. Pregnant female rats were gavaged once daily with DON at doses of 0, 0.5, 1, 2.5, or 5 mg/kg body weight on gestation days (GD) 6-19. At cesarean section on GD 20, reproductive and developmental parameters were measured. All females survived to cesarean section. DON caused a dose-related increase in excessive salivation by the pregnant females, a reaction probably linked to the lack of emetic reflex in rats. At 5 mg/kg, feed consumption and mean body weight gain were significantly decreased throughout gestation, mean weight gain (carcass weight), and gravid uterine weight were significantly reduced, 52% of litters (12/23) were totally resorbed, the average number of early and late deaths per litter was significantly increased, average fetal body weight and crown-rump length were significantly decreased, the incidence of runts was significantly increased, and the ossification of fetal sternebrae, centra, dorsal arches, vertebrae, metatarsals, and metacarpals was significantly decreased. At 2.5 mg/kg, DON significantly decreased average fetal body weight, crown-rump length, and vertebral ossification. These effects may be secondary to maternal toxicity and the reduced size of the fetuses. The incidence of misaligned and fused sternebrae was significantly increased at 5.0 mg/kg. No adverse developmental effects were observed at 0.5 and 1.0 mg/kg. Dose-related increases in maternal liver weight-to-body weight ratios were observed in all treated groups (significant at 1, 2.5, and 5 mg/kg). The weight changes were correlated with dose-related cytoplasmic alterations of hepatocytes. The NOEL for maternal toxicity for this study is 0.5 mg/kg based on the dose-related increase in liver-body weight ratio at 1 mg/kg. The NOEL for fetal toxicity is 1 mg/kg based on the general reduction in fetal development at 2.5 and 5 mg/kg. DON is considered a teratogen at 5 mg/kg day in Sprague-Dawley rats based on the anomalous development of the sternebrae. JF - Food and Chemical Toxicology AU - Collins, Thomas FX AU - Sprando, Robert L AU - Black, Thomas N AU - Olejnik, Nicholas AU - Eppley, Robert M AU - Hines, Fred A AU - Rorie, James AU - Ruggles, Dennis I AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA, tcollins@cfsan.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 747 EP - 757 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 44 IS - 6 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Deoxynivalenol KW - Vomitoxin KW - Trichothecene mycotoxin KW - Developmental toxicity KW - Rat KW - Emetics KW - Uterus KW - Spine KW - Ossification KW - Hepatocytes KW - Gestation KW - Cesarean section KW - Teratogens KW - Fetuses KW - Vertebrae KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17157378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+deoxynivalenol+%28DON%2C+vomitoxin%29+on+in+utero+development+in+rats&rft.au=Collins%2C+Thomas+FX%3BSprando%2C+Robert+L%3BBlack%2C+Thomas+N%3BOlejnik%2C+Nicholas%3BEppley%2C+Robert+M%3BHines%2C+Fred+A%3BRorie%2C+James%3BRuggles%2C+Dennis+I&rft.aulast=Collins&rft.aufirst=Thomas&rft.date=2006-01-01&rft.volume=44&rft.issue=6&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2005.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Emetics; Uterus; Spine; Vomitoxin; Ossification; Hepatocytes; Gestation; Cesarean section; Teratogens; Vertebrae; Fetuses DO - http://dx.doi.org/10.1016/j.fct.2005.10.007 ER - TY - JOUR T1 - Toxicogenomics and Cross-Species Biomarker Discovery: Applications in Drug Discovery and Safely Assessment AN - 17142121; 6757574 AB - Toxicogenomics has evolved into a useful technique for providing greater mechanistic insights into adverse effects that will spur the development of novel approaches for identifying and understanding toxicity issues. The ability to capture a snapshot of the transcriptome at any given time during the development of an adverse phenotype allows unprecedented molecular views into the dynamic physiological changes that are occurring on either time or dose continuum for a toxicology study of interest advancing our basic knowledge of adverse events, and providing the necessary scientific framework for developing new strategies and tools for safety assessment programs. The development of an effective subset of cost effective devices for identifying toxicity earlier in the drug development process will help identify the most promising candidate compounds to move forward leading to a reduction in compound attrition due to toxicity. In addition, there is a need in the pharmaceutical industry to develop safety and efficacy biomarkers that are relevant to multiple species such as rat, dog, and human. Genomics provides an opportunity to discover novel cross-species biomarkers for identifying phenotypes such as liver fibrosis, especially if the biomarkers are tissue specific secreted proteins that can be monitored in the serum. This review includes an example of how databases from multiple species, in this case rat and human tissues, can be utilized to identify candidate cross-species diagnostic markers of hepatitis and fibrosis. This study illustrates a genomic approach for identifying candidate cross-species biomarkers of cirrhosis/fibrosis for humans and rats, and a previously known biomarker of fibrosis (APOA1) and a novel candidate biomarker of fibrosis, FETUB were identified. As more "omic" databases are built, a reservoir of molecular information will become available for toxicologist to gain more extensive views on the physiological alterations induced by adverse events, which will inevitably lead to the development of better tools for predicting, identifying, categorizing, and determining cross-species impact of the toxicity and ultimate provide a novel scientific scaffold for improving safety assessment protocols. JF - Toxicology Mechanisms and Methods AU - Orr AD - Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Office of Clinical Pharmacology, Silver Spring, MD, 20903-0002, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 79 EP - 87 VL - 16 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Cirrhosis KW - Fibrosis KW - Drug development KW - Toxicity KW - biomarkers KW - scaffolds KW - Hepatitis KW - Gene expression KW - Drug discovery KW - Databases KW - Reviews KW - Liver KW - Pharmaceuticals KW - genomics KW - Side effects KW - V 22410:Animal Diseases KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17142121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Toxicogenomics+and+Cross-Species+Biomarker+Discovery%3A+Applications+in+Drug+Discovery+and+Safely+Assessment&rft.au=Orr&rft.aulast=Orr&rft.aufirst=&rft.date=2006-01-01&rft.volume=16&rft.issue=2-3&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376520600558317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cirrhosis; Fibrosis; Drug development; Toxicity; biomarkers; scaffolds; Gene expression; Hepatitis; Databases; Drug discovery; Reviews; Liver; Pharmaceuticals; genomics; Side effects DO - http://dx.doi.org/10.1080/15376520600558317 ER - TY - JOUR T1 - Some Major Landmarks in the Path from Nuclein to Human Genome AN - 17137409; 6757579 AB - The completion of sequencing of the human genome as well as the genomes of other species is a spectacular achievement of 20th-century biology. It is appropriately regarded as a turning point in biology and medicine for the 21st century. Knowledge of the human genome will presumably help us understand the genetic instructions that make us human. By learning about the gene sequences, the functional dynamics of the genome as well as the individual genetic differences, scientists hope to understand the molecular basis of the normal state and the diseased state of life on one hand, and develop ways to individualize medicine and nutrition on the other hand. Thus, the science of genomics that has grown out of this genome sequencing effort is expected to revolutionize the future of biology itself. The present article is an attempt to briefly summarize some major landmarks in the path that began with the discovery of "nuclein" and led to the completion of the human genome sequencing. JF - Toxicology Mechanisms and Methods AU - Choudhuri, S AD - Division of Biotechnology and GRAS Notice Review, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition Y1 - 2006 PY - 2006 DA - 2006 SP - 137 EP - 159 VL - 16 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Genetics Abstracts; Toxicology Abstracts KW - Learning KW - genomics KW - Nutrition KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17137409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Some+Major+Landmarks+in+the+Path+from+Nuclein+to+Human+Genome&rft.au=Choudhuri%2C+S&rft.aulast=Choudhuri&rft.aufirst=S&rft.date=2006-01-01&rft.volume=16&rft.issue=2-3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376520600558606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Learning; genomics; Nutrition DO - http://dx.doi.org/10.1080/15376520600558606 ER - TY - JOUR T1 - Gaining Confidence on Molecular Classification through Consensus Modeling and Validation AN - 17134178; 6757572 AB - Current advances in genomics, proteomics, and metabonomics would result in a constellation of benefits in human health. Classification applying supervised learning methods to omics data as one of the molecular classification approaches has enjoyed its growing role in clinical application. However, the utility of a molecular classifier will not be fully appreciated unless its quality is carefully validated. A clinical omics data is usually noisy with the number of independent variables far more than the number of subjects and, possibly, with a skewed subject distribution. Given that, the consensus approach holds an advantage over a single classifier. Thus, the focus of this review is mainly placed on how validating a molecular classifier using Decision Forest (DF), a robust consensus approach. We recommended that a molecular classifier has to be assessed with respect to overall prediction accuracy, prediction confidence and chance correlation, which can be readily achieved in DF. The commonalities and differences between external validation and cross-validation are also discussed for perspective use of these methods to validate a DF classifier. In addition, the advantages of using consensus approaches for identification of potential biomarkers are also rationalized. Although specific DF examples are used in this review, the provided rationales and recommendations should be equally applicable to other consensus methods. JF - Toxicology Mechanisms and Methods AU - Tong, W AU - Fang, H AU - Xie, Q AU - Hong, H AU - Shi, L AU - Perkins, R AU - Scherf, U AU - Goodsaid, F AU - Frueh, F AD - Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, AR, 72079, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 59 EP - 68 VL - 16 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Toxicology Abstracts KW - Learning KW - Data processing KW - Classification KW - Reviews KW - Forests KW - proteomics KW - genomics KW - biomarkers KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17134178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Gaining+Confidence+on+Molecular+Classification+through+Consensus+Modeling+and+Validation&rft.au=Tong%2C+W%3BFang%2C+H%3BXie%2C+Q%3BHong%2C+H%3BShi%2C+L%3BPerkins%2C+R%3BScherf%2C+U%3BGoodsaid%2C+F%3BFrueh%2C+F&rft.aulast=Tong&rft.aufirst=W&rft.date=2006-01-01&rft.volume=16&rft.issue=2-3&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376520600558259 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Learning; Data processing; Classification; Reviews; Forests; genomics; proteomics; biomarkers DO - http://dx.doi.org/10.1080/15376520600558259 ER - TY - JOUR T1 - Mutagenicity of bromate: Implications for cancer risk assessment AN - 17106718; 6735534 AB - Bromate (BrO sub(3) super(-)) is a rodent carcinogen that is formed as a drinking water ozone disinfection by-product and also used in some food and consumer products. Therefore, bromate is subject to assessment for its risk to humans. Because the selection of an appropriate model for conducting quantitative cancer risk assessment is based upon an understanding of the chemical's mode-of-action, it is necessary to determine whether the chemical is a mutagenic carcinogen. We present a review of the available information concerning the weight-of-the- evidence that bromate is a mutagenic carcinogen. The evidence indicates that bromate is mutagenic and that this activity is mediated by the formation of oxidative damage to the DNA, thus resulting in chromosomal damage. Not only does bromate induce genetic damage in vitro, it is also demonstrated to induce mutations in the kidney of exposed rats. This is significant because the rat kidney is one of the target tissues for tumor induction. While it is clear that bromate can cause damage in the target tissue, it is not clear whether bromate is a mutagenic carcinogen, that is, whether the observed tumors result from a mutagenic mode-of-action. Further research is needed to clarify bromate's mode- of-action. However, in the absence of additional information, it is reasonable, based on an extensive database, to assume that bromate induces tumors via oxidative damage that causes chromosomal breakage. JF - Toxicology AU - Moore, Martha M AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, HFT-120, NCTR, 3900 NCTR Rd., Jefferson, AR 72079, USA, mmmoore@nctr.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 190 EP - 196 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 221 IS - 2-3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Potassium bromate KW - Sodium bromate KW - Mutagenicity KW - Genotoxicity KW - Risk assessment KW - Disinfection KW - Animal models KW - Carcinogens KW - Cancer KW - Models KW - Databases KW - DNA damage KW - Reviews KW - Kidney KW - DNA KW - Consumers KW - Drinking water KW - Mutation KW - Ozone KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Mutagenicity+of+bromate%3A+Implications+for+cancer+risk+assessment&rft.au=Moore%2C+Martha+M%3BChen%2C+Tao&rft.aulast=Moore&rft.aufirst=Martha&rft.date=2006-01-01&rft.volume=221&rft.issue=2-3&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2005.12.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Disinfection; Mutagenicity; Animal models; Carcinogens; Cancer; Models; DNA damage; Databases; Reviews; DNA; Kidney; Consumers; Drinking water; Mutation; Ozone DO - http://dx.doi.org/10.1016/j.tox.2005.12.018 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study AN - 17106507; 6736180 AB - Metolachlor is one of the most widely used herbicides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to metolachlor in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. A total of 50,193 pesticide applicators were included. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997; average length of follow-up was 7.33 years. Two metolachlor exposure metrics were used : (i) lifetime days personally mixed or applied metolachlor and (ii) intensity-weighted lifetime days (lifetime days X an intensity level). Poisson regression analysis was used to estimate relative risks (RR) and 95% confidence intervals (95%CI) for cancer subtypes by tertiles of metolachlor exposure. No clear risk for any cancer subtype was found for exposure to metolachlor. A significantly decreased RR was found for prostate cancer in the highest category of lifetime days exposure (RR = 0.59; 95%CI, 0.39-0.89) and in the second highest category of intensity- weighted lifetime days exposure (RR = 0.66; 95%CI, 0.45-0.97); however, the test for trend was not significant for either exposure metric. A nonsignificantly increased risk was found for lung cancer with lifetime days exposure in the highest category (RR = 2.37; 95%CI, 0.97-5.82, p-trend = 0.03) but not with intensity-weighted lifetime days. Given the widespread use of metolachlor and the frequent detection of metolachlor in both surface and ground water, future analyses of the AHS will allow further examination of long-term health effects, including lung cancer and the less common cancers. JF - International Journal of Cancer AU - Rusiecki, Jennifer A AU - Hou, Lifang AU - Lee, Won Jin AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Lubin, Jay H AU - Bonner, Matthew AU - Samanic, Claudine AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael CR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA, usiecki@usuhs.mil Y1 - 2006 PY - 2006 DA - 2006 SP - 3118 EP - 3123 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - metolachlor cancer pesticides herbicides applicators KW - Metolachlor KW - Risk assessment KW - Agriculture KW - USA, North Carolina KW - Herbicides KW - Agrochemicals KW - Prostate cancer KW - USA, Iowa KW - Pesticides KW - Regression analysis KW - Ground water KW - Groundwater KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - X 24134:Pathology KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+metolachlor+in+the+Agricultural+Health+Study&rft.au=Rusiecki%2C+Jennifer+A%3BHou%2C+Lifang%3BLee%2C+Won+Jin%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay+H%3BBonner%2C+Matthew%3BSamanic%2C+Claudine%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+CR&rft.aulast=Rusiecki&rft.aufirst=Jennifer&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3118&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21758 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Agriculture; Risk assessment; Metolachlor; Prostate cancer; Pesticides; Ground water; Regression analysis; Herbicides; Occupational exposure; Lung cancer; Groundwater; Agrochemicals; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1002/ijc.21758 ER - TY - JOUR T1 - Protection against an aerogenic Mycobacterium tuberculosis infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses AN - 17106472; 6737825 AB - Although vaccination against tuberculosis (TB) was initiated more than 80 years ago, the correlates of protective immunity against infection by Mycobacterium tuberculosis have still not been well defined. To investigate the vaccine-induced immune responses against TB, we evaluated the early pulmonary cytokine responses elicited by a low dose M. tuberculosis aerogenic challenge in mice that had been immunized with either BCG or a TB DNA vaccine cocktail, two vaccine preparations that induce long-term protection in the mouse model of pulmonary TB. Using three different assays, we showed that specific cytokine responses were elevated in the lungs of vaccinated mice (relative to naive controls) during the second week post-challenge. By measuring cytokine levels in the bronchoalveolar lavage fluid (BAL) and cytokine mRNA concentrations in pulmonary cells, the levels of IFN- gamma , IL-12, and RANTES were shown to be elevated from days 7-14 post-challenge in the lungs. By intracellular cytokine staining (ICS), increased numbers of lung CD4 and CD8 cells expressing IFN- gamma were also seen at days 10 and 14 after the infection. Moreover, increased post-challenge IFN- gamma levels were detected using the ICS and cytokine mRNA assays in aging BCG-immunized mice that had been effectively boosted with a TB DNA vaccine. Taken together, these data suggest that the post- infection induction of early type 1 cytokine responses correlate with the induction of long-term protective immunity in vaccinated mice. JF - Vaccine AU - Goter-Robinson, Carol AU - Derrick, Steven C AU - Yang, Amy Li AU - Jeon, Bo Young AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Building 29/Room 509, CBER/FDA, 29 Lincoln Dr., Bethesda, MD 20892, USA, derrick@cber.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3522 EP - 3529 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 17 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Tuberculosis KW - BCG KW - DNA Vaccines KW - Interferon- gamma KW - gamma -Interferon KW - Data processing KW - Aging KW - Lung diseases KW - Animal models KW - RANTES KW - Immunity KW - CD8 antigen KW - Infection KW - Alveoli KW - mRNA KW - Interleukin 12 KW - CD4 antigen KW - Bronchus KW - DNA vaccines KW - Lung KW - Cytokines KW - Immune response KW - Vaccines KW - Mycobacterium tuberculosis KW - J 02834:Vaccination and immunization KW - F 06100:Vaccines - active immunity KW - N 14830:RNA KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Protection+against+an+aerogenic+Mycobacterium+tuberculosis+infection+in+BCG-immunized+and+DNA-vaccinated+mice+is+associated+with+early+type+I+cytokine+responses&rft.au=Goter-Robinson%2C+Carol%3BDerrick%2C+Steven+C%3BYang%2C+Amy+Li%3BJeon%2C+Bo+Young%3BMorris%2C+Sheldon+L&rft.aulast=Goter-Robinson&rft.aufirst=Carol&rft.date=2006-01-01&rft.volume=24&rft.issue=17&rft.spage=3522&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Data processing; Aging; Animal models; Lung diseases; RANTES; CD8 antigen; Immunity; Infection; Alveoli; mRNA; Interleukin 12; CD4 antigen; DNA vaccines; Bronchus; BCG; Lung; Cytokines; Tuberculosis; Vaccines; Immune response; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2006.02.005 ER - TY - JOUR T1 - APE1 genotype and risk of bladder cancer: Evidence for effect modification by smoking AN - 17104612; 6736187 AB - Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T[rarr]G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an association that was modified by cigarette smoking. To explore the association between APE1 genotype, smoking and bladder cancer risk, we examined data from an existing case-control study of bladder cancer patients (n = 239) and control individuals (n = 215) recruited from urology clinics at 2 hospitals in North Carolina. Genotype at the polymorphic site was determined using allele-specific primer extension reactions, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. We found no overall association between APE1 genotype and bladder cancer risk. In stratified analyses, however, a positive association with risk was observed with an increasing number of Glu alleles among never smokers, but not among smokers (p-value for interaction = 0.005). We can speculate that small allelic differences that are apparent in never smokers are obscured by the large amount of DNA damage found in smokers. Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously. Published 2006 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Terry, Paul D AU - Umbach, David M AU - Taylor, Jack A AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA, taylor@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3170 EP - 3173 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - urinary bladder KW - Risk Abstracts KW - bladder neoplasms apurinic endonuclease polymorphism smoking case- control studies KW - Cytotoxicity KW - Cigarette smoking KW - DNA KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17104612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=APE1+genotype+and+risk+of+bladder+cancer%3A+Evidence+for+effect+modification+by+smoking&rft.au=Terry%2C+Paul+D%3BUmbach%2C+David+M%3BTaylor%2C+Jack+A&rft.aulast=Terry&rft.aufirst=Paul&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3170&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21768 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Cigarette smoking; DNA; Cancer; Lung cancer DO - http://dx.doi.org/10.1002/ijc.21768 ER - TY - JOUR T1 - Passive surveillance for generalized vaccinia in the United States using the Vaccine Adverse Event Reporting System (VAERS) AN - 17102915; 6737838 AB - Generalized vaccinia (GV) is an adverse event specifically associated with smallpox vaccination, but shares clinical features with many common non-vaccine related rashes. We assessed the utility of passive reporting for GV surveillance by reviewing all Vaccine Adverse Event Reporting System (VAERS) reports of any post-smallpox vaccination rash in civilians and military personnel. Methods We reviewed all reports submitted to VAERS between 12/12/2002 and 3/1 2004 for post-smallpox vaccine (SPV) rashes concerning civilians and military personnel. We evaluated the information contained in the reports independent of VAERS adverse event coding (GV or not GV). We classified the rash reports based on the recently published GV case definition from the Centers for Disease Control and Prevention. Results Of the 936 rash reports after SPV, 92 were coded as GV. We classified 12 of the 92 as probable GV, and 1 as confirmed GV (14% probable or confirmed). Among the 844 reports not coded as GV, we classified 32 as either probable or confirmed GV (4%). Probable or confirmed reports that were coded as GV were similar to probable or confirmed reports not coded as GV with respect to demographic characteristics of the report subjects, and the location and phenotype (e.g., pustular, vesicular, etc.) of the rashes. Conclusions A prospective study that applies well-defined clinical, histopathological, and laboratory criteria to smallpox-vaccinated patients with rashes would be necessary to distinguish GV from common alternative diagnoses with which it is easily confused. JF - Vaccine AU - Bryant-Genevier, Marthe AU - O'Connell, Kathryn AU - Ball, Robert AU - Braun, MMiles AU - McMahon, Ann AD - CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA, bryant-genevier@cber.fda.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3632 EP - 3635 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 17 SN - 0264-410X, 0264-410X KW - smallpox KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Generalized vaccinia KW - Smallpox vaccination KW - Passive surveillance KW - vaccines KW - Data collection KW - Vaccinia KW - Disease control KW - Histopathology KW - Vaccination KW - Demography KW - Smallpox KW - Exanthema KW - USA KW - Reviews KW - prevention KW - Vaccines KW - Military KW - Side effects KW - Military personnel KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17102915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Passive+surveillance+for+generalized+vaccinia+in+the+United+States+using+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29&rft.au=Bryant-Genevier%2C+Marthe%3BO%27Connell%2C+Kathryn%3BBall%2C+Robert%3BBraun%2C+MMiles%3BMcMahon%2C+Ann&rft.aulast=Bryant-Genevier&rft.aufirst=Marthe&rft.date=2006-01-01&rft.volume=24&rft.issue=17&rft.spage=3632&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.01.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smallpox; Demography; Exanthema; Vaccinia; Disease control; Vaccines; Vaccination; Military personnel; Data collection; vaccines; Reviews; prevention; Histopathology; Military; Side effects; USA DO - http://dx.doi.org/10.1016/j.vaccine.2006.01.052 ER -